PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14530333-7	2003	In contrast, benzo(a)pyrene, another AHR ligand, still caused thymic involution in Lck-Cre;Arnt(flox/Delta) mice.	Benzo(a)pyrene	13-27	aryl-hydrocarbon receptor	Mus musculus	37-40
14530333-7	2003	In contrast, benzo(a)pyrene, another AHR ligand, still caused thymic involution in Lck-Cre;Arnt(flox/Delta) mice.	Benzo(a)pyrene	13-27	lymphocyte protein tyrosine kinase	Mus musculus	83-86
14530333-7	2003	In contrast, benzo(a)pyrene, another AHR ligand, still caused thymic involution in Lck-Cre;Arnt(flox/Delta) mice.	Benzo(a)pyrene	13-27	aryl hydrocarbon receptor nuclear translocator	Mus musculus	91-95
12927582-0	2003	Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene.	Benzo(a)pyrene	104-118	aryl hydrocarbon receptor	Rattus norvegicus	30-33
12927582-0	2003	Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene.	Benzo(a)pyrene	104-118	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	38-44
12927582-8	2003	Hepatic upregulation of the aryl hydrocarbon receptor may modulate the potential for benzo(a)pyrene toxicity via the activation of cytochrome P450 and the subsequent deposition of lipophillic metabolites to developing central nervous system structures such as cerebral cortex and hippocampus.	Benzo(a)pyrene	85-99	aryl hydrocarbon receptor	Rattus norvegicus	28-53
14761401-0	2003	[The expression of cytochrome P450 1A1 of endothelial cells induced by benzo(a)pyrene].	Benzo(a)pyrene	71-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-38
14761401-1	2003	OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells.	Benzo(a)pyrene	36-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-116
14761401-1	2003	OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells.	Benzo(a)pyrene	36-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
14761401-1	2003	OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells.	Benzo(a)pyrene	52-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-116
14761401-1	2003	OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells.	Benzo(a)pyrene	52-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
14761401-4	2003	RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1.	Benzo(a)pyrene	134-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	105-111
14761401-4	2003	RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1.	Benzo(a)pyrene	134-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	105-111
14761401-4	2003	RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1.	Benzo(a)pyrene	218-221	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	105-111
14761401-4	2003	RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1.	Benzo(a)pyrene	218-221	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	105-111
14761401-6	2003	CONCLUSION: BaP could induce part of endothelial cells to synthesize CYP1A1.	Benzo(a)pyrene	12-15	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-75
12965116-12	2003	It is concluded that hashish induced the expression of CYP 2E1 and other carcinogen-metabolizing enzymes activities, and this induction could potentiate the deleterious effects of N-nitrosamines and aromatic hydrocarbons, e.g. benzo(a)pyrene, upon the liver and probably other organs.	Benzo(a)pyrene	227-241	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	55-62
12807757-3	2003	The current study examines the ability of acrolein to modulate the effect of benzo[a]pyrene (B[a]P), a major carcinogen found in smoke, on p53.	Benzo(a)pyrene	77-91	tumor protein p53	Homo sapiens	139-142
12923061-5	2003	The regulation of lignin biosynthesis by BP was demonstrated by observing increased lignin deposition in bp mutants following bolting, decreased lignification in plants overexpressing BP, and aberrant lignin deposition in discrete regions of the bp stem.	Benzo(a)pyrene	105-107	homeobox knotted-like protein	Arabidopsis thaliana	41-43
12910533-1	2003	BACKGROUND: UGT1A10 exhibits glucuronidating activity against metabolites of the tobacco smoke carcinogen, benzo(a)pyrene, and is expressed highly in numerous target tissues for tobacco-related cancers including the upper aerodigestive tract.	Benzo(a)pyrene	107-121	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	12-19
12807757-0	2003	Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein.	Benzo(a)pyrene	14-28	tumor protein p53	Homo sapiens	37-40
12897247-7	2003	PNY is expressed in inflorescence and floral meristems and overlaps with BP in a discrete domain of the inflorescence meristem where we propose the internode is patterned.	Benzo(a)pyrene	73-75	POX (plant homeobox) family protein	Arabidopsis thaliana	0-3
12874452-7	2003	Systolic BP in adrenalectomy + Ang II and adrenalectomy + ALDO (238 +/- 8 and 241 +/- 9 mmHg, respectively) was similar to SHAM.	Benzo(a)pyrene	9-11	angiotensinogen	Rattus norvegicus	31-37
12807725-4	2003	Benzo[a]pyrene, another potent carcinogen of CS, can also activate NF-kappaB, but by an as yet unknown mechanism.	Benzo(a)pyrene	0-14	nuclear factor kappa B subunit 1	Homo sapiens	67-76
12847556-0	2003	BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction.	Benzo(a)pyrene	0-2	dopamine receptor D3	Rattus norvegicus	20-40
12847556-14	2003	These interesting preclinical findings with BP 897 provide additional validation for dopamine D(3) receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (CNS) disorders.	Benzo(a)pyrene	44-46	dopamine receptor D3	Rattus norvegicus	85-107
12819233-7	2003	Correlation analysis showed that, in contrast to the ACE expression, upregulation of chymase correlated significantly with the increase in BP and the severity of collagen matrix deposition within the glomerulus, tubulointerstitium, and arterial walls (all with P < 0.001).	Benzo(a)pyrene	139-141	chymase 1	Homo sapiens	85-92
12884409-0	2003	Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.	Benzo(a)pyrene	115-129	aryl-hydrocarbon receptor	Mus musculus	23-48
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	52-77
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	79-82
14499136-2	2003	We tested the hypothesis that adrenergic receptor agonists increase the BP of [18F]FECNT for the DAT.	Benzo(a)pyrene	72-74	solute carrier family 6 member 3	Homo sapiens	97-100
12893519-12	2003	Rat lung slice CYP1A1 mRNA levels were increased up to 8.3-fold after treatment for 24 h with 2 and 10 micro g ml(-1) ARO, 0.5 and 5 micro M BNF, and 20 micro M BP.	Benzo(a)pyrene	161-163	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	15-21
12799773-3	2003	Chr, BkF and BaP acted as AhR agonists in LNCaP cells, while Ant and Pyr did not.	Benzo(a)pyrene	13-16	aryl hydrocarbon receptor	Homo sapiens	26-29
12799773-8	2003	Gel mobility shift assays revealed that Chr, BkF and BaP inhibited the binding of AR in nuclear extracts to oligonucleotide probes containing the AR-responsive element (ARE), whereas Ant and Pyr had no effect.	Benzo(a)pyrene	53-56	androgen receptor	Homo sapiens	82-84
12851037-3	2003	In untreated mouse liver microsomes, tanshinone IIA selectively inhibited 7-ethoxyresorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation (MROD) activities without affecting the oxidation of benzo(a)pyrene, tolbutamide, N-nitrosodimethylamine and nifedipine.	Benzo(a)pyrene	206-220	ATPase, class II, type 9A	Mus musculus	48-51
14582526-3	2003	The ultimate goal was to relate the BP (or the SMA) to external devices via conversion of potentials to a language "understood" by the receiving devices.	Benzo(a)pyrene	36-38	survival of motor neuron 1, telomeric	Homo sapiens	47-50
12880561-0	2003	[Antisense ERCC1 RNA decreases the repair capability of damaged DNA in lung cancer cells induced by benzo[a]pyrene].	Benzo(a)pyrene	100-114	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	11-16
12880561-1	2003	OBJECTIVE: To investigate the effect of ERCC1 gene on the repair capability of damaged DNA in lung cancer A549 cells induced by benzo[a]pyrene.	Benzo(a)pyrene	128-142	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	40-45
12880561-12	2003	CONCLUSION: Antisense ERCC1 RNA decreased the repair capability for damaged DNA in lung cancer cells induced by benzo[a]pyrene.	Benzo(a)pyrene	112-126	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	22-27
12566446-3	2003	In this report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible with aryl hydrocarbon receptor (Ah receptor) ligands such as 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD), beta-naphthoflavone, and benzo[a]pyrene metabolites.	Benzo(a)pyrene	221-235	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	63-69
12566446-3	2003	In this report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible with aryl hydrocarbon receptor (Ah receptor) ligands such as 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD), beta-naphthoflavone, and benzo[a]pyrene metabolites.	Benzo(a)pyrene	221-235	aryl hydrocarbon receptor	Homo sapiens	98-123
12566446-3	2003	In this report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible with aryl hydrocarbon receptor (Ah receptor) ligands such as 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD), beta-naphthoflavone, and benzo[a]pyrene metabolites.	Benzo(a)pyrene	221-235	aryl hydrocarbon receptor	Homo sapiens	125-136
12738245-0	2003	Environmental polycyclic aromatic hydrocarbons, benzo(a) pyrene (BaP) and BaP-quinones, enhance IgE-mediated histamine release and IL-4 production in human basophils.	Benzo(a)pyrene	48-63	interleukin 4	Homo sapiens	131-135
12670496-3	2003	We compared the effects of 11 representative natural polyphenols, which normally occur in food, on different activities of CYP1A1, namely epoxidation of 7,8-dihydrodiol-benzo[a]pyrene, the terminal step in the activation leading to the ultimate carcinogenic diolepoxides, hydroxylation of benzo[a]pyrene, and EROD.	Benzo(a)pyrene	169-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
12657491-5	2003	For this reason, in this work, the time dependent responses of the hepatic CYP1A and Pgp, to the prototypical CYP1A inducers, benzo(a)pyrene (B(a)P), 3-methylcholanthrene (3MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in X. laevis have been assessed at the protein level and compared.	Benzo(a)pyrene	126-140	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	75-80
12657491-5	2003	For this reason, in this work, the time dependent responses of the hepatic CYP1A and Pgp, to the prototypical CYP1A inducers, benzo(a)pyrene (B(a)P), 3-methylcholanthrene (3MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in X. laevis have been assessed at the protein level and compared.	Benzo(a)pyrene	126-140	phosphoglycolate phosphatase	Homo sapiens	85-88
12657491-5	2003	For this reason, in this work, the time dependent responses of the hepatic CYP1A and Pgp, to the prototypical CYP1A inducers, benzo(a)pyrene (B(a)P), 3-methylcholanthrene (3MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in X. laevis have been assessed at the protein level and compared.	Benzo(a)pyrene	142-147	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	75-80
12657491-5	2003	For this reason, in this work, the time dependent responses of the hepatic CYP1A and Pgp, to the prototypical CYP1A inducers, benzo(a)pyrene (B(a)P), 3-methylcholanthrene (3MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in X. laevis have been assessed at the protein level and compared.	Benzo(a)pyrene	142-147	phosphoglycolate phosphatase	Homo sapiens	85-88
12657491-5	2003	For this reason, in this work, the time dependent responses of the hepatic CYP1A and Pgp, to the prototypical CYP1A inducers, benzo(a)pyrene (B(a)P), 3-methylcholanthrene (3MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in X. laevis have been assessed at the protein level and compared.	Benzo(a)pyrene	142-147	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	110-115
12657491-8	2003	Western blot evidenced that a single injection of B(a)P (100 mg/kg), 3MC (20 mg/kg), and TCDD (3 microg/kg) elicited a statistically significant induction of hepatic CYP1A at all time points considered (72, 120 and 168 h) which decreased in time.	Benzo(a)pyrene	50-55	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	166-171
12657491-13	2003	For the first time the modulation of CYP1A and Pgp levels by B(a)P, 3MC and in particular by TCDD and T(3) in Xenopus has been demonstrated and the results herewith indicate that the two target defence mechanisms respond to AHR agonists in a dissimilar way in terms of proteins induction in Xenopus.	Benzo(a)pyrene	61-66	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	37-42
12657491-13	2003	For the first time the modulation of CYP1A and Pgp levels by B(a)P, 3MC and in particular by TCDD and T(3) in Xenopus has been demonstrated and the results herewith indicate that the two target defence mechanisms respond to AHR agonists in a dissimilar way in terms of proteins induction in Xenopus.	Benzo(a)pyrene	61-66	phosphoglycolate phosphatase	Homo sapiens	47-50
12657491-13	2003	For the first time the modulation of CYP1A and Pgp levels by B(a)P, 3MC and in particular by TCDD and T(3) in Xenopus has been demonstrated and the results herewith indicate that the two target defence mechanisms respond to AHR agonists in a dissimilar way in terms of proteins induction in Xenopus.	Benzo(a)pyrene	61-66	aryl hydrocarbon receptor L homeolog	Xenopus laevis	224-227
12738245-0	2003	Environmental polycyclic aromatic hydrocarbons, benzo(a) pyrene (BaP) and BaP-quinones, enhance IgE-mediated histamine release and IL-4 production in human basophils.	Benzo(a)pyrene	65-68	interleukin 4	Homo sapiens	131-135
12667665-5	2003	The fractalkine CSF/serum ratios (a measure of the chemotactic gradient) were significantly elevated in BM, VM and GBS; furthermore, they tended to be increased in BP and to be decreased in MS.	Benzo(a)pyrene	164-166	C-X3-C motif chemokine ligand 1	Homo sapiens	4-15
12655650-1	2003	BACKGROUND: A relation between the changes in DNA content and chromatin supra-organization and the expression of gradual steps of tumorigenesis has been assessed by image analysis in human breast epithelial cells (MCF-10F) treated with benzo[a]pyrene (BP) (cell lines BP1, BP1-E, BP1-Tras, and others).	Benzo(a)pyrene	236-250	BP1	Homo sapiens	268-271
12655650-1	2003	BACKGROUND: A relation between the changes in DNA content and chromatin supra-organization and the expression of gradual steps of tumorigenesis has been assessed by image analysis in human breast epithelial cells (MCF-10F) treated with benzo[a]pyrene (BP) (cell lines BP1, BP1-E, BP1-Tras, and others).	Benzo(a)pyrene	236-250	BP1	Homo sapiens	273-276
12655650-1	2003	BACKGROUND: A relation between the changes in DNA content and chromatin supra-organization and the expression of gradual steps of tumorigenesis has been assessed by image analysis in human breast epithelial cells (MCF-10F) treated with benzo[a]pyrene (BP) (cell lines BP1, BP1-E, BP1-Tras, and others).	Benzo(a)pyrene	236-250	BP1	Homo sapiens	273-276
12655650-1	2003	BACKGROUND: A relation between the changes in DNA content and chromatin supra-organization and the expression of gradual steps of tumorigenesis has been assessed by image analysis in human breast epithelial cells (MCF-10F) treated with benzo[a]pyrene (BP) (cell lines BP1, BP1-E, BP1-Tras, and others).	Benzo(a)pyrene	252-254	BP1	Homo sapiens	268-271
12655650-1	2003	BACKGROUND: A relation between the changes in DNA content and chromatin supra-organization and the expression of gradual steps of tumorigenesis has been assessed by image analysis in human breast epithelial cells (MCF-10F) treated with benzo[a]pyrene (BP) (cell lines BP1, BP1-E, BP1-Tras, and others).	Benzo(a)pyrene	252-254	BP1	Homo sapiens	273-276
12655650-1	2003	BACKGROUND: A relation between the changes in DNA content and chromatin supra-organization and the expression of gradual steps of tumorigenesis has been assessed by image analysis in human breast epithelial cells (MCF-10F) treated with benzo[a]pyrene (BP) (cell lines BP1, BP1-E, BP1-Tras, and others).	Benzo(a)pyrene	252-254	BP1	Homo sapiens	273-276
12733653-9	2003	We found that cells containing BPDE-DNA adducts and nuclear p53 expression significantly increased between 2 and 10 weeks of BaP-UVA treatment, whereas neither BPDE-DNA adducts nor significant changes in p53 were observed in untreated skin.	Benzo(a)pyrene	125-128	transformation related protein 53, pseudogene	Mus musculus	60-63
12649394-0	2003	Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates.	Benzo(a)pyrene	30-44	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	8-26
12649394-8	2003	BP treatment of SMCs resulted in induction of aryl hydrocarbon hydroxylase (AHH) activity and CYP1B1, but not CYP1A1, apoprotein.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-74
12649394-8	2003	BP treatment of SMCs resulted in induction of aryl hydrocarbon hydroxylase (AHH) activity and CYP1B1, but not CYP1A1, apoprotein.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	76-79
12649394-8	2003	BP treatment of SMCs resulted in induction of aryl hydrocarbon hydroxylase (AHH) activity and CYP1B1, but not CYP1A1, apoprotein.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	94-100
12649394-9	2003	EP also blocked AHH induction by BP.	Benzo(a)pyrene	33-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	16-19
12649394-10	2003	In conclusion, the results of this study support the hypothesis that in SMCs, which are target sites for the development of atherosclerosis, the major bioactivation pathway of BP entails CYP1B1-mediated formation of the 3-OH-BP and BPQ, which are proximate genotoxic metabolites that may in turn get transformed to ultimate DNA-binding metabolites, which may contribute to atherogenesis by PAHs.	Benzo(a)pyrene	176-178	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	187-193
12660004-2	2003	Glutathione S-transferase p1 (GSTP1), the most abundant GST isoform in the lung, metabolizes numerous carcinogenic compounds including benzo[a]pyrene, a tobacco carcinogen.	Benzo(a)pyrene	135-149	glutathione S-transferase pi 1	Homo sapiens	30-35
12417974-8	2003	Treatment with gentamicin for 6 or 12 h promoted the expression of active caspase-3 and active caspase-9 in many hair cells along the BP as shown by immunohistochemistry.	Benzo(a)pyrene	134-136	caspase 3	Homo sapiens	74-83
12633750-8	2003	This is followed by oxygen transfer to the most electropositive carbon atoms, C-6, C-1, and C-3, with formation of 6-OHBP (and its quinones), 1-OHBP, and 3-OHBP, respectively, or the most electropositive 4,5-, 7,8-, and 9,10- double bonds, with formation of BP 4,5-, 7,8-, or 9,10-oxide.	Benzo(a)pyrene	119-121	complement C6	Rattus norvegicus	78-81
12633750-8	2003	This is followed by oxygen transfer to the most electropositive carbon atoms, C-6, C-1, and C-3, with formation of 6-OHBP (and its quinones), 1-OHBP, and 3-OHBP, respectively, or the most electropositive 4,5-, 7,8-, and 9,10- double bonds, with formation of BP 4,5-, 7,8-, or 9,10-oxide.	Benzo(a)pyrene	119-121	complement C3	Rattus norvegicus	92-95
12456389-4	2003	Cultured macrophages (RAW 264.7 cells) exposed continuously to a well-defined model of particulate matter (benzo[a]pyrene adsorbed onto carbon black) induced HO-1 gene expression in a time-dependent manner.	Benzo(a)pyrene	107-121	heme oxygenase 1	Mus musculus	158-162
12456389-5	2003	Likewise, the addition of benzo[a]pyrene-1,6-quinone, a redox cycling metabolite of benzo[a]pyrene, to RAW cells also induced HO-1.	Benzo(a)pyrene	26-40	heme oxygenase 1	Mus musculus	126-130
12663505-0	2003	Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice.	Benzo(a)pyrene	53-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
12663505-3	2003	Previously, we demonstrated that nrf2-deficient mice had low basal expression of phase 2 enzymes and were substantially more susceptible to benzo[a]pyrene (B[a]P)-induced neoplasia of the forestomach than wild-type.	Benzo(a)pyrene	140-154	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
12663505-3	2003	Previously, we demonstrated that nrf2-deficient mice had low basal expression of phase 2 enzymes and were substantially more susceptible to benzo[a]pyrene (B[a]P)-induced neoplasia of the forestomach than wild-type.	Benzo(a)pyrene	156-161	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
12417974-8	2003	Treatment with gentamicin for 6 or 12 h promoted the expression of active caspase-3 and active caspase-9 in many hair cells along the BP as shown by immunohistochemistry.	Benzo(a)pyrene	134-136	caspase 9	Homo sapiens	95-104
12594260-3	2003	Treatment by BP markedly inhibited the formation of adherent macrophagic cells deriving from monocytes upon the action of either GM-CSF or M-CSF.	Benzo(a)pyrene	13-15	colony stimulating factor 2	Homo sapiens	129-135
12594260-3	2003	Treatment by BP markedly inhibited the formation of adherent macrophagic cells deriving from monocytes upon the action of either GM-CSF or M-CSF.	Benzo(a)pyrene	13-15	colony stimulating factor 1	Homo sapiens	130-135
12594260-5	2003	Exposure to BP also strongly altered functional properties characterizing macrophagic cells such as endocytosis, phagocytosis, LPS-triggered production of TNF-alpha and stimulation of allogeneic lymphocyte proliferation.	Benzo(a)pyrene	12-14	tumor necrosis factor	Homo sapiens	155-164
12594260-6	2003	Moreover, formation of adherent macrophagic cells was decreased in response to PAHs distinct from BP such as dimethylbenz(a)anthracene and 3-methylcholanthrene, which interact, like BP, with the arylhydrocarbon receptor (AhR) known to mediate many PAH effects.	Benzo(a)pyrene	182-184	aryl hydrocarbon receptor	Homo sapiens	195-219
12594260-6	2003	Moreover, formation of adherent macrophagic cells was decreased in response to PAHs distinct from BP such as dimethylbenz(a)anthracene and 3-methylcholanthrene, which interact, like BP, with the arylhydrocarbon receptor (AhR) known to mediate many PAH effects.	Benzo(a)pyrene	182-184	aryl hydrocarbon receptor	Homo sapiens	221-224
12594260-8	2003	In addition, AhR was demonstrated to be present and functional in cultured monocytic cells, and the use of its antagonist alpha-naphtoflavone counteracted inhibitory effects of BP toward macrophagic differentiation.	Benzo(a)pyrene	177-179	aryl hydrocarbon receptor	Homo sapiens	13-16
12715424-10	2003	BP load value measured in group 0 was 14.57 + 21.3% of SBP and 13.92 + 22.99% of DBP inappropriate results.	Benzo(a)pyrene	0-2	selenium binding protein 1	Homo sapiens	55-58
12628579-7	2003	For example, CYP1B1 was induced 9-fold and 10-fold by benzo[a]pyrene and 3,4,3",4"-tetrachlorobiphenyl in livers of male and female mice, respectively, whereas in testis and ovary, the fold induction of CYP1B1 by two inducers was only 1.1 and 1.4, respectively.	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	13-19
12628579-7	2003	For example, CYP1B1 was induced 9-fold and 10-fold by benzo[a]pyrene and 3,4,3",4"-tetrachlorobiphenyl in livers of male and female mice, respectively, whereas in testis and ovary, the fold induction of CYP1B1 by two inducers was only 1.1 and 1.4, respectively.	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	203-209
12549910-1	2003	Murine class alpha glutathione S-transferase subunit types A2 (mGSTA2-2) and A1 (mGSTA1-1) have high catalytic efficiency for glutathione (GSH) conjugation of the ultimate carcinogenic metabolite of benzo[a]pyrene, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, [(+)-anti-BPDE].	Benzo(a)pyrene	199-213	glutathione S-transferase, alpha 2 (Yc2)	Mus musculus	63-71
12549910-1	2003	Murine class alpha glutathione S-transferase subunit types A2 (mGSTA2-2) and A1 (mGSTA1-1) have high catalytic efficiency for glutathione (GSH) conjugation of the ultimate carcinogenic metabolite of benzo[a]pyrene, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, [(+)-anti-BPDE].	Benzo(a)pyrene	199-213	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	81-89
12604189-1	2003	The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.	Benzo(a)pyrene	144-158	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	4-30
12604189-1	2003	The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.	Benzo(a)pyrene	144-158	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	32-39
12604189-1	2003	The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.	Benzo(a)pyrene	160-163	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	4-30
12604189-1	2003	The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.	Benzo(a)pyrene	160-163	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	32-39
12715424-10	2003	BP load value measured in group 0 was 14.57 + 21.3% of SBP and 13.92 + 22.99% of DBP inappropriate results.	Benzo(a)pyrene	0-2	D-box binding PAR bZIP transcription factor	Homo sapiens	81-84
12538730-1	2003	AT(2) receptor-disrupted (AT(2) -/-) mice provide a unique opportunity to investigate the cardiovascular and BP-related effects of NO depletion.	Benzo(a)pyrene	109-111	angiotensin II receptor, type 2	Mus musculus	0-14
12538731-9	2003	Intraarterial BP was somewhat higher in Apoe-/- mice compared with controls.	Benzo(a)pyrene	14-16	apolipoprotein E	Mus musculus	40-44
12538740-12	2003	ETB blockade induced a BP elevation with a decrease in urinary Na(+) excretion in normokalemic but not in hypokalemic rats.	Benzo(a)pyrene	23-25	endothelin receptor type B	Rattus norvegicus	0-3
12610655-6	2003	Such an approach has been validated for cocaine in animals, by using the dopamine D(3) receptor-selective partial agonist BP 897, which inhibits cocaine cue-induced drug-seeking behavior.	Benzo(a)pyrene	122-124	dopamine receptor D3	Rattus norvegicus	73-95
12559965-7	2003	Prototypic AHR agonists benzo[a]pyrene (BaP) or 7,12-dimethylbenzanthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) repressed T-cadherin mRNA levels.	Benzo(a)pyrene	24-38	aryl hydrocarbon receptor	Rattus norvegicus	11-14
12559965-7	2003	Prototypic AHR agonists benzo[a]pyrene (BaP) or 7,12-dimethylbenzanthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) repressed T-cadherin mRNA levels.	Benzo(a)pyrene	40-43	aryl hydrocarbon receptor	Rattus norvegicus	11-14
12527383-7	2003	These data indicate that the in situ activity of TGase 2 gives different results with different substrates, and suggest the possibility of overrepresentation of in situ TGase 2 activity when assayed with BP.	Benzo(a)pyrene	204-206	transglutaminase 2	Homo sapiens	49-56
12604189-5	2003	The effects of BaP were estimated in terms of dose-response and time-response, with regard to the serum level of several APPs such as alpha-1-acid-glycoprotein (AAG), alpha-1-antitrypsin (AAT), C-reactive protein (CRP), and haptoglobin (HPT).	Benzo(a)pyrene	15-18	orosomucoid 1	Rattus norvegicus	134-159
12604189-7	2003	The changes in serum proteins were compared with the results of BaP or LPS administration on both hepatic ALDH3A1 and total ALDH enzyme activities.	Benzo(a)pyrene	64-67	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	106-113
12604189-7	2003	The changes in serum proteins were compared with the results of BaP or LPS administration on both hepatic ALDH3A1 and total ALDH enzyme activities.	Benzo(a)pyrene	64-67	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	106-110
12604189-8	2003	The results showed that BaP induced CRP and HPT in a time-dependent way, proportional to that caused by LPS.	Benzo(a)pyrene	24-27	C-reactive protein	Rattus norvegicus	36-39
12604189-9	2003	Additionally, ALDH3A1, CRP, and HPT were induced by BaP subacute treatment, whereas another type of ALDH inducer, phenobarbital, did not affect the levels of APPs or ALDH3A1, but did increase ALDH1A3 activity.	Benzo(a)pyrene	52-55	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	14-21
12604189-9	2003	Additionally, ALDH3A1, CRP, and HPT were induced by BaP subacute treatment, whereas another type of ALDH inducer, phenobarbital, did not affect the levels of APPs or ALDH3A1, but did increase ALDH1A3 activity.	Benzo(a)pyrene	52-55	C-reactive protein	Rattus norvegicus	23-26
12527383-7	2003	These data indicate that the in situ activity of TGase 2 gives different results with different substrates, and suggest the possibility of overrepresentation of in situ TGase 2 activity when assayed with BP.	Benzo(a)pyrene	204-206	transglutaminase 2	Homo sapiens	169-176
12604189-9	2003	Additionally, ALDH3A1, CRP, and HPT were induced by BaP subacute treatment, whereas another type of ALDH inducer, phenobarbital, did not affect the levels of APPs or ALDH3A1, but did increase ALDH1A3 activity.	Benzo(a)pyrene	52-55	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	14-18
12538356-4	2003	Ultraviolet (UV) light from the sun and polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, are strongly implicated in the spectrum of p53 mutations found in human non-melanoma skin cancers and smoking-associated lung cancers, respectively.	Benzo(a)pyrene	82-96	tumor protein p53	Homo sapiens	141-144
12604189-11	2003	Considering the changes of APPs caused by BaP, this study further supports the suggestion that the induction of ALDH3A1 is related to an atypical hepatocyte inflammation produced by xenobiotics.	Benzo(a)pyrene	42-45	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	112-119
14556224-8	2003	Benzo[a]pyrene (BaP) exposure increased mutant frequency more than 25-fold above control and did not require an exogenous metabolic activation mixture.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
12459440-4	2002	Here, we provide biochemical evidence suggesting a role for DNA polymerase eta (Poleta) in mutagenesis induced by benzo[a]pyrene DNA adducts in cells.	Benzo(a)pyrene	114-128	DNA polymerase eta	Homo sapiens	60-78
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	121-135	aryl-hydrocarbon receptor	Mus musculus	4-15
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	121-135	aryl-hydrocarbon receptor	Mus musculus	17-20
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	121-135	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	64-68
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	121-135	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	84-90
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	137-139	aryl-hydrocarbon receptor	Mus musculus	4-15
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	137-139	aryl-hydrocarbon receptor	Mus musculus	17-20
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	137-139	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	64-68
12455047-3	2003	The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC).	Benzo(a)pyrene	137-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	84-90
12455047-5	2003	Wild-type [AHR (+/+)] mice or mice lacking the gene for the AHR were treated with a single dose (100 micromol/kg) of BP or MC, and hepatic DNA adducts were analyzed by (32)P-postlabeling.	Benzo(a)pyrene	117-119	aryl-hydrocarbon receptor	Mus musculus	60-63
12455047-6	2003	BP induced multiple hepatic DNA adducts in wild-type as well as AHR-null animals, suggesting the existence of AHR-independent mechanisms for BP metabolic activation.	Benzo(a)pyrene	0-2	aryl-hydrocarbon receptor	Mus musculus	64-67
12455047-6	2003	BP induced multiple hepatic DNA adducts in wild-type as well as AHR-null animals, suggesting the existence of AHR-independent mechanisms for BP metabolic activation.	Benzo(a)pyrene	0-2	aryl-hydrocarbon receptor	Mus musculus	110-113
12496043-2	2002	MPO is involved in the activation of a number of procarcinogens, including benzo(a)pyrene.	Benzo(a)pyrene	75-89	myeloperoxidase	Homo sapiens	0-3
12908430-1	2002	This work describes the fabrication and the application of an antibody-based fiber-optic nanosensor for in situ measurements of the carcinogen benzo[a]pyrene (BaP) in a single cell.	Benzo(a)pyrene	143-157	prohibitin 2	Homo sapiens	159-162
12507920-0	2002	CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers" lung: comparison with aromatic/hydrophobic adduct formation.	Benzo(a)pyrene	34-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
12507920-0	2002	CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers" lung: comparison with aromatic/hydrophobic adduct formation.	Benzo(a)pyrene	34-48	glutathione S-transferase mu 1	Homo sapiens	11-16
12507920-8	2002	These results are also consistent with the hypothesis that BP (PAH) induce G:C to T:A transversion mutations in the hotspot codons of the p53 tumor suppressor gene and are thus involved in malignant transformation of the lung tissue of smokers.	Benzo(a)pyrene	59-61	tumor protein p53	Homo sapiens	138-141
12444204-27	2002	There is an early rise in GFR and FF, consistent with increased postglomerular vascular resistance and a late rise in RVR with a fall in GFR, consistent with increased preglomerular vascular resistance that is accompanied by a rise in BP.	Benzo(a)pyrene	235-237	nuclear receptor subfamily 1, group D, member 2	Mus musculus	118-121
12444219-8	2002	Induction of cytoprotective heat-shock protein 70 preceded lipid peroxidation, rise in BP, or proteinuria.	Benzo(a)pyrene	87-89	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	28-49
12466554-6	2002	Interestingly, another human Y-family polymerase, polkappa, was able to extend dTMP inserted opposite a BaP DE dA adduct.	Benzo(a)pyrene	104-107	DNA polymerase lambda	Homo sapiens	50-58
12466554-0	2002	Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota.	Benzo(a)pyrene	27-41	DNA polymerase iota	Homo sapiens	134-153
12441364-2	2002	Both benzo[a]pyrene (BaP) and benz[a]anthracene (BaA) are known to weakly activate estrogen receptor (ER)-dependent reporter constructs.	Benzo(a)pyrene	5-19	estrogen receptor 1	Homo sapiens	83-100
12441364-2	2002	Both benzo[a]pyrene (BaP) and benz[a]anthracene (BaA) are known to weakly activate estrogen receptor (ER)-dependent reporter constructs.	Benzo(a)pyrene	5-19	estrogen receptor 1	Homo sapiens	102-104
12441364-2	2002	Both benzo[a]pyrene (BaP) and benz[a]anthracene (BaA) are known to weakly activate estrogen receptor (ER)-dependent reporter constructs.	Benzo(a)pyrene	21-24	estrogen receptor 1	Homo sapiens	83-100
12441364-2	2002	Both benzo[a]pyrene (BaP) and benz[a]anthracene (BaA) are known to weakly activate estrogen receptor (ER)-dependent reporter constructs.	Benzo(a)pyrene	21-24	estrogen receptor 1	Homo sapiens	102-104
14694596-9	2002	XPB and XPC gene expression increased to 4.5-fold and 11.2-fold respectively compared with basal level at 24 h treatment or 12 h after 24 h treatment with 10 mumol/L BaP respectively.	Benzo(a)pyrene	166-169	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	8-11
12432099-0	2002	Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene.	Benzo(a)pyrene	78-92	DNA polymerase lambda	Homo sapiens	0-8
12432099-4	2002	More importantly, Polkappa is able to bypass benzo[a]pyrene (B[a]P)-adducted guanine accurately and efficiently.	Benzo(a)pyrene	45-59	DNA polymerase lambda	Homo sapiens	18-26
12432099-4	2002	More importantly, Polkappa is able to bypass benzo[a]pyrene (B[a]P)-adducted guanine accurately and efficiently.	Benzo(a)pyrene	61-66	DNA polymerase lambda	Homo sapiens	18-26
12522893-11	2002	BP reduction was significant in fosinopril group from the first month (SBP 140.7 +/- 12.2, p = 0.021; DBP 87.2 +/- 6.2, p = 0.003).	Benzo(a)pyrene	0-2	selenium binding protein 1	Homo sapiens	71-74
12522893-11	2002	BP reduction was significant in fosinopril group from the first month (SBP 140.7 +/- 12.2, p = 0.021; DBP 87.2 +/- 6.2, p = 0.003).	Benzo(a)pyrene	0-2	D-box binding PAR bZIP transcription factor	Homo sapiens	102-105
12437334-1	2002	The potent mutagen/carcinogen benzo[a]pyrene (B[a]P) is metabolically activated to (+)-anti-B[a]PDE, which is known to induce a variety of mutations (e.g., GC --> TA, GC --> AT, etc.).	Benzo(a)pyrene	30-44	aldehyde dehydrogenase 7 family member A1	Homo sapiens	96-99
12619281-1	2002	Benzo(a) pyrene (BaP) can not be biodegraded in the soil easily, the degradation of BaP is know as a cometabolic process.	Benzo(a)pyrene	0-15	prohibitin 2	Homo sapiens	17-20
12619281-1	2002	Benzo(a) pyrene (BaP) can not be biodegraded in the soil easily, the degradation of BaP is know as a cometabolic process.	Benzo(a)pyrene	0-15	prohibitin 2	Homo sapiens	84-87
12466317-19	2002	Poor BP control may lead to excessive systemic mechanical stress at the vascular level despite satisfactory inhibition of angiotensin II effects.	Benzo(a)pyrene	5-7	angiotensinogen	Homo sapiens	122-136
12401509-1	2002	The objective of this study was to evaluate the effect of subacute exposure to inhaled benzo(a)pyrene (BaP) on fetal survival and luteal maintenance using timed-pregnant Fisher 344 rats.	Benzo(a)pyrene	87-101	prohibitin 2	Rattus norvegicus	103-106
12641979-3	2002	Also, the effects of chrysotile on the activities of CYP1A1 and GST induced by benzo(a)pyrene were studied.	Benzo(a)pyrene	79-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
12641979-3	2002	Also, the effects of chrysotile on the activities of CYP1A1 and GST induced by benzo(a)pyrene were studied.	Benzo(a)pyrene	79-93	glutathione S-transferase kappa 1	Homo sapiens	64-67
12641979-12	2002	A549 cells were incubated with chrysotile fiber for 24 h firstly, and then incubated with benzo(a)pyrene to induce the activities of EROD and GST.	Benzo(a)pyrene	90-104	glutathione S-transferase kappa 1	Homo sapiens	142-145
12641979-14	2002	However, UC at a dose of 200 mg/L and MC at 100 mg/L could increase the activity of GST induced by benzo(a)pyrene.	Benzo(a)pyrene	99-113	glutathione S-transferase kappa 1	Homo sapiens	84-87
12396873-8	2002	Treatment with 10 micro M benzo[a]pyrene, a component of MEP extract, for 24 h induced catalytic activity, protein, and mRNA of cytochromes P-450 1A1 and 1B1 in MCF-7 cells.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	140-157
12408618-8	2002	Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals.	Benzo(a)pyrene	198-201	aryl hydrocarbon receptor 1b	Oryzias latipes	95-98
12239234-8	2002	The simultaneous inhibition of ACE and NEP may be more effective in reducing BP than the inhibition of ACE alone and less dependent on sodium balance.	Benzo(a)pyrene	77-79	angiotensin I converting enzyme	Homo sapiens	31-34
12239234-8	2002	The simultaneous inhibition of ACE and NEP may be more effective in reducing BP than the inhibition of ACE alone and less dependent on sodium balance.	Benzo(a)pyrene	77-79	membrane metalloendopeptidase	Homo sapiens	39-42
12354067-6	2002	P450 1A1 substrates, such as benzo[a]pyrene, ethoxyresorufin and methoxyresorufin, were then docked into the active site of the model, and key amino acid residues able to interact with the substrate, have been identified.	Benzo(a)pyrene	29-43	solute carrier family 45 member 2	Homo sapiens	5-8
14694720-1	2002	OBJECTIVE: To explore the relation between genetic polymorphisms of NQO1, GSTT1 and risks of chronic benzene poisoning (BP).	Benzo(a)pyrene	120-122	NAD(P)H quinone dehydrogenase 1	Homo sapiens	68-72
14694720-1	2002	OBJECTIVE: To explore the relation between genetic polymorphisms of NQO1, GSTT1 and risks of chronic benzene poisoning (BP).	Benzo(a)pyrene	120-122	glutathione S-transferase theta 1	Homo sapiens	74-79
12227954-6	2002	Skin preexposure to the skin CYP450 inducer BaP largely changed label penetration depth and distribution pattern in cutaneous tissues and decreased (14)C concentration in skin and fat.	Benzo(a)pyrene	44-47	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-35
12383707-0	2002	Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 14	Homo sapiens	58-61
12383707-0	2002	Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.	Benzo(a)pyrene	0-14	crystallin zeta	Homo sapiens	147-172
12383707-4	2002	We investigated the participation of BP-induced MAP kinase activation in cell growth and increases in activity of the detoxification enzyme NAD(P)H:quinone reductase (QR).	Benzo(a)pyrene	37-39	crystallin zeta	Homo sapiens	140-165
12383707-6	2002	Inhibition of ERK eliminated BP-induced QR activity, whereas inhibition of p38 had no effect on QR activity.	Benzo(a)pyrene	29-31	mitogen-activated protein kinase 1	Homo sapiens	14-17
12383707-7	2002	Treatment of cells with 10 nM BP increased [(3)H]thyd incorporation by 50% after 48 h. This increase was eliminated by ERK but not p38 inhibition.	Benzo(a)pyrene	30-32	mitogen-activated protein kinase 1	Homo sapiens	119-122
12383707-7	2002	Treatment of cells with 10 nM BP increased [(3)H]thyd incorporation by 50% after 48 h. This increase was eliminated by ERK but not p38 inhibition.	Benzo(a)pyrene	30-32	mitogen-activated protein kinase 14	Homo sapiens	131-134
12383707-8	2002	In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity.	Benzo(a)pyrene	21-23	mitogen-activated protein kinase 1	Homo sapiens	34-37
12383707-8	2002	In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity.	Benzo(a)pyrene	21-23	mitogen-activated protein kinase 14	Homo sapiens	42-45
12383707-8	2002	In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity.	Benzo(a)pyrene	75-77	mitogen-activated protein kinase 1	Homo sapiens	56-59
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Benzo(a)pyrene	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Benzo(a)pyrene	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12205049-8	2002	3H-arachidonate release and apoptosis induced by 1-MA, B(a)P, and PA were inhibited by methylarachidonoyl-fluorophosphonate, an inhibitor of Groups IV and VI PLA2s.	Benzo(a)pyrene	55-60	phospholipase A2 group IIA	Homo sapiens	158-163
12205049-10	2002	These data suggest that 1-MA, B(a)P and PA induce apoptosis of endothelial cells by a mechanism that involves activation of these three distinct isoforms of PLA2.	Benzo(a)pyrene	30-35	phospholipase A2 group IB	Homo sapiens	157-161
12587739-1	2002	In order to determine the organ specific carcinogenicity of benzo(a)pyrene (B(a)P), its metabolites, formed in vitro by incubation with the homogenates from liver, lungs, kidneys, intestine and brain of rats, were isolated by TLC and spectroscopy.	Benzo(a)pyrene	60-74	prohibitin 2	Rattus norvegicus	76-81
12408618-8	2002	Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals.	Benzo(a)pyrene	198-201	cytochrome P450 1A1	Oryzias latipes	115-120
12408618-8	2002	Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals.	Benzo(a)pyrene	198-201	aryl hydrocarbon receptor 1b	Oryzias latipes	224-227
12408618-8	2002	Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals.	Benzo(a)pyrene	198-201	cytochrome P450 1A1	Oryzias latipes	247-252
12408618-8	2002	Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals.	Benzo(a)pyrene	285-288	aryl hydrocarbon receptor 1b	Oryzias latipes	95-98
12408618-8	2002	Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals.	Benzo(a)pyrene	285-288	aryl hydrocarbon receptor 1b	Oryzias latipes	95-98
12151310-7	2002	Six months after intratracheal instillation of benzo(a)pyrene, the tumor incidence in wild-type and CCSP-dnp53 mice was 39% and 73%, respectively.	Benzo(a)pyrene	47-61	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	100-104
12183407-4	2002	Stratified analysis and regression analysis demonstrated that race, pack-years of smoking, family history of breast cancer, and CYP1B1 genotype were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues.	Benzo(a)pyrene	188-202	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	128-134
12151310-9	2002	These results suggest that p53 function is important for protecting mice from both spontaneous and BaP-induced lung cancers.	Benzo(a)pyrene	99-102	transformation related protein 53, pseudogene	Mus musculus	27-30
12151640-1	2002	Intracellular Ca2+ oscillations induced by oxytocin and vasopressin were analyzed in a rat liver cell line (Clone 9) in order to identify mechanisms by which benzo[a]pyrene (BaP) alters Ca2+ signaling patterns in these cells.	Benzo(a)pyrene	158-172	prohibitin 2	Rattus norvegicus	174-177
12375734-0	2002	Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene.	Benzo(a)pyrene	107-121	CD4 antigen	Mus musculus	39-42
12119129-8	2002	We speculate that BaP may interact with the aryl hydrocarbon receptor (AhR) in these cells and that AhR may target activated BaP to the nucleus.	Benzo(a)pyrene	18-21	aryl hydrocarbon receptor	Rattus norvegicus	44-69
12119129-8	2002	We speculate that BaP may interact with the aryl hydrocarbon receptor (AhR) in these cells and that AhR may target activated BaP to the nucleus.	Benzo(a)pyrene	18-21	aryl hydrocarbon receptor	Rattus norvegicus	71-74
12119129-8	2002	We speculate that BaP may interact with the aryl hydrocarbon receptor (AhR) in these cells and that AhR may target activated BaP to the nucleus.	Benzo(a)pyrene	125-128	aryl hydrocarbon receptor	Rattus norvegicus	100-103
12509229-0	2002	Activities of human DNA polymerase kappa in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion.	Benzo(a)pyrene	66-80	DNA polymerase kappa	Homo sapiens	20-40
12106603-6	2002	BaP-treated cultures exhibited anchorage-independent growth and increased expression of hepatocyte growth factor mRNA and E-cadherin protein.	Benzo(a)pyrene	0-3	hepatocyte growth factor	Homo sapiens	88-112
12087061-1	2002	The developmental role of prostaglandin H synthase-2 (PHS-2), which converts xenobiotics such as benzo[a]pyrene (B[a]P) to toxic free radical intermediates, is poorly understood.	Benzo(a)pyrene	97-111	prostaglandin-endoperoxide synthase 2	Mus musculus	26-52
12087061-1	2002	The developmental role of prostaglandin H synthase-2 (PHS-2), which converts xenobiotics such as benzo[a]pyrene (B[a]P) to toxic free radical intermediates, is poorly understood.	Benzo(a)pyrene	97-111	prostaglandin-endoperoxide synthase 2	Mus musculus	54-59
12080432-6	2002	A higher BP was noted in large volume alcohol consumers having c2/c2 genotype of CYP2E1.	Benzo(a)pyrene	9-11	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	81-87
12057865-1	2002	Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl and the arylamines.	Benzo(a)pyrene	190-204	myeloperoxidase	Homo sapiens	0-15
12057865-1	2002	Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl and the arylamines.	Benzo(a)pyrene	190-204	myeloperoxidase	Homo sapiens	17-20
12052463-2	2002	Benzo(a)pyrene (BaP) and 7,12-dimethylbenz(a)anthracene (DMBA) are polycyclic aromatic hydrocarbons (PAHs) found in the tar fraction of cigarette smoke, as well as in car exhaust and furnace gases.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
12067250-1	2002	In this study, human glutathione transferases (GSTs) of alpha class have been assayed with the ultimate carcinogenic (-)-anti- and (+)-syn-diol epoxides (DEs) derived from the nonplanar dibenzo[a,l]pyrene (DBPDE) and the (+)-anti-diol epoxide of the planar benzo[a]pyrene [(+)-anti-BPDE] in the presence of glutathione (GSH).	Benzo(a)pyrene	257-271	glutathione S-transferase alpha 1	Homo sapiens	47-51
12099907-9	2002	Cocaine cue-conditioned c-fos expression was found in cortical areas, notably in the somatosensory cortex, where it was inhibited by BP 897, and in several regions belonging or linked to the limbic system.	Benzo(a)pyrene	133-135	FBJ osteosarcoma oncogene	Mus musculus	24-29
12099907-10	2002	In conditioned mice, BP 897 inhibited c-fos expression in VTA and activated it in amygdala.	Benzo(a)pyrene	21-23	FBJ osteosarcoma oncogene	Mus musculus	38-43
11981675-15	2002	The concentrations of all urinary metabolites correlated significantly with benzo[ a]pyrene (BaP) in the air.	Benzo(a)pyrene	76-91	prohibitin 2	Homo sapiens	93-96
12023681-3	2002	METHODS AND RESULTS: We genotyped the ACE I/D polymorphism in 1245 subjects with home BP and 803 subjects with ABPM in Ohasama, a rural community in Japan.	Benzo(a)pyrene	86-88	angiotensin I converting enzyme	Homo sapiens	38-41
12175492-4	2002	We demonstrate that a 254 bp derivative of a previously defined visceral mesoderm-specific enhancer element, vm1, from beta 3Tub60D contains one specific in vitro binding site for Bagpipe and two such sites for Biniou.	Benzo(a)pyrene	26-28	vm1	Drosophila melanogaster	109-112
12175492-4	2002	We demonstrate that a 254 bp derivative of a previously defined visceral mesoderm-specific enhancer element, vm1, from beta 3Tub60D contains one specific in vitro binding site for Bagpipe and two such sites for Biniou.	Benzo(a)pyrene	26-28	bagpipe	Drosophila melanogaster	180-187
12054747-3	2002	Immunocytochemistry and Western immunoblot analysis showed that BaP, but not TCDD, produced a marked loss of plasma membrane epidermal growth factor receptor (EGF-R) localized along intercellular boundaries.	Benzo(a)pyrene	64-67	epidermal growth factor receptor	Homo sapiens	125-157
12054747-3	2002	Immunocytochemistry and Western immunoblot analysis showed that BaP, but not TCDD, produced a marked loss of plasma membrane epidermal growth factor receptor (EGF-R) localized along intercellular boundaries.	Benzo(a)pyrene	64-67	epidermal growth factor receptor	Homo sapiens	159-164
12054747-4	2002	BaP-treated cells exhibited significant decreases in beta-catenin and cadherin protein levels, while vinculin levels remained unchanged relative to control.	Benzo(a)pyrene	0-3	catenin beta 1	Homo sapiens	53-65
12034312-1	2002	Co-exposures to complex mixtures of arsenic and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) are common in the environment.	Benzo(a)pyrene	89-103	prohibitin 2	Mus musculus	105-108
11891231-6	2002	Gel mobility shift assays using HepG2 or rat hepatocyte nuclear extract confirm HNF-4alpha binds between bp -375 and -360.	Benzo(a)pyrene	105-107	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	80-90
12127040-0	2002	Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	32-38
12127040-3	2002	The objective of this research was to investigate effects of cigarette smoke related hydrocarbons (benzo(a)pyrene, BP) on uterine CYP1A1/2 and 1B1, enzymes involved in estrogen metabolism.	Benzo(a)pyrene	99-113	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	130-146
12127040-3	2002	The objective of this research was to investigate effects of cigarette smoke related hydrocarbons (benzo(a)pyrene, BP) on uterine CYP1A1/2 and 1B1, enzymes involved in estrogen metabolism.	Benzo(a)pyrene	115-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	130-146
12127040-9	2002	Low level of constitutive CYP1 activity was observed in RL95-2 cells, which was significantly induced by BP exposure (12-fold at 1mM).	Benzo(a)pyrene	105-107	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-30
12127040-10	2002	CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM).	Benzo(a)pyrene	17-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-4
12127040-10	2002	CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM).	Benzo(a)pyrene	17-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
12127040-10	2002	CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM).	Benzo(a)pyrene	17-19	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	193-199
12127040-12	2002	It also appears that CYP1A1 is one of the major CYP450 enzymes induced by BP.	Benzo(a)pyrene	74-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
11952781-2	2002	Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons.	Benzo(a)pyrene	117-131	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-24
11849738-2	2002	CYP1A1 transcripts were present in all of the lung specimens and were induced by the prototypic inducers 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), and by the atypical inducers pyridine, nicotine, and omeprazole.	Benzo(a)pyrene	152-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
11929814-0	2002	Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.	Benzo(a)pyrene	20-34	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	118-145
11929814-1	2002	UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of benzo(a)pyrene-trans-7,8-dihydrodiol (BPD), precursor to the potent mutagen benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide, may be an important pathway in the detoxification of benzo(a)pyrene.	Benzo(a)pyrene	62-76	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-27
11929814-1	2002	UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of benzo(a)pyrene-trans-7,8-dihydrodiol (BPD), precursor to the potent mutagen benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide, may be an important pathway in the detoxification of benzo(a)pyrene.	Benzo(a)pyrene	62-76	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	29-32
11951953-1	2002	The interaction of the chemical carcinogen benzo[a]pyrene (BaP) with phosphatidylcholine membranes has been investigated by using various physical techniques.	Benzo(a)pyrene	43-57	prohibitin 2	Homo sapiens	59-62
11952781-2	2002	Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons.	Benzo(a)pyrene	117-131	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
11884429-3	2002	Exposure to BP during monocyte differentiation into DC upon the action of GM-CSF and IL-4 markedly inhibited the up-regulation of markers found in DC such as CD1a, CD80, and CD40, without altering cell viability.	Benzo(a)pyrene	12-14	colony stimulating factor 2	Homo sapiens	74-80
12076095-5	2002	BaP induced the expression of a phase I drug metabolizing enzyme which was identified as cytochrome P450 1A1 (CYP 1A1) by RT-PCR and by Western blotting.	Benzo(a)pyrene	0-3	cytochrome P450 1A1	Bos taurus	89-108
12076095-5	2002	BaP induced the expression of a phase I drug metabolizing enzyme which was identified as cytochrome P450 1A1 (CYP 1A1) by RT-PCR and by Western blotting.	Benzo(a)pyrene	0-3	cytochrome P450 1A1	Bos taurus	110-117
11884429-3	2002	Exposure to BP during monocyte differentiation into DC upon the action of GM-CSF and IL-4 markedly inhibited the up-regulation of markers found in DC such as CD1a, CD80, and CD40, without altering cell viability.	Benzo(a)pyrene	12-14	interleukin 4	Homo sapiens	85-89
11884429-3	2002	Exposure to BP during monocyte differentiation into DC upon the action of GM-CSF and IL-4 markedly inhibited the up-regulation of markers found in DC such as CD1a, CD80, and CD40, without altering cell viability.	Benzo(a)pyrene	12-14	CD1a molecule	Homo sapiens	158-162
11884429-3	2002	Exposure to BP during monocyte differentiation into DC upon the action of GM-CSF and IL-4 markedly inhibited the up-regulation of markers found in DC such as CD1a, CD80, and CD40, without altering cell viability.	Benzo(a)pyrene	12-14	CD80 molecule	Homo sapiens	164-168
11884429-3	2002	Exposure to BP during monocyte differentiation into DC upon the action of GM-CSF and IL-4 markedly inhibited the up-regulation of markers found in DC such as CD1a, CD80, and CD40, without altering cell viability.	Benzo(a)pyrene	12-14	CD40 molecule	Homo sapiens	174-178
11884429-6	2002	Features of LPS-mediated maturation of DC, such as CD83 up-regulation and IL-12 secretion, were also impaired in response to BP treatment.	Benzo(a)pyrene	125-127	CD83 molecule	Homo sapiens	51-55
11856577-7	2002	Results demonstrated that in the absence of effects upon host survival or condition factors, a single exposure to a relatively low dose of BaP (2 microg/g BW) significantly suppressed mitogen-stimulated T- and B-lymphocyte proliferation (in the absence of elevated hepatic CYP1A expression/activity).	Benzo(a)pyrene	139-142	cytochrome P450 1A1	Oryzias latipes	273-278
11782367-0	2002	Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.	Benzo(a)pyrene	147-161	BRCA1 DNA repair associated	Homo sapiens	108-114
11854143-0	2002	Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.	Benzo(a)pyrene	69-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
11854143-0	2002	Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.	Benzo(a)pyrene	69-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
11854143-2	2002	We examined the effects of NaAsO(2) in combination with benzo[a]pyrene (BAP) on CYP1A1 and CYP1B1 in T-47D human breast cancer cells by using estrogen metabolism as a probe of their activities.	Benzo(a)pyrene	56-70	prohibitin 2	Homo sapiens	72-75
11854143-2	2002	We examined the effects of NaAsO(2) in combination with benzo[a]pyrene (BAP) on CYP1A1 and CYP1B1 in T-47D human breast cancer cells by using estrogen metabolism as a probe of their activities.	Benzo(a)pyrene	56-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
11999442-11	2002	Testicular expression of estrogen receptor (ER)-alpha and ER-beta mRNA was significantly increased in 200 mg/kg of BP treated group at PND 90.	Benzo(a)pyrene	115-117	estrogen receptor 1	Rattus norvegicus	25-53
11999442-11	2002	Testicular expression of estrogen receptor (ER)-alpha and ER-beta mRNA was significantly increased in 200 mg/kg of BP treated group at PND 90.	Benzo(a)pyrene	115-117	estrogen receptor 2	Rattus norvegicus	58-65
11911489-1	2002	Both simultaneous and sequential exposure to arsenite and benzo[a]pyrene (BaP) potentially occur in human populations drinking arsenic-contaminated water or burning arsenic-contaminated coal.	Benzo(a)pyrene	58-72	prohibitin 2	Homo sapiens	74-77
11782367-2	2002	In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 mRNA levels in breast cancer MCF-7 cells.	Benzo(a)pyrene	89-103	BRCA1 DNA repair associated	Homo sapiens	120-126
11921194-4	2002	We report that benzo[a]pyrene (B[a]P), selected as a prototype PAH, disrupts BRCA-1 transcription in estrogen receptor (ER)-positive but not ER-negative breast cancer cells.	Benzo(a)pyrene	15-29	BRCA1 DNA repair associated	Homo sapiens	77-83
11921196-7	2002	Interestingly, endogenous 17beta-estradiol (E(2)) is metabolized by the cytochrome P450 enzyme isoforms CYP1A1 and CYP1B1, which also activate benzo[a]pyrene (B[a]P), a carcinogen contained in cigarette smoke.	Benzo(a)pyrene	143-157	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
11921196-7	2002	Interestingly, endogenous 17beta-estradiol (E(2)) is metabolized by the cytochrome P450 enzyme isoforms CYP1A1 and CYP1B1, which also activate benzo[a]pyrene (B[a]P), a carcinogen contained in cigarette smoke.	Benzo(a)pyrene	143-157	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	115-121
11807932-2	2002	The potency of PAH mixtures often is calculated using relative potency values (BAP equivalency factors).	Benzo(a)pyrene	79-82	phenylalanine hydroxylase	Homo sapiens	15-18
11807932-5	2002	Moreover, when the PAH composition of the mixture has been analysed, prediction of the potency of PAH mixtures by BAP equivalency factors could be compared with the observed PAH potency.	Benzo(a)pyrene	114-117	phenylalanine hydroxylase	Homo sapiens	19-22
11807932-5	2002	Moreover, when the PAH composition of the mixture has been analysed, prediction of the potency of PAH mixtures by BAP equivalency factors could be compared with the observed PAH potency.	Benzo(a)pyrene	114-117	phenylalanine hydroxylase	Homo sapiens	98-101
11807932-5	2002	Moreover, when the PAH composition of the mixture has been analysed, prediction of the potency of PAH mixtures by BAP equivalency factors could be compared with the observed PAH potency.	Benzo(a)pyrene	114-117	phenylalanine hydroxylase	Homo sapiens	98-101
11807932-7	2002	Evaluation of several studies with various PAH mixtures revealed that the potency ratio between pure BAP and the PAH mixture in the same assay is highly dependent on the exposure pathway and the target organ, therefore potency estimates for PAH mixtures should be derived separately for oral, dermal and inhalative exposure using data from studies with the relevant pathway.	Benzo(a)pyrene	101-104	phenylalanine hydroxylase	Homo sapiens	43-46
11807932-7	2002	Evaluation of several studies with various PAH mixtures revealed that the potency ratio between pure BAP and the PAH mixture in the same assay is highly dependent on the exposure pathway and the target organ, therefore potency estimates for PAH mixtures should be derived separately for oral, dermal and inhalative exposure using data from studies with the relevant pathway.	Benzo(a)pyrene	101-104	phenylalanine hydroxylase	Homo sapiens	113-116
11807932-7	2002	Evaluation of several studies with various PAH mixtures revealed that the potency ratio between pure BAP and the PAH mixture in the same assay is highly dependent on the exposure pathway and the target organ, therefore potency estimates for PAH mixtures should be derived separately for oral, dermal and inhalative exposure using data from studies with the relevant pathway.	Benzo(a)pyrene	101-104	phenylalanine hydroxylase	Homo sapiens	113-116
11807932-9	2002	By using incidence data for all exposure-related tumours, a slope factor for humans of 11.5 (human excess risk per oral lifetime exposure with 1 mg BAP kg(-1)day(-1) in a PAH mixture) was obtained.	Benzo(a)pyrene	148-151	phenylalanine hydroxylase	Homo sapiens	171-174
11807932-10	2002	Our analysis led to the conclusion that the contribution of BAP to the carcinogenic potency of the mixture depends on the exposure pathway and type of cancer observed but is relatively constant for various PAH mixtures from industrial sources.	Benzo(a)pyrene	60-63	phenylalanine hydroxylase	Homo sapiens	206-209
11752233-5	2002	Likewise, DNA damage (SB and DNA adducts) was elevated in V79 h1A1-MZ cells expressing human CYP1A1 when treated with BaP (0.1-0.5 microM) and this was inhibited by chrysin and apigenin, but not by quercetin.	Benzo(a)pyrene	118-121	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
11741297-0	2001	Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	59-65
11741297-0	2001	Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	110-113
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-52
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	54-60
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	63-69
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	prohibitin 2	Mus musculus	152-155
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	prohibitin 2	Mus musculus	238-241
11742250-3	2001	The DAT, a predominantly presynaptic receptor, decreases in density after chronic dopamine depletion and the BP is proportional to receptor density.	Benzo(a)pyrene	109-111	solute carrier family 6 member 3	Homo sapiens	4-7
11742250-7	2001	Lower DAT BP itself reduces extracellular clearance of dopamine.	Benzo(a)pyrene	10-12	solute carrier family 6 member 3	Homo sapiens	6-9
11755119-3	2001	Baicalein added in vitro decreased liver microsomal benzo[a]pyrene hydroxylation (AHH) activity with an ic(50) of 33.9 +/- 1.4 microM at 100 microM benzo[a]pyrene.	Benzo(a)pyrene	52-66	aryl-hydrocarbon receptor	Mus musculus	82-85
11682644-8	2001	When tested in the Ames test, Aroclor S9 and PB/NF S9 were the most effective in the activation of benzo[a]pyrene and 3-methylcholanthrene which are metabolized mainly by CYP1A1; additionally, the highest mutagenic potency of 2-aminofluorene and N-nitrosodipropylamine, which are activated by CYP1A2 and CYP2B, respectively, were obtained with PB/NF S9.	Benzo(a)pyrene	99-113	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	171-177
11754570-6	2002	Furthermore, when HepG2 cells were pretreated with omeprazole to induce CYP1A1, then exposed to benzo[a]pyrene (B[a]P), DNA damage was observed using the comet assay.	Benzo(a)pyrene	96-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78
11749126-1	2001	Certainpolynuclear aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) induce CYP1A-dependent enzyme activities.	Benzo(a)pyrene	56-70	cytochrome P450 1A1	Fundulus heteroclitus	84-89
11749126-1	2001	Certainpolynuclear aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) induce CYP1A-dependent enzyme activities.	Benzo(a)pyrene	72-75	cytochrome P450 1A1	Fundulus heteroclitus	84-89
11794536-4	2001	The fecal beta-glucuronidase activity of human intestinal bacteria was drastically induced by its substrate or the bile secreted after a subcutaneous injection of 1,2-dimethylhydrazine (DMH) and benzo[a]pyrene into rats.	Benzo(a)pyrene	195-209	glucuronidase beta	Homo sapiens	10-28
11794536-5	2001	DMH- and benzo[a]pyrene-treated biles induced beta-glucuronidase activity in the human intestinal microflora by approximately 1.5- and 2.3-fold, respectively.	Benzo(a)pyrene	9-23	glucuronidase beta	Homo sapiens	46-64
11737050-6	2001	IL-10 was further evaluated using benzo[a]pyrene and [alpha]naphthoflavone as a surrogate for the polyaromatic hydrocarbons (PAHs) adsorbed to DEP.	Benzo(a)pyrene	34-48	interleukin 10	Homo sapiens	0-5
11737050-11	2001	These effects on IL-10 are reproduced with benzo[a]pyrene and reversed by the coaddition of [alpha]naphthoflavone, its known antagonist.	Benzo(a)pyrene	43-57	interleukin 10	Homo sapiens	17-22
11764156-9	2001	On the other hand, azaarenes showed a strong AhR-mediated activity, with dibenzo[a,h]acridine being a far more potent inducer of activity than benzo[a]pyrene.	Benzo(a)pyrene	143-157	aryl hydrocarbon receptor	Homo sapiens	45-48
11751711-2	2001	They suggested that G/T polymorphism of ET-1 strongly interacted with body mass index (BMI) in the determination of BP levels.	Benzo(a)pyrene	116-118	endothelin 1	Homo sapiens	40-44
11751711-10	2001	That similar results were obtained from subjects of different races suggests that the Lys198Asn polymorphism of ET-1 is involved in determination of BP levels in obese subjects.	Benzo(a)pyrene	149-151	endothelin 1	Homo sapiens	112-116
11597790-1	2001	Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE).	Benzo(a)pyrene	90-104	epoxide hydrolase 1	Homo sapiens	6-34
11597790-1	2001	Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE).	Benzo(a)pyrene	90-104	epoxide hydrolase 1, microsomal	Mus musculus	36-39
11768202-7	2001	BP treatment reduced BGP levels to values significantly lower than SHAM rats (P < 0.05) and reduced bone alkaline phosphatase in SHAM groups (P < 0.05) but no changes were found in OVX groups.	Benzo(a)pyrene	0-2	bone gamma-carboxyglutamate protein	Rattus norvegicus	21-24
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	82-106
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	108-111
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	82-106
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	108-111
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Benzo(a)pyrene	248-253	aryl-hydrocarbon receptor	Mus musculus	82-106
11733032-3	2001	Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin.	Benzo(a)pyrene	248-253	aryl-hydrocarbon receptor	Mus musculus	108-111
11733032-8	2001	Thus, polkappa seems to function to reduce mutagenesis at benzo[a]pyrene-adducts, although it may also have a role related to spermatogenesis.	Benzo(a)pyrene	58-72	DNA polymerase lambda	Homo sapiens	6-14
11682644-8	2001	When tested in the Ames test, Aroclor S9 and PB/NF S9 were the most effective in the activation of benzo[a]pyrene and 3-methylcholanthrene which are metabolized mainly by CYP1A1; additionally, the highest mutagenic potency of 2-aminofluorene and N-nitrosodipropylamine, which are activated by CYP1A2 and CYP2B, respectively, were obtained with PB/NF S9.	Benzo(a)pyrene	99-113	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	293-299
11564864-6	2001	Finally, a preferential caspase inhibitor, Z-Asp-CH2-DCB, strongly blocked the alphaPIX (Delta CH)-enhanced apoptosis in cells treated with B(a)P but did not block PAK1/JNK1 activation.	Benzo(a)pyrene	140-145	Rac/Cdc42 guanine nucleotide exchange factor 6	Homo sapiens	79-87
11564864-0	2001	Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.	Benzo(a)pyrene	131-145	Rac/Cdc42 guanine nucleotide exchange factor 6	Homo sapiens	15-52
11564864-0	2001	Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.	Benzo(a)pyrene	131-145	p21 (RAC1) activated kinase 1	Homo sapiens	60-64
11564864-0	2001	Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.	Benzo(a)pyrene	131-145	mitogen-activated protein kinase 8	Homo sapiens	65-94
11564864-1	2001	Benzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH(2)-terminal kinase 1 (JNK1) and induce caspase-3-mediated apoptosis in Hepa1c1c7 cells.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 8	Mus musculus	160-189
11564864-1	2001	Benzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH(2)-terminal kinase 1 (JNK1) and induce caspase-3-mediated apoptosis in Hepa1c1c7 cells.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 8	Mus musculus	191-195
11564864-1	2001	Benzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH(2)-terminal kinase 1 (JNK1) and induce caspase-3-mediated apoptosis in Hepa1c1c7 cells.	Benzo(a)pyrene	0-14	caspase 3	Mus musculus	208-217
11564864-1	2001	Benzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH(2)-terminal kinase 1 (JNK1) and induce caspase-3-mediated apoptosis in Hepa1c1c7 cells.	Benzo(a)pyrene	16-21	mitogen-activated protein kinase 8	Mus musculus	160-189
11564864-1	2001	Benzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH(2)-terminal kinase 1 (JNK1) and induce caspase-3-mediated apoptosis in Hepa1c1c7 cells.	Benzo(a)pyrene	16-21	mitogen-activated protein kinase 8	Mus musculus	191-195
11564864-1	2001	Benzo[a]pyrene [B(a)P], a potent procarcinogen found in combustion products such as diesel exhaust and cigarette smoke, has been recently shown to activate the c-Jun NH(2)-terminal kinase 1 (JNK1) and induce caspase-3-mediated apoptosis in Hepa1c1c7 cells.	Benzo(a)pyrene	16-21	caspase 3	Mus musculus	208-217
11564581-14	2001	The risk of CYP1A1 can be supported by the functional difference between presence of valine and isoleucine; valine type has higher catalytic and mutagenic activity towards benzo[a] pyrene than the isoleucine type.	Benzo(a)pyrene	172-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-18
11485833-5	2001	S(9) fractions from the tissues catalyzed the bioactivation of benzo[a]pyrene (B[a]P), a CYP1A1-preferential activity, to mutagens in the Ames assay.	Benzo(a)pyrene	63-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	89-95
11577022-4	2001	Although Cyp1a1 was inducible in Ahr(+/+) by 3 micromol/L benzo(a)pyrene, a known hydrocarbon inducer, the protein was uninducible.	Benzo(a)pyrene	58-72	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	9-15
11577022-4	2001	Although Cyp1a1 was inducible in Ahr(+/+) by 3 micromol/L benzo(a)pyrene, a known hydrocarbon inducer, the protein was uninducible.	Benzo(a)pyrene	58-72	aryl-hydrocarbon receptor	Mus musculus	33-36
11577022-6	2001	CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs.	Benzo(a)pyrene	124-138	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-3
11577022-6	2001	CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs.	Benzo(a)pyrene	124-138	aryl-hydrocarbon receptor	Mus musculus	64-67
11577022-6	2001	CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs.	Benzo(a)pyrene	124-138	aryl-hydrocarbon receptor	Mus musculus	142-145
11577022-6	2001	CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs.	Benzo(a)pyrene	124-138	aryl-hydrocarbon receptor	Mus musculus	142-145
11583143-3	2001	This rise in BP corresponds to increased secretion of catecholamines and increased plasma renin activity.	Benzo(a)pyrene	13-15	renin	Homo sapiens	90-95
11522624-3	2001	In the present study, we have used a highly sensitive mutation assay to determine the p53 mutation load in nontumorous human lung and to study the mutability of p53 codons 157, 248, 249, and 250 to benzo(a)pyrene-diol-epoxide (BPDE), an active metabolite of BP in human bronchial epithelial BEAS-2B cells.	Benzo(a)pyrene	227-229	tumor protein p53	Homo sapiens	161-164
11522624-13	2001	These data are consistent with the hypothesis that chemical carcinogens such as BP in cigarette smoke cause G:C to T:A transversions at p53 codons 157, 248, and 249 and that nontumorous lung tissues from smokers with lung cancer carry a high p53 mutational load at these codons.	Benzo(a)pyrene	80-82	tumor protein p53	Homo sapiens	136-139
11522624-13	2001	These data are consistent with the hypothesis that chemical carcinogens such as BP in cigarette smoke cause G:C to T:A transversions at p53 codons 157, 248, and 249 and that nontumorous lung tissues from smokers with lung cancer carry a high p53 mutational load at these codons.	Benzo(a)pyrene	80-82	tumor protein p53	Homo sapiens	242-245
11800308-2	2001	Adequacy of BP management (ADBP) was considered when DBP < 85 mmHg in diabetic patients with HT or < 90 mmHg in non-diabetic EHT.	Benzo(a)pyrene	12-14	D-box binding PAR bZIP transcription factor	Homo sapiens	28-31
11506808-1	2001	We assessed the ability of green tea to protect against benzo[a]pyrene (B[a]P)-induced mutations in the liver of lacI transgenic male C57BL/6 Big Blue mice.	Benzo(a)pyrene	56-70	tissue factor pathway inhibitor	Mus musculus	113-117
11780955-0	2001	Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene.	Benzo(a)pyrene	116-130	aryl-hydrocarbon receptor	Mus musculus	23-48
11780955-1	2001	Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	25-50
11780955-1	2001	Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	52-55
11780955-1	2001	Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction.	Benzo(a)pyrene	16-19	aryl-hydrocarbon receptor	Mus musculus	25-50
11780955-1	2001	Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction.	Benzo(a)pyrene	16-19	aryl-hydrocarbon receptor	Mus musculus	52-55
11780955-2	2001	We hypothesized that BaP damages sperm through AhR activation, phase I enzyme induction, DNA adduct formation, and increased germ cell apoptosis in the testis, and that resveratrol, a natural competitive inhibitor of the AhR found in some red wines, could prevent the adverse effects of BaP on sperm.	Benzo(a)pyrene	21-24	aryl-hydrocarbon receptor	Mus musculus	47-50
11780955-2	2001	We hypothesized that BaP damages sperm through AhR activation, phase I enzyme induction, DNA adduct formation, and increased germ cell apoptosis in the testis, and that resveratrol, a natural competitive inhibitor of the AhR found in some red wines, could prevent the adverse effects of BaP on sperm.	Benzo(a)pyrene	21-24	aryl-hydrocarbon receptor	Mus musculus	221-224
11780955-2	2001	We hypothesized that BaP damages sperm through AhR activation, phase I enzyme induction, DNA adduct formation, and increased germ cell apoptosis in the testis, and that resveratrol, a natural competitive inhibitor of the AhR found in some red wines, could prevent the adverse effects of BaP on sperm.	Benzo(a)pyrene	287-290	aryl-hydrocarbon receptor	Mus musculus	221-224
11452587-1	2001	The main aim of this work was the analyzing of the release to the atmosphere of benzo[a]pyrene (BaP), dibenzo(a,h)anthracene (D(a,h)A), and benzo[a]anthracene (BaA), three of the most carcinogenic PAHs listed by US-EPA as priority pollutants, emitted from combustion at the last generation reactors used nowadays in power generation, fluidized bed reactors, trying to establish their incidence when waste materials are used as "new fuels".	Benzo(a)pyrene	80-94	prohibitin 2	Homo sapiens	96-99
11780955-14	2001	The natural AhR antagonist, resveratrol diminished BaP-induced DNA adducts and apoptosis in seminiferous tubules.	Benzo(a)pyrene	51-54	aryl-hydrocarbon receptor	Mus musculus	12-15
11470762-1	2001	Murine class Alpha glutathione (GSH) transferase A1-1 (mGSTA1-1) is unique among mammalian Alpha class GSTs due to its exceptionally high catalytic activity toward (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE], which is the activated metabolite of an environmentally relevant carcinogen, benzo[a] pyrene (BP).	Benzo(a)pyrene	326-341	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	55-63
11470762-1	2001	Murine class Alpha glutathione (GSH) transferase A1-1 (mGSTA1-1) is unique among mammalian Alpha class GSTs due to its exceptionally high catalytic activity toward (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE], which is the activated metabolite of an environmentally relevant carcinogen, benzo[a] pyrene (BP).	Benzo(a)pyrene	242-244	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	55-63
11423564-5	2001	These results demonstrate, for the first time in vivo, that the renal AT(1) receptor is inversely related to the activity of the renin angiotensin system, which may provide a compensatory mechanism to prevent inappropriate fluctuations in arterial BP.	Benzo(a)pyrene	248-250	renin	Homo sapiens	129-134
11458987-0	2001	Organ-specific differences in 8-oxoguanosine glycosylase (OGG1) repair following acute treatment with benzo[a]pyrene.	Benzo(a)pyrene	102-116	8-oxoguanine DNA glycosylase	Rattus norvegicus	58-62
11437649-3	2001	Exposure to certain chemicals, such as 3-methylcholanthrene, benzo[a]pyrene, beta-naphthoflavone, and oltipraz elevates UGT1A6 mRNA in liver and to a lesser extent gastrointestinal tract and kidney, but not in other tissues.	Benzo(a)pyrene	61-75	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	120-126
11375902-2	2001	Mouse embryo C3H/10T1/2 fibroblasts pre-treated with benzo[a] pyrene, developed transformed foci on exposure to free radical generators, such as 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH) and 3-morpholinosydnonimine hydrochloride (SIN-1).	Benzo(a)pyrene	53-68	mitogen-activated protein kinase associated protein 1	Mus musculus	241-246
11304416-2	2001	The present study has shown that exposure of washed bovine platelets to subthreshold concentrations of adenosine diphosphate or thrombin before stirring restores their sensitivity to BP, and the cells undergo rapid agglutination.	Benzo(a)pyrene	183-185	coagulation factor II, thrombin	Bos taurus	128-136
11346483-6	2001	Pretreatment of rats with 1% turmeric through the diet resulted in a significant decrease in induction of B(a)P-induced CYP 1A1 and 1A2 and phenobarbitone (PB)-induced CYP 2B1 in liver, lung and stomach, although the extent of the decrease was different.	Benzo(a)pyrene	106-111	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	120-127
11468695-3	2001	The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C-->T:A point mutations.	Benzo(a)pyrene	126-140	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-47
11358313-1	2001	After multiple ethanol washings followed by distillation, concentrated benzo(a)pyrene (B(a)P) in ethanol (approximately 85 mg L(-1)) was treated by Fenton oxidation, where > 99.8% of B(a)P was removed under a pseudo-first-order reaction.	Benzo(a)pyrene	71-85	prohibitin 2	Homo sapiens	87-92
11358313-1	2001	After multiple ethanol washings followed by distillation, concentrated benzo(a)pyrene (B(a)P) in ethanol (approximately 85 mg L(-1)) was treated by Fenton oxidation, where > 99.8% of B(a)P was removed under a pseudo-first-order reaction.	Benzo(a)pyrene	71-85	prohibitin 2	Homo sapiens	186-191
11513247-10	2001	All three CYP1A1 variants were active in metabolizing the precarcinogen benzo[a]pyrene (B[a]P), with wild-type enzyme showing the highest activity, followed by CYP1A1.4 (60%) and CYP1A1.2 (40%).	Benzo(a)pyrene	72-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	10-16
11513247-10	2001	All three CYP1A1 variants were active in metabolizing the precarcinogen benzo[a]pyrene (B[a]P), with wild-type enzyme showing the highest activity, followed by CYP1A1.4 (60%) and CYP1A1.2 (40%).	Benzo(a)pyrene	72-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166
11513247-10	2001	All three CYP1A1 variants were active in metabolizing the precarcinogen benzo[a]pyrene (B[a]P), with wild-type enzyme showing the highest activity, followed by CYP1A1.4 (60%) and CYP1A1.2 (40%).	Benzo(a)pyrene	72-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166
12761920-6	2001	RESULTS: beta-actin immunoreactivity of BP changed significantly after treatment with gentamicin.	Benzo(a)pyrene	40-42	actin, beta	Gallus gallus	9-19
11323393-7	2001	Dogs were exposed by inhalation to an aerosol bolus of the soot-adsorbed BAP: Following deposition in the alveolar region a fraction of BaP was rapidly desorbed from the soot and quickly absorbed into the circulation.	Benzo(a)pyrene	136-139	prohibitin 2	Homo sapiens	73-76
11513080-6	2001	Expression of CYP 1A1 and 1A2 messenger ribonucleic acid by the cells was induced by treatment with benz[a]pyrene, 3-methylcholanthrene, and benz[a]anthracene.	Benzo(a)pyrene	100-113	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-21
11293327-4	2001	This preliminary study was conducted to investigate the effects of a binary mixture of BaP and DBC on lung carcinogenicity in the strain A/J mouse as manifested by tumor development and mutations in the K-ras gene.	Benzo(a)pyrene	87-90	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	203-208
11293327-8	2001	The frequency of tumors with K-ras mutations was also less in a sample of the 10 DBC:100 BaP treatment group than in the same-dose, single compound-treated animals.	Benzo(a)pyrene	89-92	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	29-34
11274244-4	2001	Angiotensin II receptor antagonists therefore could not only control BP but also reduce TGF-beta(1) production in renal transplant patients.	Benzo(a)pyrene	69-71	angiotensinogen	Homo sapiens	0-14
11257062-4	2001	Moreover, in an analysis using the seven studies that reported measuring levels of benzo[a]pyrene (B(a)P), a typical marker of exposure, DNA adduct levels in exposed workers (versus those in referents) were significantly correlated with air levels of B(a)P.	Benzo(a)pyrene	83-97	prohibitin 2	Homo sapiens	99-104
11274226-4	2001	BP in the ACEI- and AT1R-Ant-treated groups remained significantly decreased, compared with the untreated and hydralazine-treated groups.	Benzo(a)pyrene	0-2	angiotensin II receptor, type 1a	Rattus norvegicus	20-24
11257062-4	2001	Moreover, in an analysis using the seven studies that reported measuring levels of benzo[a]pyrene (B(a)P), a typical marker of exposure, DNA adduct levels in exposed workers (versus those in referents) were significantly correlated with air levels of B(a)P.	Benzo(a)pyrene	83-97	prohibitin 2	Homo sapiens	251-256
11166912-5	2001	S9 fractions from the tissues catalyzed the bioactivation of benzo[a]pyrene (B[a]P), a CYP1A1-preferential activity, to mutagens in the Ames assay.	Benzo(a)pyrene	61-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
11248092-6	2001	In parallel with the enzymatic changes, nrf2-deficient mice had a significantly higher burden of gastric neoplasia after treatment with benzo[a]pyrene than did wild-type mice.	Benzo(a)pyrene	136-150	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
11239493-3	2001	The CYP1A1 gene is highly inducible by the environmental contaminants dioxin and benzo[a]pyrene.	Benzo(a)pyrene	81-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	4-10
11238186-0	2001	Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants.	Benzo(a)pyrene	27-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-92
11238186-1	2001	Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens.	Benzo(a)pyrene	88-102	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
11238186-1	2001	Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens.	Benzo(a)pyrene	88-102	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
11325079-1	2001	To evaluate the optimal BP control for patients with IgA nephropathy (IgAN) based on the histologic severity of the nephropathy and the degree of renal dysfunction.	Benzo(a)pyrene	24-26	IGAN1	Homo sapiens	70-74
11325079-9	2001	The optimal BP proposed by the WHO in 1999 prevents histologic evidence of renal damage for patients with IgAN.	Benzo(a)pyrene	12-14	IGAN1	Homo sapiens	106-110
11465393-0	2001	Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432.	Benzo(a)pyrene	37-51	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	83-101
11465393-10	2001	In contrast, Leu432 forms of CYP1B1 showed higher rates of oxidation of benzo[a]pyrene (to the 7,8-dihydoxy-7,8-dihydrodiol in the presence of epoxide hydrolase) than did the Val432 forms.	Benzo(a)pyrene	72-86	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	29-35
11465393-12	2001	These results suggest that polymorphic human CYP1B1 variants may cause some altered catalytic specificity with 17beta-oestradiol and benzo[a]pyrene and may influence susceptibilities of individuals towards endogenous and exogenous carcinogens.	Benzo(a)pyrene	133-147	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	45-51
11096091-0	2001	Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells.	Benzo(a)pyrene	162-176	aryl-hydrocarbon receptor	Mus musculus	31-34
11096091-0	2001	Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells.	Benzo(a)pyrene	162-176	aryl-hydrocarbon receptor	Mus musculus	36-39
11096091-0	2001	Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells.	Benzo(a)pyrene	162-176	transformation related protein 53, pseudogene	Mus musculus	66-69
11096091-0	2001	Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells.	Benzo(a)pyrene	162-176	malic enzyme complex, mitochondrial	Mus musculus	124-128
11096091-8	2001	Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	54-57
11096091-8	2001	Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	133-136
11096091-8	2001	Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor nuclear translocator	Mus musculus	137-141
11096091-8	2001	Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription.	Benzo(a)pyrene	0-14	transformation related protein 53, pseudogene	Mus musculus	158-161
11096091-8	2001	Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription.	Benzo(a)pyrene	0-14	malic enzyme complex, mitochondrial	Mus musculus	174-178
11096091-10	2001	These results indicate that the transcriptional induction of mdr1 by 3-MC and benzo(a)pyrene is directly mediated by p53 but that the metabolic activation of these compounds into reactive species is necessary to trigger p53 activation.	Benzo(a)pyrene	78-92	malic enzyme complex, mitochondrial	Mus musculus	61-65
11096091-10	2001	These results indicate that the transcriptional induction of mdr1 by 3-MC and benzo(a)pyrene is directly mediated by p53 but that the metabolic activation of these compounds into reactive species is necessary to trigger p53 activation.	Benzo(a)pyrene	78-92	transformation related protein 53, pseudogene	Mus musculus	117-120
11258965-14	2001	Nonetheless, the N(2) adducts derived from 2,6-diMeA and benzo[a]pyrene were both labeled with higher efficiencies than the C8 adduct derived from 2,6-diMeA, with the benzo[a]pyrene adduct being the best substrate for PNK.	Benzo(a)pyrene	57-71	polynucleotide kinase 3'-phosphatase	Homo sapiens	218-221
11270659-2	2001	Benzo[a]pyrene (BaP), a prototypical member of this class of chemicals, has been extensively studied for its toxic effects in laboratory animals and human populations.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
23886312-5	2001	Retene was as potent as benzo[a]pyrene in inducing RGS, but was not as readily biotransformed by the cells.	Benzo(a)pyrene	24-38	paired like homeodomain 2	Homo sapiens	51-54
11160638-5	2001	Additionally, anthracene and benzo[a]pyrene are both metabolized by CYP2F2 (0.14 +/- 0.04 and 0.04 +/- 0.00 nmol/nmol/min, respectively), albeit at much lower rates.	Benzo(a)pyrene	29-43	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	68-74
11158716-0	2001	Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo.	Benzo(a)pyrene	13-27	estrogen receptor 1	Homo sapiens	69-86
11164984-2	2001	The aim of this study was to elucidate the role of the GSTM1 genotype in protection against oxidant chemicals by comparing the sensitivity, genotoxicity and cytotoxicity of lymphocytes to benzo(a)pyrene (BaP)- and cumene hydroperoxide (CumOOH)-induced in vitro oxidative challenge.	Benzo(a)pyrene	188-202	glutathione S-transferase mu 1	Homo sapiens	55-60
11164984-2	2001	The aim of this study was to elucidate the role of the GSTM1 genotype in protection against oxidant chemicals by comparing the sensitivity, genotoxicity and cytotoxicity of lymphocytes to benzo(a)pyrene (BaP)- and cumene hydroperoxide (CumOOH)-induced in vitro oxidative challenge.	Benzo(a)pyrene	204-207	glutathione S-transferase mu 1	Homo sapiens	55-60
11164984-4	2001	Following supplementation with BaP or CumOOH, time-dependent increases were observed in the production of all the markers after incubation for 12-48 h. However, we could not find any differences between GSTM1 null and positive genotypes.	Benzo(a)pyrene	31-34	glutathione S-transferase mu 1	Homo sapiens	203-208
11164984-5	2001	Furthermore, dose or time response experiments indicated that GSTM1-deficient cells were not more sensitive than control cells to BaP-or CumOOH-induced cell killing and micronucleus formation, although they were hypersensitive to BaP-inhibited cellular growth.	Benzo(a)pyrene	230-233	glutathione S-transferase mu 1	Homo sapiens	62-67
11162773-2	2001	The effect of As, Pb, Hg, or Cd (ranked as the most hazardous environmental metals by EPA and ATSDR) on CYP1A1 and 1A2 induction by benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), dibenzo[a,h]anthracene (DBahA), benzo[a]anthracene (BaA), and benzo[k]fluoranthene (BkF) has thus been investigated in fresh human hepatocyte cultures.	Benzo(a)pyrene	132-146	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
11162773-2	2001	The effect of As, Pb, Hg, or Cd (ranked as the most hazardous environmental metals by EPA and ATSDR) on CYP1A1 and 1A2 induction by benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), dibenzo[a,h]anthracene (DBahA), benzo[a]anthracene (BaA), and benzo[k]fluoranthene (BkF) has thus been investigated in fresh human hepatocyte cultures.	Benzo(a)pyrene	148-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
11164613-5	2001	Moreover, P-gp- and MRP1-overexpressing cells were shown to display similar accumulation and efflux of BP than those found in P-gp- and MRP1-negative control cells.	Benzo(a)pyrene	103-105	phosphoglycolate phosphatase	Rattus norvegicus	10-14
11164613-5	2001	Moreover, P-gp- and MRP1-overexpressing cells were shown to display similar accumulation and efflux of BP than those found in P-gp- and MRP1-negative control cells.	Benzo(a)pyrene	103-105	ATP binding cassette subfamily C member 1	Rattus norvegicus	20-24
11159756-0	2001	Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.	Benzo(a)pyrene	74-88	aryl-hydrocarbon receptor	Mus musculus	0-25
11171528-7	2001	In contrast, administration of BaP up-regulated only Cyp1a1 and Cyp1a2 genes and produced no significant increases in any of the stress response genes or any of the DNA repair genes present on the array.	Benzo(a)pyrene	31-34	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	53-59
11499694-8	2001	benzo-[a]-pyrene (BaP), PCB (polychlorinated biphenyl) congeners) environmental chemicals indicated that hematopoietic or stromal bone marrow cells were targets for most of the chemicals.	Benzo(a)pyrene	0-16	prohibitin 2	Mus musculus	18-21
11171528-7	2001	In contrast, administration of BaP up-regulated only Cyp1a1 and Cyp1a2 genes and produced no significant increases in any of the stress response genes or any of the DNA repair genes present on the array.	Benzo(a)pyrene	31-34	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	64-70
11211741-7	2001	Salt-induced hypertension experiment using alpha 2B-KO and alpha 2C-KO revealed that alpha 2B AR subtype is necessary to raise BP in response to dietary salt loading.	Benzo(a)pyrene	127-129	adrenergic receptor, alpha 2b	Mus musculus	85-96
11263662-5	2001	Subsequently, we over-expressed GDF-5 in the developing chick embryo using a replication competent retrovirus, RCAS(BP).	Benzo(a)pyrene	116-118	growth differentiation factor 5	Gallus gallus	32-37
11588892-1	2001	Monoclonal antibody (MAb) 1-7-1 against 3-methylcholanthrene (MC)-induced forms of cytochrome P-450 (CYP) was used to characterize benzo[a]pyrene (B[a]P) metabolism in rat liver and extrahepatic tissues and its modulation by phenolic antioxidants, propyl and octyl gallates.	Benzo(a)pyrene	131-145	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-99
11141357-0	2001	Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway.	Benzo(a)pyrene	52-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	75-81
11141357-0	2001	Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway.	Benzo(a)pyrene	52-66	aryl hydrocarbon receptor	Homo sapiens	101-126
11141357-6	2001	Our previous report showed that cytochrome P450 1A1 (CYP1A1) is responsible for the metabolic activation of BaP and the formation of B[a]P adduct in HepG2 cells.	Benzo(a)pyrene	108-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	32-51
11141357-6	2001	Our previous report showed that cytochrome P450 1A1 (CYP1A1) is responsible for the metabolic activation of BaP and the formation of B[a]P adduct in HepG2 cells.	Benzo(a)pyrene	108-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
11141357-7	2001	Western blot and Northern blot analyses were used to evaluate whether BaP-induced CYP1A1 protein and mRNA levels increased following the addition of BghiP.	Benzo(a)pyrene	70-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
11141357-8	2001	Our data showed that BghiP enhanced BaP-induced CYP1A1 protein and its mRNA levels.	Benzo(a)pyrene	36-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
11141357-9	2001	To understand whether BghiP enhances BaP-induced CYP1A1 gene expression through the aryl hydrocarbon receptor (AhR) signaling pathway, a gel retardation assay was performed to elucidate the synergistic mechanism of BghiP in BaP-induced CYP1A1 gene expression.	Benzo(a)pyrene	37-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-55
11141357-9	2001	To understand whether BghiP enhances BaP-induced CYP1A1 gene expression through the aryl hydrocarbon receptor (AhR) signaling pathway, a gel retardation assay was performed to elucidate the synergistic mechanism of BghiP in BaP-induced CYP1A1 gene expression.	Benzo(a)pyrene	37-40	aryl hydrocarbon receptor	Homo sapiens	84-109
11141357-12	2001	Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis.	Benzo(a)pyrene	46-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
11141357-12	2001	Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis.	Benzo(a)pyrene	46-49	aryl hydrocarbon receptor	Homo sapiens	82-85
11141357-12	2001	Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis.	Benzo(a)pyrene	46-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
11141357-12	2001	Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis.	Benzo(a)pyrene	206-209	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
11141357-12	2001	Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis.	Benzo(a)pyrene	206-209	aryl hydrocarbon receptor	Homo sapiens	82-85
11141357-12	2001	Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis.	Benzo(a)pyrene	206-209	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
12001579-16	2001	The hypothesis about the inverse relation of K(+)-intake to BP, especially to DBP is confirmed by our data.	Benzo(a)pyrene	60-62	D-box binding PAR bZIP transcription factor	Homo sapiens	78-81
11162432-5	2000	In vitro and whole-cell metabolic activity studies showed that the periplasmically-located CYP1A1 competently catalysed NADPH-dependent benzo[a]pyrene 3-hydroxylation and 7-ethoxyresorufin O-deethylation.	Benzo(a)pyrene	136-150	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	91-97
11201666-0	2000	Cytochrome P450-dependent binding of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) in murine heart, lung, and liver endothelial cells.	Benzo(a)pyrene	79-93	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-15
11154737-8	2000	Flavones, including quercetin and benzo(a)pyrene, are known inhibitors of NQO2.	Benzo(a)pyrene	34-48	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	74-78
11195457-7	2000	We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP).	Benzo(a)pyrene	262-276	transformation related protein 53, pseudogene	Mus musculus	28-31
11195457-7	2000	We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP).	Benzo(a)pyrene	278-280	transformation related protein 53, pseudogene	Mus musculus	28-31
11271841-1	2000	A simple, rapid and inexpensive method has been developed for the determination of benzo[a]pyrene (B(a)P, a known carcinogen) in foods with a high fat content.	Benzo(a)pyrene	83-97	prohibitin 2	Homo sapiens	99-104
11008122-0	2000	Profiles of antioxidant/electrophile response element (ARE/EpRE) nuclear protein binding and c-Ha-ras transactivation in vascular smooth muscle cells treated with oxidative metabolites of benzo[a]pyrene.	Benzo(a)pyrene	188-202	transcription factor like 5	Homo sapiens	93-97
11008122-1	2000	Activation of nuclear protein binding to the antioxidant/electrophile response element (ARE/EpRE) by benzo[a]pyrene (BaP) in vascular smooth muscle cells (vSMCs) is associated with transcriptional deregulation of c-Ha-ras.	Benzo(a)pyrene	101-115	transcription factor like 5	Homo sapiens	213-217
11008122-1	2000	Activation of nuclear protein binding to the antioxidant/electrophile response element (ARE/EpRE) by benzo[a]pyrene (BaP) in vascular smooth muscle cells (vSMCs) is associated with transcriptional deregulation of c-Ha-ras.	Benzo(a)pyrene	101-115	prohibitin 2	Homo sapiens	117-120
11196456-3	2000	When the patients were classified into two groups according to whether their preoperative BP was more (HBP group) or less (NBP group) than 140/90 mmHg, the BP level was found to be continuously higher in the HBP group than in the NBP group during the year after surgery.	Benzo(a)pyrene	90-92	heme binding protein 1	Homo sapiens	208-211
11065345-3	2000	Inactivation of either the epithelial Na(+) channel (ENaC) or the Na(+)-Cl(-) cotransporter decreases BP to the same extent in mice fed a low-salt diet, despite a more pronounced perturbation of fluid homeostasis in ENaC-deficient mice.	Benzo(a)pyrene	102-104	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	27-51
11053481-8	2000	Female rats transgenic for human renin that were mated with male rats transgenic for human angiotensinogen in contrast exhibited a decrease in BP.	Benzo(a)pyrene	143-145	renin	Homo sapiens	33-38
11053481-8	2000	Female rats transgenic for human renin that were mated with male rats transgenic for human angiotensinogen in contrast exhibited a decrease in BP.	Benzo(a)pyrene	143-145	angiotensinogen	Homo sapiens	91-106
11065345-3	2000	Inactivation of either the epithelial Na(+) channel (ENaC) or the Na(+)-Cl(-) cotransporter decreases BP to the same extent in mice fed a low-salt diet, despite a more pronounced perturbation of fluid homeostasis in ENaC-deficient mice.	Benzo(a)pyrene	102-104	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	53-57
11065345-4	2000	In contrast, inactivation of Na(+)/H(+) exchanger 3 (NHE3) or the Na(+)-K(+)-2Cl(-) contransporter reduces BP with a normal-salt diet and renders mice unable to survive with a low-salt diet.	Benzo(a)pyrene	107-109	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	29-51
11065345-4	2000	In contrast, inactivation of Na(+)/H(+) exchanger 3 (NHE3) or the Na(+)-K(+)-2Cl(-) contransporter reduces BP with a normal-salt diet and renders mice unable to survive with a low-salt diet.	Benzo(a)pyrene	107-109	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	53-57
11065345-7	2000	The overall effect of NHE3 inactivation on BP may also involve absorptive defects in the intestine and colon, where the exchanger normally reabsorbs significant amounts of Na(+) and water.	Benzo(a)pyrene	43-45	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	22-26
11041560-5	2000	TNF was undetectable in the plasma and peritoneal lavage fluid of animals co-injected with LPS and TNF bp, implying neutralization of peripheral bioactive TNF.	Benzo(a)pyrene	103-105	tumor necrosis factor-like	Rattus norvegicus	0-3
11119253-1	2000	Exposure of Wistar rats to the immunotoxic compounds hexachlorobenzene (HCB), bis(tri-n-butyltin)oxide, and benzo(a)pyrene was previously found to affect mRNA expression of interleukin (IL)-2, IL-2R alpha-chain, and interferon (IFN)-gamma, the prototypic Th1 cytokine.	Benzo(a)pyrene	108-122	interleukin 2	Rattus norvegicus	173-191
11119253-1	2000	Exposure of Wistar rats to the immunotoxic compounds hexachlorobenzene (HCB), bis(tri-n-butyltin)oxide, and benzo(a)pyrene was previously found to affect mRNA expression of interleukin (IL)-2, IL-2R alpha-chain, and interferon (IFN)-gamma, the prototypic Th1 cytokine.	Benzo(a)pyrene	108-122	interleukin 2 receptor subunit alpha	Rattus norvegicus	193-204
11119253-1	2000	Exposure of Wistar rats to the immunotoxic compounds hexachlorobenzene (HCB), bis(tri-n-butyltin)oxide, and benzo(a)pyrene was previously found to affect mRNA expression of interleukin (IL)-2, IL-2R alpha-chain, and interferon (IFN)-gamma, the prototypic Th1 cytokine.	Benzo(a)pyrene	108-122	interferon gamma	Rattus norvegicus	216-238
11059760-6	2000	On oral treatment with B[a]P, the tumor incidence increased in both wild-type and CSB-deficient animals.	Benzo(a)pyrene	23-28	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	82-85
11041560-5	2000	TNF was undetectable in the plasma and peritoneal lavage fluid of animals co-injected with LPS and TNF bp, implying neutralization of peripheral bioactive TNF.	Benzo(a)pyrene	103-105	tumor necrosis factor-like	Rattus norvegicus	99-102
11041560-5	2000	TNF was undetectable in the plasma and peritoneal lavage fluid of animals co-injected with LPS and TNF bp, implying neutralization of peripheral bioactive TNF.	Benzo(a)pyrene	103-105	tumor necrosis factor-like	Rattus norvegicus	99-102
10818089-3	2000	Overexpression of C/EBP-beta or C/EBP-alpha repressed, whereas AhR enhanced, 1.6CAT reporter activity in cells treated with benzo(a)pyrene (BaP).	Benzo(a)pyrene	124-138	CCAAT/enhancer binding protein beta	Rattus norvegicus	18-28
10818089-3	2000	Overexpression of C/EBP-beta or C/EBP-alpha repressed, whereas AhR enhanced, 1.6CAT reporter activity in cells treated with benzo(a)pyrene (BaP).	Benzo(a)pyrene	124-138	aryl hydrocarbon receptor	Rattus norvegicus	63-66
10818089-3	2000	Overexpression of C/EBP-beta or C/EBP-alpha repressed, whereas AhR enhanced, 1.6CAT reporter activity in cells treated with benzo(a)pyrene (BaP).	Benzo(a)pyrene	140-143	CCAAT/enhancer binding protein beta	Rattus norvegicus	18-28
10818089-3	2000	Overexpression of C/EBP-beta or C/EBP-alpha repressed, whereas AhR enhanced, 1.6CAT reporter activity in cells treated with benzo(a)pyrene (BaP).	Benzo(a)pyrene	140-143	aryl hydrocarbon receptor	Rattus norvegicus	63-66
10966494-7	2000	Furthermore, increases in the urinary albumin excretion and BP were significantly ameliorated in BNP-Tg.	Benzo(a)pyrene	60-62	natriuretic peptide type B	Mus musculus	97-100
11191113-0	2000	Disruption of cell cycle kinetics by benzo[a]pyrene: inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2.	Benzo(a)pyrene	37-51	BRCA1 DNA repair associated	Homo sapiens	84-90
11191113-0	2000	Disruption of cell cycle kinetics by benzo[a]pyrene: inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2.	Benzo(a)pyrene	37-51	tumor protein p53	Homo sapiens	95-98
10856296-1	2000	During previous studies, we found that mdm2 mRNA levels were elevated in benzo[a]pyrene (BaP, a polycyclic aryl hydrocarbon)-treated cells under conditions of DNA damage-induced cell cycle arrest (Vaziri, C., and Faller, D. V. (1997) J. Biol.	Benzo(a)pyrene	73-87	transformed mouse 3T3 cell double minute 2	Mus musculus	39-43
10856296-1	2000	During previous studies, we found that mdm2 mRNA levels were elevated in benzo[a]pyrene (BaP, a polycyclic aryl hydrocarbon)-treated cells under conditions of DNA damage-induced cell cycle arrest (Vaziri, C., and Faller, D. V. (1997) J. Biol.	Benzo(a)pyrene	73-87	prohibitin 2	Mus musculus	89-92
10936123-4	2000	DESIGN: A model of induced PP in a trained healthy subject without respiratory disease was constructed with a fixed inspiratory resistance with measurement of inspiratory air pressure and beat-to-beat BP noninvasively.	Benzo(a)pyrene	201-203	tachykinin precursor 1	Homo sapiens	27-29
10915744-3	2000	Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1.	Benzo(a)pyrene	194-196	nuclear factor kappa B subunit 1	Homo sapiens	60-66
10915744-3	2000	Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1.	Benzo(a)pyrene	194-196	nuclear factor kappa B subunit 1	Homo sapiens	68-77
10915744-3	2000	Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1.	Benzo(a)pyrene	194-196	nuclear factor kappa B subunit 1	Homo sapiens	301-310
10915744-5	2000	Four- and 10-fold activation of stress protein was detected by a consensus heat shock factor (HSF) sequence binding probe, with AFB and BP treatments, respectively.	Benzo(a)pyrene	136-138	interleukin 6	Homo sapiens	75-92
10915744-5	2000	Four- and 10-fold activation of stress protein was detected by a consensus heat shock factor (HSF) sequence binding probe, with AFB and BP treatments, respectively.	Benzo(a)pyrene	136-138	interleukin 6	Homo sapiens	94-97
10936229-4	2000	SOD and CAT activities were significantly increased in erythrocytes shortly after BaP exposure, and they were slightly decreased in sera, indicating an inverse correlation between lipid peroxidation and antioxidant enzyme activity.	Benzo(a)pyrene	82-85	catalase	Rattus norvegicus	8-11
11460755-2	2000	Experiments are described here that investigated whether BaP exposure inhibits the induction of metallothionein (MT), a major detoxifying protein for Cd, or if reactive BaP metabolites compete with Cd for binding sites on MT.	Benzo(a)pyrene	57-60	metallothionein-2	Fundulus heteroclitus	96-111
11460755-2	2000	Experiments are described here that investigated whether BaP exposure inhibits the induction of metallothionein (MT), a major detoxifying protein for Cd, or if reactive BaP metabolites compete with Cd for binding sites on MT.	Benzo(a)pyrene	57-60	metallothionein-2	Fundulus heteroclitus	113-115
11460755-5	2000	Simultaneous BaP exposure significantly delayed the induction of MT, for both low and high Cd doses, and BaP temporarily lowered the induced MT concentration when dosed 4 days after induction by Cd.	Benzo(a)pyrene	13-16	metallothionein-2	Fundulus heteroclitus	65-67
11460755-5	2000	Simultaneous BaP exposure significantly delayed the induction of MT, for both low and high Cd doses, and BaP temporarily lowered the induced MT concentration when dosed 4 days after induction by Cd.	Benzo(a)pyrene	105-108	metallothionein-2	Fundulus heteroclitus	141-143
11460755-9	2000	These results suggest that increased toxicity of Cd in combination with BaP exposure is likely to be caused by inhibited MT synthesis, rather than by interference of BaP metabolites with Cd binding on MT.	Benzo(a)pyrene	72-75	metallothionein-2	Fundulus heteroclitus	121-123
10860937-0	2000	Activation of c-Ha-ras by benzo(a)pyrene in vascular smooth muscle cells involves redox stress and aryl hydrocarbon receptor.	Benzo(a)pyrene	26-40	POC1 centriolar protein A	Mus musculus	14-18
10860937-0	2000	Activation of c-Ha-ras by benzo(a)pyrene in vascular smooth muscle cells involves redox stress and aryl hydrocarbon receptor.	Benzo(a)pyrene	26-40	aryl-hydrocarbon receptor	Mus musculus	99-124
10860937-4	2000	To test this hypothesis, we evaluated mitogen-activated c-Ha-ras expression in vSMCs treated with BaP or its metabolic intermediates alone, and in combination with agents that modulate cellular redox status.	Benzo(a)pyrene	98-101	Harvey rat sarcoma virus oncogene	Mus musculus	56-64
10860937-5	2000	BaP (0.3 and 3 microM), BaP-3, 6-quinone (0.3 microM), or hydrogen peroxide (50 microM) enhanced serum-activated c-Ha-ras.	Benzo(a)pyrene	0-3	POC1 centriolar protein A	Mus musculus	113-117
10860937-6	2000	Ellipticine (0.01 nM), a known inhibitor of cytochrome P450 metabolism and aryl hydrocarbon receptor (AhR) antagonist, inhibited c-Ha-ras induction by BaP (3 microM).	Benzo(a)pyrene	151-154	aryl-hydrocarbon receptor	Mus musculus	75-100
10860937-6	2000	Ellipticine (0.01 nM), a known inhibitor of cytochrome P450 metabolism and aryl hydrocarbon receptor (AhR) antagonist, inhibited c-Ha-ras induction by BaP (3 microM).	Benzo(a)pyrene	151-154	aryl-hydrocarbon receptor	Mus musculus	102-105
10860937-6	2000	Ellipticine (0.01 nM), a known inhibitor of cytochrome P450 metabolism and aryl hydrocarbon receptor (AhR) antagonist, inhibited c-Ha-ras induction by BaP (3 microM).	Benzo(a)pyrene	151-154	Harvey rat sarcoma virus oncogene	Mus musculus	129-137
10860937-8	2000	Combined BaP/DL-buthionine-(S, R)-sulfoximine challenge was cytotoxic to the cells and inhibited c-Ha-ras expression, whereas up-regulation of antioxidant capacity by N-acetylcysteine (0.5 mM) precluded BaP-induced ras expression.	Benzo(a)pyrene	9-12	Harvey rat sarcoma virus oncogene	Mus musculus	97-105
10860937-11	2000	These results suggest that c-Ha-ras activation in vSMCs by BaP involves a redox-sensitive mechanism that is coupled to AhR receptor-dependent functions.	Benzo(a)pyrene	59-62	POC1 centriolar protein A	Mus musculus	27-31
10860937-11	2000	These results suggest that c-Ha-ras activation in vSMCs by BaP involves a redox-sensitive mechanism that is coupled to AhR receptor-dependent functions.	Benzo(a)pyrene	59-62	aryl-hydrocarbon receptor	Mus musculus	119-122
10873718-4	2000	Twice weekly, for 38 weeks, topical application of NO-NTA at the concentration of 250 nmol to mice previously initiated with benzo(a)pyrene (BaP) caused 90% tumor incidence.	Benzo(a)pyrene	125-139	prohibitin 2	Mus musculus	141-144
10863157-11	2000	This smoking-associated shift of the HPRT mutational spectrum, although not statistically significant, is consistent with the in vitro mutagenicity of benzo(a)pyrene (BaP), a prominent carcinogen of tobacco smoke, and with known differences in the TP53 mutational spectrum in lung tumors of smokers and nonsmokers.	Benzo(a)pyrene	151-165	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	37-41
10863157-11	2000	This smoking-associated shift of the HPRT mutational spectrum, although not statistically significant, is consistent with the in vitro mutagenicity of benzo(a)pyrene (BaP), a prominent carcinogen of tobacco smoke, and with known differences in the TP53 mutational spectrum in lung tumors of smokers and nonsmokers.	Benzo(a)pyrene	167-170	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	37-41
10837373-3	2000	In the present study, the induction of p53 target gene expression after the treatment with either benzo(a)pyrene (B[a]P) or 1-nitropyrene (1-NP) was investigated.	Benzo(a)pyrene	98-112	tumor protein p53	Homo sapiens	39-42
10837020-0	2000	Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.	Benzo(a)pyrene	87-101	xeroderma pigmentosum, complementation group A	Mus musculus	54-57
10880142-2	2000	The focus of this article is a molecular evaluation of the neurotoxicological effects that result subsequent to the transplacental exposure of fetal rats to desorbed benzo(a)pyrene (BaP) following maternal inhalation.	Benzo(a)pyrene	166-180	prohibitin 2	Rattus norvegicus	182-185
10828263-0	2000	Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor-alpha reporter gene assay.	Benzo(a)pyrene	12-26	estrogen receptor 1	Homo sapiens	66-89
11778517-9	2000	CONCLUSIONS: Endothelial dysfunction associated with NO reduction might be present and VIP might be involved in regulating BP changes in patients with OSAS.	Benzo(a)pyrene	123-125	vasoactive intestinal peptide	Homo sapiens	87-90
10783306-6	2000	In non-tumorigenic MCF-10F cells, in vitro malignant transformation upon treatment with either DMBA or benzo[a]pyrene (B[a]P) resulted in a 4- to 12-fold increase in activity of classical NF-kappaB (p65/p50).	Benzo(a)pyrene	103-117	nuclear factor kappa B subunit 1	Homo sapiens	188-197
10783306-6	2000	In non-tumorigenic MCF-10F cells, in vitro malignant transformation upon treatment with either DMBA or benzo[a]pyrene (B[a]P) resulted in a 4- to 12-fold increase in activity of classical NF-kappaB (p65/p50).	Benzo(a)pyrene	103-117	RELA proto-oncogene, NF-kB subunit	Homo sapiens	199-202
10783306-6	2000	In non-tumorigenic MCF-10F cells, in vitro malignant transformation upon treatment with either DMBA or benzo[a]pyrene (B[a]P) resulted in a 4- to 12-fold increase in activity of classical NF-kappaB (p65/p50).	Benzo(a)pyrene	103-117	nuclear factor kappa B subunit 1	Homo sapiens	203-206
10877033-4	2000	RESULTS: During the production of fireproof stones, the German technical exposure limit (TRK) for benzo(a)pyrene of 2 microg/m3 was exceeded in two cases.	Benzo(a)pyrene	98-112	neurotrophic receptor tyrosine kinase 1	Homo sapiens	89-92
10764626-1	2000	The P-glycoprotein (P-gp)-negative epidermoid pharyngeal carcinoma cells KB-3-1 were grown in 0.25 mM benzo[a]pyrene (BaP) for 3 months and increased resistance to doxorubicin, but not to vinblastine, colchicine, or cisplatin, was found.	Benzo(a)pyrene	102-116	ATP binding cassette subfamily B member 1	Homo sapiens	4-18
10764626-3	2000	Intracellular accumulation of BaP or calcein, a substrate for P-gp and multidrug resistance protein (MRP), was not altered by inhibitors of the P-gp and MRP.	Benzo(a)pyrene	30-33	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
10764626-6	2000	BaP-treated KB-3-1 cells remained P-gp negative while the level of MRP was not altered.	Benzo(a)pyrene	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	34-38
10764626-12	2000	These results also propose an alternative mechanism of cancer drug resistance emergence, namely, induction of LRP activity following treatment with BaP, an environmental toxicant and a carcinogen.	Benzo(a)pyrene	148-151	major vault protein	Homo sapiens	110-113
10753208-1	2000	The mutation spectrum of the lacI gene from the liver of C57Bl6 Big Blue transgenic mice treated with benzo[a]pyrene (B[a]P) has been compared with the spectrum of spontaneous mutations observed in the liver of untreated Big Blue mice.	Benzo(a)pyrene	102-116	tissue factor pathway inhibitor	Mus musculus	29-33
10822009-5	2000	AhR agonists including TCDD, benzo[a]pyrene (BaP) and 6-methyl-1,3,8-trichlorodibenzofuran, inhibited 32-47% of the E2-induced responses.	Benzo(a)pyrene	29-43	aryl hydrocarbon receptor	Homo sapiens	0-3
10822009-5	2000	AhR agonists including TCDD, benzo[a]pyrene (BaP) and 6-methyl-1,3,8-trichlorodibenzofuran, inhibited 32-47% of the E2-induced responses.	Benzo(a)pyrene	45-48	aryl hydrocarbon receptor	Homo sapiens	0-3
10817400-11	2000	However, nitrate/nitrite is positively correlated to BP only in subjects with normoalbuminuria, and ET-1 is positively correlated to BP only in subjects with elevated UAE.	Benzo(a)pyrene	133-135	endothelin 1	Homo sapiens	100-104
10656492-5	1999	The abnormal expression of Ha-ras in the latter cells may enhance in this system the effects of the BP apoptosis path reported for BP-transformed Hepa 1c1c7 hepatoma cells.	Benzo(a)pyrene	100-102	Harvey rat sarcoma virus oncogene	Mus musculus	27-33
10675494-14	2000	Bax was downregulated in HOK-16B, HOK-16B-BaP and HOK-16B-BaP-T1.	Benzo(a)pyrene	42-45	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
10675494-14	2000	Bax was downregulated in HOK-16B, HOK-16B-BaP and HOK-16B-BaP-T1.	Benzo(a)pyrene	58-61	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
10708967-0	2000	Mutagenicity of benzo[a]pyrene-deoxyadenosine adducts in a sequence context derived from the p53 gene.	Benzo(a)pyrene	16-30	tumor protein p53	Homo sapiens	93-96
10708967-2	2000	Recent research has shown that tobacco-associated cancer in the human lung is related to mutation of the p53 gene mediated by the carcinogen benzo[a]pyrene (BaP), and the mutations are targeted to DNA "hot spots" at specific codons.	Benzo(a)pyrene	141-155	tumor protein p53	Homo sapiens	105-108
10708967-2	2000	Recent research has shown that tobacco-associated cancer in the human lung is related to mutation of the p53 gene mediated by the carcinogen benzo[a]pyrene (BaP), and the mutations are targeted to DNA "hot spots" at specific codons.	Benzo(a)pyrene	157-160	tumor protein p53	Homo sapiens	105-108
10751607-5	2000	The frequent G:C-->T:A transversions are consistent with reports of the mutational spectra produced in the p53 gene in tumors generated in rats and mice exposed to BP.	Benzo(a)pyrene	167-169	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	110-113
10676648-1	2000	Myeloperoxidase (MPO), an enzyme that is highly expressed in neutrophil leukocytes, transforms precarcinogens such as benzo(a)pyrene and aromatic amines to highly reactive intermediates.	Benzo(a)pyrene	118-132	myeloperoxidase	Homo sapiens	0-15
10676648-1	2000	Myeloperoxidase (MPO), an enzyme that is highly expressed in neutrophil leukocytes, transforms precarcinogens such as benzo(a)pyrene and aromatic amines to highly reactive intermediates.	Benzo(a)pyrene	118-132	myeloperoxidase	Homo sapiens	17-20
10739169-1	2000	Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and the hydroxylation of 17beta-estradiol at the C-4 position.	Benzo(a)pyrene	110-124	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19
10739169-1	2000	Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and the hydroxylation of 17beta-estradiol at the C-4 position.	Benzo(a)pyrene	110-124	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27
10739169-1	2000	Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and the hydroxylation of 17beta-estradiol at the C-4 position.	Benzo(a)pyrene	110-124	complement C4A (Rodgers blood group)	Homo sapiens	174-177
10639156-0	2000	Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	59-84
10709956-4	2000	The neuropeptide neurotensin was found to modulate baroreceptor control of BP and discharge of central barosensitive neurons, both through modulation of baroreceptor afferent input and possibly through release of neurotensin by baroreceptor afferent fibers in the NTS.	Benzo(a)pyrene	75-77	neurotensin	Homo sapiens	17-28
10678579-7	2000	COX-2 is inducible by oncogenes ras and scr, interleukin-1, hypoxia, benzo[a]pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha.	Benzo(a)pyrene	69-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10605936-5	2000	In contrast to dioxin, AHR ligands that are readily metabolized to ROMs (e.g. benzo[a]pyrene, beta-naphthoflavone) activate genes via both AHREs and the EPRE.	Benzo(a)pyrene	78-92	aryl hydrocarbon receptor	Homo sapiens	23-26
11201055-0	2000	Inhibition of platelet function by GSTM1-null human peripheral lymphocytes exposed to benzo(a)pyrene-induced challenge.	Benzo(a)pyrene	86-100	glutathione S-transferase mu 1	Homo sapiens	35-40
11201055-8	2000	However, our results indicate that lymphocytes of individuals with the GSTM1-null genotype have greater inhibitory activity on platelet function after exposure to BaP, but not CumOOH, although they are not more susceptible to in vitro oxidative stress.	Benzo(a)pyrene	163-166	glutathione S-transferase mu 1	Homo sapiens	71-76
10616838-4	2000	In Dahl-S rats, as shown by in-gel kinase assay, an increase in BP by a high-salt diet was followed by chronic activation of glomerular ERK and JNK, which continued until 10 wk after a high-salt diet.	Benzo(a)pyrene	64-66	mitogen-activated protein kinase 8	Rattus norvegicus	144-147
10711631-0	2000	Aryl hydrocarbon hydroxylase activity in F-344 rats subchronically exposed to benzo(a)pyrene and fluoranthene through diet.	Benzo(a)pyrene	78-92	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-28
10711631-1	2000	In order to investigate the relationship between aryl hydrocarbon hydroxylase (AHH) activity and exposure to benzo[a]pyrene [B(a)p] and fluoranthene (FLA), AHH activities in liver tissues of male and female F-344 rats were determined.	Benzo(a)pyrene	109-123	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	49-77
10711631-1	2000	In order to investigate the relationship between aryl hydrocarbon hydroxylase (AHH) activity and exposure to benzo[a]pyrene [B(a)p] and fluoranthene (FLA), AHH activities in liver tissues of male and female F-344 rats were determined.	Benzo(a)pyrene	109-123	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	79-82
10711631-1	2000	In order to investigate the relationship between aryl hydrocarbon hydroxylase (AHH) activity and exposure to benzo[a]pyrene [B(a)p] and fluoranthene (FLA), AHH activities in liver tissues of male and female F-344 rats were determined.	Benzo(a)pyrene	125-130	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	49-77
10711631-1	2000	In order to investigate the relationship between aryl hydrocarbon hydroxylase (AHH) activity and exposure to benzo[a]pyrene [B(a)p] and fluoranthene (FLA), AHH activities in liver tissues of male and female F-344 rats were determined.	Benzo(a)pyrene	125-130	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	79-82
10656492-5	1999	The abnormal expression of Ha-ras in the latter cells may enhance in this system the effects of the BP apoptosis path reported for BP-transformed Hepa 1c1c7 hepatoma cells.	Benzo(a)pyrene	131-133	Harvey rat sarcoma virus oncogene	Mus musculus	27-33
10575010-0	1999	Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activity.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	35-38
10575010-0	1999	Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activity.	Benzo(a)pyrene	0-14	nuclear factor kappa B subunit 1	Homo sapiens	80-86
10575010-2	1999	In the present study, the effect of a potent lung cancer carcinogen, benzo[a]pyrene (B[a]P) on p53 expression was investigated.	Benzo(a)pyrene	69-83	tumor protein p53	Homo sapiens	95-98
10597900-3	1999	This inhibition is correlated with the capacity of the isoflavones to prevent CYP1A1-mediated covalent binding of benzo[a]pyrene (BaP) metabolites to DNA.	Benzo(a)pyrene	114-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-84
10597900-3	1999	This inhibition is correlated with the capacity of the isoflavones to prevent CYP1A1-mediated covalent binding of benzo[a]pyrene (BaP) metabolites to DNA.	Benzo(a)pyrene	130-133	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-84
10597900-7	1999	Daidzein and genistein non-competitive with the CYP1A1 substrate BaP for microsomal BaP hydroxylation, with apparent Ki values of 325 microM and 140 microM, respectively.	Benzo(a)pyrene	65-68	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
10597900-7	1999	Daidzein and genistein non-competitive with the CYP1A1 substrate BaP for microsomal BaP hydroxylation, with apparent Ki values of 325 microM and 140 microM, respectively.	Benzo(a)pyrene	84-87	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
10598955-6	1999	CYP2B1 activity (benzyloxyresorufin O-dealkylase; BROD), which is responsible for metabolism of BaP to relatively nontoxic metabolites, was decreased in lung, as was, to a lesser extent, CYP1A1 (ethoxyresorufin O-dealkylase; EROD), which is responsible for metabolism of BaP to reactive/toxic metabolites.	Benzo(a)pyrene	96-99	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-6
10598955-6	1999	CYP2B1 activity (benzyloxyresorufin O-dealkylase; BROD), which is responsible for metabolism of BaP to relatively nontoxic metabolites, was decreased in lung, as was, to a lesser extent, CYP1A1 (ethoxyresorufin O-dealkylase; EROD), which is responsible for metabolism of BaP to reactive/toxic metabolites.	Benzo(a)pyrene	271-274	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-6
10447559-0	1999	Effects of solvent on DNA adduct formation in skin and lung of CD1 mice exposed cutaneously to benzo(a)pyrene.	Benzo(a)pyrene	95-109	CD1 antigen complex	Mus musculus	63-66
10548484-2	1999	Transient transfection of an AhRECAT reporter construct into vascular smooth muscle cells (vSMCs) or HepG2 cells showed that benzo(a)pyrene (BaP) (0.3-30 microM) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (0.	Benzo(a)pyrene	125-139	prohibitin 2	Homo sapiens	141-144
10548399-4	1999	Lipid peroxide accumulation and decreased glutathione (GSH) content and glutathione-S-transferase (GST) and DT diaphorase activities were observed in the liver of BP-treated tumour-bearing mice.	Benzo(a)pyrene	163-165	hematopoietic prostaglandin D synthase	Mus musculus	72-97
10548399-4	1999	Lipid peroxide accumulation and decreased glutathione (GSH) content and glutathione-S-transferase (GST) and DT diaphorase activities were observed in the liver of BP-treated tumour-bearing mice.	Benzo(a)pyrene	163-165	hematopoietic prostaglandin D synthase	Mus musculus	99-102
10548399-4	1999	Lipid peroxide accumulation and decreased glutathione (GSH) content and glutathione-S-transferase (GST) and DT diaphorase activities were observed in the liver of BP-treated tumour-bearing mice.	Benzo(a)pyrene	163-165	NAD(P)H dehydrogenase, quinone 1	Mus musculus	108-121
10493942-4	1999	BP1-E cells, derived from the immortalized MCF-10F cells transformed by the carcinogen benzo(a)pyrene (BP), express in vitro growth advantage, anchorage independence, enhanced chemoinvasiveness, loss of ductulogenic capabilities and tumorigenesis in a heterologous host.	Benzo(a)pyrene	87-101	BP1	Homo sapiens	0-3
10496959-4	1999	Resveratrol inhibited the B[a]P-induced expression of the CYP1A1 gene, as measured at the mRNA and transcriptional levels.	Benzo(a)pyrene	26-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
10496962-1	1999	Aryl hydrocarbon receptor (AhR) ligands such as dioxin and benzo[a]pyrene are environmental contaminants with many adverse health effects, including immunosuppression, carcinogenesis, and endothelial cell damage.	Benzo(a)pyrene	59-73	aryl hydrocarbon receptor	Homo sapiens	0-25
10496962-1	1999	Aryl hydrocarbon receptor (AhR) ligands such as dioxin and benzo[a]pyrene are environmental contaminants with many adverse health effects, including immunosuppression, carcinogenesis, and endothelial cell damage.	Benzo(a)pyrene	59-73	aryl hydrocarbon receptor	Homo sapiens	27-30
10506754-0	1999	Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide.	Benzo(a)pyrene	35-49	BRCA1 DNA repair associated	Homo sapiens	14-20
10506754-2	1999	Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells.	Benzo(a)pyrene	26-40	BRCA1 DNA repair associated	Homo sapiens	130-136
10506754-2	1999	Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells.	Benzo(a)pyrene	26-40	estrogen receptor 1	Homo sapiens	157-174
10506754-2	1999	Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells.	Benzo(a)pyrene	26-40	estrogen receptor 1	Homo sapiens	176-178
10506754-2	1999	Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells.	Benzo(a)pyrene	42-47	BRCA1 DNA repair associated	Homo sapiens	130-136
10506754-2	1999	Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells.	Benzo(a)pyrene	42-47	estrogen receptor 1	Homo sapiens	157-174
10506754-2	1999	Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells.	Benzo(a)pyrene	42-47	estrogen receptor 1	Homo sapiens	176-178
10527808-4	1999	Further, significantly different allele distributions were observed for ERDA1, with a larger proportion of BP patients (34.7%) carrying one or two expanded ERDA1 alleles (CAG/CTG repeats >40) than controls (19.2%) (P = 0.032).	Benzo(a)pyrene	107-109	expanded repeat domain, CAG/CTG 1	Homo sapiens	72-77
10527808-4	1999	Further, significantly different allele distributions were observed for ERDA1, with a larger proportion of BP patients (34.7%) carrying one or two expanded ERDA1 alleles (CAG/CTG repeats >40) than controls (19.2%) (P = 0.032).	Benzo(a)pyrene	107-109	expanded repeat domain, CAG/CTG 1	Homo sapiens	156-161
10469612-0	1999	Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.	Benzo(a)pyrene	101-115	Harvey rat sarcoma virus oncogene	Mus musculus	39-47
10469612-6	1999	The data indicate that c-Ha-ras mutations can be detected in normal-looking and hyperplastic epidermal cells as well as in tumor cells obtained from mice initiated with BP and promoted with TPA.	Benzo(a)pyrene	169-171	Harvey rat sarcoma virus oncogene	Mus musculus	23-31
10469612-13	1999	In summary, our data indicate that: (i) 79% of the BP/TPA skin tumors in CD-1 mice had c-Ha-ras mutations for the combined data for high dose and low dose tumors; (ii) the major mutations detected in BP/TPA skin tumors were G-->T transversions; (iii) the global mutation profile in the c-Ha-ras proto-oncogene in skin tumors obtained after initiation with a low dose of BP was different from that obtained after initiation with a high dose of BP.	Benzo(a)pyrene	51-53	POC1 centriolar protein A	Mus musculus	87-91
10469612-13	1999	In summary, our data indicate that: (i) 79% of the BP/TPA skin tumors in CD-1 mice had c-Ha-ras mutations for the combined data for high dose and low dose tumors; (ii) the major mutations detected in BP/TPA skin tumors were G-->T transversions; (iii) the global mutation profile in the c-Ha-ras proto-oncogene in skin tumors obtained after initiation with a low dose of BP was different from that obtained after initiation with a high dose of BP.	Benzo(a)pyrene	51-53	Harvey rat sarcoma virus oncogene	Mus musculus	87-95
10469621-0	1999	Thapsigargin has similar effect on p53 protein response to benzo[a]pyrene-DNA adducts as TPA in mouse skin.	Benzo(a)pyrene	59-73	transformation related protein 53, pseudogene	Mus musculus	35-38
10469621-1	1999	The level of p53 tumor suppressor protein increases in response to DNA damage caused by benzo[a]pyrene (B[a]P).	Benzo(a)pyrene	88-102	transformation related protein 53, pseudogene	Mus musculus	13-16
10469621-4	1999	We also studied the localization of p53 protein after treatments with BP and TPA or thapsigargin.	Benzo(a)pyrene	70-72	transformation related protein 53, pseudogene	Mus musculus	36-39
10442528-7	1999	In nonatopics, the expression of CD154 could be induced only after exposure to BP and subsequent lipopolysaccharide (LPS) stimulation.	Benzo(a)pyrene	79-81	CD40 ligand	Homo sapiens	33-38
10442528-9	1999	CD11a and HLA-DR expressions were upregulated, irrespective of atopic state, after BP and/or LPS stimulation.	Benzo(a)pyrene	83-85	integrin subunit alpha L	Homo sapiens	0-5
10442528-10	1999	The increased secretion of IL-5 and total IgE in BP-supplemented cell cultures indicated that an allergic response had occurred.	Benzo(a)pyrene	49-51	interleukin 5	Homo sapiens	27-31
10442528-10	1999	The increased secretion of IL-5 and total IgE in BP-supplemented cell cultures indicated that an allergic response had occurred.	Benzo(a)pyrene	49-51	immunoglobulin heavy constant epsilon	Homo sapiens	42-45
10409402-0	1999	Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	100-119
10409402-2	1999	Activation of benzo[a]pyrene to genotoxic products that cause induction of umu gene expression in Salmonella typhimurium NM2009 by P450 1A1 and P450 1B1 enzymes was found to be enhanced by inclusion of purified epoxide hydrolase (isolated from rat or human livers) with the reaction mixture.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	144-152
10409402-6	1999	A reconstituted system containing purified P450 1B1, rabbit liver NADPH-P450 reductase, and human liver epoxide hydrolase was found to catalyze benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene at a rate of 0.86 nmol min(-)(1) nmol of P450(-)(1); the activities were found to be largely dependent on the presence of sodium cholate in the system.	Benzo(a)pyrene	144-158	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	43-51
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	89-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-35
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	89-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	190-198
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	139-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-35
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	139-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	190-198
10335444-6	1999	Studies with stably expressed isoforms suggest that UGT1A9 is responsible for the formation of benzo(a)pyrene-3.6-diphenol diglucuronide, the major biliary metabolite of benzo(a)pyrene.	Benzo(a)pyrene	95-109	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	52-58
10230769-1	1999	The intracellular aryl hydrocarbon receptor (AhR) mediates signal transduction by environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene by functioning as a ligand-activated transcription factor.	Benzo(a)pyrene	162-176	aryl hydrocarbon receptor	Homo sapiens	18-43
10230769-1	1999	The intracellular aryl hydrocarbon receptor (AhR) mediates signal transduction by environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene by functioning as a ligand-activated transcription factor.	Benzo(a)pyrene	162-176	aryl hydrocarbon receptor	Homo sapiens	45-48
10230769-2	1999	We have investigated AhR signaling in sublines of the human breast cancer cell line MCF-7 selected for resistance to AdriamycinR (AdrR) and benzo[a]pyrene (BP(R)).	Benzo(a)pyrene	140-154	aryl hydrocarbon receptor	Homo sapiens	21-24
10230769-8	1999	BP(R) cells were found to be ER-positive, although chronic (BP(R) cells) and acute (24 hr) exposure to benzo[a]pyrene led to significantly lower ER protein levels in MCF-7 cells.	Benzo(a)pyrene	103-117	estrogen receptor 1	Homo sapiens	145-147
10357803-1	1999	Dibenzo[a,l]pyrene (DBP), an environmentally significant polycyclic aromatic hydrocarbon (PAH), is one of the most potent carcinogens with greater carcinogenicity in rodent mammary glands and skin than 7,12-dimethylbenz[a]anthracene or benzo[a]pyrene, respectively.	Benzo(a)pyrene	236-250	D-box binding PAR bZIP transcription factor	Rattus norvegicus	20-23
10385146-2	1999	Glutathione S-transferase M1 (GSTM1) detoxifies benzo(a)pyrene and other carcinogens in tobacco smoke.	Benzo(a)pyrene	48-62	glutathione S-transferase mu 1	Homo sapiens	0-28
10385146-2	1999	Glutathione S-transferase M1 (GSTM1) detoxifies benzo(a)pyrene and other carcinogens in tobacco smoke.	Benzo(a)pyrene	48-62	glutathione S-transferase mu 1	Homo sapiens	30-35
10381141-0	1999	Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1.	Benzo(a)pyrene	27-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	99-119
10381141-1	1999	Benzo(a)pyrene, a well-known procarcinogen, is believed to be activated by microsomal cytochrome P-450 1A1 (CYP 1A1).	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	86-106
10381141-1	1999	Benzo(a)pyrene, a well-known procarcinogen, is believed to be activated by microsomal cytochrome P-450 1A1 (CYP 1A1).	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	108-115
10344744-9	1999	Thus, hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to tumorigenesis induced by benzo[a]pyrene.	Benzo(a)pyrene	129-143	glutathione S-transferase pi 1	Homo sapiens	6-14
10374834-6	1999	The frequency of Ha- and Ki-ras mutations in liver tumors of mice treated with BaP, BaP trans-7,8-dihydrodiol, and 6-NC were higher than in the few liver tumors isolated from control mice or mice treated with the NBaPs or their metabolites.	Benzo(a)pyrene	79-82	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	25-31
10224324-7	1999	Benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene demonstrated mutagenicity in the CYP1A1 expressing strain with mutagenic activities, respectively, approximately 10-fold and 100-fold higher as compared with those obtained with the use of rat liver S9 fraction.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	83-89
10355543-4	1999	The IC50 for benzo(a)pyrene with human recombinant AChE was 1.5 microM.	Benzo(a)pyrene	13-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55
10355543-7	1999	Kinetic studies indicated that benzo(a)pyrene inhibited AChE in a noncompetitive manner, and the reduction in maximal velocity (Vmax) by benzo(a)pyrene and CPFO together was the sum of the inhibitory effect of the two inhibitors alone, further supporting an additive effect.	Benzo(a)pyrene	31-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
10355543-7	1999	Kinetic studies indicated that benzo(a)pyrene inhibited AChE in a noncompetitive manner, and the reduction in maximal velocity (Vmax) by benzo(a)pyrene and CPFO together was the sum of the inhibitory effect of the two inhibitors alone, further supporting an additive effect.	Benzo(a)pyrene	137-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
10217447-8	1999	[4] The early BP component (BP1) was always localized in the fronto-central midline (overlying the mesial wall motor areas SMA and CMA).	Benzo(a)pyrene	14-16	BP1	Homo sapiens	28-31
10359454-2	1999	However, the results of studies on tumorigenesis and DNA binding of benzo[a]pyrene (BP) and its bay-region diol epoxide, (+)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyren e [(+)-anti-BPDE] suggest that, in addition to anti-BPDE, other reactive metabolite(s) of BP may also be involved in BP-induced carcinogenesis.	Benzo(a)pyrene	84-86	dacapo	Drosophila melanogaster	49-50
10359454-2	1999	However, the results of studies on tumorigenesis and DNA binding of benzo[a]pyrene (BP) and its bay-region diol epoxide, (+)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyren e [(+)-anti-BPDE] suggest that, in addition to anti-BPDE, other reactive metabolite(s) of BP may also be involved in BP-induced carcinogenesis.	Benzo(a)pyrene	84-86	dacapo	Drosophila melanogaster	74-75
10359454-3	1999	Recent studies have demonstrated that 3-hydroxy-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a ]pyrene (anti-BPTE) is another highly reactive metabolite of BP.	Benzo(a)pyrene	125-127	dacapo	Drosophila melanogaster	16-17
10201880-2	1999	Although the acute effects of angiotensin II (AngII), the primary active component of the RAS, on arterial pressure are mediated primarily by peripheral vasoconstriction, its chronic BP effects are closely intertwined with volume homeostasis, particularly with intrarenal actions that influence pressure natriuresis.	Benzo(a)pyrene	183-185	angiotensinogen	Homo sapiens	30-44
10201880-2	1999	Although the acute effects of angiotensin II (AngII), the primary active component of the RAS, on arterial pressure are mediated primarily by peripheral vasoconstriction, its chronic BP effects are closely intertwined with volume homeostasis, particularly with intrarenal actions that influence pressure natriuresis.	Benzo(a)pyrene	183-185	angiotensinogen	Homo sapiens	46-51
10201883-4	1999	These new drugs are highly selective for the AT1 receptor subtype and induce dose-dependent inhibition of the BP response to exogenous AngII.	Benzo(a)pyrene	110-112	angiotensinogen	Homo sapiens	135-140
10037450-0	1999	Mono- and Diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.	Benzo(a)pyrene	39-53	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	101-128
10037450-0	1999	Mono- and Diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.	Benzo(a)pyrene	39-53	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	129-135
10037450-4	1999	It was found that UGT1A7 indeed catalyzed mono- and diglucuronide formation of both benzo[a]pyrene and chrysene 3,6-diphenols.	Benzo(a)pyrene	84-98	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	18-24
10095131-1	1999	We report the ability of beta-carotene (betaC) to affect the cell transforming activity of 3-methylcholanthrene (3-MCA), benzo(a)pyrene (B(a)P) and cigarette-smoke condensate (TAR) in an in vitro medium-term (approximately 8 weeks) experimental model utilizing BALB/c 3T3 cells.	Benzo(a)pyrene	121-135	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Mus musculus	25-46
10102040-3	1999	Here we show that pTpT treatment of human keratinocytes enhances their repair of DNA damaged by the chemical carcinogen benzo(a)pyrene (BP), as determined by increased expression of a transfected BP-damaged reporter plasmid containing the chloramphenicol acetyltransferase (CAT) gene.	Benzo(a)pyrene	120-134	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	18-22
10102040-3	1999	Here we show that pTpT treatment of human keratinocytes enhances their repair of DNA damaged by the chemical carcinogen benzo(a)pyrene (BP), as determined by increased expression of a transfected BP-damaged reporter plasmid containing the chloramphenicol acetyltransferase (CAT) gene.	Benzo(a)pyrene	136-138	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	18-22
10102040-3	1999	Here we show that pTpT treatment of human keratinocytes enhances their repair of DNA damaged by the chemical carcinogen benzo(a)pyrene (BP), as determined by increased expression of a transfected BP-damaged reporter plasmid containing the chloramphenicol acetyltransferase (CAT) gene.	Benzo(a)pyrene	196-198	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	18-22
10374834-6	1999	The frequency of Ha- and Ki-ras mutations in liver tumors of mice treated with BaP, BaP trans-7,8-dihydrodiol, and 6-NC were higher than in the few liver tumors isolated from control mice or mice treated with the NBaPs or their metabolites.	Benzo(a)pyrene	84-87	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	25-31
10224359-2	1999	We previously demonstrated that simultaneous inhalation of BP and cholera toxin, a potent mucosal adjuvant, induced a Th1-like immune response to the allergen in naive mice and modulated allergic immune responses in sensitized mice.	Benzo(a)pyrene	59-61	negative elongation factor complex member C/D, Th1l	Mus musculus	118-121
10067980-5	1999	RESULTS: The nucleotide sequence of the novel VEGF species isolated from human Muller cells had a short exon 6-encoded sequence without 18-bp nucleotides immediately upstream of the exon 7-encoded sequence in VEGF189.	Benzo(a)pyrene	139-141	vascular endothelial growth factor A	Homo sapiens	46-50
10378872-1	1999	Myelin basic protein (BP)-specific T lymphocyte cell lines were selected from the lymph nodes (LN) of BP-immunized, H-2d, CXJ-1 mice prior to the onset of clinical disease.	Benzo(a)pyrene	22-24	myelin basic protein	Mus musculus	0-20
10190573-6	1999	Based on different efficacies the concentration-response characteristics of CYP1A1 induction were analyzed in more detail for benzo[a]pyrene, benzo[k]fluoranthene, and acenaphthylene.	Benzo(a)pyrene	126-140	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	76-82
10190573-7	1999	Benzo[k]fluoranthene was markedly less effective than benzo[a]pyrene as inducer of EROD activity but even more effective than benzo[a]pyrene as inducer of CYP1A1 protein and mRNA.	Benzo(a)pyrene	126-140	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	155-161
10029669-1	1999	We have determined the mutational specificity of S9-activated benzo[a]pyrene (B[a]P) at the endogenous aprt locus in a hemizygous Chinese hamster ovary cell line.	Benzo(a)pyrene	62-76	adenine phosphoribosyltransferase	Cricetulus griseus	103-107
9920731-4	1999	The topical application of 50 microg/cm2 BaP to EpiDerm resulted in the accumulation of BaP-DNA adducts and c-fos and p53 proteins as evidenced by immunohistochemical localization.	Benzo(a)pyrene	41-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
9920731-4	1999	The topical application of 50 microg/cm2 BaP to EpiDerm resulted in the accumulation of BaP-DNA adducts and c-fos and p53 proteins as evidenced by immunohistochemical localization.	Benzo(a)pyrene	41-44	tumor protein p53	Homo sapiens	118-121
9858665-0	1999	Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro.	Benzo(a)pyrene	99-113	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-19
9858665-7	1999	The benzo(a)pyrene mutagenicity was detected using Salmonella typhimurium TA100 in the Ames test, and correlated positively with lymphocyte CYP1A1 content.	Benzo(a)pyrene	4-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	140-146
10746437-1	1999	When transfected to benzo[a]pyrene (BP)-transformed MCF-10F human breast epithelial cells (BP1 cell line) the c-Ha-ras oncogene has proven to enhance the neoplastic changes initiated by exposure to BP, giving rise to an aggressive tumorigenic cell line, BP1-Tras.	Benzo(a)pyrene	20-34	BP1	Homo sapiens	91-94
10746437-1	1999	When transfected to benzo[a]pyrene (BP)-transformed MCF-10F human breast epithelial cells (BP1 cell line) the c-Ha-ras oncogene has proven to enhance the neoplastic changes initiated by exposure to BP, giving rise to an aggressive tumorigenic cell line, BP1-Tras.	Benzo(a)pyrene	20-34	BP1	Homo sapiens	254-257
10746437-1	1999	When transfected to benzo[a]pyrene (BP)-transformed MCF-10F human breast epithelial cells (BP1 cell line) the c-Ha-ras oncogene has proven to enhance the neoplastic changes initiated by exposure to BP, giving rise to an aggressive tumorigenic cell line, BP1-Tras.	Benzo(a)pyrene	36-38	BP1	Homo sapiens	91-94
10746437-1	1999	When transfected to benzo[a]pyrene (BP)-transformed MCF-10F human breast epithelial cells (BP1 cell line) the c-Ha-ras oncogene has proven to enhance the neoplastic changes initiated by exposure to BP, giving rise to an aggressive tumorigenic cell line, BP1-Tras.	Benzo(a)pyrene	36-38	BP1	Homo sapiens	254-257
10331078-1	1999	Cytochrome P4501A1 is a substrate-inducible microsomal enzyme that oxygenates polycyclic aromatic hydrocarbons, such as the carcinogen benzo(a)pyrene, as the initial step in their metabolic processing to water-soluble derivatives.	Benzo(a)pyrene	135-149	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-18
23898793-0	1999	Short Communication: The effect of CYP1A1 induction on the formation of benzo a pyrene adducts in liver and lung DNA and plasma albumin in rats exposed to benzo a pyrene:adduct quantitation by immunoassay and an HPLC method.	Benzo(a)pyrene	72-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	35-41
23898793-0	1999	Short Communication: The effect of CYP1A1 induction on the formation of benzo a pyrene adducts in liver and lung DNA and plasma albumin in rats exposed to benzo a pyrene:adduct quantitation by immunoassay and an HPLC method.	Benzo(a)pyrene	155-169	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	35-41
9934854-1	1999	The potent mutagen/carcinogen 7R,8S-dihydroxy-9S, 10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-B[a]PDE], which is the activated form of benzo[a]pyrene (B[a]P), is able to induce different kinds of mutations (G-->T, G-->A, etc.).	Benzo(a)pyrene	79-93	aldehyde dehydrogenase 7 family member A1	Homo sapiens	108-111
10037326-5	1999	Benzo[a]pyrene (BaP) yielded similar mutation profiles as its ultimate mutagen BPDE, if 100-fold increased doses were applied.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
10503953-5	1999	Cotreatment with alpha-naphthoflavone, a CYP1A1 inhibitor, abolished DNA adduct formation by B[a]P in CL3 cells.	Benzo(a)pyrene	93-98	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	41-47
10503953-5	1999	Cotreatment with alpha-naphthoflavone, a CYP1A1 inhibitor, abolished DNA adduct formation by B[a]P in CL3 cells.	Benzo(a)pyrene	93-98	adhesion G protein-coupled receptor L3	Homo sapiens	102-105
10693172-0	1999	Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression.	Benzo(a)pyrene	19-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-108
9918813-4	1998	Aac11 apoptosis inhibitor, aldose reductase, GalNAc transferase, TCP-1 chaperonin gene, and mouse mitochondrial gene, were downregulated in vSMCs treated with BaP.	Benzo(a)pyrene	159-162	apoptosis inhibitor 5	Mus musculus	0-5
9918813-4	1998	Aac11 apoptosis inhibitor, aldose reductase, GalNAc transferase, TCP-1 chaperonin gene, and mouse mitochondrial gene, were downregulated in vSMCs treated with BaP.	Benzo(a)pyrene	159-162	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	27-43
9990312-5	1998	The mRNAs of UGT1A6 (glucuronizing various phenolic xenobiotics) and the mRNAs of UGT1A7 (glucuronizing the ultimate carcinogenic metabolite of benzo(a)pyrene) were expressed constitutively and were highly induced in the duodenum and proximal jejunum.	Benzo(a)pyrene	144-158	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	13-19
9990312-5	1998	The mRNAs of UGT1A6 (glucuronizing various phenolic xenobiotics) and the mRNAs of UGT1A7 (glucuronizing the ultimate carcinogenic metabolite of benzo(a)pyrene) were expressed constitutively and were highly induced in the duodenum and proximal jejunum.	Benzo(a)pyrene	144-158	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	82-88
9920462-1	1998	Benzo[a]pyrene (BaP) and other polycyclic aromatic hydrocarbons (PAHs) which are present in cigarette smoke, are common air and food genotoxic contaminants and possible human carcinogens.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
9815112-3	1998	In this study, we demonstrate that cultured macrophages (RAW 264.7 cells) exposed continously to a well-defined model of PM [benzo[a]pyrene adsorbed on carbon black (CB+BaP)] exhibit a time-dependent expression and release of the cytokine tumor necrosis factor-alpha (TNF-alpha).	Benzo(a)pyrene	125-139	tumor necrosis factor	Mus musculus	239-266
9815112-3	1998	In this study, we demonstrate that cultured macrophages (RAW 264.7 cells) exposed continously to a well-defined model of PM [benzo[a]pyrene adsorbed on carbon black (CB+BaP)] exhibit a time-dependent expression and release of the cytokine tumor necrosis factor-alpha (TNF-alpha).	Benzo(a)pyrene	125-139	tumor necrosis factor	Mus musculus	268-277
9855010-9	1998	There was also a significant correlation between serum p53 protein levels and the cumulated benzo[a]pyrene exposure dose.	Benzo(a)pyrene	92-106	tumor protein p53	Homo sapiens	55-58
9855012-5	1998	Here we determined to which extent heterologously expressed human GSTP1-1, a major GST isoform in lung, affects the mutagenicity of stereoisomeric bay-region DEs of benzo[a]pyrene in Chinese hamster V79 cells.	Benzo(a)pyrene	165-179	glutathione S-transferase pi 1	Homo sapiens	66-73
9855012-7	1998	GSTP1-1,reduced preferentially the mutagenicity (studied at the hprt locus) of (+)-anti and (+)-syn-DEs of benzo[a]pyrene (by 66 and 67%) as compared with the corresponding (-)-anti- and (-)-syn-enantiomers (by 15 and 13%).	Benzo(a)pyrene	107-121	glutathione S-transferase P 1	Cricetulus griseus	0-7
9855012-8	1998	These results are in line with previous studies on the enantioselectivity of purified GSTP1-1 towards the DE isomers of benzo[a]pyrene and benzo[c]phenanthrene showing that enantiomers with (R)-configuration at the benzylic oxiranyl carbon are better substrates than those with (S)-configuration.	Benzo(a)pyrene	120-134	glutathione S-transferase P 1	Cricetulus griseus	86-93
10048495-9	1998	More recent results were obtained in obese hypertensive patients in whom the intravenous bolus injection of ANP (0.6 mg/kg body weight) was performed before and after four days of very-low-calorie diet which induced a weight loss accompanied by a significant reduction of BP and an increase in the urinary excretion of cGMP.	Benzo(a)pyrene	272-274	natriuretic peptide A	Homo sapiens	108-111
10048495-10	1998	The infusion of ANP after low-calorie diet was followed by an increase of ANP levels similar to that observed before diet, but plasma cGMP, diuresis and natriuresis significantly increased only after caloric restriction and the effects of ANP infusion on BP were more pronounced.	Benzo(a)pyrene	255-257	natriuretic peptide A	Homo sapiens	16-19
10656108-8	1998	Furthermore, we determined that the D2.B6N-Asp1b mouse expresses both the D2 phenotype and genotype at the Ahr locus, i.e., zoxazolamine paralysis and T to C and G to A transition mutations in the Ahr cDNA at bp sites 3330 and 3336, respectively.	Benzo(a)pyrene	209-211	aryl-hydrocarbon receptor	Mus musculus	107-110
9801155-2	1998	Electrophoresis mobility shift assays demonstrated GATA-3 binds to the GATA consensus site from bp -256 to -250.	Benzo(a)pyrene	96-98	GATA binding protein 3	Homo sapiens	51-57
9801155-2	1998	Electrophoresis mobility shift assays demonstrated GATA-3 binds to the GATA consensus site from bp -256 to -250.	Benzo(a)pyrene	96-98	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	51-55
9806168-0	1998	Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-85
9806168-5	1998	The results of these studies indicate that cytochrome P450 1B1 carries out metabolism of B[a]P along the pathway to the postulated ultimate carcinogen, the diol epoxide 2, at rates much higher than P450 1A2 but less than P450 1A1.	Benzo(a)pyrene	89-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	43-62
9852999-1	1998	Benzo(a)pyrene (BaP) and related aromatic hydrocarbons are suspected carcinogens; however, the molecular basis underlying tumorigenesis remains unclear.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
9683293-3	1998	In vitro treatment of MCF-10F cells with benzo(a)pyrene resulted in a transformed subclone MCF-10F-BP1 (BP1).	Benzo(a)pyrene	41-55	BP1	Homo sapiens	91-102
9827359-0	1998	Immunophenotype, ras oncogenes and p53 onco-suppressor gene in benzo(a)pyrene induced malignant soft tissue tumours in Wistar rats.	Benzo(a)pyrene	63-77	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	35-38
9792191-6	1998	The CD25 (IL-2Ralpha chain) positive cells of BP-stimulated human lymphocytes assessed by indirect immunofluorescence were 53.97+/-7.12% (1 microg/ml) and 42.53+/-4.4% (10 microg/ml), significantly higher than the control (11.77+/-1.88%; P < 0.001).	Benzo(a)pyrene	46-48	interleukin 2 receptor subunit alpha	Homo sapiens	4-8
9792191-6	1998	The CD25 (IL-2Ralpha chain) positive cells of BP-stimulated human lymphocytes assessed by indirect immunofluorescence were 53.97+/-7.12% (1 microg/ml) and 42.53+/-4.4% (10 microg/ml), significantly higher than the control (11.77+/-1.88%; P < 0.001).	Benzo(a)pyrene	46-48	interleukin 2 receptor subunit alpha	Homo sapiens	10-20
9726695-11	1998	The somewhat more intense reduction in PWV with Vera/Tran is indicative of an increase in aortic elastic properties associated with the more potent decrease in BP.	Benzo(a)pyrene	160-162	tRNA-Ala (anticodon TGC) 7-1	Homo sapiens	53-57
9731718-1	1998	Because aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine CYP1A1 (AHH) activity in the determination of susceptibility to lung cancer.	Benzo(a)pyrene	97-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	8-36
9731718-1	1998	Because aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine CYP1A1 (AHH) activity in the determination of susceptibility to lung cancer.	Benzo(a)pyrene	97-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-41
9707513-6	1998	Immunoblot analysis demonstrated that both BaP and its 7,8-dihydrodiol metabolite affected a pathway involving Bcl-2 and Bax cytosolic proteins.	Benzo(a)pyrene	43-46	BCL2 apoptosis regulator	Homo sapiens	111-116
9707513-6	1998	Immunoblot analysis demonstrated that both BaP and its 7,8-dihydrodiol metabolite affected a pathway involving Bcl-2 and Bax cytosolic proteins.	Benzo(a)pyrene	43-46	BCL2 associated X, apoptosis regulator	Homo sapiens	121-124
9707513-7	1998	Daudi cells undergoing apoptosis at 36 h in response to 10 microM BaP, the parent compound, expressed moderately reduced amounts of Bcl-2 (78% of vehicle controls).	Benzo(a)pyrene	66-69	BCL2 apoptosis regulator	Homo sapiens	132-137
9707513-16	1998	Taken together, these data suggest that modulation of Bcl-2 family proteins, perhaps secondary to altered Ca2+ homeostasis, plays an important role in human B cell apoptosis induced by BaP.	Benzo(a)pyrene	185-188	BCL2 apoptosis regulator	Homo sapiens	54-59
20654422-1	1998	In the present study, the time- and concentration-dependent effects of the carcinogen benzo[a]pyrene (BaP) on c-fos, c-jun, c-myc and c-Ha-ras expression were evaluated in primary cultured rat hepatocytes.	Benzo(a)pyrene	86-100	prohibitin 2	Rattus norvegicus	102-105
20654422-1	1998	In the present study, the time- and concentration-dependent effects of the carcinogen benzo[a]pyrene (BaP) on c-fos, c-jun, c-myc and c-Ha-ras expression were evaluated in primary cultured rat hepatocytes.	Benzo(a)pyrene	86-100	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
9683293-3	1998	In vitro treatment of MCF-10F cells with benzo(a)pyrene resulted in a transformed subclone MCF-10F-BP1 (BP1).	Benzo(a)pyrene	41-55	BP1	Homo sapiens	99-102
9661901-10	1998	In addition, after chronic exposure to benzo(a)pyrene, Hprt mutants were readily detectable in XPA mice at an early onset of treatment but only at a later stage in normal mice.	Benzo(a)pyrene	39-53	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	55-59
9661901-10	1998	In addition, after chronic exposure to benzo(a)pyrene, Hprt mutants were readily detectable in XPA mice at an early onset of treatment but only at a later stage in normal mice.	Benzo(a)pyrene	39-53	xeroderma pigmentosum, complementation group A	Mus musculus	95-98
9683191-0	1998	Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line.	Benzo(a)pyrene	0-14	insulin	Homo sapiens	77-84
9683191-3	1998	In the present studies we found that BaP and TCDD activated insulin-like growth factor (IGF-I) signaling pathways under insulin-deficient conditions.	Benzo(a)pyrene	37-40	insulin	Homo sapiens	60-67
9683191-3	1998	In the present studies we found that BaP and TCDD activated insulin-like growth factor (IGF-I) signaling pathways under insulin-deficient conditions.	Benzo(a)pyrene	37-40	insulin like growth factor 1	Homo sapiens	88-93
9683191-5	1998	BaP (0.3 microM) and TCDD (30 nM) were found to restore a moderate insulin-like signal in MCF-10A cells grown in the absence of added insulin.	Benzo(a)pyrene	0-3	insulin	Homo sapiens	67-74
9683191-7	1998	Both TCDD and BaP appeared to mimic signaling through the IGF-I receptor (IGF-IR), as evidenced by increased tyrosine phosphophorylation of IGF-IRbeta, IRS-1 and Shc.	Benzo(a)pyrene	14-17	insulin like growth factor 1 receptor	Homo sapiens	58-72
9683191-7	1998	Both TCDD and BaP appeared to mimic signaling through the IGF-I receptor (IGF-IR), as evidenced by increased tyrosine phosphophorylation of IGF-IRbeta, IRS-1 and Shc.	Benzo(a)pyrene	14-17	insulin like growth factor 1 receptor	Homo sapiens	74-80
9683191-7	1998	Both TCDD and BaP appeared to mimic signaling through the IGF-I receptor (IGF-IR), as evidenced by increased tyrosine phosphophorylation of IGF-IRbeta, IRS-1 and Shc.	Benzo(a)pyrene	14-17	insulin receptor substrate 1	Homo sapiens	152-157
9683191-7	1998	Both TCDD and BaP appeared to mimic signaling through the IGF-I receptor (IGF-IR), as evidenced by increased tyrosine phosphophorylation of IGF-IRbeta, IRS-1 and Shc.	Benzo(a)pyrene	14-17	SHC adaptor protein 1	Homo sapiens	162-165
9683191-8	1998	In addition, both BaP and TCDD significantly increased the activity of phosphatidylinositol 3-kinase (PI3K).	Benzo(a)pyrene	18-21	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	71-100
9620885-1	1998	Glutathione (GSH) S-transferases (GSTs) have an important role in the detoxification of (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9, 10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE], which is the ultimate carcinogen of benzo[a]pyrene.	Benzo(a)pyrene	140-154	glutathione S-transferase, pi 1	Mus musculus	34-38
9663811-1	1998	AIMS: To investigate the relationship in patients with heart failure between BP response to the first dose of ACE inhibitor and (1) plasma drug concentration and (2) baseline clinical and laboratory variables.	Benzo(a)pyrene	77-79	angiotensin I converting enzyme	Homo sapiens	110-113
20654404-7	1998	Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content.	Benzo(a)pyrene	46-49	aryl hydrocarbon receptor	Rattus norvegicus	5-30
20654404-7	1998	Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content.	Benzo(a)pyrene	46-49	aryl hydrocarbon receptor	Rattus norvegicus	32-35
20654404-7	1998	Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content.	Benzo(a)pyrene	144-147	aryl hydrocarbon receptor	Rattus norvegicus	5-30
20654404-7	1998	Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content.	Benzo(a)pyrene	144-147	aryl hydrocarbon receptor	Rattus norvegicus	32-35
9605752-0	1998	Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.	Benzo(a)pyrene	139-153	caspase 1	Mus musculus	41-76
9605752-0	1998	Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.	Benzo(a)pyrene	139-153	caspase 3	Mus musculus	93-102
9605752-0	1998	Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.	Benzo(a)pyrene	139-153	mitogen-activated protein kinase 8	Mus musculus	108-135
9605752-6	1998	Importantly, at the apoptosis-inducing concentrations, BaP also induced the activation of an ICE/Ced-3 cysteine protease caspase-3 but not caspase-1 (ICE).	Benzo(a)pyrene	55-58	caspase 1	Mus musculus	93-96
9605752-6	1998	Importantly, at the apoptosis-inducing concentrations, BaP also induced the activation of an ICE/Ced-3 cysteine protease caspase-3 but not caspase-1 (ICE).	Benzo(a)pyrene	55-58	caspase 3	Mus musculus	121-130
9605752-6	1998	Importantly, at the apoptosis-inducing concentrations, BaP also induced the activation of an ICE/Ced-3 cysteine protease caspase-3 but not caspase-1 (ICE).	Benzo(a)pyrene	55-58	caspase 1	Mus musculus	139-148
9605752-6	1998	Importantly, at the apoptosis-inducing concentrations, BaP also induced the activation of an ICE/Ced-3 cysteine protease caspase-3 but not caspase-1 (ICE).	Benzo(a)pyrene	55-58	caspase 1	Mus musculus	150-153
9605752-7	1998	The activation of caspase-3 by BaP preceded apoptosis.	Benzo(a)pyrene	31-34	caspase 3	Mus musculus	18-27
9605752-8	1998	Furthermore, a specific inhibitor of caspase-3-like proteases, acetyl-Asp-Glu-Val-Asp-aldehyde, significantly blocked caspase-3 activity and attenuated apoptosis induced by BaP.	Benzo(a)pyrene	173-176	caspase 3	Mus musculus	37-46
9605752-8	1998	Furthermore, a specific inhibitor of caspase-3-like proteases, acetyl-Asp-Glu-Val-Asp-aldehyde, significantly blocked caspase-3 activity and attenuated apoptosis induced by BaP.	Benzo(a)pyrene	173-176	caspase 3	Mus musculus	118-127
9605752-9	1998	Treatment with BaP also caused a time- and dose-dependent activation of JNK1 activity.	Benzo(a)pyrene	15-18	mitogen-activated protein kinase 8	Mus musculus	72-76
9605752-11	1998	In summary, our results demonstrate that BaP induced apoptosis in the mouse hepatoma Hepa1c1c7 cell line via a caspase-dependent pathway, which may be independent of JNK activation.	Benzo(a)pyrene	41-44	caspase 1	Mus musculus	111-118
9605752-11	1998	In summary, our results demonstrate that BaP induced apoptosis in the mouse hepatoma Hepa1c1c7 cell line via a caspase-dependent pathway, which may be independent of JNK activation.	Benzo(a)pyrene	41-44	mitogen-activated protein kinase 8	Mus musculus	166-169
9606968-12	1998	For example, mGSTA1, but not mGSTA2, subunit expression was observed in the skin, which is a target organ for benzo(a)pyrene (BP)-induced cancer in mice.	Benzo(a)pyrene	126-128	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	13-19
9596073-12	1998	The data demonstrate that TGF-beta1 expression in the contralateral kidney in 2-K 1-C rats is regulated by the increase in systemic BP rather than by direct effects of angiotensin II.	Benzo(a)pyrene	132-134	transforming growth factor, beta 1	Rattus norvegicus	26-35
9494123-2	1998	The mammary carcinogens 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (BaP), respectively, increased and decreased 16alpha-/2-OHE1 ratios at some concentrations.	Benzo(a)pyrene	66-80	ATPase H+ transporting accessory protein 1	Homo sapiens	126-133
9494123-2	1998	The mammary carcinogens 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (BaP), respectively, increased and decreased 16alpha-/2-OHE1 ratios at some concentrations.	Benzo(a)pyrene	82-85	ATPase H+ transporting accessory protein 1	Homo sapiens	126-133
9555654-2	1998	Because cytochrome P-450-dependent arachidonate metabolites participate in the regulation of renal sodium transport and BP, this study tested the hypothesis that these renal responses to acute hypertension would be prevented if cytochrome P-450 metabolism were inhibited by cobalt chloride (CoCl2).	Benzo(a)pyrene	120-122	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	8-24
9555654-2	1998	Because cytochrome P-450-dependent arachidonate metabolites participate in the regulation of renal sodium transport and BP, this study tested the hypothesis that these renal responses to acute hypertension would be prevented if cytochrome P-450 metabolism were inhibited by cobalt chloride (CoCl2).	Benzo(a)pyrene	120-122	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	228-244
9525277-3	1998	In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene.	Benzo(a)pyrene	258-272	glutathione S-transferase pi 1	Homo sapiens	67-74
9644602-11	1998	These results suggest that PAMP/BP could be considered the first choice in the treatment of infectious diseases in pediatrics, due to its effectiveness and high level of safety.	Benzo(a)pyrene	32-34	adrenomedullin	Homo sapiens	27-31
20654398-5	1998	The aryl hydrocarbon receptor agonists upregulated hepatocyte GSH levels by 24 hr, a response which in the case of BaP was preceded by varying degrees of GSH depletion between 6 to 16 hr.	Benzo(a)pyrene	115-118	aryl hydrocarbon receptor	Rattus norvegicus	4-29
9532348-2	1998	Catalano et al reported an association between delusional disorder and the number of a 12-nucleotide (bp) repeat sequence in the first exon of dopamine D4 receptor gene (DRD4), which indicated a possible role of this polymorphism in the pathogenesis of psychotic disorders.	Benzo(a)pyrene	102-104	dopamine receptor D4	Homo sapiens	143-163
9532348-2	1998	Catalano et al reported an association between delusional disorder and the number of a 12-nucleotide (bp) repeat sequence in the first exon of dopamine D4 receptor gene (DRD4), which indicated a possible role of this polymorphism in the pathogenesis of psychotic disorders.	Benzo(a)pyrene	102-104	dopamine receptor D4	Homo sapiens	170-174
9558445-3	1998	COX-2 is highly inducible by endotoxin, IL-1, hypoxia, epidermal growth factor (EGF), benzo[a]pyrene, and transforming growth factor beta 1(TGF-beta 1).	Benzo(a)pyrene	86-100	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
9513899-5	1998	Continuous infusion of Ang II (1000 ng/kg per min, intravenously) to conscious rats rapidly increased BP, followed by the rapid and transient activation of glomerular p42 and p44 ERK and p46 and p55 JNK with the peak at 15 to 180 min.	Benzo(a)pyrene	102-104	angiotensinogen	Rattus norvegicus	23-29
9468547-14	1998	Thus, BP-induced aberrant proliferation is inhibited by the natural phytochemicals in part due to regulation of cell cycle progression and induction of p53 dependent apoptosis.	Benzo(a)pyrene	6-8	tumor protein p53	Homo sapiens	152-155
9524044-18	1998	We therefore conclude that ACE inhibitor treatment withdrawal is accompanied by a rapid rise in BP (within 48 h), followed by a 5-day BP plateau that is lower than the initial level.	Benzo(a)pyrene	96-98	angiotensin I converting enzyme	Homo sapiens	27-30
9488590-3	1998	The geometric mean of benzo(a)pyrene air measurements (an index compound of PAH levels) was 70 times higher in traffic police officers (3.67 ng/m3) than in referents (0.05 ng/m3).	Benzo(a)pyrene	22-36	phenylalanine hydroxylase	Homo sapiens	76-79
9472715-4	1998	Immunohistochemical detection of p53 protein showed positive cells in human skin after UV-irradiation, in mouse skin after benzo[a]pyrene treatment and in mouse spleen, thymus and bone after gamma-irradiation.	Benzo(a)pyrene	123-137	tumor protein p53	Homo sapiens	33-36
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Benzo(a)pyrene	309-323	glutathione S-transferase pi 1	Homo sapiens	94-99
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Benzo(a)pyrene	309-323	glutathione S-transferase pi 1	Homo sapiens	115-122
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Benzo(a)pyrene	309-323	glutathione S-transferase pi 1	Homo sapiens	242-249
9442066-14	1998	273, 2241-2248) and similar data for wild-type and mutant peroxidases of plant and fungal origin suggests (i) a proton-induced conformational change from an inactive BP 1 at neutral pH to a low activity BP 1 form with a functional distal histidine and (ii) a Ca(2+)-induced slow conformational change (at least compared with compound I formation) of this low activity form to a high activity BP 1 with a typical peroxidase reactivity.	Benzo(a)pyrene	166-168	prx7	Hordeum vulgare	58-68
9442066-14	1998	273, 2241-2248) and similar data for wild-type and mutant peroxidases of plant and fungal origin suggests (i) a proton-induced conformational change from an inactive BP 1 at neutral pH to a low activity BP 1 form with a functional distal histidine and (ii) a Ca(2+)-induced slow conformational change (at least compared with compound I formation) of this low activity form to a high activity BP 1 with a typical peroxidase reactivity.	Benzo(a)pyrene	203-205	prx7	Hordeum vulgare	58-68
9448724-3	1998	In contrast, this AHR-deficient line expressed a 4S protein which efficiently binds BP as it does in hepatic cytosol from C57BL/6 mice.	Benzo(a)pyrene	84-86	aryl-hydrocarbon receptor	Mus musculus	18-21
9448724-4	1998	In vivo BP exposure in AHR-deficient mice proved the inability to sustain any CYP1A1 mRNA or CYP1A1 protein induction.	Benzo(a)pyrene	8-10	aryl-hydrocarbon receptor	Mus musculus	23-26
14646501-1	1998	A number of genotoxic chemicals and agents, such as benzo(a)pyrene and ultraviolet light, are able to induce nuclear accumulation of p53 protein.	Benzo(a)pyrene	52-66	tumor protein p53	Homo sapiens	133-136
9472674-4	1998	Allergen-specific serum IgE and IgG1 antibodies dominated in the Al(OH)3 group, IgG2a antibody levels to BP and rBet v 1 were markedly higher in the sera of mice exposed to CT with the allergen.	Benzo(a)pyrene	105-107	immunoglobulin heavy variable V1-9	Mus musculus	80-85
9472674-10	1998	We conclude from the present study that the induction of an immune response to BP allergen after aerosol inhalation can be directed towards a Th1- or a Th2-like response.	Benzo(a)pyrene	79-81	negative elongation factor complex member C/D, Th1l	Mus musculus	142-145
9472674-10	1998	We conclude from the present study that the induction of an immune response to BP allergen after aerosol inhalation can be directed towards a Th1- or a Th2-like response.	Benzo(a)pyrene	79-81	heart and neural crest derivatives expressed 2	Mus musculus	152-155
9443763-10	1998	The binding potential (BP) in the neocortical regions was 4-6 times higher, whereas BP in the striatum was slightly higher than that in the cerebellum, demonstrating a regional distribution in good agreement with 5-HT2A receptor densities measured in vitro.	Benzo(a)pyrene	23-25	5-hydroxytryptamine receptor 2A	Homo sapiens	213-228
9930020-2	1998	In the strain mwh x ORR;flr3/TM3, Ser the concentration of cytochrome P-450-associated enzymes necessary faetivation of many promutagens, e.g. benzo(a)pyrene is many times higher.	Benzo(a)pyrene	143-157	Cytochrome P450-9b2	Drosophila melanogaster	59-75
9631944-2	1998	Microsomal CYP1A1 activity in renal cell carcinoma (RCC) and in normal renal tissue was determined by measuring spectrofluorometrically the hydroxylation rate of benzo[a]pyrene.	Benzo(a)pyrene	162-176	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	11-17
9407059-6	1997	Hexachlorobenzene, benzo(a)pyrene, and beta-naphthoflavone were effective AHR agonists in the yeast system, and had EC50 values of 200, 40, and 20 nM, respectively, for beta-galactosidase activity induction.	Benzo(a)pyrene	19-33	aryl hydrocarbon receptor	Homo sapiens	74-77
9465551-1	1997	Since aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene (BP) and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine AHH activity in the determination of susceptibility to lung cancer.	Benzo(a)pyrene	95-109	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-34
9399673-2	1997	We report that the induction of glutathione (GSH) S-transferase pi (mGSTP1-1) by a chemo-preventive agent can be used as a reliable marker to assess its efficacy in retarding chemical carcinogenesis induced by benzo(a)pyrene (BP), which is a widespread environmental pollutant and believed to be a risk factor in human chemical carcinogenesis.	Benzo(a)pyrene	210-224	glutathione S-transferase, pi 1	Mus musculus	68-76
9399673-2	1997	We report that the induction of glutathione (GSH) S-transferase pi (mGSTP1-1) by a chemo-preventive agent can be used as a reliable marker to assess its efficacy in retarding chemical carcinogenesis induced by benzo(a)pyrene (BP), which is a widespread environmental pollutant and believed to be a risk factor in human chemical carcinogenesis.	Benzo(a)pyrene	226-228	glutathione S-transferase, pi 1	Mus musculus	68-76
9399673-7	1997	Our results suggest that the induction of mGSTP1-1 may be a reliable marker for evaluating the efficacy of potential inhibitors of BP-induced cancer in a murine model.	Benzo(a)pyrene	131-133	glutathione S-transferase, pi 1	Mus musculus	42-50
9465551-1	1997	Since aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene (BP) and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine AHH activity in the determination of susceptibility to lung cancer.	Benzo(a)pyrene	111-113	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-34
9415707-0	1997	Identification of benzo[a]pyrene-inducible cis-acting elements within c-Ha-ras transcriptional regulatory sequences.	Benzo(a)pyrene	18-32	Harvey rat sarcoma virus oncogene	Mus musculus	70-78
9415707-1	1997	Previous studies in this laboratory have demonstrated that transcriptional deregulation of c-Ha-ras expression is associated with the induction and maintenance of proliferative vascular smooth muscle cell (SMC) phenotypes by benzo[a]pyrene (BaP).	Benzo(a)pyrene	225-239	Harvey rat sarcoma virus oncogene	Mus musculus	91-99
9415707-1	1997	Previous studies in this laboratory have demonstrated that transcriptional deregulation of c-Ha-ras expression is associated with the induction and maintenance of proliferative vascular smooth muscle cell (SMC) phenotypes by benzo[a]pyrene (BaP).	Benzo(a)pyrene	241-244	Harvey rat sarcoma virus oncogene	Mus musculus	91-99
9415707-2	1997	We examined previously undescribed cis-acting elements within the proximal 5" regulatory region of c-Ha-ras (-550 to +220) for their ability to influence BaP-induced transcription in murine SMCs.	Benzo(a)pyrene	154-157	Harvey rat sarcoma virus oncogene	Mus musculus	99-107
9415707-3	1997	BaP-inducible DNA binding activity was demonstrated at a site located -30 relative to the major start site cluster at +1 that exhibits extensive homology to a consensus aryl hydrocarbon response element (AHRE), as well as a site located at -543 that contains a consensus electrophile response element (EpRE).	Benzo(a)pyrene	0-3	aryl-hydrocarbon receptor	Mus musculus	204-208
9415707-5	1997	The use of monoclonal antibodies to the aryl hydrocarbon receptor transcription factor in competition electrophoretic mobility shift assays indicated this protein is specifically induced by BaP to interact at the AHRE within the c-Ha-ras 5" regulatory region.	Benzo(a)pyrene	190-193	aryl-hydrocarbon receptor	Mus musculus	213-217
9415707-5	1997	The use of monoclonal antibodies to the aryl hydrocarbon receptor transcription factor in competition electrophoretic mobility shift assays indicated this protein is specifically induced by BaP to interact at the AHRE within the c-Ha-ras 5" regulatory region.	Benzo(a)pyrene	190-193	Harvey rat sarcoma virus oncogene	Mus musculus	229-237
9415707-8	1997	These data indicate that c-Ha-ras gene expression is modulated by BaP via a complex mechanism that likely involves interactions among multiple regulatory elements.	Benzo(a)pyrene	66-69	Harvey rat sarcoma virus oncogene	Mus musculus	25-33
9371491-2	1997	Myeloperoxidase activates benzo[a]pyrene as well as aromatic amines in tobacco smoke and generates carcinogen-free radicals.	Benzo(a)pyrene	26-40	myeloperoxidase	Homo sapiens	0-15
9374853-9	1997	For the latter case, the aromatic portion of the BP residue stacks over the adjacent dC5.dG22 base pair, the modified deoxyguanosine adopts a syn glycosidic torsion angle and is displaced toward the major groove direction.	Benzo(a)pyrene	49-51	synemin	Homo sapiens	142-145
9395218-8	1997	Benzo[a]pyrene induced GSTA3 and UGT in regeneration vs Cyp1A, Cyp2B, GSTA1/2, GSTA3, GSTA4, GSTP1 and UGT in control normal intestinal epithelium.	Benzo(a)pyrene	0-14	glutathione S-transferase alpha 3	Rattus norvegicus	23-28
9395218-9	1997	Benzo[a]pyrene induced low levels of GSTA3 in early regenerating intestinal epithelium but induction increased by >2-fold at late stage regeneration.	Benzo(a)pyrene	0-14	glutathione S-transferase alpha 3	Rattus norvegicus	37-42
9395224-9	1997	Furthermore, Bcl-2 oncoprotein was also upregulated approximately 8- and 11-fold for BaP and DEHP respectively; meanwhile Bcl-xL protein rate did not change.	Benzo(a)pyrene	85-88	apoptosis regulator Bcl-2	Mesocricetus auratus	13-18
9341155-3	1997	Recently, evidence has been provided to show that GNMT is identical to the cytosolic receptor for benzo[a]pyrene, which induces cytochrome P450 1A1 gene expression.	Benzo(a)pyrene	98-112	glycine N-methyltransferase	Rattus norvegicus	50-54
9341155-3	1997	Recently, evidence has been provided to show that GNMT is identical to the cytosolic receptor for benzo[a]pyrene, which induces cytochrome P450 1A1 gene expression.	Benzo(a)pyrene	98-112	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	128-147
11596290-8	1997	The effects of SY-640 on cytochrome P-450 and its formation of MI complex with cytochrome P-450 may partially explain why SY-640 could inhibit covalent-binding of BP to mouse hepatocyte DNA in vitro.	Benzo(a)pyrene	163-165	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	25-41
9269322-0	1997	Differential carcinogenicity of benzo[a]pyrene in male and female CD-1 mouse lung.	Benzo(a)pyrene	32-46	CD1 antigen complex	Mus musculus	66-70
9269322-5	1997	Results of these studies show that the female CD-1 mice are more susceptibile to the carcinogenic effect of BaP than the males and that the attenuation of BaP-induced carcinogenesis by BHA appears to be restricted only to the females.	Benzo(a)pyrene	108-111	CD1 antigen complex	Mus musculus	46-50
9446322-4	1997	The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.	Benzo(a)pyrene	32-34	interleukin 2	Rattus norvegicus	42-46
11596290-8	1997	The effects of SY-640 on cytochrome P-450 and its formation of MI complex with cytochrome P-450 may partially explain why SY-640 could inhibit covalent-binding of BP to mouse hepatocyte DNA in vitro.	Benzo(a)pyrene	163-165	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	79-95
9261130-9	1997	Cytosolic preparations from the CHO-GNMT showed high benzo[a]pyrene (B[a]P) binding but no 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) binding activity when compared with clones transfected with the pMAMneo vector alone (CHO-neo) or the parental CHO cells.	Benzo(a)pyrene	69-74	glycine N-methyltransferase	Cricetulus griseus	36-40
9256462-2	1997	In Saccharomyces cerevisiae, removal of nonhomologous ends depends not only on the nucleotide excision repair endonuclease Rad1/Rad10 but also on Msh2 and Msh3, two proteins that are required to correct mismatched bp.	Benzo(a)pyrene	214-216	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	123-127
9256462-2	1997	In Saccharomyces cerevisiae, removal of nonhomologous ends depends not only on the nucleotide excision repair endonuclease Rad1/Rad10 but also on Msh2 and Msh3, two proteins that are required to correct mismatched bp.	Benzo(a)pyrene	214-216	DNA repair protein RAD10	Saccharomyces cerevisiae S288C	128-133
9256462-2	1997	In Saccharomyces cerevisiae, removal of nonhomologous ends depends not only on the nucleotide excision repair endonuclease Rad1/Rad10 but also on Msh2 and Msh3, two proteins that are required to correct mismatched bp.	Benzo(a)pyrene	214-216	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	146-150
9256462-2	1997	In Saccharomyces cerevisiae, removal of nonhomologous ends depends not only on the nucleotide excision repair endonuclease Rad1/Rad10 but also on Msh2 and Msh3, two proteins that are required to correct mismatched bp.	Benzo(a)pyrene	214-216	mismatch repair protein MSH3	Saccharomyces cerevisiae S288C	155-159
9256462-7	1997	We suggest Msh2 and Msh3 recognize not only heteroduplex loops and mismatched bp, but also branched DNA structures with a free 3" tail.	Benzo(a)pyrene	78-80	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	11-15
9256462-7	1997	We suggest Msh2 and Msh3 recognize not only heteroduplex loops and mismatched bp, but also branched DNA structures with a free 3" tail.	Benzo(a)pyrene	78-80	mismatch repair protein MSH3	Saccharomyces cerevisiae S288C	20-24
9245423-6	1997	Here we report a systematic study of the oligomeric state of GNMT in the presence of benzo[a]pyrene (B[a]P) in vivo and in vitro.	Benzo(a)pyrene	85-99	glycine N-methyltransferase	Rattus norvegicus	61-65
9245423-6	1997	Here we report a systematic study of the oligomeric state of GNMT in the presence of benzo[a]pyrene (B[a]P) in vivo and in vitro.	Benzo(a)pyrene	101-106	glycine N-methyltransferase	Rattus norvegicus	61-65
9272928-1	1997	MDR1 P-glycoprotein (Pgp 170), a member of the adenosine triphosphate (ATP) binding cassette transporters, acts as an efflux pump for various hydrophobic agents, particularly for xenobiotics such as benzo(a)pyrene.	Benzo(a)pyrene	199-213	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
9272928-1	1997	MDR1 P-glycoprotein (Pgp 170), a member of the adenosine triphosphate (ATP) binding cassette transporters, acts as an efflux pump for various hydrophobic agents, particularly for xenobiotics such as benzo(a)pyrene.	Benzo(a)pyrene	199-213	ATP binding cassette subfamily B member 1	Homo sapiens	5-19
9272928-1	1997	MDR1 P-glycoprotein (Pgp 170), a member of the adenosine triphosphate (ATP) binding cassette transporters, acts as an efflux pump for various hydrophobic agents, particularly for xenobiotics such as benzo(a)pyrene.	Benzo(a)pyrene	199-213	phosphoglycolate phosphatase	Homo sapiens	21-24
21528215-1	1997	Cytochrome p4501A1 gene (CYP1A1) and glutathione S-transferase mu gene (GSTM1) are involved in the metabolic activation or detoxification of environmental carcinogens including benzo[a]pyrene in tobacco smoke.	Benzo(a)pyrene	177-191	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31
9314051-0	1997	P53 mutations in tumours induced by intraperitoneal injection of crocidolite asbestos and benzo[a]pyrene in rats.	Benzo(a)pyrene	90-104	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
9314051-2	1997	In tumours induced by benzo[a]pyrene a considerable amount of p53 mutations resulting in an altered protein structure could be detected.	Benzo(a)pyrene	22-36	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	62-65
21528215-1	1997	Cytochrome p4501A1 gene (CYP1A1) and glutathione S-transferase mu gene (GSTM1) are involved in the metabolic activation or detoxification of environmental carcinogens including benzo[a]pyrene in tobacco smoke.	Benzo(a)pyrene	177-191	glutathione S-transferase mu 1	Homo sapiens	72-77
9288883-1	1997	Dibenzo[a,l]pyrene (DBP) has recently emerged as a potent environmental carcinogen having greater carcinogenicity in the rat mammary epithelial glands than 7,12-dimethylbenz[a]anthracene (DMBA), previously considered to be the most potent mammary carcinogen and benzo[a]pyrene (BP), a ubiquitous environmental carcinogen.	Benzo(a)pyrene	262-276	D-box binding PAR bZIP transcription factor	Rattus norvegicus	20-23
9263210-8	1997	The hypotensive effects observed in response to VP microinjection into SFO were abolished by systemic treatment with a V1 receptor antagonist (mean AUC 89.5 +/- 67.7 mm Hg.s, p > 0.05) compared to BP response before V1 receptor blockade (mean AUC -605.9 +/- 119.8 mm Hg.s, n = 4).	Benzo(a)pyrene	200-202	arginine vasopressin	Rattus norvegicus	48-50
9288883-2	1997	Previous studies on the tumor-initiating potential of DBP, DMBA, and BP demonstrated that DBP was 2.5 times more potent in inducing the tumors in mouse skin and rat mammary glands than DMBA; BP was a weak mammary carcinogen in these animals.	Benzo(a)pyrene	55-57	D site albumin promoter binding protein	Mus musculus	90-93
9266805-4	1997	In a series of studies with HPBMC obtained from 10 donors exposed in vitro for 42 hr, BaP and DMBA were found to produce a significant increase in Ca2+ in CD3+ T cells, CD19+ B cells, and CD14+ monocytes.	Benzo(a)pyrene	86-89	CD19 molecule	Homo sapiens	169-173
9266805-4	1997	In a series of studies with HPBMC obtained from 10 donors exposed in vitro for 42 hr, BaP and DMBA were found to produce a significant increase in Ca2+ in CD3+ T cells, CD19+ B cells, and CD14+ monocytes.	Benzo(a)pyrene	86-89	CD14 molecule	Homo sapiens	188-192
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	Benzo(a)pyrene	302-316	glutathione S-transferase pi 1	Homo sapiens	113-120
9219573-0	1997	Mutant frequency of lacI in transgenic mice following benzo[a]pyrene treatment and partial hepatectomy.	Benzo(a)pyrene	54-68	tissue factor pathway inhibitor	Mus musculus	20-24
9182810-6	1997	Epitope mapping with rBP55, a fusion protein containing the C-terminal end of BPAg1, suggested that the major antigenic epitopes for LABD and BP antibodies on the 230-kDa antigen are different.	Benzo(a)pyrene	22-24	dystonin	Homo sapiens	78-83
9245072-5	1997	ACE inhibitors moreover reduce glomerular filtration and albuminuria and thus retard along with the effect on BP the progression of diabetic nephropathy.	Benzo(a)pyrene	110-112	angiotensin I converting enzyme	Homo sapiens	0-3
9217241-0	1997	Effect of the route of benzo[a]pyrene administration on sister chromatid exchange and DNA binding in bone marrow of mice differing with respect to cytochrome P450 1A1 induction.	Benzo(a)pyrene	23-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	147-166
9151440-7	1997	value of Benzo[a]pyrene [BaP] was 0.37 +/- 0.15 ng m-3 in winter and 0.12 +/- 0.07 ng m-3 in summer.	Benzo(a)pyrene	9-23	prohibitin 2	Homo sapiens	25-28
9152602-5	1997	CYP1B1 catalyzed benzo[a]pyrene 3-hydroxylation at rates lower than those of CYP1A1 but higher than those of CYP1A2.	Benzo(a)pyrene	17-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
9152602-5	1997	CYP1B1 catalyzed benzo[a]pyrene 3-hydroxylation at rates lower than those of CYP1A1 but higher than those of CYP1A2.	Benzo(a)pyrene	17-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
9133601-4	1997	Similar to our previous observation with dimethylnitrosamine- and benzo[a] pyrene-induced lung tumors, K-ras mRNA transcribed from A/J allele was 10-40-times more abundant than those from C57BL/6J allele in all of 40 (A/J x TSG-p53) F1 mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	Benzo(a)pyrene	66-81	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	103-108
9170146-2	1997	AHR ligands include 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin), benzo[a]pyrene, and polychlorinated and polybrominated biphenyls; the endogenous ligand is not yet known.	Benzo(a)pyrene	72-86	aryl hydrocarbon receptor	Homo sapiens	0-3
9050836-9	1997	Recombinant human QR2: (i) reacts with N-ribosyl- and N-alkyldihydronicotinamides, but not with NADH, NADPH, or NMNH; (ii) is very weakly inhibited by dicumarol or Cibacron blue; (iii) is very potently inhibited by benzo[a]pyrene.	Benzo(a)pyrene	215-229	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	18-21
9172946-6	1997	The contents of CYP2B1 and 3A2 in rat hepatic microsomes of the BP group measured by immunoblotting were significantly higher than those of the UT group.	Benzo(a)pyrene	64-66	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	16-22
9065823-0	1997	Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene.	Benzo(a)pyrene	115-129	catalase	Rattus norvegicus	84-92
9048959-2	1997	The partial decrease in cytochrome P-450 content indicated altered levels of the P-450 isozymes, which may have profound effects on the metabolic disposition of benzo[a]pyrene [BaP].	Benzo(a)pyrene	161-175	prohibitin 2	Rattus norvegicus	177-180
9070231-0	1997	Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells.	Benzo(a)pyrene	0-14	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-96
9070231-3	1997	TCDD and BaP both showed induction of cytochrome P450 1A1 (CYP1A1), whereas only BaP caused a significant loss of EGFRs.	Benzo(a)pyrene	9-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-57
9070231-3	1997	TCDD and BaP both showed induction of cytochrome P450 1A1 (CYP1A1), whereas only BaP caused a significant loss of EGFRs.	Benzo(a)pyrene	9-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
9070231-4	1997	Exposure to 10 microM BaP significantly increased the steady state mRNA level of transforming growth factor (TGF)-beta 1, while the c-myc mRNA levels were decreased by 61%.	Benzo(a)pyrene	22-25	transforming growth factor beta 1	Homo sapiens	81-120
9070231-4	1997	Exposure to 10 microM BaP significantly increased the steady state mRNA level of transforming growth factor (TGF)-beta 1, while the c-myc mRNA levels were decreased by 61%.	Benzo(a)pyrene	22-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	132-137
9183562-6	1997	Results obtained in treated MAS tests indicated that BAP was predominantly activated by Cytochrome P-450 isozyme CYP1A1.	Benzo(a)pyrene	53-56	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	113-119
9070358-2	1997	Cellular expression of BP-inducible cytochrome P4501A (CYP1A) was evaluated several times during exposure by immunohistochemistry in longitudinal histologic sections of whole fish.	Benzo(a)pyrene	23-25	cytochrome P450 1A1	Fundulus heteroclitus	55-60
9070358-4	1997	Exposure to aqueous BP resulted in high levels of CYP1A-associated immunohistochemical staining in gill pillar cells, heart endothelium, and vascular endothelium.	Benzo(a)pyrene	20-22	cytochrome P450 1A1	Fundulus heteroclitus	50-55
8999837-1	1997	Previous work has shown that polycyclic aromatic hydrocarbons and oltipraz both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyrene-7, 8-diol, the proximate carcinogenic form of benzo(a)pyrene.	Benzo(a)pyrene	162-176	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	113-140
9006915-0	1997	A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts.	Benzo(a)pyrene	2-16	transformation related protein 53, pseudogene	Mus musculus	60-63
9006915-2	1997	Although physiological ligands for the AhR have not been identified, carcinogenic polycyclic aromatic hydrocarbons such as Benzo[a]pyrene (B[a]P) are high affinity AhR ligands that induce nuclear translocation and sequence-specific DNA binding of the AhR.	Benzo(a)pyrene	123-137	aryl-hydrocarbon receptor	Mus musculus	39-42
9006915-2	1997	Although physiological ligands for the AhR have not been identified, carcinogenic polycyclic aromatic hydrocarbons such as Benzo[a]pyrene (B[a]P) are high affinity AhR ligands that induce nuclear translocation and sequence-specific DNA binding of the AhR.	Benzo(a)pyrene	123-137	aryl-hydrocarbon receptor	Mus musculus	164-167
9006915-2	1997	Although physiological ligands for the AhR have not been identified, carcinogenic polycyclic aromatic hydrocarbons such as Benzo[a]pyrene (B[a]P) are high affinity AhR ligands that induce nuclear translocation and sequence-specific DNA binding of the AhR.	Benzo(a)pyrene	123-137	aryl-hydrocarbon receptor	Mus musculus	164-167
8967965-1	1996	Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	5-19	aryl-hydrocarbon receptor	Mus musculus	190-215
8951352-5	1996	Cytochrome P450 monooxygenase activity toward benzo-[a]pyrene was increased in kidney 4 hr after treatment, whereas dealkylation of 7-methoxycoumarin or 7-ethoxyresorufin was unchanged in any tissue at either time point.	Benzo(a)pyrene	46-61	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	0-29
9006115-0	1996	Site-specific modification of the human N-ras proto-oncogene with each diol epoxide metabolite of benzo[a]pyrene and thermal denaturation studies of the adducted duplexes.	Benzo(a)pyrene	98-112	NRAS proto-oncogene, GTPase	Homo sapiens	40-45
8967965-1	1996	Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	159-165
9014198-1	1996	The metabolism of benzo[a]pyrene (B[a]P) and its proximate mutagen B[a]P-7,8-dihydrodiol (7,8-diol) was investigated in the presence of human microsomal epoxide hydrolase and P450 1A1, 1A2, 2C8, 2C9, 2C18, 2C19, 2D6 and 3A4 expressed in the yeast Saccharomyces cerevisiae.	Benzo(a)pyrene	18-32	epoxide hydrolase 1	Homo sapiens	142-170
8967965-1	1996	Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	5-19	aryl-hydrocarbon receptor	Mus musculus	217-220
9051119-0	1996	Cell proliferation and nuclear abnormalities are increased and apoptosis is decreased in the epidermis of the p53 null mouse after topical application of benzo[a]pyrene.	Benzo(a)pyrene	154-168	transformation related protein 53, pseudogene	Mus musculus	110-113
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	jun proto-oncogene	Mus musculus	138-153
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	FBJ osteosarcoma oncogene	Mus musculus	169-174
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	jun proto-oncogene	Mus musculus	176-181
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	jun B proto-oncogene	Mus musculus	183-187
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	jun D proto-oncogene	Mus musculus	193-197
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	jun proto-oncogene	Mus musculus	284-288
8917696-2	1996	In a previous study, we have shown that treatment of mouse hepatoma cells with TCDD or B(a)P results in an increase in mRNA levels of the immediate-early protooncogenes c-fos, c-jun, junB, and junD, and the concomitant increase of the DNA-binding activity of the transcription factor AP-1, a dimer of FOS and JUN proteins.	Benzo(a)pyrene	87-92	FBJ osteosarcoma oncogene	Mus musculus	301-304
8921980-9	1996	It was concluded that structural requirements for AhR affinity are the same as those required for metabolism by enzymes that bioactivate benzo(a)pyrene.	Benzo(a)pyrene	137-151	aryl hydrocarbon receptor	Homo sapiens	50-53
8832894-0	1996	Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.	Benzo(a)pyrene	26-40	tumor protein p53	Homo sapiens	87-90
8895489-1	1996	Human lung cancer exhibits a high frequency of transversion mutations at G:C base pairs of the p53 gene, possibly the result of DNA damage by cigarette smoke constituents, most notably benzo[a]pyrene.	Benzo(a)pyrene	185-199	tumor protein p53	Homo sapiens	95-98
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	36-38	complement C3	Homo sapiens	132-135
8933030-5	1996	Studies are presented that demonstrate that high ambient levels of benzo[a]pyrene are associated with high levels of DNA adducts in human blood cell DNA and that the same DNA adduct levels drop when the ambient PAH levels decrease significantly.	Benzo(a)pyrene	67-81	phenylalanine hydroxylase	Homo sapiens	211-214
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	36-38	complement C4A (Rodgers blood group)	Homo sapiens	137-140
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	36-38	complement C5	Homo sapiens	146-149
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	56-58	complement C3	Homo sapiens	132-135
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	56-58	complement C4A (Rodgers blood group)	Homo sapiens	137-140
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	56-58	complement C5	Homo sapiens	146-149
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	56-58	complement C3	Homo sapiens	132-135
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	56-58	complement C4A (Rodgers blood group)	Homo sapiens	137-140
8870993-8	1996	Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding.	Benzo(a)pyrene	56-58	complement C5	Homo sapiens	146-149
8759031-4	1996	Exposure of cultured GMCs to BaP (30 microM) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 10 nM) for 24 hr induced CYP1A1 mRNA levels, a response abolished by cotreatment with 10 microM cycloheximide.	Benzo(a)pyrene	29-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	116-122
8759031-5	1996	The pattern of hydrocarbon inducibility was atypical in that BaP was a more effective inducer of CYP1A1 gene expression than TCDD, and both hydrocarbons induced aryl hydrocarbon hydroxylase (AHH) activity, but not ethoxyresorufin-O-deethylase activity.	Benzo(a)pyrene	61-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-103
8759031-1	1996	Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism.	Benzo(a)pyrene	67-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
8759031-1	1996	Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism.	Benzo(a)pyrene	67-81	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
8759031-5	1996	The pattern of hydrocarbon inducibility was atypical in that BaP was a more effective inducer of CYP1A1 gene expression than TCDD, and both hydrocarbons induced aryl hydrocarbon hydroxylase (AHH) activity, but not ethoxyresorufin-O-deethylase activity.	Benzo(a)pyrene	61-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	191-194
8759031-6	1996	Cotreatment with alpha-naphthoflavone (alpha NF, 1 microM) or ellipticine (ELLIP, 0.1 nM) only partially inhibited the induction of AHH activity by BaP (30 microM).	Benzo(a)pyrene	148-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-135
8759031-7	1996	BaP and TCDD also induced expression of the CYP1B1 protein and the pattern of induction was comparable to that observed for CYP1A1.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-50
8759031-9	1996	These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA.	Benzo(a)pyrene	91-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
8759031-9	1996	These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA.	Benzo(a)pyrene	91-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	42-48
8759031-9	1996	These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA.	Benzo(a)pyrene	156-159	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
8759031-9	1996	These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA.	Benzo(a)pyrene	156-159	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	42-48
8806728-1	1996	Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP), have been implicated in the initiation and progression of vascular lesions of atherosclerotic morphology in laboratory animals.	Benzo(a)pyrene	42-56	prohibitin 2	Rattus norvegicus	58-61
8706015-1	1996	CYP1A1 is responsible for the metabolic activation of benzo(a)pyrene in cigarette smoke, and high susceptibility to smoking-related lung cancer has been associated with the MspI polymorphism of the CYP1A1 gene.	Benzo(a)pyrene	54-68	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
8706015-1	1996	CYP1A1 is responsible for the metabolic activation of benzo(a)pyrene in cigarette smoke, and high susceptibility to smoking-related lung cancer has been associated with the MspI polymorphism of the CYP1A1 gene.	Benzo(a)pyrene	54-68	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	198-204
8806846-1	1996	The detailed urinary excretion profiles of 1-hydroxypyrene (1-OHP) and benzo(a)pyrene (BaP) metabolites were studied following acute intravenous administration of pyrene and BaP, respectively, or after injection of the metabolites themselves.	Benzo(a)pyrene	71-85	prohibitin 2	Rattus norvegicus	87-90
8902877-4	1996	Oral administration of TMK688 (30 mg/kg) almost completely suppressed Cyp1a1 mRNA levels in mouse epidermis induced by a topical application of MC (40 mg/kg) or benzo[a]pyrene (200 nmol) to mouse skin.	Benzo(a)pyrene	161-175	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	70-76
8853452-0	1996	Binding and transport of benzo[a]pyrene by blood plasma lipoproteins: the possible role of apolipoprotein B in this process.	Benzo(a)pyrene	25-39	apolipoprotein B	Rattus norvegicus	91-107
8755554-4	1996	We studied the differences between single and chronic topical application of benzo[a]pyrene (BAP) on the accumulation and removal of BAP-DNA adducts in skin, lung, and liver.	Benzo(a)pyrene	77-91	prohibitin 2	Homo sapiens	93-96
8755554-4	1996	We studied the differences between single and chronic topical application of benzo[a]pyrene (BAP) on the accumulation and removal of BAP-DNA adducts in skin, lung, and liver.	Benzo(a)pyrene	77-91	prohibitin 2	Homo sapiens	133-136
8853452-11	1996	After isolation and purification of apolipoprotein B, the equilibrium dissociation constant for complexes of benzo[a]pyrene with apolipoprotein B was obtained, and its value indicated that apolipoprotein B might be the main protein carrier for benzo[a]pyrene.	Benzo(a)pyrene	109-123	apolipoprotein B	Rattus norvegicus	36-52
8853452-11	1996	After isolation and purification of apolipoprotein B, the equilibrium dissociation constant for complexes of benzo[a]pyrene with apolipoprotein B was obtained, and its value indicated that apolipoprotein B might be the main protein carrier for benzo[a]pyrene.	Benzo(a)pyrene	109-123	apolipoprotein B	Rattus norvegicus	129-145
8853452-11	1996	After isolation and purification of apolipoprotein B, the equilibrium dissociation constant for complexes of benzo[a]pyrene with apolipoprotein B was obtained, and its value indicated that apolipoprotein B might be the main protein carrier for benzo[a]pyrene.	Benzo(a)pyrene	109-123	apolipoprotein B	Rattus norvegicus	129-145
8853452-11	1996	After isolation and purification of apolipoprotein B, the equilibrium dissociation constant for complexes of benzo[a]pyrene with apolipoprotein B was obtained, and its value indicated that apolipoprotein B might be the main protein carrier for benzo[a]pyrene.	Benzo(a)pyrene	244-258	apolipoprotein B	Rattus norvegicus	36-52
8853452-11	1996	After isolation and purification of apolipoprotein B, the equilibrium dissociation constant for complexes of benzo[a]pyrene with apolipoprotein B was obtained, and its value indicated that apolipoprotein B might be the main protein carrier for benzo[a]pyrene.	Benzo(a)pyrene	244-258	apolipoprotein B	Rattus norvegicus	129-145
8853452-11	1996	After isolation and purification of apolipoprotein B, the equilibrium dissociation constant for complexes of benzo[a]pyrene with apolipoprotein B was obtained, and its value indicated that apolipoprotein B might be the main protein carrier for benzo[a]pyrene.	Benzo(a)pyrene	244-258	apolipoprotein B	Rattus norvegicus	129-145
8771373-5	1996	Both AF and BP are substrates for the P-450 and flavin-containing monooxygenase enzyme system, which can be induced with beta-naphthoflavone (beta NF).	Benzo(a)pyrene	12-14	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	38-79
8963106-5	1996	The goal of the study was to clarify the question, whether the in vivo pretreatment of rats with a complex PCB pattern derived from children led to a synergism of cogenotoxicants and pregenotoxicants with regard to the enhancement of the in vitro toxification of benzo[a]pyrene (B[a]P) and 2-aminoanthracene (2-AA) to DNA reactive metabolites.	Benzo(a)pyrene	263-277	pyruvate carboxylase	Rattus norvegicus	107-110
8692887-1	1996	The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Benzo(a)pyrene	140-154	aryl-hydrocarbon receptor	Mus musculus	4-15
8692887-1	1996	The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Benzo(a)pyrene	140-154	aryl-hydrocarbon receptor	Mus musculus	17-20
8676899-1	1996	The purpose of this study was to investigate the influence of benzylisothiocyanate (BIT) and 13-cis-retinoic acid (RA) upon the genotoxic potential of benzo[a]pyrene (BaP) to induce micronucleus formation in the bone marrow of mice.	Benzo(a)pyrene	151-165	prohibitin 2	Mus musculus	167-170
8681459-0	1996	TPA decreases the p53 response to benzo[a]pyrene-DNA adducts in vivo in mouse skin.	Benzo(a)pyrene	34-48	promotion susceptibility QTL 1	Mus musculus	0-3
8681459-0	1996	TPA decreases the p53 response to benzo[a]pyrene-DNA adducts in vivo in mouse skin.	Benzo(a)pyrene	34-48	transformation related protein 53, pseudogene	Mus musculus	18-21
8681459-2	1996	A dose-dependent increase in both the level of BPDE-DNA adducts and nuclear p53 immunoreactivity was found in mice treated topically with 50-750 microg benzo[a]pyrene.	Benzo(a)pyrene	152-166	transformation related protein 53, pseudogene	Mus musculus	76-79
8728425-0	1996	Dipole source localization of MEG by BP neural networks.	Benzo(a)pyrene	37-39	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	30-33
8728425-1	1996	The purpose of this study was to examine the usefulness of BP neural network for source localization of MEG.	Benzo(a)pyrene	59-61	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	104-107
21544413-8	1996	These results are consistent with selective inhibition of CYP1A1, the isozyme involved in the conversion of BP to BP-7,8-diol.	Benzo(a)pyrene	108-110	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	58-64
8713566-6	1996	On the 3rd AT cycle for 14 days, together in 20/22 AT-treated patients, basal and fMLP-stimulated L-RLO levels become low or normal, as well as their SCs become negative (CFU/ml = 0), whilst in a third control group (group cC) of 10 not-AT-treated BP patients, through matched-follow-up observations, these L-RLO values were always elevated and their SC remained positive (CFU/ml > or = 10(5)).	Benzo(a)pyrene	248-250	formyl peptide receptor 1	Homo sapiens	82-86
8839044-1	1996	Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes.	Benzo(a)pyrene	105-119	solute carrier family 45 member 2	Homo sapiens	27-30
8839044-4	1996	A minimum kinetic model of BP metabolism by 1A1 and mEH was constructed on the basis of the overall kinetic parameters (Vmax, Km) for a number of individual steps determined with human 1A1 and mEH expressed in yeast.	Benzo(a)pyrene	27-29	solute carrier family 45 member 2	Homo sapiens	44-47
8839044-4	1996	A minimum kinetic model of BP metabolism by 1A1 and mEH was constructed on the basis of the overall kinetic parameters (Vmax, Km) for a number of individual steps determined with human 1A1 and mEH expressed in yeast.	Benzo(a)pyrene	27-29	epoxide hydrolase 1, microsomal	Mus musculus	52-55
8839044-4	1996	A minimum kinetic model of BP metabolism by 1A1 and mEH was constructed on the basis of the overall kinetic parameters (Vmax, Km) for a number of individual steps determined with human 1A1 and mEH expressed in yeast.	Benzo(a)pyrene	27-29	solute carrier family 45 member 2	Homo sapiens	185-188
8839044-4	1996	A minimum kinetic model of BP metabolism by 1A1 and mEH was constructed on the basis of the overall kinetic parameters (Vmax, Km) for a number of individual steps determined with human 1A1 and mEH expressed in yeast.	Benzo(a)pyrene	27-29	epoxide hydrolase 1, microsomal	Mus musculus	193-196
8598570-4	1996	CYP 2B1 activity, which is responsible for the metabolism of benzo[a]pyrene (BaP) to relatively nontoxic metabolites, was decreased in lung but not in liver.	Benzo(a)pyrene	61-75	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-7
8598570-4	1996	CYP 2B1 activity, which is responsible for the metabolism of benzo[a]pyrene (BaP) to relatively nontoxic metabolites, was decreased in lung but not in liver.	Benzo(a)pyrene	77-80	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-7
8598570-5	1996	The activity of CYP 1A1, responsible for the metabolism of BaP to reactive/toxic products, was not altered in lung or liver.	Benzo(a)pyrene	59-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	16-23
8598570-6	1996	The CYP 2B1/1A1 ratio is an indirect indicator of the pattern of BaP toxication/detoxication.	Benzo(a)pyrene	65-68	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	4-15
8598575-7	1996	Statistical analysis of these results indicates that the patterns of tumor ras mutations induced by BaP in CD-1 and B6C3F1 mice were indistinguishable, while 6-NC and 4-ABP produced different tumor ras profiles in the two mouse models.	Benzo(a)pyrene	100-103	CD1 antigen complex	Mus musculus	107-122
8625448-2	1996	Ellagic acid has been shown to inhibit the CYP1A1-dependent activation of benzo[a]pyrene; to bind to and detoxify the diolepoxide of benzo[a]pyrene; to bind to DNA and reduce the formation of O6-methylguanine by methylating carcinogens; and to induce the phase II detoxification enzymes glutathione S-transferase Ya and NAD(P)H:quinone reductase.	Benzo(a)pyrene	74-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
8625448-2	1996	Ellagic acid has been shown to inhibit the CYP1A1-dependent activation of benzo[a]pyrene; to bind to and detoxify the diolepoxide of benzo[a]pyrene; to bind to DNA and reduce the formation of O6-methylguanine by methylating carcinogens; and to induce the phase II detoxification enzymes glutathione S-transferase Ya and NAD(P)H:quinone reductase.	Benzo(a)pyrene	133-147	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
8729008-2	1996	One of these hemoproteins, cytochrome P4501A1, is most closely associated with the bioactivation of polycyclic aromatic hydrocarbons such as benzo[a]pyrene, which may play a role in environmental carcinogenesis.	Benzo(a)pyrene	141-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	27-45
8839044-1	1996	Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes.	Benzo(a)pyrene	105-119	epoxide hydrolase 1, microsomal	Mus musculus	66-69
8839044-1	1996	Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes.	Benzo(a)pyrene	121-123	solute carrier family 45 member 2	Homo sapiens	22-25
8839044-1	1996	Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes.	Benzo(a)pyrene	121-123	solute carrier family 45 member 2	Homo sapiens	27-30
8839044-1	1996	Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes.	Benzo(a)pyrene	121-123	epoxide hydrolase 1, microsomal	Mus musculus	66-69
8924589-0	1996	Benzo[a]pyrene-DNA adducts inhibit the DNA helicase activity of the bacteriophage T7 gene 4 protein.	Benzo(a)pyrene	0-14	helicase	Escherichia phage T7	43-51
8924589-4	1996	In the present study, we directly show that the helicase activity of the gene 4 protein is also profoundly inhibited by the benzo[a]pyrene-DNA adducts.	Benzo(a)pyrene	124-138	helicase	Escherichia phage T7	48-56
9167065-1	1996	The association of small quantities of ferric oxide with Benzo[a]Pyrene (BaP) appears to increase in vivo the toxic effect of BaP.	Benzo(a)pyrene	57-71	prohibitin 2	Rattus norvegicus	73-76
9167065-1	1996	The association of small quantities of ferric oxide with Benzo[a]Pyrene (BaP) appears to increase in vivo the toxic effect of BaP.	Benzo(a)pyrene	57-71	prohibitin 2	Rattus norvegicus	126-129
8804551-0	1996	Effect of dietary restriction on benzo[a]pyrene (BaP) metabolic activation and pulmonary BaP-DNA adduct formation in mouse.	Benzo(a)pyrene	33-47	prohibitin 2	Mus musculus	49-52
8625944-0	1996	Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8- diol-anti-9,10-epoxide.	Benzo(a)pyrene	136-150	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	82-86
8991066-6	1996	32P postlabelling revealed that the lower hprt response in BB mice correlated with lower amounts of BP-DNA adducts in spleen, liver, and lung 24 hours after B[a]P exposure.	Benzo(a)pyrene	100-102	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	42-46
8919266-2	1996	test), crocidolite and benzo[a]pyrene, both caused a progression from initially reactive, then autonomously transformed proliferation of myofibroblasts and undifferentiated mesenchymal cells to malignant, multidirectionally differentiated (desmin and ED-1 positive) fibro-histiocytic tumours.	Benzo(a)pyrene	23-37	ectodysplasin A	Homo sapiens	251-255
9819666-7	1996	In addition, when the intraperitoneal macrophages obtained from the normal mice (unimmunized mice) were incubated with pyrene, anthracene, fluoranthene or benzo(a)pyrene in vitro, an enhanced chemiluminescence (CI) response and interleukin-1 alpha (IL-1 alpha) production of the macrophages was observed in each instance.	Benzo(a)pyrene	155-169	interleukin 1 alpha	Mus musculus	228-247
9819666-7	1996	In addition, when the intraperitoneal macrophages obtained from the normal mice (unimmunized mice) were incubated with pyrene, anthracene, fluoranthene or benzo(a)pyrene in vitro, an enhanced chemiluminescence (CI) response and interleukin-1 alpha (IL-1 alpha) production of the macrophages was observed in each instance.	Benzo(a)pyrene	155-169	interleukin 1 alpha	Mus musculus	249-259
7499876-7	1995	BP-specific T cells preincubated in vitro with Gp-BP-SPL were rendered unresponsive to Gp-BP or S72-89, compared with the same T cells preincubated with histone (Hist)-SPL that remained Ag responsive.	Benzo(a)pyrene	0-2	sphingosine-1-phosphate lyase 1	Rattus norvegicus	53-56
7499876-7	1995	BP-specific T cells preincubated in vitro with Gp-BP-SPL were rendered unresponsive to Gp-BP or S72-89, compared with the same T cells preincubated with histone (Hist)-SPL that remained Ag responsive.	Benzo(a)pyrene	0-2	H2B clustered histone 1	Rattus norvegicus	153-160
7499876-7	1995	BP-specific T cells preincubated in vitro with Gp-BP-SPL were rendered unresponsive to Gp-BP or S72-89, compared with the same T cells preincubated with histone (Hist)-SPL that remained Ag responsive.	Benzo(a)pyrene	0-2	H2B clustered histone 1	Rattus norvegicus	162-166
7499876-7	1995	BP-specific T cells preincubated in vitro with Gp-BP-SPL were rendered unresponsive to Gp-BP or S72-89, compared with the same T cells preincubated with histone (Hist)-SPL that remained Ag responsive.	Benzo(a)pyrene	0-2	sphingosine-1-phosphate lyase 1	Rattus norvegicus	168-171
7499876-8	1995	Consistent with an anergy model, preincubation with BP-SPL+IL-2 partially prevented tolerance induction to BP.	Benzo(a)pyrene	52-54	sphingosine-1-phosphate lyase 1	Rattus norvegicus	55-58
21552963-4	1995	DMBA and BP-treated cells gave rise to clones D3, D3-1, BP1 and BP1-E, respectively, all of which expressed colony formation in agar-methocel and high chemoinvasion index.	Benzo(a)pyrene	9-11	BP1	Homo sapiens	56-59
21552963-4	1995	DMBA and BP-treated cells gave rise to clones D3, D3-1, BP1 and BP1-E, respectively, all of which expressed colony formation in agar-methocel and high chemoinvasion index.	Benzo(a)pyrene	9-11	BP1	Homo sapiens	64-67
7488231-0	1995	Modulation by benzo[a]pyrene of epidermal growth factor receptors, cell proliferation, and secretion of human chorionic gonadotropin in human placental cell lines.	Benzo(a)pyrene	14-28	epidermal growth factor	Homo sapiens	32-55
7589580-4	1995	This suggests that PCB-BP/uteroglobin can bind to phospholipids in vivo and may have a role in the phospholipid homeostasis of the airway and/or secretory pathway of the Clara cell.	Benzo(a)pyrene	23-25	secretoglobin family 1A member 1	Homo sapiens	26-37
7488231-2	1995	The present study used human trophoblastic choriocarcinoma cell lines of placental origin to investigate the effects of benz[a]pyrene (BaP) on epidermal growth factor (EGF) receptors, cell proliferation and human chorionic gonadotropin (hCG) secretion.	Benzo(a)pyrene	135-138	epidermal growth factor	Homo sapiens	143-166
7488231-3	1995	BaP decreased 125I-EGF binding and EGF receptor protein in a concentration-related manner in both BeWo and JEG-3 cell lines.	Benzo(a)pyrene	0-3	epidermal growth factor	Homo sapiens	19-22
7488231-3	1995	BaP decreased 125I-EGF binding and EGF receptor protein in a concentration-related manner in both BeWo and JEG-3 cell lines.	Benzo(a)pyrene	0-3	epidermal growth factor	Homo sapiens	35-38
7488231-6	1995	The mitogenic effect of EGF was inhibited by cotreatment with BaP in both cell lines.	Benzo(a)pyrene	62-65	epidermal growth factor	Homo sapiens	24-27
7488231-7	1995	Further study of trophoblast endocrine function showed that both basal and EGF-stimulated secretion of hCG was reduced significantly by BaP exposure in BeWo cells, whereas no adverse effect was seen in JEG-3 cells.	Benzo(a)pyrene	136-139	epidermal growth factor	Homo sapiens	75-78
7488231-8	1995	Finally, cytochrome P450 1A1 (CYP1A1) was induced in a concentration-dependent manner by BaP in both cell lines.	Benzo(a)pyrene	89-92	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	9-28
7488231-8	1995	Finally, cytochrome P450 1A1 (CYP1A1) was induced in a concentration-dependent manner by BaP in both cell lines.	Benzo(a)pyrene	89-92	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
7488231-9	1995	Thus, data indicate that the BaP-mediated loss of EGF receptors alters trophoblast proliferation and endocrine function, and that different mechanisms may be involved in the regulation of hCG secretion in BeWo and JEG-3 cells.	Benzo(a)pyrene	29-32	epidermal growth factor	Homo sapiens	50-53
7666488-7	1995	In rats, benzo[a]pyrene (1 mg/kg, ip) administration daily for 3 d produced a significant increase in liver glutathione S-transferase class mu.	Benzo(a)pyrene	9-23	glutathione S-transferase kappa 1	Homo sapiens	108-133
7574713-10	1995	Collectively, these findings suggest that, in addition to the Ah (dioxin) receptor, glycine N-methyltransferase appears to be both a polycyclic aromatic hydrocarbon-binding protein and a mediator of the induction of the cytochrome P4501A1 gene by polycyclic hydrocarbons such as benzo(a)pyrene.	Benzo(a)pyrene	279-293	glycine N-methyltransferase	Rattus norvegicus	84-111
7574713-10	1995	Collectively, these findings suggest that, in addition to the Ah (dioxin) receptor, glycine N-methyltransferase appears to be both a polycyclic aromatic hydrocarbon-binding protein and a mediator of the induction of the cytochrome P4501A1 gene by polycyclic hydrocarbons such as benzo(a)pyrene.	Benzo(a)pyrene	279-293	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	220-238
7554063-0	1995	p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.	Benzo(a)pyrene	42-56	tumor protein p53	Homo sapiens	0-3
7554063-2	1995	We have measured benzo[a]pyrene (BP)-induced DNA damage in association with p53 expression.	Benzo(a)pyrene	17-31	tumor protein p53	Homo sapiens	76-79
7554063-2	1995	We have measured benzo[a]pyrene (BP)-induced DNA damage in association with p53 expression.	Benzo(a)pyrene	33-35	tumor protein p53	Homo sapiens	76-79
7554063-4	1995	Activation of BP in A-549 lung carcinoma and MCF-7 breast adenocarcinoma cell lines containing wild-type p53 was followed by an increase in p53 protein expression.	Benzo(a)pyrene	14-16	tumor protein p53	Homo sapiens	105-108
7554063-4	1995	Activation of BP in A-549 lung carcinoma and MCF-7 breast adenocarcinoma cell lines containing wild-type p53 was followed by an increase in p53 protein expression.	Benzo(a)pyrene	14-16	tumor protein p53	Homo sapiens	140-143
7554063-8	1995	These findings indicate that p53 protein is part of the response of the cells to BP-induced DNA damage.	Benzo(a)pyrene	81-83	tumor protein p53	Homo sapiens	29-32
7654710-5	1995	Our approach to studying the nature of the bimolecular interface between hormone and receptor is to use a series of specially designed photoreactive benzophenone- (BP-) containing PTH analogs in "photoaffinity scanning" of the PTH/PTHrP receptor.	Benzo(a)pyrene	164-166	parathyroid hormone	Homo sapiens	180-183
7666493-1	1995	Cytochrome P-450 monooxygenases of golden Syrian hamsters were characterized with respect to benzo[a]pyrene metabolism.	Benzo(a)pyrene	93-107	cytochrome P450 2A3-like	Mesocricetus auratus	0-16
7671346-0	1995	Inhibition of benzo[a]pyrene metabolism by insulin, FITC-insulin and an FITC-insulin-antibody conjugate in the human hepatoma cell line HepG2.	Benzo(a)pyrene	14-28	insulin	Homo sapiens	43-50
7671346-3	1995	The human hepatoma cell line, HepG2, was used to examine the effect of inhibition of CYP1A1 activity by anti CYP1A1 specific antibodies on BaP metabolism.	Benzo(a)pyrene	139-142	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-91
7671346-4	1995	Metabolism of BaP to water-soluble metabolites by HepG2 cells in culture was 50% lower in fluorescein isothiocyanate (FITC)-insulin-CYP1A1-antibody-conjugate-treated cells than in control cells.	Benzo(a)pyrene	14-17	insulin	Homo sapiens	124-131
7671346-4	1995	Metabolism of BaP to water-soluble metabolites by HepG2 cells in culture was 50% lower in fluorescein isothiocyanate (FITC)-insulin-CYP1A1-antibody-conjugate-treated cells than in control cells.	Benzo(a)pyrene	14-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
7671346-5	1995	However, FITC-insulin (lacking anti CYP1A1 conjugates) or insulin alone also decreased BaP metabolism by 50%.	Benzo(a)pyrene	87-90	insulin	Homo sapiens	14-21
7671346-5	1995	However, FITC-insulin (lacking anti CYP1A1 conjugates) or insulin alone also decreased BaP metabolism by 50%.	Benzo(a)pyrene	87-90	insulin	Homo sapiens	58-65
7671346-6	1995	This insulin-induced inhibition of BaP metabolism was observed for cultures treated with a concentration range of FITC-insulin from 50-1000 nM.	Benzo(a)pyrene	35-38	insulin	Homo sapiens	5-12
7671346-6	1995	This insulin-induced inhibition of BaP metabolism was observed for cultures treated with a concentration range of FITC-insulin from 50-1000 nM.	Benzo(a)pyrene	35-38	insulin	Homo sapiens	119-126
7671346-8	1995	These results demonstrate that free insulin, FITC-insulin or FITC-insulin conjugated to antibodies are effective inhibitors of BaP metabolism in cells in culture.	Benzo(a)pyrene	127-130	insulin	Homo sapiens	36-43
8572867-7	1995	Without a placebo controlled design, we suggest to increase the BP level for inclusion to determine the % of responders with the standard goal pressure (DBP < 90 mmHg) and to use Oldham"s method for adjusting for the regression to the mean unless the coefficient of correlation found is around zero and if upper level of DBP is not selected for inclusion.	Benzo(a)pyrene	64-66	D-box binding PAR bZIP transcription factor	Homo sapiens	153-156
7587956-7	1995	The enzyme metabolized substrates characteristic for CYP1A1:benzo[a]pyrene (4.0 +/- 0.3 nmol/min/nmol CYP), 7-ethoxy-4-trifluoromethyl- coumarin (36 +/- 2), ethoxyresorufin (37 +/- 1), but not pentoxyresorufin (0.77 +/- 0.02).	Benzo(a)pyrene	60-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
7587963-10	1995	Induction of monkey CYP1A1/2 was associated with a marked increase in the O-dealkylation of 7-methoxyresorufin (up to 65-fold), the O-dealkylation of 7-ethoxyresorufin (up to 30-fold), and the N3-demethylation of caffeine (up to 17-fold), but only a 2-fold increase in benzo[a]pyrene 3-hydroxylation.	Benzo(a)pyrene	269-283	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	20-26
7587963-11	1995	Polyclonal antibodies against CYP1A1 markedly inhibited the N3-demethylation of caffeine and the O-dealkylation of 7-methoxy- and 7-ethoxyresorufin by liver microsomes from beta-naphthoflavone-treated monkeys, and partially inhibited the 3-hydroxylation of benzo[a]pyrene, indicating that monkey CYP1A1 and/or CYP1A2, like the corresponding rat enzymes, can catalyze all four reactions.	Benzo(a)pyrene	257-271	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	30-36
21552801-2	1995	The treatment of MCF 10F with BP gave rise to different clones designated BP1 and BP1E, the latter being a tumorigenic cell line.	Benzo(a)pyrene	30-32	BP1	Homo sapiens	74-77
7562894-2	1995	This is true across a broad range of BP levels, including those considered "normal"; more than half of all cardiovascular events attributed to raised BP occur when DBP is < or = 95 mmHg.	Benzo(a)pyrene	37-39	D-box binding PAR bZIP transcription factor	Homo sapiens	164-167
7562894-2	1995	This is true across a broad range of BP levels, including those considered "normal"; more than half of all cardiovascular events attributed to raised BP occur when DBP is < or = 95 mmHg.	Benzo(a)pyrene	150-152	D-box binding PAR bZIP transcription factor	Homo sapiens	164-167
7483671-10	1995	These results confirm the localization of charge in the BP.+ at C-6, followed by C-1 and C-3.	Benzo(a)pyrene	56-58	complement C6	Homo sapiens	64-67
7483671-10	1995	These results confirm the localization of charge in the BP.+ at C-6, followed by C-1 and C-3.	Benzo(a)pyrene	56-58	complement C3	Homo sapiens	89-92
7654710-5	1995	Our approach to studying the nature of the bimolecular interface between hormone and receptor is to use a series of specially designed photoreactive benzophenone- (BP-) containing PTH analogs in "photoaffinity scanning" of the PTH/PTHrP receptor.	Benzo(a)pyrene	164-166	parathyroid hormone 1 receptor	Homo sapiens	227-245
7654710-11	1995	Analysis of photo-cross-linked conjugates of PTH/PTHrP receptor with BP-containing PTH analogs should help to identify the "contact points" between ligand and receptor.	Benzo(a)pyrene	69-71	parathyroid hormone 1 receptor	Homo sapiens	45-63
7654710-11	1995	Analysis of photo-cross-linked conjugates of PTH/PTHrP receptor with BP-containing PTH analogs should help to identify the "contact points" between ligand and receptor.	Benzo(a)pyrene	69-71	parathyroid hormone	Homo sapiens	45-48
7663513-2	1995	We have studied the effects of the environmental teratogen, benzo[a]pyrene, on pregnant heterozygous p53-deficient mice.	Benzo(a)pyrene	60-74	transformation related protein 53, pseudogene	Mus musculus	101-104
7766306-6	1995	The other two benzo[a]pyrene-induced base-pair changes in codon 248, namely the C-to-A transversion in the first position and G-to-T transversion in the third position, do not lead to a change in the amino-acid composition of the p53 protein.	Benzo(a)pyrene	14-28	tumor protein p53	Homo sapiens	230-233
7767909-9	1995	DR increased benzo[a]pyrene (BaP) metabolic activation in both young and aged rats.	Benzo(a)pyrene	13-27	prohibitin 2	Rattus norvegicus	29-32
21556625-3	1995	DMBA-treated cells gave rise to clones D3 and D3-1, BP-treated cells gave rise to clones BP1 and BP1-E. BP1-E cell line, derived from BP1 cell line, was tumorigenic in SCID mice.	Benzo(a)pyrene	52-54	BP1	Homo sapiens	89-92
21556625-3	1995	DMBA-treated cells gave rise to clones D3 and D3-1, BP-treated cells gave rise to clones BP1 and BP1-E. BP1-E cell line, derived from BP1 cell line, was tumorigenic in SCID mice.	Benzo(a)pyrene	52-54	BP1	Homo sapiens	97-100
21556625-3	1995	DMBA-treated cells gave rise to clones D3 and D3-1, BP-treated cells gave rise to clones BP1 and BP1-E. BP1-E cell line, derived from BP1 cell line, was tumorigenic in SCID mice.	Benzo(a)pyrene	52-54	BP1	Homo sapiens	97-100
21556625-3	1995	DMBA-treated cells gave rise to clones D3 and D3-1, BP-treated cells gave rise to clones BP1 and BP1-E. BP1-E cell line, derived from BP1 cell line, was tumorigenic in SCID mice.	Benzo(a)pyrene	52-54	BP1	Homo sapiens	97-100
7766306-8	1995	It follows that benzo[a]pyrene-induced mutability on the DNA level in p53 codons 247-250 correlates well with the type of mutation found in tumors of the lung.	Benzo(a)pyrene	16-30	tumor protein p53	Homo sapiens	70-73
7595905-9	1995	Its peak BP effect appears to be at the dosing interval corresponding to pharmacological blockade of angiotensin II receptors.	Benzo(a)pyrene	9-11	angiotensinogen	Homo sapiens	101-115
7603785-8	1995	These results indicate, for the first time, that neonatal BaP exposure results in gender-specific lasting effects on hepatic cytochrome P450 1A2, cytochrome P450 2C11, and glucocorticoid receptors in adult male rats, whereas these parameters are unchanged in adult female rats.	Benzo(a)pyrene	58-61	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	125-144
7603785-8	1995	These results indicate, for the first time, that neonatal BaP exposure results in gender-specific lasting effects on hepatic cytochrome P450 1A2, cytochrome P450 2C11, and glucocorticoid receptors in adult male rats, whereas these parameters are unchanged in adult female rats.	Benzo(a)pyrene	58-61	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	146-166
7726552-6	1995	Exposure of quiescent SMCs to 30 microM BaP inhibited the ability of serum to induce c-fos mRNA expression and decreased AP-1 binding to a 12-O-tetradecanoyl phorbol-13-acetate responsive element.	Benzo(a)pyrene	40-43	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-90
7726552-7	1995	Inhibition of PKC-related signal transduction was not due to generalized interference with cell cycle events since peak expression of the c-myc and c-Ha-ras protooncogenes following serum stimulation of quiescent cultures was unchanged, or slightly enhanced, by 30 microM BaP.	Benzo(a)pyrene	272-275	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	138-143
7882364-0	1995	Characterization of hprt splicing mutations induced by the ultimate carcinogenic metabolite of benzo[a]pyrene in Chinese hamster V-79 cells.	Benzo(a)pyrene	95-109	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	20-24
7591186-2	1995	Because CYP1A1 catalyzes bioactivation of environmental procarcinogens, such as benzo[a]pyrene, it is very important to study the clinical meaning of Ile-Val polymorphism using an epidemiological study.	Benzo(a)pyrene	80-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	8-14
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Benzo(a)pyrene	87-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Benzo(a)pyrene	87-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7880810-4	1995	This BP-11-mer duplex exhibits NOESY cross-peaks between benzo[a]pyrene protons and BP-G8, C9, A16, and C17 nucleotide protons that clearly delineate the location of the BP moiety in the minor groove of a B-type duplex with the pyrene ring oriented toward the 5" end of the modified strand.	Benzo(a)pyrene	5-7	cytokine like 1	Homo sapiens	104-107
7880810-4	1995	This BP-11-mer duplex exhibits NOESY cross-peaks between benzo[a]pyrene protons and BP-G8, C9, A16, and C17 nucleotide protons that clearly delineate the location of the BP moiety in the minor groove of a B-type duplex with the pyrene ring oriented toward the 5" end of the modified strand.	Benzo(a)pyrene	57-71	cytokine like 1	Homo sapiens	104-107
7866987-0	1995	Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.	Benzo(a)pyrene	120-134	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	34-61
7859347-0	1995	Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin.	Benzo(a)pyrene	33-47	CD1 antigen complex	Mus musculus	58-62
7556107-15	1995	The cytogenetic data are consistent, first-off, with reports that individuals in the population vary widely with respect to the inducibility of the CYP1A1 gene, which is known to be involved in polycyclic aromatic hydrocarbon metabolism, in particular, in BaP.	Benzo(a)pyrene	256-259	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	148-154
7581497-2	1995	Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene.	Benzo(a)pyrene	196-210	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
7581497-2	1995	Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene.	Benzo(a)pyrene	196-210	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
7581497-6	1995	Most important was the finding, that human cytochrome P450 1A1 almost exclusively oxidized benzo[a]pyrene in the 7,8,9,10-position, yielding the ultimate carcinogen 7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene whereas the rat cytochrome P450 1A1 oxidized benzo[]pyrene in the 4,5-position and 7,8,9,10-position.	Benzo(a)pyrene	91-105	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-62
7581497-6	1995	Most important was the finding, that human cytochrome P450 1A1 almost exclusively oxidized benzo[a]pyrene in the 7,8,9,10-position, yielding the ultimate carcinogen 7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene whereas the rat cytochrome P450 1A1 oxidized benzo[]pyrene in the 4,5-position and 7,8,9,10-position.	Benzo(a)pyrene	91-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	241-260
7581497-8	1995	Benzo[a]pyrene was twice as cytotoxic in the human cytochrome P450 1A1 than in the rat cytochrome P450 1A1 expressing V79 cells.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-70
7581497-8	1995	Benzo[a]pyrene was twice as cytotoxic in the human cytochrome P450 1A1 than in the rat cytochrome P450 1A1 expressing V79 cells.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	87-106
8524738-4	1995	For contents of benz(a)pyrene and mineral oils exceeding 2.5 to 3.5 times the respective occupational environment MACs, evidence from cytogenetic analysis showed substantial, 4-fold, increase in indexes of genotoxic impairment (frequency of micronucleated-binucleated lymphocytes, number of micronuclei per 1000 binucleated lymphocytes) in the workers investigated.	Benzo(a)pyrene	16-29	myristoylated alanine rich protein kinase C substrate	Homo sapiens	114-118
8001254-1	1994	Carcinogen-DNA adducts and somatic gene mutation at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus were evaluated in peripheral leukocytes of workers in an iron foundry with exposure to benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons (PAHs).	Benzo(a)pyrene	204-218	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	56-103
8001254-1	1994	Carcinogen-DNA adducts and somatic gene mutation at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus were evaluated in peripheral leukocytes of workers in an iron foundry with exposure to benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons (PAHs).	Benzo(a)pyrene	204-218	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	105-109
7989468-12	1994	However, it cannot be excluded that the milk BP may represent a proteolytically or otherwise altered truncated form of the PRL receptor (or, less likely, the GH receptor) that maintains some binding activity, but has its immunological epitope(s) disabled.	Benzo(a)pyrene	45-47	prolactin receptor	Homo sapiens	123-135
7526191-3	1994	The efficient reversion of the trpA23 allele by G.C-T.A transversions in benzo[a]pyrene (B[a]P)-treated cells required the function of a matured MucA protein.	Benzo(a)pyrene	73-87	MucA	Escherichia coli	145-149
7526191-3	1994	The efficient reversion of the trpA23 allele by G.C-T.A transversions in benzo[a]pyrene (B[a]P)-treated cells required the function of a matured MucA protein.	Benzo(a)pyrene	89-94	MucA	Escherichia coli	145-149
7989468-12	1994	However, it cannot be excluded that the milk BP may represent a proteolytically or otherwise altered truncated form of the PRL receptor (or, less likely, the GH receptor) that maintains some binding activity, but has its immunological epitope(s) disabled.	Benzo(a)pyrene	45-47	growth hormone receptor	Homo sapiens	158-169
20693087-6	1994	It is suggested that vitamin C is directly bound to the substrate BP, to cytochrome P-450 itself or to the substrate-enzyme complex, thus lowering the rate of AHH reaction, and that the mechanisms of inhibition of AHH and suppression of mutagenicity by vitamin C are different from those of PCB metabolites.	Benzo(a)pyrene	66-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	159-162
7696539-6	1994	This previously unrealized enantiospecificity of the reaction of benzo[a]pyrene anti-diol epoxide with human serum albumin has important consequences for the application of the adducts as biomarkers of internal exposure.	Benzo(a)pyrene	65-79	albumin	Homo sapiens	109-122
8051410-6	1994	The first element is a remote kappa B binding site located far upstream between bp -2612 and -2603 that was important for IL-1 beta-, TNF-alpha-, and 2-O-tetradecanoylphorbol 13-acetate-induced enhancer activity.	Benzo(a)pyrene	80-82	interleukin 1 beta	Homo sapiens	122-131
7923575-1	1994	Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP).	Benzo(a)pyrene	149-163	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
7923575-1	1994	Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP).	Benzo(a)pyrene	149-163	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
7923575-1	1994	Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP).	Benzo(a)pyrene	165-167	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
7923575-1	1994	Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP).	Benzo(a)pyrene	165-167	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
7923575-2	1994	In non-hepatic human tissues, CYP1A1 is the principal enzyme responsible for the metabolic activation of the proximate BP mutagenic metabolite, (-)-benzo[a]pyrene-trans-7,8-dihydrodiol, to (+)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide, the ultimate BP mutagen.	Benzo(a)pyrene	119-121	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
7923575-2	1994	In non-hepatic human tissues, CYP1A1 is the principal enzyme responsible for the metabolic activation of the proximate BP mutagenic metabolite, (-)-benzo[a]pyrene-trans-7,8-dihydrodiol, to (+)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide, the ultimate BP mutagen.	Benzo(a)pyrene	262-264	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
8051410-6	1994	The first element is a remote kappa B binding site located far upstream between bp -2612 and -2603 that was important for IL-1 beta-, TNF-alpha-, and 2-O-tetradecanoylphorbol 13-acetate-induced enhancer activity.	Benzo(a)pyrene	80-82	tumor necrosis factor	Homo sapiens	134-143
8055640-0	1994	Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.	Benzo(a)pyrene	94-108	transformation related protein 53, pseudogene	Mus musculus	132-135
8055656-1	1994	Earlier studies from our laboratories characterized the mutation profile of the optically active (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-BPDE--the ultimate carcinogenic metabolite of benzo[a]pyrene] in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells.	Benzo(a)pyrene	149-163	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	259-307
8055656-1	1994	Earlier studies from our laboratories characterized the mutation profile of the optically active (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-BPDE--the ultimate carcinogenic metabolite of benzo[a]pyrene] in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells.	Benzo(a)pyrene	149-163	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	309-313
8036011-7	1994	It is evident that H2O2/FeCl3 possesses essentially the same mutagenic specificity for codons 249 and 250 of p53 as bulky carcinogens such as aflatoxin B1, benzo(a)pyrene or heterocyclic amines.	Benzo(a)pyrene	156-170	tumor protein p53	Homo sapiens	109-112
8021962-4	1994	Flow cytometric analysis indicated that the BaP treatment resulted in a significant decrease in the percentage of CD4+8+ fetal thymocytes, as well as significantly increased CD4-8- and CD4-8+ thymocytes.	Benzo(a)pyrene	44-47	CD4 antigen	Mus musculus	114-117
8048075-3	1994	We have shown previously in vivo and in hepatic microsomes that rats with a hereditary deficiency in bilirubin UGT (Gunn and RHA strains) have decreased glucuronidation of BP metabolites and enhanced BP covalent binding to hepatic DNA and microsomal protein, and enhanced BP embryotoxicity.	Benzo(a)pyrene	172-174	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	111-114
8048075-3	1994	We have shown previously in vivo and in hepatic microsomes that rats with a hereditary deficiency in bilirubin UGT (Gunn and RHA strains) have decreased glucuronidation of BP metabolites and enhanced BP covalent binding to hepatic DNA and microsomal protein, and enhanced BP embryotoxicity.	Benzo(a)pyrene	200-202	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	111-114
8048075-4	1994	We further hypothesized that a similar deficiency in BP glucuronidation, with increased BP bioactivation and covalent binding, might be observed in peripheral blood lymphocytes from UGT-deficient rats, which, if true, would suggest the utility of an analogous human lymphocyte model for evaluating the toxicological relevance of human UGT deficiencies.	Benzo(a)pyrene	53-55	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	182-185
8048075-4	1994	We further hypothesized that a similar deficiency in BP glucuronidation, with increased BP bioactivation and covalent binding, might be observed in peripheral blood lymphocytes from UGT-deficient rats, which, if true, would suggest the utility of an analogous human lymphocyte model for evaluating the toxicological relevance of human UGT deficiencies.	Benzo(a)pyrene	88-90	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	182-185
8048075-11	1994	Reduced BP glucuronidation in lymphocytes from UGT-deficient RHA rats correlated with elevated BP covalent binding (R2 = 0.85, p < 0.005).	Benzo(a)pyrene	8-10	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	47-50
8048075-13	1994	These results in UGT-deficient lymphocytes also accurately reflected the in vivo biotransformation and covalent binding of BP in UGT-deficient rats.	Benzo(a)pyrene	123-125	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	17-20
8048075-13	1994	These results in UGT-deficient lymphocytes also accurately reflected the in vivo biotransformation and covalent binding of BP in UGT-deficient rats.	Benzo(a)pyrene	123-125	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	129-132
8021962-4	1994	Flow cytometric analysis indicated that the BaP treatment resulted in a significant decrease in the percentage of CD4+8+ fetal thymocytes, as well as significantly increased CD4-8- and CD4-8+ thymocytes.	Benzo(a)pyrene	44-47	CD4 antigen	Mus musculus	174-177
8021962-4	1994	Flow cytometric analysis indicated that the BaP treatment resulted in a significant decrease in the percentage of CD4+8+ fetal thymocytes, as well as significantly increased CD4-8- and CD4-8+ thymocytes.	Benzo(a)pyrene	44-47	CD4 antigen	Mus musculus	174-177
8021962-8	1994	In particular, prolymphocytic cells, identified by CD44 and CD45R antigen expression and by presence of nuclear terminal deoxynucleotidyl transferase (TdT), were significantly decreased in animals gestationally exposed to BaP.	Benzo(a)pyrene	222-225	CD44 antigen	Mus musculus	51-55
8021962-8	1994	In particular, prolymphocytic cells, identified by CD44 and CD45R antigen expression and by presence of nuclear terminal deoxynucleotidyl transferase (TdT), were significantly decreased in animals gestationally exposed to BaP.	Benzo(a)pyrene	222-225	protein tyrosine phosphatase, receptor type, C	Mus musculus	60-65
8021962-8	1994	In particular, prolymphocytic cells, identified by CD44 and CD45R antigen expression and by presence of nuclear terminal deoxynucleotidyl transferase (TdT), were significantly decreased in animals gestationally exposed to BaP.	Benzo(a)pyrene	222-225	deoxynucleotidyltransferase, terminal	Mus musculus	112-149
8021962-8	1994	In particular, prolymphocytic cells, identified by CD44 and CD45R antigen expression and by presence of nuclear terminal deoxynucleotidyl transferase (TdT), were significantly decreased in animals gestationally exposed to BaP.	Benzo(a)pyrene	222-225	deoxynucleotidyltransferase, terminal	Mus musculus	151-154
8075628-1	1994	The micronucleus test (MNT) was applied in the epithelial cells from the bladder of mice treated with benzo(a)pyrene (BaP), 2-acetylaminofluorene (2-AAF) and cyclophosphamide (CP).	Benzo(a)pyrene	102-116	prohibitin 2	Mus musculus	118-121
8010956-3	1994	Treatment of these fibroblasts with 0.5 microgram/ml 7,12-dimethyl-benz[a]anthracene or benzo[a]pyrene for 24 h greatly decreased (> 80%) the amount of immunoreactive PKC-epsilon.	Benzo(a)pyrene	88-102	protein kinase C, epsilon	Mus musculus	170-181
7937598-0	1994	Modifications of glutathione S-transferase (GST) activity in the last period of pregnancy in rats treated with benzo(a)pyrene (BP).	Benzo(a)pyrene	111-125	hematopoietic prostaglandin D synthase	Rattus norvegicus	17-42
7937598-0	1994	Modifications of glutathione S-transferase (GST) activity in the last period of pregnancy in rats treated with benzo(a)pyrene (BP).	Benzo(a)pyrene	111-125	hematopoietic prostaglandin D synthase	Rattus norvegicus	44-47
7937598-0	1994	Modifications of glutathione S-transferase (GST) activity in the last period of pregnancy in rats treated with benzo(a)pyrene (BP).	Benzo(a)pyrene	127-129	hematopoietic prostaglandin D synthase	Rattus norvegicus	17-42
7937598-0	1994	Modifications of glutathione S-transferase (GST) activity in the last period of pregnancy in rats treated with benzo(a)pyrene (BP).	Benzo(a)pyrene	127-129	hematopoietic prostaglandin D synthase	Rattus norvegicus	44-47
7937598-7	1994	These results suggest that BP, initially, stimulates GST synthesis in placenta, followed by an inhibition of the enzyme at day 19.	Benzo(a)pyrene	27-29	hematopoietic prostaglandin D synthase	Rattus norvegicus	53-56
7515181-2	1994	It has been previously demonstrated that Cop 1 is immunologically cross-reactive with the autoantigen myelin basic protein (BP) and competitively inhibits the response to BP of T-cell lines and clones of different major histocompatibility complex (MHC) restrictions, of both mouse and human origin.	Benzo(a)pyrene	124-126	myelin basic protein	Mus musculus	102-122
7909358-2	1994	Using altered DNA specificity Bicoid mutants and appropriate reporter genes, we show that Bicoid distinguishes among related DNA-binding sites in vivo by a specific contact between amino acid 9 of its recognition alpha-helix (lysine 50 of the homeodomain) and bp 7 of the site.	Benzo(a)pyrene	260-262	bicoid	Drosophila melanogaster	90-96
8200084-7	1994	In contrast, benzo[a]pyrene was exclusively activated by CYP1A1 whereas CYP1A2 was inactive.	Benzo(a)pyrene	13-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-63
8160212-0	1994	Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene.	Benzo(a)pyrene	130-144	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40
8160212-1	1994	The present studies were undertaken to provide a rationale for the observation that benzo(a)pyrene and 2-acetylaminofluorene induce the hepatic CYP1A1 protein, whereas their non-carcinogenic isomers benzo(e)pyrene and 4-acetylaminofluorene are, at best, relatively very weak inducers.	Benzo(a)pyrene	84-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	144-150
8163517-1	1994	The aromatic hydrocarbon (Ah) receptor is a cytosolic protein that binds halogenated ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and nonhalogenated ligands such as 3-methylcholanthrene (MC) and benzo[a]pyrene.	Benzo(a)pyrene	209-223	aryl hydrocarbon receptor	Homo sapiens	4-38
8021906-9	1994	We conclude that reduction of BP with endurance exercise training in these mildly hypertensive men was primarily associated with reduced plasma renin activity and did not adversely affect quality of life.	Benzo(a)pyrene	30-32	renin	Homo sapiens	144-149
8090695-3	1994	Pretreatment with murine interferon-alpha/beta (5 x 10(4) IU daily for two days) caused a significative decrease in the cytogenetic response in vivo of benzo(a)pyrene (up to 51%) and a stabilization of aberrant cells up to 48 hr.	Benzo(a)pyrene	152-166	interferon alpha	Mus musculus	25-41
8313504-7	1994	However, BHK21-mEH/Mz1 cell homogenates were found to catalyze the conjugation of B[a]P 4,5-oxide to glutathione extremely well.	Benzo(a)pyrene	82-87	epoxide hydrolase 1, microsomal	Mus musculus	15-18
7912124-2	1994	Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1.	Benzo(a)pyrene	96-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
7912124-2	1994	Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1.	Benzo(a)pyrene	96-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
7912124-2	1994	Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1.	Benzo(a)pyrene	96-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-146
7512148-3	1994	Expansion of "activated" CSF cells with IL-2/IL-4 plus accessory cells optimally retained BP-responsive T cells that over-expressed V beta 1, V beta 2, V beta 5, or V beta 18, compared to expansion using supernatants from PHA-stimulated blood cells, or anti-CD3 antibody that led to different V gene bias and rare reactivity to BP.	Benzo(a)pyrene	90-92	interleukin 2	Homo sapiens	40-44
7512148-3	1994	Expansion of "activated" CSF cells with IL-2/IL-4 plus accessory cells optimally retained BP-responsive T cells that over-expressed V beta 1, V beta 2, V beta 5, or V beta 18, compared to expansion using supernatants from PHA-stimulated blood cells, or anti-CD3 antibody that led to different V gene bias and rare reactivity to BP.	Benzo(a)pyrene	90-92	interleukin 4	Homo sapiens	45-49
7512148-3	1994	Expansion of "activated" CSF cells with IL-2/IL-4 plus accessory cells optimally retained BP-responsive T cells that over-expressed V beta 1, V beta 2, V beta 5, or V beta 18, compared to expansion using supernatants from PHA-stimulated blood cells, or anti-CD3 antibody that led to different V gene bias and rare reactivity to BP.	Benzo(a)pyrene	90-92	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	134-160
7512148-3	1994	Expansion of "activated" CSF cells with IL-2/IL-4 plus accessory cells optimally retained BP-responsive T cells that over-expressed V beta 1, V beta 2, V beta 5, or V beta 18, compared to expansion using supernatants from PHA-stimulated blood cells, or anti-CD3 antibody that led to different V gene bias and rare reactivity to BP.	Benzo(a)pyrene	328-330	interleukin 2	Homo sapiens	40-44
7512148-7	1994	These data indicate that selective expansion of IL-2/IL-4-responsive CSF cells favors growth of the BP-reactive subpopulation, and, in a limited number of patients studied, reflected clinical disease activity.	Benzo(a)pyrene	100-102	interleukin 2	Homo sapiens	48-52
7512148-7	1994	These data indicate that selective expansion of IL-2/IL-4-responsive CSF cells favors growth of the BP-reactive subpopulation, and, in a limited number of patients studied, reflected clinical disease activity.	Benzo(a)pyrene	100-102	interleukin 4	Homo sapiens	53-57
8126925-7	1994	Since AHH is also responsible for the activation to carcinogens of benzo (a)pyrene and other aromatic hydrocarbons in cigarette smoke, it may also be important in humans in the causation of lung cancer.	Benzo(a)pyrene	67-82	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-9
12369593-4	1994	Nevertheless, DMBA induces a specific isozyme of cytochrome P-450 1A1 since, for an equal dose administered to C57BL/6 mice (200 mg/kg body weight), the DMBA-hydroxylase activity was 1.72-fold increased by DMBA while it remained unchanged after BP treatment.	Benzo(a)pyrene	245-247	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-69
8013474-2	1994	Reversion of the hisD3052 frameshift mutation by benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1) and 1-nitropyrene (1-NP), was very efficiently promoted by UmuD" (the activated form of UmuD) and UmuC proteins.	Benzo(a)pyrene	49-63	UmuD	Escherichia coli	152-157
8013474-2	1994	Reversion of the hisD3052 frameshift mutation by benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1) and 1-nitropyrene (1-NP), was very efficiently promoted by UmuD" (the activated form of UmuD) and UmuC proteins.	Benzo(a)pyrene	49-63	UmuD	Escherichia coli	152-156
8013474-2	1994	Reversion of the hisD3052 frameshift mutation by benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1) and 1-nitropyrene (1-NP), was very efficiently promoted by UmuD" (the activated form of UmuD) and UmuC proteins.	Benzo(a)pyrene	65-70	UmuD	Escherichia coli	152-157
8013474-2	1994	Reversion of the hisD3052 frameshift mutation by benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1) and 1-nitropyrene (1-NP), was very efficiently promoted by UmuD" (the activated form of UmuD) and UmuC proteins.	Benzo(a)pyrene	65-70	UmuD	Escherichia coli	152-156
8269638-0	1993	The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases.	Benzo(a)pyrene	51-65	beta-1,3-glucuronyltransferase 2	Homo sapiens	116-144
7935989-1	1994	The copper content and ceruloplasmin activity were determined in mice bearing benzo(a)pyrene induced fibrosarcoma.	Benzo(a)pyrene	78-92	ceruloplasmin	Mus musculus	23-36
7903198-2	1993	We previously showed that MDR cells derived from exposure to Adriamycin are cross-resistant to a chemical carcinogen, benzo(a)pyrene, due to its cellular efflux by the P-gp-mediated putative drug efflux pump.	Benzo(a)pyrene	118-132	ATP binding cassette subfamily B member 1	Homo sapiens	168-172
8269638-1	1993	The capacity of four cDNA-expressed human liver UDP-glucuronosyltransferases (UGT), UGT1*6, UGT2B7, UGT2B10 and UGT2B11, to glucuronidate hydroxylated metabolites of benzo[a]pyrene (B[a]P) and 2-acetylaminofluorene (AAF) has been investigated.	Benzo(a)pyrene	166-180	beta-1,3-glucuronyltransferase 2	Homo sapiens	48-76
8269638-1	1993	The capacity of four cDNA-expressed human liver UDP-glucuronosyltransferases (UGT), UGT1*6, UGT2B7, UGT2B10 and UGT2B11, to glucuronidate hydroxylated metabolites of benzo[a]pyrene (B[a]P) and 2-acetylaminofluorene (AAF) has been investigated.	Benzo(a)pyrene	166-180	beta-1,3-glucuronyltransferase 2	Homo sapiens	78-81
8269638-1	1993	The capacity of four cDNA-expressed human liver UDP-glucuronosyltransferases (UGT), UGT1*6, UGT2B7, UGT2B10 and UGT2B11, to glucuronidate hydroxylated metabolites of benzo[a]pyrene (B[a]P) and 2-acetylaminofluorene (AAF) has been investigated.	Benzo(a)pyrene	166-180	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	84-90
8269638-1	1993	The capacity of four cDNA-expressed human liver UDP-glucuronosyltransferases (UGT), UGT1*6, UGT2B7, UGT2B10 and UGT2B11, to glucuronidate hydroxylated metabolites of benzo[a]pyrene (B[a]P) and 2-acetylaminofluorene (AAF) has been investigated.	Benzo(a)pyrene	166-180	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	100-107
8269638-1	1993	The capacity of four cDNA-expressed human liver UDP-glucuronosyltransferases (UGT), UGT1*6, UGT2B7, UGT2B10 and UGT2B11, to glucuronidate hydroxylated metabolites of benzo[a]pyrene (B[a]P) and 2-acetylaminofluorene (AAF) has been investigated.	Benzo(a)pyrene	166-180	UDP glucuronosyltransferase family 2 member B11	Homo sapiens	112-119
8148869-5	1993	Surprisingly, in contrast to the rat gene that is expressed in both cell cultures and the intact liver, the murine Ahd-4 gene is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) or benzo[a]pyrene in cell cultures but not in liver of the intact adult or newborn mouse.	Benzo(a)pyrene	196-210	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	115-120
8148869-8	1993	Our data suggest that the Ahd-4 gene in murine cell cultures is regulated by three distinct mechanisms: Ah receptor-mediated induction by TCDD or benzo[a]pyrene, CYP1A1 metabolism-dependent repression, and Chr 7-mediated putative derepression.	Benzo(a)pyrene	146-160	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	26-31
8148869-8	1993	Our data suggest that the Ahd-4 gene in murine cell cultures is regulated by three distinct mechanisms: Ah receptor-mediated induction by TCDD or benzo[a]pyrene, CYP1A1 metabolism-dependent repression, and Chr 7-mediated putative derepression.	Benzo(a)pyrene	146-160	aryl-hydrocarbon receptor	Mus musculus	104-115
8242857-0	1993	Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.	Benzo(a)pyrene	20-34	Harvey rat sarcoma virus oncogene	Mus musculus	71-77
8242857-1	1993	The frequency and spectrum of Ha-ras mutations in benzo[a]pyrene (B[a]P)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted CD-1 mouse skin papillomas were characterized by amplifying high molecular weight papilloma DNA using the polymerase chain reaction (PCR) followed by direct DNA sequencing.	Benzo(a)pyrene	50-64	Harvey rat sarcoma virus oncogene	Mus musculus	30-36
8242857-1	1993	The frequency and spectrum of Ha-ras mutations in benzo[a]pyrene (B[a]P)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted CD-1 mouse skin papillomas were characterized by amplifying high molecular weight papilloma DNA using the polymerase chain reaction (PCR) followed by direct DNA sequencing.	Benzo(a)pyrene	66-71	Harvey rat sarcoma virus oncogene	Mus musculus	30-36
8236254-4	1993	BP treatment increased mRNA of CYP2B1, 2B2, 2C6, 2C11, and 3A1 in control and surrounding tissue substantially, but was 3 to 11 times less in the nodules than in the control liver.	Benzo(a)pyrene	0-2	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	31-37
8222045-3	1993	Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor.	Benzo(a)pyrene	52-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	163-169
8222045-3	1993	Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor.	Benzo(a)pyrene	52-66	aryl hydrocarbon receptor	Homo sapiens	230-241
8293790-0	1993	Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.	Benzo(a)pyrene	109-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	27-46
8292743-3	1993	Because 3-hydroxybenzo[a]-pyrene is one of the major metabolites of BP, preparation of 3-fluorobenzo[a]pyrene (3-FBP) was undertaken.	Benzo(a)pyrene	68-70	ECB2	Homo sapiens	113-116
7689475-1	1993	We demonstrate that blockage of EGF receptor signal transduction is sufficient by itself to cause a rapid, efficient, and reversible G0-like growth arrest of normal human mammary epithelial cells (HMEC) of finite lifespan as well as two immortally transformed cell lines derived from normal HMEC following in vitro transformation with benzo[a]pyrene.	Benzo(a)pyrene	335-349	epidermal growth factor receptor	Homo sapiens	32-44
8227480-8	1993	Due to the fact that the minimal effective dose was used in this trial, further studies with higher doses should demonstrate effective 24-hour control of BP as described with other long-acting ACE inhibitors.	Benzo(a)pyrene	154-156	angiotensin I converting enzyme	Homo sapiens	193-196
8402586-2	1993	The present communication compares the rate of DNA adduct formation in human lymphocytes incubated for varying times with different concentrations of benzo(a)pyrene (B(A)P).	Benzo(a)pyrene	150-164	prohibitin 2	Homo sapiens	166-171
8507205-0	1993	The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen.	Benzo(a)pyrene	72-86	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	47-62
8353849-2	1993	In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents.	Benzo(a)pyrene	114-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	15-34
8353849-2	1993	In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents.	Benzo(a)pyrene	114-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42
8353849-12	1993	These studies demonstrate the usefulness of the CYP1A1 transformed fibroblasts in examining the cytotoxic effects of benzo[a]pyrene metabolites and suggest the future usefulness in examining the toxic effects of polycyclic aromatic hydrocarbons and other xenobiotics bioactivated by CYP1A1.	Benzo(a)pyrene	117-131	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
8230085-4	1993	Selective AT1 receptor blockade with losartan lowers BP in angiotensin II-dependent models of hypertension, reduces cardiac hypertrophy, improves haemodynamics in models of cardiac failure and reduces the intimal response to vascular injury.	Benzo(a)pyrene	53-55	angiotensin II receptor, type 1a	Rattus norvegicus	10-13
8230085-4	1993	Selective AT1 receptor blockade with losartan lowers BP in angiotensin II-dependent models of hypertension, reduces cardiac hypertrophy, improves haemodynamics in models of cardiac failure and reduces the intimal response to vascular injury.	Benzo(a)pyrene	53-55	angiotensinogen	Rattus norvegicus	59-73
8246314-0	1993	High susceptibility to aflatoxin B1 and benzo[a]pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1.	Benzo(a)pyrene	40-54	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	98-104
8246314-1	1993	The monkey CYP1A1 has been expressed in BALB 3T3 A31-1-1 cells and the expressed proteins were assayed for their capacity to activate aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P).	Benzo(a)pyrene	158-172	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	11-17
8374053-2	1993	Substitution of BP at C-6 with fluorine to form 6-fluorobenzo[a]pyrene (6-FBP) or a methyl group to form 6-methylbenzo[a]pyrene (6-CH3BP) decreases tumorigenicity compared to BP.	Benzo(a)pyrene	16-18	far upstream element binding protein 1	Rattus norvegicus	74-77
8374053-3	1993	BP, 6-FBP, and 6-CH3BP formed adducts with DNA when (1) they were activated by 3-methylcholanthrene-induced rat liver microsomes, (2) they were activated by horseradish peroxidase (HRP), (3) their 7,8-dihydrodiols were activated by microsomes, or (4) the radical cation of BP, 6-FBP, or 6-CH3-BP was directly reacted with DNA.	Benzo(a)pyrene	0-2	far upstream element binding protein 1	Rattus norvegicus	279-282
8395783-4	1993	The original observations about genetic differences in CYP1A1 (cytochrome P1-450) induction by TCDD or benzo[a]pyrene in the mouse have led to an appreciation for a similar polymorphism in the human and the recent cloning of the murine Ah receptor (Ahr) and human Ah receptor nuclear translocator (ARNT) genes.	Benzo(a)pyrene	103-117	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	55-61
8508499-2	1993	In order to establish the mechanisms by which such compounds may elicit a protective effect at DNA level, the influence of these compounds upon benzo[a]pyrene (BaP) activation by 3-methyl-cholanthrene-stimulated microsomes was also studied.	Benzo(a)pyrene	144-158	prohibitin 2	Homo sapiens	160-163
8504760-7	1993	PRL BP was purified from estradiol-treated ovariectomized females by an oPRL sepharose 4B affinity column.	Benzo(a)pyrene	4-6	prolactin	Rattus norvegicus	0-3
8332081-1	1993	The metabolic capacity to activate the indirectly acting promutagens aflatoxin B1, cyclophosphamide, benzo[a]-pyrene, 7,12-dimethylbenz[a]anthracene and dimethylnitrosamine into DNA-reactive metabolites was investigated in three immortalized rat hepatocyte cell lines (NRL cl-B, NRL cl-C and ARL) by analysing chromosome aberrations and sister chromatid exchange (SCE).	Benzo(a)pyrene	101-116	neural retina leucine zipper	Rattus norvegicus	269-272
8332081-1	1993	The metabolic capacity to activate the indirectly acting promutagens aflatoxin B1, cyclophosphamide, benzo[a]-pyrene, 7,12-dimethylbenz[a]anthracene and dimethylnitrosamine into DNA-reactive metabolites was investigated in three immortalized rat hepatocyte cell lines (NRL cl-B, NRL cl-C and ARL) by analysing chromosome aberrations and sister chromatid exchange (SCE).	Benzo(a)pyrene	101-116	neural retina leucine zipper	Rattus norvegicus	279-282
8476845-5	1993	The benzo[a]pyrene ring of [BP]dG6 is intercalated between intact Watson-Crick dC5.dG18 and dC7.dG16 base pairs in a right-handed DNA helix.	Benzo(a)pyrene	4-18	l(3)91Fe	Drosophila melanogaster	79-82
8476845-5	1993	The benzo[a]pyrene ring of [BP]dG6 is intercalated between intact Watson-Crick dC5.dG18 and dC7.dG16 base pairs in a right-handed DNA helix.	Benzo(a)pyrene	4-18	E(rst)C7	Drosophila melanogaster	92-95
8482321-3	1993	Significant clastogenic effects were observed after an 18 h exposure to aflatoxin B1 and cyclophosphamide in CYP2B1 expressing cells, to benzo[a]pyrene in CYP1A1 and CYP1A2 expressing cells, to 7,12-dimethylbenz[a]anthracene and dimethylnitrosamine in cells, expressing CYP1A2 with or without acetyltransferase, and to cyclophosphamide in cells expressing both CYP1A2 and acetyltransferase.	Benzo(a)pyrene	137-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-161
8455606-6	1993	In accordance with the functional analysis, MATE-BP binding activities were detected in extracts prepared from myeloid cell lines such as THP-1, HL-60, and U-937 but not in HeLa cell extracts.	Benzo(a)pyrene	49-51	GLI family zinc finger 2	Homo sapiens	138-143
8432415-3	1993	Recent investigations have shown racial differences in the relationship between insulin resistance and BP in nondiabetic populations.	Benzo(a)pyrene	103-105	insulin	Homo sapiens	80-87
8097600-1	1993	The immunotoxic effects of the environmental carcinogen benzo[a]pyrene (BaP) have been evaluated using mouse, but not human, lymphocytes.	Benzo(a)pyrene	56-70	prohibitin 2	Mus musculus	72-75
8239995-1	1993	A high performance liquid chromatographic technique coupled with fluorometric detection was used to study the disappearance rate of the hemoglobin and albumin adducts of benzo(a)pyrene (BaP) in female Sprague-Dawley rats.	Benzo(a)pyrene	170-184	prohibitin 2	Rattus norvegicus	186-189
8383336-1	1993	Prostacyclin (PGI2) prevented genetic damage to the bone marrow cells of mice induced by gamma-radiation, benzo(a)pyrene(BP) and cis-platinum(cis-DDP).	Benzo(a)pyrene	106-120	prostaglandin I receptor (IP)	Mus musculus	14-18
8383336-1	1993	Prostacyclin (PGI2) prevented genetic damage to the bone marrow cells of mice induced by gamma-radiation, benzo(a)pyrene(BP) and cis-platinum(cis-DDP).	Benzo(a)pyrene	121-123	prostaglandin I receptor (IP)	Mus musculus	14-18
8424644-7	1993	Challenge of quiescent SMCs with 10% fetal bovine serum in the presence of BaP for 8 h enhanced serum-induced c-Ha-ras and c-myc protooncogene expression.	Benzo(a)pyrene	75-78	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	123-128
8225503-3	1993	Lung cancer patients who were recent smokers had significantly induced benzo[a]pyrene (BaP)-3-hydroxylase (AHH) and ethoxycoumarin O-deethylase activities in lung parenchyma compared with smoking non-cancer patients.	Benzo(a)pyrene	71-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-110
8225503-3	1993	Lung cancer patients who were recent smokers had significantly induced benzo[a]pyrene (BaP)-3-hydroxylase (AHH) and ethoxycoumarin O-deethylase activities in lung parenchyma compared with smoking non-cancer patients.	Benzo(a)pyrene	87-90	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-110
8216737-0	1993	Ki-ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice.	Benzo(a)pyrene	87-101	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-6
1332854-10	1992	DMBA and BP metabolism by PMSG-treated rat ovarian microsomes and untreated testicular microsomes are each completely inhibited by anti-P450RAP but are not inhibited by anti-P450IA1.	Benzo(a)pyrene	9-11	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	136-143
8280374-0	1993	Dose- and time-dependent expression of transforming growth factor-beta 1 mRNA and protein in mouse epidermis and papillomas after repeated topical application of benzo[a]pyrene.	Benzo(a)pyrene	162-176	transforming growth factor, beta 1	Mus musculus	39-72
8280374-1	1993	Topical weekly application of 64 micrograms of benzo[a]pyrene (BAP) for 4 wk induced transforming growth factor (TGF)-beta 1 mRNA in the epidermis of Swiss (ICR) mice, with a maximum at 6-12 h after the last treatment.	Benzo(a)pyrene	47-61	transforming growth factor, beta 1	Mus musculus	85-124
8280374-1	1993	Topical weekly application of 64 micrograms of benzo[a]pyrene (BAP) for 4 wk induced transforming growth factor (TGF)-beta 1 mRNA in the epidermis of Swiss (ICR) mice, with a maximum at 6-12 h after the last treatment.	Benzo(a)pyrene	63-66	transforming growth factor, beta 1	Mus musculus	85-124
8280374-4	1993	In contrast, after 20 weekly topical applications of 16 or 64 micrograms of BAP, an increase in TGF-beta 1 mRNA concentration and the appearance of extracellularly localized protein in the epidermis were observed.	Benzo(a)pyrene	76-79	transforming growth factor, beta 1	Mus musculus	96-106
8280374-7	1993	Papillomas resulting from treatment with 16 or 64 micrograms of BAP/wk for 28 wk stained for intracellularly localized TGF-beta 1 predominantly in the differentiating and nondividing layers.	Benzo(a)pyrene	64-67	transforming growth factor, beta 1	Mus musculus	119-129
8280374-9	1993	These results suggest that tumorigenesis by BAP involves the induction of cumulative changes in epidermal TGF-beta 1 mRNA and protein concentrations as well as alterations in skin morphology associated with a tumor-promotion process.	Benzo(a)pyrene	44-47	transforming growth factor, beta 1	Mus musculus	106-116
8280375-1	1993	In this study we analyzed the mutations in c-Ha-ras from skin papillomas initiated with benzo[a]pyrene (B[a]P), 7-methylbenz[a]anthracene (7-MBA), and 10-fluoro-7-methylbenz[a]anthracene (10-F-7-MBA) and from papillomas induced by treatment with tumor promoter alone.	Benzo(a)pyrene	88-102	Harvey rat sarcoma virus oncogene	Mus musculus	43-51
1280212-1	1992	Hs578T human breast cancer cells secrete insulin-like growth factor binding protein 3 (IGFBP-3) as the major BP species.	Benzo(a)pyrene	90-92	insulin like growth factor binding protein 3	Homo sapiens	41-85
22217852-1	1992	3alpha-Hydroxysteroid dehydrogenase and related enzymes play important roles in the metabolism of endogenous compounds including androgens, corticosteroid, prostaglandins and bile acids, as well as drugs and xenobiotics such as benzo(a)pyrene.	Benzo(a)pyrene	228-242	aldo-keto reductase family 1, member C14	Rattus norvegicus	0-35
1416973-4	1992	To accurately quantitate PBP binding and determine specific binding parameters, a reduction in the amount of charcoal used to adsorb nonspecifically bound benzo[a]pyrene was required.	Benzo(a)pyrene	155-169	phosphatidylethanolamine binding protein 1	Homo sapiens	25-28
1416973-5	1992	By saturation analysis, the concentration of specific binding sites for [3H]BP in PBP fraction from human liver was 4.6 pmol/mg of protein compared with 14.7 +/- 1.4 pmol/mg in the same fraction from DBA/2J mouse liver.	Benzo(a)pyrene	76-78	phosphatidylethanolamine binding protein 1	Homo sapiens	82-85
1486852-4	1992	We report use of this protocol to observe induced mutational spectra in exon 3 of the hprt gene in cultured human cells by benzo[a]pyrene-diol epoxide (BPDE), an active form of the widely distributed environmental carcinogen benzo[a]pyrene.	Benzo(a)pyrene	123-137	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	86-90
1435739-1	1992	Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	Benzo(a)pyrene	36-50	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	153-159
1464889-1	1992	The purpose of this study was to examine the relationship between insulin and BP in patients with normal glucose tolerance.	Benzo(a)pyrene	78-80	insulin	Homo sapiens	66-73
1412470-1	1992	Recent studies have demonstrated that macrophages are the cell types capable of metabolizing benzo[a]pyrene (B(a)P) within the spleens of untreated mice.	Benzo(a)pyrene	93-107	prohibitin 2	Mus musculus	109-114
1280788-3	1992	The baroreflex was checked indirectly by relating both the reflex prolongation in heart period (inter-beat-interval: IBI) and the reflex inhibition of SNA to a pharmacologically induced BP rise.	Benzo(a)pyrene	186-188	snail family transcriptional repressor 1	Rattus norvegicus	151-154
1516694-1	1992	Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P-450 1A1 was used to probe the effect of the lipid, dilauroyl-L-3-phosphatidylcholine, on this substrate-enzyme interaction.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-69
1516694-1	1992	Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P-450 1A1 was used to probe the effect of the lipid, dilauroyl-L-3-phosphatidylcholine, on this substrate-enzyme interaction.	Benzo(a)pyrene	42-44	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-69
1412511-0	1992	Benzo[a]pyrene and nicotine impair epidermal growth factor mediated cellular functions of buccal mucosa.	Benzo(a)pyrene	0-14	epidermal growth factor like 1	Rattus norvegicus	35-58
1381476-5	1992	P-450(Dah1) activated 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) most efficiently in the umu test and exhibited a high activity of aryl hydrocarbon hydroxylase toward benzo[a]pyrene.	Benzo(a)pyrene	225-239	Cytochrome P450 1A1	Canis lupus familiaris	6-10
1412511-1	1992	This study investigated the effect of two major ingredients in cigarette smoke, benzo[a]pyrene (BP) and nicotine, on epidermal growth factor (EGF) receptor binding and EGF-mediated cellular functions in rat buccal mucosa.	Benzo(a)pyrene	80-94	epidermal growth factor receptor	Rattus norvegicus	117-155
1412511-1	1992	This study investigated the effect of two major ingredients in cigarette smoke, benzo[a]pyrene (BP) and nicotine, on epidermal growth factor (EGF) receptor binding and EGF-mediated cellular functions in rat buccal mucosa.	Benzo(a)pyrene	80-94	epidermal growth factor like 1	Rattus norvegicus	142-145
1412511-1	1992	This study investigated the effect of two major ingredients in cigarette smoke, benzo[a]pyrene (BP) and nicotine, on epidermal growth factor (EGF) receptor binding and EGF-mediated cellular functions in rat buccal mucosa.	Benzo(a)pyrene	96-98	epidermal growth factor receptor	Rattus norvegicus	117-155
1412511-1	1992	This study investigated the effect of two major ingredients in cigarette smoke, benzo[a]pyrene (BP) and nicotine, on epidermal growth factor (EGF) receptor binding and EGF-mediated cellular functions in rat buccal mucosa.	Benzo(a)pyrene	96-98	epidermal growth factor like 1	Rattus norvegicus	142-145
1412511-6	1992	The results demonstrate that BP and nicotine change the buccal mucosal functions associated with alteration of EGF receptor.	Benzo(a)pyrene	29-31	epidermal growth factor like 1	Rattus norvegicus	111-114
1520328-2	1992	In contrast to negligible activities in the intact mouse liver, both ALDH3c and ALDH3m enzyme activities are inducible by benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mouse hepatoma Hepa-1c1c7 cell cultures.	Benzo(a)pyrene	122-136	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	69-74
1516151-0	1992	Organ-selective induction of cytochrome P-450-dependent activities by indole-3-carbinol-derived products: influence on covalent binding of benzo[a]pyrene to hepatic and pulmonary DNA in the rat.	Benzo(a)pyrene	139-153	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	29-45
1385071-10	1992	The effect of BaP on Dopa-decarboxylase was not consistent.	Benzo(a)pyrene	14-17	dopa decarboxylase	Mus musculus	21-39
1611989-10	1992	Hydrocortisone had an even more pronounced effect in stimulating the low level resorption of the osteocalcin-deficient BP implants than of the normal BP implants.	Benzo(a)pyrene	119-121	bone gamma-carboxyglutamate protein	Rattus norvegicus	97-108
1614866-2	1992	TOTO and YOYO are virtually non-fluorescent in solution, but form highly fluorescent complexes with double-stranded DNA (dsDNA), up to a maximum dye to DNA bp ratio of 1:4, with greater than 1000-fold fluorescence enhancement.	Benzo(a)pyrene	156-158	HOP homeobox	Homo sapiens	0-4
1494976-6	1992	Cytochrome P-450 levels and related biotransformation activity which are elevated by BP treatment were not decreased by the injection of BP and carrageenan simultaneously to male rats.	Benzo(a)pyrene	85-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
1635913-0	1992	Enhanced glutathione S-transferase (GST) activity in pregnant rats treated with benzo(a)pyrene.	Benzo(a)pyrene	80-94	hematopoietic prostaglandin D synthase	Rattus norvegicus	9-34
1635913-0	1992	Enhanced glutathione S-transferase (GST) activity in pregnant rats treated with benzo(a)pyrene.	Benzo(a)pyrene	80-94	hematopoietic prostaglandin D synthase	Rattus norvegicus	36-39
1562722-9	1992	These studies suggest that while hematopoietic growth factor granulocyte CSF-, granulocyte-macrophage CSF-, interleukin-3 (IL-3)-, or IL-6-, whose receptors are members of the hematopoietin receptor family, induced cell proliferation is associated with a common mechanism involving nuclear localization of the 68-Kd CaM-BP, the CSF-1-induced proliferation seems to involve 68-Kd CaM-BP-independent pathways.	Benzo(a)pyrene	320-322	interleukin 3	Mus musculus	123-127
1562722-9	1992	These studies suggest that while hematopoietic growth factor granulocyte CSF-, granulocyte-macrophage CSF-, interleukin-3 (IL-3)-, or IL-6-, whose receptors are members of the hematopoietin receptor family, induced cell proliferation is associated with a common mechanism involving nuclear localization of the 68-Kd CaM-BP, the CSF-1-induced proliferation seems to involve 68-Kd CaM-BP-independent pathways.	Benzo(a)pyrene	320-322	interleukin 6	Mus musculus	134-138
1562722-9	1992	These studies suggest that while hematopoietic growth factor granulocyte CSF-, granulocyte-macrophage CSF-, interleukin-3 (IL-3)-, or IL-6-, whose receptors are members of the hematopoietin receptor family, induced cell proliferation is associated with a common mechanism involving nuclear localization of the 68-Kd CaM-BP, the CSF-1-induced proliferation seems to involve 68-Kd CaM-BP-independent pathways.	Benzo(a)pyrene	320-322	colony stimulating factor 1 (macrophage)	Mus musculus	328-333
1557221-7	1992	Under GH treatment the hormone binding to high affinity BP (GH-BP II) increased in every patient to reach the mean value of 18.5 +/- 1.4%.	Benzo(a)pyrene	56-58	growth hormone receptor	Homo sapiens	60-65
1547225-7	1992	Microsomal suppression of rCYP2B1 catalytic activity was also observed for benzo[a]pyrene.	Benzo(a)pyrene	75-89	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	26-33
1643262-1	1992	The two DNA adducts of benzo[a]pyrene (BP) previously identified in vitro and in vivo are the stable adduct formed by reaction of the bay-region diol epoxide of BP (BPDE) at C-10 with the 2-amino group of dG (BPDE-10-N2dG) and the adduct formed by reaction of BP radical cation at C-6 with the N-7 of Gua (BP-6-N7Gua), which is lost from DNA by depurination.	Benzo(a)pyrene	23-37	complement C6	Rattus norvegicus	281-284
1643262-1	1992	The two DNA adducts of benzo[a]pyrene (BP) previously identified in vitro and in vivo are the stable adduct formed by reaction of the bay-region diol epoxide of BP (BPDE) at C-10 with the 2-amino group of dG (BPDE-10-N2dG) and the adduct formed by reaction of BP radical cation at C-6 with the N-7 of Gua (BP-6-N7Gua), which is lost from DNA by depurination.	Benzo(a)pyrene	39-41	complement C6	Rattus norvegicus	281-284
1643262-1	1992	The two DNA adducts of benzo[a]pyrene (BP) previously identified in vitro and in vivo are the stable adduct formed by reaction of the bay-region diol epoxide of BP (BPDE) at C-10 with the 2-amino group of dG (BPDE-10-N2dG) and the adduct formed by reaction of BP radical cation at C-6 with the N-7 of Gua (BP-6-N7Gua), which is lost from DNA by depurination.	Benzo(a)pyrene	161-163	complement C6	Rattus norvegicus	281-284
1643262-1	1992	The two DNA adducts of benzo[a]pyrene (BP) previously identified in vitro and in vivo are the stable adduct formed by reaction of the bay-region diol epoxide of BP (BPDE) at C-10 with the 2-amino group of dG (BPDE-10-N2dG) and the adduct formed by reaction of BP radical cation at C-6 with the N-7 of Gua (BP-6-N7Gua), which is lost from DNA by depurination.	Benzo(a)pyrene	161-163	complement C6	Rattus norvegicus	281-284
1643262-2	1992	In this paper we report identification of several new BP-DNA adducts formed by one-electron oxidation and the diol epoxide pathway, namely, BP bound at C-6 to the C-8 of Gua (BP-6-C8Gua) and the N-7 of Ade (BP-6-N7Ade) and BPDE bound at C-10 to the N-7 of Ade (BPDE-10-N7Ade).	Benzo(a)pyrene	54-56	complement C6	Rattus norvegicus	152-155
1643262-2	1992	In this paper we report identification of several new BP-DNA adducts formed by one-electron oxidation and the diol epoxide pathway, namely, BP bound at C-6 to the C-8 of Gua (BP-6-C8Gua) and the N-7 of Ade (BP-6-N7Ade) and BPDE bound at C-10 to the N-7 of Ade (BPDE-10-N7Ade).	Benzo(a)pyrene	140-142	complement C6	Rattus norvegicus	152-155
1643262-2	1992	In this paper we report identification of several new BP-DNA adducts formed by one-electron oxidation and the diol epoxide pathway, namely, BP bound at C-6 to the C-8 of Gua (BP-6-C8Gua) and the N-7 of Ade (BP-6-N7Ade) and BPDE bound at C-10 to the N-7 of Ade (BPDE-10-N7Ade).	Benzo(a)pyrene	140-142	complement C6	Rattus norvegicus	152-155
1574617-7	1992	As an example, this paper presents a simplified case study for children playing in soils contaminated with benzene and benzo(a)pyrene (BaP).	Benzo(a)pyrene	119-133	prohibitin 2	Homo sapiens	135-138
1537398-2	1992	Upon addition of various amounts of cytochrome P-450 to solutions of BaP, the T1 values for the three BaP protons decreased.	Benzo(a)pyrene	69-72	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52
1537398-0	1992	Proton NMR study of the interaction of benzo(a)pyrene with rat liver microsomal cytochrome P-450.	Benzo(a)pyrene	39-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	80-96
1537398-2	1992	Upon addition of various amounts of cytochrome P-450 to solutions of BaP, the T1 values for the three BaP protons decreased.	Benzo(a)pyrene	102-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52
1340664-8	1992	Moreover, an analytical and statistical study pointed out that BP levels of IDDM children seem to be influenced in addition to age, sex, height, weight, ponderal excess, as the general population, by the duration of the disease the insulin dose and some metabolic parameters (HbA1, HbA1c, glycemia, creatininemia).	Benzo(a)pyrene	63-65	hemoglobin subunit alpha 1	Homo sapiens	276-280
1463388-2	1992	FA and BaP activated by S9 from Aroclor 1254 (PCB)-treated rats induce HPRT mutations in CHO cells with about equal effectiveness at the same exposure doses, which also lead to the same frequencies of repairable DNA adducts, enzyme-induced strand breaks being used as an indirect measure of adducts to DNA.	Benzo(a)pyrene	7-10	pyruvate carboxylase	Rattus norvegicus	46-49
1463388-2	1992	FA and BaP activated by S9 from Aroclor 1254 (PCB)-treated rats induce HPRT mutations in CHO cells with about equal effectiveness at the same exposure doses, which also lead to the same frequencies of repairable DNA adducts, enzyme-induced strand breaks being used as an indirect measure of adducts to DNA.	Benzo(a)pyrene	7-10	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	71-75
1581531-6	1992	32P-Postlabeling analysis of DNA adducts produced following topical administration of benzo[a]pyrene to mouse skin suggests that cytochrome P-450 plays a major role in its metabolism to DNA binding derivatives.	Benzo(a)pyrene	86-100	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	129-145
1733576-0	1992	Stimulation of TGF-beta 1 mRNA concentration in mouse skin treated with benzo[a]pyrene.	Benzo(a)pyrene	72-86	transforming growth factor, beta 1	Mus musculus	15-25
1733576-1	1992	Topical application of benzo[a]pyrene (B[a]P) at dose rates of 32 or 64 micrograms/week to the dorsal skin of female Swiss (ICR) mice resulted in a marked and rapid increase in concentration of RNA for transforming growth factor beta 1 (TGF-beta 1) in epidermis.	Benzo(a)pyrene	23-37	transforming growth factor, beta 1	Mus musculus	202-235
1733576-1	1992	Topical application of benzo[a]pyrene (B[a]P) at dose rates of 32 or 64 micrograms/week to the dorsal skin of female Swiss (ICR) mice resulted in a marked and rapid increase in concentration of RNA for transforming growth factor beta 1 (TGF-beta 1) in epidermis.	Benzo(a)pyrene	23-37	transforming growth factor, beta 1	Mus musculus	237-247
1581533-12	1992	The stereochemistry of epoxidation of the enantiomers of BP-7,8-diol indicates that cytochrome P-450 catalyzes the terminal activation step of benzo[a]pyrene activation to an ultimate carcinogen in mouse skin, a target organ for its carcinogenic activity.	Benzo(a)pyrene	143-157	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	84-100
1554413-7	1992	Transient exposure of c-myc-expressing clones to BP and MNNG induced the formation of distinct, large colonies in soft agar, whereas the untreated cells formed microcolonies and the parental Rat 6 cells remained single cells in soft agar.	Benzo(a)pyrene	49-51	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	22-27
1316759-4	1992	In this study, we used the PAH isomers benzo[a]pyrene (BaP) and benzo[e]pyrene (BeP) to further evaluate the role of the 4S PAH-binding protein in induction of the CYP1A1 gene in H4-II-E rat hepatoma cells.	Benzo(a)pyrene	39-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	164-170
1316759-5	1992	Although BaP is believed to bind to both the Ah receptor and the 4S protein, BeP has been reported to bind exclusively to the 4S protein.	Benzo(a)pyrene	9-12	aryl hydrocarbon receptor	Rattus norvegicus	45-56
1316759-6	1992	The results of the study presented here indicate that BaP and BeP induce the expression of the CYP1A1 gene, as measured by ethoxyresorufin O-deethylase (EROD) activity, in a concentration-dependent manner.	Benzo(a)pyrene	54-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	95-101
1316759-8	1992	Slot-blot analysis of total RNA isolated from these cells indicated that BeP, BaP, and 3-methylcholanthrene increased the level of CYP1A1 mRNA expression.	Benzo(a)pyrene	78-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	131-137
1331828-2	1992	Syngenic Lewis rats were immunized with viable tumor cells, induced with benzo(a)pyrene, continuously producing BP 6 virus.	Benzo(a)pyrene	73-87	Blood pressure QTL 6	Rattus norvegicus	112-116
1933877-4	1991	Thirteen of 14 nucleotide residues of the p53 gene which underwent G:C to T:A mutations in lung cancers were targeted by benzo(a)pyrene.	Benzo(a)pyrene	121-135	tumor protein p53	Homo sapiens	42-45
1787769-15	1991	infusion of 0.8 M NaCl and the subpressor dose of Ang II completely prevented increase in the BP, suggesting that the presence of the intact sympathetic nervous system is necessary for the development of BP elevation in response to i.c.v.	Benzo(a)pyrene	94-96	angiogenin	Rattus norvegicus	50-53
1800893-3	1991	In the genetically engineered cell lines, benzo[a]pyrene was metabolized specifically by the 3-methylcholanthrene inducible rat liver CYP1A1 (cell line XEM2) whereas cyclophosphamide increased the micronucleus frequency only in cultures expressing the phenobarbital inducible CYP2B1 (SD1).	Benzo(a)pyrene	42-56	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	134-140
1654865-1	1991	The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Benzo(a)pyrene	236-250	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-89
1654865-1	1991	The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Benzo(a)pyrene	236-250	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	91-94
1654865-1	1991	The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Benzo(a)pyrene	252-254	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-89
1654865-1	1991	The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Benzo(a)pyrene	252-254	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	91-94
1654865-7	1991	As with Hepa-1, the human LS180 cytosolic AhR sedimented at about 9 S on sucrose gradients when detected with [3H]TCDD, [3H]BP or [3H]MC.	Benzo(a)pyrene	124-126	aryl hydrocarbon receptor	Homo sapiens	42-45
1913623-0	1991	Effects of synthetic and naturally occurring flavonoids on benzo[a]pyrene metabolism by hepatic microsomes prepared from rats treated with cytochrome P-450 inducers.	Benzo(a)pyrene	59-73	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	139-155
1922139-4	1991	Benzo [a] pyrene (BaP) activity was within an intermediate range (100-1000 revertants/micrograms).	Benzo(a)pyrene	0-16	prohibitin 2	Homo sapiens	18-21
1759389-2	1991	Distinct increase of cytochrome P-450 catalytic activity with amidopyrine and benzo-a-pyrene as substrates of the I type was found after hypoxia, subsequent hyperoxia resulted in significant increase of amidopyrine and benzo-a-pyrene metabolism in liver and lung tissues and of aniline metabolism in liver tissue.	Benzo(a)pyrene	78-92	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-37
1800893-3	1991	In the genetically engineered cell lines, benzo[a]pyrene was metabolized specifically by the 3-methylcholanthrene inducible rat liver CYP1A1 (cell line XEM2) whereas cyclophosphamide increased the micronucleus frequency only in cultures expressing the phenobarbital inducible CYP2B1 (SD1).	Benzo(a)pyrene	42-56	CUP2Q35	Homo sapiens	284-287
1654904-3	1991	High positive correlation (r = 0.949) between the values of Vmax for reaction of NADPH-dependent anaerobic amaranch reduction and the relative content low spin forms of cytochrome P-450 determined by ESR in microsomes from liver of control and induced by PB, BP, IS and 4-MP rats was observed.	Benzo(a)pyrene	259-261	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	169-185
1759389-2	1991	Distinct increase of cytochrome P-450 catalytic activity with amidopyrine and benzo-a-pyrene as substrates of the I type was found after hypoxia, subsequent hyperoxia resulted in significant increase of amidopyrine and benzo-a-pyrene metabolism in liver and lung tissues and of aniline metabolism in liver tissue.	Benzo(a)pyrene	219-233	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	21-37
1906275-5	1991	Reductase had no effect in the presence of an anti-P450c monoclonal antibody which inhibits BP hydroxylation, which suggests that this monoclonal antibody binds P450c near its reductase binding region.	Benzo(a)pyrene	92-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	161-166
1956022-5	1991	Raised BP in diabetic nephropathy is probably sustained, in part at least, by sodium retention and inappropriate activity of the renin-angiotensin system.	Benzo(a)pyrene	7-9	renin	Homo sapiens	129-134
1956022-12	1991	Insulin resistance and compensatory hyperinsulinaemia might lead to an increase in BP by a number of putative mechanisms, such as enhancing renal sodium retention, by an effect on cell membrane ion exchange mechanisms or by enhancing activity of the sympathetic nervous system.	Benzo(a)pyrene	83-85	insulin	Homo sapiens	0-7
1867632-10	1991	When microsomes from yeast transformed with pCK-1 were incubated with benzo(a)pyrene (10 min, 10-160 microM), an estimated Km value of 7 microM was obtained.	Benzo(a)pyrene	70-84	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	44-49
1681104-4	1991	Since the induction of ACE by alcohol in hepatic cells has been disputed, the coincident elevation of serum ACE and gamma-GTP activities in hypertensive drinkers may support the contention that the close association between gamma-GTP levels and BP found in drinkers is not mainly related to the induction of gamma-GTP in the hepatic cells, but related to the hepatic cell damage caused by alcohol.	Benzo(a)pyrene	245-247	inactive glutathione hydrolase 2	Homo sapiens	116-125
1681104-4	1991	Since the induction of ACE by alcohol in hepatic cells has been disputed, the coincident elevation of serum ACE and gamma-GTP activities in hypertensive drinkers may support the contention that the close association between gamma-GTP levels and BP found in drinkers is not mainly related to the induction of gamma-GTP in the hepatic cells, but related to the hepatic cell damage caused by alcohol.	Benzo(a)pyrene	245-247	inactive glutathione hydrolase 2	Homo sapiens	224-233
1681104-4	1991	Since the induction of ACE by alcohol in hepatic cells has been disputed, the coincident elevation of serum ACE and gamma-GTP activities in hypertensive drinkers may support the contention that the close association between gamma-GTP levels and BP found in drinkers is not mainly related to the induction of gamma-GTP in the hepatic cells, but related to the hepatic cell damage caused by alcohol.	Benzo(a)pyrene	245-247	inactive glutathione hydrolase 2	Homo sapiens	224-233
1985961-7	1991	Immunoinhibition experiments suggest that P-450 2a further metabolizes the primary phenols produced by P-450c-catalyzed hydroxylation of benzo[a]pyrene.	Benzo(a)pyrene	137-151	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	103-109
1906275-0	1991	A fluorescence study of the interactions of benzo[a]pyrene, cytochrome P450c and NADPH-cytochrome P450 reductase.	Benzo(a)pyrene	44-58	cytochrome p450 oxidoreductase	Homo sapiens	81-112
1906275-1	1991	Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P450c was used to probe this substrate-enzyme binding interaction.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-65
1906275-1	1991	Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P450c was used to probe this substrate-enzyme binding interaction.	Benzo(a)pyrene	42-44	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-65
1906275-2	1991	Addition of NADPH-cytochrome P450 reductase, an essential electron carrier during P450 catalysis, resulted in increased quenching and thus strengthened binding of BP to P450c.	Benzo(a)pyrene	163-165	cytochrome p450 oxidoreductase	Homo sapiens	12-43
1906275-2	1991	Addition of NADPH-cytochrome P450 reductase, an essential electron carrier during P450 catalysis, resulted in increased quenching and thus strengthened binding of BP to P450c.	Benzo(a)pyrene	163-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	169-174
1906275-5	1991	Reductase had no effect in the presence of an anti-P450c monoclonal antibody which inhibits BP hydroxylation, which suggests that this monoclonal antibody binds P450c near its reductase binding region.	Benzo(a)pyrene	92-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-56
1707592-1	1991	The human CYP1A1 (cytochrome P1450) gene encodes an enzyme involved in the activation of procarcinogens, such as benzo[a]pyrene, to the ultimate reactive intermediate.	Benzo(a)pyrene	113-127	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	10-16
1707763-3	1991	We report here that the treatment of Lewis rats with IL-2-PE40 delayed and shortened the course of EAE induced by BP in adjuvant and dramatically prevented EAE mediated by anti-myelin basic protein T line cells.	Benzo(a)pyrene	114-116	interleukin 2	Rattus norvegicus	53-57
2025238-4	1991	The Ret BP-retinoid complex eluted at 195 mM NaCl during Mono Q column chromatography using a 0-300 nM NaCl gradient.	Benzo(a)pyrene	8-10	ret proto-oncogene	Gallus gallus	4-7
2025238-7	1991	Ret BP may act as an affinant for retinoids in the cell, and may serve to dispense the ligands to their respective functionally active sites.	Benzo(a)pyrene	4-6	ret proto-oncogene	Gallus gallus	0-3
2004437-6	1991	Compared with normal fibroblasts, cultured hyperapoB fibroblasts incubated with BP I, which appears to be the same protein as acylation-stimulating protein (ASP), showed 50% less stimulation of triglyceride acylation and cholesterol esterification, whereas BP II markedly stimulated cholesteryl ester formation, and BP III caused no difference in response vs normal fibroblasts.	Benzo(a)pyrene	257-259	bactericidal permeability increasing protein	Homo sapiens	80-84
1997525-3	1991	Since benzo[alpha]pyrene (BP) inhibits EGF binding and autophosphorylation in cultured human placental cells, particularly in early gestation, we also studied the effect of benzo[alpha]pyrene and other polycyclic aromatic hydrocarbons (PAHs) on EGF-mediated AIB uptake.	Benzo(a)pyrene	26-28	epidermal growth factor	Homo sapiens	39-42
1997525-10	1991	BP alone stimulated AIB uptake by both very early and late gestation cells and enhanced EGF-stimulated AIB uptake.	Benzo(a)pyrene	0-2	epidermal growth factor	Homo sapiens	88-91
1997525-13	1991	Our prior results demonstrated that BP more significantly inhibited EGF than IGF or insulin receptor binding as well as autophosphorylation in early gestation placenta, and that BP was the most potent of the PAHs tested.	Benzo(a)pyrene	36-38	epidermal growth factor	Homo sapiens	68-71
1648311-5	1991	An IGFBP of 34 kDa, which is the major BP in cerebrospinal fluid but also present in blood, shows a great affinity for IGF II whereas the others BPs show similar affinities for both IGFs.	Benzo(a)pyrene	6-8	insulin like growth factor 2	Bos taurus	119-125
1899617-3	1991	Indomethacin treatment was also found to reduce elevated prostaglandin E2 (PGE)2 levels in the skin of BP-treated mice, whereas PGE2 levels were not significantly raised in DMBA-treated mice.	Benzo(a)pyrene	103-105	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	71-80
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-44
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-49
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	132-134	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-44
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	132-134	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-49
1846026-6	1991	We found that at both doses of BP, the number of SCEs and BP-DNA adducts in bone marrow and in spleen cells was significantly higher in aryl hydrocarbon hydroxylase (AHH)-non-inducible (DBA/2) mice than in AHH-inducible (C57BL/6) mice.	Benzo(a)pyrene	31-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	136-164
1846026-6	1991	We found that at both doses of BP, the number of SCEs and BP-DNA adducts in bone marrow and in spleen cells was significantly higher in aryl hydrocarbon hydroxylase (AHH)-non-inducible (DBA/2) mice than in AHH-inducible (C57BL/6) mice.	Benzo(a)pyrene	31-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	166-169
1846026-6	1991	We found that at both doses of BP, the number of SCEs and BP-DNA adducts in bone marrow and in spleen cells was significantly higher in aryl hydrocarbon hydroxylase (AHH)-non-inducible (DBA/2) mice than in AHH-inducible (C57BL/6) mice.	Benzo(a)pyrene	31-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	206-209
1846026-10	1991	The present data confirm the influence of inducibility of AHH in the intestine on the genotoxicity of BP to distal tissues after oral exposure to BP.	Benzo(a)pyrene	102-104	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	58-61
1846026-10	1991	The present data confirm the influence of inducibility of AHH in the intestine on the genotoxicity of BP to distal tissues after oral exposure to BP.	Benzo(a)pyrene	146-148	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	58-61
1654602-6	1991	Two components of the monooxygenase system responsible for BP metabolism, cytochrome P-450 and NADPH-cytochrome P-450 reductase, are also inhibited by the two oxygen metabolites in a similar manner.	Benzo(a)pyrene	59-61	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-90
1871778-2	1991	At both timepoints, reduction in pulmonary P450 content was associated with a decrease in aryl hydrocarbon hydroxylase (AHH) activity, a detoxication pathway for benzo[a]pyrene (BaP).	Benzo(a)pyrene	162-176	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	90-118
1871778-2	1991	At both timepoints, reduction in pulmonary P450 content was associated with a decrease in aryl hydrocarbon hydroxylase (AHH) activity, a detoxication pathway for benzo[a]pyrene (BaP).	Benzo(a)pyrene	162-176	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	120-123
1871778-2	1991	At both timepoints, reduction in pulmonary P450 content was associated with a decrease in aryl hydrocarbon hydroxylase (AHH) activity, a detoxication pathway for benzo[a]pyrene (BaP).	Benzo(a)pyrene	178-181	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	90-118
1871778-2	1991	At both timepoints, reduction in pulmonary P450 content was associated with a decrease in aryl hydrocarbon hydroxylase (AHH) activity, a detoxication pathway for benzo[a]pyrene (BaP).	Benzo(a)pyrene	178-181	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	120-123
1654602-6	1991	Two components of the monooxygenase system responsible for BP metabolism, cytochrome P-450 and NADPH-cytochrome P-450 reductase, are also inhibited by the two oxygen metabolites in a similar manner.	Benzo(a)pyrene	59-61	cytochrome p450 oxidoreductase	Rattus norvegicus	95-127
2096947-1	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) inhibit the 0-deethylation of 7-ethoxyresorufin (ER) in liver microsomes of benz(a)pyrene-induced (BP) mice but do not inhibit the 0-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	219-221	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103
1982886-3	1990	Therefore, the associations between gamma-GTP and BP were analysed more minutely in 385 male and 1126 female non-drinkers.	Benzo(a)pyrene	50-52	inactive glutathione hydrolase 2	Homo sapiens	36-45
1982886-5	1990	The sex difference of BP disappeared after adjustment for serum gamma-GTP levels.	Benzo(a)pyrene	22-24	inactive glutathione hydrolase 2	Homo sapiens	64-73
1982886-7	1990	These results suggest that common or possibly similar mechanisms which relate to the elevation of serum gamma-GTP activity are involved in the production of high BP both in non-drinking obese persons and in drinkers.	Benzo(a)pyrene	162-164	inactive glutathione hydrolase 2	Homo sapiens	104-113
2096947-1	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) inhibit the 0-deethylation of 7-ethoxyresorufin (ER) in liver microsomes of benz(a)pyrene-induced (BP) mice but do not inhibit the 0-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	296-298	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103
2125771-11	1990	For example, when the mutagenicity of benzo(a)pyrene and benzo(a)pyrene-3,6-quinone was studied in the Ames test, glucuronidation or glutathione conjugation (concomitant with cytochrome P-450-dependent reactions) markedly decreased their mutagenicity.	Benzo(a)pyrene	38-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	175-191
2275212-2	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) both inhibit the O-deethylation of 7-ethoxy-resorufin (ER) in liver microsomes of benzo(a)pyrene-induced (BP) mice but do not inhibit the O-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	226-228	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103
2275212-2	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) both inhibit the O-deethylation of 7-ethoxy-resorufin (ER) in liver microsomes of benzo(a)pyrene-induced (BP) mice but do not inhibit the O-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	303-305	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103
2217169-2	1990	One clone identified by this procedure corresponded to a 1.4-kilobase mRNA, designated NB-1, whose expression was decreased greater than 50-fold in HMECs tumorigenically transformed in vitro after exposure to benzo[a]pyrene and Kirsten sarcoma virus.	Benzo(a)pyrene	209-223	CD177 molecule	Homo sapiens	87-91
2272311-10	1990	Enhanced expression of c-myc was detected in SHE cells transformed by benzo(a)pyrene or trenbolone.	Benzo(a)pyrene	70-84	myc proto-oncogene protein	Mesocricetus auratus	23-28
2236903-2	1990	Single organic- and water-soluble metabolites increased with BaP concentration in both types of HSF, but the ratio normal/variant increased with BaP concentration.	Benzo(a)pyrene	61-64	interleukin 6	Homo sapiens	96-99
2117502-1	1990	We report that, in a human cell line, human cytochrome P450IIA3 is capable of metabolizing aflatoxin B1, benzo[a]-pyrene, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) to cytotoxic and mutagenic species.	Benzo(a)pyrene	105-120	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	44-63
2194587-8	1990	The reactivity of BP-ALL with native P190bcr-abl derived from a Ph"-positive ALL cell line (TOM-1) was tested using immunoprecipitation analysis.	Benzo(a)pyrene	18-20	target of myb1 membrane trafficking protein	Homo sapiens	92-97
2372865-4	1990	In contrast, polycyclic aromatic hydrocarbons, such as 3-methylcholanthrene, benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, induce an immediate increase of T-ALDH activity in both cultured rat hepatocytes and hepatoma cell lines.	Benzo(a)pyrene	77-91	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	162-166
1973007-4	1990	The inducibility of AHH by BaP treatment was depressed by 30-70% in MCA and 7SA cells over a 36-hr time course.	Benzo(a)pyrene	27-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-23
1692256-3	1990	The AHH activity of cells treated with either benz(a)anthracene, benzo(a)pyrene, 3-methylcholanthrene, or TCDD continuously or 24 h before harvesting was measured during observation periods for up to 5 days.	Benzo(a)pyrene	65-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	4-7
1692256-4	1990	Slight induction of AHH activity by benz(a)anthracene, benzo(a)pyrene, and 3-methylcholanthrene was observed in hepatocytes from the CBA and C3H/He strains during the first half of the observation period, followed by a steep increase thereafter.	Benzo(a)pyrene	55-69	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-23
1693098-3	1990	The CD4+ T cells from BP/IFA-sensitized donors showed no proliferative response to BP and no change in cell size or surface molecule expression, even in the presence of BP in culture.	Benzo(a)pyrene	22-24	Cd4 molecule	Rattus norvegicus	4-7
1693098-5	1990	In this case, a large number of CD4+ blastoid T cells was generated only in the presence of BP in culture.	Benzo(a)pyrene	92-94	Cd4 molecule	Rattus norvegicus	32-35
1693098-6	1990	Such cells showed marked upregulation of CD4, CD2, class I and II MHC, and IL2 receptor molecules, a finding we also observed in the case of BP-cultured cells from BP/CFA-sensitized rats with severe EAE.	Benzo(a)pyrene	141-143	Cd4 molecule	Rattus norvegicus	41-44
1693098-6	1990	Such cells showed marked upregulation of CD4, CD2, class I and II MHC, and IL2 receptor molecules, a finding we also observed in the case of BP-cultured cells from BP/CFA-sensitized rats with severe EAE.	Benzo(a)pyrene	141-143	interleukin 2	Rattus norvegicus	75-78
1693098-7	1990	The proportion of CD4+ blastoid T cells generated after culture depended on the number of cells transferred and on the presence of BP in culture, and closely correlated with the severity of EAE in the recipients.	Benzo(a)pyrene	131-133	Cd4 molecule	Rattus norvegicus	18-21
2351129-1	1990	The metabolism of benzo[a]pyrene is mediated by the mixed function oxidase system including the cytochrome P450-dependent aryl hydrocarbon hydroxylase.	Benzo(a)pyrene	18-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	122-150
2161424-4	1990	Kinetic estimations are presented to show that the extent of binding of CRH to its BP (and, hence, the reduction in its bioactivity) depends on the time available for binding and the concentration of reactants.	Benzo(a)pyrene	83-85	corticotropin releasing hormone	Homo sapiens	72-75
2107605-7	1990	However, the vitamin A level was inversely related to the activities of drug metabolizing enzymes induced by coplanar compounds (cytochrome P-450 towards benzo[a]pyrene and UDP glucuronosyl transferase towards 4-nitrophenol).	Benzo(a)pyrene	154-168	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	129-145
2364062-0	1990	Binding of benzo[a]pyrene to DNA by cytochrome P-450 catalyzed one-electron oxidation in rat liver microsomes and nuclei.	Benzo(a)pyrene	11-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-52
2364062-4	1990	The specific cytochrome P-450 inhibitor 2-[(4,6-dichloro-o-biphenyl)oxy]ethylamine hydrobromide (DPEA) reduced or eliminated BP metabolism, binding of BP to DNA, and formation of BP-N7Gua by cytochrome P-450 in both microsomes and nuclei.	Benzo(a)pyrene	125-127	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
2364062-4	1990	The specific cytochrome P-450 inhibitor 2-[(4,6-dichloro-o-biphenyl)oxy]ethylamine hydrobromide (DPEA) reduced or eliminated BP metabolism, binding of BP to DNA, and formation of BP-N7Gua by cytochrome P-450 in both microsomes and nuclei.	Benzo(a)pyrene	151-153	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
2364062-4	1990	The specific cytochrome P-450 inhibitor 2-[(4,6-dichloro-o-biphenyl)oxy]ethylamine hydrobromide (DPEA) reduced or eliminated BP metabolism, binding of BP to DNA, and formation of BP-N7Gua by cytochrome P-450 in both microsomes and nuclei.	Benzo(a)pyrene	151-153	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	191-207
2342494-1	1990	The mutagenic activation of benzo[a]pyrene (BaP) after exposure to aorta smooth muscle cells of different origin was examined.	Benzo(a)pyrene	28-42	prohibitin 2	Rattus norvegicus	44-47
1690080-7	1990	Suppressor activity persisted after depletion of Thy 1.2+ cells, but suppression was no longer antigen-specific, suggesting that culture of spleen cells with CsA and BP may generate suppressor macrophages which are antigen-nonspecific and Thy 1.2+ suppressor cells which are antigen-specific.	Benzo(a)pyrene	166-168	thymus cell antigen 1, theta	Mus musculus	239-246
2107967-0	1990	Long term effects of benzo(a)pyrene on the activity of NAD(P)H:quinone reductase in the forestomach and glandular stomach of ICR/Ha mice.	Benzo(a)pyrene	21-35	crystallin, zeta	Mus musculus	63-80
2156686-10	1990	Intense GH receptor/BP immunoreactivity in the female reproductive system was evident in the germinal epithelium, the vascular endothelium of the myometrium, the epithelial lining of the fimbriae and oviduct, the endometrial epithelium and scattered endometrial glands, the mesothelium of the perimetrium, and the vascular endothelium of the endometrium.	Benzo(a)pyrene	20-22	growth hormone receptor	Rattus norvegicus	8-19
1690749-2	1990	To evaluate these alternative models we examined the IGF-binding characteristics and behavior on an SP-Sephadex ion exchange column of BP species identified by chemically cross-linking [125I]IGF-I and [125I]IGF-II.	Benzo(a)pyrene	135-137	insulin like growth factor 1	Homo sapiens	191-196
2085400-1	1990	The B(a)P [Benzo(a)pyrene] contents of 20 Chinese herbal drugs before and after charring were determined for the first time.	Benzo(a)pyrene	11-25	prohibitin 2	Homo sapiens	4-9
2297758-3	1990	We now show that synthetic CLA inhibits the initiation of mouse forestomach tumorigenesis by benzo(a)pyrene.	Benzo(a)pyrene	93-107	clasper	Mus musculus	27-30
2299644-2	1990	The PBP binds polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (B[a]P), with high affinity and shows other characteristics associated with receptor-ligand complexes.	Benzo(a)pyrene	56-70	phosphatidylethanolamine binding protein 1	Mus musculus	4-7
2299644-2	1990	The PBP binds polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (B[a]P), with high affinity and shows other characteristics associated with receptor-ligand complexes.	Benzo(a)pyrene	72-77	phosphatidylethanolamine binding protein 1	Mus musculus	4-7
1691820-3	1990	The predicted amino acid sequence of rat IGFBP-1 showed 66%, 29%, and 34% sequence identity with the human IGFBP-1, the human GH-dependent binding protein IGFBP-3, and rat IGFBP-2, the BP secreted by buffalo rat liver cells, respectively.	Benzo(a)pyrene	44-46	insulin like growth factor binding protein 1	Homo sapiens	107-114
2154666-1	1990	Studies investigated the effects of benzo(a)pyrene (BP) treatment on epidermal growth factor (EGF) receptor binding and kinase activity in human placental cell cultures.	Benzo(a)pyrene	36-50	epidermal growth factor receptor	Homo sapiens	69-107
2154666-1	1990	Studies investigated the effects of benzo(a)pyrene (BP) treatment on epidermal growth factor (EGF) receptor binding and kinase activity in human placental cell cultures.	Benzo(a)pyrene	52-54	epidermal growth factor receptor	Homo sapiens	69-107
2154666-2	1990	Specific binding of 125I-EGF to cells from early gestation placentae was significantly decreased by 37 and 60% following exposure to 1 and 10 microM BP, respectively, for 24 hr.	Benzo(a)pyrene	149-151	epidermal growth factor	Homo sapiens	25-28
2154666-5	1990	Scatchard analysis of early gestation cells revealed that BP was associated with a dose-dependent loss in the number of high affinity EGF binding sites.	Benzo(a)pyrene	58-60	epidermal growth factor	Homo sapiens	134-137
2154666-8	1990	Thus, early gestation cells exhibit a BP-related down-regulation of EGF receptors, whereas term placental cells show receptor desensitization.	Benzo(a)pyrene	38-40	epidermal growth factor	Homo sapiens	68-71
2154666-11	1990	In early gestation cells, EGF binding and receptor autophosphorylation were measurably decreased at 10 microM concentrations of these polycyclic compounds, but to a lesser extent than observed with BP.	Benzo(a)pyrene	198-200	epidermal growth factor	Homo sapiens	26-29
2154666-15	1990	In summary, the direct effects of BP and related compounds observed on placental EGF receptors may indicate altered function of EGF in the regulation of cell growth and differentiation in the human placenta.	Benzo(a)pyrene	34-36	epidermal growth factor	Homo sapiens	81-84
2154666-15	1990	In summary, the direct effects of BP and related compounds observed on placental EGF receptors may indicate altered function of EGF in the regulation of cell growth and differentiation in the human placenta.	Benzo(a)pyrene	34-36	epidermal growth factor	Homo sapiens	128-131
2206099-7	1990	Measurements of mucosal enzyme activities suggest adaptation to the diets especially in the ileum as indicated by increasing aminopeptidase N and dipeptidyl peptidase IV specific activities in the BP-fed group.	Benzo(a)pyrene	197-199	alanyl aminopeptidase, membrane	Rattus norvegicus	125-141
1691820-3	1990	The predicted amino acid sequence of rat IGFBP-1 showed 66%, 29%, and 34% sequence identity with the human IGFBP-1, the human GH-dependent binding protein IGFBP-3, and rat IGFBP-2, the BP secreted by buffalo rat liver cells, respectively.	Benzo(a)pyrene	44-46	insulin like growth factor binding protein 3	Homo sapiens	155-162
1691820-3	1990	The predicted amino acid sequence of rat IGFBP-1 showed 66%, 29%, and 34% sequence identity with the human IGFBP-1, the human GH-dependent binding protein IGFBP-3, and rat IGFBP-2, the BP secreted by buffalo rat liver cells, respectively.	Benzo(a)pyrene	44-46	insulin-like growth factor binding protein 2	Rattus norvegicus	172-179
2072980-5	1990	It is postulated that different cytochrome P-450 isoenzymes participate in benzo(a)pyrene hydroxylation, whereas the second one acts at high concentration of both NADH and NADPH.	Benzo(a)pyrene	75-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-48
2206099-7	1990	Measurements of mucosal enzyme activities suggest adaptation to the diets especially in the ileum as indicated by increasing aminopeptidase N and dipeptidyl peptidase IV specific activities in the BP-fed group.	Benzo(a)pyrene	197-199	dipeptidylpeptidase 4	Rattus norvegicus	146-169
2253602-1	1990	The results of both the Salmonella/microsome mutagenicity assay and high-performance liquid chromatography (HPLC) analysis were used to evaluate the interactions of binary mixtures of benzo(a)pyrene (BAP) and several different polychlorinated aromatic hydrocarbons.	Benzo(a)pyrene	184-198	prohibitin 2	Homo sapiens	200-203
2364459-2	1990	When benzo[a]pyrene pretreated mice intoxicated with 400 mg/kg AAP were pretreated 2 h before with 1 g/kg phosphatidylcholine liposomes containing 4 mg/kg vitamin E acetate, these animals were protected against liver damage.	Benzo(a)pyrene	5-19	active avoidance performance	Mus musculus	63-66
2097279-0	1990	[Effect of monoclonal antibody against methylcholanthrene-induced cytochrome P-450 forms on benzo(a)pyrene metabolism in hepatic microsomes of C57BL/10 mice].	Benzo(a)pyrene	92-106	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	66-82
2290140-13	1990	We conclude that BP and HR levels measured in the laboratory generalizes to real life BP and HR in both men and women and also to real life SBP reactivity in men.	Benzo(a)pyrene	17-19	selenium binding protein 1	Homo sapiens	140-143
2184316-0	1990	The mutagenic activity of ethylmethanesulphonate, benzidine and benzo[a]pyrene at the hprt locus of wild-type L5178Y mouse lymphoma cells.	Benzo(a)pyrene	64-78	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	86-90
2184316-1	1990	Ethylmethanesulphonate (EMS), benzidine (BZD) and benzo[a]pyrene (B[a]P) were assayed for ability to induce mutation at the hprt locus of wild-type L5178Y mouse lymphoma cells.	Benzo(a)pyrene	50-64	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	124-128
2184322-3	1990	The induction of mutations at both the thymidine kinase (tk) locus and the hypoxanthine guanine phosphoribosyl transferase (hprt) locus was determined following exposure to ethyl methanesulphonate (EMS), benzidine (BZD) and benzo[a]pyrene (B[a]P).	Benzo(a)pyrene	224-238	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	75-122
2134689-5	1990	The P-450 catalyzed benzo[a]pyrene and tolbutamide hydroxylations and cyclophosphamide oxidation, but showed low activity for the mutagenic activation of IQ (2-amino-3-methylimidazo [4, 5-f]quinoline).	Benzo(a)pyrene	20-34	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-9
2343577-6	1990	The primary metabolism of the hydrophobic BP involved cytochrome P-450 isoenzymes which had the active site directed inside the lipids; the secondary metabolism of more polar diols was realized using both groups of hemoprotein isoenzymes with active sites oriented into lipids and water.	Benzo(a)pyrene	42-44	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70
33774063-9	2021	In co-exposure experiments, DTS suppressed CYP1A activity induced by both B[a]P and PCB-126, although these reductions were not significant.	Benzo(a)pyrene	74-79	cytochrome P450, family 1, subfamily A	Danio rerio	43-48
2328803-1	1990	The long-term administration of xenobiotics carcinogens o-aminoazotoluene (o-AAT) and benz(a)pyrene (BP) to rats was found to cause induction of the liver cytochrome P-450 system which gradually decreases in spite of continued administration of the agents.	Benzo(a)pyrene	86-99	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	155-171
2328803-1	1990	The long-term administration of xenobiotics carcinogens o-aminoazotoluene (o-AAT) and benz(a)pyrene (BP) to rats was found to cause induction of the liver cytochrome P-450 system which gradually decreases in spite of continued administration of the agents.	Benzo(a)pyrene	101-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	155-171
33813368-0	2021	Taxifolin ameliorates Benzo[a]pyrene-induced lung injury possibly via stimulating the Nrf2 signalling pathway.	Benzo(a)pyrene	22-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
33800341-4	2021	Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself.	Benzo(a)pyrene	32-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-120
33800341-4	2021	Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself.	Benzo(a)pyrene	32-37	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	121-127
33800341-4	2021	Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself.	Benzo(a)pyrene	230-235	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-120
22951985-2	2012	Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concentrations activating the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	31-33	Fas cell surface death receptor	Homo sapiens	88-92
22951985-2	2012	Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concentrations activating the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	31-33	aryl hydrocarbon receptor	Homo sapiens	199-202
22951985-2	2012	Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concentrations activating the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	136-138	Fas cell surface death receptor	Homo sapiens	88-92
22951985-2	2012	Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concentrations activating the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	136-138	aryl hydrocarbon receptor	Homo sapiens	172-197
22951985-2	2012	Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fas)-mediated apoptosis was observed with BP at concentrations activating the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	136-138	aryl hydrocarbon receptor	Homo sapiens	199-202
22951985-7	2012	Exposure to BP did not increase expression of CD95, but led to augmented activation of caspase-8.	Benzo(a)pyrene	12-14	caspase 8	Homo sapiens	87-96
21150308-6	2011	We show that challenge of HeLa cells with BaP induces early enrichment of the transcriptionally-active chromatin markers histone H3 trimethylated at lysine 4 (H3K4Me3) and histone H3 acetylated at lysine 9 (H3K9Ac), and reduces association of DNA methyltransferase-1 (DNMT1) with the L1 promoter.	Benzo(a)pyrene	42-45	DNA methyltransferase 1	Homo sapiens	243-266
21150308-6	2011	We show that challenge of HeLa cells with BaP induces early enrichment of the transcriptionally-active chromatin markers histone H3 trimethylated at lysine 4 (H3K4Me3) and histone H3 acetylated at lysine 9 (H3K9Ac), and reduces association of DNA methyltransferase-1 (DNMT1) with the L1 promoter.	Benzo(a)pyrene	42-45	DNA methyltransferase 1	Homo sapiens	268-273
21150308-9	2011	We conclude that genetic reactivation of L1 by BaP involves an ordered cascade of epigenetic events that begin with nucleosomal histone modifications and is completed with alterations in DNMT1 recruitment to the L1 promoter and reduced DNA methylation of CpG islands.	Benzo(a)pyrene	47-50	DNA methyltransferase 1	Homo sapiens	187-192
7835217-2	1994	In perfused liver, benzo(a)pyrene (4-120 microM) in 0.3% albumin increased fluorescence (366-->405 mm) on the liver surface in a dose-dependent manner, suggesting that it accumulated in liver tissue.	Benzo(a)pyrene	19-33	albumin	Rattus norvegicus	57-64
8080457-6	1994	One dose of benzo[a]pyrene for 24 hr increased ALDH3c activity by 25-fold.	Benzo(a)pyrene	12-26	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	47-52
8080457-7	1994	Treatment with both the GSH-depleting chemicals and benzo[a]pyrene inhibited ALDH3c induction by 45% to 75%, suggesting a role for GSH during ALDH3c induction.	Benzo(a)pyrene	52-66	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	77-82
8080457-7	1994	Treatment with both the GSH-depleting chemicals and benzo[a]pyrene inhibited ALDH3c induction by 45% to 75%, suggesting a role for GSH during ALDH3c induction.	Benzo(a)pyrene	52-66	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	142-147
34906874-5	2022	In addition, the AOP network was quantitatively evaluated with omics approaches and bioassays, using 16HBE-CYP1A1 cells exposed to benzo(a)pyrene (BaP), a prototypical AHR activator.	Benzo(a)pyrene	131-145	aryl hydrocarbon receptor	Homo sapiens	168-171
34906874-5	2022	In addition, the AOP network was quantitatively evaluated with omics approaches and bioassays, using 16HBE-CYP1A1 cells exposed to benzo(a)pyrene (BaP), a prototypical AHR activator.	Benzo(a)pyrene	147-150	aryl hydrocarbon receptor	Homo sapiens	168-171
34953351-9	2022	In conclusion, Pae improves the IVM capacity of BaP-treated porcine oocytes by activating the SHH signaling pathway, inhibiting ROS production, and increasing DeltaPsi.	Benzo(a)pyrene	48-51	sonic hedgehog signaling molecule	Homo sapiens	94-97
34653861-3	2022	By means of molecular dynamics simulation, here we investigate adsorption of benzo(a)pyrene (BaP) and heavy metal ions (Cu2+) on nanoplastics of different materials and surface charges regulated by humic acid (HA).	Benzo(a)pyrene	77-91	prohibitin 2	Homo sapiens	93-96
34991250-5	2022	Exposure to benzo(a)pyrene (B(a)P) and dioxin-like polychlorinated biphenyl (PCB) 126 resulted in a rapid c-Src-mediated phosphorylation of EGFR.	Benzo(a)pyrene	12-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	106-111
34387821-8	2022	Phosphorylated IkappaBalpha was elevated in BaP-exposed mouse lungs.	Benzo(a)pyrene	44-47	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	15-27
34387821-9	2022	Nuclear translocation of NF-kappaB p65 and p50 was accordingly observed in BaP-exposed mouse lungs.	Benzo(a)pyrene	75-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-46
34387821-13	2022	In addition, NAC attenuated BaP-induced NF-kappaB activation in A549 cells and mouse lungs.	Benzo(a)pyrene	28-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
34529316-0	2022	Phosphorylation of p53 by Cdk5 contributes to benzo(a)pyrene-induced neuronal apoptosis.	Benzo(a)pyrene	46-60	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	19-22
34529316-0	2022	Phosphorylation of p53 by Cdk5 contributes to benzo(a)pyrene-induced neuronal apoptosis.	Benzo(a)pyrene	46-60	cyclin-dependent kinase 5	Rattus norvegicus	26-30
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	48-51	glutamic pyruvic transaminase, soluble	Mus musculus	135-155
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	48-51	glutamic pyruvic transaminase, soluble	Mus musculus	157-160
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	48-51	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	163-185
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	48-51	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	187-190
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	328-331	glutamic pyruvic transaminase, soluble	Mus musculus	135-155
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	328-331	glutamic pyruvic transaminase, soluble	Mus musculus	157-160
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	328-331	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	163-185
34856318-8	2022	Results showed that the mice treated with SDG + BaP had significantly (P < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities, and less levels of serum creatinine (CRE) and blood urea nitrogen (BUN) than those treated with BaP alone.	Benzo(a)pyrene	328-331	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	187-190
34856318-10	2022	Furthermore, it significantly (P < 0.05) downregulated phosphor-p38 (p-p38) and phosphor-extracellular regulated protein kinases (p-ERK) levels, upregulated mitogen-activated protein kinase phosphatase-1 (MKP-1) level, and suppressed miR-101a expression compared with BaP alone group.	Benzo(a)pyrene	268-271	mitogen-activated protein kinase 14	Mus musculus	71-74
34856318-10	2022	Furthermore, it significantly (P < 0.05) downregulated phosphor-p38 (p-p38) and phosphor-extracellular regulated protein kinases (p-ERK) levels, upregulated mitogen-activated protein kinase phosphatase-1 (MKP-1) level, and suppressed miR-101a expression compared with BaP alone group.	Benzo(a)pyrene	268-271	mitogen-activated protein kinase 1	Mus musculus	132-135
34856318-10	2022	Furthermore, it significantly (P < 0.05) downregulated phosphor-p38 (p-p38) and phosphor-extracellular regulated protein kinases (p-ERK) levels, upregulated mitogen-activated protein kinase phosphatase-1 (MKP-1) level, and suppressed miR-101a expression compared with BaP alone group.	Benzo(a)pyrene	268-271	dual specificity phosphatase 1	Mus musculus	157-203
34856318-10	2022	Furthermore, it significantly (P < 0.05) downregulated phosphor-p38 (p-p38) and phosphor-extracellular regulated protein kinases (p-ERK) levels, upregulated mitogen-activated protein kinase phosphatase-1 (MKP-1) level, and suppressed miR-101a expression compared with BaP alone group.	Benzo(a)pyrene	268-271	dual specificity phosphatase 1	Mus musculus	205-210
34856318-10	2022	Furthermore, it significantly (P < 0.05) downregulated phosphor-p38 (p-p38) and phosphor-extracellular regulated protein kinases (p-ERK) levels, upregulated mitogen-activated protein kinase phosphatase-1 (MKP-1) level, and suppressed miR-101a expression compared with BaP alone group.	Benzo(a)pyrene	268-271	microRNA 101a	Mus musculus	234-242
34991250-5	2022	Exposure to benzo(a)pyrene (B(a)P) and dioxin-like polychlorinated biphenyl (PCB) 126 resulted in a rapid c-Src-mediated phosphorylation of EGFR.	Benzo(a)pyrene	12-26	epidermal growth factor receptor	Homo sapiens	140-144
34991250-5	2022	Exposure to benzo(a)pyrene (B(a)P) and dioxin-like polychlorinated biphenyl (PCB) 126 resulted in a rapid c-Src-mediated phosphorylation of EGFR.	Benzo(a)pyrene	28-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	106-111
34991250-5	2022	Exposure to benzo(a)pyrene (B(a)P) and dioxin-like polychlorinated biphenyl (PCB) 126 resulted in a rapid c-Src-mediated phosphorylation of EGFR.	Benzo(a)pyrene	28-33	epidermal growth factor receptor	Homo sapiens	140-144
34890772-0	2022	The behavioral effects of gestational and lactational benzo(a)pyrene exposure vary by sex and genotype in mice with differences at the Ahr and Cyp1a2 loci.	Benzo(a)pyrene	54-68	aryl-hydrocarbon receptor	Mus musculus	135-138
34890772-0	2022	The behavioral effects of gestational and lactational benzo(a)pyrene exposure vary by sex and genotype in mice with differences at the Ahr and Cyp1a2 loci.	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	143-149
34890772-4	2022	Our studies were designed to look for genotype and sex differences in susceptibility to gestational and lactational exposure to BaP using a mouse model with allelic differences in the aryl hydrocarbon receptor and the xenobiotic metabolizing enzyme CYP1A2.	Benzo(a)pyrene	128-131	aryl-hydrocarbon receptor	Mus musculus	184-209
34890772-4	2022	Our studies were designed to look for genotype and sex differences in susceptibility to gestational and lactational exposure to BaP using a mouse model with allelic differences in the aryl hydrocarbon receptor and the xenobiotic metabolizing enzyme CYP1A2.	Benzo(a)pyrene	128-131	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	249-255
34890772-9	2022	BaP-treated high-affinity AhrbCyp1a2(-/-) mice had greater impairments in Morris water maze.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	26-36
34635253-1	2022	A conjugated microporous organic polymer (TPA-Bp) comprised of triphenylamine (TPA) and 2,2"-bipyridine-5,5"-diformaldehyde (Bp) was prepared via the Schiff-base reaction under ambient conditions.	Benzo(a)pyrene	125-127	poly(A) binding protein cytoplasmic 3	Homo sapiens	42-48
34979192-0	2022	Aspirin ameliorates the cognition impairment in mice following benzo(a)pyrene treatment via down-regulating BDNF IV methylation.	Benzo(a)pyrene	63-77	brain derived neurotrophic factor	Mus musculus	108-112
34979192-10	2022	Aspirin co-treatment rescued DNMTs activation and BDNF IV hypermethylation, and mitigated the recession in BDNF mRNA and protein induced by B(a)P treatment.	Benzo(a)pyrene	140-145	brain derived neurotrophic factor	Mus musculus	50-54
34979192-10	2022	Aspirin co-treatment rescued DNMTs activation and BDNF IV hypermethylation, and mitigated the recession in BDNF mRNA and protein induced by B(a)P treatment.	Benzo(a)pyrene	140-145	brain derived neurotrophic factor	Mus musculus	107-111
34979192-12	2022	These findings reveal a critical role of BDNF IV methylation in the neurotoxicity of B(a)P, and demonstrate a promising prevention of aspirin against B(a)P-induced cognitive impairment via inhibiting BDNF IV hypermethylation.	Benzo(a)pyrene	85-90	brain derived neurotrophic factor	Mus musculus	41-45
34607190-4	2021	Acute exposure of zebrafish larvae to BaP from 3 to 6 days post-fertilization (dpf) induced a dose-dependent reduction of the opercular bone size and a depletion of osteocalcin-positive cells, indicating an effect on osteoblast maturation.	Benzo(a)pyrene	38-41	bone gamma-carboxyglutamate (gla) protein	Danio rerio	165-176
34903147-7	2022	The S. purpurea L extract increased CAT activity and GSH levels accompanied by a decrease in MDA levels after treatment with B(a)P and CP.	Benzo(a)pyrene	125-130	catalase	Mus musculus	36-39
34944003-6	2021	Kynurenine (Kyn), formylindolo(3,4-b) carbazole (FICZ), and benzopyrene (BaP), which are AhR agonists, inhibited osteoclast formation and Kyn suppressed osteoclast differentiation at an early stage.	Benzo(a)pyrene	73-76	aryl hydrocarbon receptor	Homo sapiens	89-92
34329126-0	2021	Integration of data from the cell-based ERK1/2 ELISA and the Comparative Toxicogenomics Database deciphers the potential mode of action of bisphenol A and benzo(a)pyrene in lung neoplasm.	Benzo(a)pyrene	155-169	mitogen-activated protein kinase 3	Homo sapiens	40-46
34329126-4	2021	A549 cells were exposed to bisphenol A (BPA), benzo(a)pyrene (BaP), tributyltin (TBT), and ibuprofen from 10-12 M to 10-5 M. Results show that BPA, BaP, and TBT can activate ERK1/2 in A549 cells.	Benzo(a)pyrene	46-60	mitogen-activated protein kinase 3	Homo sapiens	174-180
34329126-4	2021	A549 cells were exposed to bisphenol A (BPA), benzo(a)pyrene (BaP), tributyltin (TBT), and ibuprofen from 10-12 M to 10-5 M. Results show that BPA, BaP, and TBT can activate ERK1/2 in A549 cells.	Benzo(a)pyrene	62-65	mitogen-activated protein kinase 3	Homo sapiens	174-180
34329126-4	2021	A549 cells were exposed to bisphenol A (BPA), benzo(a)pyrene (BaP), tributyltin (TBT), and ibuprofen from 10-12 M to 10-5 M. Results show that BPA, BaP, and TBT can activate ERK1/2 in A549 cells.	Benzo(a)pyrene	148-151	mitogen-activated protein kinase 3	Homo sapiens	174-180
34329126-5	2021	We selected BPA and BaP to elucidate the molecular events connecting chemical exposure, ERK1/2 signaling, phenotypes, and lung neoplasm (LN) using CTD.	Benzo(a)pyrene	20-23	mitogen-activated protein kinase 3	Homo sapiens	88-94
34329126-6	2021	CTD analysis showed that BPA and BaP share 26 mitogen-activated protein kinase 1/3 (MAPK1/3) signaling genes associated with LN.	Benzo(a)pyrene	33-36	mitogen-activated protein kinase 13	Homo sapiens	46-82
34329126-6	2021	CTD analysis showed that BPA and BaP share 26 mitogen-activated protein kinase 1/3 (MAPK1/3) signaling genes associated with LN.	Benzo(a)pyrene	33-36	mitogen-activated protein kinase 13	Homo sapiens	84-91
34852300-7	2022	Besides, BP containing scaffolds exhibited higher content of CD31+ cells than that of the control scaffolds at 1 week after implantation in vivo.	Benzo(a)pyrene	9-11	platelet and endothelial cell adhesion molecule 1	Homo sapiens	61-65
34424081-9	2021	Conclusions: This suggests that BaP exposure can aggravate Dp-induced AD-like skin lesions through TH2-biased responses in the inflamed sites and the activation of regional lymph nodes.	Benzo(a)pyrene	32-35	heart and neural crest derivatives expressed 2	Mus musculus	99-102
34690024-8	2021	BaP-conditioned medium significantly increased DNA damage, p53 stabilization, AhR activation and POMC secretion in keratinocytes.	Benzo(a)pyrene	0-3	tumor protein p53	Homo sapiens	59-62
34838920-3	2022	To elucidate the potential role of Wnt5a-mediated non-canonical Wnt-YAP/TAZ signaling in the lung injury induced by short-term exposure of benzo(a)pyrene (BaP, a representative PAHs), intratracheally instilled mouse model was used and further interfered with its Wnt5a level by small molecule antagonists and agonists.	Benzo(a)pyrene	155-158	wingless-type MMTV integration site family, member 5A	Mus musculus	35-40
34838920-3	2022	To elucidate the potential role of Wnt5a-mediated non-canonical Wnt-YAP/TAZ signaling in the lung injury induced by short-term exposure of benzo(a)pyrene (BaP, a representative PAHs), intratracheally instilled mouse model was used and further interfered with its Wnt5a level by small molecule antagonists and agonists.	Benzo(a)pyrene	155-158	yes-associated protein 1	Mus musculus	68-71
34838920-3	2022	To elucidate the potential role of Wnt5a-mediated non-canonical Wnt-YAP/TAZ signaling in the lung injury induced by short-term exposure of benzo(a)pyrene (BaP, a representative PAHs), intratracheally instilled mouse model was used and further interfered with its Wnt5a level by small molecule antagonists and agonists.	Benzo(a)pyrene	155-158	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	72-75
34838920-3	2022	To elucidate the potential role of Wnt5a-mediated non-canonical Wnt-YAP/TAZ signaling in the lung injury induced by short-term exposure of benzo(a)pyrene (BaP, a representative PAHs), intratracheally instilled mouse model was used and further interfered with its Wnt5a level by small molecule antagonists and agonists.	Benzo(a)pyrene	155-158	wingless-type MMTV integration site family, member 5A	Mus musculus	263-268
34838920-4	2022	Our data revealed that BaP exposure induced the lung inflammatory response and reduced the expression of Clara cell secretory protein (CC16) in a dose-dependent manner.	Benzo(a)pyrene	23-26	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	105-133
34838920-4	2022	Our data revealed that BaP exposure induced the lung inflammatory response and reduced the expression of Clara cell secretory protein (CC16) in a dose-dependent manner.	Benzo(a)pyrene	23-26	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	135-139
34838920-6	2022	Functionally, inhibition of Wnt5a attenuated the BaP-induced inflammation and recuperated CC16 expression, as well as suppressed the epithelial cytokines release.	Benzo(a)pyrene	49-52	wingless-type MMTV integration site family, member 5A	Mus musculus	28-33
34838920-6	2022	Functionally, inhibition of Wnt5a attenuated the BaP-induced inflammation and recuperated CC16 expression, as well as suppressed the epithelial cytokines release.	Benzo(a)pyrene	49-52	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	90-94
34838920-8	2022	Our findings together suggest that Wnt5a is a potential endogenous regulator in lung inflammation and airway epithelial injury, and Wnt5a-YAP/TAZ signaling contributes to lung dysfunction in acute exposure to BaP.	Benzo(a)pyrene	209-212	wingless-type MMTV integration site family, member 5A	Mus musculus	35-40
34838920-8	2022	Our findings together suggest that Wnt5a is a potential endogenous regulator in lung inflammation and airway epithelial injury, and Wnt5a-YAP/TAZ signaling contributes to lung dysfunction in acute exposure to BaP.	Benzo(a)pyrene	209-212	wingless-type MMTV integration site family, member 5A	Mus musculus	132-137
34838920-8	2022	Our findings together suggest that Wnt5a is a potential endogenous regulator in lung inflammation and airway epithelial injury, and Wnt5a-YAP/TAZ signaling contributes to lung dysfunction in acute exposure to BaP.	Benzo(a)pyrene	209-212	yes-associated protein 1	Mus musculus	138-141
34838920-8	2022	Our findings together suggest that Wnt5a is a potential endogenous regulator in lung inflammation and airway epithelial injury, and Wnt5a-YAP/TAZ signaling contributes to lung dysfunction in acute exposure to BaP.	Benzo(a)pyrene	209-212	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	142-145
34947813-5	2021	Tobacco smoke and haze (smohaze) and the carcinogen benzo(a)pyrene induce the secretion of CXCL13 by lung epithelial cells, which contributes to environmental lung carcinogenesis.	Benzo(a)pyrene	52-66	chemokine (C-X-C motif) ligand 13	Mus musculus	91-97
34947813-6	2021	Interestingly, the knockout of CXCL13 inhibits benzo(a)pyrene-induced lung cancer and azoxymethane/dextran sodium sulfate-induced colorectal cancer in mice.	Benzo(a)pyrene	47-61	chemokine (C-X-C motif) ligand 13	Mus musculus	31-37
34666019-3	2021	The methodology presented good linearity r2 > 0.99, LOD of 0.9 and 0.7 ng mL-1 for BaA and BaP, respectively.	Benzo(a)pyrene	91-94	L1 cell adhesion molecule	Mus musculus	74-78
34543639-0	2021	Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA).	Benzo(a)pyrene	56-72	cytochrome c oxidase II, mitochondrial	Mus musculus	31-36
34543639-3	2021	The objective is to analyse the inflammatory changes and COX-2 gene expression in benzo (a) pyrene induced mice and to evaluate the regulatory effect of all trans retinoic acid.	Benzo(a)pyrene	82-98	cytochrome c oxidase II, mitochondrial	Mus musculus	57-62
34610339-0	2021	Malignant transformation of human bronchial epithelial cells induced by benzo (a) pyrene suggests a negative feedback of TP53 to PPP1R13L via binding a possible enhancer element.	Benzo(a)pyrene	72-88	tumor protein p53	Homo sapiens	121-125
34610339-0	2021	Malignant transformation of human bronchial epithelial cells induced by benzo (a) pyrene suggests a negative feedback of TP53 to PPP1R13L via binding a possible enhancer element.	Benzo(a)pyrene	72-88	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	129-137
34331502-8	2021	At week 5, both Ment doses reduced peripheral leukocyte blood genotoxicity 4 h after the last BaP administration, but only Ment50 attenuated this biomarker 8 h after the last BaP administration.	Benzo(a)pyrene	94-97	predicted gene 128	Mus musculus	16-20
34331502-9	2021	In accordance to these findings, both Ment interventions attenuated BaP-induced increase in the percentage of H2A.X-positive forestomach epithelial cells.	Benzo(a)pyrene	68-71	H2A.X variant histone	Mus musculus	110-115
34547448-5	2021	Mancozeb, benzo(a)pyrene, and bisphenol A stimulated ERK1/2 up to ~2- (HepG2) and 1.5 (RTL-W1)-fold, though the kinetics differed between chemicals and cell lines.	Benzo(a)pyrene	10-24	mitogen-activated protein kinase 3	Homo sapiens	53-59
34547448-6	2021	Bisphenol A and benzo(a)pyrene were the most potent concentration-wise, altering ERK1/2 activity in pM (HepG2) to nM (RTL-W1) range.	Benzo(a)pyrene	16-30	mitogen-activated protein kinase 3	Homo sapiens	81-87
34690024-8	2021	BaP-conditioned medium significantly increased DNA damage, p53 stabilization, AhR activation and POMC secretion in keratinocytes.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	78-81
34690024-8	2021	BaP-conditioned medium significantly increased DNA damage, p53 stabilization, AhR activation and POMC secretion in keratinocytes.	Benzo(a)pyrene	0-3	proopiomelanocortin	Homo sapiens	97-101
34690024-10	2021	Importantly, BaP-conditioned medium-induced DNA damage and POMC secretion is prevented by antioxidants vitamin E, vitamin C and sulforaphane, as well as the prototypical corticosteroid dexamethasone.	Benzo(a)pyrene	13-16	proopiomelanocortin	Homo sapiens	59-63
34426389-5	2021	A solubilization test manifested that PS and its major components (dipalmitoyl phosphatidylcholine, DPPC; bovine serum albumin, BSA) could in turn accelerate the dissolution of BaP, which followed the order: PS > DPPC > BSA, and mixed phospholipids were significantly responsible for the solubilization of BaP by PS.	Benzo(a)pyrene	177-180	albumin	Homo sapiens	113-126
34426389-5	2021	A solubilization test manifested that PS and its major components (dipalmitoyl phosphatidylcholine, DPPC; bovine serum albumin, BSA) could in turn accelerate the dissolution of BaP, which followed the order: PS > DPPC > BSA, and mixed phospholipids were significantly responsible for the solubilization of BaP by PS.	Benzo(a)pyrene	306-309	albumin	Homo sapiens	113-126
34437932-3	2021	Our study aimed to detect the effect of dendritic cell vaccine loaded with tumor cell lysate (TCL-DCV) on percentage of CD166+ CSC in lung of mice exposed to Benzo(a)Pyrene (BP).	Benzo(a)pyrene	158-172	activated leukocyte cell adhesion molecule	Mus musculus	120-125
34437932-3	2021	Our study aimed to detect the effect of dendritic cell vaccine loaded with tumor cell lysate (TCL-DCV) on percentage of CD166+ CSC in lung of mice exposed to Benzo(a)Pyrene (BP).	Benzo(a)pyrene	174-176	activated leukocyte cell adhesion molecule	Mus musculus	120-125
34454013-0	2021	DNA adduct formation and reduced EIF4A3expression contributes to Benzo(a)pyrene-induced DNA damage in human bronchial epithelial BEAS-2B cells.	Benzo(a)pyrene	65-79	eukaryotic translation initiation factor 4A3	Homo sapiens	33-39
34597721-0	2021	AHR/ROS-mediated mitochondria apoptosis contributes to benzo(a)pyrene-induced heart defects and the protective effects of resveratrol.	Benzo(a)pyrene	55-69	aryl hydrocarbon receptor 1a	Danio rerio	0-3
34597721-8	2021	In conclusion, our findings show that BaP induces oxidative stress via AHR activation, which causes mitochondria-mediated intrinsic apoptosis, resulting in heart malformations in zebrafish embryos, and that RSV had a protective effect against BaP-induced heart defects mainly by inhibiting oxidative stress rather than through antagonism of AHR activity.	Benzo(a)pyrene	38-41	aryl hydrocarbon receptor 1a	Danio rerio	71-74
34597721-3	2021	Here, we found that BaP increased heart malformations in zebrafish embryos in a concentration-dependent manner, which were attenuated by supplementation with either CH223191 (CH), an aryl hydrocarbon receptor (AHR) inhibitor, or N-acetyl-l-cysteine (NAC), a reactive oxygen species (ROS) scavenger.	Benzo(a)pyrene	20-23	aryl hydrocarbon receptor 1a	Danio rerio	183-208
34597721-3	2021	Here, we found that BaP increased heart malformations in zebrafish embryos in a concentration-dependent manner, which were attenuated by supplementation with either CH223191 (CH), an aryl hydrocarbon receptor (AHR) inhibitor, or N-acetyl-l-cysteine (NAC), a reactive oxygen species (ROS) scavenger.	Benzo(a)pyrene	20-23	aryl hydrocarbon receptor 1a	Danio rerio	210-213
34472326-6	2021	Using samples displaying Cyp1a1 induction, we observed significantly higher metabolic affinity for BaP metabolism (Km reduced 3-fold), 3-fold higher intrinsic clearance, but no changes to the Vmax.	Benzo(a)pyrene	99-102	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	25-31
34332006-1	2021	BACKGROUND: Previous work indicated that benzo(a)pyrene (B(a)P) exposure in utero might adversely affect neurodevelopment and cause Parkinson"s Disease (PD)-like symptoms.	Benzo(a)pyrene	41-55	prohibitin 2	Mus musculus	57-62
34473432-6	2021	RESULTS: We found that the expression of S1PR3 was also into the nucleus of lung cells in vitro, data that were confirmed in lung tissues of NSCLC patients, smoking and tumor bearing BaP-exposed mice.	Benzo(a)pyrene	183-186	sphingosine-1-phosphate receptor 3	Homo sapiens	41-46
34242566-1	2021	Benzo(a)pyrene (BaP) is a strong carcinogen for lung cancer, and forkhead-box A1 (FOXA1) plays an oncogenic role in BaP-transformed cell THBEc1.	Benzo(a)pyrene	0-14	forkhead box A1	Homo sapiens	65-80
34216713-7	2021	Our results showed that 5-DMNB had a substantial inhibitory effect on CYP1B1 induced by BaP and upregulated the detoxification enzymes UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs).	Benzo(a)pyrene	88-91	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	70-76
34216713-9	2021	Exposure to BaP/DSS also significantly elevated TNF-alpha levels, and the administration of 5-DMNB reversed this increase.	Benzo(a)pyrene	12-15	tumor necrosis factor	Mus musculus	48-57
34242566-1	2021	Benzo(a)pyrene (BaP) is a strong carcinogen for lung cancer, and forkhead-box A1 (FOXA1) plays an oncogenic role in BaP-transformed cell THBEc1.	Benzo(a)pyrene	0-14	forkhead box A1	Homo sapiens	82-87
34242566-1	2021	Benzo(a)pyrene (BaP) is a strong carcinogen for lung cancer, and forkhead-box A1 (FOXA1) plays an oncogenic role in BaP-transformed cell THBEc1.	Benzo(a)pyrene	16-19	forkhead box A1	Homo sapiens	65-80
34242566-2	2021	To explore the remodeling of metabolic pattern caused by BaP-induced transformation and the possible role FOXA1 might play in it, we compared metabolic patterns between THBEc1 cells and control using untargeted metabolomics and lipidomics analysis, and determined the effects of FOXA1 knockout on the metabolic pattern of THBEc1 cells.	Benzo(a)pyrene	57-60	forkhead box A1	Homo sapiens	106-111
34242566-8	2021	In conclusion, FOXA1 knockout partially reversed the remodeling of glucose metabolism caused by BaP-induced malignant transformation.	Benzo(a)pyrene	96-99	forkhead box A1	Homo sapiens	15-20
34497759-3	2021	This study found that EGR1 was significantly downregulated during human bronchial epithelial cell transformation and mice lung carcinogenesis upon exposure to B(a)P and its active form BPDE, respectively.	Benzo(a)pyrene	159-164	early growth response 1	Homo sapiens	22-26
34450627-0	2021	Benzo(a)pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades.	Benzo(a)pyrene	0-14	microRNA 650	Homo sapiens	26-33
34450627-0	2021	Benzo(a)pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades.	Benzo(a)pyrene	0-14	suppressor of cytokine signaling 3	Homo sapiens	129-134
34450627-0	2021	Benzo(a)pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades.	Benzo(a)pyrene	0-14	signal transducer and activator of transcription 3	Homo sapiens	139-144
34451048-8	2021	The proposed system is valid and practically useful for applications of BP assessment in the field, especially when measuring abrupt changes in BR.	Benzo(a)pyrene	72-74	chromosome 12 open reading frame 73	Homo sapiens	144-146
34439562-6	2021	Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively.	Benzo(a)pyrene	239-244	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-50
34439562-6	2021	Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively.	Benzo(a)pyrene	239-244	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	52-58
34439562-6	2021	Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively.	Benzo(a)pyrene	239-244	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113
34439562-6	2021	Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively.	Benzo(a)pyrene	239-244	aryl hydrocarbon receptor	Homo sapiens	155-180
34439562-6	2021	Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively.	Benzo(a)pyrene	239-244	aryl hydrocarbon receptor	Homo sapiens	182-185
34488261-14	2021	When DBP and BaP exposed together, NF-kappaB p65 protein expression level was positively correlated with CXCL-13, IL-6, TNF-alpha, ALT and AST (r=0.711, 0.764, 0.955, 0.903 and 0.827, P<0.05) .	Benzo(a)pyrene	13-16	C-X-C motif chemokine ligand 13	Rattus norvegicus	105-112
34488261-5	2021	Results: The protein expression of NF-kappaB p65 in BaP(1) group was not statistically significant, but the mRNA and protein expression levels of NF-kappaB p65 in the liver tissues of rats in other exposure group were higher than those in the blank control group (P<0.05) , and the expression levels of NF-kappaB p65 increased more obvious in the DBP and BaP co-exposed groups than those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	355-358	Brca1 associated protein 1	Rattus norvegicus	52-58
34488261-6	2021	The serum levels of CXCL-13 and IL-6 of rats in other group were obviously higher than those of the blank control group except for the BaP(1) group, and the increase was more obvious in the high-dose group that co-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	233-236	C-X-C motif chemokine ligand 13	Rattus norvegicus	20-27
34488261-14	2021	When DBP and BaP exposed together, NF-kappaB p65 protein expression level was positively correlated with CXCL-13, IL-6, TNF-alpha, ALT and AST (r=0.711, 0.764, 0.955, 0.903 and 0.827, P<0.05) .	Benzo(a)pyrene	13-16	interleukin 6	Rattus norvegicus	114-118
34488261-6	2021	The serum levels of CXCL-13 and IL-6 of rats in other group were obviously higher than those of the blank control group except for the BaP(1) group, and the increase was more obvious in the high-dose group that co-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	233-236	interleukin 6	Rattus norvegicus	32-36
34488261-6	2021	The serum levels of CXCL-13 and IL-6 of rats in other group were obviously higher than those of the blank control group except for the BaP(1) group, and the increase was more obvious in the high-dose group that co-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	233-236	Brca1 associated protein 1	Rattus norvegicus	135-141
34488261-14	2021	When DBP and BaP exposed together, NF-kappaB p65 protein expression level was positively correlated with CXCL-13, IL-6, TNF-alpha, ALT and AST (r=0.711, 0.764, 0.955, 0.903 and 0.827, P<0.05) .	Benzo(a)pyrene	13-16	tumor necrosis factor	Rattus norvegicus	120-129
34488261-14	2021	When DBP and BaP exposed together, NF-kappaB p65 protein expression level was positively correlated with CXCL-13, IL-6, TNF-alpha, ALT and AST (r=0.711, 0.764, 0.955, 0.903 and 0.827, P<0.05) .	Benzo(a)pyrene	13-16	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	139-142
34488261-15	2021	In addition, Pearson correlation analysis showed a positive correlation between TNF-alpha and ALT (r=0.833 and 0.894, P<0.05) when DBP or BaP exposed alone.	Benzo(a)pyrene	138-141	tumor necrosis factor	Rattus norvegicus	80-89
34488261-16	2021	Furthermore, when DBP and BaP exposed together, CXCL-13, IL-6 and TNF-alpha were positively correlated with ALT (r= 0.871, 0.925 and 0.942, P<0.05) , and also positively correlated with AST (r=0.910, 0.892 and 0.890, P<0.05) .	Benzo(a)pyrene	26-29	C-X-C motif chemokine ligand 13	Rattus norvegicus	48-55
34488261-16	2021	Furthermore, when DBP and BaP exposed together, CXCL-13, IL-6 and TNF-alpha were positively correlated with ALT (r= 0.871, 0.925 and 0.942, P<0.05) , and also positively correlated with AST (r=0.910, 0.892 and 0.890, P<0.05) .	Benzo(a)pyrene	26-29	interleukin 6	Rattus norvegicus	57-61
34488261-16	2021	Furthermore, when DBP and BaP exposed together, CXCL-13, IL-6 and TNF-alpha were positively correlated with ALT (r= 0.871, 0.925 and 0.942, P<0.05) , and also positively correlated with AST (r=0.910, 0.892 and 0.890, P<0.05) .	Benzo(a)pyrene	26-29	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	186-189
34459573-0	2021	Benzo(a)pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts.	Benzo(a)pyrene	0-14	gonadotropin releasing hormone 1	Homo sapiens	54-84
34439523-0	2021	Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo(a)pyrene via ROS/NF-kappaB/NLRP3/Caspase-1 Signaling Pathway.	Benzo(a)pyrene	67-81	nuclear factor kappa B subunit 1	Homo sapiens	90-99
34439523-0	2021	Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo(a)pyrene via ROS/NF-kappaB/NLRP3/Caspase-1 Signaling Pathway.	Benzo(a)pyrene	67-81	NLR family pyrin domain containing 3	Homo sapiens	100-105
34439523-0	2021	Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo(a)pyrene via ROS/NF-kappaB/NLRP3/Caspase-1 Signaling Pathway.	Benzo(a)pyrene	67-81	caspase 1	Homo sapiens	106-115
34413168-5	2021	Cytotoxic drugs, crude tobacco products, benzo(a)pyrene, nicotine, and multiple other toxic compounds were shown to exhibit rapid PD-L1/PD-1 upregulation.	Benzo(a)pyrene	41-55	CD274 molecule	Homo sapiens	130-135
34413168-5	2021	Cytotoxic drugs, crude tobacco products, benzo(a)pyrene, nicotine, and multiple other toxic compounds were shown to exhibit rapid PD-L1/PD-1 upregulation.	Benzo(a)pyrene	41-55	programmed cell death 1	Homo sapiens	136-140
34354438-9	2021	The results evidenced that BaP induced mice decreased the bodyweight, increased lung weight, increased tumor markers (AHH, CEA and LDH), and increased the proinflammatory cytokines.	Benzo(a)pyrene	27-30	carcinoembryonic antigen gene family	Mus musculus	123-126
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Benzo(a)pyrene	73-76	BCL2, apoptosis regulator	Rattus norvegicus	21-26
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Benzo(a)pyrene	73-76	interleukin 6	Rattus norvegicus	28-32
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Benzo(a)pyrene	73-76	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	34-39
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Benzo(a)pyrene	73-76	catenin beta 1	Rattus norvegicus	41-53
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Benzo(a)pyrene	73-76	nitric oxide synthase 2	Rattus norvegicus	58-62
34360828-1	2021	The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase.	Benzo(a)pyrene	28-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-166
34360828-1	2021	The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase.	Benzo(a)pyrene	28-42	epoxide hydrolase 1	Homo sapiens	181-209
34360828-1	2021	The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase.	Benzo(a)pyrene	44-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-166
34360828-1	2021	The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase.	Benzo(a)pyrene	44-47	epoxide hydrolase 1	Homo sapiens	181-209
34360828-8	2021	Thus, BaP genotoxicity in rats in vivo appears to be related to the enhanced expression and/or activity of hepatic CYP1A1/2 and 1B1 caused by exposure of rats to the studied compounds.	Benzo(a)pyrene	6-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	115-131
34158118-8	2021	The frequency of gpt point mutations significantly increased in the liver and bone marrow of N-nitroso-N-ethylurea (ENU)- and benzo(a)pyrene (BaP)-treated rats.	Benzo(a)pyrene	126-140	glutamic--pyruvic transaminase	Rattus norvegicus	17-20
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	144-147	tumor necrosis factor	Rattus norvegicus	19-28
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	144-147	tumor necrosis factor	Rattus norvegicus	119-128
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	271-274	tumor necrosis factor	Rattus norvegicus	19-28
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	271-274	tumor necrosis factor	Rattus norvegicus	119-128
34488261-9	2021	Except for the BaP(1) group, the levels of AST in other exposed groups were increased (P<0.05) , and the levels of ALT and AST in the DBP and BaP co-exposed groups were significantly elevated in comparison to the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	269-272	Brca1 associated protein 1	Rattus norvegicus	15-21
34488261-9	2021	Except for the BaP(1) group, the levels of AST in other exposed groups were increased (P<0.05) , and the levels of ALT and AST in the DBP and BaP co-exposed groups were significantly elevated in comparison to the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	269-272	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	43-46
34488261-9	2021	Except for the BaP(1) group, the levels of AST in other exposed groups were increased (P<0.05) , and the levels of ALT and AST in the DBP and BaP co-exposed groups were significantly elevated in comparison to the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	269-272	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	123-126
34488261-10	2021	On the contrary, the level of ALB in each exposure group was significantly lower than that in the blank control group, especially decreased significantly in the DBP and BaP co-exposed group (P<0.05) .	Benzo(a)pyrene	169-172	albumin	Rattus norvegicus	30-33
34488261-13	2021	After BaP exposed alone, the NF-kappaB p65 protein expression level was positively correlated with TNF-alpha and ALT (r=0.911 and 0.910, P<0.05) .	Benzo(a)pyrene	6-9	tumor necrosis factor	Rattus norvegicus	99-108
34290363-5	2021	In particular, whether benzo(a)pyrene (B(a)P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles.	Benzo(a)pyrene	23-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-127
34290363-5	2021	In particular, whether benzo(a)pyrene (B(a)P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles.	Benzo(a)pyrene	39-44	aryl-hydrocarbon receptor	Mus musculus	104-107
34290363-5	2021	In particular, whether benzo(a)pyrene (B(a)P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles.	Benzo(a)pyrene	39-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-127
34283317-3	2021	The purpose of the present study was to investigate the effects of a known toxic agent, benzo(a)pyrene (BaP), on the regulation and interaction between GJIC and Wnt/beta-catenin signaling.	Benzo(a)pyrene	88-102	catenin beta 1	Rattus norvegicus	165-177
34283317-3	2021	The purpose of the present study was to investigate the effects of a known toxic agent, benzo(a)pyrene (BaP), on the regulation and interaction between GJIC and Wnt/beta-catenin signaling.	Benzo(a)pyrene	104-107	catenin beta 1	Rattus norvegicus	165-177
34283317-4	2021	BaP treatment resulted in GJIC inhibition and decreases the major GJIC protein connexin 43 (Cx43) in WB-F344 rat liver epithelial cells.	Benzo(a)pyrene	0-3	gap junction protein, alpha 1	Rattus norvegicus	79-90
34283317-4	2021	BaP treatment resulted in GJIC inhibition and decreases the major GJIC protein connexin 43 (Cx43) in WB-F344 rat liver epithelial cells.	Benzo(a)pyrene	0-3	gap junction protein, alpha 1	Rattus norvegicus	92-96
34283317-5	2021	We also found BaP-mediated downregulation of Wnt/beta-catenin signaling related to the PI3K-Akt pathway.	Benzo(a)pyrene	14-17	catenin beta 1	Rattus norvegicus	49-61
34283317-5	2021	We also found BaP-mediated downregulation of Wnt/beta-catenin signaling related to the PI3K-Akt pathway.	Benzo(a)pyrene	14-17	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
34283317-8	2021	Despite the inverse correlation between Wnt/beta-catenin signaling and Cx43 promoter activation as indicated by downregulation of beta-catenin nuclear translocation and upregulation of Cx43 promoter activation involving HNF3beta, BaP treatment decreased the Cx43 protein expression, which was associated with protein degradation, possibly through protein kinase C activation.	Benzo(a)pyrene	230-233	catenin beta 1	Rattus norvegicus	44-56
34283317-8	2021	Despite the inverse correlation between Wnt/beta-catenin signaling and Cx43 promoter activation as indicated by downregulation of beta-catenin nuclear translocation and upregulation of Cx43 promoter activation involving HNF3beta, BaP treatment decreased the Cx43 protein expression, which was associated with protein degradation, possibly through protein kinase C activation.	Benzo(a)pyrene	230-233	gap junction protein, alpha 1	Rattus norvegicus	71-75
34283317-8	2021	Despite the inverse correlation between Wnt/beta-catenin signaling and Cx43 promoter activation as indicated by downregulation of beta-catenin nuclear translocation and upregulation of Cx43 promoter activation involving HNF3beta, BaP treatment decreased the Cx43 protein expression, which was associated with protein degradation, possibly through protein kinase C activation.	Benzo(a)pyrene	230-233	gap junction protein, alpha 1	Rattus norvegicus	185-189
34283317-8	2021	Despite the inverse correlation between Wnt/beta-catenin signaling and Cx43 promoter activation as indicated by downregulation of beta-catenin nuclear translocation and upregulation of Cx43 promoter activation involving HNF3beta, BaP treatment decreased the Cx43 protein expression, which was associated with protein degradation, possibly through protein kinase C activation.	Benzo(a)pyrene	230-233	forkhead box A1	Rattus norvegicus	220-228
34283317-8	2021	Despite the inverse correlation between Wnt/beta-catenin signaling and Cx43 promoter activation as indicated by downregulation of beta-catenin nuclear translocation and upregulation of Cx43 promoter activation involving HNF3beta, BaP treatment decreased the Cx43 protein expression, which was associated with protein degradation, possibly through protein kinase C activation.	Benzo(a)pyrene	230-233	gap junction protein, alpha 1	Rattus norvegicus	258-262
34283317-9	2021	In conclusion, our results revealed the mechanism of BaP-induced inhibition of GJIC and Wnt/beta-catenin signaling.	Benzo(a)pyrene	53-56	catenin beta 1	Rattus norvegicus	92-104
34180219-3	2021	Relying on the specific recognition between the vicinal diol compound and boronic acid, a novel alizarin red S (ARS)-borono-peptide (BP) spherical nanoindicator was fabricated, accompanying with the emission of strong fluorescent signal.	Benzo(a)pyrene	133-135	secreted LY6/PLAUR domain containing 1	Homo sapiens	96-110
34180219-3	2021	Relying on the specific recognition between the vicinal diol compound and boronic acid, a novel alizarin red S (ARS)-borono-peptide (BP) spherical nanoindicator was fabricated, accompanying with the emission of strong fluorescent signal.	Benzo(a)pyrene	133-135	secreted LY6/PLAUR domain containing 1	Homo sapiens	112-115
34184213-12	2022	Although BP showed greater apoptosis-inducing capacity, we observed that both DPD (6 mM) and BP (24 mM) treatment showed anti-leukemic effect by triggering apoptotic pathway through increasing Bax/Bcl-2 ratio for the first time.	Benzo(a)pyrene	9-11	BCL2 associated X, apoptosis regulator	Homo sapiens	193-196
34184213-12	2022	Although BP showed greater apoptosis-inducing capacity, we observed that both DPD (6 mM) and BP (24 mM) treatment showed anti-leukemic effect by triggering apoptotic pathway through increasing Bax/Bcl-2 ratio for the first time.	Benzo(a)pyrene	9-11	BCL2 apoptosis regulator	Homo sapiens	197-202
34184213-12	2022	Although BP showed greater apoptosis-inducing capacity, we observed that both DPD (6 mM) and BP (24 mM) treatment showed anti-leukemic effect by triggering apoptotic pathway through increasing Bax/Bcl-2 ratio for the first time.	Benzo(a)pyrene	93-95	BCL2 associated X, apoptosis regulator	Homo sapiens	193-196
34184213-12	2022	Although BP showed greater apoptosis-inducing capacity, we observed that both DPD (6 mM) and BP (24 mM) treatment showed anti-leukemic effect by triggering apoptotic pathway through increasing Bax/Bcl-2 ratio for the first time.	Benzo(a)pyrene	93-95	BCL2 apoptosis regulator	Homo sapiens	197-202
34158118-8	2021	The frequency of gpt point mutations significantly increased in the liver and bone marrow of N-nitroso-N-ethylurea (ENU)- and benzo(a)pyrene (BaP)-treated rats.	Benzo(a)pyrene	142-145	glutamic--pyruvic transaminase	Rattus norvegicus	17-20
34199731-10	2021	The mRNA levels of beta-defensin-2 and -3 were significantly upregulated in the buccal mucosa of the BP group.	Benzo(a)pyrene	101-103	defensin beta 2	Mus musculus	19-41
34199736-0	2021	Daytime Restricted Feeding Modifies the Temporal Expression of CYP1A1 and Attenuated Damage Induced by Benzo(a)pyrene in Rat Liver When Administered before CYP1A1 Acrophase.	Benzo(a)pyrene	103-117	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	63-69
34122006-8	2021	A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression was high in the BP group, while Tryptophan hydroxylase 1(TpH1)/5-hydroxytryptamine (5-HT) only changed in the combined group.	Benzo(a)pyrene	157-159	indoleamine 2,3-dioxygenase 1	Homo sapiens	47-74
34122006-8	2021	A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression was high in the BP group, while Tryptophan hydroxylase 1(TpH1)/5-hydroxytryptamine (5-HT) only changed in the combined group.	Benzo(a)pyrene	157-159	indoleamine 2,3-dioxygenase 1	Homo sapiens	76-79
34122006-8	2021	A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression was high in the BP group, while Tryptophan hydroxylase 1(TpH1)/5-hydroxytryptamine (5-HT) only changed in the combined group.	Benzo(a)pyrene	157-159	aryl hydrocarbon receptor	Homo sapiens	98-123
34122006-8	2021	A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression was high in the BP group, while Tryptophan hydroxylase 1(TpH1)/5-hydroxytryptamine (5-HT) only changed in the combined group.	Benzo(a)pyrene	157-159	aryl hydrocarbon receptor	Homo sapiens	125-128
34122006-8	2021	A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression was high in the BP group, while Tryptophan hydroxylase 1(TpH1)/5-hydroxytryptamine (5-HT) only changed in the combined group.	Benzo(a)pyrene	157-159	tryptophan hydroxylase 1	Homo sapiens	198-202
34065697-0	2021	Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways.	Benzo(a)pyrene	37-51	aryl hydrocarbon receptor	Homo sapiens	118-121
34065697-0	2021	Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways.	Benzo(a)pyrene	37-51	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
34141168-8	2021	Also, B(a)P induced DNA damage as well as activated an apoptotic pathway confirmed by upregulation of Bax, caspase-3, and downregulation of Bcl-2 expression.	Benzo(a)pyrene	6-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	102-105
34141168-8	2021	Also, B(a)P induced DNA damage as well as activated an apoptotic pathway confirmed by upregulation of Bax, caspase-3, and downregulation of Bcl-2 expression.	Benzo(a)pyrene	6-11	caspase 3	Rattus norvegicus	107-116
34141168-8	2021	Also, B(a)P induced DNA damage as well as activated an apoptotic pathway confirmed by upregulation of Bax, caspase-3, and downregulation of Bcl-2 expression.	Benzo(a)pyrene	6-11	BCL2, apoptosis regulator	Rattus norvegicus	140-145
34486357-12	2021	Oral administration of MP-SeNPs, on the other hand, increased the levels of SOD, GPx, TNF-alpha, iNOs and GSH as well as decreased the level of MDA in mammal tissue of BaP-treated rats.	Benzo(a)pyrene	168-171	superoxide dismutase 1	Homo sapiens	76-79
34486357-12	2021	Oral administration of MP-SeNPs, on the other hand, increased the levels of SOD, GPx, TNF-alpha, iNOs and GSH as well as decreased the level of MDA in mammal tissue of BaP-treated rats.	Benzo(a)pyrene	168-171	tumor necrosis factor	Homo sapiens	86-95
34486357-12	2021	Oral administration of MP-SeNPs, on the other hand, increased the levels of SOD, GPx, TNF-alpha, iNOs and GSH as well as decreased the level of MDA in mammal tissue of BaP-treated rats.	Benzo(a)pyrene	168-171	nitric oxide synthase 2	Homo sapiens	97-101
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	216-230	aryl hydrocarbon receptor	Rattus norvegicus	4-29
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	216-230	aryl hydrocarbon receptor	Rattus norvegicus	31-34
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	216-230	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	109-133
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	216-230	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	135-139
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	216-230	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	153-159
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	232-235	aryl hydrocarbon receptor	Rattus norvegicus	4-29
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	232-235	aryl hydrocarbon receptor	Rattus norvegicus	31-34
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	232-235	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	109-133
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	232-235	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	135-139
34199736-1	2021	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP).	Benzo(a)pyrene	232-235	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	153-159
34199736-8	2021	Although a high CYP1A1 expression has been previously associated with BaP genotoxicity, our results show that, compared with the ALF group, DRF attenuated the BaP-CYP1A1 induction potency, the liver DNA-BaP adducts, the liver concentration of unmetabolized BaP, and the blood aspartate aminotransferase and alanine aminotransferase activities when BaP is administered prior to the acrophase of CYP1A1 expression.	Benzo(a)pyrene	348-351	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	16-22
34199736-8	2021	Although a high CYP1A1 expression has been previously associated with BaP genotoxicity, our results show that, compared with the ALF group, DRF attenuated the BaP-CYP1A1 induction potency, the liver DNA-BaP adducts, the liver concentration of unmetabolized BaP, and the blood aspartate aminotransferase and alanine aminotransferase activities when BaP is administered prior to the acrophase of CYP1A1 expression.	Benzo(a)pyrene	348-351	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	163-169
35427736-0	2022	Benzo(a)pyrene inhibits myoblast differentiation through downregulating the Hsp70-K2-p38MAPK complex.	Benzo(a)pyrene	0-14	heat shock protein family A (Hsp70) member 4	Homo sapiens	76-81
35427736-0	2022	Benzo(a)pyrene inhibits myoblast differentiation through downregulating the Hsp70-K2-p38MAPK complex.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 14	Homo sapiens	85-92
35427736-2	2022	Benzo(a)pyrene (BaP), one major constituent that is inhaled during smoking, is particularly known for its ability to impair neurodevelopment, impede reproductivity, or reduce birth weight.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
35579750-10	2022	Mechanistically, we found that BP downregulated ALKBH5 expression, which in turn repressed m6A demethylation of MLST8 and EIF4EBP1 mRNAs.	Benzo(a)pyrene	31-33	alkB homolog 5, RNA demethylase	Homo sapiens	48-54
35579750-10	2022	Mechanistically, we found that BP downregulated ALKBH5 expression, which in turn repressed m6A demethylation of MLST8 and EIF4EBP1 mRNAs.	Benzo(a)pyrene	31-33	MTOR associated protein, LST8 homolog	Homo sapiens	112-117
35579750-10	2022	Mechanistically, we found that BP downregulated ALKBH5 expression, which in turn repressed m6A demethylation of MLST8 and EIF4EBP1 mRNAs.	Benzo(a)pyrene	31-33	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	122-130
35579750-13	2022	CONCLUSIONS: Our data indicate that BP can inhibit acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNAs, which may have potential to prevent and treat this disease.	Benzo(a)pyrene	36-38	alkB homolog 5, RNA demethylase	Homo sapiens	111-117
35579750-13	2022	CONCLUSIONS: Our data indicate that BP can inhibit acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNAs, which may have potential to prevent and treat this disease.	Benzo(a)pyrene	36-38	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	148-156
35579750-13	2022	CONCLUSIONS: Our data indicate that BP can inhibit acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNAs, which may have potential to prevent and treat this disease.	Benzo(a)pyrene	36-38	MTOR associated protein, LST8 homolog	Homo sapiens	161-166
35561843-6	2022	Mechanistic studies revealed that BaP induced low Sirt1 expression and high miR-34a-5p expression, and puerarin treatment alleviated these changes.	Benzo(a)pyrene	34-37	sirtuin 1	Homo sapiens	50-55
35561843-10	2022	Collectively, miR-34a-5p participates in the regulation of puerarin"s protective function against BaP-induced injury through targeting Sirt1.	Benzo(a)pyrene	98-101	sirtuin 1	Homo sapiens	135-140
35358593-10	2022	Compound BP and EP enhanced the SOD and CAT activity, reduced the ROS and lipid peroxidation level, thus decreasing cell death in zebrafish larvae.	Benzo(a)pyrene	9-11	catalase	Danio rerio	40-43
35624854-12	2022	Moreover, tomentosin inhibited the AhR signaling pathway, as evidenced by the suppression of xenobiotic-response element (XRE) reporter activity and the translocation of AhR into nucleus induced by urban pollutants, especially benzo(a)pyrene.	Benzo(a)pyrene	227-241	aryl hydrocarbon receptor	Homo sapiens	35-38
35624854-12	2022	Moreover, tomentosin inhibited the AhR signaling pathway, as evidenced by the suppression of xenobiotic-response element (XRE) reporter activity and the translocation of AhR into nucleus induced by urban pollutants, especially benzo(a)pyrene.	Benzo(a)pyrene	227-241	aryl hydrocarbon receptor	Homo sapiens	170-173
35567930-0	2022	Benzo(a)pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	62-87
35567930-1	2022	BACKGROUND: Benzo(a)pyrene (BaP), a toxic carcinogen, is associated with various adverse effects but is rarely discussed in muscle-related disorders.	Benzo(a)pyrene	12-26	prohibitin 2	Mus musculus	28-31
35114457-3	2022	In this study, root exudates" effect on the source-sink dynamics of benzo(a)pyrene (BaP) in a simulated wetland sediment system was investigated, and the identification results of labile, stable-adsorbed, and bound-residue fraction highlighted that root exudates" priming effects could accelerate fraction transformation and depuration of BaP in wetlands.	Benzo(a)pyrene	68-82	prohibitin 2	Homo sapiens	84-87
35315151-11	2022	When exposed to pollution stress by treating the models with benzo(a)pyrene and airborne particulate matter (PM10), application of both formulations prior to exposure attenuated the induction of CYP1A1, CYP1B1 and UGT1A7 expression, indicating a protective effect.	Benzo(a)pyrene	61-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	195-201
34711124-7	2022	Moreover, micronuclei formation along with protein expression of bcl-2 showed significant increase in the lungs of BP treated rats.	Benzo(a)pyrene	115-117	BCL2, apoptosis regulator	Rattus norvegicus	65-70
34711124-9	2022	Also, the combined treatment regulated the protein expressions of bcl-2 in BP-treated rats.	Benzo(a)pyrene	75-77	BCL2, apoptosis regulator	Rattus norvegicus	66-71
35473600-7	2022	RESULTS: BaP can enhance the binding ability of HIF-1alpha protein to HIF-1beta/ARNT in a dose-dependent manner without CoCl2.	Benzo(a)pyrene	9-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
35473600-7	2022	RESULTS: BaP can enhance the binding ability of HIF-1alpha protein to HIF-1beta/ARNT in a dose-dependent manner without CoCl2.	Benzo(a)pyrene	9-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-79
35473600-7	2022	RESULTS: BaP can enhance the binding ability of HIF-1alpha protein to HIF-1beta/ARNT in a dose-dependent manner without CoCl2.	Benzo(a)pyrene	9-12	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	80-84
35437857-6	2022	BaP treatment showed significantly increased in the activities of Phase I biotransformation enzymes (Cytochrome P450 , b5 , and aryl hydrocarbon hydrolase) and inhibited the activity of Phase II enzyme (glutathione-S-transferase).	Benzo(a)pyrene	0-3	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	101-121
35437857-6	2022	BaP treatment showed significantly increased in the activities of Phase I biotransformation enzymes (Cytochrome P450 , b5 , and aryl hydrocarbon hydrolase) and inhibited the activity of Phase II enzyme (glutathione-S-transferase).	Benzo(a)pyrene	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	203-228
35437857-11	2022	Moreover, levels of tumor biomarkers such as total sialic acid, carcinoembryonic antigen, and alkaline phosphatase were significantly elevated following BaP treatment which was substantiated by alterations noticed in the histoarchitecture of lung tissue.	Benzo(a)pyrene	153-156	CEA cell adhesion molecule 20	Rattus norvegicus	64-88
35315151-11	2022	When exposed to pollution stress by treating the models with benzo(a)pyrene and airborne particulate matter (PM10), application of both formulations prior to exposure attenuated the induction of CYP1A1, CYP1B1 and UGT1A7 expression, indicating a protective effect.	Benzo(a)pyrene	61-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	203-209
35315151-11	2022	When exposed to pollution stress by treating the models with benzo(a)pyrene and airborne particulate matter (PM10), application of both formulations prior to exposure attenuated the induction of CYP1A1, CYP1B1 and UGT1A7 expression, indicating a protective effect.	Benzo(a)pyrene	61-75	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	214-220
35151814-6	2022	BaP induced hypomethylation of COX-2 and MSH2 in normal PBMCs and hypermethylation of APC in HCT116 CRC cells.	Benzo(a)pyrene	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
35151814-7	2022	BaP also non-significantly decreased global methylation levels in 3 cancer cell lines (HCT16, PC3, and A549), as measured by ELISA assay.	Benzo(a)pyrene	0-3	chromobox 8	Homo sapiens	94-97
34986425-0	2022	Exposure to benzo(a)pyrene suppresses mitophagy via ANT1-PINK1-Parkin pathway in ovarian corpus luteum during early pregnancy.	Benzo(a)pyrene	12-26	solute carrier family 25 member 4	Homo sapiens	52-56
34986425-0	2022	Exposure to benzo(a)pyrene suppresses mitophagy via ANT1-PINK1-Parkin pathway in ovarian corpus luteum during early pregnancy.	Benzo(a)pyrene	12-26	PTEN induced kinase 1	Homo sapiens	57-62
34986425-7	2022	We found that BaP and its metabolite, BPDE, inhibited autophagy and PINK1/Parkin-mediated mitophagy in the pregnant ovaries and luteinized granulosa cell, KGN.	Benzo(a)pyrene	14-17	PTEN induced kinase 1	Homo sapiens	68-73
34986425-8	2022	Notably, adenine nucleotide translocator 1 (ANT1), a crucial mediator of PINK1-dependent mitophagy, was suppressed by BaP and BPDE both in vivo and in vitro.	Benzo(a)pyrene	118-121	solute carrier family 25 member 4	Homo sapiens	9-42
34986425-8	2022	Notably, adenine nucleotide translocator 1 (ANT1), a crucial mediator of PINK1-dependent mitophagy, was suppressed by BaP and BPDE both in vivo and in vitro.	Benzo(a)pyrene	118-121	solute carrier family 25 member 4	Homo sapiens	44-48
34986425-8	2022	Notably, adenine nucleotide translocator 1 (ANT1), a crucial mediator of PINK1-dependent mitophagy, was suppressed by BaP and BPDE both in vivo and in vitro.	Benzo(a)pyrene	118-121	PTEN induced kinase 1	Homo sapiens	73-78
34986425-12	2022	Collectively, our study firstly clarified that BaP and BPDE suppress mitophagy of CL cells via the ANT1-PINK1-Parkin pathway, which provides a new insight to explore the detailed mechanism of the BaP-induced ovarian toxicity.	Benzo(a)pyrene	47-50	solute carrier family 25 member 4	Homo sapiens	99-103
34986425-12	2022	Collectively, our study firstly clarified that BaP and BPDE suppress mitophagy of CL cells via the ANT1-PINK1-Parkin pathway, which provides a new insight to explore the detailed mechanism of the BaP-induced ovarian toxicity.	Benzo(a)pyrene	47-50	PTEN induced kinase 1	Homo sapiens	104-109
34986425-12	2022	Collectively, our study firstly clarified that BaP and BPDE suppress mitophagy of CL cells via the ANT1-PINK1-Parkin pathway, which provides a new insight to explore the detailed mechanism of the BaP-induced ovarian toxicity.	Benzo(a)pyrene	196-199	solute carrier family 25 member 4	Homo sapiens	99-103
34986425-12	2022	Collectively, our study firstly clarified that BaP and BPDE suppress mitophagy of CL cells via the ANT1-PINK1-Parkin pathway, which provides a new insight to explore the detailed mechanism of the BaP-induced ovarian toxicity.	Benzo(a)pyrene	196-199	PTEN induced kinase 1	Homo sapiens	104-109
35392295-9	2022	The expression of mitochondrial biosynthesis genes of liver, cecum, and muscle showed that AM treatment increased gene expression of CPT1b compared to the BP treatment.	Benzo(a)pyrene	155-157	LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, muscle isoform	Oryctolagus cuniculus	133-138
35065163-7	2022	The highest amount of COX-2, the most increased activity of CYP1A1 and cPLA2, and overexpression of GSTM1, CYP1A1, ICAM-1, and VCAM-1 gene was observed in HUVEC cells treated with BaP.	Benzo(a)pyrene	180-183	prostaglandin-endoperoxide synthase 2	Homo sapiens	22-27
35065163-7	2022	The highest amount of COX-2, the most increased activity of CYP1A1 and cPLA2, and overexpression of GSTM1, CYP1A1, ICAM-1, and VCAM-1 gene was observed in HUVEC cells treated with BaP.	Benzo(a)pyrene	180-183	glutathione S-transferase mu 1	Homo sapiens	100-105
35065163-7	2022	The highest amount of COX-2, the most increased activity of CYP1A1 and cPLA2, and overexpression of GSTM1, CYP1A1, ICAM-1, and VCAM-1 gene was observed in HUVEC cells treated with BaP.	Benzo(a)pyrene	180-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-113
35065163-7	2022	The highest amount of COX-2, the most increased activity of CYP1A1 and cPLA2, and overexpression of GSTM1, CYP1A1, ICAM-1, and VCAM-1 gene was observed in HUVEC cells treated with BaP.	Benzo(a)pyrene	180-183	intercellular adhesion molecule 1	Homo sapiens	115-121
35065163-7	2022	The highest amount of COX-2, the most increased activity of CYP1A1 and cPLA2, and overexpression of GSTM1, CYP1A1, ICAM-1, and VCAM-1 gene was observed in HUVEC cells treated with BaP.	Benzo(a)pyrene	180-183	vascular cell adhesion molecule 1	Homo sapiens	127-133
35065163-8	2022	After co-treatment with BaP and ARA or EPA, an increase of GSTM1 level was observed.	Benzo(a)pyrene	24-27	glutathione S-transferase mu 1	Homo sapiens	59-64
35065163-9	2022	Incubation of endothelial cells with ARA or EPA and BaP resulted in lower CYP1A1 and cPLA2 activities and lower expression of VCAM-1 and ICAM-1 genes.	Benzo(a)pyrene	52-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
35065163-9	2022	Incubation of endothelial cells with ARA or EPA and BaP resulted in lower CYP1A1 and cPLA2 activities and lower expression of VCAM-1 and ICAM-1 genes.	Benzo(a)pyrene	52-55	phospholipase A2 group IVA	Homo sapiens	85-90
35065163-9	2022	Incubation of endothelial cells with ARA or EPA and BaP resulted in lower CYP1A1 and cPLA2 activities and lower expression of VCAM-1 and ICAM-1 genes.	Benzo(a)pyrene	52-55	vascular cell adhesion molecule 1	Homo sapiens	126-132
35065163-9	2022	Incubation of endothelial cells with ARA or EPA and BaP resulted in lower CYP1A1 and cPLA2 activities and lower expression of VCAM-1 and ICAM-1 genes.	Benzo(a)pyrene	52-55	intercellular adhesion molecule 1	Homo sapiens	137-143
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	aryl-hydrocarbon receptor	Mus musculus	30-33
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	glutathione S-transferase, mu 1	Mus musculus	35-40
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	42-48
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	prostaglandin-endoperoxide synthase 2	Mus musculus	50-55
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	phospholipase A2 group IVA	Homo sapiens	57-64
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	nitric oxide synthase 3, endothelial cell	Mus musculus	70-74
35277564-11	2022	The theoretical degradation rates of PAHs by ozone, which were calculated using a pseudo-first-order rate equation, suggested that the lifetimes of benzo(a)pyrene (BaP) decreased by 1 min from 2007 to 2016.	Benzo(a)pyrene	148-162	prohibitin 2	Homo sapiens	164-167
35311121-17	2022	In addition, CTD database analysis identified abrine, Benzo (A) Pyrene, bisphenol A, Soman, Sunitinib, Tetrachloroethylene, Valproic Acid as seven targeted therapy drugs that may be effective treatments for seven targeted therapeutics.	Benzo(a)pyrene	54-70	CTD	Homo sapiens	13-16
35144130-15	2022	In conclusion, GSDMD may regulate NLRP3 inflammasome through miR-223, which is involved in B(a)P induced inflammatory damage in A549 cells.	Benzo(a)pyrene	91-96	gasdermin D	Homo sapiens	15-20
35144130-15	2022	In conclusion, GSDMD may regulate NLRP3 inflammasome through miR-223, which is involved in B(a)P induced inflammatory damage in A549 cells.	Benzo(a)pyrene	91-96	NLR family pyrin domain containing 3	Homo sapiens	34-39
35144130-15	2022	In conclusion, GSDMD may regulate NLRP3 inflammasome through miR-223, which is involved in B(a)P induced inflammatory damage in A549 cells.	Benzo(a)pyrene	91-96	microRNA 223	Homo sapiens	61-68
35299664-6	2022	The muscle protein content of beta-hydroxyacyl (HAD) increased by 55 +- 58% in TP only, while both TP and BP increased the content of cytochrome c oxidase subunit IV (COXIV) by 72 +- 34%.	Benzo(a)pyrene	106-108	cytochrome c oxidase subunit 4I1	Homo sapiens	134-165
35299664-6	2022	The muscle protein content of beta-hydroxyacyl (HAD) increased by 55 +- 58% in TP only, while both TP and BP increased the content of cytochrome c oxidase subunit IV (COXIV) by 72 +- 34%.	Benzo(a)pyrene	106-108	cytochrome c oxidase subunit 4I1	Homo sapiens	167-172
35193440-0	2022	Alterations of DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells induced by benzo(a)pyrene.	Benzo(a)pyrene	122-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
35193440-0	2022	Alterations of DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells induced by benzo(a)pyrene.	Benzo(a)pyrene	122-136	glutathione S-transferase pi 1	Homo sapiens	58-63
35193440-0	2022	Alterations of DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells induced by benzo(a)pyrene.	Benzo(a)pyrene	122-136	glutathione S-transferase mu 1	Homo sapiens	69-74
35193440-6	2022	The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B(a)P treatment at all three doses.	Benzo(a)pyrene	93-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-25
35193440-6	2022	The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B(a)P treatment at all three doses.	Benzo(a)pyrene	93-98	glutathione S-transferase pi 1	Homo sapiens	27-32
35151814-6	2022	BaP induced hypomethylation of COX-2 and MSH2 in normal PBMCs and hypermethylation of APC in HCT116 CRC cells.	Benzo(a)pyrene	0-3	mutS homolog 2	Homo sapiens	41-45
35218527-5	2022	Here we describe a 3D trophectoderm differentiation protocol with the use of BAP (BMP4, A83-01, and PD173074) to generate hESC-derived trophectoderm spheroids (BAP-EB).	Benzo(a)pyrene	77-80	bone morphogenetic protein 4	Homo sapiens	82-86
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	Benzo(a)pyrene	76-90	interleukin 27	Mus musculus	42-47
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	Benzo(a)pyrene	76-90	interferon lambda 3	Mus musculus	52-58
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	Benzo(a)pyrene	76-90	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	Benzo(a)pyrene	76-90	NLR family, pyrin domain containing 3	Mus musculus	144-149
34999049-1	2022	AIM: Our previous work depicted that benzo(a)pyrene (BaP)-induced lung cancer associated pulmonary redox imbalance and inflammation were effectively regulated by the combinatorial treatment of IL-27 and IL-28B.	Benzo(a)pyrene	37-51	interleukin 27	Mus musculus	193-198
34999049-1	2022	AIM: Our previous work depicted that benzo(a)pyrene (BaP)-induced lung cancer associated pulmonary redox imbalance and inflammation were effectively regulated by the combinatorial treatment of IL-27 and IL-28B.	Benzo(a)pyrene	37-51	interferon lambda 3	Mus musculus	203-209
34999049-1	2022	AIM: Our previous work depicted that benzo(a)pyrene (BaP)-induced lung cancer associated pulmonary redox imbalance and inflammation were effectively regulated by the combinatorial treatment of IL-27 and IL-28B.	Benzo(a)pyrene	53-56	interleukin 27	Mus musculus	193-198
34999049-1	2022	AIM: Our previous work depicted that benzo(a)pyrene (BaP)-induced lung cancer associated pulmonary redox imbalance and inflammation were effectively regulated by the combinatorial treatment of IL-27 and IL-28B.	Benzo(a)pyrene	53-56	interferon lambda 3	Mus musculus	203-209
34999049-2	2022	So in continuation of that finding the present study was designed to reveal the inflammation regulating signaling network modulated by IL-27 and IL-28B treatment related to BaP-induced lung cancer.	Benzo(a)pyrene	173-176	interleukin 27	Mus musculus	135-140
34999049-2	2022	So in continuation of that finding the present study was designed to reveal the inflammation regulating signaling network modulated by IL-27 and IL-28B treatment related to BaP-induced lung cancer.	Benzo(a)pyrene	173-176	interferon lambda 3	Mus musculus	145-151
34999049-9	2022	In combination, it was successful in down-regulating the expression of p-ERK1/2 and in reducing the accumulation of mast cells in the lung tissue associated with BaP-induced lung carcinogenesis.	Benzo(a)pyrene	162-165	mitogen-activated protein kinase 3	Mus musculus	73-79
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	Benzo(a)pyrene	157-160	interleukin 27	Mus musculus	58-63
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	Benzo(a)pyrene	157-160	interferon lambda 3	Mus musculus	68-74
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	Benzo(a)pyrene	157-160	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	Benzo(a)pyrene	157-160	NLR family, pyrin domain containing 3	Mus musculus	130-135
35199223-1	2022	Benzo(a)pyrene (BaP) is a high molecular weight polycyclic aromatic hydrocarbon produced as a result of incomplete combustion of organic substances.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
35203386-0	2022	Aryl Hydrocarbon Receptor Activation by Benzo(a)pyrene Prevents Development of Septic Shock and Fatal Outcome in a Mouse Model of Systemic Salmonella enterica Infection.	Benzo(a)pyrene	40-54	aryl-hydrocarbon receptor	Mus musculus	0-25
35203386-1	2022	This study focused on immunomodulatory effects of aryl hydrocarbon receptor (AhR) activation through benzo(a)pyrene (BaP) during systemic bacterial infection.	Benzo(a)pyrene	101-115	aryl-hydrocarbon receptor	Mus musculus	50-75
35203386-1	2022	This study focused on immunomodulatory effects of aryl hydrocarbon receptor (AhR) activation through benzo(a)pyrene (BaP) during systemic bacterial infection.	Benzo(a)pyrene	117-120	aryl-hydrocarbon receptor	Mus musculus	50-75
35209168-1	2022	Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) primarily formed by burning of fossil fuels, wood and other organic materials.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
35131859-3	2022	We hypothesized that BP modified with poly-2-methyl-2-oxazoline (POZ) to inhibit protein entry would demonstrate reduced accumulation of AGE and serum proteins, mitigating SVD.	Benzo(a)pyrene	21-23	renin binding protein	Bos taurus	137-140
35131859-4	2022	In vitro studies of POZ-modified BP demonstrated reduced accumulation of serum albumin and AGE.	Benzo(a)pyrene	33-35	renin binding protein	Bos taurus	91-94
34998820-2	2022	BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes.	Benzo(a)pyrene	0-3	aryl-hydrocarbon receptor	Mus musculus	31-56
34998820-2	2022	BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes.	Benzo(a)pyrene	0-3	aryl-hydrocarbon receptor	Mus musculus	58-61
34998820-2	2022	BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes.	Benzo(a)pyrene	0-3	aryl-hydrocarbon receptor	Mus musculus	86-89
34998820-7	2022	BaP also suppressed colonic expression of inflammation-associated genes and plasma interleukin-6 secretion induced by DSS treatment.	Benzo(a)pyrene	0-3	interleukin 6	Mus musculus	83-96
35193440-6	2022	The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B(a)P treatment at all three doses.	Benzo(a)pyrene	93-98	glutathione S-transferase mu 1	Homo sapiens	38-43
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	peroxisome proliferator activated receptor alpha	Mus musculus	238-247
35057794-0	2022	Molecular mechanism of benzo (a) pyrene regulating lipid metabolism via aryl hydrocarbon receptor.	Benzo(a)pyrene	23-39	aryl-hydrocarbon receptor	Mus musculus	72-97
35057794-1	2022	BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	12-28	aryl-hydrocarbon receptor	Mus musculus	126-151
35057794-1	2022	BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	12-28	aryl-hydrocarbon receptor	Mus musculus	153-156
35057794-1	2022	BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	30-33	aryl-hydrocarbon receptor	Mus musculus	126-151
35057794-1	2022	BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	30-33	aryl-hydrocarbon receptor	Mus musculus	153-156
35057794-3	2022	This topic will verify whether BaP regulates lipid metabolism via AhR.	Benzo(a)pyrene	31-34	aryl-hydrocarbon receptor	Mus musculus	66-69
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	192-202
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	peroxisome proliferator activated receptor gamma	Mus musculus	204-213
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	fatty acid binding protein 4, adipocyte	Mus musculus	215-220
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	222-232
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	281-290
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	chemokine (C-C motif) ligand 2	Mus musculus	292-297
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	tumor necrosis factor	Mus musculus	303-312
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	aryl-hydrocarbon receptor	Mus musculus	327-330
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	192-202
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	peroxisome proliferator activated receptor gamma	Mus musculus	204-213
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	fatty acid binding protein 4, adipocyte	Mus musculus	215-220
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	222-232
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	peroxisome proliferator activated receptor alpha	Mus musculus	238-247
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	281-290
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	chemokine (C-C motif) ligand 2	Mus musculus	292-297
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	tumor necrosis factor	Mus musculus	303-312
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	aryl-hydrocarbon receptor	Mus musculus	327-330
35057794-11	2022	CONCLUSION: BaP inhibit fat synthesis and oxidation while inducing inflammation by activating AhR, leading to WAT dysfunction and causing metabolic complications.	Benzo(a)pyrene	12-15	aryl-hydrocarbon receptor	Mus musculus	94-97
35052622-11	2022	CYP1B1 plays a critical role in the metabolic activation of BP to DNA-reactive metabolites.	Benzo(a)pyrene	60-62	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	0-6
34734245-9	2022	Genes related to monocyte/macrophage recruitment and activity, prolactin family genes, and several keratin genes were among the most upregulated genes in the BaP-exposed ovaries.	Benzo(a)pyrene	158-161	prolactin	Mus musculus	63-72
35001578-9	2022	On the other hand oral administration of resveratrol elevated the SOD, GPx and GR gene expression in lung rats treated with B(a)P.	Benzo(a)pyrene	124-129	glutathione-disulfide reductase	Rattus norvegicus	79-81
2791199-0	1989	Relative contribution of various forms of cytochrome P450 to the metabolism of benzo[a]pyrene by human liver microsomes.	Benzo(a)pyrene	79-93	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	53-57
2515665-2	1989	Metabolism of 14C-labelled benzo[a]pyrene (-)trans-7,8-dihydrodiol to protein- and DNA-binding products in a reconstituted enzyme system proceeds 5 to 10 times faster with rabbit cytochrome P-450 LM4 than with LM2.	Benzo(a)pyrene	27-41	cytochrome P450 1A2	Oryctolagus cuniculus	179-199
2509067-0	1989	Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.	Benzo(a)pyrene	75-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-42
2477159-2	1989	(i) In BP/CFA sensitization, CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules, but not CD5, CD8, or CD45, were generated after culture with BP.	Benzo(a)pyrene	7-9	Cd4 molecule	Rattus norvegicus	29-32
2477159-2	1989	(i) In BP/CFA sensitization, CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules, but not CD5, CD8, or CD45, were generated after culture with BP.	Benzo(a)pyrene	7-9	Cd4 molecule	Rattus norvegicus	82-105
2477159-2	1989	(i) In BP/CFA sensitization, CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules, but not CD5, CD8, or CD45, were generated after culture with BP.	Benzo(a)pyrene	7-9	interleukin 2	Rattus norvegicus	111-114
2477159-2	1989	(i) In BP/CFA sensitization, CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules, but not CD5, CD8, or CD45, were generated after culture with BP.	Benzo(a)pyrene	196-198	Cd4 molecule	Rattus norvegicus	29-32
2477159-2	1989	(i) In BP/CFA sensitization, CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules, but not CD5, CD8, or CD45, were generated after culture with BP.	Benzo(a)pyrene	196-198	Cd4 molecule	Rattus norvegicus	82-105
2477159-4	1989	(ii) In the case of BP/IFA sensitization, CD4+ T cells showed no remarkable change of cell size or surface molecule expression after culture with BP and were weakly encephalitogenic in the recipients.	Benzo(a)pyrene	20-22	Cd4 molecule	Rattus norvegicus	42-45
2477159-5	1989	Vigorous proliferation of the cells induced by addition of recombinant IL2 to the culture with BP neither enhanced the encephalitogenicity nor produced CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules.	Benzo(a)pyrene	95-97	interleukin 2	Rattus norvegicus	71-74
2477159-5	1989	Vigorous proliferation of the cells induced by addition of recombinant IL2 to the culture with BP neither enhanced the encephalitogenicity nor produced CD4+ blastoid T cells showing marked upregulation of CD4, class I and II MHC, and IL2 receptor molecules.	Benzo(a)pyrene	95-97	Cd4 molecule	Rattus norvegicus	205-228
2799823-1	1989	m-Xylene (1 g/kg, i.p., 1 h) was shown to decrease aryl hydrocarbon hydroxylase (AHH) activity, a detoxification pathway for benzo[a]pyrene (BaP), in the rat lung.	Benzo(a)pyrene	141-144	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	51-79
2799823-1	1989	m-Xylene (1 g/kg, i.p., 1 h) was shown to decrease aryl hydrocarbon hydroxylase (AHH) activity, a detoxification pathway for benzo[a]pyrene (BaP), in the rat lung.	Benzo(a)pyrene	141-144	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	81-84
2791199-1	1989	A variety of cytochromes P450 have been implicated in the hepatic metabolism of benzo[a]pyrene (BP), including forms that are constitutively expressed and those that are highly inducible.	Benzo(a)pyrene	80-94	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-29
2791199-1	1989	A variety of cytochromes P450 have been implicated in the hepatic metabolism of benzo[a]pyrene (BP), including forms that are constitutively expressed and those that are highly inducible.	Benzo(a)pyrene	96-98	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-29
2791199-2	1989	In the present study the metabolism of BP to organic solvent-soluble derivatives by eight forms of cytochrome P450 isolated from rat liver and by a series of 11 human liver microsomal samples was investigated.	Benzo(a)pyrene	39-41	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	110-114
2791199-7	1989	Of six different antibodies to forms of rat liver P450 tested, only those to P450s MC1a (P450IA2), MC1b (P450IA1) and UT1 (P450IIA1) consistently inhibited BP metabolism.	Benzo(a)pyrene	156-158	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	50-54
2791199-7	1989	Of six different antibodies to forms of rat liver P450 tested, only those to P450s MC1a (P450IA2), MC1b (P450IA1) and UT1 (P450IIA1) consistently inhibited BP metabolism.	Benzo(a)pyrene	156-158	cytochrome P450, family 2, subfamily c, polypeptide 12	Rattus norvegicus	118-121
2791199-9	1989	An antibody to cytochrome P450 PB3a (P450IIB1) did, however, inhibit the formation of metabolites at the 4,5- and 9,10-positions of BP by microsomal fractions of livers from one individual who had been receiving the drug phenytoin.	Benzo(a)pyrene	132-134	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	26-30
2791199-10	1989	These data indicate that several forms of P450 in human liver are involved in the metabolism of BP and that both constitutively expressed as well as inducible forms are important in its disposition in man.	Benzo(a)pyrene	96-98	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	42-46
2552308-1	1989	In vitro, the photodynamic compound benzo[a]pyrene (BAP) generates singlet oxygen efficiently when irradiated in organic solvents.	Benzo(a)pyrene	36-50	prohibitin 2	Homo sapiens	52-55
2473889-6	1989	We conclude that the BRL 3A BP (rBP-30) is the major insulin-like growth factor binding protein in the rat CNS and may be the rat analog of hBP-31, the predominant BP in human CSF.	Benzo(a)pyrene	28-30	Blood pressure QTL 30	Rattus norvegicus	32-38
2473889-6	1989	We conclude that the BRL 3A BP (rBP-30) is the major insulin-like growth factor binding protein in the rat CNS and may be the rat analog of hBP-31, the predominant BP in human CSF.	Benzo(a)pyrene	28-30	BP31	Homo sapiens	140-146
2778258-1	1989	To study the dermal penetration of benzo[a]pyrene (BAP) in relation to other polycyclic aromatic hydrocarbons (PAHs), a complex mixture of PAHs was applied to the backs of CD-1 mice, and the dermal residence times of BAP and eleven other PAHs were determined using gas chromatography.	Benzo(a)pyrene	35-49	prohibitin 2	Mus musculus	51-54
2473889-6	1989	We conclude that the BRL 3A BP (rBP-30) is the major insulin-like growth factor binding protein in the rat CNS and may be the rat analog of hBP-31, the predominant BP in human CSF.	Benzo(a)pyrene	28-30	colony stimulating factor 2	Homo sapiens	176-179
2512389-9	1989	This study is a clear indication of the major role of P-450IA1 (P-450c) in human placenta and probably P-450IA2 (P-450d) in human liver in BP activation, while other isozymes also take part in the activation in rat liver.	Benzo(a)pyrene	139-141	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-71
2674444-1	1989	Evidence suggests that the tissue renin-angiotensin-aldosterone (RAA) systems play an important role in BP homeostasis, with the possible importance of the vascular RAA system in hypertension being of particular interest.	Benzo(a)pyrene	104-106	renin	Homo sapiens	34-39
2512389-1	1989	The involvement of cytochrome P-450 isozymes in the activation of benzo[a]pyrene (BP) by human placental and liver microsomes was studied in vitro using monoclonal antibodies (Mab) toward the major 3-methylcholanthrene (MC)-inducible and phenobarbital-inductible rat liver P-450 isozymes (Mab 1-7-1 and Mab 2-66-3, respectively).	Benzo(a)pyrene	66-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-35
2512389-1	1989	The involvement of cytochrome P-450 isozymes in the activation of benzo[a]pyrene (BP) by human placental and liver microsomes was studied in vitro using monoclonal antibodies (Mab) toward the major 3-methylcholanthrene (MC)-inducible and phenobarbital-inductible rat liver P-450 isozymes (Mab 1-7-1 and Mab 2-66-3, respectively).	Benzo(a)pyrene	82-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-35
2674444-6	1989	The reduction of BP by ACE inhibitors, even when plasma renin activity is not elevated, has not been explained by an action on a local system and previous research efforts have focused on demonstrating renin-like activity in extra-renal tissues.	Benzo(a)pyrene	17-19	angiotensin I converting enzyme	Homo sapiens	23-26
2505924-0	1989	Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene.	Benzo(a)pyrene	134-148	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	13-41
2505924-2	1989	AHH activity in 10T1/2 cells was measured before and after culturing in the presence of benzo[a]pyrene (B[a]P), and compared to the AHH activity found in carcinogen-transformed 10T1/2 cell lines treated similarly.	Benzo(a)pyrene	88-102	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-3
2505924-2	1989	AHH activity in 10T1/2 cells was measured before and after culturing in the presence of benzo[a]pyrene (B[a]P), and compared to the AHH activity found in carcinogen-transformed 10T1/2 cell lines treated similarly.	Benzo(a)pyrene	104-109	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-3
2485079-1	1989	Adoptive transfer of experimental allergic encephalomyelitis (EAE) is enhanced after in vitro culture of myelin basic protein (BP)-sensitized lymphoid cells with BP.	Benzo(a)pyrene	127-129	myelin basic protein	Rattus norvegicus	105-125
2706743-3	1989	The resultant cell line, designated MCL-1, was substantially more sensitive to the mutagenicity of dimethylnitrosamine and benzo[a]pyrene than the AHH-1 cell line and was found to have increased metabolism of benzo[a]pyrene to dihydrodiols.	Benzo(a)pyrene	123-137	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	36-41
2706743-3	1989	The resultant cell line, designated MCL-1, was substantially more sensitive to the mutagenicity of dimethylnitrosamine and benzo[a]pyrene than the AHH-1 cell line and was found to have increased metabolism of benzo[a]pyrene to dihydrodiols.	Benzo(a)pyrene	209-223	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	36-41
2702728-4	1989	The average level of binding in this experiment was 148 +/- 8 pmol BaP bound/1 mg DNA, which compares favorably to the 10-30 pmol BAP/1 mg DNA which is typical of mouse skin adducts in vivo.	Benzo(a)pyrene	67-70	Brca1 associated protein 1	Mus musculus	130-135
2495007-6	1989	In contrast, in the kidney cytochrome P-450 concentration was significantly increased to (145-170% of the control), along with a modest decrease in benzo[a]pyrene hydroxylation activity.	Benzo(a)pyrene	148-162	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	27-43
2498299-0	1989	Purification and properties of cytochrome P-450 generally acting as a catalyst on benzo[a]pyrene hydroxylation from liver microsomes of untreated rats.	Benzo(a)pyrene	82-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	31-47
2498299-1	1989	A form of cytochrome P-450 generally catalyzing benzo[a]pyrene (B[a]P) hydroxylation was purified from liver microsomes of untreated rats on the basis of the catalytic activity.	Benzo(a)pyrene	48-62	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	10-26
2492425-5	1989	The in vivo and in vitro effects of schistosomicidal drugs on the activity of AHH were investigated using benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	106-120	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	78-81
2492425-5	1989	The in vivo and in vitro effects of schistosomicidal drugs on the activity of AHH were investigated using benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	122-124	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	78-81
2597022-0	1989	The effects of benzo(a)pyrene, nicotine, and tobacco-specific N-nitrosamines on the generation of human lymphokine-activated killer cells.	Benzo(a)pyrene	15-29	interleukin 2	Homo sapiens	104-114
2844763-8	1988	The liver mitochondrial cytochrome P-450 hydroxylates vitamin D3 and 1 alpha-hydroxyvitamin D3 at position 25, but did not show any activity toward xenobiotics such as benzphetamine, 7-ethoxycoumarin, and benzo[a]pyrene.	Benzo(a)pyrene	205-219	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-40
2910537-5	1989	Nevertheless, these adduct conformations resemble those derived from the highly tumorigenic anti and the less active syn diasteromers of benzo[a]pyrene and benz[a]anthracene, thus providing one additional example to the previously observed correlations between adduct structure and biological activity.	Benzo(a)pyrene	137-151	synemin	Homo sapiens	117-120
2737182-5	1989	Induction of MPCE in the bone marrow by four other compounds--benzo(a)pyrene, 2-naphthylamine, mitomycin C, and vincristine--was also increased by pretreatment with erythropoietin.	Benzo(a)pyrene	62-76	erythropoietin	Mus musculus	165-179
2497301-2	1989	The results confirmed the strong SOS inducing activity of 2-aminoanthracene and benzo[a]pyrene with metabolic activation and N-methyl-N"-nitro-N-nitrosoguanidine, mitomycin C and 4-nitroquinoline-N-oxide without metabolic activation.	Benzo(a)pyrene	80-94	xylosyltransferase 2	Homo sapiens	33-36
2576817-1	1989	Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP).	Benzo(a)pyrene	201-215	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	163-191
2576817-1	1989	Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP).	Benzo(a)pyrene	201-215	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	193-196
2576817-1	1989	Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP).	Benzo(a)pyrene	217-220	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	163-191
2576817-1	1989	Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP).	Benzo(a)pyrene	217-220	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	193-196
2576817-7	1989	The high BaP-induced AHH activity found in heterozygous embryos of DBA dams is in agreement with the dominant mode of inheritance for high AHH inducibility.	Benzo(a)pyrene	9-12	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-24
2576817-7	1989	The high BaP-induced AHH activity found in heterozygous embryos of DBA dams is in agreement with the dominant mode of inheritance for high AHH inducibility.	Benzo(a)pyrene	9-12	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	139-142
2576817-10	1989	The AHH inducibility by BaP did not correlate quantitatively with the induced aberration rates.	Benzo(a)pyrene	24-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	4-7
3143724-4	1988	Since aryl hydrocarbon hydroxylase is the principle enzyme activity which converts benzo(a)pyrene to toxic hydroxylated forms, the regulation of cytochrome P-450IA1 expression, the gene encoding this enzyme activity in MCF-7 cells, was examined.	Benzo(a)pyrene	83-97	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	6-34
2462252-4	1988	The responses of all these lines and clones to BP, as followed by both cell proliferation and interleukin 2 secretion assays, were affected by Cop 1.	Benzo(a)pyrene	47-49	interleukin 2	Homo sapiens	94-107
2462252-4	1988	The responses of all these lines and clones to BP, as followed by both cell proliferation and interleukin 2 secretion assays, were affected by Cop 1.	Benzo(a)pyrene	47-49	COP1 E3 ubiquitin ligase	Homo sapiens	143-148
2462252-5	1988	For one line, a direct cross proliferation with Cop 1 was observed, whereas in the other seven lines and clones, Cop 1 specifically inhibited the responses to BP in a competitive dose-dependent manner.	Benzo(a)pyrene	159-161	COP1 E3 ubiquitin ligase	Homo sapiens	113-118
2462252-6	1988	The inhibition of the response to BP is specific to Cop 1, as D-Cop 1 and another random acidic polymer, poly(Tyr,Glu,Ala) (TGA), both of which were previously demonstrated to be ineffective in suppression of experimental allergic encephalomyelitis, did not inhibit the response to BP.	Benzo(a)pyrene	34-36	COP1 E3 ubiquitin ligase	Homo sapiens	52-57
2462252-6	1988	The inhibition of the response to BP is specific to Cop 1, as D-Cop 1 and another random acidic polymer, poly(Tyr,Glu,Ala) (TGA), both of which were previously demonstrated to be ineffective in suppression of experimental allergic encephalomyelitis, did not inhibit the response to BP.	Benzo(a)pyrene	34-36	COP1 E3 ubiquitin ligase	Homo sapiens	64-69
2462252-7	1988	Furthermore, Cop 1 specifically inhibited only the response of the T-cell lines and clones to BP.	Benzo(a)pyrene	94-96	COP1 E3 ubiquitin ligase	Homo sapiens	13-18
2462252-9	1988	These results suggest that Cop 1 may be effective in suppression of experimental allergic encephalomyelitis, not only because of the selective stimulation of suppressor T cells, as we have previously demonstrated, but also by specific inhibition of BP-specific effector T cells.	Benzo(a)pyrene	249-251	COP1 E3 ubiquitin ligase	Homo sapiens	27-32
2903442-1	1988	The molecular nature of mutations in 6-thioguanine-resistant hypoxanthine/guanine phosphoribosyl transferase (HGPRT)-deficient clones of an adult rat liver (ARL) epithelial cell line mutated by benzo[a]pyrene or aflatoxin B1 was studied.	Benzo(a)pyrene	194-208	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	61-108
2903442-1	1988	The molecular nature of mutations in 6-thioguanine-resistant hypoxanthine/guanine phosphoribosyl transferase (HGPRT)-deficient clones of an adult rat liver (ARL) epithelial cell line mutated by benzo[a]pyrene or aflatoxin B1 was studied.	Benzo(a)pyrene	194-208	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	110-115
3208889-0	1988	[Cytochrome P-450-dependent mechanisms of the biosynthesis of protein-conjugated benzo(a)pyrene antigens and their role in the development of a specific immune response to this carcinogen].	Benzo(a)pyrene	81-95	cytochrome P-450	Oryctolagus cuniculus	1-17
3208889-1	1988	There was studied the possibility of covalent binding to proteins of a carcinogenic compound benzo(a)pyrene in the system of cytochrome P-450 of the liver and the possibility of the development of the immune reaction to administration of the conjugated antigens obtained in such a way to animals.	Benzo(a)pyrene	93-107	cytochrome P-450	Oryctolagus cuniculus	125-141
3402044-5	1988	Benzo[a]pyrene (B[a]P) binds with moderate affinity to both the Ah receptor and 4-5S binding protein and induces AHH in both -4S and +4S rats.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Rattus norvegicus	64-75
3402044-5	1988	Benzo[a]pyrene (B[a]P) binds with moderate affinity to both the Ah receptor and 4-5S binding protein and induces AHH in both -4S and +4S rats.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	113-116
2977405-5	1988	These results suggest that the reduction in plasma renin activity is associated with the acute reduction in BP following PTRA.	Benzo(a)pyrene	108-110	renin	Homo sapiens	51-56
2837492-9	1988	Cytochromes P-450mt1 and P-450mt2 were able to metabolize xenobiotics like benzo(a)pyrene and dimethyl benzanthracene at rates only one-tenth with cytochrome P-450c.	Benzo(a)pyrene	75-89	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-33
2837492-9	1988	Cytochromes P-450mt1 and P-450mt2 were able to metabolize xenobiotics like benzo(a)pyrene and dimethyl benzanthracene at rates only one-tenth with cytochrome P-450c.	Benzo(a)pyrene	75-89	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	147-164
3415807-4	1988	Inasmuch as the increase in the BP was totally prevented by intraperitoneal injection of guanethidine (40 mg/day), hyperactivity of the sympathetic nervous system appears, at least in part, responsible for the BP elevation caused by the combination of ICV hypertonic NaCl and IV subpressor AII infusion.	Benzo(a)pyrene	32-34	angiotensinogen	Rattus norvegicus	290-293
3266252-3	1988	In a multiple linear (step-wise) regression analysis, body mass index, age, immunoreactive insulin two hours after glucose load and serum total cholesterol contributed directly to the BP value but the weekly ethanol intake did not.	Benzo(a)pyrene	184-186	insulin	Homo sapiens	91-98
3415236-1	1988	14C-labeled benzo[a]pyrene (BaP) was used as a model-compound for polycyclic aromatic hydrocarbons (PAH) in order to assess the effect of photolytic pretreatment on the subsequent fate of BaP in sewage sludge and soil test systems.	Benzo(a)pyrene	12-26	prohibitin 2	Homo sapiens	28-31
3185539-3	1988	Microsomal oxidation of P450 substrates aminopyrine and benz(a) pyrene is inhibited by the 1-naphtoxyalcanthiols studied.	Benzo(a)pyrene	56-70	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	24-28
2837229-12	1988	One-electron oxidation of BP by Mn(OAc)3 occurred exclusively at C-6 with predominant formation of 6-acetoxyBP and small amounts of BP quinones.	Benzo(a)pyrene	26-28	complement C6	Rattus norvegicus	65-68
3368925-2	1988	Following intratracheal administration of benzo[a]pyrene (BP), an increase in pulmonary GSH-Px activity, GSH content and lipid peroxidation was observed after 12 h. GSH-Px activity and GSH content returned to control values by 7 and 30 days, respectively, whereas lipid peroxidation in the lung remained significantly greater than the control value for up to 7 days of BP administration.	Benzo(a)pyrene	42-56	glutathione peroxidase 1	Rattus norvegicus	88-94
3172284-3	1988	The increases of microsomal cytochrome b5 and cytochrome P-450 contents were noticed at 1, 12 and 24 hr after NCO-650 and BP administration.	Benzo(a)pyrene	122-124	cytochrome b5 type A	Rattus norvegicus	28-41
3172284-3	1988	The increases of microsomal cytochrome b5 and cytochrome P-450 contents were noticed at 1, 12 and 24 hr after NCO-650 and BP administration.	Benzo(a)pyrene	122-124	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	46-62
2452382-1	1988	Forty myelin basic protein (BP)-reactive T-cell clones were isolated from a patient with multiple sclerosis and used to identify human T-cell recognition sites on the BP molecule.	Benzo(a)pyrene	28-30	myelin basic protein	Homo sapiens	6-26
2835829-9	1988	Studies which included benzo[a]pyrene (BaP) as a control xenobiotic known to demonstrate Ah dependence showed that the MLR of splenic lymphocytes from Ah-congenic mice was comparably suppressed following 40 microM DMBA exposure, whereas exposure to 40 microM BaP resulted in suppression of the MLR only in B6-Ah(b)Ah(d) splenocytes.	Benzo(a)pyrene	23-37	prohibitin 2	Mus musculus	39-42
3368925-2	1988	Following intratracheal administration of benzo[a]pyrene (BP), an increase in pulmonary GSH-Px activity, GSH content and lipid peroxidation was observed after 12 h. GSH-Px activity and GSH content returned to control values by 7 and 30 days, respectively, whereas lipid peroxidation in the lung remained significantly greater than the control value for up to 7 days of BP administration.	Benzo(a)pyrene	42-56	glutathione peroxidase 1	Rattus norvegicus	165-171
3368925-2	1988	Following intratracheal administration of benzo[a]pyrene (BP), an increase in pulmonary GSH-Px activity, GSH content and lipid peroxidation was observed after 12 h. GSH-Px activity and GSH content returned to control values by 7 and 30 days, respectively, whereas lipid peroxidation in the lung remained significantly greater than the control value for up to 7 days of BP administration.	Benzo(a)pyrene	58-60	glutathione peroxidase 1	Rattus norvegicus	88-94
3368925-2	1988	Following intratracheal administration of benzo[a]pyrene (BP), an increase in pulmonary GSH-Px activity, GSH content and lipid peroxidation was observed after 12 h. GSH-Px activity and GSH content returned to control values by 7 and 30 days, respectively, whereas lipid peroxidation in the lung remained significantly greater than the control value for up to 7 days of BP administration.	Benzo(a)pyrene	58-60	glutathione peroxidase 1	Rattus norvegicus	165-171
3368925-2	1988	Following intratracheal administration of benzo[a]pyrene (BP), an increase in pulmonary GSH-Px activity, GSH content and lipid peroxidation was observed after 12 h. GSH-Px activity and GSH content returned to control values by 7 and 30 days, respectively, whereas lipid peroxidation in the lung remained significantly greater than the control value for up to 7 days of BP administration.	Benzo(a)pyrene	369-371	glutathione peroxidase 1	Rattus norvegicus	165-171
3368925-4	1988	On administration of BP, a significant increase in the activities of SOD and GSH-Px was observed at 12 h. After 7 and 30 days, the activities of these antioxidant enzymes were comparable to their respective control group values.	Benzo(a)pyrene	21-23	glutathione peroxidase 1	Rattus norvegicus	77-83
3258554-2	1988	It was found that EGF-significantly (3-7-fold) enhanced the frequency of morphological transformation induced by N-ethyl-N-nitrosourea or benzo[a]pyrene if added to growth medium supplemented with a batch of serum which had a low ability to support transformation.	Benzo(a)pyrene	138-152	pro-epidermal growth factor	Mesocricetus auratus	18-21
3293833-1	1988	A model has been proposed for the induction of cytochrome P450c in liver by polycyclic hydrocarbons such as benzo(a)pyrene (BaP) and 3-methylcholanthrene (3MC).	Benzo(a)pyrene	108-122	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	47-63
3293833-1	1988	A model has been proposed for the induction of cytochrome P450c in liver by polycyclic hydrocarbons such as benzo(a)pyrene (BaP) and 3-methylcholanthrene (3MC).	Benzo(a)pyrene	124-127	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	47-63
2837519-1	1988	The kinetics of benzo[a]pyrene (BaP) bioactivation by rat liver S9 fraction was characterized on the basis of inhibition of influenza virus induction of interferon-alpha/beta (IFN-alpha/beta) in mammalian LLC-MK2 cell cultures.	Benzo(a)pyrene	16-30	interferon alpha 1	Homo sapiens	176-179
2837519-1	1988	The kinetics of benzo[a]pyrene (BaP) bioactivation by rat liver S9 fraction was characterized on the basis of inhibition of influenza virus induction of interferon-alpha/beta (IFN-alpha/beta) in mammalian LLC-MK2 cell cultures.	Benzo(a)pyrene	32-35	interferon alpha 1	Homo sapiens	176-179
2837519-2	1988	Both viral IFN induction and production phases were sensitive to the adverse effects of bioactivated BaP.	Benzo(a)pyrene	101-104	interferon alpha 1	Homo sapiens	11-14
2837519-4	1988	When preceded by the analog, benzo[e]pyrene (BeP), the inhibitive action of bioactivated BaP on IFN induction was abrogated.	Benzo(a)pyrene	89-92	interferon alpha 1	Homo sapiens	96-99
2837519-6	1988	In cells pretreated with bioactivated BaP, influenza virus multiplication reached a level that was more than twofold higher than in normal cells which was a reflection of decreased IFN production.	Benzo(a)pyrene	38-41	interferon alpha 1	Homo sapiens	181-184
2837519-8	1988	BaP was selectively cyto-antagonistic to critical inducer-processing phases of IFN induction.	Benzo(a)pyrene	0-3	interferon alpha 1	Homo sapiens	79-82
2837519-9	1988	Of 32 different mammalian cell cultures tested for indigenous metabolizing enzyme-bioactivation of BaP, based on approximately equal to 50% resultant inhibition of IFN induction, only 37.5% were responsive.	Benzo(a)pyrene	99-102	interferon alpha 1	Homo sapiens	164-167
3276678-7	1988	The products of these reactions were identified by 500 MHz nmr and electron impact mass spectrometry as adducts of the 1,2-quinone of naphthalene (m/e M+ = 234) and the 7,8-quinone of benzo[a]pyrene (m/e M+ = 358), which contained mercaptoethanol as a thioether at C-4 and C-10, respectively.	Benzo(a)pyrene	184-198	complement C4A	Rattus norvegicus	265-268
2894240-2	1988	ABA exhibited an enhancing effect on the induction of GGT-positive foci by benzo[a]pyrene, but no effects on induction by a methylating agent, N-methyl-N-nitrosourea, in both rat strains.	Benzo(a)pyrene	75-89	gamma-glutamyltransferase 1	Rattus norvegicus	54-57
3335003-8	1988	The addition of anti-cytochrome P-448 antibody or the cofactors for UDP glucuronyl transferase and glutathione-S-transferase to the liver S-9 preincubation mixture with BP caused a marked decrease in BP mutagenicity when liver S-9 fractions from Sudan III-treated rats were used.	Benzo(a)pyrene	169-171	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-37
3335003-8	1988	The addition of anti-cytochrome P-448 antibody or the cofactors for UDP glucuronyl transferase and glutathione-S-transferase to the liver S-9 preincubation mixture with BP caused a marked decrease in BP mutagenicity when liver S-9 fractions from Sudan III-treated rats were used.	Benzo(a)pyrene	169-171	hematopoietic prostaglandin D synthase	Rattus norvegicus	99-124
3335003-8	1988	The addition of anti-cytochrome P-448 antibody or the cofactors for UDP glucuronyl transferase and glutathione-S-transferase to the liver S-9 preincubation mixture with BP caused a marked decrease in BP mutagenicity when liver S-9 fractions from Sudan III-treated rats were used.	Benzo(a)pyrene	200-202	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-37
3335003-8	1988	The addition of anti-cytochrome P-448 antibody or the cofactors for UDP glucuronyl transferase and glutathione-S-transferase to the liver S-9 preincubation mixture with BP caused a marked decrease in BP mutagenicity when liver S-9 fractions from Sudan III-treated rats were used.	Benzo(a)pyrene	200-202	hematopoietic prostaglandin D synthase	Rattus norvegicus	99-124
3334876-3	1988	In a reconstituted system, consisting of cytochrome P-450, NADPH-cytochrome-P-450 reductase and dilauroylphosphatidylcholine, cytochrome P-45017 alpha,lyase catalyzed, in addition to steroid hydroxylation, benzo[a]pyrene hydroxylation, but cytochrome P-450C21 did not hydroxylate benzo[a]pyrene.	Benzo(a)pyrene	206-220	NADPH--cytochrome P450 reductase	Cavia porcellus	59-91
3334876-3	1988	In a reconstituted system, consisting of cytochrome P-450, NADPH-cytochrome-P-450 reductase and dilauroylphosphatidylcholine, cytochrome P-45017 alpha,lyase catalyzed, in addition to steroid hydroxylation, benzo[a]pyrene hydroxylation, but cytochrome P-450C21 did not hydroxylate benzo[a]pyrene.	Benzo(a)pyrene	280-294	NADPH--cytochrome P450 reductase	Cavia porcellus	59-91
3335509-2	1988	Hepatic mitoplasts from 3-methylcholanthrene-treated rats contain cytochrome P-450 which can metabolize polycyclic aromatic hydrocarbons like benzo(a)pyrene.	Benzo(a)pyrene	142-156	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
3142693-2	1988	The aim was to examine factors that might be of importance for the tumorigenicity of BP in the regenerating rat liver, such as cytochrome P-450 activity and glutathione levels.	Benzo(a)pyrene	85-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	127-143
3142693-14	1988	Furthermore, MC, an inducer of certain cytochrome P-450 species ("aryl hydrocarbon hydroxylase"), potentiates the effect of BP.	Benzo(a)pyrene	124-126	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	39-55
2971711-8	1988	The data show that BP disrupts the maternal T cell repertoire, leading to an accumulation of Lyt 1-2+ cells, and suggest that splenic disruption may be due to changes in the differentiation potential of T precursor cells.	Benzo(a)pyrene	19-21	CD5 antigen	Mus musculus	93-98
3131261-0	1988	Inhibition of IL-2 responsiveness following exposure to benzo(a)pyrene is due to alterations in accessory cell function.	Benzo(a)pyrene	56-70	interleukin 2	Mus musculus	14-18
3131261-1	1988	The capacity of lymphocytes from C57Bl/6 X C3H/HeN F1 (B6C3F1) mice to proliferate in vitro following exposure to benzo(a)pyrene (BaP) in vivo or in vitro was examined.	Benzo(a)pyrene	114-128	prohibitin 2	Mus musculus	130-133
3181598-10	1988	Benzo(a)pyrene increased hepatic microsomal cytochrome P-450 content in rats on normal and selenium supplemented diet but not in the selenium deficient group.	Benzo(a)pyrene	0-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
3181598-12	1988	The 7-ethoxyresorufin and 7-ethoxycoumarin deethylase, aryl hydrocarbon hydroxylase and cytochrome c-reductase activities were increased by benzo(a)pyrene in all the dietary groups.	Benzo(a)pyrene	140-154	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	55-83
3350835-7	1988	These results indicate that chloro or bromo substitution at C-6 in BP reduces or eliminates carcinogenic activity.	Benzo(a)pyrene	67-69	complement component 6	Mus musculus	60-63
3120356-7	1987	The results suggest that (a) the CBP is not a tissue-specific protein in the mouse, (b) the ligands for the CBP are not limited to the unmetabolized procarcinogens but include both positively and negatively charged ligands, and (c) in vitro the CBP covalently binds the ultimate carcinogenic metabolite of benzo[a]pyrene.	Benzo(a)pyrene	306-320	CREB binding protein	Mus musculus	33-36
3120356-7	1987	The results suggest that (a) the CBP is not a tissue-specific protein in the mouse, (b) the ligands for the CBP are not limited to the unmetabolized procarcinogens but include both positively and negatively charged ligands, and (c) in vitro the CBP covalently binds the ultimate carcinogenic metabolite of benzo[a]pyrene.	Benzo(a)pyrene	306-320	CREB binding protein	Mus musculus	108-111
3120356-7	1987	The results suggest that (a) the CBP is not a tissue-specific protein in the mouse, (b) the ligands for the CBP are not limited to the unmetabolized procarcinogens but include both positively and negatively charged ligands, and (c) in vitro the CBP covalently binds the ultimate carcinogenic metabolite of benzo[a]pyrene.	Benzo(a)pyrene	306-320	CREB binding protein	Mus musculus	108-111
2444627-5	1987	In BP/CFA-sensitized cells, the expression of both W3/25 and OX-3 antigens on T cells increased markedly after culture with BP, but the expression of neither OX-19 nor OX-8 antigen increased significantly.	Benzo(a)pyrene	3-5	Cd4 molecule	Rattus norvegicus	51-65
2444627-5	1987	In BP/CFA-sensitized cells, the expression of both W3/25 and OX-3 antigens on T cells increased markedly after culture with BP, but the expression of neither OX-19 nor OX-8 antigen increased significantly.	Benzo(a)pyrene	124-126	Cd4 molecule	Rattus norvegicus	51-65
2444627-7	1987	Therefore, the generation of T cells coexpressing large amounts of both W3/25 and OX-3 antigens after culture with BP seems to correspond to the acquisition of the strong encephalitogenicity in vivo.	Benzo(a)pyrene	115-117	Cd4 molecule	Rattus norvegicus	72-86
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	Benzo(a)pyrene	110-124	prohibitin 2	Mus musculus	187-190
3657961-8	1987	We report here that the circular dichroism (CD) spectrum of a synthetic 54-bp deoxyoligonucleotide corresponding to the TFIIIA binding site is similar to the CD spectrum of B-form DNA in solution.	Benzo(a)pyrene	75-77	general transcription factor 3A L homeolog	Xenopus laevis	120-126
3040233-0	1987	Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.	Benzo(a)pyrene	156-170	aryl hydrocarbon receptor	Homo sapiens	0-11
3304665-8	1987	The amount of tartrate-resistant acid phosphatase activity in homogenates of the osteocalcin-deficient bone particle specimens not only lagged behind controls but never reached the maximum activity of control BP specimens.	Benzo(a)pyrene	209-211	bone gamma-carboxyglutamate protein	Homo sapiens	81-92
3041206-0	1987	Repair of benzo[a]pyrene-initiated DNA damage in human cells requires activation of DNA polymerase alpha.	Benzo(a)pyrene	10-24	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	84-104
3684951-7	1987	With human lymphocytes the method has proven to be a good indicator of "aryl hydrocarbon hydroxylase" (AHH) activity, correlating well with AHH assays using benzo(alpha)pyrene (BP) as a substrate.	Benzo(a)pyrene	177-179	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-100
3037886-1	1987	The renin-angiotensin-aldosterone system plays an integral role in the control of BP and is mediated by enzymatic transformation of substances in the renin-angiotensin cascade.	Benzo(a)pyrene	82-84	renin	Homo sapiens	4-9
3037886-1	1987	The renin-angiotensin-aldosterone system plays an integral role in the control of BP and is mediated by enzymatic transformation of substances in the renin-angiotensin cascade.	Benzo(a)pyrene	82-84	renin	Homo sapiens	150-155
3037891-8	1987	Angiotensin II plays an important role in preserving systemic BP and in preserving the glomerular filtration rate as renal artery pressure and renal blood flow decline; in addition, by stimulating the synthesis of aldosterone, the renin-angiotensin system provides an important role for potassium disposal.	Benzo(a)pyrene	62-64	angiotensinogen	Homo sapiens	0-14
2956999-4	1987	It is suggested that enhanced ANF secretion can be attributed to increased ANF demand in BP elevation, changes in the renal function in hypertensive subjects or genetic defect in the excretory renal function in SHR.	Benzo(a)pyrene	89-91	natriuretic peptide A	Rattus norvegicus	30-33
2956999-4	1987	It is suggested that enhanced ANF secretion can be attributed to increased ANF demand in BP elevation, changes in the renal function in hypertensive subjects or genetic defect in the excretory renal function in SHR.	Benzo(a)pyrene	89-91	natriuretic peptide A	Rattus norvegicus	75-78
3110592-0	1987	Regioselectivity of rat liver microsomal UDP-glucuronosyltransferase activities toward phenols of benzo(a)pyrene and dibenz(a,h)anthracene.	Benzo(a)pyrene	98-112	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	41-68
3660849-10	1987	Both ethoxyresorufin and benzo[a]pyrene inhibited the development of the type I optical difference spectrum of dihydrosafrole in reconstituted systems containing cytochrome P-450c.	Benzo(a)pyrene	25-39	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	162-179
3660849-16	1987	The results indicate that ethoxyresorufin and benzo[a]pyrene may occupy different binding sites on cytochrome P-450c and that dihydrosafrole binds primarily to the site utilized by ethoxyresorufin.	Benzo(a)pyrene	46-60	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	99-116
3587256-2	1987	We have investigated the detoxication of BP- and BP-diol-induced cytotoxicity and mutagenicity with GSH by supplementing the S9 mix used in the Chinese hamster ovary cells/hypoxanthine-guanine phosphoribosyltransferase (CHO/HGPRT) assay with GSH (6.5 mM) or GSH plus GSHT.	Benzo(a)pyrene	41-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	172-218
3587256-2	1987	We have investigated the detoxication of BP- and BP-diol-induced cytotoxicity and mutagenicity with GSH by supplementing the S9 mix used in the Chinese hamster ovary cells/hypoxanthine-guanine phosphoribosyltransferase (CHO/HGPRT) assay with GSH (6.5 mM) or GSH plus GSHT.	Benzo(a)pyrene	41-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	220-229
3105866-2	1987	In a cell-mediated mutagenesis assay, rat MEC activated 7,12-dimethylbenz(a)anthracene (DMBA) but not benzo(a)pyrene [B(a)P] to mutagenic forms, and the opposite pattern was found with human MEC.	Benzo(a)pyrene	102-116	C-C motif chemokine ligand 28	Homo sapiens	42-45
3570548-0	1987	Benzo(a)pyrene metabolism by lymphocytes from normal individuals and individuals carrying the Mediterranean variant of glucose-6-phosphate dehydrogenase.	Benzo(a)pyrene	0-14	glucose-6-phosphate dehydrogenase	Homo sapiens	119-152
3579981-4	1987	The fluorographic pattern of the protein labeling was cytochrome P-450-dependent, as was demonstrated by CO and metyrapone inhibition as well as by pretreatment of rats with inducing drugs such as 3-methylcholanthrene, benzo(a)pyrene, phenobarbitone and Aroclor 1254.	Benzo(a)pyrene	219-233	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70
3472002-5	1987	Only 1.4% of the total carcinogenicity of the flue gas condensate was found to be attributable to the amount of benzo[a]pyrene (CAS: 50-32-8) present in the condensate (1.14 mg/g condensate).	Benzo(a)pyrene	112-126	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	128-131
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	Benzo(a)pyrene	110-124	prohibitin 2	Mus musculus	289-292
2882985-3	1987	It appears that the high affinity enzyme is a polycyclic aromatic hydrocarbon-inducible isozyme of cytochrome P-450, based on competitive inhibition by 7-ethoxyresorufin and benzo[a]pyrene, and based on a significant (p less than 0.001) correlation between 7-ethoxyresorufin-O-deethylation and methylxanthine demethylation rates.	Benzo(a)pyrene	174-188	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	99-115
3112200-7	1987	BP was a specific IL-1 inhibitor, and did not inhibit thymocyte proliferation in the standard IL-1 bioassay in the absence of IL-1.	Benzo(a)pyrene	0-2	interleukin 1 alpha	Homo sapiens	18-22
3103261-0	1987	Differential induction of cytochrome P-450 catalyzed activities by polychlorinated biphenyls and benzo [a]pyrene in B6C3F1 mouse liver and lung.	Benzo(a)pyrene	97-112	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	26-42
3103261-16	1987	Lung AHH and 7-ethoxyresorufin O-deethylase activities were increased 4.3- and 3.1-fold, respectively, and cytochrome P-450 content, benzphetamine N-demethylase and nitroreductase activities were decreased 1.4-, 1.2- and 1.3-fold, respectively, after BaP administration.	Benzo(a)pyrene	251-254	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	5-8
3103934-10	1987	The kinetic characteristics of BP metabolism by UT-microsomes are highly sensitive to the presence of very small but variable amounts (2-25 pmol/mg) of the very active cytochrome P-450c, which is the predominant form in MC-microsomes.	Benzo(a)pyrene	31-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	168-185
3103934-11	1987	The major effect of elevated levels of P-450c is an 8-fold increase in DE formation at low concentrations of BP due to a lowering of Km (7.9-2.6 microM) and an increase in the regioselectivity for DE formation from 7,8-dihydrodiol (5-15% of total BP metabolites).	Benzo(a)pyrene	109-111	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	39-45
3103934-11	1987	The major effect of elevated levels of P-450c is an 8-fold increase in DE formation at low concentrations of BP due to a lowering of Km (7.9-2.6 microM) and an increase in the regioselectivity for DE formation from 7,8-dihydrodiol (5-15% of total BP metabolites).	Benzo(a)pyrene	247-249	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	39-45
3564534-3	1987	The profiles of benzo[a]pyrene metabolites formed by the reconstituted P-450MC systems were different from that obtained with rat-lung microsomes, indicating the presence of several unknown metabolites in the reconstituted systems containing NADPH-cytochrome P-450 reductase and epoxide hydrolase.	Benzo(a)pyrene	16-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	71-78
2953554-6	1987	The changes in IR-ANF in the atria and plasma occur rather as an adaptive and regulatory response to increasing BP.	Benzo(a)pyrene	112-114	natriuretic peptide A	Homo sapiens	18-21
2830152-7	1987	Menadione inhibited BaP oxygenation in microsomal preparations, by siphoning off electrons from cytochrome P-450, while addition of UDPGA reversed this effect by glucuronidation of menadiol.	Benzo(a)pyrene	20-23	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	96-112
2830152-13	1987	The important role of the balance between quinone reductase and UDP-glucuronyltransferase activities in the coupling with BaP oxygenation is discussed.	Benzo(a)pyrene	122-125	crystallin, zeta	Mus musculus	42-59
3497114-0	1987	Effect of in vivo administration of the carcinogen benzo(a)pyrene on interleukin-2 and interleukin-3 production.	Benzo(a)pyrene	51-65	interleukin 2	Mus musculus	69-82
3497114-0	1987	Effect of in vivo administration of the carcinogen benzo(a)pyrene on interleukin-2 and interleukin-3 production.	Benzo(a)pyrene	51-65	interleukin 3	Mus musculus	87-100
3497114-3	1987	Significant suppression by BaP of IL-2, but not IL-3, production following BaP exposure was observed.	Benzo(a)pyrene	27-30	interleukin 2	Mus musculus	34-38
3497114-3	1987	Significant suppression by BaP of IL-2, but not IL-3, production following BaP exposure was observed.	Benzo(a)pyrene	75-78	interleukin 2	Mus musculus	34-38
3497114-4	1987	Further, exogenous recombinant IL-2 reconstituted the ability of splenocytes from benzo(a)pyrene treated mice to generate IgM antibody producing cells to the T-dependent antigens of sheep red blood cells.	Benzo(a)pyrene	82-96	interleukin 2	Mus musculus	31-35
3794390-6	1987	Wide interindividual variation was observed in basal cytochrome P-450-dependent aryl hydrocarbon hydroxylase (AHH) activity which ranged from 0.6-17.6 fmol water-soluble BP metabolites/h/hair follicle (mean +/- SE of 32 individuals was 9.7 +/- 0.9).	Benzo(a)pyrene	170-172	aryl hydrocarbon receptor repressor	Homo sapiens	110-113
3576073-4	1987	It has been hypothesized that the NADPH level could be rate-limiting for the NADPH-dependent steps of BaP metabolic activation.	Benzo(a)pyrene	102-105	2,4-dienoyl-CoA reductase 1	Homo sapiens	34-39
3151500-14	1987	Aflatoxin B1, cyclophosphamide, dibutylnitrosamine, and benzo[a]pyrene mutated SD1 and/or XEM1 and XEM2 cells, but were inactive in parental V79 cells.	Benzo(a)pyrene	56-70	CUP2Q35	Homo sapiens	79-82
3151500-15	1987	The mutagenicity of benzo[a]pyrene 7,8-trans-dihydrodiol was about 1000 times more potent in XEM1 and XEM2 cells than in SD1 and V79 cells.	Benzo(a)pyrene	20-34	CUP2Q35	Homo sapiens	121-124
3498153-5	1987	The increased binding of [3H]BP to liver DNA of rats fed the high level of menhaden oil may be due, in part, to increases in the MFO responsible for BP activation (as suggested by increased cytochrome P-450 level and total BP hydroxylase activity).	Benzo(a)pyrene	29-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	190-206
2430791-1	1986	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyribosinosinic-polyribocytidylic acid was inhibited when murine L-929 cells were pretreated with the carcinogen benzo[a]pyrene (BP).	Benzo(a)pyrene	174-188	interferon alpha B	Mus musculus	17-38
2430791-1	1986	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyribosinosinic-polyribocytidylic acid was inhibited when murine L-929 cells were pretreated with the carcinogen benzo[a]pyrene (BP).	Benzo(a)pyrene	174-188	interferon alpha	Mus musculus	40-49
2430791-1	1986	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyribosinosinic-polyribocytidylic acid was inhibited when murine L-929 cells were pretreated with the carcinogen benzo[a]pyrene (BP).	Benzo(a)pyrene	190-192	interferon alpha B	Mus musculus	17-38
2430791-1	1986	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyribosinosinic-polyribocytidylic acid was inhibited when murine L-929 cells were pretreated with the carcinogen benzo[a]pyrene (BP).	Benzo(a)pyrene	190-192	interferon alpha	Mus musculus	40-49
2430791-2	1986	Exposure of L-929 cells for 24 hr to BP was required to inhibit IFN-alpha/beta induction.	Benzo(a)pyrene	37-39	interferon alpha	Mus musculus	64-73
3795254-0	1986	Mutagenic activation of biliary metabolites of benzo(a)pyrene by beta-glucuronidase-positive bacteria in human faeces.	Benzo(a)pyrene	47-61	glucuronidase beta	Homo sapiens	65-83
3795254-7	1986	Extracts of beta-glucuronidase-positive bacteria increased the mutagenicity of metabolites of benzo(a)pyrene, as did faecal extracts, but extracts of beta-glucuronidase-negative bacteria did not.	Benzo(a)pyrene	94-108	glucuronidase beta	Homo sapiens	12-30
3590196-1	1986	Percutaneous absorption of 14C-labeled benzo[a]pyrene (BaP) was studied in five-day in vivo and in vitro experiments with female Sprague-Dawley rats following single topical doses of 9-10 micrograms/cm2.	Benzo(a)pyrene	39-53	prohibitin 2	Rattus norvegicus	55-58
2431654-1	1986	The effect of dicoumarol on glucuronidation of 3-OH-benzo(a)pyrene (BP) appears to be due to inhibition of UDPglucuronosyltransferase (UDPGT) and not to an inhibited DT-diaphorase (NAD(P)H:quinone oxidoreductase); to date the only enzyme known to be inhibited by dicoumarol.	Benzo(a)pyrene	68-70	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	166-179
3759965-2	1986	For each base pair which adopts a left-handed conformation in the plasmids with (dC-dG)16 sequences, the delta HBZ and delta SBZ are -2.1 kcal/mol bp and -8.8 cal/K-mol bp, respectively.	Benzo(a)pyrene	147-149	hemoglobin subunit zeta	Homo sapiens	111-124
3769056-8	1986	In addition to the diols, an unidentified BP metabolite was found that eluted between BP-9,10- and 4,5-diol on a reverse-phase high-performance liquid chromatography (HPLC) system and which represented a major product in extracts of incubations of BP with both induced and uninduced skin and lung microsomal fractions.	Benzo(a)pyrene	42-44	immunoglobulin kappa chain variable 9-119	Mus musculus	86-90
2433367-1	1986	Benzo[a]pyrene (BaP) metabolites were assessed, with and without enzymatic activation by rat liver S9, for their inhibitory activities on influenza virus induction of interferon-alpha/beta (IFN-alpha/beta) in mammalian (LLC-MK2) cell cultures.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
2433367-1	1986	Benzo[a]pyrene (BaP) metabolites were assessed, with and without enzymatic activation by rat liver S9, for their inhibitory activities on influenza virus induction of interferon-alpha/beta (IFN-alpha/beta) in mammalian (LLC-MK2) cell cultures.	Benzo(a)pyrene	0-14	interferon alpha 1	Homo sapiens	190-193
3576073-4	1987	It has been hypothesized that the NADPH level could be rate-limiting for the NADPH-dependent steps of BaP metabolic activation.	Benzo(a)pyrene	102-105	2,4-dienoyl-CoA reductase 1	Homo sapiens	77-82
3096852-9	1986	Diet-induced changes in monooxygenase activities were found to be the best indicators of changes in microsome-mediated BP mutagenesis and AFB1 mutagenesis and binding to DNA in vitro, with a direct correlation between high AHH and/or ECD activities and the levels of mutagenic response to BP or AFB1 in the Ames assay and of DNA binding of AFB1.	Benzo(a)pyrene	289-291	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	223-226
3734486-11	1986	The differential responses in AHH activity were found to parallel the capacity of skin microsomal enzymes to enhance the binding of [3H]-BP to DNA.	Benzo(a)pyrene	137-139	aryl hydrocarbon receptor repressor	Homo sapiens	30-33
3733707-6	1986	22-ABC also inhibited the metabolism of benzo(a)pyrene attributable to cytochrome P-450 1 but did not inhibit that induced by treatment with rifampicin or 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Benzo(a)pyrene	40-54	cytochrome P450 2C5	Oryctolagus cuniculus	71-89
2428858-0	1986	Induction of aryl hydrocarbon hydroxylase in rat tissue following intratracheal instillation of diesel particulate extract and benzo[a]pyrene.	Benzo(a)pyrene	127-141	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-41
3096979-0	1986	Pulmonary microsomal cytochrome P-450 from 3-methylcholanthrene-treated hamsters: purification, characterization, and metabolism of benzo(a)pyrene.	Benzo(a)pyrene	132-146	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	32-37
3096979-5	1986	In a reconstituted system, pulmonary P-450MC efficiently catalyzed benzo(a)pyrene (BP) hydroxylation, but showed low activities for 7-ethoxycoumarin O-deethylation and benzphetamine N-demethylation.	Benzo(a)pyrene	67-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	37-44
3096979-5	1986	In a reconstituted system, pulmonary P-450MC efficiently catalyzed benzo(a)pyrene (BP) hydroxylation, but showed low activities for 7-ethoxycoumarin O-deethylation and benzphetamine N-demethylation.	Benzo(a)pyrene	83-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	37-44
3096979-7	1986	When incubated with [14C]BP in a reconstituted system containing NADPH-reductase and epoxide hydrolase, hamster pulmonary P-450MC formed much higher amounts of BP diols, especially 7,8-diol, than were formed by rat pulmonary P-450MC.	Benzo(a)pyrene	25-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	122-129
3096979-7	1986	When incubated with [14C]BP in a reconstituted system containing NADPH-reductase and epoxide hydrolase, hamster pulmonary P-450MC formed much higher amounts of BP diols, especially 7,8-diol, than were formed by rat pulmonary P-450MC.	Benzo(a)pyrene	25-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	225-232
3011254-14	1986	Aryl hydrocarbon hydroxylase, the major enzyme induced under control of the Ah receptor, plays an important role in the metabolism of several carcinogens including polycyclic aromatic hydrocarbons such as benzo(a)pyrene.	Benzo(a)pyrene	205-219	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-28
3011254-14	1986	Aryl hydrocarbon hydroxylase, the major enzyme induced under control of the Ah receptor, plays an important role in the metabolism of several carcinogens including polycyclic aromatic hydrocarbons such as benzo(a)pyrene.	Benzo(a)pyrene	205-219	aryl hydrocarbon receptor	Homo sapiens	76-87
2873987-6	1986	Our results indicate that the substance P inhibitor, capsaicin, is also an inhibitor of epidermal BP metabolism and DNA binding of its metabolites.	Benzo(a)pyrene	98-100	tachykinin precursor 1	Homo sapiens	30-41
3084074-3	1986	Analysis of BaP:deoxyribonucleoside adducts resolved by immobilized boronate chromatography and reversephase high-performance liquid chromatography demonstrated the presence of three BaP:deoxyribonucleoside adducts in both cells: M2, MS1, and MS2 in a ratio of 1.6:1:14.	Benzo(a)pyrene	183-186	MS	Homo sapiens	234-237
3099691-12	1986	The parallel improvement of CIN and CPAH in GR confirms a favorable effect of BP control on early vascular lesions.	Benzo(a)pyrene	78-80	carboxypeptidase A6	Homo sapiens	36-40
3084074-3	1986	Analysis of BaP:deoxyribonucleoside adducts resolved by immobilized boronate chromatography and reversephase high-performance liquid chromatography demonstrated the presence of three BaP:deoxyribonucleoside adducts in both cells: M2, MS1, and MS2 in a ratio of 1.6:1:14.	Benzo(a)pyrene	183-186	MS2	Homo sapiens	243-246
3084074-5	1986	MS2 was identified as (+)-anti-BaPDE:deoxyguanosine (dGuo) for it cochromatographed with a [14C]-(+)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS2 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols.	Benzo(a)pyrene	31-34	MS2	Homo sapiens	0-3
3084074-5	1986	MS2 was identified as (+)-anti-BaPDE:deoxyguanosine (dGuo) for it cochromatographed with a [14C]-(+)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS2 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols.	Benzo(a)pyrene	31-34	MS2	Homo sapiens	162-165
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	55-57	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	98-114
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	55-57	complement C3	Rattus norvegicus	251-254
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	55-57	complement C6	Rattus norvegicus	259-262
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	148-150	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	174-190
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	148-150	complement C3	Rattus norvegicus	251-254
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	148-150	complement C6	Rattus norvegicus	259-262
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	148-150	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	174-190
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	148-150	complement C3	Rattus norvegicus	251-254
3707619-8	1986	These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6.	Benzo(a)pyrene	148-150	complement C6	Rattus norvegicus	259-262
2872200-10	1986	However, they differed in their basal ALDH activities and in ALDH inducibility by 3-methylcholanthrene, benzo(a)pyrene, and phenobarbital.	Benzo(a)pyrene	104-118	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	61-65
2422427-7	1986	Reduced hepatic cytochrome P-450 contents correlated with decreased abilities of liver homogenates to metabolically activate benzo [a]pyrene (CAS: 50-32-8) and N-acetyl-2-aminofluorene (CAS: 53-96-3), as scored in an Ames Salmonella typhimurium revertant assay.	Benzo(a)pyrene	125-140	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	16-32
2423085-3	1986	The diversion of electrons from cytochrome P-450 enzymes results in a large decrease in the percent of benzo(a)pyrene metabolized by rat liver microsomes as measured by HPLC.	Benzo(a)pyrene	103-117	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-48
3697359-5	1986	Differences in the conformational change were observed between the two enzymes, and the conformational change of cytochrome P-450 II-d using benzo[a]pyrene as a substrate was different from that using 7-ethoxycoumarin.	Benzo(a)pyrene	141-155	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	113-129
3697359-6	1986	The results suggest that the substrate-binding sites of the two enzymes differ in position toward the heme, and that there are at least two different substrate sites in cytochrome P-450 II-d, one for benzo[a]pyrene and another for 7-ethoxycoumarin.	Benzo(a)pyrene	200-214	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	169-185
3963817-4	1986	The metabolism of benzo[a]pyrene in these preparations was found to be catalyzed by isozyme 6, not by isozyme 5 as previously concluded.	Benzo(a)pyrene	18-32	cytochrome P450 1A1	Oryctolagus cuniculus	84-93
3963817-6	1986	Although benzo[a]pyrene and 7-ethoxyresorufin are both substrates for isozyme 6, the pulmonary microsomal metabolism of these compounds was not increased to the same extent by treatment of rabbits with 2,3,7,8-tetrachlorodibenzo-p-dioxin (about 13-fold for 7-ethoxyresorufin and less than 2-fold for BP).	Benzo(a)pyrene	9-23	cytochrome P450 1A1	Oryctolagus cuniculus	70-79
2873214-0	1986	Effect of cholera toxin on the induction of gamma-glutamyl transpeptidase-positive clones by benzo(a)pyrene in embryonic mouse tongue cells in culture.	Benzo(a)pyrene	93-107	gamma-glutamyltransferase 1	Mus musculus	44-73
2873214-2	1986	It was observed that cholera toxin not only promotes growth of fibroblasts in primary cell culture, but it also enhances the GGT-positive foci induced by benzo(a)pyrene.	Benzo(a)pyrene	154-168	gamma-glutamyltransferase 1	Mus musculus	125-128
3769749-1	1986	In mutagenicity and carcinogenicity assays using micronucleus test, N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), 50 mg/kg or benzo(a)pyrene (BaP), 100 mg/kg did not increase the incidence of micronuclei in polychromatic erythrocytes in bone marrow of mice.	Benzo(a)pyrene	125-139	prohibitin 2	Mus musculus	141-144
3510271-8	1986	All BP components from trout PNS and CNS myelins bound to antibodies against human myelin basic protein.	Benzo(a)pyrene	4-6	myelin basic protein	Homo sapiens	83-103
2943442-0	1986	[Studies on the relationship between the activities of aryl hydrocarbon hydroxylase and the intermediate products of benzo(a)pyrene].	Benzo(a)pyrene	117-131	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	55-83
3709938-3	1986	Menadione has a high affinity for the NADPH dependent cytochrome P-450 reductase and acts as a competitive inhibitor of cytochrome P-450 reductase in the metabolism of benzo(a)pyrene.	Benzo(a)pyrene	168-182	cytochrome p450 oxidoreductase	Homo sapiens	38-80
3084074-6	1986	MS1 was identified as (-)-anti-BaPDE:dGuo for MS1 eluted in the same relative position as a (-)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS1 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols.	Benzo(a)pyrene	31-34	MS	Homo sapiens	0-3
3084074-6	1986	MS1 was identified as (-)-anti-BaPDE:dGuo for MS1 eluted in the same relative position as a (-)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS1 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols.	Benzo(a)pyrene	31-34	MS	Homo sapiens	46-49
3084074-6	1986	MS1 was identified as (-)-anti-BaPDE:dGuo for MS1 eluted in the same relative position as a (-)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS1 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols.	Benzo(a)pyrene	31-34	MS	Homo sapiens	46-49
3943078-1	1986	Male Swiss mice and Wistar rats were treated topically with 250 nmol/mouse and 750 nmol/rat of [3H]benzo[a]pyrene ([3H]BaP).	Benzo(a)pyrene	99-113	prohibitin 2	Rattus norvegicus	119-122
3488279-0	1986	Modulation of interleukin-1 production by macrophages following benzo(a)pyrene exposure.	Benzo(a)pyrene	64-78	interleukin 1 complex	Mus musculus	14-27
3488279-1	1986	The effects of benzo(a)pyrene (BaP), a highly prevalent environmental carcinogen, on the ability of peritoneal exudate macrophages to produce the secretory immunomodulatory molecule interleukin-1 (IL-1) in vitro was examined.	Benzo(a)pyrene	15-29	interleukin 1 complex	Mus musculus	182-201
3488279-1	1986	The effects of benzo(a)pyrene (BaP), a highly prevalent environmental carcinogen, on the ability of peritoneal exudate macrophages to produce the secretory immunomodulatory molecule interleukin-1 (IL-1) in vitro was examined.	Benzo(a)pyrene	31-34	interleukin 1 complex	Mus musculus	182-201
3488279-2	1986	A dose-dependent increase in lipopolysaccharide stimulated IL-1 production concomitant with decreased cell viabilities was noted in macrophages cultured in the presence of BaP.	Benzo(a)pyrene	172-175	interleukin 1 complex	Mus musculus	59-63
3488279-3	1986	Antibody responses which are suppressed in BaP dosed mice can be reconstituted in vitro by the addition of exogenous interleukin-1.	Benzo(a)pyrene	43-46	interleukin 1 complex	Mus musculus	117-130
3488279-5	1986	Furthermore, BaP induced suppression of antibody responsiveness may be a result of alterations in production of IL-1.	Benzo(a)pyrene	13-16	interleukin 1 complex	Mus musculus	112-116
3758464-4	1986	Analysis of inhibition of monooxygenase reactions with antibodies has showed that only P-450c was involved in metabolism of BP and 7-ER.	Benzo(a)pyrene	124-126	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	87-93
3758464-8	1986	Metabolism of BP in the PB-microsomes of the neonatal rats was inhibited neither by anti-P-450b/e nor anti-P-450c in contrast to the adults, where this reaction was inhibited by antibodies against P-450b/e.	Benzo(a)pyrene	14-16	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	89-113
3758464-8	1986	Metabolism of BP in the PB-microsomes of the neonatal rats was inhibited neither by anti-P-450b/e nor anti-P-450c in contrast to the adults, where this reaction was inhibited by antibodies against P-450b/e.	Benzo(a)pyrene	14-16	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	89-97
3125402-0	1986	Activation of benzo[a]pyrene and aflatoxin B1 to mutagenic chemical species by microsomal preparations from rat liver and small intestine in relation to microsomal epoxide hydrolase.	Benzo(a)pyrene	14-28	epoxide hydrolase 1	Rattus norvegicus	153-181
3941663-0	1986	Inhibitory effects of the phorbolester TPA and cigarette smoke condensate on the mutagenicity of benzo[a]pyrene in a co-cultivation system.	Benzo(a)pyrene	97-111	plasminogen activator, tissue type	Rattus norvegicus	39-42
2875537-7	1986	Aryl hydrocarbon hydroxylase activity was measured with two different substrates, benzo(a)pyrene and 7-ethoxyresorufin.	Benzo(a)pyrene	82-96	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-28
4084307-1	1985	The isoenzymes of human and rat lung glutathione S-transferase (GST) differ among themselves in their activities towards the epoxides of benzo(a)pyrene (BP).	Benzo(a)pyrene	137-151	hematopoietic prostaglandin D synthase	Rattus norvegicus	37-62
4084307-1	1985	The isoenzymes of human and rat lung glutathione S-transferase (GST) differ among themselves in their activities towards the epoxides of benzo(a)pyrene (BP).	Benzo(a)pyrene	137-151	hematopoietic prostaglandin D synthase	Rattus norvegicus	64-67
4084307-1	1985	The isoenzymes of human and rat lung glutathione S-transferase (GST) differ among themselves in their activities towards the epoxides of benzo(a)pyrene (BP).	Benzo(a)pyrene	153-155	hematopoietic prostaglandin D synthase	Rattus norvegicus	37-62
4084307-1	1985	The isoenzymes of human and rat lung glutathione S-transferase (GST) differ among themselves in their activities towards the epoxides of benzo(a)pyrene (BP).	Benzo(a)pyrene	153-155	hematopoietic prostaglandin D synthase	Rattus norvegicus	64-67
2415268-2	1985	Pre-incubation of the keratinocyte cultures with greater than 100 units/ml IFN-beta, but not mock IFN, partially inhibited DMBA (25-60%) and BP (25-63%) dependent mutagenesis, but had little effect on the cytotoxicities of these agents.	Benzo(a)pyrene	141-143	interferon beta 1, fibroblast	Mus musculus	75-83
3830701-7	1985	Binding of benzo[a]pyrene (BP) to mouse skin DNA occurs predominantly at C-6, the position of highest charge localization in the BP radical cation, and binding of 6-methyl BP to DNA in mouse skin yields a major adduct with the 6-methyl group bound to the 2-amino group of deoxyguanosine.	Benzo(a)pyrene	11-25	complement component 6	Mus musculus	73-76
3830701-7	1985	Binding of benzo[a]pyrene (BP) to mouse skin DNA occurs predominantly at C-6, the position of highest charge localization in the BP radical cation, and binding of 6-methyl BP to DNA in mouse skin yields a major adduct with the 6-methyl group bound to the 2-amino group of deoxyguanosine.	Benzo(a)pyrene	27-29	complement component 6	Mus musculus	73-76
4063404-5	1985	The mode of inhibition of various substrates metabolism by antibodies in neonatal rat microsomes suggests that the 3-methylcholantrene-induced cytochrome P-448, like in adult rats, participates in the hydroxylation of benz(a)pyrene and O-deethylation of 7-etoxyresorufin.	Benzo(a)pyrene	218-231	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	143-159
4077222-2	1985	The aryl-hydrocarbon hydroxylase activity was examined by metabolism of benzo[a]pyrene in microsomes prepared from intimal and smooth muscle cell scrapings of the hog thoracic aorta.	Benzo(a)pyrene	72-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-32
4056945-12	1985	In addition, BP feeding produced numerous BP X sex and BP X protein interactions for plasma amino acid concentrations.	Benzo(a)pyrene	13-15	nucleosome assembly protein 1-like 2	Mus musculus	42-46
4056945-12	1985	In addition, BP feeding produced numerous BP X sex and BP X protein interactions for plasma amino acid concentrations.	Benzo(a)pyrene	13-15	nucleosome assembly protein 1-like 2	Mus musculus	55-59
2866028-3	1985	Cytochrome P-450 dependent metabolism of benzo[a]pyrene, aldrin and ethoxyresorufin was 43-54% lower than in the parent cell suspension, glucuronidation of 3-hydroxybenzo[a]pyrene (3-OH-BP) and hydrolysis of styrene oxide were increased 1.5- and 1.4-fold, respectively.	Benzo(a)pyrene	41-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
3875401-6	1985	Since various cytochrome P-450 isozymes catalyze the oxidative attack on the benzo(a)pyrene molecule at defined preferential sites, this analysis also provides an indirect trace of potential differences in the pattern of cytochrome P-450 isozymes present in the individual membranes.	Benzo(a)pyrene	77-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
3875401-6	1985	Since various cytochrome P-450 isozymes catalyze the oxidative attack on the benzo(a)pyrene molecule at defined preferential sites, this analysis also provides an indirect trace of potential differences in the pattern of cytochrome P-450 isozymes present in the individual membranes.	Benzo(a)pyrene	77-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	221-237
2996532-1	1985	Sonic disrupted mitoplasts from 3-methylcholanthrene (MCA) treated rats can catalyze the formation of benzo(a)pyrene (BaP) adducts with calf thymus DNA in the presence of an NADPH generating system.	Benzo(a)pyrene	102-116	prohibitin 2	Rattus norvegicus	118-121
4074682-0	1985	Binding of benzo[a]pyrene by purified cytochrome P-450c.	Benzo(a)pyrene	11-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	38-55
4074682-2	1985	The fluorescence of BP is quenched by the presence of cytochrome P-450c in proportion to the concentration of the cytochrome in the micelles and in accord with stoichiometric complex formation.	Benzo(a)pyrene	20-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	54-71
4074682-3	1985	Parallel optical titrations indicate a change in spin state of P-450c to a predominantly high-spin state that correlates directly with the percentage fluorescence quenching of complexed BP.	Benzo(a)pyrene	186-188	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	63-69
4074682-6	1985	The Kd for the interaction of BP with P-450c is exceptionally low (10 nM) relative to the Km for monooxygenation (ca.	Benzo(a)pyrene	30-32	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	38-44
4074683-0	1985	Selectivity in the binding of hydroxylated benzo[a]pyrene derivatives to purified cytochrome P-450c.	Benzo(a)pyrene	43-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	82-99
4074683-1	1985	The interaction of rat liver microsomal cytochrome P-450c with potential benzo[a]pyrene (BP) metabolites has been compared with the binding of BP by optical and fluorescence spectroscopy.	Benzo(a)pyrene	73-87	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	40-57
4074683-1	1985	The interaction of rat liver microsomal cytochrome P-450c with potential benzo[a]pyrene (BP) metabolites has been compared with the binding of BP by optical and fluorescence spectroscopy.	Benzo(a)pyrene	89-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	40-57
4074683-2	1985	Fluorescence quenching of the phenolic derivatives of BP derives from 1:1 complex formation with P-450c, is a function of the position of the hydroxyl substituent, and correlates with the concomitant increase in high-spin cytochrome observed in parallel optical titrations.	Benzo(a)pyrene	54-56	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	97-103
4074683-5	1985	Kd determinations with purified P-450c indicated very strong binding of BP phenols that induce high-spin complexes (4-, 5-, 9-, 10-, 11-, and 12-phenols; Kd = 3-25 nM).	Benzo(a)pyrene	72-74	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	32-38
4074683-7	1985	Inhibition of BP metabolism catalyzed by P-450c with BP phenols correlated with their respective dissociation constants.	Benzo(a)pyrene	14-16	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	41-47
4074683-7	1985	Inhibition of BP metabolism catalyzed by P-450c with BP phenols correlated with their respective dissociation constants.	Benzo(a)pyrene	53-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	41-47
4061096-1	1985	The metabolism of benzo(a)pyrene (BaP) was studied in isolated perfused and ventilated lungs from two inbred strains of mice.	Benzo(a)pyrene	18-32	prohibitin 2	Mus musculus	34-37
2996731-5	1985	Previous reports have shown that the commercial halogenated biphenyl mixtures, fireMaster BP-6, and Aroclor 1254 are mixed-type inducers and that microsomes from rats pretreated with these mixtures markedly enhance the overall metabolism of benzo[a]pyrene.	Benzo(a)pyrene	241-255	Blood pressure QTL 6	Rattus norvegicus	90-94
2996731-6	1985	Not surprisingly, the metabolism of benzo[a]pyrene by microsomes from rats pretreated with the mixed-type inducers, 2,3,3",4,4"-penta-,2,3,3",4,4",5-hexa-, and 2",3,3",4,4",5-hexa- chlorobiphenyl was also increased and the metabolic profile was similar to that observed with fireMaster BP-6 and Aroclor 1254 induced microsomes.	Benzo(a)pyrene	36-50	Blood pressure QTL 6	Rattus norvegicus	286-290
4055640-5	1985	The method is precise (+/- 10-15% relative standard deviation) and yields 85% or better BaP recovery at the ng/cig.	Benzo(a)pyrene	88-91	fibronectin 1	Homo sapiens	111-114
2994646-2	1985	However, exposure of cultures to the hormone adrenocorticotropin (ACTH) for 48 hours stimulated benzo[a]pyrene metabolism 3-fold.	Benzo(a)pyrene	96-110	proopiomelanocortin	Homo sapiens	66-70
4017182-1	1985	We have studied the occurrence and persistence of DNA damage in the hepatic and pulmonary tissues of fetal, newborn and adult CD1 mice exposed to selected doses of benzo[a]pyrene (BP) by utilizing the alkaline elution technique.	Benzo(a)pyrene	180-182	CD1 antigen complex	Mus musculus	126-129
3839642-0	1985	Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene.	Benzo(a)pyrene	96-110	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
3839642-4	1985	The results indicate that various cytochrome P-450 isozymes of rat liver exhibit different stereoselective properties in catalyzing the epoxidation reactions at the K region of BA and of BP.	Benzo(a)pyrene	187-189	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	34-50
18964002-3	1985	In the extraction equilibrium of Co(II) the rate-determining step seems to be the complexation of hydrated Co(II) by BP in the aqueous phase.	Benzo(a)pyrene	117-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
18964002-3	1985	In the extraction equilibrium of Co(II) the rate-determining step seems to be the complexation of hydrated Co(II) by BP in the aqueous phase.	Benzo(a)pyrene	117-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-113
4017178-1	1985	To determine the relationship of the benzo[a]pyrene (BaP)-DNA adducts formed in the activator cells of a cell-mediated mutation assay to the adducts formed in the target cells and to mutation induction, irradiated second passage Wistar rat embryo (WRE) cells and V79 Chinese hamster lung cells were exposed to [3H]BaP for 5, 24 and 48 h under the conditions of a cell-mediated mutation assay.	Benzo(a)pyrene	37-51	prohibitin 2	Rattus norvegicus	53-56
2988922-12	1985	A polycyclic hydrocarbon, benzo(a)pyrene, which causes induction of aryl hydrocarbon hydroxylase activity in fetal hepatocytes, inhibited the stimulation of aromatase activity by dexamethasone.	Benzo(a)pyrene	26-40	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	68-96
3900057-10	1985	The spectral properties and monooxygenase activities towards benzo(a)pyrene and 7-ethoxycoumarin of the cleaved P-450MC were nearly the same as those of intact P-450MC.	Benzo(a)pyrene	61-75	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	112-119
2411747-3	1985	Therefore, the BP was first cleaved specifically between residues 97 and 98 with thrombin, and the two resulting fragments were separated by ion-exchange chromatography.	Benzo(a)pyrene	15-17	coagulation factor II, thrombin	Homo sapiens	81-89
2989797-0	1985	Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.	Benzo(a)pyrene	79-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-12
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Benzo(a)pyrene	186-200	interferon alpha B	Mus musculus	17-38
3928617-7	1985	On the other hand, the activities for the oxidations of benzo[a]pyrene, 7-ethoxycoumarin, biphenyl, and estradiol-17 beta varied greatly among the forms of cytochrome P-450.	Benzo(a)pyrene	56-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	156-172
3998503-7	1985	The reduction in AHH activity paralleled the levels of enzyme-mediated binding of radiolabeled BP metabolites and of BPDE-I to epidermal DNA.	Benzo(a)pyrene	95-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	17-20
2581993-1	1985	Myelin basic protein (BP)-specific T-cell lines and clones have been derived from SJL/J mice which had been sensitized with BP in complete Freund"s adjuvant.	Benzo(a)pyrene	22-24	myelin basic protein	Mus musculus	0-20
4039566-0	1985	Involvement of cytochrome b5 in the hepatic microsomal metabolism of benzo(a)pyrene.	Benzo(a)pyrene	69-83	cytochrome b5 type A	Homo sapiens	15-28
4039566-4	1985	When the observed rates of 7,8 and 9,10 diol formation per nmole P450 for chow-fed animals are plotted vs. the b5/P450 ratio a positive correlation was observed suggesting that cytochrome b5 participates directly in the microsomal metabolism of benzo(a)pyrene.	Benzo(a)pyrene	245-259	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	114-118
4039566-4	1985	When the observed rates of 7,8 and 9,10 diol formation per nmole P450 for chow-fed animals are plotted vs. the b5/P450 ratio a positive correlation was observed suggesting that cytochrome b5 participates directly in the microsomal metabolism of benzo(a)pyrene.	Benzo(a)pyrene	245-259	cytochrome b5 type A	Homo sapiens	177-190
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Benzo(a)pyrene	186-200	interferon alpha	Mus musculus	40-49
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Benzo(a)pyrene	202-204	interferon alpha B	Mus musculus	17-38
3996338-1	1985	The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP).	Benzo(a)pyrene	202-204	interferon alpha	Mus musculus	40-49
3996338-2	1985	When BP was added to the cell cultures simultaneously with reduced glutathione (GSH) or beta-naphthoflavone (B-NF), followed 24 hr later by the IFN-alpha/beta inducer, the inhibitory effects of BP on IFN-alpha/beta induction were abrogated.	Benzo(a)pyrene	5-7	interferon alpha	Mus musculus	144-153
3996338-2	1985	When BP was added to the cell cultures simultaneously with reduced glutathione (GSH) or beta-naphthoflavone (B-NF), followed 24 hr later by the IFN-alpha/beta inducer, the inhibitory effects of BP on IFN-alpha/beta induction were abrogated.	Benzo(a)pyrene	5-7	interferon alpha	Mus musculus	200-209
3996338-4	1985	These results suggest that BP must be metabolically activated to inhibit the induction of IFN-alpha/beta.	Benzo(a)pyrene	27-29	interferon alpha	Mus musculus	90-99
4015401-7	1985	Induction of aryl hydrocarbon hydroxylase activity in the cultures with 5,6-benzoflavone (10 microM) or benz(a)anthracene (10 microM) caused a decrease (75 and 46% of the control value respectively) in BP-DNA binding.	Benzo(a)pyrene	202-204	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-41
3975919-1	1985	Mild acid hydrolysis of globin preparations from erythrocytes of mice, previously exposed topically to benzo[a]pyrene (BaP), releases tetrols which are detectable by HPLC/fluorescence analysis.	Benzo(a)pyrene	103-117	prohibitin 2	Mus musculus	119-122
3995102-3	1985	Only one cytochrome fraction (cytochrome P-450 C) possessed a high activity upon benz(a)pyrene hydroxylation.	Benzo(a)pyrene	81-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	30-48
3995102-9	1985	Using rocket immunoelectrophoresis, cytochrome P-450 C possessing a high (as compared to benz(a)pyrene metabolism) activity (18 nmol/min/nmol cytochrome) and a high (60-70%) content in 3-methylcholanthrene-induced rat liver microsomes was shown to give a relatively high yield.	Benzo(a)pyrene	89-102	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	36-54
4015664-7	1985	Uridine-diphospho-glucuronosyl-transferase (UDP-GT) activity in normal and vitamin A deficient groups was enhanced following exposure to benzo(a)pyrene both in lung and liver.	Benzo(a)pyrene	137-151	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-42
4015664-7	1985	Uridine-diphospho-glucuronosyl-transferase (UDP-GT) activity in normal and vitamin A deficient groups was enhanced following exposure to benzo(a)pyrene both in lung and liver.	Benzo(a)pyrene	137-151	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	44-50
2982617-4	1985	Competitive binding studies with a series of monohydroxylated benzo[a]pyrene derivatives suggested the importance of electronic character in their ability to bind to the Ah receptor and to compete with TCDD for specific binding sites on the receptor.	Benzo(a)pyrene	62-76	aryl hydrocarbon receptor	Homo sapiens	170-181
2578512-4	1985	Myelin basic protein (BP)-sensitization of Le-R rats induces cells capable of mounting a proliferative response to BP in culture but incapable of transferring EAE after culture with BP.	Benzo(a)pyrene	22-24	myelin basic protein	Rattus norvegicus	0-20
2578512-4	1985	Myelin basic protein (BP)-sensitization of Le-R rats induces cells capable of mounting a proliferative response to BP in culture but incapable of transferring EAE after culture with BP.	Benzo(a)pyrene	115-117	myelin basic protein	Rattus norvegicus	0-20
3970724-2	1985	Cytochrome P-450-dependent monooxygenases were induced in mouse lung by intratracheal instillation of BaP, Aroclor-1254, or coal gas condensate (CGC) 24 hr before instillation of [3H]BaP, [3H]-2-AA, [14C]-1-NP, or [14C]PNDO.	Benzo(a)pyrene	102-105	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
3970724-2	1985	Cytochrome P-450-dependent monooxygenases were induced in mouse lung by intratracheal instillation of BaP, Aroclor-1254, or coal gas condensate (CGC) 24 hr before instillation of [3H]BaP, [3H]-2-AA, [14C]-1-NP, or [14C]PNDO.	Benzo(a)pyrene	183-186	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
3967524-9	1985	Forty-six percent of BP were obstructive (OBP).	Benzo(a)pyrene	21-23	odorant binding protein 2A	Homo sapiens	42-45
3969073-7	1985	The metabolism of benzo(a)pyrene by microsomes containing high concentrations of P-450 1 is inhibited by a monoclonal antibody specific for this cytochrome to approximately the rate exhibited by microsomes with a low concentration of P-450 1.	Benzo(a)pyrene	18-32	cytochrome P450 2C5	Oryctolagus cuniculus	81-88
3969073-7	1985	The metabolism of benzo(a)pyrene by microsomes containing high concentrations of P-450 1 is inhibited by a monoclonal antibody specific for this cytochrome to approximately the rate exhibited by microsomes with a low concentration of P-450 1.	Benzo(a)pyrene	18-32	cytochrome P450 2C5	Oryctolagus cuniculus	234-241
3969073-8	1985	The benzo(a)pyrene activity stimulated by ANF in microsomes with a low concentration of P-450 1 is not inhibited by the monoclonal antibody.	Benzo(a)pyrene	4-18	cytochrome P450 2C5	Oryctolagus cuniculus	88-95
4085395-0	1985	[Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene].	Benzo(a)pyrene	124-138	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	16-32
4085395-2	1985	Several forms of cytochrome P-450 are supposed to participate in metabolic conversion of BP.	Benzo(a)pyrene	89-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	17-33
4038675-2	1985	The system showed a clear dose response with three alkylating agents of previously demonstrated genotoxic potential and gave the anticipated positive result with benzo[a]pyrene in the presence of S-9 mix.	Benzo(a)pyrene	162-176	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Mus musculus	196-199
3996731-0	1985	The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens.	Benzo(a)pyrene	100-114	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	40-56
3996731-2	1985	An excellent direct correlation (r = 0.95) has been observed between ethoxyresorufin O-deethylase and the metabolic activation of benzo[a]pyrene to mutagens when the fraction of cytochromes P-450 present as cytochrome P-448 was altered by the administration of phenobarbitone and 3-methylcholanthrene alone or in combination with 9-hydroxyellipticine.	Benzo(a)pyrene	130-144	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	207-223
4093992-1	1985	The tissue-specific activities (units per gram tissue) of arylhydrocarbon hydroxylase benzo[a]pyrene [AHH(BaP)] (EC 1.14.14.2) in human, mouse, rat, and hamster have been reviewed.	Benzo(a)pyrene	86-100	aryl hydrocarbon receptor repressor	Homo sapiens	102-105
4093992-1	1985	The tissue-specific activities (units per gram tissue) of arylhydrocarbon hydroxylase benzo[a]pyrene [AHH(BaP)] (EC 1.14.14.2) in human, mouse, rat, and hamster have been reviewed.	Benzo(a)pyrene	106-110	aryl hydrocarbon receptor repressor	Homo sapiens	102-105
4000618-0	1985	Kinetics of inhibition of in vitro interferon-alpha/beta production after benzo-(a)-pyrene exposure.	Benzo(a)pyrene	74-90	interferon alpha	Mus musculus	35-51
4000618-4	1985	After 24 h, IFN-alpha/beta production in BP-treated cells began to rise and reached levels seen in untreated cells by 48 h. These data indicated that IFN induction was not completely inhibited by BP treatment, but, rather, the peak of IFN production was delayed.	Benzo(a)pyrene	41-43	interferon alpha	Mus musculus	12-21
4070009-5	1985	Benzo[a]pyrene induced its own metabolism by a slightly greater amount in the vitamin-sufficient rats, but it was not to the level of the deficient group, although the levels of cytochrome P450 were still below those of the deficient rats.	Benzo(a)pyrene	0-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	178-193
4070009-6	1985	In discussing lung microsomes, benzo[a]pyrene pre-treatment of deficient rats resulted in slightly elevated levels of cytochrome P450 and a slightly greater rate of metabolism of benzo[a]pyrene compared with rats fed the complete diet.	Benzo(a)pyrene	31-45	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-133
6435901-0	1984	Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450.	Benzo(a)pyrene	26-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	103-119
6438082-3	1984	Monooxygenation of 7,8-dihydrodiol was, surprisingly, 5 to 10 times more sensitive than monooxygenation of BP to inhibition by all primary metabolites, even though both reactions require the same enzyme, cytochrome P-450c.	Benzo(a)pyrene	107-109	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	204-221
6438082-8	1984	This difference probably reflects the much higher affinity of cytochrome P-450c for BP (Kd = 6 nM), as compared to 7,8-dihydrodiol (Kd = 175 nM) that was established spectrophotometrically both for the purified cytochrome and for MC microsomes.	Benzo(a)pyrene	84-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-79
6435901-5	1984	Whereas P-450b is only active in metabolism of DMBA (9.8 min-1 versus 1.9 min-1 for BP), P-450e has low activity for both substrates (3.3 and 1.2 min-1).	Benzo(a)pyrene	84-86	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	8-14
6435901-2	1984	The major 3-methylcholanthrene (MC) inducible cytochrome P-450 (form c) exhibits the greatest activity toward both benzo[a]pyrene (BP) (58 min-1) and 7,12-dimethylbenz[a]anthracene (DMBA) (29 min-1) and forms substantially high spin, high affinity complexes (Kd = 10 nM) with both hydrocarbons.	Benzo(a)pyrene	115-129	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	46-62
6488182-8	1984	Benzo(a)pyrene, 3-methylcholanthrene, and phenobarbital induce hepatic ALDH activity after treatment in vivo.	Benzo(a)pyrene	0-14	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	71-75
6435901-2	1984	The major 3-methylcholanthrene (MC) inducible cytochrome P-450 (form c) exhibits the greatest activity toward both benzo[a]pyrene (BP) (58 min-1) and 7,12-dimethylbenz[a]anthracene (DMBA) (29 min-1) and forms substantially high spin, high affinity complexes (Kd = 10 nM) with both hydrocarbons.	Benzo(a)pyrene	131-133	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	46-62
6088514-3	1984	Treatment of the cells with the polycyclic aromatic hydrocarbons, benzo(a)pyrene (BaP) or dimethylbenzanthracene, at concentrations which do not affect cell growth or macromolecular synthesis, stimulates the production of hCG in these cells.	Benzo(a)pyrene	66-80	chorionic gonadotropin subunit beta 5	Homo sapiens	222-225
6488182-11	1984	Treatment with benzo(a)pyrene (1.0 mM) also increases the NADP-dependent ALDH activity in both lines up to 17- and 48-fold, respectively.	Benzo(a)pyrene	15-29	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	73-77
6488182-12	1984	Treatment with 3-methylcholanthrene or benzo(a)pyrene increases ALDH activity 2-fold in HTC and JM2 but does not increase NADP-dependent ALDH activity in JM1.	Benzo(a)pyrene	39-53	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	64-68
6436235-1	1984	Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene.	Benzo(a)pyrene	88-102	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-40
6436235-8	1984	The activity, however, was restored to preparations from both PB-induced and 3-MC-induced mitochondrial enzymes (AFB1 activation, ethylmorphine, and benzphetamine deamination and BaP metabolism) by addition of purified rat liver cytochrome P-450 reductase, and beef adrenodoxin and adrenodoxin reductase.	Benzo(a)pyrene	179-182	cytochrome p450 oxidoreductase	Rattus norvegicus	229-255
6388822-8	1984	Results described in this report suggest that selenium modified the metabolism and hence the mutagenicity of BaP to TA100 by affecting mixed-function oxidase and/or epoxide hydratase activity in both the rat and hamster liver S9 activation systems.	Benzo(a)pyrene	109-112	epoxide hydrolase 2	Rattus norvegicus	165-182
6484988-8	1984	Intraperitoneal treatment with alpha-naphthoflavone (80 mg/kg) inhibited the oocyte destruction by io treatment with BP (10 micrograms/ovary) in both B6 and D2 mice.	Benzo(a)pyrene	117-119	defensin beta 2	Mus musculus	150-159
6088514-3	1984	Treatment of the cells with the polycyclic aromatic hydrocarbons, benzo(a)pyrene (BaP) or dimethylbenzanthracene, at concentrations which do not affect cell growth or macromolecular synthesis, stimulates the production of hCG in these cells.	Benzo(a)pyrene	82-85	chorionic gonadotropin subunit beta 5	Homo sapiens	222-225
6088514-5	1984	A concentration-dependent increase in the levels of mRNA alpha hCG sequences in BaP or dimethylbenzanthracene-treated ChaGo cells has been observed.	Benzo(a)pyrene	80-83	chorionic gonadotropin subunit beta 5	Homo sapiens	63-66
6088514-7	1984	A comparative study of the restriction endonuclease (MspI/HpaII) digestion patterns of the control and BaP-treated cell DNA suggests that the internal "C" residues of the -CCGG- sequences in the alpha hCG gene of untreated cells are highly methylated; whereas the internal C residues of the same MspI/HpaII recognition sequences in the alpha hCG gene are comparatively less methylated in BaP-treated cell DNA.	Benzo(a)pyrene	103-106	chorionic gonadotropin subunit beta 5	Homo sapiens	201-204
6088514-7	1984	A comparative study of the restriction endonuclease (MspI/HpaII) digestion patterns of the control and BaP-treated cell DNA suggests that the internal "C" residues of the -CCGG- sequences in the alpha hCG gene of untreated cells are highly methylated; whereas the internal C residues of the same MspI/HpaII recognition sequences in the alpha hCG gene are comparatively less methylated in BaP-treated cell DNA.	Benzo(a)pyrene	103-106	chorionic gonadotropin subunit beta 5	Homo sapiens	342-345
6088514-7	1984	A comparative study of the restriction endonuclease (MspI/HpaII) digestion patterns of the control and BaP-treated cell DNA suggests that the internal "C" residues of the -CCGG- sequences in the alpha hCG gene of untreated cells are highly methylated; whereas the internal C residues of the same MspI/HpaII recognition sequences in the alpha hCG gene are comparatively less methylated in BaP-treated cell DNA.	Benzo(a)pyrene	388-391	chorionic gonadotropin subunit beta 5	Homo sapiens	201-204
6487785-3	1984	Addition of the free radical scavenger 1,2,3-trioxybenzene and the monoxygenase substrate 3,4-benzo(a)pyrene to the incubation medium induces inhibition of LPO and simultaneous stabilization of cytochrome P-450.	Benzo(a)pyrene	90-108	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	194-210
6088105-9	1984	These results demonstrate that oxidation products of the peroxidation of lipids and fatty acids are able to react directly with benzo[a]pyrene to form products including benzo[a]pyrene quinones without the presence of enzymes such as the cytochrome P-450 mixed function oxidase system and prostaglandin synthetase.	Benzo(a)pyrene	128-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	238-254
6477826-1	1984	Arylhydrocarbon-hydroxylase (AHH) is a cytochrome P-450-dependent polysubstrate mono-oxygenase which plays an important role in converting some compounds (e.g. benzo[a]pyrene) to highly reactive carcinogenic species.	Benzo(a)pyrene	160-174	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-27
6477826-1	1984	Arylhydrocarbon-hydroxylase (AHH) is a cytochrome P-450-dependent polysubstrate mono-oxygenase which plays an important role in converting some compounds (e.g. benzo[a]pyrene) to highly reactive carcinogenic species.	Benzo(a)pyrene	160-174	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-55
6088883-0	1984	Reversibility of inhibition of interferon-alpha/beta induction by benzo[a]pyrene.	Benzo(a)pyrene	66-80	interferon alpha	Mus musculus	31-47
6488152-2	1984	The rate constant of the oxidation of BP was 9.5 X 10(4) M-1 sec-1.	Benzo(a)pyrene	38-40	secretory blood group 1, pseudogene	Homo sapiens	61-66
6090886-2	1984	Mouse liver cytosol contains saturable, high-affinity binding sites for the aromatic carcinogen benzo[a]pyrene that are distinct from the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding aryl hydrocarbon receptor.	Benzo(a)pyrene	96-110	aryl-hydrocarbon receptor	Mus musculus	189-214
6430544-8	1984	Among four forms of cytochrome P-450 examined, an isozyme P-448-IId which showed high activity in hydroxylation of benzo(a)pyrene catalyzed most efficiently the reduction of 1-nitropyrene.	Benzo(a)pyrene	115-129	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	20-36
6089190-1	1984	Mitogen-stimulated scheduled DNA synthesis and DNA excision repair in human lymphocytes, as well as DNA polymerase a activity in a cell-free system, were inhibited by an electrophilic metabolite of benzo[a]pyrene.	Benzo(a)pyrene	198-212	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	100-116
6516477-0	1984	[Aryl hydrocarbon hydroxylase in human lymphocytes: p-nitrophenetol as an alternative substrate to benzo(a)pyrene].	Benzo(a)pyrene	99-113	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	1-29
6487578-12	1984	It is proposed that a self-catalyzed inhibition (suicide inhibition) of the cytochrome P-450 dependent BP hydroxylation occurs in the presence of EP.	Benzo(a)pyrene	103-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	76-92
6437454-3	1984	Using antibodies against cytochrome P-448, the cytochrome P-448 content in native and reconstituted microsomal membranes and its participation in hydroxylation of benz(a)pyrene was determined.	Benzo(a)pyrene	163-176	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	47-63
6437454-4	1984	It was shown that benz(a)pyrene is hydroxylated in a membrane microsomal monooxygenase system more effectively, when the ratio of NADPH-cytochrome P-450 reductase to cytochrome P-448 is 1: 3 to 1: 6.	Benzo(a)pyrene	18-31	cytochrome p450 oxidoreductase	Rattus norvegicus	130-162
6437454-4	1984	It was shown that benz(a)pyrene is hydroxylated in a membrane microsomal monooxygenase system more effectively, when the ratio of NADPH-cytochrome P-450 reductase to cytochrome P-448 is 1: 3 to 1: 6.	Benzo(a)pyrene	18-31	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	166-182
6330212-7	1984	Kinetic studies in normal epidermis revealed that AHH reaction was linear up to 60 min and to 50 micrograms protein, had a pH optimum of 7.4, and the Km for BP was 0.62 microM.	Benzo(a)pyrene	157-159	aryl hydrocarbon receptor repressor	Homo sapiens	50-53
6087804-4	1984	Administration of very small doses of benzo[a]pyrene (50 micrograms/kg) to rats to induce cytochrome P-448 specifically increased only the O-de-ethylation of ethoxyresorufin.	Benzo(a)pyrene	38-52	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	90-106
6089701-6	1984	Inhaled DBP decreased in a dose-dependent way the lung microsomal concentration of cytochrome P-450 by as much as 63%, which was reflected in a significant reduction of the microsomal metabolism of n-hexane and benzo(a)pyrene in the 7.0 ppm group.	Benzo(a)pyrene	211-225	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-99
6087130-0	1984	Inhibition of the mutagenicity of benzo[a]pyrene in the V79/HGPRT system by bioantioxidants.	Benzo(a)pyrene	34-48	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	60-65
6438922-0	1984	Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene.	Benzo(a)pyrene	105-119	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	29-45
6327095-0	1984	Covalent binding of benzo[a]pyrene to cytochrome P-450 beta NF-B2 and other proteins in reconstituted mixed-function oxidase systems.	Benzo(a)pyrene	20-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	38-54
6331534-4	1984	Cytochrome P-450 (Mr = 51 000) elicits a low spin signal and reveals a high catalytic activity toward aminopyrine and a low catalytic activity toward benz(a)pyrene.	Benzo(a)pyrene	150-163	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
6327095-1	1984	A reconstituted mixed-function oxidase system, containing the major beta-naphthoflavone-induced isozyme of rat liver cytochrome P-450 bound benzo[a]pyrene covalently in the presence of NADPH.	Benzo(a)pyrene	140-154	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	117-133
6327095-5	1984	Approximately 6 molecules of benzo[a]pyrene bound to each molecule cytochrome P-450 during prolonged incubations.	Benzo(a)pyrene	29-43	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	67-83
6327095-6	1984	No binding occurred when the beta-naphthoflavone-induced isozyme of cytochrome P-450 was replaced by the major isozyme induced by phenobarbital, but both cytochromes incorporated benzo[a]pyrene to approximately the same extent when they were incubated together in the presence of the reductase and NADPH.	Benzo(a)pyrene	179-193	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84
6322977-0	1984	Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols.	Benzo(a)pyrene	11-25	aryl-hydrocarbon receptor	Mus musculus	59-70
6428468-4	1984	In the membranes reconstituted from the microsomes of the methylcholantrene-induced animals the catalytic activity of cytochrome P-448 in the metabolism of benz(a)pyrene at varying cytochrome P-448 and NADPH-cytochrome P-450 reductase contents were investigated.	Benzo(a)pyrene	156-169	cytochrome p450 oxidoreductase	Homo sapiens	202-234
6326866-1	1984	Using antibodies against electrophoretically homogeneous cytochrome P-448 from rat liver microsomes induced by 3-methylcholanthrene, the changes in the immunologic identity and contents by cytochrome P-448 induced by 3-methylcholanthrene, 3.4-benzpyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were studied.	Benzo(a)pyrene	239-253	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	189-205
6326866-4	1984	On the other hand, 3-methylcholanthrene, 3,4-benzpyrene and TCDD significantly and equally activates the cytochrome P-448-dependent benzpyrene hydroxylase, since the antibodies against cytochrome P-448 inhibit benzpyrene metabolism in the microsomes by 85-90%.	Benzo(a)pyrene	41-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	105-121
6326866-4	1984	On the other hand, 3-methylcholanthrene, 3,4-benzpyrene and TCDD significantly and equally activates the cytochrome P-448-dependent benzpyrene hydroxylase, since the antibodies against cytochrome P-448 inhibit benzpyrene metabolism in the microsomes by 85-90%.	Benzo(a)pyrene	41-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	185-201
6326866-5	1984	The possible reasons for the TCDD-induced increase in the catalytic activity of cytochrome P-448 as compared to the immunologically identical cytochrome P-448 induced by 3-methylcholanthrene and 3,4-benzpyrene, are discussed.	Benzo(a)pyrene	195-209	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-96
6326866-5	1984	The possible reasons for the TCDD-induced increase in the catalytic activity of cytochrome P-448 as compared to the immunologically identical cytochrome P-448 induced by 3-methylcholanthrene and 3,4-benzpyrene, are discussed.	Benzo(a)pyrene	195-209	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-158
6427199-8	1984	In a reconstituted system containing NADPH and NADPH-cytochrome P-450 reductase, PB-1 and PB-2 oxidized benzphetamine at high rates, but their oxidation of benzo(a)pyrene was much slower than that by MC-1, which catalyzed rapid hydroxylation of benzo(a)pyrene but had low activity with benzphetamine.	Benzo(a)pyrene	156-170	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	81-94
6427199-8	1984	In a reconstituted system containing NADPH and NADPH-cytochrome P-450 reductase, PB-1 and PB-2 oxidized benzphetamine at high rates, but their oxidation of benzo(a)pyrene was much slower than that by MC-1, which catalyzed rapid hydroxylation of benzo(a)pyrene but had low activity with benzphetamine.	Benzo(a)pyrene	245-259	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	81-94
6322386-7	1984	On the contrary we have observed an inhibition of B[a]P metabolism by 6a-chrysene, which can reach 80% of the aryl hydrocarbon hydroxylase (AHH) activity when 6a-chrysene remains constant in the cells.	Benzo(a)pyrene	50-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	110-138
6198465-7	1984	The susceptibilities to cleavage of the Arg-X bonds in the BP can be explained with varying degrees of success in terms of the known specificity of thrombin.	Benzo(a)pyrene	59-61	prothrombin	Oryctolagus cuniculus	148-156
6317167-5	1984	Since the gross microsomal cytochrome P-450 content was not significantly affected by the treatment, the change of regioselectivity in BP metabolism was probably due to the alteration of cytochrome P-450 isozyme composition by dietary BHA.	Benzo(a)pyrene	135-137	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	187-203
6418404-3	1984	Relative to the mutant frequencies determined with control liver homogenates, induction of IFN-gamma depressed the abilities of homogenates from treated animals to activate N-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), and benzo[a]pyrene (BP) by 55%, 44% and 95%, respectively.	Benzo(a)pyrene	227-241	interferon gamma	Mus musculus	91-100
6418404-3	1984	Relative to the mutant frequencies determined with control liver homogenates, induction of IFN-gamma depressed the abilities of homogenates from treated animals to activate N-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), and benzo[a]pyrene (BP) by 55%, 44% and 95%, respectively.	Benzo(a)pyrene	243-245	interferon gamma	Mus musculus	91-100
6418404-5	1984	In vivo induction of IFN-gamma suppressed the Aroclor 1254-dependent increases in mutagenesis by AAF (63%), AFB1 (90%), and BP (reduced to a level 23% below non-Aroclor 1254 treatment).	Benzo(a)pyrene	124-126	interferon gamma	Mus musculus	21-30
6201907-7	1984	Consideration of the temporal and immunochemical relationships as well as of the differential diagnosis provides a basis for the understanding of the significance of BP, its antibodies and other immunoglobulins in the CSF.	Benzo(a)pyrene	166-168	colony stimulating factor 2	Homo sapiens	218-221
6440265-6	1984	This behavior of G6PD-deficient HL and HSF is coupled with an increase of the resistance to the cell death induced by benzo(a)pyrene (BP).	Benzo(a)pyrene	118-132	interleukin 6	Homo sapiens	39-42
6440265-6	1984	This behavior of G6PD-deficient HL and HSF is coupled with an increase of the resistance to the cell death induced by benzo(a)pyrene (BP).	Benzo(a)pyrene	134-136	interleukin 6	Homo sapiens	39-42
6087560-1	1984	The study was concerned with benzo(a)pyrene (BP) mutagenicity tests involving induction of direct genetic mutations in hypoxanthin-guanine phosphoribosyl transferase (HGPRT) loci in Chinese hamster cells V-79.	Benzo(a)pyrene	29-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	119-165
6087560-1	1984	The study was concerned with benzo(a)pyrene (BP) mutagenicity tests involving induction of direct genetic mutations in hypoxanthin-guanine phosphoribosyl transferase (HGPRT) loci in Chinese hamster cells V-79.	Benzo(a)pyrene	29-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	167-172
6087560-1	1984	The study was concerned with benzo(a)pyrene (BP) mutagenicity tests involving induction of direct genetic mutations in hypoxanthin-guanine phosphoribosyl transferase (HGPRT) loci in Chinese hamster cells V-79.	Benzo(a)pyrene	45-47	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	119-165
6087560-1	1984	The study was concerned with benzo(a)pyrene (BP) mutagenicity tests involving induction of direct genetic mutations in hypoxanthin-guanine phosphoribosyl transferase (HGPRT) loci in Chinese hamster cells V-79.	Benzo(a)pyrene	45-47	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	167-172
6087560-6	1984	In vitro and in vivo evaluation of BP mutagenicity was carried out in V-79/HGPRT system after Wood et al (1976).	Benzo(a)pyrene	35-37	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	75-80
6326392-1	1984	The mechanistic plurality of the microsomal cytochrome P-450 enzyme system is illustrated by studies of the oxidative metabolism of benzo[a]pyrene, 3-hydroxybenzo[a]pyrene and arachidonic acid.	Benzo(a)pyrene	132-146	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
6326393-16	1984	Equilibrium gel filtration analysis of the number of benzo[a]pyrene binding sites per mole of enzyme monomer showed a value of 1 for purified yeast cytochrome P-448 and 6 for this enzyme in microsomal form.	Benzo(a)pyrene	53-67	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	148-164
6326393-18	1984	However, purified cytochrome P-448 from beta-naphthoflavone-induced rats gave a value of 6 benzo[a]pyrene binding sites.	Benzo(a)pyrene	91-105	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	18-34
6326393-19	1984	Type I binding spectra with purified yeast cytochrome P-448 were observed with benzo[a]pyrene, lanosterol, ethylmorphine, dimethylnitrosamine, sodium phenobarbitone and perhydrofluorene.	Benzo(a)pyrene	79-93	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	43-59
6318770-8	1983	Also in the responsive strains, induction of AFB1-4-hydroxylase activity was strongly associated with (a) the depression of the mutagenic activation of AFB1, and (b) with the induction of both AHH and the mutagenic activation of benzo[a]pyrene.	Benzo(a)pyrene	229-243	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	193-196
6140086-1	1983	Feeding male Fischer F-344 rats for 5 weeks a diet containing 1% orotic acid, a precursor for pyrimidine nucleotide biosynthesis, resulted in an increased incidence of gamma-glutamyltransferase (EC 2.3.2.2) positive foci induced by chemical carcinogens including 1,2-dimethylhydrazine, diethylnitrosamine, benzo[a]pyrene, and aflatoxin B1.	Benzo(a)pyrene	306-320	gamma-glutamyltransferase 1	Rattus norvegicus	168-193
6315393-2	1983	Constitutive activity of microsomal aryl hydrocarbon hydroxylase (AHH) (benzo(a)pyrene substrate) was monitored in lung and liver homogenates up to 10 days after exposure.	Benzo(a)pyrene	72-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	36-64
6315393-2	1983	Constitutive activity of microsomal aryl hydrocarbon hydroxylase (AHH) (benzo(a)pyrene substrate) was monitored in lung and liver homogenates up to 10 days after exposure.	Benzo(a)pyrene	72-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	66-69
6319113-5	1983	The rates of individual BaP metabolite production are increased in lungs from mice pretreated with Aroclor 1254 or beta-naphthoflavone, substances known to induce increased synthesis of cytochrome P-450.	Benzo(a)pyrene	24-27	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	186-202
6319113-7	1983	These results support the existence of significant cytochrome P-450-dependent and conjugative BaP metabolism in the intact mouse lung, similar to that examined in other species, and capable of contributing to the systemic metabolism of this carcinogen.	Benzo(a)pyrene	94-97	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	51-67
6315254-10	1983	The total formation of BP conjugates was 42% higher in B6 hepatocytes than in those of C3 strain.	Benzo(a)pyrene	23-25	complement component 3	Mus musculus	87-89
6315254-12	1983	Simultaneously, 2.5-fold higher accumulation of unconjugated BP metabolites was observed in the hepatocyte suspension of B6 than C3 strain and a 1.4-fold higher activity of aryl hydrocarbon hydroxylase in hepatic microsomes of this strain.	Benzo(a)pyrene	61-63	complement component 3	Mus musculus	129-131
6636190-2	1983	The cytosolic epoxide hydrolase activity was routinely monitored with trans-beta-ethylstyrene oxide, the microsomal epoxide hydrolase activity with benzo(a)pyrene, 4,5-oxide, and the glutathione S-transferase activity with 2,4-dichloro-4-nitrobenzene.	Benzo(a)pyrene	148-162	epoxide hydrolase 2, cytoplasmic	Mus musculus	4-31
6314905-0	1983	Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450.	Benzo(a)pyrene	65-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	137-153
6309378-6	1983	Benzo(a)pyrene was metabolized by AHH to dihydrodiols, quinones, and phenols in quantities which were about 10 times greater than those reported for rat lung microsomes.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	34-37
6626210-1	1983	The filamentous fungus Aspergillus ochraceus TS produces an inducible microsomal cytochrome P-450 linked monooxygenase which is capable of hydroxylating benzo(a)pyrene in presence of O2 and NADPH.	Benzo(a)pyrene	153-167	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-97
6626210-5	1983	These findings together with the results obtained with flavone on the metabolism of benzo(a)pyrene by various microsomal preparations suggest a parallel induction of multiple forms of cytochrome P-450 as observed in mammalian liver under identical condition.	Benzo(a)pyrene	84-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	184-200
6629771-2	1983	The carcinogen benzo(a)pyrene is present in most coal tar preparations, and it is a potent inducer of the aryl hydrocarbon hydroxylase activity in liver and skin after topical application.	Benzo(a)pyrene	15-29	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	106-134
6629771-3	1983	The formation of the most reactive metabolite of benzo(a)pyrene is catalyzed by aryl hydrocarbon hydroxylase hydroxylase.	Benzo(a)pyrene	49-63	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	80-108
6305488-0	1983	Immunochemical study on the contributions of two molecular species of microsomal cytochrome P-450 to the metabolism of benzo(a)pyrene by rat liver microsomes.	Benzo(a)pyrene	119-133	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	81-97
6085224-5	1984	The amount of BP-like material that enters CSF and cross-reacts with BP peptide 43-88 is related to the recognition of an epitope or epitopes in the C-terminal portion of this peptide.	Benzo(a)pyrene	14-16	colony stimulating factor 2	Homo sapiens	43-46
6085224-5	1984	The amount of BP-like material that enters CSF and cross-reacts with BP peptide 43-88 is related to the recognition of an epitope or epitopes in the C-terminal portion of this peptide.	Benzo(a)pyrene	69-71	colony stimulating factor 2	Homo sapiens	43-46
6305488-2	1983	Benzo(a)pyrene was incubated with polychlorinated biphenyl-treated rat liver microsomes, in which PB-P-450 and MC-P-448 constituted about 45 and 24% of the total cytochrome P-450, respectively.	Benzo(a)pyrene	0-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	162-178
6308439-6	1983	Treatment of CHO cells with a number of mutagenic agents e.g. ethyl methanesulfonate, ICR170, ultraviolet light, and benzo[a]pyrene, led to a nearly linear concentration-dependent increase in the frequency of the AK- mutants in cultures.	Benzo(a)pyrene	117-131	adenosine kinase	Cricetulus griseus	213-215
6136322-1	1983	Treatment of adult female rats with a single dose of benzo[a]pyrene (BaP) fails to initiate preneoplastic enzyme-altered islands in their livers.	Benzo(a)pyrene	53-67	prohibitin 2	Rattus norvegicus	69-72
6623311-1	1983	Fifty-four benzo[a]pyrene (BP)-resistant, aryl hydrocarbon hydroxylase (AHH)-deficient mutants were found to be recessive, while five were dominant.	Benzo(a)pyrene	11-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	72-75
6312638-3	1983	Glucuronic acid conjugates of BP 4,5-diol, BP 1,6-, 3,6- and 6,12-quinones were detected in rat bile with low levels of 3- and 9-OH BP and BP 7,8- and 9,10-diols.	Benzo(a)pyrene	30-32	Blood pressure QTL 7	Rattus norvegicus	139-152
6303564-6	1983	Amounts of BP diol-epoxide I-derived tetrols formed from BP-7,8-diol by the prostaglandin synthetase-dependent and the cytochrome P-450-dependent pathways varied significantly between the two pulmonary cell fractions examined.	Benzo(a)pyrene	11-13	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	119-135
6885735-5	1983	In reconstituted systems, pulmonary P-450MC efficiently catalyzed benzo(a)pyrene hydroxylation and ethoxycoumarin O-deethylation, but showed a low activity for benzphetamine N-demethylation.	Benzo(a)pyrene	66-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	36-43
6885735-7	1983	The pulmonary and hepatic P-450MC activities of benzo(a)pyrene hydroxylation and ethoxycoumarin O-deethylation were inhibited in the same manner by the antibody against hepatic P-450MC.	Benzo(a)pyrene	48-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	26-33
6885735-7	1983	The pulmonary and hepatic P-450MC activities of benzo(a)pyrene hydroxylation and ethoxycoumarin O-deethylation were inhibited in the same manner by the antibody against hepatic P-450MC.	Benzo(a)pyrene	48-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	177-184
6622818-2	1983	Pretreatment of rats with 3,4-benzpyrene or phenobarbital increased the liver microsomal concentration of cytochrome P-450 (448) and the rate of aminopyrine and p-nitroanisole demethylation and of aniline hydroxylation whereas pretreatment cytochrome P-450 depressor agents such as cadmium or cobalt lowered the concentration of the hemoprotein and decreased the rate of the demethylation reactions.	Benzo(a)pyrene	26-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	106-122
6622818-2	1983	Pretreatment of rats with 3,4-benzpyrene or phenobarbital increased the liver microsomal concentration of cytochrome P-450 (448) and the rate of aminopyrine and p-nitroanisole demethylation and of aniline hydroxylation whereas pretreatment cytochrome P-450 depressor agents such as cadmium or cobalt lowered the concentration of the hemoprotein and decreased the rate of the demethylation reactions.	Benzo(a)pyrene	26-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	240-256
6683474-1	1983	It is possible to assay for trans-7,8-dihydroxy 7,8-dihydrobenzo[a]-pyrene (BP-7,8-dihydrodiol) in complex metabolite mixtures produced during microsomal metabolism of benzo[a]pyrene (BP) because only the BP-7,8-dihydrodiol metabolite will produce significant chemiluminescence (CL) in the NaOCl-H2O2 singlet oxygen-generating system.	Benzo(a)pyrene	168-182	BP7	Homo sapiens	76-80
6683474-1	1983	It is possible to assay for trans-7,8-dihydroxy 7,8-dihydrobenzo[a]-pyrene (BP-7,8-dihydrodiol) in complex metabolite mixtures produced during microsomal metabolism of benzo[a]pyrene (BP) because only the BP-7,8-dihydrodiol metabolite will produce significant chemiluminescence (CL) in the NaOCl-H2O2 singlet oxygen-generating system.	Benzo(a)pyrene	76-78	BP7	Homo sapiens	205-209
6187818-1	1983	Complement-mediated lysis of reconstituted lipid-myelin basic protein (BP) vesicles and myelin vesicles due to antibody raised against BP and isolated myelin is measured by determination of the amount of a water-soluble spin label, tempocholine chloride, released from the vesicles.	Benzo(a)pyrene	71-73	myelin basic protein	Homo sapiens	49-69
6830852-1	1983	Cytochrome P-450 substrate interactions were studied with cytochrome P-450 partially purified from livers of untreated, phenobarbital-treated, benzo[a]pyrene-treated and caffeine-treated rats.	Benzo(a)pyrene	143-157	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
6298084-2	1983	We examined the relationship between the ability of I-3-C to alter the activity of hepatic aryl hydrocarbon hydroxylase (AHH), and its ability to inhibit the covalent binding of benzo[a]pyrene (BaP) metabolites to DNA and protein.	Benzo(a)pyrene	178-192	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-124
6298084-3	1983	Using an in vitro system and a hepatic postmitochondrial fraction from mice that had been treated by gavage with I-3-C, we found that up to 90% of the covalent binding of BaP metabolites to macromolecules was eliminated, while AHH activity was unchanged.	Benzo(a)pyrene	171-174	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	227-230
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	117-120
6295661-0	1983	Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1.	Benzo(a)pyrene	82-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
6295661-4	1983	However, only cytochrome P-448(55) metabolizes benzo[a]pyrene and its 7,8-dihydrodiol derivative to mutagenic products.	Benzo(a)pyrene	47-61	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	14-30
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
6307537-2	1983	With single doses of B[a]P or 1,2-DMH during the feeding of the CLD diet for 3 weeks, the number of foci of hepatocytes positive for gamma-glutamyl transferase is approximately the same as with the same dose of each carcinogen given after partial hepatectomy.	Benzo(a)pyrene	21-26	gamma-glutamyltransferase 1	Rattus norvegicus	133-159
6191918-4	1983	The two P-448 forms had similar spectral properties, substrate specificity, sensitivity to inhibitors and regioselectivity in the metabolism of benzo(a)pyrene and testosterone.	Benzo(a)pyrene	144-158	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	8-13
6189709-2	1983	The action of benzo(a)pyrene, 3-methylcholanthrene and 7,12-dimethylbenzo(a)anthracene in the activity of the rat thymus D-T diaphorase (EC 1.6.99.2) and the NAD(P)H cytochrome C (EC 1.6.99.3) reductases of particulate fractions were studied in intact and adrenalectomized animals.	Benzo(a)pyrene	14-28	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	121-135
6300414-7	1983	Anti-NGF treatment of rats (178) and mice (179) can alter the tumor distribution observed following ethylnitrosourea or benzo(a)pyrene treatment (10).	Benzo(a)pyrene	120-134	nerve growth factor	Rattus norvegicus	5-8
6135167-0	1983	Induction of gamma-glutamyl transpeptidase positive cells by benzo(a)pyrene in embryonic rat tongue cells in culture.	Benzo(a)pyrene	61-75	gamma-glutamyltransferase 1	Rattus norvegicus	13-42
6290035-2	1982	The BP bound to the carcinogen-binding protein (CBP) was exchangeable in a time- and temperature-dependent fashion and has a Kd of 1.8 X 10(-9) M. Competitive binding studies indicate that chemical carcinogens [3-methylcholanthrene, benz(a)anthracene, dibenz(a,c)anthracene] and other inducers of aryl hydrocarbon hydroxylase (5,6- and 7,8-benzoflavone) compete to varying degrees with BP for binding.	Benzo(a)pyrene	4-6	CREB binding protein	Mus musculus	20-46
6290035-2	1982	The BP bound to the carcinogen-binding protein (CBP) was exchangeable in a time- and temperature-dependent fashion and has a Kd of 1.8 X 10(-9) M. Competitive binding studies indicate that chemical carcinogens [3-methylcholanthrene, benz(a)anthracene, dibenz(a,c)anthracene] and other inducers of aryl hydrocarbon hydroxylase (5,6- and 7,8-benzoflavone) compete to varying degrees with BP for binding.	Benzo(a)pyrene	4-6	CREB binding protein	Mus musculus	48-51
6290035-2	1982	The BP bound to the carcinogen-binding protein (CBP) was exchangeable in a time- and temperature-dependent fashion and has a Kd of 1.8 X 10(-9) M. Competitive binding studies indicate that chemical carcinogens [3-methylcholanthrene, benz(a)anthracene, dibenz(a,c)anthracene] and other inducers of aryl hydrocarbon hydroxylase (5,6- and 7,8-benzoflavone) compete to varying degrees with BP for binding.	Benzo(a)pyrene	49-51	CREB binding protein	Mus musculus	20-46
6290039-3	1982	A significant increase in the hypoxanthine-guanine phosphoribosyltransferase mutation frequency was induced when 10 to 100 microM BP was added to the cocultures.	Benzo(a)pyrene	130-132	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	30-76
7126636-4	1982	Two of these fractions had similar properties and significantly metabolized [14C]benzo[a]pyrene in a reconstituted system containing rat cytochrome P-450 reductase.	Benzo(a)pyrene	81-95	cytochrome p450 oxidoreductase	Rattus norvegicus	137-163
7120116-3	1982	In vitro treatment of the cells or in vivo application to the skin of animals with the polycyclic aromatic hydrocarbons benz(a)anthracene (BA) or benzo(a)pyrene resulted in significant induction of AHH and 7-ED activities.	Benzo(a)pyrene	146-160	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	198-201
7142127-10	1982	It catalyzed benzo(a)pyrene hydroxylation with a turnover rate of 3.63 nmol/nmol of cytochrome P-450 in a reconstituted system containing NADPH-cytochrome c reductase and phosphatidylcholine, whereas little myristate hydroxylation activity was detected.	Benzo(a)pyrene	13-27	cytochrome P-450	Oryctolagus cuniculus	84-100
7126636-6	1982	Purified cytochromes P-448 from 3-methylcholanthrene-treated rat had similar spectral properties and activity towards [14C]benzo[a]pyrene suggesting similarities between these forms.	Benzo(a)pyrene	123-137	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-26
6286155-1	1982	Hexachlorobenzene (HCB) produced increases in ethoxyresorufin (ERR) O-deethylase, aryl hydrocarbon hydroxylase (AHH) and aminopyrine N-demethylase activities in rat liver phenobarbital which were intermediate between those produced by phenobarbital and 3,4-benzpyrene (BP), alpha-Naphthoflavone (ANF) selectivity inhibited ERR activity in BP and HCB-induced microsomes (94% and 88%).	Benzo(a)pyrene	269-271	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	112-115
6286155-1	1982	Hexachlorobenzene (HCB) produced increases in ethoxyresorufin (ERR) O-deethylase, aryl hydrocarbon hydroxylase (AHH) and aminopyrine N-demethylase activities in rat liver phenobarbital which were intermediate between those produced by phenobarbital and 3,4-benzpyrene (BP), alpha-Naphthoflavone (ANF) selectivity inhibited ERR activity in BP and HCB-induced microsomes (94% and 88%).	Benzo(a)pyrene	339-341	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	112-115
7127220-7	1982	These differences in IC50 values indicated that the predominant form(s) of cytochrome P-450 that hydroxylate benzo(a)pyrene varied with the age, hormonal, and induced status of the animal.	Benzo(a)pyrene	109-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	75-91
6177781-6	1982	Irrespective of whether donors received BP in IFA or CFA, BP-cultured spleen and lymph node cells (SpC and LNC, respectively) transferred EAE, whereas Con A-cultured SpC but not LNC exhibited effector cell activity.	Benzo(a)pyrene	58-60	sparse coat	Mus musculus	99-102
7121490-1	1982	The effect of expression time (the time between the end of the treatment period and the first exposure to selective medium) on the frequency of benzo[a]pyrene (BP)-induced mutations at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase 2.4.2.8) locus was examined in the cell-mediated mutation assay in which V79 Chinese hamster cells are the targets and BP activation is mediated by Syrian hamster embryo cells.	Benzo(a)pyrene	144-158	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	189-194
7121490-1	1982	The effect of expression time (the time between the end of the treatment period and the first exposure to selective medium) on the frequency of benzo[a]pyrene (BP)-induced mutations at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase 2.4.2.8) locus was examined in the cell-mediated mutation assay in which V79 Chinese hamster cells are the targets and BP activation is mediated by Syrian hamster embryo cells.	Benzo(a)pyrene	160-162	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	189-194
6182644-1	1982	Administration of the carcinogens, benzo[a]pyrene and 1,2-benzanthracene, increased UDP glucuronosyltransferase activities towards 4-nitrophenol, 3-hydroxybenzo[a]pyrene, 7-hydroxycoumarin and 1-naphthol to a greater extent than did pretreatment with the noncarcinogens, anthracene and phenanthrene.	Benzo(a)pyrene	35-49	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	84-111
6282475-1	1982	NADPH-reduction of benzo[a]pyrene 4,5-oxide (BP-4,5-oxide) to BP required four components from rat liver: cytochrome P-450, NADPH cytochrome P-450 reductase, phosphatidylcholine and a soluble, heat-sensitive factor which was present in 105 000 X g supernatant and was also released from microsomes by sonication.	Benzo(a)pyrene	45-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	106-122
6282475-1	1982	NADPH-reduction of benzo[a]pyrene 4,5-oxide (BP-4,5-oxide) to BP required four components from rat liver: cytochrome P-450, NADPH cytochrome P-450 reductase, phosphatidylcholine and a soluble, heat-sensitive factor which was present in 105 000 X g supernatant and was also released from microsomes by sonication.	Benzo(a)pyrene	45-47	cytochrome p450 oxidoreductase	Rattus norvegicus	124-156
6287251-0	1982	Mutagenicity of benzo[a]pyrene and the antioxidant phenol at the HGPRT locus of V79 chinese hamster cells.	Benzo(a)pyrene	16-30	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	65-70
6180437-11	1982	(ii) BP is added to the myelin sheath prior to PLP and there appears to be a shift in priority of synthesis from BP to PLP in individual oligodendrocytes during the process of myelination.	Benzo(a)pyrene	5-7	proteolipid protein 1	Homo sapiens	119-122
6288047-4	1982	RJ inhibited the microsomal oxidation of substrates of cytochrome P-450 (aniline, aminopyrine and benzo [a]pyrene).	Benzo(a)pyrene	98-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	55-71
6177712-2	1982	As studied by double antibody radioimmunoassay, exposure of bovine brain myelin basic protein to bovine brain cathepsin D led to the appearance of an antigenic determinant recognized by an antibody reactive predominantly with the molecular region of BP encompassing residues 79-88.	Benzo(a)pyrene	250-252	myelin basic protein	Bos taurus	73-93
6177712-2	1982	As studied by double antibody radioimmunoassay, exposure of bovine brain myelin basic protein to bovine brain cathepsin D led to the appearance of an antigenic determinant recognized by an antibody reactive predominantly with the molecular region of BP encompassing residues 79-88.	Benzo(a)pyrene	250-252	cathepsin D	Bos taurus	110-121
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	53-67	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	109-137
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	53-67	chloride intracellular channel 4	Homo sapiens	150-155
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	53-67	chloride intracellular channel 4	Homo sapiens	350-355
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	294-308	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	109-137
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	294-308	chloride intracellular channel 4	Homo sapiens	150-155
6125353-8	1982	Analysis also were performed on the relationships of E2 2- and 4-hydroxylations to BaP metabolism as assessed with high-pressure liquid chromatography (HPLC).	Benzo(a)pyrene	83-86	transcription factor 4	Homo sapiens	53-64
6174621-3	1982	We recently demonstrated that Lewis rats immunized with bacterial lipopolysaccharides (LPS) precomplexed to guinea pig myelin basic protein (BP) in complete Freund"s adjuvant were less effective in inducing experimental allergic encephalomyelitis (EAE) than BP-immunized controls.	Benzo(a)pyrene	141-143	myelin basic protein	Cavia porcellus	119-139
6285672-0	1982	Interindividual variation in benzo(a)pyrene metabolism and composition of isoenzymes of cytochrome P-450 as revealed by SDS-gel electrophoresis of human liver microsomal fractions.	Benzo(a)pyrene	29-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	88-104
6800653-2	1982	Both 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene, which also is a well-known carcinogen but has no short-term effects on rat adrenals, appear to be metabolized by one common type of cytochrome P-450-dependent monooxygenase localized in the endoplasmic reticulum.	Benzo(a)pyrene	40-54	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	188-204
7057055-4	1982	Among several defined constituents of coal tar tested benzo(a)pyrene (BP), anthracene and acridine were found to have measurable induction effects on neonatal rat skin and liver AHH.	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	178-181
7057055-4	1982	Among several defined constituents of coal tar tested benzo(a)pyrene (BP), anthracene and acridine were found to have measurable induction effects on neonatal rat skin and liver AHH.	Benzo(a)pyrene	70-72	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	178-181
6280710-0	1982	Effects of estrogens on aryl hydrocarbon hydroxylase mediated binding of benzo(a) pyrene metabolites to DNA in vitro.	Benzo(a)pyrene	73-88	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-52
7056021-1	1982	The induced activity of aryl hydrocarbon hydroxylase (AHH), measured by the metabolism of benzo[a]pyrene to fluorescent products in cultured human lymphocytes, shows a strong seasonal variation.	Benzo(a)pyrene	90-104	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	24-52
7056021-1	1982	The induced activity of aryl hydrocarbon hydroxylase (AHH), measured by the metabolism of benzo[a]pyrene to fluorescent products in cultured human lymphocytes, shows a strong seasonal variation.	Benzo(a)pyrene	90-104	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	54-57
6172517-1	1982	Myelin basic protein (BP) emulsified in incomplete Freund"s adjuvant (BP/IFA) is relatively nonencephalitogenic in Lewis rats.	Benzo(a)pyrene	22-24	myelin basic protein	Rattus norvegicus	0-20
6279326-7	1982	The total metabolism of BP was found to be approximately 20-fold greater with the cytochrome P-450 from the 3-methylcholanthrene (P-450 3-MC) and beta-naphthoflavone (P-450 BNF) treated rats than with the phenobarbital preinduced cytochrome P-450 (P-450 BP).	Benzo(a)pyrene	24-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	82-98
6279326-7	1982	The total metabolism of BP was found to be approximately 20-fold greater with the cytochrome P-450 from the 3-methylcholanthrene (P-450 3-MC) and beta-naphthoflavone (P-450 BNF) treated rats than with the phenobarbital preinduced cytochrome P-450 (P-450 BP).	Benzo(a)pyrene	24-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	230-246
6284402-0	1982	Benzo[a]pyrene and other inducers of cytochrome P1-450 inhibit binding of epidermal growth factor to cell surface receptors.	Benzo(a)pyrene	0-14	epidermal growth factor	Mus musculus	74-97
6284402-2	1982	Exposure of confluent C3H 10T1/2 mouse fibroblasts to 1 muM benzo[a]pyrene led to a time-dependent decrease of EGF binding.	Benzo(a)pyrene	60-74	epidermal growth factor	Mus musculus	111-114
7172416-1	1982	Administration of a single dose of the inhibitor of the hepatic mixed function oxidases, 9-hydroxyellipticine (9-OHE), resulted in a marked increase in the cytochrome P-448 catalysed activities of ethoxyresorufin O-deethylase, biphenyl 2-hydroxylase and activation of benzo[a]pyrene to mutagens.	Benzo(a)pyrene	268-282	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	156-172
6813677-3	1982	The first class bound, precipitated, and inhibited the enzyme activity of P-450LM2 for both benzo[a]pyrene hydroxylation and 7-ethoxycoumarin deethylation.	Benzo(a)pyrene	92-106	cytochrome P450 2B4	Oryctolagus cuniculus	74-82
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	13-27	glucuronidase, beta	Rattus norvegicus	96-114
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	13-27	glucuronidase, beta	Rattus norvegicus	116-125
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	13-27	galactosidase, beta 1	Rattus norvegicus	128-146
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	13-27	galactosidase, beta 1	Rattus norvegicus	148-156
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	29-31	glucuronidase, beta	Rattus norvegicus	96-114
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	29-31	glucuronidase, beta	Rattus norvegicus	116-125
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	29-31	galactosidase, beta 1	Rattus norvegicus	128-146
6805101-2	1982	injection of benzo(a)pyrene (BP; 10 mg/kg) into rats led to the progressive release of hepatic, beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal) and beta-N-acetylglucosaminidase (beta-Glm).	Benzo(a)pyrene	29-31	galactosidase, beta 1	Rattus norvegicus	148-156
6805101-4	1982	The in vitro studies on the latency of beta-Gluc, Beta-Gal and beta-Glm in the lysosome-enriched rat liver suspension treated with BP showed that concentrations of 10(-7) M, 10(-6) M and 10(-5) M significantly decrease latency of all three lysosomal enzymes, the effect being time-dependent.	Benzo(a)pyrene	131-133	glucuronidase, beta	Rattus norvegicus	39-48
6275873-3	1981	In this respect lung AHH behaves completely differently from the liver and kidney enzyme, in which organs, basal AHH activity (which is low in the foetus) increases rapidly after birth to reach the adult level 2 months later, and is only inducible by CSC and low doses of BP in unweaned rats.	Benzo(a)pyrene	272-274	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	113-116
6270135-2	1981	Benzo[a]pyrene metabolism was stimulated more than 5-fold by the addition of 600 microM flavone to a reconstituted monooxygenase system consisting of NADPH, cytochrome P-450 reductase, dilauroylphosphatidylcholine, and cytochrome P-450LM3c or cytochrome P-450LM4.	Benzo(a)pyrene	0-14	cytochrome P450 1A2	Oryctolagus cuniculus	243-262
6270135-3	1981	In contrast, an inhibitory effect of flavone on benzo[a]pyrene metabolism was observed when cytochrome P-450LM2, cytochrome P-450LM3b, or cytochrome P-450LM6 was used in the reconstituted system.	Benzo(a)pyrene	48-62	cytochrome P450 2B4	Oryctolagus cuniculus	92-111
6270135-3	1981	In contrast, an inhibitory effect of flavone on benzo[a]pyrene metabolism was observed when cytochrome P-450LM2, cytochrome P-450LM3b, or cytochrome P-450LM6 was used in the reconstituted system.	Benzo(a)pyrene	48-62	cytochrome P450 1A1	Oryctolagus cuniculus	138-157
6270135-4	1981	7,8-Benzoflavone (50-100 microM) stimulated benzo[a]pyrene metabolism by the reconstituted monooxygenase system about 10-fold when cytochrome P-450LM3c was used, but benzo[a]pyrene hydroxylation was strongly inhibited when 7,8-benzoflavone was added to the cytochrome P-450LM6-dependent system.	Benzo(a)pyrene	44-58	cytochrome P450 1A1	Oryctolagus cuniculus	257-276
6270135-5	1981	Smaller effects of 7,8-benzoflavone were observed on the metabolism of benzo[a]pyrene by the cytochrome P-450LM2-, cytochrome P-450LM3b-, and cytochrome P-450LM4-dependent monooxygenase systems.	Benzo(a)pyrene	71-85	cytochrome P450 2B4	Oryctolagus cuniculus	93-112
6270135-5	1981	Smaller effects of 7,8-benzoflavone were observed on the metabolism of benzo[a]pyrene by the cytochrome P-450LM2-, cytochrome P-450LM3b-, and cytochrome P-450LM4-dependent monooxygenase systems.	Benzo(a)pyrene	71-85	cytochrome P450 1A2	Oryctolagus cuniculus	142-161
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	56-70	catechol-O-methyltransferase	Homo sapiens	128-156
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	56-70	catechol-O-methyltransferase	Homo sapiens	158-162
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	72-74	catechol-O-methyltransferase	Homo sapiens	128-156
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	72-74	catechol-O-methyltransferase	Homo sapiens	158-162
6272977-3	1981	Approximately 0.06% of substrate BP was recovered as COMT/SAM-reactive substances.	Benzo(a)pyrene	33-35	catechol-O-methyltransferase	Homo sapiens	53-57
6272977-5	1981	Organic extracts of COMT/[14C]SAM incubations with BP were fractionated by high-performance liquid chromatography.	Benzo(a)pyrene	51-53	catechol-O-methyltransferase	Homo sapiens	20-24
6272977-7	1981	When the Ames mutagenesis assay was supplemented with COMT/SAM, a 36% reduction was observed in the number of revertant colonies induced by the microsomal oxidation of BP.	Benzo(a)pyrene	168-170	catechol-O-methyltransferase	Homo sapiens	54-58
7309711-9	1981	Benzo(a)pyrene hydroxylation activity was also reconstituted from the same cytochrome P-450 preparation, NADPH-cytochrome c reductase, and phosphatidylserine.	Benzo(a)pyrene	0-14	cytochrome P-450	Oryctolagus cuniculus	75-91
7309711-11	1981	The possibility that different cytochrome P-450 species are involved in fatty acid and benzo(a)pyrene hydroxylations is discussed.	Benzo(a)pyrene	87-101	cytochrome P-450	Oryctolagus cuniculus	31-47
6168690-2	1981	Lymph node cells from SJL/J mice primed in vivo with myelin basic protein (BP) were incubated in vitro with BP.	Benzo(a)pyrene	75-77	myelin basic protein	Mus musculus	53-73
6168690-4	1981	The in vitro proliferative response to BP was dependent on the presence of Lyt 1+ 2- T lymphocytes.	Benzo(a)pyrene	39-41	CD5 antigen	Mus musculus	75-80
7198004-1	1981	The effect of chronic ethanol consumption by rats on hepatic microsomal metabolism of the procarcinogen benzo[a]pyrene (B[a]P) was investigated both with respect to induction of microsomal arylhydrocarbon hydroxylase (AHH) activity and activation of B[a]P to a mutagen.	Benzo(a)pyrene	104-118	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	189-216
6114828-3	1981	Following topical application of benzo[a]pyrene (BP) or the polychlorinated biphenyl mixture Aroclor 1254 there was induction of AHH in each tissue studied.	Benzo(a)pyrene	33-47	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	129-132
6114828-3	1981	Following topical application of benzo[a]pyrene (BP) or the polychlorinated biphenyl mixture Aroclor 1254 there was induction of AHH in each tissue studied.	Benzo(a)pyrene	49-51	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	129-132
6166627-4	1981	In contrast, immunofluorescence staining of the cloned benzo[a]pyrene-transformed rabbit bladder epithelial cell line, RBC-1, revealed a reduction in filamentous keratin concomitant with the expression of vimentin filaments.	Benzo(a)pyrene	55-69	vimentin	Oryctolagus cuniculus	205-213
6167737-4	1981	Significant AFP elevation (p less than or equal to 0.01) was observed in the highest BaP treatment group after 5 wk of treatment.	Benzo(a)pyrene	85-88	alpha-fetoprotein	Rattus norvegicus	12-15
6267322-1	1981	An isolated perfused lung [IPL) preparation was used to investigate the effects of SO2 (1-2 ppm) on the metabolism of benzo[a]pyrene (BaP), a ubiquitous potent carcinogen that has been associated with the increased incidence of a human bronchiogenic carcinoma in occupational and urban populations.	Benzo(a)pyrene	118-132	prohibitin 2	Homo sapiens	134-137
7336952-1	1981	The specificity of electrophoretically homogeneous preparations of rabbit liver microsomal cytochrome P-450LM2-4 towards oxygenation of n-hexane, 7-ethoxyresorufin and benzo(a)pyrene was examined using a reconstituted system consisting of cytochrome P-450, NADPH-cytochrome P-450 reductase and dilauroylphosphatidylcholine.	Benzo(a)pyrene	168-182	cytochrome P450 2B4	Oryctolagus cuniculus	91-110
6792366-5	1981	In the presence of NADPH-cytochrome c reductase, lipid and NADPH, the pulmonary cytochrome P-448 was active in hydroxylation of benzo-[a]pyrene, but catalyzed N-demethylation of benzphetamine in a slow rate.	Benzo(a)pyrene	128-143	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-96
6450647-0	1981	Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases.	Benzo(a)pyrene	20-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-76
6793028-6	1981	Changes in the in vitro formation of benzo(a)pyrene metabolites were found to correlate with changes in the multiple forms of cytochrome P-450.	Benzo(a)pyrene	37-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	126-142
6173396-2	1981	Data in this report link the production of anti-BP antibody to the murine H-2 histocompatibility background.	Benzo(a)pyrene	48-50	histocompatibility-2, MHC	Mus musculus	74-77
17776634-13	1981	Benzo[a]pyrene was the positive control for mutagenicity requiring induced S-9.	Benzo(a)pyrene	0-14	l(3)87Ei	Drosophila melanogaster	75-78
7460073-0	1981	Quantitative analysis of cytotoxicity and mutagenicity of benzo[a]pyrene in mammalian cells (CHO/HGPRT system).	Benzo(a)pyrene	58-72	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	97-102
6161675-3	1981	Analysis of the purified myelin by SDS-polyacrylamide gel electrophoresis revealed that P1 and Pr, which are common to BP in CNS, and PM protein were missing, while P0 and P2 proteins were of the same level as the control.	Benzo(a)pyrene	119-121	zinc finger protein 185	Mus musculus	88-97
7015795-9	1981	A weak correlation, (p less than 0.05) was seen between pretreatment plasma renin activity and initial captopril-induced BP reduction.	Benzo(a)pyrene	121-123	renin	Homo sapiens	76-81
7273285-5	1981	The addition of the carcinogens diethylnitrosamine, benzo[a]pyrene, methylmethanesulphonate and ethylmethanesulphonate caused significant increases in ornithine decarboxylase activity.	Benzo(a)pyrene	52-66	ornithine decarboxylase 1	Rattus norvegicus	151-174
7333581-1	1981	Polycyclic aromatic hydrocarbon-inducible monooxygenase directed toward the substrate benzo(a)pyrene, i.e., "aryl hydrocarbon hydroxylase", was monitored in cell hybrids formed from mouse RAG cells and several human fibroblasts lines.	Benzo(a)pyrene	86-100	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-137
7438292-12	1980	As with basal AHH, the Km-value for BP was less in log phase (0.2-0.4 microM BP) than in confluent cells (0.64-1.05 microM BP).	Benzo(a)pyrene	36-38	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	14-17
7438292-12	1980	As with basal AHH, the Km-value for BP was less in log phase (0.2-0.4 microM BP) than in confluent cells (0.64-1.05 microM BP).	Benzo(a)pyrene	77-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	14-17
7438292-12	1980	As with basal AHH, the Km-value for BP was less in log phase (0.2-0.4 microM BP) than in confluent cells (0.64-1.05 microM BP).	Benzo(a)pyrene	77-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	14-17
7428120-1	1980	The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy.	Benzo(a)pyrene	33-47	glutathione S-transferase alpha 2	Rattus norvegicus	102-110
7428120-1	1980	The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy.	Benzo(a)pyrene	33-47	fatty acid binding protein 1	Rattus norvegicus	143-152
7428120-1	1980	The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy.	Benzo(a)pyrene	33-47	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	154-180
7428120-1	1980	The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy.	Benzo(a)pyrene	49-51	glutathione S-transferase alpha 2	Rattus norvegicus	102-110
7428120-1	1980	The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy.	Benzo(a)pyrene	49-51	fatty acid binding protein 1	Rattus norvegicus	143-152
7428120-1	1980	The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy.	Benzo(a)pyrene	49-51	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	154-180
7428120-4	1980	9,10-Dihydro-9,10-dihydroxybenzo[a]pyrene (BP-9,10-dihydrodiol) binds to ligandin with an affinity similar to those of the other BP metabolites studied here, but binds much less strongly to both protein A and lecithin (v/c = 10(4) and 3 x 10(4) x mol-1, respectively).	Benzo(a)pyrene	43-45	glutathione S-transferase alpha 2	Rattus norvegicus	73-81
7428120-5	1980	The low affinity of BP-9,10-dihydrodiol for lecithin would account for earlier findings that on incubation of BP with isolated rat hepatocytes, this metabolite egressed from the cells to the extracellular medium much more readily than either BP-4,5-dihydrodiol or BP-7,8-dihydrodiol.	Benzo(a)pyrene	20-22	Blood pressure QTL 4	Rattus norvegicus	242-246
7428120-5	1980	The low affinity of BP-9,10-dihydrodiol for lecithin would account for earlier findings that on incubation of BP with isolated rat hepatocytes, this metabolite egressed from the cells to the extracellular medium much more readily than either BP-4,5-dihydrodiol or BP-7,8-dihydrodiol.	Benzo(a)pyrene	20-22	Blood pressure QTL 7	Rattus norvegicus	264-268
7428120-6	1980	Calculations based on these results suggest that within hepatocytes BP and its metabolites, including BP-9,10-dihydrodiol, will be found almost exclusively associated (&gt; 98%) with lipid membranes.	Benzo(a)pyrene	68-70	Blood pressure QTL 9	Rattus norvegicus	102-106
6270846-3	1980	Similar absorption characteristics of cytochrome P-450 and turnover rates for BP on the basis o f cytochrome P-450 was observed among the different microsomal preparations.	Benzo(a)pyrene	78-80	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	98-114
7442661-10	1980	Studies on the metabolism of benzo(a)pyrene revealed that the enzyme aryl hydrocarbon hydroxylase (AHH) is present in cultured hair follicle cells.	Benzo(a)pyrene	29-43	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	69-97
7442661-10	1980	Studies on the metabolism of benzo(a)pyrene revealed that the enzyme aryl hydrocarbon hydroxylase (AHH) is present in cultured hair follicle cells.	Benzo(a)pyrene	29-43	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	99-102
7428109-2	1980	BP metabolite formation was monitored by high pressure liquid chromatography (HPLC) and by following aryl hydrocarbon hydroxylase (AHH) activity.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	101-129
7428109-2	1980	BP metabolite formation was monitored by high pressure liquid chromatography (HPLC) and by following aryl hydrocarbon hydroxylase (AHH) activity.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	131-134
7428109-6	1980	The induction of AHH by MC in these strains correlated well with the radioactive metabolites of [3H] BP remaining in the alkali extract derived from the AHH assay mixture and with the increased binding of [3H] BP to microsomal protein and DNA.	Benzo(a)pyrene	101-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	17-20
7428109-6	1980	The induction of AHH by MC in these strains correlated well with the radioactive metabolites of [3H] BP remaining in the alkali extract derived from the AHH assay mixture and with the increased binding of [3H] BP to microsomal protein and DNA.	Benzo(a)pyrene	101-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	153-156
7428109-6	1980	The induction of AHH by MC in these strains correlated well with the radioactive metabolites of [3H] BP remaining in the alkali extract derived from the AHH assay mixture and with the increased binding of [3H] BP to microsomal protein and DNA.	Benzo(a)pyrene	210-212	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	17-20
6256996-0	1980	[Studies on the activity of the aryl hydrocarbon hydroxylase and metabolism of benzo(a)pyrene in cell strains and cell lines used for testing cytotoxic and transforming ability of foreign compounds (author"s transl)].	Benzo(a)pyrene	79-93	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	32-60
6256996-1	1980	The activity of the AHH and the formation of polar metabolites from BaP was examined in several cell strains and lines, which are used for testing cytotoxic and transforming activity of environmental agents, the highest activity of the AHH and the highest capacity to metabolize BaP was found in hamster kidney cells.	Benzo(a)pyrene	68-71	aryl hydrocarbon receptor repressor	Homo sapiens	20-23
6256996-1	1980	The activity of the AHH and the formation of polar metabolites from BaP was examined in several cell strains and lines, which are used for testing cytotoxic and transforming activity of environmental agents, the highest activity of the AHH and the highest capacity to metabolize BaP was found in hamster kidney cells.	Benzo(a)pyrene	68-71	aryl hydrocarbon receptor repressor	Homo sapiens	236-239
6256996-1	1980	The activity of the AHH and the formation of polar metabolites from BaP was examined in several cell strains and lines, which are used for testing cytotoxic and transforming activity of environmental agents, the highest activity of the AHH and the highest capacity to metabolize BaP was found in hamster kidney cells.	Benzo(a)pyrene	279-282	aryl hydrocarbon receptor repressor	Homo sapiens	20-23
6256996-5	1980	In cells derived from a human bronchial carcinoma (E-14), a very low BaP metabolism was detectable which increased 3-fold after exposure (o BA.	Benzo(a)pyrene	69-72	nuclear protein, coactivator of histone transcription	Homo sapiens	51-55
7417266-0	1980	Benzo(a)pyrene metabolism by purified forms of rabbit liver microsomal cytochrome P-450, cytochrome b5 and epoxide hydrase in reconstituted phospholipid vesicles.	Benzo(a)pyrene	0-14	cytochrome P-450	Oryctolagus cuniculus	71-102
6105054-0	1980	Correlations between cytochrome P-450 and oxidative metabolism of benzo[a]pyrene and 7-ethoxycoumarin in human liver in vitro and antipyrine elimination in vivo.	Benzo(a)pyrene	66-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-37
7190824-0	1980	Hydroxylation of benzo[a]pyrene and binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to deoxyribonucleic acid catalyzed by purified forms of rabbit liver microsomal cytochrome P-450.	Benzo(a)pyrene	17-31	cytochrome P-450	Oryctolagus cuniculus	188-204
7357559-0	1980	High-pressure liquid chromatographic analysis of benzo(a)pyrene metabolism by human lymphocytes from donors of different aryl hydrocarbon hydroxylase inducibility and antipyrine half-lives.	Benzo(a)pyrene	49-63	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	121-149
6930944-3	1980	Phenobarbital is also able to potentiate the inducing action of low doses of benzo(a)pyrene on the lung AHH activity.	Benzo(a)pyrene	77-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	104-107
6154440-6	1980	In acute early MS lesions the decrease in MAG immunostaining extended far beyond the margin of acute demyelination, where the BP staining of degenerating sheaths often was increased.	Benzo(a)pyrene	126-128	myelin associated glycoprotein	Homo sapiens	42-45
7226144-2	1980	We now report epoxide hydratase and glutathione S-transferase, enzymes important in the further metabolism of certain benzo[a]pyrene metabolites formed by the monooxygenase system, have been detected in human lung tissues from patients undergoing surgery for lung cancer.	Benzo(a)pyrene	118-132	epoxide hydrolase 2	Homo sapiens	14-31
7417608-0	1980	Effects of perinatal exposure to benzo(a)pyrene on the aryl hydrocarbon hydroxylase system of adult rat liver.	Benzo(a)pyrene	33-47	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	55-83
7226144-2	1980	We now report epoxide hydratase and glutathione S-transferase, enzymes important in the further metabolism of certain benzo[a]pyrene metabolites formed by the monooxygenase system, have been detected in human lung tissues from patients undergoing surgery for lung cancer.	Benzo(a)pyrene	118-132	glutathione S-transferase kappa 1	Homo sapiens	36-61
549739-10	1979	The AHH activity drastically modifies the overall rate of the BP metabolism but does not affect the qualitative pattern of the excreted metabolites.	Benzo(a)pyrene	62-64	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	4-7
6160257-1	1980	Bovine basic protein (BP) was digested with purified bovine brain cathepsin D to produce well defined BP derived peptides 1-42, 43-88, 43-169, and 89-169.	Benzo(a)pyrene	22-24	cathepsin D	Bos taurus	66-77
509418-5	1979	The Km of AHH for benzo[a]pyrene is decreased in the presence of caffeine.	Benzo(a)pyrene	18-32	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	10-13
118380-8	1979	This lack of correlation between increased AHH activity and increased metabolism of BP to mutagen in liver is in marked contrast to correlations seen in mice.	Benzo(a)pyrene	84-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	43-46
543717-0	1979	Induction of DT-diaphorase by benzo(a)pyrene in rat liver.	Benzo(a)pyrene	30-44	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	13-26
118169-4	1979	In reconstituted systems containing the purified cytochrome and NADPH-cytochrome P-450 reductase, ethoxycoumarin deethylation and benzo(a)pyrene hydroxylation catalyzed by cytochrome P-450 and P-448 were completely inhibited by the homologous antibody, while essentially no effect was observed with heterologous conbinations of antigen and antibody.	Benzo(a)pyrene	130-144	cytochrome p450 oxidoreductase	Rattus norvegicus	64-96
118169-4	1979	In reconstituted systems containing the purified cytochrome and NADPH-cytochrome P-450 reductase, ethoxycoumarin deethylation and benzo(a)pyrene hydroxylation catalyzed by cytochrome P-450 and P-448 were completely inhibited by the homologous antibody, while essentially no effect was observed with heterologous conbinations of antigen and antibody.	Benzo(a)pyrene	130-144	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	172-198
509689-1	1979	The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells.	Benzo(a)pyrene	58-73	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-48
509413-3	1979	Of 3 compounds tested, benzo[a]pyrene (BP) stimulates the highest level of AHH activity.	Benzo(a)pyrene	23-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-78
509413-3	1979	Of 3 compounds tested, benzo[a]pyrene (BP) stimulates the highest level of AHH activity.	Benzo(a)pyrene	39-41	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-78
522515-2	1979	Isolated intestinal cells catalyzed the cytochrome P-450 dependent metabolism of benzo(a)pyrene, harmine, ethoxyresorufin and ethoxycoumarin.	Benzo(a)pyrene	81-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-56
390362-0	1979	The epoxide hydratase inducer trans-stilbene oxide shifts the metabolic epoxidation of benzo(a)pyrene from the bay- to the K-region and reduces its mutagenicity.	Benzo(a)pyrene	87-101	epoxide hydrolase 2	Homo sapiens	4-21
509689-1	1979	The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells.	Benzo(a)pyrene	58-73	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	50-53
509689-1	1979	The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells.	Benzo(a)pyrene	75-78	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-48
509689-1	1979	The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells.	Benzo(a)pyrene	75-78	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	50-53
509689-2	1979	These cells (NMuLi cl 8) have low basal levels of AHH which can be induced greater than 100-fold by BaP.	Benzo(a)pyrene	100-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	50-53
474152-4	1979	In methylcholanthrene-induced rat lung, the metabolism of BP was inhibited by alpha-naphthoflavone, an inhibitor of monooxygenase, and less with diethylmaleate, a depletor of glutathione, with salicylamide, an inhibitor of conjugases, and, astonishingly, with D-saccharo-1,4-lactone, an inhibitor of beta-glucuronidase.	Benzo(a)pyrene	58-60	glucuronidase, beta	Rattus norvegicus	300-318
429376-1	1979	Catalytic differences between two purified forms of cytochrome P-450 in the metabolism of benzo(a)pyrene.	Benzo(a)pyrene	90-104	cytochrome P-450	Oryctolagus cuniculus	52-68
497269-1	1979	It was shown that metyrapone, the inhibitor of arylhydrocarbonhydroxylase, taken at concentrations equimolar to that of cytochrome P-450 non-competitively inhibits the hydroxylation of 3,4-benzpyrene in the liver microsomes of inbred mice of the C57BL/6 and AKR strains.	Benzo(a)pyrene	185-199	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	120-136
115836-3	1979	AHH activity is measured by conversion of benzo[a]pyrene (BP) to 3-hydroxy BP in homogenized cell extracts from control and treated cultures and is reported as pmol product formed/mg protein/min.	Benzo(a)pyrene	42-56	aryl hydrocarbon receptor repressor	Homo sapiens	0-3
115836-3	1979	AHH activity is measured by conversion of benzo[a]pyrene (BP) to 3-hydroxy BP in homogenized cell extracts from control and treated cultures and is reported as pmol product formed/mg protein/min.	Benzo(a)pyrene	58-60	aryl hydrocarbon receptor repressor	Homo sapiens	0-3
313933-0	1979	Epidermal growth factor and the control of proliferation of Balb 3T3 and benzo[a]pyrene-transformed Balb 3T3 cells.	Benzo(a)pyrene	73-87	epidermal growth factor	Mus musculus	0-23
227145-0	1979	Increased aryl hydrocarbon hydroxylase and prolyl hydroxylase activities in lung organ cultures exposed to benzo[a]pyrene.	Benzo(a)pyrene	107-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	10-38
227145-1	1979	Exposure of neo-natal rat lungs in organ culture to 10--25 microM benzo[a]pyrene (BaP) elevated the activities of aryl hydrocarbon hydroxylase (AHH) and prolyl hydroxylase (PH).	Benzo(a)pyrene	66-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	114-142
227145-1	1979	Exposure of neo-natal rat lungs in organ culture to 10--25 microM benzo[a]pyrene (BaP) elevated the activities of aryl hydrocarbon hydroxylase (AHH) and prolyl hydroxylase (PH).	Benzo(a)pyrene	66-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	144-147
227145-1	1979	Exposure of neo-natal rat lungs in organ culture to 10--25 microM benzo[a]pyrene (BaP) elevated the activities of aryl hydrocarbon hydroxylase (AHH) and prolyl hydroxylase (PH).	Benzo(a)pyrene	82-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	114-142
227145-1	1979	Exposure of neo-natal rat lungs in organ culture to 10--25 microM benzo[a]pyrene (BaP) elevated the activities of aryl hydrocarbon hydroxylase (AHH) and prolyl hydroxylase (PH).	Benzo(a)pyrene	82-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	144-147
229676-1	1979	The Cu(Lys)2 complex is shown to be an effective inhibitor of the oxidation of 3,4-benzpyrene and aniline in microsomes.	Benzo(a)pyrene	79-93	aminoadipate-semialdehyde dehydrogenase	Homo sapiens	4-12
288335-1	1979	The influence of microsomal (mAHH) and nuclear (nAHH) aryl hydrocarbon hydroxylase activity on the covalent binding of tritiated benzo(a)pyrene to rat liver DNA was evaluated in vivo.	Benzo(a)pyrene	129-143	aryl-hydrocarbon receptor	Mus musculus	29-33
37873-4	1979	3 The possibility that a beta-blocking agent combined with a thiazide diuretic might produce better BP control, prevent thiazide-induced abnormalities and exert a coronary prevention action with once daily administration would suggest that such a combination should be the ideal initial therapy for most patients with hypertension.	Benzo(a)pyrene	100-102	amyloid beta precursor protein	Homo sapiens	23-29
227614-1	1979	The complex between bovine serum albumin (BSA) and benzo[a]pyrene (BaP) exhibits three different types of fluorescence.	Benzo(a)pyrene	51-65	prohibitin 2	Homo sapiens	67-70
106274-8	1979	Aryl hydrocarbon hydroxylase (AHH) was measured in all tissue using BP as substrate.	Benzo(a)pyrene	68-70	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-28
106274-8	1979	Aryl hydrocarbon hydroxylase (AHH) was measured in all tissue using BP as substrate.	Benzo(a)pyrene	68-70	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	30-33
106274-11	1979	Metabolism of BP to mutagens by liver homogenates was correlated with extent of AHH induction.	Benzo(a)pyrene	14-16	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	80-83
106390-3	1979	Hepa-1 was found to be very sensitive to benzo[a]pyrene (BaP) toxicity and a single-step selection procedure for isolating clones resistant to BaP at 4 microgram/ml was designed.	Benzo(a)pyrene	41-55	prohibitin 2	Mus musculus	57-60
719813-1	1978	In a Namru mouse liver epithelial cell strain designated NMuLi, aryl hydrocarbon hydroxylase (AHH) activity peaked at 12 h post-induction with 1 microgram/ml of benzo(a)pyrene (BaP) in both confluent and growing cells.	Benzo(a)pyrene	177-180	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	64-92
719813-1	1978	In a Namru mouse liver epithelial cell strain designated NMuLi, aryl hydrocarbon hydroxylase (AHH) activity peaked at 12 h post-induction with 1 microgram/ml of benzo(a)pyrene (BaP) in both confluent and growing cells.	Benzo(a)pyrene	177-180	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	94-97
719813-4	1978	Induced AHH levels were higher in epithelial clones that were sensitive to the toxicity of BaP than in resistant clones.	Benzo(a)pyrene	91-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	8-11
719813-5	1978	The survival fraction of clones from NMuLi and of subclones derived from a sensitive clone of NMuLi after BaP treatment was a negative exponential function of the maximal induced AHH activity in the clones.	Benzo(a)pyrene	106-109	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	179-182
719999-8	1978	Study in vitro of the kinetics of two reactions, namely aminopyrine N-demethylation and 3,4-benzpyrene hydroxylation, catalysed by the hepatic microsomal cytochrom P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450 with different catalytic properties from those of forms induced by either phenobarbital or 3-methylcholanthrene.	Benzo(a)pyrene	88-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	246-262
719999-8	1978	Study in vitro of the kinetics of two reactions, namely aminopyrine N-demethylation and 3,4-benzpyrene hydroxylation, catalysed by the hepatic microsomal cytochrom P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450 with different catalytic properties from those of forms induced by either phenobarbital or 3-methylcholanthrene.	Benzo(a)pyrene	88-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	339-355
711851-10	1978	Assay of several defined constituents of coal tar for AHH induction showed that BP was the most potent inducer of AHH tested.	Benzo(a)pyrene	80-82	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	54-57
711851-10	1978	Assay of several defined constituents of coal tar for AHH induction showed that BP was the most potent inducer of AHH tested.	Benzo(a)pyrene	80-82	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	114-117
98453-1	1978	The activity of aryl hydrocarbon hydroxylase (substrate: benzo(a)pyrene) was increased in the tracheas of rats exposed to cigarette smoke for 1 h daily for either 1 or 10 days.	Benzo(a)pyrene	57-71	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	16-44
277915-0	1978	Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.	Benzo(a)pyrene	96-110	cytochrome P-450	Oryctolagus cuniculus	58-74
277915-3	1978	P-450(LM2) is more active than P-450(LM4) in the metabolism of BzP and in its conversion to products that bind to DNA.	Benzo(a)pyrene	63-66	cytochrome P450 2B4	Oryctolagus cuniculus	0-9
277915-3	1978	P-450(LM2) is more active than P-450(LM4) in the metabolism of BzP and in its conversion to products that bind to DNA.	Benzo(a)pyrene	63-66	cytochrome P450 1A2	Oryctolagus cuniculus	31-40
277915-5	1978	The ratio of activity (percent substrate metabolized) with BzP relative to that with (-)trans-7,8-diol is 21 for P-450(LM2) and 0.3 for P-450(LM4); P-450(LM1), P-450(LM3b), and P-450(LM7) gave intermediate ratios.	Benzo(a)pyrene	59-62	cytochrome P450 2B4	Oryctolagus cuniculus	113-122
277915-5	1978	The ratio of activity (percent substrate metabolized) with BzP relative to that with (-)trans-7,8-diol is 21 for P-450(LM2) and 0.3 for P-450(LM4); P-450(LM1), P-450(LM3b), and P-450(LM7) gave intermediate ratios.	Benzo(a)pyrene	59-62	cytochrome P450 1A2	Oryctolagus cuniculus	136-145
277915-8	1978	The substrate specificity and regio- and stereo-selectivity of the different forms of cytochrome P-450 may regulate the balance between activation and detoxification pathways of BzP and therefore determine the susceptibility of individual tissues, strains, and species to the carcinogenic action of BzP.	Benzo(a)pyrene	178-181	cytochrome P-450	Oryctolagus cuniculus	86-102
277915-8	1978	The substrate specificity and regio- and stereo-selectivity of the different forms of cytochrome P-450 may regulate the balance between activation and detoxification pathways of BzP and therefore determine the susceptibility of individual tissues, strains, and species to the carcinogenic action of BzP.	Benzo(a)pyrene	299-302	cytochrome P-450	Oryctolagus cuniculus	86-102
647664-1	1978	Intratracheal instillation studies with benzo(a)pyrene in bovine serum albumin in Syrian hamsters.	Benzo(a)pyrene	40-54	albumin	Mesocricetus auratus	65-78
399458-4	1979	Finally, nuclei have been demonstrated to catalyze the formation of benzo[a]pyrene syn- and anti-diolepoxides, ultimate carcinogenic forms of this polycyclic hydrocarbon.	Benzo(a)pyrene	68-82	synemin	Homo sapiens	83-86
647664-2	1978	The chronic effect of benzo(a)pyrene (B(a)P) administered intratracheally in bovine serum albumin was studied in Syrian golden hamsters.	Benzo(a)pyrene	22-36	albumin	Mesocricetus auratus	84-97
619459-3	1978	These results suggest that conjugates of benzo(a)pyrene may be converted by beta-glucuronidase at intracellular and organ sites distal to the initial sites of oxygenation and conjugation of benzo(a)pyrene to activated intermediates that are possibly carcinogenic.	Benzo(a)pyrene	41-55	glucuronidase beta	Homo sapiens	76-94
619459-3	1978	These results suggest that conjugates of benzo(a)pyrene may be converted by beta-glucuronidase at intracellular and organ sites distal to the initial sites of oxygenation and conjugation of benzo(a)pyrene to activated intermediates that are possibly carcinogenic.	Benzo(a)pyrene	190-204	glucuronidase beta	Homo sapiens	76-94
80941-2	1978	In the guinea pig, experimental allergic encephalomyelitis (EAE) is induced by one injection of myelin basic protein in complete Freund"s adjuvant (BP/CFA).	Benzo(a)pyrene	148-150	myelin basic protein	Cavia porcellus	96-116
106613-2	1978	The studies included the demethylation of ethylmorphine, dimethylnitrosamine, and 4-dimethylaminoazobenzene as well as the investigation of the activity of aryl hydrocarbon hydroxylase and of azoreductase using benzo(a)pyrene and 4-dimethylaminoazobenzene as substrates, respectively.	Benzo(a)pyrene	211-225	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	156-184
80946-10	1978	These results suggested that the Plg activator secreted by the macrophages generated plasmin, which selectively degraded BP.	Benzo(a)pyrene	121-123	plasminogen	Mus musculus	33-36
80946-11	1978	This interpretation was confirmed by the observation that urokinase, a Plg activator, plus Plg was effective in degrading BP in myelin.	Benzo(a)pyrene	122-124	plasminogen	Mus musculus	71-74
80946-11	1978	This interpretation was confirmed by the observation that urokinase, a Plg activator, plus Plg was effective in degrading BP in myelin.	Benzo(a)pyrene	122-124	plasminogen	Mus musculus	91-94
80946-12	1978	We propose that the action of neutral proteinases released by stimulated macrophages, and its amplification by the Plg-plasmin system, may play a significant role in several inflammatory demyelinating diseases; and that the relative specificity of these reactions for myelin lies in the extreme susceptibility of BP to proteolysis.	Benzo(a)pyrene	313-315	plasminogen	Mus musculus	115-118
697921-0	1978	Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity.	Benzo(a)pyrene	142-156	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-65
630646-1	1978	The alkylating properties of pairs of syn- and anti-isomers of 2 diol-epoxides derived from benzo(a)pyrene (BP) and of 1 derived from benz(a)anthracene (BA) have been investigated.	Benzo(a)pyrene	92-106	synemin	Homo sapiens	38-41
737248-0	1978	The development of DT-diaphorase in rat liver and its induction by benzo(a)pyrene.	Benzo(a)pyrene	67-81	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	19-32
737248-1	1978	The development of cytosolic DT-diaphorase--NAD(P)H dehydrogenase, quinone, EC 1.6.99.2--and its induction by benzo(a)pyrene has been studied in rat liver.	Benzo(a)pyrene	110-124	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	29-42
630646-1	1978	The alkylating properties of pairs of syn- and anti-isomers of 2 diol-epoxides derived from benzo(a)pyrene (BP) and of 1 derived from benz(a)anthracene (BA) have been investigated.	Benzo(a)pyrene	108-110	synemin	Homo sapiens	38-41
413503-0	1977	The effects of phenobarbital and 3,4-benzypyrene on microsomal cytochrome P-450 and NADPH-cytochrome C reductase in regenerating rat liver after partial hepatectomy or chemical injury.	Benzo(a)pyrene	33-48	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	63-79
341851-0	1977	Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene.	Benzo(a)pyrene	70-84	epoxide hydrolase 2	Homo sapiens	13-30
341853-3	1977	It was shown with such a lipophilic compound, benzo(a)pyrene, as a model substance and with liver enzyme mediated bacterial mutagenesis as biological endpoint that species and strain differences in epoxide hydratase and monooxygenases are reflected in very dramatic differences in mutagenicity of benzo(a)pyrene which varied from extremely potent to a degree which could easily be overlooked.	Benzo(a)pyrene	46-60	epoxide hydrolase 2	Homo sapiens	198-215
341853-3	1977	It was shown with such a lipophilic compound, benzo(a)pyrene, as a model substance and with liver enzyme mediated bacterial mutagenesis as biological endpoint that species and strain differences in epoxide hydratase and monooxygenases are reflected in very dramatic differences in mutagenicity of benzo(a)pyrene which varied from extremely potent to a degree which could easily be overlooked.	Benzo(a)pyrene	297-311	epoxide hydrolase 2	Homo sapiens	198-215
912816-5	1977	The binding levels of BP to DNA and protein in the explant was lowered by co-incubation with 7,8-benzoflavone (7,8-BF) (3.6 and 18.0 micron), a known inhibitor of AHH, and with disulfiram (100 micron), an anti-oxidant.	Benzo(a)pyrene	22-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	163-166
884659-0	1977	Induction of aryl hydrocarbon hydroxylase and forestomach tumors ben benzo(a)pyrene.	Benzo(a)pyrene	69-83	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	13-41
890843-2	1977	Mouse epidermal homogenates contain an inducible aryl hydrocarbon hydroxylase (AHH) complex that catalyzes the formation of benzo(a)pyrene-7,8-dihydrodiol from benzo(a)pyrene (BP) as assessed by high pressure liquid chromatography (HPLC).	Benzo(a)pyrene	124-138	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-77
884659-2	1977	Among all tissues examined, the forestomach showed the greatest increase of aryl hydrocarbon hydroxylase (AHH) activity following acute or chronic administration of BP.	Benzo(a)pyrene	165-167	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	76-104
884659-2	1977	Among all tissues examined, the forestomach showed the greatest increase of aryl hydrocarbon hydroxylase (AHH) activity following acute or chronic administration of BP.	Benzo(a)pyrene	165-167	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	106-109
884659-3	1977	Single acute doses of BP induced AHH activity in forestomach, glandular stomach, lung, and small intestine, but not in the kidney and liver of these animals.	Benzo(a)pyrene	22-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-36
884659-4	1977	Similarly, after chronic administration of BP, AHH activity was inducible in the forestomach, glandular stomach, and lung, but again not in the liver.	Benzo(a)pyrene	43-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	47-50
884659-5	1977	Although the formation of tumors is associated with greater inducibility of AHH activity in the forestomach after BP administration, the relationship between tissue inducibility of AHH activity and susceptibility to BP carcinogenesis is still not clear.	Benzo(a)pyrene	114-116	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	76-79
884659-6	1977	Further studies regarding the formation of specific carcinogenic epoxides of BP in itssues both susceptible (e.g., forestomach) and resistant to BP carcinogenesis would more clearly define the relationship between AHH inducibility and BP carcinogenesis.	Benzo(a)pyrene	77-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	214-217
890843-2	1977	Mouse epidermal homogenates contain an inducible aryl hydrocarbon hydroxylase (AHH) complex that catalyzes the formation of benzo(a)pyrene-7,8-dihydrodiol from benzo(a)pyrene (BP) as assessed by high pressure liquid chromatography (HPLC).	Benzo(a)pyrene	176-178	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-77
856463-2	1977	Aryl hydrocarbon hydroxylase, the levels of activity of which varied with the different nuclear systems, was highly specific in the activation of the benzo(a)pyrene to forms that bind to DNA.	Benzo(a)pyrene	150-164	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-28
844914-3	1977	Aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity and metabolism of benzo(a)pyrene to water-soluble products were measured in cultures of body fibroblasts and kidney epithelial cells from different human embryos.	Benzo(a)pyrene	18-32	aryl hydrocarbon receptor repressor	Homo sapiens	47-50
856576-1	1977	Inhibition by CO of benzo[a]pyrene hydroxylation was studied in hepatic microsomes from rats pretreated with phenobarbital, 3-methylcholanthrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin, from animals treated with vehicle (saline or corn oil, respectively), and in a reconstituted microsomal cytochrome P-448 system prepared from rats treated with 3-methylcholanthrene.	Benzo(a)pyrene	20-34	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	300-305
839417-1	1977	Fluorometric studies on the binding of benz[a]anthracene and benzo[a]pyrene to human serum albumin are described.	Benzo(a)pyrene	61-75	albumin	Homo sapiens	85-98
68911-14	1977	The activity of a mixture of dibenzo[a,h]anthracene and benzo[a]pyrene depends to about 40% on dibenzo[a,h]anthracene; and that of 12 PAH to 30% on dibenzo[a,h]anthracene alone or to 80% on a mixture of dibenzo[a,h]anthracene and benzo[a]pyrene.	Benzo(a)pyrene	230-244	phenylalanine hydroxylase	Mus musculus	134-137
10077-8	1976	It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.	Benzo(a)pyrene	137-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	232-260
10077-8	1976	It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.	Benzo(a)pyrene	137-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	342-370
10077-8	1976	It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.	Benzo(a)pyrene	218-220	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	232-260
10077-8	1976	It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.	Benzo(a)pyrene	218-220	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	232-260
975055-11	1976	Levels of AHH, the enzyme that metabolizes BaP to its cytotoxic derivatives, were only 2.4 times higher in exponentially growing than in confluent cells, suggesting that cell division was responsible for the large differential toxicity.	Benzo(a)pyrene	43-46	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	10-13
975055-13	1976	The results indicate that the metabolism of BaP by AHH to produce cytotoxic metabolites, which may cause lesions that are expressed upon cell division, is responsible for the cytotoxicity of BaP to NMuLi.	Benzo(a)pyrene	44-47	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-54
975055-13	1976	The results indicate that the metabolism of BaP by AHH to produce cytotoxic metabolites, which may cause lesions that are expressed upon cell division, is responsible for the cytotoxicity of BaP to NMuLi.	Benzo(a)pyrene	191-194	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-54
124107-0	1975	[The influence of 3,4-benzpyrene on the DNA concentration and ATP-ase activity of differentiating myogenic cells].	Benzo(a)pyrene	18-32	dynein axonemal heavy chain 8	Homo sapiens	62-69
971337-0	1976	Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes.	Benzo(a)pyrene	65-79	epoxide hydrolase 2	Homo sapiens	39-56
182361-9	1976	The binding of [3H]BP to lung nuclei was greatly enhanced by liver microsomes but only slightly by lung microsomes, which had rather low AHH activity.	Benzo(a)pyrene	19-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	137-140
821945-4	1976	Highly purified cytochrome P-450 from phenobarbital-treated rats is relatively poor in catalyzing the formation of mutagenic metabolites from benzo (a)pyrene.	Benzo(a)pyrene	142-157	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	16-32
821945-9	1976	The number of mutations induced per nmol of hemoprotein is approximately 3- to 4-fold higher when trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene replaces benzo (a)pyrene as a substrate for the cytochrome P-448-dependent monooxygenase system.	Benzo(a)pyrene	129-144	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	193-209
1066669-1	1976	Benzo(a)pyrene is metabolically and stereospecifically converted by mixed-function oxidases of rat liver microsomes and epoxide hydratase (glycol hydro-lyase (epoxide-forming), EC 4.2.1.63)to the single enantiomer (-)r-7,t-8-dihydroxy-7,8-dihydrobenzol (A) pyrene.	Benzo(a)pyrene	0-14	epoxide hydrolase 2	Rattus norvegicus	120-137
181338-1	1976	Aryl hydrocarbon (benzo(a)pyrene) hydroxylase induced by dibutyryl cyclic AMP (dcAMP), plus aminophylline (AHH I) can be ditsinguished from the hydroxylase induced by benz (a) anthracene (AHH II) by its lower Km for benzo (a) pyrene.	Benzo(a)pyrene	216-232	aryl hydrocarbon receptor repressor	Homo sapiens	107-110
973974-2	1976	2 On the high sodium intake when angiotensin II and plasma renin activity (PRA) were suppressed, P113 infusion (5-10 mug kg-1 min-1) caused a slight rise in BP and a marked drop in urine flow and sodium excretion, with a fall in glomerular filtration rate, and effective renal plasma flow.	Benzo(a)pyrene	157-159	signal transducer and activator of transcription 2	Homo sapiens	97-101
944582-0	1976	Effect of benzo(a)pyrene and chlorpromazine on aryl hydrocarbon hydroxylase activity from rat tissues.	Benzo(a)pyrene	10-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	47-75
815258-9	1976	When added to the reconstituted system, the cytochrome P-448 antibody inhibits purified rat cytochrome P-448- and P-450-supported N-demethylation of benzphetamine, O-deethylation of ethoxycoumarin, hydroxylation of benzo[a]pyrene, and the hydroxylation of testosterone at the 6beta, 7alpha, and 16alpha positions.	Benzo(a)pyrene	215-229	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	44-60
813227-10	1976	When CO was bubbled through the reaction mixture with or without added NADPH, binding of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene was partially inhibited, indicating that cytochrome P-450 plays a role in this activation.	Benzo(a)pyrene	89-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	180-196
1244357-3	1976	All inducers of rat hepatic epoxide hydratase (determined with [7-3H]styrene oxide as substrate) which have been discovered also induced monooxygenase (determined with benzo(a)pyrene as substrate) suggesting a possible common biosynthetic control of these enzymes.	Benzo(a)pyrene	168-182	epoxide hydrolase 2	Rattus norvegicus	28-45
1026852-4	1976	Injection of benzo(a)pyrene at two dose levels caused a much greater increase in both liver and lung aryl hydrocarbon hydroxylase than smoking.	Benzo(a)pyrene	13-27	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	101-129
1102464-6	1975	When the mutagen, precursor, benzo(a)pyrene, was incubated together with TA 1537 and a mammalian microsomal preparation in the presence of a system generating the co-factor necessary for mono-oxygenase activity, activation to mutagenic species was observed which was dramatically increased in the presence of a potent epoxide hydratase inhibitor, 1,1,1-trichloropropene 2,3-oxide, suggesting epoxide(s) as the (or one of the) mutagenically active species metabolically produced in situ.	Benzo(a)pyrene	29-43	epoxide hydrolase 2	Homo sapiens	318-335
1060073-0	1975	Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver.	Benzo(a)pyrene	33-47	cytochrome P-450	Oryctolagus cuniculus	79-95
1060073-1	1975	High-pressure liquid chromatography was used to detect oxygenated products of benzo[a]pyrene formed in a reconstituted microsomal mixed-function oxidase system containing cytochrome P-450 (P-450LM), phospholipid, and NADPH-cytochrome P-450 reductase (NADPH: ferricytochrome oxidoreductase, EC 1.6.2.4).	Benzo(a)pyrene	78-92	cytochrome P-450	Oryctolagus cuniculus	171-187
1060073-1	1975	High-pressure liquid chromatography was used to detect oxygenated products of benzo[a]pyrene formed in a reconstituted microsomal mixed-function oxidase system containing cytochrome P-450 (P-450LM), phospholipid, and NADPH-cytochrome P-450 reductase (NADPH: ferricytochrome oxidoreductase, EC 1.6.2.4).	Benzo(a)pyrene	78-92	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	217-249
1170030-1	1975	The interactions of benzo(a)pyrene (B(a)P) with the cell surface membrane were studied by measuring B(a)P uptake into intact mammalian cells and by determining B(a)P fluorescence in the presence of isolated cell surface membranes.	Benzo(a)pyrene	20-34	prohibitin 2	Homo sapiens	36-41
4139202-0	1974	The antibody response to myelin basic protein (BP) in Lewis rats: the effect of time, dosage of BP, and dosage of Mycobacterium butyricum.	Benzo(a)pyrene	47-49	myelin basic protein	Rattus norvegicus	25-45
4472415-0	1974	Trapping of benzo(a)pyrene by bovine serum albumin.	Benzo(a)pyrene	12-26	albumin	Homo sapiens	37-50
4366168-2	1974	The involvement of cytochrome b5 in the NADH-dependent hydroxylation of 3,4-benzpyrene by a reconstituted cytochrome P-448-containing system.	Benzo(a)pyrene	72-86	cytochrome b5 type A	Homo sapiens	19-32
5592033-0	1967	[Interaction of pyrene and 3,4-benzpyrene with human serum albumin].	Benzo(a)pyrene	27-41	albumin	Homo sapiens	59-66
4650614-1	1972	V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation.	Benzo(a)pyrene	68-82	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	35-64
33544859-7	2021	Although the gpt mutant frequency (MF) was significantly increased by BaP in both mouse genotypes, it was three times higher in Rev3l L2610M gpt delta than gpt delta mice after treatment with 160 mg/kg BaP.	Benzo(a)pyrene	70-73	glutamic pyruvic transaminase, soluble	Mus musculus	13-16
14396963-0	1955	[Behavior of pancreatic lipase in the presence of 3,4-benzopyrene.	Benzo(a)pyrene	50-65	pancreatic lipase	Homo sapiens	13-30
33647641-8	2021	Once this loop is activated by BaP or BPDE exposure, both pathways in this loop would be up-regulated, promote EIF4E transcription, inhibit trophoblast cell proliferation, and further induce miscarriage.	Benzo(a)pyrene	31-34	eukaryotic translation initiation factor 4E	Homo sapiens	111-116
33544859-7	2021	Although the gpt mutant frequency (MF) was significantly increased by BaP in both mouse genotypes, it was three times higher in Rev3l L2610M gpt delta than gpt delta mice after treatment with 160 mg/kg BaP.	Benzo(a)pyrene	202-205	glutamic pyruvic transaminase, soluble	Mus musculus	13-16
33544859-7	2021	Although the gpt mutant frequency (MF) was significantly increased by BaP in both mouse genotypes, it was three times higher in Rev3l L2610M gpt delta than gpt delta mice after treatment with 160 mg/kg BaP.	Benzo(a)pyrene	202-205	REV3 like, DNA directed polymerase zeta catalytic subunit	Mus musculus	128-133
34027802-7	2021	Our results clarified that B[a] P exposure caused a subsequent decrease in the activities of antioxidant enzymes (SOD, CAT), and conversely (MDA) levels elevated markedly.	Benzo(a)pyrene	27-33	superoxide dismutase 1	Homo sapiens	114-117
34050522-0	2021	Environmental Pollutant Benzo[a]pyrene Upregulated Long Non-coding RNA HZ07 Inhibits Trophoblast Cell Migration by Inactivating PI3K/AKT/MMP2 Signaling Pathway in Recurrent Pregnancy Loss.	Benzo(a)pyrene	24-38	AKT serine/threonine kinase 1	Homo sapiens	133-136
34050522-0	2021	Environmental Pollutant Benzo[a]pyrene Upregulated Long Non-coding RNA HZ07 Inhibits Trophoblast Cell Migration by Inactivating PI3K/AKT/MMP2 Signaling Pathway in Recurrent Pregnancy Loss.	Benzo(a)pyrene	24-38	matrix metallopeptidase 2	Homo sapiens	137-141
34050522-6	2021	These results demonstrated a novel regulatory pathway in which BaP downregulated AKT phosphorylation and inhibited MMP2 expression by upregulating lnc-HZ07, suggesting that lnc-HZ07 could be considered as a potential pathological marker of BaP-induced RPL and therapeutic target for this disease.	Benzo(a)pyrene	63-66	AKT serine/threonine kinase 1	Homo sapiens	81-84
34050522-6	2021	These results demonstrated a novel regulatory pathway in which BaP downregulated AKT phosphorylation and inhibited MMP2 expression by upregulating lnc-HZ07, suggesting that lnc-HZ07 could be considered as a potential pathological marker of BaP-induced RPL and therapeutic target for this disease.	Benzo(a)pyrene	63-66	matrix metallopeptidase 2	Homo sapiens	115-119
34050522-6	2021	These results demonstrated a novel regulatory pathway in which BaP downregulated AKT phosphorylation and inhibited MMP2 expression by upregulating lnc-HZ07, suggesting that lnc-HZ07 could be considered as a potential pathological marker of BaP-induced RPL and therapeutic target for this disease.	Benzo(a)pyrene	240-243	AKT serine/threonine kinase 1	Homo sapiens	81-84
34050522-6	2021	These results demonstrated a novel regulatory pathway in which BaP downregulated AKT phosphorylation and inhibited MMP2 expression by upregulating lnc-HZ07, suggesting that lnc-HZ07 could be considered as a potential pathological marker of BaP-induced RPL and therapeutic target for this disease.	Benzo(a)pyrene	240-243	matrix metallopeptidase 2	Homo sapiens	115-119
34028472-4	2021	The GNP-ICS assay based on a GNP-labeled mAb showed broad specificity in the detection of B[a]P and its analogues, with cut-off and visual LOD values of 100 and 10 ng mL-1, respectively.	Benzo(a)pyrene	90-95	L1 cell adhesion molecule	Mus musculus	167-171
34027802-7	2021	Our results clarified that B[a] P exposure caused a subsequent decrease in the activities of antioxidant enzymes (SOD, CAT), and conversely (MDA) levels elevated markedly.	Benzo(a)pyrene	27-33	catalase	Homo sapiens	119-122
34027802-8	2021	Also, B[a] P induced DNA damages and activated the apoptotic pathway, presented by upregulated Bax, caspase-3, and downregulated Bcl-2 gens.	Benzo(a)pyrene	6-12	BCL2 associated X, apoptosis regulator	Homo sapiens	95-98
34027802-8	2021	Also, B[a] P induced DNA damages and activated the apoptotic pathway, presented by upregulated Bax, caspase-3, and downregulated Bcl-2 gens.	Benzo(a)pyrene	6-12	caspase 3	Homo sapiens	100-109
34027802-8	2021	Also, B[a] P induced DNA damages and activated the apoptotic pathway, presented by upregulated Bax, caspase-3, and downregulated Bcl-2 gens.	Benzo(a)pyrene	6-12	BCL2 apoptosis regulator	Homo sapiens	129-134
33978294-9	2021	Also, BaP increased caspase-3 immunoreactivity.	Benzo(a)pyrene	6-9	caspase 3	Rattus norvegicus	20-29
33991922-4	2021	In this study, complexes of BaP with CYP1A1, CYP1B1 or CYP2C19 compound I were successfully simulated by QM/MM methods and verified by metabolic clearance, and the mutagenicity of chemicals was then predicted by the BaP-7,8-epoxide-related metabolic conformation fitness (MCF) approach, which was validated by Ames tests, showing satisfying accuracy (R2 = 0.46-0.66).	Benzo(a)pyrene	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	37-43
33956355-7	2021	In spheroids, BaP exposure resulted in a concentration-dependent increase in Cyp1a4 mRNA expression at 8h followed by upregulation of DDR genes at 24h, whereas Cyp1a4 mRNA induction was only observed at 48h in monolayer cells.	Benzo(a)pyrene	14-17	cytochrome P450 1A4	Gallus gallus	77-83
33956355-7	2021	In spheroids, BaP exposure resulted in a concentration-dependent increase in Cyp1a4 mRNA expression at 8h followed by upregulation of DDR genes at 24h, whereas Cyp1a4 mRNA induction was only observed at 48h in monolayer cells.	Benzo(a)pyrene	14-17	cytochrome P450 1A4	Gallus gallus	160-166
33961948-4	2021	In this study, we hypothesized that tumour necrosis factor-alpha (TNF-alpha), a key mediator of inflammation, modulates BaP- and PhIP-induced DNA damage in colon cancer epithelial cells.	Benzo(a)pyrene	120-123	tumor necrosis factor	Homo sapiens	66-75
33961948-5	2021	Importantly, we observed that TNF-alpha alone (0.1 to 100 pg/ml) induced DNA damage (micronuclei formation) in HCT-116 cells and co-treatment of TNF-alpha with BaP or PhIP showed higher levels of DNA damage compared to the individual single treatments.	Benzo(a)pyrene	160-163	tumor necrosis factor	Homo sapiens	30-39
33961948-5	2021	Importantly, we observed that TNF-alpha alone (0.1 to 100 pg/ml) induced DNA damage (micronuclei formation) in HCT-116 cells and co-treatment of TNF-alpha with BaP or PhIP showed higher levels of DNA damage compared to the individual single treatments.	Benzo(a)pyrene	160-163	tumor necrosis factor	Homo sapiens	145-154
33991922-4	2021	In this study, complexes of BaP with CYP1A1, CYP1B1 or CYP2C19 compound I were successfully simulated by QM/MM methods and verified by metabolic clearance, and the mutagenicity of chemicals was then predicted by the BaP-7,8-epoxide-related metabolic conformation fitness (MCF) approach, which was validated by Ames tests, showing satisfying accuracy (R2 = 0.46-0.66).	Benzo(a)pyrene	28-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	45-51
33991922-4	2021	In this study, complexes of BaP with CYP1A1, CYP1B1 or CYP2C19 compound I were successfully simulated by QM/MM methods and verified by metabolic clearance, and the mutagenicity of chemicals was then predicted by the BaP-7,8-epoxide-related metabolic conformation fitness (MCF) approach, which was validated by Ames tests, showing satisfying accuracy (R2 = 0.46-0.66).	Benzo(a)pyrene	28-31	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	55-62
33895911-8	2021	In addition, TIPE1 was found to be involved in nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, N-nitrosonornicotine and benzo[a]pyrene-mediated lung cancer through enhanced proliferation, survival and migration of lung cancer cells.	Benzo(a)pyrene	130-144	TNF alpha induced protein 8 like 1	Homo sapiens	13-18
33981385-0	2021	Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway.	Benzo(a)pyrene	17-22	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
33888111-15	2021	Both VOC-P188 solid dispersion and VOC-beta-CD inclusion compound could be prospective means for improving oral bioavailability of SA, NBP, NOL, ZL and BP in VOC.	Benzo(a)pyrene	136-138	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	39-46
33932831-1	2021	Benzo[a]pyrene (BaP), a persistent organic pollutant that may accumulate in sea sediments after oil spill or BaP chemical leakage accidents, considerably harms marine ecosystems and human health.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
33932831-1	2021	Benzo[a]pyrene (BaP), a persistent organic pollutant that may accumulate in sea sediments after oil spill or BaP chemical leakage accidents, considerably harms marine ecosystems and human health.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	109-112
33936062-4	2021	We found that BaP co-exposure potentiated Der f 1-induced TGFbeta1 secretion and signaling activation in human bronchial epithelial cells (HBECs) and the airways of asthma mouse model.	Benzo(a)pyrene	14-17	transforming growth factor beta 1	Homo sapiens	58-66
33936062-5	2021	Moreover, BaP exposure alone or co-exposure with Der f 1-induced aryl hydrocarbon receptor (AhR) activity was determined by using an AhR-dioxin-responsive element reporter plasmid.	Benzo(a)pyrene	10-13	aryl hydrocarbon receptor	Homo sapiens	65-90
33936062-5	2021	Moreover, BaP exposure alone or co-exposure with Der f 1-induced aryl hydrocarbon receptor (AhR) activity was determined by using an AhR-dioxin-responsive element reporter plasmid.	Benzo(a)pyrene	10-13	aryl hydrocarbon receptor	Homo sapiens	92-95
33936062-5	2021	Moreover, BaP exposure alone or co-exposure with Der f 1-induced aryl hydrocarbon receptor (AhR) activity was determined by using an AhR-dioxin-responsive element reporter plasmid.	Benzo(a)pyrene	10-13	aryl hydrocarbon receptor	Homo sapiens	133-136
33936062-7	2021	Furthermore, AhR knockdown led to the reduction of BaP and Der f 1 co-exposure-induced active RhoA.	Benzo(a)pyrene	51-54	aryl hydrocarbon receptor	Homo sapiens	13-16
33936062-7	2021	Furthermore, AhR knockdown led to the reduction of BaP and Der f 1 co-exposure-induced active RhoA.	Benzo(a)pyrene	51-54	ras homolog family member A	Homo sapiens	94-98
33936062-8	2021	Inhibition of RhoA signaling with fasudil, a RhoA/ROCK inhibitor, suppressed BaP and Der f 1 co-exposure-induced TGFbeta1 expression and signaling activation.	Benzo(a)pyrene	77-80	ras homolog family member A	Homo sapiens	14-18
33936062-8	2021	Inhibition of RhoA signaling with fasudil, a RhoA/ROCK inhibitor, suppressed BaP and Der f 1 co-exposure-induced TGFbeta1 expression and signaling activation.	Benzo(a)pyrene	77-80	ras homolog family member A	Homo sapiens	45-49
33936062-8	2021	Inhibition of RhoA signaling with fasudil, a RhoA/ROCK inhibitor, suppressed BaP and Der f 1 co-exposure-induced TGFbeta1 expression and signaling activation.	Benzo(a)pyrene	77-80	transforming growth factor, beta 1	Mus musculus	113-121
33394445-7	2021	Results showed that combined exposure of BONPs and BaP synergistically induced cell viability reduction, lactate dehydrogenase leakage, induction of caspases (-3 and -9) and mitochondrial membrane potential loss in GC-1 spg cells.	Benzo(a)pyrene	51-54	caspase 3	Mus musculus	149-168
33314526-8	2021	Mammary superoxide dismutase, catalase, reduced glutathione, and glutathione-S-transferase were significantly decreased in [NMU + BaP]-administered rats by 165%, 146%, 35%, and 36%, respectively.	Benzo(a)pyrene	130-133	catalase	Rattus norvegicus	30-38
33503556-0	2021	Risk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study.	Benzo(a)pyrene	60-74	prohibitin 2	Homo sapiens	76-79
33503556-1	2021	BACKGROUND: Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials.	Benzo(a)pyrene	12-26	prohibitin 2	Homo sapiens	28-31
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	64-78	angiotensin converting enzyme 2	Homo sapiens	94-98
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	64-78	angiotensin converting enzyme 2	Homo sapiens	116-120
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	80-83	angiotensin converting enzyme 2	Homo sapiens	94-98
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	80-83	angiotensin converting enzyme 2	Homo sapiens	116-120
33511555-3	2021	BaP induces an aryl hydrocarbon receptor (AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ubiquitination.	Benzo(a)pyrene	0-3	S-phase kinase associated protein 2	Homo sapiens	97-101
33511555-3	2021	BaP induces an aryl hydrocarbon receptor (AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ubiquitination.	Benzo(a)pyrene	0-3	angiotensin converting enzyme 2	Homo sapiens	106-110
33314526-6	2021	Results showed that the administration of NMU and BaP increased serum nitric oxide [NO] and myeloperoxidase [MPO] by 220% and 132%, respectively, whereas the activities of aspartate and alanine aminotransferases and level of total bilirubin remained unchanged.	Benzo(a)pyrene	50-53	myeloperoxidase	Rattus norvegicus	92-107
33314526-6	2021	Results showed that the administration of NMU and BaP increased serum nitric oxide [NO] and myeloperoxidase [MPO] by 220% and 132%, respectively, whereas the activities of aspartate and alanine aminotransferases and level of total bilirubin remained unchanged.	Benzo(a)pyrene	50-53	myeloperoxidase	Rattus norvegicus	109-112
33759217-4	2021	Herein, we employed ATR-FTIR spectroscopy to identify biomolecular changes in rat liver post-exposure to B[a]P and BDE-47 (2,2",4,4"-tetrabromodiphenyl ether) congener mixtures.	Benzo(a)pyrene	105-110	ATR serine/threonine kinase	Rattus norvegicus	20-23
33109409-5	2021	The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis.	Benzo(a)pyrene	48-51	LOC100508689	Homo sapiens	4-9
33109409-5	2021	The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis.	Benzo(a)pyrene	198-201	LOC100508689	Homo sapiens	4-9
33109409-5	2021	The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis.	Benzo(a)pyrene	198-201	LOC100508689	Homo sapiens	4-9
33109409-5	2021	The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis.	Benzo(a)pyrene	198-201	LOC100508689	Homo sapiens	4-9
33109409-5	2021	The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis.	Benzo(a)pyrene	198-201	LOC100508689	Homo sapiens	4-9
33314526-8	2021	Mammary superoxide dismutase, catalase, reduced glutathione, and glutathione-S-transferase were significantly decreased in [NMU + BaP]-administered rats by 165%, 146%, 35%, and 36%, respectively.	Benzo(a)pyrene	130-133	hematopoietic prostaglandin D synthase	Rattus norvegicus	65-90
33393179-0	2021	Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study.	Benzo(a)pyrene	23-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-52
33393179-1	2021	Benzo(a)pyrene [B(a)P], which is a carcinogen, is a substance most typically known in cigarette smoke and considered as an important intermediary of lung cancer.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-21
33750883-1	2021	Benzo [a] pyrene (BaP) in the atmosphere possess great carcinogenic potential to human health, and the understanding of its scavenging mechanisms has attracted considerable attention.	Benzo(a)pyrene	0-16	prohibitin 2	Homo sapiens	18-21
33663268-12	2021	treatment significantly prevented the BaP-mediated expression of ArR, ARNT, and CYP1A1 proteins in the mouse stomach tissue.	Benzo(a)pyrene	38-41	aryl hydrocarbon receptor nuclear translocator	Mus musculus	70-74
33663268-12	2021	treatment significantly prevented the BaP-mediated expression of ArR, ARNT, and CYP1A1 proteins in the mouse stomach tissue.	Benzo(a)pyrene	38-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	80-86
33663268-13	2021	Therefore, the present results confirm that galangin prevents BaP-induced stomach carcinogenesis probably through modulating ArR and ARNT expression in the experimental mice.	Benzo(a)pyrene	62-65	aryl hydrocarbon receptor nuclear translocator	Mus musculus	133-137
33420596-8	2021	Strains harbouring mutations in the cyp-35A2 and cyp-35A3 genes were notably less prone to BaP-mediated toxicity, and BaP led to longevity in cyp-35A5 mutants.	Benzo(a)pyrene	91-94	CYtochrome P450 family	Caenorhabditis elegans	36-44
33420596-8	2021	Strains harbouring mutations in the cyp-35A2 and cyp-35A3 genes were notably less prone to BaP-mediated toxicity, and BaP led to longevity in cyp-35A5 mutants.	Benzo(a)pyrene	91-94	CYtochrome P450 family	Caenorhabditis elegans	49-57
33420596-8	2021	Strains harbouring mutations in the cyp-35A2 and cyp-35A3 genes were notably less prone to BaP-mediated toxicity, and BaP led to longevity in cyp-35A5 mutants.	Benzo(a)pyrene	118-121	CYtochrome P450 family	Caenorhabditis elegans	142-150
33429317-4	2021	Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells).	Benzo(a)pyrene	31-45	intercellular adhesion molecule 1	Homo sapiens	138-142
33977171-0	2021	Benzo[a]pyrene Cytotoxicity Tolerance in Testicular Sertoli Cells Involves Aryl-hydrocarbon Receptor and Cytochrome P450 1A1 Expression Deficiencies.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	75-100
33977171-0	2021	Benzo[a]pyrene Cytotoxicity Tolerance in Testicular Sertoli Cells Involves Aryl-hydrocarbon Receptor and Cytochrome P450 1A1 Expression Deficiencies.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	105-124
33429317-4	2021	Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells).	Benzo(a)pyrene	31-45	bone marrow stromal cell antigen 1	Homo sapiens	143-148
33429317-4	2021	Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells).	Benzo(a)pyrene	31-45	protein tyrosine phosphatase receptor type C	Homo sapiens	149-153
33429317-4	2021	Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells).	Benzo(a)pyrene	47-50	intercellular adhesion molecule 1	Homo sapiens	138-142
33429317-4	2021	Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells).	Benzo(a)pyrene	47-50	bone marrow stromal cell antigen 1	Homo sapiens	143-148
33429317-4	2021	Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of alpha-1,6-fucosylation in CD54+CD157+CD45- cells (lung stem cells).	Benzo(a)pyrene	47-50	protein tyrosine phosphatase receptor type C	Homo sapiens	149-153
33429317-5	2021	In studies with aryl hydrocarbon receptor (AHR) antagonist, we found that these effects by BaP are independent of the canonical AHR pathway.	Benzo(a)pyrene	91-94	aryl hydrocarbon receptor	Homo sapiens	16-41
33429317-5	2021	In studies with aryl hydrocarbon receptor (AHR) antagonist, we found that these effects by BaP are independent of the canonical AHR pathway.	Benzo(a)pyrene	91-94	aryl hydrocarbon receptor	Homo sapiens	43-46
33044785-1	2021	Poly(ADP-ribose) glycohydrolase (PARG) as a main enzyme hydrolyzing poly(ADP-ribose) in eukaryotes, and its silencing can inhibit benzo(a)pyrene (BaP)-induced carcinogenesis.	Benzo(a)pyrene	130-144	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
33044785-1	2021	Poly(ADP-ribose) glycohydrolase (PARG) as a main enzyme hydrolyzing poly(ADP-ribose) in eukaryotes, and its silencing can inhibit benzo(a)pyrene (BaP)-induced carcinogenesis.	Benzo(a)pyrene	130-144	poly(ADP-ribose) glycohydrolase	Homo sapiens	33-37
33429317-6	2021	In addition, these BaP-induced fibrotic changes are reduced by TGF-beta antagonist, suggesting an alternative pathway of BaP toxicity is different from other PAH/AHR signaling pathways.	Benzo(a)pyrene	19-22	transforming growth factor alpha	Homo sapiens	63-71
33044785-1	2021	Poly(ADP-ribose) glycohydrolase (PARG) as a main enzyme hydrolyzing poly(ADP-ribose) in eukaryotes, and its silencing can inhibit benzo(a)pyrene (BaP)-induced carcinogenesis.	Benzo(a)pyrene	146-149	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
33044785-1	2021	Poly(ADP-ribose) glycohydrolase (PARG) as a main enzyme hydrolyzing poly(ADP-ribose) in eukaryotes, and its silencing can inhibit benzo(a)pyrene (BaP)-induced carcinogenesis.	Benzo(a)pyrene	146-149	poly(ADP-ribose) glycohydrolase	Homo sapiens	33-37
33044785-2	2021	A thorough understanding of the mechanism of PARG silenced inhibition of BaP-induced carcinogenesis provides a new therapeutic target for the prevention and treatment of environmental hazard induced lung cancer.	Benzo(a)pyrene	73-76	poly(ADP-ribose) glycohydrolase	Homo sapiens	45-49
33429317-6	2021	In addition, these BaP-induced fibrotic changes are reduced by TGF-beta antagonist, suggesting an alternative pathway of BaP toxicity is different from other PAH/AHR signaling pathways.	Benzo(a)pyrene	19-22	aryl hydrocarbon receptor	Homo sapiens	162-165
33044785-7	2021	Analysis of the Kaplan-Meier plotter database indicated that high H2B levels predicted low survival in all LC patients suggesting that H2B could be a new biomarker for determining the prognosis of the LC, and that its expression can be inhibited by PARG silencing in BaP-induced carcinogenesis.	Benzo(a)pyrene	267-270	H2B clustered histone 21	Homo sapiens	66-69
33429317-6	2021	In addition, these BaP-induced fibrotic changes are reduced by TGF-beta antagonist, suggesting an alternative pathway of BaP toxicity is different from other PAH/AHR signaling pathways.	Benzo(a)pyrene	121-124	transforming growth factor alpha	Homo sapiens	63-71
33044785-7	2021	Analysis of the Kaplan-Meier plotter database indicated that high H2B levels predicted low survival in all LC patients suggesting that H2B could be a new biomarker for determining the prognosis of the LC, and that its expression can be inhibited by PARG silencing in BaP-induced carcinogenesis.	Benzo(a)pyrene	267-270	poly(ADP-ribose) glycohydrolase	Homo sapiens	249-253
33429317-7	2021	Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells.	Benzo(a)pyrene	30-33	intercellular adhesion molecule 1	Homo sapiens	98-102
33429317-7	2021	Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells.	Benzo(a)pyrene	30-33	bone marrow stromal cell antigen 1	Homo sapiens	103-108
33429317-7	2021	Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells.	Benzo(a)pyrene	30-33	protein tyrosine phosphatase receptor type C	Homo sapiens	109-113
33429317-7	2021	Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells.	Benzo(a)pyrene	138-141	intercellular adhesion molecule 1	Homo sapiens	98-102
33429317-7	2021	Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells.	Benzo(a)pyrene	138-141	bone marrow stromal cell antigen 1	Homo sapiens	103-108
33429317-7	2021	Finally, it was observed that BaP impairs the spheroid formation and the podoplanin expression of CD54+CD157+CD45- cells, indicating that BaP suppresses the differentiation of lung stem cells.	Benzo(a)pyrene	138-141	protein tyrosine phosphatase receptor type C	Homo sapiens	109-113
33429317-8	2021	Taken together, our findings reveal specific BaP-induced injuries in CD54+CD157+CD45- cells.	Benzo(a)pyrene	45-48	intercellular adhesion molecule 1	Homo sapiens	69-73
33429317-8	2021	Taken together, our findings reveal specific BaP-induced injuries in CD54+CD157+CD45- cells.	Benzo(a)pyrene	45-48	bone marrow stromal cell antigen 1	Homo sapiens	74-79
33429317-8	2021	Taken together, our findings reveal specific BaP-induced injuries in CD54+CD157+CD45- cells.	Benzo(a)pyrene	45-48	protein tyrosine phosphatase receptor type C	Homo sapiens	80-84
33288249-0	2021	Aryl hydrocarbon receptor mediates benzo[a]pyrene-induced metabolic reprogramming in human lung epithelial BEAS-2B cells.	Benzo(a)pyrene	35-49	aryl hydrocarbon receptor	Homo sapiens	0-25
33045463-2	2021	The half-life of BaP was 4.7 and 2.3 weeks for biofilms on the inorganic carrier (BCINOR, montmorillonite) and on the organic carrier (BCOR, humic acid), respectively.	Benzo(a)pyrene	17-20	BCL6 corepressor	Homo sapiens	135-139
33053472-7	2021	Beside, in contrast to TPU-BP composite, the release rate of toxic smoke and CO gas of TPU-GNS/MA/BP-2 composite are reduced by 46.7% and 49.4%.	Benzo(a)pyrene	27-29	BP2	Homo sapiens	98-102
33022458-4	2021	Combinations of BaP and C60 showed antagonistic effects for lysosomal stability, mTORC1 (mechanistic target of rapamycin complex 1) inhibition and intralysosomal lipid (5 & 50mug/L BaP).	Benzo(a)pyrene	16-19	CREB regulated transcription coactivator 1	Mus musculus	81-87
33288249-3	2021	However, how AHR reprograms metabolism related to the malignant transformation in of benzo[a]pyrene (BaP)-exposed lung cells remains unclear.	Benzo(a)pyrene	85-99	aryl hydrocarbon receptor	Homo sapiens	13-16
33288249-3	2021	However, how AHR reprograms metabolism related to the malignant transformation in of benzo[a]pyrene (BaP)-exposed lung cells remains unclear.	Benzo(a)pyrene	101-104	aryl hydrocarbon receptor	Homo sapiens	13-16
33288249-4	2021	After confirming that BaP exposure activated AHR signaling and relevant downstream factors and then promoted epithelial-mesenchymal transition, an untargeted metabolomics approach was employed to discover AHR-mediated metabolic reprogramming and potential therapeutic targets in BaP-exposed BEAS-2B cells.	Benzo(a)pyrene	22-25	aryl hydrocarbon receptor	Homo sapiens	45-48
33288249-4	2021	After confirming that BaP exposure activated AHR signaling and relevant downstream factors and then promoted epithelial-mesenchymal transition, an untargeted metabolomics approach was employed to discover AHR-mediated metabolic reprogramming and potential therapeutic targets in BaP-exposed BEAS-2B cells.	Benzo(a)pyrene	279-282	aryl hydrocarbon receptor	Homo sapiens	205-208
33288249-8	2021	Besides, levels of amino acids and fatty acids were highly correlated with those of many metabolites and AHR signaling upon BaP exposure and RSV intervention (the absolute values of Pearson correlation coefficients above 0.8).	Benzo(a)pyrene	124-127	aryl hydrocarbon receptor	Homo sapiens	105-108
33288249-9	2021	We further discovered a decrease in peroxisome proliferator-activated receptor (PPAR) A/G signaling and an increase in fatty acid import by the transporter FATP1 in BaP-exposed BEAS-2B cells.	Benzo(a)pyrene	165-168	peroxisome proliferator activated receptor alpha	Homo sapiens	36-87
33288249-9	2021	We further discovered a decrease in peroxisome proliferator-activated receptor (PPAR) A/G signaling and an increase in fatty acid import by the transporter FATP1 in BaP-exposed BEAS-2B cells.	Benzo(a)pyrene	165-168	solute carrier family 27 member 1	Homo sapiens	156-161
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	Benzo(a)pyrene	64-67	aryl hydrocarbon receptor	Homo sapiens	27-30
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	Benzo(a)pyrene	64-67	peroxisome proliferator activated receptor alpha	Homo sapiens	90-95
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	Benzo(a)pyrene	64-67	solute carrier family 27 member 1	Homo sapiens	126-131
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	Benzo(a)pyrene	64-67	aryl hydrocarbon receptor	Homo sapiens	187-190
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	Benzo(a)pyrene	64-67	peroxisome proliferator activated receptor alpha	Homo sapiens	242-247
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	Benzo(a)pyrene	64-67	solute carrier family 27 member 1	Homo sapiens	250-255
33288249-11	2021	These data suggested amino acid and fatty acid metabolism, AHR and PPAR-FATP1 signaling as potential therapeutic targets for intervening BaP-induced toxicity and related diseases.	Benzo(a)pyrene	137-140	aryl hydrocarbon receptor	Homo sapiens	59-62
33288249-11	2021	These data suggested amino acid and fatty acid metabolism, AHR and PPAR-FATP1 signaling as potential therapeutic targets for intervening BaP-induced toxicity and related diseases.	Benzo(a)pyrene	137-140	peroxisome proliferator activated receptor alpha	Homo sapiens	67-71
33288249-11	2021	These data suggested amino acid and fatty acid metabolism, AHR and PPAR-FATP1 signaling as potential therapeutic targets for intervening BaP-induced toxicity and related diseases.	Benzo(a)pyrene	137-140	solute carrier family 27 member 1	Homo sapiens	72-77
33288249-12	2021	As far as we known, fatty acid accumulation and high correlations of AHR signaling with amino acid and fatty acid metabolism are novel phenomena discovered in BaP-exposed lung epithelial cells.	Benzo(a)pyrene	159-162	aryl hydrocarbon receptor	Homo sapiens	69-72
33422967-8	2021	Benzo[e]pyrene, benzo[a]pyrene and other related chemicals were the most likely to bind to PPARgamma.	Benzo(a)pyrene	16-30	peroxisome proliferator activated receptor gamma	Homo sapiens	91-100
33278487-0	2021	Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP.	Benzo(a)pyrene	130-133	aryl hydrocarbon receptor	Homo sapiens	97-100
33530556-3	2021	The yeast mitochondrial membrane potential, as indicated by tetramethylrhodamine methyl ester signals, dissipated over 2-4 h after treatment of cells with 5 muM BP, which was sensitive to cyclosporin A (CsA) and Cpr3 deficiency and blocked by porin1/2 deficiency.	Benzo(a)pyrene	161-163	peptidylprolyl isomerase CPR3	Saccharomyces cerevisiae S288C	212-216
33530556-6	2021	These data suggest that, upon BP treatment, yeast can form a porin1/2- and Cpr3-regulated PTP, which is mediated by AACs but not by ATP synthase dimers.	Benzo(a)pyrene	30-32	peptidylprolyl isomerase CPR3	Saccharomyces cerevisiae S288C	75-79
33393578-1	2021	Benzo[a]pyrene (Bap) is one of the main organic pollutants in the atmospheric haze that is rich in fine water drops and particulate matters.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
33467586-8	2021	BP had higher monounsaturated fatty acids (MUFA) content, but CP had higher polyunsaturated fatty acids (PUFA) content (p < 0.05).	Benzo(a)pyrene	0-2	Monounsaturated fatty acid percentage	Sus scrofa	43-47
33436873-4	2021	The efficiency for the detection increased in the sequence of Na-BP < BP < K-BP < Li-BP, with the most significant improvement of + 95.2% in the case of Li doping.	Benzo(a)pyrene	65-67	kinesin family binding protein	Homo sapiens	75-79
33411230-9	2021	The phase I biotransformation enzymes, CYP1A1 and 1B1, showed BaP concentration-dependent expression.	Benzo(a)pyrene	62-65	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-53
33245929-8	2021	BP group also showed decreased CD83+ cells, CD8+ cells and increased number of CD166+ cells.	Benzo(a)pyrene	0-2	CD83 antigen	Mus musculus	31-35
33245929-8	2021	BP group also showed decreased CD83+ cells, CD8+ cells and increased number of CD166+ cells.	Benzo(a)pyrene	0-2	activated leukocyte cell adhesion molecule	Mus musculus	79-84
33790107-4	2021	We showed that treatments with 3MC, BaP, and DMBA strongly suppressed mammosphere formation of the stem cells in an AHR-dependent manner, while other agonists showed weaker suppression.	Benzo(a)pyrene	36-39	aryl hydrocarbon receptor	Homo sapiens	116-119
33297042-1	2021	Benzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction.	Benzo(a)pyrene	0-14	steroidogenic acute regulatory protein	Rattus norvegicus	151-155
33297042-1	2021	Benzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction.	Benzo(a)pyrene	16-19	steroidogenic acute regulatory protein	Rattus norvegicus	151-155
33297115-0	2021	A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.	Benzo(a)pyrene	65-79	H3 histone pseudogene 16	Homo sapiens	88-91
33297115-7	2021	Since BaP decreased cell proliferative rate via induction of p21 expression, we generated the A549 cell model with reduced p21 expression and exposed it to BaP for two weeks.	Benzo(a)pyrene	6-9	H3 histone pseudogene 16	Homo sapiens	61-64
33158619-11	2021	In addition, we also found that the expression of DOT1L, the only methyltransferase in H3K79, was repressed by BaP dose-dependently.	Benzo(a)pyrene	111-114	DOT1 like histone lysine methyltransferase	Homo sapiens	50-55
33158619-12	2021	DOT1L knockdown resulted in decreased H3K79me2 level and aggravated DNA damage after BaP exposure.	Benzo(a)pyrene	85-88	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
33158619-13	2021	This suggests that BaP induces H3K79me2 repression via inhibiting DOT1L expression.	Benzo(a)pyrene	19-22	DOT1 like histone lysine methyltransferase	Homo sapiens	66-71
33249052-9	2021	Mixtures containing BP caused a strong decrease of CAR transactivation in line with lower CYP2B6 expression.	Benzo(a)pyrene	20-22	nuclear receptor subfamily 1 group I member 3	Homo sapiens	51-54
33249052-9	2021	Mixtures containing BP caused a strong decrease of CAR transactivation in line with lower CYP2B6 expression.	Benzo(a)pyrene	20-22	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	90-96
33408298-5	2021	CYP3A5 mRNA expression was induced by the polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (3MC) and benzo[a]pyrene in HepG2 cells.	Benzo(a)pyrene	121-135	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	0-6
33080227-4	2020	Here, we show that serotonin (5-HT), via its receptor HTR2A, promotes BP proliferation in an evolutionarily relevant manner.	Benzo(a)pyrene	70-72	5-hydroxytryptamine receptor 2A	Homo sapiens	54-59
33080227-6	2020	However, ectopic HTR2A expression can increase mouse BP proliferation.	Benzo(a)pyrene	53-55	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	17-22
33080227-7	2020	Conversely, CRISPR/Cas9-mediated knockout of endogenous HTR2A in embryonic ferret Ncx reduces BP proliferation.	Benzo(a)pyrene	94-96	5-hydroxytryptamine receptor 2A	Mustela putorius furo	56-61
33080227-8	2020	Pharmacological activation of endogenous HTR2A in fetal human Ncx ex vivo increases BP proliferation via HER2/ERK signaling.	Benzo(a)pyrene	84-86	5-hydroxytryptamine receptor 2A	Homo sapiens	41-46
33349622-6	2020	Using known mammalian AhR modulators we found that, ahr-1 protects against environmental insults (benzo(a)pyrene and UVB light) and identified a new role for AhR-bacterial diet interaction in animal lifespan, stress resistance, and age-associated pathologies.	Benzo(a)pyrene	98-112	aryl hydrocarbon receptor	Homo sapiens	22-25
33324084-0	2020	Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.	Benzo(a)pyrene	100-103	fatty acid synthase	Mus musculus	43-62
33324084-0	2020	Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.	Benzo(a)pyrene	100-103	fatty acid synthase	Mus musculus	64-68
33166399-0	2020	Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence.	Benzo(a)pyrene	0-14	E2F transcription factor 1 L homeolog	Xenopus laevis	52-56
33166399-0	2020	Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence.	Benzo(a)pyrene	0-14	E2F transcription factor 4 S homeolog	Xenopus laevis	57-61
33166399-2	2020	Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch repair (MMR) genes (MSH2, MSH6, EXO1) and of RAD51, the central homologous recombination repair (HR) component, ultimately leading to downregulation of MMR and HR.	Benzo(a)pyrene	56-70	mutS homolog 2 L homeolog	Xenopus laevis	192-196
33166399-2	2020	Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch repair (MMR) genes (MSH2, MSH6, EXO1) and of RAD51, the central homologous recombination repair (HR) component, ultimately leading to downregulation of MMR and HR.	Benzo(a)pyrene	56-70	mutS homolog 6 L homeolog	Xenopus laevis	198-202
33166399-2	2020	Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch repair (MMR) genes (MSH2, MSH6, EXO1) and of RAD51, the central homologous recombination repair (HR) component, ultimately leading to downregulation of MMR and HR.	Benzo(a)pyrene	56-70	exonuclease 1 S homeolog	Xenopus laevis	204-208
33166399-2	2020	Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch repair (MMR) genes (MSH2, MSH6, EXO1) and of RAD51, the central homologous recombination repair (HR) component, ultimately leading to downregulation of MMR and HR.	Benzo(a)pyrene	56-70	RAD51 recombinase L homeolog	Xenopus laevis	217-222
32994205-6	2020	Moreover, PKCepsilon-knockout mice were found to be less susceptible to lung tumorigenesis induced by benzo[a]pyrene, a carcinogen that induces mutations in Kras.	Benzo(a)pyrene	102-116	protein kinase C, epsilon	Mus musculus	10-20
33324084-7	2020	A significant drop was observed in BaP-induced tumor marker enzymes (ADA, AHH, gamma-GT, LDH) in the serum of the mice treated with DAS.	Benzo(a)pyrene	35-38	adenosine deaminase	Mus musculus	69-72
33324084-7	2020	A significant drop was observed in BaP-induced tumor marker enzymes (ADA, AHH, gamma-GT, LDH) in the serum of the mice treated with DAS.	Benzo(a)pyrene	35-38	aryl-hydrocarbon receptor	Mus musculus	74-77
33324084-8	2020	Moreover, DAS treatment resulted in the recovery of antioxidant enzymes, SOD and CAT, in BaP-exposed mice.	Benzo(a)pyrene	89-92	catalase	Mus musculus	81-84
33324084-10	2020	The immunohistochemical analysis revealed the up-regulation of fatty acid synthase (FASN) in the lungs and liver tissues of BaP-exposed mice and the treatment with DAS inhibited FASN expression.	Benzo(a)pyrene	124-127	fatty acid synthase	Mus musculus	63-82
33324084-10	2020	The immunohistochemical analysis revealed the up-regulation of fatty acid synthase (FASN) in the lungs and liver tissues of BaP-exposed mice and the treatment with DAS inhibited FASN expression.	Benzo(a)pyrene	124-127	fatty acid synthase	Mus musculus	84-88
33324084-12	2020	To the best of our knowledge, this is the first study that describes the role of FASN in BaP-induced lung carcinogenesis.	Benzo(a)pyrene	89-92	fatty acid synthase	Mus musculus	81-85
32808713-1	2020	Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	112-137
32808713-1	2020	Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	139-142
32808713-1	2020	Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	112-137
32808713-1	2020	Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway.	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	139-142
32808713-7	2020	In addition, FICZ ameliorated B[a]P-induced apoptosis by inhibiting reactive oxygen species generation and caspase3 activation, as well as increasing reduced glutathione level in mitochondria.	Benzo(a)pyrene	30-35	caspase 3	Mus musculus	107-115
33213213-2	2020	The toxicity of PAHs, which include benzo(alpha)pyrene (BP), is mediated by the activation of R450 cytochromes of the 1A subfamily (CYP1A1 and CYP1A2).	Benzo(a)pyrene	56-58	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	132-138
33213213-2	2020	The toxicity of PAHs, which include benzo(alpha)pyrene (BP), is mediated by the activation of R450 cytochromes of the 1A subfamily (CYP1A1 and CYP1A2).	Benzo(a)pyrene	56-58	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	143-149
33227946-9	2020	In summary, Thalassia testudinum metabolites exhibit antigenotoxic activity mediated, at least, by the inhibition of CYP1A1-mediated BP biotransformation, arresting the oxidative and mutagenic damage.	Benzo(a)pyrene	133-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
33304900-10	2020	In a whole-embryo cultured mouse model, hypomethylation of the Zic4 promoter region and 5" UTR and upregulation of Zic4 were observed, coupled with increased NTD rates after BaP exposure.	Benzo(a)pyrene	174-177	zinc finger protein of the cerebellum 4	Mus musculus	63-67
33304900-10	2020	In a whole-embryo cultured mouse model, hypomethylation of the Zic4 promoter region and 5" UTR and upregulation of Zic4 were observed, coupled with increased NTD rates after BaP exposure.	Benzo(a)pyrene	174-177	zinc finger protein of the cerebellum 4	Mus musculus	115-119
32994205-6	2020	Moreover, PKCepsilon-knockout mice were found to be less susceptible to lung tumorigenesis induced by benzo[a]pyrene, a carcinogen that induces mutations in Kras.	Benzo(a)pyrene	102-116	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	157-161
32554009-7	2020	While fluoranthene and phenanthrene strongly reduced human AhR and AR transactivation, benzo [a]pyrene strongly activated AhR and ER, but inhibited GR and AR.	Benzo(a)pyrene	87-102	aryl hydrocarbon receptor	Homo sapiens	122-125
32554009-8	2020	In human breast cancer cells, benzo [a]pyrene dramatically activated AhR, inducing a 10-fold higher response than 2,3,7,8-tetrachlorodibenzodioxin (TCDD) at concentrations possibly found realistically in human blood.	Benzo(a)pyrene	30-45	aryl hydrocarbon receptor	Homo sapiens	69-72
32854063-1	2020	Benzo[a]pyrene (BaP) is a hazardous compound for human health and for environmental compartments.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
32882578-8	2020	When we compared the expression of PKC isozymes, we found that the protein and mRNA expression of several isozymes was significantly decreased in the PFC (i.e., PKCalpha, PKCbetaI, PKCbetaII and PKCepsilon) and TEMP (i.e., PKCalpha, PKCbetaI, PKCbetaII, PKCepsilon and PKCgamma) of BP subjects, but not in the CING.	Benzo(a)pyrene	282-284	proline rich transmembrane protein 2	Homo sapiens	35-38
32557721-0	2020	Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation.	Benzo(a)pyrene	43-57	aryl-hydrocarbon receptor	Mus musculus	14-39
32557721-0	2020	Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation.	Benzo(a)pyrene	43-57	interleukin 33	Mus musculus	68-82
32557721-1	2020	We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis.	Benzo(a)pyrene	30-44	aryl-hydrocarbon receptor	Mus musculus	56-81
32557721-1	2020	We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis.	Benzo(a)pyrene	30-44	aryl-hydrocarbon receptor	Mus musculus	83-86
32557721-1	2020	We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis.	Benzo(a)pyrene	46-49	aryl-hydrocarbon receptor	Mus musculus	56-81
32557721-1	2020	We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis.	Benzo(a)pyrene	46-49	aryl-hydrocarbon receptor	Mus musculus	83-86
32557721-2	2020	The present study aimed to determine whether BaP-induced AhR activation results in development of airway inflammation.	Benzo(a)pyrene	45-48	aryl-hydrocarbon receptor	Mus musculus	57-60
32557721-8	2020	Results indicated that pre-treatment with BaP increased expression of IL-8 in house dust mite-activated EOL-1, BEAS-2B, and A549 cells.	Benzo(a)pyrene	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
32557721-9	2020	In addition, IL-33 levels in BEAS-2B cells were significantly increased after BaP exposure.	Benzo(a)pyrene	78-81	interleukin 33	Homo sapiens	13-18
32557721-10	2020	Our findings indicated that BaP-induced AhR activation is involved in the pro-inflammatory response in respiratory allergy, and that this effect may be mediated by increased IL-33 expression and eosinophil infiltration.	Benzo(a)pyrene	28-31	aryl hydrocarbon receptor	Homo sapiens	40-43
32557721-10	2020	Our findings indicated that BaP-induced AhR activation is involved in the pro-inflammatory response in respiratory allergy, and that this effect may be mediated by increased IL-33 expression and eosinophil infiltration.	Benzo(a)pyrene	28-31	interleukin 33	Homo sapiens	174-179
32992293-0	2020	Estrogen receptor-dependent and independent roles of benzo[a]pyrene in Ishikawa cells.	Benzo(a)pyrene	53-67	estrogen receptor 1	Homo sapiens	0-17
32882578-10	2020	Our results show that there is a region-specific decrease of certain PKC isozymes in the membrane and cytosol fractions of BP but not SZ subjects.	Benzo(a)pyrene	123-125	proline rich transmembrane protein 2	Homo sapiens	69-72
32898529-4	2020	We tried to evaluate the synergistic role of IL-27 and IL-28B in modulation of BaP-induced lung carcinogenesis associated with various hallmarks like pulmonary redox imbalance, angiogenesis, inflammation and cell proliferation in lung tissue.	Benzo(a)pyrene	79-82	interleukin 27	Mus musculus	45-50
32898529-4	2020	We tried to evaluate the synergistic role of IL-27 and IL-28B in modulation of BaP-induced lung carcinogenesis associated with various hallmarks like pulmonary redox imbalance, angiogenesis, inflammation and cell proliferation in lung tissue.	Benzo(a)pyrene	79-82	interferon lambda 3	Mus musculus	55-61
32898529-12	2020	SIGNIFICANCE: Results hinted that IL-27 along with IL-28B were able to ameliorate various hallmarks ranging from angiogenesis to inflammation associated with the BaP-induced lung carcinogenesis.	Benzo(a)pyrene	162-165	interleukin 27	Mus musculus	34-39
32898529-12	2020	SIGNIFICANCE: Results hinted that IL-27 along with IL-28B were able to ameliorate various hallmarks ranging from angiogenesis to inflammation associated with the BaP-induced lung carcinogenesis.	Benzo(a)pyrene	162-165	interferon lambda 3	Mus musculus	51-57
33123590-8	2020	Conclusions: Our study results provide mechanistic insight to the effect of BPDE on trophoblast dysfunction through enhanced cell apoptosis and inhibited migration, providing further experimental evidence to the causative links between BaP exposure and PRL.	Benzo(a)pyrene	236-239	prolactin	Homo sapiens	253-256
32684523-0	2020	Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal stem cells through AhR reducing BMPRII.	Benzo(a)pyrene	0-14	bone morphogenetic protein 2	Mus musculus	23-27
32684523-0	2020	Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal stem cells through AhR reducing BMPRII.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	97-100
32684523-0	2020	Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal stem cells through AhR reducing BMPRII.	Benzo(a)pyrene	0-14	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	110-116
32684523-1	2020	Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	15-18
32684523-1	2020	Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	158-183
32684523-1	2020	Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	185-188
32840350-5	2020	Col10a1:nlGFP and osx:mCherry were identified as potential targets of epigenetic modifications underlying the transgenerational inheritance of BaP bone toxicity.	Benzo(a)pyrene	143-146	collagen, type X, alpha 1a	Oryzias latipes	0-7
32758941-0	2020	GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients.	Benzo(a)pyrene	42-56	G protein-coupled receptor, family C, group 5, member A	Mus musculus	0-6
32758941-6	2020	BaP exposure enhanced bleomycin (BLM)-induced murine pulmonary fibrosis with increased Fibronectin and alpha-SMA expression in primary fibroblasts, thickened respiratory membrane and damaged alveolar type II cell, combined with Gprc5a decline in fibrotic mass.	Benzo(a)pyrene	0-3	fibronectin 1	Mus musculus	87-98
32758941-6	2020	BaP exposure enhanced bleomycin (BLM)-induced murine pulmonary fibrosis with increased Fibronectin and alpha-SMA expression in primary fibroblasts, thickened respiratory membrane and damaged alveolar type II cell, combined with Gprc5a decline in fibrotic mass.	Benzo(a)pyrene	0-3	actin alpha 2, smooth muscle, aorta	Mus musculus	103-112
32758941-6	2020	BaP exposure enhanced bleomycin (BLM)-induced murine pulmonary fibrosis with increased Fibronectin and alpha-SMA expression in primary fibroblasts, thickened respiratory membrane and damaged alveolar type II cell, combined with Gprc5a decline in fibrotic mass.	Benzo(a)pyrene	0-3	G protein-coupled receptor, family C, group 5, member A	Mus musculus	228-234
32758941-7	2020	GPRC5A mRNA reduced after 10-14 days" BaP exposure in human epithelial cell A549.	Benzo(a)pyrene	38-41	G protein-coupled receptor class C group 5 member A	Homo sapiens	0-6
32758941-13	2020	Pollutant BaP exposure worsens murine fibrosis and myofibroblast activation via GPRC5A reduction in the damaged epithelium.	Benzo(a)pyrene	10-13	G protein-coupled receptor, family C, group 5, member A	Mus musculus	80-86
32255272-0	2020	Sub-chronic administration of benzo[a]pyrene disrupts hippocampal long-term potentiation via inhibiting CaMK II/PKC/PKA-ERK-CREB signaling in rats.	Benzo(a)pyrene	30-44	protein kinase C, gamma	Rattus norvegicus	112-115
32615350-8	2020	AhR-knock-down significantly reduced the cardiovascular toxicity of 6H-BPO and its binary mixture with BaP indicating a significant AhR-dependence of the effects.	Benzo(a)pyrene	103-106	aryl hydrocarbon receptor 1a	Danio rerio	0-3
32615350-8	2020	AhR-knock-down significantly reduced the cardiovascular toxicity of 6H-BPO and its binary mixture with BaP indicating a significant AhR-dependence of the effects.	Benzo(a)pyrene	103-106	aryl hydrocarbon receptor 1a	Danio rerio	132-135
32615350-9	2020	Measurements of internal concentrations showed that the toxicokinetics of BaP and 6H-BPO were altered in the binary mixture compared to the single compound exposure, and most likely due to CYP1 inhibition by 6H-BPO.	Benzo(a)pyrene	74-77	peptidylprolyl isomerase Aa (cyclophilin A)	Danio rerio	189-193
32791654-0	2020	Corrigendum to "Resveratrol prevents benzo(a)pyrene-induced disruption of mitochondrial homeostasis via the AMPK signaling pathway in primary cultured neurons" [Environ.	Benzo(a)pyrene	37-51	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	108-112
32592928-8	2020	The transcript levels of il6, il8, il10 and ifnphi1 were significantly increased in zebrafish, however not in mosquitofish, following Bap exposure.	Benzo(a)pyrene	134-137	interleukin 6 (interferon, beta 2)	Danio rerio	25-28
32592928-8	2020	The transcript levels of il6, il8, il10 and ifnphi1 were significantly increased in zebrafish, however not in mosquitofish, following Bap exposure.	Benzo(a)pyrene	134-137	chemokine (C-X-C motif) ligand 8a	Danio rerio	30-33
32592928-8	2020	The transcript levels of il6, il8, il10 and ifnphi1 were significantly increased in zebrafish, however not in mosquitofish, following Bap exposure.	Benzo(a)pyrene	134-137	interleukin 10	Danio rerio	35-39
32592928-8	2020	The transcript levels of il6, il8, il10 and ifnphi1 were significantly increased in zebrafish, however not in mosquitofish, following Bap exposure.	Benzo(a)pyrene	134-137	interferon phi 1	Danio rerio	44-51
32730838-6	2020	3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1.	Benzo(a)pyrene	56-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	132-138
32730838-6	2020	3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1.	Benzo(a)pyrene	56-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
32140951-2	2020	We compared the changes in the bone metabolism of each part of bone in response to BP treatment by performing a quantitative analysis of bone scintigraphy images between patients treated with low-dose BP for osteoporosis (LBP group; n = 17), those treated with high-dose BP for metastatic bone tumor (HBP group; n = 11), and patients with other oral disease who required bone scintigraphy, with no history of BP treatment (control group; n = 40).	Benzo(a)pyrene	83-85	heme binding protein 1	Homo sapiens	301-304
32417428-6	2020	Compared to BaP, exposure to COR resulted in less activation of the aryl hydrocarbon receptor (AhR) and thus less induction of hepatic cytochrome P450 1a (Cyp1a) enzymes, which play a critical role in metabolism of both COR and BaP.	Benzo(a)pyrene	12-15	aryl-hydrocarbon receptor	Mus musculus	68-93
32717239-4	2020	Forkhead box protein A1 (FOXA1) was selected and evaluated for its potential role in BaP-induced carcinogenesis in vitro and in vivo.	Benzo(a)pyrene	85-88	forkhead box A1	Homo sapiens	0-23
32717239-4	2020	Forkhead box protein A1 (FOXA1) was selected and evaluated for its potential role in BaP-induced carcinogenesis in vitro and in vivo.	Benzo(a)pyrene	85-88	forkhead box A1	Mus musculus	25-30
32717239-11	2020	Our findings revealed oncogenic role of FOXA1 in BaP-induced lung cancer and improved understanding of mechanism in BaP-induced carcinogenesis.	Benzo(a)pyrene	49-52	forkhead box A1	Homo sapiens	40-45
32911594-10	2020	The mean concentrations of benzo[a]pyrene (BaP), a carcinogenic marker of PAHs, were 10.3 and 0.05 ng/m3 in the heating and non-heating seasons, respectively.	Benzo(a)pyrene	27-41	prohibitin 2	Homo sapiens	43-46
32255272-0	2020	Sub-chronic administration of benzo[a]pyrene disrupts hippocampal long-term potentiation via inhibiting CaMK II/PKC/PKA-ERK-CREB signaling in rats.	Benzo(a)pyrene	30-44	Eph receptor B1	Rattus norvegicus	120-123
32255272-0	2020	Sub-chronic administration of benzo[a]pyrene disrupts hippocampal long-term potentiation via inhibiting CaMK II/PKC/PKA-ERK-CREB signaling in rats.	Benzo(a)pyrene	30-44	cAMP responsive element binding protein 1	Rattus norvegicus	124-128
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	microRNA 34a	Homo sapiens	100-107
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	microRNA 150	Homo sapiens	109-116
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	microRNA 155	Homo sapiens	122-129
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	nuclear factor kappa B subunit 1	Homo sapiens	166-178
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	180-183
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	tumor protein p53	Homo sapiens	189-192
32588678-7	2020	The exposure of BaP also caused significant alterations in the expression of epigenetic modifiers (DNMT1, HDAC1, HDAC7, KDM3a, EZH2, and P300) and hypomethylation within nuclear and mitochondrial DNA.	Benzo(a)pyrene	16-19	DNA methyltransferase 1	Homo sapiens	99-104
32588678-7	2020	The exposure of BaP also caused significant alterations in the expression of epigenetic modifiers (DNMT1, HDAC1, HDAC7, KDM3a, EZH2, and P300) and hypomethylation within nuclear and mitochondrial DNA.	Benzo(a)pyrene	16-19	histone deacetylase 1	Homo sapiens	106-111
32588678-7	2020	The exposure of BaP also caused significant alterations in the expression of epigenetic modifiers (DNMT1, HDAC1, HDAC7, KDM3a, EZH2, and P300) and hypomethylation within nuclear and mitochondrial DNA.	Benzo(a)pyrene	16-19	histone deacetylase 7	Homo sapiens	113-118
32588678-7	2020	The exposure of BaP also caused significant alterations in the expression of epigenetic modifiers (DNMT1, HDAC1, HDAC7, KDM3a, EZH2, and P300) and hypomethylation within nuclear and mitochondrial DNA.	Benzo(a)pyrene	16-19	lysine demethylase 3A	Homo sapiens	120-125
32588678-7	2020	The exposure of BaP also caused significant alterations in the expression of epigenetic modifiers (DNMT1, HDAC1, HDAC7, KDM3a, EZH2, and P300) and hypomethylation within nuclear and mitochondrial DNA.	Benzo(a)pyrene	16-19	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	127-131
32588678-7	2020	The exposure of BaP also caused significant alterations in the expression of epigenetic modifiers (DNMT1, HDAC1, HDAC7, KDM3a, EZH2, and P300) and hypomethylation within nuclear and mitochondrial DNA.	Benzo(a)pyrene	16-19	E1A binding protein p300	Homo sapiens	137-141
32773350-0	2020	CYP2 C9 polymorphism among patients with oral squamous cell carcinoma and its role in altering the metabolism of benzo[a]pyrene.	Benzo(a)pyrene	113-127	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-7
32773350-2	2020	We also investigated the interaction between CYP2 C9 wild type and the polymorphic variants with benzo[a]pyrene by using molecular docking analysis.	Benzo(a)pyrene	97-111	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	45-52
32773350-5	2020	Molecular docking was then carried out to determine the interaction of CYP2 C9*1, CYP2 C9*2, and CYP2 C9*3 with benzo[a]pyrene.	Benzo(a)pyrene	112-126	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	71-78
32773350-5	2020	Molecular docking was then carried out to determine the interaction of CYP2 C9*1, CYP2 C9*2, and CYP2 C9*3 with benzo[a]pyrene.	Benzo(a)pyrene	112-126	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	82-89
32773350-5	2020	Molecular docking was then carried out to determine the interaction of CYP2 C9*1, CYP2 C9*2, and CYP2 C9*3 with benzo[a]pyrene.	Benzo(a)pyrene	112-126	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	82-89
32773350-8	2020	The docking analysis showed benzo[a]pyrene to bind specifically to the altered single nucleotide catalytic site in the polymorphic CYP2 C9*3 enzyme.	Benzo(a)pyrene	28-42	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	131-138
32773350-10	2020	The modified docking of CYP2 C9*3 with benzo[a]pyrene signifies altered metabolism in vivo.	Benzo(a)pyrene	39-53	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-31
32867800-4	2020	METHODS: BaP or vehicle was administered to 4-month-old APPswe/PS1dE9 transgenic (APP/PS1) mice and wildtype (WT) mice for 2 months.	Benzo(a)pyrene	9-12	presenilin 1	Mus musculus	63-66
32867800-10	2020	Treatment of primary neuron-glia cultures with aged Abeta (a mixture of monomers, oligomers, and fibrils) and/or BaP was used to investigate mechanisms by which BaP enhanced Abeta-induced neurodegeneration.	Benzo(a)pyrene	161-164	amyloid beta (A4) precursor protein	Mus musculus	174-179
32867800-11	2020	RESULTS: BaP exposure induced progressive decline in spatial learning/memory and exploratory behaviors in APP/PS1 mice and WT mice, and APP/PS1 mice showed severer behavioral deficits than WT mice.	Benzo(a)pyrene	9-12	presenilin 1	Mus musculus	110-113
32867800-12	2020	Moreover, BaP exposure promoted neuronal loss, Abeta burden and Abeta plaque formation in APP/PS1 mice, but not in WT mice.	Benzo(a)pyrene	10-13	amyloid beta (A4) precursor protein	Mus musculus	47-52
32867800-12	2020	Moreover, BaP exposure promoted neuronal loss, Abeta burden and Abeta plaque formation in APP/PS1 mice, but not in WT mice.	Benzo(a)pyrene	10-13	amyloid beta (A4) precursor protein	Mus musculus	64-69
32867800-12	2020	Moreover, BaP exposure promoted neuronal loss, Abeta burden and Abeta plaque formation in APP/PS1 mice, but not in WT mice.	Benzo(a)pyrene	10-13	presenilin 1	Mus musculus	94-97
32867800-13	2020	Gene expression profiling showed most robust alteration in genes and pathways related to inflammation and immunoregulatory process, Abeta secretion and degradation, and synaptic formation in WT and APP/PS1 mice after BaP exposure.	Benzo(a)pyrene	217-220	amyloid beta (A4) precursor protein	Mus musculus	132-137
32867800-13	2020	Gene expression profiling showed most robust alteration in genes and pathways related to inflammation and immunoregulatory process, Abeta secretion and degradation, and synaptic formation in WT and APP/PS1 mice after BaP exposure.	Benzo(a)pyrene	217-220	presenilin 1	Mus musculus	202-205
32867800-14	2020	Consistently, the cortex and the hippocampus of WT and APP/PS1 mice displayed activation of microglia and astroglia and upregulation of inducible nitric oxide synthase (iNOS), glial fibrillary acidic protein (GFAP), and NADPH oxidase (three widely used neuroinflammatory markers) after BaP exposure.	Benzo(a)pyrene	286-289	presenilin 1	Mus musculus	59-62
32867800-15	2020	Furthermore, BaP exposure aggravated neurodegeneration induced by aged Abeta peptide in primary neuron-glia cultures through enhancing NADPH oxidase-derived oxidative stress.	Benzo(a)pyrene	13-16	amyloid beta (A4) precursor protein	Mus musculus	71-76
32349929-3	2020	Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-111
32681969-0	2020	MicroRNA expression profiling and the role of ALCAM modulating tumor growth and metastasis in benzo[a]pyrene-transformed 16HBE cells.	Benzo(a)pyrene	94-108	activated leukocyte cell adhesion molecule	Homo sapiens	46-51
32681969-8	2020	In conclusion, miR-152-3p/ALCAM, miR-142-5p/ALCAM and miR-211-5p/ALCAM axes may be involved in BaP-induced carcinogenesis.	Benzo(a)pyrene	95-98	microRNA 152	Homo sapiens	15-22
32681969-8	2020	In conclusion, miR-152-3p/ALCAM, miR-142-5p/ALCAM and miR-211-5p/ALCAM axes may be involved in BaP-induced carcinogenesis.	Benzo(a)pyrene	95-98	activated leukocyte cell adhesion molecule	Homo sapiens	26-31
32681969-8	2020	In conclusion, miR-152-3p/ALCAM, miR-142-5p/ALCAM and miR-211-5p/ALCAM axes may be involved in BaP-induced carcinogenesis.	Benzo(a)pyrene	95-98	microRNA 142	Homo sapiens	33-40
32681969-8	2020	In conclusion, miR-152-3p/ALCAM, miR-142-5p/ALCAM and miR-211-5p/ALCAM axes may be involved in BaP-induced carcinogenesis.	Benzo(a)pyrene	95-98	activated leukocyte cell adhesion molecule	Homo sapiens	44-49
32681969-8	2020	In conclusion, miR-152-3p/ALCAM, miR-142-5p/ALCAM and miR-211-5p/ALCAM axes may be involved in BaP-induced carcinogenesis.	Benzo(a)pyrene	95-98	microRNA 211	Homo sapiens	54-61
32681969-8	2020	In conclusion, miR-152-3p/ALCAM, miR-142-5p/ALCAM and miR-211-5p/ALCAM axes may be involved in BaP-induced carcinogenesis.	Benzo(a)pyrene	95-98	activated leukocyte cell adhesion molecule	Homo sapiens	44-49
32553695-4	2020	In BM, CYP1B1-mediated metabolism of 7, 12-dimethylbenz[a]anthracene (DMBA) suppresses HSPC colony formation within 6 h, whereas benzo(a)pyrene (BP) generates protective cytokines.	Benzo(a)pyrene	129-143	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	7-13
32553695-4	2020	In BM, CYP1B1-mediated metabolism of 7, 12-dimethylbenz[a]anthracene (DMBA) suppresses HSPC colony formation within 6 h, whereas benzo(a)pyrene (BP) generates protective cytokines.	Benzo(a)pyrene	145-147	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	7-13
32347385-8	2020	BP also significantly inhibited intrahepatic macrophage activation and intercellular adhesion, improved endothelial damage, and significantly improved endothelin 1-nitric oxide balance and microcirculation perfusion.	Benzo(a)pyrene	0-2	endothelin 1	Rattus norvegicus	151-163
32349929-3	2020	Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
32349929-3	2020	Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells.	Benzo(a)pyrene	16-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-111
32349929-3	2020	Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells.	Benzo(a)pyrene	16-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
32166782-0	2020	Benzo[a]pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	109-134
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	115-129	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
32802178-0	2020	Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis.	Benzo(a)pyrene	70-84	ubiquitin specific peptidase 7	Homo sapiens	15-19
32802178-0	2020	Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis.	Benzo(a)pyrene	70-84	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	29-34
32802178-7	2020	Both loss-of-function and gain-of-function approaches were used to validate the role of MCL-1 in arsenic plus BaP co-exposure-enhanced CSC-like property and tumorigenicity.	Benzo(a)pyrene	110-113	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	88-93
32802178-8	2020	Results: Arsenic plus BaP co-exposure-transformed cells express significantly higher protein levels of MCL-1 than the passage-matched control, arsenic or BaP exposure alone-transformed cells.	Benzo(a)pyrene	22-25	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	103-108
32802178-9	2020	Knocking down MCL-1 levels in arsenic plus BaP co-exposure-transformed cells significantly reduced their apoptosis resistance, CSC-like property and tumorigenicity in mice.	Benzo(a)pyrene	43-46	myeloid cell leukemia sequence 1	Mus musculus	14-19
32802178-10	2020	Mechanistic studies revealed that arsenic plus BaP co-exposure up-regulates MCL-1 protein levels by synergistically activating the PI3K/Akt/mTOR pathway to increase the level of a deubiquitinase USP7, which in turn reduces the level of MCL-1 protein ubiquitination and prevents its subsequent proteasome degradation.	Benzo(a)pyrene	47-50	myeloid cell leukemia sequence 1	Mus musculus	76-81
32802178-10	2020	Mechanistic studies revealed that arsenic plus BaP co-exposure up-regulates MCL-1 protein levels by synergistically activating the PI3K/Akt/mTOR pathway to increase the level of a deubiquitinase USP7, which in turn reduces the level of MCL-1 protein ubiquitination and prevents its subsequent proteasome degradation.	Benzo(a)pyrene	47-50	AKT serine/threonine kinase 1	Homo sapiens	136-139
32802178-10	2020	Mechanistic studies revealed that arsenic plus BaP co-exposure up-regulates MCL-1 protein levels by synergistically activating the PI3K/Akt/mTOR pathway to increase the level of a deubiquitinase USP7, which in turn reduces the level of MCL-1 protein ubiquitination and prevents its subsequent proteasome degradation.	Benzo(a)pyrene	47-50	mechanistic target of rapamycin kinase	Homo sapiens	140-144
32802178-10	2020	Mechanistic studies revealed that arsenic plus BaP co-exposure up-regulates MCL-1 protein levels by synergistically activating the PI3K/Akt/mTOR pathway to increase the level of a deubiquitinase USP7, which in turn reduces the level of MCL-1 protein ubiquitination and prevents its subsequent proteasome degradation.	Benzo(a)pyrene	47-50	ubiquitin specific peptidase 7	Homo sapiens	195-199
32802178-10	2020	Mechanistic studies revealed that arsenic plus BaP co-exposure up-regulates MCL-1 protein levels by synergistically activating the PI3K/Akt/mTOR pathway to increase the level of a deubiquitinase USP7, which in turn reduces the level of MCL-1 protein ubiquitination and prevents its subsequent proteasome degradation.	Benzo(a)pyrene	47-50	myeloid cell leukemia sequence 1	Mus musculus	236-241
32802178-11	2020	Conclusions: The deubiquitinase USP7-mediated MCL-1 up-regulation enhances arsenic and BaP co-exposure-induced CSC-like property and tumorigenesis, providing the first evidence demonstrating that USP7 stabilizes MCL-1 protein during the tumorigenic process.	Benzo(a)pyrene	87-90	ubiquitin specific peptidase 7	Homo sapiens	32-36
32802178-11	2020	Conclusions: The deubiquitinase USP7-mediated MCL-1 up-regulation enhances arsenic and BaP co-exposure-induced CSC-like property and tumorigenesis, providing the first evidence demonstrating that USP7 stabilizes MCL-1 protein during the tumorigenic process.	Benzo(a)pyrene	87-90	myeloid cell leukemia sequence 1	Mus musculus	46-51
32802178-11	2020	Conclusions: The deubiquitinase USP7-mediated MCL-1 up-regulation enhances arsenic and BaP co-exposure-induced CSC-like property and tumorigenesis, providing the first evidence demonstrating that USP7 stabilizes MCL-1 protein during the tumorigenic process.	Benzo(a)pyrene	87-90	ubiquitin specific peptidase 7	Homo sapiens	196-200
32802178-11	2020	Conclusions: The deubiquitinase USP7-mediated MCL-1 up-regulation enhances arsenic and BaP co-exposure-induced CSC-like property and tumorigenesis, providing the first evidence demonstrating that USP7 stabilizes MCL-1 protein during the tumorigenic process.	Benzo(a)pyrene	87-90	myeloid cell leukemia sequence 1	Mus musculus	212-217
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	115-129	aryl hydrocarbon receptor	Homo sapiens	180-205
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	115-129	aryl hydrocarbon receptor	Homo sapiens	207-210
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	115-129	aryl hydrocarbon receptor	Homo sapiens	212-215
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	115-129	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	238-242
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	131-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	131-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	131-136	aryl hydrocarbon receptor	Homo sapiens	180-205
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	131-136	aryl hydrocarbon receptor	Homo sapiens	207-210
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	131-136	aryl hydrocarbon receptor	Homo sapiens	212-215
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	131-136	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	238-242
32409577-1	2020	Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs.	Benzo(a)pyrene	115-129	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
32541975-5	2020	The effects of BaP on the decrease of dopaminergic neurons and increase and aggregation of alpha-synuclein were observed by immunohistochemistry and Western blot experiments respectively, and the expression of related mRNA was detected by quantitative real-time PCR (qRT-PCR).	Benzo(a)pyrene	15-18	synuclein, alpha	Mus musculus	91-106
32229384-8	2020	Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1.	Benzo(a)pyrene	0-14	L1 cell adhesion molecule	Homo sapiens	95-98
32229384-8	2020	Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1.	Benzo(a)pyrene	0-14	L1 cell adhesion molecule	Homo sapiens	110-113
32229384-8	2020	Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1.	Benzo(a)pyrene	0-14	L1 cell adhesion molecule	Homo sapiens	110-113
32229384-8	2020	Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1.	Benzo(a)pyrene	0-14	L1 cell adhesion molecule	Homo sapiens	110-113
32541975-12	2020	CONCLUSION: BaP exposure not only inhibited function of neurotransmitter receptor and dopamine transporter, but also interfered cell autophagy, thereby hindering the degradation of alpha-synuclein, which could lead to decrease of dopaminergic neurons in substantia nigra and increase and aggregation of alpha-synuclein in midbrain, as the significant pathology of Parkinson"s disease.	Benzo(a)pyrene	12-15	synuclein, alpha	Mus musculus	181-196
32541975-12	2020	CONCLUSION: BaP exposure not only inhibited function of neurotransmitter receptor and dopamine transporter, but also interfered cell autophagy, thereby hindering the degradation of alpha-synuclein, which could lead to decrease of dopaminergic neurons in substantia nigra and increase and aggregation of alpha-synuclein in midbrain, as the significant pathology of Parkinson"s disease.	Benzo(a)pyrene	12-15	synuclein, alpha	Mus musculus	303-318
32247962-0	2020	Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver.	Benzo(a)pyrene	19-33	microRNA 34a	Mus musculus	78-85
32115946-5	2020	Also, the action of BaP on elevating COX-2 was initiated by BPDE firmly binding to the active pockets of COX-2, then followed by the production of prostaglandin E2 (PGE2) and upregulation of its EP2 and EP4 receptors, finally stimulating the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway.	Benzo(a)pyrene	20-23	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	195-198
32115946-5	2020	Also, the action of BaP on elevating COX-2 was initiated by BPDE firmly binding to the active pockets of COX-2, then followed by the production of prostaglandin E2 (PGE2) and upregulation of its EP2 and EP4 receptors, finally stimulating the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway.	Benzo(a)pyrene	20-23	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	203-206
32247962-9	2020	The BaP exposure induced severe liver histological injury and markedly enhanced AST, ALT and MDA level.	Benzo(a)pyrene	4-7	glutamic pyruvic transaminase, soluble	Mus musculus	85-88
32247962-13	2020	In summary, melatonin appears to be effective in BaP-induced hepatotoxicity maybe through the miR-34a/Sirt1/autophagy molecular pathway.	Benzo(a)pyrene	49-52	microRNA 34a	Mus musculus	94-101
32247962-13	2020	In summary, melatonin appears to be effective in BaP-induced hepatotoxicity maybe through the miR-34a/Sirt1/autophagy molecular pathway.	Benzo(a)pyrene	49-52	sirtuin 1	Mus musculus	102-107
32247962-0	2020	Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver.	Benzo(a)pyrene	19-33	sirtuin 1	Mus musculus	86-91
32247962-9	2020	The BaP exposure induced severe liver histological injury and markedly enhanced AST, ALT and MDA level.	Benzo(a)pyrene	4-7	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	80-83
32506967-2	2022	Although BaP is one of the most extensively studied pollutants, the underlying mechanisms through which BaP affects reactive oxygen species (ROS)/hypoxia-inducible factor 1alpha (HIF-1alpha)/heme oxygenase 1(HO-1) signaling during lung or breast carcinogenesis are not yet fully understood.	Benzo(a)pyrene	104-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-177
32526964-0	2020	Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.	Benzo(a)pyrene	19-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-78
32526964-0	2020	Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.	Benzo(a)pyrene	19-33	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
32526964-0	2020	Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.	Benzo(a)pyrene	19-33	heme oxygenase 1	Homo sapiens	120-125
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	65-90
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	92-95
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-200
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	202-208
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	65-90
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	92-95
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	16-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-200
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	16-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	202-208
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	261-264	aryl hydrocarbon receptor	Homo sapiens	65-90
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	261-264	aryl hydrocarbon receptor	Homo sapiens	92-95
32526964-1	2020	Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP.	Benzo(a)pyrene	261-264	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-200
32526964-5	2020	BAI and BAI-containing herbal medicine Wogon and Oren-gedoku-to could inhibit the BaP-induced CYP1A1 expression.	Benzo(a)pyrene	82-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-100
32526964-6	2020	In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production.	Benzo(a)pyrene	154-157	NFE2 like bZIP transcription factor 2	Homo sapiens	48-91
32526964-6	2020	In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production.	Benzo(a)pyrene	154-157	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
32526964-6	2020	In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production.	Benzo(a)pyrene	154-157	heme oxygenase 1	Homo sapiens	103-119
32526964-6	2020	In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production.	Benzo(a)pyrene	154-157	heme oxygenase 1	Homo sapiens	121-126
32526964-7	2020	The BaP-induced IL1A and IL1B was also downregulated by BAI.	Benzo(a)pyrene	4-7	interleukin 1 alpha	Homo sapiens	16-20
32526964-7	2020	The BaP-induced IL1A and IL1B was also downregulated by BAI.	Benzo(a)pyrene	4-7	interleukin 1 beta	Homo sapiens	25-29
32526964-9	2020	These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities.	Benzo(a)pyrene	114-117	aryl hydrocarbon receptor	Homo sapiens	127-130
32526964-9	2020	These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities.	Benzo(a)pyrene	114-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	131-137
32526964-9	2020	These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities.	Benzo(a)pyrene	114-117	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
32526964-9	2020	These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities.	Benzo(a)pyrene	114-117	heme oxygenase 1	Homo sapiens	158-163
32506967-7	2022	Moreover, the induction of ROS and the modulation of HIF-1alpha and HO-1 were observed after BaP exposure.	Benzo(a)pyrene	93-96	heme oxygenase 1	Homo sapiens	68-72
32506967-8	2022	Taken together, these findings suggest that BaP affects proliferation with reference to metabolic genes and ROS/HIF-1alpha/HO-1 signaling in A549 and MCF-7 cancer cells.	Benzo(a)pyrene	44-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
32506967-8	2022	Taken together, these findings suggest that BaP affects proliferation with reference to metabolic genes and ROS/HIF-1alpha/HO-1 signaling in A549 and MCF-7 cancer cells.	Benzo(a)pyrene	44-47	heme oxygenase 1	Homo sapiens	123-127
31811747-3	2020	The ligands of AhR such as tetrachlorodibenzo-p-dioxin, benzo[a]pyrene and 3, 3"-diindolylmetheane are able to inhibit osteoclastogenesis and attenuate arthritis in mice.	Benzo(a)pyrene	56-70	aryl-hydrocarbon receptor	Mus musculus	15-18
31748929-3	2020	In this study, to elucidate how AHR mediates inflammation homeostasis, we hypothesized that AHR expression may diminish during long-term exposure to benzo [a] pyrene (B [a]P), a carcinogen in cigarette smoke.	Benzo(a)pyrene	149-165	aryl hydrocarbon receptor	Homo sapiens	32-35
31748929-3	2020	In this study, to elucidate how AHR mediates inflammation homeostasis, we hypothesized that AHR expression may diminish during long-term exposure to benzo [a] pyrene (B [a]P), a carcinogen in cigarette smoke.	Benzo(a)pyrene	149-165	aryl hydrocarbon receptor	Homo sapiens	92-95
32506967-2	2022	Although BaP is one of the most extensively studied pollutants, the underlying mechanisms through which BaP affects reactive oxygen species (ROS)/hypoxia-inducible factor 1alpha (HIF-1alpha)/heme oxygenase 1(HO-1) signaling during lung or breast carcinogenesis are not yet fully understood.	Benzo(a)pyrene	104-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-189
32506967-2	2022	Although BaP is one of the most extensively studied pollutants, the underlying mechanisms through which BaP affects reactive oxygen species (ROS)/hypoxia-inducible factor 1alpha (HIF-1alpha)/heme oxygenase 1(HO-1) signaling during lung or breast carcinogenesis are not yet fully understood.	Benzo(a)pyrene	104-107	heme oxygenase 1	Homo sapiens	191-207
32506967-2	2022	Although BaP is one of the most extensively studied pollutants, the underlying mechanisms through which BaP affects reactive oxygen species (ROS)/hypoxia-inducible factor 1alpha (HIF-1alpha)/heme oxygenase 1(HO-1) signaling during lung or breast carcinogenesis are not yet fully understood.	Benzo(a)pyrene	104-107	heme oxygenase 1	Homo sapiens	208-212
32506967-3	2022	In this study, we analyzed the effects of 0 (control), 1, 5, or 25 microM BaP exposure on A549 and MCF-7 cancer cells, by evaluating cell viability, cell cycle, and regulatory protein expression, metabolic gene expression, and ROS/HIF-1alpha/HO-1 signaling.	Benzo(a)pyrene	74-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	231-241
32506967-3	2022	In this study, we analyzed the effects of 0 (control), 1, 5, or 25 microM BaP exposure on A549 and MCF-7 cancer cells, by evaluating cell viability, cell cycle, and regulatory protein expression, metabolic gene expression, and ROS/HIF-1alpha/HO-1 signaling.	Benzo(a)pyrene	74-77	heme oxygenase 1	Homo sapiens	242-246
32506967-5	2022	BaP significantly increased the proportions of cells in S and G2/M phases, with concomitant reductions in the proportions of cells in G0/G1 phase, following 5 and 25 microM exposure, which was accompanied by the upregulation of the regulatory proteins cyclin A, cyclin B, cyclin-dependent kinase (CDK)1, and CDK2.	Benzo(a)pyrene	0-3	cyclin A2	Homo sapiens	252-260
32506967-5	2022	BaP significantly increased the proportions of cells in S and G2/M phases, with concomitant reductions in the proportions of cells in G0/G1 phase, following 5 and 25 microM exposure, which was accompanied by the upregulation of the regulatory proteins cyclin A, cyclin B, cyclin-dependent kinase (CDK)1, and CDK2.	Benzo(a)pyrene	0-3	cyclin dependent kinase 1	Homo sapiens	272-302
32506967-5	2022	BaP significantly increased the proportions of cells in S and G2/M phases, with concomitant reductions in the proportions of cells in G0/G1 phase, following 5 and 25 microM exposure, which was accompanied by the upregulation of the regulatory proteins cyclin A, cyclin B, cyclin-dependent kinase (CDK)1, and CDK2.	Benzo(a)pyrene	0-3	cyclin dependent kinase 2	Homo sapiens	308-312
32506967-7	2022	Moreover, the induction of ROS and the modulation of HIF-1alpha and HO-1 were observed after BaP exposure.	Benzo(a)pyrene	93-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
32092627-7	2020	We show that for some PAH congeners, for example, benzo[a]pyrene (BaP)-the forest-fire-induced air emissions are almost one order of magnitude higher than previous emission inventories in the Arctic.	Benzo(a)pyrene	50-64	phenylalanine hydroxylase	Homo sapiens	22-25
32092627-7	2020	We show that for some PAH congeners, for example, benzo[a]pyrene (BaP)-the forest-fire-induced air emissions are almost one order of magnitude higher than previous emission inventories in the Arctic.	Benzo(a)pyrene	66-69	phenylalanine hydroxylase	Homo sapiens	22-25
32220751-0	2020	Resveratrol prevents benzo(a)pyrene-induced disruption of mitochondrial homeostasis via the AMPK signaling pathway in primary cultured neurons.	Benzo(a)pyrene	21-35	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	92-96
32220751-8	2020	This work provided insights into the role of RSV in preventing BaP-induced primary neuronal apoptosis in the mitochondrial pathway, mainly via regulation of mitochondrial biogenesis and mitophagy through AMPK pathway, thus maintaining the integrity of the mitochondrial network.	Benzo(a)pyrene	63-66	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	204-208
30472931-2	2020	In this paper, we propose a new combined neural network algorithm which based on Elman, echo state network (ESN) and cascaded BP neural network (CBP) to predict PM10 and PM2.5.	Benzo(a)pyrene	126-128	CREB binding protein	Homo sapiens	145-148
32062438-0	2020	Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression.	Benzo(a)pyrene	12-26	suppressor of cytokine signaling 3	Mus musculus	155-160
32670863-0	2020	Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay.	Benzo(a)pyrene	76-90	aryl hydrocarbon receptor	Homo sapiens	152-155
32670863-0	2020	Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay.	Benzo(a)pyrene	76-90	G protein-coupled estrogen receptor 1	Homo sapiens	156-161
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	Benzo(a)pyrene	210-215	aryl hydrocarbon receptor	Homo sapiens	90-115
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	Benzo(a)pyrene	210-215	aryl hydrocarbon receptor	Homo sapiens	117-120
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	Benzo(a)pyrene	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	130-159
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	Benzo(a)pyrene	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	161-166
32670863-8	2020	Finally, the study identified targeting AhR and/or GPR30 with specific antagonists as a strategy capable of inhibiting carcinogenesis associated with chronic exposure to low doses of B[a]P and BPA in MCF10AT1 cells.	Benzo(a)pyrene	183-188	aryl hydrocarbon receptor	Homo sapiens	40-43
32670863-8	2020	Finally, the study identified targeting AhR and/or GPR30 with specific antagonists as a strategy capable of inhibiting carcinogenesis associated with chronic exposure to low doses of B[a]P and BPA in MCF10AT1 cells.	Benzo(a)pyrene	183-188	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
32608839-7	2020	As a toxic PAH monomer, the concentration of benzo[a] pyrene ranged from 0 to 11.08 ng L-1.	Benzo(a)pyrene	45-60	L1 cell adhesion molecule	Homo sapiens	87-90
32608839-8	2020	According to "Water Quality Standards for Drinking Water Sources (CJ 3020-1993)" of China, the concentration of benzo[a] pyrene in a water sample (S12) located near Wuxi City exceeded the limit of drinking water standards (10 ng L-1).	Benzo(a)pyrene	112-127	L1 cell adhesion molecule	Homo sapiens	229-232
32588828-0	2020	[Effect of benzo(a)pyrene on the expression of AhR-regulated microRNA in female and male rat lungs].	Benzo(a)pyrene	11-25	aryl hydrocarbon receptor	Rattus norvegicus	47-50
32588828-10	2020	Thus, our results suggest that sex-dependent epigenetic effects of BP may be based on different expression of AhR- and ER- regulated miRNAs.	Benzo(a)pyrene	67-69	aryl hydrocarbon receptor	Rattus norvegicus	110-113
32112355-6	2020	Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio.	Benzo(a)pyrene	27-41	aryl hydrocarbon receptor	Rattus norvegicus	15-18
32112355-6	2020	Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio.	Benzo(a)pyrene	27-41	hepatitis A virus cellular receptor 1	Rattus norvegicus	121-125
32522345-11	2020	In summary, our data suggest that EOM, and partly BaP, reduce lipid peroxidation by a mechanism that involves AhR-dependent inhibition of PTGS-2 expression.	Benzo(a)pyrene	50-53	aryl hydrocarbon receptor	Homo sapiens	110-113
32522345-11	2020	In summary, our data suggest that EOM, and partly BaP, reduce lipid peroxidation by a mechanism that involves AhR-dependent inhibition of PTGS-2 expression.	Benzo(a)pyrene	50-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-144
29099324-1	2020	Vascular resistance is a major determinant of BP and is controlled, in large part, by RhoA-dependent smooth muscle cell (SMC) contraction within small peripheral arterioles and previous studies from our lab indicate that GRAF3 is a critical regulator of RhoA in vascular SMC.	Benzo(a)pyrene	46-48	Rho GTPase activating protein 42	Homo sapiens	221-226
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	Benzo(a)pyrene	46-49	aryl-hydrocarbon receptor	Mus musculus	165-190
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	Benzo(a)pyrene	46-49	aryl-hydrocarbon receptor	Mus musculus	192-195
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	Benzo(a)pyrene	46-49	suppressor of variegation 3-9 1	Mus musculus	270-277
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	Benzo(a)pyrene	46-49	suppressor of cytokine signaling 3	Mus musculus	410-415
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	Benzo(a)pyrene	46-49	thymoma viral proto-oncogene 1	Mus musculus	450-453
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	Benzo(a)pyrene	46-49	mitogen-activated protein kinase 3	Mus musculus	458-464
32086277-9	2020	Accordingly, the alpha2A-adrenoceptor-knockout mice exhibited a systolic BP increase, which was about 40 mm Hg higher than that found in wild-type mice, and more extensive kidney damage.	Benzo(a)pyrene	73-75	adrenergic receptor, alpha 2a	Mus musculus	17-37
32057901-9	2020	In addition, Arl4c expression was downregulated via inhibition of the AKT pathway in A549 and 95-D cells, whereas exposure to benzo (a) pyrene (a carcinogen in smoke) increased Arl4c expression in 16HBE cells via AKT activation.	Benzo(a)pyrene	126-131	ADP ribosylation factor like GTPase 4C	Homo sapiens	177-182
32057901-9	2020	In addition, Arl4c expression was downregulated via inhibition of the AKT pathway in A549 and 95-D cells, whereas exposure to benzo (a) pyrene (a carcinogen in smoke) increased Arl4c expression in 16HBE cells via AKT activation.	Benzo(a)pyrene	126-131	AKT serine/threonine kinase 1	Homo sapiens	213-216
32191207-3	2020	We show that Sox9 is expressed in human and ferret BPs and is required for BP proliferation in embryonic ferret neocortex.	Benzo(a)pyrene	51-53	SRY-box transcription factor 9	Homo sapiens	13-17
32023792-10	2020	BaP significantly decreased the angiogenesis factor (VEGFR, Ang-1 and Tie2) and increased the anti-angiogenic factor THBS1.	Benzo(a)pyrene	0-3	angiopoietin 1	Rattus norvegicus	60-65
32023792-10	2020	BaP significantly decreased the angiogenesis factor (VEGFR, Ang-1 and Tie2) and increased the anti-angiogenic factor THBS1.	Benzo(a)pyrene	0-3	TEK receptor tyrosine kinase	Rattus norvegicus	70-74
32023792-10	2020	BaP significantly decreased the angiogenesis factor (VEGFR, Ang-1 and Tie2) and increased the anti-angiogenic factor THBS1.	Benzo(a)pyrene	0-3	thrombospondin 1	Rattus norvegicus	117-122
32023792-11	2020	Inhibited THBS1 function by LSKL partially rescued the angiogenesis defect caused by BaP.	Benzo(a)pyrene	85-88	thrombospondin 1	Rattus norvegicus	10-15
32023792-13	2020	Furthermore, Notch signaling molecules, including Notch1, Dll4, Jag1 and Hey2, which are essential for the establishment and maturation of vascular networks, were affected by BaP exposure.	Benzo(a)pyrene	175-178	notch receptor 1	Rattus norvegicus	13-18
32023792-13	2020	Furthermore, Notch signaling molecules, including Notch1, Dll4, Jag1 and Hey2, which are essential for the establishment and maturation of vascular networks, were affected by BaP exposure.	Benzo(a)pyrene	175-178	notch receptor 1	Rattus norvegicus	50-56
32023792-13	2020	Furthermore, Notch signaling molecules, including Notch1, Dll4, Jag1 and Hey2, which are essential for the establishment and maturation of vascular networks, were affected by BaP exposure.	Benzo(a)pyrene	175-178	delta like canonical Notch ligand 4	Rattus norvegicus	58-62
32023792-13	2020	Furthermore, Notch signaling molecules, including Notch1, Dll4, Jag1 and Hey2, which are essential for the establishment and maturation of vascular networks, were affected by BaP exposure.	Benzo(a)pyrene	175-178	jagged canonical Notch ligand 1	Rattus norvegicus	64-68
32023792-13	2020	Furthermore, Notch signaling molecules, including Notch1, Dll4, Jag1 and Hey2, which are essential for the establishment and maturation of vascular networks, were affected by BaP exposure.	Benzo(a)pyrene	175-178	hes-related family bHLH transcription factor with YRPW motif 2	Rattus norvegicus	73-77
32265041-1	2020	Diet is a major source of human exposure to polycyclic aromatic hydrocarbons (PAHs), of which benzo[a]pyrene (BaP) is the most commonly studied and measured.	Benzo(a)pyrene	94-108	prohibitin 2	Homo sapiens	110-113
32191207-4	2020	Conditional Sox9 expression in the mouse BP lineage, where it normally is not expressed, increases BP proliferation, reduces Tbr2 levels and induces Olig2 expression, indicative of premature gliogenesis.	Benzo(a)pyrene	41-43	SRY (sex determining region Y)-box 9	Mus musculus	12-16
32191207-4	2020	Conditional Sox9 expression in the mouse BP lineage, where it normally is not expressed, increases BP proliferation, reduces Tbr2 levels and induces Olig2 expression, indicative of premature gliogenesis.	Benzo(a)pyrene	41-43	eomesodermin	Mus musculus	125-129
32191207-4	2020	Conditional Sox9 expression in the mouse BP lineage, where it normally is not expressed, increases BP proliferation, reduces Tbr2 levels and induces Olig2 expression, indicative of premature gliogenesis.	Benzo(a)pyrene	41-43	oligodendrocyte transcription factor 2	Mus musculus	149-154
32191207-5	2020	Conditional Sox9 expression also results in cell-non-autonomous stimulation of BP proliferation followed by increased upper-layer neuron production.	Benzo(a)pyrene	79-81	SRY (sex determining region Y)-box 9	Mus musculus	12-16
32046055-11	2020	Moreover, the levels of tunnel staining and p53 expression were significantly increased by BaP, whereas these changes were noticeably modulated after curcumin treatment.	Benzo(a)pyrene	91-94	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	44-47
31992575-3	2020	Transgenic mice with one-half Klotho deficiency displayed a spontaneous BP increase and salt-sensitive hypertension in response to high sodium intake.	Benzo(a)pyrene	72-74	klotho	Mus musculus	30-36
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Benzo(a)pyrene	22-25	tumor necrosis factor	Rattus norvegicus	123-132
32111491-5	2020	We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin.	Benzo(a)pyrene	168-182	brain derived neurotrophic factor	Homo sapiens	61-65
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Benzo(a)pyrene	22-25	interleukin 6	Rattus norvegicus	135-148
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Benzo(a)pyrene	22-25	interleukin 6	Rattus norvegicus	150-154
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Benzo(a)pyrene	22-25	C-reactive protein	Rattus norvegicus	161-179
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Benzo(a)pyrene	22-25	C-reactive protein	Rattus norvegicus	181-184
32111491-5	2020	We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin.	Benzo(a)pyrene	168-182	brain derived neurotrophic factor	Homo sapiens	67-100
32111491-5	2020	We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin.	Benzo(a)pyrene	184-186	brain derived neurotrophic factor	Homo sapiens	61-65
32111491-5	2020	We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin.	Benzo(a)pyrene	184-186	brain derived neurotrophic factor	Homo sapiens	67-100
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	Benzo(a)pyrene	46-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-127
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	Benzo(a)pyrene	46-60	sulfotransferase family 1A member 1	Homo sapiens	128-136
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	Benzo(a)pyrene	46-60	sulfotransferase family 1A member 1	Homo sapiens	142-150
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	Benzo(a)pyrene	46-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	156-163
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	Benzo(a)pyrene	46-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	173-180
31112310-9	2020	Benzo[a]pyrene induced micronuclei in V79-Mz communicating with V79-hCYP1A1 via porous membranes, whereas aflatoxin B1 was inactive in V79-Mz communicating with V79-hCYP1A2.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	68-75
31112310-9	2020	Benzo[a]pyrene induced micronuclei in V79-Mz communicating with V79-hCYP1A1 via porous membranes, whereas aflatoxin B1 was inactive in V79-Mz communicating with V79-hCYP1A2.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	165-172
31135098-6	2020	We also assessed the production of inflammatory factors interleukin-8 and chemokine ligand-2 induced by benzo(a)pyrene exposure at both mRNA and protein levels.	Benzo(a)pyrene	104-118	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
31689476-1	2020	Atrazine (ATZ), a widely used agricultural pesticide and benzo[a]pyrene (BaP), a ubiquitous environmental human carcinogen can induce alterations of spermatogenesis.	Benzo(a)pyrene	57-71	prohibitin 2	Homo sapiens	73-76
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	26-40	aryl hydrocarbon receptor	Homo sapiens	79-82
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	26-40	aryl hydrocarbon receptor	Homo sapiens	96-99
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	166-185
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	187-193
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	42-45	aryl hydrocarbon receptor	Homo sapiens	79-82
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	42-45	aryl hydrocarbon receptor	Homo sapiens	96-99
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	42-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	166-185
31730885-5	2020	In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation.	Benzo(a)pyrene	42-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	187-193
31730885-6	2020	BaP induces CYP1A1 expression through AhR signaling and inhibits the protective effect of 17beta-estradiol (E2) on hepatic steatosis, characterized by triglyceride accumulation, and markers of liver damage are significantly elevated.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-18
31730885-6	2020	BaP induces CYP1A1 expression through AhR signaling and inhibits the protective effect of 17beta-estradiol (E2) on hepatic steatosis, characterized by triglyceride accumulation, and markers of liver damage are significantly elevated.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	38-41
32065759-3	2020	It is well-known that Nrf2 is associated increase of antioxidant enzyme catalase (CAT) or detoxification enzyme glutathione S-transferase (GST) in HaCat cells treated with B[a]P under optimal condition of hyperoxia (40% oxygenation) conditions.	Benzo(a)pyrene	172-177	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
32065759-3	2020	It is well-known that Nrf2 is associated increase of antioxidant enzyme catalase (CAT) or detoxification enzyme glutathione S-transferase (GST) in HaCat cells treated with B[a]P under optimal condition of hyperoxia (40% oxygenation) conditions.	Benzo(a)pyrene	172-177	catalase	Homo sapiens	72-80
32065759-3	2020	It is well-known that Nrf2 is associated increase of antioxidant enzyme catalase (CAT) or detoxification enzyme glutathione S-transferase (GST) in HaCat cells treated with B[a]P under optimal condition of hyperoxia (40% oxygenation) conditions.	Benzo(a)pyrene	172-177	catalase	Homo sapiens	82-85
32065759-3	2020	It is well-known that Nrf2 is associated increase of antioxidant enzyme catalase (CAT) or detoxification enzyme glutathione S-transferase (GST) in HaCat cells treated with B[a]P under optimal condition of hyperoxia (40% oxygenation) conditions.	Benzo(a)pyrene	172-177	glutathione S-transferase kappa 1	Homo sapiens	112-137
32065759-3	2020	It is well-known that Nrf2 is associated increase of antioxidant enzyme catalase (CAT) or detoxification enzyme glutathione S-transferase (GST) in HaCat cells treated with B[a]P under optimal condition of hyperoxia (40% oxygenation) conditions.	Benzo(a)pyrene	172-177	glutathione S-transferase kappa 1	Homo sapiens	139-142
32065759-9	2020	Data suggest that optimal hyperoxia exposure of 40% oxygenation may reduce cellular toxicity induced by B[a]P in HaCat cells as evidenced by inhibition of DNA damage, free radical generation, and down-regulation of Nrf2.	Benzo(a)pyrene	104-109	NFE2 like bZIP transcription factor 2	Homo sapiens	215-219
31612222-0	2019	Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells.	Benzo(a)pyrene	91-105	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	12-27
31655123-1	2020	Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene.	Benzo(a)pyrene	173-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-18
31655123-1	2020	Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene.	Benzo(a)pyrene	173-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-26
31168938-8	2020	The %hIGR was significantly higher (44% vs 56%, P &lt; 0.001), and the frequency of BG &gt;240 mg/dL and BG &lt;70 mg/dL was significantly lower in the BP + DU group than in the BP group (both P &lt; 0.001).	Benzo(a)pyrene	152-154	nectin cell adhesion molecule 1	Homo sapiens	5-9
31693254-12	2020	Furthermore, bFGF was observed to be effectively loaded onto and released from the porous BP scaffolds.	Benzo(a)pyrene	90-92	fibroblast growth factor 2	Rattus norvegicus	13-17
31612222-6	2019	In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	177-180	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	13-16
31612222-6	2019	In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	177-180	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	13-16
31612222-7	2019	As was seen in the HRN mouse model, these results suggest that Cyb5 contributes to the bioactivation of BaP in POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	104-107	cytochrome b5 type A (microsomal)	Mus musculus	63-67
31612222-1	2019	The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes.	Benzo(a)pyrene	29-43	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	123-138
31612222-7	2019	As was seen in the HRN mouse model, these results suggest that Cyb5 contributes to the bioactivation of BaP in POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	104-107	cytochrome p450 oxidoreductase	Mus musculus	111-114
31612222-8	2019	These results indicate that CYP enzymes may play a more important role in the detoxication of BaP, as opposed to its bioactivation.	Benzo(a)pyrene	94-97	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	28-31
31612222-1	2019	The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes.	Benzo(a)pyrene	29-43	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	140-143
31612222-1	2019	The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes.	Benzo(a)pyrene	45-48	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	123-138
31612222-1	2019	The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes.	Benzo(a)pyrene	45-48	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	140-143
31612222-2	2019	However, studies using the Hepatic Reductase Null (HRN) mouse model, in which cytochrome P450 oxidoreductase (POR), the electron donor to CYP enzymes, is deleted specifically in hepatocytes, have shown that loss of hepatic POR-mediated CYP function leads to greater BaP-DNA adduct formation in livers of these mice than in wild-type (WT) mice.	Benzo(a)pyrene	266-269	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	78-93
31612222-2	2019	However, studies using the Hepatic Reductase Null (HRN) mouse model, in which cytochrome P450 oxidoreductase (POR), the electron donor to CYP enzymes, is deleted specifically in hepatocytes, have shown that loss of hepatic POR-mediated CYP function leads to greater BaP-DNA adduct formation in livers of these mice than in wild-type (WT) mice.	Benzo(a)pyrene	266-269	cytochrome p450 oxidoreductase	Mus musculus	110-113
31612222-6	2019	In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	27-30	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	13-16
31612222-6	2019	In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	27-30	cytochrome p450 oxidoreductase	Mus musculus	73-76
31612222-6	2019	In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	27-30	cytochrome p450 oxidoreductase	Mus musculus	257-260
31612222-6	2019	In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells.	Benzo(a)pyrene	177-180	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	13-16
31817720-9	2019	Our results showed that TIPE2 was involved in nicotine-, nicotine-derived nitrosamine ketone (NNK)-, N-nitrosonornicotine (NNN)-, and benzo[a]pyrene (BaP)-mediated lung cancer through inhibited proliferation, survival, and migration via modulation of nuclear factor kappa B (NF-kappaB)- and NF-kappaB-regulated gene products, which are involved in the regulation of diverse processes in lung cancer cells.	Benzo(a)pyrene	134-148	TNF alpha induced protein 8 like 2	Homo sapiens	24-29
31561077-8	2019	The expression of NLRP3, NLRP6 and IL-18 protein in the lung tissues of mice exposed to B(a)p plus LPS was upregulated significantly compared with those in Vehicle control group.	Benzo(a)pyrene	88-93	NLR family, pyrin domain containing 3	Mus musculus	18-23
31561077-8	2019	The expression of NLRP3, NLRP6 and IL-18 protein in the lung tissues of mice exposed to B(a)p plus LPS was upregulated significantly compared with those in Vehicle control group.	Benzo(a)pyrene	88-93	NLR family, pyrin domain containing 6	Mus musculus	25-30
31561077-8	2019	The expression of NLRP3, NLRP6 and IL-18 protein in the lung tissues of mice exposed to B(a)p plus LPS was upregulated significantly compared with those in Vehicle control group.	Benzo(a)pyrene	88-93	interleukin 18	Mus musculus	35-40
31561077-11	2019	In conclusion, our results from this study demonstrate that NLRP3 inflammasome, not NLRP6 inflammasome, activation is involved in B(a)p plus LPS-induced inflammation-related lung tumorigenesis in mice, but the mechanisms of NLRP6 participate in the development of lung cancer should be further investigated.	Benzo(a)pyrene	130-135	NLR family, pyrin domain containing 3	Mus musculus	60-65
31823816-6	2019	RESULTS: BDNF, LXA4 and AA, EPA and DHA protected (P &lt; 0.001 and P &lt; 0.01 respectively) against AL/STZ/DB/BP-induced toxicity to RIN5F cells in vitro.	Benzo(a)pyrene	112-114	brain derived neurotrophic factor	Mus musculus	9-13
31823816-7	2019	AL/ STZ/DB/BP inhibited BDNF and LXA4 production by RIN5F cells and were restored to normal by AA, EPA and DHA.	Benzo(a)pyrene	11-13	brain derived neurotrophic factor	Mus musculus	24-28
31823816-8	2019	Sub-optimal doses of BDNF, LXA4, AA and EPA when used in combination protected against cytotoxic action of AL/STZ/DB/BP on RIN5F cells in vitro by restoring LXA4/BDNF levels and altered antioxidant/lipid peroxides/NO levels (P &lt; 0.01) to normal.	Benzo(a)pyrene	117-119	brain derived neurotrophic factor	Mus musculus	21-25
31823816-10	2019	DISCUSSION: AL/STZ/DB/BP-induced cytotoxicity to RIN5F cells in vitro can be prevented by BDNF, LXA4 and AA.	Benzo(a)pyrene	22-24	brain derived neurotrophic factor	Mus musculus	90-94
31823816-11	2019	AL/STZ/DB/BP are cytotoxic, possibly, by suppressing the production of LXA4 and BDNF in RIN5F cells.	Benzo(a)pyrene	10-12	brain derived neurotrophic factor	Mus musculus	80-84
31817720-9	2019	Our results showed that TIPE2 was involved in nicotine-, nicotine-derived nitrosamine ketone (NNK)-, N-nitrosonornicotine (NNN)-, and benzo[a]pyrene (BaP)-mediated lung cancer through inhibited proliferation, survival, and migration via modulation of nuclear factor kappa B (NF-kappaB)- and NF-kappaB-regulated gene products, which are involved in the regulation of diverse processes in lung cancer cells.	Benzo(a)pyrene	150-153	TNF alpha induced protein 8 like 2	Homo sapiens	24-29
31376700-0	2019	Synaptic dopamine release is positively regulated by SNAP-25 that involves in benzo[a]pyrene-induced neurotoxicity.	Benzo(a)pyrene	78-92	synaptosome associated protein 25	Rattus norvegicus	53-60
31707611-0	2019	Involvement of p38 MAPK pathway in benzo(a)pyrene-induced human hepatoma cell migration and invasion.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 14	Homo sapiens	15-18
31707611-1	2019	The objective of this study was to investigate the potential role of p38 mitogen-activated protein kinases (MAPK) in benzo(a)pyrene (BaP)-induced hepatoma cell migration and invasion.	Benzo(a)pyrene	117-131	mitogen-activated protein kinase 14	Homo sapiens	69-72
31707611-1	2019	The objective of this study was to investigate the potential role of p38 mitogen-activated protein kinases (MAPK) in benzo(a)pyrene (BaP)-induced hepatoma cell migration and invasion.	Benzo(a)pyrene	133-136	mitogen-activated protein kinase 14	Homo sapiens	69-72
31707611-5	2019	Our data showed that BaP exposure increased the expression of p-p38 protein in human hepatoma HepG2 cells.	Benzo(a)pyrene	21-24	mitogen-activated protein kinase 14	Homo sapiens	64-67
31707611-6	2019	Exposure to BaP facilitated HepG2 cell migration and invasion, which could be blocked by p38 MAPK inhibitors.	Benzo(a)pyrene	12-15	mitogen-activated protein kinase 14	Homo sapiens	89-92
31707611-7	2019	In addition, BaP exposure induced upregulation of MMP9 mRNA expression, which was modulated by p-p38.	Benzo(a)pyrene	13-16	matrix metallopeptidase 9	Homo sapiens	50-54
31707611-7	2019	In addition, BaP exposure induced upregulation of MMP9 mRNA expression, which was modulated by p-p38.	Benzo(a)pyrene	13-16	mitogen-activated protein kinase 14	Homo sapiens	97-100
31707611-8	2019	In conclusion, p38 MAPK pathway was involved in BaP-induced hepatoma cell migration and invasion.	Benzo(a)pyrene	48-51	mitogen-activated protein kinase 14	Homo sapiens	15-18
31323583-7	2019	We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control.	Benzo(a)pyrene	64-67	interleukin 6	Homo sapiens	117-121
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	nitric oxide synthase 2, inducible	Mus musculus	152-183
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	nitric oxide synthase 2, inducible	Mus musculus	185-189
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	prostaglandin-endoperoxide synthase 2	Mus musculus	192-208
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	prostaglandin-endoperoxide synthase 2	Mus musculus	210-215
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	interleukin 1 beta	Mus musculus	287-312
31699670-5	2019	On the other hand, when BaP-treated BV2 cells were further incubated with FA (10, 20, 40, or 80 mg/mL) for another 24 h, a significant reduction in BaP-induced DNA damage and the release of multiple pro-inflammatory and cytotoxic factors (including interleukin-1beta, interleukin-6, NO, and ROS) was observed in a dose-dependent manner.	Benzo(a)pyrene	24-27	interleukin 1 beta	Mus musculus	249-266
31699670-5	2019	On the other hand, when BaP-treated BV2 cells were further incubated with FA (10, 20, 40, or 80 mg/mL) for another 24 h, a significant reduction in BaP-induced DNA damage and the release of multiple pro-inflammatory and cytotoxic factors (including interleukin-1beta, interleukin-6, NO, and ROS) was observed in a dose-dependent manner.	Benzo(a)pyrene	24-27	interleukin 6	Mus musculus	268-281
31323583-7	2019	We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control.	Benzo(a)pyrene	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
31698770-8	2019	The expression levels of cytochrome P450 (CYP) 1A1 and CYP1B1 were significantly increased in the liver of rats treated with BaP.	Benzo(a)pyrene	125-128	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-50
31394372-0	2019	Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio).	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor 1a	Danio rerio	72-75
31698770-8	2019	The expression levels of cytochrome P450 (CYP) 1A1 and CYP1B1 were significantly increased in the liver of rats treated with BaP.	Benzo(a)pyrene	125-128	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	55-61
31698770-9	2019	However, co-administration of curcumin (200 mg/kg) with BaP markedly reduced CYP1A1 expression in a dose-dependent manner.	Benzo(a)pyrene	56-59	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	77-83
31318498-2	2019	PM2.5 were heated at temperatures of 120, 250, and 360 C. The results demonstrated microbial substances such as LPS and b-glucan, and chemicals including BaP, 1,2-NQ, and 9,10-PQ were reduced drastically in PM2.5 heated at 120 C. On the other hand, DBA, 7,12-BAQ, and BaP-1,6-Q were not noticeably reduced.	Benzo(a)pyrene	154-157	Brca1 associated protein 1	Mus musculus	268-273
31885779-7	2019	CAE inhibited aryl hydrocarbon receptor (AhR) signaling by decreasing both XRE reporter activity and expression of cytochrome P450 1A1 (CYP1A1) induced by B[a]P treatment in HaCaT cells.	Benzo(a)pyrene	155-160	aryl hydrocarbon receptor	Homo sapiens	14-39
31885779-7	2019	CAE inhibited aryl hydrocarbon receptor (AhR) signaling by decreasing both XRE reporter activity and expression of cytochrome P450 1A1 (CYP1A1) induced by B[a]P treatment in HaCaT cells.	Benzo(a)pyrene	155-160	aryl hydrocarbon receptor	Homo sapiens	41-44
31885779-7	2019	CAE inhibited aryl hydrocarbon receptor (AhR) signaling by decreasing both XRE reporter activity and expression of cytochrome P450 1A1 (CYP1A1) induced by B[a]P treatment in HaCaT cells.	Benzo(a)pyrene	155-160	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	115-134
31885779-7	2019	CAE inhibited aryl hydrocarbon receptor (AhR) signaling by decreasing both XRE reporter activity and expression of cytochrome P450 1A1 (CYP1A1) induced by B[a]P treatment in HaCaT cells.	Benzo(a)pyrene	155-160	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	136-142
31271984-3	2019	Female Silurana (Xenopus) tropicalis exposed to a mixture of benzo[a]pyrene and triclosan (50 ng L-1 each) from the tadpole stage developed liver steatosis and transcriptomic signature associated with glucose intolerance syndrome, and pancreatic insulin hyper secretion typical of pre-diabetes.	Benzo(a)pyrene	61-75	ribosomal protein L4	Xenopus tropicalis	97-100
31187406-7	2019	In both rabbit breeds, BP at a dose of 350 mg/kg increased the concentrations of insulin-like growth factor-1 (302.62 ng/ml, P < 0.001), insulin (16.63 ng/ml, P = 0.050), and triiodothyronine (158.50 ng/dl, P < 0.001) in plasma compared with other groups.	Benzo(a)pyrene	23-25	insulin-like growth factor I	Oryctolagus cuniculus	81-109
31187406-7	2019	In both rabbit breeds, BP at a dose of 350 mg/kg increased the concentrations of insulin-like growth factor-1 (302.62 ng/ml, P < 0.001), insulin (16.63 ng/ml, P = 0.050), and triiodothyronine (158.50 ng/dl, P < 0.001) in plasma compared with other groups.	Benzo(a)pyrene	23-25	insulin	Oryctolagus cuniculus	81-88
31660294-9	2019	The results revealed that the oral administration of benzo(a)pyrene resulted in increases in relative lung weight, serum levels of tumor markers (ADA, AHH, and LDH), and the inflammatory marker NF-kappaB, and a decreased total antioxidant capacity compared with the control.	Benzo(a)pyrene	53-67	aryl-hydrocarbon receptor	Mus musculus	151-154
31660294-11	2019	Moreover, benzo(a)pyrene administration induced the upregulation of PKCalpha, COX-2, and Bcl-2 expression, with the downregulation of BAX and caspase-3 expression.	Benzo(a)pyrene	10-24	protein kinase C, alpha	Mus musculus	68-76
31660294-11	2019	Moreover, benzo(a)pyrene administration induced the upregulation of PKCalpha, COX-2, and Bcl-2 expression, with the downregulation of BAX and caspase-3 expression.	Benzo(a)pyrene	10-24	cytochrome c oxidase II, mitochondrial	Mus musculus	78-83
31660294-11	2019	Moreover, benzo(a)pyrene administration induced the upregulation of PKCalpha, COX-2, and Bcl-2 expression, with the downregulation of BAX and caspase-3 expression.	Benzo(a)pyrene	10-24	B cell leukemia/lymphoma 2	Mus musculus	89-94
31660294-11	2019	Moreover, benzo(a)pyrene administration induced the upregulation of PKCalpha, COX-2, and Bcl-2 expression, with the downregulation of BAX and caspase-3 expression.	Benzo(a)pyrene	10-24	BCL2-associated X protein	Mus musculus	134-137
31660294-11	2019	Moreover, benzo(a)pyrene administration induced the upregulation of PKCalpha, COX-2, and Bcl-2 expression, with the downregulation of BAX and caspase-3 expression.	Benzo(a)pyrene	10-24	caspase 3	Mus musculus	142-151
31476125-7	2019	Further, there is intricate competition between the binding of negatively charged HP1 C-terminal extension and solvent anions near the +-2 hydrophobic pockets, which is also influenced by the BP sequence.	Benzo(a)pyrene	192-194	chromobox 5	Homo sapiens	82-85
31515600-5	2019	The objective of this work was to investigate the molecular toxicology and local activation of BaP and PhIP in the presence of IL-6.	Benzo(a)pyrene	95-98	interleukin 6	Homo sapiens	127-131
31515600-10	2019	Compared to BaP or PhIP treatment alone, IL-6 plus BaP or PhIP selectively induced CYP1B1 significantly in both cell lines.	Benzo(a)pyrene	51-54	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	83-89
31515600-12	2019	These data show that BaP- and PhIP-induced DNA damage in mammary cells is potentiated by the inflammatory cytokine IL-6 and that inflammation-induced CYP expression, specifically CYP1B1 via miR27b, is responsible for this effect.	Benzo(a)pyrene	21-24	interleukin 6	Homo sapiens	115-119
31515600-12	2019	These data show that BaP- and PhIP-induced DNA damage in mammary cells is potentiated by the inflammatory cytokine IL-6 and that inflammation-induced CYP expression, specifically CYP1B1 via miR27b, is responsible for this effect.	Benzo(a)pyrene	21-24	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	179-185
31515600-12	2019	These data show that BaP- and PhIP-induced DNA damage in mammary cells is potentiated by the inflammatory cytokine IL-6 and that inflammation-induced CYP expression, specifically CYP1B1 via miR27b, is responsible for this effect.	Benzo(a)pyrene	21-24	microRNA 27b	Homo sapiens	190-196
31694515-1	2019	Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters.	Benzo(a)pyrene	52-66	aryl hydrocarbon receptor	Rattus norvegicus	101-126
31694515-1	2019	Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters.	Benzo(a)pyrene	52-66	aryl hydrocarbon receptor	Rattus norvegicus	128-131
31694515-1	2019	Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters.	Benzo(a)pyrene	68-70	aryl hydrocarbon receptor	Rattus norvegicus	101-126
31694515-1	2019	Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters.	Benzo(a)pyrene	68-70	aryl hydrocarbon receptor	Rattus norvegicus	128-131
31694515-2	2019	The effect of BP on the expression of the oncogenic miR-483-3p, its host gene IGF2, and target gene IGF1 in primary hepatocytes and in the liver of Wistar female rats was investigated.	Benzo(a)pyrene	14-16	insulin-like growth factor 2	Rattus norvegicus	78-82
31694515-2	2019	The effect of BP on the expression of the oncogenic miR-483-3p, its host gene IGF2, and target gene IGF1 in primary hepatocytes and in the liver of Wistar female rats was investigated.	Benzo(a)pyrene	14-16	insulin-like growth factor 1	Rattus norvegicus	100-104
31694515-5	2019	Our results confirm the existence of the AhR-mediated pathway in the regulation of expression of miR-483-3p, IGF1, and IGF2 under BP exposure, which is of considerable interest for understanding the epigenetic mechanisms of the carcinogenic effect of BP.	Benzo(a)pyrene	130-132	aryl hydrocarbon receptor	Rattus norvegicus	41-44
31694515-5	2019	Our results confirm the existence of the AhR-mediated pathway in the regulation of expression of miR-483-3p, IGF1, and IGF2 under BP exposure, which is of considerable interest for understanding the epigenetic mechanisms of the carcinogenic effect of BP.	Benzo(a)pyrene	130-132	insulin-like growth factor 1	Rattus norvegicus	109-113
31694515-5	2019	Our results confirm the existence of the AhR-mediated pathway in the regulation of expression of miR-483-3p, IGF1, and IGF2 under BP exposure, which is of considerable interest for understanding the epigenetic mechanisms of the carcinogenic effect of BP.	Benzo(a)pyrene	130-132	insulin-like growth factor 2	Rattus norvegicus	119-123
31694515-5	2019	Our results confirm the existence of the AhR-mediated pathway in the regulation of expression of miR-483-3p, IGF1, and IGF2 under BP exposure, which is of considerable interest for understanding the epigenetic mechanisms of the carcinogenic effect of BP.	Benzo(a)pyrene	251-253	aryl hydrocarbon receptor	Rattus norvegicus	41-44
31279923-10	2019	These results suggest that BaP enhances aortic vasoconstriction via the activation of ROS and muscular signaling molecules PKC, MAPK, MLCK, and Rho-kinase.	Benzo(a)pyrene	27-30	myosin light chain kinase	Rattus norvegicus	134-138
31453997-1	2019	Black Phosphorous (BP) has intrinsic in-plane ferroelectric properties that may have the inherent capability of SERS response and can be considered as a replacement of metal nanoparticle-based SERS substrates.	Benzo(a)pyrene	19-21	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	112-116
31453997-1	2019	Black Phosphorous (BP) has intrinsic in-plane ferroelectric properties that may have the inherent capability of SERS response and can be considered as a replacement of metal nanoparticle-based SERS substrates.	Benzo(a)pyrene	19-21	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	193-197
31255691-5	2019	Specifically, BAP upregulated targets of AhR, NRF2, and KLF4, while DBC downregulated these same targets, suggesting a chemical-specific pattern in transcriptional regulation involved in antioxidant response, potentially contributing to differences in PAH potency.	Benzo(a)pyrene	14-17	aryl hydrocarbon receptor	Homo sapiens	41-44
31255691-5	2019	Specifically, BAP upregulated targets of AhR, NRF2, and KLF4, while DBC downregulated these same targets, suggesting a chemical-specific pattern in transcriptional regulation involved in antioxidant response, potentially contributing to differences in PAH potency.	Benzo(a)pyrene	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
31255691-5	2019	Specifically, BAP upregulated targets of AhR, NRF2, and KLF4, while DBC downregulated these same targets, suggesting a chemical-specific pattern in transcriptional regulation involved in antioxidant response, potentially contributing to differences in PAH potency.	Benzo(a)pyrene	14-17	Kruppel like factor 4	Homo sapiens	56-60
31328511-7	2019	The potency balance analysis showed that newly identified AhR agonists explained 0.07-16% of bioassay-derived BaP-EQs.	Benzo(a)pyrene	110-113	aryl hydrocarbon receptor	Homo sapiens	58-61
30982974-0	2019	Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	106-131
30982974-6	2019	The role of aryl hydrocarbon receptor (AhR) signaling in BaP-promoted Der f 1-induced ROS, cytokine production, and allergic inflammation was also investigated.	Benzo(a)pyrene	57-60	aryl-hydrocarbon receptor	Mus musculus	39-42
30982974-9	2019	Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression.	Benzo(a)pyrene	10-13	aryl-hydrocarbon receptor	Mus musculus	49-52
30982974-9	2019	Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression.	Benzo(a)pyrene	10-13	aryl-hydrocarbon receptor	Mus musculus	92-95
30982974-9	2019	Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression.	Benzo(a)pyrene	10-13	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	100-106
30982974-9	2019	Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression.	Benzo(a)pyrene	10-13	thymic stromal lymphopoietin	Mus musculus	157-161
30982974-9	2019	Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression.	Benzo(a)pyrene	10-13	interleukin 33	Mus musculus	166-171
30982974-11	2019	Furthermore, ROS inhibitor N-acetyl-L-cysteine (NAC) also suppressed BaP co-exposure-induced expression of epithelial TSLP, IL-33, and IL-25.	Benzo(a)pyrene	69-72	thymic stromal lymphopoietin	Mus musculus	118-122
30982974-11	2019	Furthermore, ROS inhibitor N-acetyl-L-cysteine (NAC) also suppressed BaP co-exposure-induced expression of epithelial TSLP, IL-33, and IL-25.	Benzo(a)pyrene	69-72	interleukin 33	Mus musculus	124-129
30982974-11	2019	Furthermore, ROS inhibitor N-acetyl-L-cysteine (NAC) also suppressed BaP co-exposure-induced expression of epithelial TSLP, IL-33, and IL-25.	Benzo(a)pyrene	69-72	interleukin 25	Mus musculus	135-140
30982974-12	2019	Finally, AhR antagonist CH223191 and NAC inhibited BaP co-exposure with Der f 1-induced lung inflammation.	Benzo(a)pyrene	51-54	aryl-hydrocarbon receptor	Mus musculus	9-12
30982974-13	2019	CONCLUSIONS: Our findings suggest that BaP facilitates Der f 1-induced epithelial cytokine release through the AhR-ROS axis.	Benzo(a)pyrene	39-42	aryl-hydrocarbon receptor	Mus musculus	111-114
31503666-0	2019	AuAg alloy film-based colorful SPR imaging sensor for highly sensitive immunodetection of benzo[a]pyrene in water.	Benzo(a)pyrene	90-104	sepiapterin reductase	Homo sapiens	31-34
31503666-6	2019	According to the experimental results, the average hue of the SPR color image (300  pixelsx300  pixels) experiences an initial rapid increase and then stabilizes 15 min after exposure of the functionalized AuAg alloy film to an aqueous BaP solution sample.	Benzo(a)pyrene	236-239	sepiapterin reductase	Homo sapiens	62-65
31185349-2	2019	Previously, we identified aberrant methylation of the fms related tyrosine kinase 1 (FLT1) gene over the course of benzo(a)pyrene (BaP)-induced cell transformation via genome-wide methylation array.	Benzo(a)pyrene	131-134	fms related receptor tyrosine kinase 1	Homo sapiens	85-89
31387194-6	2019	BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition.	Benzo(a)pyrene	0-2	NAD(P)H quinone dehydrogenase 1	Homo sapiens	30-34
31387194-6	2019	BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition.	Benzo(a)pyrene	0-2	thioredoxin reductase 1	Homo sapiens	36-42
31387194-6	2019	BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition.	Benzo(a)pyrene	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
31387194-6	2019	BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition.	Benzo(a)pyrene	0-2	tumor necrosis factor	Homo sapiens	83-92
31387194-6	2019	BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition.	Benzo(a)pyrene	0-2	interleukin 6	Homo sapiens	97-101
31185349-2	2019	Previously, we identified aberrant methylation of the fms related tyrosine kinase 1 (FLT1) gene over the course of benzo(a)pyrene (BaP)-induced cell transformation via genome-wide methylation array.	Benzo(a)pyrene	115-129	fms related receptor tyrosine kinase 1	Homo sapiens	85-89
31391346-7	2019	Further supporting the therapeutic potential of Coversin in humans, we found that C5a and LTB4 are both present in the blister fluid of patients with BP in quantities inducing the recruitment of granulocytes and that the number of cells expressing their receptors, C5aR1 and BLT1, respectively, is increased in perilesional skin.	Benzo(a)pyrene	150-152	complement C5a receptor 1	Homo sapiens	82-85
31025704-8	2019	The GCF SEMA4D and PAD2 total amounts in the BP group were significantly greater than the NBP group (P   0.05).	Benzo(a)pyrene	45-47	semaphorin 4D	Homo sapiens	8-14
31025704-8	2019	The GCF SEMA4D and PAD2 total amounts in the BP group were significantly greater than the NBP group (P   0.05).	Benzo(a)pyrene	45-47	peptidyl arginine deiminase 2	Homo sapiens	19-23
31051210-4	2019	The parameters measured covered key events relevant to the AOP developed for Benzo(a)pyrene: AhR activation, mutagenicity and DNA-damage with and without metabolic activation and endocrine receptors activation/inhibition.	Benzo(a)pyrene	77-91	aryl hydrocarbon receptor	Homo sapiens	93-96
31176714-1	2019	Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD).	Benzo(a)pyrene	176-190	aryl hydrocarbon receptor	Homo sapiens	0-25
31176714-1	2019	Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD).	Benzo(a)pyrene	176-190	aryl hydrocarbon receptor	Homo sapiens	27-30
31176714-1	2019	Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD).	Benzo(a)pyrene	192-195	aryl hydrocarbon receptor	Homo sapiens	0-25
31176714-1	2019	Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD).	Benzo(a)pyrene	192-195	aryl hydrocarbon receptor	Homo sapiens	27-30
31059956-8	2019	Furthermore, BaP-exposed male mice were mated with unexposed female mice to generate F1-2 generations.	Benzo(a)pyrene	13-16	coagulation factor XII (Hageman factor)	Mus musculus	85-89
31059956-0	2019	Paternal benzo[a]pyrene exposure alters the sperm DNA methylation levels of imprinting genes in F0 generation mice and their unexposed F1-2 male offspring.	Benzo(a)pyrene	9-23	coagulation factor XII (Hageman factor)	Mus musculus	135-139
31059956-6	2019	The methylation status of 6 imprinting genes (H19, Meg3, Peg1, Peg3, Igf2 and Snrpn) was examined by bisulfite pyrosequencing of the sperm DNA of BaP-exposed F0 generation and their offspring.	Benzo(a)pyrene	146-149	insulin-like growth factor 2	Mus musculus	69-73
31059956-6	2019	The methylation status of 6 imprinting genes (H19, Meg3, Peg1, Peg3, Igf2 and Snrpn) was examined by bisulfite pyrosequencing of the sperm DNA of BaP-exposed F0 generation and their offspring.	Benzo(a)pyrene	146-149	small nuclear ribonucleoprotein N	Mus musculus	78-83
31059956-7	2019	RESULTS: BaP exposure reduced the methylation levels in the imprinting genes H19 and Meg3 and increased the methylation levels of Peg1 and Peg3; however, no significant differences was observed for the methylation levels of Igf2 or Snrpn in the sperm DNA.	Benzo(a)pyrene	9-12	maternally expressed 3	Mus musculus	85-89
31059956-7	2019	RESULTS: BaP exposure reduced the methylation levels in the imprinting genes H19 and Meg3 and increased the methylation levels of Peg1 and Peg3; however, no significant differences was observed for the methylation levels of Igf2 or Snrpn in the sperm DNA.	Benzo(a)pyrene	9-12	mesoderm specific transcript	Mus musculus	130-134
31059956-7	2019	RESULTS: BaP exposure reduced the methylation levels in the imprinting genes H19 and Meg3 and increased the methylation levels of Peg1 and Peg3; however, no significant differences was observed for the methylation levels of Igf2 or Snrpn in the sperm DNA.	Benzo(a)pyrene	9-12	paternally expressed 3	Mus musculus	139-143
31059956-7	2019	RESULTS: BaP exposure reduced the methylation levels in the imprinting genes H19 and Meg3 and increased the methylation levels of Peg1 and Peg3; however, no significant differences was observed for the methylation levels of Igf2 or Snrpn in the sperm DNA.	Benzo(a)pyrene	9-12	small nuclear ribonucleoprotein N	Mus musculus	232-237
31187260-10	2019	The knowledge of these effects of CNP could lead to improved therapeutic strategies to not only control BP but also reduce vascular damage, primarily responsible for the risk of cardiovascular events.	Benzo(a)pyrene	104-106	natriuretic peptide C	Rattus norvegicus	34-37
31085209-0	2019	BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1alpha pathway in spermatogenic cells both in vitro and in vivo.	Benzo(a)pyrene	9-14	sirtuin 1	Sus scrofa	82-87
31085209-0	2019	BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1alpha pathway in spermatogenic cells both in vitro and in vivo.	Benzo(a)pyrene	9-14	telomerase reverse transcriptase	Sus scrofa	88-92
31086989-1	2019	Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified.	Benzo(a)pyrene	117-131	aryl-hydrocarbon receptor	Mus musculus	195-220
31086989-1	2019	Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified.	Benzo(a)pyrene	117-131	aryl-hydrocarbon receptor	Mus musculus	222-225
31085209-0	2019	BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1alpha pathway in spermatogenic cells both in vitro and in vivo.	Benzo(a)pyrene	9-14	PPARG coactivator 1 alpha	Sus scrofa	93-103
31085209-11	2019	B[a]P administration caused mitochondrial damage and mitochondria-dependent apoptosis in spermatogenic cells, as well as the decreased expression of SIRT1, TERT, and PGC-1alpha.	Benzo(a)pyrene	0-5	sirtuin 1	Rattus norvegicus	149-154
31085209-11	2019	B[a]P administration caused mitochondrial damage and mitochondria-dependent apoptosis in spermatogenic cells, as well as the decreased expression of SIRT1, TERT, and PGC-1alpha.	Benzo(a)pyrene	0-5	telomerase reverse transcriptase	Rattus norvegicus	156-160
31085209-11	2019	B[a]P administration caused mitochondrial damage and mitochondria-dependent apoptosis in spermatogenic cells, as well as the decreased expression of SIRT1, TERT, and PGC-1alpha.	Benzo(a)pyrene	0-5	PPARG coactivator 1 alpha	Rattus norvegicus	166-176
31368503-5	2019	Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR).	Benzo(a)pyrene	118-132	aryl hydrocarbon receptor	Rattus norvegicus	85-110
31368503-5	2019	Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR).	Benzo(a)pyrene	118-132	aryl hydrocarbon receptor	Rattus norvegicus	112-115
31368503-5	2019	Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR).	Benzo(a)pyrene	134-136	aryl hydrocarbon receptor	Rattus norvegicus	112-115
31338364-11	2019	High resolution mass spectrometry (HRMS) was utilized to confirm that putative nucleic acid adducts detected in both DNA and RNA were derived from benzo[a]pyrene exposure and these putative adducts were identified as 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene- (B[a]PDE)-type adducts.	Benzo(a)pyrene	147-161	aldehyde dehydrogenase 7 family member A1	Homo sapiens	282-285
31288844-3	2019	METHODS: The mouse model for the study of inflammation-associated GC was induced by Benzo[a]pyrene (BaP) intragastric administration in Bcl6b-/- and wildtype mice on a C57BL/6 background.	Benzo(a)pyrene	100-103	B cell CLL/lymphoma 6, member B	Mus musculus	136-141
31288844-6	2019	RESULTS: Bcl6b was gradually downregulated by its own promoter hypermethylation in parallel to an increasing inflammatory response during the progression of BaP-induced gastric carcinogenesis in mice.	Benzo(a)pyrene	157-160	B cell CLL/lymphoma 6, member B	Mus musculus	9-14
31288844-7	2019	Moreover, knockout of Bcl6b dramatically worsened the severity of gastric cancer and aggravated the inflammatory response in the BaP-induced mice GC model.	Benzo(a)pyrene	129-132	B cell CLL/lymphoma 6, member B	Mus musculus	22-27
31288844-8	2019	Re-activation of Bcl6b by 5-Aza impeded inflammatory amplification and BaP-induced GC development, prolonging survival time in wildtype mice, whereas no notable curative effect occurred in Bcl6b-/- mice with 5-Aza treatment.	Benzo(a)pyrene	71-74	B cell CLL/lymphoma 6, member B	Mus musculus	17-22
31360208-4	2019	We also noticed that BP restored Ox-LDL-stimulated HUVECs oxidative stress, by induced antioxidant gene expressions, including Heme oxygenase-1 and its upstream mediator, Nrf2, which were mediated by the activation of the phosphorylation of PI3K/Akt/mTOR.	Benzo(a)pyrene	21-23	heme oxygenase 1	Homo sapiens	127-143
31360208-4	2019	We also noticed that BP restored Ox-LDL-stimulated HUVECs oxidative stress, by induced antioxidant gene expressions, including Heme oxygenase-1 and its upstream mediator, Nrf2, which were mediated by the activation of the phosphorylation of PI3K/Akt/mTOR.	Benzo(a)pyrene	21-23	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175
31360208-4	2019	We also noticed that BP restored Ox-LDL-stimulated HUVECs oxidative stress, by induced antioxidant gene expressions, including Heme oxygenase-1 and its upstream mediator, Nrf2, which were mediated by the activation of the phosphorylation of PI3K/Akt/mTOR.	Benzo(a)pyrene	21-23	AKT serine/threonine kinase 1	Homo sapiens	246-249
31360208-4	2019	We also noticed that BP restored Ox-LDL-stimulated HUVECs oxidative stress, by induced antioxidant gene expressions, including Heme oxygenase-1 and its upstream mediator, Nrf2, which were mediated by the activation of the phosphorylation of PI3K/Akt/mTOR.	Benzo(a)pyrene	21-23	mechanistic target of rapamycin kinase	Homo sapiens	250-254
31360208-6	2019	Our results demonstrated that BP protected HUVECs against oxidative damage partly via PI3K/Akt/mTOR-mediated Nrf/HO-1 pathway, which might be applied into preventing Ox-LDL mediated cardiovascular diseases.	Benzo(a)pyrene	30-32	AKT serine/threonine kinase 1	Homo sapiens	91-94
31360208-6	2019	Our results demonstrated that BP protected HUVECs against oxidative damage partly via PI3K/Akt/mTOR-mediated Nrf/HO-1 pathway, which might be applied into preventing Ox-LDL mediated cardiovascular diseases.	Benzo(a)pyrene	30-32	mechanistic target of rapamycin kinase	Homo sapiens	95-99
31360208-6	2019	Our results demonstrated that BP protected HUVECs against oxidative damage partly via PI3K/Akt/mTOR-mediated Nrf/HO-1 pathway, which might be applied into preventing Ox-LDL mediated cardiovascular diseases.	Benzo(a)pyrene	30-32	heme oxygenase 1	Homo sapiens	113-117
30748024-0	2019	Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T-helper 2-driven proinflammatory responses in a mouse model of allergic dermatitis.	Benzo(a)pyrene	50-64	aryl-hydrocarbon receptor	Mus musculus	21-46
31264964-2	2019	Here we identify a large sample of published drug-gene interaction claims curated in the Comparative Toxicogenomics Database (for example, benzo(a)pyrene decreases expression of SLC22A3) and evaluate these claims by connecting them with high-throughput experiments from the LINCS L1000 program.	Benzo(a)pyrene	139-153	solute carrier family 22 member 3	Homo sapiens	178-185
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	49-63	aryl hydrocarbon receptor	Homo sapiens	103-128
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	49-63	aryl hydrocarbon receptor	Homo sapiens	130-133
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	49-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	161-176
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	49-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	178-181
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	65-68	aryl hydrocarbon receptor	Homo sapiens	103-128
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	65-68	aryl hydrocarbon receptor	Homo sapiens	130-133
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	65-68	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	161-176
31111189-3	2019	Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity.	Benzo(a)pyrene	65-68	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	178-181
30982342-2	2019	Benzo(a)pyrene (BaP) is one of the most representative air pollutants and has aroused wide concern because of its strong carcinogenicity.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
30862515-0	2019	Human placental extract ameliorates cytokine and cytokine receptor signaling in the rat hippocampus upon Benzo[a]Pyrene exposure.	Benzo(a)pyrene	105-119	interleukin 18 receptor 1	Homo sapiens	49-66
30862515-1	2019	Benzo[alpha]Pyrene (B[a]P) causes toxicity via Cytochrome P450 1A1 (CYP1A1) metabolic activity in the brain.	Benzo(a)pyrene	20-25	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-66
30862515-1	2019	Benzo[alpha]Pyrene (B[a]P) causes toxicity via Cytochrome P450 1A1 (CYP1A1) metabolic activity in the brain.	Benzo(a)pyrene	20-25	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	68-74
30862515-7	2019	Herein we report that 5 mul of 0.1 gm HPE followed by 0.25 muM B[a]P administration enabled down-regulation of IL-2 and TNF-alpha levels in the hippocampus thereby modulating TNFR2 and IL2Rgammac signals via NF-kappaB activation.	Benzo(a)pyrene	63-68	interleukin 2	Homo sapiens	111-115
30862515-7	2019	Herein we report that 5 mul of 0.1 gm HPE followed by 0.25 muM B[a]P administration enabled down-regulation of IL-2 and TNF-alpha levels in the hippocampus thereby modulating TNFR2 and IL2Rgammac signals via NF-kappaB activation.	Benzo(a)pyrene	63-68	tumor necrosis factor	Homo sapiens	120-129
30862515-7	2019	Herein we report that 5 mul of 0.1 gm HPE followed by 0.25 muM B[a]P administration enabled down-regulation of IL-2 and TNF-alpha levels in the hippocampus thereby modulating TNFR2 and IL2Rgammac signals via NF-kappaB activation.	Benzo(a)pyrene	63-68	TNF receptor superfamily member 1B	Homo sapiens	175-180
30862515-7	2019	Herein we report that 5 mul of 0.1 gm HPE followed by 0.25 muM B[a]P administration enabled down-regulation of IL-2 and TNF-alpha levels in the hippocampus thereby modulating TNFR2 and IL2Rgammac signals via NF-kappaB activation.	Benzo(a)pyrene	63-68	nuclear factor kappa B subunit 1	Homo sapiens	208-217
31242870-10	2019	We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p &lt;  0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p &lt;  0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p &gt; 0.05).	Benzo(a)pyrene	82-84	ATPase plasma membrane Ca2+ transporting 1	Homo sapiens	22-28
31240266-2	2019	We used next-generation sequencing and comparative genomic hybridization arrays to investigate genome-wide mutations in the offspring of male mice exposed to benzo(a)pyrene (BaP), a common environmental pollutant.	Benzo(a)pyrene	158-172	prohibitin 2	Mus musculus	174-177
30748024-5	2019	Benzo[a]pyrene (BaP) and 6-formylindolo[3,2-b]carbazole were used as selective ligands for the AhR.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	95-98
30748024-5	2019	Benzo[a]pyrene (BaP) and 6-formylindolo[3,2-b]carbazole were used as selective ligands for the AhR.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	95-98
30748024-6	2019	Pretreatment with BaP and/or 6-formylindolo[3,2-b]carbazole significantly induced cytokine release by activated keratinocytes and T-cell proliferation, whereas interleukin-12 production in bone marrow-derived dendritic cells was reduced by AhR activation.	Benzo(a)pyrene	18-21	aryl hydrocarbon receptor	Homo sapiens	240-243
31142653-1	2019	Benzo[a]pyrene (BaP), a key polycyclic aromatic hydrocarbon (PAH) often associated with soot particles coated by organic compounds, is a known carcinogen and mutagen.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
30614051-3	2019	AAA in male C57BL/6 J mice was induced by coadministration of angiotensin II (Ang II) and 3,4-benzopyrene (BaP).	Benzo(a)pyrene	90-105	prohibitin 2	Mus musculus	107-110
30811740-0	2019	Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells.	Benzo(a)pyrene	10-24	tumor protein p53 inducible nuclear protein 1	Homo sapiens	94-102
30811740-0	2019	Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells.	Benzo(a)pyrene	10-24	microRNA 126	Homo sapiens	46-53
30811740-0	2019	Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells.	Benzo(a)pyrene	10-24	microRNA 190a	Homo sapiens	55-63
30811740-0	2019	Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells.	Benzo(a)pyrene	10-24	EGF like domain multiple 7	Homo sapiens	87-92
30811740-0	2019	Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells.	Benzo(a)pyrene	10-24	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	107-113
30811740-2	2019	MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment.	Benzo(a)pyrene	59-61	microRNA 126	Homo sapiens	0-12
30811740-2	2019	MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment.	Benzo(a)pyrene	59-61	microRNA 126	Homo sapiens	14-21
30811740-2	2019	MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment.	Benzo(a)pyrene	59-61	microRNA 190a	Homo sapiens	27-35
30811740-3	2019	The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level.	Benzo(a)pyrene	36-38	microRNA 126	Homo sapiens	72-79
30811740-3	2019	The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level.	Benzo(a)pyrene	36-38	EGF like domain multiple 7	Homo sapiens	105-110
30811740-4	2019	BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes.	Benzo(a)pyrene	0-2	microRNA 190a	Homo sapiens	27-35
30811740-4	2019	BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes.	Benzo(a)pyrene	0-2	tumor protein p53 inducible nuclear protein 1	Homo sapiens	125-133
30811740-4	2019	BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes.	Benzo(a)pyrene	0-2	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	138-144
30811740-5	2019	Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP.	Benzo(a)pyrene	25-27	microRNA 190a	Homo sapiens	132-140
30811740-5	2019	Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP.	Benzo(a)pyrene	185-187	microRNA 190a	Homo sapiens	132-140
30811740-6	2019	The findings of this study indicate that miR-190a and its target genes may be involved in the regulation of cell fate under BP treatment.	Benzo(a)pyrene	124-126	microRNA 190a	Homo sapiens	41-49
30771939-6	2019	Under optimal conditions, standard curves of rhodamine B and benzo[a]pyrene showed a linear relationship in concentration ranges of 10-800 mug L-1 (R2 = 0.99) and 0.07-3.33 mug L-1 (R2 = 0.99), respectively.	Benzo(a)pyrene	61-75	immunoglobulin kappa variable 1-16	Homo sapiens	143-146
30771939-6	2019	Under optimal conditions, standard curves of rhodamine B and benzo[a]pyrene showed a linear relationship in concentration ranges of 10-800 mug L-1 (R2 = 0.99) and 0.07-3.33 mug L-1 (R2 = 0.99), respectively.	Benzo(a)pyrene	61-75	immunoglobulin kappa variable 1-16	Homo sapiens	177-180
31130856-0	2019	Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure.	Benzo(a)pyrene	131-145	poly (ADP-ribose) glycohydrolase	Mus musculus	39-71
31138742-0	2019	Cytochrome P450 Monooxygenase-Mediated Metabolic Utilization of Benzo[a]Pyrene by Aspergillus Species.	Benzo(a)pyrene	64-78	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	0-29
31138742-5	2019	Importantly, we identify and characterize the conserved bapA gene encoding a cytochrome P450 monooxygenase that is necessary for the metabolic utilization of BaP in Aspergillus We further demonstrate that the fungal NF-kappaB-type velvet regulators VeA and VelB are required for proper expression of bapA in response to nutrient limitation and BaP degradation in A. nidulans Our study illuminates fundamental knowledge of fungal BaP metabolism and provides novel insights into enhancing bioremediation potential.IMPORTANCE We are increasingly exposed to environmental pollutants, including the carcinogen benzo[a]pyrene (BaP), which has prompted extensive research into human metabolism of toxicants.	Benzo(a)pyrene	158-161	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	77-106
31138742-5	2019	Importantly, we identify and characterize the conserved bapA gene encoding a cytochrome P450 monooxygenase that is necessary for the metabolic utilization of BaP in Aspergillus We further demonstrate that the fungal NF-kappaB-type velvet regulators VeA and VelB are required for proper expression of bapA in response to nutrient limitation and BaP degradation in A. nidulans Our study illuminates fundamental knowledge of fungal BaP metabolism and provides novel insights into enhancing bioremediation potential.IMPORTANCE We are increasingly exposed to environmental pollutants, including the carcinogen benzo[a]pyrene (BaP), which has prompted extensive research into human metabolism of toxicants.	Benzo(a)pyrene	605-619	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	77-106
31138742-5	2019	Importantly, we identify and characterize the conserved bapA gene encoding a cytochrome P450 monooxygenase that is necessary for the metabolic utilization of BaP in Aspergillus We further demonstrate that the fungal NF-kappaB-type velvet regulators VeA and VelB are required for proper expression of bapA in response to nutrient limitation and BaP degradation in A. nidulans Our study illuminates fundamental knowledge of fungal BaP metabolism and provides novel insights into enhancing bioremediation potential.IMPORTANCE We are increasingly exposed to environmental pollutants, including the carcinogen benzo[a]pyrene (BaP), which has prompted extensive research into human metabolism of toxicants.	Benzo(a)pyrene	344-347	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	77-106
31138742-8	2019	Importantly, this study reveals key components of the metabolic utilization of BaP, notably a cytochrome P450 monooxygenase and the fungal NF-kappaB-type transcriptional regulators.	Benzo(a)pyrene	79-82	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	94-123
31092429-0	2019	Diallyl Trisulfide Enhances Benzo[a]pyrene-induced CYP1A1 Expression and Metabolic Activation in Hepatic HepG2 Cells.	Benzo(a)pyrene	28-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-57
31092429-1	2019	BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	16-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-146
31092429-1	2019	BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	16-30	aryl hydrocarbon receptor	Homo sapiens	169-194
31130856-0	2019	Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure.	Benzo(a)pyrene	131-145	poly (ADP-ribose) glycohydrolase	Mus musculus	73-77
31092429-1	2019	BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	16-30	aryl hydrocarbon receptor	Homo sapiens	196-199
31092429-1	2019	BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	32-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-146
31092429-1	2019	BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	32-35	aryl hydrocarbon receptor	Homo sapiens	169-194
31130856-2	2019	Poly (ADP-ribosylation), as a key post-translational modification in BaP-induced carcinogenesis, is mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) in eukaryotic organisms.	Benzo(a)pyrene	69-72	poly (ADP-ribose) glycohydrolase	Mus musculus	120-152
31092429-1	2019	BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	32-35	aryl hydrocarbon receptor	Homo sapiens	196-199
31130856-2	2019	Poly (ADP-ribosylation), as a key post-translational modification in BaP-induced carcinogenesis, is mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) in eukaryotic organisms.	Benzo(a)pyrene	69-72	poly (ADP-ribose) glycohydrolase	Mus musculus	154-158
31092429-2	2019	Induced CYP1A1 is involved in BaP metabolism, resulting in either detoxification or metabolic activation in a context-dependent manner.	Benzo(a)pyrene	30-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	8-14
31092429-5	2019	RESULTS: DATS enhanced BaP-induced CYP1A1 and CYP1B1 mRNA expression, BaP hydroxylation and BaP-DNA adduct formation.	Benzo(a)pyrene	23-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-41
31130856-3	2019	Previously, it is found that PARG silencing can counteract BaP-induced carcinogenesis in vitro, but the mechanism remained unclear.	Benzo(a)pyrene	59-62	poly (ADP-ribose) glycohydrolase	Mus musculus	29-33
31092429-5	2019	RESULTS: DATS enhanced BaP-induced CYP1A1 and CYP1B1 mRNA expression, BaP hydroxylation and BaP-DNA adduct formation.	Benzo(a)pyrene	23-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52
31130856-7	2019	These results indicate that PARG gene silencing protects mice against lung cancer induced by BaP inhalation exposure.	Benzo(a)pyrene	93-96	poly (ADP-ribose) glycohydrolase	Mus musculus	28-32
31092429-7	2019	DATS enhanced BaP-induced AHR recruitment and histone H3 acetylation on the CYP1A1 promoter.	Benzo(a)pyrene	14-17	aryl hydrocarbon receptor	Homo sapiens	26-29
31130856-10	2019	Meanwhile, the relative expression of Wnt2b and Wnt5b proteins, as assessed by immunohistochemistry and Western blot analysis, was significantly up-regulated by BaP in WT mice; while in PARG+/- mice it was not statistically affected.	Benzo(a)pyrene	161-164	wingless-type MMTV integration site family, member 2B	Mus musculus	38-43
31092429-7	2019	DATS enhanced BaP-induced AHR recruitment and histone H3 acetylation on the CYP1A1 promoter.	Benzo(a)pyrene	14-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-82
31092429-8	2019	CONCLUSION: DATS combined treatment enhances BaP metabolic activation through an AHR-modulating mechanism.	Benzo(a)pyrene	45-48	aryl hydrocarbon receptor	Homo sapiens	81-84
31130856-10	2019	Meanwhile, the relative expression of Wnt2b and Wnt5b proteins, as assessed by immunohistochemistry and Western blot analysis, was significantly up-regulated by BaP in WT mice; while in PARG+/- mice it was not statistically affected.	Benzo(a)pyrene	161-164	wingless-type MMTV integration site family, member 5B	Mus musculus	48-53
31130856-10	2019	Meanwhile, the relative expression of Wnt2b and Wnt5b proteins, as assessed by immunohistochemistry and Western blot analysis, was significantly up-regulated by BaP in WT mice; while in PARG+/- mice it was not statistically affected.	Benzo(a)pyrene	161-164	poly (ADP-ribose) glycohydrolase	Mus musculus	186-190
31130856-11	2019	Our work provides initial evidence that PARG silencing suppresses BaP induced lung cancer and stabilizes the expression of Wnt ligands, PARG gene and Wnt ligands may provide new options for the diagnosis and treatment of lung cancer.	Benzo(a)pyrene	66-69	poly (ADP-ribose) glycohydrolase	Mus musculus	40-44
31114548-2	2019	In this study the molecular mechanism of B(a)P induced Leydig cell steroidogenic dysfunctions and its protective mechanism of action with a natural Aryl hydrocarbon receptor (AhR) antagonist and anti-oxidant, Resveratrol (Res) has been investigated.	Benzo(a)pyrene	41-46	aryl hydrocarbon receptor	Homo sapiens	148-173
30620413-1	2019	In vitro studies indicate that DNA polymerase kappa (Polkappa) is able to accurately and efficiently perform DNA synthesis using templates containing various types of DNA damage, including benzo[a]pyrene (BP)-induced N2 -deoxyguanosine adducts.	Benzo(a)pyrene	189-203	polymerase (DNA directed), kappa	Mus musculus	31-51
30620413-1	2019	In vitro studies indicate that DNA polymerase kappa (Polkappa) is able to accurately and efficiently perform DNA synthesis using templates containing various types of DNA damage, including benzo[a]pyrene (BP)-induced N2 -deoxyguanosine adducts.	Benzo(a)pyrene	205-207	polymerase (DNA directed), kappa	Mus musculus	31-51
30620413-2	2019	In this study, we examined sensitivity of inactivated Polk knock-in (Polk-/- ) mice to BP carcinogenicity in the colon by administering an oral dose of BP plus dextran sulfate sodium (DSS), an inflammation causing promoter of carcinogenesis.	Benzo(a)pyrene	87-89	polymerase (DNA directed), kappa	Mus musculus	54-58
31114548-2	2019	In this study the molecular mechanism of B(a)P induced Leydig cell steroidogenic dysfunctions and its protective mechanism of action with a natural Aryl hydrocarbon receptor (AhR) antagonist and anti-oxidant, Resveratrol (Res) has been investigated.	Benzo(a)pyrene	41-46	aryl hydrocarbon receptor	Homo sapiens	175-178
30553920-6	2019	As a methodology demonstration, the health risk of typical binary polycyclic aromatic hydrocarbon (PAH) mixtures in PM, containing Benzo[a]pyrene (BaP) as a component, is assessed using the proposed solution.	Benzo(a)pyrene	131-145	prohibitin 2	Homo sapiens	147-150
31010609-11	2019	Benzo[a]pyrene significantly and synergistically enhanced the scratch-induced CCL20 secretion that may explain why smoking is a risk factor for psoriasis.	Benzo(a)pyrene	0-14	C-C motif chemokine ligand 20	Homo sapiens	78-83
30905618-3	2019	We identify human membrane-bound PALMDELPHIN (PALMD-Caax) as an underlying factor, and we show that it drives BP process growth and proliferation when expressed in developing mouse and ferret Ncx.	Benzo(a)pyrene	110-112	palmdelphin	Homo sapiens	33-44
30905618-3	2019	We identify human membrane-bound PALMDELPHIN (PALMD-Caax) as an underlying factor, and we show that it drives BP process growth and proliferation when expressed in developing mouse and ferret Ncx.	Benzo(a)pyrene	110-112	palmdelphin	Homo sapiens	33-38
30634150-5	2019	The release of pro-inflammatory cytokines interleukin 6 and tumor necrosis factor alpha was also elevated in BaP-treated offspring.	Benzo(a)pyrene	109-112	tumor necrosis factor	Mus musculus	15-87
30634150-6	2019	Further, lactational exposure to BaP decreased the level of glutathione and the expressions of antioxidant genes (Thioredoxin 1 and Glutaredoxin 2) in male offspring.	Benzo(a)pyrene	33-36	thioredoxin 1	Mus musculus	114-127
30785444-11	2019	Furthermore, BP reversed the decline of PGC-1alpha expression induced by NAFLD, while SIRT1 silencing significantly suppressed the effects of BP on PGC-1alpha.	Benzo(a)pyrene	13-15	PPARG coactivator 1 alpha	Rattus norvegicus	40-50
29931584-9	2019	An increased expression of CYP1A1 in liver and colon and of CYP1B1 in liver of BaP-treated mice was seen, while RVT inhibited the extent of biotransformation mediated by these enzymes in the respective tissue samples.	Benzo(a)pyrene	79-82	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	27-33
29931584-9	2019	An increased expression of CYP1A1 in liver and colon and of CYP1B1 in liver of BaP-treated mice was seen, while RVT inhibited the extent of biotransformation mediated by these enzymes in the respective tissue samples.	Benzo(a)pyrene	79-82	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	60-66
29931584-10	2019	In the case of GST, an increased expression in colon of BaP alone-treated mice was noted when RVT was administered prior to BaP or simultaneously with BaP.	Benzo(a)pyrene	56-59	hematopoietic prostaglandin D synthase	Mus musculus	15-18
29931584-10	2019	In the case of GST, an increased expression in colon of BaP alone-treated mice was noted when RVT was administered prior to BaP or simultaneously with BaP.	Benzo(a)pyrene	124-127	hematopoietic prostaglandin D synthase	Mus musculus	15-18
29931584-10	2019	In the case of GST, an increased expression in colon of BaP alone-treated mice was noted when RVT was administered prior to BaP or simultaneously with BaP.	Benzo(a)pyrene	124-127	hematopoietic prostaglandin D synthase	Mus musculus	15-18
30729964-5	2019	In this study, we investigate the interaction of LS models with benzo[a]pyrene (BaP).	Benzo(a)pyrene	64-78	prohibitin 2	Homo sapiens	80-83
30785444-11	2019	Furthermore, BP reversed the decline of PGC-1alpha expression induced by NAFLD, while SIRT1 silencing significantly suppressed the effects of BP on PGC-1alpha.	Benzo(a)pyrene	142-144	sirtuin 1	Rattus norvegicus	86-91
30785444-11	2019	Furthermore, BP reversed the decline of PGC-1alpha expression induced by NAFLD, while SIRT1 silencing significantly suppressed the effects of BP on PGC-1alpha.	Benzo(a)pyrene	142-144	PPARG coactivator 1 alpha	Rattus norvegicus	148-158
30785444-12	2019	In conclusion, BP might effectively protect rats against mitochondrial dysfunction during NAFLD as potential ingredients of functional food, by modulating the SIRT1 expression.	Benzo(a)pyrene	15-17	sirtuin 1	Rattus norvegicus	159-164
30850589-2	2019	Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	55-69	CD274 molecule	Homo sapiens	83-88
30850589-2	2019	Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	55-69	aryl hydrocarbon receptor	Homo sapiens	168-193
30850589-2	2019	Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	55-69	aryl hydrocarbon receptor	Homo sapiens	195-198
30850589-2	2019	Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	71-74	CD274 molecule	Homo sapiens	83-88
30850589-2	2019	Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	71-74	aryl hydrocarbon receptor	Homo sapiens	168-193
30850589-2	2019	Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	71-74	aryl hydrocarbon receptor	Homo sapiens	195-198
30850589-3	2019	Anti-PD-L1 antibody or deficiency in AhR significantly suppresses BaP-induced lung cancer.	Benzo(a)pyrene	66-69	aryl hydrocarbon receptor	Homo sapiens	37-40
31201638-2	2019	Using a human lung cancer cells as a model, we showed that XRE elements in the hybrid promoter greatly increase the activity of the hTERT promoter and ensure the reporter gene transcriptional activation in response to the treatment of the cells with the AhR ligand benzo(a)pyrene.	Benzo(a)pyrene	265-279	telomerase reverse transcriptase	Homo sapiens	132-137
30758933-5	2019	On this coculture model, 2D bP may increase anti-inflammatory cytokine generation (i.e., interleukin-10) and inhibit proinflammatory mediators synthesis (i.e., interleukin-6), thus suggesting the opportunity to prevent cancer-related inflammation.	Benzo(a)pyrene	28-30	interleukin 10	Homo sapiens	89-103
30758933-5	2019	On this coculture model, 2D bP may increase anti-inflammatory cytokine generation (i.e., interleukin-10) and inhibit proinflammatory mediators synthesis (i.e., interleukin-6), thus suggesting the opportunity to prevent cancer-related inflammation.	Benzo(a)pyrene	28-30	interleukin 6	Homo sapiens	160-173
30572064-8	2019	The downregulation and/or inhibition of CYP1 enzymes by PUFAs could thus alter metabolism and reduce genotoxicity of BaP in human colon cells, which might contribute to known chemopreventive effects of PUFAs in colon epithelium.	Benzo(a)pyrene	117-120	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-44
30357576-6	2019	RESULTS: Nuclear SOX9 expression was detected in the epithelial cells of 98% HG IPMN, 93% LG IPMN, 83% PDAC, and 60% BP.	Benzo(a)pyrene	117-119	SRY-box transcription factor 9	Homo sapiens	17-21
30385349-0	2019	Phosphorylation of eIF2alpha promotes cell survival in response to benzo[a]pyrene exposure.	Benzo(a)pyrene	67-81	eukaryotic translation initiation factor 2A	Mus musculus	19-28
30483797-6	2019	CAR/BaP activated the ROS-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)Thr308 signaling pathway, whereas the effectors of the PI3K/AKT signaling pathway, murine double minute 2 (MDM2) and p53Ser15, served important functions in the BaP/CAR-mediated MCF10A cellular transformation.	Benzo(a)pyrene	4-7	thymoma viral proto-oncogene 1	Mus musculus	86-89
30483797-6	2019	CAR/BaP activated the ROS-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)Thr308 signaling pathway, whereas the effectors of the PI3K/AKT signaling pathway, murine double minute 2 (MDM2) and p53Ser15, served important functions in the BaP/CAR-mediated MCF10A cellular transformation.	Benzo(a)pyrene	4-7	thymoma viral proto-oncogene 1	Mus musculus	150-153
30483797-6	2019	CAR/BaP activated the ROS-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)Thr308 signaling pathway, whereas the effectors of the PI3K/AKT signaling pathway, murine double minute 2 (MDM2) and p53Ser15, served important functions in the BaP/CAR-mediated MCF10A cellular transformation.	Benzo(a)pyrene	4-7	transformed mouse 3T3 cell double minute 2	Mus musculus	197-201
30385349-4	2019	Here we investigated the role of phosphorylated eIF2alpha during exposure to the environmental carcinogen benzo(a)pyrene (BaP).	Benzo(a)pyrene	106-120	eukaryotic translation initiation factor 2A	Mus musculus	48-57
30385349-4	2019	Here we investigated the role of phosphorylated eIF2alpha during exposure to the environmental carcinogen benzo(a)pyrene (BaP).	Benzo(a)pyrene	122-125	eukaryotic translation initiation factor 2A	Mus musculus	48-57
30385349-7	2019	Survival of MEF S51A cells is profoundly reduced compared to MEF WT controls after BaP exposure.	Benzo(a)pyrene	83-86	E74-like factor 4 (ets domain transcription factor)	Mus musculus	12-15
30385349-7	2019	Survival of MEF S51A cells is profoundly reduced compared to MEF WT controls after BaP exposure.	Benzo(a)pyrene	83-86	E74-like factor 4 (ets domain transcription factor)	Mus musculus	61-64
30385349-9	2019	Disruption of eIF2alpha phosphorylation caused increased levels of apoptosis in response to BaP.	Benzo(a)pyrene	92-95	eukaryotic translation initiation factor 2A	Mus musculus	14-23
30385349-10	2019	This work demonstrates that eIF2alpha phosphorylation is important for reducing apoptosis and promoting cell survival in order to adapt to BaP exposure.	Benzo(a)pyrene	139-142	eukaryotic translation initiation factor 2A	Mus musculus	28-37
30696442-0	2019	NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.	Benzo(a)pyrene	80-94	NLR family, pyrin domain containing 3	Mus musculus	0-5
30462273-5	2019	To define BP utilization by SF3B1-mutant spliceosomes, we used an overexpression approach in human cells as well as a complementary strategy using isogenic murine embryonic stem cells with monoallelic K700E mutations constructed via CRISPR/Cas9-based genome editing and a dual vector homology-directed repair methodology.	Benzo(a)pyrene	10-12	splicing factor 3b subunit 1	Homo sapiens	28-33
30665459-10	2019	In the mouse model, BaP-induced NTDs were associated with hypermethylation of specific CpG sites within both the promoter and body region of Pax3.	Benzo(a)pyrene	20-23	paired box 3	Mus musculus	141-145
30439556-4	2019	In combination with BaP, butyrate potentiated induction of cytochrome P450 family 1 enzymes (CYP1A1), aldo-keto reductases (AKR1C1) or UDP-glucuronosyltransferases (UGT1A1).	Benzo(a)pyrene	20-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
30439556-8	2019	Butyrate increased induction of enzymatic activities of NATs, NQO1 and UGTs by BaP in HCT-116 and HT29 cells, whereas in differentiated Caco-2 cells it helped to increase only enzymatic activity of NQO1 and UGTs.	Benzo(a)pyrene	79-82	NAD(P)H quinone dehydrogenase 1	Homo sapiens	62-66
31462083-0	2019	Aryl Hydrocarbon Receptor Mediates Cell Proliferation Enhanced by Benzo[a]pyrene in Human Lung Cancer 3D Spheroids.	Benzo(a)pyrene	66-80	aryl hydrocarbon receptor	Homo sapiens	0-25
31462083-1	2019	The aryl hydrocarbon receptor (AhR) is activated by the ligand, benzo[a]pyrene (B[a]P), a component of smoke that is implicated in lung carcinogenesis in humans.	Benzo(a)pyrene	64-78	aryl hydrocarbon receptor	Homo sapiens	4-29
31462083-1	2019	The aryl hydrocarbon receptor (AhR) is activated by the ligand, benzo[a]pyrene (B[a]P), a component of smoke that is implicated in lung carcinogenesis in humans.	Benzo(a)pyrene	64-78	aryl hydrocarbon receptor	Homo sapiens	31-34
31462083-1	2019	The aryl hydrocarbon receptor (AhR) is activated by the ligand, benzo[a]pyrene (B[a]P), a component of smoke that is implicated in lung carcinogenesis in humans.	Benzo(a)pyrene	80-85	aryl hydrocarbon receptor	Homo sapiens	4-29
31462083-1	2019	The aryl hydrocarbon receptor (AhR) is activated by the ligand, benzo[a]pyrene (B[a]P), a component of smoke that is implicated in lung carcinogenesis in humans.	Benzo(a)pyrene	80-85	aryl hydrocarbon receptor	Homo sapiens	31-34
30270567-9	2019	The daily insulin dosage among GLP-1RA/insulin users was 30.3 IU/day (95% CI, -41.2 to -19.3; P &lt; 0.001; I2  = 94%), lower than with BP/BB.	Benzo(a)pyrene	136-138	insulin	Homo sapiens	10-17
30473298-10	2019	MAb-sea bass VTG 41 was specific to VTG from E2-treated sea bass and others EDCs (Nonylphenol, Benzo[a]pyrene and CdCl2).	Benzo(a)pyrene	95-109	vitellogenin-2-like	Lates calcarifer	13-16
30473298-10	2019	MAb-sea bass VTG 41 was specific to VTG from E2-treated sea bass and others EDCs (Nonylphenol, Benzo[a]pyrene and CdCl2).	Benzo(a)pyrene	95-109	vitellogenin-2-like	Lates calcarifer	36-39
31679311-2	2019	Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here.	Benzo(a)pyrene	80-94	prohibitin 2	Mus musculus	96-101
30726812-0	2019	Benzo[a]pyrene induces pyroptotic and autophagic death through inhibiting PI3K/Akt signaling pathway in HL-7702 human normal liver cells.	Benzo(a)pyrene	0-14	AKT serine/threonine kinase 1	Homo sapiens	79-82
31084278-7	2019	Further, there was evidence that elevated PM2.5 and BaP exposure was associated with significantly diminished levels of the serum amyloid A (SAA); however, the false discovery rates (FDRs) were &gt;0.2 after accounting for multiple comparisons.	Benzo(a)pyrene	52-55	serum amyloid A1 cluster	Homo sapiens	124-139
31084278-7	2019	Further, there was evidence that elevated PM2.5 and BaP exposure was associated with significantly diminished levels of the serum amyloid A (SAA); however, the false discovery rates (FDRs) were &gt;0.2 after accounting for multiple comparisons.	Benzo(a)pyrene	52-55	serum amyloid A1 cluster	Homo sapiens	141-144
30189292-6	2019	Strong evidence from pre-clinical animal models and genome-wide association studies indicate that smooth muscle contraction and BP homeostasis are governed by the small GTPase RhoA and its downstream target, Rho kinase.	Benzo(a)pyrene	128-130	ras homolog family member A	Homo sapiens	176-180
30204910-0	2019	Down-Regulation of p23 in Normal Lung Epithelial Cells Reduces Toxicities From Exposure to Benzo[a]pyrene and Cigarette Smoke Condensate via an Aryl Hydrocarbon Receptor-Dependent Mechanism.	Benzo(a)pyrene	91-105	prostaglandin E synthase 3	Homo sapiens	19-22
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	152-166	prostaglandin E synthase 3	Homo sapiens	5-8
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	152-166	aryl hydrocarbon receptor	Homo sapiens	33-36
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	152-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	152-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	206-212
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	242-256	prostaglandin E synthase 3	Homo sapiens	5-8
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	242-256	aryl hydrocarbon receptor	Homo sapiens	33-36
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	242-256	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
30204910-5	2019	This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species.	Benzo(a)pyrene	242-256	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	206-212
30411754-8	2018	Furthermore, BP significantly elevated the levels of IL-22, JAK1 and STAT3, and reduced the level of BAX in NAFLD, while IL-22 silencing prevented BP from restoring the expression of JAK1, STAT3, and BAX.	Benzo(a)pyrene	13-15	signal transducer and activator of transcription 3	Rattus norvegicus	69-74
30411754-8	2018	Furthermore, BP significantly elevated the levels of IL-22, JAK1 and STAT3, and reduced the level of BAX in NAFLD, while IL-22 silencing prevented BP from restoring the expression of JAK1, STAT3, and BAX.	Benzo(a)pyrene	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	101-104
30411754-9	2018	We conclude that IL-22 is vital for the therapeutic effect of BP, and acts via activation of JAK1/STAT3 signaling and inhibition of the apoptosis factor BAX, which makes IL-22 a promising target for therapy of NAFLD.	Benzo(a)pyrene	62-64	interleukin 22	Rattus norvegicus	17-22
30411754-9	2018	We conclude that IL-22 is vital for the therapeutic effect of BP, and acts via activation of JAK1/STAT3 signaling and inhibition of the apoptosis factor BAX, which makes IL-22 a promising target for therapy of NAFLD.	Benzo(a)pyrene	62-64	interleukin 22	Rattus norvegicus	170-175
30189187-7	2018	Further, upon BP treatment, vimentin expressing clones showed an increase in vitro and in vivo transformation efficiency.	Benzo(a)pyrene	14-16	vimentin	Homo sapiens	28-36
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	BCL2 apoptosis regulator	Homo sapiens	191-196
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	MDM2 proto-oncogene	Homo sapiens	198-202
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	tumor protein p53	Homo sapiens	204-207
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	H3 histone pseudogene 16	Homo sapiens	209-212
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	cyclin dependent kinase inhibitor 2A	Homo sapiens	214-217
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	cyclin dependent kinase 4	Homo sapiens	227-231
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	cyclin dependent kinase 2	Homo sapiens	249-253
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	HRas proto-oncogene, GTPase	Homo sapiens	263-268
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	KRAS proto-oncogene, GTPase	Homo sapiens	270-275
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	BRCA1 DNA repair associated	Homo sapiens	277-282
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	87-101	BRCA2 DNA repair associated	Homo sapiens	288-293
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	BCL2 associated X, apoptosis regulator	Homo sapiens	186-189
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	BCL2 apoptosis regulator	Homo sapiens	191-196
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	MDM2 proto-oncogene	Homo sapiens	198-202
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	tumor protein p53	Homo sapiens	204-207
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	H3 histone pseudogene 16	Homo sapiens	209-212
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	cyclin dependent kinase inhibitor 2A	Homo sapiens	214-217
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	cyclin dependent kinase 4	Homo sapiens	227-231
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	cyclin dependent kinase 2	Homo sapiens	249-253
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	HRas proto-oncogene, GTPase	Homo sapiens	263-268
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	KRAS proto-oncogene, GTPase	Homo sapiens	270-275
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	BRCA1 DNA repair associated	Homo sapiens	277-282
28374118-1	2018	In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0.	Benzo(a)pyrene	79-81	BRCA2 DNA repair associated	Homo sapiens	288-293
28374118-4	2018	Diol-epoxides of DBP and BP were found to bind to p53 with tighter interaction than MDM2 and p53-MDM2 complex.	Benzo(a)pyrene	18-20	tumor protein p53	Homo sapiens	50-53
28374118-4	2018	Diol-epoxides of DBP and BP were found to bind to p53 with tighter interaction than MDM2 and p53-MDM2 complex.	Benzo(a)pyrene	18-20	MDM2 proto-oncogene	Homo sapiens	84-88
28374118-4	2018	Diol-epoxides of DBP and BP were found to bind to p53 with tighter interaction than MDM2 and p53-MDM2 complex.	Benzo(a)pyrene	18-20	tumor protein p53	Homo sapiens	93-96
28374118-4	2018	Diol-epoxides of DBP and BP were found to bind to p53 with tighter interaction than MDM2 and p53-MDM2 complex.	Benzo(a)pyrene	18-20	MDM2 proto-oncogene	Homo sapiens	97-101
29482396-1	2018	Benzo[a]pyrene (BaP) can induce developmental and reproductive toxicity; however, the full scope of its immunotoxic effects remains unknown.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
30048737-6	2018	IL-2 production was reduced in response to treatment with well-known immunotoxicants cyclosporin A (CYA), dexamethasone (DEX), azathioprine (AZPR), methotrexate (MOT) and benzo(a)pyrene (BAP) but was not affected by treatment with cyclophosphamide (CYPH).	Benzo(a)pyrene	171-185	interleukin 2	Homo sapiens	0-4
30048737-6	2018	IL-2 production was reduced in response to treatment with well-known immunotoxicants cyclosporin A (CYA), dexamethasone (DEX), azathioprine (AZPR), methotrexate (MOT) and benzo(a)pyrene (BAP) but was not affected by treatment with cyclophosphamide (CYPH).	Benzo(a)pyrene	187-190	interleukin 2	Homo sapiens	0-4
30165701-2	2018	In this study, using Cyp1b1-/-, Cyp1a1/1a2-/-, and Cyp1a1/1a2/1b1-/- mice, we observed that cigarette and environmental toxins, namely benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induce pancreatic mitochondrial respiratory dysfunction and pancreatitis.	Benzo(a)pyrene	135-149	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	21-27
30165701-2	2018	In this study, using Cyp1b1-/-, Cyp1a1/1a2-/-, and Cyp1a1/1a2/1b1-/- mice, we observed that cigarette and environmental toxins, namely benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induce pancreatic mitochondrial respiratory dysfunction and pancreatitis.	Benzo(a)pyrene	135-149	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	32-38
30165701-2	2018	In this study, using Cyp1b1-/-, Cyp1a1/1a2-/-, and Cyp1a1/1a2/1b1-/- mice, we observed that cigarette and environmental toxins, namely benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induce pancreatic mitochondrial respiratory dysfunction and pancreatitis.	Benzo(a)pyrene	135-149	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-57
30165701-6	2018	Interestingly, the AhR antagonist resveratrol, attenuated BaP-induced mitochondrial respiratory defects in the pancreas, and reversed pancreatitis, both histologically and biochemically in wild-type mice.	Benzo(a)pyrene	58-61	aryl-hydrocarbon receptor	Mus musculus	19-22
30165701-9	2018	Resveratrol, a chemo preventive agent and AhR antagonist, and CH-223191, a potent and specific AhR inhibitor, confer protection against BaP-induced mitochondrial dysfunction and pancreatic pathology.	Benzo(a)pyrene	136-139	aryl-hydrocarbon receptor	Mus musculus	95-98
30142607-3	2018	Fluoranthene (Flt) was the most commonly occurring among the 16 priority PAHs, and benzo(a)pyrene (BaP) accounted for the largest portion of the total carcinogenic potency of PAHs in PM2.5.	Benzo(a)pyrene	83-97	prohibitin 2	Homo sapiens	99-102
30053493-9	2018	Moreover, BaP exposure increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcgamma receptor I (FcgammaRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens.	Benzo(a)pyrene	10-13	histocompatibility-2, MHC	Mus musculus	51-92
30411754-3	2018	Here, we investigated whether the anti-inflammatory cytokine, IL-22, was involved in the therapeutic process of BP, using cell and rat models of NAFLD.	Benzo(a)pyrene	112-114	interleukin 22	Rattus norvegicus	62-67
30411754-6	2018	In vivo, the serum parameters and pathological degree of NAFLD rats were significantly improved by BP, while IL-22 silencing significantly abolished the BP effect.	Benzo(a)pyrene	153-155	interleukin 22	Rattus norvegicus	109-114
30411754-8	2018	Furthermore, BP significantly elevated the levels of IL-22, JAK1 and STAT3, and reduced the level of BAX in NAFLD, while IL-22 silencing prevented BP from restoring the expression of JAK1, STAT3, and BAX.	Benzo(a)pyrene	13-15	interleukin 22	Rattus norvegicus	53-58
30411754-8	2018	Furthermore, BP significantly elevated the levels of IL-22, JAK1 and STAT3, and reduced the level of BAX in NAFLD, while IL-22 silencing prevented BP from restoring the expression of JAK1, STAT3, and BAX.	Benzo(a)pyrene	13-15	Janus kinase 1	Rattus norvegicus	60-64
30408084-1	2018	BACKGROUND: Consumption of meat prepared by barbecuing is associated with risk of cancer due to formation of carcinogenic compounds including benzo[a]pyrene (BaP).	Benzo(a)pyrene	142-156	prohibitin 2	Homo sapiens	158-161
30257315-4	2018	In vivo anticancer activity was investigated by evaluating oxidative stress, tumor biomarkers, weight, lung microarchitecture, and Hsp70 and Hsp90 inhibitions via immunoblotting in benzo[a]pyrene induced lung carcinogenesis mice model.	Benzo(a)pyrene	181-195	heat shock protein 1B	Mus musculus	131-136
30257315-4	2018	In vivo anticancer activity was investigated by evaluating oxidative stress, tumor biomarkers, weight, lung microarchitecture, and Hsp70 and Hsp90 inhibitions via immunoblotting in benzo[a]pyrene induced lung carcinogenesis mice model.	Benzo(a)pyrene	181-195	heat shock protein, 3	Mus musculus	141-146
30257315-12	2018	CONCLUSION: MB demonstrated potent anticancer activity in vitro and in vivo via inhibition of Hsp70 in benzo[a]pyrene induced lung carcinogenesis in mice.	Benzo(a)pyrene	103-117	heat shock protein 1B	Mus musculus	94-99
30126007-6	2018	RESULTS: Mice with BP allergy had an increased level of the innate cytokines IL-33, IL-25, GM-CSF and IL-5+ ILC2s in the lungs.	Benzo(a)pyrene	19-21	interleukin 33	Mus musculus	77-82
30126007-6	2018	RESULTS: Mice with BP allergy had an increased level of the innate cytokines IL-33, IL-25, GM-CSF and IL-5+ ILC2s in the lungs.	Benzo(a)pyrene	19-21	interleukin 25	Mus musculus	84-89
30126007-6	2018	RESULTS: Mice with BP allergy had an increased level of the innate cytokines IL-33, IL-25, GM-CSF and IL-5+ ILC2s in the lungs.	Benzo(a)pyrene	19-21	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	91-97
30126007-6	2018	RESULTS: Mice with BP allergy had an increased level of the innate cytokines IL-33, IL-25, GM-CSF and IL-5+ ILC2s in the lungs.	Benzo(a)pyrene	19-21	interleukin 5	Mus musculus	102-106
30225694-5	2018	The aim of this study was to clarify the cytotoxic effects of the extract of actual urban PM1 with high benzo[a]pyrene (BaP) content collected in Eastern European mid-sized city during winter heating season on human bronchial epithelial cells (BEAS-2B).	Benzo(a)pyrene	104-118	transmembrane protein 11	Homo sapiens	90-93
30225694-5	2018	The aim of this study was to clarify the cytotoxic effects of the extract of actual urban PM1 with high benzo[a]pyrene (BaP) content collected in Eastern European mid-sized city during winter heating season on human bronchial epithelial cells (BEAS-2B).	Benzo(a)pyrene	120-123	transmembrane protein 11	Homo sapiens	90-93
30053493-9	2018	Moreover, BaP exposure increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcgamma receptor I (FcgammaRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens.	Benzo(a)pyrene	10-13	histocompatibility-2, MHC	Mus musculus	94-100
30053493-9	2018	Moreover, BaP exposure increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcgamma receptor I (FcgammaRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens.	Benzo(a)pyrene	10-13	CD14 antigen	Mus musculus	103-107
30053493-9	2018	Moreover, BaP exposure increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcgamma receptor I (FcgammaRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens.	Benzo(a)pyrene	10-13	Fc receptor, IgG, high affinity I	Mus musculus	129-138
30053493-9	2018	Moreover, BaP exposure increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcgamma receptor I (FcgammaRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens.	Benzo(a)pyrene	10-13	Fc receptor, IgG, high affinity I	Mus musculus	139-143
30053493-9	2018	Moreover, BaP exposure increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcgamma receptor I (FcgammaRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens.	Benzo(a)pyrene	10-13	CD86 antigen	Mus musculus	149-153
30338975-4	2018	Under the protection of argon (Ar) atmosphere, the direct high-energy mechanical milling of the BP nanoparticle and NTO/C results in the formation of NTO/C-BP hybrids.	Benzo(a)pyrene	96-98	CREB binding protein	Homo sapiens	154-158
30338975-6	2018	The NTO/C-BP hybrids are not only beneficial for enhancing specific capacity but also have a great protective effect on the exposure of BP to air by the synergistic effect between BP and NTO/C.	Benzo(a)pyrene	136-138	CREB binding protein	Homo sapiens	8-12
30417862-2	2018	To overcome this difficulty, we used imaging flow cytometry and transcriptomic profiling (RNA-seq) to determine altered subcellular localization of the cluster of differentiation 1d protein (CD1d) associated with impaired endocytic gene expression in human dendritic cells (DCs), which were exposed to the common lipophilic air pollutant benzo[a]pyrene.	Benzo(a)pyrene	338-352	CD1d molecule	Homo sapiens	191-195
30417862-5	2018	The enhanced CD1d and Lamp1 colocalization upon BaP exposure was further demonstrated using thresholded scatterplots, tested with Mander"s coefficients for co-localized intensity, and plotted based on the percentage of co-localized areas using ImageJ-Fiji.	Benzo(a)pyrene	48-51	CD1d molecule	Homo sapiens	13-17
30417862-5	2018	The enhanced CD1d and Lamp1 colocalization upon BaP exposure was further demonstrated using thresholded scatterplots, tested with Mander"s coefficients for co-localized intensity, and plotted based on the percentage of co-localized areas using ImageJ-Fiji.	Benzo(a)pyrene	48-51	lysosomal associated membrane protein 1	Homo sapiens	22-27
30240956-6	2018	MTT assays in CD44 positive LP-1 multiple myeloma cells revealed that BP encapsulated in HA-CCMs caused enhanced antiproliferative effect compared with free BP.	Benzo(a)pyrene	70-72	CD44 antigen	Mus musculus	14-18
30240956-15	2018	Our results showed that BP-loaded HA-CCMs exhibit markedly enhanced toleration, broadened therapeutic window, and significantly more effective growth suppression of CD44-overexpressed multiple myeloma in nude mice than free bortezomib.	Benzo(a)pyrene	24-26	CD44 antigen	Mus musculus	165-169
30099064-0	2018	Aryl hydrocarbon receptor activation by benzo(a)pyrene inhibits proliferation of myeloid precursor cells and alters the differentiation state as well as the functional phenotype of murine bone marrow-derived macrophages.	Benzo(a)pyrene	40-54	aryl-hydrocarbon receptor	Mus musculus	0-25
30099064-3	2018	Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected.	Benzo(a)pyrene	80-94	aryl-hydrocarbon receptor	Mus musculus	40-43
30099064-3	2018	Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected.	Benzo(a)pyrene	80-94	aryl-hydrocarbon receptor	Mus musculus	69-72
30099064-3	2018	Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected.	Benzo(a)pyrene	96-99	aryl-hydrocarbon receptor	Mus musculus	40-43
30099064-3	2018	Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected.	Benzo(a)pyrene	96-99	aryl-hydrocarbon receptor	Mus musculus	69-72
30099064-5	2018	However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner.	Benzo(a)pyrene	178-181	adhesion G protein-coupled receptor E1	Mus musculus	52-57
30099064-5	2018	However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner.	Benzo(a)pyrene	178-181	histocompatibility-2, MHC	Mus musculus	63-104
30099064-5	2018	However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner.	Benzo(a)pyrene	178-181	histocompatibility-2, MHC	Mus musculus	106-112
30099064-5	2018	However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner.	Benzo(a)pyrene	178-181	Fc receptor, IgG, high affinity I	Mus musculus	142-151
30099064-5	2018	However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner.	Benzo(a)pyrene	178-181	Fc receptor, IgG, high affinity I	Mus musculus	152-156
30099064-5	2018	However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner.	Benzo(a)pyrene	178-181	aryl-hydrocarbon receptor	Mus musculus	201-204
30099064-6	2018	Analysis of cytokine secretion after BMM activation with heat-killed (hk) salmonellae showed that BaP exposure resulted in suppressed secretion of interleukin (IL)-1beta, IL-6 and the chemokine CXC motif ligand 1 (CXCL1).	Benzo(a)pyrene	98-101	interleukin 1 beta	Mus musculus	147-169
30099064-6	2018	Analysis of cytokine secretion after BMM activation with heat-killed (hk) salmonellae showed that BaP exposure resulted in suppressed secretion of interleukin (IL)-1beta, IL-6 and the chemokine CXC motif ligand 1 (CXCL1).	Benzo(a)pyrene	98-101	interleukin 6	Mus musculus	171-175
30099064-6	2018	Analysis of cytokine secretion after BMM activation with heat-killed (hk) salmonellae showed that BaP exposure resulted in suppressed secretion of interleukin (IL)-1beta, IL-6 and the chemokine CXC motif ligand 1 (CXCL1).	Benzo(a)pyrene	98-101	chemokine (C-X-C motif) ligand 1	Mus musculus	194-212
30099064-6	2018	Analysis of cytokine secretion after BMM activation with heat-killed (hk) salmonellae showed that BaP exposure resulted in suppressed secretion of interleukin (IL)-1beta, IL-6 and the chemokine CXC motif ligand 1 (CXCL1).	Benzo(a)pyrene	98-101	chemokine (C-X-C motif) ligand 1	Mus musculus	214-219
30099064-7	2018	In contrast, the release of tumor necrosis factor (TNF)-alpha and IL-10 was increased following BaP exposure.	Benzo(a)pyrene	96-99	tumor necrosis factor	Mus musculus	28-61
30099064-7	2018	In contrast, the release of tumor necrosis factor (TNF)-alpha and IL-10 was increased following BaP exposure.	Benzo(a)pyrene	96-99	interleukin 10	Mus musculus	66-71
30099064-9	2018	Bacterial stimulation of BaP exposed BMMs also induced the expression of MHC-II and CD64, while the expression of F4/80 was dramatically decreased.	Benzo(a)pyrene	25-28	histocompatibility-2, MHC	Mus musculus	73-79
30099064-9	2018	Bacterial stimulation of BaP exposed BMMs also induced the expression of MHC-II and CD64, while the expression of F4/80 was dramatically decreased.	Benzo(a)pyrene	25-28	Fc receptor, IgG, high affinity I	Mus musculus	84-88
30099064-9	2018	Bacterial stimulation of BaP exposed BMMs also induced the expression of MHC-II and CD64, while the expression of F4/80 was dramatically decreased.	Benzo(a)pyrene	25-28	adhesion G protein-coupled receptor E1	Mus musculus	114-119
30031117-4	2018	We showed that tobacco carcinogen benzo(a)pyrene (BaP) induced upregulation of IRX5 in lung epithelial cells, and Cyclin D1 was a downstream target of IRX5.	Benzo(a)pyrene	34-48	Iroquois homeobox 5	Mus musculus	79-83
30031117-4	2018	We showed that tobacco carcinogen benzo(a)pyrene (BaP) induced upregulation of IRX5 in lung epithelial cells, and Cyclin D1 was a downstream target of IRX5.	Benzo(a)pyrene	34-48	Iroquois homeobox 5	Mus musculus	151-155
30031117-4	2018	We showed that tobacco carcinogen benzo(a)pyrene (BaP) induced upregulation of IRX5 in lung epithelial cells, and Cyclin D1 was a downstream target of IRX5.	Benzo(a)pyrene	50-53	Iroquois homeobox 5	Mus musculus	79-83
30031117-4	2018	We showed that tobacco carcinogen benzo(a)pyrene (BaP) induced upregulation of IRX5 in lung epithelial cells, and Cyclin D1 was a downstream target of IRX5.	Benzo(a)pyrene	50-53	Iroquois homeobox 5	Mus musculus	151-155
30155724-1	2018	Benzo[a]pyrene (B(a)P) is a major cancer-causing contaminant present in food such as cooked meats and cereals, and is ubiquitous in the environment in smoke derived from the combustion of organic material.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-21
29758891-1	2018	The involvement of benzo[a]pyrene (BaP) one of the most toxic polycyclic aromatic hydrocarbons (PAHs) in the soil-plant system causes its potential carcinogenicity and mutagenicity for human health.	Benzo(a)pyrene	19-33	prohibitin 2	Homo sapiens	35-38
30053493-0	2018	Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner.	Benzo(a)pyrene	0-14	interleukin 10	Mus musculus	127-132
30053493-0	2018	Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	150-175
30053493-2	2018	Most effects of BaP towards immune cells are thought to be mediated through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	16-19	aryl-hydrocarbon receptor	Mus musculus	94-119
30053493-2	2018	Most effects of BaP towards immune cells are thought to be mediated through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	16-19	aryl-hydrocarbon receptor	Mus musculus	121-124
29981922-2	2018	Our previous findings suggested that knockdown of PARG attenuates benzo(a)pyrene (BaP) carcinogenesis.	Benzo(a)pyrene	66-80	poly(ADP-ribose) glycohydrolase	Homo sapiens	50-54
29981922-2	2018	Our previous findings suggested that knockdown of PARG attenuates benzo(a)pyrene (BaP) carcinogenesis.	Benzo(a)pyrene	82-85	poly(ADP-ribose) glycohydrolase	Homo sapiens	50-54
29981922-8	2018	H2AK5ac, H2AK9ac, H2AK13ac, H2A.ZK4K7K11ac, and H2AK9me were expressed in BaP-transformed 16HBE (BTC-16HBE) cells, but were not detectable in normal 16HBE or BaP-transformed 16HBE cells with knockdown of PARG (BTC-shPARG).	Benzo(a)pyrene	74-77	poly(ADP-ribose) glycohydrolase	Homo sapiens	204-208
29981922-10	2018	These findings suggest that knockdown of PARG protects against BaP-induced carcinogenesis in 16HBE cells by downregulating H2AK9me.	Benzo(a)pyrene	63-66	poly(ADP-ribose) glycohydrolase	Homo sapiens	41-45
29981922-11	2018	Our in vivo studies confirmed that PARG silencing decreased H2AK9me levels, thereby countering the carcinogenic teratogenic effects induced by BaP.	Benzo(a)pyrene	143-146	poly(ADP-ribose) glycohydrolase	Homo sapiens	35-39
30137621-3	2018	Here, we analyzed the impact of AhR on estrogen-like effects of PAHs, such as benzo[a]pyrene (BaP), in particular, on control of cell cycle progression/cell proliferation.	Benzo(a)pyrene	94-97	aryl hydrocarbon receptor	Homo sapiens	32-35
30137621-4	2018	Using AhR knockout variant of estrogen-sensitive human breast cancer MCF-7 cells (MCF-7 AhRKO cells), we observed that the AhR-dependent control of cytochrome P450 family 1 (CYP1) expression played a major role in formation of estrogenic BaP metabolites, most notably 3-OH-BaP, which contributed to the ER-dependent induction of cell cycle progression/cell proliferation.	Benzo(a)pyrene	238-241	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	148-172
30137621-4	2018	Using AhR knockout variant of estrogen-sensitive human breast cancer MCF-7 cells (MCF-7 AhRKO cells), we observed that the AhR-dependent control of cytochrome P450 family 1 (CYP1) expression played a major role in formation of estrogenic BaP metabolites, most notably 3-OH-BaP, which contributed to the ER-dependent induction of cell cycle progression/cell proliferation.	Benzo(a)pyrene	238-241	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	174-178
30137621-8	2018	Ectopic expression of human CYP1A1 and CYP1B1 enzymes partly restored both BaP metabolism and its effects on cell proliferation.	Benzo(a)pyrene	75-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34
30137621-8	2018	Ectopic expression of human CYP1A1 and CYP1B1 enzymes partly restored both BaP metabolism and its effects on cell proliferation.	Benzo(a)pyrene	75-78	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45
29746904-0	2018	Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF.	Benzo(a)pyrene	0-14	TGFB induced factor homeobox 1	Homo sapiens	104-108
29746904-1	2018	This study aimed to investigate the potential roles of TG-interacting factor (TGIF) in benzo(a)pyrene (BaP)-induced migration, invasion, and metastasis of lung adenocarcinoma cells.	Benzo(a)pyrene	87-101	TGFB induced factor homeobox 1	Homo sapiens	55-76
29746904-1	2018	This study aimed to investigate the potential roles of TG-interacting factor (TGIF) in benzo(a)pyrene (BaP)-induced migration, invasion, and metastasis of lung adenocarcinoma cells.	Benzo(a)pyrene	87-101	TGFB induced factor homeobox 1	Homo sapiens	78-82
29746904-1	2018	This study aimed to investigate the potential roles of TG-interacting factor (TGIF) in benzo(a)pyrene (BaP)-induced migration, invasion, and metastasis of lung adenocarcinoma cells.	Benzo(a)pyrene	103-106	TGFB induced factor homeobox 1	Homo sapiens	55-76
29746904-1	2018	This study aimed to investigate the potential roles of TG-interacting factor (TGIF) in benzo(a)pyrene (BaP)-induced migration, invasion, and metastasis of lung adenocarcinoma cells.	Benzo(a)pyrene	103-106	TGFB induced factor homeobox 1	Homo sapiens	78-82
29746904-5	2018	A dual-luciferase reporter gene assay was performed to assess the effects of BaP on TGIF promoter-driven reporter gene expression.	Benzo(a)pyrene	77-80	TGFB induced factor homeobox 1	Homo sapiens	84-88
29746904-7	2018	Our results showed that BaP treatment increased the expression of TGIF mRNA and protein.	Benzo(a)pyrene	24-27	TGFB induced factor homeobox 1	Homo sapiens	66-70
29746904-8	2018	Additionally, BaP treatment enhanced TGIF promoter-driven reporter gene expression.	Benzo(a)pyrene	14-17	TGFB induced factor homeobox 1	Homo sapiens	37-41
29746904-9	2018	We observed that BaP treatment promoted the migration, invasion, and metastasis of H157 cells, which could be blocked by silencing TGIF.	Benzo(a)pyrene	17-20	TGFB induced factor homeobox 1	Homo sapiens	131-135
29746904-11	2018	Our findings suggest that BaP treatment promotes the migration, invasion, and metastasis of human lung adenocarcinoma cells by upregulating TGIF.	Benzo(a)pyrene	26-29	TGFB induced factor homeobox 1	Homo sapiens	140-144
30122317-11	2018	Our data also demonstrated that Benzo(a)pyrene (BaP) induced up to 100 folds of mRNA expression of CYP1A1 or CYP1A2 in CR-HNBE cells.	Benzo(a)pyrene	32-46	prohibitin 2	Homo sapiens	48-51
30122317-11	2018	Our data also demonstrated that Benzo(a)pyrene (BaP) induced up to 100 folds of mRNA expression of CYP1A1 or CYP1A2 in CR-HNBE cells.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-105
30122317-11	2018	Our data also demonstrated that Benzo(a)pyrene (BaP) induced up to 100 folds of mRNA expression of CYP1A1 or CYP1A2 in CR-HNBE cells.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
29772428-0	2018	LncRNA H19 interacts with S-adenosylhomocysteine hydrolase to regulate LINE-1 Methylation in human lung-derived cells exposed to Benzo[a]pyrene.	Benzo(a)pyrene	129-143	H19 imprinted maternally expressed transcript	Homo sapiens	7-10
29772428-2	2018	Here, we used three types of human lung-derived cells with BaP exposure as a model and attempted to investigate the long non-coding RNA (lncRNA) H19/S-adenosylhomocysteine hydrolase (SAHH) pathway that regulates gene methylation in vitro exposure to BaP.	Benzo(a)pyrene	250-253	adenosylhomocysteinase	Homo sapiens	145-181
29772428-2	2018	Here, we used three types of human lung-derived cells with BaP exposure as a model and attempted to investigate the long non-coding RNA (lncRNA) H19/S-adenosylhomocysteine hydrolase (SAHH) pathway that regulates gene methylation in vitro exposure to BaP.	Benzo(a)pyrene	250-253	adenosylhomocysteinase	Homo sapiens	183-187
29772428-3	2018	Results showed that compared to the controls, BaP-treated cells H19 expressions were increased in a dose- and time-dependent manner, whereas SAHH protein expressions were decreased.	Benzo(a)pyrene	46-49	H19 imprinted maternally expressed transcript	Homo sapiens	64-67
29753248-6	2018	The methylation levels of the gonadotropin releasing hormone (GnRH) gene gnrh3 were significantly increased in the adult zebrafish brain, and those of the GnRH receptor gene gnrhr3 were elevated both in the larvae exposed to BaP and in the adult brain, which might cause the down-regulation of the mRNA levels of gnrh3 and gnrhr3.	Benzo(a)pyrene	225-228	gonadotropin-releasing hormone 3	Danio rerio	73-78
29753248-6	2018	The methylation levels of the gonadotropin releasing hormone (GnRH) gene gnrh3 were significantly increased in the adult zebrafish brain, and those of the GnRH receptor gene gnrhr3 were elevated both in the larvae exposed to BaP and in the adult brain, which might cause the down-regulation of the mRNA levels of gnrh3 and gnrhr3.	Benzo(a)pyrene	225-228	gonadotropin releasing hormone receptor 3	Danio rerio	174-180
30006417-7	2018	CONCLUSIONS: Intensive BP lowering was associated with a mortality benefit only if declines in eGFR were &lt;20%.	Benzo(a)pyrene	23-25	epidermal growth factor receptor	Homo sapiens	95-99
30243371-0	2018	Benzo(a)pyrene suppresses tracheal antimicrobial peptide gene expression in bovine tracheal epithelial cells.	Benzo(a)pyrene	0-14	tracheal antimicrobial peptide	Bos taurus	26-56
30243371-5	2018	This hypothesis was modeled by measuring the in vitro effects of benzo(a)pyrene (BAP), phenanthrene, and naphthalene on tracheal antimicrobial peptide (TAP) gene expression in bovine tracheal epithelial cells.	Benzo(a)pyrene	65-79	tracheal antimicrobial peptide	Bos taurus	120-150
30243371-5	2018	This hypothesis was modeled by measuring the in vitro effects of benzo(a)pyrene (BAP), phenanthrene, and naphthalene on tracheal antimicrobial peptide (TAP) gene expression in bovine tracheal epithelial cells.	Benzo(a)pyrene	65-79	tracheal antimicrobial peptide	Bos taurus	152-155
30243371-5	2018	This hypothesis was modeled by measuring the in vitro effects of benzo(a)pyrene (BAP), phenanthrene, and naphthalene on tracheal antimicrobial peptide (TAP) gene expression in bovine tracheal epithelial cells.	Benzo(a)pyrene	81-84	tracheal antimicrobial peptide	Bos taurus	120-150
30243371-5	2018	This hypothesis was modeled by measuring the in vitro effects of benzo(a)pyrene (BAP), phenanthrene, and naphthalene on tracheal antimicrobial peptide (TAP) gene expression in bovine tracheal epithelial cells.	Benzo(a)pyrene	81-84	tracheal antimicrobial peptide	Bos taurus	152-155
30243371-7	2018	Exposure of tracheal epithelial cells to 5 muM BAP for 4 or 8 h, followed by incubation with a combination of LPS and 5 muM BAP for another 16 h, significantly (P = 0.002) suppressed LPS-induced TAP gene expression by 40.6 +- 21.8% (mean +- SD) in tracheal epithelial cells from 9 calves tested.	Benzo(a)pyrene	47-50	tracheal antimicrobial peptide	Bos taurus	195-198
30243371-7	2018	Exposure of tracheal epithelial cells to 5 muM BAP for 4 or 8 h, followed by incubation with a combination of LPS and 5 muM BAP for another 16 h, significantly (P = 0.002) suppressed LPS-induced TAP gene expression by 40.6 +- 21.8% (mean +- SD) in tracheal epithelial cells from 9 calves tested.	Benzo(a)pyrene	124-127	tracheal antimicrobial peptide	Bos taurus	195-198
30243371-8	2018	BAP-induced suppression of TAP gene expression coincided with induction of cytochrome P450 1A1 gene expression.	Benzo(a)pyrene	0-3	tracheal antimicrobial peptide	Bos taurus	27-30
29758891-2	2018	The aim of this article is benzo[a]pyrene (BaP) degradation and bioaccumulation in soil-plant system under artificial contamination in model experiment with Haplic Chernozem and that spiked with various doses of BaP (20, 200, 400 and 800mugkg-1) equivalent to 1, 10, 20 and 40 levels of maximal permissible concentrations (MPC) planted with spring barley (Hordeum sativum distichum).	Benzo(a)pyrene	27-41	prohibitin 2	Homo sapiens	43-46
31458985-1	2018	Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis.	Benzo(a)pyrene	114-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-24
31458985-1	2018	Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis.	Benzo(a)pyrene	114-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-30
29329694-8	2018	Novel vasopressor agents, such as synthetic human angiotensin II, can increase BP and reduce the need for high doses of catecholamine vasopressors in severe or refractory vasodilatory shock.	Benzo(a)pyrene	79-81	angiotensinogen	Homo sapiens	50-64
29921510-0	2018	The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.	Benzo(a)pyrene	45-59	aryl hydrocarbon receptor	Homo sapiens	28-31
29921510-0	2018	The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.	Benzo(a)pyrene	45-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-67
29442200-8	2018	The toxic equivalency factor (TEF) approach indicated that benzo[a]pyrene and benz[a]anthracene were the principal responsible for carcinogenic power of samples.	Benzo(a)pyrene	59-73	TEF transcription factor, PAR bZIP family member	Homo sapiens	4-28
29442200-8	2018	The toxic equivalency factor (TEF) approach indicated that benzo[a]pyrene and benz[a]anthracene were the principal responsible for carcinogenic power of samples.	Benzo(a)pyrene	59-73	TEF transcription factor, PAR bZIP family member	Homo sapiens	30-33
29578247-5	2018	Treatment with 10 mum BaP increased apoptosis, intracellular Ca2+ level ([Ca2+ ]i ) and calmodulin (CaM) protein expression, and decreased the protein level of connexin 43 (Cx43) (also known as gap junction alpha-1 protein [GJA1]) in TM4 cells.	Benzo(a)pyrene	22-25	gap junction protein, alpha 1	Mus musculus	160-171
29578247-5	2018	Treatment with 10 mum BaP increased apoptosis, intracellular Ca2+ level ([Ca2+ ]i ) and calmodulin (CaM) protein expression, and decreased the protein level of connexin 43 (Cx43) (also known as gap junction alpha-1 protein [GJA1]) in TM4 cells.	Benzo(a)pyrene	22-25	gap junction protein, alpha 1	Mus musculus	173-177
29578247-5	2018	Treatment with 10 mum BaP increased apoptosis, intracellular Ca2+ level ([Ca2+ ]i ) and calmodulin (CaM) protein expression, and decreased the protein level of connexin 43 (Cx43) (also known as gap junction alpha-1 protein [GJA1]) in TM4 cells.	Benzo(a)pyrene	22-25	gap junction protein, alpha 1	Mus musculus	194-222
29632030-7	2018	When pregnant women with PIH are identified then the healthcare professional initiates a closer supervision of their pregnancy in order to ameliorate the status of BP and provide a good intrauterine environment for the fetus.	Benzo(a)pyrene	164-166	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	25-28
29704546-4	2018	Importantly, TCDD-like expression fingerprint of selected genes was observed also in A549 cells exposed acutely to both toxic (benzo[a]pyrene, benzo[k]fluoranthene) and endogenous AhR ligands (2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester and 6-formylindolo[3,2-b]carbazole).	Benzo(a)pyrene	127-141	aryl hydrocarbon receptor	Homo sapiens	180-183
29800640-2	2018	We previously showed that Gclm-/- embryos have increased sensitivity to the prenatal in vivo ovarian toxicity of the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) compared with Gclm+/+ littermates.	Benzo(a)pyrene	165-168	glutamate-cysteine ligase, modifier subunit	Mus musculus	26-30
29800640-7	2018	Within each genotype, DMSO and BaP-treated groups had increased germ cell caspase-3 activation compared to uncultured.	Benzo(a)pyrene	31-34	caspase 3	Mus musculus	74-83
29800640-8	2018	Gclm+/- ovaries had significantly increased caspase-3 activation with BaP treatment compared to DMSO, and caspase-3 activation increased non-significantly in Gclm-/- ovaries treated with BaP compared to DMSO.	Benzo(a)pyrene	70-73	glutamate-cysteine ligase, modifier subunit	Mus musculus	0-4
29800640-8	2018	Gclm+/- ovaries had significantly increased caspase-3 activation with BaP treatment compared to DMSO, and caspase-3 activation increased non-significantly in Gclm-/- ovaries treated with BaP compared to DMSO.	Benzo(a)pyrene	70-73	caspase 3	Mus musculus	44-53
29800640-8	2018	Gclm+/- ovaries had significantly increased caspase-3 activation with BaP treatment compared to DMSO, and caspase-3 activation increased non-significantly in Gclm-/- ovaries treated with BaP compared to DMSO.	Benzo(a)pyrene	187-190	caspase 3	Mus musculus	106-115
29800640-8	2018	Gclm+/- ovaries had significantly increased caspase-3 activation with BaP treatment compared to DMSO, and caspase-3 activation increased non-significantly in Gclm-/- ovaries treated with BaP compared to DMSO.	Benzo(a)pyrene	187-190	glutamate-cysteine ligase, modifier subunit	Mus musculus	158-162
29800640-11	2018	These data indicate that Gclm heterozygous or homozygous deletion sensitizes embryonic ovaries to BaP- and tissue culture-induced germ cell apoptosis.	Benzo(a)pyrene	98-101	glutamate-cysteine ligase, modifier subunit	Mus musculus	25-29
29682739-14	2018	CONCLUSIONS: Patients with DPP-4 inhibitor-induced BP may present either an inflammatory or a noninflammatory phenotype of BP.	Benzo(a)pyrene	51-53	dipeptidyl peptidase 4	Homo sapiens	27-32
29991690-8	2018	Further, we observed a nuclear translocation of NF-kappaB subunits (p50 and p65) after chronic BaP exposure, which was reduced by treatment with siRNA and antioxidants/CYP inhibitors.	Benzo(a)pyrene	95-98	nuclear factor kappa B subunit 1	Homo sapiens	68-71
29991690-8	2018	Further, we observed a nuclear translocation of NF-kappaB subunits (p50 and p65) after chronic BaP exposure, which was reduced by treatment with siRNA and antioxidants/CYP inhibitors.	Benzo(a)pyrene	95-98	RELA proto-oncogene, NF-kB subunit	Homo sapiens	76-79
30094095-0	2018	Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.	Benzo(a)pyrene	39-55	aryl hydrocarbon receptor	Homo sapiens	0-25
30094095-0	2018	Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.	Benzo(a)pyrene	39-55	helicase, lymphoid specific	Homo sapiens	65-72
29728975-0	2018	Benzo(a)pyrene parallel measurements in PM1 and PM2.5 in the coastal zone of the Gulf of Gdansk (Baltic Sea) in the heating and non-heating seasons.	Benzo(a)pyrene	0-14	transmembrane protein 11	Homo sapiens	40-43
29728975-3	2018	The average annual concentration of benzo(a)pyrene (B(a)P) was equal to 2.6 ng m-3 in PM1 and 4.6 ng m-3 in PM2.5, and both values were several times higher than the level of 1 ng m-3 which was set out in the CAFE Directive.	Benzo(a)pyrene	36-50	transmembrane protein 11	Homo sapiens	86-89
29728975-3	2018	The average annual concentration of benzo(a)pyrene (B(a)P) was equal to 2.6 ng m-3 in PM1 and 4.6 ng m-3 in PM2.5, and both values were several times higher than the level of 1 ng m-3 which was set out in the CAFE Directive.	Benzo(a)pyrene	52-57	transmembrane protein 11	Homo sapiens	86-89
29682739-14	2018	CONCLUSIONS: Patients with DPP-4 inhibitor-induced BP may present either an inflammatory or a noninflammatory phenotype of BP.	Benzo(a)pyrene	123-125	dipeptidyl peptidase 4	Homo sapiens	27-32
29682739-15	2018	IgG response against other BP180 regions different from the NC16A domain, such as LAD-1 and the C-terminal domain, could be pathogenically relevant to the onset of DPP-4 inhibitor-induced BP.	Benzo(a)pyrene	27-29	ladinin 1	Homo sapiens	82-87
29682739-15	2018	IgG response against other BP180 regions different from the NC16A domain, such as LAD-1 and the C-terminal domain, could be pathogenically relevant to the onset of DPP-4 inhibitor-induced BP.	Benzo(a)pyrene	27-29	dipeptidyl peptidase 4	Homo sapiens	164-169
29749523-0	2018	Overexpression of Annexin A1 protects against benzo[a]pyrene-induced bronchial epithelium injury.	Benzo(a)pyrene	46-60	annexin A1	Homo sapiens	18-28
29749523-9	2018	The results demonstrated that ANXA1 improved the viability of benzo[a]pyrene (Bap)-treated bronchial epithelial cells.	Benzo(a)pyrene	62-76	annexin A1	Homo sapiens	30-35
29749523-9	2018	The results demonstrated that ANXA1 improved the viability of benzo[a]pyrene (Bap)-treated bronchial epithelial cells.	Benzo(a)pyrene	62-76	prohibitin 2	Homo sapiens	78-81
29802988-6	2018	Western blotting showed reduced EPHA2 expression and S897-phosphorylation with PB; RSK phosphorylation was largely unaffected by PB but increased significantly with BP.	Benzo(a)pyrene	165-167	ribosomal protein S6 kinase A2	Homo sapiens	83-86
29458109-2	2018	CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
29930405-1	2018	OBJECTIVE: To investigate effects of benzo(a)pyrene (BaP) on expressions of insulin-degrading enzyme (IDE) and neprilysin (NEP) which have the ability to degrade beta-amyloid (Abeta) in neuroglia cells.	Benzo(a)pyrene	53-56	insulin degrading enzyme	Rattus norvegicus	76-100
29930405-1	2018	OBJECTIVE: To investigate effects of benzo(a)pyrene (BaP) on expressions of insulin-degrading enzyme (IDE) and neprilysin (NEP) which have the ability to degrade beta-amyloid (Abeta) in neuroglia cells.	Benzo(a)pyrene	53-56	insulin degrading enzyme	Rattus norvegicus	102-105
29930405-1	2018	OBJECTIVE: To investigate effects of benzo(a)pyrene (BaP) on expressions of insulin-degrading enzyme (IDE) and neprilysin (NEP) which have the ability to degrade beta-amyloid (Abeta) in neuroglia cells.	Benzo(a)pyrene	53-56	membrane metallo-endopeptidase	Rattus norvegicus	111-121
29930405-1	2018	OBJECTIVE: To investigate effects of benzo(a)pyrene (BaP) on expressions of insulin-degrading enzyme (IDE) and neprilysin (NEP) which have the ability to degrade beta-amyloid (Abeta) in neuroglia cells.	Benzo(a)pyrene	53-56	membrane metallo-endopeptidase	Rattus norvegicus	123-126
29930405-8	2018	CONCLUSION: On the premise of no significant change of cell survival rate, BaP pretreatment inhibited the up-regulated expressions of IDE in primary mixed neuroglia cells under cotreatment with Abeta oligomer, indicating that BaP may disturb degradation of Abeta oligomer and cause deposition of beta-amyloid and further induce cognitive decline and acceleration of Alzheimer.	Benzo(a)pyrene	75-78	insulin degrading enzyme	Rattus norvegicus	134-137
29571093-1	2018	The fate of benzo(a)pyrene (BaP), a ubiquitous contaminant reported to be persistent in the environment, is largely controlled by its interactions with the soil organic matter.	Benzo(a)pyrene	12-26	prohibitin 2	Homo sapiens	28-31
29421756-5	2018	Concentrations of NO3- also increased in soils treated with OS, OS + BC, and OS + BP as result of the increased chitinase and leucine aminopeptidase activities.	Benzo(a)pyrene	82-84	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
28681665-5	2018	Curcumin and quercetin when administered individually as well as in combination significantly elevated the expression of acetylated-p53, which was otherwise depressed due to BP treatment.	Benzo(a)pyrene	174-176	transformation related protein 53, pseudogene	Mus musculus	132-135
28681665-6	2018	Also, both the phytochemicals significantly reduced the BP-inflicted increased levels of phosphorylated-p53.	Benzo(a)pyrene	56-58	transformation related protein 53, pseudogene	Mus musculus	104-107
28527150-5	2018	Like DBP, BP (-10.13 kcal/mol, Ki: 0.04 microM) and BP-diols (BPD) (-9.01 kcal/mol, Ki: 0.25 microM) observed plausible binding with CYP1A1 supporting to the reported data that emphasize the major contribution of CYP1A1 in the activation of similar procarcinogens and mutagens.	Benzo(a)pyrene	6-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
28527150-5	2018	Like DBP, BP (-10.13 kcal/mol, Ki: 0.04 microM) and BP-diols (BPD) (-9.01 kcal/mol, Ki: 0.25 microM) observed plausible binding with CYP1A1 supporting to the reported data that emphasize the major contribution of CYP1A1 in the activation of similar procarcinogens and mutagens.	Benzo(a)pyrene	6-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	213-219
28527150-9	2018	Further, molecular dynamics (MD) simulation of 10 ns has been revealed that docked complexes of CYP1A1 with DBP, DMBA and BP are comparatively more stable than the complex of PhIP.	Benzo(a)pyrene	109-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
29389742-9	2018	Future clinical trials are warranted to test BP-lowering effects in acute ischemic stroke patients by baseline SBP levels.	Benzo(a)pyrene	45-47	selenium binding protein 1	Homo sapiens	111-114
29805565-0	2018	Benzo(a)pyrene promotes Hep-G2 cell migration and invasion by upregulating phosphorylated extracellular signal-regulated kinase expression.	Benzo(a)pyrene	0-14	DNL-type zinc finger	Homo sapiens	24-27
29805565-0	2018	Benzo(a)pyrene promotes Hep-G2 cell migration and invasion by upregulating phosphorylated extracellular signal-regulated kinase expression.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	90-127
29805565-1	2018	Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	97-134
29805565-1	2018	Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	136-139
29805565-1	2018	Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells.	Benzo(a)pyrene	16-19	mitogen-activated protein kinase 1	Homo sapiens	97-134
29805565-1	2018	Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells.	Benzo(a)pyrene	16-19	mitogen-activated protein kinase 1	Homo sapiens	136-139
29805565-3	2018	Therefore, the aim of the present study was to investigate the potential role of phosphorylated (p)-ERK in BaP-induced Hep-G2 cell migration and invasion.	Benzo(a)pyrene	107-110	mitogen-activated protein kinase 1	Homo sapiens	100-103
29805565-3	2018	Therefore, the aim of the present study was to investigate the potential role of phosphorylated (p)-ERK in BaP-induced Hep-G2 cell migration and invasion.	Benzo(a)pyrene	107-110	DNL-type zinc finger	Homo sapiens	119-122
29805565-4	2018	An MTT assay was used to determine the effects of BaP treatment on Hep-G2 cell proliferation.	Benzo(a)pyrene	50-53	DNL-type zinc finger	Homo sapiens	67-70
29805565-7	2018	The results of the present study demonstrated that BaP treatment was able to increase the level of p-ERK protein expression in Hep-G2 cells.	Benzo(a)pyrene	51-54	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	99-104
29805565-7	2018	The results of the present study demonstrated that BaP treatment was able to increase the level of p-ERK protein expression in Hep-G2 cells.	Benzo(a)pyrene	51-54	DNL-type zinc finger	Homo sapiens	127-130
29805565-8	2018	BaP treatment promoted Hep-G2 cell migration and invasion.	Benzo(a)pyrene	0-3	DNL-type zinc finger	Homo sapiens	23-26
29805565-9	2018	The ERK inhibitor, U0126, was able to block the migration and invasion abilities of Hep-G2 cells induced by BaP.	Benzo(a)pyrene	108-111	mitogen-activated protein kinase 1	Homo sapiens	4-7
29805565-9	2018	The ERK inhibitor, U0126, was able to block the migration and invasion abilities of Hep-G2 cells induced by BaP.	Benzo(a)pyrene	108-111	DNL-type zinc finger	Homo sapiens	84-87
29805565-10	2018	The results of the present study demonstrated that BaP treatment promoted the migration and invasion of Hep-G2 cells by upregulating p-ERK expression.	Benzo(a)pyrene	51-54	DNL-type zinc finger	Homo sapiens	104-107
29805565-10	2018	The results of the present study demonstrated that BaP treatment promoted the migration and invasion of Hep-G2 cells by upregulating p-ERK expression.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 1	Homo sapiens	135-138
29545172-0	2018	Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	28-31
29545172-0	2018	Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells.	Benzo(a)pyrene	0-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-35
29545172-0	2018	Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	36-39
29545172-0	2018	Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	65-71
29686083-3	2018	Female Xenopus tropicalis exposed from tadpole stage to benzo(a)pyrene or triclosan at concentrations of 50 ng L-1 displayed glucose intolerance syndrome, liver steatosis, liver mitochondrial dysfunction, liver transcriptomic signature, and pancreatic insulin hypersecretion, all typical of a prediabetes state.	Benzo(a)pyrene	56-70	ribosomal protein L4	Xenopus tropicalis	111-114
29725048-2	2018	Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism.	Benzo(a)pyrene	77-91	glycine N-methyltransferase	Mus musculus	0-27
29725048-2	2018	Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism.	Benzo(a)pyrene	77-91	glycine N-methyltransferase	Mus musculus	29-33
29738693-8	2018	Additionally, compared with siRNA-transfected and benzo[a]pyrene (BaP)-OA-induced HepG2 cells, overexpression of CYP1A1 by BaP further accelerated the lipid peroxidation in OA-treated HepG2 cells.	Benzo(a)pyrene	50-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
29602832-1	2018	Background With No Lysine kinase (WNK) signaling regulates mammalian renal epithelial ion transport to maintain electrolyte and BP homeostasis.	Benzo(a)pyrene	128-130	Wnk kinase	Drosophila melanogaster	34-37
29649501-0	2018	Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats.	Benzo(a)pyrene	128-142	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	83-102
29649501-2	2018	The synthetic estrogen 17alpha-ethinylestradiol (EE2) and the environmental carcinogen benzo[a]pyrene (BaP) are exogenous EDs whereas the estrogenic hormone 17beta-estradiol is a natural endogenous ED.	Benzo(a)pyrene	87-101	prohibitin 2	Rattus norvegicus	103-106
29671487-0	2018	Screening and Management of High BP in Children and Adolescents: An Updated Guideline from the AAP.	Benzo(a)pyrene	33-35	serpin family F member 2	Homo sapiens	95-98
29455995-5	2018	Then, the modified starch was applied to solubilize benzo[a]pyrene (BaP) in view of degradation by Fenton process.	Benzo(a)pyrene	52-66	prohibitin 2	Homo sapiens	68-71
29524502-0	2018	Combined treatment with benzo[a]pyrene and 1alpha,25-dihydroxyvitamin D3 induces expression of plasminogen activator inhibitor 1 in monocyte/macrophage-derived cells.	Benzo(a)pyrene	24-38	serpin family E member 1	Homo sapiens	95-128
29524502-4	2018	We further investigated the cross-talk between BaP and 1,25(OH)2D3 signaling pathways, and found that combined treatment with these compounds induces mRNA and protein expression of plasminogen activator inhibitor 1 (PAI-1) in monocyte/macrophage-derived THP-1 and U937 cells.	Benzo(a)pyrene	47-50	serpin family E member 1	Homo sapiens	181-214
29524502-4	2018	We further investigated the cross-talk between BaP and 1,25(OH)2D3 signaling pathways, and found that combined treatment with these compounds induces mRNA and protein expression of plasminogen activator inhibitor 1 (PAI-1) in monocyte/macrophage-derived THP-1 and U937 cells.	Benzo(a)pyrene	47-50	serpin family E member 1	Homo sapiens	216-221
29524502-8	2018	Thus, combined treatment with BaP and 1,25(OH)2D3 induced SERPINE1 mRNA expression in these cells through a mechanism that does not require de novo protein synthesis or reactive oxygen species production.	Benzo(a)pyrene	30-33	serpin family E member 1	Homo sapiens	58-66
29524502-9	2018	These findings suggest that induction of the proinflammatory factor PAI-1 plays a role in BaP toxicity.	Benzo(a)pyrene	90-93	serpin family E member 1	Homo sapiens	68-73
29524502-10	2018	Interestingly, PAI-1 knockdown decreased expression of the cell surface antigen CD14, a monocytic differentiation marker, in THP-1 cells treated with BaP plus 1,25(OH)2D3.	Benzo(a)pyrene	150-153	serpin family E member 1	Homo sapiens	15-20
29524502-10	2018	Interestingly, PAI-1 knockdown decreased expression of the cell surface antigen CD14, a monocytic differentiation marker, in THP-1 cells treated with BaP plus 1,25(OH)2D3.	Benzo(a)pyrene	150-153	GLI family zinc finger 2	Homo sapiens	125-130
29572430-5	2018	We report here that partial Rlip deficiency induced by weekly administration of an Rlip-specific phosphorothioate antisense oligonucleotide, R508, strongly inhibited spontaneous as well as benzo(a)pyrene-induced carcinogenesis in p53-/- mice.	Benzo(a)pyrene	189-203	transformation related protein 53	Mus musculus	230-233
29368147-0	2018	Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice.	Benzo(a)pyrene	65-79	cytochrome b5 type A (microsomal)	Mus musculus	0-14
29368147-1	2018	Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
29751397-6	2018	Furthermore, the gill EROD (Ethoxyresorufin-O-deethylase) assay showed a clear trend to CYP 1A (Cytochrom P450 1 A) induction via exposure to BaP-spiked microplastics.	Benzo(a)pyrene	142-145	cytochrome P450, family 1, subfamily A	Danio rerio	88-94
29446013-12	2018	In immunized rabbits, not only did more CD4+ T cells proliferate in response to BP re-stimulation, but the intensity of CD25 was increased indicating cell activation.	Benzo(a)pyrene	80-82	T-cell surface glycoprotein CD4	Oryctolagus cuniculus	40-43
29332834-6	2018	Moreover, benzo[a]pyrene and benzo[k]fluoranthene are marked by EPA as probably carcinogen compounds and also included into SCF and EU lists.	Benzo(a)pyrene	10-24	KIT ligand	Homo sapiens	124-127
29471073-1	2018	Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism.	Benzo(a)pyrene	41-55	prohibitin 2	Homo sapiens	57-60
29471073-1	2018	Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism.	Benzo(a)pyrene	41-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-92
29471073-1	2018	Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism.	Benzo(a)pyrene	41-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-100
29471073-1	2018	Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism.	Benzo(a)pyrene	41-55	tumor protein p53	Homo sapiens	108-111
29750188-1	2018	Polycyclic aromatic hydrocarbons like benzo(a)pyrene (BaP) in atmospheric particulate matter pose a threat to human health because of their high carcinogenicity.	Benzo(a)pyrene	38-52	prohibitin 2	Homo sapiens	54-57
29534036-0	2018	In Vitro Cocktail Effects of PCB-DL (PCB118) and Bulky PCB (PCB153) with BaP on Adipogenesis and on Expression of Genes Involved in the Establishment of a Pro-Inflammatory State.	Benzo(a)pyrene	73-76	pyruvate carboxylase	Mus musculus	29-32
29534036-0	2018	In Vitro Cocktail Effects of PCB-DL (PCB118) and Bulky PCB (PCB153) with BaP on Adipogenesis and on Expression of Genes Involved in the Establishment of a Pro-Inflammatory State.	Benzo(a)pyrene	73-76	pyruvate carboxylase	Mus musculus	37-40
29534036-2	2018	BaP enhanced the INFG, especially MCP-1 and TNFalpha.	Benzo(a)pyrene	0-3	mast cell protease 1	Mus musculus	34-39
29534036-2	2018	BaP enhanced the INFG, especially MCP-1 and TNFalpha.	Benzo(a)pyrene	0-3	tumor necrosis factor	Mus musculus	44-52
29534036-3	2018	Co-exposure to BaP and PCB153 showed a synergistic effect on TNFalpha and IL6 expression.	Benzo(a)pyrene	15-18	tumor necrosis factor	Mus musculus	61-69
29534036-3	2018	Co-exposure to BaP and PCB153 showed a synergistic effect on TNFalpha and IL6 expression.	Benzo(a)pyrene	15-18	interleukin 6	Mus musculus	74-77
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 &amp;amp; MCP-1).	Benzo(a)pyrene	15-18	interleukin 6	Mus musculus	85-88
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 &amp;amp; MCP-1).	Benzo(a)pyrene	15-18	tumor necrosis factor	Mus musculus	90-98
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 &amp;amp; MCP-1).	Benzo(a)pyrene	15-18	chemokine (C-X-C motif) ligand 10	Mus musculus	100-107
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 &amp;amp; MCP-1).	Benzo(a)pyrene	15-18	mast cell protease 1	Mus musculus	118-123
29182730-11	2018	CONCLUSION: SLC8A1 gene may contribute to BP change in the process of acute sodium loading in a Han Chinese population.	Benzo(a)pyrene	42-44	solute carrier family 8 member A1	Homo sapiens	12-18
29329358-10	2018	CONCLUSIONS: The results suggest that in AngII-dependent hypertension, Ang1-7 deficit contributes to sodium and fluid retention and thereby to BP elevation; a correction by Ang1-7 infusion seems mediated by AT1 and not Mas receptors.	Benzo(a)pyrene	143-145	angiotensinogen	Rattus norvegicus	41-46
29329358-10	2018	CONCLUSIONS: The results suggest that in AngII-dependent hypertension, Ang1-7 deficit contributes to sodium and fluid retention and thereby to BP elevation; a correction by Ang1-7 infusion seems mediated by AT1 and not Mas receptors.	Benzo(a)pyrene	143-145	angiogenin	Rattus norvegicus	71-77
29329358-10	2018	CONCLUSIONS: The results suggest that in AngII-dependent hypertension, Ang1-7 deficit contributes to sodium and fluid retention and thereby to BP elevation; a correction by Ang1-7 infusion seems mediated by AT1 and not Mas receptors.	Benzo(a)pyrene	143-145	angiogenin	Rattus norvegicus	71-75
29288728-0	2018	The rs243866/243865 polymorphisms in MMP-2 gene and the relationship with BP control in obese resistant hypertensive subjects.	Benzo(a)pyrene	74-76	matrix metallopeptidase 2	Homo sapiens	37-42
29288728-9	2018	Our study suggests that rs243866/rs243865 in the MMP-2 gene are related to BP levels in obese RH subjects, although TODs present in this population seem to be dependent of a combination of other factors besides the genetic polymorphisms.	Benzo(a)pyrene	75-77	matrix metallopeptidase 2	Homo sapiens	49-54
29196255-8	2018	The inhibition of PGCP expression by promoter hypermethylation was observed in both immortal HBETT cells and benzo[a]pyrene (Bap)-transformed HBE cells.	Benzo(a)pyrene	109-123	carboxypeptidase Q	Homo sapiens	18-22
29366871-0	2018	Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.	Benzo(a)pyrene	113-127	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-19
29366871-0	2018	Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.	Benzo(a)pyrene	113-127	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-27
29366871-3	2018	Cytochrome P450 1A1 (CYP1A1) metabolizes BaP, resulting in either detoxication or metabolic activation in a context-dependent manner.	Benzo(a)pyrene	41-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-19
29366871-3	2018	Cytochrome P450 1A1 (CYP1A1) metabolizes BaP, resulting in either detoxication or metabolic activation in a context-dependent manner.	Benzo(a)pyrene	41-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-27
29366871-5	2018	A Western diet plus BaP induced lipid-droplet accumulation in liver of Cyp1a1(-/-) mice, but not wild-type mice.	Benzo(a)pyrene	20-23	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	71-77
29366871-7	2018	Cyp1a1(-/-) mice fed Western diet plus BaP had changes in expression of genes involved in bile acid and lipid metabolism, and showed no increase in Cyp1a2 expression but did exhibit enhanced Cyp1b1 mRNA expression, as well as hepatic inflammation.	Benzo(a)pyrene	39-42	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-6
29366871-8	2018	Enhanced BaP metabolic activation, oxidative stress and inflammation may exacerbate metabolic dysfunction in liver of Cyp1a1(-/-) mice.	Benzo(a)pyrene	9-12	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	118-124
29366871-9	2018	Thus, Western diet plus BaP induces NAFLD and hepatic inflammation in Cyp1a1(-/-) mice in comparison to wild-type mice, indicating a protective role of CYP1A1 against NAFLD pathogenesis.	Benzo(a)pyrene	24-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	70-76
29366871-9	2018	Thus, Western diet plus BaP induces NAFLD and hepatic inflammation in Cyp1a1(-/-) mice in comparison to wild-type mice, indicating a protective role of CYP1A1 against NAFLD pathogenesis.	Benzo(a)pyrene	24-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	152-158
29473879-3	2018	As BP is a competitive inhibitor of human farnesyl pyrophosphate synthase (HFPPS), in silico molecular docking and dynamic simulations studies were established to evaluate the binding and stability of phosphinothricin with HFPPS, while the results showed good binding and stability in the active site of the enzyme in relation to alendronate.	Benzo(a)pyrene	3-5	farnesyl diphosphate synthase	Homo sapiens	42-73
29196255-8	2018	The inhibition of PGCP expression by promoter hypermethylation was observed in both immortal HBETT cells and benzo[a]pyrene (Bap)-transformed HBE cells.	Benzo(a)pyrene	125-128	carboxypeptidase Q	Homo sapiens	18-22
29301444-3	2018	It is a well-established fact that xenobiotics with planar structure like TCDD, benzo(a)pyrene (BP) can bind aryl hydrocarbon receptor (AhR) followed by its nuclear translocation and transcriptional activation of target genes.	Benzo(a)pyrene	80-94	aryl hydrocarbon receptor	Homo sapiens	109-134
29301444-3	2018	It is a well-established fact that xenobiotics with planar structure like TCDD, benzo(a)pyrene (BP) can bind aryl hydrocarbon receptor (AhR) followed by its nuclear translocation and transcriptional activation of target genes.	Benzo(a)pyrene	80-94	aryl hydrocarbon receptor	Homo sapiens	136-139
29301444-3	2018	It is a well-established fact that xenobiotics with planar structure like TCDD, benzo(a)pyrene (BP) can bind aryl hydrocarbon receptor (AhR) followed by its nuclear translocation and transcriptional activation of target genes.	Benzo(a)pyrene	96-98	aryl hydrocarbon receptor	Homo sapiens	109-134
29301444-3	2018	It is a well-established fact that xenobiotics with planar structure like TCDD, benzo(a)pyrene (BP) can bind aryl hydrocarbon receptor (AhR) followed by its nuclear translocation and transcriptional activation of target genes.	Benzo(a)pyrene	96-98	aryl hydrocarbon receptor	Homo sapiens	136-139
29223585-9	2018	Although plasma [NO2-] was elevated in all conditions, the consumption of a small, concentrated NO3--rich fluid (BR) was the most effective means of reducing BP.	Benzo(a)pyrene	158-160	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
29320557-4	2018	AhR has always been considered to be a regulator of toxic and carcinogenic responses to environmental contaminants such as TCDD (dioxin) and benzo[a]pyrene (BaP).	Benzo(a)pyrene	141-155	aryl hydrocarbon receptor	Homo sapiens	0-3
29320557-4	2018	AhR has always been considered to be a regulator of toxic and carcinogenic responses to environmental contaminants such as TCDD (dioxin) and benzo[a]pyrene (BaP).	Benzo(a)pyrene	157-160	aryl hydrocarbon receptor	Homo sapiens	0-3
29320557-10	2018	Two well-known ligands for AHR (TCDD and BaP) induced mRNA expression of IL1B and IL6 in an ERalpha-negative breast tumor cell line.	Benzo(a)pyrene	41-44	aryl hydrocarbon receptor	Homo sapiens	27-30
29320557-10	2018	Two well-known ligands for AHR (TCDD and BaP) induced mRNA expression of IL1B and IL6 in an ERalpha-negative breast tumor cell line.	Benzo(a)pyrene	41-44	interleukin 1 beta	Homo sapiens	73-77
29320557-10	2018	Two well-known ligands for AHR (TCDD and BaP) induced mRNA expression of IL1B and IL6 in an ERalpha-negative breast tumor cell line.	Benzo(a)pyrene	41-44	interleukin 6	Homo sapiens	82-85
29320557-10	2018	Two well-known ligands for AHR (TCDD and BaP) induced mRNA expression of IL1B and IL6 in an ERalpha-negative breast tumor cell line.	Benzo(a)pyrene	41-44	estrogen receptor 1	Homo sapiens	92-99
30108931-9	2018	Both isopimpinellin and karanjin negate the cellular toxicity of CYP1A1-mediated benzo[a]pyrene.	Benzo(a)pyrene	81-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	65-71
28715929-9	2018	Bisphenol PH (BP PH) was found to have significant affinity with CYP11B2.	Benzo(a)pyrene	14-16	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	65-72
29643980-1	2018	The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	183-197	prohibitin 2	Homo sapiens	199-202
29643980-1	2018	The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	183-197	aryl hydrocarbon receptor	Homo sapiens	227-252
29643980-1	2018	The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	183-197	aryl hydrocarbon receptor	Homo sapiens	254-257
28726518-8	2018	The present data suggest that the oxidative stress and reduced bioavailability of nitric oxide may contribute to attenuation of vasodilator responses to ACh and Ang II, and hyperreactivity to Ang II in the mesentery of preeclamptic rat, which may contribute to the increased peripheral vascular resistance and BP, as well as intrauterine growth restriction in L-NAME-induced PE.	Benzo(a)pyrene	310-312	angiotensinogen	Rattus norvegicus	192-198
29098723-5	2018	Increased frequencies of CD90-deficient mutants were detected in cells treated with benzo[a]pyrene (B[a]P), N-ethyl-N-nitrosourea (ENU), ethyl methanesulphonate, and 7,12-dimethylbenz[a]anthracene, with near maximum mutant frequencies measured eight days after treatment.	Benzo(a)pyrene	84-98	Thy-1 cell surface antigen	Sus scrofa	25-29
29680782-3	2018	The aim of this study was to achieve early identification in women with GDM of BP profiles (detected by ABPM) that could define a population at greater risk of developing PIH and preeclampsia.	Benzo(a)pyrene	79-81	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	171-174
29680782-11	2018	CONCLUSIONS: Patients with GDM have BP changes, with predominance of the non-dipper pattern and higher night-time systolic and diastolic BP, changes that could be useful predictors of PIH.	Benzo(a)pyrene	36-38	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	184-187
28904021-5	2018	In addition, BaP administration significantly decreased the fertilization rate of mouse eggs by reducing the number of sperm binding to the zona pellucida, which was consistent with the premature cleavage of N terminus of zona pellucida sperm-binding protein 2 and precocious exocytosis of ovastacin.	Benzo(a)pyrene	13-16	astacin-like metalloendopeptidase (M12 family)	Mus musculus	290-299
28993502-8	2018	Moreover, administration of recombinant soluble Klotho lowered BP in the Hyp mice.	Benzo(a)pyrene	63-65	klotho	Mus musculus	48-54
29021385-6	2018	Notably, a low-salt diet did not alter BP in wild-type mice, but significantly decreased BP in pendrin-knockout mice.	Benzo(a)pyrene	89-91	solute carrier family 26, member 4	Mus musculus	95-102
28782227-0	2018	Short androgen receptor poly-glutamine-promoted endometrial cancer is associated with benzo[a]pyrene-mediated aryl hydrocarbon receptor activation.	Benzo(a)pyrene	86-100	androgen receptor	Homo sapiens	6-23
28782227-0	2018	Short androgen receptor poly-glutamine-promoted endometrial cancer is associated with benzo[a]pyrene-mediated aryl hydrocarbon receptor activation.	Benzo(a)pyrene	86-100	aryl hydrocarbon receptor	Homo sapiens	110-135
28990324-7	2018	In addition, STC2-/- mice present enhanced pancreas size; thus, the histological analysis reveals that WT mice respond to BP diet by increasing the size of the pancreatic islets through inducing cell division, and STC2-/- mice lack this compensatory mechanism.	Benzo(a)pyrene	122-124	stanniocalcin 2	Mus musculus	13-17
28990324-9	2018	Histopathological analysis demonstrates tissue structure disruption and erythrocytes infiltrations in STC2-/- mice, possibly due to the stress evoked by the BP diet.	Benzo(a)pyrene	157-159	stanniocalcin 2	Mus musculus	102-106
28914726-10	2018	From pretreatment to posttreatment, CBTI-BP compared with psychoeducation was associated with a nonsignificant, large effect size decrease in IL-6 (z = -1.61, p = .13, d = -0.78) and a nonsignificant, small-medium effect size decrease in sTNF-R2 (z = -0.79, p = .44, d = -0.38).	Benzo(a)pyrene	41-43	interleukin 6	Homo sapiens	142-146
28715929-11	2018	BP PH elicited better results than the standard Abiraterone acetate against CYP17A1.	Benzo(a)pyrene	0-2	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	76-83
28715929-13	2018	Upon molecular docking of BP PH against CYP21A2, it was seen that amongst all the analogs, it had maximum interactions along with the lowest D score.	Benzo(a)pyrene	26-28	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	40-47
28990778-9	2017	The pyroptosis inhibitor Ac-YVAD-CM also notably (p &lt; 0.01) blocked BaP-induced autophagic cell death characterized by the increase of autophagic vacuoles and overexpression of Beclin-1 and LC3-II.	Benzo(a)pyrene	71-74	beclin 1	Homo sapiens	180-188
29111668-1	2017	Benzo[a]pyrene (BaP), an archetypical polycyclic aromatic hydrocarbon, is classified as "carcinogenic to humans" and is ubiquitous in the environment, as evident by the measurable levels of BaP metabolites in virtually all human urine samples examined.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
29111668-1	2017	Benzo[a]pyrene (BaP), an archetypical polycyclic aromatic hydrocarbon, is classified as "carcinogenic to humans" and is ubiquitous in the environment, as evident by the measurable levels of BaP metabolites in virtually all human urine samples examined.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	190-193
28807506-0	2017	Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.	Benzo(a)pyrene	61-75	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	79-84
28807506-0	2017	Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.	Benzo(a)pyrene	61-75	signal transducer and activator of transcription 4	Homo sapiens	86-91
28807506-0	2017	Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.	Benzo(a)pyrene	61-75	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102
29076178-3	2017	In this study, we examined genotoxicity of benzo[a]pyrene (BP) to determine whether Polk actually suppressed BP-induced genotoxicity as predicted by biochemistry and in vitro cell culture studies.	Benzo(a)pyrene	109-111	polymerase (DNA directed), kappa	Mus musculus	84-88
29076178-8	2017	The results suggest that Polk has a limited ability to suppress BP-induced genotoxicity in the colon and bone marrow and also that the roles of specialized DNA polymerases in mutagenesis and carcinogenesis should be examined not only by in vitro assays but also by in vivo mouse studies.	Benzo(a)pyrene	64-66	polymerase (DNA directed), kappa	Mus musculus	25-29
28659018-4	2017	The highest concentration of benzo(a)pyrene (BaP) was 2.85 mug kg-1 in milk powder.	Benzo(a)pyrene	29-43	prohibitin 2	Homo sapiens	45-48
28923913-5	2017	In db/db mice, systemic administration of an miR-25 agomir repressed glomerular fibrosis and reduced high BP.	Benzo(a)pyrene	106-108	microRNA 25	Mus musculus	45-51
29150045-0	2017	Spectrum of benzo[a]pyrene-induced mutations in the Pig-a gene of L5178YTk+/- cells identified with next generation sequencing.	Benzo(a)pyrene	12-26	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	52-57
29180756-7	2017	Spatiotemporal analysis revealed these asymmetrical BP nsEP exposures generate distinct local YO-PRO -1 uptake patterns across the plasma membrane.	Benzo(a)pyrene	52-54	lamin A/C	Homo sapiens	97-103
28534121-6	2017	Here we show that OAT1 and OAT3 enabled cells to take up BP (BH4 and/or BH2) in a probenecid-sensitive manner using rat kidney slices and transporter-expressing cell systems, LLC-PK1 cells and Xenopus oocytes.	Benzo(a)pyrene	57-59	solute carrier family 22 member 6	Rattus norvegicus	18-22
28534121-6	2017	Here we show that OAT1 and OAT3 enabled cells to take up BP (BH4 and/or BH2) in a probenecid-sensitive manner using rat kidney slices and transporter-expressing cell systems, LLC-PK1 cells and Xenopus oocytes.	Benzo(a)pyrene	57-59	solute carrier family 22 member 8	Rattus norvegicus	27-31
28534121-9	2017	These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4.	Benzo(a)pyrene	109-111	solute carrier family 22 member 6	Rattus norvegicus	29-33
28534121-9	2017	These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4.	Benzo(a)pyrene	109-111	solute carrier family 22 member 8	Rattus norvegicus	38-42
28534121-9	2017	These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4.	Benzo(a)pyrene	136-138	solute carrier family 22 member 6	Rattus norvegicus	29-33
28534121-9	2017	These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4.	Benzo(a)pyrene	136-138	solute carrier family 22 member 8	Rattus norvegicus	38-42
29066763-7	2017	UII raises BP transiently when sodium intake and renal function are normal, but progressively in salt-loaded uninephrectomized rats.	Benzo(a)pyrene	11-13	urotensin 2	Rattus norvegicus	0-3
28843737-9	2017	Ethoxyresorufin-o-deethylase (EROD) assay suggested that TCS is a weak P4501a (Cyp1a) agonist at 5muM and that it inhibits cytochrome Cyp1a activity induced by benzo(a)pyrene (BaP).	Benzo(a)pyrene	160-174	cytochrome P450, family 1, subfamily A	Danio rerio	134-139
28843737-9	2017	Ethoxyresorufin-o-deethylase (EROD) assay suggested that TCS is a weak P4501a (Cyp1a) agonist at 5muM and that it inhibits cytochrome Cyp1a activity induced by benzo(a)pyrene (BaP).	Benzo(a)pyrene	176-179	cytochrome P450, family 1, subfamily A	Danio rerio	134-139
28701518-4	2017	Studies in animal models suggest that changes in the production of cytochrome P450 eicosanoids alter BP.	Benzo(a)pyrene	101-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-82
28791412-0	2017	Benzo(a)pyrene enhances the EMT-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.	Benzo(a)pyrene	0-14	IL2 inducible T cell kinase	Homo sapiens	28-31
28791412-0	2017	Benzo(a)pyrene enhances the EMT-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.	Benzo(a)pyrene	0-14	twist family bHLH transcription factor 1	Homo sapiens	103-109
28791412-3	2017	BaP (1 microM) promoted the migration of A549 cells in a time-dependent manner and upregulated the expression of the Twist family BHLH transcription factor 1 (Twist1).	Benzo(a)pyrene	0-3	twist family bHLH transcription factor 1	Homo sapiens	159-165
28791412-4	2017	BaP also induced upregulation of the mesenchymal markers N-cadherin and vimentin and downregulation of the epithelial marker E-cadherin.	Benzo(a)pyrene	0-3	cadherin 2	Homo sapiens	57-67
28791412-4	2017	BaP also induced upregulation of the mesenchymal markers N-cadherin and vimentin and downregulation of the epithelial marker E-cadherin.	Benzo(a)pyrene	0-3	vimentin	Homo sapiens	72-80
28791412-4	2017	BaP also induced upregulation of the mesenchymal markers N-cadherin and vimentin and downregulation of the epithelial marker E-cadherin.	Benzo(a)pyrene	0-3	cadherin 1	Homo sapiens	125-135
28791412-5	2017	When the expression of Twist1 was knocked down in A549 cells that were treated with BaP for 4 weeks (A549BaP-4w), the expression of Twist1 decreased, which inhibited the migration capacity of A549BaP-4w cells, the expression of N-cadherin and vimentin was downregulated and the expression of E-cadherin was upregulated.	Benzo(a)pyrene	84-87	twist family bHLH transcription factor 1	Homo sapiens	23-29
28791412-5	2017	When the expression of Twist1 was knocked down in A549 cells that were treated with BaP for 4 weeks (A549BaP-4w), the expression of Twist1 decreased, which inhibited the migration capacity of A549BaP-4w cells, the expression of N-cadherin and vimentin was downregulated and the expression of E-cadherin was upregulated.	Benzo(a)pyrene	84-87	twist family bHLH transcription factor 1	Homo sapiens	132-138
28791412-5	2017	When the expression of Twist1 was knocked down in A549 cells that were treated with BaP for 4 weeks (A549BaP-4w), the expression of Twist1 decreased, which inhibited the migration capacity of A549BaP-4w cells, the expression of N-cadherin and vimentin was downregulated and the expression of E-cadherin was upregulated.	Benzo(a)pyrene	84-87	cadherin 2	Homo sapiens	228-238
28791412-5	2017	When the expression of Twist1 was knocked down in A549 cells that were treated with BaP for 4 weeks (A549BaP-4w), the expression of Twist1 decreased, which inhibited the migration capacity of A549BaP-4w cells, the expression of N-cadherin and vimentin was downregulated and the expression of E-cadherin was upregulated.	Benzo(a)pyrene	84-87	vimentin	Homo sapiens	243-251
28791412-5	2017	When the expression of Twist1 was knocked down in A549 cells that were treated with BaP for 4 weeks (A549BaP-4w), the expression of Twist1 decreased, which inhibited the migration capacity of A549BaP-4w cells, the expression of N-cadherin and vimentin was downregulated and the expression of E-cadherin was upregulated.	Benzo(a)pyrene	84-87	cadherin 1	Homo sapiens	292-302
28791412-8	2017	In conclusion, the results from the present study indicate that BaP enhances the epithelial-mesenchymal transition-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.	Benzo(a)pyrene	64-67	twist family bHLH transcription factor 1	Homo sapiens	186-192
28715731-0	2017	Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro.	Benzo(a)pyrene	35-49	phospholipase A2 group IB	Rattus norvegicus	134-150
28715731-12	2017	Mechanically, BaP (4muM) increased the phospholipase A2 (PLA2) activity at 4h as well as the mRNA level of Pla2g2a at 12h.	Benzo(a)pyrene	14-17	phospholipase A2 group IB	Rattus norvegicus	39-55
28715731-12	2017	Mechanically, BaP (4muM) increased the phospholipase A2 (PLA2) activity at 4h as well as the mRNA level of Pla2g2a at 12h.	Benzo(a)pyrene	14-17	phospholipase A2 group IB	Rattus norvegicus	57-61
28715731-12	2017	Mechanically, BaP (4muM) increased the phospholipase A2 (PLA2) activity at 4h as well as the mRNA level of Pla2g2a at 12h.	Benzo(a)pyrene	14-17	phospholipase A2 group IIA	Rattus norvegicus	107-114
28715731-13	2017	The pro-inflammatory effect of BaP was reversed by the cytosolic PLA2 (cPLA2) inhibitor and chelator of intracellular Ca2+.	Benzo(a)pyrene	31-34	phospholipase A2 group IVA	Rattus norvegicus	55-69
28715731-13	2017	The pro-inflammatory effect of BaP was reversed by the cytosolic PLA2 (cPLA2) inhibitor and chelator of intracellular Ca2+.	Benzo(a)pyrene	31-34	phospholipase A2 group IVA	Rattus norvegicus	71-76
28715731-14	2017	This study revealed that BaP, as a component of PM2.5, induces pulmonary injury by activating PLA2 and elevating lysophosphatidylcholine (LPC) in a Ca2+-dependent manner in the alveolar type II cells.	Benzo(a)pyrene	25-28	phospholipase A2 group IB	Rattus norvegicus	94-98
28629854-5	2017	OAT3 activity was further demonstrated to be blocked by some single chemicals present in cigarette smoke such as the heterocyclic amines AalphaC (IC50=11.3muM) and PhIP (IC50=1.9muM), whereas other major cigarette smoke components used at 100muM, like nicotine, the nitrosamine NNK and the polycyclic aromatic hydrocarbons benzo(a)pyrene and phenanthrene, were without effect.	Benzo(a)pyrene	323-337	solute carrier family 22 member 8	Homo sapiens	0-4
28784314-0	2017	Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model.	Benzo(a)pyrene	75-89	clusterin	Homo sapiens	0-9
28784314-0	2017	Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model.	Benzo(a)pyrene	75-89	neuropilin 2	Homo sapiens	14-26
28784314-1	2017	Benzo[a]pyrene (BaP) is a ubiquitous environment contaminant and its exposure could increase incidence of human lung cancer.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
28912492-4	2017	Epicutaneous administration of rBet v 1 and rBet v 1 fragments led to strong and significant increases of allergen-specific T cell proliferation (CLA+ and CCR4+T cell responses) only in bp-allergic patients with a positive APT reaction.	Benzo(a)pyrene	186-188	immunoglobulin kappa variable 1-5	Homo sapiens	36-52
28111842-4	2017	4 days), BaP in the liver and lung of HRN-gpt mice were increased.	Benzo(a)pyrene	9-12	glutamic pyruvic transaminase, soluble	Mus musculus	42-45
29042535-0	2017	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.	Benzo(a)pyrene	43-57	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	75-79
28444933-8	2017	BaP increased CD86 expression as an APC surface molecule regardless of the presence or absence of H-DEP.	Benzo(a)pyrene	0-3	CD86 antigen	Mus musculus	14-18
28673838-2	2017	In this study, we examined the effects of benzo(a)pyrene (B(a)P), a main CS component, on the viability and apoptosis of JEG-3 and BeWo human choriocarcinoma cancer cell lines.	Benzo(a)pyrene	42-56	prohibitin 2	Homo sapiens	58-63
28676325-0	2017	Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.	Benzo(a)pyrene	75-89	aryl hydrocarbon receptor	Homo sapiens	15-40
28676325-0	2017	Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.	Benzo(a)pyrene	75-89	aryl hydrocarbon receptor	Homo sapiens	42-45
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	GLI family zinc finger 1	Homo sapiens	72-126
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	GLI family zinc finger 1	Homo sapiens	128-131
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	GLI family zinc finger 1	Homo sapiens	194-199
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	GLI family zinc finger 2	Homo sapiens	201-206
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	smoothened, frizzled class receptor	Homo sapiens	208-218
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	smoothened, frizzled class receptor	Homo sapiens	220-223
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	catenin beta 1	Homo sapiens	230-242
28473636-8	2017	Thus, acute eGFR declines &gt;=20% during intensive BP lowering identified a subset of patients at higher risk for adverse outcomes.	Benzo(a)pyrene	52-54	epidermal growth factor receptor	Homo sapiens	12-16
28882572-6	2017	In addition to the top candidate p53, we identified several other interesting TFs that modulated gamma-H2AX after BaP and AFB1 treatment.	Benzo(a)pyrene	114-117	H2A.X variant histone	Homo sapiens	97-107
28882572-7	2017	Validation studies confirmed the role of p53 in reducing gamma-H2AX formation and DNA breaks measured by COMET assay after BaP and AFB1 exposure.	Benzo(a)pyrene	123-126	tumor protein p53	Homo sapiens	41-44
28882572-10	2017	Although p63 knock-down affected DNA damage upon BaP treatment this was not associated with altered expression of DDB2 or XPC.	Benzo(a)pyrene	49-52	tumor protein p63	Homo sapiens	9-12
28882572-11	2017	Finally, knock-down of ARNT reduced gamma-H2AX in response to BaP, which was associated with reduced CYP1A1 expression.	Benzo(a)pyrene	62-65	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	23-27
28882572-11	2017	Finally, knock-down of ARNT reduced gamma-H2AX in response to BaP, which was associated with reduced CYP1A1 expression.	Benzo(a)pyrene	62-65	H2A.X variant histone	Homo sapiens	36-46
28882572-11	2017	Finally, knock-down of ARNT reduced gamma-H2AX in response to BaP, which was associated with reduced CYP1A1 expression.	Benzo(a)pyrene	62-65	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	101-107
28634217-13	2017	CONCLUSIONS: Although higher BP levels are associated with increased CVD risk, in the modern era, the majority of incident CVD events occur in US adults with SBP/DBP &lt;140/90 mm Hg.	Benzo(a)pyrene	29-31	selenium binding protein 1	Homo sapiens	158-161
28634217-13	2017	CONCLUSIONS: Although higher BP levels are associated with increased CVD risk, in the modern era, the majority of incident CVD events occur in US adults with SBP/DBP &lt;140/90 mm Hg.	Benzo(a)pyrene	29-31	D-box binding PAR bZIP transcription factor	Homo sapiens	162-165
28583304-1	2017	Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor 1a	Danio rerio	126-151
28583304-1	2017	Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor 1a	Danio rerio	153-156
28461126-1	2017	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes.	Benzo(a)pyrene	49-63	aryl hydrocarbon receptor	Homo sapiens	211-236
28461126-1	2017	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes.	Benzo(a)pyrene	49-63	aryl hydrocarbon receptor	Homo sapiens	238-241
28461126-1	2017	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes.	Benzo(a)pyrene	49-63	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	286-311
28461126-1	2017	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes.	Benzo(a)pyrene	65-70	aryl hydrocarbon receptor	Homo sapiens	211-236
28461126-1	2017	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes.	Benzo(a)pyrene	65-70	aryl hydrocarbon receptor	Homo sapiens	238-241
28461126-1	2017	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes.	Benzo(a)pyrene	65-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	286-311
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	196-202
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	203-209
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	catechol-O-methyltransferase	Homo sapiens	210-214
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	epidermal growth factor receptor	Homo sapiens	216-220
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	tumor protein p53	Homo sapiens	240-243
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	tumor protein p53	Homo sapiens	319-322
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	184-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	196-202
27913846-8	2017	As representative PCB compounds, 2,3,3"-trichlorobiphenyl and 2,3,4"-trichlorobiphenyl induced micronuclei in L-02 cells, and this effect was blocked by specific CYP2E1 inhibition, wherein the effects of benzo[a]pyrene and aflatoxin B1 (activated by some CYPs other than CYP2E1) were unaffected.	Benzo(a)pyrene	204-218	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	162-168
28111842-5	2017	BaP promoted gpt mutant frequency (MF) in HRN-gpt mice liver.	Benzo(a)pyrene	0-3	glutamic pyruvic transaminase, soluble	Mus musculus	13-16
28111842-5	2017	BaP promoted gpt mutant frequency (MF) in HRN-gpt mice liver.	Benzo(a)pyrene	0-3	glutamic pyruvic transaminase, soluble	Mus musculus	46-49
28111842-6	2017	MF of gpt in the lung and Pig-a in hematopoietic cells induced by BaP in HRN-gpt mice were increased than in gpt mice.	Benzo(a)pyrene	66-69	alanine aminotransferase 1	Sus scrofa	6-9
28111842-6	2017	MF of gpt in the lung and Pig-a in hematopoietic cells induced by BaP in HRN-gpt mice were increased than in gpt mice.	Benzo(a)pyrene	66-69	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	26-31
28111842-6	2017	MF of gpt in the lung and Pig-a in hematopoietic cells induced by BaP in HRN-gpt mice were increased than in gpt mice.	Benzo(a)pyrene	66-69	alanine aminotransferase 1	Sus scrofa	77-80
28111842-6	2017	MF of gpt in the lung and Pig-a in hematopoietic cells induced by BaP in HRN-gpt mice were increased than in gpt mice.	Benzo(a)pyrene	66-69	glutamic pyruvic transaminase, soluble	Mus musculus	77-80
27669189-11	2017	During the different BP modes, the SMBP and BBP elicited significantly greater TB activity vs. the DBP.	Benzo(a)pyrene	21-23	transmembrane 9 superfamily member 3	Homo sapiens	35-39
27669189-11	2017	During the different BP modes, the SMBP and BBP elicited significantly greater TB activity vs. the DBP.	Benzo(a)pyrene	21-23	transmembrane protein 158	Homo sapiens	44-47
28900085-0	2017	[Expression of miR-21 and Its Acat1, Armcx1, and Pten Target Genes in Liver of Female Rats Treated with DDT and Benzo[a]pyrene].	Benzo(a)pyrene	112-126	microRNA 21	Rattus norvegicus	15-21
28489395-11	2017	The compound 119 rescued CYP1A1 overexpressing HEK293 cells from CYP1A1 mediated benzo[a]pyrene (B[a]P) toxicity and also overcame cisplatin resistance in CYP1B1 overexpressing HEK293 cells.	Benzo(a)pyrene	81-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31
28489395-11	2017	The compound 119 rescued CYP1A1 overexpressing HEK293 cells from CYP1A1 mediated benzo[a]pyrene (B[a]P) toxicity and also overcame cisplatin resistance in CYP1B1 overexpressing HEK293 cells.	Benzo(a)pyrene	81-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	65-71
28460163-0	2017	Nucleotide Excision Repair Lesion-Recognition Protein Rad4 Captures a Pre-Flipped Partner Base in a Benzo[a]pyrene-Derived DNA Lesion: How Structure Impacts the Binding Pathway.	Benzo(a)pyrene	100-114	Rad4p	Saccharomyces cerevisiae S288C	54-58
28607424-0	2017	Benzo(a)pyrene triggers desensitization of beta2-adrenergic pathway.	Benzo(a)pyrene	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	43-48
29048787-3	2017	The separation of benzo[a]pyrene was carried out on an XBridge BEH C18 column with gradient elution of methanol and water.	Benzo(a)pyrene	18-32	Bardet-Biedl syndrome 9	Homo sapiens	67-70
28356338-0	2017	Time-Varying Association of Individual BP Components with eGFR in Late-Stage CKD.	Benzo(a)pyrene	39-41	epidermal growth factor receptor	Homo sapiens	58-62
28356338-1	2017	BACKGROUND AND OBJECTIVES: The association of individual BP components with changes in eGFR in patients with late-stage CKD is unknown.	Benzo(a)pyrene	57-59	epidermal growth factor receptor	Homo sapiens	87-91
28356338-5	2017	The associations of BP components and eGFR decline &gt;=30% were examined with time-varying Cox models.	Benzo(a)pyrene	20-22	epidermal growth factor receptor	Homo sapiens	38-42
28341327-1	2017	The desorption kinetics and mechanism were investigated using a Tenax extraction technique on different sediments spiked with radiocarbon-labeled benzo[a]pyrene (BaP).	Benzo(a)pyrene	146-160	prohibitin 2	Homo sapiens	162-165
28249752-2	2017	Benzo[a]pyrene (BaP)-a cigarette smoke component and powerful motivator of the aryl hydrocarbon receptor (Ahr)-unfavorably influences bone condition and osteoblast differentiation.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
28249752-2	2017	Benzo[a]pyrene (BaP)-a cigarette smoke component and powerful motivator of the aryl hydrocarbon receptor (Ahr)-unfavorably influences bone condition and osteoblast differentiation.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	79-104
28249752-2	2017	Benzo[a]pyrene (BaP)-a cigarette smoke component and powerful motivator of the aryl hydrocarbon receptor (Ahr)-unfavorably influences bone condition and osteoblast differentiation.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	106-109
28351761-8	2017	Knockdown AhR expression with short-hairpin RNA (shRNA) significantly reduced benzo[a]pyrene (BaP)-induced IL-24 mRNA levels.	Benzo(a)pyrene	78-92	aryl hydrocarbon receptor	Homo sapiens	10-13
28351761-8	2017	Knockdown AhR expression with short-hairpin RNA (shRNA) significantly reduced benzo[a]pyrene (BaP)-induced IL-24 mRNA levels.	Benzo(a)pyrene	78-92	interleukin 24	Homo sapiens	107-112
28351761-8	2017	Knockdown AhR expression with short-hairpin RNA (shRNA) significantly reduced benzo[a]pyrene (BaP)-induced IL-24 mRNA levels.	Benzo(a)pyrene	94-97	aryl hydrocarbon receptor	Homo sapiens	10-13
28351761-8	2017	Knockdown AhR expression with short-hairpin RNA (shRNA) significantly reduced benzo[a]pyrene (BaP)-induced IL-24 mRNA levels.	Benzo(a)pyrene	94-97	interleukin 24	Homo sapiens	107-112
28351761-9	2017	We further confirmed that gene transcription, but not mRNA stability, was involved in IL-24 upregulation by BaP.	Benzo(a)pyrene	108-111	interleukin 24	Homo sapiens	86-91
28531207-0	2017	Benzo[a]pyrene activates interleukin-6 induction and suppresses nitric oxide-induced apoptosis in rat vascular smooth muscle cells.	Benzo(a)pyrene	0-14	interleukin 6	Rattus norvegicus	25-38
28531207-10	2017	Benzo[a]pyrene was capable of inducing the activation of nuclear factor (NF)-kappaB and phosphorylation of p38 mitogen-activated protein kinase (MAPK) in VSMCs.	Benzo(a)pyrene	0-14	mitogen activated protein kinase 14	Rattus norvegicus	107-143
28531207-12	2017	Incubation of VSMCs with benzo[a]pyrene significantly and dose-dependently increased interleukin (IL)-6 production.	Benzo(a)pyrene	25-39	interleukin 6	Rattus norvegicus	85-103
28531207-13	2017	A neutralizing antibody to IL-6 effectively reversed the anti-apoptotic effect of benzo[a]pyrene on SNP-treated VSMCs.	Benzo(a)pyrene	82-96	interleukin 6	Rattus norvegicus	27-31
28531207-14	2017	Taken together, these results demonstrate for the first time that benzo[a]pyrene activates IL-6 induction and protects VSMCs from NO-induced apoptosis.	Benzo(a)pyrene	66-80	interleukin 6	Rattus norvegicus	91-95
28373666-5	2017	Bedsides, LP and BP also slightly increased bone resorption activity compared with OVX, evidenced by increased RANKL/OPG ratio.	Benzo(a)pyrene	17-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	111-116
28522830-4	2017	Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations.	Benzo(a)pyrene	158-172	CD1a molecule	Homo sapiens	48-52
28522830-4	2017	Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations.	Benzo(a)pyrene	158-172	CD1d molecule	Homo sapiens	57-61
28522830-4	2017	Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations.	Benzo(a)pyrene	158-172	CD1a molecule	Homo sapiens	94-98
28522830-4	2017	Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations.	Benzo(a)pyrene	158-172	CD1d molecule	Homo sapiens	104-108
27830268-0	2017	Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.	Benzo(a)pyrene	68-82	histone deacetylase 9	Homo sapiens	91-110
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	212-226	histone deacetylase 9	Homo sapiens	50-69
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	212-226	histone deacetylase 9	Homo sapiens	71-75
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	212-226	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-143
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	228-231	histone deacetylase 9	Homo sapiens	50-69
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	228-231	histone deacetylase 9	Homo sapiens	71-75
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	228-231	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-137
27830268-2	2017	In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells.	Benzo(a)pyrene	228-231	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-143
27830268-3	2017	Sodium butyrate (NaBt) strongly potentiated the BaP-induced expression of CYP1A1 in human colon carcinoma HCT116 cells.	Benzo(a)pyrene	48-51	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
27830268-5	2017	Up-regulation of CYP1A1 expression/activity corresponded with an enhanced metabolism of BaP and formation of covalent DNA adducts.	Benzo(a)pyrene	88-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	17-23
27830268-9	2017	This in vitro study suggests that butyrate, through modulation of histone acetylation, may potentiate induction of CYP1A1 expression, which might in turn alter the metabolism of BaP within colon epithelial cells.	Benzo(a)pyrene	178-181	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	115-121
27731323-4	2017	In mice with ovalbumin (OVA) or birch pollen (BP)-induced allergic asthma, C1q is as efficacious as dexamethasone to reduce both airway hyperresponsiveness (AHR), eosinophil, and ILC2 infiltrates in bronchoalveolar lavages, as well as allergen-specific T helper 2 cells in the lungs.	Benzo(a)pyrene	46-48	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	75-78
28238931-0	2017	Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells.	Benzo(a)pyrene	32-46	C-X-C motif chemokine ligand 8	Homo sapiens	10-28
28238931-9	2017	These findings suggest that IL-8 increased the formation of B[a]P-7,8-diol despite an overall delayed B[a]P metabolism via depletion of GSH, but DNA damage levels were unaffected due to an increase in NER capacity.	Benzo(a)pyrene	60-65	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28405246-0	2017	Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-57
28405246-4	2017	Therefore, AhR activators are suspected to have the potential to aggravate the toxicity of BaP through the induction of CYP1A1.	Benzo(a)pyrene	91-94	aryl hydrocarbon receptor	Homo sapiens	11-14
28405246-4	2017	Therefore, AhR activators are suspected to have the potential to aggravate the toxicity of BaP through the induction of CYP1A1.	Benzo(a)pyrene	91-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	120-126
28405246-5	2017	Besides, CYP1A1 inhibitors, including its substrates, are estimated to have preventive effects against BaP toxicity.	Benzo(a)pyrene	103-106	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	9-15
28405246-6	2017	However, strangely, increased hepatic BaP-DNA adduct levels have been reported in Cyp1a1 knockout mice.	Benzo(a)pyrene	38-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-88
28405246-7	2017	Moreover, numerous reports describe that concomitant treatment of AhR activators reduced BaP-DNA adduct formation.	Benzo(a)pyrene	89-92	aryl hydrocarbon receptor	Homo sapiens	66-69
28405246-10	2017	To interpret these complicated outcomes, we propose a hypothesis that CYP1A1 is a key enzyme for both generation and reduction of (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), the major carcinogenic intermediate of BaP.	Benzo(a)pyrene	224-227	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	70-76
28405246-11	2017	Conversely, CYP1B1 is thought to contribute only to the metabolic activation of BaP related to carcinogenesis.	Benzo(a)pyrene	80-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	12-18
28373666-5	2017	Bedsides, LP and BP also slightly increased bone resorption activity compared with OVX, evidenced by increased RANKL/OPG ratio.	Benzo(a)pyrene	17-19	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	117-120
27277573-7	2017	Calves in the BP treatment had greater (p &lt; 0.05) average daily gain (ADG) than CON and WS treatments, but similar to AH calves.	Benzo(a)pyrene	14-16	ADG	Bos taurus	73-76
27277573-8	2017	Digestibility of NDF and ADF was greater (p &lt; 0.05) in BP treatment than other treatments.	Benzo(a)pyrene	58-60	destrin, actin depolymerizing factor	Bos taurus	25-28
27277573-13	2017	It was concluded that BP improves final body weight, ADG and nutrient digestibility of calves than starter without forage provision during weaning transition.	Benzo(a)pyrene	22-24	ADG	Bos taurus	53-56
28279692-1	2017	Females deficient in the glutamate cysteine ligase modifier subunit (Gclm) of the rate-limiting enzyme in glutathione synthesis are more sensitive to ovarian follicle depletion and tumorigenesisby prenatal benzo[a]pyrene (BaP) exposure than Gclm+/+ mice.	Benzo(a)pyrene	206-220	glutamate-cysteine ligase, modifier subunit	Mus musculus	25-74
28279692-1	2017	Females deficient in the glutamate cysteine ligase modifier subunit (Gclm) of the rate-limiting enzyme in glutathione synthesis are more sensitive to ovarian follicle depletion and tumorigenesisby prenatal benzo[a]pyrene (BaP) exposure than Gclm+/+ mice.	Benzo(a)pyrene	206-220	glutamate-cysteine ligase, modifier subunit	Mus musculus	69-73
28279692-1	2017	Females deficient in the glutamate cysteine ligase modifier subunit (Gclm) of the rate-limiting enzyme in glutathione synthesis are more sensitive to ovarian follicle depletion and tumorigenesisby prenatal benzo[a]pyrene (BaP) exposure than Gclm+/+ mice.	Benzo(a)pyrene	222-225	glutamate-cysteine ligase, modifier subunit	Mus musculus	25-74
28279692-1	2017	Females deficient in the glutamate cysteine ligase modifier subunit (Gclm) of the rate-limiting enzyme in glutathione synthesis are more sensitive to ovarian follicle depletion and tumorigenesisby prenatal benzo[a]pyrene (BaP) exposure than Gclm+/+ mice.	Benzo(a)pyrene	222-225	glutamate-cysteine ligase, modifier subunit	Mus musculus	69-73
28279692-4	2017	Puberty onset occurred 5 days earlier in F1 daughters of all Gclm genotypes exposed to BaP compared to controls.	Benzo(a)pyrene	87-90	glutamate-cysteine ligase, modifier subunit	Mus musculus	61-65
28260342-0	2017	[Study on the expression of epidermal growth factor receptor protein during benzo(a)pyrene induced carcinogenesis].	Benzo(a)pyrene	76-90	epidermal growth factor receptor	Rattus norvegicus	28-60
28260342-1	2017	Objective: To explore the expression of epidermal growth factor receptor(EGFR) protein during benzo(a)pyrene (BaP) induced carcinogenesis.	Benzo(a)pyrene	94-108	epidermal growth factor receptor	Rattus norvegicus	40-72
28260342-1	2017	Objective: To explore the expression of epidermal growth factor receptor(EGFR) protein during benzo(a)pyrene (BaP) induced carcinogenesis.	Benzo(a)pyrene	94-108	epidermal growth factor receptor	Rattus norvegicus	73-77
28260342-1	2017	Objective: To explore the expression of epidermal growth factor receptor(EGFR) protein during benzo(a)pyrene (BaP) induced carcinogenesis.	Benzo(a)pyrene	110-113	epidermal growth factor receptor	Rattus norvegicus	40-72
28260342-1	2017	Objective: To explore the expression of epidermal growth factor receptor(EGFR) protein during benzo(a)pyrene (BaP) induced carcinogenesis.	Benzo(a)pyrene	110-113	epidermal growth factor receptor	Rattus norvegicus	73-77
28260342-2	2017	Methods: This study, we firstly utilized immunofluorescence assay and Western-blot to examine EGFR expression of the BaP which was constructed previously by project team induced malignant transformation human bronchial epithelial cell (BTC) and the control (16HBE cell).	Benzo(a)pyrene	117-120	epidermal growth factor receptor	Homo sapiens	94-98
28260342-11	2017	Conclusion: Expression of EGFR protein was increased during BaP carcinogenesis, and EGFR may play an important role in the carcinogenesis of BaP.	Benzo(a)pyrene	60-63	epidermal growth factor receptor	Rattus norvegicus	26-30
28260342-11	2017	Conclusion: Expression of EGFR protein was increased during BaP carcinogenesis, and EGFR may play an important role in the carcinogenesis of BaP.	Benzo(a)pyrene	141-144	epidermal growth factor receptor	Rattus norvegicus	26-30
28260342-11	2017	Conclusion: Expression of EGFR protein was increased during BaP carcinogenesis, and EGFR may play an important role in the carcinogenesis of BaP.	Benzo(a)pyrene	141-144	epidermal growth factor receptor	Rattus norvegicus	84-88
27930925-8	2017	Immunolabeling revealed that the association of BP and GT caused a slight disturbance in OPG/RANKL system and retarded Runx-2 labeling.	Benzo(a)pyrene	48-50	TNF receptor superfamily member 11B	Rattus norvegicus	89-92
27930925-8	2017	Immunolabeling revealed that the association of BP and GT caused a slight disturbance in OPG/RANKL system and retarded Runx-2 labeling.	Benzo(a)pyrene	48-50	TNF superfamily member 11	Rattus norvegicus	93-98
27930925-8	2017	Immunolabeling revealed that the association of BP and GT caused a slight disturbance in OPG/RANKL system and retarded Runx-2 labeling.	Benzo(a)pyrene	48-50	RUNX family transcription factor 2	Rattus norvegicus	119-125
27099206-1	2017	The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAHs of varying carcinogenic activity.	Benzo(a)pyrene	196-210	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	104-108
28043741-9	2017	The expression of several decidualization-related factors, including FOXO1, HoxA10, and BMP2, were altered after BaP treatment.	Benzo(a)pyrene	113-116	forkhead box O1	Mus musculus	69-74
28043741-9	2017	The expression of several decidualization-related factors, including FOXO1, HoxA10, and BMP2, were altered after BaP treatment.	Benzo(a)pyrene	113-116	homeobox A10	Mus musculus	76-82
28043741-9	2017	The expression of several decidualization-related factors, including FOXO1, HoxA10, and BMP2, were altered after BaP treatment.	Benzo(a)pyrene	113-116	bone morphogenetic protein 2	Mus musculus	88-92
28043741-10	2017	BaP reduced the expression of cluster designation 34 (CD34), which indicated that the decidual angiogenesis was inhibited by BaP treatment.	Benzo(a)pyrene	0-3	CD34 antigen	Mus musculus	30-52
28043741-10	2017	BaP reduced the expression of cluster designation 34 (CD34), which indicated that the decidual angiogenesis was inhibited by BaP treatment.	Benzo(a)pyrene	0-3	CD34 antigen	Mus musculus	54-58
28043741-10	2017	BaP reduced the expression of cluster designation 34 (CD34), which indicated that the decidual angiogenesis was inhibited by BaP treatment.	Benzo(a)pyrene	125-128	CD34 antigen	Mus musculus	30-52
28043741-10	2017	BaP reduced the expression of cluster designation 34 (CD34), which indicated that the decidual angiogenesis was inhibited by BaP treatment.	Benzo(a)pyrene	125-128	CD34 antigen	Mus musculus	54-58
27099206-7	2017	In conclusion, it has been demonstrated that the benzo[a]pyrene-mediated upregulation of CYP1, at the mRNA and activity levels, is synergistically and antagonistically modulated by other PAHs.	Benzo(a)pyrene	49-63	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	89-93
27894210-6	2017	Treatment of HELF cells with BaP alone significantly increased the level of Malondialdehyde (MDA) and decreased superoxide dismutase (SOD) and catalase (CAT).	Benzo(a)pyrene	29-32	catalase	Homo sapiens	143-151
28043741-11	2017	In addition, BaP induced the downregulation of vascular endothelial growth factor A.	Benzo(a)pyrene	13-16	vascular endothelial growth factor A	Mus musculus	47-83
28007926-4	2017	BaP-induced Cyp1a1 and Cyp1b1 mRNA levels were higher 4 hours after dosing at noon than at 4 hours after dosing at midnight, and this corresponded with parallel changes in Per gene expression.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	12-18
28007926-4	2017	BaP-induced Cyp1a1 and Cyp1b1 mRNA levels were higher 4 hours after dosing at noon than at 4 hours after dosing at midnight, and this corresponded with parallel changes in Per gene expression.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	23-29
28007926-6	2017	Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts.	Benzo(a)pyrene	199-202	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	12-18
28007926-6	2017	Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts.	Benzo(a)pyrene	199-202	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	23-29
28007926-6	2017	Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts.	Benzo(a)pyrene	225-228	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	12-18
28007926-6	2017	Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts.	Benzo(a)pyrene	225-228	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	23-29
28007926-7	2017	The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands.	Benzo(a)pyrene	91-94	aryl-hydrocarbon receptor	Mus musculus	32-57
28007926-7	2017	The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands.	Benzo(a)pyrene	121-124	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	133-139
28007926-7	2017	The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands.	Benzo(a)pyrene	121-124	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	144-150
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	interleukin 6	Rattus norvegicus	59-63
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	interleukin 6	Rattus norvegicus	65-78
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	tumor necrosis factor	Rattus norvegicus	81-90
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	tumor necrosis factor	Rattus norvegicus	92-119
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	caspase 3	Rattus norvegicus	122-131
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	BCL2, apoptosis regulator	Rattus norvegicus	136-141
28115713-2	2017	One of the most carcinogenic PAHs, benzo(a)pyrene (BaP), is efficiently bound to and transported with atmospheric particles.	Benzo(a)pyrene	35-49	prohibitin 2	Homo sapiens	51-54
27810545-9	2017	Benzo[k]fluoranthene, dibenz[a,h]anthracene, and benzo[b]fluoranthene were the major AhR agonists, explaining approximately 30% of the bioassay-derived benzo[a]pyrene equivalent concentration (BaP-EQ).	Benzo(a)pyrene	152-166	aryl hydrocarbon receptor	Homo sapiens	85-88
28065385-5	2017	Using molecular dynamic simulation, we have shown that in the complex of APE1 with the AP+3-BP-DNA, the BP residue is located within the DNA bend induced by APE1 and contacts the amino acids in the enzyme catalytic center and the catalytic metal ion.	Benzo(a)pyrene	92-94	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	73-77
28065385-5	2017	Using molecular dynamic simulation, we have shown that in the complex of APE1 with the AP+3-BP-DNA, the BP residue is located within the DNA bend induced by APE1 and contacts the amino acids in the enzyme catalytic center and the catalytic metal ion.	Benzo(a)pyrene	92-94	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	157-161
28059605-11	2017	In conclusion, hypermethylation of the CTNNA1 and MYH2 genes in tight junction pathway is associated with the risk for NTDs, and the DNA methylation aberration may be caused by exposure to benzo(a)pyrene.	Benzo(a)pyrene	189-203	catenin (cadherin associated protein), alpha 1	Mus musculus	39-45
28059605-11	2017	In conclusion, hypermethylation of the CTNNA1 and MYH2 genes in tight junction pathway is associated with the risk for NTDs, and the DNA methylation aberration may be caused by exposure to benzo(a)pyrene.	Benzo(a)pyrene	189-203	myosin, heavy polypeptide 2, skeletal muscle, adult	Mus musculus	50-54
27894210-6	2017	Treatment of HELF cells with BaP alone significantly increased the level of Malondialdehyde (MDA) and decreased superoxide dismutase (SOD) and catalase (CAT).	Benzo(a)pyrene	29-32	catalase	Homo sapiens	153-156
28270083-2	2017	OBJECTIVE: The objective of this study is to determine whether ferulenol has an anticancer effect by regulation the Bcl2 protein expression in lung cancer induced by benzo[a]pyrene in Wistar rats.	Benzo(a)pyrene	166-180	BCL2, apoptosis regulator	Rattus norvegicus	116-120
27740625-0	2017	Long-term exposure to bisphenol A or benzo(a)pyrene alters the fate of human mammary epithelial stem cells in response to BMP2 and BMP4, by pre-activating BMP signaling.	Benzo(a)pyrene	37-51	bone morphogenetic protein 2	Homo sapiens	122-126
27740625-0	2017	Long-term exposure to bisphenol A or benzo(a)pyrene alters the fate of human mammary epithelial stem cells in response to BMP2 and BMP4, by pre-activating BMP signaling.	Benzo(a)pyrene	37-51	bone morphogenetic protein 4	Homo sapiens	131-135
27740625-0	2017	Long-term exposure to bisphenol A or benzo(a)pyrene alters the fate of human mammary epithelial stem cells in response to BMP2 and BMP4, by pre-activating BMP signaling.	Benzo(a)pyrene	37-51	bone morphogenetic protein 1	Homo sapiens	122-125
28448190-7	2017	Serum leptin levels elevated with increasing BP values.	Benzo(a)pyrene	45-47	leptin	Homo sapiens	6-12
27894903-6	2017	Here we report the structure of polkappa captured at the lesion-extension stage: the enzyme is extending the primer strand after the base pair containing the BP-dG adduct in the template strand at the -1 position.	Benzo(a)pyrene	158-160	DNA polymerase lambda	Homo sapiens	32-40
28006013-6	2016	Aflatoxin B1 and benzo(a)pyrene were predominantly detected by the CYP3A4 + RAD54 system, while N-nitrosodimethylamine only moderately activated the CYP2B6 + RAD54 reporter system and none of them was identified by the CYP2D6 + RAD54 system.	Benzo(a)pyrene	17-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73
27720465-5	2017	HaCaT cells, which are a human keratinocyte cell line, and normal human epidermal keratinocytes were stimulated with benzo[a]pyrene to induce AHR activation, and the effects of traditional Japanese Kampo herbal formulae were analyzed.	Benzo(a)pyrene	117-131	aryl hydrocarbon receptor	Homo sapiens	142-145
29317995-7	2017	Gene expression levels demonstrated higher expression of transcripts involved in endothelial junction formation, including TJP2 and CDH5, in the BP model.	Benzo(a)pyrene	145-147	tight junction protein 2	Homo sapiens	123-127
29317995-7	2017	Gene expression levels demonstrated higher expression of transcripts involved in endothelial junction formation, including TJP2 and CDH5, in the BP model.	Benzo(a)pyrene	145-147	cadherin 5	Homo sapiens	132-136
30303650-8	2017	In addition, the highest Klotho serum levels were observed in patients whose target BP values were achieved with angiotensin receptor blockers (ARB) compared to those who used other drugs [r&lt;0,01] or failed to reached target BP levels [p=0,008].	Benzo(a)pyrene	84-86	klotho	Homo sapiens	25-31
29104317-0	2017	Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems.	Benzo(a)pyrene	63-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-39
29104317-1	2017	Abstract: Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP).	Benzo(a)pyrene	113-127	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	10-35
29104317-1	2017	Abstract: Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP).	Benzo(a)pyrene	129-132	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	10-35
29104317-8	2017	Two BaP-derived DNA adducts were generated by the CYP1A1-Supersomes, both in the presence of NADPH and NADH, whereas NADPH but not NADH was able to support this reaction in the CYP1A1-Bactosomes.	Benzo(a)pyrene	4-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
29104317-8	2017	Two BaP-derived DNA adducts were generated by the CYP1A1-Supersomes, both in the presence of NADPH and NADH, whereas NADPH but not NADH was able to support this reaction in the CYP1A1-Bactosomes.	Benzo(a)pyrene	4-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	177-183
29104317-10	2017	Our study demonstrates different catalytic efficiencies of CYP1A1 expressed in prokaryotic and eukaryotic cells in BaP bioactivation indicating some limitations in the use of E. coli cells for such studies.	Benzo(a)pyrene	115-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
29181036-1	2017	Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA.	Benzo(a)pyrene	68-83	prohibitin 2	Mus musculus	85-88
27633980-0	2017	Mechanistic Evaluation of Benzo[a]pyrene"s Developmental Toxicities Mediated by Reduced Cyp19a1b Activity.	Benzo(a)pyrene	26-40	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	88-96
27633980-3	2017	We hypothesized that some of the adverse outcomes of early developmental exposure to BaP are the result of reduced Cyp19a1b activity.	Benzo(a)pyrene	85-88	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	115-123
27633980-8	2017	BaP significantly decreased cyp19a1b gene expression in 96 hpf zebrafish larvae homogenates.	Benzo(a)pyrene	0-3	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	28-36
27633980-15	2017	Our results indicate that certain BaP-mediated adverse developmental outcomes were mechanistically in accordance with BaP-mediated Cyp19a1b inhibition.	Benzo(a)pyrene	34-37	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	131-139
27633980-15	2017	Our results indicate that certain BaP-mediated adverse developmental outcomes were mechanistically in accordance with BaP-mediated Cyp19a1b inhibition.	Benzo(a)pyrene	118-121	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	131-139
27800707-0	2017	Characterization of Tilapia (Oreochromis niloticus) aldehyde reductase (AKR1A1) gene, promoter and expression pattern in benzo-a-pyrene exposed fish.	Benzo(a)pyrene	121-135	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	72-78
27800707-1	2017	This study planned to isolation and characterization of AKR1A1 cDNA from Bap injected nile tilapia (Oreochromis niloticus), comparison of its characteristic structures with those of other species, characterization of AKR1A1 gene and promoter, and investigation of AKR1A1 mRNA expression in various organs of Bap injected tilapia.	Benzo(a)pyrene	73-76	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	56-62
27800707-1	2017	This study planned to isolation and characterization of AKR1A1 cDNA from Bap injected nile tilapia (Oreochromis niloticus), comparison of its characteristic structures with those of other species, characterization of AKR1A1 gene and promoter, and investigation of AKR1A1 mRNA expression in various organs of Bap injected tilapia.	Benzo(a)pyrene	308-311	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	56-62
27800707-9	2017	In conclusion, our results concluded that tilapia AKR1A1 is inducible by BaP and have a significant function in the metabolism of xenobiotics and, therefore, may used as biomarker in fish.	Benzo(a)pyrene	73-76	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	50-56
27863410-6	2016	Significantly increased expression of STIM1 mRNA and protein was observed in 16HBE-benzo(a)pyrene (BaP) cells and in BaP-treated mice lung tissues compared with 16HBE-control cells and the control group, respectively.	Benzo(a)pyrene	83-97	stromal interaction molecule 1	Mus musculus	38-43
28263535-4	2016	METHODS: Changes in CYP protein expression after exposure of rats to BaP, EE2 or estradiol were analyzed by Western blotting.	Benzo(a)pyrene	69-72	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	20-23
28263535-6	2016	RESULTS: Whereas exposure to BaP induces expression of CYP1A1 protein and its marker activity (Sudan I oxidation) in liver, kidney and lung of rats, no significant induction of this CYP and its enzyme activity was produced by EE2 and estradiol.	Benzo(a)pyrene	29-32	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	55-61
28263535-6	2016	RESULTS: Whereas exposure to BaP induces expression of CYP1A1 protein and its marker activity (Sudan I oxidation) in liver, kidney and lung of rats, no significant induction of this CYP and its enzyme activity was produced by EE2 and estradiol.	Benzo(a)pyrene	29-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	55-58
28263535-7	2016	Treatment of BaP in combination with EE2 and/or estradiol decreased the BaP-mediated CYP1A1 induction in liver of exposed rats.	Benzo(a)pyrene	13-16	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	85-91
28263535-7	2016	Treatment of BaP in combination with EE2 and/or estradiol decreased the BaP-mediated CYP1A1 induction in liver of exposed rats.	Benzo(a)pyrene	72-75	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	85-91
28263535-8	2016	BaP also induces CYP2C11 protein in rat liver and kidney, but does not increase its enzyme activity measured as testosterone 16alpha-hydroxylation.	Benzo(a)pyrene	0-3	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	17-24
28263535-9	2016	The enzyme activity of another enzyme of the 2C subfamily, CYP2C6, diclofenac 4"-hydroxylation, is even decreased by BaP.	Benzo(a)pyrene	117-120	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	59-65
28263535-12	2016	Whereas only a slight increase in CYP3A protein expression was found by BaP in rat liver, its enzyme activity, testosterone 6beta-hydroxyalation, increased significantly in this organ.	Benzo(a)pyrene	72-75	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	34-39
27849171-6	2016	Furthermore, ligand activation of AhR by the smoke toxin benzo[a]pyrene accelerated osteoclast differentiation in a receptor-dependent manner, and AhR-dependent regulation of mitochondrial biogenesis in osteoclasts was observed.	Benzo(a)pyrene	57-71	aryl-hydrocarbon receptor	Mus musculus	34-37
28006013-6	2016	Aflatoxin B1 and benzo(a)pyrene were predominantly detected by the CYP3A4 + RAD54 system, while N-nitrosodimethylamine only moderately activated the CYP2B6 + RAD54 reporter system and none of them was identified by the CYP2D6 + RAD54 system.	Benzo(a)pyrene	17-31	DNA-dependent ATPase RAD54	Saccharomyces cerevisiae S288C	76-81
28831439-12	2017	CONCLUSION: Of the 21 tumors considered clinically HER2 positive, only four were HER2-enriched subtype with BP, indicating an overestimation of HER2 positivity.	Benzo(a)pyrene	108-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	81-85
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	46-60	damage specific DNA binding protein 2	Homo sapiens	352-356
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	46-60	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	358-361
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	46-60	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	363-366
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	46-60	ERCC excision repair 5, endonuclease	Homo sapiens	368-371
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	132-137	damage specific DNA binding protein 2	Homo sapiens	352-356
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	132-137	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	358-361
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	132-137	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	363-366
27694624-2	2016	Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the DNA repair genes DDB2, XPC, XPF, XPG and POLH.	Benzo(a)pyrene	132-137	ERCC excision repair 5, endonuclease	Homo sapiens	368-371
27482608-13	2016	ABBREVIATIONS: ALP = alkaline phosphatase beta-CTX = cross-linked C-telopeptide of type I collagen BMD = bone mineral density BP = bisphosphonate DXA = dual-energy X-ray absorptiometry 25OHD = 25-hydroxyvitamin D OI = osteogenesis imperfecta PTH = parathyroid hormone.	Benzo(a)pyrene	126-128	alkaline phosphatase, placental	Homo sapiens	15-18
27121444-4	2016	The achieved changes in BP were analyzed for their association with genotypes at ACE2 gene loci.	Benzo(a)pyrene	24-26	angiotensin converting enzyme 2	Homo sapiens	81-85
26738610-9	2016	CONCLUSIONS: The present results suggest that BaP exerts inhibitory effects on the maintenance of homeostasis in HPDL tissue, such as osteoblastic differentiation and collagen synthesis of HPDLCs, and that this signaling pathway could be suppressed by preventing the transactivity of AhR.	Benzo(a)pyrene	46-49	aryl hydrocarbon receptor	Homo sapiens	284-287
28831439-12	2017	CONCLUSION: Of the 21 tumors considered clinically HER2 positive, only four were HER2-enriched subtype with BP, indicating an overestimation of HER2 positivity.	Benzo(a)pyrene	108-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	81-85
27931821-6	2016	In the treatment groups receiving 150mg/kg of BP or more, both the RBC Pig-a assay and the PIGRET assay detected the in vivo mutagenicity of BP.	Benzo(a)pyrene	46-48	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	71-76
27376790-16	2016	Our experimental data suggest that boosting of Mal d 1 recognizing immunoglobulins by BP SCIT is important for the amelioration of apple allergy in human.	Benzo(a)pyrene	86-88	major allergen Mal d 1	Malus domestica	47-54
25946486-7	2016	These results demonstrated that the Nrf2-ARE pathway plays an important role in Sch B attenuating BaP-induced HTR cells damages in vitro.	Benzo(a)pyrene	98-101	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
27601158-0	2016	Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	92-117
27601158-0	2016	Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	122-125
27601158-0	2016	Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc.	Benzo(a)pyrene	0-14	matrix metallopeptidase 9	Homo sapiens	149-153
27601158-0	2016	Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc.	Benzo(a)pyrene	0-14	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
27601158-2	2016	Benzo[a]pyrene (BaP), a Group I carcinogen categorized by the IARC, is a cumulative foodborne carcinogen and ubiquitous environmental pollutant with potent carcinogenic properties.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
26918773-9	2016	Ex vivo studies showed that co-exposure to OVA and BaP activated the MHC class II and CD86 expression in MLN cells.	Benzo(a)pyrene	51-54	CD86 antigen	Mus musculus	86-90
26918773-10	2016	Exposure to BaP with OVA increased IL-4, IL-5 and interferon gamma levels in culture supernatants of OVA-re-stimulated MLN cells.	Benzo(a)pyrene	12-15	interleukin 4	Mus musculus	35-39
26918773-10	2016	Exposure to BaP with OVA increased IL-4, IL-5 and interferon gamma levels in culture supernatants of OVA-re-stimulated MLN cells.	Benzo(a)pyrene	12-15	interleukin 5	Mus musculus	41-45
26918773-11	2016	In conclusion, low-dose BaP can, at least in part, enhance allergic airway inflammation by facilitating Th2 responses and activating MLN cells; a high BaP dose may contribute to activating both Th1 and Th2 responses.	Benzo(a)pyrene	24-27	heart and neural crest derivatives expressed 2	Mus musculus	104-107
26918773-11	2016	In conclusion, low-dose BaP can, at least in part, enhance allergic airway inflammation by facilitating Th2 responses and activating MLN cells; a high BaP dose may contribute to activating both Th1 and Th2 responses.	Benzo(a)pyrene	24-27	negative elongation factor complex member C/D, Th1l	Mus musculus	194-197
26918773-11	2016	In conclusion, low-dose BaP can, at least in part, enhance allergic airway inflammation by facilitating Th2 responses and activating MLN cells; a high BaP dose may contribute to activating both Th1 and Th2 responses.	Benzo(a)pyrene	151-154	negative elongation factor complex member C/D, Th1l	Mus musculus	194-197
26918773-11	2016	In conclusion, low-dose BaP can, at least in part, enhance allergic airway inflammation by facilitating Th2 responses and activating MLN cells; a high BaP dose may contribute to activating both Th1 and Th2 responses.	Benzo(a)pyrene	151-154	heart and neural crest derivatives expressed 2	Mus musculus	202-205
26609631-4	2016	Here, we show that benzo[a]pyrene diol epoxide (BPDE, the active metabolite of cigarette smoke carcinogen benzo[a]pyrene)-induced human bronchial epithelial cell (HBEC) transformation was enhanced by IL-6 in vitro.	Benzo(a)pyrene	19-33	interleukin 6	Homo sapiens	200-204
27573671-7	2016	Environmental AHR ligands 2,3,7,8-tetrachlorodibenzo[p]dioxin and benzo[a]pyrene mimic this effect.	Benzo(a)pyrene	66-80	aryl hydrocarbon receptor	Homo sapiens	14-17
27544633-1	2016	The aryl hydrocarbon receptor (AhR) is the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene (BaP) and other exogenous compounds.	Benzo(a)pyrene	100-114	aryl hydrocarbon receptor	Homo sapiens	4-29
27544633-1	2016	The aryl hydrocarbon receptor (AhR) is the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene (BaP) and other exogenous compounds.	Benzo(a)pyrene	100-114	aryl hydrocarbon receptor	Homo sapiens	31-34
27544633-1	2016	The aryl hydrocarbon receptor (AhR) is the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene (BaP) and other exogenous compounds.	Benzo(a)pyrene	116-119	aryl hydrocarbon receptor	Homo sapiens	4-29
27544633-1	2016	The aryl hydrocarbon receptor (AhR) is the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), benzo(a)pyrene (BaP) and other exogenous compounds.	Benzo(a)pyrene	116-119	aryl hydrocarbon receptor	Homo sapiens	31-34
27544633-2	2016	In human sebocytes, TCDD and BaP were found to activate the expression of multiple genes, including cytochrome P450 1A1 (CYP1A1), and inhibit lipid synthesis via AhR, while little is known about endogenous functions of the AhR.	Benzo(a)pyrene	29-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-119
27544633-2	2016	In human sebocytes, TCDD and BaP were found to activate the expression of multiple genes, including cytochrome P450 1A1 (CYP1A1), and inhibit lipid synthesis via AhR, while little is known about endogenous functions of the AhR.	Benzo(a)pyrene	29-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-127
27544633-2	2016	In human sebocytes, TCDD and BaP were found to activate the expression of multiple genes, including cytochrome P450 1A1 (CYP1A1), and inhibit lipid synthesis via AhR, while little is known about endogenous functions of the AhR.	Benzo(a)pyrene	29-32	aryl hydrocarbon receptor	Homo sapiens	162-165
27544633-2	2016	In human sebocytes, TCDD and BaP were found to activate the expression of multiple genes, including cytochrome P450 1A1 (CYP1A1), and inhibit lipid synthesis via AhR, while little is known about endogenous functions of the AhR.	Benzo(a)pyrene	29-32	aryl hydrocarbon receptor	Homo sapiens	223-226
27211013-2	2016	Moderately strong AHR agonists, for example benzo[a]pyrene and beta-naphthoflavone, are capable of causing similar cardiotoxic effects, particularly when coupled with cytochrome P450 1A (CYP1A) inhibitors (e.g., fluoranthene (FL).	Benzo(a)pyrene	44-58	cytochrome P450 1A1	Fundulus heteroclitus	167-185
27211013-2	2016	Moderately strong AHR agonists, for example benzo[a]pyrene and beta-naphthoflavone, are capable of causing similar cardiotoxic effects, particularly when coupled with cytochrome P450 1A (CYP1A) inhibitors (e.g., fluoranthene (FL).	Benzo(a)pyrene	44-58	cytochrome P450 1A1	Fundulus heteroclitus	187-192
27095601-0	2016	Ubiquitin Protein Ligase Ring2 Is Involved in S-phase Checkpoint and DNA Damage in Cells Exposed to Benzo[a]pyrene.	Benzo(a)pyrene	100-114	ring finger protein 2	Homo sapiens	25-30
27095601-2	2016	In a series of experiments using wild-type cell (16HBE and WI38) and small interfering RNA (siRNA) Ring2 cells exposed to benzo[a]pyrene (BaP), we evaluated the cell cycle and DNA damage.	Benzo(a)pyrene	122-136	ring finger protein 2	Homo sapiens	99-104
27095601-2	2016	In a series of experiments using wild-type cell (16HBE and WI38) and small interfering RNA (siRNA) Ring2 cells exposed to benzo[a]pyrene (BaP), we evaluated the cell cycle and DNA damage.	Benzo(a)pyrene	138-141	ring finger protein 2	Homo sapiens	99-104
27095601-3	2016	The benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE-DNA) adduct assay demonstrated that in vitro exposure to BaP increased DNA damage in a time- and dose-dependent manner in wild-type and siRNA Ring2 cells.	Benzo(a)pyrene	111-114	ring finger protein 2	Homo sapiens	196-201
27095601-4	2016	Analysis of covariance showed that a decrease of Ring2 caused DNA hypersensitivity to BaP.	Benzo(a)pyrene	86-89	ring finger protein 2	Homo sapiens	49-54
27095601-5	2016	Flow cytometry results and proliferating cell nuclear antigen levels indicated that inhibition of Ring2 attenuated the effect of BaP on S-phase arrest.	Benzo(a)pyrene	129-132	ring finger protein 2	Homo sapiens	98-103
27095601-6	2016	Taken together, these data implied that the lower proportion of cells in the S phase induced by inhibition of Ring2 may play an important role in DNA hypersensitivity to BaP.	Benzo(a)pyrene	170-173	ring finger protein 2	Homo sapiens	110-115
27486223-5	2016	Also relative to human AHR, the Neandertal AHR exhibited 150-1000 times greater sensitivity to induction of Cyp1a1 and Cyp1b1 expression by PAHs (e.g., benzo(a)pyrene).	Benzo(a)pyrene	152-166	aryl hydrocarbon receptor	Homo sapiens	43-46
27486223-5	2016	Also relative to human AHR, the Neandertal AHR exhibited 150-1000 times greater sensitivity to induction of Cyp1a1 and Cyp1b1 expression by PAHs (e.g., benzo(a)pyrene).	Benzo(a)pyrene	152-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	108-114
27486223-5	2016	Also relative to human AHR, the Neandertal AHR exhibited 150-1000 times greater sensitivity to induction of Cyp1a1 and Cyp1b1 expression by PAHs (e.g., benzo(a)pyrene).	Benzo(a)pyrene	152-166	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	119-125
27362771-0	2016	Resolvin D1 down-regulates CYP1A1 and PTGS2 gene in the HUVEC cells treated with benzo(a)pyrene.	Benzo(a)pyrene	81-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	27-33
27684561-7	2016	RESULTS: Of the five PAHs tested, after chronic treatment only BaP (100 nM) showed a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity.	Benzo(a)pyrene	63-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-133
27684561-7	2016	RESULTS: Of the five PAHs tested, after chronic treatment only BaP (100 nM) showed a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity.	Benzo(a)pyrene	63-66	superoxide dismutase 1	Homo sapiens	141-145
27684561-7	2016	RESULTS: Of the five PAHs tested, after chronic treatment only BaP (100 nM) showed a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity.	Benzo(a)pyrene	63-66	catalase	Homo sapiens	150-158
27684561-7	2016	RESULTS: Of the five PAHs tested, after chronic treatment only BaP (100 nM) showed a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity.	Benzo(a)pyrene	63-66	caspase 3	Homo sapiens	177-186
27684561-8	2016	However, acute treatment with BaP showed only an increase in the mRNA expression of CYP1A1.	Benzo(a)pyrene	30-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	84-90
27684561-9	2016	CONCLUSIONS: These results suggest that of the five PAHs tested, BaP is the major contributor to the toxic effect of PAHs in monocytic cells, which is likely to occur through CYP and oxidative stress pathways.	Benzo(a)pyrene	65-68	peptidylprolyl isomerase G	Homo sapiens	175-178
27575721-0	2016	Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	Benzo(a)pyrene	169-183	cytochrome b5 type A	Homo sapiens	19-32
27575721-0	2016	Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	Benzo(a)pyrene	169-183	cytochrome b5 type A	Homo sapiens	47-60
27575721-0	2016	Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	Benzo(a)pyrene	169-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-121
27607467-0	2016	Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes.	Benzo(a)pyrene	36-50	catalase	Mus musculus	18-26
27607467-1	2016	UNLABELLED: We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs).	Benzo(a)pyrene	143-157	catalase	Mus musculus	58-66
29964791-6	2016	Compared with soil screening value of Beijing contaminated industrial sites, only part of the sample points exceeded the standard, typically benzo[a]anthracene(BaA) and benzo[a]pyrene(BaP).	Benzo(a)pyrene	169-183	prohibitin 2	Homo sapiens	184-187
29964791-9	2016	The carcinogenic risk value of benzo[a]pyrene(BaP) was the biggest among the 16 PAHs.	Benzo(a)pyrene	31-45	prohibitin 2	Homo sapiens	46-49
27329536-8	2016	The highest expression of cyclooxygenase (COX-2) and cannabinoid receptor 2 (CB2) was noted in macrophages supplemented with DHA and activated with LPS and BaP.	Benzo(a)pyrene	156-159	cytochrome c oxidase II, mitochondrial	Mus musculus	42-47
27329536-8	2016	The highest expression of cyclooxygenase (COX-2) and cannabinoid receptor 2 (CB2) was noted in macrophages supplemented with DHA and activated with LPS and BaP.	Benzo(a)pyrene	156-159	cannabinoid receptor 2 (macrophage)	Mus musculus	53-75
27329536-8	2016	The highest expression of cyclooxygenase (COX-2) and cannabinoid receptor 2 (CB2) was noted in macrophages supplemented with DHA and activated with LPS and BaP.	Benzo(a)pyrene	156-159	cannabinoid receptor 2 (macrophage)	Mus musculus	77-80
27329536-9	2016	Our data suggested a novel, CB2 receptor-dependent, environmental stress reaction in macrophages co-treated with LPS and BaP after supplementation with DHA.	Benzo(a)pyrene	121-124	cannabinoid receptor 2 (macrophage)	Mus musculus	28-31
26438400-0	2016	Inflammation-associated extracellular beta-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene.	Benzo(a)pyrene	110-124	glucuronidase beta	Homo sapiens	38-56
26438400-2	2016	Since inflammation is associated with carcinogenesis, we investigated how extracellular beta-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P).	Benzo(a)pyrene	173-187	glucuronidase beta	Homo sapiens	88-106
27709387-1	2016	We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity.	Benzo(a)pyrene	138-140	angiotensin I converting enzyme	Rattus norvegicus	23-52
27338711-0	2016	Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice.	Benzo(a)pyrene	0-14	catenin (cadherin associated protein), beta 1	Mus musculus	130-142
27362771-0	2016	Resolvin D1 down-regulates CYP1A1 and PTGS2 gene in the HUVEC cells treated with benzo(a)pyrene.	Benzo(a)pyrene	81-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-43
27362771-5	2016	RESULTS: RvD1 down-regulates cytochrome P450 (CYP1A1) and prostaglandin synthase 2 (PTGS2) gene expression in HUVEC cells exposed to BaP.	Benzo(a)pyrene	133-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	46-52
27362771-5	2016	RESULTS: RvD1 down-regulates cytochrome P450 (CYP1A1) and prostaglandin synthase 2 (PTGS2) gene expression in HUVEC cells exposed to BaP.	Benzo(a)pyrene	133-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-82
27362771-5	2016	RESULTS: RvD1 down-regulates cytochrome P450 (CYP1A1) and prostaglandin synthase 2 (PTGS2) gene expression in HUVEC cells exposed to BaP.	Benzo(a)pyrene	133-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-89
27362771-6	2016	Repressesion of COX-2, cPGES and overexpressesion of GSTM1 protein was noted after co-treatment with RvD1 and BaP.	Benzo(a)pyrene	110-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-21
27362771-6	2016	Repressesion of COX-2, cPGES and overexpressesion of GSTM1 protein was noted after co-treatment with RvD1 and BaP.	Benzo(a)pyrene	110-113	glutathione S-transferase mu 1	Homo sapiens	53-58
27374118-6	2016	The primary action of TEN on BP lowering was due to restoring the AngII-induced manifestation of congestive heart failure observed in SHR.	Benzo(a)pyrene	29-31	angiotensinogen	Rattus norvegicus	66-71
27180599-8	2016	Occupational status, geographical origin, BMI and the use of angiotensin converting enzyme (ACE) inhibitors were found to be the determinants of office BP control (p&lt;0.05, p&lt;0.05, p=0.001 and p&lt;0.05, respectively), and BMI and grade 3-4 retinopathy findings were found to be the determinants of home BP control (p &lt;0.05 for both).	Benzo(a)pyrene	152-154	angiotensin I converting enzyme	Homo sapiens	61-90
27196671-5	2016	We then exposed cells to either binary mixtures of the highly genotoxic benzo[a]pyrene (B[a]P) with each PAH or complex mixtures of all studied PAHs mimicking by real emissions including combustion of wood, cigarette smoke, and atmospheres of garage, silicon factory and urban environments.	Benzo(a)pyrene	72-86	phenylalanine hydroxylase	Homo sapiens	105-108
27274088-2	2016	APEX2 fused to a protein of interest covalently tags nearby proteins with biotin-phenol (BP) when H2O2 is added to the cell culture medium.	Benzo(a)pyrene	89-91	apurinic/apyrimidinic endodeoxyribonuclease 2	Homo sapiens	0-5
27404282-0	2016	NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	Benzo(a)pyrene	155-169	cytochrome b5 type A	Homo sapiens	5-18
27404282-0	2016	NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	Benzo(a)pyrene	155-169	cytochrome b5 type A	Homo sapiens	33-46
27404282-0	2016	NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	Benzo(a)pyrene	155-169	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-107
27404282-1	2016	Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after activation by cytochrome P450 (P450).	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
27551266-0	2016	Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol.	Benzo(a)pyrene	0-14	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
27488617-0	2016	The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival.	Benzo(a)pyrene	29-43	solute carrier family 9 member A1	Homo sapiens	104-108
27608907-7	2016	On the other hand, protein expressions of acetylated (lys382)-p53 were significantly decreased, following BP treatment.	Benzo(a)pyrene	106-108	transformation related protein 53, pseudogene	Mus musculus	62-65
27608907-9	2016	Moreover, BP treatment brought about a significant increase in the activity of COX-2.	Benzo(a)pyrene	10-12	prostaglandin-endoperoxide synthase 2	Mus musculus	79-84
27608907-10	2016	Supplementation of zinc to BP treated mice stimulated acetylation of p53 as observed by an increase in the protein expression of acetylated (lys382)-p53.	Benzo(a)pyrene	27-29	transformation related protein 53, pseudogene	Mus musculus	69-72
27608907-10	2016	Supplementation of zinc to BP treated mice stimulated acetylation of p53 as observed by an increase in the protein expression of acetylated (lys382)-p53.	Benzo(a)pyrene	27-29	transformation related protein 53, pseudogene	Mus musculus	149-152
26712527-8	2016	Although these mice also exhibited deficient NCC activity, NCC could be stimulated by restricting dietary potassium, which also returned BP to control levels.	Benzo(a)pyrene	137-139	solute carrier family 12, member 3	Mus musculus	59-62
27162022-0	2016	Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling.	Benzo(a)pyrene	24-38	mitogen-activated protein kinase 14	Homo sapiens	100-103
27162022-0	2016	Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling.	Benzo(a)pyrene	24-38	activating transcription factor 2	Homo sapiens	109-113
27162022-0	2016	Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling.	Benzo(a)pyrene	24-38	nitric oxide synthase 2	Homo sapiens	114-118
27162022-7	2016	Resveratrol also down-regulated B(a)P-induced testicular iNOS production through suppressing the activation of p38 MAPK and ATF2, thus improved the oxidative status of the testis and prevented apoptosis.	Benzo(a)pyrene	32-37	nitric oxide synthase 2	Homo sapiens	57-61
27162022-7	2016	Resveratrol also down-regulated B(a)P-induced testicular iNOS production through suppressing the activation of p38 MAPK and ATF2, thus improved the oxidative status of the testis and prevented apoptosis.	Benzo(a)pyrene	32-37	mitogen-activated protein kinase 14	Homo sapiens	111-114
27162022-7	2016	Resveratrol also down-regulated B(a)P-induced testicular iNOS production through suppressing the activation of p38 MAPK and ATF2, thus improved the oxidative status of the testis and prevented apoptosis.	Benzo(a)pyrene	32-37	activating transcription factor 2	Homo sapiens	124-128
27162022-8	2016	Our findings cumulatively suggest that resveratrol inhibits conversion of B(a)P into BPDE by modulating the transcriptional regulation of CYP1A1 and acting as an antioxidant thus prevents B(a)P-induced oxidative stress and testicular apoptosis.	Benzo(a)pyrene	74-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	138-144
27180599-8	2016	Occupational status, geographical origin, BMI and the use of angiotensin converting enzyme (ACE) inhibitors were found to be the determinants of office BP control (p&lt;0.05, p&lt;0.05, p=0.001 and p&lt;0.05, respectively), and BMI and grade 3-4 retinopathy findings were found to be the determinants of home BP control (p &lt;0.05 for both).	Benzo(a)pyrene	152-154	angiotensin I converting enzyme	Homo sapiens	92-95
27139774-0	2016	The ERCC2/XPD Lys751Gln polymorphism affects DNA repair of benzo[a]pyrene induced damage, tested in an in vitro model.	Benzo(a)pyrene	59-73	general transcription and DNA repair factor IIH helicase subunit XPD	Cricetulus griseus	4-9
27139774-0	2016	The ERCC2/XPD Lys751Gln polymorphism affects DNA repair of benzo[a]pyrene induced damage, tested in an in vitro model.	Benzo(a)pyrene	59-73	general transcription and DNA repair factor IIH helicase subunit XPD	Cricetulus griseus	10-13
27208085-7	2016	Treatment with BaP elevated the expression of BAX protein at 6 h and activated downstream caspases-9 and -3 at 24 h in a concentration-dependent manner in germ cells of fetal ovaries.	Benzo(a)pyrene	15-18	BCL2-associated X protein	Mus musculus	46-49
27208085-10	2016	Our findings show that BaP exposure increases caspase-dependent and BAX-associated germ cell apoptosis in the mouse fetal ovary, leading to germ cell depletion.	Benzo(a)pyrene	23-26	BCL2-associated X protein	Mus musculus	68-71
28116098-10	2016	This AhR-dependent progenitor recovery with BP induction accounts for the absence of suppression of B220+ BM and spleen populations at 48-168 h. However, DMBA and BP produced similar profiles for thymus cell suppression, independent of AhR genotype.	Benzo(a)pyrene	44-46	aryl-hydrocarbon receptor	Mus musculus	5-8
27266337-2	2016	Four hydroxy metabolites of known and suspected carcinogenic PAHs (benzo[a]pyrene (B[a]P), benz[a]anthracene (B[a]A), and chrysene (CRY)) were selected as suitable biomarkers of PAH exposure and associated risks to human health.	Benzo(a)pyrene	67-81	phenylalanine hydroxylase	Homo sapiens	61-64
27153234-4	2016	BaP, TCS and the mixture of the two all induced a marked metabolic disorder in the liver highlighted by insulin resistance-like and non-alcoholic fatty liver disease (NAFLD)-like phenotypes together with hepatotoxicity due to the impairment of lipid metabolism.	Benzo(a)pyrene	0-3	insulin	Xenopus tropicalis	104-111
27331345-0	2016	Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.	Benzo(a)pyrene	61-75	aldehyde dehydrogenase 1 family member A1	Homo sapiens	0-26
27331345-1	2016	Recently, Aldehyde dehydrogenase 1A1 (ALDH1A1) has been proposed to be a common marker of cancer stem cells and can be induced by benzo[a]pyrene (B[a]P) exposure.	Benzo(a)pyrene	130-144	aldehyde dehydrogenase 1 family member A1	Homo sapiens	10-36
27331345-1	2016	Recently, Aldehyde dehydrogenase 1A1 (ALDH1A1) has been proposed to be a common marker of cancer stem cells and can be induced by benzo[a]pyrene (B[a]P) exposure.	Benzo(a)pyrene	130-144	aldehyde dehydrogenase 1 family member A1	Homo sapiens	38-45
26359795-0	2016	Benzo(a)pyrene inhibits migration and invasion of extravillous trophoblast HTR-8/SVneo cells via activation of the ERK and JNK pathway.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 8	Homo sapiens	123-126
26359795-9	2016	Further investigations indicated that the protein levels of MMP-2, MMP-9 and E-cadherin in HTR-8/SVneo cells were changed by BaP treatment.	Benzo(a)pyrene	125-128	matrix metallopeptidase 2	Homo sapiens	60-65
26359795-9	2016	Further investigations indicated that the protein levels of MMP-2, MMP-9 and E-cadherin in HTR-8/SVneo cells were changed by BaP treatment.	Benzo(a)pyrene	125-128	matrix metallopeptidase 9	Homo sapiens	67-72
26359795-9	2016	Further investigations indicated that the protein levels of MMP-2, MMP-9 and E-cadherin in HTR-8/SVneo cells were changed by BaP treatment.	Benzo(a)pyrene	125-128	cadherin 1	Homo sapiens	77-87
27034468-0	2016	Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase kappa.	Benzo(a)pyrene	65-79	DNA polymerase kappa	Homo sapiens	96-116
27034468-2	2016	DNA polymerase kappa (polkappa) is the only known Y-family polymerase that bypasses BP-dG accurately and thus protects cells from genotoxic BP.	Benzo(a)pyrene	84-86	DNA polymerase kappa	Homo sapiens	0-20
26238291-1	2016	Benzo(a)pyrene (BaP) is a ubiquitous carcinogen resulting from incomplete combustion of organic compounds and also present at high levels in cigarette smoke.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
26471128-3	2016	We found that haplodeficiency of KL(+/-) in mice increased the plasma level of aldosterone by 16 weeks of age, which coincided with spontaneous and persistent elevation of BP.	Benzo(a)pyrene	172-174	klotho	Mus musculus	33-35
27195522-0	2016	Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene.	Benzo(a)pyrene	108-122	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	63-68
27195522-2	2016	The neurotoxicity of BaP is proposed to arise from either genotoxicity leading to neuronal cell death, or perturbed expression of N-methyl-d-aspartate receptor (NMDAR) subunits.	Benzo(a)pyrene	21-24	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	130-159
27195522-2	2016	The neurotoxicity of BaP is proposed to arise from either genotoxicity leading to neuronal cell death, or perturbed expression of N-methyl-d-aspartate receptor (NMDAR) subunits.	Benzo(a)pyrene	21-24	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	161-166
27195522-11	2016	Overall, we suggest that BaP-induced neurotoxicity is more likely to be a consequence of NMDAR perturbation than genotoxicity, and identify other important genes potentially mediating this adverse outcome.	Benzo(a)pyrene	25-28	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	89-94
27188603-11	2016	The real-time quantitative PCR results showed that the DeltaCT values of ERK mRNA in the model, BL, BM, BH, PD98059 and BP groups were 0.270+-0.084, 0.293+-0.081, 0.596+-0.224, 0.857+-0.183, 0.868+-0.187 and 1.313+-0.282, respectively.	Benzo(a)pyrene	120-122	mitogen-activated protein kinase 1	Mus musculus	73-76
27114244-0	2016	Corrigendum to "BDNF protects pancreatic beta cells (RIN5F) against cytotoxic action of alloxan, streptozotocin, doxorubicin and benzo(a)pyrene in vitro" METABOLISM CLINICAL AND EXPERIMENTAL 65 (2016) 667-684.	Benzo(a)pyrene	129-143	brain derived neurotrophic factor	Homo sapiens	16-20
27188603-12	2016	The DeltaCT values of RSK2 mRNA in the model, BL, BM, BH, PD98059 and BP groups were 0.340+-0.062, 0.337+-0.071, 0.642+-0.226, 0.915+-0.170, 0.923+-0.176 and 1.413+-0.269, respectively.	Benzo(a)pyrene	70-72	ribosomal protein S6 kinase polypeptide 3	Mus musculus	22-26
27188603-15	2016	The protein levels of p-ERK in the model, BL, BM, BH, PD98059 and BP groups were 0.721+-0.094, 0.695+-0.095, 0.555+-0.080, 0.388+-0.052, 0.341+-0.060, 0.235+- 0.056, respectively.	Benzo(a)pyrene	66-68	mitogen-activated protein kinase 1	Mus musculus	24-27
27188603-17	2016	The protein levels of p-RSK2 in the model, BL, BM, BH, PD98059 and BP groups were 0.613+-0.085, 0.612+-0.084, 0.427+-0.089, 0.305+-0.056, 0.258+-0.051, 0.158+-0.058, respectively.	Benzo(a)pyrene	67-69	ribosomal protein S6 kinase polypeptide 3	Mus musculus	24-28
27188603-19	2016	The protein level of GSK3beta in the model, BL, BM, BH, PD98059 and BP groups were increased gradually, while the protein level of p-GSK3beta and p-Bad were decreased gradually.	Benzo(a)pyrene	68-70	glycogen synthase kinase 3 beta	Mus musculus	21-29
27167070-4	2016	Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro.	Benzo(a)pyrene	76-78	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	129-135
27149118-3	2016	BALB/c mice were immunised twice with OLA followed by sensitisation with the major birch pollen (BP) allergen Bet v 1 and an aerosol challenge with BP extract.	Benzo(a)pyrene	97-99	protein tyrosine phosphatase, receptor type, J	Mus musculus	110-113
27293999-0	2016	The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-beta1 signaling: implications in hepatocellular carcinogenesis.	Benzo(a)pyrene	38-52	aryl-hydrocarbon receptor	Mus musculus	4-29
27293999-0	2016	The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-beta1 signaling: implications in hepatocellular carcinogenesis.	Benzo(a)pyrene	38-52	transforming growth factor beta 1	Homo sapiens	105-114
27293999-5	2016	Here we present evidence that reactivation of L1 and modulation of EMT in HepG2 cells by the AhR ligand benzo(a)pyrene (BaP) is effected through the canonical TGF-beta1 signaling pathway.	Benzo(a)pyrene	104-118	aryl hydrocarbon receptor	Homo sapiens	93-96
27293999-5	2016	Here we present evidence that reactivation of L1 and modulation of EMT in HepG2 cells by the AhR ligand benzo(a)pyrene (BaP) is effected through the canonical TGF-beta1 signaling pathway.	Benzo(a)pyrene	104-118	prohibitin 2	Homo sapiens	120-123
27293999-5	2016	Here we present evidence that reactivation of L1 and modulation of EMT in HepG2 cells by the AhR ligand benzo(a)pyrene (BaP) is effected through the canonical TGF-beta1 signaling pathway.	Benzo(a)pyrene	104-118	transforming growth factor beta 1	Homo sapiens	159-168
26919281-3	2016	This study investigated whether SAMC prevented the carcinogen benzo(a)pyrene (B(a)P) from inducing precancerous activity in human lung cells (A549 cell line).	Benzo(a)pyrene	62-76	solute carrier family 25 member 26	Homo sapiens	32-36
26919281-3	2016	This study investigated whether SAMC prevented the carcinogen benzo(a)pyrene (B(a)P) from inducing precancerous activity in human lung cells (A549 cell line).	Benzo(a)pyrene	78-83	solute carrier family 25 member 26	Homo sapiens	32-36
27085775-0	2016	BDNF protects pancreatic beta cells (RIN5F) against cytotoxic action of alloxan, streptozotocin, doxorubicin and benzo(a)pyrene in vitro.	Benzo(a)pyrene	113-127	brain derived neurotrophic factor	Mus musculus	0-4
27085775-1	2016	OBJECTIVE: The study was conducted to observe whether brain-derived neurotrophic factor (BDNF) has cytoprotective actions against alloxan (AL), streptozotocin (STZ), doxorubicin (DB) and benzo(a)pyrene (BP) compounds in vitro that may account for its beneficial action in diabetes mellitus.	Benzo(a)pyrene	187-201	brain derived neurotrophic factor	Mus musculus	54-87
27085775-1	2016	OBJECTIVE: The study was conducted to observe whether brain-derived neurotrophic factor (BDNF) has cytoprotective actions against alloxan (AL), streptozotocin (STZ), doxorubicin (DB) and benzo(a)pyrene (BP) compounds in vitro that may account for its beneficial action in diabetes mellitus.	Benzo(a)pyrene	187-201	brain derived neurotrophic factor	Mus musculus	89-93
27085775-1	2016	OBJECTIVE: The study was conducted to observe whether brain-derived neurotrophic factor (BDNF) has cytoprotective actions against alloxan (AL), streptozotocin (STZ), doxorubicin (DB) and benzo(a)pyrene (BP) compounds in vitro that may account for its beneficial action in diabetes mellitus.	Benzo(a)pyrene	203-205	brain derived neurotrophic factor	Mus musculus	54-87
27085775-1	2016	OBJECTIVE: The study was conducted to observe whether brain-derived neurotrophic factor (BDNF) has cytoprotective actions against alloxan (AL), streptozotocin (STZ), doxorubicin (DB) and benzo(a)pyrene (BP) compounds in vitro that may account for its beneficial action in diabetes mellitus.	Benzo(a)pyrene	203-205	brain derived neurotrophic factor	Mus musculus	89-93
27085775-5	2016	Effect of alloxan, STZ, doxorubicin and BP on the production of BDNF by RIN5F cells was also studied.	Benzo(a)pyrene	40-42	brain derived neurotrophic factor	Mus musculus	64-68
27085775-6	2016	RESULTS: Results of the present study revealed that BDNF in the doses (100ng&gt;50ng&gt;10ng/ml) has significant cytoprotection (P&lt;0.001, P&lt;0.01) on cytotoxic action of AL, STZ, DB and BP against rat insulinoma RIN5F (5x10(4) cells/100mul) cells in vitro.	Benzo(a)pyrene	191-193	brain-derived neurotrophic factor	Rattus norvegicus	52-56
26984301-7	2016	The BMD-covariate approach revealed tissue-specific differences in the induction of lacZ transgene mutations in Muta Mouse specimens exposed to benzo[a]pyrene (BaP), with the results permitting the formulation of mechanistic hypotheses regarding the observed potency ranking.	Benzo(a)pyrene	144-158	prohibitin 2	Mus musculus	160-163
27035420-2	2016	A previous study by our group indicated that NRF-1 is involved in mitochondrial dysfunction induced by the environmental pollutant benzo[a]pyrene in the 16HBE human bronchial epithelial cell line.	Benzo(a)pyrene	131-145	nuclear respiratory factor 1	Homo sapiens	45-50
27167070-4	2016	Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro.	Benzo(a)pyrene	76-78	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	140-146
27167070-4	2016	Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro.	Benzo(a)pyrene	76-78	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	201-207
27167070-5	2016	Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo.	Benzo(a)pyrene	20-22	aryl hydrocarbon receptor	Rattus norvegicus	69-72
27167070-5	2016	Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo.	Benzo(a)pyrene	20-22	POU class 2 homeobox 1	Rattus norvegicus	133-138
27167070-5	2016	Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo.	Benzo(a)pyrene	20-22	CCAAT/enhancer binding protein gamma	Rattus norvegicus	143-173
27167070-5	2016	Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo.	Benzo(a)pyrene	20-22	CCAAT/enhancer binding protein gamma	Rattus norvegicus	175-180
27167070-5	2016	Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo.	Benzo(a)pyrene	20-22	aryl hydrocarbon receptor	Rattus norvegicus	240-243
27167070-6	2016	Expression of another factor involved in downregulation of CYP1A-pAhR repressor (AhRR)-was lower in the liver of the rats treated with BP and menadione, indicating that the inhibitory effect of menadione on CYP1A is not mediated by this protein.	Benzo(a)pyrene	135-137	aryl-hydrocarbon receptor repressor	Rattus norvegicus	81-85
26617012-4	2016	The better extraction efficiency of benzo[a]pyrene (68%) from ground-roasted coffee was achieved with a solvent ratio of Hex:MC (9:1 v/v) and three extraction periods of 20 min, followed by alkaline saponification and purification of the extracts.	Benzo(a)pyrene	36-50	hematopoietically expressed homeobox	Homo sapiens	121-124
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	132-135	tumor protein p53	Homo sapiens	34-37
25995008-0	2016	The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.	Benzo(a)pyrene	89-103	transformation related protein 53	Mus musculus	14-17
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	116-130	tumor protein p53	Homo sapiens	34-37
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	116-130	tumor protein p53	Homo sapiens	175-178
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	186-211
26919089-2	2016	In this study human recombinant CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed in Supersomes  together with their reductases, NADPH:CYP oxidoreductase, epoxide hydrolase and cytochrome b5 , to investigate BaP metabolism.	Benzo(a)pyrene	242-245	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-44
26919089-4	2016	Among these, BaP-7,8-dihydrodiol and BaP-9-ol, which are intermediates in BaP-derived DNA adduct formation, were mainly formed by CYP1A1 and 1B1, and to a lesser extent by CYP2C19 and 3A4.	Benzo(a)pyrene	13-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	130-144
26919089-4	2016	Among these, BaP-7,8-dihydrodiol and BaP-9-ol, which are intermediates in BaP-derived DNA adduct formation, were mainly formed by CYP1A1 and 1B1, and to a lesser extent by CYP2C19 and 3A4.	Benzo(a)pyrene	13-16	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	172-179
26919089-5	2016	BaP-3-ol, a metabolite that is a "detoxified" product of BaP, was formed by most human CYPs tested, although CYP1A1 and 1B1 produced it the most efficiently.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	109-123
26919089-7	2016	Our results indicate that hepatic CYP1A1 and CYP2C19 are most important in the activation of BaP to BaP-7,8-dihydrodiol, whereas CYP2C19, 3A4, and 1A1 are the major enzymes contributing to the formation of BaP-9-ol.	Benzo(a)pyrene	93-96	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40
26919089-7	2016	Our results indicate that hepatic CYP1A1 and CYP2C19 are most important in the activation of BaP to BaP-7,8-dihydrodiol, whereas CYP2C19, 3A4, and 1A1 are the major enzymes contributing to the formation of BaP-9-ol.	Benzo(a)pyrene	93-96	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	45-52
26963242-0	2016	Benzo(a)pyrene induces interleukin (IL)-6 production and reduces lipid synthesis in human SZ95 sebocytes via the aryl hydrocarbon receptor signaling pathway.	Benzo(a)pyrene	0-14	interleukin 6	Homo sapiens	23-41
26963242-0	2016	Benzo(a)pyrene induces interleukin (IL)-6 production and reduces lipid synthesis in human SZ95 sebocytes via the aryl hydrocarbon receptor signaling pathway.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	113-138
26963242-1	2016	In this study, we determined the effects of benzo(a)pyrene (BaP) on the expression of aryl hydrocarbon receptor (AhR) and cytochrome P450 1A1 (CYP1A1), and assessed the action of BaP on inflammatory cytokine expression and lipid synthesis in SZ95 sebocytes in vitro.	Benzo(a)pyrene	44-58	prohibitin 2	Homo sapiens	60-63
26963242-1	2016	In this study, we determined the effects of benzo(a)pyrene (BaP) on the expression of aryl hydrocarbon receptor (AhR) and cytochrome P450 1A1 (CYP1A1), and assessed the action of BaP on inflammatory cytokine expression and lipid synthesis in SZ95 sebocytes in vitro.	Benzo(a)pyrene	44-58	aryl hydrocarbon receptor	Homo sapiens	86-111
26963242-1	2016	In this study, we determined the effects of benzo(a)pyrene (BaP) on the expression of aryl hydrocarbon receptor (AhR) and cytochrome P450 1A1 (CYP1A1), and assessed the action of BaP on inflammatory cytokine expression and lipid synthesis in SZ95 sebocytes in vitro.	Benzo(a)pyrene	44-58	aryl hydrocarbon receptor	Homo sapiens	113-116
26963242-1	2016	In this study, we determined the effects of benzo(a)pyrene (BaP) on the expression of aryl hydrocarbon receptor (AhR) and cytochrome P450 1A1 (CYP1A1), and assessed the action of BaP on inflammatory cytokine expression and lipid synthesis in SZ95 sebocytes in vitro.	Benzo(a)pyrene	44-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
26657896-6	2016	Besides, we observed that BaP remodeled the protein content of membrane microdomains via increased expression of ZO-1, caveolin-1 and P2X7 cell degenerescence receptor.	Benzo(a)pyrene	26-29	tight junction protein 1	Homo sapiens	113-117
26657896-6	2016	Besides, we observed that BaP remodeled the protein content of membrane microdomains via increased expression of ZO-1, caveolin-1 and P2X7 cell degenerescence receptor.	Benzo(a)pyrene	26-29	caveolin 1	Homo sapiens	119-129
27003318-0	2016	Poly(ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Benzo(a)pyrene Induced Cell Transformation.	Benzo(a)pyrene	60-74	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
27003318-0	2016	Poly(ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Benzo(a)pyrene Induced Cell Transformation.	Benzo(a)pyrene	60-74	poly(ADP-ribose) glycohydrolase	Homo sapiens	33-37
27003318-1	2016	Benzo(a)pyrene (BaP) is a ubiquitously distributed environmental pollutant and known carcinogen, which can induce malignant transformation in rodent and human cells.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	132-135	tumor protein p53	Homo sapiens	175-178
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	132-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	186-211
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	242-245	tumor protein p53	Homo sapiens	34-37
25995008-2	2016	Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro.	Benzo(a)pyrene	242-245	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	186-211
25995008-4	2016	BaP-DNA adduct levels, as measured by (32)P-postlabelling analysis, were significantly higher in liver and kidney of Trp53(-/-) mice than of Trp53(+/+) mice.	Benzo(a)pyrene	0-3	transformation related protein 53	Mus musculus	117-122
25995008-4	2016	BaP-DNA adduct levels, as measured by (32)P-postlabelling analysis, were significantly higher in liver and kidney of Trp53(-/-) mice than of Trp53(+/+) mice.	Benzo(a)pyrene	0-3	transformation related protein 53	Mus musculus	141-146
25995008-5	2016	Complementarily, significantly higher amounts of BaP metabolites were also formed ex vivo in hepatic microsomes from BaP-pretreated Trp53(-/-) mice.	Benzo(a)pyrene	49-52	transformation related protein 53	Mus musculus	132-137
25995008-5	2016	Complementarily, significantly higher amounts of BaP metabolites were also formed ex vivo in hepatic microsomes from BaP-pretreated Trp53(-/-) mice.	Benzo(a)pyrene	117-120	transformation related protein 53	Mus musculus	132-137
25995008-7	2016	Higher BaP-DNA adduct levels in the livers of Trp53(-/-) mice correlated with higher CYP1A protein levels and increased CYP1A enzyme activity in these animals.	Benzo(a)pyrene	7-10	transformation related protein 53	Mus musculus	46-51
25995008-8	2016	Our study demonstrates a role for p53 in the metabolism of BaP in vivo, confirming previous in vitro results on a novel role for p53 in CYP1A1-mediated BaP metabolism.	Benzo(a)pyrene	59-62	transformation related protein 53	Mus musculus	34-37
25995008-8	2016	Our study demonstrates a role for p53 in the metabolism of BaP in vivo, confirming previous in vitro results on a novel role for p53 in CYP1A1-mediated BaP metabolism.	Benzo(a)pyrene	59-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	136-142
25995008-8	2016	Our study demonstrates a role for p53 in the metabolism of BaP in vivo, confirming previous in vitro results on a novel role for p53 in CYP1A1-mediated BaP metabolism.	Benzo(a)pyrene	152-155	transformation related protein 53	Mus musculus	129-132
25995008-8	2016	Our study demonstrates a role for p53 in the metabolism of BaP in vivo, confirming previous in vitro results on a novel role for p53 in CYP1A1-mediated BaP metabolism.	Benzo(a)pyrene	152-155	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	136-142
30090398-6	2016	Interestingly, treatment with benzo[a]pyrene and naphthalene significantly up regulated the phosphorylation of the p65 subunit of NF-kappaB and increased the secretion of TNF-alpha and CRP compared to control.	Benzo(a)pyrene	30-44	RELA proto-oncogene, NF-kB subunit	Homo sapiens	115-139
30090398-6	2016	Interestingly, treatment with benzo[a]pyrene and naphthalene significantly up regulated the phosphorylation of the p65 subunit of NF-kappaB and increased the secretion of TNF-alpha and CRP compared to control.	Benzo(a)pyrene	30-44	tumor necrosis factor	Homo sapiens	171-180
30090398-6	2016	Interestingly, treatment with benzo[a]pyrene and naphthalene significantly up regulated the phosphorylation of the p65 subunit of NF-kappaB and increased the secretion of TNF-alpha and CRP compared to control.	Benzo(a)pyrene	30-44	C-reactive protein	Homo sapiens	185-188
26709117-0	2016	Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.	Benzo(a)pyrene	101-115	B cell leukemia/lymphoma 2	Mus musculus	15-20
26709117-0	2016	Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.	Benzo(a)pyrene	101-115	BCL2-associated X protein	Mus musculus	22-25
26709117-0	2016	Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.	Benzo(a)pyrene	101-115	caspase 3	Mus musculus	27-36
26709117-0	2016	Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc expression in acute and subchronic exposure to benzo(a)pyrene in cervix.	Benzo(a)pyrene	101-115	antigen identified by monoclonal antibody Ki 67	Mus musculus	38-43
26709117-3	2016	BaP induced DNA damage and over expression in p53 cervical tissue of mice as demonstrated in our previous study.	Benzo(a)pyrene	0-3	transformation related protein 53, pseudogene	Mus musculus	46-49
26709117-4	2016	Here we present the findings of exposure to BaP on the expression of Bcl-2, C-myc, Ki-67, Caspase-3 and Bax genes in mouse cervix.	Benzo(a)pyrene	44-47	B cell leukemia/lymphoma 2	Mus musculus	69-74
26709117-4	2016	Here we present the findings of exposure to BaP on the expression of Bcl-2, C-myc, Ki-67, Caspase-3 and Bax genes in mouse cervix.	Benzo(a)pyrene	44-47	antigen identified by monoclonal antibody Ki 67	Mus musculus	83-88
26709117-4	2016	Here we present the findings of exposure to BaP on the expression of Bcl-2, C-myc, Ki-67, Caspase-3 and Bax genes in mouse cervix.	Benzo(a)pyrene	44-47	caspase 3	Mus musculus	90-99
26709117-4	2016	Here we present the findings of exposure to BaP on the expression of Bcl-2, C-myc, Ki-67, Caspase-3 and Bax genes in mouse cervix.	Benzo(a)pyrene	44-47	BCL2-associated X protein	Mus musculus	104-107
26709117-5	2016	Acute intraperitoneal administration of BaP (12.5, 25, 50, 100mg/kg body weight) to ICR female mice induced a significant increase in Bcl-2, C-myc, Ki-67 mRNA and protein level till 72h except in Bcl-2 at 24h with 12.5, 25, 50mg/kg as well as at 48h with 12.5mg/kg body weight post treatment.	Benzo(a)pyrene	40-43	B cell leukemia/lymphoma 2	Mus musculus	134-139
26709117-5	2016	Acute intraperitoneal administration of BaP (12.5, 25, 50, 100mg/kg body weight) to ICR female mice induced a significant increase in Bcl-2, C-myc, Ki-67 mRNA and protein level till 72h except in Bcl-2 at 24h with 12.5, 25, 50mg/kg as well as at 48h with 12.5mg/kg body weight post treatment.	Benzo(a)pyrene	40-43	antigen identified by monoclonal antibody Ki 67	Mus musculus	148-153
26709117-5	2016	Acute intraperitoneal administration of BaP (12.5, 25, 50, 100mg/kg body weight) to ICR female mice induced a significant increase in Bcl-2, C-myc, Ki-67 mRNA and protein level till 72h except in Bcl-2 at 24h with 12.5, 25, 50mg/kg as well as at 48h with 12.5mg/kg body weight post treatment.	Benzo(a)pyrene	40-43	B cell leukemia/lymphoma 2	Mus musculus	196-201
26709117-7	2016	In sub chronic intraperitoneal and oral gavage administration of BaP (2.5, 5, 10mg/kg body weight), similar significant increase was observed for all the examined genes as compared to the control and vehicle groups, however the expression of Bax decreased in a dose dependent manner.	Benzo(a)pyrene	65-68	BCL2-associated X protein	Mus musculus	242-245
27262192-0	2016	Interaction of Nucleotide Excision Repair Protein XPC-RAD23B with DNA Containing Benzo[a]pyrene-Derived Adduct and Apurinic/Apyrimidinic Site within a Cluster.	Benzo(a)pyrene	81-95	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	50-53
27262192-0	2016	Interaction of Nucleotide Excision Repair Protein XPC-RAD23B with DNA Containing Benzo[a]pyrene-Derived Adduct and Apurinic/Apyrimidinic Site within a Cluster.	Benzo(a)pyrene	81-95	RAD23 homolog B, nucleotide excision repair protein	Homo sapiens	54-60
27143372-4	2016	In rats treated by both BP, and DDT the hepatic content of miR-21, -221, -222 significantly demonstrated a 2-3-fold decrease.	Benzo(a)pyrene	24-26	microRNA 21	Rattus norvegicus	59-65
26225487-0	2016	Longitudinal Effect of CPAP on BP in Resistant and Nonresistant Hypertension in a Large Clinic-Based Cohort.	Benzo(a)pyrene	31-33	centromere protein J	Homo sapiens	23-27
26225487-2	2016	We hypothesize that CPAP use in SDB reduces BP significantly in RHTN and non-RHTN in a large clinic-based cohort.	Benzo(a)pyrene	44-46	centromere protein J	Homo sapiens	20-24
26225487-9	2016	CONCLUSIONS: In this clinic-based effectiveness study involving patients closely followed for BP control, a significant reduction of BP measures (strongest for SBP) was observed in response to CPAP which was similar in RHTN and non-RHTN groups thus informing expected clinical CPAP treatment response.	Benzo(a)pyrene	94-96	centromere protein J	Homo sapiens	193-197
26225487-9	2016	CONCLUSIONS: In this clinic-based effectiveness study involving patients closely followed for BP control, a significant reduction of BP measures (strongest for SBP) was observed in response to CPAP which was similar in RHTN and non-RHTN groups thus informing expected clinical CPAP treatment response.	Benzo(a)pyrene	133-135	centromere protein J	Homo sapiens	193-197
26225487-9	2016	CONCLUSIONS: In this clinic-based effectiveness study involving patients closely followed for BP control, a significant reduction of BP measures (strongest for SBP) was observed in response to CPAP which was similar in RHTN and non-RHTN groups thus informing expected clinical CPAP treatment response.	Benzo(a)pyrene	133-135	centromere protein J	Homo sapiens	277-281
26998077-1	2016	Benzo(a)pyrene (BaP) stimulates lung cancer cells, promoting monocyte-derived dendritic cells to secrete soluble factors, including heparin binding-epidermal growth factor and C-X-C motif chemokine 5.	Benzo(a)pyrene	0-14	C-X-C motif chemokine ligand 5	Homo sapiens	176-199
26914776-4	2016	Treatment with mineralocorticoid receptor antagonists or adrenalectomy gives similar reductions in BP.	Benzo(a)pyrene	99-101	nuclear receptor subfamily 3 group C member 2	Homo sapiens	15-41
26998077-1	2016	Benzo(a)pyrene (BaP) stimulates lung cancer cells, promoting monocyte-derived dendritic cells to secrete soluble factors, including heparin binding-epidermal growth factor and C-X-C motif chemokine 5.	Benzo(a)pyrene	16-19	C-X-C motif chemokine ligand 5	Homo sapiens	176-199
26998077-7	2016	The results of the present study suggest that prolonged exposure to BaP exacerbates lung cancer, particularly in female lung cancer patients with the BRAF mutation, but that laricitrin may ameliorate this effect.	Benzo(a)pyrene	68-71	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	150-154
26915282-3	2016	This study investigates BP and BZ biodegradation and subsequent carbon flow through the microbial community in PCB-contaminated soil.	Benzo(a)pyrene	24-26	pyruvate carboxylase	Homo sapiens	111-114
27030648-15	2016	Compared with those of patients in group CT, creatinine at PIH 48 and urea nitrogen at PIH 24, 48, 72 were obviously lower in group BP (with t values from -4.23 to -2.44, P&lt;0.05 or P&lt;0.01).	Benzo(a)pyrene	132-134	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	59-62
27030648-15	2016	Compared with those of patients in group CT, creatinine at PIH 48 and urea nitrogen at PIH 24, 48, 72 were obviously lower in group BP (with t values from -4.23 to -2.44, P&lt;0.05 or P&lt;0.01).	Benzo(a)pyrene	132-134	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	87-90
26901155-0	2016	Chronic Administration of Benzo(a)pyrene Induces Memory Impairment and Anxiety-Like Behavior and Increases of NR2B DNA Methylation.	Benzo(a)pyrene	26-40	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	110-114
26901155-9	2016	CONCLUSIONS: Chronic BaP exposure induces an increase in DNA methylation in the NR2B gene promoter and down-regulates NR2B expression, which may contribute to its neurotoxic effects on behavioral performance.	Benzo(a)pyrene	21-24	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	80-84
26901155-9	2016	CONCLUSIONS: Chronic BaP exposure induces an increase in DNA methylation in the NR2B gene promoter and down-regulates NR2B expression, which may contribute to its neurotoxic effects on behavioral performance.	Benzo(a)pyrene	21-24	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	118-122
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	annexin A3	Rattus norvegicus	109-113
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	beclin 1	Rattus norvegicus	115-123
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	128-131
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	caspase 3	Rattus norvegicus	167-176
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	caspase 8	Rattus norvegicus	178-187
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	caspase 9	Rattus norvegicus	189-198
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	BCL2, apoptosis regulator	Rattus norvegicus	209-214
27158406-9	2016	Furthermore, BP stimulated autophagy and inhibited apoptosis via modulated the autophagy-associated proteins LC 3, Beclin-1 and p62, and apoptosis-modulating proteins caspase 3, caspase 8, caspase 9, PARP and BCL-2/Bax.	Benzo(a)pyrene	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	215-218
26748308-7	2016	In conclusion, serum NRP2, CLU and AKAP12 could be potential biomarkers of BaP-induced lung cancer.	Benzo(a)pyrene	75-78	neuropilin 2	Mus musculus	21-25
26335255-1	2016	The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation.	Benzo(a)pyrene	135-149	transformation related protein 53	Mus musculus	39-42
26335255-1	2016	The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation.	Benzo(a)pyrene	135-149	transformation related protein 53	Mus musculus	173-176
26335255-1	2016	The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation.	Benzo(a)pyrene	135-149	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	184-199
26335255-1	2016	The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation.	Benzo(a)pyrene	135-149	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	201-204
26748308-7	2016	In conclusion, serum NRP2, CLU and AKAP12 could be potential biomarkers of BaP-induced lung cancer.	Benzo(a)pyrene	75-78	clusterin	Mus musculus	27-30
26748308-7	2016	In conclusion, serum NRP2, CLU and AKAP12 could be potential biomarkers of BaP-induced lung cancer.	Benzo(a)pyrene	75-78	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	35-41
27430910-6	2016	In OGD-treated neurons, BP enhanced HIF-1[Formula: see text] accumulation with activation of PI3K/Akt, and induced S1P production by activating Sphk2 via the promotion of HIF-1[Formula: see text]-mediated Sphk2 transcription.	Benzo(a)pyrene	24-26	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	aryl hydrocarbon receptor	Homo sapiens	28-53
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	aryl hydrocarbon receptor	Homo sapiens	55-58
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	tumor protein p53	Homo sapiens	200-203
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	tumor protein p53	Homo sapiens	200-203
25398514-8	2016	CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription.	Benzo(a)pyrene	148-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166
26679980-0	2016	Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus.	Benzo(a)pyrene	23-37	B cell leukemia/lymphoma 2	Mus musculus	72-77
26679980-0	2016	Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus.	Benzo(a)pyrene	23-37	antigen identified by monoclonal antibody Ki 67	Mus musculus	79-84
26679980-0	2016	Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus.	Benzo(a)pyrene	23-37	transformation related protein 53, pseudogene	Mus musculus	96-99
26679980-0	2016	Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus.	Benzo(a)pyrene	23-37	BCL2-associated X protein	Mus musculus	101-104
26679980-0	2016	Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus.	Benzo(a)pyrene	23-37	caspase 3	Mus musculus	106-115
25816899-6	2016	Milk yield was lowest (P &lt; 0.01) for 50% BP diet than the other treatments.	Benzo(a)pyrene	44-46	Weaning weight-maternal milk	Bos taurus	0-4
25816899-10	2016	However, replacing BP for barley grain at 50% had adverse effects on DMI, milk yield and metabolic status, as indicated by key blood metabolite concentrations.	Benzo(a)pyrene	19-21	Weaning weight-maternal milk	Bos taurus	74-78
26706021-6	2016	We noted that BDNF protects against cytotoxic actions of alloxan, streptozotocin, and benzo(a)pyrene.	Benzo(a)pyrene	86-100	brain derived neurotrophic factor	Homo sapiens	14-18
26776515-3	2016	The autism-related IgCAM, MDGA1, is locally expressed in the BP cell membrane where it co-localizes and complexes with the gap junction protein Connexin43.	Benzo(a)pyrene	61-63	MAM domain containing glycosylphosphatidylinositol anchor 1	Homo sapiens	26-31
26776515-3	2016	The autism-related IgCAM, MDGA1, is locally expressed in the BP cell membrane where it co-localizes and complexes with the gap junction protein Connexin43.	Benzo(a)pyrene	61-63	gap junction protein alpha 1	Homo sapiens	144-154
26776515-5	2016	MDGA1 deletion results in reduced BP proliferation and size of the SVZ, with an aberrant population of BPs ectopically positioned in the cortical plate.	Benzo(a)pyrene	34-36	MAM domain containing glycosylphosphatidylinositol anchor 1	Homo sapiens	0-5
27430910-6	2016	In OGD-treated neurons, BP enhanced HIF-1[Formula: see text] accumulation with activation of PI3K/Akt, and induced S1P production by activating Sphk2 via the promotion of HIF-1[Formula: see text]-mediated Sphk2 transcription.	Benzo(a)pyrene	24-26	sphingosine kinase 2	Rattus norvegicus	144-149
27430910-6	2016	In OGD-treated neurons, BP enhanced HIF-1[Formula: see text] accumulation with activation of PI3K/Akt, and induced S1P production by activating Sphk2 via the promotion of HIF-1[Formula: see text]-mediated Sphk2 transcription.	Benzo(a)pyrene	24-26	sphingosine kinase 2	Rattus norvegicus	205-210
26186091-0	2016	Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.	Benzo(a)pyrene	70-84	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	6-11
26670775-2	2016	In the binary mixture, the biodegradation of less-degradable oxytetracycline (OTC) was restarted in the presence of more degradable benzo[a]pyrene (BaP) in the initial runs of the AMCBR, but enhanced biodegradation of the more recalcitrant OTC occurs in the later runs of the AMCBR due to enhanced biomass growth on dual substrates without the primary carbon source.	Benzo(a)pyrene	132-146	prohibitin 2	Homo sapiens	148-151
26655880-0	2016	Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFkappaB and PCNA expression.	Benzo(a)pyrene	62-76	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	124-130
26655880-0	2016	Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFkappaB and PCNA expression.	Benzo(a)pyrene	62-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-140
26655880-0	2016	Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFkappaB and PCNA expression.	Benzo(a)pyrene	62-76	proliferating cell nuclear antigen	Mus musculus	145-149
26731659-0	2016	Xeroderma pigmentosum, complementation group D expression in H1299 lung cancer cells following benzo[a]pyrene exposure as well as in head and neck cancer patients.	Benzo(a)pyrene	95-109	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-46
26731659-2	2016	Benzo[a]pyrene (BaP), the most carcinogenic polycyclic aromatic hydrocarbon (PAH), is classified as a group 1 carcinogen by International Agency for Research on Cancer.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
27924717-0	2016	Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells.	Benzo(a)pyrene	11-25	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-79
27924717-2	2016	The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities.	Benzo(a)pyrene	235-249	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	197-203
27924717-2	2016	The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities.	Benzo(a)pyrene	251-254	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	197-203
27924717-6	2016	Concentration-dependent elevation in CYP1A1 activities accompanied by increasing protein levels was found after treating cells with BaP and 1- or 2-NA.	Benzo(a)pyrene	132-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	37-43
27924717-9	2016	Our results suggest that RT-4 cells represent a reliable model cell line to study arylamine- and PAH-induced effects in vitro and that BaP-induced CYP1A1 activities are modulated by aromatic amines.	Benzo(a)pyrene	135-138	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	147-153
26530167-2	2016	Benzo(a)pyrene (B(a)P), a representative PAH compound is released into the environment from automobile exhausts, industrial emissions, and considerable intake of B(a)P is also expected in people who are smokers and barbecued red meat eaters.	Benzo(a)pyrene	0-14	phenylalanine hydroxylase	Homo sapiens	41-44
26552516-0	2016	Measurement of human CYP1A2 induction by inhalation exposure to benzo(a)pyrene based on in vivo isotope breath method.	Benzo(a)pyrene	64-78	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27
26552516-2	2016	To date, few studies have investigated in vivo CYP1A2 induction in humans and its relationship to polycylic aromatic hydrocarbons (PAHs) like benzo(a)pyrene (BaP).	Benzo(a)pyrene	142-156	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
26552516-2	2016	To date, few studies have investigated in vivo CYP1A2 induction in humans and its relationship to polycylic aromatic hydrocarbons (PAHs) like benzo(a)pyrene (BaP).	Benzo(a)pyrene	158-161	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53
26552516-8	2016	Hepatic CYP1A2 activity/induction level was not effected by inhaled BaP but was altered by ingestion of BaP.	Benzo(a)pyrene	104-107	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	8-14
26530167-2	2016	Benzo(a)pyrene (B(a)P), a representative PAH compound is released into the environment from automobile exhausts, industrial emissions, and considerable intake of B(a)P is also expected in people who are smokers and barbecued red meat eaters.	Benzo(a)pyrene	16-21	phenylalanine hydroxylase	Homo sapiens	41-44
26530167-2	2016	Benzo(a)pyrene (B(a)P), a representative PAH compound is released into the environment from automobile exhausts, industrial emissions, and considerable intake of B(a)P is also expected in people who are smokers and barbecued red meat eaters.	Benzo(a)pyrene	162-167	phenylalanine hydroxylase	Homo sapiens	41-44
27110038-0	2016	NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.	Benzo(a)pyrene	68-82	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	125-144
25224404-9	2015	In the presence of B(a)P, activation of AhR or antagonist effects were observed depending on the AA or its N-acetylated metabolite.	Benzo(a)pyrene	19-24	aryl hydrocarbon receptor	Homo sapiens	40-43
27110038-7	2016	In the presence of either of the reductase cofactors tested, NADPH or NADH, cytochrome b5 stimulated CYP1A1-mediated formation of both BaP-DNA adducts.	Benzo(a)pyrene	135-138	cytochrome b5 type A	Rattus norvegicus	76-89
27110038-7	2016	In the presence of either of the reductase cofactors tested, NADPH or NADH, cytochrome b5 stimulated CYP1A1-mediated formation of both BaP-DNA adducts.	Benzo(a)pyrene	135-138	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	101-107
27110038-8	2016	The results demonstrate that NADH can act as a sole electron donor for both the first and the second reduction of CYP1A1 during its reaction cycle catalyzing oxidation of BaP, and suggest that the NADH:cytochrome b5 reductase as the NADH-dependent reductase might substitute POR in this enzymatic system.	Benzo(a)pyrene	171-174	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	114-120
27110038-8	2016	The results demonstrate that NADH can act as a sole electron donor for both the first and the second reduction of CYP1A1 during its reaction cycle catalyzing oxidation of BaP, and suggest that the NADH:cytochrome b5 reductase as the NADH-dependent reductase might substitute POR in this enzymatic system.	Benzo(a)pyrene	171-174	cytochrome b5 type A	Rattus norvegicus	202-215
27110039-0	2016	Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine.	Benzo(a)pyrene	120-134	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	33-52
27110039-7	2016	Since CYP2S1 was shown to catalyze oxidation of compounds having polycyclic aromatic structures, the prepared enzyme has been tested to metabolize the compounds having this structural character; namely, the human carcinogen benzo[a]pyrene (BaP), its 7,8-dihydrodiol derivative, and an anticancer drug ellipticine.	Benzo(a)pyrene	240-243	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	6-12
27110039-10	2016	The results found in this study demonstrate that CYP2S1 in the presence of cumene hydroperoxide or hydrogen peroxide catalyzes oxidation of two of the test xenobiotics, a metabolite of BaP, BaP-7,8-dihydrodiol, and ellipticine.	Benzo(a)pyrene	185-188	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	49-55
27110040-0	2016	Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).	Benzo(a)pyrene	117-131	cytochrome b5 type A	Rattus norvegicus	33-46
27110040-2	2016	We investigated the influence of exposure to the anticancer drug ellipticine and to two environmental carcinogens, benzo[a]pyrene (BaP) and 1-phenylazo-2-naphthol (Sudan I), on the expression of cytochrome b5 in livers of rats, both at the mRNA and protein levels.	Benzo(a)pyrene	115-129	cytochrome b5 type A	Rattus norvegicus	195-208
27110040-2	2016	We investigated the influence of exposure to the anticancer drug ellipticine and to two environmental carcinogens, benzo[a]pyrene (BaP) and 1-phenylazo-2-naphthol (Sudan I), on the expression of cytochrome b5 in livers of rats, both at the mRNA and protein levels.	Benzo(a)pyrene	131-134	cytochrome b5 type A	Rattus norvegicus	195-208
26497318-6	2016	Furthermore, the potential interacting orientations of BP and 814 with BLyS were studied.	Benzo(a)pyrene	55-57	TNF superfamily member 13b	Homo sapiens	71-75
26482258-11	2015	Associations between BP and both renal end point and rate of eGFR decline were similar to those with the primary end point.	Benzo(a)pyrene	21-23	epidermal growth factor receptor	Homo sapiens	61-65
25204754-4	2015	Decreased endogenous H2 S levels have been found in hypertensive patients and animals, and CSE(-/-) mice develop hypertension with age, suggesting that a deficiency in H2 S contributes importantly to BP regulation.	Benzo(a)pyrene	200-202	cystathionine gamma-lyase	Homo sapiens	91-94
26456900-7	2015	A significant downregulation of ATF4 and/or osterix and a high biological variability of COL10, coupled with a significant deregulation of SOX9a/b in the F1-F3 suggest that ancestral BaP exposure most likely perturbed chordoblasts, chondroblast and osteoblast differentiation, resulting in defective notochord sheath repair and rendering the vertebral column more vulnerable to compression.	Benzo(a)pyrene	183-186	cyclic AMP-dependent transcription factor ATF-4	Oryzias latipes	32-36
26450431-4	2015	RESULTS: RDX decreased plasma and renal tissue noradrenaline (norepinephrine) levels and BP.	Benzo(a)pyrene	89-91	radixin	Rattus norvegicus	9-12
25855778-0	2015	Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.	Benzo(a)pyrene	50-52	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	17-31
26247513-2	2015	The transcription factor NRF2 is an important regulator of the cellular response to electrophilic toxicants like BaP and to oxidative stress.	Benzo(a)pyrene	113-116	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
25855778-7	2015	These findings suggest that direct actions of AT1A receptors in VSMCs are essential for regulation of renal blood flow by Ang II and highlight the capacity of Ang II-dependent vascular responses in the kidney to effect natriuresis and BP control.	Benzo(a)pyrene	235-237	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	159-165
25918036-9	2015	These findings indicate that FGF1 expression in the kidney is at least under partial genetic control and that renal expression of several FGF1 partner genes involved in the natriuretic peptide catabolism pathway, renin-angiotensin cascade, and sodium handling network may explain the association between FGF1 and BP.	Benzo(a)pyrene	313-315	fibroblast growth factor 1	Homo sapiens	138-142
25918036-9	2015	These findings indicate that FGF1 expression in the kidney is at least under partial genetic control and that renal expression of several FGF1 partner genes involved in the natriuretic peptide catabolism pathway, renin-angiotensin cascade, and sodium handling network may explain the association between FGF1 and BP.	Benzo(a)pyrene	313-315	fibroblast growth factor 1	Homo sapiens	138-142
26679793-6	2015	BaP down-regulated AhR protein levels; however, increased its translocation from the cytoplasm to nucleus and suppressed PPARgamma expression during adipogenesis.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Canis lupus familiaris	19-22
26679793-6	2015	BaP down-regulated AhR protein levels; however, increased its translocation from the cytoplasm to nucleus and suppressed PPARgamma expression during adipogenesis.	Benzo(a)pyrene	0-3	peroxisome proliferator activated receptor gamma	Canis lupus familiaris	121-130
26679793-7	2015	BaP increased the expression of AhR signaling pathway protein, cytochrome P450 (CYP1A1) in ADMSCs.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Canis lupus familiaris	32-35
26247513-3	2015	NRF2 regulates transcription of genes involved in the detoxification of reactive metabolites of BaP and reactive oxygen species.	Benzo(a)pyrene	96-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
26679793-7	2015	BaP increased the expression of AhR signaling pathway protein, cytochrome P450 (CYP1A1) in ADMSCs.	Benzo(a)pyrene	0-3	Cytochrome P450 1A1	Canis lupus familiaris	63-86
26247513-4	2015	We therefore hypothesized that Nrf2-/- mice have accelerated ovarian aging and increased sensitivity to the ovarian toxicity of BaP.	Benzo(a)pyrene	128-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35
26247513-5	2015	A single injection of BaP dose-dependently depleted ovarian follicles in Nrf2+/+ and Nrf2-/- mice, but the effects of BaP were not enhanced in the absence of Nrf2.	Benzo(a)pyrene	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
26247513-5	2015	A single injection of BaP dose-dependently depleted ovarian follicles in Nrf2+/+ and Nrf2-/- mice, but the effects of BaP were not enhanced in the absence of Nrf2.	Benzo(a)pyrene	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
26247513-5	2015	A single injection of BaP dose-dependently depleted ovarian follicles in Nrf2+/+ and Nrf2-/- mice, but the effects of BaP were not enhanced in the absence of Nrf2.	Benzo(a)pyrene	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
26350169-1	2015	High endogenous levels of aryl hydrocarbon receptor (AhR) contribute to hypoxia signaling pathway inhibition following exposure to the potent AhR ligand benzo[a]pyrene (B[a]P) and could alter cellular homeostasis and disease condition.	Benzo(a)pyrene	153-167	aryl hydrocarbon receptor	Homo sapiens	26-51
26350169-1	2015	High endogenous levels of aryl hydrocarbon receptor (AhR) contribute to hypoxia signaling pathway inhibition following exposure to the potent AhR ligand benzo[a]pyrene (B[a]P) and could alter cellular homeostasis and disease condition.	Benzo(a)pyrene	153-167	aryl hydrocarbon receptor	Homo sapiens	53-56
26350169-1	2015	High endogenous levels of aryl hydrocarbon receptor (AhR) contribute to hypoxia signaling pathway inhibition following exposure to the potent AhR ligand benzo[a]pyrene (B[a]P) and could alter cellular homeostasis and disease condition.	Benzo(a)pyrene	153-167	aryl hydrocarbon receptor	Homo sapiens	142-145
30090357-6	2016	Exposure to BaP or alcohol significantly decreased daily sperm production, sperm density, percentages of motile, viable, HOS-tail swelled sperm, testicular 3beta- and 17beta-hydroxysteroid dehydrogenase activity levels, mRNA levels of steroidogenic acute regulatory protein, and serum testosterone levels.	Benzo(a)pyrene	12-15	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	145-202
26091794-8	2015	Increased expressions of TGIF protein and mRNA were observed in 16HBE cells induced by BaP treatment as compared to those in solvent control group.	Benzo(a)pyrene	87-90	TGFB induced factor homeobox 1	Homo sapiens	25-29
26091794-9	2015	We observed significantly higher levels of TGIF mRNA and protein in 16HBE-BaP cells than that in 16HBE-control cells.	Benzo(a)pyrene	74-77	TGFB induced factor homeobox 1	Homo sapiens	43-47
26091794-10	2015	We observed significantly higher levels of TGIF mRNA and protein in mice lung tissues treated with BaP than that in control group.	Benzo(a)pyrene	99-102	TGFB-induced factor homeobox 1	Mus musculus	43-47
30090347-1	2016	Genotoxic carcinogens are present in the human diet, and two important examples are benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).	Benzo(a)pyrene	84-98	prohibitin 2	Homo sapiens	100-103
26565418-5	2015	The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer.	Benzo(a)pyrene	19-33	chemokine (C-X-C motif) ligand 13	Mus musculus	48-54
26565418-5	2015	The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer.	Benzo(a)pyrene	35-38	chemokine (C-X-C motif) ligand 13	Mus musculus	48-54
26565418-6	2015	Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13"s critical role in PAH-induced lung carcinogenesis.	Benzo(a)pyrene	70-73	chemokine (C-X-C motif) ligand 13	Mus musculus	14-20
26565418-6	2015	Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13"s critical role in PAH-induced lung carcinogenesis.	Benzo(a)pyrene	70-73	chemokine (C-X-C motif) receptor 5	Mus musculus	38-43
26303333-0	2015	Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.	Benzo(a)pyrene	88-102	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	35-40
26303333-0	2015	Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.	Benzo(a)pyrene	88-102	solute carrier family 13 member 5	Homo sapiens	42-49
26303333-7	2015	In accordance with such a hypothesis, the AhR activator benzo[a]pyrene induced the mINDY expression in primary cultures of rat hepatocytes in an AhR-dependent manner.	Benzo(a)pyrene	56-70	aryl hydrocarbon receptor	Rattus norvegicus	42-45
26303333-7	2015	In accordance with such a hypothesis, the AhR activator benzo[a]pyrene induced the mINDY expression in primary cultures of rat hepatocytes in an AhR-dependent manner.	Benzo(a)pyrene	56-70	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	83-88
26303333-7	2015	In accordance with such a hypothesis, the AhR activator benzo[a]pyrene induced the mINDY expression in primary cultures of rat hepatocytes in an AhR-dependent manner.	Benzo(a)pyrene	56-70	aryl hydrocarbon receptor	Rattus norvegicus	145-148
26303333-10	2015	Elimination or mutation of this site largely abolished the activation of the mINDY promoter by benzo[a]pyrene.	Benzo(a)pyrene	95-109	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	77-82
26231923-10	2015	The CYP1Cs and CYP1D1 co-expressed with epoxide hydrolase oxidized BaP with different rates and product profiles, and all three produced BaP-7,8,9,10-tetrol.	Benzo(a)pyrene	67-70	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	15-21
26643788-7	2015	Moreover, curcumin diet reduced benzo[a]pyrene-induced activation of NF-kappaB and MAPK signaling and Cox-2 transcription in lung tissues of mice.	Benzo(a)pyrene	32-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
26643788-7	2015	Moreover, curcumin diet reduced benzo[a]pyrene-induced activation of NF-kappaB and MAPK signaling and Cox-2 transcription in lung tissues of mice.	Benzo(a)pyrene	32-46	cytochrome c oxidase II, mitochondrial	Mus musculus	102-107
26438356-7	2015	We observed that BaP (7, 12 and 18 microg/L) induced an increase of DNA strand break levels as soon as 6 h of exposure and that the two highest concentrations of BaP induced a low level of hOGG1-sensitive sites.	Benzo(a)pyrene	162-165	8-oxoguanine DNA glycosylase	Homo sapiens	189-194
26522487-8	2015	Five-year weight changes associate with BP alterations, even after adjustment for changes in lifestyle risk factors and serum insulin.	Benzo(a)pyrene	40-42	insulin	Homo sapiens	126-133
25280508-12	2015	Isolated BaP treatment increased GST activity after 10 days.	Benzo(a)pyrene	9-12	glutathione S-transferase	Oreochromis niloticus	33-36
25280508-13	2015	However, this response was not observed in the mixture treatment, suggesting that E2 suppressed the GST induction modulated by BaP.	Benzo(a)pyrene	127-130	glutathione S-transferase	Oreochromis niloticus	100-103
26438356-11	2015	As the level of hOGG1 sensitive sites was increased in Cd and BaP exposed mussels, it seems that these chemicals induce 8-oxo-dG.	Benzo(a)pyrene	62-65	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
26595742-0	2015	The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.	Benzo(a)pyrene	93-107	ATR serine/threonine kinase	Homo sapiens	30-33
26595742-0	2015	The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.	Benzo(a)pyrene	93-107	ATM serine/threonine kinase	Homo sapiens	25-28
26595742-0	2015	The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.	Benzo(a)pyrene	93-107	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	35-41
26400171-0	2015	Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability.	Benzo(a)pyrene	94-108	tumor protein p53	Homo sapiens	40-44
26400171-3	2015	Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen that forms guanine adducts at TP53 CpG mutation hotspot sites including codons 157, 158, 245, 248 and 273.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	104-108
26271895-0	2015	Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.	Benzo(a)pyrene	78-92	Wnt inhibitory factor 1	Mus musculus	0-4
28959548-9	2016	Furthermore, treatments with the mucoadhesive formulation containing BP/CL up modulated Ki-67 and Bcl-2 expression while reduced pro-apoptotic regulator Bax.	Benzo(a)pyrene	69-71	B cell leukemia/lymphoma 2	Mus musculus	98-103
28959548-9	2016	Furthermore, treatments with the mucoadhesive formulation containing BP/CL up modulated Ki-67 and Bcl-2 expression while reduced pro-apoptotic regulator Bax.	Benzo(a)pyrene	69-71	BCL2-associated X protein	Mus musculus	153-156
26466350-3	2015	Inhibition of dopamine D2-receptors with sulpiride (SULP) significantly repressed the constitutive and benzo[a]pyrene (B[a]P)-induced CYP1A1, CYP1A2 and CYP1B expression in the rat liver.	Benzo(a)pyrene	103-117	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	134-140
26466350-3	2015	Inhibition of dopamine D2-receptors with sulpiride (SULP) significantly repressed the constitutive and benzo[a]pyrene (B[a]P)-induced CYP1A1, CYP1A2 and CYP1B expression in the rat liver.	Benzo(a)pyrene	103-117	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-148
26466350-3	2015	Inhibition of dopamine D2-receptors with sulpiride (SULP) significantly repressed the constitutive and benzo[a]pyrene (B[a]P)-induced CYP1A1, CYP1A2 and CYP1B expression in the rat liver.	Benzo(a)pyrene	119-124	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	134-140
26466350-3	2015	Inhibition of dopamine D2-receptors with sulpiride (SULP) significantly repressed the constitutive and benzo[a]pyrene (B[a]P)-induced CYP1A1, CYP1A2 and CYP1B expression in the rat liver.	Benzo(a)pyrene	119-124	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-148
26271895-0	2015	Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.	Benzo(a)pyrene	78-92	interferon induced transmembrane protein 3	Mus musculus	9-15
26271895-7	2015	Furthermore, comparative gene expression analysis combined with Ingenuity Pathway Analysis  identified 2 genes associated with Wnt/beta-catenin signaling pathway that were preferentially up-regulated (&gt;=2-fold vs vehicle group) when BP and DSS were treated in combination in the distal part (site of predilection for tumor induction) of the colonic mucosae, especially in colonic tumors: WNT inhibitory factor 1 (Wif1; 14.6-fold increase) and interferon induced membrane protein 3 (Ifitm3; 5.7-fold increase).	Benzo(a)pyrene	236-238	catenin (cadherin associated protein), beta 1	Mus musculus	131-143
26271895-7	2015	Furthermore, comparative gene expression analysis combined with Ingenuity Pathway Analysis  identified 2 genes associated with Wnt/beta-catenin signaling pathway that were preferentially up-regulated (&gt;=2-fold vs vehicle group) when BP and DSS were treated in combination in the distal part (site of predilection for tumor induction) of the colonic mucosae, especially in colonic tumors: WNT inhibitory factor 1 (Wif1; 14.6-fold increase) and interferon induced membrane protein 3 (Ifitm3; 5.7-fold increase).	Benzo(a)pyrene	236-238	Wnt inhibitory factor 1	Mus musculus	391-414
26271895-7	2015	Furthermore, comparative gene expression analysis combined with Ingenuity Pathway Analysis  identified 2 genes associated with Wnt/beta-catenin signaling pathway that were preferentially up-regulated (&gt;=2-fold vs vehicle group) when BP and DSS were treated in combination in the distal part (site of predilection for tumor induction) of the colonic mucosae, especially in colonic tumors: WNT inhibitory factor 1 (Wif1; 14.6-fold increase) and interferon induced membrane protein 3 (Ifitm3; 5.7-fold increase).	Benzo(a)pyrene	236-238	Wnt inhibitory factor 1	Mus musculus	416-420
26271895-7	2015	Furthermore, comparative gene expression analysis combined with Ingenuity Pathway Analysis  identified 2 genes associated with Wnt/beta-catenin signaling pathway that were preferentially up-regulated (&gt;=2-fold vs vehicle group) when BP and DSS were treated in combination in the distal part (site of predilection for tumor induction) of the colonic mucosae, especially in colonic tumors: WNT inhibitory factor 1 (Wif1; 14.6-fold increase) and interferon induced membrane protein 3 (Ifitm3; 5.7-fold increase).	Benzo(a)pyrene	236-238	interferon induced transmembrane protein 3	Mus musculus	485-491
26116984-6	2015	The calculated coupling efficiency of 0.067+-0.018 ATP/ISWI/bp is seemingly quite low in comparison to similar DNA translocases and we present potential models to account for this.	Benzo(a)pyrene	60-62	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	Homo sapiens	55-59
26215100-4	2015	A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1.	Benzo(a)pyrene	136-150	aryl-hydrocarbon receptor	Mus musculus	38-41
26215100-4	2015	A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1.	Benzo(a)pyrene	136-150	aryl-hydrocarbon receptor	Mus musculus	91-94
26215100-4	2015	A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1.	Benzo(a)pyrene	136-150	aryl-hydrocarbon receptor	Mus musculus	91-94
26215100-4	2015	A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1.	Benzo(a)pyrene	136-150	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	186-192
26215100-4	2015	A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1.	Benzo(a)pyrene	136-150	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	197-203
26149760-0	2015	Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.	Benzo(a)pyrene	54-68	nuclear receptor subfamily 2 group E member 3	Homo sapiens	16-21
25994262-5	2015	Based on the toxicological equivalent factor (TEF) approach, total benzo[a]pyrene equivalent values in the HUA and NDA were 1.12 and 2.02 ng m(-3), respectively, exceeding the standard threshold values (1.0 ng m(-3)) of China and WHO.	Benzo(a)pyrene	67-81	TEF transcription factor, PAR bZIP family member	Homo sapiens	13-44
25994262-5	2015	Based on the toxicological equivalent factor (TEF) approach, total benzo[a]pyrene equivalent values in the HUA and NDA were 1.12 and 2.02 ng m(-3), respectively, exceeding the standard threshold values (1.0 ng m(-3)) of China and WHO.	Benzo(a)pyrene	67-81	TEF transcription factor, PAR bZIP family member	Homo sapiens	46-49
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	tumor protein p53	Homo sapiens	107-110
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 25	Homo sapiens	129-135
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 15a	Homo sapiens	137-144
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	glycerophosphodiester phosphodiesterase 1	Homo sapiens	146-152
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 9-2	Homo sapiens	154-160
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 141	Homo sapiens	172-179
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 200a	Homo sapiens	185-193
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 25	Homo sapiens	272-278
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	50-64	microRNA 9-2	Homo sapiens	283-289
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	tumor protein p53	Homo sapiens	107-110
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 25	Homo sapiens	129-135
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 15a	Homo sapiens	137-144
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	glycerophosphodiester phosphodiesterase 1	Homo sapiens	146-152
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 9-2	Homo sapiens	154-160
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 141	Homo sapiens	172-179
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 200a	Homo sapiens	185-193
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 25	Homo sapiens	272-278
24798859-5	2015	Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells.	Benzo(a)pyrene	66-69	microRNA 9-2	Homo sapiens	283-289
24798859-6	2015	The miR-25 promoter was activated by both BaP and TCDD, and this response was mediated by the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	42-45	microRNA 25	Homo sapiens	4-10
24798859-6	2015	The miR-25 promoter was activated by both BaP and TCDD, and this response was mediated by the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	42-45	aryl hydrocarbon receptor	Homo sapiens	94-119
24798859-6	2015	The miR-25 promoter was activated by both BaP and TCDD, and this response was mediated by the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	42-45	aryl hydrocarbon receptor	Homo sapiens	121-124
26149760-2	2015	Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-mediated cell injury.	Benzo(a)pyrene	43-57	nuclear receptor subfamily 2 group E member 3	Homo sapiens	34-39
26149760-2	2015	Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-mediated cell injury.	Benzo(a)pyrene	43-57	prohibitin 2	Homo sapiens	59-62
26148434-0	2015	Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene.	Benzo(a)pyrene	100-114	pyruvate carboxylase	Rattus norvegicus	23-26
25616378-1	2015	Benzo[a]pyrene-7,8-dione (BPQ) is formed by the activation of benzo[a]pyrene(B[a]P), which is an environmental toxic substance that is easily exposed in daily life, due to P450/epoxide hydrolase, and is a substance that induces DNA deformation by forming adducts with DNA.	Benzo(a)pyrene	62-76	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	172-176
25879807-8	2015	CPAP treatment significantly reduces BP in such patients and could play a clinical role in the management of BP in these patients.	Benzo(a)pyrene	37-39	centromere protein J	Homo sapiens	0-4
25879807-8	2015	CPAP treatment significantly reduces BP in such patients and could play a clinical role in the management of BP in these patients.	Benzo(a)pyrene	109-111	centromere protein J	Homo sapiens	0-4
25817024-8	2015	Stronger correlations (Pearson"s r as great as 0.881) were observed between concentrations of BDE congeners having the same number and pattern of bromine substitution on their phenyl rings in blood plasma and their corresponding BP-conjugates in urine.	Benzo(a)pyrene	229-231	homeobox D13	Homo sapiens	94-97
26561251-3	2015	Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzo{a}pyrene and halogenated dioxins.	Benzo(a)pyrene	156-170	aryl hydrocarbon receptor	Homo sapiens	0-25
26561251-3	2015	Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzo{a}pyrene and halogenated dioxins.	Benzo(a)pyrene	156-170	aryl hydrocarbon receptor	Homo sapiens	27-30
25817024-2	2015	In order to study the correlation between levels of PBDEs in human blood plasma and those of the corresponding BP-conjugates in human urine, concentrations of 17 BDE congeners, 22 OH-BDE and 13 MeO-BDE metabolites, and 3 BPs in plasma collected from 100 voluntary donors in Hong Kong were measured by gas chromatograph tandem mass spectrometry (GC-MS).	Benzo(a)pyrene	111-113	homeobox D13	Homo sapiens	53-56
26164786-16	2015	IMPLICATIONS: Treatment of L10/V80 or L10/V160 combination therapy resulted in significantly greater BP lowering compared with L10 monotherapy.	Benzo(a)pyrene	101-103	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	27-34
26164786-16	2015	IMPLICATIONS: Treatment of L10/V80 or L10/V160 combination therapy resulted in significantly greater BP lowering compared with L10 monotherapy.	Benzo(a)pyrene	101-103	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	38-46
26164786-17	2015	Moreover, the L20/V160 high dose combination had additional BP lowering effect compared with nonresponders with the L10/V160 combination.	Benzo(a)pyrene	60-62	immunoglobulin kappa variable 3D-11	Homo sapiens	14-22
25911668-0	2015	Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.	Benzo(a)pyrene	121-135	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	34-40
25911668-5	2015	Pulmonary Cyp1a1 enzyme activity was decreased in LPS/BaP-treated mice relative to BaP-treated mice suggesting that pulmonary inflammation impacted on BaP-induced Cyp1a1 activity in the lung.	Benzo(a)pyrene	54-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	10-16
25911668-5	2015	Pulmonary Cyp1a1 enzyme activity was decreased in LPS/BaP-treated mice relative to BaP-treated mice suggesting that pulmonary inflammation impacted on BaP-induced Cyp1a1 activity in the lung.	Benzo(a)pyrene	54-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	163-169
25911668-6	2015	Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung.	Benzo(a)pyrene	59-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	24-30
25911668-6	2015	Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung.	Benzo(a)pyrene	144-147	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	24-30
25911668-6	2015	Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung.	Benzo(a)pyrene	144-147	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-127
25911668-6	2015	Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung.	Benzo(a)pyrene	144-147	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	24-30
25911668-6	2015	Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung.	Benzo(a)pyrene	144-147	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-127
25911668-7	2015	Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only.	Benzo(a)pyrene	13-16	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	35-41
25911668-7	2015	Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only.	Benzo(a)pyrene	62-65	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	35-41
25911668-7	2015	Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only.	Benzo(a)pyrene	62-65	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	35-41
25911668-7	2015	Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only.	Benzo(a)pyrene	62-65	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	35-41
25911668-10	2015	Cyp1a1 appears to be involved in both BaP bioactivation and detoxification although the contribution of other enzymes to BaP-DNA adduct formation in lung and liver under inflammatory conditions remains to be explored.	Benzo(a)pyrene	38-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-6
26197327-10	2015	Moreover, an association was found between GSTM1 null and alterations related to BP, but we did not observe any effects of other polymorphisms.	Benzo(a)pyrene	81-83	glutathione S-transferase mu 1	Homo sapiens	43-48
25467232-14	2015	The BP-related impaired BMP-2-Msx-1-Dlx-5 axis might explain the jaw bone specific alteration by BP.	Benzo(a)pyrene	4-6	bone morphogenetic protein 2	Homo sapiens	24-29
25467232-14	2015	The BP-related impaired BMP-2-Msx-1-Dlx-5 axis might explain the jaw bone specific alteration by BP.	Benzo(a)pyrene	4-6	msh homeobox 1	Homo sapiens	30-35
25467232-14	2015	The BP-related impaired BMP-2-Msx-1-Dlx-5 axis might explain the jaw bone specific alteration by BP.	Benzo(a)pyrene	4-6	distal-less homeobox 5	Homo sapiens	36-41
25616380-5	2015	The concentration of benzo[a]pyrene, BaP, ranged from below detection limit to 0.08 ng/m(3) (KNUST) and 1.6 to 5.6 ng/m(3) (CC).	Benzo(a)pyrene	21-35	prohibitin 2	Homo sapiens	37-40
26166102-12	2015	In HLPC-UV, the amount of BaP and phenanthrene detected was lower for TB compared with SSB.	Benzo(a)pyrene	26-29	small RNA binding exonuclease protection factor La	Homo sapiens	87-90
25916804-11	2015	Furthermore, AS-IV reduced the production of reactive oxygen species, malondialdehyde, interleukin-1beta and tumor necrosis factor-alpha of the BaP-treated EPCs.	Benzo(a)pyrene	144-147	interleukin 1 beta	Homo sapiens	87-136
25916804-13	2015	SIGNIFICANCE: AS-IV is able to prevent BaP-mediated EPC dysfunction by at least inhibiting oxidative stress through the RAGE pathway.	Benzo(a)pyrene	39-42	MOK protein kinase	Homo sapiens	120-124
25805023-3	2015	In the present study, we investigated the impact of inhibition of Wnt/beta-catenin pathway on metabolism and genotoxicity of benzo[a]pyrene (BaP), a highly mutagenic polycyclic aromatic hydrocarbon and an efficient ligand of the aryl hydrocarbon receptor, which is known as a primary regulator of CYP1 expression, in cellular models derived from colorectal tumours.	Benzo(a)pyrene	141-144	catenin beta 1	Homo sapiens	70-82
26077025-4	2015	Using positional cloning, we found that a mutation in the Aspartate decarboxylase gene (BmADC) is causative in the bp mutant.	Benzo(a)pyrene	115-117	cysteine sulfinic acid decarboxylase	Bombyx mori	58-81
25805023-0	2015	Inhibition of beta-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation.	Benzo(a)pyrene	70-84	catenin beta 1	Homo sapiens	14-26
25805023-3	2015	In the present study, we investigated the impact of inhibition of Wnt/beta-catenin pathway on metabolism and genotoxicity of benzo[a]pyrene (BaP), a highly mutagenic polycyclic aromatic hydrocarbon and an efficient ligand of the aryl hydrocarbon receptor, which is known as a primary regulator of CYP1 expression, in cellular models derived from colorectal tumours.	Benzo(a)pyrene	125-139	catenin beta 1	Homo sapiens	70-82
25805023-4	2015	We observed that a synthetic inhibitor of beta-catenin, JW74, significantly increased formation of BaP-induced DNA adducts in both colorectal adenoma and carcinoma-derived cell lines.	Benzo(a)pyrene	99-102	catenin beta 1	Homo sapiens	42-54
25805023-5	2015	Using the short interfering RNA (siRNA) targeting beta-catenin, we then found that beta-catenin knockdown in HCT116 colon carcinoma cells significantly enhanced formation of covalent DNA adducts by BaP and histone H2AX phosphorylation, as detected by (32)P-postlabelling technique and immunocytochemistry, respectively, and it also induced expression of DNA damage response genes, such as CDKN1A or DDB2.	Benzo(a)pyrene	198-201	catenin beta 1	Homo sapiens	83-95
25805023-6	2015	The increased formation of DNA adducts formed by BaP upon beta-catenin knockdown corresponded with enhanced production of major BaP metabolites, as well as with an increased expression/activity of CYP1 enzymes.	Benzo(a)pyrene	49-52	catenin beta 1	Homo sapiens	58-70
25805023-6	2015	The increased formation of DNA adducts formed by BaP upon beta-catenin knockdown corresponded with enhanced production of major BaP metabolites, as well as with an increased expression/activity of CYP1 enzymes.	Benzo(a)pyrene	49-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	197-201
25805023-6	2015	The increased formation of DNA adducts formed by BaP upon beta-catenin knockdown corresponded with enhanced production of major BaP metabolites, as well as with an increased expression/activity of CYP1 enzymes.	Benzo(a)pyrene	128-131	catenin beta 1	Homo sapiens	58-70
25805023-7	2015	Finally, using siRNA-mediated knockdown of CYP1A1, we confirmed that this enzyme plays a major role in formation of BaP-induced DNA adducts in HCT116 cells.	Benzo(a)pyrene	116-119	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
25805023-8	2015	Taken together, the present results indicated that the siRNA-mediated inhibition of beta-catenin signalling, which is aberrantly activated in a majority of colorectal cancers, modulated genotoxicity of dietary carcinogen BaP in colon cell model in vitro, via a mechanism involving up-regulation of CYP1 expression and activity.	Benzo(a)pyrene	221-224	catenin beta 1	Homo sapiens	84-96
25805023-8	2015	Taken together, the present results indicated that the siRNA-mediated inhibition of beta-catenin signalling, which is aberrantly activated in a majority of colorectal cancers, modulated genotoxicity of dietary carcinogen BaP in colon cell model in vitro, via a mechanism involving up-regulation of CYP1 expression and activity.	Benzo(a)pyrene	221-224	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	298-302
27350804-0	2015	Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages.	Benzo(a)pyrene	65-79	glutamic pyruvic transaminase, soluble	Mus musculus	106-109
25896968-5	2015	In addition, TCDD and benzo(a)pyrene, two potent AhR ligands, also significantly increased mRNA expression of PDGF-B in M1 MPhi, whereas some weak ligands of AhR did not.	Benzo(a)pyrene	22-36	aryl hydrocarbon receptor	Homo sapiens	49-52
25896968-5	2015	In addition, TCDD and benzo(a)pyrene, two potent AhR ligands, also significantly increased mRNA expression of PDGF-B in M1 MPhi, whereas some weak ligands of AhR did not.	Benzo(a)pyrene	22-36	platelet derived growth factor subunit B	Homo sapiens	110-116
25896968-5	2015	In addition, TCDD and benzo(a)pyrene, two potent AhR ligands, also significantly increased mRNA expression of PDGF-B in M1 MPhi, whereas some weak ligands of AhR did not.	Benzo(a)pyrene	22-36	aryl hydrocarbon receptor	Homo sapiens	158-161
26023183-5	2015	Prdm8(EGFP/EGFP) mice showed nonprogressive b-wave deficits on electroretinograms, consistent with compromised BP cell function or circuitry resembling the incomplete form of human congenital stationary night blindness (CSNB).	Benzo(a)pyrene	111-113	PR domain containing 8	Mus musculus	0-5
25697175-12	2015	CEA levels may be a secondary marker for diagnosing BP.	Benzo(a)pyrene	52-54	CEA cell adhesion molecule 3	Homo sapiens	0-3
25532870-3	2015	Moderately strong AHR agonists, such as benzo[a]pyrene and beta-naphthoflavone, have been shown to cause similar cardiotoxic effects when coupled with a cytochrome P450 1A (CYP1A) inhibitor, such as fluoranthene (FL).	Benzo(a)pyrene	40-54	aryl hydrocarbon receptor 1a	Danio rerio	18-21
25532870-3	2015	Moderately strong AHR agonists, such as benzo[a]pyrene and beta-naphthoflavone, have been shown to cause similar cardiotoxic effects when coupled with a cytochrome P450 1A (CYP1A) inhibitor, such as fluoranthene (FL).	Benzo(a)pyrene	40-54	cytochrome P450, family 1, subfamily A	Danio rerio	153-171
25532870-3	2015	Moderately strong AHR agonists, such as benzo[a]pyrene and beta-naphthoflavone, have been shown to cause similar cardiotoxic effects when coupled with a cytochrome P450 1A (CYP1A) inhibitor, such as fluoranthene (FL).	Benzo(a)pyrene	40-54	cytochrome P450, family 1, subfamily A	Danio rerio	173-178
25632966-4	2015	Further, BP treatment also resulted in a significant increase in the enzyme activities of aryl hydrocarbon hydroxylase as well as drug-metabolizing enzymes, namely cytocrome P450 and cytochrome b5.	Benzo(a)pyrene	9-11	cytochrome b5 type A (microsomal)	Mus musculus	183-196
25632966-5	2015	On the other hand, reduced glutathione (GSH) levels, the activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione-S-transferase (GST) were found to be significantly decreased following BP treatment.	Benzo(a)pyrene	214-216	hematopoietic prostaglandin D synthase	Mus musculus	131-156
25632966-5	2015	On the other hand, reduced glutathione (GSH) levels, the activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione-S-transferase (GST) were found to be significantly decreased following BP treatment.	Benzo(a)pyrene	214-216	hematopoietic prostaglandin D synthase	Mus musculus	158-161
25632966-7	2015	Further, treatment of curcumin and resveratrol to BP-treated mice significantly elevated the activities of SOD, GR, and GST.	Benzo(a)pyrene	50-52	glutathione reductase	Mus musculus	112-114
25632966-7	2015	Further, treatment of curcumin and resveratrol to BP-treated mice significantly elevated the activities of SOD, GR, and GST.	Benzo(a)pyrene	50-52	hematopoietic prostaglandin D synthase	Mus musculus	120-123
26070056-3	2015	High Alt Biol Med 16:97-109, 2015.--Both aging and high altitude exposure may induce important changes in BP regulation, leading to significant increases in BP levels.	Benzo(a)pyrene	106-108	mediator complex subunit 16	Homo sapiens	14-20
26070056-3	2015	High Alt Biol Med 16:97-109, 2015.--Both aging and high altitude exposure may induce important changes in BP regulation, leading to significant increases in BP levels.	Benzo(a)pyrene	157-159	mediator complex subunit 16	Homo sapiens	14-20
25724555-10	2015	These data demonstrate that iRoot BP Plus can promote DPC migration and pulp repair involving the FGFR-mediated ERK 1/2, JNK, and Akt pathways.	Benzo(a)pyrene	34-36	mitogen-activated protein kinase 3	Homo sapiens	112-119
25724555-10	2015	These data demonstrate that iRoot BP Plus can promote DPC migration and pulp repair involving the FGFR-mediated ERK 1/2, JNK, and Akt pathways.	Benzo(a)pyrene	34-36	mitogen-activated protein kinase 8	Homo sapiens	121-124
25724555-10	2015	These data demonstrate that iRoot BP Plus can promote DPC migration and pulp repair involving the FGFR-mediated ERK 1/2, JNK, and Akt pathways.	Benzo(a)pyrene	34-36	AKT serine/threonine kinase 1	Homo sapiens	130-133
26120484-7	2015	RESULTS: In comparison with the control animals, animals in which benzo(a)pyrene had induced lung cancer showed significant increases in extracellular matrix components such as collagen (hydroxy proline), elastin, uronic acid and hexosamine and in glycosaminoglycans such as hyaluronate, chondroitin sulfate, keratan sulfate and dermatan sulfate.	Benzo(a)pyrene	66-80	elastin	Mus musculus	205-212
25971159-2	2015	Furthermore, a large number of studies have shown that aluminum (Al) and benzo[a]pyrene (BaP) are neurotoxic and target the central nervous system to cause neuronal apoptosis.	Benzo(a)pyrene	73-87	prohibitin 2	Homo sapiens	89-92
23406957-5	2015	The results reveal that silymarin possesses substantial protective effect against B(a)P-induced damages by inhibiting phase I detoxification enzyme CYP1A1 and modulating phase II conjugating enzymes, which were confirmed by histopathological analysis.	Benzo(a)pyrene	82-87	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	148-154
26035663-2	2015	This paper focused on the carcinogen benzo[a]pyrene (BaP) from industrial effluent and gaseous emissions, and established a multi-pathway exposure model based on a Level IV multimedia fugacity model to analyze the human health risks in a city that has undergone rapid industrialization.	Benzo(a)pyrene	37-51	prohibitin 2	Homo sapiens	53-56
25781201-6	2015	In contrast, AhR agonist and procarcinogen benzo[a]pyrene and its metabolite, 1,6-benzo[a]pyrene quinone, induced oxidative DNA damage and ROS formation, respectively, in MCF-10A cells.	Benzo(a)pyrene	43-57	aryl hydrocarbon receptor	Homo sapiens	13-16
25724548-0	2015	Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling.	Benzo(a)pyrene	23-37	mitogen-activated protein kinase 1	Homo sapiens	94-97
25724548-0	2015	Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling.	Benzo(a)pyrene	23-37	matrix metallopeptidase 9	Homo sapiens	98-102
25724548-6	2015	Specifically, we demonstrated that benzo[a]pyrene enhances breast cancer cell migration and invasion by up-regulating ROS-induced ERK signaling, leading to the activation of matrix metalloproteinases 9.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 1	Homo sapiens	130-133
25724548-7	2015	Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway.	Benzo(a)pyrene	25-39	mitogen-activated protein kinase 1	Homo sapiens	201-204
25724548-7	2015	Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway.	Benzo(a)pyrene	25-39	matrix metallopeptidase 9	Homo sapiens	205-209
25724548-7	2015	Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway.	Benzo(a)pyrene	144-158	mitogen-activated protein kinase 1	Homo sapiens	201-204
25724548-7	2015	Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway.	Benzo(a)pyrene	144-158	matrix metallopeptidase 9	Homo sapiens	205-209
25738754-1	2015	This is the first study to demonstrate that benzo(a)-pyrene (BaP) was able to enhance the production of parathyroid hormone-related protein (PTHrP) by human non-small cell lung cancer H460 cells.	Benzo(a)pyrene	44-59	prohibitin 2	Homo sapiens	61-64
25573074-1	2015	BACKGROUND AND PURPOSE: mu-Opioid receptors, pro-opiomelanocortin and pro-enkephalin are highly expressed in the nucleus tractus solitarii (NTS) and mu receptor agonists given to the NTS dose-dependently increased BP.	Benzo(a)pyrene	214-216	proopiomelanocortin	Rattus norvegicus	45-65
25573074-1	2015	BACKGROUND AND PURPOSE: mu-Opioid receptors, pro-opiomelanocortin and pro-enkephalin are highly expressed in the nucleus tractus solitarii (NTS) and mu receptor agonists given to the NTS dose-dependently increased BP.	Benzo(a)pyrene	214-216	proenkephalin	Rattus norvegicus	70-84
25738754-1	2015	This is the first study to demonstrate that benzo(a)-pyrene (BaP) was able to enhance the production of parathyroid hormone-related protein (PTHrP) by human non-small cell lung cancer H460 cells.	Benzo(a)pyrene	44-59	parathyroid hormone like hormone	Homo sapiens	104-139
25738754-1	2015	This is the first study to demonstrate that benzo(a)-pyrene (BaP) was able to enhance the production of parathyroid hormone-related protein (PTHrP) by human non-small cell lung cancer H460 cells.	Benzo(a)pyrene	44-59	parathyroid hormone like hormone	Homo sapiens	141-146
25753458-7	2015	We used a regression model to evaluate the effect of COMT genotype on the BP in the striatum and its sub-regions.	Benzo(a)pyrene	74-76	catechol-O-methyltransferase	Homo sapiens	53-57
26221921-11	2015	CONCLUSIONS: Our results for the first time suggested the DHFR 19-bp D/D genotype may confer a reduced risk of NS-CL/P and might act as a protective factor against NS-CL/P in the Iranian subjects.	Benzo(a)pyrene	66-68	dihydrofolate reductase	Homo sapiens	58-62
25991719-6	2015	Icv infusion of EO-binding Fab fragments also blocked the BP response in Nedd4-2(-/-) mice.	Benzo(a)pyrene	58-60	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	73-80
25864997-8	2015	Serum NGAL concentration showed significant correlation with overall ambulatory BP levels both in non-dipper and dipper HP groups.	Benzo(a)pyrene	80-82	lipocalin 2	Homo sapiens	6-10
25860963-8	2015	Diesel exhaust particle (DEP)-PAH and Benzo[a]Pyrene (B[a]P) stimulation further increased IL-22 but decreased IL-17A production in both groups.	Benzo(a)pyrene	38-52	interleukin 22	Homo sapiens	91-96
25860963-8	2015	Diesel exhaust particle (DEP)-PAH and Benzo[a]Pyrene (B[a]P) stimulation further increased IL-22 but decreased IL-17A production in both groups.	Benzo(a)pyrene	38-52	interleukin 17A	Homo sapiens	111-117
25864997-9	2015	CONCLUSION: Serum NGAL concentrations increased significantly in non-dipper HT patients in comparison with dipper HT patients and normotensive patients and show significant correlation with ambulatory BP levels.	Benzo(a)pyrene	201-203	lipocalin 2	Homo sapiens	18-22
26041267-8	2015	The MOA includes: (1) BaP binding to the aryl hydrocarbon receptor (AHR); (2) AHR-dependent modulation of the transcription of N-methyl-d-aspartate glutamate receptor (NMDAR) subunits; (3) NMDAR-mediated loss of neuronal activity and decreased long-term potentiation; and (4) compromised learning and memory.	Benzo(a)pyrene	22-25	aryl hydrocarbon receptor	Homo sapiens	41-66
26028820-10	2015	In mice exposed to BP/DSS, beta-catenin was demonstrated immunohistochemically in the nucleus and/or cytoplasm of the tumor cells, and this translocation from the cell membrane was evident in subsets of dysplastic foci.	Benzo(a)pyrene	19-21	catenin (cadherin associated protein), beta 1	Mus musculus	27-39
26028820-12	2015	These finding suggest that aberrant beta-catenin accumulation in dysplastic foci is associated with tumor progression in this BP/DSS model.	Benzo(a)pyrene	126-128	catenin (cadherin associated protein), beta 1	Mus musculus	36-48
25775254-9	2015	Based on these findings, we conclude that BP independent monotherapy of ETA receptor antagonist attenuates the progression of CKD and significantly mitigates CVD independent of RAS inhibition.	Benzo(a)pyrene	42-44	endothelin receptor type A	Rattus norvegicus	72-75
25822547-3	2015	In this study, we showed that BP directly interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA (BRM) both in vitro and in vivo.	Benzo(a)pyrene	30-32	switch 2	Arabidopsis thaliana	61-65
25822547-3	2015	In this study, we showed that BP directly interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA (BRM) both in vitro and in vivo.	Benzo(a)pyrene	30-32	switch 2	Arabidopsis thaliana	66-70
25822547-3	2015	In this study, we showed that BP directly interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA (BRM) both in vitro and in vivo.	Benzo(a)pyrene	30-32	transcription regulatory protein SNF2	Arabidopsis thaliana	107-110
25822547-8	2015	Taken together, our results indicate that BP interacts with the chromatin remodeling factor BRM to regulate the expression of KNAT2 and KNAT6 in control of inflorescence architecture.	Benzo(a)pyrene	42-44	transcription regulatory protein SNF2	Arabidopsis thaliana	92-95
25822547-8	2015	Taken together, our results indicate that BP interacts with the chromatin remodeling factor BRM to regulate the expression of KNAT2 and KNAT6 in control of inflorescence architecture.	Benzo(a)pyrene	42-44	homeobox knotted-like protein	Arabidopsis thaliana	126-131
25822547-8	2015	Taken together, our results indicate that BP interacts with the chromatin remodeling factor BRM to regulate the expression of KNAT2 and KNAT6 in control of inflorescence architecture.	Benzo(a)pyrene	42-44	homeobox protein knotted-1-like 6	Arabidopsis thaliana	136-141
25693888-0	2015	Hyaluronic acid-fabricated nanogold delivery of the inhibitor of apoptosis protein-2 siRNAs inhibits benzo[a]pyrene-induced oncogenic properties of lung cancer A549 cells.	Benzo(a)pyrene	101-115	baculoviral IAP repeat containing 2	Homo sapiens	52-84
25655200-8	2015	BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs.	Benzo(a)pyrene	0-2	AKT serine/threonine kinase 1	Homo sapiens	46-49
25655200-8	2015	BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs.	Benzo(a)pyrene	0-2	mitogen-activated protein kinase 3	Homo sapiens	54-61
25655200-8	2015	BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs.	Benzo(a)pyrene	0-2	mitogen-activated protein kinase 8	Homo sapiens	63-66
25655200-8	2015	BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs.	Benzo(a)pyrene	0-2	mitogen-activated protein kinase 1	Homo sapiens	71-74
25693888-1	2015	Benzo[a]pyrene (BaP), a component of cooking oil fumes (COF), promotes lung cancer cell proliferation and survival via the induction of inhibitor of apoptosis protein-2 (IAP-2) proteins.	Benzo(a)pyrene	0-14	baculoviral IAP repeat containing 2	Homo sapiens	136-168
25693888-1	2015	Benzo[a]pyrene (BaP), a component of cooking oil fumes (COF), promotes lung cancer cell proliferation and survival via the induction of inhibitor of apoptosis protein-2 (IAP-2) proteins.	Benzo(a)pyrene	0-14	baculoviral IAP repeat containing 2	Homo sapiens	170-175
25693888-1	2015	Benzo[a]pyrene (BaP), a component of cooking oil fumes (COF), promotes lung cancer cell proliferation and survival via the induction of inhibitor of apoptosis protein-2 (IAP-2) proteins.	Benzo(a)pyrene	16-19	baculoviral IAP repeat containing 2	Homo sapiens	136-168
25693888-1	2015	Benzo[a]pyrene (BaP), a component of cooking oil fumes (COF), promotes lung cancer cell proliferation and survival via the induction of inhibitor of apoptosis protein-2 (IAP-2) proteins.	Benzo(a)pyrene	16-19	baculoviral IAP repeat containing 2	Homo sapiens	170-175
25693888-8	2015	Incubation of BaP-challenged cells with AuNP-HA-IAP-2 siRNAs silenced the expression of IAP-2, decreased cell proliferation and triggered pronounced cell apoptosis by the decrease in Bcl-2 protein and the increase in Bax protein as well as the active form of caspases-3.	Benzo(a)pyrene	14-17	baculoviral IAP repeat containing 2	Homo sapiens	48-53
25693888-8	2015	Incubation of BaP-challenged cells with AuNP-HA-IAP-2 siRNAs silenced the expression of IAP-2, decreased cell proliferation and triggered pronounced cell apoptosis by the decrease in Bcl-2 protein and the increase in Bax protein as well as the active form of caspases-3.	Benzo(a)pyrene	14-17	baculoviral IAP repeat containing 2	Homo sapiens	88-93
25693888-8	2015	Incubation of BaP-challenged cells with AuNP-HA-IAP-2 siRNAs silenced the expression of IAP-2, decreased cell proliferation and triggered pronounced cell apoptosis by the decrease in Bcl-2 protein and the increase in Bax protein as well as the active form of caspases-3.	Benzo(a)pyrene	14-17	BCL2 apoptosis regulator	Homo sapiens	183-188
25693888-8	2015	Incubation of BaP-challenged cells with AuNP-HA-IAP-2 siRNAs silenced the expression of IAP-2, decreased cell proliferation and triggered pronounced cell apoptosis by the decrease in Bcl-2 protein and the increase in Bax protein as well as the active form of caspases-3.	Benzo(a)pyrene	14-17	BCL2 associated X, apoptosis regulator	Homo sapiens	217-220
25693888-9	2015	The BaP-elicited cell migration and enzymatic activity of the secreted matrix metalloproteinase-2 were also substantially suppressed by treatment with AuNP-HA-IAP-2 siRNAs.	Benzo(a)pyrene	4-7	matrix metallopeptidase 2	Homo sapiens	71-97
25693888-9	2015	The BaP-elicited cell migration and enzymatic activity of the secreted matrix metalloproteinase-2 were also substantially suppressed by treatment with AuNP-HA-IAP-2 siRNAs.	Benzo(a)pyrene	4-7	baculoviral IAP repeat containing 2	Homo sapiens	159-164
25359171-2	2015	BP treatment resulted in a significant increase in the protein expression of Bcl-2 whereas expression of Bax was significantly decreased.	Benzo(a)pyrene	0-2	B cell leukemia/lymphoma 2	Mus musculus	77-82
25516082-8	2015	RESULT(S): The BaP-treated zygotes exhibited significantly higher reactive oxygen species activity, which might lead to more cell apoptosis, low ratio of Nanog- or Oct4-positive ICM cells, and increasing DNA damage in both genomic and telomeric DNA in blastocysts.	Benzo(a)pyrene	15-18	Nanog homeobox	Mus musculus	154-160
25516082-8	2015	RESULT(S): The BaP-treated zygotes exhibited significantly higher reactive oxygen species activity, which might lead to more cell apoptosis, low ratio of Nanog- or Oct4-positive ICM cells, and increasing DNA damage in both genomic and telomeric DNA in blastocysts.	Benzo(a)pyrene	15-18	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	164-168
25490995-1	2015	Benzo(a)pyrene [B(a)P] is ubiquitous in the environment.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-21
25769181-0	2015	Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	57-60
25769181-0	2015	Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells.	Benzo(a)pyrene	0-14	checkpoint kinase 1	Homo sapiens	69-73
25847421-5	2015	We found that Xpa-Null Hupki mice, and HUFs derived from them, were more sensitive to the environmental carcinogen benzo[a]pyrene (BaP) than their wild-type (Xpa-WT) counterparts.	Benzo(a)pyrene	115-129	xeroderma pigmentosum, complementation group A	Mus musculus	14-17
25847421-5	2015	We found that Xpa-Null Hupki mice, and HUFs derived from them, were more sensitive to the environmental carcinogen benzo[a]pyrene (BaP) than their wild-type (Xpa-WT) counterparts.	Benzo(a)pyrene	131-134	xeroderma pigmentosum, complementation group A	Mus musculus	14-17
25626088-1	2015	A solid solution of a 75:25 mixture of tetrabenzoporphyrin (BP) and dichloroacenaphtho[q]tribenzo[b,g,l]porphyrin (CABP) forms when they are generated in a matrix of (dimethyl(o-anisyl)silylmethyl)(dimethylphenylsilylmethyl)[60]fullerene.	Benzo(a)pyrene	60-62	S100 calcium binding protein G	Homo sapiens	115-119
25536409-0	2015	Spectral overlap-free quantum dot-based determination of benzo[a]pyrene-induced cancer stem cells by concurrent monitoring of CD44, CD24 and aldehyde dehydrogenase 1.	Benzo(a)pyrene	57-71	CD44 molecule (Indian blood group)	Homo sapiens	126-130
25536409-0	2015	Spectral overlap-free quantum dot-based determination of benzo[a]pyrene-induced cancer stem cells by concurrent monitoring of CD44, CD24 and aldehyde dehydrogenase 1.	Benzo(a)pyrene	57-71	CD24 molecule	Homo sapiens	132-136
25536409-0	2015	Spectral overlap-free quantum dot-based determination of benzo[a]pyrene-induced cancer stem cells by concurrent monitoring of CD44, CD24 and aldehyde dehydrogenase 1.	Benzo(a)pyrene	57-71	aldehyde dehydrogenase 1 family member A1	Homo sapiens	141-165
25489928-0	2015	Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital.	Benzo(a)pyrene	155-169	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	77-109
25489928-0	2015	Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital.	Benzo(a)pyrene	155-169	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	111-114
25489928-0	2015	Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital.	Benzo(a)pyrene	155-169	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	116-121
25489928-3	2015	The current study shows that benzo[a]pyrene, a frequent contaminant of processed food and activator of the arylhydrocarbon receptor (AhR) activated the promoter and induced the transcription of the nuclear receptor constitutive androstane receptor (CAR, NR1I3) in rat hepatocytes.	Benzo(a)pyrene	29-43	aryl hydrocarbon receptor	Rattus norvegicus	133-136
25489928-3	2015	The current study shows that benzo[a]pyrene, a frequent contaminant of processed food and activator of the arylhydrocarbon receptor (AhR) activated the promoter and induced the transcription of the nuclear receptor constitutive androstane receptor (CAR, NR1I3) in rat hepatocytes.	Benzo(a)pyrene	29-43	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	215-247
25489928-3	2015	The current study shows that benzo[a]pyrene, a frequent contaminant of processed food and activator of the arylhydrocarbon receptor (AhR) activated the promoter and induced the transcription of the nuclear receptor constitutive androstane receptor (CAR, NR1I3) in rat hepatocytes.	Benzo(a)pyrene	29-43	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	249-252
25489928-3	2015	The current study shows that benzo[a]pyrene, a frequent contaminant of processed food and activator of the arylhydrocarbon receptor (AhR) activated the promoter and induced the transcription of the nuclear receptor constitutive androstane receptor (CAR, NR1I3) in rat hepatocytes.	Benzo(a)pyrene	29-43	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	254-259
25489928-7	2015	By inducing the AhR, phenobarbital enhanced the benzo[a]pyrene-dependent reduction of thyroid hormone half-life and the benzo[a]pyrene-dependent increase in the rate of thyroid hormone glucuronide formation in hepatocyte cultures.	Benzo(a)pyrene	48-62	aryl hydrocarbon receptor	Rattus norvegicus	16-19
25489928-7	2015	By inducing the AhR, phenobarbital enhanced the benzo[a]pyrene-dependent reduction of thyroid hormone half-life and the benzo[a]pyrene-dependent increase in the rate of thyroid hormone glucuronide formation in hepatocyte cultures.	Benzo(a)pyrene	120-134	aryl hydrocarbon receptor	Rattus norvegicus	16-19
25359171-3	2015	Further, BP treatment brought about a significant decrease in the activities of caspase 3, caspase 9 as well as the number of apoptotic cells.	Benzo(a)pyrene	9-11	caspase 3	Mus musculus	80-89
25359171-3	2015	Further, BP treatment brought about a significant decrease in the activities of caspase 3, caspase 9 as well as the number of apoptotic cells.	Benzo(a)pyrene	9-11	caspase 9	Mus musculus	91-100
25359171-4	2015	Interestingly, separate as well as combined supplementation of curcumin (60 mg/kg body weight) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-2 but caused a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.	Benzo(a)pyrene	135-137	B cell leukemia/lymphoma 2	Mus musculus	218-223
25359171-4	2015	Interestingly, separate as well as combined supplementation of curcumin (60 mg/kg body weight) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-2 but caused a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.	Benzo(a)pyrene	135-137	BCL2-associated X protein	Mus musculus	287-290
25359171-5	2015	Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment.	Benzo(a)pyrene	64-66	caspase 9	Mus musculus	142-151
25359171-5	2015	Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment.	Benzo(a)pyrene	64-66	caspase 3	Mus musculus	163-172
25230394-2	2015	At 2 muM, BaP induced Cyp1a1 expression in MEFs to a much greater extent than in ES cells and formed 45 times more adducts.	Benzo(a)pyrene	10-13	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	22-28
25635684-14	2015	Moreover, Bet v 1 was able to induce Erk1/2 and p38 MAPK activation in BP allergics but only a slight p38 activation in normal donors.	Benzo(a)pyrene	71-73	delta/notch like EGF repeat containing	Homo sapiens	10-13
25635684-14	2015	Moreover, Bet v 1 was able to induce Erk1/2 and p38 MAPK activation in BP allergics but only a slight p38 activation in normal donors.	Benzo(a)pyrene	71-73	mitogen-activated protein kinase 3	Homo sapiens	37-43
25635684-14	2015	Moreover, Bet v 1 was able to induce Erk1/2 and p38 MAPK activation in BP allergics but only a slight p38 activation in normal donors.	Benzo(a)pyrene	71-73	mitogen-activated protein kinase 1	Homo sapiens	48-51
24875192-5	2015	The coordinated regulation of ENaC by aldosterone, and AQP2 by arginine vasopressin (AVP) in principal cells is essential for the control of plasma Na(+) and K(+) concentrations, extracellular fluid volume, and BP.	Benzo(a)pyrene	211-213	arginine vasopressin	Homo sapiens	72-83
25251150-1	2015	Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk.	Benzo(a)pyrene	57-72	LOC522736	Bos taurus	101-126
24875192-5	2015	The coordinated regulation of ENaC by aldosterone, and AQP2 by arginine vasopressin (AVP) in principal cells is essential for the control of plasma Na(+) and K(+) concentrations, extracellular fluid volume, and BP.	Benzo(a)pyrene	211-213	aquaporin 2	Homo sapiens	55-59
25251150-1	2015	Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk.	Benzo(a)pyrene	57-72	LOC522736	Bos taurus	128-131
25261590-2	2015	An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse.	Benzo(a)pyrene	47-61	albumin	Homo sapiens	145-158
25261590-2	2015	An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse.	Benzo(a)pyrene	47-61	albumin	Homo sapiens	160-162
25261590-2	2015	An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse.	Benzo(a)pyrene	47-61	albumin	Homo sapiens	211-213
25261590-2	2015	An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse.	Benzo(a)pyrene	63-65	albumin	Homo sapiens	145-158
25261590-2	2015	An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse.	Benzo(a)pyrene	63-65	albumin	Homo sapiens	160-162
25261590-2	2015	An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse.	Benzo(a)pyrene	63-65	albumin	Homo sapiens	211-213
25854346-0	2015	Inhibitory effect of phenethyl isothiocyanate against benzo[a] pyrene-induced rise in CYP1A1 mRNA and apoprotein levels as its chemopreventive properties.	Benzo(a)pyrene	54-69	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	86-92
25854346-4	2015	OBJECTIVE: To evaluate the inhibitory effects of PEITC against benzo[a]pyrene-induced rise in rat liver CYP1A1 mRNA and apoprotein levels.	Benzo(a)pyrene	63-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	104-110
25050869-9	2015	PEDF values showed a positive correlation with microalbumin/creatinine, hb A1c, FBS, systolic and diastolic BP levels.	Benzo(a)pyrene	108-110	serpin family F member 1	Homo sapiens	0-4
25605027-5	2015	2014 ), we present a case study evaluating the utility of toxicogenomics in the RA of benzo[a]pyrene (BaP), a known human carcinogen.	Benzo(a)pyrene	86-100	prohibitin 2	Homo sapiens	102-105
26004618-7	2015	RESULTS: The BP treatment resulted in a significant increase in LPO and ROS levels.	Benzo(a)pyrene	13-15	lactoperoxidase	Mus musculus	64-67
26004618-9	2015	Further, BP treatment brought about a significant increase in the activities of drug metabolizing enzymes (cytochrome P450 and b5).	Benzo(a)pyrene	9-11	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	107-129
26898094-9	2015	The second group of patients, following nephroprotection recommendations and LPD without KA/AA, had fewer reductions in BP without reaching the target level, DBP did not change; reduction of proteinuria was less significant than in group 1.	Benzo(a)pyrene	120-122	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	77-80
25628927-5	2015	We explored this question in a PARG-deficient human bronchial epithelial cell line (shPARG cells) treated with various concentration of BaP for 15 weeks.	Benzo(a)pyrene	136-139	poly(ADP-ribose) glycohydrolase	Homo sapiens	31-35
26410488-5	2015	Both outer loop and inner loop employ BP Neural Network tuned PID algorithm.	Benzo(a)pyrene	38-40	metastasis associated 1 family member 2	Homo sapiens	62-65
25628927-9	2015	We found that PARG silencing could dramatically inhibit BaP-induced cell malignancy of human bronchial epithelial cells in soft agar assay.	Benzo(a)pyrene	56-59	poly(ADP-ribose) glycohydrolase	Homo sapiens	14-18
25628927-13	2015	This is the first experimental demonstration of a link between PARG silencing and reduced cell migration after BaP exposure.	Benzo(a)pyrene	111-114	poly(ADP-ribose) glycohydrolase	Homo sapiens	63-67
25451572-0	2014	The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.	Benzo(a)pyrene	85-99	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	32-37
25451572-0	2014	The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.	Benzo(a)pyrene	85-99	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	42-47
25451572-5	2014	As a consequence, [(3)H]BP concentrations were in general higher in the plasma and in most of the organs of the Abcg2 and Abcc2 knockout mice.	Benzo(a)pyrene	24-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	112-117
25451572-5	2014	As a consequence, [(3)H]BP concentrations were in general higher in the plasma and in most of the organs of the Abcg2 and Abcc2 knockout mice.	Benzo(a)pyrene	24-26	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	122-127
25451572-7	2014	Subjects with reduced ABCG2 or ABCC2 expression might have higher oral bioavailability for BP due to a reduced excretion and so might be more susceptible to BP-induced carcinogenesis.	Benzo(a)pyrene	91-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	22-27
25451572-7	2014	Subjects with reduced ABCG2 or ABCC2 expression might have higher oral bioavailability for BP due to a reduced excretion and so might be more susceptible to BP-induced carcinogenesis.	Benzo(a)pyrene	91-93	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	31-36
25451572-7	2014	Subjects with reduced ABCG2 or ABCC2 expression might have higher oral bioavailability for BP due to a reduced excretion and so might be more susceptible to BP-induced carcinogenesis.	Benzo(a)pyrene	157-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	22-27
25451572-7	2014	Subjects with reduced ABCG2 or ABCC2 expression might have higher oral bioavailability for BP due to a reduced excretion and so might be more susceptible to BP-induced carcinogenesis.	Benzo(a)pyrene	157-159	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	31-36
25319350-7	2014	Moreover, a precocious expression of Runx2 (at 7 days) was observed in PCL-AT-BP in combination with osteogenic soluble factors suggesting that BP controls better than HA the osteogenic maturation process in bone substitutes.	Benzo(a)pyrene	78-80	RUNX family transcription factor 2	Rattus norvegicus	37-42
25196082-7	2014	The second most toxic fraction contained known AhR agonists (e.g., benzo[a]pyrene and indeno[1,2,3-cd]pyrene).	Benzo(a)pyrene	67-81	aryl hydrocarbon receptor 1a	Danio rerio	47-50
25275945-9	2014	Ki67 staining was reduced in rolipram-treated mice compared with benzo(a)pyrene-treated mice.	Benzo(a)pyrene	65-79	antigen identified by monoclonal antibody Ki 67	Mus musculus	0-4
25275945-11	2014	Rolipram significantly attenuated NF-kappaB and Nrf2 expression in benzo(a)pyrene-induced lung cancer tissues.	Benzo(a)pyrene	67-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52
23994263-0	2014	Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	174-178
25275945-12	2014	CONCLUSIONS: In vivo experiments in the benzo(a)pyrene-induced model of lung cancer show that PDE4 inhibition significant inhibits lung carcinogenesis.	Benzo(a)pyrene	40-54	phosphodiesterase 4A	Homo sapiens	94-98
25336021-2	2014	Carboxylate-substituted pillar[6]arene (CPA[6])-valved mesoporous silica nanoparticles (MSNs) functionalized with dimethylbenzimidazolium (DMBI) and bipyridinium (BP) stalks were constructed, respectively, for multiresponsive controlled release.	Benzo(a)pyrene	163-165	carboxypeptidase A6	Homo sapiens	40-45
25336021-3	2014	CPA[6] encircled the DMBI or BP stalks to develop supramolecular nanovalves for encapsulation of cargo within the MSN pores.	Benzo(a)pyrene	29-31	carboxypeptidase A6	Homo sapiens	0-5
25411724-1	2014	Cigarette smoke is a known source of exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), especially benzo[a]pyrene (BaP).	Benzo(a)pyrene	114-128	prohibitin 2	Homo sapiens	130-133
25401702-11	2014	IFN-gamma HO and HE mice, however, had higher enterobacteria and BP loads, but lacked bifidobacteria when kept in OC versus IVC, as was the case in HO and HE Rag1 mice.	Benzo(a)pyrene	65-67	interferon gamma	Mus musculus	0-9
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	237-251	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	61-67
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	237-251	tumor necrosis factor	Mus musculus	103-130
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	237-251	tumor necrosis factor	Mus musculus	132-141
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	237-251	aryl-hydrocarbon receptor	Mus musculus	151-176
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	253-256	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	61-67
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	253-256	tumor necrosis factor	Mus musculus	103-130
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	253-256	tumor necrosis factor	Mus musculus	132-141
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	253-256	aryl-hydrocarbon receptor	Mus musculus	151-176
25233930-6	2014	The inhibition of the P-TEFb subunit, cyclin-dependent kinase 9 (CDK9), which phosphorylates RNA polymerase II (RNAPII), prevented the enhanced CYP1B1 induction by a combination of BaP and inflammatory cytokine.	Benzo(a)pyrene	181-184	cyclin-dependent kinase 9 (CDC2-related kinase)	Mus musculus	38-63
25233930-6	2014	The inhibition of the P-TEFb subunit, cyclin-dependent kinase 9 (CDK9), which phosphorylates RNA polymerase II (RNAPII), prevented the enhanced CYP1B1 induction by a combination of BaP and inflammatory cytokine.	Benzo(a)pyrene	181-184	cyclin-dependent kinase 9 (CDC2-related kinase)	Mus musculus	65-69
25233930-6	2014	The inhibition of the P-TEFb subunit, cyclin-dependent kinase 9 (CDK9), which phosphorylates RNA polymerase II (RNAPII), prevented the enhanced CYP1B1 induction by a combination of BaP and inflammatory cytokine.	Benzo(a)pyrene	181-184	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	144-150
25233930-7	2014	Furthermore, using chromatin immunoprecipitation assays, we found that cotreatment of epithelial cells with TNF-alpha and BaP resulted in enhanced recruitment of both CDK9 and RNAPII to the Cyp1b1 gene promoter.	Benzo(a)pyrene	122-125	cyclin-dependent kinase 9 (CDC2-related kinase)	Mus musculus	167-171
25233930-7	2014	Furthermore, using chromatin immunoprecipitation assays, we found that cotreatment of epithelial cells with TNF-alpha and BaP resulted in enhanced recruitment of both CDK9 and RNAPII to the Cyp1b1 gene promoter.	Benzo(a)pyrene	122-125	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	190-196
25241944-5	2014	Using the USEPA toxic equivalency factor (TEF) approach: Benzo(a)Pyrene and Dibenzo(a,h)Anthracene contributed highly carcinogenic exposure equivalent.	Benzo(a)pyrene	57-71	TEF transcription factor, PAR bZIP family member	Homo sapiens	42-45
25199627-5	2014	First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia.	Benzo(a)pyrene	7-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	105-111
25199627-5	2014	First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia.	Benzo(a)pyrene	7-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	116-122
25199627-5	2014	First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia.	Benzo(a)pyrene	7-10	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	169-175
25199627-5	2014	First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia.	Benzo(a)pyrene	7-10	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	180-186
25245543-0	2014	Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene.	Benzo(a)pyrene	154-168	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-26
25245543-5	2014	In cells exposed to 4.0 microM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1.	Benzo(a)pyrene	31-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	77-83
25245543-5	2014	In cells exposed to 4.0 microM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1.	Benzo(a)pyrene	31-33	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	100-106
25245543-5	2014	In cells exposed to 4.0 microM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1.	Benzo(a)pyrene	31-33	NAD(P)H quinone dehydrogenase 1	Homo sapiens	126-130
25245543-7	2014	In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not.	Benzo(a)pyrene	15-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
25245543-7	2014	In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not.	Benzo(a)pyrene	15-17	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	90-96
25245543-7	2014	In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not.	Benzo(a)pyrene	15-17	NAD(P)H quinone dehydrogenase 1	Homo sapiens	101-105
25245543-10	2014	Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn.	Benzo(a)pyrene	73-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166
25178717-7	2014	Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR(+/+) fibroblasts concomitant with decreased AhR protein levels.	Benzo(a)pyrene	25-39	aryl-hydrocarbon receptor	Mus musculus	12-15
24657529-2	2014	In this study, we tested the hypothesis that prenatal exposure of rats to benzo[a]pyrene (BP), a component of cigarette smoke, will result in increased susceptibility of newborns to oxygen-mediated lung injury and alveolar simplification, and that cytochrome P450 (CYP)1A and 1B1 enzymes and oxidative stress mechanistically contribute to this phenomenon.	Benzo(a)pyrene	74-88	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	248-279
24657529-2	2014	In this study, we tested the hypothesis that prenatal exposure of rats to benzo[a]pyrene (BP), a component of cigarette smoke, will result in increased susceptibility of newborns to oxygen-mediated lung injury and alveolar simplification, and that cytochrome P450 (CYP)1A and 1B1 enzymes and oxidative stress mechanistically contribute to this phenomenon.	Benzo(a)pyrene	90-92	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	248-279
24657529-5	2014	Prenatal exposure to BP, followed by hyperoxia, also resulted in significant modulation of hepatic and pulmonary cytochrome P450 (CYP)1A and 1B1 enzymes at PND 7-14.	Benzo(a)pyrene	21-23	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	113-144
23994263-5	2014	More importantly, although E5M was less active than L in inhibiting proliferation of MCF7 cells, when the cells were pretreated with the CYP1 inducer Benzo[a]pyrene (BaP) the potency of E5M was augmented.	Benzo(a)pyrene	150-164	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	137-141
23994263-5	2014	More importantly, although E5M was less active than L in inhibiting proliferation of MCF7 cells, when the cells were pretreated with the CYP1 inducer Benzo[a]pyrene (BaP) the potency of E5M was augmented.	Benzo(a)pyrene	166-169	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	137-141
23994263-7	2014	E5M1 production in BaP-induced MCF7 cells was attenuated in the presence of the CYP1A1 inhibitor alpha-napthoflavone.	Benzo(a)pyrene	19-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
23994263-10	2014	E5M antiproliferative effect in BaP pretreated cells was attenuated in the presence of the CYP1A1 inhibitor alpha-napthoflavone, as demonstrated by Western blotting and FACS analysis.	Benzo(a)pyrene	32-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	91-97
23994263-11	2014	Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1.	Benzo(a)pyrene	44-47	H3 histone pseudogene 16	Homo sapiens	130-133
23994263-11	2014	Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1.	Benzo(a)pyrene	44-47	mitogen-activated protein kinase 8	Homo sapiens	135-138
23994263-11	2014	Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1.	Benzo(a)pyrene	44-47	mitogen-activated protein kinase 8	Homo sapiens	145-148
23994263-11	2014	Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1.	Benzo(a)pyrene	44-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	189-193
24291350-7	2014	Prenatal BaP exposure significantly increased visceral adipose tissue weight, weight gain between 3 weeks and 7.5 months of age, hepatic lipid content measured by oil red O staining, and hepatic fatty acid beta-oxidation gene expression in Gclm(+/+), but not in Gclm(-/-), female offspring.	Benzo(a)pyrene	9-12	glutamate-cysteine ligase, modifier subunit	Mus musculus	240-244
24291350-7	2014	Prenatal BaP exposure significantly increased visceral adipose tissue weight, weight gain between 3 weeks and 7.5 months of age, hepatic lipid content measured by oil red O staining, and hepatic fatty acid beta-oxidation gene expression in Gclm(+/+), but not in Gclm(-/-), female offspring.	Benzo(a)pyrene	9-12	glutamate-cysteine ligase, modifier subunit	Mus musculus	262-266
23625689-7	2014	Two other AHR ligands, 6-formylindolo[3,2-b]carbazole and benzo(a)pyrene (BP) also elicited similar responses.	Benzo(a)pyrene	58-72	aryl hydrocarbon receptor	Homo sapiens	10-13
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	tubulin, beta 5 class I	Mus musculus	103-108
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	FBJ osteosarcoma oncogene	Mus musculus	110-113
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	cadherin 1	Mus musculus	115-119
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-127
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	APC, WNT signaling pathway regulator	Mus musculus	129-132
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	myelocytomatosis oncogene	Mus musculus	134-137
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	catenin (cadherin associated protein), beta 1	Mus musculus	139-145
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	caveolin 1, caveolae protein	Mus musculus	150-153
25297811-9	2014	However, mechanisms related to early changes in p53, Stat3 and Wnt/beta-catenin pathways may play roles in defining BaP organotropism.	Benzo(a)pyrene	116-119	transformation related protein 53	Mus musculus	48-51
25297811-9	2014	However, mechanisms related to early changes in p53, Stat3 and Wnt/beta-catenin pathways may play roles in defining BaP organotropism.	Benzo(a)pyrene	116-119	catenin (cadherin associated protein), beta 1	Mus musculus	67-79
25396135-2	2014	Neurodegenerative processes (viz., stroke, dementia, Parkinsonism, epilepsy, etc) uncover BPAg1-n, an alternatively spliced form of BPAg1-e that stabilizes the cytoskeleton of sensory neurons, generating autoantibodies that may subsequently lead to BP by cross-reacting with BPAg1-e. We present a patient with Parkinsonism who later developed blisters, erosions and crusts localized to the palms and soles, confirmed histopathologically as bullous pemphigoid.	Benzo(a)pyrene	90-92	dystonin	Homo sapiens	132-137
25396135-2	2014	Neurodegenerative processes (viz., stroke, dementia, Parkinsonism, epilepsy, etc) uncover BPAg1-n, an alternatively spliced form of BPAg1-e that stabilizes the cytoskeleton of sensory neurons, generating autoantibodies that may subsequently lead to BP by cross-reacting with BPAg1-e. We present a patient with Parkinsonism who later developed blisters, erosions and crusts localized to the palms and soles, confirmed histopathologically as bullous pemphigoid.	Benzo(a)pyrene	90-92	dystonin	Homo sapiens	132-137
23625689-7	2014	Two other AHR ligands, 6-formylindolo[3,2-b]carbazole and benzo(a)pyrene (BP) also elicited similar responses.	Benzo(a)pyrene	74-76	aryl hydrocarbon receptor	Homo sapiens	10-13
24828609-6	2014	Blood pressure parameters were similar between the two groups; however, ARPKD patients required a significantly greater number of antihypertensive medications to achieve similar BP levels.	Benzo(a)pyrene	178-180	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	72-77
25195819-6	2014	Further investigation revealed PARG silencing protected DNA methyltransferases (DNMTs) activity from change by BaP exposure.	Benzo(a)pyrene	111-114	poly(ADP-ribose) glycohydrolase	Homo sapiens	31-35
25039392-8	2014	In addition, the NTT protein is able to bind the BP promoter in yeast, and when this binding region is not present, NTT fails to activate BP in the replum.	Benzo(a)pyrene	49-51	C2H2-type zinc finger family protein	Arabidopsis thaliana	17-20
25195819-0	2014	Role of poly(ADP-ribose) glycohydrolase silencing in DNA hypomethylation induced by benzo(a)pyrene.	Benzo(a)pyrene	84-98	poly(ADP-ribose) glycohydrolase	Homo sapiens	8-39
25195819-7	2014	Interestingly, Dnmt1 is PARylated in PARG-null cells after BaP exposure.	Benzo(a)pyrene	59-62	DNA methyltransferase 1	Homo sapiens	15-20
25195819-7	2014	Interestingly, Dnmt1 is PARylated in PARG-null cells after BaP exposure.	Benzo(a)pyrene	59-62	poly(ADP-ribose) glycohydrolase	Homo sapiens	37-41
25195819-8	2014	The results show a role for PARG silencing in DNA hypomethylation induced by BaP that may provide new clue for cancer therapy.	Benzo(a)pyrene	77-80	poly(ADP-ribose) glycohydrolase	Homo sapiens	28-32
25148552-7	2014	Notably, we show that N-clasp flexibility depends on lesion topology, being markedly reduced in the case of the benzo[a]pyrene-derived major adduct to N(2)-dG, whose bypass by Polkappa is nearly error-free.	Benzo(a)pyrene	112-126	DNA polymerase lambda	Homo sapiens	176-184
25308545-3	2014	The performance of a combined SCGE/Pig-a gene mutation study was evaluated with the prototypical genotoxicant benzo[a]pyrene (BaP) at an exposure level known to induce germ cell mutation.	Benzo(a)pyrene	110-124	prohibitin 2	Mus musculus	126-129
25085976-7	2014	We show that specific overexpression of Ntf3 in neocortical neurons promotes an overproduction of BP at the expense of AP.	Benzo(a)pyrene	98-100	neurotrophin 3	Mus musculus	40-44
25228686-0	2014	Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.	Benzo(a)pyrene	105-119	RecQ like helicase	Homo sapiens	50-55
25228686-4	2014	The RECQ1-depleted cells exhibited increased replication protein A phosphorylation, Chk1 activation, and DNA double-strand breaks (DSBs) as compared to control or WRN-depleted cells following exposure to BaP treatment.	Benzo(a)pyrene	204-207	RecQ like helicase	Homo sapiens	4-9
25228686-2	2014	Here, we have evaluated a potential role of WRN (mutated in Werner syndrome) and RECQ1 (the most abundant homolog of WRN) in hydroquinone (HQ)- and benzo[a]pyrene (BaP)-induced genotoxicity.	Benzo(a)pyrene	164-167	WRN RecQ like helicase	Homo sapiens	44-47
25228686-2	2014	Here, we have evaluated a potential role of WRN (mutated in Werner syndrome) and RECQ1 (the most abundant homolog of WRN) in hydroquinone (HQ)- and benzo[a]pyrene (BaP)-induced genotoxicity.	Benzo(a)pyrene	164-167	RecQ like helicase	Homo sapiens	81-86
25228686-3	2014	Silencing of WRN or RECQ1 expression in HeLa cells increased their sensitivity to HQ and BaP but elicited distinct DNA damage response.	Benzo(a)pyrene	89-92	WRN RecQ like helicase	Homo sapiens	13-16
25228686-3	2014	Silencing of WRN or RECQ1 expression in HeLa cells increased their sensitivity to HQ and BaP but elicited distinct DNA damage response.	Benzo(a)pyrene	89-92	RecQ like helicase	Homo sapiens	20-25
25228686-5	2014	The BaP-induced DSBs in RECQ1-depleted cells were dependent on DNA-dependent protein kinase activity.	Benzo(a)pyrene	4-7	RecQ like helicase	Homo sapiens	24-29
25228686-6	2014	Notably, loss of WRN in RECQ1-depleted cells ameliorated BaP toxicity.	Benzo(a)pyrene	57-60	WRN RecQ like helicase	Homo sapiens	17-20
25228686-6	2014	Notably, loss of WRN in RECQ1-depleted cells ameliorated BaP toxicity.	Benzo(a)pyrene	57-60	RecQ like helicase	Homo sapiens	24-29
25228686-7	2014	Collectively, our results provide first indication of nonredundant participation of WRN and RECQ1 in protection from the potentially carcinogenic effects of BaP and HQ.	Benzo(a)pyrene	157-160	WRN RecQ like helicase	Homo sapiens	84-87
25228686-7	2014	Collectively, our results provide first indication of nonredundant participation of WRN and RECQ1 in protection from the potentially carcinogenic effects of BaP and HQ.	Benzo(a)pyrene	157-160	RecQ like helicase	Homo sapiens	92-97
24954032-0	2014	PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a.	Benzo(a)pyrene	42-56	tumor protein p53	Homo sapiens	65-68
24910982-6	2014	ATF2 was also identified as a sensitive stress responsive protein with activation observed at extract concentrations equivalent to 0.1 nM BP.	Benzo(a)pyrene	138-140	activating transcription factor 2	Homo sapiens	0-4
24954032-0	2014	PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a.	Benzo(a)pyrene	42-56	forkhead box O3	Homo sapiens	82-88
24954032-4	2014	We show that all three compounds amplified the accumulation of nuclear p53, elicited by benzo[a]pyrene (BaP) or dibenzo[al]pyrene (DBP).	Benzo(a)pyrene	88-102	tumor protein p53	Homo sapiens	71-74
24954032-4	2014	We show that all three compounds amplified the accumulation of nuclear p53, elicited by benzo[a]pyrene (BaP) or dibenzo[al]pyrene (DBP).	Benzo(a)pyrene	104-107	tumor protein p53	Homo sapiens	71-74
24954032-7	2014	We found that inhibition of PP2A phosphatase restored levels of phosphorylated FoxO3a, led to cytosolic translocation of p53, and activated BaP-induced p53-mediated apoptosis.	Benzo(a)pyrene	140-143	protein phosphatase 2 phosphatase activator	Homo sapiens	28-32
24954032-7	2014	We found that inhibition of PP2A phosphatase restored levels of phosphorylated FoxO3a, led to cytosolic translocation of p53, and activated BaP-induced p53-mediated apoptosis.	Benzo(a)pyrene	140-143	tumor protein p53	Homo sapiens	152-155
24954032-8	2014	These results were confirmed by silencing FoxO3a with siRNA or by inhibiting 14-3-3 protein; also these treatments trapped BaP-induced p53 in the nucleus.	Benzo(a)pyrene	123-126	forkhead box O3	Homo sapiens	42-48
24954032-8	2014	These results were confirmed by silencing FoxO3a with siRNA or by inhibiting 14-3-3 protein; also these treatments trapped BaP-induced p53 in the nucleus.	Benzo(a)pyrene	123-126	tumor protein p53	Homo sapiens	135-138
24954032-9	2014	Our data indicate interplay between p53, FoxO3a and 14-3-3 leading to an attenuated BaP induced apoptosis in cells co-exposed to TCDD, PCB 153 or estradiol.	Benzo(a)pyrene	84-87	tumor protein p53	Homo sapiens	36-39
24954032-9	2014	Our data indicate interplay between p53, FoxO3a and 14-3-3 leading to an attenuated BaP induced apoptosis in cells co-exposed to TCDD, PCB 153 or estradiol.	Benzo(a)pyrene	84-87	forkhead box O3	Homo sapiens	41-58
24922095-5	2014	ANP, BNP and c-Myc were also induced in the heart of adult zebrafish by BaP.	Benzo(a)pyrene	72-75	basonuclin 2	Danio rerio	5-8
24875912-7	2014	In addition, BaP exposure decreased the cellular density of the ganglion cell layer (GCL) significantly.	Benzo(a)pyrene	13-16	germ cell-less, spermatogenesis associated	Danio rerio	85-88
24685774-1	2014	Benzo[a]pyrene (BaP) is a known carcinogenic and cell damaging agent.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
24922095-5	2014	ANP, BNP and c-Myc were also induced in the heart of adult zebrafish by BaP.	Benzo(a)pyrene	72-75	MYC proto-oncogene, bHLH transcription factor a	Danio rerio	13-18
24922095-8	2014	Therefore, the mechanism of the cardiac hypertrophy caused by BaP exposure during early life stages may be through inducing the expression of CdC42, RhoA and Rac1, together with activating ERK1, 2.	Benzo(a)pyrene	62-65	cell division cycle 42	Danio rerio	142-147
24922095-8	2014	Therefore, the mechanism of the cardiac hypertrophy caused by BaP exposure during early life stages may be through inducing the expression of CdC42, RhoA and Rac1, together with activating ERK1, 2.	Benzo(a)pyrene	62-65	ras homolog gene family, member Ab	Danio rerio	149-153
24922095-8	2014	Therefore, the mechanism of the cardiac hypertrophy caused by BaP exposure during early life stages may be through inducing the expression of CdC42, RhoA and Rac1, together with activating ERK1, 2.	Benzo(a)pyrene	62-65	Rac family small GTPase 1a	Danio rerio	158-162
24922095-8	2014	Therefore, the mechanism of the cardiac hypertrophy caused by BaP exposure during early life stages may be through inducing the expression of CdC42, RhoA and Rac1, together with activating ERK1, 2.	Benzo(a)pyrene	62-65	mitogen-activated protein kinase 3	Danio rerio	189-196
24784728-5	2014	However, using electrophoretic mobility shift assays, we have found that XPC-RAD23B binding affinities of certain bulky lesions derived from metabolically activated polycyclic aromatic hydrocarbon compounds such as benzo[a]pyrene and dibenzo[a,l]pyrene, are not directly, or necessarily correlated with NER excision activities observed in cell-free extracts.	Benzo(a)pyrene	215-229	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	73-76
25032692-2	2014	In the present study, we have used a human physiologically-based pharmacokinetic (PBPK) model and an simple compartmental toxicokinetic model of benzo(a)pyrene (BaP) kinetics and its 3-hydroxybenzo(a)pyrene (3-OHBaP) metabolite to reproduce the time-course of this biomarker of exposure in the urine of industrially exposed workers and in turn predict the most plausible exposure scenarios.	Benzo(a)pyrene	145-159	prohibitin 2	Homo sapiens	161-164
24769260-2	2014	Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplacental carcinogenic PAH.	Benzo(a)pyrene	0-14	phenylalanine hydroxylase	Homo sapiens	56-59
24784728-5	2014	However, using electrophoretic mobility shift assays, we have found that XPC-RAD23B binding affinities of certain bulky lesions derived from metabolically activated polycyclic aromatic hydrocarbon compounds such as benzo[a]pyrene and dibenzo[a,l]pyrene, are not directly, or necessarily correlated with NER excision activities observed in cell-free extracts.	Benzo(a)pyrene	215-229	RAD23 homolog B, nucleotide excision repair protein	Homo sapiens	77-83
24532440-3	2014	The compound benzo-a-pyrene (BaP), a copious and noxious compound present in coal tar, automobile exhaust fumes, cigarette smoke and charbroiled food, is metabolised by CYP1A1 and has been studied in great detail.	Benzo(a)pyrene	13-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	169-175
24532440-3	2014	The compound benzo-a-pyrene (BaP), a copious and noxious compound present in coal tar, automobile exhaust fumes, cigarette smoke and charbroiled food, is metabolised by CYP1A1 and has been studied in great detail.	Benzo(a)pyrene	29-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	169-175
24905716-8	2014	Ovariectomy had no significant effect in control animals, but significantly increased Ang II-induced maximal BP response in prenatally hypoxic animals and eliminated the difference of BP response between the two groups.	Benzo(a)pyrene	109-111	angiotensinogen	Rattus norvegicus	86-92
24695682-0	2014	CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
24695682-0	2014	CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72
24695682-1	2014	Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1).	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
24695682-1	2014	Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1).	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	97-103
24905716-9	2014	Estrogen replacement in ovariectomized animals significantly decreased the BP response to angiotensin II I only in control, but not in hypoxic animals.	Benzo(a)pyrene	75-77	angiotensinogen	Rattus norvegicus	90-104
24709349-7	2014	Although no influence of MS was seen on the achievement of LDL-c targets (&lt;70 mg/dL), the presence of high BP, high blood glucose and low HDL-c was related to poorer control of LDL-c.	Benzo(a)pyrene	110-112	component of oligomeric golgi complex 2	Homo sapiens	180-185
24736433-11	2014	Using p53 heterozygous mutant epithelial cells from patients with Li-Fraumeni syndrome, we show that monoallelic mutation of p53 was associated with elevated levels of CYP1A1 and CYP1B1 under both basal conditions and following treatment with benzo[a]pyrene.	Benzo(a)pyrene	243-257	tumor protein p53	Homo sapiens	125-128
24736433-11	2014	Using p53 heterozygous mutant epithelial cells from patients with Li-Fraumeni syndrome, we show that monoallelic mutation of p53 was associated with elevated levels of CYP1A1 and CYP1B1 under both basal conditions and following treatment with benzo[a]pyrene.	Benzo(a)pyrene	243-257	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	168-174
24736433-11	2014	Using p53 heterozygous mutant epithelial cells from patients with Li-Fraumeni syndrome, we show that monoallelic mutation of p53 was associated with elevated levels of CYP1A1 and CYP1B1 under both basal conditions and following treatment with benzo[a]pyrene.	Benzo(a)pyrene	243-257	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	179-185
24736433-12	2014	Treatment with CP-31398, a p53 rescue compound, suppressed benzo[a]pyrene-mediated induction of CYP1A1 and CYP1B1 and the formation of DNA adducts.	Benzo(a)pyrene	59-73	tumor protein p53	Homo sapiens	27-30
24736433-12	2014	Treatment with CP-31398, a p53 rescue compound, suppressed benzo[a]pyrene-mediated induction of CYP1A1 and CYP1B1 and the formation of DNA adducts.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
24736433-12	2014	Treatment with CP-31398, a p53 rescue compound, suppressed benzo[a]pyrene-mediated induction of CYP1A1 and CYP1B1 and the formation of DNA adducts.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	63-68
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	cyclin-dependent kinase inhibitor 1A	Danio rerio	70-76
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	deleted in azoospermia-like	Danio rerio	78-82
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	NAD(P)H dehydrogenase, quinone 1	Danio rerio	84-88
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	nfe2 like bZIP transcription factor 2a	Danio rerio	90-94
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	SRY-box transcription factor 3	Danio rerio	100-104
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	134-139
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	141-147
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	deleted in azoospermia-like	Danio rerio	149-153
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	glutathione S-transferase pi 1.2	Danio rerio	155-160
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	Danio rerio	162-166
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	NAD(P)H dehydrogenase, quinone 1	Danio rerio	168-172
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	phosphatase and tensin homolog B	Danio rerio	174-178
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	tumor protein p53	Danio rerio	180-183
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	SRY-box transcription factor 2	Danio rerio	185-189
24576477-9	2014	CG methylation changed by 10% or more due to BaP in six genes (c-fos, cdkn1a, dazl, nqo1, nrf2, and sox3) at 3.3hpf and in ten genes (c-fos, cyp1b1, dazl, gstp1, mlh1, nqo1, pten, p53, sox2, and sox3) at 96hpf.	Benzo(a)pyrene	45-48	SRY-box transcription factor 3	Danio rerio	195-199
24576477-10	2014	BaP also induced gene expression of cyp1b1 and gstp1 at 96hpf which were found to be hypermethylated.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	36-42
24576477-10	2014	BaP also induced gene expression of cyp1b1 and gstp1 at 96hpf which were found to be hypermethylated.	Benzo(a)pyrene	0-3	glutathione S-transferase pi 1.2	Danio rerio	47-52
25190163-11	2014	The inconsistency between serum bilirubin and ALT levels was an important factor that suggested poor prognosis of ALF, and it might increase survival rate to use BP therapy before that inconsistency emerged.	Benzo(a)pyrene	162-164	afamin	Homo sapiens	114-117
24667232-10	2014	Besides transcriptional induction of ahr2 and cyp1a, BaP produced a significant induction of Ugt1a, Ugt5a1, Ugt5a3 and Ugt5a5 as well as a down-regulation of Ugt1b.	Benzo(a)pyrene	53-56	UDP glucuronosyltransferase 5 family, polypeptide A1	Danio rerio	100-106
25174381-18	2014	Compared with those detected before treatment, the levels of TNF-alpha, IL-6, and IL-8 in serum of group BP at PTH 24 and 48 were significantly decreased (with P values below 0.01).	Benzo(a)pyrene	105-107	tumor necrosis factor	Homo sapiens	61-70
25174381-18	2014	Compared with those detected before treatment, the levels of TNF-alpha, IL-6, and IL-8 in serum of group BP at PTH 24 and 48 were significantly decreased (with P values below 0.01).	Benzo(a)pyrene	105-107	interleukin 6	Homo sapiens	72-76
25174381-18	2014	Compared with those detected before treatment, the levels of TNF-alpha, IL-6, and IL-8 in serum of group BP at PTH 24 and 48 were significantly decreased (with P values below 0.01).	Benzo(a)pyrene	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
24727239-7	2014	It was shown that miR-21, 221, 222, and 429 expression levels decreased in the liver of DDT-, BP-, and MC-treated rats, whereas increases were observed in CYP1A1 and CYP2B1 mRNA expression levels and protein content, and EROD and PROD activities.	Benzo(a)pyrene	94-96	microRNA 21	Rattus norvegicus	18-24
24667232-10	2014	Besides transcriptional induction of ahr2 and cyp1a, BaP produced a significant induction of Ugt1a, Ugt5a1, Ugt5a3 and Ugt5a5 as well as a down-regulation of Ugt1b.	Benzo(a)pyrene	53-56	aryl hydrocarbon receptor 2	Danio rerio	37-41
24329544-3	2014	Some TK inhibitors cause BP elevation, by inhibiting the VEGF receptor 2 (VEGFR2).	Benzo(a)pyrene	25-27	kinase insert domain receptor	Rattus norvegicus	57-72
24329544-3	2014	Some TK inhibitors cause BP elevation, by inhibiting the VEGF receptor 2 (VEGFR2).	Benzo(a)pyrene	25-27	kinase insert domain receptor	Rattus norvegicus	74-80
24329544-15	2014	CONCLUSIONS AND IMPLICATIONS: Increased vascular resistance, secondary to reduced VEGF-induced NO release from endothelium, may contribute to BP increases observed with fostamatanib.	Benzo(a)pyrene	142-144	vascular endothelial growth factor A	Rattus norvegicus	82-86
22865514-0	2014	Downregulation of nuclear respiratory factor-1 contributes to mitochondrial events induced by benzo(a)pyrene.	Benzo(a)pyrene	94-108	nuclear respiratory factor 1	Homo sapiens	18-46
22865514-3	2014	However, the role of NRF-1 in BaP-induced mitochondrial event is not clear.	Benzo(a)pyrene	30-33	nuclear respiratory factor 1	Homo sapiens	21-26
22865514-4	2014	We investigated the change of NRF-1 and mtTFA in human bronchial epithelial cells (16HBE) elicited by BaP.	Benzo(a)pyrene	102-105	nuclear respiratory factor 1	Homo sapiens	30-35
22865514-4	2014	We investigated the change of NRF-1 and mtTFA in human bronchial epithelial cells (16HBE) elicited by BaP.	Benzo(a)pyrene	102-105	transcription factor A, mitochondrial	Homo sapiens	40-45
22865514-6	2014	The transcription and protein levels of NRF-1 and mtTFA decreased at 48 h after 16 muM BaP treatment.	Benzo(a)pyrene	87-90	nuclear respiratory factor 1	Homo sapiens	40-45
22865514-6	2014	The transcription and protein levels of NRF-1 and mtTFA decreased at 48 h after 16 muM BaP treatment.	Benzo(a)pyrene	87-90	transcription factor A, mitochondrial	Homo sapiens	50-55
22865514-7	2014	Our results indicated downregulation of NRF-1 and mtTFA is involved in BaP-induced mitochondrial events.	Benzo(a)pyrene	71-74	nuclear respiratory factor 1	Homo sapiens	40-45
22865514-7	2014	Our results indicated downregulation of NRF-1 and mtTFA is involved in BaP-induced mitochondrial events.	Benzo(a)pyrene	71-74	transcription factor A, mitochondrial	Homo sapiens	50-55
24477577-12	2014	The BaP metabolites identified were the following: BaP-9,10-diol; BaP-4,5-diol; BaP-7,8-diol; 9(OH) BaP; 3(OH) BaP; BaP-3,6-dione; and BaP-6,12-dione.	Benzo(a)pyrene	4-7	BAI1-associated protein 3	Mus musculus	116-121
24667232-10	2014	Besides transcriptional induction of ahr2 and cyp1a, BaP produced a significant induction of Ugt1a, Ugt5a1, Ugt5a3 and Ugt5a5 as well as a down-regulation of Ugt1b.	Benzo(a)pyrene	53-56	UDP glucuronosyltransferase 5 family, polypeptide A3	Danio rerio	108-114
24667232-10	2014	Besides transcriptional induction of ahr2 and cyp1a, BaP produced a significant induction of Ugt1a, Ugt5a1, Ugt5a3 and Ugt5a5 as well as a down-regulation of Ugt1b.	Benzo(a)pyrene	53-56	UDP glucuronosyltransferase 5 family, polypeptide A5	Danio rerio	119-125
24530354-3	2014	In microsomes from BaP-pretreated mice, in which Cyp1a1 was induced, higher levels of BaP metabolites were formed, mainly of BaP-7,8-dihydrodiol.	Benzo(a)pyrene	19-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
24530354-3	2014	In microsomes from BaP-pretreated mice, in which Cyp1a1 was induced, higher levels of BaP metabolites were formed, mainly of BaP-7,8-dihydrodiol.	Benzo(a)pyrene	86-89	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
24530354-6	2014	Two BaP-DNA adducts were formed in the presence of mEH, but only one when CYP1A1 and POR were present alone.	Benzo(a)pyrene	4-7	epoxide hydrolase 1, microsomal	Mus musculus	51-54
24530354-6	2014	Two BaP-DNA adducts were formed in the presence of mEH, but only one when CYP1A1 and POR were present alone.	Benzo(a)pyrene	4-7	cytochrome p450 oxidoreductase	Mus musculus	85-88
24497629-4	2014	Benzo[a]pyrene (BaP) treatment induced oxidative stress, mitochondrial respiratory defects, and mtDNA damage that was attenuated by a CYP1B1-specific inhibitor, 2,3,4,5-tetramethoxystilbene.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	134-140
24530354-7	2014	At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP.	Benzo(a)pyrene	88-91	cytochrome p450 oxidoreductase	Mus musculus	14-17
24530354-7	2014	At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP.	Benzo(a)pyrene	88-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	18-24
24530354-7	2014	At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP.	Benzo(a)pyrene	88-91	cytochrome b5 type A (microsomal)	Mus musculus	48-61
24530354-7	2014	At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP.	Benzo(a)pyrene	88-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	72-78
24530354-7	2014	At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP.	Benzo(a)pyrene	88-91	cytochrome b5 type A (microsomal)	Mus musculus	145-158
24530354-7	2014	At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP.	Benzo(a)pyrene	88-91	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	72-78
24530354-9	2014	Our results suggest that in livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of POR.	Benzo(a)pyrene	102-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	47-53
24530354-9	2014	Our results suggest that in livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of POR.	Benzo(a)pyrene	102-105	cytochrome b5 type A (microsomal)	Mus musculus	55-68
24530354-9	2014	Our results suggest that in livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of POR.	Benzo(a)pyrene	102-105	epoxide hydrolase 1, microsomal	Mus musculus	73-76
24497629-4	2014	Benzo[a]pyrene (BaP) treatment induced oxidative stress, mitochondrial respiratory defects, and mtDNA damage that was attenuated by a CYP1B1-specific inhibitor, 2,3,4,5-tetramethoxystilbene.	Benzo(a)pyrene	16-19	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	134-140
24497629-6	2014	Administration of benzo[a]pyrene or 2,3,7,8-tetrachlorodibenzodioxin induced similar mitochondrial functional abnormalities and oxidative stress in the lungs of wild-type mice and Cyp1a1/1a2-null mice, but the effects were markedly blunted in Cyp1b1-null mice.	Benzo(a)pyrene	18-32	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	180-186
24497629-6	2014	Administration of benzo[a]pyrene or 2,3,7,8-tetrachlorodibenzodioxin induced similar mitochondrial functional abnormalities and oxidative stress in the lungs of wild-type mice and Cyp1a1/1a2-null mice, but the effects were markedly blunted in Cyp1b1-null mice.	Benzo(a)pyrene	18-32	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	243-249
24705375-5	2014	Also, a significant increase in the protein expression of phosphorylated p53[ser15] confirmed p53 hyper-phosphorylation in BP treated mice.	Benzo(a)pyrene	123-125	transformation related protein 53, pseudogene	Mus musculus	73-76
24705375-5	2014	Also, a significant increase in the protein expression of phosphorylated p53[ser15] confirmed p53 hyper-phosphorylation in BP treated mice.	Benzo(a)pyrene	123-125	transformation related protein 53, pseudogene	Mus musculus	94-97
24705375-6	2014	On the other hand, enzyme activities of caspase 3 and caspase 9 were noticed to be significantly decreased following BP treatment.	Benzo(a)pyrene	117-119	caspase 3	Mus musculus	40-49
24705375-6	2014	On the other hand, enzyme activities of caspase 3 and caspase 9 were noticed to be significantly decreased following BP treatment.	Benzo(a)pyrene	117-119	caspase 9	Mus musculus	54-63
24705375-9	2014	Interestingly, combined treatment of curcumin and resveratrol to BP treated animals resulted in a significant decrease in p53 hyper-phosphorylation, 14C glucose uptakes/turnover and 3H-thymidine uptake in the BP treated mice.	Benzo(a)pyrene	65-67	transformation related protein 53, pseudogene	Mus musculus	122-125
24824713-1	2014	We evaluated association of BP stress-reactivity on the model of cardiac defense response in 45-70-year-old men with variable number of tandem repeat polymorphism in genes encoding dopamine transporter protein (DAT1) and serotonin transporter protein (5-HTTLPR).	Benzo(a)pyrene	28-30	solute carrier family 6 member 3	Homo sapiens	181-201
24077181-1	2014	BACKGROUND: CPAP is considered the therapy of choice for OSA, but the extent to which it can reduce BP is still under debate.	Benzo(a)pyrene	100-102	centromere protein J	Homo sapiens	12-16
24077181-2	2014	We undertook a systematic review and meta-analysis of randomized controlled trials (RCTs) to quantify the effect size of the reduction of BP by CPAP therapy compared with other passive (sham CPAP, tablets of placebo drug, conservative measures) or active (oral appliance, antihypertensive drugs) treatments.	Benzo(a)pyrene	138-140	centromere protein J	Homo sapiens	144-148
24824713-2	2014	It was found that individuals carrying long allele variant (l) of DAT1 gene (l/l: allele l homozygotes) in the genotype in comparison with short variant (s) carriers (heterozygous genotype l/s) demonstrate hyperreactive profiles of cardiovascular stress reactivity characterized by a significant increase in the amplitude and duration of long-latency BP components in cardiac defensive response.	Benzo(a)pyrene	351-353	solute carrier family 6 member 3	Homo sapiens	66-70
24077181-9	2014	CONCLUSIONS: Therapy with CPAP significantly reduces BP in patients with OSA but with a low effect size.	Benzo(a)pyrene	53-55	centromere protein J	Homo sapiens	26-30
24588654-0	2014	Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation.	Benzo(a)pyrene	23-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	46-52
24588654-0	2014	Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation.	Benzo(a)pyrene	23-37	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
24588654-7	2014	L-NAC or knock-down of Nrf2 significantly attenuated the inhibitory effects of Z-Ligustilide on BaP-induced CYP1A1 upregulation in NHEKs.	Benzo(a)pyrene	96-99	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
24588654-7	2014	L-NAC or knock-down of Nrf2 significantly attenuated the inhibitory effects of Z-Ligustilide on BaP-induced CYP1A1 upregulation in NHEKs.	Benzo(a)pyrene	96-99	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	108-114
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	12-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-141
24588654-8	2014	Taken together, these findings suggest that Z-Ligustilide can suppress BaP-induced CYP1A1 upregulation through ROS-dependent Nrf2 pathway activation and may be beneficial in preventing or treating BaP-induced skin damage.	Benzo(a)pyrene	71-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	12-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
24588654-8	2014	Taken together, these findings suggest that Z-Ligustilide can suppress BaP-induced CYP1A1 upregulation through ROS-dependent Nrf2 pathway activation and may be beneficial in preventing or treating BaP-induced skin damage.	Benzo(a)pyrene	71-74	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	12-26	aryl hydrocarbon receptor	Homo sapiens	168-193
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	12-26	aryl hydrocarbon receptor	Homo sapiens	195-198
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-141
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	28-31	aryl hydrocarbon receptor	Homo sapiens	168-193
24588654-1	2014	UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation.	Benzo(a)pyrene	28-31	aryl hydrocarbon receptor	Homo sapiens	195-198
24588654-2	2014	Here, we investigated the effect of Z-Ligustilide, an active ingredient isolated from the medicinal plants Cnidium officinale and Angelica acutiloba, on BaP-induced CYP1A1 upregulation in normal human epidermal keratinocytes (NHEKs) as well as its underlying mechanisms.	Benzo(a)pyrene	153-156	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	165-171
24588654-3	2014	Z-Ligustilide significantly inhibited BaP-induced CYP1A1 upregulation in NHEKs.	Benzo(a)pyrene	38-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
24262797-10	2014	Our data show that renal Nox5 is upregulated in human diabetic nephropathy and may alter filtration barrier function and systolic BP through the production of reactive oxygen species.	Benzo(a)pyrene	130-132	NADPH oxidase 5	Homo sapiens	25-29
24372170-2	2014	However, while in eukaryotes, the cytochrome P450 (CYP)-mediated activation of benzo[a]pyrene (B[a]P) has become a model for metabolism-mediated carcinogenesis, the oxidative degradation of B[a]P by microorganisms is less well studied.	Benzo(a)pyrene	79-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-49
24372170-2	2014	However, while in eukaryotes, the cytochrome P450 (CYP)-mediated activation of benzo[a]pyrene (B[a]P) has become a model for metabolism-mediated carcinogenesis, the oxidative degradation of B[a]P by microorganisms is less well studied.	Benzo(a)pyrene	79-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	51-54
23994691-6	2014	This was discovered by correlation between the depurinating adducts formed in mouse skin by treatment with benzo[a]pyrene, dibenzo[a,l]pyrene or 7,12-dimethylbenz[a]anthracene and the site of mutations in the Harvey-ras oncogene in mouse skin papillomas initiated by one of these PAH.	Benzo(a)pyrene	107-121	Harvey rat sarcoma virus oncogene	Mus musculus	209-219
24664296-6	2014	While CYP1A1 and 1B1 were induced by BaP, these inductions were not significantly reduced by curcumin or VE.	Benzo(a)pyrene	37-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-20
24584819-0	2014	Subchronic oral administration of Benzo[a]pyrene impairs motor and cognitive behavior and modulates S100B levels and MAPKs in rats.	Benzo(a)pyrene	34-48	S100 calcium binding protein B	Rattus norvegicus	100-105
24584819-9	2014	BaP induced a decrease on ERK2 phosphorylation in the hippocampus.	Benzo(a)pyrene	0-3	mitogen activated protein kinase 1	Rattus norvegicus	26-30
24584819-10	2014	Thus, BaP subchronic treatment induces an astroglial response and impairs both motor and cognitive behavior, with parallel inhibition of ERK2, a signaling enzyme involved in the hippocampal neuroplasticity.	Benzo(a)pyrene	6-9	mitogen activated protein kinase 1	Rattus norvegicus	137-141
24431215-7	2014	Both BaP and BPDE at the submicromolar concentrations (0.25 and 0.5 muM) dose-dependently repressed HSMPCs myogenic differentiation without obvious cell toxicity.	Benzo(a)pyrene	5-8	latexin	Homo sapiens	68-71
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	Benzo(a)pyrene	5-8	myogenin	Homo sapiens	69-77
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	Benzo(a)pyrene	5-8	AKT serine/threonine kinase 1	Homo sapiens	125-128
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	Benzo(a)pyrene	5-8	aryl hydrocarbon receptor	Homo sapiens	224-249
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	Benzo(a)pyrene	5-8	aryl hydrocarbon receptor	Homo sapiens	251-254
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	Benzo(a)pyrene	5-8	nuclear factor kappa B subunit 1	Homo sapiens	285-311
24431215-9	2014	BaP- and BPDE-activated NF-kappaB-p65 protein phosphorylation could also be attenuated by both AhR and ER inhibitors.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	95-98
24431215-11	2014	These results suggest that both BaP and BPDE are capable of inhibiting myogenesis via an AhR- or/and ER-regulated NF-kappaB/Akt signaling pathway.	Benzo(a)pyrene	32-35	aryl hydrocarbon receptor	Homo sapiens	89-92
24431215-11	2014	These results suggest that both BaP and BPDE are capable of inhibiting myogenesis via an AhR- or/and ER-regulated NF-kappaB/Akt signaling pathway.	Benzo(a)pyrene	32-35	AKT serine/threonine kinase 1	Homo sapiens	124-127
24664296-7	2014	Moreover, the level of activated p53 and PARP-1 were significantly induced by BaP, whereas this induction was markedly reduced after curcumin and VE co-treatment.	Benzo(a)pyrene	78-81	tumor protein p53	Homo sapiens	33-36
24664296-7	2014	Moreover, the level of activated p53 and PARP-1 were significantly induced by BaP, whereas this induction was markedly reduced after curcumin and VE co-treatment.	Benzo(a)pyrene	78-81	poly(ADP-ribose) polymerase 1	Homo sapiens	41-47
24664296-9	2014	The ratio of Bax/Bcl-2 was also significantly increased in cells exposed to BaP and this increase was reversed by VE co-treatment.	Benzo(a)pyrene	76-79	BCL2 associated X, apoptosis regulator	Homo sapiens	13-16
24664296-9	2014	The ratio of Bax/Bcl-2 was also significantly increased in cells exposed to BaP and this increase was reversed by VE co-treatment.	Benzo(a)pyrene	76-79	BCL2 apoptosis regulator	Homo sapiens	17-22
24664296-10	2014	Taken together, BaP-induced cytotoxicity occurs through DNA damage, cell cycle arrest, ROS production, modulation of metabolizing enzymes, and the expression/activation of p53, PARP-1, survivin, and Bax/Bcl-2.	Benzo(a)pyrene	16-19	tumor protein p53	Homo sapiens	172-175
24664296-10	2014	Taken together, BaP-induced cytotoxicity occurs through DNA damage, cell cycle arrest, ROS production, modulation of metabolizing enzymes, and the expression/activation of p53, PARP-1, survivin, and Bax/Bcl-2.	Benzo(a)pyrene	16-19	poly(ADP-ribose) polymerase 1	Homo sapiens	177-183
24664296-10	2014	Taken together, BaP-induced cytotoxicity occurs through DNA damage, cell cycle arrest, ROS production, modulation of metabolizing enzymes, and the expression/activation of p53, PARP-1, survivin, and Bax/Bcl-2.	Benzo(a)pyrene	16-19	BCL2 associated X, apoptosis regulator	Homo sapiens	199-202
24664296-10	2014	Taken together, BaP-induced cytotoxicity occurs through DNA damage, cell cycle arrest, ROS production, modulation of metabolizing enzymes, and the expression/activation of p53, PARP-1, survivin, and Bax/Bcl-2.	Benzo(a)pyrene	16-19	BCL2 apoptosis regulator	Homo sapiens	203-208
24688533-7	2013	The 12 samples in the most impacted area confirmed that BP was highest when ammonia was higher than 2 muM, also reporting the highest concentrations of chlorophyll a and suspended particles.	Benzo(a)pyrene	56-58	latexin	Homo sapiens	102-105
24361490-6	2014	BaP-mediated beta-hCG and syncytin-2 up-regulation was prevented by co-treatment by the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or by knocking-down AhR expression through siRNA transfection.	Benzo(a)pyrene	0-3	endogenous retrovirus group FRD member 1, envelope	Homo sapiens	26-36
24361490-6	2014	BaP-mediated beta-hCG and syncytin-2 up-regulation was prevented by co-treatment by the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or by knocking-down AhR expression through siRNA transfection.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	88-113
24361490-6	2014	BaP-mediated beta-hCG and syncytin-2 up-regulation was prevented by co-treatment by the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or by knocking-down AhR expression through siRNA transfection.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	115-118
24361490-6	2014	BaP-mediated beta-hCG and syncytin-2 up-regulation was prevented by co-treatment by the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or by knocking-down AhR expression through siRNA transfection.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	161-164
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	58-61	tumor protein p53	Homo sapiens	19-22
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	58-61	tumor protein p53	Homo sapiens	118-121
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	58-61	tumor protein p53	Homo sapiens	118-121
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	58-61	endogenous retrovirus group FRD member 1, envelope	Homo sapiens	224-234
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	246-249	tumor protein p53	Homo sapiens	19-22
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	246-249	tumor protein p53	Homo sapiens	118-121
24361490-8	2014	Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP.	Benzo(a)pyrene	246-249	tumor protein p53	Homo sapiens	118-121
24361490-9	2014	Taken together, these data demonstrate that BaP induces differentiation of placental trophoblastic BeWo cells in an AhR- and p53-dependent manner.	Benzo(a)pyrene	44-47	aryl hydrocarbon receptor	Homo sapiens	116-119
24361490-9	2014	Taken together, these data demonstrate that BaP induces differentiation of placental trophoblastic BeWo cells in an AhR- and p53-dependent manner.	Benzo(a)pyrene	44-47	tumor protein p53	Homo sapiens	125-128
24362009-0	2014	Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene.	Benzo(a)pyrene	136-150	tumor protein p53	Homo sapiens	35-38
24362009-0	2014	Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene.	Benzo(a)pyrene	136-150	microRNA 34c	Homo sapiens	39-46
24362009-2	2014	In this investigation, we evaluated changes in p53 function and its downstream target miRNAs in benzo[a]pyrene (BaP)-induced transformation of human bronchial epithelial (HBE) cells.	Benzo(a)pyrene	96-110	tumor protein p53	Homo sapiens	47-50
24362009-2	2014	In this investigation, we evaluated changes in p53 function and its downstream target miRNAs in benzo[a]pyrene (BaP)-induced transformation of human bronchial epithelial (HBE) cells.	Benzo(a)pyrene	112-115	tumor protein p53	Homo sapiens	47-50
24362009-3	2014	Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53).	Benzo(a)pyrene	20-23	tumor protein p53	Homo sapiens	114-117
24362009-3	2014	Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53).	Benzo(a)pyrene	20-23	tumor protein p53	Homo sapiens	122-125
24362009-3	2014	Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53).	Benzo(a)pyrene	20-23	tumor protein p53	Homo sapiens	122-125
24362009-3	2014	Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53).	Benzo(a)pyrene	20-23	tumor protein p53	Homo sapiens	122-125
24362009-3	2014	Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53).	Benzo(a)pyrene	20-23	tumor protein p53	Homo sapiens	122-125
24362009-3	2014	Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53).	Benzo(a)pyrene	20-23	tumor protein p53	Homo sapiens	122-125
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	29-32	tumor protein p53	Homo sapiens	36-39
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	29-32	tumor protein p53	Homo sapiens	117-120
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	29-32	tumor protein p53	Homo sapiens	117-120
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	29-32	tumor protein p53	Homo sapiens	117-120
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	148-151	tumor protein p53	Homo sapiens	117-120
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	148-151	tumor protein p53	Homo sapiens	117-120
24362009-4	2014	With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change.	Benzo(a)pyrene	148-151	tumor protein p53	Homo sapiens	117-120
24362009-7	2014	Over-expression of miR-34c resulted in inhibition of the BaP-induced G1-to-S transition and diminished up-regulation of cyclin D. Further, up-regulation of miR-34c or silencing of cylin D prevented BaP-induced malignant transformation.	Benzo(a)pyrene	57-60	microRNA 34c	Homo sapiens	19-26
24362009-7	2014	Over-expression of miR-34c resulted in inhibition of the BaP-induced G1-to-S transition and diminished up-regulation of cyclin D. Further, up-regulation of miR-34c or silencing of cylin D prevented BaP-induced malignant transformation.	Benzo(a)pyrene	198-201	microRNA 34c	Homo sapiens	19-26
24362009-7	2014	Over-expression of miR-34c resulted in inhibition of the BaP-induced G1-to-S transition and diminished up-regulation of cyclin D. Further, up-regulation of miR-34c or silencing of cylin D prevented BaP-induced malignant transformation.	Benzo(a)pyrene	198-201	microRNA 34c	Homo sapiens	156-163
24362009-8	2014	Thus, changes in the cell cycle mediated by the p53/miR-34c axis are involved in the transformation cells induced by BaP.	Benzo(a)pyrene	117-120	tumor protein p53	Homo sapiens	48-51
24362009-8	2014	Thus, changes in the cell cycle mediated by the p53/miR-34c axis are involved in the transformation cells induced by BaP.	Benzo(a)pyrene	117-120	microRNA 34c	Homo sapiens	52-59
23979991-10	2014	In addition, cells overexpressing HspA1A showed an increased CK2 activity after BaP treatment compared with control cells (p &lt; 0.01).	Benzo(a)pyrene	80-83	heat shock protein family A (Hsp70) member 1A	Homo sapiens	34-40
23979991-11	2014	Our results suggest that HspA1A facilitates DNA repair after BaP treatment.	Benzo(a)pyrene	61-64	heat shock protein family A (Hsp70) member 1A	Homo sapiens	25-31
24331032-6	2014	Total PAH concentration ranged between 0.3 and 8.29ngm(-3) and Benzo(a)pyrene (BaP) from 0.05 to 0.88ngm(-3).	Benzo(a)pyrene	63-77	prohibitin 2	Homo sapiens	79-82
24461735-0	2014	In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa.	Benzo(a)pyrene	103-117	DNA polymerase kappa	Homo sapiens	139-159
23979991-0	2014	HspA1A facilitates DNA repair in human bronchial epithelial cells exposed to Benzo[a]pyrene and interacts with casein kinase 2.	Benzo(a)pyrene	77-91	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-6
23839155-6	2014	Further analysis showed that B[a]P-induced apoptosis was accompanied by loss of mitochondrial membrane potential, release of cytochrome c from mitochondria to the cytosol, downregulation of antiapoptotic protein B-cell lymphoma-2 (Bcl-2) levels with concurrent upregulation in proapoptotic Bcl-2-associated X protein (Bax) levels, and increase in the levels and activities of caspases-9 and -3.	Benzo(a)pyrene	29-34	BCL2, apoptosis regulator	Rattus norvegicus	212-229
23839155-6	2014	Further analysis showed that B[a]P-induced apoptosis was accompanied by loss of mitochondrial membrane potential, release of cytochrome c from mitochondria to the cytosol, downregulation of antiapoptotic protein B-cell lymphoma-2 (Bcl-2) levels with concurrent upregulation in proapoptotic Bcl-2-associated X protein (Bax) levels, and increase in the levels and activities of caspases-9 and -3.	Benzo(a)pyrene	29-34	BCL2, apoptosis regulator	Rattus norvegicus	231-236
23839155-6	2014	Further analysis showed that B[a]P-induced apoptosis was accompanied by loss of mitochondrial membrane potential, release of cytochrome c from mitochondria to the cytosol, downregulation of antiapoptotic protein B-cell lymphoma-2 (Bcl-2) levels with concurrent upregulation in proapoptotic Bcl-2-associated X protein (Bax) levels, and increase in the levels and activities of caspases-9 and -3.	Benzo(a)pyrene	29-34	BCL2 associated X, apoptosis regulator	Rattus norvegicus	290-316
23839155-6	2014	Further analysis showed that B[a]P-induced apoptosis was accompanied by loss of mitochondrial membrane potential, release of cytochrome c from mitochondria to the cytosol, downregulation of antiapoptotic protein B-cell lymphoma-2 (Bcl-2) levels with concurrent upregulation in proapoptotic Bcl-2-associated X protein (Bax) levels, and increase in the levels and activities of caspases-9 and -3.	Benzo(a)pyrene	29-34	BCL2 associated X, apoptosis regulator	Rattus norvegicus	318-321
23839155-6	2014	Further analysis showed that B[a]P-induced apoptosis was accompanied by loss of mitochondrial membrane potential, release of cytochrome c from mitochondria to the cytosol, downregulation of antiapoptotic protein B-cell lymphoma-2 (Bcl-2) levels with concurrent upregulation in proapoptotic Bcl-2-associated X protein (Bax) levels, and increase in the levels and activities of caspases-9 and -3.	Benzo(a)pyrene	29-34	caspase 9	Rattus norvegicus	376-393
24418153-9	2014	Our study showed that SOX9 is expressed in centroacinar and ductal epithelial cells of BP and is a useful marker for pancreatic ductal lineage of pancreatic neoplasms.	Benzo(a)pyrene	87-89	SRY-box transcription factor 9	Homo sapiens	22-26
24586676-8	2014	In non-neoplastic situation, when zebrafish was exposed to PAH Benzo(a)pyrene, molecular silencing of gstt1 enhanced the proliferation of normal lymphocytes and upregulated myca expression.	Benzo(a)pyrene	63-77	glutathione S-transferase theta 1a	Danio rerio	102-107
24868967-0	2014	[Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo [a] pyrene].	Benzo(a)pyrene	75-91	tumor protein p53	Homo sapiens	10-13
24868967-0	2014	[Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo [a] pyrene].	Benzo(a)pyrene	75-91	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-39
24868967-1	2014	OBJECTIVE: To investigate the roles of p53 in the interaction of p21, cyclin D1 and CDK4 in human embryonic lung fibroblasts (HELFs) induced by benzo (a) pyrene.	Benzo(a)pyrene	144-160	tumor protein p53	Homo sapiens	39-42
24868967-1	2014	OBJECTIVE: To investigate the roles of p53 in the interaction of p21, cyclin D1 and CDK4 in human embryonic lung fibroblasts (HELFs) induced by benzo (a) pyrene.	Benzo(a)pyrene	144-160	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-68
24868967-1	2014	OBJECTIVE: To investigate the roles of p53 in the interaction of p21, cyclin D1 and CDK4 in human embryonic lung fibroblasts (HELFs) induced by benzo (a) pyrene.	Benzo(a)pyrene	144-160	cyclin D1	Homo sapiens	70-79
24868967-1	2014	OBJECTIVE: To investigate the roles of p53 in the interaction of p21, cyclin D1 and CDK4 in human embryonic lung fibroblasts (HELFs) induced by benzo (a) pyrene.	Benzo(a)pyrene	144-160	cyclin dependent kinase 4	Homo sapiens	84-88
24394547-0	2014	Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.	Benzo(a)pyrene	56-70	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	19-38
24394547-0	2014	Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.	Benzo(a)pyrene	56-70	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	40-46
24394547-2	2014	Cytochrome P450 1A1 (CYP1A1) plays a role in both metabolic activation and detoxication of BaP in a context-dependent manner.	Benzo(a)pyrene	91-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-19
24394547-2	2014	Cytochrome P450 1A1 (CYP1A1) plays a role in both metabolic activation and detoxication of BaP in a context-dependent manner.	Benzo(a)pyrene	91-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-27
24394547-4	2014	First, we fed Apoe-/- mice an atherogenic diet plus BaP and found that oral BaP-enhanced atherosclerosis is associated with increased reactive oxygen species (ROS) and inflammatory markers, such as plasma tumor necrosis factor levels and aortic mRNA expression of vascular endothelial growth factor A (Vegfa).	Benzo(a)pyrene	76-79	apolipoprotein E	Mus musculus	14-18
24394547-4	2014	First, we fed Apoe-/- mice an atherogenic diet plus BaP and found that oral BaP-enhanced atherosclerosis is associated with increased reactive oxygen species (ROS) and inflammatory markers, such as plasma tumor necrosis factor levels and aortic mRNA expression of vascular endothelial growth factor A (Vegfa).	Benzo(a)pyrene	76-79	vascular endothelial growth factor A	Mus musculus	264-300
24394547-4	2014	First, we fed Apoe-/- mice an atherogenic diet plus BaP and found that oral BaP-enhanced atherosclerosis is associated with increased reactive oxygen species (ROS) and inflammatory markers, such as plasma tumor necrosis factor levels and aortic mRNA expression of vascular endothelial growth factor A (Vegfa).	Benzo(a)pyrene	76-79	vascular endothelial growth factor A	Mus musculus	302-307
24394547-7	2014	The atherogenic diet plus BaP effectively elevated plasma ROS levels and expression of atherosclerosis-related genes, specifically Vegfa, in Cyp1a1-/- mice compared with wild-type mice.	Benzo(a)pyrene	26-29	vascular endothelial growth factor A	Mus musculus	131-136
24394547-7	2014	The atherogenic diet plus BaP effectively elevated plasma ROS levels and expression of atherosclerosis-related genes, specifically Vegfa, in Cyp1a1-/- mice compared with wild-type mice.	Benzo(a)pyrene	26-29	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	141-147
24394547-8	2014	BaP treatment increased Vegfa mRNA levels in mouse embryonic fibroblasts from Cyp1a1-/- mice but not from wild-type mice.	Benzo(a)pyrene	0-3	vascular endothelial growth factor A	Mus musculus	24-29
24394547-8	2014	BaP treatment increased Vegfa mRNA levels in mouse embryonic fibroblasts from Cyp1a1-/- mice but not from wild-type mice.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	78-84
24394547-9	2014	BaP-induced DNA adduct formation was increased in the aorta of Cyp1a1-/- mice, but not wild-type or Apoe-/- mice, and the atherogenic diet decreased BaP-induced DNA adducts in Cyp1a1-/- mice compared with mice on a control diet.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	63-69
24394547-9	2014	BaP-induced DNA adduct formation was increased in the aorta of Cyp1a1-/- mice, but not wild-type or Apoe-/- mice, and the atherogenic diet decreased BaP-induced DNA adducts in Cyp1a1-/- mice compared with mice on a control diet.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	176-182
24394547-9	2014	BaP-induced DNA adduct formation was increased in the aorta of Cyp1a1-/- mice, but not wild-type or Apoe-/- mice, and the atherogenic diet decreased BaP-induced DNA adducts in Cyp1a1-/- mice compared with mice on a control diet.	Benzo(a)pyrene	149-152	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	176-182
24394547-10	2014	These data suggest that ROS production contributes to BaP-exacerbated atherosclerosis and that CYP1A1 plays a protective role against oral BaP toxicity in aorta.	Benzo(a)pyrene	139-142	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	95-101
23703818-2	2014	Benzo(a)pyrene (BaP) is a toxicant that is released into the environment from automobile exhausts, cigarette smoke, burning of refuse, industrial emissions, and hazardous waste sites.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
24239969-8	2014	Further, in vitro work confirmed that B[a]P induced apoptosis was significantly suppressed in Ac-DEVD-CMK pre-treated cells.	Benzo(a)pyrene	38-43	C-X-C motif chemokine ligand 9	Homo sapiens	102-105
23676189-0	2014	Exploration of the mechanisms by which 3,4-benzopyrene promotes angiotensin II-induced abdominal aortic aneurysm formation in mice.	Benzo(a)pyrene	39-54	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	64-78
23676189-13	2014	CONCLUSIONS: BaP promotes Ang II-induced AAA formation in mice via elevating infiltration of macrophages, activating nuclear factor-kappaB, upregulating the expression of MMP-2, MMP-9, and MMP-12, and increasing the apoptosis of vascular muscle cells in its synergistic effect with Ang II in aortic wall.	Benzo(a)pyrene	13-16	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	26-32
23676189-13	2014	CONCLUSIONS: BaP promotes Ang II-induced AAA formation in mice via elevating infiltration of macrophages, activating nuclear factor-kappaB, upregulating the expression of MMP-2, MMP-9, and MMP-12, and increasing the apoptosis of vascular muscle cells in its synergistic effect with Ang II in aortic wall.	Benzo(a)pyrene	13-16	matrix metallopeptidase 2	Mus musculus	171-176
23676189-13	2014	CONCLUSIONS: BaP promotes Ang II-induced AAA formation in mice via elevating infiltration of macrophages, activating nuclear factor-kappaB, upregulating the expression of MMP-2, MMP-9, and MMP-12, and increasing the apoptosis of vascular muscle cells in its synergistic effect with Ang II in aortic wall.	Benzo(a)pyrene	13-16	matrix metallopeptidase 9	Mus musculus	178-183
23676189-13	2014	CONCLUSIONS: BaP promotes Ang II-induced AAA formation in mice via elevating infiltration of macrophages, activating nuclear factor-kappaB, upregulating the expression of MMP-2, MMP-9, and MMP-12, and increasing the apoptosis of vascular muscle cells in its synergistic effect with Ang II in aortic wall.	Benzo(a)pyrene	13-16	matrix metallopeptidase 12	Mus musculus	189-195
23676189-13	2014	CONCLUSIONS: BaP promotes Ang II-induced AAA formation in mice via elevating infiltration of macrophages, activating nuclear factor-kappaB, upregulating the expression of MMP-2, MMP-9, and MMP-12, and increasing the apoptosis of vascular muscle cells in its synergistic effect with Ang II in aortic wall.	Benzo(a)pyrene	13-16	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	282-288
24136241-6	2014	Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I.	Benzo(a)pyrene	118-120	5-hydroxytryptamine receptor 2A	Homo sapiens	30-35
24136241-6	2014	Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I.	Benzo(a)pyrene	118-120	tryptophan hydroxylase 2	Homo sapiens	40-44
24246761-0	2014	Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway.	Benzo(a)pyrene	40-54	solute carrier family 9 member A1	Homo sapiens	122-126
24246761-2	2014	We previously showed that the PAH prototype, benzo[a]pyrene (B[a]P), triggers apoptosis via DNA damage-induced p53 activation (genotoxic pathway) and via remodeling of the membrane cholesterol-rich microdomains called lipid rafts, leading to changes in pH homeostasis (non-genotoxic pathway).	Benzo(a)pyrene	45-59	tumor protein p53	Homo sapiens	111-114
24246761-8	2014	EPA and DHA prevented B[a]P-induced apoptotic alkalinization by affecting Na(+)/H(+) exchanger 1 activity.	Benzo(a)pyrene	22-27	solute carrier family 9 member A1	Homo sapiens	74-96
24412381-7	2014	Gene expression analyses from mouse tissues showed significantly decreased expression of ATM and Xrcc6 in BaP-treated liver and lung.	Benzo(a)pyrene	106-109	ataxia telangiectasia mutated	Mus musculus	89-92
24412381-7	2014	Gene expression analyses from mouse tissues showed significantly decreased expression of ATM and Xrcc6 in BaP-treated liver and lung.	Benzo(a)pyrene	106-109	X-ray repair complementing defective repair in Chinese hamster cells 6	Mus musculus	97-102
24412381-8	2014	In addition, BaP exposure significantly reduced the expression of Xrcc5, p53, and DNA-PKcs in lung.	Benzo(a)pyrene	13-16	X-ray repair complementing defective repair in Chinese hamster cells 5	Mus musculus	66-71
24412381-8	2014	In addition, BaP exposure significantly reduced the expression of Xrcc5, p53, and DNA-PKcs in lung.	Benzo(a)pyrene	13-16	transformation related protein 53, pseudogene	Mus musculus	73-76
24412381-8	2014	In addition, BaP exposure significantly reduced the expression of Xrcc5, p53, and DNA-PKcs in lung.	Benzo(a)pyrene	13-16	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	82-90
23676189-1	2014	OBJECTIVE: This study examined the influence of 3,4-benzopyrene (BaP), a compound found in cigarette smoke, on the formation of angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) formation in mice and the underlying mechanisms.	Benzo(a)pyrene	48-63	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	128-142
23676189-1	2014	OBJECTIVE: This study examined the influence of 3,4-benzopyrene (BaP), a compound found in cigarette smoke, on the formation of angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) formation in mice and the underlying mechanisms.	Benzo(a)pyrene	48-63	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	144-150
23676189-1	2014	OBJECTIVE: This study examined the influence of 3,4-benzopyrene (BaP), a compound found in cigarette smoke, on the formation of angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) formation in mice and the underlying mechanisms.	Benzo(a)pyrene	65-68	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	128-142
23676189-1	2014	OBJECTIVE: This study examined the influence of 3,4-benzopyrene (BaP), a compound found in cigarette smoke, on the formation of angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) formation in mice and the underlying mechanisms.	Benzo(a)pyrene	65-68	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	144-150
23676189-9	2014	RESULTS: The Ang II infusion and BaP injection induced AAAs in 41.67% of mice vs 25% in the Ang II group (P &lt; .05).	Benzo(a)pyrene	33-36	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	92-98
25146616-14	2014	According to progression of CML, HO-1 expression level in CML patients increased from CP (0.009 5+-0.017 6) to AP (0.028 0+-0.055 7) and then to BP (0.276 7 +- 0.447 0).	Benzo(a)pyrene	145-147	heme oxygenase 1	Homo sapiens	33-37
25658124-1	2014	CYP1B1, a recently described dioxin inducible oxidoreductase, is a member of the cytochrome P450 superfamily involved in the metabolism of estradiol, retinol, benzo[a]pyrene, tamoxifen, melatonin, sterols etc.	Benzo(a)pyrene	159-173	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
25134396-9	2014	RESULTS: The serum soluble CD200 level was observed to be statistically significantly higher in patients with BP (77.6 +/- 15.7 pg/mL) compared with healthy controls (26.1 +/- 6.7 pg/mL), (p &lt; 0.001).	Benzo(a)pyrene	110-112	CD200 molecule	Homo sapiens	27-32
24048010-2	2014	It, more specifically a lower ratio of Benzo[a]pyrene to Coronone (BaP/COR), is suggested as a marker for vehicle emission.	Benzo(a)pyrene	39-53	prohibitin 2	Homo sapiens	67-70
23842862-1	2014	A microcosm experiment was conducted to investigate the dissipation of available benzo[a]pyrene (BaP) in soils co-contaminated with cadmium (Cd) and pyrene (PYR) during aging process.	Benzo(a)pyrene	81-95	prohibitin 2	Homo sapiens	97-100
24827591-1	2014	Based on the high solubility efficiency and strong fluorescence response of benzo(a)pyrene (BaP) in dimethyl sulfoxide in combination with the high-performance derivative constant-energy synchronous fluorescence spectroscopic (DCESFS) technique, a simple, sensitive and economic method was developed for the determination of BaP in liquid milk.	Benzo(a)pyrene	76-90	prohibitin 2	Homo sapiens	92-95
24827591-1	2014	Based on the high solubility efficiency and strong fluorescence response of benzo(a)pyrene (BaP) in dimethyl sulfoxide in combination with the high-performance derivative constant-energy synchronous fluorescence spectroscopic (DCESFS) technique, a simple, sensitive and economic method was developed for the determination of BaP in liquid milk.	Benzo(a)pyrene	76-90	prohibitin 2	Homo sapiens	325-328
24148789-7	2014	They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.	Benzo(a)pyrene	74-76	cAMP responsive element binding protein 1	Homo sapiens	35-39
25374376-1	2014	The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse.	Benzo(a)pyrene	124-138	prohibitin 2	Mus musculus	140-143
25102744-14	2014	Replacing the previous therapy different ACE inhibitors, sartans and calcium antagonists to the fixed combination amlodipine and lisinopril) (drug EKVATOR), leads to a rapid, pronounced, and safe reduction of BP and improve health in the majority of patients with previously uncorrected BP.	Benzo(a)pyrene	209-211	angiotensin I converting enzyme	Homo sapiens	41-44
25102744-14	2014	Replacing the previous therapy different ACE inhibitors, sartans and calcium antagonists to the fixed combination amlodipine and lisinopril) (drug EKVATOR), leads to a rapid, pronounced, and safe reduction of BP and improve health in the majority of patients with previously uncorrected BP.	Benzo(a)pyrene	287-289	angiotensin I converting enzyme	Homo sapiens	41-44
25638374-0	2014	Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.	Benzo(a)pyrene	62-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-39
25638374-0	2014	Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.	Benzo(a)pyrene	62-76	cytochrome b5 type A	Homo sapiens	121-134
25638374-1	2014	OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	186-189	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-37
25638374-1	2014	OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	186-189	epoxide hydrolase 1	Homo sapiens	212-240
25638374-1	2014	OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	186-189	epoxide hydrolase 1, microsomal	Mus musculus	242-245
25638374-2	2014	However, it is still not clearly explained how the electron transfer is mediated by NADPH:CYP oxidoreductase (POR), another component of the microsomal enzymatic system, on CYP1A1 during BaP oxidation, and whether microsomal cytochrome b5 might influence this electron transfer.	Benzo(a)pyrene	187-190	cytochrome p450 oxidoreductase	Homo sapiens	110-113
25638374-2	2014	However, it is still not clearly explained how the electron transfer is mediated by NADPH:CYP oxidoreductase (POR), another component of the microsomal enzymatic system, on CYP1A1 during BaP oxidation, and whether microsomal cytochrome b5 might influence this electron transfer.	Benzo(a)pyrene	187-190	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	173-179
25638374-3	2014	METHODS: High performance liquid chromatography (HPLC) was employed for separation of BaP metabolites formed by enzymatic systems containing human CYP1A1.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	147-153
25638374-4	2014	RESULTS: Human CYP1A1 expressed with POR in eukaryotic and prokaryotic expression cellular systems, in microsomes of insect cells (Supersomes) and in a membrane fraction of Escherichia coli, respectively, and these enzyme systems reconstituted with purified cytochrome b5 were utilized to study BaP oxidation.	Benzo(a)pyrene	295-298	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	15-21
25638374-5	2014	Human CYP1A1 expressed in Supersomes oxidized BaP to seven metabolites [7,8- and 9,10-dihydrodiols, 1,6-dione, 3,6-dione, 3- and 9-phenols, and a metabolite with unknown structure (Mx)], whereas this enzyme expressed in membranes of E. coli formed only the metabolites 1,6- and 3,6-diones, 3- and 9-phenols, and Mx.	Benzo(a)pyrene	46-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-12
25638374-6	2014	Addition of cytochrome b5 to CYP1A1 expressed in the eukaryotic system led to a more than 2-fold increase in BaP metabolism, but had essentially no effect on BaP oxidation by CYP1A1 expressed in E. coli.	Benzo(a)pyrene	109-112	cytochrome b5 type A	Homo sapiens	12-25
25638374-6	2014	Addition of cytochrome b5 to CYP1A1 expressed in the eukaryotic system led to a more than 2-fold increase in BaP metabolism, but had essentially no effect on BaP oxidation by CYP1A1 expressed in E. coli.	Benzo(a)pyrene	109-112	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	29-35
25638374-7	2014	CONCLUSION: The effect of cytochrome b5 on CYP1A1 conformation and the electron transfer to this enzyme may contribute to the cytochrome b5-mediated stimulation of BaP oxidation.	Benzo(a)pyrene	164-167	cytochrome b5 type A	Homo sapiens	26-39
25638374-7	2014	CONCLUSION: The effect of cytochrome b5 on CYP1A1 conformation and the electron transfer to this enzyme may contribute to the cytochrome b5-mediated stimulation of BaP oxidation.	Benzo(a)pyrene	164-167	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
25638374-7	2014	CONCLUSION: The effect of cytochrome b5 on CYP1A1 conformation and the electron transfer to this enzyme may contribute to the cytochrome b5-mediated stimulation of BaP oxidation.	Benzo(a)pyrene	164-167	cytochrome b5 type A	Homo sapiens	126-139
25126521-0	2014	The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.	Benzo(a)pyrene	90-104	telomerase reverse transcriptase	Homo sapiens	10-14
25638381-8	2014	BNF, a known inducer of CYP1A1, showed a synergistic effect on BaP-mediated CYP1A1 induction and BaP activation in liver.	Benzo(a)pyrene	63-66	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	24-30
25638381-8	2014	BNF, a known inducer of CYP1A1, showed a synergistic effect on BaP-mediated CYP1A1 induction and BaP activation in liver.	Benzo(a)pyrene	63-66	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	76-82
25638381-8	2014	BNF, a known inducer of CYP1A1, showed a synergistic effect on BaP-mediated CYP1A1 induction and BaP activation in liver.	Benzo(a)pyrene	97-100	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	24-30
25126521-4	2014	Cells exhibited cytotoxicity to concentrations of B[a]P and Cd as low as 1 nm and 3 muM, respectively.	Benzo(a)pyrene	50-55	latexin	Homo sapiens	84-87
24025706-2	2013	Previously, we have observed that tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat lung epithelial RLE-6TN cells, a model of alveolar type II cells.	Benzo(a)pyrene	135-149	tumor necrosis factor	Rattus norvegicus	34-61
24025706-2	2013	Previously, we have observed that tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat lung epithelial RLE-6TN cells, a model of alveolar type II cells.	Benzo(a)pyrene	135-149	tumor necrosis factor	Rattus norvegicus	63-72
24061964-1	2013	Although both arsenic trioxide (As2O3) and benzo(a)pyrene (BaP) are well-established human carcinogens, the interaction between As2O3 and BaP is synergistic or antagonistic remains controversial in terms of the existing studies.	Benzo(a)pyrene	43-57	prohibitin 2	Homo sapiens	59-62
23591205-1	2013	Benzo(a)pyrene (BaP) is one of the most dangerous PAH due to its high carcinogenic and mutagenic character.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
23566666-1	2013	OBJECTIVES: To investigate the effects of benzo[a]pyrene (B[a]P), a major toxic component of cigarette smoke, on the expression of Slug and to determine the effect of B[a]P/Slug on the invasive properties of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS).	Benzo(a)pyrene	42-56	snail family transcriptional repressor 2	Homo sapiens	131-135
23703817-1	2013	Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
23703817-1	2013	Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	88-98
23703817-1	2013	Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	102-118
23703817-1	2013	Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	120-123
23996611-7	2013	Pretreatment with NA prevented the B[a]P-induced effect on NMDAR1 expression in both cell lines.	Benzo(a)pyrene	35-40	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	59-65
24107266-7	2013	Prenatal BaP exposure significantly increased visceral adipose tissue weight, weight gain between 3 weeks and 7.5 months of age, hepatic lipid content measured by oil red O staining, and hepatic fatty acid beta-oxidation gene expression in Gclm(+/+), but not in Gclm(-/-), female offspring.	Benzo(a)pyrene	9-12	glutamate-cysteine ligase, modifier subunit	Mus musculus	240-244
24107266-7	2013	Prenatal BaP exposure significantly increased visceral adipose tissue weight, weight gain between 3 weeks and 7.5 months of age, hepatic lipid content measured by oil red O staining, and hepatic fatty acid beta-oxidation gene expression in Gclm(+/+), but not in Gclm(-/-), female offspring.	Benzo(a)pyrene	9-12	glutamate-cysteine ligase, modifier subunit	Mus musculus	262-266
23598607-2	2013	However, the impact of the treatment of OSA with CPAP on BP in patients with resistant HTN is not well established.	Benzo(a)pyrene	57-59	centromere protein J	Homo sapiens	49-53
23598607-9	2013	CONCLUSIONS: The treatment of OSA with CPAP significantly reduces daytime BP in patients with resistant HTN.	Benzo(a)pyrene	74-76	centromere protein J	Homo sapiens	39-43
23929932-10	2013	CONCLUSIONS: Treatment with a RAS blocker, valsartan, is associated with an increase in soluble Klotho, which may contribute to the BP-independent cardiorenal benefits of these drugs in DKD.	Benzo(a)pyrene	132-134	klotho	Homo sapiens	96-102
21887816-6	2013	Pretreatment with cytochrome P450 inhibitor alpha-naphthoflavone or p53 inhibitor pifithrin-alpha inhibited the benzo-[a]-pyrene-induced p21 expression.	Benzo(a)pyrene	112-128	tumor protein p53	Homo sapiens	68-71
21887816-6	2013	Pretreatment with cytochrome P450 inhibitor alpha-naphthoflavone or p53 inhibitor pifithrin-alpha inhibited the benzo-[a]-pyrene-induced p21 expression.	Benzo(a)pyrene	112-128	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-140
24095716-1	2013	Benzo[a]pyrene (BaP) is a human carcinogen requiring metabolic activation prior to reaction with DNA.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
23453640-12	2013	Higher frequencies of the C:A haplotype and lower frequencies of the A:C haplotype at the GSK-3beta gene (rs1732170:rs11921360) were also found to be associated to SB in BP.	Benzo(a)pyrene	170-172	glycogen synthase kinase 3 beta	Homo sapiens	90-99
23453640-13	2013	Therefore, our results suggest that genetic variability at IMPA2, INPP1 and GSK3beta genes is associated with the emergence of SB in BP.	Benzo(a)pyrene	133-135	inositol monophosphatase 2	Homo sapiens	59-64
23453640-13	2013	Therefore, our results suggest that genetic variability at IMPA2, INPP1 and GSK3beta genes is associated with the emergence of SB in BP.	Benzo(a)pyrene	133-135	inositol polyphosphate-1-phosphatase	Homo sapiens	66-71
23453640-13	2013	Therefore, our results suggest that genetic variability at IMPA2, INPP1 and GSK3beta genes is associated with the emergence of SB in BP.	Benzo(a)pyrene	133-135	glycogen synthase kinase 3 beta	Homo sapiens	76-84
23996611-8	2013	However, although NA prevented the B[a]P-mediated increase in NMDAR2B expression in C6, it further potentiated the decrease of NMDAR2B in Neuro2a cells.	Benzo(a)pyrene	35-40	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	62-69
23956140-5	2013	Liver-S9 fractions obtained from PB/beta-NF- and BaP-treated rats significantly increased the number of revertants induced by niclosamide, while the CYP1A1 inhibitor alpha-NF decreased the number of revertants.	Benzo(a)pyrene	49-52	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	149-155
23982178-6	2013	In addition, Ahr is an attractive molecule because tobacco smoke is a well-known environmental risk factor for RA development and Ahr agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methyl cholanthrene, and benzo[a]pyrene, are major toxic components in cigarettes.	Benzo(a)pyrene	216-230	aryl hydrocarbon receptor	Homo sapiens	13-16
23845848-3	2013	Recently, it was shown that the PAH benzo[a]pyrene (BaP) can induce CYP3A4 as well.	Benzo(a)pyrene	52-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74
24195061-0	2013	Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene.	Benzo(a)pyrene	66-80	von Hippel-Lindau tumor suppressor	Homo sapiens	8-11
24195061-9	2013	Taken together, these data indicate that loss of VHL affects BaP-mediated genotoxic responses in RCC and decreases repair capacity.	Benzo(a)pyrene	61-64	von Hippel-Lindau tumor suppressor	Homo sapiens	49-52
23845848-6	2013	In the present study, a CYP3A4 reporter gene assay, requiring the overexpression of PXR, was used to investigate whether the PAH parent compounds BaP, benzo[c]phenanthrene (BcP) and dibenzo[a,l]pyrene (DBalP) as well as their corresponding phase I metabolites, the respective dihydrodiols and diol epoxides, can induce CYP3A4 promoter activity.	Benzo(a)pyrene	146-149	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-30
23845848-7	2013	BaP, BcP and their dihydrodiols were found to significantly activate the CYP3A4 promoter.	Benzo(a)pyrene	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-79
23892139-7	2013	Although no statistically significant differences were observed between case and control groups, methylation levels of probes mapping on three genes, ERCC8, LEPREL1 and SDC2, were strongly associated with cumulative BP exposure levels (p&lt;1.31E-007).	Benzo(a)pyrene	216-218	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	150-155
23892139-7	2013	Although no statistically significant differences were observed between case and control groups, methylation levels of probes mapping on three genes, ERCC8, LEPREL1 and SDC2, were strongly associated with cumulative BP exposure levels (p&lt;1.31E-007).	Benzo(a)pyrene	216-218	prolyl 3-hydroxylase 2	Homo sapiens	157-164
23892139-7	2013	Although no statistically significant differences were observed between case and control groups, methylation levels of probes mapping on three genes, ERCC8, LEPREL1 and SDC2, were strongly associated with cumulative BP exposure levels (p&lt;1.31E-007).	Benzo(a)pyrene	216-218	syndecan 2	Homo sapiens	169-173
23825067-9	2013	We conclude that relatively equipressor doses of ANG II and PE lead to greatly different ambient BP profiles and effects on the renal vasculature when assessed in conscious rats.	Benzo(a)pyrene	97-99	angiotensinogen	Rattus norvegicus	49-62
23889671-2	2013	Specifically, statins modulate BP through the up-regulation of endothelial NOS (eNOS) activation in the brain.	Benzo(a)pyrene	31-33	nitric oxide synthase 3	Rattus norvegicus	63-78
23889671-9	2013	Likewise, administration of Akt and ERK1/2 signalling inhibitors, LY294002 and PD98059, attenuated the reduction in BP evoked by simvastatin.	Benzo(a)pyrene	116-118	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
23889671-9	2013	Likewise, administration of Akt and ERK1/2 signalling inhibitors, LY294002 and PD98059, attenuated the reduction in BP evoked by simvastatin.	Benzo(a)pyrene	116-118	mitogen activated protein kinase 3	Rattus norvegicus	36-42
23929924-8	2013	CONCLUSIONS: Aldosterone breakthrough is a frequent event 1 year after initiating renin-angiotensin-aldosterone system blockade, particularly in participants exposed to intensive lowering of BP with sodium depletion and short-acting angiotensin II receptor blockers.	Benzo(a)pyrene	191-193	renin	Homo sapiens	82-87
23853263-7	2013	In a separate independent study, RNA samples from the livers of mice administered benzo(a)pyrene also demonstrated increased levels of Cdkn1a and the antisense lincRNA-p21 transcript.	Benzo(a)pyrene	82-96	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	135-141
23853263-7	2013	In a separate independent study, RNA samples from the livers of mice administered benzo(a)pyrene also demonstrated increased levels of Cdkn1a and the antisense lincRNA-p21 transcript.	Benzo(a)pyrene	82-96	tumor protein p53 pathway corepressor 1	Mus musculus	160-171
23800876-5	2013	Induction also required Nrf2, as induction by benzo[a]pyrene was lost in the liver of Nrf2 knockout mice similarly to induction by butyl hydroxyanisol, demonstrating a cross-interaction between the AhR and Nrf2 pathways for induction in vivo.	Benzo(a)pyrene	46-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
23800876-5	2013	Induction also required Nrf2, as induction by benzo[a]pyrene was lost in the liver of Nrf2 knockout mice similarly to induction by butyl hydroxyanisol, demonstrating a cross-interaction between the AhR and Nrf2 pathways for induction in vivo.	Benzo(a)pyrene	46-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
23800876-5	2013	Induction also required Nrf2, as induction by benzo[a]pyrene was lost in the liver of Nrf2 knockout mice similarly to induction by butyl hydroxyanisol, demonstrating a cross-interaction between the AhR and Nrf2 pathways for induction in vivo.	Benzo(a)pyrene	46-60	aryl-hydrocarbon receptor	Mus musculus	198-201
23800876-5	2013	Induction also required Nrf2, as induction by benzo[a]pyrene was lost in the liver of Nrf2 knockout mice similarly to induction by butyl hydroxyanisol, demonstrating a cross-interaction between the AhR and Nrf2 pathways for induction in vivo.	Benzo(a)pyrene	46-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
23633517-5	2013	In human bronchial epithelial cells (HBECs), RIP1 was significantly induced by cigarette smoke extract or benzo[a]pyrene diol epoxide (BPDE), the active form of the tobacco-specific carcinogen benzo(a)pyrene.	Benzo(a)pyrene	193-207	receptor interacting serine/threonine kinase 1	Homo sapiens	45-49
23834963-0	2013	P-glycoprotein and CYP1A protein expression patterns in Nile tilapia (Oreochromis niloticus) tissues after waterborne exposure to benzo(a)pyrene (BaP).	Benzo(a)pyrene	130-144	P-glycoprotein	Oreochromis niloticus	0-14
23834963-0	2013	P-glycoprotein and CYP1A protein expression patterns in Nile tilapia (Oreochromis niloticus) tissues after waterborne exposure to benzo(a)pyrene (BaP).	Benzo(a)pyrene	130-144	cytochrome P450 1A	Oreochromis niloticus	19-24
23834963-0	2013	P-glycoprotein and CYP1A protein expression patterns in Nile tilapia (Oreochromis niloticus) tissues after waterborne exposure to benzo(a)pyrene (BaP).	Benzo(a)pyrene	146-149	P-glycoprotein	Oreochromis niloticus	0-14
23834963-0	2013	P-glycoprotein and CYP1A protein expression patterns in Nile tilapia (Oreochromis niloticus) tissues after waterborne exposure to benzo(a)pyrene (BaP).	Benzo(a)pyrene	146-149	cytochrome P450 1A	Oreochromis niloticus	19-24
23834963-1	2013	The protein levels and tissue distribution patterns of P-glycoprotein (Pgp) and cytochrome P450 (CYP1A) were investigated in Nile tilapia (Oreochromis niloticus) after waterborne exposure to different benzo(a)pyrene (BaP) concentrations, using immunochemical approaches.	Benzo(a)pyrene	201-215	P-glycoprotein	Oreochromis niloticus	55-69
23834963-1	2013	The protein levels and tissue distribution patterns of P-glycoprotein (Pgp) and cytochrome P450 (CYP1A) were investigated in Nile tilapia (Oreochromis niloticus) after waterborne exposure to different benzo(a)pyrene (BaP) concentrations, using immunochemical approaches.	Benzo(a)pyrene	217-220	P-glycoprotein	Oreochromis niloticus	55-69
23834963-4	2013	CYP1A, detected with the mAb C10-7, reacted positively in liver, gills and intestine and followed a BaP dose-dependent fold induction.	Benzo(a)pyrene	100-103	cytochrome P450 1A	Oreochromis niloticus	0-5
23834963-5	2013	Taken together, these results indicate that CYP1A is involved in BaP metabolism in liver, gills and intestine, however, further studies are needed to elucidate the possible interaction of the efflux protein Pgp with BaP and/or its metabolites.	Benzo(a)pyrene	65-68	cytochrome P450 1A	Oreochromis niloticus	44-49
23834963-5	2013	Taken together, these results indicate that CYP1A is involved in BaP metabolism in liver, gills and intestine, however, further studies are needed to elucidate the possible interaction of the efflux protein Pgp with BaP and/or its metabolites.	Benzo(a)pyrene	65-68	P-glycoprotein	Oreochromis niloticus	207-210
23834963-5	2013	Taken together, these results indicate that CYP1A is involved in BaP metabolism in liver, gills and intestine, however, further studies are needed to elucidate the possible interaction of the efflux protein Pgp with BaP and/or its metabolites.	Benzo(a)pyrene	216-219	cytochrome P450 1A	Oreochromis niloticus	44-49
23834963-5	2013	Taken together, these results indicate that CYP1A is involved in BaP metabolism in liver, gills and intestine, however, further studies are needed to elucidate the possible interaction of the efflux protein Pgp with BaP and/or its metabolites.	Benzo(a)pyrene	216-219	P-glycoprotein	Oreochromis niloticus	207-210
23761301-0	2013	Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.	Benzo(a)pyrene	5-19	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	85-89
23761301-5	2013	Ten-fold lower oral BaP doses result in adenocarcinoma of the proximal small intestine (PSI) in Cyp1a1(-/-) mice; Cyp1a1/1b1(-/-) double-knockout mice show no PSI cancer but develop squamous cell carcinoma of the preputial gland duct (PGD).	Benzo(a)pyrene	20-23	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	96-102
23761301-6	2013	BaP-metabolizing CYP1B1 in the PSI and CYP3A59 in the PGD are the most likely candidates to participate in tumor initiation in the epithelial cells of these two tissues; oncogenes and tumor-suppressor genes upregulated and downregulated during tumorigenesis are completely different between these tissues.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	17-23
23761301-6	2013	BaP-metabolizing CYP1B1 in the PSI and CYP3A59 in the PGD are the most likely candidates to participate in tumor initiation in the epithelial cells of these two tissues; oncogenes and tumor-suppressor genes upregulated and downregulated during tumorigenesis are completely different between these tissues.	Benzo(a)pyrene	0-3	cytochrome P450, family 3, subfamily a, polypeptide 59	Mus musculus	39-46
23748015-11	2013	We also found that Ogg1(-/-)Myh(-/-) mice had a decreased lifespan after oral gavage with benzo[a]pyrene compared to wildtype mice and sham-exposed Ogg1(-/-)Myh(-/-) mice.	Benzo(a)pyrene	90-104	8-oxoguanine DNA-glycosylase 1	Mus musculus	19-23
23748015-11	2013	We also found that Ogg1(-/-)Myh(-/-) mice had a decreased lifespan after oral gavage with benzo[a]pyrene compared to wildtype mice and sham-exposed Ogg1(-/-)Myh(-/-) mice.	Benzo(a)pyrene	90-104	mutY DNA glycosylase	Mus musculus	28-31
24064117-1	2013	OBJECTIVE: The oxidation of benzo (a) pyrene mediated by 5-lipoxygenase (5-LOX) were investigated in HBE cells in order to provide further proof that lipoxygenase is the alternative pathway for the oxidation of xenobiotics.	Benzo(a)pyrene	28-44	arachidonate 5-lipoxygenase	Homo sapiens	57-71
24064117-1	2013	OBJECTIVE: The oxidation of benzo (a) pyrene mediated by 5-lipoxygenase (5-LOX) were investigated in HBE cells in order to provide further proof that lipoxygenase is the alternative pathway for the oxidation of xenobiotics.	Benzo(a)pyrene	28-44	arachidonate 5-lipoxygenase	Homo sapiens	73-78
24064117-10	2013	Flow cytometry and single cell gel electrophoresis experiments show, Benzo (a) pyrene can induce 5-lipoxygenase protein expression, but AA-861 cannot in HBE.	Benzo(a)pyrene	69-85	arachidonate 5-lipoxygenase	Homo sapiens	97-111
24064117-12	2013	CONCLUSIONS: The co-oxidate of benzo (a) pyrene by 5-LOX turns into electrophiles that covalently bind to DNA and induce DNA damage, which can be significantly inhibited by AA-861.	Benzo(a)pyrene	31-47	arachidonate 5-lipoxygenase	Homo sapiens	51-56
23977169-6	2013	The effects of SELENBP1 downregulation on the susceptibility of benzo(a)pyrene (B[a]P)-induced human bronchial epithelial cell transformation were determined.	Benzo(a)pyrene	64-78	selenium binding protein 1	Homo sapiens	15-23
23639521-0	2013	Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.	Benzo(a)pyrene	84-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-41
23955088-0	2013	Benzo-[a]-pyrene induces FAK activation and cell migration in MDA-MB-231 breast cancer cells.	Benzo(a)pyrene	0-16	protein tyrosine kinase 2	Homo sapiens	25-28
23955088-4	2013	Here, we demonstrate that B[a]P induces cell migration through a lipoxygenase- and Src-dependent pathway, as well as the activation of focal adhesion kinase, Src, and the extracellular signal-regulated kinase 2 in MDA-MB-231 breast cancer cells.	Benzo(a)pyrene	26-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-86
23955088-4	2013	Here, we demonstrate that B[a]P induces cell migration through a lipoxygenase- and Src-dependent pathway, as well as the activation of focal adhesion kinase, Src, and the extracellular signal-regulated kinase 2 in MDA-MB-231 breast cancer cells.	Benzo(a)pyrene	26-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	158-161
23955088-4	2013	Here, we demonstrate that B[a]P induces cell migration through a lipoxygenase- and Src-dependent pathway, as well as the activation of focal adhesion kinase, Src, and the extracellular signal-regulated kinase 2 in MDA-MB-231 breast cancer cells.	Benzo(a)pyrene	26-31	mitogen-activated protein kinase 3	Homo sapiens	171-210
23583300-0	2013	Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism.	Benzo(a)pyrene	0-14	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
23769370-9	2013	The proportion of BP in the cow"s diet was positively correlated with the concentrations of fatty acids with chain lengths greater than C18 and with UFA, MUFA, and PUFA.	Benzo(a)pyrene	18-20	MUFA	Bos taurus	154-158
23769370-9	2013	The proportion of BP in the cow"s diet was positively correlated with the concentrations of fatty acids with chain lengths greater than C18 and with UFA, MUFA, and PUFA.	Benzo(a)pyrene	18-20	PUFA	Bos taurus	164-168
23588036-4	2013	Employing positron emission tomography (PET), we hypothesized that beer"s flavor alone can reduce the binding potential (BP) of [(11)C]raclopride (RAC; a reflection of striatal DA release) in the ventral striatum, relative to an appetitive flavor control.	Benzo(a)pyrene	121-123	AKT serine/threonine kinase 1	Homo sapiens	147-150
23754852-5	2013	Structure-guided mutagenesis of Msl5 distinguished four essential amino acids that contact the BP sequence from nine other BP-binding residues that are inessential.	Benzo(a)pyrene	95-97	mRNA splicing protein MSL5	Saccharomyces cerevisiae S288C	32-36
23754852-5	2013	Structure-guided mutagenesis of Msl5 distinguished four essential amino acids that contact the BP sequence from nine other BP-binding residues that are inessential.	Benzo(a)pyrene	123-125	mRNA splicing protein MSL5	Saccharomyces cerevisiae S288C	32-36
23936120-6	2013	The specific mechanism mediating the effects of BP revealed that insulin-stimulated phosphorylation of Akt was strongly decreased, and its downstream substrate, phospho-GSK3beta, was downregulated by BPE treatment in 3T3-L1 cells.	Benzo(a)pyrene	48-50	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
23936120-7	2013	Together, these data indicated that BP exerted anti-adipogenic activity by inhibiting the expression of PPARgamma and C/EBPbeta and the Akt signaling pathway in 3T3-L1 adipocytes.	Benzo(a)pyrene	36-38	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	104-113
23936120-7	2013	Together, these data indicated that BP exerted anti-adipogenic activity by inhibiting the expression of PPARgamma and C/EBPbeta and the Akt signaling pathway in 3T3-L1 adipocytes.	Benzo(a)pyrene	36-38	CCAAT/enhancer binding protein beta	Rattus norvegicus	118-127
23936120-7	2013	Together, these data indicated that BP exerted anti-adipogenic activity by inhibiting the expression of PPARgamma and C/EBPbeta and the Akt signaling pathway in 3T3-L1 adipocytes.	Benzo(a)pyrene	36-38	AKT serine/threonine kinase 1	Rattus norvegicus	136-139
23936120-12	2013	Taken together, these results demonstrated an inhibitory effect of BP on adipogenesis through the down-regulation of C/EBPbeta, C/EBPalpha, and PPARgamma and the reduction of the phospho-Akt adipogenic factor in 3T3-L1 cells.	Benzo(a)pyrene	67-69	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	117-126
23936120-12	2013	Taken together, these results demonstrated an inhibitory effect of BP on adipogenesis through the down-regulation of C/EBPbeta, C/EBPalpha, and PPARgamma and the reduction of the phospho-Akt adipogenic factor in 3T3-L1 cells.	Benzo(a)pyrene	67-69	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	128-138
23936120-12	2013	Taken together, these results demonstrated an inhibitory effect of BP on adipogenesis through the down-regulation of C/EBPbeta, C/EBPalpha, and PPARgamma and the reduction of the phospho-Akt adipogenic factor in 3T3-L1 cells.	Benzo(a)pyrene	67-69	peroxisome proliferator activated receptor gamma	Mus musculus	144-153
23936120-12	2013	Taken together, these results demonstrated an inhibitory effect of BP on adipogenesis through the down-regulation of C/EBPbeta, C/EBPalpha, and PPARgamma and the reduction of the phospho-Akt adipogenic factor in 3T3-L1 cells.	Benzo(a)pyrene	67-69	AKT serine/threonine kinase 1	Rattus norvegicus	187-190
23652152-0	2013	Involvement of DNA polymerase beta overexpression in the malignant transformation induced by benzo[a]pyrene.	Benzo(a)pyrene	93-107	polymerase (DNA directed), beta	Mus musculus	15-34
23652152-1	2013	OBJECTIVE: To explore the relationship between DNA polymerase beta (pol beta) overexpression and benzo[a]pyrene (BaP) carcinogenesis.	Benzo(a)pyrene	97-111	polymerase (DNA directed), beta	Mus musculus	47-66
23652152-1	2013	OBJECTIVE: To explore the relationship between DNA polymerase beta (pol beta) overexpression and benzo[a]pyrene (BaP) carcinogenesis.	Benzo(a)pyrene	97-111	polymerase (DNA directed), beta	Mus musculus	68-76
23652152-1	2013	OBJECTIVE: To explore the relationship between DNA polymerase beta (pol beta) overexpression and benzo[a]pyrene (BaP) carcinogenesis.	Benzo(a)pyrene	113-116	polymerase (DNA directed), beta	Mus musculus	47-66
23652152-1	2013	OBJECTIVE: To explore the relationship between DNA polymerase beta (pol beta) overexpression and benzo[a]pyrene (BaP) carcinogenesis.	Benzo(a)pyrene	113-116	polymerase (DNA directed), beta	Mus musculus	68-76
23652152-2	2013	METHODS: Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase beta (pol beta cell) and high level of pol beta (pol beta oe cell) were treated by various concentrations of BaP to determine genetic instability induced by BaP under differential expression levels of pol beta.	Benzo(a)pyrene	202-205	polymerase (DNA directed), beta	Mus musculus	132-140
23652152-2	2013	METHODS: Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase beta (pol beta cell) and high level of pol beta (pol beta oe cell) were treated by various concentrations of BaP to determine genetic instability induced by BaP under differential expression levels of pol beta.	Benzo(a)pyrene	202-205	polymerase (DNA directed), beta	Mus musculus	132-140
23652152-2	2013	METHODS: Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase beta (pol beta cell) and high level of pol beta (pol beta oe cell) were treated by various concentrations of BaP to determine genetic instability induced by BaP under differential expression levels of pol beta.	Benzo(a)pyrene	202-205	polymerase (DNA directed), beta	Mus musculus	132-140
23652152-3	2013	Secondly, malignant transformation of pol beta cells by low concentration of BaP (20 muM) was determined by soft agar colony formation assay and transformation focus assay.	Benzo(a)pyrene	77-80	polymerase (DNA directed), beta	Mus musculus	38-46
23652152-5	2013	RESULTS: Pol beta cells were successfully transformed into malignant pol beta-T cells by an exposure to low concentration of BaP for 6 months.	Benzo(a)pyrene	125-128	polymerase (DNA directed), beta	Mus musculus	9-17
23652152-5	2013	RESULTS: Pol beta cells were successfully transformed into malignant pol beta-T cells by an exposure to low concentration of BaP for 6 months.	Benzo(a)pyrene	125-128	polymerase (DNA directed), beta	Mus musculus	69-77
23776235-2	2013	Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes.	Benzo(a)pyrene	36-50	aryl-hydrocarbon receptor	Mus musculus	122-147
23776235-2	2013	Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes.	Benzo(a)pyrene	36-50	aryl-hydrocarbon receptor	Mus musculus	149-152
23776235-2	2013	Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes.	Benzo(a)pyrene	36-50	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	242-246
23776235-2	2013	Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes.	Benzo(a)pyrene	52-55	aryl-hydrocarbon receptor	Mus musculus	122-147
23776235-2	2013	Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes.	Benzo(a)pyrene	52-55	aryl-hydrocarbon receptor	Mus musculus	149-152
23776235-2	2013	Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes.	Benzo(a)pyrene	52-55	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	242-246
23723425-2	2013	The insulin receptor in the distal tubule appears to modulate BP, but the role of the insulin receptor in the proximal tubule is unknown.	Benzo(a)pyrene	62-64	insulin receptor	Mus musculus	4-20
23712474-0	2013	Role of ubiquitin protein ligase Ring2 in DNA damage of human bronchial epithelial cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	100-114	ring finger protein 2	Homo sapiens	33-38
23712474-3	2013	In a series of experiments using the human bronchial epithelia cells (16HBE) and small interfering RNA (siRNA)-Ring2 cells exposed to benzo(a)pyrene (BaP), we measured dynamic changes in the levels of DNA damage, expressions of ubiquitinated histone H2A, and nucleotide excision repair (NER) subunit xeroderma pigmentosum (XP) groups A, C, and F (XPA, XPC, XPF).	Benzo(a)pyrene	134-148	ring finger protein 2	Homo sapiens	111-116
23712474-3	2013	In a series of experiments using the human bronchial epithelia cells (16HBE) and small interfering RNA (siRNA)-Ring2 cells exposed to benzo(a)pyrene (BaP), we measured dynamic changes in the levels of DNA damage, expressions of ubiquitinated histone H2A, and nucleotide excision repair (NER) subunit xeroderma pigmentosum (XP) groups A, C, and F (XPA, XPC, XPF).	Benzo(a)pyrene	150-153	ring finger protein 2	Homo sapiens	111-116
23712474-4	2013	We found that in vitro exposure to BaP increased DNA damage in a time- and dose-dependent manner in 16HBE and siRNA-Ring2 cells.	Benzo(a)pyrene	35-38	ring finger protein 2	Homo sapiens	116-121
23712474-5	2013	The results show that although decrease of Ring2 causes DNA hypersensitivity to BaP, the levels of XPA, XPC, and XPF were not affected.	Benzo(a)pyrene	80-83	ring finger protein 2	Homo sapiens	43-48
23583300-0	2013	Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism.	Benzo(a)pyrene	0-14	interleukin 2	Homo sapiens	142-146
26909280-9	2013	Previous reports have reported decreased VEGF levels in patients following BP treatment in vivo.	Benzo(a)pyrene	75-77	vascular endothelial growth factor A	Homo sapiens	41-45
23597728-5	2013	BaP-induced CYP1A mRNA levels were unaffected by hypoxia, suggesting that reduced bile BaP concentration may be related with effects on protein amount or enzyme activities.	Benzo(a)pyrene	0-3	cytochrome P450 1A	Oreochromis niloticus	12-17
23746685-8	2013	There was a continuous relationship between BP and renal risk, with a significative risk of pathological albuminuria (OR=7.75 [6.69-8.96]) and of low eGFR (OR: 1.33 [1.09-1.60]) in subjects with BP greater than or equal to 180/110 mmHg, compared to those with normal BP.	Benzo(a)pyrene	44-46	epidermal growth factor receptor	Homo sapiens	150-154
23803536-0	2013	[Role of ubiquitin ligase Ring2 in DNA damage induced by benzo[a]pyrene].	Benzo(a)pyrene	57-71	ring finger protein 2	Homo sapiens	26-31
23766534-8	2013	Thus, we conclude that the chloride/bicarbonate exchanger pendrin plays a major role in controlling net NaCl absorption, thereby influencing BP under conditions of high salt intake.	Benzo(a)pyrene	141-143	solute carrier family 26, member 4	Mus musculus	58-65
23629002-2	2013	Previously, for clinical application, we added aromatic benzene-pyridine (BP-type) analogs to the 3"-overhang region of the RNA-strand and changed the sequences of the passenger strand in the miR-143 duplex.	Benzo(a)pyrene	74-76	microRNA 143	Homo sapiens	192-199
23629002-3	2013	Here, we demonstrated the antitumor effect in vitro and in vivo of miR-205 that was also chemically modified by BP and had altered passenger sequence.	Benzo(a)pyrene	112-114	microRNA 205	Homo sapiens	67-74
23803536-1	2013	OBJECTIVE: To investigate the role of ubiquitin ligase Ring2 in the DNA damage induced by benzo[a]pyrene (B[a]P).	Benzo(a)pyrene	90-104	ring finger protein 2	Homo sapiens	55-60
23803536-1	2013	OBJECTIVE: To investigate the role of ubiquitin ligase Ring2 in the DNA damage induced by benzo[a]pyrene (B[a]P).	Benzo(a)pyrene	106-111	ring finger protein 2	Homo sapiens	55-60
23700472-8	2013	In addition, Tg(cyp1a:gfp) medaka fry also responded to two other AhR agonists, 3-methylcholanthrene and benzo[a]pyrene, for GFP induction, but no significant GFP induction was observed towards several other chemicals tested, indicating the specificity of this transgenic line.	Benzo(a)pyrene	105-119	cytochrome P450 1A1	Oryzias latipes	16-21
23583462-8	2013	RESULTS: Mice sensitized to BP exhibit chronic airway hyperresponsiveness (AHR), lung inflammation (documented by compliance and resistance measurements), eosinophil infiltrates in BAL, as well as Bet v 1-specific Th2 biased responses.	Benzo(a)pyrene	28-30	delta/notch-like EGF repeat containing	Mus musculus	197-200
23583462-8	2013	RESULTS: Mice sensitized to BP exhibit chronic airway hyperresponsiveness (AHR), lung inflammation (documented by compliance and resistance measurements), eosinophil infiltrates in BAL, as well as Bet v 1-specific Th2 biased responses.	Benzo(a)pyrene	28-30	heart and neural crest derivatives expressed 2	Mus musculus	214-217
23583462-9	2013	Both SLIT with soluble rBet v 1a (50mug/dose) and BP extract (equivalent to 50mug rBet v 1 per dose) lead to a significant reduction in AHR, lung eosinophilia and Th2 responses.	Benzo(a)pyrene	50-52	heart and neural crest derivatives expressed 2	Mus musculus	163-166
23700472-8	2013	In addition, Tg(cyp1a:gfp) medaka fry also responded to two other AhR agonists, 3-methylcholanthrene and benzo[a]pyrene, for GFP induction, but no significant GFP induction was observed towards several other chemicals tested, indicating the specificity of this transgenic line.	Benzo(a)pyrene	105-119	aryl hydrocarbon receptor 1b	Oryzias latipes	66-69
23508959-2	2013	CYP1A1 is particularly well known for its ability to biotransform polycyclic aromatic hydrocarbons, such as benzo[a]pyrene in tobacco smoke, into carcinogens.	Benzo(a)pyrene	108-122	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
23047765-0	2013	Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	23-29
23047765-1	2013	Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
23678290-3	2013	In the present study, we studied the mechanism of BP suppression of tumorigenesis induced by Aurora-A.	Benzo(a)pyrene	50-52	aurora kinase A	Homo sapiens	93-101
23678290-5	2013	When these isogenic cell lines are treated with BP for 48 h, accumulation of G2M phase and aneuploidy are commonly observed, and HCT116 p21(-) cells show increase in apoptosis.	Benzo(a)pyrene	48-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-139
23678290-6	2013	In xenograft assay, s.c. injection of BP efficiently inhibits tumorigenesis of HCT116 deficient for Chk2 or p21.	Benzo(a)pyrene	38-40	checkpoint kinase 2	Homo sapiens	100-104
23678290-6	2013	In xenograft assay, s.c. injection of BP efficiently inhibits tumorigenesis of HCT116 deficient for Chk2 or p21.	Benzo(a)pyrene	38-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	108-111
23678290-8	2013	Significantly, 5-FU (5-fluorouracil) treatment further induces apoptosis of BP-resistant HCT116 deficient for Chk2 or Puma.	Benzo(a)pyrene	76-78	checkpoint kinase 2	Homo sapiens	110-114
23678290-9	2013	These results demonstrate that p21 deficiency enhances BP-mediated suppression of tumor growth, and that BP and 5-FU can collaborate for tumor regression.	Benzo(a)pyrene	55-57	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-34
23626760-3	2013	Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction.	Benzo(a)pyrene	169-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	192-198
23626760-3	2013	Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction.	Benzo(a)pyrene	169-183	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	203-209
23626760-3	2013	Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction.	Benzo(a)pyrene	185-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	192-198
23626760-3	2013	Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction.	Benzo(a)pyrene	185-187	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	203-209
23626760-4	2013	We simultaneously assessed mRNA level, protein expression and enzymatic activity of the CYP1A enzymes, as well as mRNA and protein expressions of the aryl hydrocarbon receptor (AhR), which mediates the BP effect.	Benzo(a)pyrene	202-204	aryl hydrocarbon receptor	Rattus norvegicus	150-175
23626760-4	2013	We simultaneously assessed mRNA level, protein expression and enzymatic activity of the CYP1A enzymes, as well as mRNA and protein expressions of the aryl hydrocarbon receptor (AhR), which mediates the BP effect.	Benzo(a)pyrene	202-204	aryl hydrocarbon receptor	Rattus norvegicus	177-180
23370448-4	2013	It is noteworthy that BE (at 4.85mug/mL) and its main components, procyanidins (PCs) and cyanidin 3-glucoside (C3G), at 10muM significantly reduced the genotoxic effect induced by benzo[a]pyrene [B(a)P].	Benzo(a)pyrene	180-194	Rap guanine nucleotide exchange factor 1	Homo sapiens	89-114
23333640-0	2013	The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	Benzo(a)pyrene	105-119	endothelial PAS domain protein 1	Homo sapiens	18-28
23333640-0	2013	The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	Benzo(a)pyrene	105-119	ATM serine/threonine kinase	Homo sapiens	36-39
23333640-0	2013	The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	Benzo(a)pyrene	105-119	checkpoint kinase 2	Homo sapiens	40-45
23333640-1	2013	Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens.	Benzo(a)pyrene	18-32	prohibitin 2	Homo sapiens	34-37
23439269-0	2013	Association of aryl hydrocarbon receptor gene polymorphism with the neurobehavioral function and autonomic nervous system function changes induced by benzo[a]pyrene exposure in coke oven workers.	Benzo(a)pyrene	150-164	aryl hydrocarbon receptor	Homo sapiens	15-40
23439269-1	2013	OBJECTIVE: To analyze the association of aryl hydrocarbon receptor (AhR) gene polymorphism and the neurotoxicity induced by benzo[a]pyrene (B[a]P) in coke oven workers.	Benzo(a)pyrene	124-138	aryl hydrocarbon receptor	Homo sapiens	41-66
23439269-1	2013	OBJECTIVE: To analyze the association of aryl hydrocarbon receptor (AhR) gene polymorphism and the neurotoxicity induced by benzo[a]pyrene (B[a]P) in coke oven workers.	Benzo(a)pyrene	124-138	aryl hydrocarbon receptor	Homo sapiens	68-71
23325794-0	2013	Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo.	Benzo(a)pyrene	79-93	catalase	Homo sapiens	25-33
23325794-0	2013	Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo.	Benzo(a)pyrene	79-93	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	38-44
24331771-8	2013	In addition, BP group had improved serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels.	Benzo(a)pyrene	13-15	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	41-52
24331771-8	2013	In addition, BP group had improved serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels.	Benzo(a)pyrene	13-15	leptin	Rattus norvegicus	54-60
24331771-8	2013	In addition, BP group had improved serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels.	Benzo(a)pyrene	13-15	C-C motif chemokine ligand 2	Rattus norvegicus	65-99
24331771-8	2013	In addition, BP group had improved serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels.	Benzo(a)pyrene	13-15	C-C motif chemokine ligand 2	Rattus norvegicus	101-106
23318731-1	2013	Exposure of human oral mucosa to lead (Pb) and benzo[a]pyrene (BaP) by inhalation and ingestion can lead to pathological conditions via apoptosis and oxidative and nitrosative stress.	Benzo(a)pyrene	47-61	prohibitin 2	Homo sapiens	63-66
23745427-9	2013	Besides, Benzo [ a] pyrene equivalent toxicity analysis results show that the BEQs of B10 fuel decreased by 21.6% compared to pure diesel.	Benzo(a)pyrene	9-26	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	86-89
23228475-3	2013	Benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are toxic environmental pollutants and are prototypes of aryl hydrocarbon receptor (AHR) ligands.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	125-150
23228475-3	2013	Benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are toxic environmental pollutants and are prototypes of aryl hydrocarbon receptor (AHR) ligands.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	152-155
23228475-3	2013	Benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are toxic environmental pollutants and are prototypes of aryl hydrocarbon receptor (AHR) ligands.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	125-150
23228475-3	2013	Benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are toxic environmental pollutants and are prototypes of aryl hydrocarbon receptor (AHR) ligands.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	152-155
23036853-0	2013	Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.	Benzo(a)pyrene	18-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	84-103
23220466-5	2013	Persistent activation of checkpoint kinase 1 (Chk1) was observed at significantly lower BP equivalent concentrations in air PM extracts than BP alone.	Benzo(a)pyrene	88-90	checkpoint kinase 1	Homo sapiens	25-44
23220466-5	2013	Persistent activation of checkpoint kinase 1 (Chk1) was observed at significantly lower BP equivalent concentrations in air PM extracts than BP alone.	Benzo(a)pyrene	88-90	checkpoint kinase 1	Homo sapiens	46-50
23220466-5	2013	Persistent activation of checkpoint kinase 1 (Chk1) was observed at significantly lower BP equivalent concentrations in air PM extracts than BP alone.	Benzo(a)pyrene	141-143	checkpoint kinase 1	Homo sapiens	25-44
23220466-5	2013	Persistent activation of checkpoint kinase 1 (Chk1) was observed at significantly lower BP equivalent concentrations in air PM extracts than BP alone.	Benzo(a)pyrene	141-143	checkpoint kinase 1	Homo sapiens	46-50
23036853-10	2013	Further experiments using "Tet-On" cytochrome P450 1A1-overexpressing cells and a recombinant cytochrome P450 1A1 enzyme demonstrated that this is the key enzyme involved in the biotransformation of BaP, that is, both production and inactivation of BPDE.	Benzo(a)pyrene	199-202	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-113
23135907-4	2013	Therefore, we hypothesized that mice that are genetically deficient in GSH synthesis, due to deletion of the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have increased destruction of oogonia, premature ovarian failure, and ovarian tumorigenesis after transplacental BaP exposure compared with Gclm(+/+) females.	Benzo(a)pyrene	319-322	glutamate-cysteine ligase, modifier subunit	Mus musculus	156-160
23135907-6	2013	Compared with oil-treated F1 females of the same genotype, Gclm(-/-) prenatally BaP-treated females had significantly greater decrements in offspring production than Gclm(+/+) BaP-treated females.	Benzo(a)pyrene	80-83	glutamate-cysteine ligase, modifier subunit	Mus musculus	59-63
23135907-7	2013	Similarly, we observed significant BaP dose x Gclm genotype interactions on ovarian follicle counts and ovarian tumor multiplicity at 7.5 months of age, with Gclm(-/-) females having greater decrements in follicle numbers and more ovarian tumors in response to prenatal BaP exposure than Gclm(+/+) females.	Benzo(a)pyrene	35-38	glutamate-cysteine ligase, modifier subunit	Mus musculus	158-162
23135907-7	2013	Similarly, we observed significant BaP dose x Gclm genotype interactions on ovarian follicle counts and ovarian tumor multiplicity at 7.5 months of age, with Gclm(-/-) females having greater decrements in follicle numbers and more ovarian tumors in response to prenatal BaP exposure than Gclm(+/+) females.	Benzo(a)pyrene	35-38	glutamate-cysteine ligase, modifier subunit	Mus musculus	158-162
23135907-9	2013	Our results show that prenatal exposure of females to BaP causes premature ovarian failure and ovarian tumorigenesis and that embryonic GSH deficiency due to deletion of Gclm increases sensitivity to these transplacental ovarian effects of BaP.	Benzo(a)pyrene	240-243	glutamate-cysteine ligase, modifier subunit	Mus musculus	170-174
23036853-5	2013	Surprisingly, mutant frequency induced by BaP at the hypoxanthine-guanine phosphribosyltransferase (HPRT) locus was decreased by pretreatment with TCDD.	Benzo(a)pyrene	42-45	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	53-98
23036853-5	2013	Surprisingly, mutant frequency induced by BaP at the hypoxanthine-guanine phosphribosyltransferase (HPRT) locus was decreased by pretreatment with TCDD.	Benzo(a)pyrene	42-45	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-104
23036853-8	2013	Among the enzymes catalyzing BaP oxidation and conjugation, cytochrome P450 1A1, 1A2, 3A4 and UDP-glucuronosyltransferase 1A1 mRNAs were induced by the exposure to TCDD.	Benzo(a)pyrene	29-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	60-79
23036853-8	2013	Among the enzymes catalyzing BaP oxidation and conjugation, cytochrome P450 1A1, 1A2, 3A4 and UDP-glucuronosyltransferase 1A1 mRNAs were induced by the exposure to TCDD.	Benzo(a)pyrene	29-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	94-125
23036853-10	2013	Further experiments using "Tet-On" cytochrome P450 1A1-overexpressing cells and a recombinant cytochrome P450 1A1 enzyme demonstrated that this is the key enzyme involved in the biotransformation of BaP, that is, both production and inactivation of BPDE.	Benzo(a)pyrene	199-202	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-54
22410783-7	2013	In comparison, SHD cells immortalized by the powerful polycyclic hydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in the DNA-binding domain of p53 coupled with INK4 alterations such as loss of expression of p15.	Benzo(a)pyrene	88-102	tumor protein p53	Homo sapiens	169-172
22410783-7	2013	In comparison, SHD cells immortalized by the powerful polycyclic hydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in the DNA-binding domain of p53 coupled with INK4 alterations such as loss of expression of p15.	Benzo(a)pyrene	88-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	186-190
22410783-7	2013	In comparison, SHD cells immortalized by the powerful polycyclic hydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in the DNA-binding domain of p53 coupled with INK4 alterations such as loss of expression of p15.	Benzo(a)pyrene	88-102	cyclin dependent kinase inhibitor 2B	Homo sapiens	233-236
23844580-9	2013	The highest concentration of benzo(a)pyrene (BaP) detected was 0.57 microg kg-1 in milk powder.	Benzo(a)pyrene	29-43	prohibitin 2	Homo sapiens	45-48
23489008-1	2013	While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear.	Benzo(a)pyrene	127-129	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	81-97
23489008-1	2013	While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear.	Benzo(a)pyrene	127-129	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	99-104
23548307-8	2013	RESULTS: Nineteen of 20 patients were BP allergic (positive SPT and/or CAP results for BP extract and Bet v 1).	Benzo(a)pyrene	38-40	delta/notch like EGF repeat containing	Homo sapiens	102-105
23647110-5	2013	Using TEF approaches on the mean concentration PAH data, benzo[a]pyrene and dibenz[ah]anthracene contributed the highest carcinogenic exposure equivalent.	Benzo(a)pyrene	57-71	TEF transcription factor, PAR bZIP family member	Homo sapiens	6-9
22805987-2	2013	Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), may have a role in this increased risk.	Benzo(a)pyrene	74-88	prohibitin 2	Homo sapiens	90-93
23257732-7	2013	Interestingly, IL-6 mRNA expression dramatically increased in TH+CFA+BP-induced EAO; however, no apparent change in IL-6 mRNA expression occurred in TH-induced EAO.	Benzo(a)pyrene	69-71	interleukin 6	Mus musculus	15-19
24362093-0	2013	Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.	Benzo(a)pyrene	26-40	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	58-77
24362093-0	2013	Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.	Benzo(a)pyrene	26-40	cytochrome b5 type A	Rattus norvegicus	101-114
24362093-1	2013	OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	121-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-37
24362093-1	2013	OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	121-135	prohibitin 2	Homo sapiens	137-140
24362093-1	2013	OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	121-135	epoxide hydrolase 1	Homo sapiens	163-191
24362093-1	2013	OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	121-135	epoxide hydrolase 1, microsomal	Mus musculus	193-196
23596707-1	2013	OBJECTIVE: To evaluate the association between DNA damage repair capacity induced by environment carcinogen benzo[a] pyrene (B [a] P) and ERCC2/XPD single nucleotide polymorphisms(SNP).	Benzo(a)pyrene	108-123	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	138-143
23147572-4	2013	Moreover, GNMT exerts protective effects against the cytotoxicity and carcinogenicity of benzo(a)pyrene and aflatoxin B(1) in vitro and in vivo.	Benzo(a)pyrene	89-103	glycine N-methyltransferase	Mus musculus	10-14
23596707-1	2013	OBJECTIVE: To evaluate the association between DNA damage repair capacity induced by environment carcinogen benzo[a] pyrene (B [a] P) and ERCC2/XPD single nucleotide polymorphisms(SNP).	Benzo(a)pyrene	108-123	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	144-147
23099427-9	2012	Benzo[a]pyrene (BaP) was detected using an immunological reaction by measuring the alkaline phosphatase (AP) enzymatic reaction towards the substrate para-amino phenyl phosphate (pAPP).	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
22960141-1	2012	In the current investigation the ameliorative effect of 2% extract of green tea (GT) and white tea (WT) against benzo(a)pyrene (BaP) induced toxicity and DNA damage has been studied in liver and lung of Balb/c mice (8 animals per group).	Benzo(a)pyrene	112-126	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	95-98
22960446-0	2012	Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats.	Benzo(a)pyrene	21-35	steroidogenic acute regulatory protein	Rattus norvegicus	116-120
22960446-4	2012	BaP exposure was confirmed through the induction of liver and testis CYP1A1 mRNA expression at PND 8 (i.e., immediately after exposure).	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	69-75
22960446-10	2012	Our results indicate that neonatal exposure to BaP damages testosterone production and sperm counts in the long term, possibly as a result of epigenetic regulation in the StAR promoter region.	Benzo(a)pyrene	47-50	steroidogenic acute regulatory protein	Rattus norvegicus	171-175
22960141-1	2012	In the current investigation the ameliorative effect of 2% extract of green tea (GT) and white tea (WT) against benzo(a)pyrene (BaP) induced toxicity and DNA damage has been studied in liver and lung of Balb/c mice (8 animals per group).	Benzo(a)pyrene	128-131	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	95-98
23365266-6	2012	Pigs fed BPF-EGF showed increased daily BW gain (410 vs. 260 g/d; P &lt; 0.01) and gain:feed (0.67 vs. 0.58; P &lt; 0.05) compared to BPF-Con pigs in wk 3 postweaning; this was comparable to values for the BP-Con group (400 g/d and 0.64).	Benzo(a)pyrene	9-11	epidermal growth factor	Sus scrofa	13-16
22531968-3	2012	The BP treatment resulted in a significant increase in the formation of micronuclei as well as in the protein expression of bcl-2 in the lungs of mice.	Benzo(a)pyrene	4-6	B cell leukemia/lymphoma 2	Mus musculus	124-129
22531968-4	2012	On the other hand, a significant decrease was observed in the number of apoptotic cells and protein expression of bax in the lungs of BP-treated mice.	Benzo(a)pyrene	134-136	BCL2-associated X protein	Mus musculus	114-117
22531968-7	2012	Moreover, phytochemicals in combination significantly reduced the protein expression of bcl-2 in BP-treated mice.	Benzo(a)pyrene	97-99	B cell leukemia/lymphoma 2	Mus musculus	88-93
23059060-7	2012	The activity of AHH in ovarian and liver tissues and concentrations of BaP 7,8-diol and BaP 3,6-dione metabolites increased in an exposure concentration-dependent manner.	Benzo(a)pyrene	71-74	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	16-19
22249251-8	2012	Exposure of skin and keratinocytes to the chemical stress agent benzo(a)pyrene led to induction of NQO1 and stabilization of C/EBPalpha protein, resulting in an increase in p63 RNA and protein in wild-type but not in NQO1-/- mice.	Benzo(a)pyrene	64-78	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	125-135
23089061-6	2012	Results showed most of the 16 PAHs tested were degraded within 2-4 h. Using (14)C-labled phenanthrene and benzo(a)pyrene, we demonstrated that the wax matrix of the candle initially adsorbs the PAH, but then releases the PAH back into solution as transformed, more water soluble products.	Benzo(a)pyrene	106-120	phenylalanine hydroxylase	Homo sapiens	30-33
23089061-6	2012	Results showed most of the 16 PAHs tested were degraded within 2-4 h. Using (14)C-labled phenanthrene and benzo(a)pyrene, we demonstrated that the wax matrix of the candle initially adsorbs the PAH, but then releases the PAH back into solution as transformed, more water soluble products.	Benzo(a)pyrene	106-120	phenylalanine hydroxylase	Homo sapiens	194-197
23148846-9	2012	Cell wall dynamics are also affected in blr mutant plants, and BLR has previously been shown to regulate vascular development in conjunction with BP.	Benzo(a)pyrene	146-148	POX (plant homeobox) family protein	Arabidopsis thaliana	63-66
22486318-7	2012	Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs.	Benzo(a)pyrene	11-25	aryl-hydrocarbon receptor	Mus musculus	49-52
22486318-7	2012	Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs.	Benzo(a)pyrene	11-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	67-81
22486318-7	2012	Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs.	Benzo(a)pyrene	27-30	aryl-hydrocarbon receptor	Mus musculus	49-52
22486318-7	2012	Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs.	Benzo(a)pyrene	27-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	67-81
22828138-0	2012	Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.	Benzo(a)pyrene	0-14	transformation related protein 53, pseudogene	Mus musculus	65-68
22828138-0	2012	Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.	Benzo(a)pyrene	16-18	transformation related protein 53, pseudogene	Mus musculus	65-68
22828138-3	2012	When mice were fed 100 ppm BP for 28 days, BP-induced DNA damage measured in esophagus, liver and lung was typically higher in Xpa(-/-)p53(+/-) mice, compared with WT mice.	Benzo(a)pyrene	27-29	xeroderma pigmentosum, complementation group A	Mus musculus	127-130
22828138-3	2012	When mice were fed 100 ppm BP for 28 days, BP-induced DNA damage measured in esophagus, liver and lung was typically higher in Xpa(-/-)p53(+/-) mice, compared with WT mice.	Benzo(a)pyrene	27-29	transformation related protein 53, pseudogene	Mus musculus	135-138
22828138-3	2012	When mice were fed 100 ppm BP for 28 days, BP-induced DNA damage measured in esophagus, liver and lung was typically higher in Xpa(-/-)p53(+/-) mice, compared with WT mice.	Benzo(a)pyrene	43-45	xeroderma pigmentosum, complementation group A	Mus musculus	127-130
22828138-3	2012	When mice were fed 100 ppm BP for 28 days, BP-induced DNA damage measured in esophagus, liver and lung was typically higher in Xpa(-/-)p53(+/-) mice, compared with WT mice.	Benzo(a)pyrene	43-45	transformation related protein 53, pseudogene	Mus musculus	135-138
22837390-0	2012	Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages.	Benzo(a)pyrene	39-53	vitamin D receptor	Homo sapiens	0-18
22837390-0	2012	Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages.	Benzo(a)pyrene	39-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-75
22837390-1	2012	Benzo[a]pyrene (BaP) activates the aryl hydrocarbon (AHR) and induces the expression of genes involved in xenobiotic metabolism, including CYP1A1.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
22837390-1	2012	Benzo[a]pyrene (BaP) activates the aryl hydrocarbon (AHR) and induces the expression of genes involved in xenobiotic metabolism, including CYP1A1.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	53-56
22837390-1	2012	Benzo[a]pyrene (BaP) activates the aryl hydrocarbon (AHR) and induces the expression of genes involved in xenobiotic metabolism, including CYP1A1.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-145
22842474-6	2012	Benzo[a]pyrene (BaP) ranged between 110 and 250 mug CAF(-1), accounting regularly for 5-15% of the total carcinogenic PAHs.	Benzo(a)pyrene	0-14	chromatin assembly factor 1 subunit A	Homo sapiens	52-58
22842474-6	2012	Benzo[a]pyrene (BaP) ranged between 110 and 250 mug CAF(-1), accounting regularly for 5-15% of the total carcinogenic PAHs.	Benzo(a)pyrene	16-19	chromatin assembly factor 1 subunit A	Homo sapiens	52-58
23026235-2	2012	AhR is ligand activated transcription factor with high affinities for aromatic planar compounds such as beta-naphthoflavone (BNF), 3-methylcholanthrene (3-MC), benzo[a]pyrene (BaP) or dioxin (TCDD).	Benzo(a)pyrene	160-174	aryl hydrocarbon receptor	Rattus norvegicus	0-3
23026235-2	2012	AhR is ligand activated transcription factor with high affinities for aromatic planar compounds such as beta-naphthoflavone (BNF), 3-methylcholanthrene (3-MC), benzo[a]pyrene (BaP) or dioxin (TCDD).	Benzo(a)pyrene	176-179	aryl hydrocarbon receptor	Rattus norvegicus	0-3
22735861-6	2012	RESULTS: Hematological parameters and the histochemical analysis of mast cells showed abnormal changes, and the immunoblotting analysis revealed increased protein expression of TNF-alpha, IL-6, COX-2 and NF-kappaB in lung cancer-challenged mice administered with benzo(a)pyrene.	Benzo(a)pyrene	263-277	tumor necrosis factor	Mus musculus	177-186
23163997-12	2012	The number of PML was significantly increased in SG and SL and BP groups with respect to CG (P &lt; .05).	Benzo(a)pyrene	63-65	PML nuclear body scaffold	Rattus norvegicus	14-17
22949056-8	2012	Interestingly, the frequency of PIK3CA gene mutations             increased with the biological aggressiveness of all BP-NETs, except LCNECs.	Benzo(a)pyrene	118-120	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	32-38
23387201-0	2012	[Mechanism of DNA polymerase beta hyper-expression in malignant transformation induced by benzo[a] pyrene].	Benzo(a)pyrene	90-105	DNA polymerase beta	Homo sapiens	14-33
23387201-1	2012	OBJECTIVE: To explore the mechanism of the hyper-expression of DNA polymerase beta (polbeta) in benzo[a]pyrene (BaP) induced malignant transformed cell (polbeta-T).	Benzo(a)pyrene	96-110	DNA polymerase beta	Homo sapiens	63-82
23387201-1	2012	OBJECTIVE: To explore the mechanism of the hyper-expression of DNA polymerase beta (polbeta) in benzo[a]pyrene (BaP) induced malignant transformed cell (polbeta-T).	Benzo(a)pyrene	96-110	DNA polymerase beta	Homo sapiens	84-91
23387201-1	2012	OBJECTIVE: To explore the mechanism of the hyper-expression of DNA polymerase beta (polbeta) in benzo[a]pyrene (BaP) induced malignant transformed cell (polbeta-T).	Benzo(a)pyrene	96-110	DNA polymerase beta	Homo sapiens	153-160
23387201-1	2012	OBJECTIVE: To explore the mechanism of the hyper-expression of DNA polymerase beta (polbeta) in benzo[a]pyrene (BaP) induced malignant transformed cell (polbeta-T).	Benzo(a)pyrene	112-115	DNA polymerase beta	Homo sapiens	63-82
23387201-1	2012	OBJECTIVE: To explore the mechanism of the hyper-expression of DNA polymerase beta (polbeta) in benzo[a]pyrene (BaP) induced malignant transformed cell (polbeta-T).	Benzo(a)pyrene	112-115	DNA polymerase beta	Homo sapiens	84-91
23387201-1	2012	OBJECTIVE: To explore the mechanism of the hyper-expression of DNA polymerase beta (polbeta) in benzo[a]pyrene (BaP) induced malignant transformed cell (polbeta-T).	Benzo(a)pyrene	112-115	DNA polymerase beta	Homo sapiens	153-160
22249251-8	2012	Exposure of skin and keratinocytes to the chemical stress agent benzo(a)pyrene led to induction of NQO1 and stabilization of C/EBPalpha protein, resulting in an increase in p63 RNA and protein in wild-type but not in NQO1-/- mice.	Benzo(a)pyrene	64-78	NAD(P)H dehydrogenase, quinone 1	Mus musculus	99-103
23036591-8	2012	The response of monocytes and monocyte-derived dendritic cells (mo-DCs) to the AHR agonist, benzo(a)pyrene (BaP) was compared in vitro.	Benzo(a)pyrene	92-106	aryl hydrocarbon receptor	Homo sapiens	79-82
23036591-8	2012	The response of monocytes and monocyte-derived dendritic cells (mo-DCs) to the AHR agonist, benzo(a)pyrene (BaP) was compared in vitro.	Benzo(a)pyrene	108-111	aryl hydrocarbon receptor	Homo sapiens	79-82
23036591-16	2012	Exposure to BaP affected mo-DC function as demonstrated by decreased IL6 expression induced by PolyI:C, without affecting indoleamine 2,3 dioxygenase (IDO)1 expression.	Benzo(a)pyrene	12-15	interleukin 6	Homo sapiens	69-72
22249251-8	2012	Exposure of skin and keratinocytes to the chemical stress agent benzo(a)pyrene led to induction of NQO1 and stabilization of C/EBPalpha protein, resulting in an increase in p63 RNA and protein in wild-type but not in NQO1-/- mice.	Benzo(a)pyrene	64-78	transformation related protein 63	Mus musculus	173-176
22249251-8	2012	Exposure of skin and keratinocytes to the chemical stress agent benzo(a)pyrene led to induction of NQO1 and stabilization of C/EBPalpha protein, resulting in an increase in p63 RNA and protein in wild-type but not in NQO1-/- mice.	Benzo(a)pyrene	64-78	NAD(P)H dehydrogenase, quinone 1	Mus musculus	217-221
22643862-4	2012	In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonized by the two isothiocyanates.	Benzo(a)pyrene	47-61	aryl hydrocarbon receptor	Rattus norvegicus	27-38
22643862-5	2012	In further studies, it was demonstrated that R,S-sulforaphane could both prevent the interaction of and displace already bound benzo[a]pyrene from the Ah receptor, but no concentration dependency was observed with respect to the isothiocyanate.	Benzo(a)pyrene	127-141	aryl hydrocarbon receptor	Rattus norvegicus	151-162
22643862-7	2012	Of the two isomers of R,S-sulforaphane, the naturally occurring R-isomer was more effective than the S-isomer in antagonizing the activation of the Ah receptor by benzo[a]pyrene.	Benzo(a)pyrene	163-177	aryl hydrocarbon receptor	Rattus norvegicus	148-159
22643862-4	2012	In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonized by the two isothiocyanates.	Benzo(a)pyrene	47-61	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	86-92
22670597-6	2012	This review will focus on the potential role of ET-1 in renal disease with an emphasis on its BP-independent actions.	Benzo(a)pyrene	94-96	endothelin 1	Homo sapiens	48-52
22727790-7	2012	Benzo(a)pyrene treatment also suppressed apo A-I mRNA and gene promoter activity.	Benzo(a)pyrene	0-14	apolipoprotein A1	Homo sapiens	41-48
22913541-0	2012	Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods.	Benzo(a)pyrene	57-71	DNA methyltransferase 3A	Mus musculus	32-38
22581694-4	2012	The transduction of AhR from the cytoplasm to the nucleus and the increase of AhR-responsive genes; that is, cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), and aryl-hydrocarbon receptor repressor (AhRR), expression was induced by BaP exposure in both HPDLCs.	Benzo(a)pyrene	243-246	aryl hydrocarbon receptor	Homo sapiens	20-23
22581694-4	2012	The transduction of AhR from the cytoplasm to the nucleus and the increase of AhR-responsive genes; that is, cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), and aryl-hydrocarbon receptor repressor (AhRR), expression was induced by BaP exposure in both HPDLCs.	Benzo(a)pyrene	243-246	aryl hydrocarbon receptor	Homo sapiens	78-81
22581694-4	2012	The transduction of AhR from the cytoplasm to the nucleus and the increase of AhR-responsive genes; that is, cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), and aryl-hydrocarbon receptor repressor (AhRR), expression was induced by BaP exposure in both HPDLCs.	Benzo(a)pyrene	243-246	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	109-128
22581694-5	2012	BaP treatment significantly enhanced MMP-1 mRNA expression and MMP-1 protein production, while markedly suppressing COL-I and a-SMA mRNA expression in both HPDLCs.	Benzo(a)pyrene	0-3	matrix metallopeptidase 1	Homo sapiens	37-42
22581694-5	2012	BaP treatment significantly enhanced MMP-1 mRNA expression and MMP-1 protein production, while markedly suppressing COL-I and a-SMA mRNA expression in both HPDLCs.	Benzo(a)pyrene	0-3	matrix metallopeptidase 1	Homo sapiens	63-68
22581694-5	2012	BaP treatment significantly enhanced MMP-1 mRNA expression and MMP-1 protein production, while markedly suppressing COL-I and a-SMA mRNA expression in both HPDLCs.	Benzo(a)pyrene	0-3	actin alpha 1, skeletal muscle	Homo sapiens	126-131
22581694-6	2012	Furthermore, these BaP-treated HPDLCs fell into apoptotic cell death as evidenced by induction in annexin V and caspase-3/7 staining and reduction of total cell number and Bcl-2 mRNA expression.	Benzo(a)pyrene	19-22	annexin A5	Homo sapiens	98-107
22581694-6	2012	Furthermore, these BaP-treated HPDLCs fell into apoptotic cell death as evidenced by induction in annexin V and caspase-3/7 staining and reduction of total cell number and Bcl-2 mRNA expression.	Benzo(a)pyrene	19-22	caspase 3	Homo sapiens	112-121
22581694-6	2012	Furthermore, these BaP-treated HPDLCs fell into apoptotic cell death as evidenced by induction in annexin V and caspase-3/7 staining and reduction of total cell number and Bcl-2 mRNA expression.	Benzo(a)pyrene	19-22	BCL2 apoptosis regulator	Homo sapiens	172-177
22581694-7	2012	Thus, BaP exposure altered the expression of ECM-related molecules and induced apoptosis in HPDLCs through activation of the AhR pathway.	Benzo(a)pyrene	6-9	aryl hydrocarbon receptor	Homo sapiens	125-128
23107701-5	2012	The extracts also inhibited the activity of CYP3A4, whose expression was induced by 1,25-dihydroxyvitamin D(3), and of CYP1A1, induced by benzo(a)pyrene.	Benzo(a)pyrene	138-152	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	44-50
23107701-5	2012	The extracts also inhibited the activity of CYP3A4, whose expression was induced by 1,25-dihydroxyvitamin D(3), and of CYP1A1, induced by benzo(a)pyrene.	Benzo(a)pyrene	138-152	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	119-125
22759596-1	2012	Benzo[a]pyrene (BaP) is a widespread environmental carcinogen activated by cytochrome P450 (P450) enzymes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
21452393-1	2012	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	48-62	prohibitin 2	Homo sapiens	64-69
21452393-1	2012	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	48-62	aryl hydrocarbon receptor	Homo sapiens	184-209
21452393-1	2012	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	48-62	aryl hydrocarbon receptor	Homo sapiens	211-214
23019814-2	2012	The study permitted to identify the coke oven as the main PAH source in Genoa, causing constant exceeding of benzo(a)pyrene (BaP) air quality target (1.0 ng/m3) in the urban area till 1,900 meters distance downwind the plant.	Benzo(a)pyrene	109-123	prohibitin 2	Homo sapiens	125-128
22659362-3	2012	Based on the structure of a closely related protein HIF2alpha, we modeled the AHR ligand binding domain (LBD) bound to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BaP) and identified residues that control ligand preferences by shape and H-bond potential.	Benzo(a)pyrene	166-180	endothelial PAS domain protein 1	Homo sapiens	52-61
22659362-3	2012	Based on the structure of a closely related protein HIF2alpha, we modeled the AHR ligand binding domain (LBD) bound to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BaP) and identified residues that control ligand preferences by shape and H-bond potential.	Benzo(a)pyrene	166-180	aryl hydrocarbon receptor	Homo sapiens	78-81
22659362-3	2012	Based on the structure of a closely related protein HIF2alpha, we modeled the AHR ligand binding domain (LBD) bound to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BaP) and identified residues that control ligand preferences by shape and H-bond potential.	Benzo(a)pyrene	182-185	endothelial PAS domain protein 1	Homo sapiens	52-61
22659362-3	2012	Based on the structure of a closely related protein HIF2alpha, we modeled the AHR ligand binding domain (LBD) bound to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BaP) and identified residues that control ligand preferences by shape and H-bond potential.	Benzo(a)pyrene	182-185	aryl hydrocarbon receptor	Homo sapiens	78-81
22561278-1	2012	Chemical contaminants, such as benzo[a]pyrene (B[a]P), may modulate transcriptional responses in cells via the activation of aryl hydrocarbon receptor (AhR) or through responses to DNA damage following adduct formation.	Benzo(a)pyrene	31-45	aryl hydrocarbon receptor	Homo sapiens	125-150
22561278-1	2012	Chemical contaminants, such as benzo[a]pyrene (B[a]P), may modulate transcriptional responses in cells via the activation of aryl hydrocarbon receptor (AhR) or through responses to DNA damage following adduct formation.	Benzo(a)pyrene	31-45	aryl hydrocarbon receptor	Homo sapiens	152-155
22562770-5	2012	METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression.	Benzo(a)pyrene	36-50	interferon gamma	Homo sapiens	122-130
22562770-5	2012	METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression.	Benzo(a)pyrene	36-50	interleukin 4	Homo sapiens	135-138
22562770-5	2012	METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression.	Benzo(a)pyrene	52-55	interferon gamma	Homo sapiens	122-130
22562770-5	2012	METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression.	Benzo(a)pyrene	52-55	interleukin 4	Homo sapiens	135-138
22562770-8	2012	RESULTS: In vitro exposure of the cell models to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increased promoter hypermethylation and reduced expression of IFNgamma, but not IL4.	Benzo(a)pyrene	91-94	interferon gamma	Homo sapiens	166-174
22562770-8	2012	RESULTS: In vitro exposure of the cell models to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increased promoter hypermethylation and reduced expression of IFNgamma, but not IL4.	Benzo(a)pyrene	91-94	interleukin 4	Homo sapiens	184-187
22561122-1	2012	Most studies about functions of aryl hydrocarbon receptor (AhR) in the pathogenesis of asthma have been carried out with non-physiological industrial by-products such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene.	Benzo(a)pyrene	210-224	aryl-hydrocarbon receptor	Mus musculus	32-57
22561122-1	2012	Most studies about functions of aryl hydrocarbon receptor (AhR) in the pathogenesis of asthma have been carried out with non-physiological industrial by-products such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene.	Benzo(a)pyrene	210-224	aryl-hydrocarbon receptor	Mus musculus	59-62
25683418-7	2012	This study indicates that quercetin metabolites decrease the BaP-induced harmful effect of beta-carotene in A549 cells by downregulating the expression of CYP1A1/1A2, at least in part.	Benzo(a)pyrene	61-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-161
22776036-11	2012	Independent determinants of CKD-eGFR &lt;60 were increasing age at diabetes diagnosis, diabetes duration, total cholesterol and systolic BP.	Benzo(a)pyrene	137-139	epidermal growth factor receptor	Homo sapiens	32-36
22647781-11	2012	CONCLUSIONS: The ACE I/D polymorphism, especially the DD genotype, can be interpreted as a major factor in association between LBW and high BP levels.	Benzo(a)pyrene	140-142	angiotensin I converting enzyme	Homo sapiens	17-20
22380849-4	2012	Two transcription factors, ASYMMETRIC LEAVES 1 (AS1) and AS2, are known to form a protein complex to repress BP, KNAT2 and KNAT6.	Benzo(a)pyrene	109-111	myb-like HTH transcriptional regulator family protein	Arabidopsis thaliana	27-46
23016337-1	2012	The degradation of Benzo(a)pyrene (BaP) by potassium ferrate was researched by means of multiple fluorescence spectroscopic methods such as synchronous, time-scan, excitation emission matrix (EEM) and photometry, under the optimal condition.	Benzo(a)pyrene	19-33	prohibitin 2	Homo sapiens	35-38
22470100-1	2012	Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family,             which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene.	Benzo(a)pyrene	165-179	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
22470100-1	2012	Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family,             which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene.	Benzo(a)pyrene	165-179	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
22470100-5	2012	Of note, benzo(a)pyrene, a major inducer of CYP1A1 transcription,             decreased the expression of miR-892a.	Benzo(a)pyrene	9-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
22470100-5	2012	Of note, benzo(a)pyrene, a major inducer of CYP1A1 transcription,             decreased the expression of miR-892a.	Benzo(a)pyrene	9-23	microRNA 892a	Homo sapiens	106-114
22470100-6	2012	Moreover, the miR-892a-induced CYP1A1 repression             inhibited the benzo(a)pyrene-mediated decrease in cell viability.	Benzo(a)pyrene	75-89	MLX interacting protein	Homo sapiens	14-17
22470100-6	2012	Moreover, the miR-892a-induced CYP1A1 repression             inhibited the benzo(a)pyrene-mediated decrease in cell viability.	Benzo(a)pyrene	75-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
22796920-0	2012	Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene.	Benzo(a)pyrene	141-155	dual specificity phosphatase 22	Homo sapiens	19-50
21739481-4	2012	In this study, a single topical application of either 7,12-dimethylbenz[a]anthracene (DMBA) or benzo[a]pyrene (B[a]P), alone, was found to elicit squamous cell carcinomas (SCCs) in the BK5.EP1 transgenic mice, but not in WT mice.	Benzo(a)pyrene	95-109	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	189-192
22380849-4	2012	Two transcription factors, ASYMMETRIC LEAVES 1 (AS1) and AS2, are known to form a protein complex to repress BP, KNAT2 and KNAT6.	Benzo(a)pyrene	109-111	myb-like HTH transcriptional regulator family protein	Arabidopsis thaliana	48-51
22380849-4	2012	Two transcription factors, ASYMMETRIC LEAVES 1 (AS1) and AS2, are known to form a protein complex to repress BP, KNAT2 and KNAT6.	Benzo(a)pyrene	109-111	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	57-60
22380849-4	2012	Two transcription factors, ASYMMETRIC LEAVES 1 (AS1) and AS2, are known to form a protein complex to repress BP, KNAT2 and KNAT6.	Benzo(a)pyrene	109-111	homeobox knotted-like protein	Arabidopsis thaliana	113-118
22380849-4	2012	Two transcription factors, ASYMMETRIC LEAVES 1 (AS1) and AS2, are known to form a protein complex to repress BP, KNAT2 and KNAT6.	Benzo(a)pyrene	109-111	homeobox protein knotted-1-like 6	Arabidopsis thaliana	123-128
26105275-17	2012	CONCLUSION: Administration of PlGF resulted in a reduction in BP and proteinuria without significantly affecting total sFLT-1 levels.	Benzo(a)pyrene	62-64	placental growth factor	Homo sapiens	30-34
22822207-5	2012	JLO acts in a trimeric protein complex with ASYMMETRIC LEAVES2 (AS2), another LBD protein, and AS1 to suppress BP expression in lateral organs.	Benzo(a)pyrene	111-113	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	0-3
22822207-5	2012	JLO acts in a trimeric protein complex with ASYMMETRIC LEAVES2 (AS2), another LBD protein, and AS1 to suppress BP expression in lateral organs.	Benzo(a)pyrene	111-113	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	44-62
22822207-5	2012	JLO acts in a trimeric protein complex with ASYMMETRIC LEAVES2 (AS2), another LBD protein, and AS1 to suppress BP expression in lateral organs.	Benzo(a)pyrene	111-113	Lateral organ boundaries (LOB) domain family protein	Arabidopsis thaliana	64-67
22822207-5	2012	JLO acts in a trimeric protein complex with ASYMMETRIC LEAVES2 (AS2), another LBD protein, and AS1 to suppress BP expression in lateral organs.	Benzo(a)pyrene	111-113	myb-like HTH transcriptional regulator family protein	Arabidopsis thaliana	95-98
22394341-0	2012	Benzo(a)pyrene induces hepatic AKR1A1 mRNA expression in tilapia fish (Oreochromis niloticus).	Benzo(a)pyrene	0-14	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	31-37
22394341-2	2012	AKR1A1 is one of the five AKRs (AKR1A1 and 1C1-1C4) implicated in the metabolic benzo(a)pyrene (BaP) activation to reactive BaP 7,8-dione.	Benzo(a)pyrene	80-94	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	0-6
22394341-2	2012	AKR1A1 is one of the five AKRs (AKR1A1 and 1C1-1C4) implicated in the metabolic benzo(a)pyrene (BaP) activation to reactive BaP 7,8-dione.	Benzo(a)pyrene	80-94	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	32-38
22394341-2	2012	AKR1A1 is one of the five AKRs (AKR1A1 and 1C1-1C4) implicated in the metabolic benzo(a)pyrene (BaP) activation to reactive BaP 7,8-dione.	Benzo(a)pyrene	96-99	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	0-6
22394341-2	2012	AKR1A1 is one of the five AKRs (AKR1A1 and 1C1-1C4) implicated in the metabolic benzo(a)pyrene (BaP) activation to reactive BaP 7,8-dione.	Benzo(a)pyrene	96-99	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	32-38
22394341-4	2012	Although the presence of AKR1A1 in fish has been reported, its tissue distribution in tilapia (Oreochromis niloticus) and AKR1A1 inducibility by BaP are not known yet.	Benzo(a)pyrene	145-148	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	122-128
22394341-6	2012	Therefore, BaP effects on AKR1A1 and CYP1A gene expressions in tilapia, a species of commercial interest, were investigated by real-time RT-PCR.	Benzo(a)pyrene	11-14	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	26-32
22394341-9	2012	BaP exposure resulted in statistically significant AKR1A1 and CYP1A mRNA induction in liver (20- and 120-fold, respectively) at 24 h. On the other hand, ethoxyquin (EQ) was used as control inducer for AKR1A1 mRNA.	Benzo(a)pyrene	0-3	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	51-57
22394341-9	2012	BaP exposure resulted in statistically significant AKR1A1 and CYP1A mRNA induction in liver (20- and 120-fold, respectively) at 24 h. On the other hand, ethoxyquin (EQ) was used as control inducer for AKR1A1 mRNA.	Benzo(a)pyrene	0-3	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	201-207
22394341-11	2012	Our results suggest that teleost AKR1A1, in addition to CYP1A, are inducible by BaP.	Benzo(a)pyrene	80-83	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	33-39
22394341-12	2012	The mechanism of AKR1A1 induction by BaP and its role in fish susceptibility to BaP toxic effects remains to be elucidated.	Benzo(a)pyrene	37-40	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	17-23
22394341-12	2012	The mechanism of AKR1A1 induction by BaP and its role in fish susceptibility to BaP toxic effects remains to be elucidated.	Benzo(a)pyrene	80-83	alcohol dehydrogenase [NADP(+)]	Oreochromis niloticus	17-23
22531821-0	2012	Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene.	Benzo(a)pyrene	131-145	carbonyl reductase 1	Homo sapiens	13-33
22531821-0	2012	Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene.	Benzo(a)pyrene	131-145	carbonyl reductase 1	Homo sapiens	35-39
22619112-5	2012	Initial studies characterizing the metabolic capacity of proliferating lacZ primary hepatocytes indicated that these cells retained at least some activities important for xenobiotic metabolism: cytochrome P450 1A1 enzyme activities were markedly increased in the hepatocytes after exposure to benzo[a]pyrene, and also UDP-glucuronosyl transferase and glutathione-S-transferase activities, both Phase II enzymes, were detected.	Benzo(a)pyrene	293-307	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	194-213
22619112-5	2012	Initial studies characterizing the metabolic capacity of proliferating lacZ primary hepatocytes indicated that these cells retained at least some activities important for xenobiotic metabolism: cytochrome P450 1A1 enzyme activities were markedly increased in the hepatocytes after exposure to benzo[a]pyrene, and also UDP-glucuronosyl transferase and glutathione-S-transferase activities, both Phase II enzymes, were detected.	Benzo(a)pyrene	293-307	hematopoietic prostaglandin D synthase	Mus musculus	351-376
22298307-6	2012	The results showed that GSTP1 knockdown significantly increased the efficiency of benzo(a)pyrene-induced 16HBE cell transformation.	Benzo(a)pyrene	82-96	glutathione S-transferase pi 1	Homo sapiens	24-29
22281303-6	2012	At least four of these agents are likely to lead to POF in descendents (ethylene glycol methyl ether; 2,2-bis(bromomethyl)-1,3-propanediol; benzo[a]pyrene; dimethylbenzantracene).	Benzo(a)pyrene	140-154	POF1B actin binding protein	Homo sapiens	52-55
22382310-7	2012	In contrast, we found that HBE cells expressing H-Ras or c-Myc were transformed 8 or 12 weeks after BaP treatment.	Benzo(a)pyrene	100-103	HRas proto-oncogene, GTPase	Homo sapiens	48-53
22382310-7	2012	In contrast, we found that HBE cells expressing H-Ras or c-Myc were transformed 8 or 12 weeks after BaP treatment.	Benzo(a)pyrene	100-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	57-62
22856136-2	2012	Treatment of rats with benzo(a)pyren (BP) or 3-methylcholantrene (MC) significantly up-regulated CYP1A1, CYP1B1 gene expression in liver, uterus and ovary, whereas alfa-naphthoflavone (alpha-NF) did not have any effect.	Benzo(a)pyrene	38-40	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	97-103
22856136-2	2012	Treatment of rats with benzo(a)pyren (BP) or 3-methylcholantrene (MC) significantly up-regulated CYP1A1, CYP1B1 gene expression in liver, uterus and ovary, whereas alfa-naphthoflavone (alpha-NF) did not have any effect.	Benzo(a)pyrene	38-40	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	105-111
22856136-5	2012	BP produced an increase in ERalpha and cyclin D1 gene expression in rat liver.	Benzo(a)pyrene	0-2	estrogen receptor 1	Rattus norvegicus	27-34
22856136-5	2012	BP produced an increase in ERalpha and cyclin D1 gene expression in rat liver.	Benzo(a)pyrene	0-2	cyclin D1	Rattus norvegicus	39-48
22856136-8	2012	On the other hand, BP treatment caused an increase of the ERalpha and cyclin D1 mRNA levels (3,5- and 2,5-fold, respectively) in ovary, whereas MC and alpha-NF did not have any effects.	Benzo(a)pyrene	19-21	estrogen receptor 1	Rattus norvegicus	58-65
22856136-8	2012	On the other hand, BP treatment caused an increase of the ERalpha and cyclin D1 mRNA levels (3,5- and 2,5-fold, respectively) in ovary, whereas MC and alpha-NF did not have any effects.	Benzo(a)pyrene	19-21	cyclin D1	Rattus norvegicus	70-79
22269188-5	2012	We measured expression of GSTp2 in embryos exposed to individual and co-exposures of the PAHs benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), and fluoranthene (FL) as well as 3,3",4,4",5-pentachlorobiphenyl (PCB-126).	Benzo(a)pyrene	122-136	glutathione S-transferase pi 1.1	Danio rerio	26-31
22269188-5	2012	We measured expression of GSTp2 in embryos exposed to individual and co-exposures of the PAHs benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), and fluoranthene (FL) as well as 3,3",4,4",5-pentachlorobiphenyl (PCB-126).	Benzo(a)pyrene	138-141	glutathione S-transferase pi 1.1	Danio rerio	26-31
22269188-6	2012	GSTp2 mRNA expression was induced by exposure to BkF, BaP, PCB-126, and BaP+FL and BkF+FL co-exposure.	Benzo(a)pyrene	54-57	glutathione S-transferase pi 1.1	Danio rerio	0-5
22269188-6	2012	GSTp2 mRNA expression was induced by exposure to BkF, BaP, PCB-126, and BaP+FL and BkF+FL co-exposure.	Benzo(a)pyrene	72-75	glutathione S-transferase pi 1.1	Danio rerio	0-5
22269188-8	2012	GSTp2 knockdown exacerbated the toxicity caused by co-exposures to BkF+FL and BaP+FL.	Benzo(a)pyrene	78-81	glutathione S-transferase pi 1.1	Danio rerio	0-5
22266578-0	2012	Role of poly(ADP-ribose) glycohydrolase in the regulation of cell fate in response to benzo(a)pyrene.	Benzo(a)pyrene	86-100	poly(ADP-ribose) glycohydrolase	Homo sapiens	8-39
22143730-1	2012	OBJECTIVES: To determine whether there is a relationship between the total BP dose administered and the variations in serum CTX concentration.	Benzo(a)pyrene	75-77	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	124-127
22484021-7	2012	RESULTS: In the MDC-CVA, male, but not female, CYP4F2 M433 carriers had significantly higher levels of waist, triglycerides, BP and a composite sum of MetS phenotypes (MetS score) beside lower HDL-cholesterol respect to V-homozygotes.	Benzo(a)pyrene	125-127	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	47-53
22230649-5	2012	However, BP ECS but not UBP ECS treatment led to a significant, near 3-fold, increase in cell proliferation (p=0.026) and BDNF levels (p=0.01).	Benzo(a)pyrene	9-11	brain-derived neurotrophic factor	Rattus norvegicus	122-126
22409540-6	2012	Signaling in HepG2 cells exposed to soil PAH extracts corresponding to 1 muM benzo[a]pyrene was similar to that of 0.1 muM dibenzo[a,l]pyrene, a highly carcinogenic PAH known to produce persistent DNA damage.	Benzo(a)pyrene	77-91	phenylalanine hydroxylase	Homo sapiens	41-44
22409540-6	2012	Signaling in HepG2 cells exposed to soil PAH extracts corresponding to 1 muM benzo[a]pyrene was similar to that of 0.1 muM dibenzo[a,l]pyrene, a highly carcinogenic PAH known to produce persistent DNA damage.	Benzo(a)pyrene	77-91	latexin	Homo sapiens	73-76
22356885-8	2012	These results indicate that activation of glutamate and AT1-receptors in the PVN contributes to the maintenance of BP in hypertensive Dahl S rats, but not normotensive Dahl S and R rats.	Benzo(a)pyrene	115-117	angiotensin II receptor, type 1a	Rattus norvegicus	56-59
22374940-6	2012	Treatment of cell lines derived from oral leukoplakia (MSK-Leuk1) and skin (HaCaT) with benzo[a]pyrene (B[a]P), a prototypic PAH, induced CYP1A1 and CYP1B1 transcription, resulting in enhanced levels of message and protein.	Benzo(a)pyrene	88-102	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	138-144
22374940-6	2012	Treatment of cell lines derived from oral leukoplakia (MSK-Leuk1) and skin (HaCaT) with benzo[a]pyrene (B[a]P), a prototypic PAH, induced CYP1A1 and CYP1B1 transcription, resulting in enhanced levels of message and protein.	Benzo(a)pyrene	88-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	149-155
22245057-11	2012	Pre-treatment of Huh7 cells with SiO(2)-1% Ag-NPs followed by exposure to the inducer benzo(a)pyrene caused a significant reduced induction of CYP1A activity.	Benzo(a)pyrene	86-100	MIR7-3 host gene	Homo sapiens	17-21
22227637-0	2012	Gene expression analysis of ABC efflux transporters, CYP1A and GSTalpha in Nile tilapia after exposure to benzo(a)pyrene.	Benzo(a)pyrene	106-120	cytochrome P450 1A	Oreochromis niloticus	53-58
22227637-0	2012	Gene expression analysis of ABC efflux transporters, CYP1A and GSTalpha in Nile tilapia after exposure to benzo(a)pyrene.	Benzo(a)pyrene	106-120	glutathione S-transferase	Oreochromis niloticus	63-71
22227637-1	2012	The aim of this study was to evaluate the response of ABC transporters, CYP1A and class alpha (alpha) GST genes, upon water and dietary exposures to benzo(a)pyrene (BaP) in Oreochromis niloticus.	Benzo(a)pyrene	149-163	cytochrome P450 1A	Oreochromis niloticus	72-77
22227637-1	2012	The aim of this study was to evaluate the response of ABC transporters, CYP1A and class alpha (alpha) GST genes, upon water and dietary exposures to benzo(a)pyrene (BaP) in Oreochromis niloticus.	Benzo(a)pyrene	165-168	cytochrome P450 1A	Oreochromis niloticus	72-77
22227637-7	2012	In conclusion, this study has shown that transcriptional expression of some ABC transporters and CYP1A respond to the presence of BaP, indicating a possible involvement and cooperation in the detoxification process in Nile tilapia.	Benzo(a)pyrene	130-133	cytochrome P450 1A	Oreochromis niloticus	97-102
22317757-0	2012	Human DNA polymerase lambda catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair.	Benzo(a)pyrene	59-73	DNA polymerase lambda	Homo sapiens	6-27
22266578-6	2012	The role of PARG in the regulation of DNA damage induced by BaP is still unclear.	Benzo(a)pyrene	60-63	poly(ADP-ribose) glycohydrolase	Homo sapiens	12-16
22266578-7	2012	To gain insight into the function of PARG and PAR in response to BaP, we used lentiviral gene silencing to generate 16HBE cell lines with stably suppressed PARG, and determined parameters of cell death and cell cycle following BaP exposure.	Benzo(a)pyrene	65-68	poly(ADP-ribose) glycohydrolase	Homo sapiens	37-41
22266578-9	2012	BaP-induced cell death was regulated by PARG, the absence of which was beneficial for undamaged cells.	Benzo(a)pyrene	0-3	poly(ADP-ribose) glycohydrolase	Homo sapiens	40-44
22266578-10	2012	Our results further suggested that PARG probably has influence on ATM/p53 pathway and metabolic activation of BaP.	Benzo(a)pyrene	110-113	poly(ADP-ribose) glycohydrolase	Homo sapiens	35-39
22204985-0	2012	Cytochrome P450 1C1 complementary DNA cloning, sequence analysis and constitutive expression induced by benzo-a-pyrene in Nile tilapia (Oreochromis niloticus).	Benzo(a)pyrene	104-118	cytochrome P450 1C1	Oreochromis niloticus	0-19
22204985-2	2012	In this study, a new complementary DNA of the CYP1C subfamily encoding CYP1C1 was isolated from Nile tilapia (Oreochromis niloticus) liver after intracoelomic injection with benzo-a-pyrene (BaP).	Benzo(a)pyrene	174-188	cytochrome P450 1C1	Oreochromis niloticus	71-77
22204985-2	2012	In this study, a new complementary DNA of the CYP1C subfamily encoding CYP1C1 was isolated from Nile tilapia (Oreochromis niloticus) liver after intracoelomic injection with benzo-a-pyrene (BaP).	Benzo(a)pyrene	190-193	cytochrome P450 1C1	Oreochromis niloticus	71-77
22204985-7	2012	Furthermore, for measuring BaP induction of CYP1C1 mRNA in different organs of tilapia (O. niloticus), beta-actin gene as internal control was selected based on previous studies to assess their expression variability.	Benzo(a)pyrene	27-30	cytochrome P450 1C1	Oreochromis niloticus	44-50
20862736-1	2012	p53 can mediate DNA damage-induced apoptosis in various cell lines treated with Benzo(a)pyrene (BaP).	Benzo(a)pyrene	96-99	tumor protein p53	Homo sapiens	0-3
20862736-2	2012	However, the potential role of p73, one of the p53 family members, in BaP-induced apoptotic cell death remains to be determined.	Benzo(a)pyrene	70-73	tumor protein p73	Homo sapiens	31-34
20862736-2	2012	However, the potential role of p73, one of the p53 family members, in BaP-induced apoptotic cell death remains to be determined.	Benzo(a)pyrene	70-73	tumor protein p53	Homo sapiens	47-50
20862736-4	2012	In the two BaP-treated cell lines, we observed increased malondialdehyde (MDA) formation and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity at 4 h after the treatment; furthermore, at the time points of 4 and 12 h, we observed extremely high levels of DNA damage.	Benzo(a)pyrene	11-14	superoxide dismutase 1	Homo sapiens	103-123
20862736-4	2012	In the two BaP-treated cell lines, we observed increased malondialdehyde (MDA) formation and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity at 4 h after the treatment; furthermore, at the time points of 4 and 12 h, we observed extremely high levels of DNA damage.	Benzo(a)pyrene	11-14	superoxide dismutase 1	Homo sapiens	125-128
20862736-6	2012	Furthermore, in BaP-treated H1299 cells, only the p73 mRNA level was up-regulated.	Benzo(a)pyrene	16-19	tumor protein p73	Homo sapiens	50-53
22193384-1	2012	Signaling through both angiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excretion and arterial BP.	Benzo(a)pyrene	134-136	angiotensin II receptor type 1	Homo sapiens	35-48
22193384-1	2012	Signaling through both angiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excretion and arterial BP.	Benzo(a)pyrene	134-136	angiotensin II receptor type 1	Homo sapiens	50-54
21567390-0	2012	Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene.	Benzo(a)pyrene	108-122	aryl-hydrocarbon receptor	Mus musculus	0-25
21567390-5	2012	After confirming that chondrocytes express AHR during differentiation, we treated cells with a prototypical PAH found in CS, benzo(a)pyrene (BaP), or cigarette smoke extract (CSE).	Benzo(a)pyrene	141-144	phenylalanine hydroxylase	Mus musculus	108-111
21567390-8	2012	Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR-independent.	Benzo(a)pyrene	78-81	aryl-hydrocarbon receptor	Mus musculus	12-15
21567390-8	2012	Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR-independent.	Benzo(a)pyrene	78-81	aryl-hydrocarbon receptor	Mus musculus	35-38
21567390-8	2012	Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR-independent.	Benzo(a)pyrene	78-81	aryl-hydrocarbon receptor	Mus musculus	35-38
21920623-4	2012	Endocrine disruptor benzo[a]pyrene stimulated ERalpha(-) tumor growth dose dependently.	Benzo(a)pyrene	20-34	estrogen receptor 1	Homo sapiens	46-53
21920623-5	2012	Either of ovariectomy and ERalpha expression abolished the tumor growth-promoting effect of benzo[a]pyrene.	Benzo(a)pyrene	92-106	estrogen receptor 1	Homo sapiens	26-33
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-57
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	catechol-O-methyltransferase	Homo sapiens	90-94
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	estrogen receptor 1	Homo sapiens	112-119
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	estrogen receptor 1	Homo sapiens	260-267
21920623-9	2012	ERalpha inhibited AhR from up-regulating CYP1 in response to benzo[a]pyrene exposure, but it increased angiogenic VEGF-A expression with body estrogen levels.	Benzo(a)pyrene	61-75	estrogen receptor 1	Homo sapiens	0-7
21920623-9	2012	ERalpha inhibited AhR from up-regulating CYP1 in response to benzo[a]pyrene exposure, but it increased angiogenic VEGF-A expression with body estrogen levels.	Benzo(a)pyrene	61-75	aryl hydrocarbon receptor	Homo sapiens	18-21
21920623-9	2012	ERalpha inhibited AhR from up-regulating CYP1 in response to benzo[a]pyrene exposure, but it increased angiogenic VEGF-A expression with body estrogen levels.	Benzo(a)pyrene	61-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-45
22155171-8	2012	We demonstrate that FEN1 employs its GEN activity to cleave DNA bubble substrates with BP-induced lesions, but the E160D FEN1 mutation abolishes such activity.	Benzo(a)pyrene	87-89	flap structure specific endonuclease 1	Mus musculus	20-24
22155171-8	2012	We demonstrate that FEN1 employs its GEN activity to cleave DNA bubble substrates with BP-induced lesions, but the E160D FEN1 mutation abolishes such activity.	Benzo(a)pyrene	87-89	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	37-40
22174033-4	2012	Moreover, PEITC suppressed in concentration-dependent manner the benzo[a]pyrene-mediated rise in rat hepatic CYP1A1 mRNA levels in rat slices.	Benzo(a)pyrene	65-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	109-115
22114095-4	2012	Our data show that bp and pny inflorescence defects are caused by BOP1/2 gain of function in stems and pedicels.	Benzo(a)pyrene	19-21	Ankyrin repeat family protein / BTB/POZ domain-containing protein	Arabidopsis thaliana	66-70
22228805-6	2012	Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	96-99
22228805-6	2012	Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	141-144
22228805-6	2012	Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation.	Benzo(a)pyrene	16-19	aryl-hydrocarbon receptor	Mus musculus	96-99
22228805-6	2012	Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation.	Benzo(a)pyrene	16-19	aryl-hydrocarbon receptor	Mus musculus	141-144
22228805-7	2012	We tested the hypothesis that activation of the AHR of different signaling potencies by BaP would have differential effects on the physiology and pathology of the mouse cardiovascular system.	Benzo(a)pyrene	88-91	aryl-hydrocarbon receptor	Mus musculus	48-51
22228805-8	2012	We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta.	Benzo(a)pyrene	61-64	aryl-hydrocarbon receptor	Mus musculus	27-30
22228805-8	2012	We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta.	Benzo(a)pyrene	61-64	aryl-hydrocarbon receptor	Mus musculus	112-115
22228805-8	2012	We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta.	Benzo(a)pyrene	61-64	aryl-hydrocarbon receptor	Mus musculus	112-115
22227536-8	2012	Our results demonstrated that BaP could induce the malignant transformation of 16HBE cells, and p53 and p-Akt (Ser473) might play crucial roles in BaP-induced carcinogenesis.	Benzo(a)pyrene	147-150	tumor protein p53	Homo sapiens	96-99
22227536-9	2012	The five monoclonal cell lines (T-16HBE-C1~5) with different migration capabilities could be used as research models for further understanding the mechanisms of BaP-induced carcinogenesis and cell migration.	Benzo(a)pyrene	161-164	placenta associated 8	Homo sapiens	40-44
22253057-10	2012	Gclm-/- males exposed prenatally to BaP had greater decreases in testicular weights, testicular sperm head counts, epididymal sperm counts, and epididymal sperm motility than Gclm+/+ littermates.	Benzo(a)pyrene	36-39	glutamate-cysteine ligase, modifier subunit	Mus musculus	0-4
22253057-10	2012	Gclm-/- males exposed prenatally to BaP had greater decreases in testicular weights, testicular sperm head counts, epididymal sperm counts, and epididymal sperm motility than Gclm+/+ littermates.	Benzo(a)pyrene	36-39	glutamate-cysteine ligase, modifier subunit	Mus musculus	175-179
22611935-7	2012	The average percentage of methylated cytosines of p16 was higher in BP group than in controls (12.4%, 11.3%, respectively, P &gt; 0.05).	Benzo(a)pyrene	68-70	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
22155354-0	2012	Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells.	Benzo(a)pyrene	48-62	ATP binding cassette subfamily C member 4	Homo sapiens	0-36
22155354-4	2012	The AhR has particular importance in the lung and is most commonly associated with the up-regulation of cytochrome P-450 (CYP)-mediated metabolism of benzo[a]pyrene (B[a]P) to reactive intermediates.	Benzo(a)pyrene	150-164	aryl hydrocarbon receptor	Homo sapiens	4-7
22155354-4	2012	The AhR has particular importance in the lung and is most commonly associated with the up-regulation of cytochrome P-450 (CYP)-mediated metabolism of benzo[a]pyrene (B[a]P) to reactive intermediates.	Benzo(a)pyrene	150-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	104-120
22155354-4	2012	The AhR has particular importance in the lung and is most commonly associated with the up-regulation of cytochrome P-450 (CYP)-mediated metabolism of benzo[a]pyrene (B[a]P) to reactive intermediates.	Benzo(a)pyrene	150-164	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	122-125
22371409-5	2012	BP reduction was associated with a decrease in CRP concentration.	Benzo(a)pyrene	0-2	C-reactive protein	Homo sapiens	47-50
22120587-2	2012	Benzo[a]pyrene (BaP) is genotoxic and is a prototype of PAH carcinogens.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
22167199-0	2012	Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a beta2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.	Benzo(a)pyrene	66-80	adrenoceptor beta 2	Homo sapiens	92-117
22167199-0	2012	Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a beta2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.	Benzo(a)pyrene	66-80	Rap guanine nucleotide exchange factor 3	Homo sapiens	135-141
22167199-8	2012	Taken together, our results show that B(a)P binds directly to beta2ADR and consequently utilizes beta2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.	Benzo(a)pyrene	38-43	adrenoceptor beta 2	Homo sapiens	62-70
22167199-8	2012	Taken together, our results show that B(a)P binds directly to beta2ADR and consequently utilizes beta2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.	Benzo(a)pyrene	38-43	adrenoceptor beta 2	Homo sapiens	97-105
22167199-8	2012	Taken together, our results show that B(a)P binds directly to beta2ADR and consequently utilizes beta2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.	Benzo(a)pyrene	38-43	cathelicidin antimicrobial peptide	Homo sapiens	192-196
22167199-8	2012	Taken together, our results show that B(a)P binds directly to beta2ADR and consequently utilizes beta2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.	Benzo(a)pyrene	38-43	Rap guanine nucleotide exchange factor 3	Homo sapiens	197-203
22168545-12	2012	It also modified the activities of B(a)P metabolizing enzymes NADPH-cytochrome P450 reductase, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) in lung tissue of rats.	Benzo(a)pyrene	35-40	cytochrome p450 oxidoreductase	Rattus norvegicus	62-93
22168545-12	2012	It also modified the activities of B(a)P metabolizing enzymes NADPH-cytochrome P450 reductase, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) in lung tissue of rats.	Benzo(a)pyrene	35-40	epoxide hydrolase 1	Rattus norvegicus	95-123
22168545-12	2012	It also modified the activities of B(a)P metabolizing enzymes NADPH-cytochrome P450 reductase, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) in lung tissue of rats.	Benzo(a)pyrene	35-40	epoxide hydrolase 1, microsomal	Mus musculus	125-128
22168545-12	2012	It also modified the activities of B(a)P metabolizing enzymes NADPH-cytochrome P450 reductase, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) in lung tissue of rats.	Benzo(a)pyrene	35-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	135-160
22168545-12	2012	It also modified the activities of B(a)P metabolizing enzymes NADPH-cytochrome P450 reductase, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) in lung tissue of rats.	Benzo(a)pyrene	35-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	162-165
22135314-1	2012	Aldosterone and the mineralocorticoid receptor (MR) are critical to the maintenance of electrolyte and BP homeostasis.	Benzo(a)pyrene	103-105	nuclear receptor subfamily 3, group C, member 2	Mus musculus	20-46
22135314-1	2012	Aldosterone and the mineralocorticoid receptor (MR) are critical to the maintenance of electrolyte and BP homeostasis.	Benzo(a)pyrene	103-105	nuclear receptor subfamily 3, group C, member 2	Mus musculus	48-50
22140242-10	2012	The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.	Benzo(a)pyrene	117-119	homeobox protein ATH1	Arabidopsis thaliana	27-31
22140242-10	2012	The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.	Benzo(a)pyrene	117-119	homeobox knotted-like protein	Arabidopsis thaliana	32-37
22140242-10	2012	The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.	Benzo(a)pyrene	117-119	homeobox protein knotted-1-like 6	Arabidopsis thaliana	68-73
22048643-2	2012	To explore whether aberrant miRNAs expression can be used as biomarkers of chemical exposure in risk assessment of chemical carcinogenesis, we analyzed miRNA expression profiles of human bronchial epithelial cells expressing an oncogenic allele of H-Ras (HBER) at different stages of transformation induced by benzo(a)pyrene (BaP) by miRNA array.	Benzo(a)pyrene	310-324	HRas proto-oncogene, GTPase	Homo sapiens	248-253
22048643-2	2012	To explore whether aberrant miRNAs expression can be used as biomarkers of chemical exposure in risk assessment of chemical carcinogenesis, we analyzed miRNA expression profiles of human bronchial epithelial cells expressing an oncogenic allele of H-Ras (HBER) at different stages of transformation induced by benzo(a)pyrene (BaP) by miRNA array.	Benzo(a)pyrene	326-329	HRas proto-oncogene, GTPase	Homo sapiens	248-253
22048643-6	2012	However, the expression of miR-638 in HBER cells increased upon treatment of BaP in a dose-dependent manner.	Benzo(a)pyrene	77-80	microRNA 638	Homo sapiens	27-34
22048643-10	2012	Overexpression of miR-638 aggravated cell DNA damage induced by BaP, which might be mediated by suppression of breast cancer 1 (BRCA1), one of the target genes of miR-638.	Benzo(a)pyrene	64-67	microRNA 638	Homo sapiens	18-25
22048643-10	2012	Overexpression of miR-638 aggravated cell DNA damage induced by BaP, which might be mediated by suppression of breast cancer 1 (BRCA1), one of the target genes of miR-638.	Benzo(a)pyrene	64-67	BRCA1 DNA repair associated	Homo sapiens	111-126
22048643-10	2012	Overexpression of miR-638 aggravated cell DNA damage induced by BaP, which might be mediated by suppression of breast cancer 1 (BRCA1), one of the target genes of miR-638.	Benzo(a)pyrene	64-67	BRCA1 DNA repair associated	Homo sapiens	128-133
22048643-10	2012	Overexpression of miR-638 aggravated cell DNA damage induced by BaP, which might be mediated by suppression of breast cancer 1 (BRCA1), one of the target genes of miR-638.	Benzo(a)pyrene	64-67	microRNA 638	Homo sapiens	163-170
22048643-11	2012	In summary, we suggest that miR-638 is involved in the BaP-induced carcinogenesis by targeting BRCA1.	Benzo(a)pyrene	55-58	microRNA 638	Homo sapiens	28-35
22048643-11	2012	In summary, we suggest that miR-638 is involved in the BaP-induced carcinogenesis by targeting BRCA1.	Benzo(a)pyrene	55-58	BRCA1 DNA repair associated	Homo sapiens	95-100
22100782-0	2012	Identification of the couple GSK3alpha/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.	Benzo(a)pyrene	84-98	glycogen synthase kinase 3 alpha	Rattus norvegicus	29-38
22100782-0	2012	Identification of the couple GSK3alpha/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.	Benzo(a)pyrene	84-98	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	39-44
22100782-0	2012	Identification of the couple GSK3alpha/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.	Benzo(a)pyrene	84-98	hexokinase 2	Rattus norvegicus	67-80
22009068-3	2012	Firstly, we observed that in vitro exposure of D. polymorpha gill cells to benzo[a]pyrene (B[a]P, 98.4nM) induced an increase of the Olive Tail Moment (OTM) in both the comet-hOGG1 and comet-Fpg assays, indicating that B[a]P causes oxidative DNA damage.	Benzo(a)pyrene	75-89	8-oxoguanine DNA glycosylase	Homo sapiens	175-180
22009068-7	2012	These results show that the comet-hOGG1 assay detects oxidative DNA lesions induced in vitro by H2O2 and in vivo with BaP.	Benzo(a)pyrene	118-121	8-oxoguanine DNA glycosylase	Homo sapiens	34-39
22442665-4	2012	Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP).	Benzo(a)pyrene	123-137	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	31-37
21935598-0	2012	Development of single-chain variable fragment (scFv) antibodies against hapten benzo[a]pyrene: a binding study.	Benzo(a)pyrene	79-93	immunglobulin heavy chain variable region	Homo sapiens	47-51
22028397-4	2012	Using bisulfite sequencing, we examined the methylation status of p16(INK4alpha) promoter in peripheral blood lymphocytes (PBL) from PAH-exposed workers and in benzo(a)pyrene (BaP)-transformed human bronchial epithelial (HBE) cells.	Benzo(a)pyrene	176-179	cyclin dependent kinase inhibitor 2A	Homo sapiens	66-69
22028397-4	2012	Using bisulfite sequencing, we examined the methylation status of p16(INK4alpha) promoter in peripheral blood lymphocytes (PBL) from PAH-exposed workers and in benzo(a)pyrene (BaP)-transformed human bronchial epithelial (HBE) cells.	Benzo(a)pyrene	176-179	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-79
22028397-10	2012	Moreover, the hypermethylation and suppression of p16 expression was also found in BaP-transformed HBER cells.	Benzo(a)pyrene	83-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
22028404-1	2012	BACKGROUND: Benzo[a]pyrene (BaP) is one of the most potent carcinogens generated in cigarette smoke.	Benzo(a)pyrene	12-26	prohibitin 2	Homo sapiens	28-31
22415081-0	2012	Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice.	Benzo(a)pyrene	0-14	apolipoprotein E	Mus musculus	77-93
22785257-0	2012	Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats.	Benzo(a)pyrene	32-46	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	89-117
22785257-2	2012	Inhibition studies and kinetic analyses confirmed literature data indicating that methoxyresorufin is a specific CYP1A2 substrate in both uninduced and BaP-treated rats, whereas ethoxyresorufin is a specific CYP1A1 substrate only in BaP-treated rats.	Benzo(a)pyrene	152-155	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	113-119
23339006-10	2012	CONCLUSIONS: Determination of CgA, serotonin and 5HIAA may be useful in the diagnosis of BP NET, particularly in atypical carcinoid tumours, and their levels depend on the presence of distant metastases.	Benzo(a)pyrene	89-91	chromogranin A	Homo sapiens	30-33
21964900-0	2012	Hepatic mRNA, microRNA, and miR-34a-target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation.	Benzo(a)pyrene	96-110	microRNA 34a	Mus musculus	28-35
21964900-9	2012	In this study, we found a significant 2.0 and 3.6-fold increase following exposure to 50 and 75 mg/kg/day BaP, respectively, relative to controls for miR-34a.	Benzo(a)pyrene	106-109	microRNA 34a	Mus musculus	150-157
21556814-13	2012	Results suggest that PTT can be used for measuring absolute SBP when performing an individual correction for the offset of the BP-PWV relation.	Benzo(a)pyrene	61-63	selenium binding protein 1	Homo sapiens	21-24
22188915-5	2012	Under the stimulation of CCK after cholecystectomy, although the motion patterns of SO were similar to those before cholecystectomy, the greatest inhibitory efficacy of BP and PCA all decreased with the prolonged excitement duration and the increased percentage of retrograde contraction.	Benzo(a)pyrene	169-171	cholecystokinin	Canis lupus familiaris	25-28
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	49-52	tumor necrosis factor	Homo sapiens	0-27
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21912181-10	2012	CONCLUSION: The CC genotype of the EPO gene at position 3434 is more frequently found in patients with hypertension and is associated with higher BP levels.	Benzo(a)pyrene	146-148	erythropoietin	Homo sapiens	35-38
22442665-4	2012	Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP).	Benzo(a)pyrene	139-142	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	31-37
22442665-6	2012	After feeding of BaP for 21 days, only TLR2(-/-) mice, but not their wild type littermates developed polyps in the colon.	Benzo(a)pyrene	17-20	toll-like receptor 2	Mus musculus	39-43
22457794-4	2012	Knockdown of MUC1 expression significantly reduced transformation of immortalized human bronchial epithelial cells induced by benzo[a]pyrene diol epoxide (BPDE), the active form of the cigarette smoke (CS) carcinogen benzo(a)pyrene (BaP)s. BPDE exposure robustly activated a pathway consisting of EGFR, Akt and ERK, and blocking this pathway significantly increased BPDE-induced cell death and inhibited cell transformation.	Benzo(a)pyrene	217-231	mucin 1, cell surface associated	Homo sapiens	13-17
22319594-0	2012	Benzo[a]pyrene, aflatoxine B1 and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	70-74
22319594-6	2012	By using a functional assay, the Functional Analysis of Separated Alleles in Yeast (FASAY), the present study depicts the mutational pattern of TP53 in normal human fibroblasts after in vitro exposure to well-known carcinogens: benzo[a]pyrene, aflatoxin B(1) and acetaldehyde.	Benzo(a)pyrene	228-242	tumor protein p53	Homo sapiens	144-148
22457794-4	2012	Knockdown of MUC1 expression significantly reduced transformation of immortalized human bronchial epithelial cells induced by benzo[a]pyrene diol epoxide (BPDE), the active form of the cigarette smoke (CS) carcinogen benzo(a)pyrene (BaP)s. BPDE exposure robustly activated a pathway consisting of EGFR, Akt and ERK, and blocking this pathway significantly increased BPDE-induced cell death and inhibited cell transformation.	Benzo(a)pyrene	233-236	mucin 1, cell surface associated	Homo sapiens	13-17
22225155-1	2011	We report zero kinetic energy (ZEKE) photoelectron spectroscopy of benzo[a]pyrene (BaP) via resonantly enhanced multiphoton ionization (REMPI).	Benzo(a)pyrene	67-81	prohibitin 2	Homo sapiens	83-86
22044530-5	2011	TCDD suppressed 1-NP- but not BaP-induced p53 activity, and in contrast, pifithrin-alpha (PFT-alpha), a p53 inhibitor, suppressed both 1-NP- and BaP-induced p53 activity.	Benzo(a)pyrene	145-148	tumor protein p53	Homo sapiens	104-107
22044530-5	2011	TCDD suppressed 1-NP- but not BaP-induced p53 activity, and in contrast, pifithrin-alpha (PFT-alpha), a p53 inhibitor, suppressed both 1-NP- and BaP-induced p53 activity.	Benzo(a)pyrene	145-148	tumor protein p53	Homo sapiens	104-107
22202470-3	2011	Because some PAHs such as Benzo[a]pyrene (BaP) are proven carcinogens and mutagens, it is necessary to continuously monitor their concentrations in the air, water, and soil.	Benzo(a)pyrene	26-40	prohibitin 2	Homo sapiens	42-45
21803694-2	2011	OBJECTIVES: We conducted studies to evaluate the role of AHR polymorphisms in the disruption of renal developmental programming by benzo(a)pyrene (BaP).	Benzo(a)pyrene	131-145	aryl-hydrocarbon receptor	Mus musculus	57-60
21803694-2	2011	OBJECTIVES: We conducted studies to evaluate the role of AHR polymorphisms in the disruption of renal developmental programming by benzo(a)pyrene (BaP).	Benzo(a)pyrene	147-150	aryl-hydrocarbon receptor	Mus musculus	57-60
22052432-0	2011	Report on stage III Pig-a mutation assays using benzo[a]pyrene.	Benzo(a)pyrene	48-62	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	20-25
22052432-7	2011	BaP also produced significant increases in %MN-RET frequency at Days 4 and 29, with the responses being greater in F344 than Han Wistar rats.	Benzo(a)pyrene	0-3	ret proto-oncogene	Rattus norvegicus	47-50
22052432-9	2011	Finally, mutation assays performed on splenocytes from Day 56 F344 rats indicated that BaP mutant frequencies were three to fivefold higher for the Hprt gene than the Pig-a gene.	Benzo(a)pyrene	87-90	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	148-152
21393351-1	2011	Benzo(a)pyrene (BaP) has been shown to be an inducer of apoptosis.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
22021713-3	2011	After 14 days, AngII increased both BP and the numbers of CD3(+) and proliferating cells in the kidney.	Benzo(a)pyrene	36-38	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	15-20
22021713-7	2011	Taken together, these data suggest that ET(A) receptor activation in AngII-mediated hypertension increases CD3(+) cells and proliferation in the renal cortex independent of changes in BP, but changes in the number of inflammatory cells in the renal medulla are BP dependent.	Benzo(a)pyrene	261-263	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	69-74
21964300-5	2011	BaP exposure (40muM) produced AHR2-dependent bradycardia, pericardial edema, and myocardial CYP1A immunofluorescence.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor 2	Danio rerio	30-34
21964300-5	2011	BaP exposure (40muM) produced AHR2-dependent bradycardia, pericardial edema, and myocardial CYP1A immunofluorescence.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily A	Danio rerio	92-97
21911031-0	2011	Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcalphaRI by the environmental contaminant benzo(a)pyrene in human macrophages.	Benzo(a)pyrene	109-123	aryl hydrocarbon receptor	Homo sapiens	0-25
21911031-1	2011	Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	49-63	prohibitin 2	Homo sapiens	65-68
21911031-1	2011	Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	49-63	aryl hydrocarbon receptor	Homo sapiens	192-217
21911031-1	2011	Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	49-63	aryl hydrocarbon receptor	Homo sapiens	219-222
21911080-2	2011	However, the effect of BaP on mitochondria function and p73, and their possible roles in BaP-induced cell death have not been well studied.	Benzo(a)pyrene	23-26	tumor protein p73	Homo sapiens	56-59
21911080-3	2011	This study focused on mitochondria-mediated cell death and the occurrence of p73 protein accumulation in BaP-treated human hepatoma Hep3B (p53-null) cells.	Benzo(a)pyrene	105-108	tumor protein p73	Homo sapiens	77-80
21911080-3	2011	This study focused on mitochondria-mediated cell death and the occurrence of p73 protein accumulation in BaP-treated human hepatoma Hep3B (p53-null) cells.	Benzo(a)pyrene	105-108	tumor protein p53	Homo sapiens	139-142
21911080-4	2011	We found that BaP (8, 16, 32 and 64muM) induced early necrosis at 12h and delayed apoptosis at 24h.	Benzo(a)pyrene	14-17	latexin	Homo sapiens	35-38
21911080-8	2011	In addition, after BaP treatment, c-Jun N-terminal kinase (JNK) and Bax were activated during apoptosis and no change in p73 protein level was observed.	Benzo(a)pyrene	19-22	mitogen-activated protein kinase 8	Homo sapiens	34-57
21911080-8	2011	In addition, after BaP treatment, c-Jun N-terminal kinase (JNK) and Bax were activated during apoptosis and no change in p73 protein level was observed.	Benzo(a)pyrene	19-22	mitogen-activated protein kinase 8	Homo sapiens	59-62
21911080-8	2011	In addition, after BaP treatment, c-Jun N-terminal kinase (JNK) and Bax were activated during apoptosis and no change in p73 protein level was observed.	Benzo(a)pyrene	19-22	BCL2 associated X, apoptosis regulator	Homo sapiens	68-71
21911080-10	2011	Activation of JNK and Bax possibly contributed to BaP-induced apoptosis.	Benzo(a)pyrene	50-53	mitogen-activated protein kinase 8	Homo sapiens	14-17
21911080-10	2011	Activation of JNK and Bax possibly contributed to BaP-induced apoptosis.	Benzo(a)pyrene	50-53	BCL2 associated X, apoptosis regulator	Homo sapiens	22-25
21942922-0	2011	Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants.	Benzo(a)pyrene	118-132	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	28-42
21942922-9	2011	The steady accumulation of tissue DNA adducts in the implant groups corroborates the sustained overexpression of CYP1A1 and 1B1, the cytochrome P450s involved in the conversion of BP to its electrophilic metabolites.	Benzo(a)pyrene	180-182	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	113-127
21942922-10	2011	In contrast, the overexpression of CYP1A1 and 1B1 resulting from the bolus dose of BP lasted only for a few days.	Benzo(a)pyrene	83-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	35-49
21942922-12	2011	On the basis of our recent study in which we showed the presence of 17beta-estradiol in the lung, the sustained overexpression of CYP1A1 and 1B1 due to continuous exposure to BP may increase the susceptibility to estrogen-mediated carcinogenicity.	Benzo(a)pyrene	175-177	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	130-144
21839799-14	2011	Our results revealed a close link between behavioral changes and altered neurotransmitter receptor gene expression in BaP-treated rats.	Benzo(a)pyrene	118-121	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	73-98
21733121-5	2011	BaP treatment caused a significant increase in the levels of MDA and IL-6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione-S-transferase in the cervix and liver.	Benzo(a)pyrene	0-3	interleukin 6	Mus musculus	69-73
21733121-5	2011	BaP treatment caused a significant increase in the levels of MDA and IL-6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione-S-transferase in the cervix and liver.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	115-121
21733121-5	2011	BaP treatment caused a significant increase in the levels of MDA and IL-6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione-S-transferase in the cervix and liver.	Benzo(a)pyrene	0-3	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	143-169
21733121-5	2011	BaP treatment caused a significant increase in the levels of MDA and IL-6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione-S-transferase in the cervix and liver.	Benzo(a)pyrene	0-3	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	171-174
22017508-2	2011	Although CYP2E1 prefers small-size molecules for the substrates, the enzyme mediates oxidations of large-size molecules, such as benzo[a]pyrene.	Benzo(a)pyrene	129-143	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	9-15
21976233-0	2011	Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta  Mouse.	Benzo(a)pyrene	28-42	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	51-56
21976233-5	2011	BaP-derived DNA adducts were detected in all tissues examined and significant dose-dependent increases in mutant Pig-a phenotypes (i.e., RET(CD24-) and RBC (CD24-)) and lacZ mutants were observed.	Benzo(a)pyrene	0-3	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	113-118
21976233-5	2011	BaP-derived DNA adducts were detected in all tissues examined and significant dose-dependent increases in mutant Pig-a phenotypes (i.e., RET(CD24-) and RBC (CD24-)) and lacZ mutants were observed.	Benzo(a)pyrene	0-3	RET	Sus scrofa	137-140
22017508-4	2011	The region, having a benzo[a]pyrene-like shape, was thus used as a CYP2E1 template.	Benzo(a)pyrene	21-35	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	67-73
22357517-0	2011	[Effects of benzo(a)pyrene on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins in rat brain tissue].	Benzo(a)pyrene	12-26	BCL2, apoptosis regulator	Rattus norvegicus	76-81
21827816-1	2011	The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice.	Benzo(a)pyrene	134-148	prohibitin 2	Mus musculus	150-153
22357513-0	2011	[Effects of DNA polymerase beta on the genotoxicity and genetic instability induced by benzo(a)pyrene].	Benzo(a)pyrene	87-101	DNA polymerase beta	Homo sapiens	12-31
22357513-1	2011	OBJECTIVE: To explore the effects of DNA polymerase beta expression level on the genotoxicity and genetic instability induced by benzo(a)pyrene (BaP),and provide experimental the basis for further study on the carcinogenic molecular mechanism of BaP.	Benzo(a)pyrene	129-143	DNA polymerase beta	Homo sapiens	37-56
22357513-1	2011	OBJECTIVE: To explore the effects of DNA polymerase beta expression level on the genotoxicity and genetic instability induced by benzo(a)pyrene (BaP),and provide experimental the basis for further study on the carcinogenic molecular mechanism of BaP.	Benzo(a)pyrene	129-143	prohibitin 2	Homo sapiens	145-148
22357513-1	2011	OBJECTIVE: To explore the effects of DNA polymerase beta expression level on the genotoxicity and genetic instability induced by benzo(a)pyrene (BaP),and provide experimental the basis for further study on the carcinogenic molecular mechanism of BaP.	Benzo(a)pyrene	129-143	prohibitin 2	Homo sapiens	246-249
21872649-2	2011	We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect.	Benzo(a)pyrene	39-53	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-133
21872649-2	2011	We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect.	Benzo(a)pyrene	55-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-133
21802500-4	2011	Our data indicated that the impacts of BaP and TCDD on transcriptome of LNCaP cells significantly overlap, since over 64% of significantly up-regulated genes and 47% of down-regulated genes were similarly affected by both AhR ligands.	Benzo(a)pyrene	39-42	aryl hydrocarbon receptor	Homo sapiens	222-225
21802500-5	2011	This suggested that the activation of AhR played a prominent role in the nongenotoxic effects of BaP in the prostate carcinoma cell model LNCaP.	Benzo(a)pyrene	97-100	aryl hydrocarbon receptor	Homo sapiens	38-41
22357517-0	2011	[Effects of benzo(a)pyrene on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins in rat brain tissue].	Benzo(a)pyrene	12-26	BCL2 associated X, apoptosis regulator	Rattus norvegicus	86-89
22357517-1	2011	OBJECTIVE: To observe the effects of Benzo(a)pyrene (BaP) on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins and to explore the mechanism of neurotoxicity induced by BaP in rats.	Benzo(a)pyrene	37-51	prohibitin 2	Rattus norvegicus	53-56
22357517-1	2011	OBJECTIVE: To observe the effects of Benzo(a)pyrene (BaP) on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins and to explore the mechanism of neurotoxicity induced by BaP in rats.	Benzo(a)pyrene	37-51	BCL2, apoptosis regulator	Rattus norvegicus	107-112
22357517-1	2011	OBJECTIVE: To observe the effects of Benzo(a)pyrene (BaP) on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins and to explore the mechanism of neurotoxicity induced by BaP in rats.	Benzo(a)pyrene	37-51	BCL2 associated X, apoptosis regulator	Rattus norvegicus	117-120
21742781-7	2011	Under coculture conditions, the prohaptens eugenol, 2-methoxy-4-methylphenol, and benzo[a]pyrene induced a significantly higher upregulation of CD86 expression on THP-1.	Benzo(a)pyrene	82-96	CD86 molecule	Homo sapiens	144-148
21720915-7	2011	Results obtained showed that HE/HP-beta-CyD was also able to reduce BaP-induced AhR and CYP1A1 protein expression (p&lt;0.001).	Benzo(a)pyrene	68-71	aryl hydrocarbon receptor	Homo sapiens	80-83
21720915-7	2011	Results obtained showed that HE/HP-beta-CyD was also able to reduce BaP-induced AhR and CYP1A1 protein expression (p&lt;0.001).	Benzo(a)pyrene	68-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
21742781-7	2011	Under coculture conditions, the prohaptens eugenol, 2-methoxy-4-methylphenol, and benzo[a]pyrene induced a significantly higher upregulation of CD86 expression on THP-1.	Benzo(a)pyrene	82-96	GLI family zinc finger 2	Homo sapiens	163-168
21897389-6	2011	RESULTS: The risk of RCC increased with intake of barbecued meat (P(trend)=0.04) and the PAH, benzo(a)pyrene (BaP) (multivariable-adjusted odds ratio and 95% confidence interval, highest vs lowest quartile: 1.50 (1.14, 1.95), P(trend)=0.001).	Benzo(a)pyrene	94-108	prohibitin 2	Homo sapiens	110-113
21745588-0	2011	A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage.	Benzo(a)pyrene	20-34	transformation related protein 53, pseudogene	Mus musculus	42-45
21745588-3	2011	The present study detected DNA damage and the expression of the p53 gene in BaP-induced cervical tissue in female mice.	Benzo(a)pyrene	76-79	transformation related protein 53, pseudogene	Mus musculus	64-67
21745588-9	2011	The results demonstrate that BaP may show toxic effect on the cervix by increasing DNA damage and the expression of the p53 gene.	Benzo(a)pyrene	29-32	transformation related protein 53, pseudogene	Mus musculus	120-123
21809831-5	2011	Previously, we demonstrated that benzophenone-2, benzophenone, perfluorooctane sulfonate, bisphenol A bis ether, and vinclozolin decreased TPO activity, and that dibutyl phthalate, carbaryl, dibenzo(a,h)anthracene, benzo(a)pyrene, and methylmercury increased TPO activity.	Benzo(a)pyrene	215-229	thyroid peroxidase	Homo sapiens	139-142
21601985-0	2011	Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathways in female mice.	Benzo(a)pyrene	18-32	caspase 3	Mus musculus	119-128
21633290-3	2011	BP treatment resulted in a significant decrease in the zinc levels and protein expression of p21.	Benzo(a)pyrene	0-2	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	93-96
21633290-4	2011	On the contrary, the enzyme activity of cox-2 showed a significant increase in the BP-treated mice.	Benzo(a)pyrene	83-85	prostaglandin-endoperoxide synthase 2	Mus musculus	40-45
21633290-5	2011	Interestingly, combined supplementation of curcumin and resveratrol to BP-treated mice resulted in an appreciable improvement in the zinc levels and protein expression of p21.	Benzo(a)pyrene	71-73	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	171-174
21633290-6	2011	In contrast, synergistic supplementation with phytochemicals resulted in a significant decrease in the enzyme activities of cox-2 in BP-treated mice.	Benzo(a)pyrene	133-135	prostaglandin-endoperoxide synthase 2	Mus musculus	124-129
22977576-8	2011	In conclusion, most of the BP-NETs examined in this study expressed p-AKT and p-mTOR, suggesting that the AKT/mTOR pathway plays an important role in these tumors.	Benzo(a)pyrene	27-29	AKT serine/threonine kinase 1	Homo sapiens	70-73
22977576-8	2011	In conclusion, most of the BP-NETs examined in this study expressed p-AKT and p-mTOR, suggesting that the AKT/mTOR pathway plays an important role in these tumors.	Benzo(a)pyrene	27-29	mechanistic target of rapamycin kinase	Homo sapiens	80-84
22977576-8	2011	In conclusion, most of the BP-NETs examined in this study expressed p-AKT and p-mTOR, suggesting that the AKT/mTOR pathway plays an important role in these tumors.	Benzo(a)pyrene	27-29	AKT serine/threonine kinase 1	Homo sapiens	106-109
22977576-8	2011	In conclusion, most of the BP-NETs examined in this study expressed p-AKT and p-mTOR, suggesting that the AKT/mTOR pathway plays an important role in these tumors.	Benzo(a)pyrene	27-29	mechanistic target of rapamycin kinase	Homo sapiens	110-114
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	180-182	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	180-182	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	190-192	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	190-192	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	190-192	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	190-192	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43
21669939-8	2011	Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation.	Benzo(a)pyrene	70-72	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	144-150
21669939-8	2011	Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation.	Benzo(a)pyrene	70-72	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	155-161
21569818-1	2011	Exposure to the environmental mutagen benzo(a)pyrene (BaP) alters the expression of AHR-responsive genes as well as genes involved in other pathways.	Benzo(a)pyrene	38-52	aryl-hydrocarbon receptor	Mus musculus	84-87
21715664-0	2011	Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.	Benzo(a)pyrene	132-146	xeroderma pigmentosum, complementation group A	Mus musculus	97-100
21715664-0	2011	Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.	Benzo(a)pyrene	132-146	transformation related protein 53, pseudogene	Mus musculus	103-106
21550168-3	2011	In addition, the synthetic miR-143/BP induced apoptotic cell death in some of the transfected cells.	Benzo(a)pyrene	35-37	microRNA 143	Homo sapiens	27-34
21401886-1	2011	In this study, we investigated the role of nuclear respiratory factor-1(NRF-1) in benzo(a)pyrene (BaP)-induced mitochondrial events in human bronchial epithelial cells (16HBE).	Benzo(a)pyrene	98-101	nuclear respiratory factor 1	Homo sapiens	43-71
21401886-1	2011	In this study, we investigated the role of nuclear respiratory factor-1(NRF-1) in benzo(a)pyrene (BaP)-induced mitochondrial events in human bronchial epithelial cells (16HBE).	Benzo(a)pyrene	98-101	nuclear respiratory factor 1	Homo sapiens	72-77
21401886-6	2011	Results of western blotting assay revealed that both NRF-1 and mitochondrial transcription factor A (mtTFA) decreased in 12-muM BaP-treated cells at both 12 and 24 hr.	Benzo(a)pyrene	128-131	nuclear respiratory factor 1	Homo sapiens	53-58
21401886-6	2011	Results of western blotting assay revealed that both NRF-1 and mitochondrial transcription factor A (mtTFA) decreased in 12-muM BaP-treated cells at both 12 and 24 hr.	Benzo(a)pyrene	128-131	transcription factor A, mitochondrial	Homo sapiens	63-99
21401886-6	2011	Results of western blotting assay revealed that both NRF-1 and mitochondrial transcription factor A (mtTFA) decreased in 12-muM BaP-treated cells at both 12 and 24 hr.	Benzo(a)pyrene	128-131	transcription factor A, mitochondrial	Homo sapiens	101-106
21401886-8	2011	Down-regulation of NRF-1 by shRNA further reduced the loss of MPT and increased ROS generation in response to BaP treatment.	Benzo(a)pyrene	110-113	nuclear respiratory factor 1	Homo sapiens	19-24
21401886-9	2011	Therefore, our results demonstrate that NRF-1 is responsible for BaP-induced mitochondrial dysfunction in 16HBE cells and associated with the level of mtTFA protein, loss of MPT and ROS overproduction.	Benzo(a)pyrene	65-68	nuclear respiratory factor 1	Homo sapiens	40-45
21401886-9	2011	Therefore, our results demonstrate that NRF-1 is responsible for BaP-induced mitochondrial dysfunction in 16HBE cells and associated with the level of mtTFA protein, loss of MPT and ROS overproduction.	Benzo(a)pyrene	65-68	transcription factor A, mitochondrial	Homo sapiens	151-156
22108330-1	2011	OBJECTIVE: The present study aimed to test whether exposure to benzo(a)pyrene [B(a)P] affects spatial learning and short-term memory by modulating the expression of the Gria1 and Grin2a glutamate receptor subunit genes in the hippocampus.	Benzo(a)pyrene	63-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
22108330-1	2011	OBJECTIVE: The present study aimed to test whether exposure to benzo(a)pyrene [B(a)P] affects spatial learning and short-term memory by modulating the expression of the Gria1 and Grin2a glutamate receptor subunit genes in the hippocampus.	Benzo(a)pyrene	63-77	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	179-185
22108330-1	2011	OBJECTIVE: The present study aimed to test whether exposure to benzo(a)pyrene [B(a)P] affects spatial learning and short-term memory by modulating the expression of the Gria1 and Grin2a glutamate receptor subunit genes in the hippocampus.	Benzo(a)pyrene	79-84	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
22108330-1	2011	OBJECTIVE: The present study aimed to test whether exposure to benzo(a)pyrene [B(a)P] affects spatial learning and short-term memory by modulating the expression of the Gria1 and Grin2a glutamate receptor subunit genes in the hippocampus.	Benzo(a)pyrene	79-84	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	179-185
21522162-1	2011	Dopamine D(2) receptor occupancy of antipsychotic drugs is calculated relative to the subject"s D(2) receptor binding potential (BP) in the drug-free state (baseline BP).	Benzo(a)pyrene	129-131	dopamine receptor D2	Homo sapiens	0-22
21457773-2	2011	The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed.	Benzo(a)pyrene	18-32	tumor protein p53	Homo sapiens	136-139
21457773-2	2011	The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed.	Benzo(a)pyrene	18-32	tumor protein p53	Homo sapiens	195-198
21457773-2	2011	The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed.	Benzo(a)pyrene	34-36	tumor protein p53	Homo sapiens	136-139
21457773-2	2011	The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed.	Benzo(a)pyrene	34-36	tumor protein p53	Homo sapiens	195-198
21457773-5	2011	After BP-treatment the strongest p53 protein induction and phosphorylation at serine 392 was found in ZR-75-1 cells with a wt TP53 gene.	Benzo(a)pyrene	6-8	tumor protein p53	Homo sapiens	33-36
21457773-5	2011	After BP-treatment the strongest p53 protein induction and phosphorylation at serine 392 was found in ZR-75-1 cells with a wt TP53 gene.	Benzo(a)pyrene	6-8	tumor protein p53	Homo sapiens	126-130
21569818-1	2011	Exposure to the environmental mutagen benzo(a)pyrene (BaP) alters the expression of AHR-responsive genes as well as genes involved in other pathways.	Benzo(a)pyrene	54-57	aryl-hydrocarbon receptor	Mus musculus	84-87
21675704-4	2011	Exposure of BEAS-2B and HBE to BaP caused epithelial cells to produce inflammatory cytokines IL-8, which subsequently induced BSMC proliferation and migration.	Benzo(a)pyrene	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
21645723-1	2011	Benzo[a]pyrene (BaP), a member of the polycyclic aromatic hydrocarbon (PAH) class, is one of the most potent PAH carcinogens.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
21594244-7	2011	Then the above proposed baseline-correction method was applied to the determination of benzo(a)pyrene (BaP) in vegetable oil samples by second-derivative synchronous fluorescence spectroscopy.	Benzo(a)pyrene	87-101	prohibitin 2	Homo sapiens	103-106
21836897-4	2011	A distorted octahedral coordination geometry of the Co(II) atom results from ligation of an H atom, which is part of an agostic B-H Co inter-action [H Co = 2.12 (3) A], and by five imine N atoms, two from a Bp ligand and three from a Tp ligand.	Benzo(a)pyrene	207-209	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-58
21569840-2	2011	NAD(P)H:quinone oxidoreductase-1 (NQO1) is an enzyme that catalyzes BaP-quinone detoxification.	Benzo(a)pyrene	68-71	NAD(P)H dehydrogenase, quinone 1	Mus musculus	0-32
21569840-8	2011	Our data also showed that the basal level of AhR and the BaP-induced level of Nrf2 were significantly higher in hCatTg MAECs than in wild-type cells.	Benzo(a)pyrene	57-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
21834273-6	2011	RESULTS: We estimated that PAH exposure as measured by benzo[a]pyrene (BaP) can explain a significant part of the excess risk but not fully (Odd Ratio (OR)   3 as compared to an observed OR = 8 for smoky coal users versus smokeless coal users).	Benzo(a)pyrene	55-69	phenylalanine hydroxylase	Homo sapiens	27-30
21834273-6	2011	RESULTS: We estimated that PAH exposure as measured by benzo[a]pyrene (BaP) can explain a significant part of the excess risk but not fully (Odd Ratio (OR)   3 as compared to an observed OR = 8 for smoky coal users versus smokeless coal users).	Benzo(a)pyrene	55-69	prohibitin 2	Homo sapiens	71-74
21569840-2	2011	NAD(P)H:quinone oxidoreductase-1 (NQO1) is an enzyme that catalyzes BaP-quinone detoxification.	Benzo(a)pyrene	68-71	NAD(P)H dehydrogenase, quinone 1	Mus musculus	34-38
21569840-6	2011	BaP treatment increased NQO1 mRNA and protein levels in both groups, with a significantly greater induction in hCatTg MAECs than in wild-type cells.	Benzo(a)pyrene	0-3	NAD(P)H dehydrogenase, quinone 1	Mus musculus	24-28
21569840-7	2011	BaP-induced NQO1 promoter activity was dramatically higher in hCatTg MAECs than in wild-type cells.	Benzo(a)pyrene	0-3	NAD(P)H dehydrogenase, quinone 1	Mus musculus	12-16
21569840-10	2011	Knockdown of AhR by RNA interference diminished BaP-induced expression of Nrf2 and NQO1.	Benzo(a)pyrene	48-51	aryl-hydrocarbon receptor	Mus musculus	13-16
21569840-10	2011	Knockdown of AhR by RNA interference diminished BaP-induced expression of Nrf2 and NQO1.	Benzo(a)pyrene	48-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
21569840-10	2011	Knockdown of AhR by RNA interference diminished BaP-induced expression of Nrf2 and NQO1.	Benzo(a)pyrene	48-51	NAD(P)H dehydrogenase, quinone 1	Mus musculus	83-87
21569840-11	2011	Knockdown of Nrf2 significantly decreased NQO1 mRNA and protein levels in cells with or without BaP treatment.	Benzo(a)pyrene	96-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
21569840-11	2011	Knockdown of Nrf2 significantly decreased NQO1 mRNA and protein levels in cells with or without BaP treatment.	Benzo(a)pyrene	96-99	NAD(P)H dehydrogenase, quinone 1	Mus musculus	42-46
21569840-14	2011	These results suggest that catalase overexpression upregulates BaP-induced NQO1 expression by enhancing the Sp1-AhR-Nrf2 signaling cascade.	Benzo(a)pyrene	63-66	NAD(P)H dehydrogenase, quinone 1	Mus musculus	75-79
21569840-14	2011	These results suggest that catalase overexpression upregulates BaP-induced NQO1 expression by enhancing the Sp1-AhR-Nrf2 signaling cascade.	Benzo(a)pyrene	63-66	aryl-hydrocarbon receptor	Mus musculus	112-115
21569840-14	2011	These results suggest that catalase overexpression upregulates BaP-induced NQO1 expression by enhancing the Sp1-AhR-Nrf2 signaling cascade.	Benzo(a)pyrene	63-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
21507987-2	2011	Pulse-chase experiments showed that the increase in BaP-induced DNA adducts in BRCA1 knockdown cells may not be associated with BRCA1"s function in nucleotide excision repair activity; rather, it may be associated with its function in modulating transcriptional regulation.	Benzo(a)pyrene	52-55	BRCA1 DNA repair associated	Homo sapiens	79-84
21507987-1	2011	Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP).	Benzo(a)pyrene	85-99	BRCA1 DNA repair associated	Homo sapiens	23-28
21507987-1	2011	Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP).	Benzo(a)pyrene	101-104	BRCA1 DNA repair associated	Homo sapiens	23-28
21861342-0	2011	[Effect of benzo [a] pyrene on HSP70 expression in rat cortical neurons in vitro].	Benzo(a)pyrene	11-27	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	31-36
21861342-1	2011	OBJECTIVE: To explore the effect of benzo [a] pyrene (B [a] P) on heat shock protein 70 (HSP70) expression in rat cortical neurons in vitro.	Benzo(a)pyrene	36-52	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	66-87
21861342-1	2011	OBJECTIVE: To explore the effect of benzo [a] pyrene (B [a] P) on heat shock protein 70 (HSP70) expression in rat cortical neurons in vitro.	Benzo(a)pyrene	36-52	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	89-94
21861342-13	2011	CONCLUSION: High doses of metabolites of B [ a] P (0.5 - 10 micromol/L) inhibit the expression of HSP70 in cultured cortical neurons in rat, and there were relationships of dose and time-dependent between the dose and the inhibition.	Benzo(a)pyrene	41-49	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	98-103
21339737-2	2011	To explore the role of alpha4 in human cell transformation and tumorigenesis, we show that alpha4 is highly expressed in human cells transformed by chemical carcinogens including benzo(a)pyrene, aflatoxin B(1), N-methyl-N"-nitro-N-nitrosoguanidine, nickel sulfate and in several hepatic and lung cancer cell lines.	Benzo(a)pyrene	179-193	immunoglobulin binding protein 1	Homo sapiens	91-97
21714911-8	2011	Gene ontology and pathway analysis showed the involvement of various signalling pathways in response to BaP exposure, such as the Catenin/Wnt pathway in G1, the ERK pathway in G1 and S, the Nrf2 pathway in S and G2/M and the Akt pathway in G2/M.	Benzo(a)pyrene	104-107	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
21714911-8	2011	Gene ontology and pathway analysis showed the involvement of various signalling pathways in response to BaP exposure, such as the Catenin/Wnt pathway in G1, the ERK pathway in G1 and S, the Nrf2 pathway in S and G2/M and the Akt pathway in G2/M.	Benzo(a)pyrene	104-107	AKT serine/threonine kinase 1	Homo sapiens	225-228
20188852-1	2011	Benzo(a)pyrene (BaP) is a mutagenic and carcinogenic environmental contaminant.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
21453744-5	2011	Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol.	Benzo(a)pyrene	5-21	aryl hydrocarbon receptor	Homo sapiens	44-47
21453744-5	2011	Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol.	Benzo(a)pyrene	5-21	solute carrier family 25 member 5	Homo sapiens	56-59
21453744-5	2011	Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol.	Benzo(a)pyrene	5-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-86
21453744-5	2011	Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol.	Benzo(a)pyrene	5-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
21414625-9	2011	Increased CRP levels were an independent predictor of both abnormal FMD and IMT after adjusting for age, systolic and diastolic BP and total cholesterol.	Benzo(a)pyrene	128-130	C-reactive protein	Homo sapiens	10-13
21632310-5	2011	Benzo[b]fluoranthene, dibenz[a,h]anthracene, benzo[a]pyrene, and dibenzo[a,l]pyrene were the most carcinogenic PAH species evaluated.	Benzo(a)pyrene	45-59	phenylalanine hydroxylase	Homo sapiens	111-114
21507987-3	2011	BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent.	Benzo(a)pyrene	92-95	BRCA1 DNA repair associated	Homo sapiens	0-5
21507987-3	2011	BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent.	Benzo(a)pyrene	92-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	75-81
21507987-3	2011	BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent.	Benzo(a)pyrene	138-141	BRCA1 DNA repair associated	Homo sapiens	0-5
21507987-3	2011	BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent.	Benzo(a)pyrene	138-141	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	75-81
21507987-3	2011	BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent.	Benzo(a)pyrene	138-141	BRCA1 DNA repair associated	Homo sapiens	161-166
21507987-4	2011	However, our study shows that BRCA1 defective cells may still be able to biotransform BaP by regulating other CYP enzymes, including CYP1B1.	Benzo(a)pyrene	86-89	BRCA1 DNA repair associated	Homo sapiens	30-35
21507987-4	2011	However, our study shows that BRCA1 defective cells may still be able to biotransform BaP by regulating other CYP enzymes, including CYP1B1.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	133-139
21507987-7	2011	Thus, we concluded that the increased amount of BaP-induced DNA adducts in BRCA1 knockdown cells is strongly associated with its loss of functional detoxification.	Benzo(a)pyrene	48-51	BRCA1 DNA repair associated	Homo sapiens	75-80
21507987-9	2011	Regulation of UGT1A1 and UGT1A9 expression showed that the induction of DNA adducts by BaP is directly affected by their expression levels.	Benzo(a)pyrene	87-90	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-20
21507987-9	2011	Regulation of UGT1A1 and UGT1A9 expression showed that the induction of DNA adducts by BaP is directly affected by their expression levels.	Benzo(a)pyrene	87-90	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	25-31
21507987-10	2011	Finally, overexpression of UGTs, NRF2, or ARNT significantly decreased the amount of BaP-induced adducts in BRCA1-deficient cells.	Benzo(a)pyrene	85-88	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
21507987-10	2011	Finally, overexpression of UGTs, NRF2, or ARNT significantly decreased the amount of BaP-induced adducts in BRCA1-deficient cells.	Benzo(a)pyrene	85-88	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	42-46
21507987-11	2011	Overall, our results suggest that BRCA1 protects cells by reducing the amount of BaP-induced DNA adducts possibly via transcriptional activation of detoxification gene expression.	Benzo(a)pyrene	81-84	BRCA1 DNA repair associated	Homo sapiens	34-39
21461945-3	2011	We observed the localization of Bp in mice following oral administration, showing that Bp was surrounded by CD11c(+) cells in Peyer"s patches (PP) and cecal patches (CP).	Benzo(a)pyrene	32-34	integrin subunit alpha X	Homo sapiens	108-113
21546577-7	2011	Taken together, these data identify Af17 as a potential locus for the maintenance of sodium and BP homeostasis and suggest that a particular histone modification is directly linked to these processes.	Benzo(a)pyrene	96-98	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6	Mus musculus	36-40
21546577-8	2011	Af17-mediated regulation of BP is largely, but not exclusively, the result of modulating ENaC, suggesting it has potential as a therapeutic target for the control of BP.	Benzo(a)pyrene	28-30	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6	Mus musculus	0-4
21546577-8	2011	Af17-mediated regulation of BP is largely, but not exclusively, the result of modulating ENaC, suggesting it has potential as a therapeutic target for the control of BP.	Benzo(a)pyrene	28-30	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	89-93
21461945-4	2011	These results indicated that Bp might induce CD11c(+) cell-mediated immune responses directly.	Benzo(a)pyrene	29-31	integrin subunit alpha X	Homo sapiens	45-50
21461945-6	2011	Production of IL-10 and IL-12p40 by bone marrow-derived dendritic cells (BMDC) was significantly increased by Bp stimulation.	Benzo(a)pyrene	110-112	interleukin 10	Homo sapiens	14-19
21461945-7	2011	These results suggest that oral administration of Bp induces immune responses directly following capture by CD11c(+) dendritic cells (DCs).	Benzo(a)pyrene	50-52	integrin subunit alpha X	Homo sapiens	108-113
21787717-3	2011	Our data showed that GAT significantly decreased levels of ALT and AST in serum and the liver histological injury in BaP-treated mice.	Benzo(a)pyrene	117-120	glutamic pyruvic transaminase, soluble	Mus musculus	59-62
21787717-3	2011	Our data showed that GAT significantly decreased levels of ALT and AST in serum and the liver histological injury in BaP-treated mice.	Benzo(a)pyrene	117-120	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	67-70
21787717-5	2011	Furthermore, GAT markedly inhibited the BaP-induced increase of Cu/Zn-SOD, CAT, GPx and GST activities in the mouse liver.	Benzo(a)pyrene	40-43	superoxide dismutase 1, soluble	Mus musculus	64-73
21787717-5	2011	Furthermore, GAT markedly inhibited the BaP-induced increase of Cu/Zn-SOD, CAT, GPx and GST activities in the mouse liver.	Benzo(a)pyrene	40-43	catalase	Mus musculus	75-78
21787717-5	2011	Furthermore, GAT markedly inhibited the BaP-induced increase of Cu/Zn-SOD, CAT, GPx and GST activities in the mouse liver.	Benzo(a)pyrene	40-43	peroxiredoxin 6 pseudogene 2	Mus musculus	80-83
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	179-193	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
21367897-0	2011	Treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the Erk1/2 signaling pathway.	Benzo(a)pyrene	69-83	mitogen-activated protein kinase 3	Homo sapiens	132-138
21367897-6	2011	Here, we show that BaP treatment activates the Ras-Raf-Mek1/2-Erk1/2 signaling pathway.	Benzo(a)pyrene	19-22	zinc fingers and homeoboxes 2	Homo sapiens	51-54
21367897-6	2011	Here, we show that BaP treatment activates the Ras-Raf-Mek1/2-Erk1/2 signaling pathway.	Benzo(a)pyrene	19-22	mitogen-activated protein kinase kinase 1	Homo sapiens	55-61
21367897-6	2011	Here, we show that BaP treatment activates the Ras-Raf-Mek1/2-Erk1/2 signaling pathway.	Benzo(a)pyrene	19-22	mitogen-activated protein kinase 3	Homo sapiens	62-68
21367897-7	2011	The importance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition with multiple Erk1/2 pathway inhibitors.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 3	Homo sapiens	18-24
21367897-7	2011	The importance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition with multiple Erk1/2 pathway inhibitors.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 1	Homo sapiens	18-21
21367897-7	2011	The importance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition with multiple Erk1/2 pathway inhibitors.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 3	Homo sapiens	143-149
21367897-8	2011	Finally, BaP treatment activated p90RSK and its downstream target CDK1.	Benzo(a)pyrene	9-12	ribosomal protein S6 kinase A1	Homo sapiens	33-39
21367897-8	2011	Finally, BaP treatment activated p90RSK and its downstream target CDK1.	Benzo(a)pyrene	9-12	cyclin dependent kinase 1	Homo sapiens	66-70
21367897-9	2011	These data indicate that the Erk1/2 signaling pathway plays an important role in mediating the response to BaP treatment that ultimately leads to increased viral titers.	Benzo(a)pyrene	107-110	mitogen-activated protein kinase 3	Homo sapiens	29-35
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	179-193	aryl hydrocarbon receptor	Homo sapiens	144-169
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	179-193	aryl hydrocarbon receptor	Homo sapiens	171-174
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	179-193	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	247-253
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	195-198	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	195-198	aryl hydrocarbon receptor	Homo sapiens	144-169
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	195-198	aryl hydrocarbon receptor	Homo sapiens	171-174
21292640-2	2011	Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription.	Benzo(a)pyrene	195-198	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	247-253
21376747-7	2011	Lymphocyte proliferative responses to BaP, COx and PCM were significantly abrogated by 36.4%, 45.2% and 50.8%, respectively; in Cpr(low/low) knock out (KO) mice versus WT mice; while the lymphocyte proliferative responses to the direct acting haptens OX, EtOX and NABQI were comparable.	Benzo(a)pyrene	38-41	cytochrome p450 oxidoreductase	Mus musculus	128-131
21373662-0	2011	Changes in the optical properties of benzo[a]pyrene-coated aerosols upon heterogeneous reactions with NO2 and NO3.	Benzo(a)pyrene	37-51	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
21373662-3	2011	To study this potentially important process, the change in optical properties of laboratory-generated benzo[a]pyrene (BaP)-coated aerosols following exposure to NO(2) and NO(3) was investigated at 355 nm and 532 nm by three aerosol analysis techniques.	Benzo(a)pyrene	102-116	prohibitin 2	Homo sapiens	118-121
21115616-3	2011	Mice homozygous for this genetic modification (ACE 9/9 mice) had low BP levels, impaired ability to concentrate urine, and variable medullary thinning.	Benzo(a)pyrene	69-71	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	47-50
20848083-2	2011	BaP toxicity is mediated, in part, by activation of the aryl hydrocarbon receptor and formation of reactive metabolites, both of which lead to increased oxidative stress.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Rattus norvegicus	56-81
21130824-9	2011	Together, these results suggest that the protective effect of GJ against the genotoxicity of BaP may be related to the inhibition of Cyp1a1 enzyme activity.	Benzo(a)pyrene	93-96	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	133-139
21316925-0	2011	An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway.	Benzo(a)pyrene	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	80-93
21316925-0	2011	An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway.	Benzo(a)pyrene	30-44	aryl hydrocarbon receptor	Homo sapiens	136-161
21316925-1	2011	BACKGROUND: Benzo(a)pyrene (BaP) is an environmental contaminant found in cigarette smoke.	Benzo(a)pyrene	12-26	prohibitin 2	Homo sapiens	28-31
21252291-0	2011	Acute disruption of bone marrow hematopoiesis by benzo(a)pyrene is selectively reversed by aryl hydrocarbon receptor-mediated processes.	Benzo(a)pyrene	49-63	aryl-hydrocarbon receptor	Mus musculus	91-116
21252291-7	2011	AhR, therefore, mediates this BP recovery in each progenitor type.	Benzo(a)pyrene	30-32	aryl-hydrocarbon receptor	Mus musculus	0-3
21256954-0	2011	Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.	Benzo(a)pyrene	32-46	aryl hydrocarbon receptor	Homo sapiens	69-72
21256954-0	2011	Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.	Benzo(a)pyrene	32-46	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
21256954-1	2011	As phytochemicals have the potential to counteract adverse effects of carcinogens we investigated the influence of the flavonoids quercetin and kaempferol on benzo[a]pyrene (BaP) mediated effects on human colon cancer cells, Caco-2.	Benzo(a)pyrene	158-172	prohibitin 2	Homo sapiens	174-177
21042282-7	2011	In addition, benzo[a]pyrene treatment led to induction of NQO1 and stabilization of p63 in WT but not in NQO1-/- mouse skin and keratinocytes.	Benzo(a)pyrene	13-27	NAD(P)H dehydrogenase, quinone 1	Mus musculus	58-62
21042282-7	2011	In addition, benzo[a]pyrene treatment led to induction of NQO1 and stabilization of p63 in WT but not in NQO1-/- mouse skin and keratinocytes.	Benzo(a)pyrene	13-27	transformation related protein 63	Mus musculus	84-87
21258036-4	2011	We found that adult TRPC6-deficient mice had BP and albumin excretion rates similar to wild-type animals.	Benzo(a)pyrene	45-47	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	20-25
21383588-0	2011	Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene.	Benzo(a)pyrene	115-129	epoxide hydrolase 2	Rattus norvegicus	14-39
21383588-1	2011	We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP omega-hydroxylases and soluble epoxide hydrolase (sEH) enzymes.	Benzo(a)pyrene	30-44	epoxide hydrolase 2	Rattus norvegicus	188-213
21383588-1	2011	We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP omega-hydroxylases and soluble epoxide hydrolase (sEH) enzymes.	Benzo(a)pyrene	30-44	epoxide hydrolase 2	Rattus norvegicus	215-218
21383588-1	2011	We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP omega-hydroxylases and soluble epoxide hydrolase (sEH) enzymes.	Benzo(a)pyrene	46-49	epoxide hydrolase 2	Rattus norvegicus	188-213
21383588-1	2011	We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP omega-hydroxylases and soluble epoxide hydrolase (sEH) enzymes.	Benzo(a)pyrene	46-49	epoxide hydrolase 2	Rattus norvegicus	215-218
21383588-7	2011	Our results demonstrate that BaP alone significantly induced the expression of sEH and CYP omega-hydroxylases in the heart, liver, and kidney tissues.	Benzo(a)pyrene	29-32	epoxide hydrolase 2	Rattus norvegicus	79-82
21383588-8	2011	Treatment with TUPS significantly reversed the BaP-mediated induction of the hypertrophic markers, completely prevented the increase in the heart to body weight ratio, and reduced the BaP-induced CYP1A1, CYP1B1, CYP4F4, and CYP4F5 genes in the heart.	Benzo(a)pyrene	47-50	cytochrome P450, family 4, subfamily f, polypeptide 4	Rattus norvegicus	212-218
21383588-8	2011	Treatment with TUPS significantly reversed the BaP-mediated induction of the hypertrophic markers, completely prevented the increase in the heart to body weight ratio, and reduced the BaP-induced CYP1A1, CYP1B1, CYP4F4, and CYP4F5 genes in the heart.	Benzo(a)pyrene	47-50	cytochrome P450, family 4, subfamily f, polypeptide 5	Rattus norvegicus	224-230
21383588-8	2011	Treatment with TUPS significantly reversed the BaP-mediated induction of the hypertrophic markers, completely prevented the increase in the heart to body weight ratio, and reduced the BaP-induced CYP1A1, CYP1B1, CYP4F4, and CYP4F5 genes in the heart.	Benzo(a)pyrene	184-187	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	196-202
21383588-8	2011	Treatment with TUPS significantly reversed the BaP-mediated induction of the hypertrophic markers, completely prevented the increase in the heart to body weight ratio, and reduced the BaP-induced CYP1A1, CYP1B1, CYP4F4, and CYP4F5 genes in the heart.	Benzo(a)pyrene	184-187	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	204-210
21383588-8	2011	Treatment with TUPS significantly reversed the BaP-mediated induction of the hypertrophic markers, completely prevented the increase in the heart to body weight ratio, and reduced the BaP-induced CYP1A1, CYP1B1, CYP4F4, and CYP4F5 genes in the heart.	Benzo(a)pyrene	184-187	cytochrome P450, family 4, subfamily f, polypeptide 4	Rattus norvegicus	212-218
21383588-8	2011	Treatment with TUPS significantly reversed the BaP-mediated induction of the hypertrophic markers, completely prevented the increase in the heart to body weight ratio, and reduced the BaP-induced CYP1A1, CYP1B1, CYP4F4, and CYP4F5 genes in the heart.	Benzo(a)pyrene	184-187	cytochrome P450, family 4, subfamily f, polypeptide 5	Rattus norvegicus	224-230
21383588-9	2011	The current study demonstrates the cardioprotective effect of sEH inhibitor, TUPS, against BaP-induced cardiac hypertrophy and further confirms the role of sEH and CYP450 enzymes in the development of cardiac hypertrophy.	Benzo(a)pyrene	91-94	epoxide hydrolase 2	Rattus norvegicus	62-65
20951464-8	2011	The results also revealed significant sex differences in CYP1A1 gene expression, both in untreated cells (p=0.03), and in cells exposed to benzo[a]pyrene (p=0.017) and cigarette smoke condensate (p=0.0043).	Benzo(a)pyrene	139-153	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-63
21177068-5	2011	We demonstrated the inhibitory effects of orally administered sulforaphane on B[a]P-induced aryl hydrocarbon receptor (AHR) activation which subsequently resulted in decreased Phase-I enzyme activities in vivo.	Benzo(a)pyrene	78-83	aryl-hydrocarbon receptor	Mus musculus	92-117
21177068-5	2011	We demonstrated the inhibitory effects of orally administered sulforaphane on B[a]P-induced aryl hydrocarbon receptor (AHR) activation which subsequently resulted in decreased Phase-I enzyme activities in vivo.	Benzo(a)pyrene	78-83	aryl-hydrocarbon receptor	Mus musculus	119-122
21146218-1	2011	Both the World Health Organization and the UK Expert Panel on Air Quality Standards (EPAQS) have considered benzo(a)pyrene (BaP) as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture, when recommending their respective guidelines for PAHs in outdoor air.	Benzo(a)pyrene	108-122	prohibitin 2	Homo sapiens	124-127
21286013-1	2011	Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is easily introduced to humans via consumption of grilled or smoked meat.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
20888899-0	2011	Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.	Benzo(a)pyrene	0-14	H2A.X variant histone	Homo sapiens	31-35
20888899-0	2011	Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.	Benzo(a)pyrene	0-14	ATM serine/threonine kinase	Homo sapiens	91-94
20888899-0	2011	Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.	Benzo(a)pyrene	0-14	ATR serine/threonine kinase	Homo sapiens	96-99
20888899-0	2011	Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.	Benzo(a)pyrene	0-14	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	105-111
20888899-2	2011	While it has been reported that benzo[a]pyrene (BaP) cannot induce gammaH2AX alone in several cell lines, we have shown that BaP alone could induce gammaH2AX in human amnion FL cells.	Benzo(a)pyrene	125-128	H2A.X variant histone	Mus musculus	148-157
20888899-3	2011	Thus, we further examined the ability of BaP to induce gammaH2AX in different cell systems.	Benzo(a)pyrene	41-44	H2A.X variant histone	Mus musculus	55-64
20888899-4	2011	It was shown that BaP-induced gammaH2AX in HeLa cells in a time- and dose-dependent manner.	Benzo(a)pyrene	18-21	H2A.X variant histone	Mus musculus	30-39
20888899-5	2011	BaP also induced gammaH2AX in ATM(-/-) mouse fibroblasts, DNA-PKcs(-/-) mouse fibroblasts, and a genetically modified human osteosarcoma U2OS cell line.	Benzo(a)pyrene	0-3	H2A.X variant histone	Mus musculus	17-26
20888899-5	2011	BaP also induced gammaH2AX in ATM(-/-) mouse fibroblasts, DNA-PKcs(-/-) mouse fibroblasts, and a genetically modified human osteosarcoma U2OS cell line.	Benzo(a)pyrene	0-3	ATM serine/threonine kinase	Homo sapiens	30-33
20888899-6	2011	PI3K inhibitors caffeine and wortmannin were then used in an effort to identify the kinase(s) responsible for BaP-induced gammaH2AX.	Benzo(a)pyrene	110-113	H2A.X variant histone	Mus musculus	122-131
20888899-8	2011	On the other hand, caffeine or wortmannin can inhibit BaP-induced gammaH2AX in either U2OS, DNA-PKcs(-/-) or ATM(-/-) cells.	Benzo(a)pyrene	54-57	H2A.X variant histone	Mus musculus	66-75
20888899-8	2011	On the other hand, caffeine or wortmannin can inhibit BaP-induced gammaH2AX in either U2OS, DNA-PKcs(-/-) or ATM(-/-) cells.	Benzo(a)pyrene	54-57	ATM serine/threonine kinase	Homo sapiens	109-112
20888899-9	2011	Taken together, these data suggest that BaP alone can induce H2AX phosphorylation in certain cell systems, and that members of the PI3K family, including ATM, ATR, and DNA-PK can participate in the phosphorylation of H2AX in the various cell types.	Benzo(a)pyrene	40-43	H2A.X variant histone	Homo sapiens	61-65
20947330-0	2011	An amperometric biosensor based on rat cytochrome p450 1A1 for benzo[a]pyrene determination.	Benzo(a)pyrene	63-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	39-58
20947330-6	2011	The direct electrochemistry of CYP1A1 in a nano-SWy-2-DHP film on an edge-plane pyrolytic graphite electrode (EPG) has been obtained and the catalytic activity of the enzyme to benzo[a]pyrene has been investigated by the cyclic voltammetry.	Benzo(a)pyrene	177-191	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	31-37
20947330-9	2011	Upon the addition of its substrate benzo[a]pyrene (B[a]P) to the air-saturated solution, the reduction peak current of dissolved oxygen increased, which indicates the catalytic behavior of CYP1A1 to B[a]P. By amperometry a calibration linear range for B[a]P was obtained to be 3.31-16.56 muM with a sensitivity of 58.57 muA mM(-1).	Benzo(a)pyrene	35-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	189-195
21028851-2	2011	Benzo[a]pyrene (B[a]P), a prototypic PAH, is metabolized by cytochrome P450 (P450) 1A1/1B1 and epoxide hydrolase to (-)-B[a]P-7,8-dihydro-7,8-diol (B[a]P-7,8-dihydrodiol).	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	60-90
21078407-0	2011	Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa.	Benzo(a)pyrene	72-86	DNA polymerase kappa	Homo sapiens	112-132
21051739-1	2011	Disruption of the dopamine D(5) receptor gene in mice increases BP and causes salt sensitivity.	Benzo(a)pyrene	64-66	dopamine receptor D5	Mus musculus	18-40
21644163-7	2011	The risk assessment was conducted using the toxic equivalent factor (TEF) considering the toxicity of the individual PAHs compared to BaP.	Benzo(a)pyrene	134-137	TEF transcription factor, PAR bZIP family member	Homo sapiens	69-72
22126617-0	2011	Effect of benzo[a]pyrene on the production of vascular endothelial growth factor by human eosinophilic leukemia EoL-1 cells.	Benzo(a)pyrene	10-24	vascular endothelial growth factor A	Homo sapiens	46-80
22126617-3	2011	In this study, we investigated the effect of BaP on the production of vascular endothelial growth factor (VEGF) using an in vitro eosinophilic EoL-1 cell and human umbilical vein endothelial cell (HUVEC) co-culture system.	Benzo(a)pyrene	45-48	vascular endothelial growth factor A	Homo sapiens	70-104
22126617-3	2011	In this study, we investigated the effect of BaP on the production of vascular endothelial growth factor (VEGF) using an in vitro eosinophilic EoL-1 cell and human umbilical vein endothelial cell (HUVEC) co-culture system.	Benzo(a)pyrene	45-48	vascular endothelial growth factor A	Homo sapiens	106-110
22126617-7	2011	Furthermore, BaP-induced expression of VEGF mRNA was reduced by the ERK inhibitor PD98059.	Benzo(a)pyrene	13-16	vascular endothelial growth factor A	Homo sapiens	39-43
22126617-7	2011	Furthermore, BaP-induced expression of VEGF mRNA was reduced by the ERK inhibitor PD98059.	Benzo(a)pyrene	13-16	mitogen-activated protein kinase 1	Homo sapiens	68-71
22126617-8	2011	Results from this study suggested that BaP might affect the growth of endothelial cells through the modulation of VEGF production by eosinophils.	Benzo(a)pyrene	39-42	vascular endothelial growth factor A	Homo sapiens	114-118
22167217-4	2011	Here, the effect of CYP1A1/2 induction due to their prototype flavonoid inducer, beta-naphthoflavone (BNF), on BaP- and PhPI-derived DNA adduct formation in rats was examined.	Benzo(a)pyrene	111-114	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	20-26
22167217-12	2011	The BNF induction of CYP1A1/2 resulted in a significant increase in the formation of BaP- and PhIP-DNA adducts in liver and in the distal part of the small intestine, respectively.	Benzo(a)pyrene	85-88	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	21-27
21786685-1	2011	Effect of carcinogenic polycyclic aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and 3-methylcholanthrene (MC) on transcription factor NF-kappaB activation was studied.	Benzo(a)pyrene	78-80	nuclear factor kappa B subunit 1	Homo sapiens	136-145
21786685-6	2011	NF-kappaB activation by BP and MC in hepatoma G27 cells was significantly higher in hepatima G27 cells than in HepG2 cells both in proliferating and resting cells.	Benzo(a)pyrene	24-26	nuclear factor kappa B subunit 1	Homo sapiens	0-9
21319374-0	2011	[Effect of benzo(a)pyrene on platelet aggregation and expression of P-selectin].	Benzo(a)pyrene	11-25	selectin P	Homo sapiens	68-78
21319374-1	2011	OBJECTIVE: To investigate the effect of benzo(a)pyrene (BaP) on platelet aggregation and expression of P-selectin.	Benzo(a)pyrene	56-59	selectin P	Homo sapiens	103-113
21319374-4	2011	RESULT: BaP (10 mumol/L, 1 mumol/L and 0.1 mumol/L) did not induce platelet aggregation; however, preincubation with BaP (10 mumol/L) significantly enhanced ADP-induced platelet aggregation (P &lt; 0.01) and platelet aggregation was (80 +- 10)%, while BaP-preincubation failed to enhance platelet aggregation under collagen and thrombin stimulation.	Benzo(a)pyrene	117-120	coagulation factor II, thrombin	Homo sapiens	328-336
21319374-4	2011	RESULT: BaP (10 mumol/L, 1 mumol/L and 0.1 mumol/L) did not induce platelet aggregation; however, preincubation with BaP (10 mumol/L) significantly enhanced ADP-induced platelet aggregation (P &lt; 0.01) and platelet aggregation was (80 +- 10)%, while BaP-preincubation failed to enhance platelet aggregation under collagen and thrombin stimulation.	Benzo(a)pyrene	117-120	coagulation factor II, thrombin	Homo sapiens	328-336
21319374-6	2011	CONCLUSION: BaP can stimulate ADP-induced platelet aggregation and P-selectin expression, probably through the interaction with ADP-mediated signal pathway.	Benzo(a)pyrene	12-15	selectin P	Homo sapiens	67-77
20920559-0	2010	Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague-Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate.	Benzo(a)pyrene	121-135	peroxisome proliferator activated receptor alpha	Rattus norvegicus	16-20
20851761-5	2010	BaP treatment (1) significantly lowered levels of vitamins A, C, and E and of glutathione; (2) reduced activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferases; and (3) significantly increased lipid peroxidation levels.	Benzo(a)pyrene	0-3	catalase	Mus musculus	139-147
20740637-5	2010	In the particular case of benzo[a]pyrene induction of K-Ras codon 12 TGT mutation in the A/J mouse lung, measurement of tumor-associated oncomutation was shown to be an earlier and more sensitive endpoint than tumor response.	Benzo(a)pyrene	26-40	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	54-59
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	67-81	zinc fingers and homeoboxes 2	Homo sapiens	101-104
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	83-85	zinc fingers and homeoboxes 2	Homo sapiens	101-104
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	83-85	mitogen-activated protein kinase 1	Homo sapiens	106-109
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	83-85	MDM2 proto-oncogene	Homo sapiens	111-115
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	83-85	tumor protein p53	Homo sapiens	117-120
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	90-92	zinc fingers and homeoboxes 2	Homo sapiens	101-104
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	90-92	MDM2 proto-oncogene	Homo sapiens	111-115
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	90-92	zinc fingers and homeoboxes 2	Homo sapiens	101-104
20840854-3	2010	We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest.	Benzo(a)pyrene	90-92	MDM2 proto-oncogene	Homo sapiens	111-115
20840854-5	2010	This treatment also resulted in the attenuation of BP-induced Mdm2 phosphorylation at Ser166 and amplification of the p53 Ser15 response.	Benzo(a)pyrene	51-53	MDM2 proto-oncogene	Homo sapiens	62-66
20840854-7	2010	A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis.	Benzo(a)pyrene	134-136	pyruvate carboxylase	Homo sapiens	14-17
20840854-7	2010	A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis.	Benzo(a)pyrene	134-136	pyruvate carboxylase	Homo sapiens	19-29
20840854-7	2010	A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis.	Benzo(a)pyrene	134-136	tumor protein p53	Homo sapiens	145-148
20840854-10	2010	This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm.	Benzo(a)pyrene	123-125	forkhead box O3	Homo sapiens	61-67
20840854-10	2010	This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm.	Benzo(a)pyrene	123-125	tumor protein p53	Homo sapiens	72-75
20840854-10	2010	This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm.	Benzo(a)pyrene	123-125	forkhead box O3	Homo sapiens	160-166
20840854-10	2010	This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm.	Benzo(a)pyrene	123-125	tumor protein p53	Homo sapiens	194-197
20607245-5	2010	RESULTS: The median PMU-PCA3 score was 1.56 in men with BP, 2.01 in men with HGPIN (p = 0.128) and 9.06 in men with PCa (p = 0.008).	Benzo(a)pyrene	56-58	prostate cancer associated 3	Homo sapiens	24-28
20607245-7	2010	Fixing the sensitivity of the PMU-PCA3 score at 90%, its specificity was 79% in men with BP and 69% in men with isolated HGPIN.	Benzo(a)pyrene	89-91	prostate cancer associated 3	Homo sapiens	34-38
20973527-3	2010	We examine the effects of the PAH-substrate interaction on the oxidation of surface-adsorbed anthracene, pyrene, and benzo[a]pyrene by ozone (O(3)) using density functional theory.	Benzo(a)pyrene	117-131	phenylalanine hydroxylase	Homo sapiens	30-33
20127859-0	2010	Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.	Benzo(a)pyrene	5-19	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	102-106
20127859-3	2010	Following high dosage of oral BaP (125 mg/kg/day), ablation of the mouse Cyp1a1 gene causes immunosuppression and death within ~28 days, whereas Cyp1(+/+) wild-type mice remain healthy for &gt;12 months on this regimen.	Benzo(a)pyrene	30-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	73-79
20127859-3	2010	Following high dosage of oral BaP (125 mg/kg/day), ablation of the mouse Cyp1a1 gene causes immunosuppression and death within ~28 days, whereas Cyp1(+/+) wild-type mice remain healthy for &gt;12 months on this regimen.	Benzo(a)pyrene	30-33	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	73-77
20557297-9	2010	In contrast, Api g 1-primed DCs from BP allergics significantly enhanced the production of the Th1 cytokine IFN-gamma and significantly down-regulated IL-13 compared to maturation factors.	Benzo(a)pyrene	37-39	negative elongation factor complex member C/D	Homo sapiens	95-98
20557297-9	2010	In contrast, Api g 1-primed DCs from BP allergics significantly enhanced the production of the Th1 cytokine IFN-gamma and significantly down-regulated IL-13 compared to maturation factors.	Benzo(a)pyrene	37-39	interferon gamma	Homo sapiens	108-117
20557297-9	2010	In contrast, Api g 1-primed DCs from BP allergics significantly enhanced the production of the Th1 cytokine IFN-gamma and significantly down-regulated IL-13 compared to maturation factors.	Benzo(a)pyrene	37-39	interleukin 13	Homo sapiens	151-156
20868228-7	2010	Inhibition of promoter activity depends on the presence of an intact xenobiotic responsive element (XRE) and is also observed with benzo[a]pyrene, a typical ligand of the aryl hydrocarbon receptor (AhR), suggesting that suppressive effects of nGBS are mediated via AhR/XRE pathway.	Benzo(a)pyrene	131-145	aryl hydrocarbon receptor	Homo sapiens	171-196
20868228-7	2010	Inhibition of promoter activity depends on the presence of an intact xenobiotic responsive element (XRE) and is also observed with benzo[a]pyrene, a typical ligand of the aryl hydrocarbon receptor (AhR), suggesting that suppressive effects of nGBS are mediated via AhR/XRE pathway.	Benzo(a)pyrene	131-145	aryl hydrocarbon receptor	Homo sapiens	198-201
20868228-7	2010	Inhibition of promoter activity depends on the presence of an intact xenobiotic responsive element (XRE) and is also observed with benzo[a]pyrene, a typical ligand of the aryl hydrocarbon receptor (AhR), suggesting that suppressive effects of nGBS are mediated via AhR/XRE pathway.	Benzo(a)pyrene	131-145	aryl hydrocarbon receptor	Homo sapiens	265-268
20847141-6	2010	Accordingly, these results suggest that RGS2 acts within the kidney to modulate BP and prevent hypertension.	Benzo(a)pyrene	80-82	regulator of G-protein signaling 2	Mus musculus	40-44
20667428-5	2010	The maximum level for benzo[a]pyrene (BaP) of 5 microg/kg in smoked meat products was not exceeded in any samples.	Benzo(a)pyrene	22-36	prohibitin 2	Homo sapiens	38-41
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	138-152	cytochrome P450, family 1, subfamily A	Danio rerio	50-55
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	138-152	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	57-63
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	138-152	cytochrome P450, family 1, subfamily C, polypeptide 1	Danio rerio	65-71
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	138-152	cytochrome P450, family 1, subfamily C, polypeptide 2	Danio rerio	73-79
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	138-152	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	85-91
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	154-157	cytochrome P450, family 1, subfamily A	Danio rerio	50-55
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	154-157	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	57-63
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	154-157	cytochrome P450, family 1, subfamily C, polypeptide 1	Danio rerio	65-71
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	154-157	cytochrome P450, family 1, subfamily C, polypeptide 2	Danio rerio	73-79
20599672-2	2010	We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP).	Benzo(a)pyrene	154-157	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	85-91
20599672-6	2010	CYP1B1 and CYP1C2 had the highest rates of BaP metabolism.	Benzo(a)pyrene	43-46	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	0-6
20599672-6	2010	CYP1B1 and CYP1C2 had the highest rates of BaP metabolism.	Benzo(a)pyrene	43-46	cytochrome P450, family 1, subfamily C, polypeptide 2	Danio rerio	11-17
20599672-10	2010	CYP1D1 had very low activities for all substrates except BaP, and a different regioselectivity for BaP, suggesting that CYP1D1 function may be different from other CYP1s.	Benzo(a)pyrene	57-60	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	0-6
20599672-10	2010	CYP1D1 had very low activities for all substrates except BaP, and a different regioselectivity for BaP, suggesting that CYP1D1 function may be different from other CYP1s.	Benzo(a)pyrene	57-60	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	120-126
20599672-10	2010	CYP1D1 had very low activities for all substrates except BaP, and a different regioselectivity for BaP, suggesting that CYP1D1 function may be different from other CYP1s.	Benzo(a)pyrene	99-102	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	0-6
20599672-10	2010	CYP1D1 had very low activities for all substrates except BaP, and a different regioselectivity for BaP, suggesting that CYP1D1 function may be different from other CYP1s.	Benzo(a)pyrene	99-102	cytochrome P450, family 1, subfamily D, polypeptide 1	Danio rerio	120-126
20501349-7	2010	RESULTS: CYP1A activity was induced by BaP in KC but not ER larvae, and KC larvae demonstrated a greater reduction in whole-body concentrations of BaP over time.	Benzo(a)pyrene	39-42	cytochrome P450 1A1	Fundulus heteroclitus	9-14
20647767-4	2010	TCL-1 cells exposed to both nicotine and benzo(a)pyrene exhibited significant, dose-dependent downregulation of miR-146a.	Benzo(a)pyrene	41-55	TCL1 family AKT coactivator A	Homo sapiens	0-5
20647767-4	2010	TCL-1 cells exposed to both nicotine and benzo(a)pyrene exhibited significant, dose-dependent downregulation of miR-146a.	Benzo(a)pyrene	41-55	microRNA 146a	Homo sapiens	112-120
20740637-5	2010	In the particular case of benzo[a]pyrene induction of K-Ras codon 12 TGT mutation in the A/J mouse lung, measurement of tumor-associated oncomutation was shown to be an earlier and more sensitive endpoint than tumor response.	Benzo(a)pyrene	26-40	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	69-72
20511593-6	2010	Apart from UV light, TREX1 is induced by other DNA damaging agents such as benzo(a)pyrene and hydrogen peroxide.	Benzo(a)pyrene	75-89	three prime repair exonuclease 1	Homo sapiens	21-26
20708262-3	2010	In this study, we evaluated the protective effects of PE on rats exposed to benzo[a]pyrene (BaP).	Benzo(a)pyrene	76-90	prohibitin 2	Rattus norvegicus	92-95
20655936-0	2010	Exposure to di(n-butyl)phthalate and benzo(a)pyrene alters IL-1beta secretion and subset expression of testicular macrophages, resulting in decreased testosterone production in rats.	Benzo(a)pyrene	37-51	interleukin 1 beta	Rattus norvegicus	59-67
20655936-9	2010	DBP and BaP acted additively, as demonstrated by greater IL-1beta secretion relative to each compound alone.	Benzo(a)pyrene	8-11	interleukin 1 beta	Rattus norvegicus	57-65
20655390-0	2010	UVB in solar-simulated light causes formation of BaP-photoproducts capable of generating phosphorylated histone H2AX.	Benzo(a)pyrene	49-52	H2A.X variant histone	Homo sapiens	104-116
20655390-2	2010	Our previous paper showed that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL) induced phosphorylation of histone H2AX (gamma-H2AX) [T. Toyooka, G. Ohnuki, Y. Ibuki, Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX, Mutat.	Benzo(a)pyrene	31-45	H2A.X variant histone	Homo sapiens	118-130
20655390-2	2010	Our previous paper showed that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL) induced phosphorylation of histone H2AX (gamma-H2AX) [T. Toyooka, G. Ohnuki, Y. Ibuki, Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX, Mutat.	Benzo(a)pyrene	31-45	H2A.X variant histone	Homo sapiens	250-262
20655390-2	2010	Our previous paper showed that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL) induced phosphorylation of histone H2AX (gamma-H2AX) [T. Toyooka, G. Ohnuki, Y. Ibuki, Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX, Mutat.	Benzo(a)pyrene	47-50	H2A.X variant histone	Homo sapiens	118-130
20655390-2	2010	Our previous paper showed that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL) induced phosphorylation of histone H2AX (gamma-H2AX) [T. Toyooka, G. Ohnuki, Y. Ibuki, Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX, Mutat.	Benzo(a)pyrene	47-50	H2A.X variant histone	Homo sapiens	250-262
20655390-2	2010	Our previous paper showed that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL) induced phosphorylation of histone H2AX (gamma-H2AX) [T. Toyooka, G. Ohnuki, Y. Ibuki, Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX, Mutat.	Benzo(a)pyrene	208-222	H2A.X variant histone	Homo sapiens	118-130
20607163-7	2010	This relatively high value of conductance for the single Au(tip)-1BP9-Au(substrate) junction is attributed to an increased coupling of the BP unit to the adjacent electrode, i.e. the STM-tip or the Au-substrate.	Benzo(a)pyrene	66-68	sulfotransferase family 1A member 3	Homo sapiens	183-186
20674550-4	2010	In a genome-wide P450 microarray screen, we identified six PAH-responsive P450 genes (Pc-pah1-Pc-pah6) inducible by PAHs of varying ring size, namely naphthalene, phenanthrene, pyrene, and benzo(a)pyrene (BaP).	Benzo(a)pyrene	189-203	prohibitin 2	Homo sapiens	205-208
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	Benzo(a)pyrene	0-2	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-118
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	Benzo(a)pyrene	0-2	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	120-123
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	Benzo(a)pyrene	0-2	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	145-151
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	Benzo(a)pyrene	0-2	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	161-167
20634147-7	2010	The pGL3 plasmid containing a luciferase gene was damaged with diol epoxides of benzo[a]pyrene (B[a]P-DE), dibenzo[a,l]pyrene (DB[a,l]P-DE), benzo[g]chrysene (B[g]Ch-DE), and benzo[c]phenanthrene (B[c]Ph-DE).	Benzo(a)pyrene	80-94	succinate dehydrogenase complex subunit C	Homo sapiens	4-8
20615557-7	2010	Exposure to TCDD, BaP and ANF alone all significantly increased CYP1A mRNA expression, while only TCDD consistently increased CYP1C1 expression.	Benzo(a)pyrene	18-21	cytochrome P450, family 1, subfamily A	Danio rerio	64-69
20615557-9	2010	BaP alone had no effect on CYP1C1 expression, but decreased COX2b expression when alone or in combination with ANF.	Benzo(a)pyrene	0-3	prostaglandin-endoperoxide synthase 2b	Danio rerio	60-65
20615557-10	2010	In fact, ANF exhibited additive agonistic effects on expression of CYP1A and CYP1C1 with both BaP and TCDD, although additive or potentiating effects of ANF on CYP1C2 and COX2b were observed with only BaP.	Benzo(a)pyrene	94-97	cytochrome P450, family 1, subfamily A	Danio rerio	67-72
20615557-10	2010	In fact, ANF exhibited additive agonistic effects on expression of CYP1A and CYP1C1 with both BaP and TCDD, although additive or potentiating effects of ANF on CYP1C2 and COX2b were observed with only BaP.	Benzo(a)pyrene	94-97	cytochrome P450, family 1, subfamily C, polypeptide 1	Danio rerio	77-83
20797764-7	2010	In addition, fish were exposed to the potent CYP1A inducers benzo(a)pyrene (BaP) and PCB126 in combination with AHA.	Benzo(a)pyrene	60-74	cytochrome P450 1A1	Gasterosteus aculeatus	45-50
20797764-7	2010	In addition, fish were exposed to the potent CYP1A inducers benzo(a)pyrene (BaP) and PCB126 in combination with AHA.	Benzo(a)pyrene	76-79	cytochrome P450 1A1	Gasterosteus aculeatus	45-50
20033074-2	2010	Neuropeptide Y (NPY) plays an important role in BP homeostasis.	Benzo(a)pyrene	48-50	neuropeptide Y	Homo sapiens	0-14
20158316-8	2010	Our results suggested that the BP-conjugated NPs are useful for localized delivery of BMP-2 in bone repair and regeneration, but they are not effective for bone targeting after intravenous administration.	Benzo(a)pyrene	31-33	bone morphogenetic protein 2	Rattus norvegicus	86-91
20033074-2	2010	Neuropeptide Y (NPY) plays an important role in BP homeostasis.	Benzo(a)pyrene	48-50	neuropeptide Y	Homo sapiens	16-19
20542099-3	2010	When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme.	Benzo(a)pyrene	29-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-57
20599218-6	2010	We hypothesized that lack of NKX2.2 expression in BP-TCs might be useful to distinguish BP- from GI-NETs, and evaluated NKX2.2 expression in a larger number of BP-TCs.	Benzo(a)pyrene	50-52	NK2 homeobox 2	Homo sapiens	29-35
20542099-3	2010	When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme.	Benzo(a)pyrene	146-149	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-57
20542099-3	2010	When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme.	Benzo(a)pyrene	146-149	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	172-178
20542099-3	2010	When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme.	Benzo(a)pyrene	146-149	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	183-189
20981351-6	2010	One of the polymorphisms of the RGS2 gene was extracted as being able to influence the effect of these treatments to reduce BP.	Benzo(a)pyrene	124-126	regulator of G protein signaling 2	Homo sapiens	32-36
20981351-7	2010	At eight weeks, BP change showed a significant interaction between the A-638G polymorphism of Regulator of G protein signaling-2 (RGS2) gene and treatment with azelnidipine or temocapril.	Benzo(a)pyrene	16-18	regulator of G protein signaling 2	Homo sapiens	94-128
20981351-7	2010	At eight weeks, BP change showed a significant interaction between the A-638G polymorphism of Regulator of G protein signaling-2 (RGS2) gene and treatment with azelnidipine or temocapril.	Benzo(a)pyrene	16-18	regulator of G protein signaling 2	Homo sapiens	130-134
20562004-0	2010	All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells.	Benzo(a)pyrene	74-88	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	105-137
20457487-2	2010	The estimation of benzo(a)pyrene (BaP) concentrations in ambient air is very important from an environmental point of view especially with the introduction of the Directive 2004/107/EC and due to the carcinogenic character of this pollutant.	Benzo(a)pyrene	18-32	prohibitin 2	Homo sapiens	34-37
20570689-4	2010	In Hepa-1 cells, 3MC and benzo[a]pyrene (BaP) induced FMO3 mRNA &gt;30-fold.	Benzo(a)pyrene	25-39	flavin containing monooxygenase 3	Mus musculus	54-58
20570689-4	2010	In Hepa-1 cells, 3MC and benzo[a]pyrene (BaP) induced FMO3 mRNA &gt;30-fold.	Benzo(a)pyrene	41-44	flavin containing monooxygenase 3	Mus musculus	54-58
20570689-5	2010	Induction by 3MC and BaP was AHR dependent but, surprisingly, the potent AHR agonist, TCDD, did not induce FMO3 mRNA in Hepa-1 cells nor did chromatin immunoprecipitation assays detect recruitment of AHR or ARNT to Fmo3 regulatory elements after exposure to 3MC in liver or in Hepa-1 cells.	Benzo(a)pyrene	21-24	aryl-hydrocarbon receptor	Mus musculus	29-32
20464547-4	2010	The data of RT-PCR analysis indicated that treatments of human lung adenocarcinoma CL5 cells with benzo(a)pyrene and a PAH mixture motorcycle exhaust particulate (MEP) extracts increased FGF-9 mRNA expression.	Benzo(a)pyrene	98-112	fibroblast growth factor 9	Homo sapiens	187-192
20464547-6	2010	The results of immunoblot analysis and Matrigel assay showed that benzo(a)pyrene and MEP extracts produced a concomitant induction of FGF-9 protein and invasive ability of CL5 cells.	Benzo(a)pyrene	66-80	fibroblast growth factor 9	Homo sapiens	134-139
20464547-7	2010	The benzo(a)pyrene- and MEP-induced invasion was suppressed by FGF-9 neutralizing antibodies.	Benzo(a)pyrene	4-18	fibroblast growth factor 9	Homo sapiens	63-68
20478378-1	2010	We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs).	Benzo(a)pyrene	201-204	aryl-hydrocarbon receptor	Mus musculus	39-64
20478378-1	2010	We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs).	Benzo(a)pyrene	201-204	aryl-hydrocarbon receptor	Mus musculus	66-69
20478378-1	2010	We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs).	Benzo(a)pyrene	201-204	superoxide dismutase 1, soluble	Mus musculus	152-155
20600538-0	2010	Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals.	Benzo(a)pyrene	43-57	cytochrome P450 family 1 subfamily A member 1	Equus caballus	78-97
20641036-4	2010	We thus screened a combinatorial peptide library and identified a tetrameric tripeptide, Cripto blocking peptide (BP), which prevents Cripto/ALK-4 receptor interaction and interferes with Cripto signaling.	Benzo(a)pyrene	114-116	teratocarcinoma-derived growth factor 1	Mus musculus	89-95
20641036-4	2010	We thus screened a combinatorial peptide library and identified a tetrameric tripeptide, Cripto blocking peptide (BP), which prevents Cripto/ALK-4 receptor interaction and interferes with Cripto signaling.	Benzo(a)pyrene	114-116	teratocarcinoma-derived growth factor 1	Mus musculus	134-140
20641036-4	2010	We thus screened a combinatorial peptide library and identified a tetrameric tripeptide, Cripto blocking peptide (BP), which prevents Cripto/ALK-4 receptor interaction and interferes with Cripto signaling.	Benzo(a)pyrene	114-116	activin A receptor type 1B	Rattus norvegicus	141-146
20641036-4	2010	We thus screened a combinatorial peptide library and identified a tetrameric tripeptide, Cripto blocking peptide (BP), which prevents Cripto/ALK-4 receptor interaction and interferes with Cripto signaling.	Benzo(a)pyrene	114-116	teratocarcinoma-derived growth factor 1	Mus musculus	134-140
20498004-0	2010	Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message.	Benzo(a)pyrene	0-14	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
20498004-0	2010	Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message.	Benzo(a)pyrene	0-14	kelch like ECH associated protein 1	Homo sapiens	64-69
20498004-2	2010	Among the 21 downregulated transcripts, we found that BaP suppresses the Keap1 transcript by 7.5-fold.	Benzo(a)pyrene	54-57	kelch like ECH associated protein 1	Homo sapiens	73-78
20498004-3	2010	Subsequent analyses revealed that BaP significantly suppresses the Keap1 message and protein levels to about 40 and 60%, respectively, of the vehicle controls in Jurkat cells without reactive oxygen species involvement.	Benzo(a)pyrene	34-37	kelch like ECH associated protein 1	Homo sapiens	67-72
20498004-5	2010	The same BaP treatment to Hepa1c1c7 cells also downregulates the Keap1 message and protein levels to a similar extent.	Benzo(a)pyrene	9-12	kelch-like ECH-associated protein 1	Mus musculus	65-70
20498004-7	2010	Although both Nrf2 target messages nqo1 and gstp1 are upregulated by BaP in Jurkat cells, only GSTP1 is upregulated at the protein level.	Benzo(a)pyrene	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
20498004-7	2010	Although both Nrf2 target messages nqo1 and gstp1 are upregulated by BaP in Jurkat cells, only GSTP1 is upregulated at the protein level.	Benzo(a)pyrene	69-72	NAD(P)H quinone dehydrogenase 1	Homo sapiens	35-39
20498004-7	2010	Although both Nrf2 target messages nqo1 and gstp1 are upregulated by BaP in Jurkat cells, only GSTP1 is upregulated at the protein level.	Benzo(a)pyrene	69-72	glutathione S-transferase pi 1	Homo sapiens	44-49
20498004-9	2010	We concluded that BaP, but not its metabolites, increases the amount of the nuclear Nrf2 protein by downregulating the Keap1 message in Jurkat cells.	Benzo(a)pyrene	18-21	NFE2 like bZIP transcription factor 2	Homo sapiens	84-88
20498004-9	2010	We concluded that BaP, but not its metabolites, increases the amount of the nuclear Nrf2 protein by downregulating the Keap1 message in Jurkat cells.	Benzo(a)pyrene	18-21	kelch like ECH associated protein 1	Homo sapiens	119-124
20412841-5	2010	The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver.	Benzo(a)pyrene	26-29	interleukin 1 beta	Mus musculus	57-65
20412841-5	2010	The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver.	Benzo(a)pyrene	26-29	tumor necrosis factor	Mus musculus	83-91
20553787-10	2010	Chrysoeriol (1-10 microM) dose-dependently inhibited both EROD activity and the gene expressions of CYP1A1, 1B1 and 1A2 stimulated by treatment with BaP.	Benzo(a)pyrene	149-152	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-111
20400470-2	2010	Pharmacokinetic analysis of blood BaP levels indicated significantly lower rates of BaP clearance in IE-Cpr-null than in wild-type (WT) mice, after oral BaP (30 mg/kg) treatment.	Benzo(a)pyrene	84-87	cytochrome p450 oxidoreductase	Mus musculus	104-107
20400470-2	2010	Pharmacokinetic analysis of blood BaP levels indicated significantly lower rates of BaP clearance in IE-Cpr-null than in wild-type (WT) mice, after oral BaP (30 mg/kg) treatment.	Benzo(a)pyrene	84-87	cytochrome p450 oxidoreductase	Mus musculus	104-107
20400470-6	2010	In addition, we observed greater differences in the rates of clearance of oral BaP, between WT and IE-Cpr-null mice, in mice pretreated with beta-naphthoflavone, to induce CYP1A1 expression, than in untreated mice.	Benzo(a)pyrene	79-82	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	172-178
20400470-7	2010	The onset of induction (at 2 h after dosing) of CYP1A1 protein expression by oral BaP administration was earlier in the SI than in extra-gut organs analyzed; for liver, lung, and kidney, induction was not observed until 4 h after dosing.	Benzo(a)pyrene	82-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	48-54
20400470-8	2010	Furthermore, BaP tissue burdens in SI and extra-gut organs of IE-Cpr-null mice were greater than burdens in corresponding organs of WT mice, at 6 or 24 h after BaP administration.	Benzo(a)pyrene	13-16	cytochrome p450 oxidoreductase	Mus musculus	65-68
20400470-8	2010	Furthermore, BaP tissue burdens in SI and extra-gut organs of IE-Cpr-null mice were greater than burdens in corresponding organs of WT mice, at 6 or 24 h after BaP administration.	Benzo(a)pyrene	160-163	cytochrome p450 oxidoreductase	Mus musculus	65-68
20400470-9	2010	Taken together, these findings strongly support the concept that small-intestinal CYP1A1 induction is a critical factor in protection against systemic exposure to oral BaP.	Benzo(a)pyrene	168-171	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-88
20371670-0	2010	Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.	Benzo(a)pyrene	62-76	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	24-30
20371670-4	2010	This lab has previously shown that Cyp1a1(-/-) global knockout mice treated by oral administration of BaP die at 28 to 32 days with immunosuppression, whereas wild-type mice remain healthy for 1 year on high BaP doses (125 mg/kg/day).	Benzo(a)pyrene	102-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	35-41
20371670-5	2010	Thus, for oral BaP, CYP1A1 is more important in detoxication than in metabolic activation.	Benzo(a)pyrene	15-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-26
20371670-6	2010	After several days of oral BaP, we found surprisingly low CYP1A1 levels in liver, compared with that in small intestine; we postulated that this finding might reflect efficient detoxication of oral BaP in proximal small intestine such that significant amounts of the inducer BaP no longer reach the liver.	Benzo(a)pyrene	27-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	58-64
20371670-10	2010	We conclude that small intestine CYP1A1, and not liver CYP1A1, is critically important in oral BaP detoxication.	Benzo(a)pyrene	95-98	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-39
19914913-7	2010	Benzo[a]pyrene (BaP) was present in 75% of the samples (0.046-0.101 ng/cm(2)).	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
20466593-0	2010	Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat follicle development.	Benzo(a)pyrene	75-89	aryl hydrocarbon receptor	Rattus norvegicus	0-25
20466593-1	2010	It has been shown that benzo[a]pyrene, a key component of cigarette smoke and an aryl hydrocarbon receptor (AhR) ligand, reduced growth of isolated rat follicles in vitro.	Benzo(a)pyrene	23-37	aryl hydrocarbon receptor	Rattus norvegicus	81-106
20466593-1	2010	It has been shown that benzo[a]pyrene, a key component of cigarette smoke and an aryl hydrocarbon receptor (AhR) ligand, reduced growth of isolated rat follicles in vitro.	Benzo(a)pyrene	23-37	aryl hydrocarbon receptor	Rattus norvegicus	108-111
20466593-3	2010	This study proposed that the reported adverse effects of benzo[a]pyrene on follicle growth are mediated through AhR activation.	Benzo(a)pyrene	57-71	aryl hydrocarbon receptor	Rattus norvegicus	112-115
20466593-7	2010	The results suggest that the adverse effects of benzo[a]pyrene on follicle growth, steroidogenesis and AMH output are mediated through activation of the AhR.	Benzo(a)pyrene	48-62	anti-Mullerian hormone	Rattus norvegicus	103-106
20466593-7	2010	The results suggest that the adverse effects of benzo[a]pyrene on follicle growth, steroidogenesis and AMH output are mediated through activation of the AhR.	Benzo(a)pyrene	48-62	aryl hydrocarbon receptor	Rattus norvegicus	153-156
20466593-8	2010	Moreover, AhR antagonists such as resveratrol and 3,4-DMF may have therapeutic benefit in protecting the ovary against the adverse effects of AhR ligands, including benzo[a]pyrene.	Benzo(a)pyrene	165-179	aryl hydrocarbon receptor	Rattus norvegicus	10-13
20466593-8	2010	Moreover, AhR antagonists such as resveratrol and 3,4-DMF may have therapeutic benefit in protecting the ovary against the adverse effects of AhR ligands, including benzo[a]pyrene.	Benzo(a)pyrene	165-179	aryl hydrocarbon receptor	Rattus norvegicus	142-145
20553787-11	2010	In addition, the same amounts of chrysoeriol significantly inhibited the binding of BaP to the aryl hydrocarbon receptor (AhR), which is the key factor concerning the induction of the CYP1 families.	Benzo(a)pyrene	84-87	aryl hydrocarbon receptor	Homo sapiens	95-120
20553787-11	2010	In addition, the same amounts of chrysoeriol significantly inhibited the binding of BaP to the aryl hydrocarbon receptor (AhR), which is the key factor concerning the induction of the CYP1 families.	Benzo(a)pyrene	84-87	aryl hydrocarbon receptor	Homo sapiens	122-125
20553787-12	2010	In conclusion, our results clearly indicate that chrysoeriol inhibited the formation of BPDE-DNA adducts via regulation of the AhR pathway stimulated by BaP.	Benzo(a)pyrene	153-156	aryl hydrocarbon receptor	Homo sapiens	127-130
20163913-0	2010	CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin.	Benzo(a)pyrene	111-125	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
20163913-0	2010	CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin.	Benzo(a)pyrene	111-125	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	11-17
20435083-0	2010	Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo.	Benzo(a)pyrene	103-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-17
20435083-0	2010	Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo.	Benzo(a)pyrene	103-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-23
20403331-3	2010	Luteolin exposure decreased apical transport of B(a)P metabolites due to its interaction with the transporter breast cancer resistance protein.	Benzo(a)pyrene	48-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	110-142
20185185-0	2010	Benzo[a]pyrene effects on glycine N-methyltransferase mRNA expression and enzyme activity in Fundulus heteroclitus embryos.	Benzo(a)pyrene	0-14	glycine N-methyltransferase	Fundulus heteroclitus	26-53
20185185-7	2010	Whole mount in situ hybridization showed GNMT mRNA expression was increased by BaP in the liver region of 7, 10 and 14dpf F. heteroclitus embryos.	Benzo(a)pyrene	79-82	glycine N-methyltransferase	Fundulus heteroclitus	41-45
20185185-8	2010	In contrast to mRNA induction, in vivo BaP exposure decreased GNMT enzyme activity in 4, 10 and 14dpf embryos.	Benzo(a)pyrene	39-42	glycine N-methyltransferase	Fundulus heteroclitus	62-66
20185185-10	2010	In conclusion, BaP exposure altered GNMT expression, which may represent a new target pathway for BaP-mediated embryonic toxicities and DNA methylation changes.	Benzo(a)pyrene	15-18	glycine N-methyltransferase	Fundulus heteroclitus	36-40
20185185-10	2010	In conclusion, BaP exposure altered GNMT expression, which may represent a new target pathway for BaP-mediated embryonic toxicities and DNA methylation changes.	Benzo(a)pyrene	98-101	glycine N-methyltransferase	Fundulus heteroclitus	36-40
20596254-2	2010	BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations.	Benzo(a)pyrene	0-3	tumor protein p53	Homo sapiens	146-149
20596254-2	2010	BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations.	Benzo(a)pyrene	60-74	tumor protein p53	Homo sapiens	146-149
20596254-2	2010	BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations.	Benzo(a)pyrene	76-79	tumor protein p53	Homo sapiens	146-149
20496344-8	2010	CE-SDS, SDS-cellulose acetate membrane electrophoresis and amino acid compositions indicated that the unknown protein was a highly basic polymer (BP) consisting of basic and phenylalanine-rich oligo-peptide (BOP).	Benzo(a)pyrene	146-148	BOP	Homo sapiens	208-211
20163913-2	2010	Here, we examined the induction and modulation of CYP1A1 and CYP1B1 and 10-(deoxyguanosin-N(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPdG) adduct formation in DNA from 20 primary normal human mammary epithelial cell (NHMEC) strains exposed to BP (4muM) in the absence or presence of chlorophyllin (5muM).	Benzo(a)pyrene	151-153	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
20163913-2	2010	Here, we examined the induction and modulation of CYP1A1 and CYP1B1 and 10-(deoxyguanosin-N(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPdG) adduct formation in DNA from 20 primary normal human mammary epithelial cell (NHMEC) strains exposed to BP (4muM) in the absence or presence of chlorophyllin (5muM).	Benzo(a)pyrene	151-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	61-67
20163913-3	2010	Real-time polymerase chain reaction (RT-PCR) analysis revealed strong induction of both CYP1A1 and CYP1B1 by BP, with high levels of inter-individual variability.	Benzo(a)pyrene	109-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
20163913-3	2010	Real-time polymerase chain reaction (RT-PCR) analysis revealed strong induction of both CYP1A1 and CYP1B1 by BP, with high levels of inter-individual variability.	Benzo(a)pyrene	109-111	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	99-105
20163913-5	2010	Chlorophyllin mitigated BP-induced CYP1A1 and CYP1B1 gene expression in all 20 strains when administered with BP.	Benzo(a)pyrene	24-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	35-41
20163913-5	2010	Chlorophyllin mitigated BP-induced CYP1A1 and CYP1B1 gene expression in all 20 strains when administered with BP.	Benzo(a)pyrene	24-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52
20163913-5	2010	Chlorophyllin mitigated BP-induced CYP1A1 and CYP1B1 gene expression in all 20 strains when administered with BP.	Benzo(a)pyrene	110-112	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52
20504355-1	2010	BACKGROUND: Benzo [a]pyrene (B[a]P) exposure induces DNA adducts at all stages of spermatogenesis and in testis, and removal of these lesions is less efficient in nucleotide excision repair deficient Xpc-/- mice than in wild type mice.	Benzo(a)pyrene	12-27	xeroderma pigmentosum, complementation group C	Mus musculus	200-203
20422711-0	2010	Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells.	Benzo(a)pyrene	0-14	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	22-30
20422711-0	2010	Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells.	Benzo(a)pyrene	0-14	inhibitor of DNA binding 2	Homo sapiens	41-44
20422711-1	2010	Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
20307623-0	2010	Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
20307623-0	2010	Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation.	Benzo(a)pyrene	26-40	aryl hydrocarbon receptor	Homo sapiens	61-86
20307623-2	2010	BaP is known to bind with high specificity to the aryl hydrocarbon receptor (AhR), modifying the expression of CYP1A1, involved both in cancer and inflammation.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	50-75
20307623-2	2010	BaP is known to bind with high specificity to the aryl hydrocarbon receptor (AhR), modifying the expression of CYP1A1, involved both in cancer and inflammation.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	77-80
20307623-2	2010	BaP is known to bind with high specificity to the aryl hydrocarbon receptor (AhR), modifying the expression of CYP1A1, involved both in cancer and inflammation.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-117
20307623-4	2010	AhR and CYP1A1 expression was evaluated by Western blotting, which revealed their presence even in control untreated skin; both enzyme and receptor increased more than twofold after exposure to BaP.	Benzo(a)pyrene	194-197	aryl hydrocarbon receptor	Homo sapiens	0-3
20307623-4	2010	AhR and CYP1A1 expression was evaluated by Western blotting, which revealed their presence even in control untreated skin; both enzyme and receptor increased more than twofold after exposure to BaP.	Benzo(a)pyrene	194-197	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	8-14
20307623-8	2010	The results of this experiment indicate that BaP, an AhR agonist, can significantly increase receptor and CYP1A1 expression and induce oxidative stress in human skin, confirming the involvement of this pathway in the pathogenesis of tissue damage due to polycyclic aromatic hydrocarbons.	Benzo(a)pyrene	45-48	aryl hydrocarbon receptor	Homo sapiens	53-56
20307623-8	2010	The results of this experiment indicate that BaP, an AhR agonist, can significantly increase receptor and CYP1A1 expression and induce oxidative stress in human skin, confirming the involvement of this pathway in the pathogenesis of tissue damage due to polycyclic aromatic hydrocarbons.	Benzo(a)pyrene	45-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	106-112
20228066-3	2010	AhR is an important mediator in the metabolic activation and detoxification of carcinogens, such as the environmental pollutant benzo[a]pyrene (BaP).	Benzo(a)pyrene	128-142	aryl hydrocarbon receptor	Homo sapiens	0-3
20228066-3	2010	AhR is an important mediator in the metabolic activation and detoxification of carcinogens, such as the environmental pollutant benzo[a]pyrene (BaP).	Benzo(a)pyrene	128-142	prohibitin 2	Homo sapiens	144-147
20181698-0	2010	Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene.	Benzo(a)pyrene	155-169	cyclin dependent kinase 1	Homo sapiens	18-22
19961320-1	2010	Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of clinical drugs (e.g., clozapine, tacrine, tizanidine, and theophylline; n &gt; 110), a number of procarcinogens (e.g., benzo[a]pyrene and aromatic amines), and several important endogenous compounds (e.g., steroids).	Benzo(a)pyrene	200-214	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	6-12
20181698-0	2010	Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene.	Benzo(a)pyrene	155-169	cyclin dependent kinase 1	Homo sapiens	23-27
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	RB transcriptional corepressor 1	Homo sapiens	98-101
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase 1	Homo sapiens	134-138
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase 1	Homo sapiens	139-143
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase inhibitor 2A	Homo sapiens	243-246
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase inhibitor 2A	Homo sapiens	247-251
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	interferon alpha inducible protein 27	Homo sapiens	257-260
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase inhibitor 1B	Homo sapiens	261-265
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	RB transcriptional corepressor 1	Homo sapiens	291-294
20181698-8	2010	The addition of purvalanol A, a specific inhibitor of CDK1 kinase, to BaP-treated cultures, resulted in the production of noninfectious HPV type 31b (HPV31b) particles.	Benzo(a)pyrene	70-73	cyclin dependent kinase 1	Homo sapiens	54-58
20181698-10	2010	BaP targeting of CDK1 occurred independently of HPV status, since BaP treatment also increased CDK1 activity in tissues derived from primary keratinocytes.	Benzo(a)pyrene	0-3	cyclin dependent kinase 1	Homo sapiens	17-21
20181698-10	2010	BaP targeting of CDK1 occurred independently of HPV status, since BaP treatment also increased CDK1 activity in tissues derived from primary keratinocytes.	Benzo(a)pyrene	66-69	cyclin dependent kinase 1	Homo sapiens	95-99
20181698-11	2010	Our data indicate that HPV31b virions synthesized in the presence of BaP were dependent on BaP-mediated alteration in CDK1 kinase activity for maintaining their infectivity.	Benzo(a)pyrene	69-72	cyclin dependent kinase 1	Homo sapiens	118-122
20181698-11	2010	Our data indicate that HPV31b virions synthesized in the presence of BaP were dependent on BaP-mediated alteration in CDK1 kinase activity for maintaining their infectivity.	Benzo(a)pyrene	91-94	cyclin dependent kinase 1	Homo sapiens	118-122
20700368-1	2010	PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations.	Benzo(a)pyrene	9-23	tumor protein p53	Homo sapiens	160-163
20700368-1	2010	PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations.	Benzo(a)pyrene	80-94	tumor protein p53	Homo sapiens	160-163
20371965-4	2010	Cotreatment with benzo[a]pyrene (BaP) or 3-methylchoranthrene (3-MC) decreased MDA-LDL-induced THP-1 cell growth, whereas treatment with benzo[e]pyrene (BeP) or pyrene, which is not a ligand for the arylhydrocarbon receptor (AhR), did not decrease THP-1 cell growth.	Benzo(a)pyrene	17-31	aryl hydrocarbon receptor	Homo sapiens	199-223
20371965-4	2010	Cotreatment with benzo[a]pyrene (BaP) or 3-methylchoranthrene (3-MC) decreased MDA-LDL-induced THP-1 cell growth, whereas treatment with benzo[e]pyrene (BeP) or pyrene, which is not a ligand for the arylhydrocarbon receptor (AhR), did not decrease THP-1 cell growth.	Benzo(a)pyrene	17-31	aryl hydrocarbon receptor	Homo sapiens	225-228
20371965-4	2010	Cotreatment with benzo[a]pyrene (BaP) or 3-methylchoranthrene (3-MC) decreased MDA-LDL-induced THP-1 cell growth, whereas treatment with benzo[e]pyrene (BeP) or pyrene, which is not a ligand for the arylhydrocarbon receptor (AhR), did not decrease THP-1 cell growth.	Benzo(a)pyrene	33-36	aryl hydrocarbon receptor	Homo sapiens	199-223
20371965-4	2010	Cotreatment with benzo[a]pyrene (BaP) or 3-methylchoranthrene (3-MC) decreased MDA-LDL-induced THP-1 cell growth, whereas treatment with benzo[e]pyrene (BeP) or pyrene, which is not a ligand for the arylhydrocarbon receptor (AhR), did not decrease THP-1 cell growth.	Benzo(a)pyrene	33-36	aryl hydrocarbon receptor	Homo sapiens	225-228
20371965-6	2010	Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs.	Benzo(a)pyrene	57-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-120
20371965-6	2010	Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs.	Benzo(a)pyrene	57-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	122-129
20371965-6	2010	Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs.	Benzo(a)pyrene	57-60	tumor protein p53	Homo sapiens	210-213
20371965-6	2010	Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs.	Benzo(a)pyrene	57-60	H3 histone pseudogene 16	Homo sapiens	218-221
20371965-7	2010	In support of these findings, AhR small interfering RNA suppressed the induced level of p21 mRNA and by BaP and the overexpression of hCYP1A1 significantly induced levels of p21 mRNA.	Benzo(a)pyrene	104-107	aryl hydrocarbon receptor	Homo sapiens	30-33
20097212-8	2010	While no significant activation of alternative splicing was observed for Fas, CD44 splicing variants were found after BaP treatment.	Benzo(a)pyrene	118-121	CD44 molecule (Indian blood group)	Homo sapiens	78-82
21137059-1	2010	PURPOSE: Previously, we reported that glycine N-methyltransferase (GNMT) interacts with benzo[a]pyrene (BaP) and inhibits BaP-DNA adducts formation.	Benzo(a)pyrene	88-102	glycine N-methyltransferase	Mus musculus	38-65
21137059-1	2010	PURPOSE: Previously, we reported that glycine N-methyltransferase (GNMT) interacts with benzo[a]pyrene (BaP) and inhibits BaP-DNA adducts formation.	Benzo(a)pyrene	88-102	glycine N-methyltransferase	Mus musculus	67-71
21137059-1	2010	PURPOSE: Previously, we reported that glycine N-methyltransferase (GNMT) interacts with benzo[a]pyrene (BaP) and inhibits BaP-DNA adducts formation.	Benzo(a)pyrene	88-102	prohibitin 2	Mus musculus	104-107
19925859-0	2010	MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	95-109	microRNA 320	Mus musculus	0-7
19925859-0	2010	MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	95-109	microRNA 494	Mus musculus	12-19
19925859-3	2010	Here, we cultured primary murine bronchial epithelial cells and then examined the expression of miR-320 and miR-494 in cells exposed to benzo[a]pyrene (B[a]P).	Benzo(a)pyrene	136-150	microRNA 320	Mus musculus	96-103
20064835-2	2010	In order to identify their molecular targets in such cells, we have analyzed gene expression profile of primary human macrophages treated by the prototypical PAH benzo(a)pyrene (BaP), using pangenomic oligonucleotides microarrays.	Benzo(a)pyrene	162-176	prohibitin 2	Homo sapiens	178-181
20654143-1	2010	OBJECTIVE: To investigate cytotoxicity and genotoxicity of benzo(a)pyrene (B(a)P) by 16HBE-CYP1A1 cells which are human bronchial epithelial cell with CYP1A1 transformed.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	91-97
20654143-1	2010	OBJECTIVE: To investigate cytotoxicity and genotoxicity of benzo(a)pyrene (B(a)P) by 16HBE-CYP1A1 cells which are human bronchial epithelial cell with CYP1A1 transformed.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	151-157
20334656-6	2010	Consequently, the effects of benzo [a]pyrene, a prototypic environmental AhR ligand, on plasma cell differentiation could be investigated and this chemical could be exploited essentially as drug probe to implicate the role of the AhR in plasma cell development.	Benzo(a)pyrene	29-44	aryl hydrocarbon receptor	Homo sapiens	73-76
20334656-6	2010	Consequently, the effects of benzo [a]pyrene, a prototypic environmental AhR ligand, on plasma cell differentiation could be investigated and this chemical could be exploited essentially as drug probe to implicate the role of the AhR in plasma cell development.	Benzo(a)pyrene	29-44	aryl hydrocarbon receptor	Homo sapiens	230-233
19896525-1	2010	1,10-phenanthroline (phen), flufenamic acid, and indomethacin are inhibitors of aldo-keto reductases 1C1 (AKR1C1), but only phen decreased the benzo[a]pyrene (BaP)-induced cytochrome P450 1a1 (Cyp1a1) protein level.	Benzo(a)pyrene	159-162	aldo-keto reductase family 1 member C1	Homo sapiens	106-112
19658153-0	2010	K-Ras mutant fraction in A/J mouse lung increases as a function of benzo[a]pyrene dose.	Benzo(a)pyrene	67-81	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-5
19686443-9	2010	Acute rejection, BP medications, and hospitalizations in prior six months had negative association with subsequent eGFR.	Benzo(a)pyrene	17-19	epidermal growth factor receptor	Homo sapiens	115-119
19900515-10	2010	In conclusion, DNA hypermethylation altered and reduced GST-M2 expression that resulted in susceptible to benzo[a]pyrene (B[a]P) induced DNA damage.	Benzo(a)pyrene	106-120	glutathione S-transferase mu 2	Homo sapiens	56-62
20055467-4	2010	In the case of the ET probe, a very strong fluorescence quenching of the BaP-moiety-related emission due to an efficient energy transfer (energy transfer efficiency of about 0.95 for methanol) to the SRB moiety was observed.	Benzo(a)pyrene	73-76	chaperonin containing TCP1 subunit 4	Homo sapiens	200-203
20055467-8	2010	On the basis of these findings, we concluded the following model: the BaP moiety is incorporated in the antibody binding site, whereas the SRB moiety sticks out from the binding site, restricting the motion of the BaP moiety, but leaving the SRB moiety uninfluenced.	Benzo(a)pyrene	214-217	chaperonin containing TCP1 subunit 4	Homo sapiens	139-142
20195826-1	2010	Benzo[a]pyrene (BaP) is a known carcinogen.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
20103645-5	2010	Analysis of skin from wild-type and DKO mice exposed to BP for 6, 12, or 24 hours revealed a relative delay in the activation of p53, p63, p19ARF, and apoptosis in DKO mice, consistent with a negative modifier role for NQO1/NQO2 in carcinogenesis.	Benzo(a)pyrene	56-58	transformation related protein 53, pseudogene	Mus musculus	129-132
20103645-5	2010	Analysis of skin from wild-type and DKO mice exposed to BP for 6, 12, or 24 hours revealed a relative delay in the activation of p53, p63, p19ARF, and apoptosis in DKO mice, consistent with a negative modifier role for NQO1/NQO2 in carcinogenesis.	Benzo(a)pyrene	56-58	transformation related protein 63	Mus musculus	134-137
20103645-5	2010	Analysis of skin from wild-type and DKO mice exposed to BP for 6, 12, or 24 hours revealed a relative delay in the activation of p53, p63, p19ARF, and apoptosis in DKO mice, consistent with a negative modifier role for NQO1/NQO2 in carcinogenesis.	Benzo(a)pyrene	56-58	cyclin dependent kinase inhibitor 2A	Mus musculus	139-145
20103645-5	2010	Analysis of skin from wild-type and DKO mice exposed to BP for 6, 12, or 24 hours revealed a relative delay in the activation of p53, p63, p19ARF, and apoptosis in DKO mice, consistent with a negative modifier role for NQO1/NQO2 in carcinogenesis.	Benzo(a)pyrene	56-58	NAD(P)H dehydrogenase, quinone 1	Mus musculus	219-223
20103645-5	2010	Analysis of skin from wild-type and DKO mice exposed to BP for 6, 12, or 24 hours revealed a relative delay in the activation of p53, p63, p19ARF, and apoptosis in DKO mice, consistent with a negative modifier role for NQO1/NQO2 in carcinogenesis.	Benzo(a)pyrene	56-58	N-ribosyldihydronicotinamide quinone reductase 2	Mus musculus	224-228
19879933-0	2010	Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines.	Benzo(a)pyrene	52-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
19879933-0	2010	Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines.	Benzo(a)pyrene	52-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	25-31
19808042-6	2010	Uncharged tRNA inhibit GTP exchange on eIF2, and free amino acids and insulin inhibit reversible sequestration of F4e by Bp.	Benzo(a)pyrene	121-123	insulin	Homo sapiens	70-77
19896525-2	2010	Therefore the decrease in the BaP-induced Cyp1a1 protein level was not due to inhibition of Akr1c1, but to phen itself.	Benzo(a)pyrene	30-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	42-48
19896525-3	2010	Phen decreased the BaP-induced Cyp1a1 promoter activity and protein expression, and in contrast, it increased Cyp1a1 mRNA, resulting from an increase in mRNA stability.	Benzo(a)pyrene	19-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
19758578-6	2010	In mummichog larvae dosed with 100 microg/L BaP and 100 microg/L benzo[k]fluoranthene, CYP1A protein levels as well as enzyme activity were elevated.	Benzo(a)pyrene	44-47	cytochrome P450 1A1	Fundulus heteroclitus	87-92
20860414-8	2010	Drugs that block the renin-angiotensin-aldosterone system not only provide BP control but may also provide vascular protection and are metabolically neutral.	Benzo(a)pyrene	75-77	renin	Homo sapiens	21-26
20089507-8	2010	CONCLUSIONS: HALT PKD will evaluate potential benefits of rigorous BP control and inhibition of the renin-angiotensin-aldosterone system on kidney disease progression in ADPKD.	Benzo(a)pyrene	67-69	protein kinase D1	Homo sapiens	18-21
20085480-0	2010	Albumin and hemoglobin adducts of benzo[a]pyrene in humans--analytical methods, exposure assessment, and recommendations for future directions.	Benzo(a)pyrene	34-48	albumin	Homo sapiens	0-7
19022425-9	2010	Cigarette smoking and nicotine stimulated the expression of endothelial NO synthase (eNOS) and inducible NO synthase (iNOS) whereas benzo[a]pyrene (BP) only stimulated the expression of eNOS in HES cells.	Benzo(a)pyrene	132-146	nitric oxide synthase 3	Homo sapiens	186-190
19022425-9	2010	Cigarette smoking and nicotine stimulated the expression of endothelial NO synthase (eNOS) and inducible NO synthase (iNOS) whereas benzo[a]pyrene (BP) only stimulated the expression of eNOS in HES cells.	Benzo(a)pyrene	148-150	nitric oxide synthase 3	Homo sapiens	186-190
19917780-5	2010	Transgenic animals overexpressing PRR ubiquitously or selectively in smooth-muscle cells develop high BP or glomerulosclerosis, and increased expression of PRR is reported in models of hypertension or kidney damage.	Benzo(a)pyrene	102-104	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	34-37
19828881-7	2010	In addition, we have identified and characterized 6,2",4"-trimethoxyflavone (TMF) as an AHR ligand that possesses the characteristics of an antagonist having the capacity to compete with agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo[a]pyrene, thus effectively inhibiting AHR-mediated transactivation of a heterologous reporter and endogenous targets, e.g., CYP1A1, independent of cell lineage or species.	Benzo(a)pyrene	245-259	aryl hydrocarbon receptor	Homo sapiens	88-91
19919601-1	2010	Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites.	Benzo(a)pyrene	93-107	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	208-214
19919601-1	2010	Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites.	Benzo(a)pyrene	93-107	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	216-222
19919601-1	2010	Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites.	Benzo(a)pyrene	93-107	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	227-233
19919601-7	2010	Additional experiments indicated that melatonin decreased benzo[a]pyrene hydroxylation catalyzed by hepatic microsomes and CYP1A2 but not by CYP1A1 or CYP1B1.	Benzo(a)pyrene	58-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	123-129
20953119-4	2010	For clinical application, we added aromatic benzene-pyridine (BP-type) analogs to the 3"-overhang region of the RNA-strand and changed the sequences of the passenger strand in the miR-143 duplex (miR-143BPs), leading to greater activity and increased resistance to nuclease.	Benzo(a)pyrene	62-64	microRNA 143	Homo sapiens	180-187
19892394-9	2010	Embryos were also exposed to waterborne BaP at 10 and 100 mug L-1, and by 10 dpf the higher BaP dose caused increased expression of GNMT mRNA.	Benzo(a)pyrene	92-95	glycine N-methyltransferase	Fundulus heteroclitus	132-136
20297673-12	2010	Analyzed in detail is the key significance of the N-terminal site of the B-chain--the linear site of the domain--for binding of IGF-I with BP, functional heterogeneity of its constituent residues, and the characteristic principle of formation of affinity to BP.	Benzo(a)pyrene	139-141	insulin like growth factor 1	Homo sapiens	128-133
20297673-12	2010	Analyzed in detail is the key significance of the N-terminal site of the B-chain--the linear site of the domain--for binding of IGF-I with BP, functional heterogeneity of its constituent residues, and the characteristic principle of formation of affinity to BP.	Benzo(a)pyrene	258-260	insulin like growth factor 1	Homo sapiens	128-133
20015408-9	2009	Application of bp(V), an inhibitor of PTEN that dephosphorylates PIP3, the enzymatic product of PI 3-kinase, promotes parthenogenetic activation of Xenopus eggs.	Benzo(a)pyrene	15-17	phosphatase and tensin homolog L homeolog	Xenopus laevis	38-42
20015408-9	2009	Application of bp(V), an inhibitor of PTEN that dephosphorylates PIP3, the enzymatic product of PI 3-kinase, promotes parthenogenetic activation of Xenopus eggs.	Benzo(a)pyrene	15-17	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	96-107
19403181-10	2009	In contrast, ANF antagonized TCDD and BaP-induced COX-2b and TCDD-induced CYP1C1 expression increases, as well as reduced baseline CYP1B1 and COX-2a expression in liver, while failing to affect BaP and TCDD-induced hepatic CYP1A increases.	Benzo(a)pyrene	38-41	prostaglandin-endoperoxide synthase 2b	Danio rerio	50-56
19889059-0	2009	3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats.	Benzo(a)pyrene	25-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	57-72
19842618-8	2009	Treatment of recombinant NAT2 with the nitrosoarenes, 4-nitrosobiphenyl (4-NO-BP) and 2-nitrosofluorene (2-NO-F), caused rapid and irreversible inactivation of the enzyme by sulfinamide adduct formation with Cys68, but the k(inact)/K(I) values for inactivation of recombinant NAT2 and NAT1 did not indicate significant selectivity for either isoform.	Benzo(a)pyrene	78-80	N-acetyltransferase 2	Homo sapiens	25-29
19842618-8	2009	Treatment of recombinant NAT2 with the nitrosoarenes, 4-nitrosobiphenyl (4-NO-BP) and 2-nitrosofluorene (2-NO-F), caused rapid and irreversible inactivation of the enzyme by sulfinamide adduct formation with Cys68, but the k(inact)/K(I) values for inactivation of recombinant NAT2 and NAT1 did not indicate significant selectivity for either isoform.	Benzo(a)pyrene	78-80	N-acetyltransferase 2	Homo sapiens	276-280
19842618-8	2009	Treatment of recombinant NAT2 with the nitrosoarenes, 4-nitrosobiphenyl (4-NO-BP) and 2-nitrosofluorene (2-NO-F), caused rapid and irreversible inactivation of the enzyme by sulfinamide adduct formation with Cys68, but the k(inact)/K(I) values for inactivation of recombinant NAT2 and NAT1 did not indicate significant selectivity for either isoform.	Benzo(a)pyrene	78-80	N-acetyltransferase 1	Homo sapiens	285-289
19961161-7	2009	When Cyp1a1"s turnover was examined, 1-NP was able to stabilize the 1-NP- and benzo[a]pyrene (BaP)-induced Cyp1a1 mRNA, but not protein.	Benzo(a)pyrene	78-92	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-113
19961161-7	2009	When Cyp1a1"s turnover was examined, 1-NP was able to stabilize the 1-NP- and benzo[a]pyrene (BaP)-induced Cyp1a1 mRNA, but not protein.	Benzo(a)pyrene	94-97	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	5-11
19961161-7	2009	When Cyp1a1"s turnover was examined, 1-NP was able to stabilize the 1-NP- and benzo[a]pyrene (BaP)-induced Cyp1a1 mRNA, but not protein.	Benzo(a)pyrene	94-97	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-113
21217860-5	2009	This HPLC method will be useful for further defining the roles of the CYP1A1 enzyme with both in vitro and in vivo models in understanding its real role in activation and detoxification of BaP.	Benzo(a)pyrene	189-192	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	70-76
19800895-11	2009	Addition of PT or PO increased aldo-keto reductase (AKR1C1/2) levels in the presence of BaP, while cytochrome 1A (CYP1A) mRNA expression and activity were decreased.	Benzo(a)pyrene	88-91	aldo-keto reductase family 1 member C1	Homo sapiens	52-60
19841130-0	2009	Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene.	Benzo(a)pyrene	81-95	APC, WNT signaling pathway regulator	Mus musculus	57-60
19403181-10	2009	In contrast, ANF antagonized TCDD and BaP-induced COX-2b and TCDD-induced CYP1C1 expression increases, as well as reduced baseline CYP1B1 and COX-2a expression in liver, while failing to affect BaP and TCDD-induced hepatic CYP1A increases.	Benzo(a)pyrene	38-41	cytochrome P450, family 1, subfamily C, polypeptide 1	Danio rerio	74-80
19403181-10	2009	In contrast, ANF antagonized TCDD and BaP-induced COX-2b and TCDD-induced CYP1C1 expression increases, as well as reduced baseline CYP1B1 and COX-2a expression in liver, while failing to affect BaP and TCDD-induced hepatic CYP1A increases.	Benzo(a)pyrene	38-41	prostaglandin-endoperoxide synthase 2a	Danio rerio	142-148
19403181-10	2009	In contrast, ANF antagonized TCDD and BaP-induced COX-2b and TCDD-induced CYP1C1 expression increases, as well as reduced baseline CYP1B1 and COX-2a expression in liver, while failing to affect BaP and TCDD-induced hepatic CYP1A increases.	Benzo(a)pyrene	38-41	cytochrome P450, family 1, subfamily A	Danio rerio	223-228
19748547-0	2009	Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	103-117	heat shock protein family A (Hsp70) member 4	Homo sapiens	37-42
19748547-0	2009	Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	103-117	ERCC excision repair 5, endonuclease	Homo sapiens	53-56
19409565-0	2009	Overexpression of antioxidant enzymes in ApoE-deficient mice suppresses benzo(a)pyrene-accelerated atherosclerosis.	Benzo(a)pyrene	72-86	apolipoprotein E	Mus musculus	41-45
19409565-1	2009	The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis.	Benzo(a)pyrene	49-63	prohibitin 2	Mus musculus	65-68
19713357-9	2009	Together, these results suggest that fatty acid hydroperoxides can serve as physiological cofactors in supporting in vivo CYP2S1-catalyzed oxidation of BaP-7,8-diol, and that fatty acid hydroperoxides and CYP2S1 may play important roles in benzo[a]pyrene-induced carcinogenesis.	Benzo(a)pyrene	240-254	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	122-128
19755658-0	2009	The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.	Benzo(a)pyrene	94-108	aryl hydrocarbon receptor nuclear translocator	Mus musculus	4-50
19755658-0	2009	The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.	Benzo(a)pyrene	94-108	aryl hydrocarbon receptor nuclear translocator	Mus musculus	52-56
19755658-1	2009	Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr).	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	43-68
19755658-1	2009	Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr).	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	70-73
19755658-1	2009	Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr).	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	43-68
19755658-1	2009	Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr).	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	70-73
19247804-5	2009	Compare with 16HBE, the PARP1-deficient cells were more sensitive to the damage caused by BaP.	Benzo(a)pyrene	90-93	poly(ADP-ribose) polymerase 1	Homo sapiens	24-29
19247804-8	2009	According to results, we came to the conclusion that PARP1-deficient cells were more sensitive to BaP in contrast to normal 16HBE; DNA repair capacity in PARP1-deficient cells decreased significantly at the early stage of repair, but increased to the equivalent level of normal 16HBE in the later period.	Benzo(a)pyrene	98-101	poly(ADP-ribose) polymerase 1	Homo sapiens	53-58
19247804-8	2009	According to results, we came to the conclusion that PARP1-deficient cells were more sensitive to BaP in contrast to normal 16HBE; DNA repair capacity in PARP1-deficient cells decreased significantly at the early stage of repair, but increased to the equivalent level of normal 16HBE in the later period.	Benzo(a)pyrene	98-101	poly(ADP-ribose) polymerase 1	Homo sapiens	154-159
19247804-9	2009	PARP-1 plays an important role in early repair of DNA damage caused by BaP in 16HBE notwithstanding the main repair work is taken by NER pathway.	Benzo(a)pyrene	71-74	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
19713357-9	2009	Together, these results suggest that fatty acid hydroperoxides can serve as physiological cofactors in supporting in vivo CYP2S1-catalyzed oxidation of BaP-7,8-diol, and that fatty acid hydroperoxides and CYP2S1 may play important roles in benzo[a]pyrene-induced carcinogenesis.	Benzo(a)pyrene	240-254	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	205-211
19726680-10	2009	The levels of hOGG1-dependent DNA strand breaks mediated by B[a]P-7,8-dione were lower in AhR-deficient Hepa and AhR knockdown H358 cells.	Benzo(a)pyrene	60-65	8-oxoguanine DNA glycosylase	Homo sapiens	14-19
19767609-0	2009	Influence of local sequence context on damaged base conformation in human DNA polymerase iota: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion.	Benzo(a)pyrene	161-175	DNA polymerase iota	Homo sapiens	74-93
19726680-10	2009	The levels of hOGG1-dependent DNA strand breaks mediated by B[a]P-7,8-dione were lower in AhR-deficient Hepa and AhR knockdown H358 cells.	Benzo(a)pyrene	60-65	aryl hydrocarbon receptor	Homo sapiens	90-93
19692584-4	2009	tRNA(Sec) has a 9-bp acceptor stem and a 4-bp T stem, in contrast with the 7-bp acceptor stem and the 5-bp T stem in the canonical tRNAs.	Benzo(a)pyrene	18-20	mitochondrially encoded tRNA glycine	Homo sapiens	0-9
19666105-0	2009	Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells.	Benzo(a)pyrene	73-87	catalase	Mus musculus	52-60
19666105-0	2009	Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells.	Benzo(a)pyrene	73-87	aryl-hydrocarbon receptor	Mus musculus	126-151
19666105-1	2009	A reduction in endogenously generated reactive oxygen species in vivo delays benzo(a)pyrene (BaP)-accelerated atherosclerosis, as revealed in hypercholesterolemic mice overexpressing Cu/Zn-superoxide dismutase (SOD) and/or catalase.	Benzo(a)pyrene	77-91	catalase	Mus musculus	223-231
19666105-1	2009	A reduction in endogenously generated reactive oxygen species in vivo delays benzo(a)pyrene (BaP)-accelerated atherosclerosis, as revealed in hypercholesterolemic mice overexpressing Cu/Zn-superoxide dismutase (SOD) and/or catalase.	Benzo(a)pyrene	93-96	catalase	Mus musculus	223-231
19666105-2	2009	To understand the molecular events involved in this protective action, we studied the effects of Cu/Zn-SOD and/or catalase overexpression on BaP detoxification and on aryl hydrocarbon receptor (AhR) expression and its target gene expression in mouse aortic endothelial cells (MAECs).	Benzo(a)pyrene	141-144	catalase	Mus musculus	114-122
19666105-4	2009	After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells.	Benzo(a)pyrene	6-9	aryl-hydrocarbon receptor	Mus musculus	34-37
19666105-4	2009	After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells.	Benzo(a)pyrene	6-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	53-78
19666105-4	2009	After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells.	Benzo(a)pyrene	6-9	superoxide dismutase 1, soluble	Mus musculus	216-225
19666105-4	2009	After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells.	Benzo(a)pyrene	6-9	catalase	Mus musculus	233-241
19666105-4	2009	After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells.	Benzo(a)pyrene	141-144	superoxide dismutase 1, soluble	Mus musculus	216-225
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	17-20	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	29-43
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	17-20	hematopoietic prostaglandin D synthase	Mus musculus	76-101
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	17-20	hematopoietic prostaglandin D synthase	Mus musculus	103-106
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	17-20	glutathione S-transferase, pi 1	Mus musculus	196-201
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	17-20	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	29-35
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	17-20	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	215-221
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	63-66	hematopoietic prostaglandin D synthase	Mus musculus	76-101
19666105-5	2009	In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs.	Benzo(a)pyrene	63-66	hematopoietic prostaglandin D synthase	Mus musculus	103-106
19666105-6	2009	Moreover, knockdown of AhR with RNA interference diminished the Cu/Zn-SOD and catalase enhancement of CYP1A1 expression, GST activity, and BaP detoxification.	Benzo(a)pyrene	139-142	aryl-hydrocarbon receptor	Mus musculus	23-26
19666105-6	2009	Moreover, knockdown of AhR with RNA interference diminished the Cu/Zn-SOD and catalase enhancement of CYP1A1 expression, GST activity, and BaP detoxification.	Benzo(a)pyrene	139-142	superoxide dismutase 1, soluble	Mus musculus	64-73
19666105-6	2009	Moreover, knockdown of AhR with RNA interference diminished the Cu/Zn-SOD and catalase enhancement of CYP1A1 expression, GST activity, and BaP detoxification.	Benzo(a)pyrene	139-142	catalase	Mus musculus	78-86
24031437-1	2009	Benzo [a] Pyrene (BaP) is a highly recalcitrant, polycyclic aromatic hydrocarbon (PAH) with high genotoxicity and carcinogenicity.	Benzo(a)pyrene	0-16	prohibitin 2	Homo sapiens	18-21
19578924-1	2009	The COMT gene is considered as one of the prominent candidate genes for susceptibility to BP, and most studies focused a functional polymorphism in the gene: the Val/Met polymorphism (rs4680).	Benzo(a)pyrene	90-92	catechol-O-methyltransferase	Homo sapiens	4-8
19578924-10	2009	In conclusion, the low-activity allele (Met) of rs4680 in COMT gene possibly confers risk for bipolar disorder in the Han population, while it needs further evidence for concluding its association with BP in the Caucasian population.	Benzo(a)pyrene	202-204	catechol-O-methyltransferase	Homo sapiens	58-62
19687299-3	2009	FoxA1 has a dominant effect in the absence of hormone and induces a cluster of DNase I-hypersensitive sites in the segment comprising bp -400 to +25.	Benzo(a)pyrene	134-136	forkhead box A1	Homo sapiens	0-5
19362414-1	2009	Bagasse pith (BP) has been utilized for activated carbon preparation using H(3)PO(4) (BPH) or KOH (BPK) as a chemical activating agent followed by carbonization at 500 degrees C. The physicochemical properties of activated carbon were carried out.	Benzo(a)pyrene	14-16	Bruton tyrosine kinase	Homo sapiens	99-102
19559082-1	2009	Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	41-55	aryl hydrocarbon receptor	Homo sapiens	159-184
19559082-1	2009	Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	41-55	aryl hydrocarbon receptor	Homo sapiens	186-189
19559082-1	2009	Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	57-60	aryl hydrocarbon receptor	Homo sapiens	159-184
19559082-1	2009	Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	57-60	aryl hydrocarbon receptor	Homo sapiens	186-189
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	62-65	neutrophil cytosolic factor 1	Homo sapiens	130-159
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	62-65	neutrophil cytosolic factor 1	Homo sapiens	161-165
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	62-65	pleckstrin	Homo sapiens	167-170
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	62-65	neutrophil cytosolic factor 1	Homo sapiens	207-211
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	268-271	neutrophil cytosolic factor 1	Homo sapiens	130-159
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	268-271	neutrophil cytosolic factor 1	Homo sapiens	161-165
19559082-2	2009	In the present study, we demonstrated that acute treatment by BaP markedly increased expression of the NADPH oxidase subunit gene neutrophil cytosolic factor 1 (NCF1)/p47(phox) in primary human macrophages; NCF1 was similarly up-regulated in alveolar macrophages from BaP-instilled rats.	Benzo(a)pyrene	268-271	pleckstrin	Homo sapiens	167-170
19559082-3	2009	NCF1 induction in BaP-treated human macrophages was prevented by targeting AhR, through its chemical inhibition or small interference RNA-mediated down-modulation of its expression.	Benzo(a)pyrene	18-21	neutrophil cytosolic factor 1	Homo sapiens	0-4
19559082-3	2009	NCF1 induction in BaP-treated human macrophages was prevented by targeting AhR, through its chemical inhibition or small interference RNA-mediated down-modulation of its expression.	Benzo(a)pyrene	18-21	aryl hydrocarbon receptor	Homo sapiens	75-78
19559082-4	2009	BaP moreover induced activity of the NCF1 promoter sequence, containing a consensus AhR-related xenobiotic-responsive element (XRE), and electrophoretic mobility shift assays and chromatin immunoprecipitation experiments indicated that BaP-triggered binding of AhR to this XRE.	Benzo(a)pyrene	0-3	neutrophil cytosolic factor 1	Homo sapiens	37-41
19559082-4	2009	BaP moreover induced activity of the NCF1 promoter sequence, containing a consensus AhR-related xenobiotic-responsive element (XRE), and electrophoretic mobility shift assays and chromatin immunoprecipitation experiments indicated that BaP-triggered binding of AhR to this XRE.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	84-87
19559082-4	2009	BaP moreover induced activity of the NCF1 promoter sequence, containing a consensus AhR-related xenobiotic-responsive element (XRE), and electrophoretic mobility shift assays and chromatin immunoprecipitation experiments indicated that BaP-triggered binding of AhR to this XRE.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	261-264
19559082-4	2009	BaP moreover induced activity of the NCF1 promoter sequence, containing a consensus AhR-related xenobiotic-responsive element (XRE), and electrophoretic mobility shift assays and chromatin immunoprecipitation experiments indicated that BaP-triggered binding of AhR to this XRE.	Benzo(a)pyrene	236-239	neutrophil cytosolic factor 1	Homo sapiens	37-41
19559082-5	2009	Finally, we showed that BaP exposure resulted in p47(phox) protein translocation to the plasma membrane and in potentiation of phorbol myristate acetate (PMA)-induced superoxide anion production in macrophages.	Benzo(a)pyrene	24-27	pleckstrin	Homo sapiens	49-52
19559082-6	2009	This BaP priming effect toward NADPH oxidase activity was inhibited by the NADPH oxidase specific inhibitor apocynin and the chemical AhR inhibitor alpha-naphtoflavone.	Benzo(a)pyrene	5-8	aryl hydrocarbon receptor	Homo sapiens	134-137
19559082-7	2009	These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases.	Benzo(a)pyrene	29-32	neutrophil cytosolic factor 1	Homo sapiens	41-45
19559082-7	2009	These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases.	Benzo(a)pyrene	29-32	pleckstrin	Homo sapiens	46-49
19559082-7	2009	These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases.	Benzo(a)pyrene	29-32	aryl hydrocarbon receptor	Homo sapiens	161-164
19559082-7	2009	These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases.	Benzo(a)pyrene	29-32	neutrophil cytosolic factor 1	Homo sapiens	191-195
19553035-7	2009	Compared with BaP alone, co-exposure to both BaP and PCB126 significantly enhanced the CYP1A1 activity and the formation of MN but reduced the expression of both XPA and XPC.	Benzo(a)pyrene	45-48	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	170-173
19553035-8	2009	The synergistic effect of PCB126 on BaP-induced MN formation was inhibited by alpha-naphthoflavone (ANF), an inhibitor of CYP1A1.	Benzo(a)pyrene	36-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	122-128
19590965-1	2009	Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens (e.g. benzo[a]pyrene and aflatoxin B(1)), and several important endogenous compounds (e.g. steroids and arachidonic acids).	Benzo(a)pyrene	200-214	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	6-12
19701232-9	2009	n-BP inhibited telomerase activity and hTERT mRNA expression in A549 cells while overexpression of hTERT could abolish BP-induced growth inhibition in the A549 cells.	Benzo(a)pyrene	2-4	telomerase reverse transcriptase	Homo sapiens	39-44
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	Benzo(a)pyrene	198-212	aryl hydrocarbon receptor	Homo sapiens	180-183
19478099-3	2009	Replacement with pharmacologic dosages of vitamin D receptor agonists (VDRA) in animal models of kidney disease consistently show reduction in albuminuria, abrogation of glomerulosclerosis, glomerulomegaly, and glomerular inflammation, effects that may be independent of BP and parathyroid hormone, but the effects of VDRA in preventing tubulointerstitial fibrosis and preventing the progression of kidney failure in these animal models are less clear.	Benzo(a)pyrene	271-273	vitamin D receptor	Homo sapiens	42-60
19486938-4	2009	BP was found to markedly prevent formation of lipid vesicles, cellular lipid accumulation and up-regulation of adipogenic markers such as fatty acid binding protein-4 and glyceraldehyde-3-phosphate dehydrogenase, which represent major hallmarks of human MSC-derived adipocytes.	Benzo(a)pyrene	0-2	fatty acid binding protein 4	Homo sapiens	138-166
19486938-4	2009	BP was found to markedly prevent formation of lipid vesicles, cellular lipid accumulation and up-regulation of adipogenic markers such as fatty acid binding protein-4 and glyceraldehyde-3-phosphate dehydrogenase, which represent major hallmarks of human MSC-derived adipocytes.	Benzo(a)pyrene	0-2	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	171-211
19486938-7	2009	Moreover, BP inhibitory effect toward lipid accumulation in MSC exposed to adipogenic medium was fully counteracted by co-treatment with the AhR antagonist alpha-naphtoflavone.	Benzo(a)pyrene	10-12	aryl hydrocarbon receptor	Homo sapiens	141-144
19486938-8	2009	Taken together, these data indicate that environmental PAHs like BP can likely inhibit human adipogenesis in an AhR-dependent manner.	Benzo(a)pyrene	65-67	aryl hydrocarbon receptor	Homo sapiens	112-115
19214356-0	2009	Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene.	Benzo(a)pyrene	74-88	intercellular adhesion molecule 1	Homo sapiens	27-60
19553035-5	2009	We found that the exposure to BaP or PCB126 alone could effectively increase the CYP1A1 activity and the XPA expression.	Benzo(a)pyrene	30-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	81-87
19553035-5	2009	We found that the exposure to BaP or PCB126 alone could effectively increase the CYP1A1 activity and the XPA expression.	Benzo(a)pyrene	30-33	XPA, DNA damage recognition and repair factor	Homo sapiens	105-108
19553035-7	2009	Compared with BaP alone, co-exposure to both BaP and PCB126 significantly enhanced the CYP1A1 activity and the formation of MN but reduced the expression of both XPA and XPC.	Benzo(a)pyrene	45-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
19553035-7	2009	Compared with BaP alone, co-exposure to both BaP and PCB126 significantly enhanced the CYP1A1 activity and the formation of MN but reduced the expression of both XPA and XPC.	Benzo(a)pyrene	45-48	XPA, DNA damage recognition and repair factor	Homo sapiens	162-165
19358281-2	2009	Benzo[a]pyrene (BaP), an AhR agonist, increased FGF-9 expression in human lung adenocarcinoma cells.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	25-28
19358281-2	2009	Benzo[a]pyrene (BaP), an AhR agonist, increased FGF-9 expression in human lung adenocarcinoma cells.	Benzo(a)pyrene	0-14	fibroblast growth factor 9	Homo sapiens	48-53
19358281-2	2009	Benzo[a]pyrene (BaP), an AhR agonist, increased FGF-9 expression in human lung adenocarcinoma cells.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	25-28
19358281-2	2009	Benzo[a]pyrene (BaP), an AhR agonist, increased FGF-9 expression in human lung adenocarcinoma cells.	Benzo(a)pyrene	16-19	fibroblast growth factor 9	Homo sapiens	48-53
19358281-3	2009	Similarly, several AhR agonists increased FGF-9 mRNA levels, and BaP-induced FGF-9 expression was prevented by cotreatment with AhR antagonist in human lung adenocarcinoma cells.	Benzo(a)pyrene	65-68	aryl hydrocarbon receptor	Homo sapiens	19-22
19358281-3	2009	Similarly, several AhR agonists increased FGF-9 mRNA levels, and BaP-induced FGF-9 expression was prevented by cotreatment with AhR antagonist in human lung adenocarcinoma cells.	Benzo(a)pyrene	65-68	fibroblast growth factor 9	Homo sapiens	77-82
19358281-3	2009	Similarly, several AhR agonists increased FGF-9 mRNA levels, and BaP-induced FGF-9 expression was prevented by cotreatment with AhR antagonist in human lung adenocarcinoma cells.	Benzo(a)pyrene	65-68	aryl hydrocarbon receptor	Homo sapiens	128-131
19358281-5	2009	Modulation of AhR expression via RNA interference or transient overexpression respectively reduced or increased both constitutive and BaP-induced FGF-9 expression in human lung cells.	Benzo(a)pyrene	134-137	aryl hydrocarbon receptor	Homo sapiens	14-17
19358281-5	2009	Modulation of AhR expression via RNA interference or transient overexpression respectively reduced or increased both constitutive and BaP-induced FGF-9 expression in human lung cells.	Benzo(a)pyrene	134-137	fibroblast growth factor 9	Homo sapiens	146-151
19542228-1	2009	Human polymerase kappa (hPol kappa) is one of four eukaryotic Y-class DNA polymerases and may be an important element in the cellular response to polycyclic aromatic hydrocarbons such as benzo[a]pyrene, which can lead to reactive oxygenated metabolite-mediated oxidative stress.	Benzo(a)pyrene	187-201	DNA polymerase lambda	Homo sapiens	24-34
19397966-1	2009	Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	144-147
19397966-1	2009	Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation.	Benzo(a)pyrene	16-18	tumor protein p53	Homo sapiens	144-147
19397966-3	2009	Here we have analyzed the effects of BP on p53 related apoptotic proteins, cell cycle and cell death in MCF-7 cells.	Benzo(a)pyrene	37-39	tumor protein p53	Homo sapiens	43-46
19397966-4	2009	PUMA-protein (p53 up-regulated modulator of apoptosis) levels were changed after BP exposure so that PUMA-alpha protein was statistically significantly increased whereas PUMA-beta protein was statistically significantly decreased.	Benzo(a)pyrene	81-83	tumor protein p53	Homo sapiens	14-17
19397966-6	2009	Cytochrome c, which is released from mitochondria during apoptosis to form the apoptosome, was increased in cytoplasmic fraction after BP exposure in MCF-7 cells.	Benzo(a)pyrene	135-137	cytochrome c, somatic	Homo sapiens	0-12
19397966-9	2009	Our results suggest that PUMA-alpha protein is involved in BP-induced cell death most likely through a p53 dependent apoptotic pathway.	Benzo(a)pyrene	59-61	tumor protein p53	Homo sapiens	103-106
19463884-1	2009	Pyrene, benzo[a]pyrene (BaP), and indeno[1,2,3-cd]pyrene (IND) are poly cyclic aromatic hydrocarbons (PAHs) with four to six annealed phenyl rings.	Benzo(a)pyrene	8-22	prohibitin 2	Homo sapiens	24-27
18767135-4	2009	Benzo(a)pyrene (BaP) can cause a variety of toxicities in vitro, such as oxidative DNA damage and genotoxicity.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
19638449-11	2009	These Cul3-silenced MCF7 cells are highly resistant to oxidative stress induced by H(2)O(2,) to the carcinogen benzo(a)pyrene, and to both Doxorubicin and Paclitaxel.	Benzo(a)pyrene	111-125	cullin 3	Homo sapiens	6-10
19406224-7	2009	Gene expression analysis at 4 and 24h following benzo(a)pyrene exposure revealed the induction of cyp1a1, cyp1a2, and cyp1b1 in FE1 cells and lung isolates.	Benzo(a)pyrene	48-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104
19406224-7	2009	Gene expression analysis at 4 and 24h following benzo(a)pyrene exposure revealed the induction of cyp1a1, cyp1a2, and cyp1b1 in FE1 cells and lung isolates.	Benzo(a)pyrene	48-62	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	106-112
19406224-7	2009	Gene expression analysis at 4 and 24h following benzo(a)pyrene exposure revealed the induction of cyp1a1, cyp1a2, and cyp1b1 in FE1 cells and lung isolates.	Benzo(a)pyrene	48-62	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	118-124
19464357-0	2009	Claspin is involved in S-phase checkpoint induced by benzo(a)pyrene in 16HBE cells.	Benzo(a)pyrene	53-67	claspin	Homo sapiens	0-7
19464357-3	2009	In the present study we have investigated the role of human Claspin in the DNA damage checkpoint elicited by BaP in 16HBE cells.	Benzo(a)pyrene	109-112	claspin	Homo sapiens	60-67
19497421-3	2009	The present study aimed to characterize expression/activities of enzymes of two major pathways involved in the metabolism of benzo[a]pyrene (BaP): cytochrome P450 (CYP) family 1 enzymes and cytosolic aldo-keto reductases (AKRs).	Benzo(a)pyrene	125-139	prohibitin 2	Rattus norvegicus	141-144
19214356-4	2009	This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1.	Benzo(a)pyrene	69-74	intercellular adhesion molecule 1	Homo sapiens	83-89
20449226-6	2009	The concentrations of benzo(a)pyrene (Bap), the best index for PAHs carcinogenicity, were higher in indoor air than that in outdoor air.	Benzo(a)pyrene	22-36	prohibitin 2	Homo sapiens	38-41
19181443-0	2009	Benzo[a]pyrene promotes proliferation of human lung cancer cells by accelerating the epidermal growth factor receptor signaling pathway.	Benzo(a)pyrene	0-14	epidermal growth factor receptor	Homo sapiens	85-117
19530133-0	2009	Genetic regulatory networks of nephrogenesis: deregulation of WT1 splicing by benzo(a)pyrene.	Benzo(a)pyrene	78-92	WT1 transcription factor	Homo sapiens	62-65
18655176-0	2009	Molecular cloning of CYP1A gene and its expression by benzo(a)pyrene from goldfish (Carassius auratus).	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily A	Danio rerio	21-26
18655176-4	2009	Exposure to benzo(a)pyrene (BaP) by intraperitoneal injection increased biliary BaP metabolites and liver CYP1A gene expression.	Benzo(a)pyrene	12-26	cytochrome P450, family 1, subfamily A	Danio rerio	106-111
18655176-4	2009	Exposure to benzo(a)pyrene (BaP) by intraperitoneal injection increased biliary BaP metabolites and liver CYP1A gene expression.	Benzo(a)pyrene	28-31	cytochrome P450, family 1, subfamily A	Danio rerio	106-111
18655176-5	2009	BaP exposure also increased CYP1A gene expression in extrahepatic organs, including intestine, and gill, which are sensitive to aqueous and dietary exposure to Arylhydrocarbon receptor (AhR) agonists.	Benzo(a)pyrene	0-3	cytochrome P450, family 1, subfamily A	Danio rerio	28-33
19228760-3	2009	Therefore, we tested the hypothesis that mainstream cigarette smoke and a cigarette smoke constituent, benzo[a]pyrene (BaP), induce apoptosis in ovarian follicles.	Benzo(a)pyrene	103-117	prohibitin 2	Mus musculus	119-122
19302510-5	2009	The median concentration of PAH ranged from 0.14 (lowest, anthracene) to 31.18 microg g(-1) [dibenz(a,h)anthracene] in kajal sample and from not detectable concentration (naphthalene) to 197.47 microg g(-1) of benzo(a)pyrene in surma sample.	Benzo(a)pyrene	210-224	phenylalanine hydroxylase	Homo sapiens	28-31
19501186-6	2009	Among these transformants, benzo(a)pyrene-induced or cyclophosphamide-produced micronucleus (MN) frequency was markedly increased in transformants expressing CYP1A2 or CYP2C9, respectively.	Benzo(a)pyrene	27-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	158-164
19344691-0	2009	Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.	Benzo(a)pyrene	15-29	proliferating cell nuclear antigen	Nicotiana tabacum	64-68
19429241-1	2009	We have previously shown that benzo[a]pyrene (B[a]P) administrated at extremely low dose can cause weight gain in mice and that the increase in adipose tissue mass is due to inhibition of beta-adrenergic stimulation of lipolysis.	Benzo(a)pyrene	30-44	WD and tetratricopeptide repeats 1	Mus musculus	144-151
19330882-0	2009	Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.	Benzo(a)pyrene	86-100	glutathione S-transferase pi 1	Homo sapiens	33-61
19269699-0	2009	Effect of CYP1A inhibition on the biotransformation of benzo[a]pyrene in two populations of Fundulus heteroclitus with different exposure histories.	Benzo(a)pyrene	55-69	cytochrome P450 1A1	Fundulus heteroclitus	10-15
19269699-9	2009	Two of the abundant PAHs at the ER are fluoranthene (FL), a CYP1A inhibitor, and benzo[a]pyrene (BaP), a CYP1A inducer.	Benzo(a)pyrene	81-95	cytochrome P450 1A1	Fundulus heteroclitus	105-110
19269699-9	2009	Two of the abundant PAHs at the ER are fluoranthene (FL), a CYP1A inhibitor, and benzo[a]pyrene (BaP), a CYP1A inducer.	Benzo(a)pyrene	97-100	cytochrome P450 1A1	Fundulus heteroclitus	105-110
19501186-6	2009	Among these transformants, benzo(a)pyrene-induced or cyclophosphamide-produced micronucleus (MN) frequency was markedly increased in transformants expressing CYP1A2 or CYP2C9, respectively.	Benzo(a)pyrene	27-41	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	168-174
19131362-3	2009	METHODS AND RESULTS: Exposure of primary human macrophages to TCDD and BP decreased NPC1 mRNA expression in a time-dependent manner.	Benzo(a)pyrene	71-73	NPC intracellular cholesterol transporter 1	Homo sapiens	84-88
19131362-5	2009	NPC1 was also similarly down-regulated in mice exposed to BP.	Benzo(a)pyrene	58-60	NPC intracellular cholesterol transporter 1	Mus musculus	0-4
19131362-10	2009	CONCLUSION: Our data have shown that contaminants such as TCDD and BP repress NPC1 expression in macrophages in an AHR-dependent manner, which likely contributes to macrophage lipid accumulation caused by these environmental chemicals.	Benzo(a)pyrene	67-69	NPC intracellular cholesterol transporter 1	Homo sapiens	78-82
19131362-10	2009	CONCLUSION: Our data have shown that contaminants such as TCDD and BP repress NPC1 expression in macrophages in an AHR-dependent manner, which likely contributes to macrophage lipid accumulation caused by these environmental chemicals.	Benzo(a)pyrene	67-69	aryl hydrocarbon receptor	Homo sapiens	115-118
19236443-12	2009	Improvements in the insulin delivery technique might allow to optimize drug application in all cases with even higher BA/BP with RHIIP.	Benzo(a)pyrene	121-123	insulin	Homo sapiens	20-27
19244278-11	2009	Thus, AhR activation by BaP stimulates vitamin D3 catabolism.	Benzo(a)pyrene	24-27	aryl hydrocarbon receptor	Homo sapiens	6-9
19413655-3	2009	Benzo(a)pyrene-induced lung cancer-bearing animals showed abnormal changes in body weight, lung weight, tumour incidence and alterations in the activities of marker enzymes adenosine deaminase, aryl hydrocarbon hydroxylase, gamma-glutamyl transpeptidase, 5"-nucleotidase and lactate dehydrogenase.	Benzo(a)pyrene	0-14	adenosine deaminase	Mus musculus	173-192
19413655-3	2009	Benzo(a)pyrene-induced lung cancer-bearing animals showed abnormal changes in body weight, lung weight, tumour incidence and alterations in the activities of marker enzymes adenosine deaminase, aryl hydrocarbon hydroxylase, gamma-glutamyl transpeptidase, 5"-nucleotidase and lactate dehydrogenase.	Benzo(a)pyrene	0-14	5' nucleotidase, ecto	Mus musculus	255-270
19651790-7	2009	This article reviews experimental evidence that environmental pollutants (such as benzo[a]pyrene (BaP), a commonly used index of environmental pollution) are photosensitizers that generate reactive oxygen species (ROS) when exposed to UVA radiation.	Benzo(a)pyrene	82-96	prohibitin 2	Homo sapiens	98-101
19386251-1	2009	Benzo(a)pyrene (BaP) is a representative environmental carcinogen and is metabolically activated by several cytochrome P450 (CYP) enzymes to become the ultimate carcinogen.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
19245359-3	2009	In this study we have investigated data from different platforms and laboratories on the transcriptomic profile of HepG2 cells exposed to benzo(a)pyrene (BaP).	Benzo(a)pyrene	138-152	prohibitin 2	Homo sapiens	154-157
19244278-0	2009	The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.	Benzo(a)pyrene	40-54	aryl hydrocarbon receptor	Homo sapiens	4-29
19244278-4	2009	BaP effectively enhanced the 1,25(OH)2D3-dependent induction of cytochrome P450 24A1 (CYP24A1) in human monocyte/macrophage-derived THP-1 cells and breast cancer MCF-7 cells.	Benzo(a)pyrene	0-3	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	64-84
19244278-4	2009	BaP effectively enhanced the 1,25(OH)2D3-dependent induction of cytochrome P450 24A1 (CYP24A1) in human monocyte/macrophage-derived THP-1 cells and breast cancer MCF-7 cells.	Benzo(a)pyrene	0-3	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	86-93
19244278-5	2009	BaP combination was less or not effective on mRNA expression of CD14, arachidonate 5-lipoxygenase, and cathelicidin antimicrobial peptide in THP-1 cells.	Benzo(a)pyrene	0-3	cathelicidin antimicrobial peptide	Homo sapiens	103-137
19244278-6	2009	BaP also increased the expression of CYP24A1 induced by a non-vitamin D VDR ligand, lithocholic acid acetate.	Benzo(a)pyrene	0-3	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44
19244278-6	2009	BaP also increased the expression of CYP24A1 induced by a non-vitamin D VDR ligand, lithocholic acid acetate.	Benzo(a)pyrene	0-3	vitamin D receptor	Homo sapiens	72-75
19244278-8	2009	Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing effect of BaP on CYP24A1 induction, indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis.	Benzo(a)pyrene	110-113	aryl hydrocarbon receptor	Homo sapiens	27-30
19244278-8	2009	Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing effect of BaP on CYP24A1 induction, indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis.	Benzo(a)pyrene	110-113	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
19244278-8	2009	Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing effect of BaP on CYP24A1 induction, indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis.	Benzo(a)pyrene	110-113	aryl hydrocarbon receptor	Homo sapiens	187-190
19244278-8	2009	Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing effect of BaP on CYP24A1 induction, indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis.	Benzo(a)pyrene	167-170	aryl hydrocarbon receptor	Homo sapiens	27-30
19244278-8	2009	Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing effect of BaP on CYP24A1 induction, indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis.	Benzo(a)pyrene	167-170	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
19244278-8	2009	Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing effect of BaP on CYP24A1 induction, indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis.	Benzo(a)pyrene	167-170	aryl hydrocarbon receptor	Homo sapiens	187-190
19244278-9	2009	BaP pretreatment increased 1,25(OH)2D3-dependent recruitment of VDR and retinoid X receptor to the CYP24A1 promoter.	Benzo(a)pyrene	0-3	vitamin D receptor	Homo sapiens	64-67
19244278-9	2009	BaP pretreatment increased 1,25(OH)2D3-dependent recruitment of VDR and retinoid X receptor to the CYP24A1 promoter.	Benzo(a)pyrene	0-3	retinoid X receptor alpha	Homo sapiens	72-91
19244278-9	2009	BaP pretreatment increased 1,25(OH)2D3-dependent recruitment of VDR and retinoid X receptor to the CYP24A1 promoter.	Benzo(a)pyrene	0-3	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	99-106
19244278-10	2009	Analysis of 1,25(OH)2D3 metabolism showed that BaP enhanced the hydroxylation of 1,25(OH)2D3 by CYP24A1 in THP-1 cells.	Benzo(a)pyrene	47-50	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	96-103
19253337-7	2009	MTBITC suppressed MN formation in B(a)P-treated cells to the background level at a concentration of 1 muM.	Benzo(a)pyrene	34-39	latexin	Homo sapiens	102-105
19302817-8	2009	Co-exposure to Lp(a) and the AhR ligand benzo(a)pyrene was finally shown to superinduce CCL1 expression in human macrophages, supporting the conclusion that Lp(a) and AhR ligands act on CCL1 through independent ways.	Benzo(a)pyrene	40-54	aryl hydrocarbon receptor	Homo sapiens	29-32
19302817-8	2009	Co-exposure to Lp(a) and the AhR ligand benzo(a)pyrene was finally shown to superinduce CCL1 expression in human macrophages, supporting the conclusion that Lp(a) and AhR ligands act on CCL1 through independent ways.	Benzo(a)pyrene	40-54	C-C motif chemokine ligand 1	Homo sapiens	88-92
19302817-8	2009	Co-exposure to Lp(a) and the AhR ligand benzo(a)pyrene was finally shown to superinduce CCL1 expression in human macrophages, supporting the conclusion that Lp(a) and AhR ligands act on CCL1 through independent ways.	Benzo(a)pyrene	40-54	lipoprotein(a)	Homo sapiens	157-162
19302817-8	2009	Co-exposure to Lp(a) and the AhR ligand benzo(a)pyrene was finally shown to superinduce CCL1 expression in human macrophages, supporting the conclusion that Lp(a) and AhR ligands act on CCL1 through independent ways.	Benzo(a)pyrene	40-54	aryl hydrocarbon receptor	Homo sapiens	167-170
19302817-8	2009	Co-exposure to Lp(a) and the AhR ligand benzo(a)pyrene was finally shown to superinduce CCL1 expression in human macrophages, supporting the conclusion that Lp(a) and AhR ligands act on CCL1 through independent ways.	Benzo(a)pyrene	40-54	C-C motif chemokine ligand 1	Homo sapiens	186-190
19351592-0	2009	Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor.	Benzo(a)pyrene	47-61	aryl-hydrocarbon receptor	Mus musculus	91-116
19351592-1	2009	We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis.	Benzo(a)pyrene	35-49	aryl-hydrocarbon receptor	Mus musculus	112-137
19351592-1	2009	We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis.	Benzo(a)pyrene	35-49	aryl-hydrocarbon receptor	Mus musculus	139-142
19351592-1	2009	We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis.	Benzo(a)pyrene	51-56	aryl-hydrocarbon receptor	Mus musculus	112-137
19351592-1	2009	We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis.	Benzo(a)pyrene	51-56	aryl-hydrocarbon receptor	Mus musculus	139-142
19216581-0	2009	Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure.	Benzo(a)pyrene	21-35	aryl-hydrocarbon receptor	Mus musculus	39-42
19216581-2	2009	The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis.	Benzo(a)pyrene	66-68	aryl-hydrocarbon receptor	Mus musculus	4-15
19216581-2	2009	The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis.	Benzo(a)pyrene	66-68	aryl-hydrocarbon receptor	Mus musculus	17-20
19216581-2	2009	The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis.	Benzo(a)pyrene	97-99	aryl-hydrocarbon receptor	Mus musculus	4-15
19216581-2	2009	The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis.	Benzo(a)pyrene	97-99	aryl-hydrocarbon receptor	Mus musculus	17-20
19216581-7	2009	On the other hand, the Ahr(-/-) mice appear to have a lower metabolic clearance of BP resulting in increased levels of DNA and protein adducts and of unmetabolized BP.	Benzo(a)pyrene	83-85	aryl-hydrocarbon receptor	Mus musculus	23-26
19216581-7	2009	On the other hand, the Ahr(-/-) mice appear to have a lower metabolic clearance of BP resulting in increased levels of DNA and protein adducts and of unmetabolized BP.	Benzo(a)pyrene	164-166	aryl-hydrocarbon receptor	Mus musculus	23-26
19216581-9	2009	In addition, the systemic uptake of BP is increased in the Ahr(-/-) mice as compared with the wild-type mice.	Benzo(a)pyrene	36-38	aryl-hydrocarbon receptor	Mus musculus	59-62
19216581-10	2009	Hence, the lack of a functional Ah receptor results in an Ahr-independent biotransformation of BP with a slower clearance of BP and higher levels of DNA and protein adducts, but the distribution and levels of BP and BP-protein adducts are clearly dependent on the route of exposure.	Benzo(a)pyrene	95-97	aryl-hydrocarbon receptor	Mus musculus	32-43
19216581-10	2009	Hence, the lack of a functional Ah receptor results in an Ahr-independent biotransformation of BP with a slower clearance of BP and higher levels of DNA and protein adducts, but the distribution and levels of BP and BP-protein adducts are clearly dependent on the route of exposure.	Benzo(a)pyrene	95-97	aryl-hydrocarbon receptor	Mus musculus	58-61
19103175-10	2009	The results presented in this study suggest adiponectin acts in the NTS to control BP and suggest that such effects may occur as a direct result of the ability of this adipokine to modulate the excitability of discrete groups of neurons in the NTS.	Benzo(a)pyrene	83-85	adiponectin, C1Q and collagen domain containing	Homo sapiens	44-55
19146932-2	2009	Here we show that expression of Smoc2 is repressed in cultured cells following treatment with Aryl-hydrocarbon receptor (Ahr) ligands including the ubiquitous environmental pollutants Benzo[a]pyrene (B[a]P) and 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD).	Benzo(a)pyrene	184-198	SPARC related modular calcium binding 2	Mus musculus	32-37
19084306-1	2009	In this study, three different soils with contrasting features, spiked with 300 mg benzo[a]pyrene (BaP)/kg dry soil, were incubated at 20 degrees C and 60% water holding capacity for 540 days.	Benzo(a)pyrene	83-97	prohibitin 2	Homo sapiens	99-102
19152381-7	2009	Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, &gt;85% for CYP1A1 and &gt;70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group.	Benzo(a)pyrene	77-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
19152381-7	2009	Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, &gt;85% for CYP1A1 and &gt;70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group.	Benzo(a)pyrene	77-79	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	140-146
19152381-11	2009	Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced.	Benzo(a)pyrene	35-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
19152381-11	2009	Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced.	Benzo(a)pyrene	35-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	90-96
19718808-3	2009	The BP conjugates of OPG were shown to display a higher hydroxyapatite affinity in vitro as compared to unmodified OPG.	Benzo(a)pyrene	4-6	TNF receptor superfamily member 11B	Rattus norvegicus	21-24
19718808-3	2009	The BP conjugates of OPG were shown to display a higher hydroxyapatite affinity in vitro as compared to unmodified OPG.	Benzo(a)pyrene	4-6	TNF receptor superfamily member 11B	Rattus norvegicus	115-118
19718808-5	2009	Furthermore, the retention of the OPG-thiolBP conjugate was significantly higher after 72 h. When administered to osteoarthritic rats undergoing active bone remodeling, the delivery of OPG-thiolBP conjugate to bone was increased more than 4-fold over that of control OPG after 24 h. These results suggest a significant advantage of BP conjugation as a drug delivery strategy for therapeutic cytokines in osteopenic bone diseases.	Benzo(a)pyrene	43-45	TNF receptor superfamily member 11B	Rattus norvegicus	34-37
19718808-5	2009	Furthermore, the retention of the OPG-thiolBP conjugate was significantly higher after 72 h. When administered to osteoarthritic rats undergoing active bone remodeling, the delivery of OPG-thiolBP conjugate to bone was increased more than 4-fold over that of control OPG after 24 h. These results suggest a significant advantage of BP conjugation as a drug delivery strategy for therapeutic cytokines in osteopenic bone diseases.	Benzo(a)pyrene	43-45	TNF receptor superfamily member 11B	Rattus norvegicus	185-188
19718808-5	2009	Furthermore, the retention of the OPG-thiolBP conjugate was significantly higher after 72 h. When administered to osteoarthritic rats undergoing active bone remodeling, the delivery of OPG-thiolBP conjugate to bone was increased more than 4-fold over that of control OPG after 24 h. These results suggest a significant advantage of BP conjugation as a drug delivery strategy for therapeutic cytokines in osteopenic bone diseases.	Benzo(a)pyrene	43-45	TNF receptor superfamily member 11B	Rattus norvegicus	185-188
19534924-1	2009	OBJECTIVE: To investigate Benzo (a) pyrene (BaP) residue in retail food of Xiamen.	Benzo(a)pyrene	26-42	prohibitin 2	Homo sapiens	44-47
19027820-0	2009	Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.	Benzo(a)pyrene	60-74	cyclin A2	Homo sapiens	0-8
19027820-0	2009	Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.	Benzo(a)pyrene	60-74	tumor protein p53	Homo sapiens	30-33
19027820-8	2009	These results indicated that cyclin A is regulated by p53, not by B(a)P, and it is essential in the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells, cyclin E and p21 also as downstream genes of p53 involved it, which is p27-independent.	Benzo(a)pyrene	130-144	cyclin A2	Homo sapiens	29-37
19027820-8	2009	These results indicated that cyclin A is regulated by p53, not by B(a)P, and it is essential in the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells, cyclin E and p21 also as downstream genes of p53 involved it, which is p27-independent.	Benzo(a)pyrene	130-144	tumor protein p53	Homo sapiens	100-103
19027820-8	2009	These results indicated that cyclin A is regulated by p53, not by B(a)P, and it is essential in the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells, cyclin E and p21 also as downstream genes of p53 involved it, which is p27-independent.	Benzo(a)pyrene	130-144	tumor protein p53	Homo sapiens	100-103
18636242-7	2009	A strong, concentration-dependent CYP1A1 induction was observed in the responsive subpopulation when incubated with benzo[a]pyrene (B[a]P) in a concentration range between 1 and 10 muM.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily A member 1	Sus scrofa	34-40
19218474-4	2009	Epo increases BP directly and notably independently of its erythropoietic effect and its effect on blood rheology.	Benzo(a)pyrene	14-16	erythropoietin	Homo sapiens	0-3
18534687-10	2009	CONCLUSIONS: The 5-HTTLPR polymorphism may be considered a predictor of abnormal response to antidepressant in patients with BP, but this action is influenced by the presence of a mood stabilizer.	Benzo(a)pyrene	125-127	solute carrier family 6 member 4	Homo sapiens	17-25
18848825-0	2009	H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides.	Benzo(a)pyrene	82-96	H2A.X variant histone	Homo sapiens	0-4
19791837-2	2009	A number of interventional trials have shown that these patients benefit greatly from aggressive BP lowering, especially when the drug regimen comprises an inhibitor of the renin-angiotensin system.	Benzo(a)pyrene	97-99	renin	Homo sapiens	173-178
18802434-12	2009	If the concept of that treatment resistance is caused by excessive reactive increases in renin secretion is confirmed, then a PRA determination during treatment could be used to guide subsequent addition or subtraction of either natriuretic or antirenin drug types, to thereby correct BP and reduce cardiovascular risk.	Benzo(a)pyrene	285-287	renin	Homo sapiens	89-94
19503771-6	2009	Osteocalcin level showed an over 65% increase in group B but both RCE and RCE + BP treatments prevented such abnormality with a significantly better result in RCE + BP group which virtually normalized such parameter as well as urinary excretion of DPD.	Benzo(a)pyrene	80-82	dihydropyrimidine dehydrogenase	Rattus norvegicus	248-251
19503771-6	2009	Osteocalcin level showed an over 65% increase in group B but both RCE and RCE + BP treatments prevented such abnormality with a significantly better result in RCE + BP group which virtually normalized such parameter as well as urinary excretion of DPD.	Benzo(a)pyrene	165-167	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-11
19503771-6	2009	Osteocalcin level showed an over 65% increase in group B but both RCE and RCE + BP treatments prevented such abnormality with a significantly better result in RCE + BP group which virtually normalized such parameter as well as urinary excretion of DPD.	Benzo(a)pyrene	165-167	dihydropyrimidine dehydrogenase	Rattus norvegicus	248-251
19157061-3	2009	The focus of this present review lies on the influence of the molecular structure of two well-investigated chemical carcinogens from the group of polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP).	Benzo(a)pyrene	203-205	D-box binding PAR bZIP transcription factor	Homo sapiens	231-234
19202560-0	2009	Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.	Benzo(a)pyrene	77-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
19202560-0	2009	Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.	Benzo(a)pyrene	77-91	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
19202560-6	2009	The aim of the study was to determine whether the differences in the isothiocyanate structure change its ability to inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene in HepG2 and Mcf7 cells.	Benzo(a)pyrene	162-176	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	124-130
19202560-6	2009	The aim of the study was to determine whether the differences in the isothiocyanate structure change its ability to inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene in HepG2 and Mcf7 cells.	Benzo(a)pyrene	162-176	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	135-141
21179917-3	2009	The BP level target, unanimously considered a very important element of HBP management, must not be the only one.	Benzo(a)pyrene	4-6	high density lipoprotein binding protein	Homo sapiens	72-75
19334494-7	2009	CCK after standard meal significantly rose both in AP and BP.	Benzo(a)pyrene	58-60	cholecystokinin	Homo sapiens	0-3
18989657-0	2008	Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes.	Benzo(a)pyrene	33-47	aryl hydrocarbon receptor	Homo sapiens	64-75
18787751-3	2008	Significant correlations between benzo(a)pyrene (BaP) metabolites and hexachlorobenzene (HCB) with Vtg and E(2) were found.	Benzo(a)pyrene	33-47	vitellogenin	Oreochromis niloticus	99-102
18787751-3	2008	Significant correlations between benzo(a)pyrene (BaP) metabolites and hexachlorobenzene (HCB) with Vtg and E(2) were found.	Benzo(a)pyrene	49-52	vitellogenin	Oreochromis niloticus	99-102
18840388-2	2008	The coexposure of CYP1A inhibitors (e.g. FL or ANF) with AHR agonists (e.g. BaP or BNF) results in a synergistic increase in toxicity.	Benzo(a)pyrene	76-79	cytochrome P450, family 1, subfamily A	Danio rerio	18-23
18840388-2	2008	The coexposure of CYP1A inhibitors (e.g. FL or ANF) with AHR agonists (e.g. BaP or BNF) results in a synergistic increase in toxicity.	Benzo(a)pyrene	76-79	natriuretic peptide A	Danio rerio	47-50
18840388-4	2008	We hypothesized that a hypoxia-induced reduction in CYP1A activity in BNF or BaP-exposed zebrafish embryos would similarly enhance pericardial effusion and other developmental abnormalities.	Benzo(a)pyrene	77-80	cytochrome P450, family 1, subfamily A	Danio rerio	52-57
18840388-6	2008	CYP1A activity in the BaP+hypoxia and BNF+hypoxia embryos was reduced by approximately 60% relative to normoxia embryos.	Benzo(a)pyrene	22-25	cytochrome P450, family 1, subfamily A	Danio rerio	0-5
18671994-0	2008	Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway.	Benzo(a)pyrene	0-14	intercellular adhesion molecule 1	Homo sapiens	23-56
19327545-8	2009	Furthermore, LP cells from the small intestine in Bp-associated mice showed a tendency to produce slightly lower IFN-gamma and IL-6, while the cells from large intestine produced markedly higher IFN-gamma, IL-5 and IL-6 than those in the CONT group.	Benzo(a)pyrene	50-52	interferon gamma	Mus musculus	113-122
19327545-8	2009	Furthermore, LP cells from the small intestine in Bp-associated mice showed a tendency to produce slightly lower IFN-gamma and IL-6, while the cells from large intestine produced markedly higher IFN-gamma, IL-5 and IL-6 than those in the CONT group.	Benzo(a)pyrene	50-52	interleukin 6	Mus musculus	127-131
18948185-2	2008	Hence, co-exposure of cells to benzo[a]pyrene (BaP), a widespread environmental carcinogen and photosensitizing agent, and UVA may synergistically induce DNA damage.	Benzo(a)pyrene	31-45	prohibitin 2	Homo sapiens	47-50
18945501-0	2008	Enhancement of hypoxia-induced gene expression in fish liver by the aryl hydrocarbon receptor (AhR) ligand, benzo[a]pyrene (BaP).	Benzo(a)pyrene	108-122	aryl hydrocarbon receptor	Homo sapiens	68-93
18945501-0	2008	Enhancement of hypoxia-induced gene expression in fish liver by the aryl hydrocarbon receptor (AhR) ligand, benzo[a]pyrene (BaP).	Benzo(a)pyrene	108-122	aryl hydrocarbon receptor	Homo sapiens	95-98
18945501-0	2008	Enhancement of hypoxia-induced gene expression in fish liver by the aryl hydrocarbon receptor (AhR) ligand, benzo[a]pyrene (BaP).	Benzo(a)pyrene	124-127	aryl hydrocarbon receptor	Homo sapiens	68-93
18945501-0	2008	Enhancement of hypoxia-induced gene expression in fish liver by the aryl hydrocarbon receptor (AhR) ligand, benzo[a]pyrene (BaP).	Benzo(a)pyrene	124-127	aryl hydrocarbon receptor	Homo sapiens	95-98
18945501-5	2008	Here, the in vivo hepatic mRNA expression profiles of multiple hypoxia- and AhR-responsive genes (later gene expression=mRNA expression of the gene) were examined in the orange-spotted grouper (Epinephelus coioides) upon single and combined exposures to hypoxia and benzo[a]pyrene (BaP).	Benzo(a)pyrene	266-280	aryl hydrocarbon receptor	Homo sapiens	76-79
18945501-5	2008	Here, the in vivo hepatic mRNA expression profiles of multiple hypoxia- and AhR-responsive genes (later gene expression=mRNA expression of the gene) were examined in the orange-spotted grouper (Epinephelus coioides) upon single and combined exposures to hypoxia and benzo[a]pyrene (BaP).	Benzo(a)pyrene	282-285	aryl hydrocarbon receptor	Homo sapiens	76-79
18797853-4	2008	Our studies were carried out with metabolically competent primary porcine urinary bladder epithelial cells (PUBECs) and the human urothelial cell line 5637 for which we have previously demonstrated CYP1A1 mRNA induction by the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) applying real-time RT-PCR.	Benzo(a)pyrene	265-279	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	198-204
18793272-0	2008	Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.	Benzo(a)pyrene	22-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-73
18793272-3	2008	CYP1A1-inducible chemicals, such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin, are known to have adverse effects (i.e. carcinogenesis, mutagenesis and malformation).	Benzo(a)pyrene	36-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
19138996-8	2008	The reduction in B(a)P-induced DNA adducts was due, at least in part, to reduced metabolic activation of B(a)P. Collectively, these results suggest that 17-AAG and celastrol, inhibitors of HSP90, suppress the activation of AhR-dependent gene expression, leading, in turn, to reduced formation of B(a)P-induced DNA adducts.	Benzo(a)pyrene	17-22	heat shock protein 90 alpha family class A member 1	Homo sapiens	189-194
19138996-8	2008	The reduction in B(a)P-induced DNA adducts was due, at least in part, to reduced metabolic activation of B(a)P. Collectively, these results suggest that 17-AAG and celastrol, inhibitors of HSP90, suppress the activation of AhR-dependent gene expression, leading, in turn, to reduced formation of B(a)P-induced DNA adducts.	Benzo(a)pyrene	17-22	aryl hydrocarbon receptor	Homo sapiens	223-226
18788085-1	2008	Benzo[a]pyrene diol epoxide (B[a]PDE), the ultimate carcinogenic metabolite of benzo[a] pyrene, has been implicated in the mutagenesis of the p53 gene involved in smoking-associated lung cancer.	Benzo(a)pyrene	79-94	aldehyde dehydrogenase 7 family member A1	Homo sapiens	33-36
18788085-1	2008	Benzo[a]pyrene diol epoxide (B[a]PDE), the ultimate carcinogenic metabolite of benzo[a] pyrene, has been implicated in the mutagenesis of the p53 gene involved in smoking-associated lung cancer.	Benzo(a)pyrene	79-94	tumor protein p53	Homo sapiens	142-145
18573814-0	2008	Mutations induced by benzo[a]pyrene and dibenzo[a,l]pyrene in lacI transgenic B6C3F1 mouse lung result from stable DNA adducts.	Benzo(a)pyrene	21-35	tissue factor pathway inhibitor	Mus musculus	62-66
18790050-7	2008	Furthermore, GAPDH binding to the B-trisaccharide biotinyl polymer (BP)-probe [Galalpha1-3 (Fucalpha1-2) Gal-] was significantly higher as compared to B-disaccharide, Lewis D-trisaccharide, 3-fucosyl-N-acetylglucosamine and alpha-N-acetylneuraminic acid BP-probes.	Benzo(a)pyrene	68-70	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	13-18
18790050-7	2008	Furthermore, GAPDH binding to the B-trisaccharide biotinyl polymer (BP)-probe [Galalpha1-3 (Fucalpha1-2) Gal-] was significantly higher as compared to B-disaccharide, Lewis D-trisaccharide, 3-fucosyl-N-acetylglucosamine and alpha-N-acetylneuraminic acid BP-probes.	Benzo(a)pyrene	254-256	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	13-18
18656550-7	2008	We have investigated the effect of the lung carcinogens cigarette-smoke condensate (CSC) and benzo[a]pyrene (B[a]P) on the promoters of the IL1B gene varying only at the site of the -31T/C polymorphism.	Benzo(a)pyrene	93-107	interleukin 1 beta	Homo sapiens	140-144
18671994-0	2008	Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	80-105
19080118-11	2008	CONCLUSIONS: This study provides the global transcription profiling associated with the tumorigenesis of oral epithelial cells exposed to benzo (a) pyrene; IGFBP3 may play a potential role in the initiation of oral cancer related to benzo (a) pyrene exposure.	Benzo(a)pyrene	138-154	insulin like growth factor binding protein 3	Homo sapiens	156-162
19080118-11	2008	CONCLUSIONS: This study provides the global transcription profiling associated with the tumorigenesis of oral epithelial cells exposed to benzo (a) pyrene; IGFBP3 may play a potential role in the initiation of oral cancer related to benzo (a) pyrene exposure.	Benzo(a)pyrene	233-249	insulin like growth factor binding protein 3	Homo sapiens	156-162
18664595-6	2008	In 3T3-L1 cells, treatment with AhR agonists including benzo[a]pyrene and 3-methylcholanthrene reproduced the antiadipogenic effect of C. militaris.	Benzo(a)pyrene	55-69	aryl-hydrocarbon receptor	Mus musculus	32-35
18759501-10	2008	Mass spectrometric analysis of NAT1 from HeLa cells in which NAT1 was overexpressed showed that treatment of the cells with 4-NO-BP resulted in sulfinamide adduct formation.	Benzo(a)pyrene	129-131	N-acetyltransferase 1	Homo sapiens	31-35
18759501-10	2008	Mass spectrometric analysis of NAT1 from HeLa cells in which NAT1 was overexpressed showed that treatment of the cells with 4-NO-BP resulted in sulfinamide adduct formation.	Benzo(a)pyrene	129-131	N-acetyltransferase 1	Homo sapiens	61-65
18941584-6	2008	Prenatal PAH exposure was measured by PAH-DNA adducts (benzo[a]pyrene-DNA) in umbilical cord blood.	Benzo(a)pyrene	55-69	phenylalanine hydroxylase	Homo sapiens	9-12
18941584-6	2008	Prenatal PAH exposure was measured by PAH-DNA adducts (benzo[a]pyrene-DNA) in umbilical cord blood.	Benzo(a)pyrene	55-69	phenylalanine hydroxylase	Homo sapiens	38-41
18939564-3	2008	Emission factors for benzo[a]pyrene (BaP) for a tunnel fleet operating under cruise conditions were highest prior to the 1980s and fell from more than 30-microg per vehicle-km to approximately 2-microg/km in the 1990s, an approximately 15-fold decline.	Benzo(a)pyrene	21-35	prohibitin 2	Homo sapiens	37-40
22063352-4	2008	The maximum level for benzo[a]pyrene (BaP) of 5mug/kg in smoked meat products was not exceeded in any samples.	Benzo(a)pyrene	22-36	prohibitin 2	Homo sapiens	38-41
18675828-6	2008	Overall, UGT1A1-53 and -3156 genotypes modified the association between dietary benzo(a)pyrene (BaP) and colon cancer (P for interaction=0.02 and 0.03, respectively).	Benzo(a)pyrene	96-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	9-15
18675828-7	2008	The strongest association was observed for those with &lt;7.7 ng/day BaP exposure and the low activity genotypes, for both UGT1A1 28/28 (OR=1.8, 95% CI=1.1-2.9) and -3156AA (OR=1.7, 95% CI=1.0-3.0), compared to &gt;or=7.7 ng/day and combined high/intermediate genotypes.	Benzo(a)pyrene	69-72	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	123-129
18694800-0	2008	The effect of initiating doses of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene on the expression of PAH activating enzymes and its modulation by plant phenols.	Benzo(a)pyrene	34-48	phenylalanine hydroxylase	Mus musculus	105-108
18694800-3	2008	The aim of the present study was further examination of the effect of these compounds on the expression and activities of CYP1A1/1A2, CYP1B1, CYP2B, and phase 2 enzymes in female BALB/C mouse epidermis treated with an initiating dose of B[a]P or DMBA.	Benzo(a)pyrene	237-242	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	122-128
18794127-11	2008	Benzo(a)pyrene (BP), which is similarly activated by Cyp1b1 in vitro, did not affect tumorigenesis in Min mice.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	53-59
18794127-11	2008	Benzo(a)pyrene (BP), which is similarly activated by Cyp1b1 in vitro, did not affect tumorigenesis in Min mice.	Benzo(a)pyrene	16-18	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	53-59
18165973-7	2008	Moreover, a refined phenotype restricted to BP associated with psychosis yielded significant evidence for linkage in each individual sample (NPL(all) = 2.38 in sample 1; NPL(all) = 2.72) while yielding the best result (NPL(all) score = 3.90) in the combined sample (samples 1 and 2), despite an important reduction in the number of affected individuals.	Benzo(a)pyrene	44-46	N-acetylneuraminate pyruvate lyase	Homo sapiens	141-144
18165973-7	2008	Moreover, a refined phenotype restricted to BP associated with psychosis yielded significant evidence for linkage in each individual sample (NPL(all) = 2.38 in sample 1; NPL(all) = 2.72) while yielding the best result (NPL(all) score = 3.90) in the combined sample (samples 1 and 2), despite an important reduction in the number of affected individuals.	Benzo(a)pyrene	44-46	N-acetylneuraminate pyruvate lyase	Homo sapiens	170-173
18165973-7	2008	Moreover, a refined phenotype restricted to BP associated with psychosis yielded significant evidence for linkage in each individual sample (NPL(all) = 2.38 in sample 1; NPL(all) = 2.72) while yielding the best result (NPL(all) score = 3.90) in the combined sample (samples 1 and 2), despite an important reduction in the number of affected individuals.	Benzo(a)pyrene	44-46	N-acetylneuraminate pyruvate lyase	Homo sapiens	170-173
21791370-1	2008	The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P).	Benzo(a)pyrene	168-182	prohibitin 2	Homo sapiens	184-189
18555675-7	2008	BP nanoparticles were targeted in vitro to brain tumor (glioma) cells (BT4C) by three-step avidin-biotin technology using transferrin as the targeting ligand.	Benzo(a)pyrene	0-2	transferrin	Homo sapiens	122-133
21218107-1	2008	Two compounds known to covalently bind to DNA after their activation with cytochromes P450 (CYPs), carcinogenic benzo(a)pyrene (BaP) and an antineoplastic agent ellipticine, were investigated for their potential to induce CYP and NADPH:CYP reductase (POR) enzymes in rodent livers, the main target organ for DNA adduct formation.	Benzo(a)pyrene	112-126	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	92-95
18508962-2	2008	In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP.	Benzo(a)pyrene	85-87	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	28-55
18834169-6	2008	On the other hand, the activity of phospholipase A2 toward DLPC used as a probe to locate benzo[a]pyrene in the monolayers indicates that the polyaromatic hydrocarbons are not accessible to the enzyme.	Benzo(a)pyrene	90-104	phospholipase A2 group IB	Homo sapiens	35-51
18761371-13	2008	The results suggest that in utero exposure to benzo(a)pyrene results in diminished mRNA expression of the NMDA NR2B receptor subunit to result in late life deficits in cortical neuronal activity in the offspring.	Benzo(a)pyrene	46-60	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	111-115
18466204-1	2008	Solar UV radiation and benzo[a]pyrene (BaP) are two carcinogenic agents.	Benzo(a)pyrene	23-37	prohibitin 2	Homo sapiens	39-42
18318570-7	2008	Analysis of response surface models for the ternary mixtures indicated antagonistic interactions between BaP and PCB 77 and a possible inhibitory effect of cadmium on PCB 77- induced CYP1A.	Benzo(a)pyrene	105-108	pyruvate carboxylase	Rattus norvegicus	113-116
18508962-2	2008	In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP.	Benzo(a)pyrene	85-87	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	57-61
18508962-2	2008	In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP.	Benzo(a)pyrene	85-87	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	138-142
18508962-2	2008	In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP.	Benzo(a)pyrene	181-183	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	28-55
18508962-2	2008	In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP.	Benzo(a)pyrene	181-183	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	57-61
18508962-2	2008	In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than wild-type mice, raising the possibility that Oat3 transports an endogenous regulator of BP.	Benzo(a)pyrene	181-183	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	138-142
18508962-5	2008	In vivo, thymidine, as well as two of the most potent Oat3 inhibitors that were characterized, reduced BP by 10 to 15%; therefore, Oat3 seems to regulate BP, and Oat3 inhibitors might be therapeutically useful antihypertensive agents.	Benzo(a)pyrene	103-105	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	54-58
18508962-5	2008	In vivo, thymidine, as well as two of the most potent Oat3 inhibitors that were characterized, reduced BP by 10 to 15%; therefore, Oat3 seems to regulate BP, and Oat3 inhibitors might be therapeutically useful antihypertensive agents.	Benzo(a)pyrene	103-105	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	131-135
18508962-5	2008	In vivo, thymidine, as well as two of the most potent Oat3 inhibitors that were characterized, reduced BP by 10 to 15%; therefore, Oat3 seems to regulate BP, and Oat3 inhibitors might be therapeutically useful antihypertensive agents.	Benzo(a)pyrene	103-105	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	131-135
18430445-10	2008	Moreover, B[a]P-induced cytotoxicity and mutagenicity were significantly increased in cells depleted of endogenous Rad51.	Benzo(a)pyrene	10-15	RAD51 recombinase	Homo sapiens	115-120
18571745-6	2008	The CYP19A1 expression was significantly decreased after BaP exposure in the 3-month-old Fundulus immature oocytes, but BaP did not affect CYP19A1 expression at any stage in adult oocytes.	Benzo(a)pyrene	57-60	aromatase	Fundulus heteroclitus	4-11
18571745-9	2008	Promoter regions of Fundulus CYP19s were cloned, and putative response elements in the CYP19A1 and CYP19A2 promoters such as CRE, AhR and ERE may be involved in BaP-mediated changes in CYP19 expression.	Benzo(a)pyrene	161-164	aromatase	Fundulus heteroclitus	87-94
18077013-6	2008	The BNP measured at peak exercise was also associated with the BP response (p=0.003).	Benzo(a)pyrene	63-65	natriuretic peptide B	Homo sapiens	4-7
18372000-0	2008	Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.	Benzo(a)pyrene	133-147	aryl hydrocarbon receptor	Homo sapiens	14-39
18372000-0	2008	Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.	Benzo(a)pyrene	133-147	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	84-88
18372000-2	2008	BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	18-43
18372000-2	2008	BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	45-48
18372000-2	2008	BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	110-116
18372000-2	2008	BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds.	Benzo(a)pyrene	135-138	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	110-116
18372000-4	2008	In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	42-46
18372000-4	2008	In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
18372000-4	2008	In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	64-70
18372000-4	2008	In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-81
18372000-4	2008	In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells.	Benzo(a)pyrene	86-89	aryl hydrocarbon receptor	Homo sapiens	98-101
18372000-5	2008	Transfection of CYP1A1 and CYP1B1, but not CYP1A2, suppressed BaP-induced activation of AhR.	Benzo(a)pyrene	62-65	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
18372000-5	2008	Transfection of CYP1A1 and CYP1B1, but not CYP1A2, suppressed BaP-induced activation of AhR.	Benzo(a)pyrene	62-65	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33
18372000-5	2008	Transfection of CYP1A1 and CYP1B1, but not CYP1A2, suppressed BaP-induced activation of AhR.	Benzo(a)pyrene	62-65	aryl hydrocarbon receptor	Homo sapiens	88-91
18372000-6	2008	Expression of CYP1A1 and CYP1A2, but not CYP1B1, inhibited DNA adduct formation in BaP-treated HepG2 cells.	Benzo(a)pyrene	83-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
18372000-6	2008	Expression of CYP1A1 and CYP1A2, but not CYP1B1, inhibited DNA adduct formation in BaP-treated HepG2 cells.	Benzo(a)pyrene	83-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31
18372000-7	2008	These results indicate that CYP1A1 and CYP1B1 play a role in deactivation of BaP on AhR and that CYP1A1 and CYP1A2 are involved in BaP detoxification by suppressing DNA adduct formation.	Benzo(a)pyrene	77-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34
18372000-7	2008	These results indicate that CYP1A1 and CYP1B1 play a role in deactivation of BaP on AhR and that CYP1A1 and CYP1A2 are involved in BaP detoxification by suppressing DNA adduct formation.	Benzo(a)pyrene	77-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45
18372000-7	2008	These results indicate that CYP1A1 and CYP1B1 play a role in deactivation of BaP on AhR and that CYP1A1 and CYP1A2 are involved in BaP detoxification by suppressing DNA adduct formation.	Benzo(a)pyrene	77-80	aryl hydrocarbon receptor	Homo sapiens	84-87
18372000-10	2008	Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP.	Benzo(a)pyrene	194-197	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	22-28
18372000-10	2008	Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP.	Benzo(a)pyrene	194-197	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	30-36
18372000-10	2008	Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP.	Benzo(a)pyrene	194-197	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	41-47
18381355-0	2008	Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage.	Benzo(a)pyrene	46-49	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-19
18381355-4	2008	Therefore, PXR could modulate the genotoxicity of BaP by changing the balance of the metabolic pathways in favor of BaP detoxification.	Benzo(a)pyrene	50-53	nuclear receptor subfamily 1 group I member 2	Homo sapiens	11-14
18381355-4	2008	Therefore, PXR could modulate the genotoxicity of BaP by changing the balance of the metabolic pathways in favor of BaP detoxification.	Benzo(a)pyrene	116-119	nuclear receptor subfamily 1 group I member 2	Homo sapiens	11-14
18381355-6	2008	The presence of transfected PXR significantly reduced the level of adducts relative to parental cells by 50-65% (p &lt; 0.001), demonstrating that PXR protects liver cells from genotoxicity induced by exposure to BaP.	Benzo(a)pyrene	213-216	nuclear receptor subfamily 1 group I member 2	Homo sapiens	28-31
18381355-6	2008	The presence of transfected PXR significantly reduced the level of adducts relative to parental cells by 50-65% (p &lt; 0.001), demonstrating that PXR protects liver cells from genotoxicity induced by exposure to BaP.	Benzo(a)pyrene	213-216	nuclear receptor subfamily 1 group I member 2	Homo sapiens	147-150
18381355-8	2008	The messenger RNA levels of CYP1A2, GSTA1, GSTA2, GSTM1, UGT1A6, and BCRP (ABCG2) were significantly higher in cells overexpressing PXR, independent of exposure to BaP.	Benzo(a)pyrene	164-167	nuclear receptor subfamily 1 group I member 2	Homo sapiens	132-135
18381355-9	2008	In addition, the total GST enzymatic activity, which favors the metabolic detoxification of BaP, was significantly increased by the presence of PXR (p &lt; 0.001), independent of BaP exposure.	Benzo(a)pyrene	92-95	nuclear receptor subfamily 1 group I member 2	Homo sapiens	144-147
18381355-10	2008	Taken together, these results suggest that PXR plays an important role in protection against DNA damage by polycyclic aromatic hydrocarbons (PAHs) such as BaP, and that these protective effects may be through a coordinated regulation of genes involved in xenobiotic metabolism.	Benzo(a)pyrene	155-158	nuclear receptor subfamily 1 group I member 2	Homo sapiens	43-46
18839518-0	2008	[Cell cycle alterations of human embryo lung fibroblasts induced by benzo(a)pyrene is positively regulated by cyclin D1 and CDK4].	Benzo(a)pyrene	68-82	cyclin D1	Homo sapiens	110-119
18839518-0	2008	[Cell cycle alterations of human embryo lung fibroblasts induced by benzo(a)pyrene is positively regulated by cyclin D1 and CDK4].	Benzo(a)pyrene	68-82	cyclin dependent kinase 4	Homo sapiens	124-128
18839518-1	2008	OBJECTIVE: To study the effects of benzo(a)pyrene (B(a)P) on the cell cycle distributions and expression of cell cycle regulated protein cyclin D1 and CDK4 in human embryo lung fibroblasts (HELF), and to investigate the relationship between the expression of both cyclin D1 and CDK4 proteins and the cell cycle alterations.	Benzo(a)pyrene	35-49	cyclin D1	Homo sapiens	137-146
18499698-10	2008	The OR (95% CI) of PC was 2.23 (1.33-3.72) and 2.54 (1.51-4.25) for men having the NAT1*10 and a higher intake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene, respectively, compared with individuals having no NAT1*10 or a lower intake of these dietary mutagens.	Benzo(a)pyrene	166-180	N-acetyltransferase 1	Homo sapiens	83-87
18470301-5	2008	PAH-DNA adducts (specifically benzo[a]pyrene adducts) provided a biologically relevant measure of PAH exposure.	Benzo(a)pyrene	30-44	phenylalanine hydroxylase	Homo sapiens	0-3
18578667-7	2008	CONCLUSION: In small vessels, a supraphysiologic hematocrit increased the BP of both arteries and veins when using the Harmonic ACE or the LigaSure V. With the devices tested, anemia did not seem to affect BP.	Benzo(a)pyrene	74-76	angiotensin-converting enzyme	Sus scrofa	128-131
18498718-2	2008	BP (50 mgkg(-1)) induced deleterious changes that were that revealed by alterations in lipid peroxidation, membrane-bound enzyme (Na+/K+ ATPase, Ca2+ ATPase and Mg2+ ATPase) activity, levels of total protein and protein-bound carbohydrate components (sialic acid, hexose, hexosamine, hexuronic acid and fucose).	Benzo(a)pyrene	0-2	carbonic anhydrase 2	Mus musculus	145-156
18498718-2	2008	BP (50 mgkg(-1)) induced deleterious changes that were that revealed by alterations in lipid peroxidation, membrane-bound enzyme (Na+/K+ ATPase, Ca2+ ATPase and Mg2+ ATPase) activity, levels of total protein and protein-bound carbohydrate components (sialic acid, hexose, hexosamine, hexuronic acid and fucose).	Benzo(a)pyrene	0-2	dynein, axonemal, heavy chain 8	Mus musculus	161-172
18372398-3	2008	Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1.	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-57
18372398-3	2008	Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1.	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	135-141
18372398-3	2008	Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1.	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	205-211
18372398-3	2008	Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1.	Benzo(a)pyrene	21-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-57
18372398-3	2008	Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1.	Benzo(a)pyrene	21-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	135-141
18372398-3	2008	Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1.	Benzo(a)pyrene	21-24	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	205-211
18372398-4	2008	Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "rescued" response as that seen in the Cyp1a1/1b1(-/-) mouse; we believe this reflects the absence of CYP1B1 in immune tissues.	Benzo(a)pyrene	5-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	17-23
18372398-4	2008	Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "rescued" response as that seen in the Cyp1a1/1b1(-/-) mouse; we believe this reflects the absence of CYP1B1 in immune tissues.	Benzo(a)pyrene	5-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	97-103
18372398-4	2008	Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "rescued" response as that seen in the Cyp1a1/1b1(-/-) mouse; we believe this reflects the absence of CYP1B1 in immune tissues.	Benzo(a)pyrene	5-8	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	160-166
19035040-1	2008	OBJECTIVE: To investigate the roles of p53 in cell cycle changes on human embryo lung fibroblasts (HELF) induced by benzo(a) pyrene[ B(a) P], and relationships between p53 and p21, E2F-1.	Benzo(a)pyrene	116-131	tumor protein p53	Homo sapiens	39-42
18440733-0	2008	Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	44-47
18440733-0	2008	Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	77-80
18440733-5	2008	However, procaspase-7 cleavage in MCF-7 cells by BP-treatment indicates activation of caspase-7 meaning that apoptosis is most likely involved in BP-induced MCF-7 cell death.	Benzo(a)pyrene	49-51	caspase 7	Homo sapiens	12-21
18440733-10	2008	These results suggest that serine 392 phosphorylation is the first stabilizing event of p53 associated with BP exposure and subsequent cell death in MCF-7 cells.	Benzo(a)pyrene	108-110	tumor protein p53	Homo sapiens	88-91
18448277-0	2008	Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts.	Benzo(a)pyrene	0-14	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
18448277-0	2008	Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	89-92
18448277-0	2008	Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts.	Benzo(a)pyrene	0-14	AKT serine/threonine kinase 1	Homo sapiens	109-112
18448277-0	2008	Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	113-116
18406507-0	2008	MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation.	Benzo(a)pyrene	50-64	mitogen-activated protein kinase 1	Homo sapiens	0-4
18406507-0	2008	MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation.	Benzo(a)pyrene	50-64	tumor protein p53	Homo sapiens	14-17
18406507-0	2008	MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation.	Benzo(a)pyrene	50-64	tumor protein p53	Homo sapiens	81-84
18406507-1	2008	Benzo[a]pyrene (BaP) is a potentially genotoxic and cytotoxic environmental pollutant.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
18406507-3	2008	Cell death induced by benzo[a]pyrene in the HepG(2) cells is dependent on PARP-1 activation and NAD depletion.	Benzo(a)pyrene	22-36	poly(ADP-ribose) polymerase 1	Homo sapiens	74-80
18396263-0	2008	Benzo[a]pyrene inhibits osteoclastogenesis by affecting RANKL-induced activation of NF-kappaB.	Benzo(a)pyrene	0-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	56-61
18396263-0	2008	Benzo[a]pyrene inhibits osteoclastogenesis by affecting RANKL-induced activation of NF-kappaB.	Benzo(a)pyrene	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93
18396263-2	2008	We previously demonstrated that exposure to benzo[a]pyrene (BaP), an environmental pollutant present in high concentrations in urban smog and cigarette smoke, inhibits osteoclast differentiation and bone resorption.	Benzo(a)pyrene	44-58	prohibitin 2	Mus musculus	60-63
18470301-5	2008	PAH-DNA adducts (specifically benzo[a]pyrene adducts) provided a biologically relevant measure of PAH exposure.	Benzo(a)pyrene	30-44	phenylalanine hydroxylase	Homo sapiens	98-101
18377894-0	2008	The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.	Benzo(a)pyrene	157-171	RAD51 recombinase	Homo sapiens	27-32
18377894-4	2008	We hypothesized that gefitinib enhances B[a]P-mediated cytotoxicity by decreasing ERK1/2 activation.	Benzo(a)pyrene	40-45	mitogen-activated protein kinase 3	Homo sapiens	82-88
17879257-6	2008	These studies confirmed increased mRNA levels in NHEK by BaP of alpha-integrin binding protein 63 (AIBP63) (2.48-fold), retinoic acid- and interferon-inducible protein (IFIT5) (2.74-fold), interleukin-1 alpha (IL1A) (2.64-fold), interleukin-1 beta (IL1B) (2.84-fold) and Ras guanyl releasing protein 1 (RASGRP1) (3.14-fold).	Benzo(a)pyrene	57-60	HPS5 biogenesis of lysosomal organelles complex 2 subunit 2	Homo sapiens	64-97
17879257-6	2008	These studies confirmed increased mRNA levels in NHEK by BaP of alpha-integrin binding protein 63 (AIBP63) (2.48-fold), retinoic acid- and interferon-inducible protein (IFIT5) (2.74-fold), interleukin-1 alpha (IL1A) (2.64-fold), interleukin-1 beta (IL1B) (2.84-fold) and Ras guanyl releasing protein 1 (RASGRP1) (3.14-fold).	Benzo(a)pyrene	57-60	HPS5 biogenesis of lysosomal organelles complex 2 subunit 2	Homo sapiens	99-105
18492619-12	2008	The addition of BaP enhanced arecolineinduced HO-1 expression (p &lt; 0.05).	Benzo(a)pyrene	16-19	heme oxygenase 1	Homo sapiens	46-50
18096572-4	2008	In contrast, activation of the AHR with 3-methylcholanthrene or benzo[a]pyrene resulted in predominant formation of AHR*ARNT complexes.	Benzo(a)pyrene	64-78	aryl-hydrocarbon receptor	Mus musculus	31-34
18096572-4	2008	In contrast, activation of the AHR with 3-methylcholanthrene or benzo[a]pyrene resulted in predominant formation of AHR*ARNT complexes.	Benzo(a)pyrene	64-78	aryl-hydrocarbon receptor	Mus musculus	116-119
18096572-4	2008	In contrast, activation of the AHR with 3-methylcholanthrene or benzo[a]pyrene resulted in predominant formation of AHR*ARNT complexes.	Benzo(a)pyrene	64-78	aryl hydrocarbon receptor nuclear translocator	Mus musculus	120-124
18646516-0	2008	[Overexpression and higher phosphorylation of p53 induced by benzo(a) pyrene through activated protein 1 independent pathway].	Benzo(a)pyrene	61-76	tumor protein p53	Homo sapiens	46-49
18646516-1	2008	OBJECTIVE: To investigate changes of p53 expression, p53 phosphorylation, and their subcellular localizations and activated protein 1 (AP-1) activity on human embryo lung fibroblasts (HELF) induced by benzo(a)pyrene (B(a)P), and relationships between p53 and AP-1.	Benzo(a)pyrene	201-215	tumor protein p53	Homo sapiens	37-40
18646516-1	2008	OBJECTIVE: To investigate changes of p53 expression, p53 phosphorylation, and their subcellular localizations and activated protein 1 (AP-1) activity on human embryo lung fibroblasts (HELF) induced by benzo(a)pyrene (B(a)P), and relationships between p53 and AP-1.	Benzo(a)pyrene	201-215	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-139
18646516-1	2008	OBJECTIVE: To investigate changes of p53 expression, p53 phosphorylation, and their subcellular localizations and activated protein 1 (AP-1) activity on human embryo lung fibroblasts (HELF) induced by benzo(a)pyrene (B(a)P), and relationships between p53 and AP-1.	Benzo(a)pyrene	201-215	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	259-263
17998932-6	2008	In cell lines ensuing from benzo(a)pyrene-treated cultures the combined p53 mutation pattern from experiments with the 3 codon 72 genotypes showed a predominance of strand-biased G to T transversions (18 of 36 mutations), and mutations recurring at smokers" lung tumour hotspot codons 157 and 273, supporting involvement of tobacco carcinogens in shaping the mutation signature in lung cancers of smokers.	Benzo(a)pyrene	27-41	tumor protein p53	Homo sapiens	72-75
18395061-7	2008	The feasibility of determining benzo[a]pyrene in real samples was successfully evaluated through the analysis of spiked tap, underground and mineral water samples of different origins.	Benzo(a)pyrene	31-45	nuclear RNA export factor 1	Homo sapiens	120-123
18321631-0	2008	The effects of over-expression and suppression of Cdc25A on the S-phase checkpoint induced by benzo(a)pyrene.	Benzo(a)pyrene	94-108	cell division cycle 25A	Homo sapiens	50-56
18321631-1	2008	Our previous results have indicated that Cdc25A is involved in benzo(a)pyrene (BaP)-induced S-phase checkpoint in 16HBE cells and A549 cells.	Benzo(a)pyrene	63-77	cell division cycle 25A	Homo sapiens	41-47
18321631-1	2008	Our previous results have indicated that Cdc25A is involved in benzo(a)pyrene (BaP)-induced S-phase checkpoint in 16HBE cells and A549 cells.	Benzo(a)pyrene	79-82	cell division cycle 25A	Homo sapiens	41-47
18321631-2	2008	In this paper, we reported the changes of the downstream molecular pathway of Cdc25A and the effects of over-expression and suppression of Cdc25A on BaP-induced S-phase checkpoint.	Benzo(a)pyrene	149-152	cell division cycle 25A	Homo sapiens	78-84
18321631-2	2008	In this paper, we reported the changes of the downstream molecular pathway of Cdc25A and the effects of over-expression and suppression of Cdc25A on BaP-induced S-phase checkpoint.	Benzo(a)pyrene	149-152	cell division cycle 25A	Homo sapiens	139-145
18321631-3	2008	In the S-phase checkpoint induced by BaP the reduction of Cdc25A contributes to cyclin A inhibition.	Benzo(a)pyrene	37-40	cell division cycle 25A	Homo sapiens	58-64
18321631-3	2008	In the S-phase checkpoint induced by BaP the reduction of Cdc25A contributes to cyclin A inhibition.	Benzo(a)pyrene	37-40	cyclin A2	Homo sapiens	80-88
18321631-4	2008	Over-expression of Cdc25A abrogated BaP-induced S-phase arrest in 16HBE cells and concomitantly the expression levels of Cdk2 and cyclin A were not obviously changed by BaP when compared with the control.	Benzo(a)pyrene	36-39	cell division cycle 25A	Homo sapiens	19-25
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	90-93	cell division cycle 25A	Homo sapiens	0-6
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	90-93	cell division cycle 25A	Homo sapiens	213-219
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	90-93	checkpoint kinase 1	Homo sapiens	239-243
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	90-93	cell division cycle 25A	Homo sapiens	213-219
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	90-93	cyclin A2	Homo sapiens	251-259
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	90-93	cyclin dependent kinase 2	Homo sapiens	260-264
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	cell division cycle 25A	Homo sapiens	0-6
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	cyclin A2	Homo sapiens	141-149
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	cell division cycle 25A	Homo sapiens	213-219
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	checkpoint kinase 1	Homo sapiens	239-243
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	cell division cycle 25A	Homo sapiens	213-219
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	cyclin A2	Homo sapiens	251-259
18321631-5	2008	Cdc25A down-regulation by RNA interference (RNAi) prolonged the S-phase arrest induced by BaP and decreased clearly the expression levels of cyclin A and cyclin E. Therefore, our results further demonstrated that Cdc25A was an effector in Chk1-Cdc25A-cyclin A/Cdk2 pathway of S-phase checkpoint elicited by the carcinogen BaP in 16HBE cells.	Benzo(a)pyrene	322-325	cyclin dependent kinase 2	Homo sapiens	260-264
18255115-0	2008	A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells.	Benzo(a)pyrene	76-90	lactotransferrin	Rattus norvegicus	6-17
18336843-0	2008	Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.	Benzo(a)pyrene	61-75	tumor necrosis factor	Rattus norvegicus	0-27
18336843-0	2008	Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.	Benzo(a)pyrene	61-75	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	130-149
18336843-2	2008	The ultimate carcinogenic BaP metabolite produced by cytochrome P450 enzymes (CYP), such as CYP1A1 and CYP1B1, anti-BaP-7,8-diol-9,10-epoxide, binds covalently to DNA and causes mutations.	Benzo(a)pyrene	26-29	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	92-98
18336843-2	2008	The ultimate carcinogenic BaP metabolite produced by cytochrome P450 enzymes (CYP), such as CYP1A1 and CYP1B1, anti-BaP-7,8-diol-9,10-epoxide, binds covalently to DNA and causes mutations.	Benzo(a)pyrene	26-29	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	103-109
18336843-5	2008	TNF-alpha enhanced induction of CYP1B1, while it simultaneously suppressed the BaP-induced CYP1A1 expression.	Benzo(a)pyrene	79-82	tumor necrosis factor	Rattus norvegicus	0-9
18336843-5	2008	TNF-alpha enhanced induction of CYP1B1, while it simultaneously suppressed the BaP-induced CYP1A1 expression.	Benzo(a)pyrene	79-82	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	91-97
18336843-8	2008	Inhibition of CYP1B1 by fluoranthene significantly decreased both the formation of DNA adducts and the induction of apoptosis in WB-F344 cells treated with BaP and TNF-alpha, thus suggesting that this isoform might be responsible for genotoxic effects of BaP in nonparenchymal liver cells.	Benzo(a)pyrene	156-159	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	14-20
18336843-8	2008	Inhibition of CYP1B1 by fluoranthene significantly decreased both the formation of DNA adducts and the induction of apoptosis in WB-F344 cells treated with BaP and TNF-alpha, thus suggesting that this isoform might be responsible for genotoxic effects of BaP in nonparenchymal liver cells.	Benzo(a)pyrene	255-258	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	14-20
18336843-8	2008	Inhibition of CYP1B1 by fluoranthene significantly decreased both the formation of DNA adducts and the induction of apoptosis in WB-F344 cells treated with BaP and TNF-alpha, thus suggesting that this isoform might be responsible for genotoxic effects of BaP in nonparenchymal liver cells.	Benzo(a)pyrene	255-258	tumor necrosis factor	Rattus norvegicus	164-173
18336845-8	2008	Only CYP1B1 and ALDH1A3 were consistently up-regulated by approximately 3-fold in most of the cell strains (at least 4) when exposed to BP.	Benzo(a)pyrene	136-138	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	5-11
18336845-8	2008	Only CYP1B1 and ALDH1A3 were consistently up-regulated by approximately 3-fold in most of the cell strains (at least 4) when exposed to BP.	Benzo(a)pyrene	136-138	aldehyde dehydrogenase 1 family member A3	Homo sapiens	16-23
18425702-2	2008	However, target BP levels based on HBP remain unknown.	Benzo(a)pyrene	16-18	heme binding protein 1	Homo sapiens	35-38
19295093-12	2008	Carcinogenic potencies for DbA and BaP in PAH mixtures based on TEF concept were 45% and 39% respectively.	Benzo(a)pyrene	35-38	TEF transcription factor, PAR bZIP family member	Homo sapiens	64-67
17932951-0	2008	Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.	Benzo(a)pyrene	21-35	MDM2 proto-oncogene	Homo sapiens	54-58
17932951-0	2008	Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.	Benzo(a)pyrene	21-35	tumor protein p53	Homo sapiens	63-66
18204078-1	2008	Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are metabolically activated by cytochrome P450s (CYPs).	Benzo(a)pyrene	129-143	prohibitin 2	Homo sapiens	145-148
17449565-6	2008	RESULTS: Benzo[a]pyrene (BaP) was detected at all workplaces.	Benzo(a)pyrene	9-23	prohibitin 2	Homo sapiens	25-28
18390591-6	2008	Removal of KNAT6 activity suppressed the pny phenotype and partially rescued the bp phenotype.	Benzo(a)pyrene	81-83	homeobox protein knotted-1-like 6	Arabidopsis thaliana	11-16
18096571-0	2008	Mdm2 as a sensitive and mechanistically informative marker for genotoxicity induced by benzo[a]pyrene and dibenzo[a,l]pyrene.	Benzo(a)pyrene	87-101	MDM2 proto-oncogene	Homo sapiens	0-4
18096571-3	2008	Employing the Mdm2 2A10 antibody and phosphatase treatment we found that Mdm2 accumulated in HepG2 cells when exposed to low concentrations of genotoxic compounds such as mitomycin C, etoposide, 5-fluorouracil, and benzo[a]pyrene (BP).	Benzo(a)pyrene	215-229	MDM2 proto-oncogene	Homo sapiens	73-77
18096571-3	2008	Employing the Mdm2 2A10 antibody and phosphatase treatment we found that Mdm2 accumulated in HepG2 cells when exposed to low concentrations of genotoxic compounds such as mitomycin C, etoposide, 5-fluorouracil, and benzo[a]pyrene (BP).	Benzo(a)pyrene	231-233	MDM2 proto-oncogene	Homo sapiens	73-77
18096571-4	2008	The low-dose responses were not accompanied by p53 accumulation and the effect of low concentrations of BP on Mdm2 was not affected by small interfering RNA for p53.	Benzo(a)pyrene	104-106	MDM2 proto-oncogene	Homo sapiens	110-114
18096571-5	2008	In human lymphoblasts 10nM BP induced an Mdm2 response.	Benzo(a)pyrene	27-29	MDM2 proto-oncogene	Homo sapiens	41-45
18096571-6	2008	Low concentrations of BP also induced binding of Mdm2 to chromatin in HepG2 cells, but no p53 binding or H2AX phosphorylation.	Benzo(a)pyrene	22-24	MDM2 proto-oncogene	Homo sapiens	49-53
18096571-7	2008	The more mutagenic dibenzo[a,l]pyrene as well as higher BP concentrations instead induced gammaH2AX and p53 Ser15 association with chromatin.	Benzo(a)pyrene	56-58	tumor protein p53	Homo sapiens	104-107
18096571-8	2008	Acrolein potentiated the effect of BP on p53 stabilization and chromatin binding.	Benzo(a)pyrene	35-37	tumor protein p53	Homo sapiens	41-44
18289803-0	2008	Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.	Benzo(a)pyrene	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
18289803-0	2008	Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.	Benzo(a)pyrene	57-71	aryl hydrocarbon receptor	Homo sapiens	75-100
18289803-3	2008	In primary human macrophages, BP was shown to induce IL-8 expression at both mRNA and secretion levels in a dose-dependent manner.	Benzo(a)pyrene	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
18289803-4	2008	Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference.	Benzo(a)pyrene	92-94	aryl hydrocarbon receptor	Homo sapiens	43-68
18289803-4	2008	Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference.	Benzo(a)pyrene	92-94	aryl hydrocarbon receptor	Homo sapiens	70-73
18289803-4	2008	Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference.	Benzo(a)pyrene	92-94	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
18289803-4	2008	Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference.	Benzo(a)pyrene	92-94	aryl hydrocarbon receptor	Homo sapiens	137-140
18289803-5	2008	Moreover, electrophoretic mobility shift assays (EMSAs) and chromatin immunoprecipitation experiments showed BP-triggered binding of AhR to a consensus xenobiotic responsive element (XRE) found in the human IL-8 promoter.	Benzo(a)pyrene	109-111	aryl hydrocarbon receptor	Homo sapiens	133-136
18289803-5	2008	Moreover, electrophoretic mobility shift assays (EMSAs) and chromatin immunoprecipitation experiments showed BP-triggered binding of AhR to a consensus xenobiotic responsive element (XRE) found in the human IL-8 promoter.	Benzo(a)pyrene	109-111	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
18289803-6	2008	Finally, BP administration to mice led to over-expression of keratinocyte chemoattractant (KC), the murine functional homologue of IL-8, in lung.	Benzo(a)pyrene	9-11	chemokine (C-X-C motif) ligand 15	Mus musculus	131-135
18289803-7	2008	It also triggered the recruitment of neutrophils in bronchoalveolar lavage (BAL) fluids, which was however fully abolished in the presence of a chemical antagonist of the KC/IL-8 receptors CXCR1/CXCR2, thus supporting the functional and crucial involvement of KC in BP-induced lung inflammation.	Benzo(a)pyrene	266-268	C-X-C motif chemokine receptor 1	Homo sapiens	189-194
18289803-8	2008	Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical.	Benzo(a)pyrene	81-83	aryl hydrocarbon receptor	Homo sapiens	33-36
18289803-8	2008	Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical.	Benzo(a)pyrene	81-83	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
18243466-0	2008	Benzo[a]pyrene-induced necrosis in the HepG(2) cells via PARP-1 activation and NAD(+) depletion.	Benzo(a)pyrene	0-14	poly(ADP-ribose) polymerase 1	Homo sapiens	57-63
18248503-0	2008	p53 gene mutations in SKH-1 mouse tumors differentially induced by UVB and combined subcarcinogenic benzo[a]pyrene and UVA.	Benzo(a)pyrene	100-114	transformation related protein 53, pseudogene	Mus musculus	0-3
18248503-17	2008	We show that individually subcarcinogenic levels of BaP and UVA synergistically induce a novel p53-mutation fingerprint.	Benzo(a)pyrene	52-55	transformation related protein 53, pseudogene	Mus musculus	95-98
18478976-0	2008	Different patterns of cyclin D1/CDK4-E2F-1/4 pathways in human embryo lung fibroblasts treated by benzo[a]pyrene at different doses.	Benzo(a)pyrene	98-112	cyclin D1	Homo sapiens	22-31
18494146-4	2008	For comparison, the gene expression pattern induced by Benz[a]pyrene (BaP) was also analyzed.	Benzo(a)pyrene	55-68	prohibitin 2	Homo sapiens	70-73
18160332-0	2008	Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX.	Benzo(a)pyrene	30-44	H2A.X variant histone	Homo sapiens	80-84
18160332-3	2008	In this study, we found that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL)-induced phosphorylation of histone H2AX (gamma-H2AX), which was recently identified as an early event after the induction of DNA double strand breaks (DSBs).	Benzo(a)pyrene	29-43	H2A.X variant histone	Homo sapiens	116-128
18160332-3	2008	In this study, we found that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL)-induced phosphorylation of histone H2AX (gamma-H2AX), which was recently identified as an early event after the induction of DNA double strand breaks (DSBs).	Benzo(a)pyrene	29-43	H2A.X variant histone	Homo sapiens	130-140
18160332-3	2008	In this study, we found that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL)-induced phosphorylation of histone H2AX (gamma-H2AX), which was recently identified as an early event after the induction of DNA double strand breaks (DSBs).	Benzo(a)pyrene	45-48	H2A.X variant histone	Homo sapiens	116-128
18160332-3	2008	In this study, we found that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL)-induced phosphorylation of histone H2AX (gamma-H2AX), which was recently identified as an early event after the induction of DNA double strand breaks (DSBs).	Benzo(a)pyrene	45-48	H2A.X variant histone	Homo sapiens	130-140
18160332-4	2008	Although BaP itself did not produce gamma-H2AX, SSL-exposed BaP significantly generated gamma-H2AX depending on the period of exposure.	Benzo(a)pyrene	60-63	H2A.X variant histone	Homo sapiens	88-98
18160332-5	2008	Furthermore, we revealed that reactive oxygen species produced by the SSL-exposed BaP mainly contributed to the generation of gamma-H2AX.	Benzo(a)pyrene	82-85	H2A.X variant histone	Homo sapiens	126-136
18160334-9	2008	The genotoxicity of BaP that is metabolically activated in V79 cells stably expressing human cytochrome P450-dependent monooxygenase (CYP1A1) as well as human epoxide hydrolase (V79-hCYP1A1-mEH) could not be detected with the comet assay performed under yellow light.	Benzo(a)pyrene	20-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	134-140
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	4-10
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	12-18
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	24-30
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	prohibitin 2	Mus musculus	72-75
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	prohibitin 2	Mus musculus	139-142
18478976-0	2008	Different patterns of cyclin D1/CDK4-E2F-1/4 pathways in human embryo lung fibroblasts treated by benzo[a]pyrene at different doses.	Benzo(a)pyrene	98-112	cyclin dependent kinase 4	Homo sapiens	32-36
18478976-0	2008	Different patterns of cyclin D1/CDK4-E2F-1/4 pathways in human embryo lung fibroblasts treated by benzo[a]pyrene at different doses.	Benzo(a)pyrene	98-112	E2F transcription factor 1	Homo sapiens	37-42
18179178-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates most of the toxic effects of numerous chlorinated (e.g., TCDD) and nonchlorinated polycyclic aromatic compounds (e.g., benzo[ a]pyrene).	Benzo(a)pyrene	212-227	aryl-hydrocarbon receptor	Mus musculus	4-29
18179178-1	2008	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates most of the toxic effects of numerous chlorinated (e.g., TCDD) and nonchlorinated polycyclic aromatic compounds (e.g., benzo[ a]pyrene).	Benzo(a)pyrene	212-227	aryl-hydrocarbon receptor	Mus musculus	31-34
17967930-12	2008	Cytochrome P450 inducers enhanced the conversion of benzo[a]pyrene to these metabolites without altering mRNA levels of major phenol-conjugating SULT forms (SULT1A1, SULT1A3, and SULT1B1).	Benzo(a)pyrene	52-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
17959292-1	2008	Food ingestion is the major route of exposure to many hydrophobic organic contaminants (HOCs) such as benzo[a]pyrene (BaP).	Benzo(a)pyrene	102-116	prohibitin 2	Homo sapiens	118-121
17418620-12	2008	Furthermore, the addition of BaP enhanced the arecoline-induced MT-1 expression (p&lt;0.05).	Benzo(a)pyrene	29-32	metallothionein 1I, pseudogene	Homo sapiens	64-68
17992686-1	2008	BACKGROUND: Studies in abstinent methamphetamine (METH) users have demonstrated reductions in brain dopamine transporter (DAT) binding potential (BP), as well as cognitive and motor deficits, but it is not yet clear whether cognitive deficits and brain DAT reductions fully reverse with sustained abstinence, or whether behavioral deficits in METH users are related to dopamine (DA) deficits.	Benzo(a)pyrene	146-148	solute carrier family 6 member 3	Homo sapiens	100-120
17992686-1	2008	BACKGROUND: Studies in abstinent methamphetamine (METH) users have demonstrated reductions in brain dopamine transporter (DAT) binding potential (BP), as well as cognitive and motor deficits, but it is not yet clear whether cognitive deficits and brain DAT reductions fully reverse with sustained abstinence, or whether behavioral deficits in METH users are related to dopamine (DA) deficits.	Benzo(a)pyrene	146-148	solute carrier family 6 member 3	Homo sapiens	122-125
17992686-7	2008	CONCLUSIONS: These results suggest a possible relationship between DAT BP and memory deficits in abstinent METH users, and lend support to the notion that METH produces lasting effects on central DA neurons in humans.	Benzo(a)pyrene	71-73	solute carrier family 6 member 3	Homo sapiens	67-70
17919675-0	2008	Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
17919675-0	2008	Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
17919675-3	2008	Time course studies showed that induction of CYP1-catalyzed E(2) metabolism persisted after the disappearance of BKF or co-exposed benzo(a)pyrene, suggesting that BKF metabolites retaining Ah receptor agonist activity were responsible for prolonged CYP1 induction.	Benzo(a)pyrene	131-145	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-49
18445313-0	2008	[Activated protein 1-cyclin D1/E2F 1 pathways involved in cell cycle changes induced by benzo (a) pyrene].	Benzo(a)pyrene	88-104	cyclin D1	Mus musculus	21-30
18445313-0	2008	[Activated protein 1-cyclin D1/E2F 1 pathways involved in cell cycle changes induced by benzo (a) pyrene].	Benzo(a)pyrene	88-104	E2F transcription factor 1	Mus musculus	31-36
18022386-0	2008	Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.	Benzo(a)pyrene	67-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	16-35
18022386-0	2008	Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.	Benzo(a)pyrene	67-81	aryl-hydrocarbon receptor repressor	Mus musculus	85-98
18022386-6	2008	AhRR(-/-) mice displayed a delayed response to skin carcinogenesis caused by benzo[a]pyrene.	Benzo(a)pyrene	77-91	aryl-hydrocarbon receptor repressor	Mus musculus	0-4
17942461-0	2008	Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53.	Benzo(a)pyrene	84-98	tumor protein p53	Homo sapiens	157-160
17904197-10	2008	On the other hand, peroxidase activities from BP and IBP fractions were 3 and 13 times higher, respectively, than those detected for the same fractions in phenol treated solutions without PEG.	Benzo(a)pyrene	46-48	peroxidase	Solanum lycopersicum	19-29
18800268-0	2008	Murine CD5+, CD8+ normal fetal liver cells enhance an immune response: benzo(a)pyrene-exposed CD5+ fetal liver cells are inhibitors.	Benzo(a)pyrene	71-85	CD5 antigen	Mus musculus	7-10
18800268-0	2008	Murine CD5+, CD8+ normal fetal liver cells enhance an immune response: benzo(a)pyrene-exposed CD5+ fetal liver cells are inhibitors.	Benzo(a)pyrene	71-85	CD5 antigen	Mus musculus	94-97
18800268-6	2008	However, liver CD5(+) cells from benzo(a)pyrene-exposed fetuses led to a dramatic reduction of the enhancing effect.	Benzo(a)pyrene	33-47	CD5 antigen	Mus musculus	15-18
18800268-7	2008	Thus, as a novel finding, it appears that the profile of CD5(+) cells, under the ontogenic influence of benzo(a)pyrene, transforms from cells that normally augment cell proliferation in an immune response to cells that are inhibitors.	Benzo(a)pyrene	104-118	CD5 antigen	Mus musculus	57-60
19105532-0	2008	Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyrene.	Benzo(a)pyrene	133-147	transformation related protein 53, pseudogene	Mus musculus	78-81
19105532-1	2008	We evaluated the mechanisms using immunohistochemistry whereby chrysotile asbestos and benzo(a)pyrene (BaP) instilled intratracheally into lung-specific dominant-negative p53 (dnp53) mice might interact in causing lung carcinomas and fibrosis.	Benzo(a)pyrene	87-101	prohibitin 2	Mus musculus	103-106
19105532-1	2008	We evaluated the mechanisms using immunohistochemistry whereby chrysotile asbestos and benzo(a)pyrene (BaP) instilled intratracheally into lung-specific dominant-negative p53 (dnp53) mice might interact in causing lung carcinomas and fibrosis.	Benzo(a)pyrene	87-101	transformation related protein 53, pseudogene	Mus musculus	171-174
18569596-4	2008	Recently in PUBEC cultures derived from pools of several bladders potent induction of CYP1A1 was detected after BaP treatment.	Benzo(a)pyrene	112-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-92
18569596-5	2008	Results from a modified approach using miniaturized PUBEC cultures for the analysis of individual bladder specimens with regard to cell growth and to BaP-mediated induction of CYP1A1 mRNA expression are presented herein.	Benzo(a)pyrene	150-153	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	176-182
18569604-0	2008	Evaluation of time dependence and interindividual differences in benzo[a]pyrene-mediated CYP1A1 induction and genotoxicity in porcine urinary bladder cell cultures.	Benzo(a)pyrene	65-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	89-95
18569604-4	2008	In a preceding study, it was demonstrated using cultured porcine urinary bladder epithelial cells (PUBEC) that CYP1A1 mRNA is induced in a potent manner by treatment with benzo[a]pyrene (BaP).	Benzo(a)pyrene	171-185	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-117
18569604-4	2008	In a preceding study, it was demonstrated using cultured porcine urinary bladder epithelial cells (PUBEC) that CYP1A1 mRNA is induced in a potent manner by treatment with benzo[a]pyrene (BaP).	Benzo(a)pyrene	187-190	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-117
18569604-8	2008	Interindividual differences were found between PUBEC cultures derived from several donor animals with respect to the response to BaP, such that the extent of CYP1A1 induction and magnitude of DNA damage was interrelated.	Benzo(a)pyrene	129-132	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	158-164
18065724-0	2008	Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line.	Benzo(a)pyrene	54-68	aryl hydrocarbon receptor	Homo sapiens	30-41
18065724-5	2008	AhR activation induces several cytochrome P450 phase I enzymes involved, e.g. in the bioactivation of carcinogenic polycyclic aromatic hydrocarbons, like benzo[a]pyrene (BaP), and may as such stimulate DNA adduct formation of those compounds.	Benzo(a)pyrene	154-168	aryl hydrocarbon receptor	Homo sapiens	0-3
18065724-5	2008	AhR activation induces several cytochrome P450 phase I enzymes involved, e.g. in the bioactivation of carcinogenic polycyclic aromatic hydrocarbons, like benzo[a]pyrene (BaP), and may as such stimulate DNA adduct formation of those compounds.	Benzo(a)pyrene	170-173	aryl hydrocarbon receptor	Homo sapiens	0-3
18065724-8	2008	Co-exposure to high AhR-activating concentrations of both TCDD and ICZ significantly reduced the amount of BaP-DNA adducts at 0.1 microM BaP, while at higher concentrations of BaP no influence was observed.	Benzo(a)pyrene	107-110	aryl hydrocarbon receptor	Homo sapiens	20-23
18065724-8	2008	Co-exposure to high AhR-activating concentrations of both TCDD and ICZ significantly reduced the amount of BaP-DNA adducts at 0.1 microM BaP, while at higher concentrations of BaP no influence was observed.	Benzo(a)pyrene	137-140	aryl hydrocarbon receptor	Homo sapiens	20-23
18065724-8	2008	Co-exposure to high AhR-activating concentrations of both TCDD and ICZ significantly reduced the amount of BaP-DNA adducts at 0.1 microM BaP, while at higher concentrations of BaP no influence was observed.	Benzo(a)pyrene	137-140	aryl hydrocarbon receptor	Homo sapiens	20-23
17665681-7	2007	The quantification of mdr49 transcripts by real-time PCR in adult flies exposed to benzo[a]pyrene over time or in presence of increasing concentrations of this pollutant showed a clear dose-dependent response.	Benzo(a)pyrene	83-97	Multi drug resistance 49	Drosophila melanogaster	22-27
17942461-7	2008	Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells.	Benzo(a)pyrene	42-45	tumor protein p53	Homo sapiens	74-77
17942461-7	2008	Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells.	Benzo(a)pyrene	42-45	tumor protein p53	Homo sapiens	126-129
17942461-8	2008	Other cell lines were investigated for BaP-DNA adduct formation and in these the effect of p53 knockdown was also to reduce adduct formation.	Benzo(a)pyrene	39-42	tumor protein p53	Homo sapiens	91-94
17942461-9	2008	Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP.	Benzo(a)pyrene	106-109	tumor protein p53	Homo sapiens	68-71
17942461-9	2008	Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP.	Benzo(a)pyrene	209-212	tumor protein p53	Homo sapiens	68-71
18054613-12	2008	CONCLUSION: A reduction of BP by 15% (SBP &lt; or =140 mm Hg, DBP &lt; or =80 mm Hg) is necessary at acute stage in S-ICH.	Benzo(a)pyrene	27-29	selenium binding protein 1	Homo sapiens	38-41
18054613-12	2008	CONCLUSION: A reduction of BP by 15% (SBP &lt; or =140 mm Hg, DBP &lt; or =80 mm Hg) is necessary at acute stage in S-ICH.	Benzo(a)pyrene	27-29	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
17944540-0	2007	AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.	Benzo(a)pyrene	66-80	aryl hydrocarbon receptor	Homo sapiens	0-3
17944540-2	2007	Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	89-114
17944540-2	2007	Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage.	Benzo(a)pyrene	0-14	aryl hydrocarbon receptor	Homo sapiens	116-119
17944540-2	2007	Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	89-114
17944540-2	2007	Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage.	Benzo(a)pyrene	16-19	aryl hydrocarbon receptor	Homo sapiens	116-119
17944540-3	2007	To characterize further the expression profiles induced by BaP in HepG2 and MCF-7 cells obtained in our previous study, they were compared to those induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which activates AHR but does not bind to DNA, and anti-benzo(a)pyrene- trans-7,8-dihydrodiol-9,10-epoxide (BPDE), which binds directly to DNA but does not activate AHR.	Benzo(a)pyrene	59-62	aryl hydrocarbon receptor	Homo sapiens	219-222
17944540-3	2007	To characterize further the expression profiles induced by BaP in HepG2 and MCF-7 cells obtained in our previous study, they were compared to those induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which activates AHR but does not bind to DNA, and anti-benzo(a)pyrene- trans-7,8-dihydrodiol-9,10-epoxide (BPDE), which binds directly to DNA but does not activate AHR.	Benzo(a)pyrene	59-62	aryl hydrocarbon receptor	Homo sapiens	367-370
17944540-10	2007	Furthermore, some genes were modulated by BaP but not by TCDD or BPDE, including induction of CRY1 and MAK, which may represent novel signaling pathways that are independent of both AHR activation and DNA damage.	Benzo(a)pyrene	42-45	cryptochrome circadian regulator 1	Homo sapiens	94-98
17944540-10	2007	Furthermore, some genes were modulated by BaP but not by TCDD or BPDE, including induction of CRY1 and MAK, which may represent novel signaling pathways that are independent of both AHR activation and DNA damage.	Benzo(a)pyrene	42-45	male germ cell associated kinase	Homo sapiens	103-106
17944540-10	2007	Furthermore, some genes were modulated by BaP but not by TCDD or BPDE, including induction of CRY1 and MAK, which may represent novel signaling pathways that are independent of both AHR activation and DNA damage.	Benzo(a)pyrene	42-45	aryl hydrocarbon receptor	Homo sapiens	182-185
17991490-1	2007	Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS).	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	23-43
17991490-1	2007	Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS).	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	45-51
17991490-1	2007	Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS).	Benzo(a)pyrene	0-14	nitric oxide synthase 2	Rattus norvegicus	138-169
17991490-1	2007	Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS).	Benzo(a)pyrene	0-14	nitric oxide synthase 2	Rattus norvegicus	171-175
17991490-2	2007	In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-treated rat PMNs was investigated.	Benzo(a)pyrene	125-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	74-80
17991490-2	2007	In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-treated rat PMNs was investigated.	Benzo(a)pyrene	125-139	nitric oxide synthase 2	Rattus norvegicus	106-110
17991490-5	2007	A significant elevation in CYP1A1 and [Ca(2+)]i was observed in benzo(a)pyrene-treated rat PMNs, which was significantly restored by alpha-naphthoflavone or genistein.	Benzo(a)pyrene	64-78	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	27-33
17991490-8	2007	Benzo(a)pyrene-augmented iNOS expression and activity in PMNs were significantly reverse by felodipine, genistein, or PDTC.	Benzo(a)pyrene	0-14	nitric oxide synthase 2	Rattus norvegicus	25-29
17991490-9	2007	Benzo(a)pyrene also induced TNF-alpha and IL-1beta production in PMNs, which was significantly reversed by genistein.	Benzo(a)pyrene	0-14	tumor necrosis factor	Rattus norvegicus	28-37
17991490-9	2007	Benzo(a)pyrene also induced TNF-alpha and IL-1beta production in PMNs, which was significantly reversed by genistein.	Benzo(a)pyrene	0-14	interleukin 1 beta	Rattus norvegicus	42-50
17942115-0	2007	Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.	Benzo(a)pyrene	14-28	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	59-62
17942115-0	2007	Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.	Benzo(a)pyrene	14-28	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	111-114
17722167-6	2007	The reported concentration of inhibitor needed to reduce at 50% ACE activity (IC(50)) values for single BP calculated in inhibiting the ACE enzyme gave results in agreement with the same parameters available in literature for other milk-derived BPs.	Benzo(a)pyrene	104-106	angiotensin I converting enzyme	Bos taurus	64-67
17722167-6	2007	The reported concentration of inhibitor needed to reduce at 50% ACE activity (IC(50)) values for single BP calculated in inhibiting the ACE enzyme gave results in agreement with the same parameters available in literature for other milk-derived BPs.	Benzo(a)pyrene	104-106	angiotensin I converting enzyme	Bos taurus	136-139
17900831-0	2007	Dynamic changes of XPA, XPC, XPF, XPG and ERCC1 protein expression and their correlations with levels of DNA damage in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	162-176	XPA, DNA damage recognition and repair factor	Homo sapiens	19-22
17900831-0	2007	Dynamic changes of XPA, XPC, XPF, XPG and ERCC1 protein expression and their correlations with levels of DNA damage in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	162-176	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	24-27
17900831-0	2007	Dynamic changes of XPA, XPC, XPF, XPG and ERCC1 protein expression and their correlations with levels of DNA damage in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	162-176	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	29-32
17900831-0	2007	Dynamic changes of XPA, XPC, XPF, XPG and ERCC1 protein expression and their correlations with levels of DNA damage in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	162-176	ERCC excision repair 5, endonuclease	Homo sapiens	34-37
17900831-0	2007	Dynamic changes of XPA, XPC, XPF, XPG and ERCC1 protein expression and their correlations with levels of DNA damage in human bronchial epithelia cells exposed to benzo[a]pyrene.	Benzo(a)pyrene	162-176	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	42-47
17900831-6	2007	ERCC1 expression increased by 2.4-, 4.2- and 19.3-fold for exposure to 2, 8 and 16microM BaP, respectively, compared with control group.	Benzo(a)pyrene	89-92	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	0-5
17900831-7	2007	Moreover, levels of ERCC1 in cells exposed 16microM BaP significantly higher than those in 2 and 8microM BaP from 2nd to 48th hours.	Benzo(a)pyrene	52-55	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	20-25
17900831-7	2007	Moreover, levels of ERCC1 in cells exposed 16microM BaP significantly higher than those in 2 and 8microM BaP from 2nd to 48th hours.	Benzo(a)pyrene	105-108	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	20-25
17900831-8	2007	In addition, there was a significant positive correlation between Olive tail moments and relative ratios of ERCC1 in cells exposed to BaP.	Benzo(a)pyrene	134-137	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	108-113
17900183-2	2007	Complexes [EuL(1-3)] incorporate N10-CH2CONH-BP linkers (BP = benzophenone), which allow formation of a five-membered chelate ring containing the metal ion upon chelation of the amide oxygen; these three isomeric complexes differ from one another in the substitution position of the BP unit, namely para, meta, and ortho for L1, L2, and L3 respectively.	Benzo(a)pyrene	45-47	L1 cell adhesion molecule	Homo sapiens	325-339
17678638-8	2007	By contrast to numerous DNA damaging agents such as BaP which is known to stimulate p53 expression, the lack of p53 response by 6-NC imply the lack of protective functions mediated by p53 (e.g. DNA repair machinery) after exposure to 6-NC and this may, in part, account for its remarkable carcinogenicity in the mammary tissue.	Benzo(a)pyrene	52-55	tumor protein p53	Homo sapiens	84-87
17522069-3	2007	To provide direct evidence for NFAT3 in the environmental carcinogen-caused carcinogenic effect, (+/-)-benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), an ultimate environmental carcinogen metabolized from benzo[a]pyrene, was utilized.	Benzo(a)pyrene	103-117	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	31-36
17909020-2	2007	In the present study, we show that exposure of diploid mouse embryonic fibroblasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) resulted in a concentration- and time-dependent increase in Cdc25B protein levels.	Benzo(a)pyrene	121-135	cell division cycle 25B	Mus musculus	235-241
17909020-2	2007	In the present study, we show that exposure of diploid mouse embryonic fibroblasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) resulted in a concentration- and time-dependent increase in Cdc25B protein levels.	Benzo(a)pyrene	137-139	cell division cycle 25B	Mus musculus	235-241
17909020-5	2007	Furthermore, a carcinogenic dose of the parent hydrocarbon (BP) increased Cdc25B protein levels in the target organ, lung.	Benzo(a)pyrene	60-62	cell division cycle 25B	Mus musculus	74-80
17909032-3	2007	Glutathione transferase pi (GSTP) catalyzes the detoxification of electrophilic diol epoxides produced by the metabolism of polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke.	Benzo(a)pyrene	165-179	prohibitin 2	Mus musculus	181-184
17915553-6	2007	HSPA5 mRNA was induced by 3 microM BaP in an AD-sensitive manner, but this response was unaffected by the presence of heavy metals.	Benzo(a)pyrene	35-38	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-5
17640999-0	2007	Benzo[a]pyrene induces apoptosis in RL95-2 human endometrial cancer cells by cytochrome P450 1A1 activation.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	77-96
17903170-2	2007	Activation of the AHR by the genotoxic carcinogen benzo(a)pyrene (BaP) increased L1 expression in human cervical carcinoma (HeLa) cells, human microvascular endothelial cells (HMEC), mouse vascular smooth muscle cells (mVSMC) and mouse embryonic kidney cells (mK4).	Benzo(a)pyrene	50-64	aryl hydrocarbon receptor	Homo sapiens	18-21
17903170-2	2007	Activation of the AHR by the genotoxic carcinogen benzo(a)pyrene (BaP) increased L1 expression in human cervical carcinoma (HeLa) cells, human microvascular endothelial cells (HMEC), mouse vascular smooth muscle cells (mVSMC) and mouse embryonic kidney cells (mK4).	Benzo(a)pyrene	50-64	prohibitin 2	Homo sapiens	66-69
17682057-3	2007	To test this hypothesis, we coexposed cells to binary mixtures of benzo[a]pyrene (B[a]P), an environmental procarcinogen that activates Cyp1a1 transcriptional responses mediated by the aryl hydrocarbon receptor (AHR), and chromium, a carcinogenic heavy metal that represses B[a]P-inducible AHR-mediated gene expression.	Benzo(a)pyrene	66-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	136-142
17682057-3	2007	To test this hypothesis, we coexposed cells to binary mixtures of benzo[a]pyrene (B[a]P), an environmental procarcinogen that activates Cyp1a1 transcriptional responses mediated by the aryl hydrocarbon receptor (AHR), and chromium, a carcinogenic heavy metal that represses B[a]P-inducible AHR-mediated gene expression.	Benzo(a)pyrene	66-80	aryl hydrocarbon receptor	Homo sapiens	185-210
17682057-3	2007	To test this hypothesis, we coexposed cells to binary mixtures of benzo[a]pyrene (B[a]P), an environmental procarcinogen that activates Cyp1a1 transcriptional responses mediated by the aryl hydrocarbon receptor (AHR), and chromium, a carcinogenic heavy metal that represses B[a]P-inducible AHR-mediated gene expression.	Benzo(a)pyrene	66-80	aryl hydrocarbon receptor	Homo sapiens	212-215
17682057-3	2007	To test this hypothesis, we coexposed cells to binary mixtures of benzo[a]pyrene (B[a]P), an environmental procarcinogen that activates Cyp1a1 transcriptional responses mediated by the aryl hydrocarbon receptor (AHR), and chromium, a carcinogenic heavy metal that represses B[a]P-inducible AHR-mediated gene expression.	Benzo(a)pyrene	66-80	aryl hydrocarbon receptor	Homo sapiens	290-293
17707923-1	2007	Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene.	Benzo(a)pyrene	101-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	200-206
17640307-0	2007	Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells.	Benzo(a)pyrene	185-199	prostaglandin-endoperoxide synthase 2	Homo sapiens	155-171
17583486-1	2007	The objective of this study was to investigate the morphological effects of postnatal exposure to benzo[a]pyrene (B[a]P) on the development of the uterus, uterine estrogen receptor (ERalpha) expression, and the uterine response to estrogen stimulation using the uterotrophic bioassay in rats.	Benzo(a)pyrene	98-112	estrogen receptor 1	Rattus norvegicus	163-180
17492273-0	2007	Maternal deprivation and handling modify the effect of the dopamine D3 receptor agonist, BP 897 on morphine-conditioned place preference in rats.	Benzo(a)pyrene	89-91	dopamine receptor D3	Rattus norvegicus	59-79
17681673-3	2007	Downregulation of RelB and eIF3 p170 by benzo(a)pyrene.	Benzo(a)pyrene	40-54	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	18-22
17681673-7	2007	Since the toxic effects of benzo(a)pyrene are aryl hydrocarbon receptor (AhR)-dependent, we examined the effects of the very potent AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the growth and functional differentiation of mouse BM-derived DCs.	Benzo(a)pyrene	27-41	aryl-hydrocarbon receptor	Mus musculus	73-76
17681673-15	2007	Taken together, although benzo(a)pyrene and TCDD exert their effects via binding to AhR, their effects on the growth and functional differentiation of bone marrow-derived DCs are different.	Benzo(a)pyrene	25-39	aryl-hydrocarbon receptor	Mus musculus	84-87
17561435-1	2007	This study was undertaken to investigate the genotoxic interactions between the common environmental pollutants: arsenic (As), cadmium (Cd) and benzo(a)pyrene (BaP), which are known to be human carcinogens.	Benzo(a)pyrene	144-158	prohibitin 2	Homo sapiens	160-163
17630984-5	2007	In silico docking showed alteration of the substrate access channel in exon 6 del CYP1A1 such that benzo(a)pyrene does not bind in any orientation that would permit the formation of carcinogenic metabolites.	Benzo(a)pyrene	99-113	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
17654259-1	2007	Dietary benzo[a]pyrene (BaP) levels were analyzed by high-performance liquid chromatography with fluorescence detection (HPLC-FLD) in various foods (e.g., snack, potato chip, bread, vegetable oil, meat, cereal, etc.)	Benzo(a)pyrene	8-22	prohibitin 2	Homo sapiens	24-27
17376491-0	2007	The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.	Benzo(a)pyrene	29-43	chemokine (C-C motif) ligand 2	Mus musculus	66-100
17376491-2	2007	Previously we showed that chronic exposure of ApoE-/- mice to the prototype PAH benzo[a]pyrene (B[a]P) causes enhanced progression of atherosclerosis, which was characterised by an increased inflammatory cell content in the atherosclerotic plaques.	Benzo(a)pyrene	80-94	apolipoprotein E	Mus musculus	46-50
17376491-5	2007	Initially we performed in vivo studies showing that acute treatment with B[a]P induces MCP-1 gene expression in aortic tissue of ApoE-/- mice.	Benzo(a)pyrene	73-78	chemokine (C-C motif) ligand 2	Mus musculus	87-92
17376491-5	2007	Initially we performed in vivo studies showing that acute treatment with B[a]P induces MCP-1 gene expression in aortic tissue of ApoE-/- mice.	Benzo(a)pyrene	73-78	apolipoprotein E	Mus musculus	129-133
17408918-0	2007	Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach.	Benzo(a)pyrene	30-44	ATP binding cassette subfamily B member 1	Homo sapiens	48-62
17408918-1	2007	The previous studies from our laboratory reported that benzo(a)pyrene (Bap) influenced efflux transport of rhodamine 123 (Rho-123) by induction of P-glycoprotein (P-gp) in Caco-2 cells.	Benzo(a)pyrene	55-69	ATP binding cassette subfamily B member 1	Homo sapiens	147-161
17408918-1	2007	The previous studies from our laboratory reported that benzo(a)pyrene (Bap) influenced efflux transport of rhodamine 123 (Rho-123) by induction of P-glycoprotein (P-gp) in Caco-2 cells.	Benzo(a)pyrene	55-69	ATP binding cassette subfamily B member 1	Homo sapiens	163-167
17408918-1	2007	The previous studies from our laboratory reported that benzo(a)pyrene (Bap) influenced efflux transport of rhodamine 123 (Rho-123) by induction of P-glycoprotein (P-gp) in Caco-2 cells.	Benzo(a)pyrene	71-74	ATP binding cassette subfamily B member 1	Homo sapiens	147-161
17408918-1	2007	The previous studies from our laboratory reported that benzo(a)pyrene (Bap) influenced efflux transport of rhodamine 123 (Rho-123) by induction of P-glycoprotein (P-gp) in Caco-2 cells.	Benzo(a)pyrene	71-74	ATP binding cassette subfamily B member 1	Homo sapiens	163-167
17408918-8	2007	Our results further show that Bep or Bap-induced P-gp in Caco-2 cells might have been the result of oxidative stress rather than DNA damage.	Benzo(a)pyrene	37-40	ATP binding cassette subfamily B member 1	Homo sapiens	49-53
17602818-0	2007	The Cdc25A is involved in S-phase checkpoint induced by benzo(a)pyrene.	Benzo(a)pyrene	56-70	cell division cycle 25A	Homo sapiens	4-10
17602818-3	2007	However, the role of Cdc25A in the BaP/BPDE-induced checkpoint is not clear.	Benzo(a)pyrene	35-38	cell division cycle 25A	Homo sapiens	21-27
17602818-4	2007	In the present study, we investigated the change of checkpoint kinase 1 (Chk1) and Cdc25A in S-phase arrest elicited by BaP.	Benzo(a)pyrene	120-123	checkpoint kinase 1	Homo sapiens	52-71
17602818-4	2007	In the present study, we investigated the change of checkpoint kinase 1 (Chk1) and Cdc25A in S-phase arrest elicited by BaP.	Benzo(a)pyrene	120-123	checkpoint kinase 1	Homo sapiens	73-77
17602818-4	2007	In the present study, we investigated the change of checkpoint kinase 1 (Chk1) and Cdc25A in S-phase arrest elicited by BaP.	Benzo(a)pyrene	120-123	cell division cycle 25A	Homo sapiens	83-89
17602818-7	2007	The level of phorsphorylated Chk1 obviously increased and Cdc25A protein level decreased in both two cell lines after treatment with BaP.	Benzo(a)pyrene	133-136	checkpoint kinase 1	Homo sapiens	29-33
17602818-7	2007	The level of phorsphorylated Chk1 obviously increased and Cdc25A protein level decreased in both two cell lines after treatment with BaP.	Benzo(a)pyrene	133-136	cell division cycle 25A	Homo sapiens	58-64
17602818-10	2007	Over all, our results indicated Chk1-Cdc25A checkpoint pathway is involved in BaP-induced S-phase arrest.	Benzo(a)pyrene	78-81	checkpoint kinase 1	Homo sapiens	32-36
17602818-10	2007	Over all, our results indicated Chk1-Cdc25A checkpoint pathway is involved in BaP-induced S-phase arrest.	Benzo(a)pyrene	78-81	cell division cycle 25A	Homo sapiens	37-43
17590295-6	2007	BP caused severe liver injury in rats, as indicated by elevated plasma ALT, AST and LPO levels.	Benzo(a)pyrene	0-2	lactoperoxidase	Rattus norvegicus	84-87
17590295-7	2007	Pretreatment with WG for 4 weeks completely abrogated increases in the ALT, AST and LPO levels when challenged with BP.	Benzo(a)pyrene	116-118	lactoperoxidase	Rattus norvegicus	84-87
17272310-1	2007	Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis.	Benzo(a)pyrene	76-90	prohibitin 2	Homo sapiens	92-95
17699488-6	2007	In patients with primary aldosteronism, plasma active renin levels that were higher than the lower limit of detection (2.5 pg/ml) were associated with higher BP, plasma potassium, and albuminuria and lower creatinine clearance.	Benzo(a)pyrene	158-160	renin	Homo sapiens	54-59
17699488-9	2007	During follow-up, patients with higher baseline plasma renin required use of more antihypertensive drugs to obtain BP control and had a smaller early decline in albuminuria than did patients with suppressed renin.	Benzo(a)pyrene	115-117	renin	Homo sapiens	55-60
17596880-11	2007	Finally, CAR was also up-regulated in primary human hepatocytes in response to AhR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo[a]pyrene.	Benzo(a)pyrene	137-151	nuclear receptor subfamily 1 group I member 3	Homo sapiens	9-12
17596880-11	2007	Finally, CAR was also up-regulated in primary human hepatocytes in response to AhR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo[a]pyrene.	Benzo(a)pyrene	137-151	aryl hydrocarbon receptor	Homo sapiens	79-82
17908424-1	2007	OBJECTIVE: To investigate the role of mitogen activated protein kinases (MAPKs) signaling pathways in the regulation of benzo(a)pyrene (B(a)P)-induced c-Jun activation in human embryo lung fibroblasts (HELFs).	Benzo(a)pyrene	120-134	prohibitin 2	Homo sapiens	136-141
17403528-2	2007	The GSTM1 null allele was associated with significantly higher levels of two biomarkers, malondialdehyde-2"-deoxyguanosine and benzo[a]pyrene DNA adducts in the total population from three Central and Eastern European countries.	Benzo(a)pyrene	127-141	glutathione S-transferase mu 1	Homo sapiens	4-9
17908424-1	2007	OBJECTIVE: To investigate the role of mitogen activated protein kinases (MAPKs) signaling pathways in the regulation of benzo(a)pyrene (B(a)P)-induced c-Jun activation in human embryo lung fibroblasts (HELFs).	Benzo(a)pyrene	120-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	151-156
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 3	Homo sapiens	139-143
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 3	Homo sapiens	163-169
17651059-2	2007	In the present study, an anthocyanin-rich extract from Concord grapes [referred to as Concord grape extract (CGE)] and the anthocyanin delphinidin were evaluated for their capacity to inhibit DNA adduct formation due to the environmental carcinogen benzo[a]pyrene (BP) in MCF-10F cells, a noncancerous, immortalized human breast epithelial cell line.	Benzo(a)pyrene	249-263	DDB1 and CUL4 associated factor 7	Homo sapiens	25-36
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 8	Homo sapiens	171-177
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 3	Homo sapiens	281-285
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 3	Homo sapiens	139-143
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 3	Homo sapiens	163-169
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 8	Homo sapiens	171-177
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 1	Homo sapiens	182-185
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 3	Homo sapiens	281-285
17959047-2	2007	METHODS: The phosphorylation of MAPK were induced by exposing HELF cells to BaP at 0.1, 0.5, 2.5 and 12.5 micromol/L.	Benzo(a)pyrene	76-79	mitogen-activated protein kinase 3	Homo sapiens	32-36
17959047-4	2007	And the flow cytometry assay was used to measure the cell cycle effects in HELF cells after treatment with 2.5 micromol/L BaP for 24 h. RESULTS: The phosphorylation levels of ERK1/2, JNK1/2 and p38 were significantly increased through BaP exposure.	Benzo(a)pyrene	122-125	mitogen-activated protein kinase 3	Homo sapiens	175-181
17959047-7	2007	Three chemical inhibitors of MAPK (AG126, SP600125 and SB203580) could significantly inhibit the cell cycle alteration because of BaP treatment.	Benzo(a)pyrene	130-133	mitogen-activated protein kinase 3	Homo sapiens	29-33
17959047-8	2007	CONCLUSION: ERK1/2, JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations.	Benzo(a)pyrene	65-68	mitogen-activated protein kinase 3	Homo sapiens	12-18
17959047-8	2007	CONCLUSION: ERK1/2, JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations.	Benzo(a)pyrene	65-68	mitogen-activated protein kinase 8	Homo sapiens	20-26
17959047-8	2007	CONCLUSION: ERK1/2, JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations.	Benzo(a)pyrene	65-68	mitogen-activated protein kinase 1	Homo sapiens	31-34
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	39-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	39-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	39-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	39-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	55-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	55-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	55-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
17575130-6	2007	A single intratracheal instillation of benzo(a)pyrene (BaP) increased the lung mutation frequency 3.1- and 6.1-fold in nrf2+/- and nrf2-/- mice, respectively, compared with BaP-untreated nrf2+/- mice, showing that nrf2-/- mice are more susceptible to genotoxic carcinogens.	Benzo(a)pyrene	55-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
17575130-7	2007	Surprisingly, mutation profiles of the gpt gene in BaP-treated nrf2+/- mice was substantially different from that in BaP-untreated nrf2-/- mice.	Benzo(a)pyrene	51-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
17575130-8	2007	In nrf2-/- mice, spontaneous and BaP-induced mutation hotspots were observed at nucleotides 64 and 140 of gpt, respectively.	Benzo(a)pyrene	33-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	3-7
17433523-0	2007	Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.	Benzo(a)pyrene	51-65	aryl-hydrocarbon receptor	Mus musculus	13-38
17433523-0	2007	Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.	Benzo(a)pyrene	51-65	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	107-113
17433523-2	2007	In this study, we showed that B[a]P induces apoptosis in a p53-mediated and caspase-3-dependent manner, which relates to the accumulation of the S phase of the cell cycle.	Benzo(a)pyrene	30-35	transformation related protein 53, pseudogene	Mus musculus	59-62
17433523-2	2007	In this study, we showed that B[a]P induces apoptosis in a p53-mediated and caspase-3-dependent manner, which relates to the accumulation of the S phase of the cell cycle.	Benzo(a)pyrene	30-35	caspase 3	Mus musculus	76-85
17442277-3	2007	But the effects of BaP and its metabolites on VEGF and HIF-1 expression remain to be elucidated.	Benzo(a)pyrene	19-22	vascular endothelial growth factor A	Homo sapiens	46-50
17442277-3	2007	But the effects of BaP and its metabolites on VEGF and HIF-1 expression remain to be elucidated.	Benzo(a)pyrene	19-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-60
17651059-2	2007	In the present study, an anthocyanin-rich extract from Concord grapes [referred to as Concord grape extract (CGE)] and the anthocyanin delphinidin were evaluated for their capacity to inhibit DNA adduct formation due to the environmental carcinogen benzo[a]pyrene (BP) in MCF-10F cells, a noncancerous, immortalized human breast epithelial cell line.	Benzo(a)pyrene	249-263	DDB1 and CUL4 associated factor 7	Homo sapiens	123-134
17651059-2	2007	In the present study, an anthocyanin-rich extract from Concord grapes [referred to as Concord grape extract (CGE)] and the anthocyanin delphinidin were evaluated for their capacity to inhibit DNA adduct formation due to the environmental carcinogen benzo[a]pyrene (BP) in MCF-10F cells, a noncancerous, immortalized human breast epithelial cell line.	Benzo(a)pyrene	265-267	DDB1 and CUL4 associated factor 7	Homo sapiens	123-134
17196890-4	2007	Injection (icv) of ET-1(1-31) (500 pmol) produced a biphasic blood pressure response: an initial increase (from 118+/-8 to 138+/-14 mmHg, P&lt;0.05) followed by a sustained decrease in BP (from 118+/-8 to 58+/-9 mmHg, P&lt;0.05), which was very similar to BP response to icv injection of big ET-1 (500 pmol) or ET-1(1-21) (25 pmol)(.)	Benzo(a)pyrene	185-187	endothelin 1	Rattus norvegicus	19-23
17562481-6	2007	With regards to the liver and gastrointestinal tract, Nrf2 knockout mice are more susceptible to acetaminophen-induced hepatocellular injury, benzo[a]pyrene-induced tumor formation and Fas- and TNFalpha -mediated hepatocellular apoptosis.	Benzo(a)pyrene	142-156	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
17573710-0	2007	Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.	Benzo(a)pyrene	0-14	nuclear factor kappa B subunit 1	Homo sapiens	61-70
17573710-0	2007	Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.	Benzo(a)pyrene	0-14	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-79
17573710-1	2007	The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied.	Benzo(a)pyrene	73-87	nuclear factor kappa B subunit 1	Homo sapiens	118-127
17573710-1	2007	The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied.	Benzo(a)pyrene	73-87	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
17573710-1	2007	The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied.	Benzo(a)pyrene	89-91	nuclear factor kappa B subunit 1	Homo sapiens	118-127
17573710-1	2007	The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied.	Benzo(a)pyrene	89-91	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
17573710-3	2007	The transcription factor NF-kappaB was activated only in the hepatoma 27 cells by BP treatment but not by its noncarcinogenic isomer benzo[e]pyrene (BeP).	Benzo(a)pyrene	82-84	nuclear factor kappa B subunit 1	Homo sapiens	25-34
17573710-4	2007	Conversely to NF-kappaB activation the transcription factor AP-1 was activated in the hepatoma HepG2 cells by cell treatment with BP but not in the hepatoma 27 cells.	Benzo(a)pyrene	130-132	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
17573710-5	2007	It is concluded that the NF-kappaB activation is caused by nonmetabolized BP molecule and not related to activation of the Ah-receptor.	Benzo(a)pyrene	74-76	nuclear factor kappa B subunit 1	Homo sapiens	25-34
17573710-6	2007	The transcription factor AP-1 seems to be activated as a result of the interaction of BP with the Ah-receptor.	Benzo(a)pyrene	86-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
17573710-6	2007	The transcription factor AP-1 seems to be activated as a result of the interaction of BP with the Ah-receptor.	Benzo(a)pyrene	86-88	aryl hydrocarbon receptor	Homo sapiens	98-109
17485391-2	2007	Benz(a)pyrene and nitrosamine, typical carcinogens in cigarette smoke, undergo metabolic activation by the phase I enzymes, such as cytochrome P450 (CYP) 1A1, CYP2A6 and CYP2E1.	Benzo(a)pyrene	0-13	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-157
17485391-2	2007	Benz(a)pyrene and nitrosamine, typical carcinogens in cigarette smoke, undergo metabolic activation by the phase I enzymes, such as cytochrome P450 (CYP) 1A1, CYP2A6 and CYP2E1.	Benzo(a)pyrene	0-13	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	159-165
17485391-2	2007	Benz(a)pyrene and nitrosamine, typical carcinogens in cigarette smoke, undergo metabolic activation by the phase I enzymes, such as cytochrome P450 (CYP) 1A1, CYP2A6 and CYP2E1.	Benzo(a)pyrene	0-13	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	170-176
17409317-2	2007	However, the current use of renin-angiotensin-system intervention is targeted to BP only.	Benzo(a)pyrene	81-83	renin	Homo sapiens	28-33
17397927-0	2007	Modulation of behavior and NMDA-R1 gene mRNA expression in adult female mice after sub-acute administration of benzo(a)pyrene.	Benzo(a)pyrene	111-125	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	27-34
17397927-1	2007	The behavioral performances of adult mice exposed to sub-acute doses of benzo(a)pyrene (B(a)P) were monitored in tests related to learning and memory (Y maze and Morris water maze), locomotor activity (open-field test) and motor coordination (Locotronic apparatus).	Benzo(a)pyrene	72-86	prohibitin 2	Mus musculus	88-93
17381124-4	2007	The main difference between these two classes of cachacas is in the quantitative profile of the most potent carcinogenic PAH, benzo[a]pyrene, which is more abundant in cachaca produced from burned sugar cane crops (4.54 x 10(-2) microg L(-1)) than in cachaca produced from nonburned crops (9.02 x 10(-3) microg L(-1)).	Benzo(a)pyrene	126-140	phenylalanine hydroxylase	Homo sapiens	121-124
17292933-1	2007	Mechanisms of benzo(a)pyrene (BaP)-mediated toxicity and chemopreventative potential of quercetin in prostate cancer are poorly understood.	Benzo(a)pyrene	14-28	prohibitin 2	Homo sapiens	30-33
17229588-4	2007	Our data showed that IAP2 was significantly induced by COF, BaP, and 2,4-DDE, but XIAP was decreased by COF and 2,4-DDE, but not by BaP.	Benzo(a)pyrene	60-63	baculoviral IAP repeat containing 2	Homo sapiens	21-25
17258279-5	2007	The risk evaluation due to PAH ingestion via breast milk was assessed on the basis of the acceptable daily intake of Benzo(a)pyrene in drinking water, evidencing that a hazard cannot be excluded for heavy smokers residing in urban areas.	Benzo(a)pyrene	117-131	phenylalanine hydroxylase	Homo sapiens	27-30
17126885-1	2007	A high degradation extent of benzo[a]pyrene (BaP) should not be considered as the sole desirable criterion for the bioremediation of BaP-contaminated soils because some of its accumulated metabolites still have severe health risks to human.	Benzo(a)pyrene	29-43	prohibitin 2	Homo sapiens	45-48
17077187-1	2007	We have previously reported that breast cancer resistance protein (BCRP) is involved in the transport of phase II metabolites of the food carcinogen benzo[a]pyrene (BP) in the human intestinal cell line Caco-2.	Benzo(a)pyrene	149-163	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	33-65
17077187-1	2007	We have previously reported that breast cancer resistance protein (BCRP) is involved in the transport of phase II metabolites of the food carcinogen benzo[a]pyrene (BP) in the human intestinal cell line Caco-2.	Benzo(a)pyrene	149-163	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	67-71
17077187-1	2007	We have previously reported that breast cancer resistance protein (BCRP) is involved in the transport of phase II metabolites of the food carcinogen benzo[a]pyrene (BP) in the human intestinal cell line Caco-2.	Benzo(a)pyrene	165-167	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	33-65
17077187-1	2007	We have previously reported that breast cancer resistance protein (BCRP) is involved in the transport of phase II metabolites of the food carcinogen benzo[a]pyrene (BP) in the human intestinal cell line Caco-2.	Benzo(a)pyrene	165-167	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	67-71
17261025-5	2007	Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 &gt; CYP1A2 &gt; CYP1A1 &gt; CYP2E1 &gt; myoglobin, the same as the order of their metabolic activity.	Benzo(a)pyrene	6-20	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	120-126
17261025-5	2007	Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 &gt; CYP1A2 &gt; CYP1A1 &gt; CYP2E1 &gt; myoglobin, the same as the order of their metabolic activity.	Benzo(a)pyrene	6-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	132-138
17261025-5	2007	Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 &gt; CYP1A2 &gt; CYP1A1 &gt; CYP2E1 &gt; myoglobin, the same as the order of their metabolic activity.	Benzo(a)pyrene	6-20	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	144-150
17261025-5	2007	Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 &gt; CYP1A2 &gt; CYP1A1 &gt; CYP2E1 &gt; myoglobin, the same as the order of their metabolic activity.	Benzo(a)pyrene	6-20	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	156-162
16906435-2	2007	Naphthalene, phenanthrene, pyrene, chrysene, and benzo[a]pyrene (BaP) were administered to rats for 3 days (25-128 mg/kg/day) and the responses compared with those of model inducers.	Benzo(a)pyrene	49-63	prohibitin 2	Rattus norvegicus	65-68
17253627-1	2007	Benzo[a]pyrene (BaP) is listed as a priority pollutant by the U.S. Environmental Protection Agency because it is one of the most potent carcinogens of all known polycyclic aromatic hydrocarbons (PAHs).	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
17287431-12	2007	These data show for the first time that in transgenic mice that overexpress human ET-1, additional knockout of eNOS results in a further enhancement of BP as compared with eNOS-/- mice.	Benzo(a)pyrene	152-154	endothelin 1	Homo sapiens	82-86
16914202-11	2007	PRAME was monitorised in eight cases during follow-up: in three cases PRAME was negative at CP and expression developed at the AP/BP disease.	Benzo(a)pyrene	130-132	PRAME nuclear receptor transcriptional regulator	Homo sapiens	0-5
17237483-1	2007	Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases.	Benzo(a)pyrene	25-39	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	202-217
17077187-10	2007	In conclusion, apart from the modulation of detoxifying enzymes in the intestine, induction of BCRP by dietary constituents may contribute to the detoxification of food-derived procarcinogens such as BP.	Benzo(a)pyrene	200-202	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	95-99
16924228-3	2007	We first determined whether benzo[a]pyrene (B[a]P)- and CSC-induced levels of APC are capable of inhibiting long-patch base excision repair (LP-BER) since our earlier studies had shown that an interaction of APC with DNA polymerase beta (pol-beta) blocks strand-displacement synthesis.	Benzo(a)pyrene	28-42	DNA polymerase beta	Homo sapiens	217-236
16924228-3	2007	We first determined whether benzo[a]pyrene (B[a]P)- and CSC-induced levels of APC are capable of inhibiting long-patch base excision repair (LP-BER) since our earlier studies had shown that an interaction of APC with DNA polymerase beta (pol-beta) blocks strand-displacement synthesis.	Benzo(a)pyrene	28-42	DNA polymerase beta	Homo sapiens	238-246
17275222-1	2007	Downregulation of RelB and eIF3 p170 by benzo(a)pyrene.	Benzo(a)pyrene	40-54	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	18-22
17275222-3	2007	1 microM BP dramatically inhibited growth of BM cultured in the presence of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4).	Benzo(a)pyrene	9-11	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	76-124
17275222-3	2007	1 microM BP dramatically inhibited growth of BM cultured in the presence of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4).	Benzo(a)pyrene	9-11	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	126-132
17275222-3	2007	1 microM BP dramatically inhibited growth of BM cultured in the presence of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4).	Benzo(a)pyrene	9-11	interleukin 4	Mus musculus	138-151
17275222-3	2007	1 microM BP dramatically inhibited growth of BM cultured in the presence of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4).	Benzo(a)pyrene	9-11	interleukin 4	Mus musculus	153-157
17275222-4	2007	Although little alterations in surface expression of CD11c, major histocompatibility complex (MHC II), and CD86 molecules characteristic of mature DC were induced by BP, production of cytokines including IL-12, IL-10, and TNF-alpha, and allogeneic T cell stimulating ability were severely impaired.	Benzo(a)pyrene	166-168	integrin alpha X	Mus musculus	53-58
17275222-4	2007	Although little alterations in surface expression of CD11c, major histocompatibility complex (MHC II), and CD86 molecules characteristic of mature DC were induced by BP, production of cytokines including IL-12, IL-10, and TNF-alpha, and allogeneic T cell stimulating ability were severely impaired.	Benzo(a)pyrene	166-168	CD86 antigen	Mus musculus	107-111
17275222-5	2007	Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation.	Benzo(a)pyrene	23-25	aryl-hydrocarbon receptor	Mus musculus	70-73
17275222-5	2007	Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation.	Benzo(a)pyrene	23-25	aryl-hydrocarbon receptor	Mus musculus	109-112
17275222-5	2007	Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation.	Benzo(a)pyrene	151-153	aryl-hydrocarbon receptor	Mus musculus	70-73
17275222-5	2007	Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation.	Benzo(a)pyrene	151-153	aryl-hydrocarbon receptor	Mus musculus	109-112
17275222-6	2007	Expression of RelB, a transcription factor necessary for DC differentiation and function, and eIF3 p170, a subunit of eukaryotic translation initiation factor (eIF)3, was reduced upon BP treatment.	Benzo(a)pyrene	184-186	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	14-18
17275222-6	2007	Expression of RelB, a transcription factor necessary for DC differentiation and function, and eIF3 p170, a subunit of eukaryotic translation initiation factor (eIF)3, was reduced upon BP treatment.	Benzo(a)pyrene	184-186	eukaryotic translation initiation factor 3, subunit A	Mus musculus	160-165
17308111-0	2007	c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis.	Benzo(a)pyrene	109-123	hexokinase 2	Homo sapiens	81-94
17308111-5	2007	The aim of this study was to further elucidate how NHE1 was activated by benzo(a)pyrene (BaP) and what the downstream events were in the context of apoptosis.	Benzo(a)pyrene	73-87	solute carrier family 9 member A1	Homo sapiens	51-55
17308111-5	2007	The aim of this study was to further elucidate how NHE1 was activated by benzo(a)pyrene (BaP) and what the downstream events were in the context of apoptosis.	Benzo(a)pyrene	73-87	prohibitin 2	Homo sapiens	89-92
16530937-0	2007	Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.	Benzo(a)pyrene	56-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19
16530937-2	2007	Smoking, including exposure to polyaromatic hydrocarbons like benzo[a]pyrene (BaP), is a major risk factor.	Benzo(a)pyrene	62-76	prohibitin 2	Homo sapiens	78-81
17151860-1	2007	AIMS/HYPOTHESIS: In the current study, the effect of a highly specific peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose metabolism and BP was examined in a high-fat (HF) fed mouse model of diabetes.	Benzo(a)pyrene	163-165	glycogen synthase kinase 3 beta	Mus musculus	120-124
17237483-1	2007	Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases.	Benzo(a)pyrene	25-39	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	219-222
17237483-1	2007	Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases.	Benzo(a)pyrene	41-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	202-217
17237483-1	2007	Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases.	Benzo(a)pyrene	41-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	219-222
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	nicotinamide phosphoribosyltransferase	Homo sapiens	122-127
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	glucose-6-phosphate dehydrogenase	Homo sapiens	129-133
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	myeloperoxidase	Homo sapiens	176-179
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	BCL2 related protein A1	Homo sapiens	181-187
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	BCL2 associated X, apoptosis regulator	Homo sapiens	189-192
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	BCL2 interacting protein 3 like	Homo sapiens	199-205
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	superoxide dismutase 2	Homo sapiens	258-262
17095854-6	2007	From this functional perspective, we found differences between the CR and BP groups with regard to nucleotide metabolism (PBEF1, G6PD; p = 0.048), apoptosis (TNFAIP3, TNFAIP8, MPO, BCL2A1, BAX, SON, BNIP3L; p = 0.039) and reactive oxygen species metabolism (SOD2, KIAA0179; p = 0.048).	Benzo(a)pyrene	74-76	ribosomal RNA processing 1B	Homo sapiens	264-272
18076208-7	2007	The combination of a renin-angiotensin-aldosterone system-targeting agent, such as an ACE inhibitor or angiotensin II receptor antagonist (ARB), and a diuretic or calcium channel antagonist appears to provide synergy with regard to BP lowering.	Benzo(a)pyrene	232-234	angiotensin I converting enzyme	Homo sapiens	86-89
18076208-8	2007	In addition, ACE inhibitors and ARBs have demonstrated beneficial effects beyond BP reduction, reducing cardiovascular morbidity and mortality, inhibiting development and progression of type 2 diabetes mellitus and the progression of renal disease.	Benzo(a)pyrene	81-83	angiotensin I converting enzyme	Homo sapiens	13-16
19845073-5	2007	Representatives of both classes are now available in fixed-dose combinations containing an ACE inhibitor, the benefits of which include effective 24-hour BP control, a reduced incidence of adverse effects, and improved adherence.	Benzo(a)pyrene	154-156	angiotensin I converting enzyme	Homo sapiens	91-94
17198907-5	2007	METHODS: In the 1995-97 Nord-Trondelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and BP was evaluated in a group of 2966 nondiabetic individuals.	Benzo(a)pyrene	126-128	catechol-O-methyltransferase	Homo sapiens	112-116
16885195-0	2007	Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.	Benzo(a)pyrene	71-85	glutathione S-transferase pi 1	Homo sapiens	20-48
17163506-0	2007	A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues.	Benzo(a)pyrene	66-80	dihydrodiol dehydrogenase	Homo sapiens	20-45
17163506-3	2007	In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
17163506-3	2007	In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines.	Benzo(a)pyrene	116-130	dihydrodiol dehydrogenase	Homo sapiens	64-89
17163506-3	2007	In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines.	Benzo(a)pyrene	116-130	dihydrodiol dehydrogenase	Homo sapiens	91-94
17163506-3	2007	In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines.	Benzo(a)pyrene	132-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
17163506-3	2007	In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines.	Benzo(a)pyrene	132-135	dihydrodiol dehydrogenase	Homo sapiens	64-89
17163506-3	2007	In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines.	Benzo(a)pyrene	132-135	dihydrodiol dehydrogenase	Homo sapiens	91-94
17146658-7	2007	We analyzed data using NONMEM and studied the relationship between the AT1R 1166A/C genotypes and BP responses.	Benzo(a)pyrene	98-100	angiotensin II receptor type 1	Homo sapiens	71-75
17886062-10	2007	BaP and Phe significantly enhanced cytokine secretion (IL-4, IL-8) and histamine release from purified basophils without antigen added, and secretion was not further enhanced by rBet v 1 stimulation.	Benzo(a)pyrene	0-3	interleukin 4	Homo sapiens	55-59
17886062-10	2007	BaP and Phe significantly enhanced cytokine secretion (IL-4, IL-8) and histamine release from purified basophils without antigen added, and secretion was not further enhanced by rBet v 1 stimulation.	Benzo(a)pyrene	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
16921490-1	2007	Benzo[alpha]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), the major metabolite of benzo[a]pyrene (B[a]P), shows an ultimate complete carcinogen in various animals and is a causative agent for human cancers.	Benzo(a)pyrene	76-90	aldehyde dehydrogenase 7 family member A1	Homo sapiens	46-49
17576677-5	2007	With dG* in the less prevalent syn conformation, BP causes less distortion: it is either out of the pre-insertion site or in the major groove open pocket of the polymerase.	Benzo(a)pyrene	49-51	synemin	Homo sapiens	31-34
18001219-2	2007	We report that the AhR-ligands benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced transcription activity of COX-2 in breast cancer MCF-7 cells.	Benzo(a)pyrene	31-45	aryl hydrocarbon receptor	Homo sapiens	19-22
18001219-2	2007	We report that the AhR-ligands benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced transcription activity of COX-2 in breast cancer MCF-7 cells.	Benzo(a)pyrene	31-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	127-132
17649736-12	2007	Benz(a)pyrene boosted blood serum MDA by 190%, catalase - by 267% and 116% in tumor tissue as compared with untreated controls.	Benzo(a)pyrene	0-13	catalase	Mus musculus	47-55
16934955-3	2006	This was contrasted with the ability to modulate the benzo[a]pyrene (BaP)-dependent DNA damage in human hepatoma cells.	Benzo(a)pyrene	53-67	prohibitin 2	Homo sapiens	69-72
17424838-1	2007	OBJECTIVE: To explore the relationship between genetic polymorphisms in MPO, NQO1, GSTP1, UGT1A6 and susceptibility to chronic benzene poisoning (BP).	Benzo(a)pyrene	146-148	myeloperoxidase	Homo sapiens	72-75
17424838-10	2007	CONCLUSION: The subjects carrying allele of MPO rs7208693 A and UGT1A6 rs6759892 G or rs1105879 C at the same time could be more susceptible to BP.	Benzo(a)pyrene	144-146	myeloperoxidase	Homo sapiens	44-47
17424838-10	2007	CONCLUSION: The subjects carrying allele of MPO rs7208693 A and UGT1A6 rs6759892 G or rs1105879 C at the same time could be more susceptible to BP.	Benzo(a)pyrene	144-146	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	64-70
17424838-11	2007	The subjects carrying NQO1 rs1800566 TT genotype and together with the habit of smoking or drinking could be more susceptible to BP.	Benzo(a)pyrene	129-131	NAD(P)H quinone dehydrogenase 1	Homo sapiens	22-26
17049425-0	2006	Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice.	Benzo(a)pyrene	25-39	aryl-hydrocarbon receptor	Mus musculus	82-85
17049425-2	2006	The Ah receptor (Ahr) is involved in the metabolic activation of BP and is therefore important in the induction of chemical carcinogenesis.	Benzo(a)pyrene	65-67	aryl-hydrocarbon receptor	Mus musculus	4-15
17049425-2	2006	The Ah receptor (Ahr) is involved in the metabolic activation of BP and is therefore important in the induction of chemical carcinogenesis.	Benzo(a)pyrene	65-67	aryl-hydrocarbon receptor	Mus musculus	17-20
17049425-3	2006	In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice.	Benzo(a)pyrene	78-80	aryl-hydrocarbon receptor	Mus musculus	40-43
17049425-3	2006	In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice.	Benzo(a)pyrene	78-80	aryl-hydrocarbon receptor	Mus musculus	120-123
17049425-3	2006	In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice.	Benzo(a)pyrene	78-80	aryl-hydrocarbon receptor	Mus musculus	120-123
17049425-3	2006	In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice.	Benzo(a)pyrene	78-80	aryl-hydrocarbon receptor	Mus musculus	120-123
17049425-7	2006	There was a significant basal expression of Cyp1b1 in the liver of all genotypes, and this expression was independent of the BP exposure.	Benzo(a)pyrene	125-127	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	44-50
17049425-8	2006	Analyzed by HPLC-fluorescence, there were increased levels of protein and DNA adducts, metabolites, conjugates and unmetabolized BP in the internal organs of Ahr (-/-) as compared to Ahr (+/+) and Ahr (+/-) mice.	Benzo(a)pyrene	129-131	aryl-hydrocarbon receptor	Mus musculus	158-161
17049425-9	2006	This may be partly explained by a delayed bioactivation of BP in the Ahr deficient mice.	Benzo(a)pyrene	59-61	aryl-hydrocarbon receptor	Mus musculus	69-72
17049425-10	2006	The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP.	Benzo(a)pyrene	4-6	aryl-hydrocarbon receptor	Mus musculus	34-37
17049425-10	2006	The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP.	Benzo(a)pyrene	4-6	aryl-hydrocarbon receptor	Mus musculus	72-75
17049425-10	2006	The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP.	Benzo(a)pyrene	109-111	aryl-hydrocarbon receptor	Mus musculus	34-37
17049425-10	2006	The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP.	Benzo(a)pyrene	109-111	aryl-hydrocarbon receptor	Mus musculus	72-75
17130265-8	2006	Reduction of urinary malondialdehyde, TNF-alpha, and RANTES excretion during MMF administration did not reach statistical significance but had a direct positive correlation with the BP levels.	Benzo(a)pyrene	182-184	C-C motif chemokine ligand 5	Homo sapiens	53-59
17310841-7	2006	The activity of catalase in the serum of BP-induced tumor-bearing mice was increased by 12.1% as compared to the intact control mice (p &lt; 0.01) and was unchanged in the tumor tissue.	Benzo(a)pyrene	41-43	catalase	Mus musculus	16-24
17310841-8	2006	Treatment with melatonin at the dose of 2 mg/l significantly decreased activity of catalase in the serum (by 31.7%, p &lt; 0.01) and in the tumor tissue (by 2.6 times, p &lt; 0.01) as compared to the animals treated with BP alone.	Benzo(a)pyrene	221-223	catalase	Mus musculus	83-91
16963132-0	2006	Comparative in vitro metabolism of benzo[a]pyrene by recombinant zebrafish CYP1A and liver microsomes from beta-naphthoflavone-treated rainbow trout.	Benzo(a)pyrene	35-49	cytochrome P450, family 1, subfamily A	Danio rerio	75-80
16963132-5	2006	Results demonstrated that the trout liver microsomes were almost twice as active as zCYP1A in oxidizing BaP, with Vmax values of 1.7 and 0.94 nmol/min/nmol P450 for trout and zebrafish preparations, respectively.	Benzo(a)pyrene	104-107	cytochrome P450, family 1, subfamily A	Danio rerio	84-90
16963132-6	2006	Like trout CYP1A1, cDNA-expressed zCYP1A was found to oxidize BaP to phenols, quinones and diols (BaP-7,8-diol and BaP-9,10-diol) in the presence of exogenous human microsomal epoxide hydrolase (hEH).	Benzo(a)pyrene	62-65	cytochrome P450, family 1, subfamily A	Danio rerio	34-40
16963132-6	2006	Like trout CYP1A1, cDNA-expressed zCYP1A was found to oxidize BaP to phenols, quinones and diols (BaP-7,8-diol and BaP-9,10-diol) in the presence of exogenous human microsomal epoxide hydrolase (hEH).	Benzo(a)pyrene	62-65	epoxide hydrolase 1	Homo sapiens	165-193
16970932-5	2006	Both beta-carotene and AC at 20 microM significantly enhanced DNA strand breaks and CYP1A2 expression induced by BaP.	Benzo(a)pyrene	113-116	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	84-90
16970932-9	2006	Quercetin significantly inhibited the DNA strand breaks and the increase in CYP1A2 protein induced by AC or beta-carotene in combination with BaP or by AC alone.	Benzo(a)pyrene	142-145	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
16876476-3	2006	The initial slow segment of BP, called "early BP" in this article, begins about 2 s before the movement onset in the pre-supplementary motor area (pre-SMA) with no site-specificity and in the SMA proper according to the somatotopic organization, and shortly thereafter in the lateral premotor cortex bilaterally with relatively clear somatotopy.	Benzo(a)pyrene	28-30	survival of motor neuron 1, telomeric	Homo sapiens	151-154
16876476-3	2006	The initial slow segment of BP, called "early BP" in this article, begins about 2 s before the movement onset in the pre-supplementary motor area (pre-SMA) with no site-specificity and in the SMA proper according to the somatotopic organization, and shortly thereafter in the lateral premotor cortex bilaterally with relatively clear somatotopy.	Benzo(a)pyrene	28-30	survival of motor neuron 1, telomeric	Homo sapiens	192-195
16876476-3	2006	The initial slow segment of BP, called "early BP" in this article, begins about 2 s before the movement onset in the pre-supplementary motor area (pre-SMA) with no site-specificity and in the SMA proper according to the somatotopic organization, and shortly thereafter in the lateral premotor cortex bilaterally with relatively clear somatotopy.	Benzo(a)pyrene	46-48	survival of motor neuron 1, telomeric	Homo sapiens	151-154
16876476-3	2006	The initial slow segment of BP, called "early BP" in this article, begins about 2 s before the movement onset in the pre-supplementary motor area (pre-SMA) with no site-specificity and in the SMA proper according to the somatotopic organization, and shortly thereafter in the lateral premotor cortex bilaterally with relatively clear somatotopy.	Benzo(a)pyrene	46-48	survival of motor neuron 1, telomeric	Homo sapiens	192-195
16926039-7	2006	Furthermore, BaP increased p53 levels in both p53 positive cell lines, as well as p21 levels in MCF-7 cells, an effect that was prevented by the p53-specific inhibitor pifithrin-alpha.	Benzo(a)pyrene	13-16	tumor protein p53	Homo sapiens	27-30
16926039-7	2006	Furthermore, BaP increased p53 levels in both p53 positive cell lines, as well as p21 levels in MCF-7 cells, an effect that was prevented by the p53-specific inhibitor pifithrin-alpha.	Benzo(a)pyrene	13-16	tumor protein p53	Homo sapiens	46-49
16926039-7	2006	Furthermore, BaP increased p53 levels in both p53 positive cell lines, as well as p21 levels in MCF-7 cells, an effect that was prevented by the p53-specific inhibitor pifithrin-alpha.	Benzo(a)pyrene	13-16	tumor protein p53	Homo sapiens	46-49
17029827-4	2006	The response of phosphorylated p53 may be more sensitive towards benzo[a]pyrene exposure than normal p53.	Benzo(a)pyrene	65-79	tumor protein p53	Homo sapiens	31-34
17029827-5	2006	Following DNA damage, the activation of p53 acts as a transcriptional regulator of several target genes, including, p21 protein; a gene that encodes the Cdk inhibitor and is induced by exposure to benzo[a]pyrene.	Benzo(a)pyrene	197-211	tumor protein p53	Homo sapiens	40-43
17029827-5	2006	Following DNA damage, the activation of p53 acts as a transcriptional regulator of several target genes, including, p21 protein; a gene that encodes the Cdk inhibitor and is induced by exposure to benzo[a]pyrene.	Benzo(a)pyrene	197-211	H3 histone pseudogene 16	Homo sapiens	116-119
17029827-6	2006	The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced.	Benzo(a)pyrene	67-81	tumor protein p53	Homo sapiens	4-7
17029827-6	2006	The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced.	Benzo(a)pyrene	149-163	tumor protein p53	Homo sapiens	4-7
17029827-6	2006	The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced.	Benzo(a)pyrene	149-163	tumor protein p53	Homo sapiens	121-124
17029827-6	2006	The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced.	Benzo(a)pyrene	149-163	tumor protein p53	Homo sapiens	121-124
17029827-7	2006	The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein.	Benzo(a)pyrene	33-47	tumor protein p53	Homo sapiens	117-120
17029827-7	2006	The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein.	Benzo(a)pyrene	33-47	tumor protein p53	Homo sapiens	147-150
17029827-7	2006	The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein.	Benzo(a)pyrene	33-47	H3 histone pseudogene 16	Homo sapiens	198-201
17029827-8	2006	Oxidative DNA damage and p53 accumulation seem to be related to benzo[a]pyrene toxicity; however, their potential as biomarkers in environmental monitoring and risk assessment needs to be validated in the context of their specificity and sensitivity.	Benzo(a)pyrene	64-78	tumor protein p53	Homo sapiens	25-28
16962263-1	2006	Benzo(a)pyrene (BaP), a ubiquitous environmental pollutant known to cause many diseases including atherosclerosis, induces a dose-dependent reduction in the levels of the inducible Hsp70.	Benzo(a)pyrene	16-19	heat shock protein family A (Hsp70) member 4	Homo sapiens	181-186
16962263-3	2006	We found that when porcine aortic endothelial cells were treated by 0.1-10 microM of BaP for 24 h, there was a significant reduction of Hsp70, cytoplasmic and nuclear HSF1 and the binding rate of HSF1 and HSE at 5, 10 microM of BaP but less effective at lower concentrations.	Benzo(a)pyrene	85-88	heat shock protein family A (Hsp70) member 4	Homo sapiens	136-141
16962263-3	2006	We found that when porcine aortic endothelial cells were treated by 0.1-10 microM of BaP for 24 h, there was a significant reduction of Hsp70, cytoplasmic and nuclear HSF1 and the binding rate of HSF1 and HSE at 5, 10 microM of BaP but less effective at lower concentrations.	Benzo(a)pyrene	85-88	heat shock transcription factor 1	Homo sapiens	167-171
16962263-3	2006	We found that when porcine aortic endothelial cells were treated by 0.1-10 microM of BaP for 24 h, there was a significant reduction of Hsp70, cytoplasmic and nuclear HSF1 and the binding rate of HSF1 and HSE at 5, 10 microM of BaP but less effective at lower concentrations.	Benzo(a)pyrene	85-88	heat shock transcription factor 1	Homo sapiens	196-200
16962263-3	2006	We found that when porcine aortic endothelial cells were treated by 0.1-10 microM of BaP for 24 h, there was a significant reduction of Hsp70, cytoplasmic and nuclear HSF1 and the binding rate of HSF1 and HSE at 5, 10 microM of BaP but less effective at lower concentrations.	Benzo(a)pyrene	228-231	heat shock transcription factor 1	Homo sapiens	196-200
16962263-4	2006	The effect of BaP on the Hsp70 expression level was markedly attenuated by co-treatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Benzo(a)pyrene	14-17	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	27-30	heat shock transcription factor 1	Homo sapiens	88-92
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	27-30	heat shock transcription factor 1	Homo sapiens	119-123
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	213-218
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	241-244	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	241-244	heat shock transcription factor 1	Homo sapiens	119-123
16962263-6	2006	These results suggest that BaP might inhibit Hsp70 levels by reducing the expression of HSF1 and decreasing binding of HSF1 and HSE via PKC-dependent signaling pathways that might be involved in the regulation of Hsp70 gene expression under BaP.	Benzo(a)pyrene	241-244	heat shock protein family A (Hsp70) member 4	Homo sapiens	213-218
16899520-8	2006	These nephron segments that express WNK1-S and WNK4 mRNA have major influence on long-term NaCl reabsorption, BP, K+, and acid-base balance, processes that all are disrupted in FHHt.	Benzo(a)pyrene	110-112	WNK lysine deficient protein kinase 1	Mus musculus	36-40
16963132-8	2006	The ability of zCYP1A to bioactivate BaP was confirmed by the formation of DNA adducts when calf thymus DNA was added to the incubation mixture.	Benzo(a)pyrene	37-40	cytochrome P450, family 1, subfamily A	Danio rerio	15-21
16963132-12	2006	zCYP1A also mediated the binding of BaP to protein, providing further evidence that this enzyme is capable of oxidizing BaP to reactive metabolites that bind to macromolecules.	Benzo(a)pyrene	36-39	cytochrome P450, family 1, subfamily A	Danio rerio	0-6
16963132-12	2006	zCYP1A also mediated the binding of BaP to protein, providing further evidence that this enzyme is capable of oxidizing BaP to reactive metabolites that bind to macromolecules.	Benzo(a)pyrene	120-123	cytochrome P450, family 1, subfamily A	Danio rerio	0-6
16963132-13	2006	It thus appears that zCYP1A may play an important role in BaP-induced carcinogenesis in the zebrafish model by catalyzing the sequential formation of the ultimate diol epoxide carcinogenic metabolite of BaP.	Benzo(a)pyrene	58-61	cytochrome P450, family 1, subfamily A	Danio rerio	21-27
16963132-13	2006	It thus appears that zCYP1A may play an important role in BaP-induced carcinogenesis in the zebrafish model by catalyzing the sequential formation of the ultimate diol epoxide carcinogenic metabolite of BaP.	Benzo(a)pyrene	203-206	cytochrome P450, family 1, subfamily A	Danio rerio	21-27
17026772-4	2006	However, a current review of the English literature revealed a high rate of malignant occurrence of approximately 41% and histological analysis along with the expression pattern of mucin core proteins (MUC) and mucin carbohydrate antigens suggests that BP is a borderline or low grade malignant neoplasm with a high malignant potential.	Benzo(a)pyrene	253-255	LOC100508689	Homo sapiens	181-186
17026772-4	2006	However, a current review of the English literature revealed a high rate of malignant occurrence of approximately 41% and histological analysis along with the expression pattern of mucin core proteins (MUC) and mucin carbohydrate antigens suggests that BP is a borderline or low grade malignant neoplasm with a high malignant potential.	Benzo(a)pyrene	253-255	LOC100508689	Homo sapiens	211-216
17026772-11	2006	The clinical behavior, the high recurrence rate and the even higher malignant transformation occurrence, as well as the presence of carcinogenetic indicators (K-ras mutation, overexpression of p53, MUC and Tn antigens) strongly support that BP is a low-grade neoplasm with high malignant potential.	Benzo(a)pyrene	241-243	tumor protein p53	Homo sapiens	193-196
17250449-7	2006	Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia.	Benzo(a)pyrene	56-70	cytochrome c oxidase II, mitochondrial	Mus musculus	137-142
17250449-7	2006	Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia.	Benzo(a)pyrene	56-70	caspase 3	Mus musculus	144-153
17250449-7	2006	Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia.	Benzo(a)pyrene	56-70	caspase 7	Mus musculus	158-167
17250449-7	2006	Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia.	Benzo(a)pyrene	72-74	cytochrome c oxidase II, mitochondrial	Mus musculus	137-142
17250449-7	2006	Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia.	Benzo(a)pyrene	72-74	caspase 3	Mus musculus	144-153
17250449-7	2006	Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia.	Benzo(a)pyrene	72-74	caspase 7	Mus musculus	158-167
16596326-5	2006	XRCC1 IVS10+141G&gt;A was associated with increased expression of XRCC1 mRNA and protein, and reduced apoptosis in response to benzo-[a]-pyrene or ionizing radiation, but XRCC1 R399Q was not.	Benzo(a)pyrene	127-143	X-ray repair cross complementing 1	Homo sapiens	0-5
16933328-2	2006	The polymorphic GSTP1 gene encodes glutathione S-transferase pi, which is an enzyme that detoxifies cigarette carcinogens, such as benzo-[a]-pyrene.	Benzo(a)pyrene	131-147	glutathione S-transferase pi 1	Homo sapiens	16-21
16933328-2	2006	The polymorphic GSTP1 gene encodes glutathione S-transferase pi, which is an enzyme that detoxifies cigarette carcinogens, such as benzo-[a]-pyrene.	Benzo(a)pyrene	131-147	glutathione S-transferase kappa 1	Homo sapiens	35-60
17085896-1	2006	A brachypodism (brp) mutation arose spontaneously in the inbred NC mouse strain, producing a phenotype similar to that caused by bp mutation; therefore, it is strongly suggested that brp and bp are allelic.	Benzo(a)pyrene	191-193	growth differentiation factor 5	Mus musculus	16-19
16873418-4	2006	To investigate whether the carcinogen benzo[a]pyrene (BaP) was a CYP1C1 inducer, we used real-time PCR to quantitatively measure tissue- and sex-specific expression of both CYP1C1 and CYP1A messenger RNAs (mRNAs) in BaP-exposed adult fish.	Benzo(a)pyrene	38-52	cytochrome P450 1A1	Fundulus heteroclitus	184-189
16873418-4	2006	To investigate whether the carcinogen benzo[a]pyrene (BaP) was a CYP1C1 inducer, we used real-time PCR to quantitatively measure tissue- and sex-specific expression of both CYP1C1 and CYP1A messenger RNAs (mRNAs) in BaP-exposed adult fish.	Benzo(a)pyrene	54-57	cytochrome P450 1A1	Fundulus heteroclitus	184-189
16873418-11	2006	Our results suggest that teleost CYP1C, in addition to CYP1A, is inducible by BaP, has a broad tissue distribution, and should be further investigated for its role in carcinogen bioactivation.	Benzo(a)pyrene	78-81	cytochrome P450 1A1	Fundulus heteroclitus	55-60
16972788-3	2006	This study also shows that the AhR agonists benzo[a]pyrene, 3,3",4,4"-tetrachlorobiphenyl, chrysin, 6-methyl-1,3,8-trichlorodibenzofuran, and 3,3"-diindolylmethane also induce ERalpha-dependent transactivation.	Benzo(a)pyrene	44-58	aryl hydrocarbon receptor	Homo sapiens	31-34
16858674-9	2006	Benzo(a)pyrene caused a 15-70% inhibition in the activity of superoxide dismutase and glutathione peroxidase and an enhancement in catalase and lipid peroxidation (up to 68%) in the striatum and hippocampus at 6 and 96 h post treatment, respectively.	Benzo(a)pyrene	0-14	catalase	Rattus norvegicus	131-139
16688778-0	2006	Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells.	Benzo(a)pyrene	70-84	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	39-42
16899520-8	2006	These nephron segments that express WNK1-S and WNK4 mRNA have major influence on long-term NaCl reabsorption, BP, K+, and acid-base balance, processes that all are disrupted in FHHt.	Benzo(a)pyrene	110-112	WNK lysine deficient protein kinase 4	Mus musculus	47-51
16688778-7	2006	In conclusion, a low dose of B[a]P induced apoptosis by recruiting a large panel of executioners apparently depending on p53 phosphorylation and, for some of them, on acidification.	Benzo(a)pyrene	29-34	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	121-124
16721748-0	2006	Induction of the transferrin receptor gene by benzo[a]pyrene in breast cancer MCF-7 cells: potential as a biomarker of PAH exposure.	Benzo(a)pyrene	46-60	transferrin receptor	Homo sapiens	17-37
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-43
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	epoxide hydrolase 1	Homo sapiens	48-76
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	epoxide hydrolase 1, microsomal	Mus musculus	78-81
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	229-235
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-43
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	epoxide hydrolase 1	Homo sapiens	48-76
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	epoxide hydrolase 1, microsomal	Mus musculus	78-81
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	229-235
16484233-8	2006	BaP-induced mEH activity was not affected by treatment with 5,7-DMF, but was significantly inhibited by 3",4"-DMF.	Benzo(a)pyrene	0-3	epoxide hydrolase 1, microsomal	Mus musculus	12-15
16484233-10	2006	Most importantly, western blotting showed all three polyphenols dramatically reducing BaP-induced CYP1A1 protein expression.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104
16484233-12	2006	In summary, BaP exposure results in a high level of DNA binding in BEAS-2B cells, which is mainly mediated by induction of CYP1A1 protein, just as in the human lung.	Benzo(a)pyrene	12-15	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
16484233-13	2006	Two methoxylated dietary flavonoids with highly specific effects on BaP bioactivation block this DNA binding and CYP1A1 protein expression as effectively as RV, thus making them potential chemopreventive agents for BaP-induced lung carcinogenesis.	Benzo(a)pyrene	68-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
16769251-7	2006	The metabolism of many exogenous compounds including benzo(a)pyrene (BaP), pyrene, ethoxyresorufin, ethoxycoumarin and aniline is mediated by P450 enzymes in tissues of marine invertebrates.	Benzo(a)pyrene	53-67	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-146
16769251-7	2006	The metabolism of many exogenous compounds including benzo(a)pyrene (BaP), pyrene, ethoxyresorufin, ethoxycoumarin and aniline is mediated by P450 enzymes in tissues of marine invertebrates.	Benzo(a)pyrene	69-72	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-146
16721748-0	2006	Induction of the transferrin receptor gene by benzo[a]pyrene in breast cancer MCF-7 cells: potential as a biomarker of PAH exposure.	Benzo(a)pyrene	46-60	phenylalanine hydroxylase	Homo sapiens	119-122
16721748-4	2006	Using a GeneMAP CancerArray, we analyzed in breast cancer MCF-7 cells the temporal effects of the AhR agonist benzo[a]pyrene (B[a]P), which is a prototype PAH and known environmental carcinogen.	Benzo(a)pyrene	110-124	aryl hydrocarbon receptor	Homo sapiens	98-101
16721748-4	2006	Using a GeneMAP CancerArray, we analyzed in breast cancer MCF-7 cells the temporal effects of the AhR agonist benzo[a]pyrene (B[a]P), which is a prototype PAH and known environmental carcinogen.	Benzo(a)pyrene	110-124	phenylalanine hydroxylase	Homo sapiens	155-158
16679317-0	2006	Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.	Benzo(a)pyrene	114-128	aryl hydrocarbon receptor	Homo sapiens	0-25
16679317-0	2006	Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.	Benzo(a)pyrene	114-128	C-C motif chemokine ligand 1	Homo sapiens	76-80
16679317-3	2006	Indeed, exposure to PAHs such as benzo[a]pyrene (BP) markedly increased mRNA expression and secretion of CCL1 in primary human macrophage cultures.	Benzo(a)pyrene	33-47	C-C motif chemokine ligand 1	Homo sapiens	105-109
16679317-3	2006	Indeed, exposure to PAHs such as benzo[a]pyrene (BP) markedly increased mRNA expression and secretion of CCL1 in primary human macrophage cultures.	Benzo(a)pyrene	49-51	C-C motif chemokine ligand 1	Homo sapiens	105-109
16679317-4	2006	Moreover, intranasal administration of BP to mice enhanced mRNA levels of TCA3, the mouse orthologue of CCL1, in lung.	Benzo(a)pyrene	39-41	chemokine (C-C motif) ligand 1	Mus musculus	74-78
16679317-4	2006	Moreover, intranasal administration of BP to mice enhanced mRNA levels of TCA3, the mouse orthologue of CCL1, in lung.	Benzo(a)pyrene	39-41	chemokine (C-C motif) ligand 1	Mus musculus	104-108
16679317-6	2006	In addition, BP and the potent AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin were found to enhance activity of a CCL1 promoter sequence containing a consensus xenobiotic-responsive element known to specifically interact with AhR.	Benzo(a)pyrene	13-15	C-C motif chemokine ligand 1	Homo sapiens	115-119
16679317-6	2006	In addition, BP and the potent AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin were found to enhance activity of a CCL1 promoter sequence containing a consensus xenobiotic-responsive element known to specifically interact with AhR.	Benzo(a)pyrene	13-15	aryl hydrocarbon receptor	Homo sapiens	227-230
16679317-8	2006	In an attempt to further characterize the mechanism of CCL1 induction, we demonstrated that BP was able to induce an early and transient increase of intracellular calcium concentration in human macrophages.	Benzo(a)pyrene	92-94	C-C motif chemokine ligand 1	Homo sapiens	55-59
16889694-1	2006	OBJECTIVE: To explore the relationship between genetic polymorphisms in apurinic/apyrimidinic endonuclease (APE1) and ADP ribosyltransferase (ADPRT) and individuals" susceptibility to chronic benzene poison ing (BP).	Benzo(a)pyrene	212-214	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	108-112
16545412-2	2006	We previously demonstrated that the liver cancer susceptibility gene glycine N-methyltransferase (GNMT) is capable of binding with BaP and protecting cells from BaP-7,8-diol 9,10-epoxide-DNA adduct formation.	Benzo(a)pyrene	131-134	glycine N-methyltransferase	Homo sapiens	69-96
16545412-2	2006	We previously demonstrated that the liver cancer susceptibility gene glycine N-methyltransferase (GNMT) is capable of binding with BaP and protecting cells from BaP-7,8-diol 9,10-epoxide-DNA adduct formation.	Benzo(a)pyrene	131-134	glycine N-methyltransferase	Homo sapiens	98-102
16545412-3	2006	In this study, we used a cytotoxicity assay to demonstrate that the higher expression level of GNMT, the lower cytotoxicity occurred in the cells treated with BaP.	Benzo(a)pyrene	159-162	glycine N-methyltransferase	Homo sapiens	95-99
16545412-4	2006	In addition, a cDNA microarray containing 7,597 human genes was used to examine gene expression patterns in BaP-treated HepG2 (a liver cancer cell line that expresses very low levels of GNMT) and SCG2-1-1 (a stable HepG2 clone that expresses high levels of GNMT) cells.	Benzo(a)pyrene	108-111	glycine N-methyltransferase	Homo sapiens	186-190
16545412-4	2006	In addition, a cDNA microarray containing 7,597 human genes was used to examine gene expression patterns in BaP-treated HepG2 (a liver cancer cell line that expresses very low levels of GNMT) and SCG2-1-1 (a stable HepG2 clone that expresses high levels of GNMT) cells.	Benzo(a)pyrene	108-111	glycine N-methyltransferase	Homo sapiens	257-261
16545412-9	2006	Therefore, GNMT sequesters BaP, diminishes BaP"s effects to the liver detoxification pathway and prevents subsequent cytotoxicity.	Benzo(a)pyrene	27-30	glycine N-methyltransferase	Homo sapiens	11-15
16545412-9	2006	Therefore, GNMT sequesters BaP, diminishes BaP"s effects to the liver detoxification pathway and prevents subsequent cytotoxicity.	Benzo(a)pyrene	43-46	glycine N-methyltransferase	Homo sapiens	11-15
16751148-1	2006	A routine method was developed for the quantification of benzo[a]pyrene (BaP) in edible oils and food supplements.	Benzo(a)pyrene	57-71	prohibitin 2	Homo sapiens	73-76
16889694-1	2006	OBJECTIVE: To explore the relationship between genetic polymorphisms in apurinic/apyrimidinic endonuclease (APE1) and ADP ribosyltransferase (ADPRT) and individuals" susceptibility to chronic benzene poison ing (BP).	Benzo(a)pyrene	212-214	poly(ADP-ribose) polymerase 1	Homo sapiens	118-140
16889694-1	2006	OBJECTIVE: To explore the relationship between genetic polymorphisms in apurinic/apyrimidinic endonuclease (APE1) and ADP ribosyltransferase (ADPRT) and individuals" susceptibility to chronic benzene poison ing (BP).	Benzo(a)pyrene	212-214	poly(ADP-ribose) polymerase 1	Homo sapiens	142-147
16889694-6	2006	Compared with individuals having genotype of APE1Asp148Glu T/T without habit of alcohol consumption, there was a 4.13 times increased risk of BP for the alcohol user with genotype of APE1Asp148Glu T/T (OR = 4.13, 95% CI: 1.07 - 15.85, P = 0.03).	Benzo(a)pyrene	142-144	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	45-49
16889694-6	2006	Compared with individuals having genotype of APE1Asp148Glu T/T without habit of alcohol consumption, there was a 4.13 times increased risk of BP for the alcohol user with genotype of APE1Asp148Glu T/T (OR = 4.13, 95% CI: 1.07 - 15.85, P = 0.03).	Benzo(a)pyrene	142-144	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	183-187
16944783-0	2006	Vitamin C inhibits benzo[a]pyrene-induced cell cycle changes partly via cyclin D1/E2F pathway in human embryo lung fibroblasts.	Benzo(a)pyrene	19-33	cyclin D1	Homo sapiens	72-81
16510539-6	2006	A significantly (p &lt; 0.01) higher Vmax/Km was observed for homogenates from wild-type UGT1A10139Glu-overexpressing cells against all four BaP metabolites tested (3-OH-BaP, 7-OH-BaP, 9-OH-BaP, and BPD).	Benzo(a)pyrene	141-144	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	89-94
16837912-2	2006	MATERIALS AND METHODS: The conjugates of benzo[a]pyrene, benz[a]anthracene, anthracene, chrysene and pyrene with bovine serum albumin and yeast hexokinase were synthesized.	Benzo(a)pyrene	41-55	hexokinase	Saccharomyces cerevisiae S288C	144-154
16381012-0	2006	Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis.	Benzo(a)pyrene	44-58	mutS homolog 2	Mus musculus	0-4
16805399-6	2006	The total benzo(a)pyrene equivalent (BaPeq) emission factors in the exhaust from PDF, L3.5, L7.5, and L15 were 0.0402, 0.121, 0.219, and 0.548 mg L(-1), respectively.	Benzo(a)pyrene	10-24	immunoglobulin kappa variable 1D-16	Homo sapiens	102-105
16541199-0	2006	Involvement of endogenous nitric oxide in myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury.	Benzo(a)pyrene	67-81	myeloperoxidase	Rattus norvegicus	42-57
16541199-6	2006	A significant augmentation was observed in the nitrite content, activities of superoxide dismutase, MPO and GST and the expressions of iNOS and CYP1A1, however, catalase activity was attenuated in PMNs of benzo(a)pyrene treated rats as compared with their respective controls.	Benzo(a)pyrene	205-219	myeloperoxidase	Rattus norvegicus	100-103
16541199-6	2006	A significant augmentation was observed in the nitrite content, activities of superoxide dismutase, MPO and GST and the expressions of iNOS and CYP1A1, however, catalase activity was attenuated in PMNs of benzo(a)pyrene treated rats as compared with their respective controls.	Benzo(a)pyrene	205-219	hematopoietic prostaglandin D synthase	Rattus norvegicus	108-111
16541199-6	2006	A significant augmentation was observed in the nitrite content, activities of superoxide dismutase, MPO and GST and the expressions of iNOS and CYP1A1, however, catalase activity was attenuated in PMNs of benzo(a)pyrene treated rats as compared with their respective controls.	Benzo(a)pyrene	205-219	nitric oxide synthase 2	Rattus norvegicus	135-139
16541199-6	2006	A significant augmentation was observed in the nitrite content, activities of superoxide dismutase, MPO and GST and the expressions of iNOS and CYP1A1, however, catalase activity was attenuated in PMNs of benzo(a)pyrene treated rats as compared with their respective controls.	Benzo(a)pyrene	205-219	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	144-150
16541199-6	2006	A significant augmentation was observed in the nitrite content, activities of superoxide dismutase, MPO and GST and the expressions of iNOS and CYP1A1, however, catalase activity was attenuated in PMNs of benzo(a)pyrene treated rats as compared with their respective controls.	Benzo(a)pyrene	205-219	catalase	Rattus norvegicus	161-169
16541199-8	2006	CYP1A1 inhibitor alpha-naphthoflavone inhibited the expression of iNOS in PMNs of benzo(a)pyrene treated animals significantly.	Benzo(a)pyrene	82-96	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-6
16541199-8	2006	CYP1A1 inhibitor alpha-naphthoflavone inhibited the expression of iNOS in PMNs of benzo(a)pyrene treated animals significantly.	Benzo(a)pyrene	82-96	nitric oxide synthase 2	Rattus norvegicus	66-70
16198082-0	2006	Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.	Benzo(a)pyrene	143-157	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	29-62
16198082-2	2006	The primary CYPs involved in the metabolism and bioactivation of BaP are CYP1A1 and CYP1B1.	Benzo(a)pyrene	65-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	73-79
16198082-2	2006	The primary CYPs involved in the metabolism and bioactivation of BaP are CYP1A1 and CYP1B1.	Benzo(a)pyrene	65-68	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	84-90
16198082-3	2006	Furthermore, BaP can induce expression of CYP1A1 and CYP1B1 via the aryl hydrocarbon receptor.	Benzo(a)pyrene	13-16	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	42-48
16198082-3	2006	Furthermore, BaP can induce expression of CYP1A1 and CYP1B1 via the aryl hydrocarbon receptor.	Benzo(a)pyrene	13-16	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	53-59
16198082-3	2006	Furthermore, BaP can induce expression of CYP1A1 and CYP1B1 via the aryl hydrocarbon receptor.	Benzo(a)pyrene	13-16	aryl hydrocarbon receptor	Rattus norvegicus	68-93
16198082-4	2006	Induction of CYP1A1 and CYP1B1 by BaP in target (lung) and non-target (liver) tissues was investigated utilizing precision-cut rat liver and lung slices exposed to BaP in vitro.	Benzo(a)pyrene	34-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-19
16198082-4	2006	Induction of CYP1A1 and CYP1B1 by BaP in target (lung) and non-target (liver) tissues was investigated utilizing precision-cut rat liver and lung slices exposed to BaP in vitro.	Benzo(a)pyrene	34-37	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	24-30
16198082-7	2006	In vitro exposure of liver and lung slices to BaP resulted in a concentration-dependent increase in CYP1A1 and CYP1B1 mRNA and protein levels, which correlated directly with the exposure-related increase in BaP-DNA adduct levels observed previously in the tissue slices [Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E., Olson, J.R., 2004.	Benzo(a)pyrene	46-49	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	100-106
16198082-7	2006	In vitro exposure of liver and lung slices to BaP resulted in a concentration-dependent increase in CYP1A1 and CYP1B1 mRNA and protein levels, which correlated directly with the exposure-related increase in BaP-DNA adduct levels observed previously in the tissue slices [Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E., Olson, J.R., 2004.	Benzo(a)pyrene	46-49	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	111-117
16198082-7	2006	In vitro exposure of liver and lung slices to BaP resulted in a concentration-dependent increase in CYP1A1 and CYP1B1 mRNA and protein levels, which correlated directly with the exposure-related increase in BaP-DNA adduct levels observed previously in the tissue slices [Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E., Olson, J.R., 2004.	Benzo(a)pyrene	207-210	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	100-106
16198082-7	2006	In vitro exposure of liver and lung slices to BaP resulted in a concentration-dependent increase in CYP1A1 and CYP1B1 mRNA and protein levels, which correlated directly with the exposure-related increase in BaP-DNA adduct levels observed previously in the tissue slices [Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E., Olson, J.R., 2004.	Benzo(a)pyrene	207-210	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	111-117
16198082-10	2006	Pretreatment of animals in vivo with TCDD produced a marked induction of CYP1A1 and CYP1B1 expression in the tissue slices, which was similar to the levels of CYP1A1 and CYP1B1 mRNA achieved in liver and lung following in vivo treatment with BaP.	Benzo(a)pyrene	242-245	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	73-79
16198082-11	2006	Following in vitro exposure to BaP, the levels of CYP1A1 were greater in the lung than the liver, while following all exposures (in vitro and in vivo), the levels of CYP1B1 mRNA were greater in lung tissue compared to liver.	Benzo(a)pyrene	31-34	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	50-56
16198082-11	2006	Following in vitro exposure to BaP, the levels of CYP1A1 were greater in the lung than the liver, while following all exposures (in vitro and in vivo), the levels of CYP1B1 mRNA were greater in lung tissue compared to liver.	Benzo(a)pyrene	31-34	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	166-172
16198082-12	2006	The higher expression of CYP1A1 and CYP1B1 in the lung was associated with higher levels of BaP-DNA adducts in the lung slices (Harrigan et al.	Benzo(a)pyrene	92-95	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-31
16198082-12	2006	The higher expression of CYP1A1 and CYP1B1 in the lung was associated with higher levels of BaP-DNA adducts in the lung slices (Harrigan et al.	Benzo(a)pyrene	92-95	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	36-42
16307768-10	2006	Although TNFalpha and CYP1B1 are implicated as essential mediators of hypocellularity, the similar induction of TNFalpha mRNA and CYP1B1 mRNA in the BM by BP and DMBA suggests that they are not limiting factors in mediating the different effects of these PAHs.	Benzo(a)pyrene	155-157	tumor necrosis factor	Mus musculus	112-120
16307768-10	2006	Although TNFalpha and CYP1B1 are implicated as essential mediators of hypocellularity, the similar induction of TNFalpha mRNA and CYP1B1 mRNA in the BM by BP and DMBA suggests that they are not limiting factors in mediating the different effects of these PAHs.	Benzo(a)pyrene	155-157	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	130-136
16647797-0	2006	Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer.	Benzo(a)pyrene	10-24	ATP binding cassette subfamily B member 1	Homo sapiens	28-42
16647797-1	2006	The main exposure pathway of benzo[a]pyrene (Bap) for humans is considered to be via the daily diet.	Benzo(a)pyrene	29-43	prohibitin 2	Homo sapiens	45-48
16839212-1	2006	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands.	Benzo(a)pyrene	159-173	aryl hydrocarbon receptor	Rattus norvegicus	4-29
16699726-0	2006	Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 3	Homo sapiens	57-61
16699726-0	2006	Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts.	Benzo(a)pyrene	0-14	cyclin D1	Homo sapiens	62-71
16699726-0	2006	Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 1	Homo sapiens	120-123
16226778-8	2006	G. biloba extract also reduced benzo[a]pyrene hydroxylation, and the effect was greater with CYP1B1 than with CYP1A1 as the catalyst.	Benzo(a)pyrene	31-45	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	93-99
16226778-8	2006	G. biloba extract also reduced benzo[a]pyrene hydroxylation, and the effect was greater with CYP1B1 than with CYP1A1 as the catalyst.	Benzo(a)pyrene	31-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	110-116
16612255-10	2006	CONCLUSIONS: These data demonstrate that CYP3A5 polymorphisms are associated with ambulatory BP, CYP3A5*1 carriers showing a higher age- and sodium- related increase in ABP than non-carriers.	Benzo(a)pyrene	93-95	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	41-47
16612255-10	2006	CONCLUSIONS: These data demonstrate that CYP3A5 polymorphisms are associated with ambulatory BP, CYP3A5*1 carriers showing a higher age- and sodium- related increase in ABP than non-carriers.	Benzo(a)pyrene	93-95	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	97-103
16773535-7	2006	mRNA expression of CYP1A1 or CYP1A2 induced by the promutagen benzo[a]pyrene was significantly down-regulated by EGCG but not by GTE.	Benzo(a)pyrene	62-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-25
16773535-7	2006	mRNA expression of CYP1A1 or CYP1A2 induced by the promutagen benzo[a]pyrene was significantly down-regulated by EGCG but not by GTE.	Benzo(a)pyrene	62-76	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	29-35
16737584-1	2006	OBJECTIVE: To explore the relationship between genetic polymorphisms of CYP-1A1 and CYP2D6 and risks of chronic benzene poisoning (BP).	Benzo(a)pyrene	131-133	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-79
16737584-1	2006	OBJECTIVE: To explore the relationship between genetic polymorphisms of CYP-1A1 and CYP2D6 and risks of chronic benzene poisoning (BP).	Benzo(a)pyrene	131-133	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	84-90
16737584-8	2006	In no-smoking population, there was a 1.23 times (95% CI: 1.04 approximately 1.47, P = 0.01) increased risk of BP for subjects carrying CYP2D6 c.188 C/C or C/T genotypes compared with those carrying T/T genotype.	Benzo(a)pyrene	111-113	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	136-142
16256281-8	2006	Cyp1a2 knockout reduced skin BAP adduct levels 50% and AHR knockout reduced skin BAP adduct levels by 90%.	Benzo(a)pyrene	29-32	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	0-6
16256281-8	2006	Cyp1a2 knockout reduced skin BAP adduct levels 50% and AHR knockout reduced skin BAP adduct levels by 90%.	Benzo(a)pyrene	81-84	aryl-hydrocarbon receptor	Mus musculus	55-58
16839212-1	2006	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands.	Benzo(a)pyrene	159-173	aryl hydrocarbon receptor	Rattus norvegicus	31-34
16611024-1	2006	Cytochrome P450 (CYP) 1A1 attracts attention mainly because of its role in production of carcinogenic reactive metabolites from polycyclic aromatic hydrocarbons such as benzo[a]pyrene, but recent developments indicate its apparent role in cell cycle progression.	Benzo(a)pyrene	169-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-25
16377763-0	2006	Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	50-56
16377763-0	2006	Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.	Benzo(a)pyrene	5-19	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	84-90
16377763-1	2006	CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis.	Benzo(a)pyrene	97-111	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	0-6
16377763-1	2006	CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis.	Benzo(a)pyrene	97-111	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	11-17
16377763-4	2006	After administration of oral benzo[a]pyrene (125 mg/kg/day) for 18 days, Cyp1a1-/- mice showed marked wasting, immunosuppression, and bone marrow hypocellularity, whereas the other five genotypes did not.	Benzo(a)pyrene	29-43	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	73-79
16377763-5	2006	After 5 days of feeding, steady-state blood levels of benzo[a]pyrene were approximately 25 and approximately 75 times higher in Cyp1a1-/- and Cyp1a1/1b1-/- mice, respectively, than in wild-type mice.	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	128-134
16377763-5	2006	After 5 days of feeding, steady-state blood levels of benzo[a]pyrene were approximately 25 and approximately 75 times higher in Cyp1a1-/- and Cyp1a1/1b1-/- mice, respectively, than in wild-type mice.	Benzo(a)pyrene	54-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	142-148
16377763-6	2006	Benzo[a]pyrene-DNA adduct levels were highest in liver, spleen, and marrow of Cyp1a1-/- and Cyp1a1/1b1-/- mice.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	78-84
16377763-6	2006	Benzo[a]pyrene-DNA adduct levels were highest in liver, spleen, and marrow of Cyp1a1-/- and Cyp1a1/1b1-/- mice.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	92-98
16377763-8	2006	Thus, a balance between tissue-specific expression of the CYP1A1 and CYP1B1 enzymes governs sensitivity of benzo[a]pyrene toxicity and, possibly, carcinogenicity.	Benzo(a)pyrene	107-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	58-64
16377763-8	2006	Thus, a balance between tissue-specific expression of the CYP1A1 and CYP1B1 enzymes governs sensitivity of benzo[a]pyrene toxicity and, possibly, carcinogenicity.	Benzo(a)pyrene	107-121	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	69-75
16185837-9	2006	Further, RFFO extract caused a dose dependent increase (2.1-3.5-fold) in aryl hydrocarbon hydroxylase (AHH) activity at 48 h. Induction of EROD and AHH activity in Hep G2 cells was found to be relatively more following BP or chrysene treatment as compared to RFFO extract.	Benzo(a)pyrene	219-221	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	73-101
16185837-9	2006	Further, RFFO extract caused a dose dependent increase (2.1-3.5-fold) in aryl hydrocarbon hydroxylase (AHH) activity at 48 h. Induction of EROD and AHH activity in Hep G2 cells was found to be relatively more following BP or chrysene treatment as compared to RFFO extract.	Benzo(a)pyrene	219-221	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	103-106
16426572-6	2006	Furthermore, formation of total benzo(a)pyrene (BaP)-DNA adducts was not altered following BaP exposure in TCDD-treated primary hepatocytes, whereas significantly elevated, in a CYP1A1-dependent manner, in the treated HepG2 cells.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	178-184
16426572-6	2006	Furthermore, formation of total benzo(a)pyrene (BaP)-DNA adducts was not altered following BaP exposure in TCDD-treated primary hepatocytes, whereas significantly elevated, in a CYP1A1-dependent manner, in the treated HepG2 cells.	Benzo(a)pyrene	48-51	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	178-184
16380375-3	2006	The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand.	Benzo(a)pyrene	95-98	WRN RecQ like helicase	Homo sapiens	29-32
16380375-3	2006	The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand.	Benzo(a)pyrene	95-98	helicase for meiosis 1	Homo sapiens	33-41
16380375-5	2006	In contrast, helicase activity is only mildly affected by intercalating BaP DE-dA adducts that locally perturb DNA double helical structure.	Benzo(a)pyrene	72-75	helicase for meiosis 1	Homo sapiens	13-21
16480812-1	2006	Aryl hydrocarbon receptor (AhR) ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or benzo(a)pyrene interfere with hormonal regulatory pathways, leading to endocrine disruption.	Benzo(a)pyrene	94-108	aryl hydrocarbon receptor	Homo sapiens	0-25
16480812-1	2006	Aryl hydrocarbon receptor (AhR) ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or benzo(a)pyrene interfere with hormonal regulatory pathways, leading to endocrine disruption.	Benzo(a)pyrene	94-108	aryl hydrocarbon receptor	Homo sapiens	27-30
16244358-1	2006	DNA damage caused by benzo[a]pyrene (B[a]P) or other polynuclear hydrocarbons (PAHs) induce p53 protein as a protective measure to eliminate the possibility of mutagenic fixation of the DNA damage.	Benzo(a)pyrene	21-35	transformation related protein 53, pseudogene	Mus musculus	92-95
16244358-1	2006	DNA damage caused by benzo[a]pyrene (B[a]P) or other polynuclear hydrocarbons (PAHs) induce p53 protein as a protective measure to eliminate the possibility of mutagenic fixation of the DNA damage.	Benzo(a)pyrene	37-42	transformation related protein 53, pseudogene	Mus musculus	92-95
16280210-0	2006	Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells.	Benzo(a)pyrene	39-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	62-68
16280210-3	2006	To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts.	Benzo(a)pyrene	101-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	189-208
16280210-3	2006	To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts.	Benzo(a)pyrene	101-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	210-216
16280210-3	2006	To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts.	Benzo(a)pyrene	257-260	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	189-208
16280210-3	2006	To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts.	Benzo(a)pyrene	257-260	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	210-216
16280210-3	2006	To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts.	Benzo(a)pyrene	257-260	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	189-208
16280210-3	2006	To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts.	Benzo(a)pyrene	257-260	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	210-216
16280210-4	2006	Northern blot analysis presented that 1-NP attenuated BaP-induced CYP1A1 mRNA expression by 30.4-39.6% (p &lt; 0.05).	Benzo(a)pyrene	54-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-72
16280210-5	2006	Western blot analysis revealed that the co-treatment with BaP and 1-NP resulted in a significant inhibition of BaP-induced CYP1A1 protein expression (70.7-88.2%, p &lt; 0.05).	Benzo(a)pyrene	58-61	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
16280210-5	2006	Western blot analysis revealed that the co-treatment with BaP and 1-NP resulted in a significant inhibition of BaP-induced CYP1A1 protein expression (70.7-88.2%, p &lt; 0.05).	Benzo(a)pyrene	111-114	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
16280210-9	2006	In addition, the relative levels of reactive oxygen species (ROS) were elevated in HepG2 cells co-treated with BaP and 1-NP, indicating that the decrease of CYP1A1 protein level was probably attributed to the production of ROS generated by binary mixture.	Benzo(a)pyrene	111-114	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	157-163
16280210-10	2006	Taken together, these findings suggested that the transcriptional suppression and posttranslational mechanism may be involved in loss of CYP1A1 protein, causing the decrease of BaP-DNA adduct levels in the presence of binary mixtures of 1-NP and BaP.	Benzo(a)pyrene	177-180	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	137-143
16280210-10	2006	Taken together, these findings suggested that the transcriptional suppression and posttranslational mechanism may be involved in loss of CYP1A1 protein, causing the decrease of BaP-DNA adduct levels in the presence of binary mixtures of 1-NP and BaP.	Benzo(a)pyrene	246-249	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	137-143
16758952-0	2006	[Benzo(a)pyrene induced changes of cyclin D1, CDK4 and E2F-1/4 expression in human embryo lung fibroblasts].	Benzo(a)pyrene	1-15	cyclin dependent kinase 4	Homo sapiens	46-50
16758952-0	2006	[Benzo(a)pyrene induced changes of cyclin D1, CDK4 and E2F-1/4 expression in human embryo lung fibroblasts].	Benzo(a)pyrene	1-15	cyclin D1	Homo sapiens	35-44
16758952-0	2006	[Benzo(a)pyrene induced changes of cyclin D1, CDK4 and E2F-1/4 expression in human embryo lung fibroblasts].	Benzo(a)pyrene	1-15	E2F transcription factor 1	Homo sapiens	55-62
16758952-1	2006	OBJECTIVE: To establish Benzo (a) pyrene-treated human embryo lung fibroblasts (HELF), which were provided with some characteristics of transformed cells (T-HELF), and observe the changes of cyclin D, CDK4 and E2F-1/4 expression in T-HELF cells.	Benzo(a)pyrene	24-40	cyclin dependent kinase 4	Homo sapiens	201-205
16758952-1	2006	OBJECTIVE: To establish Benzo (a) pyrene-treated human embryo lung fibroblasts (HELF), which were provided with some characteristics of transformed cells (T-HELF), and observe the changes of cyclin D, CDK4 and E2F-1/4 expression in T-HELF cells.	Benzo(a)pyrene	24-40	E2F transcription factor 1	Homo sapiens	210-215
16600130-6	2006	Compared with individuals carrying genotypes of hOGG1c.326Cys/Cy and hMYHc.335 is/His at the same time, there was 0.33 times (OR(adj) = 0.33, 95% CI = 0.15-0.72, P = 0.01) risks of BP for these with genotypes of hOGG1c.326Ser/Cys + Ser/Ser and hMYHc.335His/Gln + Gln/Gln simultaneously.	Benzo(a)pyrene	181-183	myosin heavy chain 6	Homo sapiens	69-74
16377763-0	2006	Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.	Benzo(a)pyrene	5-19	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	23-27
16640900-1	2006	OBJECTIVE: To study the role of E2F1/4 pathway in vitamin C reversing benzo (a) pyrene [B (a) P]-induced changes of cell cycle in human embryo lung fibroblasts (HELF) and the relationship between E2F1 and cyclin D1/CDK4.	Benzo(a)pyrene	70-86	E2F transcription factor 1	Homo sapiens	32-36
16640900-12	2006	CONCLUSION: Vitamin C might reserve the B (a) P-induced changes of cell cycle via intracellular signaling pathway of cyclin D1-CDK4/E2F-1/4.	Benzo(a)pyrene	40-47	cyclin D1	Homo sapiens	117-126
16640900-12	2006	CONCLUSION: Vitamin C might reserve the B (a) P-induced changes of cell cycle via intracellular signaling pathway of cyclin D1-CDK4/E2F-1/4.	Benzo(a)pyrene	40-47	cyclin-dependent kinase 4 S homeolog	Xenopus laevis	127-131
16640900-12	2006	CONCLUSION: Vitamin C might reserve the B (a) P-induced changes of cell cycle via intracellular signaling pathway of cyclin D1-CDK4/E2F-1/4.	Benzo(a)pyrene	40-47	E2F transcription factor 1 L homeolog	Xenopus laevis	132-139
16640902-0	2006	[Expression deficiency of JWA enhanced DNA damage and delayed DNA repair in HeLa cells induced by benzo (a) pyrene exposure].	Benzo(a)pyrene	98-114	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	26-29
16640902-1	2006	OBJECTIVE: To investigate the role of JWA gene in benzo (a) pyrene [B (a) P] induced DNA damage and repair effects in HeLa cells.	Benzo(a)pyrene	50-66	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	38-41
16640902-1	2006	OBJECTIVE: To investigate the role of JWA gene in benzo (a) pyrene [B (a) P] induced DNA damage and repair effects in HeLa cells.	Benzo(a)pyrene	68-75	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	38-41
16406622-4	2006	Our results showed that after treatment with B(a)P, the expression of cyclin D1 and E2F-1 were both increased significantly in HELF.	Benzo(a)pyrene	45-50	cyclin D1	Homo sapiens	70-79
16406622-4	2006	Our results showed that after treatment with B(a)P, the expression of cyclin D1 and E2F-1 were both increased significantly in HELF.	Benzo(a)pyrene	45-50	E2F transcription factor 1	Homo sapiens	84-89
16406622-10	2006	It was suggested that ATRA could block B(a)P-induced cell cycle promotion partly through the cyclin D1/E2F-1 pathway in HELF.	Benzo(a)pyrene	39-44	cyclin D1	Homo sapiens	93-102
16406622-10	2006	It was suggested that ATRA could block B(a)P-induced cell cycle promotion partly through the cyclin D1/E2F-1 pathway in HELF.	Benzo(a)pyrene	39-44	E2F transcription factor 1	Homo sapiens	103-108
16600130-6	2006	Compared with individuals carrying genotypes of hOGG1c.326Cys/Cy and hMYHc.335 is/His at the same time, there was 0.33 times (OR(adj) = 0.33, 95% CI = 0.15-0.72, P = 0.01) risks of BP for these with genotypes of hOGG1c.326Ser/Cys + Ser/Ser and hMYHc.335His/Gln + Gln/Gln simultaneously.	Benzo(a)pyrene	181-183	myosin heavy chain 6	Homo sapiens	244-249
16371432-8	2006	Aortae of mice treated with Ang II antagonism had fewer elastin breaks together with less immunostaining for the powerful elastolytic enzyme cathepsin S. None of these benefits was observed in the hydralazine-treated mice despite equivalent reduction in BP.	Benzo(a)pyrene	254-256	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	28-34
16519321-7	2006	In Drosophila exposed to benzo[a]pyrene or to ambient air polluted by higher or lower PAH concentrations, P-gp expression was clearly showed a dose-dependent increase response.	Benzo(a)pyrene	25-39	Multi drug resistance 65	Drosophila melanogaster	106-110
16392842-1	2006	The molecules benzo[a]pyrene (BaP) and 1-, 3-, and 6-nitrobenzo[a]pyrene (1-NBaP, 3-NBaP, 6-NBaP) are currently of significant interest due to their presence in respirable combustion exhaust particulates and their mutagenic and carcinogenic properties.	Benzo(a)pyrene	14-28	prohibitin 2	Homo sapiens	30-33
16600106-0	2006	[cyclin D1/E2F pathways involved in cell cycle changes of human embryo lung fibroblasts induced by benzo(a)pyrene].	Benzo(a)pyrene	99-113	cyclin D1	Mus musculus	1-10
16600107-1	2006	OBJECTIVE: To study the role of mitogen activated protein kinase (MAPK)/activator protein-1 (AP-1) pathway in benzo(a)pyrene (B(a)P)-induced changes of cell cycle in human embryo lung fibroblasts (HELF).	Benzo(a)pyrene	110-124	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-91
16600107-1	2006	OBJECTIVE: To study the role of mitogen activated protein kinase (MAPK)/activator protein-1 (AP-1) pathway in benzo(a)pyrene (B(a)P)-induced changes of cell cycle in human embryo lung fibroblasts (HELF).	Benzo(a)pyrene	126-131	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-91
16600107-11	2006	CONCLUSION: ERK and JNK, but not p38, mediated benzo(a)pyrene-induced cell cycle changes by AP-1 transactivation in HELF.	Benzo(a)pyrene	47-61	mitogen-activated protein kinase 1	Homo sapiens	12-15
16600107-11	2006	CONCLUSION: ERK and JNK, but not p38, mediated benzo(a)pyrene-induced cell cycle changes by AP-1 transactivation in HELF.	Benzo(a)pyrene	47-61	mitogen-activated protein kinase 8	Homo sapiens	20-23
17083267-6	2006	The ASCOT-BPLA trial underlines the cardiovascular benefit of ACE inhibitors, specifically perindopril, beyond that provided by BP reduction, and potentially reflects a mechanistic feature of the ACE inhibitors.	Benzo(a)pyrene	10-12	angiotensin I converting enzyme	Homo sapiens	62-65
17083267-6	2006	The ASCOT-BPLA trial underlines the cardiovascular benefit of ACE inhibitors, specifically perindopril, beyond that provided by BP reduction, and potentially reflects a mechanistic feature of the ACE inhibitors.	Benzo(a)pyrene	10-12	angiotensin I converting enzyme	Homo sapiens	196-199
16844322-1	2006	BACKGROUND: Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines.	Benzo(a)pyrene	152-166	myeloperoxidase	Homo sapiens	12-27
16101586-5	2006	Transfection assays in cell cultures with fragments from BP driving the expression of luciferase confirmed that only in the presence of the SMAD consensus site is Msx1 expression activated.	Benzo(a)pyrene	57-59	SMAD family member 1	Mus musculus	140-144
16101586-5	2006	Transfection assays in cell cultures with fragments from BP driving the expression of luciferase confirmed that only in the presence of the SMAD consensus site is Msx1 expression activated.	Benzo(a)pyrene	57-59	msh homeobox 1	Mus musculus	163-167
16844322-1	2006	BACKGROUND: Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines.	Benzo(a)pyrene	152-166	myeloperoxidase	Homo sapiens	29-32
17145695-3	2006	Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003).	Benzo(a)pyrene	195-209	aryl-hydrocarbon receptor	Mus musculus	160-185
17145695-3	2006	Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003).	Benzo(a)pyrene	195-209	aryl-hydrocarbon receptor	Mus musculus	187-190
17145695-3	2006	Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003).	Benzo(a)pyrene	211-214	aryl-hydrocarbon receptor	Mus musculus	160-185
15996733-7	2006	A good correlation existed between the benzo[a]pyrene level and the total PAH concentration (r=0.97), making benzo[a]pyrene a potential molecular marker for PAH pollution.	Benzo(a)pyrene	39-53	phenylalanine hydroxylase	Homo sapiens	74-77
17145695-4	2006	Nephron formation is inhibited by BaP, a response that involves inhibition of metanephric cell differentiation and shifts in the relative abundance of Wt1 splice variants.	Benzo(a)pyrene	34-37	WT1 transcription factor	Mus musculus	151-154
15996733-7	2006	A good correlation existed between the benzo[a]pyrene level and the total PAH concentration (r=0.97), making benzo[a]pyrene a potential molecular marker for PAH pollution.	Benzo(a)pyrene	39-53	phenylalanine hydroxylase	Homo sapiens	157-160
15996733-7	2006	A good correlation existed between the benzo[a]pyrene level and the total PAH concentration (r=0.97), making benzo[a]pyrene a potential molecular marker for PAH pollution.	Benzo(a)pyrene	109-123	phenylalanine hydroxylase	Homo sapiens	74-77
15996733-7	2006	A good correlation existed between the benzo[a]pyrene level and the total PAH concentration (r=0.97), making benzo[a]pyrene a potential molecular marker for PAH pollution.	Benzo(a)pyrene	109-123	phenylalanine hydroxylase	Homo sapiens	157-160
17145695-5	2006	A systems biology paradigm that combined approaches from genomics, transcriptomics, and bioinformatics revealed that the global response of murine metanephric cultures to BaP involves downregulation of Ahr and disruption of downstream targets of Wt1.	Benzo(a)pyrene	171-174	aryl-hydrocarbon receptor	Mus musculus	202-205
17145695-5	2006	A systems biology paradigm that combined approaches from genomics, transcriptomics, and bioinformatics revealed that the global response of murine metanephric cultures to BaP involves downregulation of Ahr and disruption of downstream targets of Wt1.	Benzo(a)pyrene	171-174	WT1 transcription factor	Mus musculus	246-249
18958682-7	2006	Similarly, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), which are AhR ligands, induced remarkably similar changes in gene expression compared to DEP extracts.	Benzo(a)pyrene	58-72	aryl-hydrocarbon receptor	Mus musculus	92-95
16337890-6	2006	Furthermore, the combination of free fatty acid and iron is highly mutagenic, inducing almost as many selectable mutations in the gene for hypoxanthine/guanine phosphoribosyl transferase as does benzo[a]pyrenediolepoxide, a class I carcinogen generated from benzo[a]pyrene present in cigarette smoke.	Benzo(a)pyrene	195-209	hypoxanthine-guanine phosphoribosyltransferase	Nicotiana tabacum	139-186
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	67-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-42
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	67-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	67-81	aryl hydrocarbon receptor	Homo sapiens	176-201
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	67-81	aryl hydrocarbon receptor	Homo sapiens	203-206
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	83-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-42
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	83-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	83-88	aryl hydrocarbon receptor	Homo sapiens	176-201
16191477-3	2006	Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	83-88	aryl hydrocarbon receptor	Homo sapiens	203-206
16497109-13	2006	A different basal BP response, but equally attenuated hypotension to Ach and BK, was detected after the inhibition of two selected hyperpolarizing pathways.	Benzo(a)pyrene	18-20	kininogen 1	Homo sapiens	77-79
16237193-1	2006	Both benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands of aryl hydrocarbon receptors (AhR).	Benzo(a)pyrene	5-19	aryl hydrocarbon receptor	Homo sapiens	95-121
16237193-1	2006	Both benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands of aryl hydrocarbon receptors (AhR).	Benzo(a)pyrene	5-19	aryl hydrocarbon receptor	Homo sapiens	123-126
16237193-1	2006	Both benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands of aryl hydrocarbon receptors (AhR).	Benzo(a)pyrene	21-24	aryl hydrocarbon receptor	Homo sapiens	95-121
16237193-1	2006	Both benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands of aryl hydrocarbon receptors (AhR).	Benzo(a)pyrene	21-24	aryl hydrocarbon receptor	Homo sapiens	123-126
16237193-4	2006	Here we explore the hypothesis that CCSP-positive Clara cells are highly responsive to AhR ligands and are the primary cell type involved in BaP- and TCDD-induced toxicities.	Benzo(a)pyrene	141-144	secretoglobin family 1A member 1	Homo sapiens	36-40
16237193-8	2006	BaP- and TCDD-induced mRNA and protein levels of CYP1A1 and CYP1B1 levels were significantly elevated in CCSP-positive cell cultures.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-55
16237193-8	2006	BaP- and TCDD-induced mRNA and protein levels of CYP1A1 and CYP1B1 levels were significantly elevated in CCSP-positive cell cultures.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	60-66
16237193-8	2006	BaP- and TCDD-induced mRNA and protein levels of CYP1A1 and CYP1B1 levels were significantly elevated in CCSP-positive cell cultures.	Benzo(a)pyrene	0-3	secretoglobin family 1A member 1	Homo sapiens	105-109
16237193-10	2006	When rat lung slice cultures were treated with BaP or TCDD for 24 h, CYP1A1 and CYP1B1 proteins were strongly induced in Clara cells.	Benzo(a)pyrene	47-50	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	69-75
16237193-10	2006	When rat lung slice cultures were treated with BaP or TCDD for 24 h, CYP1A1 and CYP1B1 proteins were strongly induced in Clara cells.	Benzo(a)pyrene	47-50	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	80-86
16297369-0	2005	p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation.	Benzo(a)pyrene	25-39	mitogen-activated protein kinase 14	Homo sapiens	0-3
16297369-0	2005	p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation.	Benzo(a)pyrene	25-39	tumor protein p53	Homo sapiens	84-87
16297369-3	2005	Pharmacological inhibition of p38 kinase markedly inhibited the BaP-induced cytotoxicity, which was proven as apoptosis characterized by an increase in sub-G(0)/G(1) fraction of DNA content, ladder-pattern fragmentation of genomic DNA, and catalytic activation of caspase-3 with PARP cleavage.	Benzo(a)pyrene	64-67	mitogen-activated protein kinase 14	Homo sapiens	30-33
16297369-3	2005	Pharmacological inhibition of p38 kinase markedly inhibited the BaP-induced cytotoxicity, which was proven as apoptosis characterized by an increase in sub-G(0)/G(1) fraction of DNA content, ladder-pattern fragmentation of genomic DNA, and catalytic activation of caspase-3 with PARP cleavage.	Benzo(a)pyrene	64-67	caspase 3	Homo sapiens	264-273
16297369-3	2005	Pharmacological inhibition of p38 kinase markedly inhibited the BaP-induced cytotoxicity, which was proven as apoptosis characterized by an increase in sub-G(0)/G(1) fraction of DNA content, ladder-pattern fragmentation of genomic DNA, and catalytic activation of caspase-3 with PARP cleavage.	Benzo(a)pyrene	64-67	poly(ADP-ribose) polymerase 1	Homo sapiens	279-283
16297369-5	2005	Also, pharmacological inhibition of p38 markedly inhibited the phosphorylation, accumulated expression, and transactivation activity of p53 in BaP-treated cells.	Benzo(a)pyrene	143-146	mitogen-activated protein kinase 14	Homo sapiens	36-39
16297369-5	2005	Also, pharmacological inhibition of p38 markedly inhibited the phosphorylation, accumulated expression, and transactivation activity of p53 in BaP-treated cells.	Benzo(a)pyrene	143-146	tumor protein p53	Homo sapiens	136-139
16297369-7	2005	Furthermore, p53 mediated apoptotic activity in BaP-treated cells was inhibited by p38 kinase inhibitor.	Benzo(a)pyrene	48-51	tumor protein p53	Homo sapiens	13-16
16297369-7	2005	Furthermore, p53 mediated apoptotic activity in BaP-treated cells was inhibited by p38 kinase inhibitor.	Benzo(a)pyrene	48-51	mitogen-activated protein kinase 14	Homo sapiens	83-86
16297369-8	2005	The current data collectively indicate that BaP induces apoptosis of Hepa1c1c7 cells via activation of p53-related signaling, which was, in part, regulated by p38 kinase.	Benzo(a)pyrene	44-47	transformation related protein 53, pseudogene	Mus musculus	103-106
16297369-8	2005	The current data collectively indicate that BaP induces apoptosis of Hepa1c1c7 cells via activation of p53-related signaling, which was, in part, regulated by p38 kinase.	Benzo(a)pyrene	44-47	mitogen-activated protein kinase 14	Homo sapiens	159-162
16099480-2	2005	The protective effects were attributed to induction of glutathione-S-transferases (GSTs) and aim of the present human study was to find out if coffee causes induction of GSTs and protects against DNA-damage caused by (+/-)-anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), the DNA-reactive metabolite of benzo(a)pyrene.	Benzo(a)pyrene	302-316	glutathione S-transferase pi 1	Homo sapiens	170-174
16041517-0	2005	Gaseous nitrogen oxide repressed benzo[a]pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals.	Benzo(a)pyrene	33-47	mitogen-activated protein kinase 8	Homo sapiens	108-112
16311918-13	2005	We suggest that some of the long-term advantages of ACE inhibitor use - beyond mere BP lowering - might be due to a PPAR mediated effect.	Benzo(a)pyrene	84-86	angiotensin I converting enzyme	Rattus norvegicus	52-55
16218752-1	2005	Cytochrome P450 1A1 oxidizes a diverse range of substrates, including the procarcinogenic xenobiotic benzo[a]pyrene (B[a]P) and endogenous fatty acid precursors of prostaglandins, such as arachidonic acid (AA) and eicosapentaenoic acid (EA).	Benzo(a)pyrene	101-115	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
16218752-1	2005	Cytochrome P450 1A1 oxidizes a diverse range of substrates, including the procarcinogenic xenobiotic benzo[a]pyrene (B[a]P) and endogenous fatty acid precursors of prostaglandins, such as arachidonic acid (AA) and eicosapentaenoic acid (EA).	Benzo(a)pyrene	117-122	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19
16311918-13	2005	We suggest that some of the long-term advantages of ACE inhibitor use - beyond mere BP lowering - might be due to a PPAR mediated effect.	Benzo(a)pyrene	84-86	peroxisome proliferator activated receptor alpha	Rattus norvegicus	116-120
16207632-0	2005	Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells.	Benzo(a)pyrene	36-50	estrogen receptor 1	Homo sapiens	10-27
16162842-5	2005	Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP.	Benzo(a)pyrene	100-102	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
16162842-5	2005	Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP.	Benzo(a)pyrene	100-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
16162842-5	2005	Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP.	Benzo(a)pyrene	146-148	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
16162842-5	2005	Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP.	Benzo(a)pyrene	146-148	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
16256111-0	2005	Co-exposure to benzo[a]pyrene and UVA induces phosphorylation of histone H2AX.	Benzo(a)pyrene	15-29	H2A.X variant histone	Homo sapiens	73-77
16256111-2	2005	We have previously shown that co-exposure to benzo[a]pyrene (BaP), a wide-spread environmental carcinogen, and ultraviolet A (UVA), a major component of solar UV radiation, induced DSBs in mammalian cells.	Benzo(a)pyrene	45-59	prohibitin 2	Homo sapiens	61-64
16207632-0	2005	Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells.	Benzo(a)pyrene	36-50	estrogen receptor 1	Homo sapiens	29-31
16207632-1	2005	To investigate the role of estrogen and estrogen receptor (ER) during benzo[a]pyrene (BaP) carcinogenesis, BaP-DNA adduct formation, and DNA synthesis were examined in ER-positive, MCF-7, and ER-negative, MDA-MB-231, human breast cancer cell lines.	Benzo(a)pyrene	70-84	estrogen receptor 1	Homo sapiens	59-61
16078292-4	2005	The contribution of the lifetime-dependent term on k(TET) was 27, 60, and 86% for CCl4, Bz, and DCB as the Q of BP(T(n)), respectively, indicating that the TET from BP(T(n)) to Q is influenced not only by tau(T(n)), but also by the size of Q.	Benzo(a)pyrene	165-167	C-C motif chemokine ligand 4	Homo sapiens	82-86
16126119-13	2005	These findings indicate firstly that RSG is able to induce a reduction of BP and secondly the amelioration of insulin sensitivity is associated with the reduction of BP.	Benzo(a)pyrene	166-168	insulin	Homo sapiens	110-117
16078292-4	2005	The contribution of the lifetime-dependent term on k(TET) was 27, 60, and 86% for CCl4, Bz, and DCB as the Q of BP(T(n)), respectively, indicating that the TET from BP(T(n)) to Q is influenced not only by tau(T(n)), but also by the size of Q.	Benzo(a)pyrene	112-114	C-C motif chemokine ligand 4	Homo sapiens	82-86
16358226-9	2005	Proper management of both BP and UP until sCr has reached PNR is essential to arrest the progression to ESRD in IgAN.	Benzo(a)pyrene	26-28	IGAN1	Homo sapiens	112-116
15905203-0	2005	Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.	Benzo(a)pyrene	36-50	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	26-32
15905203-1	2005	The roles of CYP1A1 and 1B1 in tobacco smoke carcinogen, e.g. benzo[a]pyrene (BaP), induced DNA binding and their inhibition by the dietary polyphenol 5,7-dimethoxyflavone (DMF), compared with 3",4"-dimethoxyflavone (3",4"-DMF) and resveratrol, were investigated in the human oral epithelial squamous cell carcinoma (SCC)-9 cells.	Benzo(a)pyrene	62-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
15905203-1	2005	The roles of CYP1A1 and 1B1 in tobacco smoke carcinogen, e.g. benzo[a]pyrene (BaP), induced DNA binding and their inhibition by the dietary polyphenol 5,7-dimethoxyflavone (DMF), compared with 3",4"-dimethoxyflavone (3",4"-DMF) and resveratrol, were investigated in the human oral epithelial squamous cell carcinoma (SCC)-9 cells.	Benzo(a)pyrene	78-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
15905203-2	2005	A low concentration of BaP (1 microM) dramatically induced BaP-DNA adduct formation (approximately 40-fold) in a time-dependent manner, while it only increased CYP1A1/1B1 activities, as measured by ethoxyresorufin O-deethylation, approximately 3-fold.	Benzo(a)pyrene	23-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-170
15905203-3	2005	Furthermore, BaP induced both CYP1B1 and CYP1A1 mRNA and protein expression, as determined by the branched DNA assay and western blot analysis, but with considerably higher levels of CYP1B1.	Benzo(a)pyrene	13-16	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	30-36
15905203-3	2005	Furthermore, BaP induced both CYP1B1 and CYP1A1 mRNA and protein expression, as determined by the branched DNA assay and western blot analysis, but with considerably higher levels of CYP1B1.	Benzo(a)pyrene	13-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-47
15905203-3	2005	Furthermore, BaP induced both CYP1B1 and CYP1A1 mRNA and protein expression, as determined by the branched DNA assay and western blot analysis, but with considerably higher levels of CYP1B1.	Benzo(a)pyrene	13-16	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	183-189
15917307-0	2005	Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.	Benzo(a)pyrene	41-55	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	18-22
15917307-2	2005	The present study reveals that BCRP is involved in the transport of phase-2 metabolites of the carcinogen benzo[a]pyrene (BP) in the human intestinal cell line Caco-2.	Benzo(a)pyrene	106-120	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	31-35
15917307-2	2005	The present study reveals that BCRP is involved in the transport of phase-2 metabolites of the carcinogen benzo[a]pyrene (BP) in the human intestinal cell line Caco-2.	Benzo(a)pyrene	122-124	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	31-35
15917307-5	2005	Furthermore, the expression of BCRP is most likely aryl hydrocarbon receptor (AhR) dependent, as treatment of Caco-2 cells with known AhR agonists including 2,3,7,8-tetrachlorodibenzo-p-dioxin, BP, indolo[3,2-b]carbazole and benzo[k]fluoranthene increased both mRNA and protein levels of BCRP.	Benzo(a)pyrene	194-196	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	31-35
15917307-5	2005	Furthermore, the expression of BCRP is most likely aryl hydrocarbon receptor (AhR) dependent, as treatment of Caco-2 cells with known AhR agonists including 2,3,7,8-tetrachlorodibenzo-p-dioxin, BP, indolo[3,2-b]carbazole and benzo[k]fluoranthene increased both mRNA and protein levels of BCRP.	Benzo(a)pyrene	194-196	aryl hydrocarbon receptor	Homo sapiens	51-76
16245837-3	2005	A profile comparison of the PAH mixture--using benzo[a]pyrene (B[a]P) relative abundance ratios (PAH/B[a]P)--for the cascade impactor filters indicated the formation of a sampling artifact.	Benzo(a)pyrene	47-61	phenylalanine hydroxylase	Homo sapiens	28-31
16093449-1	2005	Bradykinin (BK) is one of the most important peptides regulating vascular tone, water, and ionic balance in the body, playing a key role in controlling BP.	Benzo(a)pyrene	152-154	kininogen 1	Homo sapiens	0-10
16093449-1	2005	Bradykinin (BK) is one of the most important peptides regulating vascular tone, water, and ionic balance in the body, playing a key role in controlling BP.	Benzo(a)pyrene	152-154	kininogen 1	Homo sapiens	12-14
16392709-1	2005	The prolonging effect of Japanese kelp (kombu) on life span was investigated in mice fed a diet containing the carcinogen benzo[a]pyrene (BaP).	Benzo(a)pyrene	122-136	prohibitin 2	Mus musculus	138-141
16254190-3	2005	Topical application to wild-type mice with benzo(a)pyrene (BaP) alone produced approximately 26% skin tumor incidence, whereas BaP treatment of p53(wt/wt)Hras(TG.AC/wt), p53(Val135/wt)Hras(wt/wt), and p53(Val135/wt)Hras(TG.AC/wt) mice produced a 75%, 77%, and 100% incidence of skin tumors, respectively.	Benzo(a)pyrene	127-130	transformation related protein 53, pseudogene	Mus musculus	144-147
16002475-0	2005	Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.	Benzo(a)pyrene	126-140	fibroblast growth factor 9	Homo sapiens	13-39
16002475-0	2005	Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.	Benzo(a)pyrene	126-140	interleukin 1 alpha	Homo sapiens	44-62
16002475-6	2005	Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent.	Benzo(a)pyrene	63-77	interleukin 1 alpha	Homo sapiens	13-22
16002475-6	2005	Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent.	Benzo(a)pyrene	63-77	interleukin 6	Homo sapiens	24-28
16002475-6	2005	Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent.	Benzo(a)pyrene	63-77	interleukin 11	Homo sapiens	30-35
16002475-6	2005	Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent.	Benzo(a)pyrene	63-77	fibroblast growth factor 9	Homo sapiens	41-46
16002475-8	2005	Treatment with MEP or benzo(a)pyrene increased IL-6 and IL-11 releases to CL5 cell medium.	Benzo(a)pyrene	22-36	interleukin 6	Homo sapiens	47-51
16002475-8	2005	Treatment with MEP or benzo(a)pyrene increased IL-6 and IL-11 releases to CL5 cell medium.	Benzo(a)pyrene	22-36	interleukin 11	Homo sapiens	56-61
16266505-4	2005	CONCLUSION: ATRA could block B (a) P-induced cell cycle promotion through cyclin D1/E2F-1 pathway in HELF.	Benzo(a)pyrene	29-36	E2F transcription factor 1 L homeolog	Xenopus laevis	84-89
16061434-1	2005	A novel and sensitive high-performance liquid chromatography (HPLC) method was developed to analyze dione metabolites of benzo[a]pyrene (BaP).	Benzo(a)pyrene	121-135	prohibitin 2	Homo sapiens	137-140
16019069-20	2005	In particular, significant correlations were highlighted between SigmaPCDDF, SigmaPCDD and particle size fraction &lt; or =2 mum, and between benzo(a)pyrene and PCB 167 and particle size fraction 4-8 mum.	Benzo(a)pyrene	142-156	pyruvate carboxylase	Homo sapiens	161-164
15919055-6	2005	Treatment of RAW264.7 cells cultured with 25 ng/ml soluble RANKL and 10(-5)M BaP for 5 days decreased osteoclast differentiation, TRAP activity levels, and resorption of bone-like substrata.	Benzo(a)pyrene	77-80	acid phosphatase 5, tartrate resistant	Mus musculus	130-134
16120219-9	2005	BaP upregulated the expression of CYP1B1 at 6-24 h and downregulated many cell cycle regulatory genes at 48-72 h. By contrast, PhIP increased the expression of many cell cycle regulatory genes.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40
15800929-0	2005	Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin.	Benzo(a)pyrene	25-39	Harvey rat sarcoma virus oncogene	Mus musculus	109-114
15800929-1	2005	Combined subcarcinogenic doses of benzo[a]pyrene (BaP) and UVA induced H-ras, but not p53, gene mutations 8 weeks before tumor emergence in SKH-1 mice.	Benzo(a)pyrene	34-48	prohibitin 2	Mus musculus	50-53
15800929-1	2005	Combined subcarcinogenic doses of benzo[a]pyrene (BaP) and UVA induced H-ras, but not p53, gene mutations 8 weeks before tumor emergence in SKH-1 mice.	Benzo(a)pyrene	34-48	Harvey rat sarcoma virus oncogene	Mus musculus	71-76
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	Benzo(a)pyrene	165-167	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	55-61
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	Benzo(a)pyrene	165-167	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	Benzo(a)pyrene	275-277	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	55-61
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	Benzo(a)pyrene	275-277	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72
15993149-1	2005	In this study, the polycyclic aromatic hydrocarbons, benzo[a]pyrene (BaP) and pyrene, were subjected to temporal ozonation.	Benzo(a)pyrene	53-67	prohibitin 2	Rattus norvegicus	69-72
15860575-3	2005	Benzo(a)pyrene (BP), a prototypical PAH, was shown to markedly impair CD34+ cell expansion and to inhibit CD34+ cell differentiation into various hematological cell lineages, including erythroid, granulomacrophagic, and megakaryocytic lineages.	Benzo(a)pyrene	0-14	CD34 molecule	Homo sapiens	70-74
15860575-3	2005	Benzo(a)pyrene (BP), a prototypical PAH, was shown to markedly impair CD34+ cell expansion and to inhibit CD34+ cell differentiation into various hematological cell lineages, including erythroid, granulomacrophagic, and megakaryocytic lineages.	Benzo(a)pyrene	0-14	CD34 molecule	Homo sapiens	106-110
15860575-3	2005	Benzo(a)pyrene (BP), a prototypical PAH, was shown to markedly impair CD34+ cell expansion and to inhibit CD34+ cell differentiation into various hematological cell lineages, including erythroid, granulomacrophagic, and megakaryocytic lineages.	Benzo(a)pyrene	16-18	CD34 molecule	Homo sapiens	70-74
15860575-3	2005	Benzo(a)pyrene (BP), a prototypical PAH, was shown to markedly impair CD34+ cell expansion and to inhibit CD34+ cell differentiation into various hematological cell lineages, including erythroid, granulomacrophagic, and megakaryocytic lineages.	Benzo(a)pyrene	16-18	CD34 molecule	Homo sapiens	106-110
15860575-5	2005	CD34+ progenitor cells were found to exhibit functional expression of the aryl hydrocarbon receptor (AhR), and the use of the pure AhR antagonist 3"-methoxy-4"-nitroflavone partially counteracted the deleterious effects of BP in CD34+ cell cultures, underlining the involvement of AhR in BP toxicity.	Benzo(a)pyrene	223-225	CD34 molecule	Homo sapiens	0-4
15860575-5	2005	CD34+ progenitor cells were found to exhibit functional expression of the aryl hydrocarbon receptor (AhR), and the use of the pure AhR antagonist 3"-methoxy-4"-nitroflavone partially counteracted the deleterious effects of BP in CD34+ cell cultures, underlining the involvement of AhR in BP toxicity.	Benzo(a)pyrene	223-225	aryl hydrocarbon receptor	Homo sapiens	131-134
15860575-5	2005	CD34+ progenitor cells were found to exhibit functional expression of the aryl hydrocarbon receptor (AhR), and the use of the pure AhR antagonist 3"-methoxy-4"-nitroflavone partially counteracted the deleterious effects of BP in CD34+ cell cultures, underlining the involvement of AhR in BP toxicity.	Benzo(a)pyrene	223-225	aryl hydrocarbon receptor	Homo sapiens	131-134
15860575-5	2005	CD34+ progenitor cells were found to exhibit functional expression of the aryl hydrocarbon receptor (AhR), and the use of the pure AhR antagonist 3"-methoxy-4"-nitroflavone partially counteracted the deleterious effects of BP in CD34+ cell cultures, underlining the involvement of AhR in BP toxicity.	Benzo(a)pyrene	288-290	CD34 molecule	Homo sapiens	0-4
15860575-5	2005	CD34+ progenitor cells were found to exhibit functional expression of the aryl hydrocarbon receptor (AhR), and the use of the pure AhR antagonist 3"-methoxy-4"-nitroflavone partially counteracted the deleterious effects of BP in CD34+ cell cultures, underlining the involvement of AhR in BP toxicity.	Benzo(a)pyrene	288-290	aryl hydrocarbon receptor	Homo sapiens	131-134
15860575-5	2005	CD34+ progenitor cells were found to exhibit functional expression of the aryl hydrocarbon receptor (AhR), and the use of the pure AhR antagonist 3"-methoxy-4"-nitroflavone partially counteracted the deleterious effects of BP in CD34+ cell cultures, underlining the involvement of AhR in BP toxicity.	Benzo(a)pyrene	288-290	aryl hydrocarbon receptor	Homo sapiens	131-134
15919055-8	2005	To investigate the ability of RANKL to reverse BaP-mediated inhibition, gene expression was determined by RT-PCR.	Benzo(a)pyrene	47-50	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	30-35
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	65-68	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	0-19
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	65-68	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	21-27
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	65-68	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	131-137
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	65-68	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	201-206
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	112-115	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	0-19
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	112-115	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	21-27
15919055-9	2005	Cytochrome P450 1B1 (CYP1B1) mRNA, one of the genes activated by BaP, was present only in the groups exposed to BaP; the levels of CYP1B1 mRNA decreased in the presence of increasing concentrations of RANKL.	Benzo(a)pyrene	112-115	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	131-137
16007257-4	2005	Chga mice displayed extreme phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c) loss of diurnal BP variation; (d) increased left ventricular mass and cavity dimensions; (e) decreased adrenal catecholamine, neuropeptide Y (Npy), and ATP contents; (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholamine and Npy levels.	Benzo(a)pyrene	122-124	chromogranin A	Mus musculus	0-4
16007257-4	2005	Chga mice displayed extreme phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c) loss of diurnal BP variation; (d) increased left ventricular mass and cavity dimensions; (e) decreased adrenal catecholamine, neuropeptide Y (Npy), and ATP contents; (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholamine and Npy levels.	Benzo(a)pyrene	146-148	chromogranin A	Mus musculus	0-4
15958554-0	2005	Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.	Benzo(a)pyrene	71-85	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33
15958554-3	2005	In this study, we have investigated CYP1B1 haplotypes present in a Spanish population and carried out functional analyses of the corresponding enzymes in yeast using benzo[a]pyrene as a substrate.	Benzo(a)pyrene	166-180	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	36-42
15958554-5	2005	The variant CYP1B1 forms were heterologously expressed with human reductase in Saccharomyces cerevisiae and kinetic analyses of benzo[a]pyrene metabolism were carried out.	Benzo(a)pyrene	128-142	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	12-18
15867368-8	2005	Forced expression of CYP1A1wt or CYP1A1v in HOSE cells resulted in nuclear localization of the enzyme and acquisition of anchorage-independent growth, which was further exacerbated following exposure to benzo(a)pyrene or 17beta-estradiol.	Benzo(a)pyrene	203-217	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	21-27
15956165-10	2005	RESULTS: The patients with JME showed a reduced BP in the dorsolateral prefrontal cortex, raphe nuclei, and hippocampus.	Benzo(a)pyrene	48-50	myoclonic epilepsy, juvenile, 2	Homo sapiens	27-30
15718251-0	2005	Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells.	Benzo(a)pyrene	48-62	nitric oxide synthase 2	Rattus norvegicus	102-106
15718251-0	2005	Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells.	Benzo(a)pyrene	64-69	nitric oxide synthase 2	Rattus norvegicus	102-106
15718251-3	2005	In the present study, the effects of B[a]P on the induction of iNOS and the signaling pathways that lead to the induction were investigated in cultured rat esophageal epithelial (RE-149) cells.	Benzo(a)pyrene	37-42	nitric oxide synthase 2	Rattus norvegicus	63-67
15795091-11	2005	In conclusion, this work shows that BP has an cumulative activity for specific IgE and Th1/Th2 cytokines production after intranasal instillation and cytokine secretion by DCs after in vitro exposure, and this phenomenon is dose-dependent.	Benzo(a)pyrene	36-38	negative elongation factor complex member C/D, Th1l	Mus musculus	87-90
15795091-11	2005	In conclusion, this work shows that BP has an cumulative activity for specific IgE and Th1/Th2 cytokines production after intranasal instillation and cytokine secretion by DCs after in vitro exposure, and this phenomenon is dose-dependent.	Benzo(a)pyrene	36-38	heart and neural crest derivatives expressed 2	Mus musculus	91-94
15864073-0	2005	The dopamine D(3) receptor-preferring partial agonist BP 897 dose-dependently attenuates the expression of amphetamine-conditioned place preference in rats.	Benzo(a)pyrene	54-56	dopamine receptor D3	Rattus norvegicus	4-26
15864073-1	2005	Previously we reported that systemic administration of the dopamine D3 receptor-preferring partial agonist BP 897 blocked the expression, but not the acquisition, of amphetamine-conditioned activity.	Benzo(a)pyrene	107-109	dopamine receptor D3	Rattus norvegicus	59-79
15867368-8	2005	Forced expression of CYP1A1wt or CYP1A1v in HOSE cells resulted in nuclear localization of the enzyme and acquisition of anchorage-independent growth, which was further exacerbated following exposure to benzo(a)pyrene or 17beta-estradiol.	Benzo(a)pyrene	203-217	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-40
15657916-0	2005	In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice.	Benzo(a)pyrene	31-45	glutamic pyruvic transaminase, soluble	Mus musculus	73-76
15681594-10	2005	Treatment of AhR-expressing B cells with a prototypic environmental AhR ligand, benzo[a]pyrene, significantly suppressed cell growth.	Benzo(a)pyrene	80-94	aryl hydrocarbon receptor	Homo sapiens	13-16
15681594-10	2005	Treatment of AhR-expressing B cells with a prototypic environmental AhR ligand, benzo[a]pyrene, significantly suppressed cell growth.	Benzo(a)pyrene	80-94	aryl hydrocarbon receptor	Homo sapiens	68-71
15938853-0	2005	[Relationship between JWA expression and DNA damage-repair in human embryonic lung cells by benzo(a) pyrene].	Benzo(a)pyrene	92-107	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	22-25
15938853-1	2005	OBJECTIVE: To investigate the expressions of JWA gene and heat shock protein 70 (hsp70) in human embryonic lung (cccHPF-1) cells after exposure to activated benzo(a)pyrene (B(a)P), and to explore the role and the possible mechanism of JWA gene involved in B(a)P-induced DNA damage and repair.	Benzo(a)pyrene	157-171	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	45-48
15938853-1	2005	OBJECTIVE: To investigate the expressions of JWA gene and heat shock protein 70 (hsp70) in human embryonic lung (cccHPF-1) cells after exposure to activated benzo(a)pyrene (B(a)P), and to explore the role and the possible mechanism of JWA gene involved in B(a)P-induced DNA damage and repair.	Benzo(a)pyrene	157-171	heat shock protein family A (Hsp70) member 4	Homo sapiens	81-86
15808407-0	2005	Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene.	Benzo(a)pyrene	125-139	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
15808407-0	2005	Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene.	Benzo(a)pyrene	125-139	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
15808407-7	2005	On a per-person basis, CYP1A1 and CYP1B1 induction were well-correlated (r=0.88, P&lt;0.001), which is to be expected as they are under the control of a common transcriptional regulation mechanism in response to BP exposure.	Benzo(a)pyrene	212-214	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-29
15808407-7	2005	On a per-person basis, CYP1A1 and CYP1B1 induction were well-correlated (r=0.88, P&lt;0.001), which is to be expected as they are under the control of a common transcriptional regulation mechanism in response to BP exposure.	Benzo(a)pyrene	212-214	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40
15637092-4	2005	The biological relevance of B[a]P and 7,8-diol-B[a]P redistribution by antibody was demonstrated by reversion of B[a]P-induced inhibition of proliferation of human peripheral blood lymphocytes and by inhibition of CYP 1A1 induction in HepG2 cells.	Benzo(a)pyrene	28-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	214-221
15637092-4	2005	The biological relevance of B[a]P and 7,8-diol-B[a]P redistribution by antibody was demonstrated by reversion of B[a]P-induced inhibition of proliferation of human peripheral blood lymphocytes and by inhibition of CYP 1A1 induction in HepG2 cells.	Benzo(a)pyrene	47-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	214-221
15661813-4	2005	BaP also dramatically induced CYP1A1 activity, protein expression and mRNA levels, the likely reason for the marked increase in DNA binding.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
15661813-9	2005	DMF also inhibited BaP-induced CYP1A1 activity, CYP1A1 protein expression and mRNA levels.	Benzo(a)pyrene	19-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
15661813-9	2005	DMF also inhibited BaP-induced CYP1A1 activity, CYP1A1 protein expression and mRNA levels.	Benzo(a)pyrene	19-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
15661813-11	2005	In conclusion, DMF was a highly potent inhibitor of BaP-induced DNA binding and CYP1A1 protein expression and activity in the Hep G2 cells.	Benzo(a)pyrene	52-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
15805253-5	2005	With the Hupki assay we examined here whether benzo(a)pyrene (BaP), a major tobacco smoke carcinogen could elicit p53 mutation patterns characterizing the human lung tumor p53 mutation spectrum.	Benzo(a)pyrene	46-60	prohibitin 2	Homo sapiens	62-65
15805253-5	2005	With the Hupki assay we examined here whether benzo(a)pyrene (BaP), a major tobacco smoke carcinogen could elicit p53 mutation patterns characterizing the human lung tumor p53 mutation spectrum.	Benzo(a)pyrene	46-60	tumor protein p53	Homo sapiens	114-117
15805253-5	2005	With the Hupki assay we examined here whether benzo(a)pyrene (BaP), a major tobacco smoke carcinogen could elicit p53 mutation patterns characterizing the human lung tumor p53 mutation spectrum.	Benzo(a)pyrene	46-60	tumor protein p53	Homo sapiens	172-175
15590756-2	2005	In an effort to identify a possible mechanistic link between VD and these salutary effects, the role of VD in controlling the activity and expression of the type A natriuretic peptide receptor (NPR-A), a receptor that signals reductions in BP and suppression of cellular growth in the myocardium and vascular wall, was investigated.	Benzo(a)pyrene	240-242	opioid related nociceptin receptor 1	Rattus norvegicus	176-192
15837074-0	2005	Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway.	Benzo(a)pyrene	0-14	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-77
15837074-0	2005	Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway.	Benzo(a)pyrene	0-14	tumor protein p53	Homo sapiens	82-85
15837074-3	2005	This study compared the effects of the benzo[a]pyrene (BaP) with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the prototype ligand for the aryl hydrocarbon (Ah) receptor, on proliferation and cell cycle progression in the human trophoblastic JEG-3 cell line.	Benzo(a)pyrene	39-53	prohibitin 2	Homo sapiens	55-58
15837074-3	2005	This study compared the effects of the benzo[a]pyrene (BaP) with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the prototype ligand for the aryl hydrocarbon (Ah) receptor, on proliferation and cell cycle progression in the human trophoblastic JEG-3 cell line.	Benzo(a)pyrene	39-53	aryl hydrocarbon receptor	Homo sapiens	138-168
15792794-0	2005	ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages.	Benzo(a)pyrene	80-94	mitogen-activated protein kinase 1	Homo sapiens	0-3
15792794-0	2005	ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages.	Benzo(a)pyrene	80-94	tumor necrosis factor	Homo sapiens	27-35
15792794-1	2005	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta.	Benzo(a)pyrene	48-62	interleukin 1 beta	Homo sapiens	171-179
15792794-1	2005	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta.	Benzo(a)pyrene	64-66	interleukin 1 beta	Homo sapiens	171-179
15792794-3	2005	Both TNFalpha mRNA and TNFalpha secretion levels were found to be enhanced in human BP-treated macrophages.	Benzo(a)pyrene	84-86	tumor necrosis factor	Homo sapiens	5-13
15792794-3	2005	Both TNFalpha mRNA and TNFalpha secretion levels were found to be enhanced in human BP-treated macrophages.	Benzo(a)pyrene	84-86	tumor necrosis factor	Homo sapiens	23-31
15792794-5	2005	BP-mediated TNFalpha induction was however not suppressed by AhR antagonists, making unlikely the involvement of the typical AhR signalling pathway.	Benzo(a)pyrene	0-2	tumor necrosis factor	Homo sapiens	12-20
15792794-6	2005	BP-exposure of macrophages did not enhance NF-kappaB DNA binding activity, but it activated the MAP kinase ERK1/2.	Benzo(a)pyrene	0-2	mitogen-activated protein kinase 3	Homo sapiens	107-113
15792794-7	2005	In addition, the use of chemical inhibitors of extracellular signal-regulated protein kinase (ERK) activation fully abrogated induction of TNFalpha production in BP-treated macrophages.	Benzo(a)pyrene	162-164	mitogen-activated protein kinase 1	Homo sapiens	47-92
15792794-7	2005	In addition, the use of chemical inhibitors of extracellular signal-regulated protein kinase (ERK) activation fully abrogated induction of TNFalpha production in BP-treated macrophages.	Benzo(a)pyrene	162-164	mitogen-activated protein kinase 1	Homo sapiens	94-97
15792794-7	2005	In addition, the use of chemical inhibitors of extracellular signal-regulated protein kinase (ERK) activation fully abrogated induction of TNFalpha production in BP-treated macrophages.	Benzo(a)pyrene	162-164	tumor necrosis factor	Homo sapiens	139-147
15701509-4	2005	A detailed NMR study indicates that the 10R (-)-trans-anti-[BP]G adduct undergoes a transition from a minor groove-binding alignment of the aromatic BP ring system in the unmethylated C-[BP]G sequence context, to an intercalative BP alignment with a concomitant displacement of the modified guanine residue into the minor groove in the methylated meC-[BP]G sequence context.	Benzo(a)pyrene	60-62	C-C motif chemokine ligand 28	Homo sapiens	347-350
15701509-4	2005	A detailed NMR study indicates that the 10R (-)-trans-anti-[BP]G adduct undergoes a transition from a minor groove-binding alignment of the aromatic BP ring system in the unmethylated C-[BP]G sequence context, to an intercalative BP alignment with a concomitant displacement of the modified guanine residue into the minor groove in the methylated meC-[BP]G sequence context.	Benzo(a)pyrene	149-151	C-C motif chemokine ligand 28	Homo sapiens	347-350
15701509-4	2005	A detailed NMR study indicates that the 10R (-)-trans-anti-[BP]G adduct undergoes a transition from a minor groove-binding alignment of the aromatic BP ring system in the unmethylated C-[BP]G sequence context, to an intercalative BP alignment with a concomitant displacement of the modified guanine residue into the minor groove in the methylated meC-[BP]G sequence context.	Benzo(a)pyrene	149-151	C-C motif chemokine ligand 28	Homo sapiens	347-350
15701509-4	2005	A detailed NMR study indicates that the 10R (-)-trans-anti-[BP]G adduct undergoes a transition from a minor groove-binding alignment of the aromatic BP ring system in the unmethylated C-[BP]G sequence context, to an intercalative BP alignment with a concomitant displacement of the modified guanine residue into the minor groove in the methylated meC-[BP]G sequence context.	Benzo(a)pyrene	149-151	C-C motif chemokine ligand 28	Homo sapiens	347-350
15713371-2	2005	Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-56
15713371-2	2005	Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	58-64
15713371-2	2005	Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes.	Benzo(a)pyrene	16-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-56
15713371-2	2005	Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes.	Benzo(a)pyrene	16-21	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	58-64
15713371-4	2005	However, co-treatment with 1.0 microM SAHA and BP, reduced the mRNA levels of CYP1B1 relative to B[a]P alone.	Benzo(a)pyrene	47-49	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	78-84
15713371-5	2005	When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone.	Benzo(a)pyrene	40-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
15713371-5	2005	When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone.	Benzo(a)pyrene	40-42	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	94-100
15713371-5	2005	When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone.	Benzo(a)pyrene	126-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
15713371-5	2005	When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone.	Benzo(a)pyrene	126-128	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	94-100
15608128-6	2005	In the present study, we examined the activity of human CYP2S1 in the metabolism of nicotine and in the activation of three potent carcinogens in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo[a]pyrene (BaP), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).	Benzo(a)pyrene	217-231	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	56-62
15608128-6	2005	In the present study, we examined the activity of human CYP2S1 in the metabolism of nicotine and in the activation of three potent carcinogens in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo[a]pyrene (BaP), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).	Benzo(a)pyrene	233-236	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	56-62
15625077-8	2005	Thus, in HepG2 cells pravastatin and simvastatin pretreatment attenuated the p53 response to DNA damage induced by 5-fluorouracil and benzo(a)pyrene.	Benzo(a)pyrene	134-148	tumor protein p53	Homo sapiens	77-80
15901049-5	2005	Significantly decreased concentrations of beta2-MG, IL-6 and total protein were found in both BAP and BP.	Benzo(a)pyrene	102-104	interleukin 6	Homo sapiens	52-56
15740759-7	2005	Consequently, the average daily intake of benzo(a)pyrene (BaP) by an adult Czech through fruits and vegetables was estimated with the crop-specific models to be 190 ng BaP per person, and 460 ng BaP per person with the T&amp;A regression, for a soil concentration of 1 mg BaP kg(-1) soil (wet wt.).	Benzo(a)pyrene	42-56	prohibitin 2	Homo sapiens	58-61
15740759-7	2005	Consequently, the average daily intake of benzo(a)pyrene (BaP) by an adult Czech through fruits and vegetables was estimated with the crop-specific models to be 190 ng BaP per person, and 460 ng BaP per person with the T&amp;A regression, for a soil concentration of 1 mg BaP kg(-1) soil (wet wt.).	Benzo(a)pyrene	42-56	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	134-138
15740759-7	2005	Consequently, the average daily intake of benzo(a)pyrene (BaP) by an adult Czech through fruits and vegetables was estimated with the crop-specific models to be 190 ng BaP per person, and 460 ng BaP per person with the T&amp;A regression, for a soil concentration of 1 mg BaP kg(-1) soil (wet wt.).	Benzo(a)pyrene	42-56	prohibitin 2	Homo sapiens	168-171
15740759-7	2005	Consequently, the average daily intake of benzo(a)pyrene (BaP) by an adult Czech through fruits and vegetables was estimated with the crop-specific models to be 190 ng BaP per person, and 460 ng BaP per person with the T&amp;A regression, for a soil concentration of 1 mg BaP kg(-1) soil (wet wt.).	Benzo(a)pyrene	42-56	prohibitin 2	Homo sapiens	168-171
15740759-7	2005	Consequently, the average daily intake of benzo(a)pyrene (BaP) by an adult Czech through fruits and vegetables was estimated with the crop-specific models to be 190 ng BaP per person, and 460 ng BaP per person with the T&amp;A regression, for a soil concentration of 1 mg BaP kg(-1) soil (wet wt.).	Benzo(a)pyrene	42-56	prohibitin 2	Homo sapiens	168-171
15652450-11	2005	This partial role of IL-10 in the early BP response of primate pregnancy may be relevant to pathophysiological states of human pregnancy such as preeclampsia.	Benzo(a)pyrene	40-42	interleukin 10	Homo sapiens	21-26
15735009-5	2005	Increase in expression of cytochrome P450 (CYP) genes was observed in response to BP exposure (CYP1A1 and CYP1B1; signal log ratio of 4.7 and 2.5, respectively).	Benzo(a)pyrene	82-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101
15735009-5	2005	Increase in expression of cytochrome P450 (CYP) genes was observed in response to BP exposure (CYP1A1 and CYP1B1; signal log ratio of 4.7 and 2.5, respectively).	Benzo(a)pyrene	82-84	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	106-112
15713329-7	2005	The model results were used to determine the dose intensity (dose per unit airway surface area) of Benzo[a]pyrene (BaP) in the respiratory tract for subjects of various ages.	Benzo(a)pyrene	99-113	prohibitin 2	Homo sapiens	115-118
15705463-2	2005	Research published in 1996 by Denissenko and colleagues demonstrated patterned in-vitro mutagenic effects on p53 of benzo[a]pyrene, a carcinogen present in tobacco smoke.	Benzo(a)pyrene	116-130	tumor protein p53	Homo sapiens	109-112
15649379-4	2005	By optimization of assay conditions on cell number and serum concentration, the fast-track DRESSA enabled detection of 0.5 pM 2,3,7,8-tetrachlorodibenzo-p-dioxin within 6 h. It also enabled detection of 10 pM 3-methylcholanthrene, 100 pM benzo[a]pyrene, and 100 pM beta-naphthoflavone within 6-16 h. By combination with the AhR antagonist alpha-naphthoflavone, nonspecific, false-positive responses could be eliminated.	Benzo(a)pyrene	238-252	aryl hydrocarbon receptor	Homo sapiens	324-327
15590756-2	2005	In an effort to identify a possible mechanistic link between VD and these salutary effects, the role of VD in controlling the activity and expression of the type A natriuretic peptide receptor (NPR-A), a receptor that signals reductions in BP and suppression of cellular growth in the myocardium and vascular wall, was investigated.	Benzo(a)pyrene	240-242	natriuretic peptide receptor 1	Rattus norvegicus	194-199
15822860-6	2005	The acceleration of two enzymatic reactions may contribute to the rapid elimination of BP; the first step, the formation of a metabolic intermediate (which is mutagenic) by CYP1A2 and the second, the conjugation of active metabolic intermediates by UGT.	Benzo(a)pyrene	87-89	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	173-179
15630410-6	2005	Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P &lt; 1 x 10(-8)) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population.	Benzo(a)pyrene	244-246	granzyme M	Homo sapiens	195-200
15548639-1	2005	Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), are carcinogens suggested to be involved in development of human cancer.	Benzo(a)pyrene	49-63	prohibitin 2	Homo sapiens	65-68
15667830-0	2005	Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.	Benzo(a)pyrene	52-66	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	13-19
15667830-0	2005	Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.	Benzo(a)pyrene	52-66	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	24-30
15667830-4	2005	BM toxicity by BP is restored in congenic mice expressing a weakly responsive aryl hydrocarbon receptor (AhR(d) replaces AhR(b)).	Benzo(a)pyrene	15-17	aryl-hydrocarbon receptor	Mus musculus	78-103
15667830-4	2005	BM toxicity by BP is restored in congenic mice expressing a weakly responsive aryl hydrocarbon receptor (AhR(d) replaces AhR(b)).	Benzo(a)pyrene	15-17	aryl-hydrocarbon receptor	Mus musculus	105-108
15667830-4	2005	BM toxicity by BP is restored in congenic mice expressing a weakly responsive aryl hydrocarbon receptor (AhR(d) replaces AhR(b)).	Benzo(a)pyrene	15-17	aryl-hydrocarbon receptor	Mus musculus	121-124
15667830-5	2005	BP strongly induces CYP1A1 around the hepatic vein whereas DMBA produces a weaker diffuse response, paralleling differences in CYP1A1 protein.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-26
15667830-7	2005	BP and DMBA broadly and equally induce CYP1A1 in the lung, while CYP1B1 is induced in bronchial blood vessels.	Benzo(a)pyrene	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	39-45
15667830-11	2005	Effective delivery of BP to BM is indicated by formation of BP-quinone DNA adducts and the effective induction of CYP1B1.	Benzo(a)pyrene	22-24	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	114-120
15641149-8	2005	CONCLUSION: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression.	Benzo(a)pyrene	57-60	transformation related protein 53, pseudogene	Mus musculus	129-132
16227674-7	2005	Altered metabolism of benzo(a)pyrene due to the polymorphism in the CYP1A1 gene might be an etiologic factor in the increased incidence of AA in these patients.	Benzo(a)pyrene	22-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	68-74
15665283-11	2005	Rassf1a(-/-) and wild-type mice were treated with two chemical carcinogens, benzo(a)pyrene and urethane, to induce skin tumors and lung tumors, respectively.	Benzo(a)pyrene	76-90	Ras association (RalGDS/AF-6) domain family member 1	Mus musculus	0-7
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	Benzo(a)pyrene	103-117	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15626640-7	2005	Liquid chromatography-mass spectrometry analysis confirmed the microbial PAH transformation by the detection of PAH metabolites 1-hydroxypyrene and 7-hydroxybenzo(a)pyrene in colon digests of pyrene and benzo(a)pyrene.	Benzo(a)pyrene	157-171	phenylalanine hydroxylase	Homo sapiens	73-76
15626640-7	2005	Liquid chromatography-mass spectrometry analysis confirmed the microbial PAH transformation by the detection of PAH metabolites 1-hydroxypyrene and 7-hydroxybenzo(a)pyrene in colon digests of pyrene and benzo(a)pyrene.	Benzo(a)pyrene	157-171	phenylalanine hydroxylase	Homo sapiens	112-115
21783461-0	2005	Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.	Benzo(a)pyrene	39-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
21783461-3	2005	Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity.	Benzo(a)pyrene	36-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-127
21783461-3	2005	Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity.	Benzo(a)pyrene	36-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	129-132
21783461-3	2005	Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity.	Benzo(a)pyrene	52-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-127
21783461-3	2005	Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity.	Benzo(a)pyrene	52-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	129-132
21783461-8	2005	BaP itself exhibited estrogenicity in the ER-CALUX assay due to bio-activation into estrogenic metabolites, probably via aryl hydrocarbon receptor (AhR) induced CYP activity.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	121-146
21783461-8	2005	BaP itself exhibited estrogenicity in the ER-CALUX assay due to bio-activation into estrogenic metabolites, probably via aryl hydrocarbon receptor (AhR) induced CYP activity.	Benzo(a)pyrene	0-3	aryl hydrocarbon receptor	Homo sapiens	148-151
21783461-8	2005	BaP itself exhibited estrogenicity in the ER-CALUX assay due to bio-activation into estrogenic metabolites, probably via aryl hydrocarbon receptor (AhR) induced CYP activity.	Benzo(a)pyrene	0-3	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	161-164
15618000-0	2005	CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.	Benzo(a)pyrene	40-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
15563565-8	2005	Minipump infusion of angiotensin II to Ren1c-/- mice restores BP to wild-type level, but preexisting damage to the medulla prevents complete restoration of the ability of the kidney to concentrate urine.	Benzo(a)pyrene	62-64	renin 1 structural	Mus musculus	39-44
15519607-0	2004	Benzo[a]pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression.	Benzo(a)pyrene	0-14	cytochrome P450 1A1	Oryzias latipes	106-111
16050805-7	2005	We serially examined the histopathological changes in the lung of mice administered benzo(a)pyrene and correlated them with the frequency of proliferative and apoptotic cells in situ as well as with the expression of H-ras, c-Myc, p53, and Bcl-2 genes, which play key roles in the histopathogenesis of neoplasia.	Benzo(a)pyrene	84-98	Harvey rat sarcoma virus oncogene	Mus musculus	217-222
16050805-7	2005	We serially examined the histopathological changes in the lung of mice administered benzo(a)pyrene and correlated them with the frequency of proliferative and apoptotic cells in situ as well as with the expression of H-ras, c-Myc, p53, and Bcl-2 genes, which play key roles in the histopathogenesis of neoplasia.	Benzo(a)pyrene	84-98	transformation related protein 53, pseudogene	Mus musculus	231-234
16050805-7	2005	We serially examined the histopathological changes in the lung of mice administered benzo(a)pyrene and correlated them with the frequency of proliferative and apoptotic cells in situ as well as with the expression of H-ras, c-Myc, p53, and Bcl-2 genes, which play key roles in the histopathogenesis of neoplasia.	Benzo(a)pyrene	84-98	B cell leukemia/lymphoma 2	Mus musculus	240-245
16399343-5	2005	UGT1A6 is also involved in conjugation of the drug paracetamol (acetaminophen) and of phenolic metabolites of benzo[a]pyrene (together with rat UGT1A7 and human UGT1A9).	Benzo(a)pyrene	110-124	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	0-6
16399343-5	2005	UGT1A6 is also involved in conjugation of the drug paracetamol (acetaminophen) and of phenolic metabolites of benzo[a]pyrene (together with rat UGT1A7 and human UGT1A9).	Benzo(a)pyrene	110-124	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	144-150
16399343-5	2005	UGT1A6 is also involved in conjugation of the drug paracetamol (acetaminophen) and of phenolic metabolites of benzo[a]pyrene (together with rat UGT1A7 and human UGT1A9).	Benzo(a)pyrene	110-124	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	161-167
15595848-1	2004	Codon 273 ((5)(")CGT) of the human P53 gene is a mutational hot spot for the environmental carcinogen benzo[a]pyrene.	Benzo(a)pyrene	102-116	tumor protein p53	Homo sapiens	35-38
15449320-1	2004	The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis.	Benzo(a)pyrene	28-42	transformation related protein 53, pseudogene	Mus musculus	126-129
15449320-1	2004	The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis.	Benzo(a)pyrene	28-42	transformation related protein 53, pseudogene	Mus musculus	172-175
15449320-1	2004	The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis.	Benzo(a)pyrene	44-49	transformation related protein 53, pseudogene	Mus musculus	126-129
15449320-1	2004	The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis.	Benzo(a)pyrene	44-49	transformation related protein 53, pseudogene	Mus musculus	172-175
15476291-4	2004	Chloral hydrate and ketamine anesthesia significantly increased the striatal BP of DA-D(1) receptors by 36% and 46%, respectively, compared to that observed in the conscious state.	Benzo(a)pyrene	77-79	defender against cell death 1	Rattus norvegicus	83-90
15598141-0	2004	Intra-BLA or intra-NAc infusions of the dopamine D3 receptor partial agonist, BP 897, block intra-NAc amphetamine conditioned activity.	Benzo(a)pyrene	78-80	dopamine receptor D3	Rattus norvegicus	40-60
15547727-12	2004	Interesting, among the tumorigenic MCF-10F cells previously exposed to both BP and c-Ha-ras (BP1-Tras-3 Gy cell line), radiation increased the c-myc, c-jun, c-fos protein expression by more than 120% relative to the non-irradiated controls.	Benzo(a)pyrene	76-78	BP1	Homo sapiens	93-96
15547727-12	2004	Interesting, among the tumorigenic MCF-10F cells previously exposed to both BP and c-Ha-ras (BP1-Tras-3 Gy cell line), radiation increased the c-myc, c-jun, c-fos protein expression by more than 120% relative to the non-irradiated controls.	Benzo(a)pyrene	76-78	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	143-148
15547727-12	2004	Interesting, among the tumorigenic MCF-10F cells previously exposed to both BP and c-Ha-ras (BP1-Tras-3 Gy cell line), radiation increased the c-myc, c-jun, c-fos protein expression by more than 120% relative to the non-irradiated controls.	Benzo(a)pyrene	76-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-155
15547727-12	2004	Interesting, among the tumorigenic MCF-10F cells previously exposed to both BP and c-Ha-ras (BP1-Tras-3 Gy cell line), radiation increased the c-myc, c-jun, c-fos protein expression by more than 120% relative to the non-irradiated controls.	Benzo(a)pyrene	76-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-162
15663194-3	2004	In the present communication, the expression profile of HABP1 was investigated from initiation to progression of epidermal carcinoma in mice, induced by benzo[a]pyrene (B[a]P) exposure.	Benzo(a)pyrene	153-167	complement component 1, q subcomponent binding protein	Mus musculus	56-61
15748481-1	2004	OBJECTIVE: To explore the effects of selenium on DNA damage induced by benzo[a] pyrene (BaP) in mouse lung cells.	Benzo(a)pyrene	71-86	prohibitin 2	Mus musculus	88-91
15522429-9	2004	The recombinant protein also metabolized benzo(a)pyrene with a Km(app) and Vmax values of 5.34 +/- 0.58 microM and 1.16 +/- 0.13 nmol/min/nmol CYP, respectively.	Benzo(a)pyrene	41-55	amyloid beta (A4) precursor protein a	Danio rerio	63-70
15519607-4	2004	Results from rodent studies have suggested that BaP elicits its immunotoxic effects via upregulation of cytochrome P4501A1 (CYP1A1) and the subsequent production of immunosuppressive BaP metabolites.	Benzo(a)pyrene	48-51	cytochrome P450 1A1	Oryzias latipes	104-122
15519607-4	2004	Results from rodent studies have suggested that BaP elicits its immunotoxic effects via upregulation of cytochrome P4501A1 (CYP1A1) and the subsequent production of immunosuppressive BaP metabolites.	Benzo(a)pyrene	48-51	cytochrome P450 1A1	Oryzias latipes	124-130
15519607-6	2004	Concurrent injection of fish with BaP and the CYP1A1 inhibitors alpha-naphthoflavone (ANF) or dehydroepiandrosterone (DHEA) resulted in inhibition of renal EROD activity and amelioration of BaP-induced suppression of medaka AFC numbers.	Benzo(a)pyrene	190-193	cytochrome P450 1A1	Oryzias latipes	46-52
15519607-7	2004	Results of this study suggest that (1) BaP-induced suppression of medaka humoral immunity relies upon the CYP1A-catalyzed production of immunotoxic BaP metabolites and (2) BaP metabolites may be created in situ, directly by specific cells within kidney lymphoid tissue.	Benzo(a)pyrene	39-42	cytochrome P450 1A1	Oryzias latipes	106-111
15519607-7	2004	Results of this study suggest that (1) BaP-induced suppression of medaka humoral immunity relies upon the CYP1A-catalyzed production of immunotoxic BaP metabolites and (2) BaP metabolites may be created in situ, directly by specific cells within kidney lymphoid tissue.	Benzo(a)pyrene	148-151	cytochrome P450 1A1	Oryzias latipes	106-111
15519607-7	2004	Results of this study suggest that (1) BaP-induced suppression of medaka humoral immunity relies upon the CYP1A-catalyzed production of immunotoxic BaP metabolites and (2) BaP metabolites may be created in situ, directly by specific cells within kidney lymphoid tissue.	Benzo(a)pyrene	148-151	cytochrome P450 1A1	Oryzias latipes	106-111
15297370-1	2004	Several members of the P450 family, including cytochrome P450 1B1 (CYP1B1), can convert tobacco smoke (TS) procarcinogens, including benzo[a]pyrene (B[a]P), to carcinogenic intermediates.	Benzo(a)pyrene	133-147	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73
15621696-0	2004	Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	120-123
15727169-1	2004	OBJECTIVE: To explore the relationship between genetic polymorphism of NQO1 and susceptibility to benzene poisoning (BP).	Benzo(a)pyrene	117-119	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-75
15727169-4	2004	There was a trend that the risk of BP in subjects with NQO1 C609T mutation genotype (T/T) was higher than those carrying heterozygous (C/T) and even higher than those carrying wild type (C/C) (chi2(trend) = 6.01, P = 0.014).	Benzo(a)pyrene	35-37	NAD(P)H quinone dehydrogenase 1	Homo sapiens	55-59
15450432-9	2004	Expression of GST-hOGG1 also reduced by 40 and 60%, respectively, the numbers of His+ revertants induced by methylene blue plus visible light and benzo[a]pyrene plus visible light in strain YG3001.	Benzo(a)pyrene	146-160	8-oxoguanine DNA glycosylase	Homo sapiens	18-23
15563282-2	2004	Because compounds with the highest toxicity, such as dibenz(a,h)anthracene and benzo(a)pyrene (BAP), also tended to be the least rapidly and least extensively desorbed, the U.S. Environmental Protection Agency (EPA) default guidance may dramatically overestimate risk from exposure to PAH-contaminated soils or sediments.	Benzo(a)pyrene	79-93	prohibitin 2	Homo sapiens	95-98
15336901-8	2004	These results were consistent with the greater desorption of pyrene, phenanthrene and benzo(a)pyrene from the ship channel than from the creosote facility sediments.	Benzo(a)pyrene	86-100	inositol polyphosphate-5-phosphatase D	Homo sapiens	110-114
15555317-0	2004	[Expression of the heat-shock protein 70 family polymorphism in A549 cell line exposed to benzo(a)pyrene].	Benzo(a)pyrene	90-104	heat shock protein family A (Hsp70) member 4	Homo sapiens	19-40
15555317-1	2004	OBJECTIVE: To study the pattern of polymorphism expression of heat-shock protein 70 (HSP70) family in A549 cell line treated with different concentrations of benzo(a)pyrene (BaP) and its probable biological effect.	Benzo(a)pyrene	158-172	heat shock protein family A (Hsp70) member 4	Homo sapiens	62-83
15555317-1	2004	OBJECTIVE: To study the pattern of polymorphism expression of heat-shock protein 70 (HSP70) family in A549 cell line treated with different concentrations of benzo(a)pyrene (BaP) and its probable biological effect.	Benzo(a)pyrene	158-172	heat shock protein family A (Hsp70) member 4	Homo sapiens	85-90
15555317-1	2004	OBJECTIVE: To study the pattern of polymorphism expression of heat-shock protein 70 (HSP70) family in A549 cell line treated with different concentrations of benzo(a)pyrene (BaP) and its probable biological effect.	Benzo(a)pyrene	158-172	prohibitin 2	Homo sapiens	174-177
15308241-9	2004	The developed SPR sensor for HBP is free from interference by coexisting benzo[a]pyrene (BaP), 2,4-dichlorophenoxyacetic acid (2,4-D) and benz[a]anthracene; SPR angle shift obtained to the flow of HBP is almost same irrespective to the presence or absence of a same concentration of these carcinogenic polycyclic aromatic hydrocarbons together.	Benzo(a)pyrene	73-87	heme binding protein 1	Homo sapiens	29-32
15342368-9	2004	The treatment of NQO2-/- mice skin with benzo(a)pyrene failed to significantly increase tumor suppressor protein p53 and p53-regulated growth-related protein p21 and proapoptotic protein Bax as observed in case of wild-type mice.	Benzo(a)pyrene	40-54	N-ribosyldihydronicotinamide quinone reductase 2	Mus musculus	17-21
15288535-0	2004	Benzo[a]pyrene-enhanced mutagenesis by asbestos in the lung of lambda-lacI transgenic rats.	Benzo(a)pyrene	0-14	tissue factor pathway inhibitor	Rattus norvegicus	70-74
15261788-3	2004	For cell-line validation, our results demonstrated a dose-dependent increase in the Ah receptor-mediated response (i.e., CYP1A1 mRNA and EROD) of the cells upon exposure to a number of known Ah receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzothiophene, benzo[a]pyrene, and beta-naphthaflavone.	Benzo(a)pyrene	304-318	aryl hydrocarbon receptor	Homo sapiens	84-95
15261788-3	2004	For cell-line validation, our results demonstrated a dose-dependent increase in the Ah receptor-mediated response (i.e., CYP1A1 mRNA and EROD) of the cells upon exposure to a number of known Ah receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzothiophene, benzo[a]pyrene, and beta-naphthaflavone.	Benzo(a)pyrene	304-318	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-127
15261788-3	2004	For cell-line validation, our results demonstrated a dose-dependent increase in the Ah receptor-mediated response (i.e., CYP1A1 mRNA and EROD) of the cells upon exposure to a number of known Ah receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzothiophene, benzo[a]pyrene, and beta-naphthaflavone.	Benzo(a)pyrene	304-318	aryl hydrocarbon receptor	Homo sapiens	191-202
15612468-1	2004	OBJECTIVE: To explore the relation between genetic polymorphisms in XRCC1 and risks of chronic benzene poisoning (BP).	Benzo(a)pyrene	114-116	X-ray repair cross complementing 1	Homo sapiens	68-73
15612468-7	2004	CONCLUSION: The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.	Benzo(a)pyrene	24-26	X-ray repair cross complementing 1	Homo sapiens	49-54
15612468-7	2004	CONCLUSION: The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.	Benzo(a)pyrene	24-26	X-ray repair cross complementing 1	Homo sapiens	132-137
15274625-1	2004	The ultimate diol epoxide carcinogens derived from polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (BP), are metabolized primarily by glutathione (GSH) conjugation reaction catalyzed by GSH transferases (GSTs).	Benzo(a)pyrene	93-107	glutathione S-transferase alpha 1	Homo sapiens	213-217
15315710-1	2004	BACKGROUND: Benzo(a)pyrene (BaP), anthracene (ANTH) and chrysene (CHRY) are polynuclear aromatic hydrocarbons (PAHs) implicated in renal toxicity and carcinogenesis.	Benzo(a)pyrene	12-26	prohibitin 2	Homo sapiens	28-31
15274625-1	2004	The ultimate diol epoxide carcinogens derived from polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (BP), are metabolized primarily by glutathione (GSH) conjugation reaction catalyzed by GSH transferases (GSTs).	Benzo(a)pyrene	109-111	glutathione S-transferase alpha 1	Homo sapiens	213-217
15284283-4	2004	Newer drugs, including agents that block the renin-angiotensin system, have improved the level of BP control for renovascular hypertension.	Benzo(a)pyrene	98-100	renin	Homo sapiens	45-50
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Benzo(a)pyrene	32-34	endothelin 1	Mus musculus	41-45
15314687-8	2004	These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP.	Benzo(a)pyrene	117-119	endothelin 1	Mus musculus	39-43
15386940-0	2004	In vitro study on role of Hsp70 expression in DNA damage of human embryonic lung cells exposed to Benzo[a]pyrene.	Benzo(a)pyrene	98-112	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
15279838-5	2004	Benzo[a]pyrene was also activated efficiently by CYP1A1 and weakly by CYP1A2, CYP2C9, CYP2C19, and CYP3A4 expressed in TA1538.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
15279838-5	2004	Benzo[a]pyrene was also activated efficiently by CYP1A1 and weakly by CYP1A2, CYP2C9, CYP2C19, and CYP3A4 expressed in TA1538.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	70-76
15210295-5	2004	Exposure to benzo[a]pyrene (BaP) significantly increased CYP19A2 transcript abundance.	Benzo(a)pyrene	12-26	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	57-64
15210295-5	2004	Exposure to benzo[a]pyrene (BaP) significantly increased CYP19A2 transcript abundance.	Benzo(a)pyrene	28-31	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	57-64
15210295-6	2004	Furthermore, BaP when co-treated with EE partially suppressed EE-induced upregulation of CYP19A2.	Benzo(a)pyrene	13-16	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	89-96
15183459-2	2004	Benzo[a]pyrene (B[a]P) is one of the most common ingredients of cigarette smoke and benzo[a]pyrene diol epoxide (BPDE) is a metabolic product of B[a]P. Cigarette smoking-induced inflammation has been found in several tissues and in association with cyclooxygenase-2 (COX-2) expression.	Benzo(a)pyrene	0-14	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	249-265
15183459-2	2004	Benzo[a]pyrene (B[a]P) is one of the most common ingredients of cigarette smoke and benzo[a]pyrene diol epoxide (BPDE) is a metabolic product of B[a]P. Cigarette smoking-induced inflammation has been found in several tissues and in association with cyclooxygenase-2 (COX-2) expression.	Benzo(a)pyrene	0-14	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	267-272
15306462-10	2004	The effect on binding stability can be interpreted in terms of conformational freedom and major-groove space available to BP due to the hydrogen bonds and inserted phenylalanines of the TATA-TBP complex; that is, depending on the position of the adenine to which BP is covalently bound, BP can be accommodated in an intercalated or major-groove orientation with ease or with difficulty (due to interference with TATA-TBP interactions).	Benzo(a)pyrene	122-124	TATA-box binding protein	Homo sapiens	191-194
15306462-10	2004	The effect on binding stability can be interpreted in terms of conformational freedom and major-groove space available to BP due to the hydrogen bonds and inserted phenylalanines of the TATA-TBP complex; that is, depending on the position of the adenine to which BP is covalently bound, BP can be accommodated in an intercalated or major-groove orientation with ease or with difficulty (due to interference with TATA-TBP interactions).	Benzo(a)pyrene	122-124	TATA-box binding protein	Homo sapiens	417-420
15306462-10	2004	The effect on binding stability can be interpreted in terms of conformational freedom and major-groove space available to BP due to the hydrogen bonds and inserted phenylalanines of the TATA-TBP complex; that is, depending on the position of the adenine to which BP is covalently bound, BP can be accommodated in an intercalated or major-groove orientation with ease or with difficulty (due to interference with TATA-TBP interactions).	Benzo(a)pyrene	192-194	TATA-box binding protein	Homo sapiens	417-420
15306462-10	2004	The effect on binding stability can be interpreted in terms of conformational freedom and major-groove space available to BP due to the hydrogen bonds and inserted phenylalanines of the TATA-TBP complex; that is, depending on the position of the adenine to which BP is covalently bound, BP can be accommodated in an intercalated or major-groove orientation with ease or with difficulty (due to interference with TATA-TBP interactions).	Benzo(a)pyrene	192-194	TATA-box binding protein	Homo sapiens	417-420
15213263-7	2004	These results suggest that At1a receptor-mediated inputs play critical roles in maintaining renal vascular eNOS expression and activity during changes in salt-water balance and systemic BP.	Benzo(a)pyrene	186-188	angiotensin II receptor, type 1a	Mus musculus	27-31
15213263-7	2004	These results suggest that At1a receptor-mediated inputs play critical roles in maintaining renal vascular eNOS expression and activity during changes in salt-water balance and systemic BP.	Benzo(a)pyrene	186-188	nitric oxide synthase 3, endothelial cell	Mus musculus	107-111
15147799-3	2004	The results showed that oral administration of OA plus BP produced anti-OA IgE antibodies in serum, whereas either OA or BP alone failed to show the antigen-specific IgE antibody production.	Benzo(a)pyrene	55-57	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-74
15147799-3	2004	The results showed that oral administration of OA plus BP produced anti-OA IgE antibodies in serum, whereas either OA or BP alone failed to show the antigen-specific IgE antibody production.	Benzo(a)pyrene	55-57	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-74
15147799-4	2004	Production of anti-OA IgE antibody, which is dependent on Th2 CD4(+) T cells, was seen in mice fed with combined OA and BP was significantly higher than that of other groups.	Benzo(a)pyrene	120-122	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	19-21
15147799-4	2004	Production of anti-OA IgE antibody, which is dependent on Th2 CD4(+) T cells, was seen in mice fed with combined OA and BP was significantly higher than that of other groups.	Benzo(a)pyrene	120-122	heart and neural crest derivatives expressed 2	Mus musculus	58-61
15147799-4	2004	Production of anti-OA IgE antibody, which is dependent on Th2 CD4(+) T cells, was seen in mice fed with combined OA and BP was significantly higher than that of other groups.	Benzo(a)pyrene	120-122	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	113-115
15147799-6	2004	These results suggest that BP may act as a mucosal adjuvant in the gut enhancing systemic Th1 and Th2 immune responses and might play a role in oral immunization and food allergy.	Benzo(a)pyrene	27-29	negative elongation factor complex member C/D, Th1l	Mus musculus	90-93
15147799-6	2004	These results suggest that BP may act as a mucosal adjuvant in the gut enhancing systemic Th1 and Th2 immune responses and might play a role in oral immunization and food allergy.	Benzo(a)pyrene	27-29	heart and neural crest derivatives expressed 2	Mus musculus	98-101
15142772-4	2004	Benzo(a)pyrene (BaP) median values were 0.65 ng m(-3) (winter) and 0.27 ng m(-3) (spring/summer) in smokers" apartments and 0.25 ng m(-3) (winter) and 0.09 ng m(-3) (spring/summer) in the apartments of non-smokers.	Benzo(a)pyrene	0-14	prohibitin 2	Homo sapiens	16-19
15189446-3	2004	Unlike Poleta encoded by the xeroderma pigmentosum variant (XPV) gene, Polkappa is unable to bypass UV-induced DNA damage in vitro, but it is able to bypass benzo[a]pyrene (B[a]P)-adducted guanines accurately and efficiently.	Benzo(a)pyrene	157-171	DNA polymerase lambda	Homo sapiens	71-79
14741058-6	2004	In the dorsolateral prefrontal cortex Brodmann"s area 9 (BA 9), MR mRNA was significantly lower (p&lt;0.05) in all laminae (I-VI) in BP, and in laminae I, III, IV and VI in SZ than in the controls.	Benzo(a)pyrene	133-135	nuclear receptor subfamily 3 group C member 2	Homo sapiens	64-66
15170813-0	2004	Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene-4,5 epoxide, and benzo[a]pyrene-7,8-9,10 diol epoxide.	Benzo(a)pyrene	107-121	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	13-18
14578163-1	2004	Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread.	Benzo(a)pyrene	85-99	prohibitin 2	Mus musculus	101-104
15125997-1	2004	Benzo(a)pyrene (BaP), a potent carcinogen, has been shown to induce apoptosis via activation of caspase-3.	Benzo(a)pyrene	0-14	caspase 3	Mus musculus	96-105
15125997-1	2004	Benzo(a)pyrene (BaP), a potent carcinogen, has been shown to induce apoptosis via activation of caspase-3.	Benzo(a)pyrene	16-19	caspase 3	Mus musculus	96-105
15125997-5	2004	BaP also induced the mitochondrial dysfunction, including transition of mitochondria membrane potential and cytosolic release of cytochrome c. Furthermore, a decrease in the expression of Bcl-2 to Bax ratio and phosphorylation of p53(Ser 15) were observed in BaP-treated cells.	Benzo(a)pyrene	0-3	B cell leukemia/lymphoma 2	Mus musculus	188-193
15125997-5	2004	BaP also induced the mitochondrial dysfunction, including transition of mitochondria membrane potential and cytosolic release of cytochrome c. Furthermore, a decrease in the expression of Bcl-2 to Bax ratio and phosphorylation of p53(Ser 15) were observed in BaP-treated cells.	Benzo(a)pyrene	0-3	BCL2-associated X protein	Mus musculus	197-200
15125997-5	2004	BaP also induced the mitochondrial dysfunction, including transition of mitochondria membrane potential and cytosolic release of cytochrome c. Furthermore, a decrease in the expression of Bcl-2 to Bax ratio and phosphorylation of p53(Ser 15) were observed in BaP-treated cells.	Benzo(a)pyrene	0-3	transformation related protein 53, pseudogene	Mus musculus	230-233
15125997-5	2004	BaP also induced the mitochondrial dysfunction, including transition of mitochondria membrane potential and cytosolic release of cytochrome c. Furthermore, a decrease in the expression of Bcl-2 to Bax ratio and phosphorylation of p53(Ser 15) were observed in BaP-treated cells.	Benzo(a)pyrene	259-262	transformation related protein 53, pseudogene	Mus musculus	230-233
15125997-6	2004	Taken together, these results demonstrated that BaP-induced apoptosis of Hepa1c1c7 cells via activation of intrinsic caspase pathway including caspase-3, caspase-9, with mitochondrial dysfunction and p53 activation.	Benzo(a)pyrene	48-51	caspase 3	Mus musculus	143-152
15125997-6	2004	Taken together, these results demonstrated that BaP-induced apoptosis of Hepa1c1c7 cells via activation of intrinsic caspase pathway including caspase-3, caspase-9, with mitochondrial dysfunction and p53 activation.	Benzo(a)pyrene	48-51	caspase 9	Mus musculus	154-163
15125997-6	2004	Taken together, these results demonstrated that BaP-induced apoptosis of Hepa1c1c7 cells via activation of intrinsic caspase pathway including caspase-3, caspase-9, with mitochondrial dysfunction and p53 activation.	Benzo(a)pyrene	48-51	transformation related protein 53, pseudogene	Mus musculus	200-203
15256148-1	2004	OBJECTIVE: To explore the relationship between genetic polymorphisms of microsomal epoxide hydrolase (mEH) and susceptibility of chronic benzene poisoning (BP).	Benzo(a)pyrene	156-158	epoxide hydrolase 1	Homo sapiens	72-100
15256148-1	2004	OBJECTIVE: To explore the relationship between genetic polymorphisms of microsomal epoxide hydrolase (mEH) and susceptibility of chronic benzene poisoning (BP).	Benzo(a)pyrene	156-158	epoxide hydrolase 1, microsomal	Mus musculus	102-105
15150120-3	2004	Results from an indirect immunofluorescent antibody assay showed that GNMT was expressed in cell cytoplasm before BaP treatment and translocated to cell nuclei after BaP treatment.	Benzo(a)pyrene	114-117	glycine N-methyltransferase	Homo sapiens	70-74
15150120-3	2004	Results from an indirect immunofluorescent antibody assay showed that GNMT was expressed in cell cytoplasm before BaP treatment and translocated to cell nuclei after BaP treatment.	Benzo(a)pyrene	166-169	glycine N-methyltransferase	Homo sapiens	70-74
15150120-6	2004	According to an aryl hydrocarbon hydroxylase enzyme activity assay, GNMT inhibited BaP-induced cytochrome P450 1A1 enzyme activity.	Benzo(a)pyrene	83-86	glycine N-methyltransferase	Homo sapiens	68-72
15150120-6	2004	According to an aryl hydrocarbon hydroxylase enzyme activity assay, GNMT inhibited BaP-induced cytochrome P450 1A1 enzyme activity.	Benzo(a)pyrene	83-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-114
15150120-7	2004	Automated BaP docking using a Lamarckian genetic algorithm with GNMT X-ray crystallography revealed a BaP preference for the S-adenosylmethionine-binding domain of the dimeric form of GNMT, a novel finding of a cellular defense against potentially damaging exposures.	Benzo(a)pyrene	10-13	glycine N-methyltransferase	Homo sapiens	64-68
15150120-7	2004	Automated BaP docking using a Lamarckian genetic algorithm with GNMT X-ray crystallography revealed a BaP preference for the S-adenosylmethionine-binding domain of the dimeric form of GNMT, a novel finding of a cellular defense against potentially damaging exposures.	Benzo(a)pyrene	10-13	glycine N-methyltransferase	Homo sapiens	184-188
15150120-7	2004	Automated BaP docking using a Lamarckian genetic algorithm with GNMT X-ray crystallography revealed a BaP preference for the S-adenosylmethionine-binding domain of the dimeric form of GNMT, a novel finding of a cellular defense against potentially damaging exposures.	Benzo(a)pyrene	102-105	glycine N-methyltransferase	Homo sapiens	64-68
15150120-7	2004	Automated BaP docking using a Lamarckian genetic algorithm with GNMT X-ray crystallography revealed a BaP preference for the S-adenosylmethionine-binding domain of the dimeric form of GNMT, a novel finding of a cellular defense against potentially damaging exposures.	Benzo(a)pyrene	102-105	glycine N-methyltransferase	Homo sapiens	184-188
15150120-8	2004	In addition to GNMT, results from docking experiments showed that BaP binds readily with other DNA methyltransferases, including HhaI, HaeIII, PvuII methyltransferases and human DNA methyltransferase 2.	Benzo(a)pyrene	66-69	glycine N-methyltransferase	Homo sapiens	15-19
15150120-8	2004	In addition to GNMT, results from docking experiments showed that BaP binds readily with other DNA methyltransferases, including HhaI, HaeIII, PvuII methyltransferases and human DNA methyltransferase 2.	Benzo(a)pyrene	66-69	tRNA aspartic acid methyltransferase 1	Homo sapiens	178-201
15081398-3	2004	BP-treatment was found to dramatically alter their functional capacities and to trigger a caspase- and mitochondrion-related apoptosis, associated with down-regulation of the survival factors c-FLIP(L) and Bcl-X(L) and up-regulation of the pro-apoptotic factor p53.	Benzo(a)pyrene	0-2	CASP8 and FADD like apoptosis regulator	Homo sapiens	192-198
15081398-3	2004	BP-treatment was found to dramatically alter their functional capacities and to trigger a caspase- and mitochondrion-related apoptosis, associated with down-regulation of the survival factors c-FLIP(L) and Bcl-X(L) and up-regulation of the pro-apoptotic factor p53.	Benzo(a)pyrene	0-2	BCL2 like 1	Homo sapiens	206-214
15081398-3	2004	BP-treatment was found to dramatically alter their functional capacities and to trigger a caspase- and mitochondrion-related apoptosis, associated with down-regulation of the survival factors c-FLIP(L) and Bcl-X(L) and up-regulation of the pro-apoptotic factor p53.	Benzo(a)pyrene	0-2	tumor protein p53	Homo sapiens	261-264
15081398-4	2004	Such deleterious effects were associated with BP metabolite production, whose inhibition by the cytochrome P-450 1A1 inhibitor alpha-naphthoflavone fully abolished BP toxicity.	Benzo(a)pyrene	46-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-116
15081398-4	2004	Such deleterious effects were associated with BP metabolite production, whose inhibition by the cytochrome P-450 1A1 inhibitor alpha-naphthoflavone fully abolished BP toxicity.	Benzo(a)pyrene	164-166	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-116
15081870-1	2004	We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor.	Benzo(a)pyrene	237-251	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-144
15081870-1	2004	We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor.	Benzo(a)pyrene	253-255	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-144
15081870-5	2004	Inhibition of CYP1 activity by EIPA was associated with a decreased metabolism of BP, a reduced formation of BP-derived DNA adducts and a diminished BP-induced apoptosis in liver cells.	Benzo(a)pyrene	82-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-18
15081870-5	2004	Inhibition of CYP1 activity by EIPA was associated with a decreased metabolism of BP, a reduced formation of BP-derived DNA adducts and a diminished BP-induced apoptosis in liver cells.	Benzo(a)pyrene	109-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-18
15081870-5	2004	Inhibition of CYP1 activity by EIPA was associated with a decreased metabolism of BP, a reduced formation of BP-derived DNA adducts and a diminished BP-induced apoptosis in liver cells.	Benzo(a)pyrene	109-111	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-18
15144225-0	2004	Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway.	Benzo(a)pyrene	0-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-103
15144225-7	2004	Western blot analysis showed that benzo[a]pyrene could induce the phosphorylation of ERK1/2 and Akt (PI3K downstream effector) in osteoblasts.	Benzo(a)pyrene	34-48	mitogen-activated protein kinase 3	Homo sapiens	85-91
15144225-7	2004	Western blot analysis showed that benzo[a]pyrene could induce the phosphorylation of ERK1/2 and Akt (PI3K downstream effector) in osteoblasts.	Benzo(a)pyrene	34-48	AKT serine/threonine kinase 1	Homo sapiens	96-99
15144225-9	2004	Moreover, cyclooxygenase-2 (COX-2), but not COX-1, expression could be induced in osteoblasts under benzo[a]pyrene treatment.	Benzo(a)pyrene	100-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	10-26
15144225-9	2004	Moreover, cyclooxygenase-2 (COX-2), but not COX-1, expression could be induced in osteoblasts under benzo[a]pyrene treatment.	Benzo(a)pyrene	100-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-33
15144225-11	2004	COX-2 inhibitors NS398 and aspirin are capable of inhibiting the benzo[a]pyrene-induced osteoblast proliferation.	Benzo(a)pyrene	65-79	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
15144225-12	2004	These results indicate that benzo[a]pyrene may modulate the osteoblast proliferation through activation of COX-2 protein.	Benzo(a)pyrene	28-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-112
15211619-7	2004	Statistically significant increases in mRNA expressions, protein concentrations and catalytic activities of CYP1A1 were observed in animals exposed to BaP, to BaP coated onto (56)Fe(2)O(3) particles or to BaP coated onto (54)Fe(2)O(3) particles versus controls.	Benzo(a)pyrene	151-154	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	108-114
15211619-7	2004	Statistically significant increases in mRNA expressions, protein concentrations and catalytic activities of CYP1A1 were observed in animals exposed to BaP, to BaP coated onto (56)Fe(2)O(3) particles or to BaP coated onto (54)Fe(2)O(3) particles versus controls.	Benzo(a)pyrene	159-162	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	108-114
15211619-7	2004	Statistically significant increases in mRNA expressions, protein concentrations and catalytic activities of CYP1A1 were observed in animals exposed to BaP, to BaP coated onto (56)Fe(2)O(3) particles or to BaP coated onto (54)Fe(2)O(3) particles versus controls.	Benzo(a)pyrene	159-162	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	108-114
15211619-8	2004	Both of the BaP/Fe(2)O(3) mixtures induced higher CYP1A1 protein levels and EROD activities than BaP alone.	Benzo(a)pyrene	12-15	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	50-56
15211619-9	2004	Iron oxide particles per se did not affect mRNA levels of cyp1a1 but only enhanced BaP-mediated increases of CYP1A1 protein levels and activity.	Benzo(a)pyrene	83-86	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	109-115
15211619-11	2004	Taken together, these novel data support the hypothesis that the Fe(2)O(3)-induced increases of the metabolic activation of BaP might rely on the property of Fe(2)O(3) particles to enhance the BaP-induced translation rate of the cyp1a1 gene into functional haemoproteins.	Benzo(a)pyrene	124-127	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	229-235
15211619-11	2004	Taken together, these novel data support the hypothesis that the Fe(2)O(3)-induced increases of the metabolic activation of BaP might rely on the property of Fe(2)O(3) particles to enhance the BaP-induced translation rate of the cyp1a1 gene into functional haemoproteins.	Benzo(a)pyrene	193-196	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	229-235
15102951-1	2004	The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis.	Benzo(a)pyrene	109-123	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-27
15102951-1	2004	The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis.	Benzo(a)pyrene	109-123	prohibitin 2	Mus musculus	125-128
14976333-12	2004	At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro.	Benzo(a)pyrene	164-166	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	65-93
14976333-12	2004	At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro.	Benzo(a)pyrene	164-166	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	95-98
15072824-8	2004	The high formation of BPDE-N(2)-dG adducts in bronchial epithelial cells and investigations showing that the profile of mutations induced by BPDE in these cells is similar to that seen in the p53 gene isolated from human lung tumors implicates benzo[a]pyrene as important carcinogen in tobacco-induced lung cancer in human beings.	Benzo(a)pyrene	244-258	tumor protein p53	Homo sapiens	192-195
17415813-18	2004	CONCLUSION: Vit C on its own and Se in combination with GSH represent strong endogenous inhibitors that can inhibit/reduce the carcinogenic action of BaP-induced carcinogenesis in wistar rats.	Benzo(a)pyrene	150-153	vitrin	Rattus norvegicus	12-15
15057875-1	2004	Transformation of the human breast epithelial cells (HBEC) MCF-10F with the carcinogen benz(a)pyrene (BP) into BP1-E cells resulted in the loss of the chromosome 17 p13.2 locus (D17S796 marker) and formation of colonies in agar-methocel (colony efficiency (CE)), loss of ductulogenic capacity in collagen matrix, and resistance to anti-Fas monoclonal antibody (Mab)-induced apoptosis.	Benzo(a)pyrene	102-104	BP1	Homo sapiens	111-114
15130436-0	2004	[Role of heat shock protein 70 expression in DNA damage induced by benzo(a)pyrene].	Benzo(a)pyrene	67-81	heat shock protein family A (Hsp70) member 4	Homo sapiens	9-30
15130436-1	2004	OBJECTIVE: To explore heat shock protein 70 (HSP70) expression of A549 cells and its role in DNA damage caused by benzo(a)pyrene (BaP).	Benzo(a)pyrene	114-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-43
15130436-1	2004	OBJECTIVE: To explore heat shock protein 70 (HSP70) expression of A549 cells and its role in DNA damage caused by benzo(a)pyrene (BaP).	Benzo(a)pyrene	114-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
15130436-1	2004	OBJECTIVE: To explore heat shock protein 70 (HSP70) expression of A549 cells and its role in DNA damage caused by benzo(a)pyrene (BaP).	Benzo(a)pyrene	130-133	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-43
15130436-1	2004	OBJECTIVE: To explore heat shock protein 70 (HSP70) expression of A549 cells and its role in DNA damage caused by benzo(a)pyrene (BaP).	Benzo(a)pyrene	130-133	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
15130436-4	2004	RESULTS: The integral optical densities of HSP70 in A549 cells treated with 1.25, 2.50, 5.00 and 10.00 micro mol/L BaP for 6 h (49.63 +/- 1.30, 45.72 +/- 1.03, 40.53 +/- 0.95, 37.50 +/- 1.20 respectively) were lower than that of the control cells (59.43 +/- 1.17) (P &lt; 0.05).	Benzo(a)pyrene	115-118	heat shock protein family A (Hsp70) member 4	Homo sapiens	43-48
15130436-5	2004	When A549 cells were exposed to 10 micro mol/L BaP for 4, 8, 12, 16 h, the integral optical densities of HSP70 were 33.33 +/- 0.80, 29.23 +/- 0.91, 12.51 +/- 0.96, 9.50 +/- 1.25 respectively, and there was an increasing tendency of the expression of HSP70 for 24 - 48 h (20.06 +/- 1.38, 24.51 +/- 1.39), however, all were different from that in control group (56.59 +/- 0.85) (P &lt; 0.05).	Benzo(a)pyrene	47-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	105-110
15130436-5	2004	When A549 cells were exposed to 10 micro mol/L BaP for 4, 8, 12, 16 h, the integral optical densities of HSP70 were 33.33 +/- 0.80, 29.23 +/- 0.91, 12.51 +/- 0.96, 9.50 +/- 1.25 respectively, and there was an increasing tendency of the expression of HSP70 for 24 - 48 h (20.06 +/- 1.38, 24.51 +/- 1.39), however, all were different from that in control group (56.59 +/- 0.85) (P &lt; 0.05).	Benzo(a)pyrene	47-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	250-255
15130436-8	2004	There was a negative correlation between DNA damage and the expression of HSP70 when A549 cells were exposed to different concentrations of BaP.	Benzo(a)pyrene	140-143	heat shock protein family A (Hsp70) member 4	Homo sapiens	74-79
15130436-9	2004	CONCLUSION: HSP70 might enhance intracellular defenses against DNA damage induced by BaP.	Benzo(a)pyrene	85-88	heat shock protein family A (Hsp70) member 4	Homo sapiens	12-17
15036119-10	2004	Multiple linear regression analysis showed that the increase in anti-BPDE-DNA adduct levels in LMF was significantly related to the high occupational exposure to PAHs (benzo[a]pyrene (BaP)) of coke-oven workers (t = 3.087, P &lt; 0.01) and to the lack of GSTM1 activity (t = 3.512, P &lt; 0.001), rather than to the two other confounding factors of PAH intake, i.e. charcoal-broiled meat consumption and smoking habits.	Benzo(a)pyrene	184-187	glutathione S-transferase mu 1	Homo sapiens	255-260
15061698-5	2004	Higher sensitivity of cells immortalized with RLV compared with the initial embryo cells to transforming effect of BP, which was described previously, is possibly associated with elevated expression of CYP1 isoforms.	Benzo(a)pyrene	115-117	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	202-206
14988465-4	2004	The level of RARbeta, a tumor suppressor, but not RARalpha or RARgamma, was reduced by 50% in the NHBE cells treated with BP.	Benzo(a)pyrene	122-124	retinoic acid receptor beta	Homo sapiens	13-20
14600278-4	2004	Over 200-fold interindividual variability was observed in both the glucuronidation and covalent binding of BP metabolites, with decreasing total glucuronidation among subjects correlating with a decreased UGT-modulated reduction in covalent binding (R(2) = 0.8272, p &lt; 0.01) and, in six subjects, enhanced cytotoxicity (r = -0.9338, p &lt; 0.001).	Benzo(a)pyrene	107-109	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	205-208
14600278-6	2004	These results provide the first evidence for substantial interindividual variability in UGT activities for BP metabolites among the normal population and suggest that UGT-deficient individuals may be at increased risk from the reactive intermediate-mediated effects of BP and related xenobiotics.	Benzo(a)pyrene	107-109	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	88-91
14600278-6	2004	These results provide the first evidence for substantial interindividual variability in UGT activities for BP metabolites among the normal population and suggest that UGT-deficient individuals may be at increased risk from the reactive intermediate-mediated effects of BP and related xenobiotics.	Benzo(a)pyrene	269-271	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	88-91
14729924-4	2004	In the presence of p55 the polymerase incorporated all four nucleotides and catalyzed limited translesion synthesis past BaP DE-dG adducts but not past BaP or BcPh DE-dA adducts.	Benzo(a)pyrene	121-124	DNA polymerase gamma 2, accessory subunit	Homo sapiens	19-22
14729368-7	2004	Lung S9 from various exposure groups was isolated from tissue homogenates and characterized for metabolic activity in activating 2-aminoanthracene (2-AA) and benzo[a]pyrene (BaP) mutagenicity using the Ames test with Salmonella typhimurium YG1024 and YG1029.	Benzo(a)pyrene	158-172	prohibitin 2	Rattus norvegicus	174-177
14729370-0	2004	Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes.	Benzo(a)pyrene	43-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-80
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	33-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	63-69
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	33-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	33-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	220-226
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	33-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	230-236
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	140-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	63-69
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	140-143	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	140-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	220-226
14729370-7	2004	With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2.	Benzo(a)pyrene	140-143	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	230-236
14520510-1	2004	The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benzo( a)pyrene (BaP) and pyrene (P).	Benzo(a)pyrene	146-161	prohibitin 2	Rattus norvegicus	175-178
14656999-6	2004	Besides, alpha-naphtoflavone (alpha-NF), an inhibitor of CYP1A1-mediated B(a)P metabolism, prevented all pH(i) changes, and NHE1 activation was blocked by the antioxidant thiourea, which inhibited CYP1A1 metabolism-dependent H2O2 production.	Benzo(a)pyrene	73-78	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	57-63
14656999-6	2004	Besides, alpha-naphtoflavone (alpha-NF), an inhibitor of CYP1A1-mediated B(a)P metabolism, prevented all pH(i) changes, and NHE1 activation was blocked by the antioxidant thiourea, which inhibited CYP1A1 metabolism-dependent H2O2 production.	Benzo(a)pyrene	73-78	solute carrier family 9 member A1	Rattus norvegicus	124-128
14743400-1	2004	Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting.	Benzo(a)pyrene	17-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
14743400-1	2004	Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting.	Benzo(a)pyrene	17-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	75-81
14743400-6	2004	Treatment with 4 microM B[a]P induced CYP1A1 expression in both normal and primary tumor prostate cells.	Benzo(a)pyrene	24-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-44
14691214-2	2004	Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon (PAH), can be bioactivated by cytochrome P-450s (CYPs) and epoxide hydrolase to genotoxic metabolites which form covalent adducts with DNA.	Benzo(a)pyrene	0-14	prohibitin 2	Rattus norvegicus	16-19
14729924-4	2004	In the presence of p55 the polymerase incorporated all four nucleotides and catalyzed limited translesion synthesis past BaP DE-dG adducts but not past BaP or BcPh DE-dA adducts.	Benzo(a)pyrene	152-155	DNA polymerase gamma 2, accessory subunit	Homo sapiens	19-22
14695324-0	2004	Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice.	Benzo(a)pyrene	46-60	apolipoprotein E	Mus musculus	132-136
14753257-9	2004	DHT-induced luciferase activity was reduced by bicalutamide and cyproterone acetate, AR antagonists, and also by benzo[a]pyrene, an aryl hydrocarbon receptor agonist, through AhR-mediated pathways.	Benzo(a)pyrene	113-127	aryl hydrocarbon receptor	Homo sapiens	132-157
14753257-9	2004	DHT-induced luciferase activity was reduced by bicalutamide and cyproterone acetate, AR antagonists, and also by benzo[a]pyrene, an aryl hydrocarbon receptor agonist, through AhR-mediated pathways.	Benzo(a)pyrene	113-127	aryl hydrocarbon receptor	Homo sapiens	175-178
15034205-1	2004	Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	97-122
15034205-1	2004	Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	124-127
15034205-1	2004	Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	97-122
15034205-1	2004	Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR).	Benzo(a)pyrene	16-21	aryl-hydrocarbon receptor	Mus musculus	124-127
14753754-0	2003	Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice.	Benzo(a)pyrene	0-14	apolipoprotein E	Mus musculus	74-90
14740720-6	2004	Inhalation risk associated with carcinogenic PAHs was estimated by using toxic equivalency factors based on the potency of benzo[a]pyrene (BaP).	Benzo(a)pyrene	123-137	prohibitin 2	Homo sapiens	139-142
14971036-5	2004	CD43, CD44, ICAM-3 and DC-SIGN, and signaling molecules PKD, Arp2/3 were found at the leading edge in MP or on both edges in BP cells, showing an intriguing parallelism between morphology and localization of molecular components on the poles of the motile DC.	Benzo(a)pyrene	125-127	sialophorin	Homo sapiens	0-4
14971036-5	2004	CD43, CD44, ICAM-3 and DC-SIGN, and signaling molecules PKD, Arp2/3 were found at the leading edge in MP or on both edges in BP cells, showing an intriguing parallelism between morphology and localization of molecular components on the poles of the motile DC.	Benzo(a)pyrene	125-127	protein kinase D1	Homo sapiens	56-59
14971036-5	2004	CD43, CD44, ICAM-3 and DC-SIGN, and signaling molecules PKD, Arp2/3 were found at the leading edge in MP or on both edges in BP cells, showing an intriguing parallelism between morphology and localization of molecular components on the poles of the motile DC.	Benzo(a)pyrene	125-127	actin related protein 2	Homo sapiens	61-65
14684671-9	2004	These results show that in carriers of the 460Trp ADD1 allele (38% of the population), the administration of diuretics halves the incidence of myocardial infarction and stroke when compared with other antihypertensive treatments that produce similar reduction of BP.	Benzo(a)pyrene	263-265	adducin 1	Homo sapiens	50-54
14870984-4	2004	An IgG passive transfer mouse model of BP was developed by administering rabbit antimurine BP180 antibodies to neonatal mice.	Benzo(a)pyrene	39-41	collagen, type XVII, alpha 1	Mus musculus	91-96
15029263-2	2004	Twelve representative sera of BP were tested against the RSILPYGDSMDRIEKDRLQMAP amino acid sequence that is an epitope fragment of the NC16A domain of BPAG2 (AC Q02802; 507-528) to find the most suitable antigenic form for specific detection of autoantibodies of BP patients" sera by quantitative ELISA system.	Benzo(a)pyrene	30-32	collagen type XVII alpha 1 chain	Homo sapiens	151-156
15098469-11	2004	In the low dose BaP group, HSP70 level were much higher than that of control groups.	Benzo(a)pyrene	16-19	heat shock protein 1B	Mus musculus	27-32
14617069-7	2003	In stm mutants, ectopic expression of CUC1 could not induce adventitious SAMs, whereas they continued to be observed in bp mutants.	Benzo(a)pyrene	120-122	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	38-42
12970582-2	2003	In these studies, we have focused on two known skin carcinogens, arsenic and benzo(a)pyrene (BaP).	Benzo(a)pyrene	77-91	prohibitin 2	Homo sapiens	93-96
14520703-9	2003	There was some indication of weaker associations between K-ras mutations and occupational exposure to lead, PAHs, benzo[a]pyrene, gasoline, nickel, inhalatory exposure to chromium and sedentary work.	Benzo(a)pyrene	114-128	KRAS proto-oncogene, GTPase	Homo sapiens	57-62
14613719-0	2003	Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver.	Benzo(a)pyrene	28-42	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	59-65
14613719-0	2003	Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver.	Benzo(a)pyrene	28-42	aryl-hydrocarbon receptor	Mus musculus	87-98
14613719-0	2003	Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver.	Benzo(a)pyrene	28-42	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	121-127
14613719-2	2003	Benzo(a)pyrene (BP), a much more potent Ah receptor ligand, shows very different responses that nevertheless depend on CYP1B1.	Benzo(a)pyrene	0-14	aryl-hydrocarbon receptor	Mus musculus	40-51
14613719-2	2003	Benzo(a)pyrene (BP), a much more potent Ah receptor ligand, shows very different responses that nevertheless depend on CYP1B1.	Benzo(a)pyrene	0-14	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	119-125
14613719-2	2003	Benzo(a)pyrene (BP), a much more potent Ah receptor ligand, shows very different responses that nevertheless depend on CYP1B1.	Benzo(a)pyrene	16-18	aryl-hydrocarbon receptor	Mus musculus	40-51
14613719-2	2003	Benzo(a)pyrene (BP), a much more potent Ah receptor ligand, shows very different responses that nevertheless depend on CYP1B1.	Benzo(a)pyrene	16-18	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	119-125
14613719-4	2003	In congenic mice with a low affinity AhR (AhR(d)), DMBA and BP are equally toxic to the BM whereas AhR(d) x CYP1B1-null mice are fully protected.	Benzo(a)pyrene	60-62	aryl-hydrocarbon receptor	Mus musculus	37-40
14613719-4	2003	In congenic mice with a low affinity AhR (AhR(d)), DMBA and BP are equally toxic to the BM whereas AhR(d) x CYP1B1-null mice are fully protected.	Benzo(a)pyrene	60-62	aryl-hydrocarbon receptor	Mus musculus	42-48
14613719-7	2003	In wild-type mice, BP treatment leads to a fivefold greater induction of hepatic CYP1A1 than that of DMBA treatment.	Benzo(a)pyrene	19-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	81-87
14613719-9	2003	Thus, hepatic metabolism may prevent BP from reaching the BM, where it can be bioactivated by CYP1B1.	Benzo(a)pyrene	37-39	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	94-100
14616870-7	2003	RESULTS: IL-4 induced CD23 expression on B cells and on monocytes and sCD23 release in the bp-allergic and non-bp-allergic groups.	Benzo(a)pyrene	91-93	interleukin 4	Homo sapiens	9-13
14616870-7	2003	RESULTS: IL-4 induced CD23 expression on B cells and on monocytes and sCD23 release in the bp-allergic and non-bp-allergic groups.	Benzo(a)pyrene	111-113	interleukin 4	Homo sapiens	9-13
14616870-9	2003	CD23 expression on monocytes was also decreased in both groups after the addition of BPA, but higher doses were required in the non-bp-allergic population.	Benzo(a)pyrene	132-134	Fc epsilon receptor II	Homo sapiens	0-4
14616870-11	2003	IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups.	Benzo(a)pyrene	52-54	interferon gamma	Homo sapiens	0-9
14616870-11	2003	IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups.	Benzo(a)pyrene	52-54	interleukin 10	Homo sapiens	14-19
14616870-11	2003	IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups.	Benzo(a)pyrene	72-74	interferon gamma	Homo sapiens	0-9
14616870-11	2003	IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups.	Benzo(a)pyrene	72-74	interleukin 10	Homo sapiens	14-19
14644313-10	2003	Thus, for benzo(a)pyrene (at 10-50 adducts per 10(8) nucleotides) repair was essentially complete within 1 day in p53(+/+) human fibroblasts while no repair was detected within 3 days in p53(-/-) cells.	Benzo(a)pyrene	10-24	tumor protein p53	Homo sapiens	114-117
14644313-10	2003	Thus, for benzo(a)pyrene (at 10-50 adducts per 10(8) nucleotides) repair was essentially complete within 1 day in p53(+/+) human fibroblasts while no repair was detected within 3 days in p53(-/-) cells.	Benzo(a)pyrene	10-24	tumor protein p53	Homo sapiens	187-190