PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16441880-5	2006	RESULTS: Tat Oyi with Montanide or Calcium Phosphate gave rabbit sera able to recognize all Tat variants.	calcium phosphate	35-52	LOW QUALITY PROTEIN: tyrosine aminotransferase	Oryctolagus cuniculus	92-95
16418779-14	2006	Monoclonal Ab blockade of TREM2 on OCs generated from C57BL/6 BMMs results in decreased resorption of artificial calcium-phosphate substrate and dentine.	calcium phosphate	113-130	triggering receptor expressed on myeloid cells 2	Homo sapiens	26-31
16391260-1	2006	BACKGROUND: While recombinant human bone morphogenetic protein-2 (rhBMP-2) administered in a calcium phosphate cement accelerates osteotomy-site healing in animal models when administered three hours after surgery, definitive fracture treatment is often delayed.	calcium phosphate	93-110	bone morphogenetic protein 2	Homo sapiens	36-64
17722263-6	2006	Lastly, this study showed that the directed osteoblast adhesion on CNF patterns translated to enhanced calcium phosphate mineral deposition along linear patterns of CNFs on PCU.	calcium phosphate	103-120	NPHS1 adhesion molecule, nephrin	Homo sapiens	67-70
16088901-8	2005	From the literature, proteoglycans, pyrophosphates, phospholipids, lubricin, and superficial zone protein (SZP) have been identified as possible causes for the insignificant deposit of calcium phosphate from synovial fluid.	calcium phosphate	185-202	proteoglycan 4	Homo sapiens	107-110
16423183-7	2006	In uremic patients, apart from these facilitating factors, decreased levels of endogenous calcification inhibitors such as fetuin-Amatrix Gla protein, osteoprotegerin, and osteopontin have also been associated with increased calcium-phosphate precipitation in extraskeletal tissues.	calcium phosphate	225-242	TNF receptor superfamily member 11b	Homo sapiens	151-166
16423183-7	2006	In uremic patients, apart from these facilitating factors, decreased levels of endogenous calcification inhibitors such as fetuin-Amatrix Gla protein, osteoprotegerin, and osteopontin have also been associated with increased calcium-phosphate precipitation in extraskeletal tissues.	calcium phosphate	225-242	secreted phosphoprotein 1	Homo sapiens	172-183
16331974-0	2005	Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution.	calcium phosphate	135-152	dentin matrix acidic phosphoprotein 1	Homo sapiens	107-130
16331974-5	2005	In this study, we have demonstrated using synchrotron small-angle X-ray scattering that DMP1 in solution can undergo oligomerization and temporarily stabilize the newly formed calcium phosphate nanoparticle precursors by sequestering them and preventing their further aggregation and precipitation.	calcium phosphate	176-193	dentin matrix acidic phosphoprotein 1	Homo sapiens	88-92
16331974-7	2005	Atomic force microscopy and transmission electron microscopy studies further confirmed that the nascent calcium phosphate nuclei formed in solution were assembled into ordered protein-mineral complexes with the aid of oligomerized DMP1, recombinant and native.	calcium phosphate	104-121	dentin matrix acidic phosphoprotein 1	Homo sapiens	231-235
16331974-8	2005	This study reveals a novel mechanism by which DMP1 might facilitate initiation of mineral nucleation at specific sites during bone and dentin mineralization and prevent spontaneous calcium phosphate precipitation in areas in which mineralization is not desirable.	calcium phosphate	181-198	dentin matrix acidic phosphoprotein 1	Homo sapiens	46-50
16153224-5	2005	After transfecting the fusion gene into T24 cells by the method of calcium phosphate-DNA co-precipitation, we detected steady expression of the GFP-hTERT fusion protein by fluorescent-light microscopy.	calcium phosphate	67-84	telomerase reverse transcriptase	Homo sapiens	148-153
16323043-0	2005	Colloidal calcium phosphate in the reconstituted milk micelle may direct wild-type recombinant human beta-casein to fold like the native protein.	calcium phosphate	10-27	casein beta	Homo sapiens	101-112
15972241-1	2005	The release kinetics of recombinant human bone morphogenetic protein-2 (rhBMP-2) loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement (PLGA/Ca-P cement) composites were studied in vivo.	calcium phosphate	121-138	bone morphogenetic protein 2	Homo sapiens	42-70
16087232-2	2005	While the steady-state cycling of Ca2+ across the inner membrane between independent uptake and efflux pathways seems at first sight to be symmetrical, the distinctive kinetics of the uniporter, which is highly dependent on external free Ca2+ concentration and the efflux pathway, whose activity is clamped over a wide range of total matrix Ca2+ by the solubility of the calcium phosphate complex provide a mechanism whereby mitochondria reversibly sequester transient elevations in cytoplasmic Ca2+.	calcium phosphate	371-388	carbonic anhydrase 2	Homo sapiens	34-37
15965592-9	2005	This is attributed to the formation of viscous polymer solution coatings on the calcium phosphate precursors, retarding their reaction, and consequently inhibiting SHAp formation.	calcium phosphate	80-97	shroom family member 4	Homo sapiens	164-168
16007483-7	2005	The mOPN stabilized the conversion of amorphous calcium phosphate (a non-crystalline constituent of milk) to HA, whereas bone OPN had a lesser effect on this conversion.	calcium phosphate	48-65	secreted phosphoprotein 1	Mus musculus	4-8
16007483-7	2005	The mOPN stabilized the conversion of amorphous calcium phosphate (a non-crystalline constituent of milk) to HA, whereas bone OPN had a lesser effect on this conversion.	calcium phosphate	48-65	secreted phosphoprotein 1	Homo sapiens	5-8
15892946-3	2005	The proposed function of those that are multiphosphorylated is: (i) the stabilisation of calcium phosphate in solution (e.g. casein, statherin) preventing spontaneous precipitation and seeded-crystal growth or (ii) promoting biomineralisation (e.g. the phosphophoryn domain of DSPP), where the protein described as a template macromolecule, is proposed to act as a nucleator/promoter of crystal growth.	calcium phosphate	89-106	statherin	Homo sapiens	133-142
15892946-3	2005	The proposed function of those that are multiphosphorylated is: (i) the stabilisation of calcium phosphate in solution (e.g. casein, statherin) preventing spontaneous precipitation and seeded-crystal growth or (ii) promoting biomineralisation (e.g. the phosphophoryn domain of DSPP), where the protein described as a template macromolecule, is proposed to act as a nucleator/promoter of crystal growth.	calcium phosphate	89-106	dentin sialophosphoprotein	Homo sapiens	277-281
15755756-1	2005	BACKGROUND: Our earlier studies have demonstrated upregulation of monocyte chemoattractant protein-1 (MCP-1) in NRK52E rat renal epithelial cells by exposure to oxalate (Ox) ions and crystals of calcium oxalate monohydrate (COM) or the brushite (Br) form of calcium phosphate.	calcium phosphate	258-275	chemokine (C-C motif) ligand 2	Mus musculus	66-100
16180337-4	2005	The UCP1 gene was transferred into the hepatic cells by using a calcium phosphate precipitation protocol.	calcium phosphate	64-81	uncoupling protein 1	Homo sapiens	4-8
15576140-5	2005	The use of the ATR-liquid cell allowed the observation of the reaction in real time, and this showed that the process of silica formation is not separable from cation leaching from the glass, as well as the formation of the calcium phosphate rich layer.	calcium phosphate	224-241	ATR serine/threonine kinase	Homo sapiens	15-18
15576172-11	2005	Osteoblast phenotype expression (ALP activity) was observed to be highest in calcium phosphate deposited samples, emphasizing the effect of mineralization on osteoblast differentiation.	calcium phosphate	77-94	PDZ and LIM domain 3	Rattus norvegicus	33-36
15814303-12	2005	CONCLUSION: BMP-2 incorporated into biomimetic calcium phosphate coatings is capable not only of inducing bone formation at an ectopic site in vivo but also of doing so with a very high potency at a low pharmacological level, and of sustaining this activity for a considerable period of time.	calcium phosphate	47-64	bone morphogenetic protein 2	Rattus norvegicus	12-17
16851965-4	2005	Time-resolved static light scattering measurements revealed that the transformation from ACP to HAP was inhibited when free phosvitin was present in the calcium phosphate solutions.	calcium phosphate	153-170	casein kinase 2 beta	Homo sapiens	124-133
15755756-1	2005	BACKGROUND: Our earlier studies have demonstrated upregulation of monocyte chemoattractant protein-1 (MCP-1) in NRK52E rat renal epithelial cells by exposure to oxalate (Ox) ions and crystals of calcium oxalate monohydrate (COM) or the brushite (Br) form of calcium phosphate.	calcium phosphate	258-275	chemokine (C-C motif) ligand 2	Mus musculus	102-107
15831823-6	2005	Osteopontin, however, appears to block vascular calcification most likely by preventing calcium phosphate crystal growth and inducing cellular mineral resorption.	calcium phosphate	88-105	secreted phosphoprotein 1	Homo sapiens	0-11
15807558-1	2005	Nanocrystalline calcium phosphate based inorganic, hydroxyapatite (HAp), was synthesized using the dodecyl phosphate micelle system.	calcium phosphate	16-33	reticulon 3	Homo sapiens	67-70
16161929-5	2005	Reduction of PTH concentration protects bones from further destruction and from accumulation of calcium phosphate in tissues.	calcium phosphate	96-113	parathyroid hormone	Homo sapiens	13-16
15707938-3	2005	Given that the opportunities for cell to cell adhesion could be altered due to the presence of the DNA-containing complexes, we examined the effect of the calcium-phosphate transfection procedure upon Stat3 activity levels.	calcium phosphate	155-172	signal transducer and activator of transcription 3	Homo sapiens	201-206
15707938-4	2005	The results revealed a dramatic increase in Stat3 phosphorylation at the critical tyr705 site and Stat3 activity following calcium-phosphate transfection.	calcium phosphate	123-140	signal transducer and activator of transcription 3	Homo sapiens	44-49
15707938-4	2005	The results revealed a dramatic increase in Stat3 phosphorylation at the critical tyr705 site and Stat3 activity following calcium-phosphate transfection.	calcium phosphate	123-140	signal transducer and activator of transcription 3	Homo sapiens	98-103
15744619-12	2005	Moreover, alkaline phosphatase (ALP) activity was higher in the supernatants collected from the pre-mineralized samples, when compared to the control samples (non Ca-P coated).	calcium phosphate	163-167	alkaline phosphatase, placental	Homo sapiens	10-30
15725522-3	2005	The proline-rich proteins, statherin and the histatins are salivary proteins that influence calcium phosphate chemistry, initial plaque formation and candida infection.	calcium phosphate	92-109	statherin	Homo sapiens	27-36
15744619-12	2005	Moreover, alkaline phosphatase (ALP) activity was higher in the supernatants collected from the pre-mineralized samples, when compared to the control samples (non Ca-P coated).	calcium phosphate	163-167	alkaline phosphatase, placental	Homo sapiens	32-35
15842805-2	2005	METHODS: Smad 2 vector was transfected into MsC by calcium phosphate.	calcium phosphate	51-68	SMAD family member 2	Rattus norvegicus	9-15
15625683-1	2005	Hydroxyapatite/soluble calcium phosphate composites (HAp/SCaP) are novel HAp-based materials with enhanced solubility that have been developed by annealing HAp in a vacuum.	calcium phosphate	23-40	scaffold attachment factor B	Mus musculus	53-56
15625683-1	2005	Hydroxyapatite/soluble calcium phosphate composites (HAp/SCaP) are novel HAp-based materials with enhanced solubility that have been developed by annealing HAp in a vacuum.	calcium phosphate	23-40	SREBF chaperone	Mus musculus	57-61
15625683-1	2005	Hydroxyapatite/soluble calcium phosphate composites (HAp/SCaP) are novel HAp-based materials with enhanced solubility that have been developed by annealing HAp in a vacuum.	calcium phosphate	23-40	scaffold attachment factor B	Mus musculus	73-76
15625683-1	2005	Hydroxyapatite/soluble calcium phosphate composites (HAp/SCaP) are novel HAp-based materials with enhanced solubility that have been developed by annealing HAp in a vacuum.	calcium phosphate	23-40	scaffold attachment factor B	Mus musculus	73-76
15592877-1	2005	Alpha2-HS glycoprotein (AHSG), also known as fetuin-A, is a plasma protein displaying high-affinity interaction with calcium phosphate, by which ectopic vascular calcification is prevented.	calcium phosphate	117-134	alpha 2-HS glycoprotein	Homo sapiens	0-22
15592877-1	2005	Alpha2-HS glycoprotein (AHSG), also known as fetuin-A, is a plasma protein displaying high-affinity interaction with calcium phosphate, by which ectopic vascular calcification is prevented.	calcium phosphate	117-134	alpha 2-HS glycoprotein	Homo sapiens	24-28
15592877-1	2005	Alpha2-HS glycoprotein (AHSG), also known as fetuin-A, is a plasma protein displaying high-affinity interaction with calcium phosphate, by which ectopic vascular calcification is prevented.	calcium phosphate	117-134	alpha 2-HS glycoprotein	Homo sapiens	45-53
16277673-9	2005	We also demonstrate that, in addition to its effect on cell infiltration, CXCL12 potentiates receptor activator of NF-kappaB ligand-induced osteoclast differentiation from splenocytes and increases the calcium phosphate-resorbing capacity of these osteoclasts, both processes being potently counteracted by AMD3100.	calcium phosphate	202-219	chemokine (C-X-C motif) ligand 12	Mus musculus	74-80
15642196-4	2005	rAAV.DCN, containing high titer of DCN, was produced by transfecting into 293 cells with calcium phosphate-DNA sedimentation method, and transfected into SiHa cells, rAAV.LacZ-infected cells and non-infected cells were used as controls.	calcium phosphate	89-106	decorin	Homo sapiens	5-8
15659118-2	2005	METHODS: Full-length cDNA encoding alpha1B-AR was transfected into HEK293 cells using the calcium phosphate precipitation method, and alpha1B-AR expression and cAMP accumulation were determined by using the saturation radioligand binding assay and ion-exchange chromatography, respectively.	calcium phosphate	90-107	adrenoceptor alpha 1B	Homo sapiens	35-45
15776728-4	2005	Furthermore, the lack of inhibitory proteins, such as fetuin and matrix Gla protein, is a possible main determinant of calcium-phosphate deposition in soft tissues.	calcium phosphate	119-136	matrix Gla protein	Homo sapiens	65-83
15635550-0	2005	Clinical applications of Norian SRS (calcium phosphate cement) in craniofacial reconstruction in children: our experience at Hospital La Paz since 2001.	calcium phosphate	37-54	Russell-Silver dwarfism	Homo sapiens	32-35
15635550-4	2005	MATERIALS AND METHODS: We report our experience at the Pediatric Division of Maxillofacial Surgery Department, Hospital La Paz, Madrid, since 2001, in the use of Norian SRS (calcium phosphate cement; Norian, Cupertino, CA) for the treatment of secondary craniofacial deformities.	calcium phosphate	174-191	Russell-Silver dwarfism	Homo sapiens	169-172
15519583-0	2004	Fibronectin in collaboration with Mg2+ enhances transgene expression by calcium phosphate coprecipitates.	calcium phosphate	72-89	fibronectin 1	Homo sapiens	0-11
15665555-5	2005	DESIGN: We transfected a full-length human HGF cDNA in an expression vector into human peritoneal mesothelial cells (HPMCs) using the calcium phosphate method.	calcium phosphate	134-151	hepatocyte growth factor	Homo sapiens	43-46
15533136-0	2004	The use of porous calcium phosphate scaffolds with transforming growth factor beta 1 as an onlay bone graft substitute.	calcium phosphate	18-35	transforming growth factor, beta 1	Rattus norvegicus	51-84
16103720-0	2005	A high calcium-phosphate product is associated with high C-reactive protein concentrations in hemodialysis patients.	calcium phosphate	7-24	C-reactive protein	Homo sapiens	57-75
15342759-0	2004	Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model.	calcium phosphate	74-91	bone morphogenetic protein 2	Homo sapiens	18-46
15363596-6	2004	RANKL-stimulated RAW264.7-ERalpha cells formed resorption pits on calcium phosphate films and the pit formation was inhibited by coumestrol in a dose-dependent manner.	calcium phosphate	66-83	TNF superfamily member 11	Homo sapiens	0-5
15130724-1	2004	A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4V surface.	calcium phosphate	42-59	albumin	Homo sapiens	9-22
15483782-10	2004	Serum phosphate showed a trend to decrease in the intervention group, whereas the serum calcium-phosphate product decreased significantly (from 66.8 +/- 13.1 to 61.0 +/- 13.8 mg2 /dL2 , P < .05).	calcium phosphate	88-105	mucin 7, secreted	Homo sapiens	175-178
15483782-10	2004	Serum phosphate showed a trend to decrease in the intervention group, whereas the serum calcium-phosphate product decreased significantly (from 66.8 +/- 13.1 to 61.0 +/- 13.8 mg2 /dL2 , P < .05).	calcium phosphate	88-105	l(1)L2	Drosophila melanogaster	180-183
15293315-2	2004	In previous work, some of the authors found that bovine serum albumin (BSA) promotes calcium phosphate deposition if preadsorbed on hydroxyapatite and retards precipitation if preadsorbed on titania.	calcium phosphate	85-102	albumin	Homo sapiens	56-69
15605716-6	2004	Removal of colloidal calcium phosphate from milk also reduced HP-induced denaturation of alpha-la and beta-lg significantly.	calcium phosphate	21-38	lactalbumin alpha	Bos taurus	89-97
15605716-6	2004	Removal of colloidal calcium phosphate from milk also reduced HP-induced denaturation of alpha-la and beta-lg significantly.	calcium phosphate	21-38	beta-lactoglobulin	Bos taurus	102-109
15605716-7	2004	The higher level of HP-induced denaturation of alpha-la and beta-lg in milk than in whey may be the result of the abscence of the casein micelles and colloidal calcium phosphate from whey, which facilitate HP-induced denaturation of alpha-la and beta-lg in milk.	calcium phosphate	160-177	lactalbumin alpha	Bos taurus	47-55
15605716-7	2004	The higher level of HP-induced denaturation of alpha-la and beta-lg in milk than in whey may be the result of the abscence of the casein micelles and colloidal calcium phosphate from whey, which facilitate HP-induced denaturation of alpha-la and beta-lg in milk.	calcium phosphate	160-177	beta-lactoglobulin	Bos taurus	60-67
15121013-3	2004	Release of Wnt3A or lithium from porous calcium phosphate scaffolds, which we use for bone tissue engineering, could provide a mitogenic stimulus to implanted hMSCs.	calcium phosphate	40-57	Wnt family member 3A	Homo sapiens	11-16
15640852-4	2004	After introducing the plasmids into hepatocellular carcinoma cell line (Huh7) by calcium phosphate transfection, the culture supernatant was collected to detect HBsAg and HBV DNA to analyze viral replication and expression.	calcium phosphate	81-98	MIR7-3 host gene	Homo sapiens	72-76
15284362-9	2004	Decreased serum fetuin-A has been shown to be associated with a reduced capacity to inhibit calcium phosphate precipitation in vitro and is predictive of mortality in dialysis patients.	calcium phosphate	92-109	alpha 2-HS glycoprotein	Homo sapiens	16-24
15252089-0	2004	Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomy.	calcium phosphate	78-95	bone morphogenetic protein 2	Homo sapiens	44-72
15252089-1	2004	BACKGROUND: In this study, we evaluated the capacity of a single percutaneous injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered in a rapidly resorbable calcium phosphate paste (alpha-BSM) to accelerate bone-healing in a canine tibial osteotomy model.	calcium phosphate	182-199	bone morphogenetic protein 2	Homo sapiens	109-137
15158917-0	2004	Calcium phosphate and calcium oxalate crystal handling is dependent upon CLC-5 expression in mouse collecting duct cells.	calcium phosphate	0-17	chloride channel, voltage-sensitive 5	Mus musculus	73-78
15158917-4	2004	Binding of both calcium phosphate (hydroxyapatite) and calcium oxalate monohydrate (COM) crystals overlaid onto mIMCD-3 cultures was affected by altered CLC-5 expression.	calcium phosphate	16-33	chloride channel, voltage-sensitive 5	Mus musculus	153-158
15158917-5	2004	Calcium phosphate crystal agglomerations (>10 microm) were minimal in control (9%) and sense (13%) CLC-5-transfected cells, compared to 66% of antisense CLC-5-transfected cells (P<0.001).	calcium phosphate	0-17	chloride channel, voltage-sensitive 5	Mus musculus	102-107
15158917-6	2004	Small calcium phosphate crystals (<10 microm) were found associated with 45% of sense CLC-5-treated cells, of which the majority (11/14 cells) appeared to be internalised within the cell.	calcium phosphate	6-23	chloride channel, voltage-sensitive 5	Mus musculus	89-94
15121013-10	2004	In future studies, we will try to limit release of lithium or Wnt3A from calcium phosphate scaffolds to the proliferative phase of osteogenesis.	calcium phosphate	73-90	Wnt family member 3A	Homo sapiens	62-67
15086938-9	2004	Our results may provide new insights into the pathophysiologic effects of FGF-23 on calcium-phosphate homeostasis.	calcium phosphate	84-101	fibroblast growth factor 23	Homo sapiens	74-80
15030529-1	2004	The ability of calcium phosphate (CaP) and calcium pyrophosphate (CaPPi) to mediate matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) binding to fibrin was evaluated.	calcium phosphate	15-32	matrix metallopeptidase 2	Homo sapiens	84-117
15030529-1	2004	The ability of calcium phosphate (CaP) and calcium pyrophosphate (CaPPi) to mediate matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) binding to fibrin was evaluated.	calcium phosphate	15-32	matrix metallopeptidase 2	Homo sapiens	119-124
15030529-1	2004	The ability of calcium phosphate (CaP) and calcium pyrophosphate (CaPPi) to mediate matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) binding to fibrin was evaluated.	calcium phosphate	15-32	matrix metallopeptidase 9	Homo sapiens	129-134
15030529-1	2004	The ability of calcium phosphate (CaP) and calcium pyrophosphate (CaPPi) to mediate matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) binding to fibrin was evaluated.	calcium phosphate	34-37	matrix metallopeptidase 2	Homo sapiens	119-124
14762932-9	2004	All the calcium phosphate-coated-ZrO(2) scaffolds showed higher ALP levels compared to pure ZrO(2) scaffold.	calcium phosphate	8-25	alkaline phosphatase, placental	Homo sapiens	64-67
15115769-3	2004	PGIS was expressed in the microsomes of the infected Sf21 cells after culture in 5 microg/ml hematin-supplemented medium for 72 h. The holoenzyme was isolated from the solubilized microsomal fraction by calcium phosphate gel absorption and purified to homogeneity by DEAE-Sepharose and hydroxyapatite column chromatography.	calcium phosphate	203-220	prostaglandin I2 synthase	Homo sapiens	0-4
15041047-0	2004	Localization of osteopontin at calcification sites of cholesteatoma: possible role as a regulator of deposition of calcium phosphate in the middle ear.	calcium phosphate	115-132	secreted phosphoprotein 1	Homo sapiens	16-27
15041047-14	2004	Therefore, it is suggested the possibility that OPN might contribute as a common regulator of the deposition of calcium phosphate in the middle ear.	calcium phosphate	112-129	secreted phosphoprotein 1	Homo sapiens	48-51
15152817-8	2004	Finally, the effects of TRK-530 on the precipitation of calcium-phosphate from solution were tested in vitro.	calcium phosphate	56-73	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	24-27
15152817-12	2004	TRK-530 inhibited the precipitation of calcium-phosphate from solution in vitro.	calcium phosphate	39-56	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	0-3
14762934-0	2004	Transforming growth factor-beta1 accelerates bone bonding to a blended calcium phosphate ceramic coating: a dose-response study.	calcium phosphate	71-88	transforming growth factor beta-1 proprotein	Canis lupus familiaris	0-32
15468286-0	2004	Association of calcium phosphate and fibroblast growth factor-2: a dynamic light scattering study.	calcium phosphate	15-32	fibroblast growth factor 2	Homo sapiens	37-63
15191724-5	2004	In addition, human IL-1R-II cDNA was subcloned into retrovirus vector LZRSPBMN and transfected into 293 cells by calcium phosphate precipitation.	calcium phosphate	113-130	interleukin 1 receptor type 2	Homo sapiens	19-27
15468286-7	2004	These FGF-2 solutions were mixed with calcium phosphate solutions to produce a sub-micron sized compound of FGF-2 and hydroxyapatite, which could be used as a biological implant that possessed a pharmacological function for bone formation.	calcium phosphate	38-55	fibroblast growth factor 2	Homo sapiens	108-113
15468286-8	2004	By utilizing a transformation from amorphous calcium phosphate to hydroxyapatite, FGF-2 was effectively incorporated into polycrystals of hydroxyapatite.SEM photograph of a mixture of hydroxyapatite and FGF-2.	calcium phosphate	45-62	fibroblast growth factor 2	Homo sapiens	82-87
12887401-4	2003	The effect of RANKL on root resorbing activity of odontoclasts was evaluated by measuring the size of dissolved area on calcium phosphate-coated coverslips.	calcium phosphate	120-137	TNF superfamily member 11	Homo sapiens	14-19
14614593-4	2003	Kv1.5 cDNA in pcDNA3 expression vector and CD8, a surface marker protein, were cotransfected in cells by calcium phosphate precipitation.	calcium phosphate	105-122	potassium voltage-gated channel subfamily A member 5	Homo sapiens	0-5
14600836-5	2003	By contrast, CXCL10 and CXCL12 were strongly upregulated from day 0 to day 8 in cells grown on calcium phosphate-coated slides.	calcium phosphate	95-112	C-X-C motif chemokine ligand 10	Homo sapiens	13-19
14600836-5	2003	By contrast, CXCL10 and CXCL12 were strongly upregulated from day 0 to day 8 in cells grown on calcium phosphate-coated slides.	calcium phosphate	95-112	C-X-C motif chemokine ligand 12	Homo sapiens	24-30
14600836-7	2003	Interestingly, both at molecular and protein levels CXCL10 and CXCL12 significantly increased only when cells were differentiated on calcium phosphate-coated slides.	calcium phosphate	133-150	C-X-C motif chemokine ligand 10	Homo sapiens	52-58
14600836-7	2003	Interestingly, both at molecular and protein levels CXCL10 and CXCL12 significantly increased only when cells were differentiated on calcium phosphate-coated slides.	calcium phosphate	133-150	C-X-C motif chemokine ligand 12	Homo sapiens	63-69
15182620-2	2004	METHODS: Expression plasmid P1A/pSMART2a and packaging plasmid helper were cotransfected into mammalian 293 cells by calcium phosphate precipitation method and high level of recombinant alpha-virus P1A/SFV was prepared.	calcium phosphate	117-134	zinc finger protein 185 with LIM domain	Homo sapiens	28-31
12734825-1	2003	Calcium phosphate granules were produced through the calcination of three hydroxyapatites (HAs) at 1150 degrees C: nearly-stoichiometric (NS-HA), calcium-deficient (CD-HA), and carbonated (Carb-HA).	calcium phosphate	0-17	syntaxin 8	Homo sapiens	189-193
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	calcium phosphate	229-246	interleukin 1 beta	Homo sapiens	38-55
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	calcium phosphate	229-246	interleukin 1 beta	Homo sapiens	57-65
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	calcium phosphate	229-246	matrix metallopeptidase 1	Homo sapiens	88-93
14599991-2	2003	METHODS: A recombinant and replication-deficient type-5 adenovirus encoding murine FasL (AdV- FasL) was constructed by the method of calcium phosphate precipitation.	calcium phosphate	133-150	Fas ligand (TNF superfamily, member 6)	Mus musculus	83-87
14599991-2	2003	METHODS: A recombinant and replication-deficient type-5 adenovirus encoding murine FasL (AdV- FasL) was constructed by the method of calcium phosphate precipitation.	calcium phosphate	133-150	Fas ligand (TNF superfamily, member 6)	Mus musculus	94-98
15348487-1	2003	Physical, chemical and biological properties of calcium phosphate coatings fabricated by a pulse laser deposition method at room temperature (RT PLD) have been studied.	calcium phosphate	48-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	145-148
12731090-2	2003	In the present study, we examined the effect of calcium phosphate (CaPi) on recombinant adeno-associated virus (rAAV)-mediated insulin therapy in diabetic animals.	calcium phosphate	48-65	insulin	Homo sapiens	127-134
12731090-10	2003	Results obtained from both RIA and immunohistochemical staining demonstrated that incorporation of calcium phosphate enhanced rAAV-mediated gene transfer in vivo, leading to higher expression and secretion of human insulin.	calcium phosphate	99-116	insulin	Homo sapiens	215-222
12822344-1	2003	OBJECTIVE: To investigate and compare the osteogenic potential of three kinds of calcium phosphate ceramic as carriers for recombinant human bone morphogenetic protein-2(rhBMP-2) in vivo.	calcium phosphate	81-98	bone morphogenetic protein 2	Homo sapiens	141-169
12637633-3	2003	We investigated the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein by NRK52E rat renal tubular epithelial cells exposed to calcium oxalate (CaOx), brushite (Br, a calcium phosphate) and uric acid (UA) crystals.	calcium phosphate	190-207	C-C motif chemokine ligand 2	Rattus norvegicus	34-68
12637633-10	2003	CONCLUSION: Exposure to both CaOx and calcium phosphate crystals stimulates increased production of MCP-1.	calcium phosphate	38-55	C-C motif chemokine ligand 2	Rattus norvegicus	100-105
12740096-6	2003	The addition of calcium phosphate glass as in HC3 scaffolds increased the ALP and OC levels of MG63 cells.	calcium phosphate	16-33	CYCS pseudogene 24	Homo sapiens	46-49
12740096-6	2003	The addition of calcium phosphate glass as in HC3 scaffolds increased the ALP and OC levels of MG63 cells.	calcium phosphate	16-33	alkaline phosphatase, placental	Homo sapiens	74-77
12483712-4	2003	PMMA had a negative effect on osteoblasts, whereas PMMA+alpha-TCP enhanced production of ALP, PICP, OC and TGFbeta-1, and reduced IL-6 levels.	calcium phosphate	56-65	ATHS	Homo sapiens	89-92
12483712-4	2003	PMMA had a negative effect on osteoblasts, whereas PMMA+alpha-TCP enhanced production of ALP, PICP, OC and TGFbeta-1, and reduced IL-6 levels.	calcium phosphate	56-65	transforming growth factor beta 1	Homo sapiens	107-116
12483712-4	2003	PMMA had a negative effect on osteoblasts, whereas PMMA+alpha-TCP enhanced production of ALP, PICP, OC and TGFbeta-1, and reduced IL-6 levels.	calcium phosphate	56-65	interleukin 6	Homo sapiens	130-134
12925613-3	2003	The objective of this study was to create an injectable composite based on calcium phosphate cement embedded with PLGA microparticles for sustained delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2).	calcium phosphate	75-92	bone morphogenetic protein 2	Homo sapiens	178-206
12060866-0	2002	Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.	calcium phosphate	37-54	statherin	Homo sapiens	102-111
12382973-0	2002	Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model.	calcium phosphate	85-102	bone morphogenetic protein 2	Homo sapiens	44-72
14643760-5	2003	We constructed green fluorescent protein-tagged 5-HT(2A) receptors wherein potential sorting motifs were disrupted, and subsequently employed either the Semliki Forest virus or calcium phosphate for the transient expression of recombinant 5-HT(2A) receptors in cultured cortical pyramidal neurons.	calcium phosphate	177-194	5-hydroxytryptamine receptor 2A	Homo sapiens	239-246
12322972-3	2002	Osteoblast cultures (MG 63) demonstrated that PMMA + alpha-TCP significantly and positively affected osteoblast viability, synthetic activity and interleukin-6 level as compared to PMMA.	calcium phosphate	53-62	interleukin-6	Oryctolagus cuniculus	146-159
12369414-4	2002	Dissociation of TGase-treated casein micelles by urea or sodium citrate or removal of colloidal calcium phosphate by acidification and dialysis was reduced, presumably due to the formation of cross-links between the caseins.	calcium phosphate	96-113	transglutaminase 1	Homo sapiens	16-21
12060866-0	2002	Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.	calcium phosphate	37-54	histatin 1	Homo sapiens	117-127
12060866-1	2002	This study quantitatively compares the inhibition of calcium phosphate (CaP) precipitation by the salivary acidic proline-rich proteins (PRPs) statherin and histatin-1.	calcium phosphate	53-70	statherin	Homo sapiens	143-152
12060866-1	2002	This study quantitatively compares the inhibition of calcium phosphate (CaP) precipitation by the salivary acidic proline-rich proteins (PRPs) statherin and histatin-1.	calcium phosphate	53-70	histatin 1	Homo sapiens	157-167
12009006-4	2002	RAW 264.7 cells were induced with RANKL to form multinucleated giant osteoclast-like cells (OCLs) that expressed a number of osteoclast-specific markers and were able to form resorption pits on both calcium phosphate films and bone slices.	calcium phosphate	199-216	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	34-39
12023890-6	2002	Peak levels of mols of P-Ser/mol of BSP coincided with maximum rates of Ca-P deposition in calvarial implants.	calcium phosphate	72-76	integrin binding sialoprotein	Homo sapiens	36-39
12023890-9	2002	Further evaluation of the data provides the first evidence of a direct and linear relationship between the rate of Ca-P deposition and the ratio of P-Ser-BSP/P-Ser-OPN for calvarial implants.	calcium phosphate	115-119	integrin binding sialoprotein	Homo sapiens	154-157
12023890-9	2002	Further evaluation of the data provides the first evidence of a direct and linear relationship between the rate of Ca-P deposition and the ratio of P-Ser-BSP/P-Ser-OPN for calvarial implants.	calcium phosphate	115-119	secreted phosphoprotein 1	Homo sapiens	164-167
11835161-7	2002	Significantly higher OC levels were expressed on smooth titanium, and even higher levels on the crystalline Ca-P coating.	calcium phosphate	108-112	bone gamma-carboxyglutamate protein	Rattus norvegicus	21-23
11794323-1	2002	The osteoconductive properties of calcium phosphate cements (CPCs) may be improved by the addition of growth factors, such as recombinant human transforming growth factor-beta1 (rhTGF-beta1).	calcium phosphate	34-51	transforming growth factor beta 1	Homo sapiens	144-176
11745562-0	2002	Transforming growth factor-beta1 incorporation in a calcium phosphate bone cement: material properties and release characteristics.	calcium phosphate	52-69	transforming growth factor, beta 1	Rattus norvegicus	0-32
11745562-1	2002	The bone regenerative properties of calcium phosphate cements (CPCs) may be improved by the addition of growth factors, such as recombinant human transforming growth factor-beta1 (rhTGF-beta1).	calcium phosphate	36-53	transforming growth factor beta 1	Homo sapiens	146-178
14696253-1	2002	Transformed rat embryo fibroblasts E1A + cHa-ras known to possess high proapoptotic sensitivity and not to be arrested after DNA damage or upon serum starvation, were transfected with bcl-2 gene using calcium-phosphate precipitation method.	calcium phosphate	201-218	BCL2, apoptosis regulator	Rattus norvegicus	184-189
11828383-6	2002	RESULTS: Following transfection of a FasL expression vector by calcium phosphate precipitation, an unexpected increase was observed in apoptotic cell death in previously Fas-resistant Psi-CRIP cells.	calcium phosphate	63-80	Fas ligand (TNF superfamily, member 6)	Mus musculus	37-41
11828383-6	2002	RESULTS: Following transfection of a FasL expression vector by calcium phosphate precipitation, an unexpected increase was observed in apoptotic cell death in previously Fas-resistant Psi-CRIP cells.	calcium phosphate	63-80	cysteine-rich protein 1 (intestinal)	Mus musculus	188-192
11737105-0	2001	Transforming growth factor-beta1 incorporated in calcium phosphate cement stimulates osteotransductivity in rat calvarial bone defects.	calcium phosphate	49-66	transforming growth factor, beta 1	Rattus norvegicus	0-32
11803269-9	2002	In matrices of CaP crystals, the principal proteins were Tamm-Horsfall protein followed by albumin, prothrombin-related proteins and osteopontin.	calcium phosphate	15-18	secreted phosphoprotein 1	Homo sapiens	133-144
11737105-3	2001	We have shown earlier that the intermixing of the recombinant human transforming growth factor-beta1 (rhTGF-beta1) in hardening calcium phosphate cement stimulated osteoblastic differentiation of rat primary bone cells in vitro.	calcium phosphate	128-145	transforming growth factor beta 1	Homo sapiens	68-100
11764390-9	2001	These observations indicated that modifications of ionic exchanges due to a defect in targeting of CFTR AF508 to the apical plasma membrane led to the formation of crystals of calcium phosphate in the cytoplasm of pulmonary cells.	calcium phosphate	176-193	CF transmembrane conductance regulator	Homo sapiens	99-103
11702230-4	2001	with a sense pSVK3-AChErab-cDNA expression vector encoding for the entire rabbit AChE gene by calcium phosphate precipitation.	calcium phosphate	94-111	ACE-1	Oryctolagus cuniculus	19-23
11259591-3	2001	The recent suggestion that Pak3 could stimulate Raf-1 activity by directly phosphorylating S338 through a Ras/phosphatidylinositol 3-kinase (Pl3-K)/-Cdc42-dependent pathway has attracted much attention.	calcium phosphate	91-95	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	48-53
11820459-1	2001	Previously, we demonstrated that amorphous calcium phosphate (ACP), chemical precursor to apatite, strongly interacted with fibrin and facilitated binding of matrix metalloproteinase (MMP)-9, a type IV collagenase.	calcium phosphate	43-60	matrix metallopeptidase 9	Homo sapiens	158-190
11416860-6	2001	The specific alkaline phosphatase (ALP) enzyme activity (ALP/DNA) measured in the supernatants of alpha-TCP-grown cells was nine times higher than the lowest activity, as observed by cells incubated on GB9N.	calcium phosphate	98-107	alkaline phosphatase, placental	Homo sapiens	13-33
11416860-6	2001	The specific alkaline phosphatase (ALP) enzyme activity (ALP/DNA) measured in the supernatants of alpha-TCP-grown cells was nine times higher than the lowest activity, as observed by cells incubated on GB9N.	calcium phosphate	98-107	alkaline phosphatase, placental	Homo sapiens	35-38
11416860-6	2001	The specific alkaline phosphatase (ALP) enzyme activity (ALP/DNA) measured in the supernatants of alpha-TCP-grown cells was nine times higher than the lowest activity, as observed by cells incubated on GB9N.	calcium phosphate	98-107	alkaline phosphatase, placental	Homo sapiens	57-60
11416860-8	2001	Cells grown on bone substitutes and bioglass seem to be less differentiated than alpha-TCP-grown cells, because of noticeably less amounts of osteocalcin and bone sialoprotein.	calcium phosphate	81-90	bone gamma-carboxyglutamate protein	Homo sapiens	142-153
11555022-0	2001	Calcium phosphate crystal-associated proteins: alpha-2-HS-glycoprotein, prothrombin fragment 1 and osteopontin.	calcium phosphate	0-17	secreted phosphoprotein 1	Homo sapiens	99-110
15348248-8	2001	In vitro study revealed that the composites incorporating silanized HAp formed a compact and continuous calcium phosphate layer on their surface after 4 weeks immersion in a simulated body fluid (SBF).	calcium phosphate	104-121	retinoic acid receptor beta	Homo sapiens	68-71
11259591-0	2001	S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.	calcium phosphate	0-4	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	24-29
11259591-2	2001	Ras is required to recruit Raf-1 to the plasma membrane, which is where S338 phosphorylation occurs.	calcium phosphate	72-76	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	27-32
11259591-3	2001	The recent suggestion that Pak3 could stimulate Raf-1 activity by directly phosphorylating S338 through a Ras/phosphatidylinositol 3-kinase (Pl3-K)/-Cdc42-dependent pathway has attracted much attention.	calcium phosphate	91-95	p21 (RAC1) activated kinase 3	Homo sapiens	27-31
15348269-9	2001	The measurements of Ca and P concentrations versus soaking time in SBF2 showed that the carbonated Ca-P layer partially dissolved before the deposition of the OCP coating.	calcium phosphate	99-103	SET binding factor 2	Homo sapiens	67-71
11819786-2	2001	METHODS: Activated H-ras oncogene was transfected into SMMC 7721, a cell line derived from human HCC, by calcium phosphate transfection method.	calcium phosphate	105-122	HRas proto-oncogene, GTPase	Homo sapiens	19-24
11259591-3	2001	The recent suggestion that Pak3 could stimulate Raf-1 activity by directly phosphorylating S338 through a Ras/phosphatidylinositol 3-kinase (Pl3-K)/-Cdc42-dependent pathway has attracted much attention.	calcium phosphate	91-95	cell division cycle 42	Homo sapiens	149-154
11758445-1	2001	ACP is a unique calcium phosphate in that it lacks long-range crystalline order.	calcium phosphate	16-33	CPAT1	Homo sapiens	0-3
11210238-4	2001	Urines with high calcium content (> or = 400 mg L-1) can interfere the method based on the crystallisation of calcium phosphate.	calcium phosphate	113-130	immunoglobulin kappa variable 1-16	Homo sapiens	51-54
11189054-0	2001	45S5 bioactive glass surface charge variations and the formation of a surface calcium phosphate layer in a solution containing fibronectin.	calcium phosphate	78-95	fibronectin 1	Homo sapiens	127-138
11189054-2	2001	We hypothesize that the adsorption of fibronectin on BG changes the surface charge and alters the kinetics of Ca-P layer formation on the glass surface.	calcium phosphate	110-114	fibronectin 1	Homo sapiens	38-49
11189054-6	2001	It was found that the adsorption of fibronectin reduced the initial electronegativity of the BG surface and delayed the formation of both the amorphous and the crystalline Ca-P layers.	calcium phosphate	172-176	fibronectin 1	Homo sapiens	36-47
11189054-9	2001	The addition of a single protein (in this case fibronectin) can significantly alter material surface parameters, such as charge, and subsequently affect the formation of a surface Ca-P layer.	calcium phosphate	180-184	fibronectin 1	Homo sapiens	47-58
11026652-4	2000	Human embryonic kidney (HEK)-293 cells were transfected with plasmids containing VEGF and sFLT-1 (pCMV-VEGF and pCMV-sFLT-1) by the calcium-phosphate co-precipitation method.	calcium phosphate	132-149	vascular endothelial growth factor A	Homo sapiens	81-85
10982813-13	2000	With rAAV-NDI1 as the gene delivery method, we were able to achieve high transduction efficiencies (nearly 100%) even in 143B cells that are difficult to transfect by lipofection or calcium phosphate precipitation methods.	calcium phosphate	182-199	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	10-14
11360693-3	2000	The interferon-gamma (IFN-gamma) transfection was performed with coprecipitation of calcium phosphate and DNA.	calcium phosphate	84-101	interferon gamma	Mus musculus	4-20
10971289-0	2000	Inhibitory effect of calcium phosphate-associated proteins on calcium oxalate crystallization: alpha2-HS-glycoprotein, prothrombin-F1 and osteopontin.	calcium phosphate	21-38	secreted phosphoprotein 1	Homo sapiens	119-149
10971289-8	2000	CONCLUSION: alpha2-HS-glycoprotein, prothrombin fragment 1 and osteopontin selectively bound with calcium phosphate crystals in urine.	calcium phosphate	98-115	secreted phosphoprotein 1	Homo sapiens	63-74
10886734-6	2000	These results suggest that OPN produced and promptly secreted by macrophages and subsequently translocated to psammoma bodies may be causally related with the calcium phosphate deposition in the psammoma bodies of the ovarian serous papillary cystadenocarcinomas.	calcium phosphate	159-176	secreted phosphoprotein 1	Homo sapiens	27-30
11087036-6	2000	RESULTS: Glucose-responsive reporter gene expression was obtained in both calcium phosphate transfected HIT-T15 and betaHC-9 cells, demonstrating regulated luciferase gene expression under control of the insulin gene promoter.	calcium phosphate	74-91	insulin	Mesocricetus auratus	204-211
11360693-3	2000	The interferon-gamma (IFN-gamma) transfection was performed with coprecipitation of calcium phosphate and DNA.	calcium phosphate	84-101	interferon gamma	Mus musculus	22-31
10898885-1	2000	Osteoconductivity of newly developed calcium phosphate cements (CP-1, CP-2) was estimated in mandibular periapical alveolar bone of rats.	calcium phosphate	37-54	cathepsin L	Rattus norvegicus	70-74
10720215-2	2000	We therefore analysed the relationships between indices of calcium-phosphate metabolism in respect to VDR genotype in 180 hemodialysed patients.	calcium phosphate	59-76	vitamin D receptor	Homo sapiens	102-105
10644965-0	2000	Transforming growth factor-beta1 incorporated during setting in calcium phosphate cement stimulates bone cell differentiation in vitro.	calcium phosphate	64-81	transforming growth factor beta 1	Homo sapiens	0-32
10644965-4	2000	In this study we hypothesise that the addition of recombinant human TGF-beta1 (rhTGF-beta1) to calcium phosphate cement (CPC) affects the differentiation of bone cells growing on the cement layer.	calcium phosphate	95-112	transforming growth factor beta 1	Homo sapiens	68-77
10602067-0	2000	Calcium phosphate deposition on titanium surfaces in the presence of fibronectin.	calcium phosphate	0-17	fibronectin 1	Homo sapiens	69-80
10602067-5	2000	The concentration of fibronectin in the HBSS solution was an important parameter in the process of calcium phosphate deposition.	calcium phosphate	99-116	fibronectin 1	Homo sapiens	21-32
10992156-5	2000	Two indirect methods showed that calcium-phosphate precipitation was inhibited by VN.	calcium phosphate	33-50	vitronectin	Homo sapiens	82-84
12548859-3	1999	CD80 expression cells were selected by G418 from pLXSN-CD80 transfected PA317 and CHO cells by calcium phosphate.	calcium phosphate	95-112	CD80 antigen	Mus musculus	0-4
11156706-0	2000	Calcium phosphate crystal-associated proteins: alpha2-HS-glycoprotein, prothrombin F1, and osteopontin.	calcium phosphate	0-17	alpha 2-HS glycoprotein	Homo sapiens	47-69
11156706-2	2000	MATERIALS AND METHODS: We analyzed specific binding proteins of calcium phosphate (CaP) crystals generated in human urine and found that the separated proteins were alpha2-HS-glycoprotein, prothrombin fragment 1 (PTF1), and osteopontin (OPN).	calcium phosphate	64-81	alpha 2-HS glycoprotein	Homo sapiens	165-187
11156706-2	2000	MATERIALS AND METHODS: We analyzed specific binding proteins of calcium phosphate (CaP) crystals generated in human urine and found that the separated proteins were alpha2-HS-glycoprotein, prothrombin fragment 1 (PTF1), and osteopontin (OPN).	calcium phosphate	83-86	alpha 2-HS glycoprotein	Homo sapiens	165-187
10331242-3	1999	In this context, the mineralization potential of fibronectin was tested in an agarose gel precipitation system and a metastable calcium phosphate solution.	calcium phosphate	128-145	fibronectin 1	Homo sapiens	49-60
10541277-3	1999	Calcium oxalate monohydrate and hydroxyapatite (calcium phosphate) crystals rapidly adhere to anionic sites on the surface of cultured renal epithelial cells, but this process is inhibited by specific urinary anions such as citrate, glycosaminoglycans, uropontin, or nephrocalcin, each of which can coat the crystals.	calcium phosphate	48-65	secreted phosphoprotein 1	Homo sapiens	253-262
10553245-8	1999	For instance, when comparing proteins that inhibit calcium phosphate precipitation, statherin and acidic proline-rich proteins are most potent, whereas histatins, cystatins, and mucins appear to play lesser roles.	calcium phosphate	51-68	statherin	Homo sapiens	84-93
10443797-0	1999	Amorphous calcium phosphate-mediated binding of matrix metalloproteinase-9 to fibrin is inhibited by pyrophosphate and bisphosphonate.	calcium phosphate	10-27	matrix metallopeptidase 9	Homo sapiens	48-74
10443797-4	1999	Fibrin binding of MMP-9 is mediated by amorphous calcium phosphate (ACP), and proceeds in a step-wise fashion with formation of ACP as the first and rate-limiting step.	calcium phosphate	49-66	matrix metallopeptidase 9	Homo sapiens	18-23
10449634-8	1999	In in vitro experiments using a solution of human FN incubated in the presence of calcium phosphate crystals, we obtained apatite crystal precipitation.	calcium phosphate	82-99	fibronectin 1	Homo sapiens	50-52
10380003-0	1999	Incorporation of bovine serum albumin in calcium phosphate coating on titanium.	calcium phosphate	41-58	albumin	Homo sapiens	24-37
10479896-1	1999	BACKGROUND: After treatment of anterior chamber fibrinous reactions by tissue plasminogen activator (TPA), irreversible corneal opacifications (calcium phosphate) have been observed.	calcium phosphate	144-161	plasminogen activator, tissue type	Homo sapiens	101-104
10376721-11	1999	Results of the study strongly suggest that adsorption of serum fibronectin to the surface of modified porous bioactive glass coated with calcium phosphate may be responsible for enhanced osteoblast adhesion.	calcium phosphate	137-154	fibronectin 1	Homo sapiens	63-74
15348155-0	1999	Production and characterization of new calcium phosphate bone cements in the CaHPO4-alpha-Ca3(PO4)2 system: pH, workability and setting times.	calcium phosphate	39-56	ERC2 intronic transcript 1	Homo sapiens	94-99
11819409-1	1999	AIM:To study the inducible expression of hepatitis C virus ns3 gene (HCV ns3) in eukaryotic cells.METHODS: The ns3 gene was obtained from plasmid pBns3 by polymerase chain reaction and inserted into the cloning vector pGEM-T. Then, the ns3 was subcloned into the vector pMSG to generate dexamethasone (DM)-inducible expression plasmid pMSG-ns3.CHO cells were transfected by pMSG-ns3 using calcium phosphate precip-itation method and cultivated for 12h-24h.	calcium phosphate	389-406	KRAS proto-oncogene, GTPase	Homo sapiens	59-62
11819409-1	1999	AIM:To study the inducible expression of hepatitis C virus ns3 gene (HCV ns3) in eukaryotic cells.METHODS: The ns3 gene was obtained from plasmid pBns3 by polymerase chain reaction and inserted into the cloning vector pGEM-T. Then, the ns3 was subcloned into the vector pMSG to generate dexamethasone (DM)-inducible expression plasmid pMSG-ns3.CHO cells were transfected by pMSG-ns3 using calcium phosphate precip-itation method and cultivated for 12h-24h.	calcium phosphate	389-406	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
11819409-1	1999	AIM:To study the inducible expression of hepatitis C virus ns3 gene (HCV ns3) in eukaryotic cells.METHODS: The ns3 gene was obtained from plasmid pBns3 by polymerase chain reaction and inserted into the cloning vector pGEM-T. Then, the ns3 was subcloned into the vector pMSG to generate dexamethasone (DM)-inducible expression plasmid pMSG-ns3.CHO cells were transfected by pMSG-ns3 using calcium phosphate precip-itation method and cultivated for 12h-24h.	calcium phosphate	389-406	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
11819409-1	1999	AIM:To study the inducible expression of hepatitis C virus ns3 gene (HCV ns3) in eukaryotic cells.METHODS: The ns3 gene was obtained from plasmid pBns3 by polymerase chain reaction and inserted into the cloning vector pGEM-T. Then, the ns3 was subcloned into the vector pMSG to generate dexamethasone (DM)-inducible expression plasmid pMSG-ns3.CHO cells were transfected by pMSG-ns3 using calcium phosphate precip-itation method and cultivated for 12h-24h.	calcium phosphate	389-406	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
11819409-1	1999	AIM:To study the inducible expression of hepatitis C virus ns3 gene (HCV ns3) in eukaryotic cells.METHODS: The ns3 gene was obtained from plasmid pBns3 by polymerase chain reaction and inserted into the cloning vector pGEM-T. Then, the ns3 was subcloned into the vector pMSG to generate dexamethasone (DM)-inducible expression plasmid pMSG-ns3.CHO cells were transfected by pMSG-ns3 using calcium phosphate precip-itation method and cultivated for 12h-24h.	calcium phosphate	389-406	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
11819409-1	1999	AIM:To study the inducible expression of hepatitis C virus ns3 gene (HCV ns3) in eukaryotic cells.METHODS: The ns3 gene was obtained from plasmid pBns3 by polymerase chain reaction and inserted into the cloning vector pGEM-T. Then, the ns3 was subcloned into the vector pMSG to generate dexamethasone (DM)-inducible expression plasmid pMSG-ns3.CHO cells were transfected by pMSG-ns3 using calcium phosphate precip-itation method and cultivated for 12h-24h.	calcium phosphate	389-406	KRAS proto-oncogene, GTPase	Homo sapiens	73-76
9659610-0	1998	Basic fibroblast growth factor adsorption and release properties of calcium phosphate.	calcium phosphate	68-85	fibroblast growth factor 2	Homo sapiens	0-30
16232475-1	1999	Calcium phosphate ceramics constructed from beta-tricalcium phosphate (TCP) and hydroxyapatite (HAP) have been successfully used as implant materials.	calcium phosphate	0-17	retinoic acid receptor, beta	Mus musculus	44-100
9918811-0	1998	Inducibility of BDNF gene promoter I detected by calcium-phosphate-mediated DNA transfection is confined to neuronal but not to glial cells.	calcium phosphate	49-66	brain-derived neurotrophic factor	Rattus norvegicus	16-20
9788502-1	1998	The setting reactions of calcium phosphate cements in the CaHPO4-alpha-Ca3(PO4)2 (DCP-alpha-TCP) system have been investigated.	calcium phosphate	25-42	ERC2 intronic transcript 1	Homo sapiens	75-80
9824774-0	1998	Binding of matrix metalloproteinase 9 to fibrin is mediated by amorphous calcium-phosphate.	calcium phosphate	73-90	matrix metallopeptidase 9	Homo sapiens	11-37
9824774-3	1998	We found that MMP-9 to fibrin was dependent on formation of a calcium-phosphate intermediate.	calcium phosphate	62-79	matrix metallopeptidase 9	Homo sapiens	14-19
9880100-6	1998	The feline TPO cDNA fragment encoding the whole amino acid coding region was recloned into an expression vector, and the resulting vector was transfected into 293T cells using the calcium phosphate method.	calcium phosphate	180-197	thrombopoietin	Homo sapiens	11-14
11263374-2	1998	METHODS: A recombinant retroviral vector expressing wild-type p53 was constructed and packaged by packaging cell line PA317 cells using calcium phosphate coprecipitation method.	calcium phosphate	136-153	transformation related protein 53, pseudogene	Mus musculus	62-65
11717930-2	1998	METHODS: A recombinant retroviral vector expressing wild-type p53 was constructed and packaged by packaging cell line PA317 cells using calcium phosphate coprecipitation method.	calcium phosphate	136-153	transformation related protein 53, pseudogene	Mus musculus	62-65
9786634-7	1998	Furthermore, TGF-beta1 down-regulated the osteoblast-like phenotype of PDL cells, i.e., alkaline phosphatase activity, calcium phosphate nodule formation, expression of osteocalcin, and TGF-beta1, in a dose-dependent manner.	calcium phosphate	119-136	transforming growth factor beta 1	Homo sapiens	13-22
9599032-0	1998	Growth hormone-loaded macroporous calcium phosphate ceramic: in vitro biopharmaceutical characterization and preliminary in vivo study.	calcium phosphate	34-51	somatotropin	Oryctolagus cuniculus	0-14
9741686-6	1998	In the absence of mucin, only human serum albumin plus CBP, not these proteins individually, decreased the stimulating effect of calcium phosphate precipitates but not of soluble calcium.	calcium phosphate	129-146	albumin	Homo sapiens	36-49
9741686-6	1998	In the absence of mucin, only human serum albumin plus CBP, not these proteins individually, decreased the stimulating effect of calcium phosphate precipitates but not of soluble calcium.	calcium phosphate	129-146	centrin 1	Homo sapiens	55-58
9741686-7	1998	However, seeding of calcium phosphate precipitates in biles with mucins resulted in near complete cholesterol crystallization within one day whether CBP and HSA were or were not also present.	calcium phosphate	20-37	centrin 1	Homo sapiens	149-152
9599032-2	1998	The present work investigated the efficacy of macroporous biphasic calcium phosphate (MBCP) implants as a matrix for local delivery of human growth hormone (hGH).	calcium phosphate	67-84	growth hormone 1	Homo sapiens	141-155
9523714-0	1998	A core-shell model of calcium phosphate nanoclusters stabilized by beta-casein phosphopeptides, derived from sedimentation equilibrium and small-angle X-ray and neutron-scattering measurements.	calcium phosphate	22-39	casein beta	Bos taurus	67-78
12014144-1	1998	We have constructed pSG5-RAR gamma-neo plasmid containing mouse retinoic acid receptor gamma (RAR gamma) gene and neo gene, and introduced it into embryonic stem ES-5 cells, by calcium phosphate mediated transfection.	calcium phosphate	177-194	retinoic acid receptor, gamma	Mus musculus	25-34
9692865-1	1998	Mouse polymeric immunoglobulin receptor (pIgR) cDNA was stably introduced into a hamster-derived fibroblastic cell line, Chinese hamster ovary (CHO) cell, by the calcium phosphate method.	calcium phosphate	162-179	polymeric immunoglobulin receptor	Mus musculus	6-39
9692865-1	1998	Mouse polymeric immunoglobulin receptor (pIgR) cDNA was stably introduced into a hamster-derived fibroblastic cell line, Chinese hamster ovary (CHO) cell, by the calcium phosphate method.	calcium phosphate	162-179	polymeric immunoglobulin receptor	Mus musculus	41-45
9511101-0	1998	Growth hormone stimulates the degradation of calcium phosphate biomaterial by human monocytes macrophages in vitro.	calcium phosphate	45-62	growth hormone 1	Homo sapiens	0-14
9556073-0	1998	Human growth hormone locally released in bone sites by calcium-phosphate biomaterial stimulates ceramic bone substitution without systemic effects: a rabbit study.	calcium phosphate	55-72	somatotropin	Oryctolagus cuniculus	6-20
9556073-2	1998	This study investigated the efficacy of local administration of human growth hormone (hGH) by macroporous biphasic calcium phosphate (MBCP) implants in improving the bone substitution qualities of ceramics.	calcium phosphate	115-132	growth hormone 1	Homo sapiens	70-84
9548788-1	1998	Zeolite A and calcium phosphate modified Zeolite A have been shown to be a new effective packing material in ion exchange chromatography for the purification of immunoglobulin G (IgG) from binary mixtures and mouse ascites fluid.	calcium phosphate	14-31	immunoglobulin heavy variable V1-62	Mus musculus	161-177
9548788-1	1998	Zeolite A and calcium phosphate modified Zeolite A have been shown to be a new effective packing material in ion exchange chromatography for the purification of immunoglobulin G (IgG) from binary mixtures and mouse ascites fluid.	calcium phosphate	14-31	immunoglobulin heavy variable V1-62	Mus musculus	179-182
9579549-5	1998	Different types of cells were transfected with the pG3Z:K14-TGF-beta1 construct using the calcium phosphate method.	calcium phosphate	90-107	transforming growth factor beta 1	Felis catus	60-69
9523714-1	1998	Calcium phosphate nanoclusters were prepared under standardised conditions using 10 mg ml(-1) of the 25-amino-acid N-terminal tryptic phosphopeptide of bovine beta-casein as a stabilising agent.	calcium phosphate	0-17	casein beta	Bos taurus	159-170
9389489-10	1997	Although IGFBP-5, when bound to extracellular matrix, augments the action of IGF, we believe that in the involuting mammary gland IGFBP-5 inhibits IGF action by interacting with casein micelles, which contain calcium phosphate nanoclusters, thereby preventing IGF interaction with IGF receptors.	calcium phosphate	209-226	insulin-like growth factor binding protein 5	Rattus norvegicus	130-137
9678875-0	1998	Cortical bone ingrowth in growth hormone-loaded grooved implants with calcium phosphate coatings in goat femurs.	calcium phosphate	70-87	growth hormone	Capra hircus	26-40
9678875-17	1998	We conclude that recombinant human growth hormone inhibits bone formation in the grooves coated with calcium phosphate.	calcium phosphate	101-118	growth hormone 1	Homo sapiens	35-49
8978656-10	1997	The transition of solid Polyactive into a Polyactive hydrogel in calcium phosphate solution permitted HCAp formation within the polymer.	calcium phosphate	65-82	HCA1	Homo sapiens	102-106
9365840-6	1997	OPN was identified in calcium oxalate dihydrate and calcium phosphate stones, but was absent in magnesium ammonium phosphate and uric acid stones.	calcium phosphate	52-69	secreted phosphoprotein 1	Homo sapiens	0-3
9025902-4	1997	beta-Galactosidase protein is readily internalized by adherent cell lines when incorporated into a calcium phosphate precipitate; significant enzyme activity can be recovered up to 72 h after transfection.	calcium phosphate	99-116	galactosidase beta 1	Homo sapiens	0-18
9333121-9	1997	Consistent with these results, porous calcium phosphate ceramic cubes implanted in vivo, which were loaded with MSCs pre-exposed to both bFGF and BMP-2, showed higher histologic score for bone formation than those with MSCs pre-exposed to either bFGF or BMP-2 alone.	calcium phosphate	38-55	fibroblast growth factor 2	Rattus norvegicus	137-141
9333121-9	1997	Consistent with these results, porous calcium phosphate ceramic cubes implanted in vivo, which were loaded with MSCs pre-exposed to both bFGF and BMP-2, showed higher histologic score for bone formation than those with MSCs pre-exposed to either bFGF or BMP-2 alone.	calcium phosphate	38-55	bone morphogenetic protein 2	Rattus norvegicus	146-151
9333121-9	1997	Consistent with these results, porous calcium phosphate ceramic cubes implanted in vivo, which were loaded with MSCs pre-exposed to both bFGF and BMP-2, showed higher histologic score for bone formation than those with MSCs pre-exposed to either bFGF or BMP-2 alone.	calcium phosphate	38-55	fibroblast growth factor 2	Rattus norvegicus	246-250
9333121-9	1997	Consistent with these results, porous calcium phosphate ceramic cubes implanted in vivo, which were loaded with MSCs pre-exposed to both bFGF and BMP-2, showed higher histologic score for bone formation than those with MSCs pre-exposed to either bFGF or BMP-2 alone.	calcium phosphate	38-55	bone morphogenetic protein 2	Rattus norvegicus	254-259
9261688-3	1997	In the present work, human recombinant growth hormone was loaded on biphasic calcium phosphate powder and consolidated by a specific process of cold sintering (dynamic compaction).	calcium phosphate	77-94	growth hormone 1	Homo sapiens	39-53
10920888-2	1997	METHODS: Activated H-ras oncogenes were transfected into SMMC7721, a cell line derived from human hepatocellular carcinoma (HCC), by calcium phosphate transfection method.	calcium phosphate	133-150	HRas proto-oncogene, GTPase	Homo sapiens	19-24
8978656-3	1997	Our results show that Polyactive is capable of inducing hydroxycarbonate apatite (HCAp) formation from a metastable calcium phosphate solution analogous to a physiological solution.	calcium phosphate	116-133	HCA1	Homo sapiens	82-86
8655630-5	1996	We also document the production of stable MRP/PLF mRNA generated by transcription of various plasmid constructs containing different portions of the MRP/PLF3 gene after calcium phosphate-mediated transfection into the MEFs.	calcium phosphate	169-186	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	42-45
9048421-0	1996	Solid-phase synthesis and characterization of human salivary statherin: a tyrosine-rich phosphoprotein inhibitor of calcium phosphate precipitation.	calcium phosphate	116-133	statherin	Homo sapiens	61-70
8813078-0	1996	Ultrastructural study of degradation of calcium phosphate ceramic by human monocytes and modulation of this activity by HILDA/LIF cytokine.	calcium phosphate	40-57	LIF interleukin 6 family cytokine	Homo sapiens	126-129
8673728-5	1996	Results showed that calcium phosphate transfection was optimal for fetal hepatocytes with respect to beta-galactosidase activity and cell survival.	calcium phosphate	20-37	galactosidase beta 1	Homo sapiens	101-119
8661513-8	1996	The mutant cells were transiently transfected with a pCMV/NHE-2 expression vector using calcium phosphate precipitation method.	calcium phosphate	88-105	solute carrier family 9 member A2	Sus scrofa	58-63
8661960-10	1996	A sequence is proposed of successive steps of LaP nucleation within the focal filament aggregates, which possibly mimics calcium phosphate deposition.	calcium phosphate	121-138	acid phosphatase 2, lysosomal	Rattus norvegicus	46-49
8830055-4	1996	Very-long-chain acyl-CoA synthetase has been extracted from the washed membrane fraction of frozen rat liver peroxisomes with a buffer containing a detergent, and has been purified by chromatography on Ultrogel AcA 34, calcium phosphate gel/cellulose, blue dextran-Sepharose 4B and DEAE-Toyopearl.	calcium phosphate	219-236	solute carrier family 27 member 2	Rattus norvegicus	0-35
9004453-3	1996	A retroviral vector construct, containing a human CYP2C10 cDNA, was transfected in V79-NH Chinese hamster lung cells by calcium phosphate co-precipitation.	calcium phosphate	120-137	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	50-57
8897141-7	1996	The results showed that: 1) alpha-TCP reacted to a calcium-deficient hydroxyapatite (CDHA), Ca9(HPO4)(PO4)5O H, whereas DCP did not react significantly; 2) the reaction was nearly finished within 32 h, during which both the reaction percentage and the compressive strength increased versus time, with a strong correlation between them; and 3) the calcium phosphate bone cement showed in general a structure of groups of interconnected large plates distributed among agglomerations of small crystal plates arranged in very dense packings.	calcium phosphate	28-37	carbonic anhydrase 9	Homo sapiens	92-95
8889837-0	1996	PTH-related protein is released into the mother"s bloodstream during lactation: evidence for beneficial effects on maternal calcium-phosphate metabolism.	calcium phosphate	124-141	parathyroid hormone like hormone	Homo sapiens	0-19
8858933-1	1996	The rat N-methyl-D-aspartate (NMDA) glutamate receptor subunit NR1-1a was transiently expressed in COS cells using the technique of electroporation, which was fivefold more efficient than the calcium phosphate precipitation method of transfection.	calcium phosphate	192-209	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	8-54
8655630-5	1996	We also document the production of stable MRP/PLF mRNA generated by transcription of various plasmid constructs containing different portions of the MRP/PLF3 gene after calcium phosphate-mediated transfection into the MEFs.	calcium phosphate	169-186	prolactin family 2, subfamily c, member 2	Mus musculus	46-49
10479440-0	1996	The Dual Role of Fibrinogen as Inhibitor and Nucleator of Calcium Phosphate Phases: The Importance of Structure.	calcium phosphate	58-75	fibrinogen beta chain	Homo sapiens	17-27
8683457-11	1996	However, when the flow was stopped in the presence of 60 mM Pi and 10 mM CP, a prolonged decrease in [Ca2+] occurred, consistent with precipitation of calcium phosphate within the SR. A similar decrease in [Ca2+] was observed when perfusion was stopped in the presence of 2 or 20 mM oxalate, in the absence or presence of CP.	calcium phosphate	151-168	carbonic anhydrase 2	Rattus norvegicus	102-105
10479440-1	1996	Constant composition and free drift methods have been used to investigate the abilities of human serum albumin (HSA) and fibrinogen to influence calcium phosphate precipitation.	calcium phosphate	145-162	fibrinogen beta chain	Homo sapiens	97-131
10479440-3	1996	Fibrinogen, when immobilized at hydrophobicized germanium or silica surfaces, is able to nucleate calcium phosphate phases; at clean germanium or silica surfaces, it appears to be inactive.	calcium phosphate	98-115	fibrinogen beta chain	Homo sapiens	0-10
8761340-6	1996	Also, ET-1 in a concentration-dependent manner (0.1 nM-0.1 microM) induced expression of the chloramphenicol acetyl transferase gene driven by 896 bp of the human SM alpha-actin promoter when transiently transfected into rat aortic VSMCs by the calcium phosphate method (141.2 +/- 9.8%, mean +/- SEM, n = 10).	calcium phosphate	245-262	endothelin 1	Homo sapiens	6-10
8788601-2	1996	Using the calcium-phosphate co-precipitation method, a reporter gene which encodes bacterial beta-galactosidase was introduced into cultured mesangial cells derived from renal biopsy tissue of rats.	calcium phosphate	10-27	galactosidase, beta 1	Rattus norvegicus	93-111
8761340-6	1996	Also, ET-1 in a concentration-dependent manner (0.1 nM-0.1 microM) induced expression of the chloramphenicol acetyl transferase gene driven by 896 bp of the human SM alpha-actin promoter when transiently transfected into rat aortic VSMCs by the calcium phosphate method (141.2 +/- 9.8%, mean +/- SEM, n = 10).	calcium phosphate	245-262	survival of motor neuron 1, telomeric	Homo sapiens	163-171
7753562-0	1995	p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts.	calcium phosphate	38-55	transformation related protein 53, pseudogene	Mus musculus	0-3
9813627-2	1996	Fibrinogen and collagen molecules adsorbed at hydrophobic surfaces as well as uncross-linked collagen fibrils induce ion binding and subsequent nucleation of calcium phosphate.	calcium phosphate	158-175	fibrinogen beta chain	Homo sapiens	0-10
7557151-0	1995	Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation.	calcium phosphate	80-97	mucin 1, cell surface associated	Bos taurus	34-39
7666059-6	1995	Immunohistochemistry with anti-OPN antibody and von Kossa staining on the adjacent section showed that the deposition site of OPN protein was consistent with that of calcium phosphate.	calcium phosphate	166-183	secreted phosphoprotein 1	Homo sapiens	126-129
7615968-0	1995	Possible role of osteopontin in deposition of calcium phosphate in human pilomatricomas.	calcium phosphate	46-63	secreted phosphoprotein 1	Homo sapiens	17-28
7615968-3	1995	Because osteopontin is believed to be involved in the deposition of calcium phosphate in bones, we asked whether osteopontin messenger RNA also is expressed in pilomatricomas.	calcium phosphate	68-85	secreted phosphoprotein 1	Canis lupus familiaris	8-19
7615968-6	1995	Immunohistochemistry of anti-human osteopontin antibodies revealed that the localization of osteopontin protein was consistent with that of calcium phosphate.	calcium phosphate	140-157	secreted phosphoprotein 1	Canis lupus familiaris	35-46
7615968-7	1995	The present results suggest that osteopontin produced by macrophages may play a significant role in the deposition of calcium phosphate in the shadow cell nests of pilomatricomas.	calcium phosphate	118-135	secreted phosphoprotein 1	Canis lupus familiaris	33-44
7753562-3	1995	Here we report the effect of calcium phosphate-mediated transfection, a technique commonly used in studies of transient gene expression in mammalian cells, on fibroblasts containing wild-type p53.	calcium phosphate	29-46	tumor protein p53	Homo sapiens	192-195
7773437-3	1995	We report the first use of the calcium phosphate procedure to successfully transfect adult rat dorsal root ganglion neurons, which naturally express the calcitonin/calcitonin gene-related peptide (CGRP) in an NGF-inducible manner.	calcium phosphate	31-48	calcitonin-related polypeptide alpha	Rattus norvegicus	153-195
7656817-1	1995	An eukaryotic expression vector containing tumor necrosis factor alpha (TNF alpha) gene (psVK3-tnf) was transduced into hepatocellular carcinoma (HCC) cell line, SMMC7721, by calcium phosphate coprecipation method.	calcium phosphate	175-192	tumor necrosis factor	Mus musculus	43-70
7656817-1	1995	An eukaryotic expression vector containing tumor necrosis factor alpha (TNF alpha) gene (psVK3-tnf) was transduced into hepatocellular carcinoma (HCC) cell line, SMMC7721, by calcium phosphate coprecipation method.	calcium phosphate	175-192	tumor necrosis factor	Mus musculus	72-81
7656817-1	1995	An eukaryotic expression vector containing tumor necrosis factor alpha (TNF alpha) gene (psVK3-tnf) was transduced into hepatocellular carcinoma (HCC) cell line, SMMC7721, by calcium phosphate coprecipation method.	calcium phosphate	175-192	tumor necrosis factor	Homo sapiens	95-98
7656817-3	1995	Three weeks after the pSVK3-tnf DNA entrapped with calcium phosphate was introduced directly into subcutaneous nodules of human HCC in nude mice (treated mice), the growth of HCC was significantly delayed as compared to the pSVK3 group (control mice) (2.5 +/- 1.6 cm vs. 3.2 +/- 1.8 cm, n = 6, P < 0.05).	calcium phosphate	51-68	tumor necrosis factor	Homo sapiens	28-31
7785899-2	1995	Solution studies from a variety of laboratories have shown that while some of these proteins (e.g., osteopontin, dentin sialoprotein) inhibit calcium phosphate production, others, such as bone sialoprotein, can act as a nucleator of calcium phosphate formation.	calcium phosphate	142-159	secreted phosphoprotein 1	Homo sapiens	100-111
7785899-2	1995	Solution studies from a variety of laboratories have shown that while some of these proteins (e.g., osteopontin, dentin sialoprotein) inhibit calcium phosphate production, others, such as bone sialoprotein, can act as a nucleator of calcium phosphate formation.	calcium phosphate	142-159	dentin sialophosphoprotein	Homo sapiens	113-132
7785899-2	1995	Solution studies from a variety of laboratories have shown that while some of these proteins (e.g., osteopontin, dentin sialoprotein) inhibit calcium phosphate production, others, such as bone sialoprotein, can act as a nucleator of calcium phosphate formation.	calcium phosphate	233-250	secreted phosphoprotein 1	Homo sapiens	100-111
7785899-2	1995	Solution studies from a variety of laboratories have shown that while some of these proteins (e.g., osteopontin, dentin sialoprotein) inhibit calcium phosphate production, others, such as bone sialoprotein, can act as a nucleator of calcium phosphate formation.	calcium phosphate	233-250	dentin sialophosphoprotein	Homo sapiens	113-132
7580832-2	1995	Immunization with gp160 in saline induced the formation of antibodies directed to the p18 protein, whereas the gp160 adsorbed onto calcium phosphate elicited antibodies recognizing the gp160, p55, p25 and p18 proteins.	calcium phosphate	131-148	protein disulfide-isomerase	Oryctolagus cuniculus	192-195
7749159-2	1995	Using a modified calcium phosphate method and an ODC cDNA coding for a truncated and more stable enzyme, we were able to achieve a moderate to marked degree of ODC overexpression (up to 150-fold) in a transient transfection system.	calcium phosphate	17-34	ornithine decarboxylase 1	Homo sapiens	160-163
7773437-3	1995	We report the first use of the calcium phosphate procedure to successfully transfect adult rat dorsal root ganglion neurons, which naturally express the calcitonin/calcitonin gene-related peptide (CGRP) in an NGF-inducible manner.	calcium phosphate	31-48	calcitonin-related polypeptide alpha	Rattus norvegicus	197-201
7773437-3	1995	We report the first use of the calcium phosphate procedure to successfully transfect adult rat dorsal root ganglion neurons, which naturally express the calcitonin/calcitonin gene-related peptide (CGRP) in an NGF-inducible manner.	calcium phosphate	31-48	nerve growth factor	Rattus norvegicus	209-212
7812936-1	1994	To test the hypothesis that elevated expression of the glutathione (GSH) salvage enzyme, gamma-glutamyl transpeptidase (gamma-GT) can confer resistance to chemotherapeutic agents, the cDNA for human gamma-GT was introduced into human prostate carcinoma cells by calcium phosphate precipitation.	calcium phosphate	262-279	inactive glutathione hydrolase 2	Homo sapiens	89-118
7766312-7	1995	By using the calcium phosphate precipitate transfection technique, a full-length cDNA-encoding Cx43 and a pSV2neo have been introduced into the RDL6 cells.	calcium phosphate	13-30	gap junction protein alpha 1	Homo sapiens	95-99
7812936-1	1994	To test the hypothesis that elevated expression of the glutathione (GSH) salvage enzyme, gamma-glutamyl transpeptidase (gamma-GT) can confer resistance to chemotherapeutic agents, the cDNA for human gamma-GT was introduced into human prostate carcinoma cells by calcium phosphate precipitation.	calcium phosphate	262-279	inactive glutathione hydrolase 2	Homo sapiens	120-128
8192535-0	1994	Influence of long-term erythropoietin treatment on plasma levels of calcium-phosphate related hormones in haemodialyzed uraemic patients.	calcium phosphate	68-85	erythropoietin	Homo sapiens	23-37
7993580-4	1994	IL-6 together with wtAcMNPV DNAs were transferred into cultured lepidopteran insect cells (Sf9) by calcium phosphate coprecipitation procedure.	calcium phosphate	99-116	interleukin 6	Homo sapiens	0-4
8010953-4	1994	Using metastable calcium phosphate solutions buffered by autotitration, osteopontin caused half-maximal inhibition of HA formation at a concentration (IC50) of 0.06 microgram/ml.	calcium phosphate	17-34	secreted phosphoprotein 1	Homo sapiens	72-83
8137552-2	1994	Human c-fos cDNA was integrated in the expression vector pH8, and the cells were transfected using the calcium phosphate precipitation technique.	calcium phosphate	103-120	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	6-11
7919109-0	1994	Humoral response in rabbits immunized with calcium phosphate adjuvanted HIV-1 gp160 antigen.	calcium phosphate	43-60	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	78-83
8161653-0	1994	Monocyte activity in the presence of calcium phosphate activated by 1,25 (OH)2 VD3 and interferon-gamma.	calcium phosphate	37-54	interferon gamma	Homo sapiens	87-103
8161653-3	1994	A model study of the degradation of bioactive ceramics (calcium phosphate) using human peripheral blood monocytes activated by 1,25 (OH)2 VD3 and interferon (IFN)-gamma was implemented.	calcium phosphate	56-73	interferon gamma	Homo sapiens	146-168
8294488-2	1994	The [3H]azido-Q-labeled cytochrome b protein was purified to homogeneity from the azido-Q-labeled ubiquinol-cytochrome c reductase by a procedure involving Triton X-100 and urea treatment, calcium phosphate column chromatography, acetone precipitation, decanoyl-N-methylglucamide-cholate extraction, and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	calcium phosphate	189-206	cytochrome b	Bos taurus	24-36
7919109-1	1994	Rabbits were immunized with either calcium phosphate adjuvanted purified HIV-1 gp160 or a fluid preparation.	calcium phosphate	35-52	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	79-84
8423625-3	1993	METHODS: Plasmid vectors were used to transfect the R11 RCC line with the genes for human IL-2 and/or IFN-alpha by the calcium phosphate precipitation method.	calcium phosphate	119-136	interleukin 2	Homo sapiens	90-94
8243639-3	1993	Here we show that calcium phosphate-mediated transfection of dorsal root ganglia with an EF-1 alpha promoter-hsp70i expression vector significantly increased the survival of neurones and glia exposed to a severe heat stress.	calcium phosphate	18-35	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	89-99
8243639-3	1993	Here we show that calcium phosphate-mediated transfection of dorsal root ganglia with an EF-1 alpha promoter-hsp70i expression vector significantly increased the survival of neurones and glia exposed to a severe heat stress.	calcium phosphate	18-35	heat shock protein family A (Hsp70) member 1A	Homo sapiens	109-115
7912874-1	1993	Human multidrug resistance gene (mdr1) was introduced into mouse embryonic stem cells (ES-5 line) by calcium phosphate mediated transfection, and transfected ES-5 cells were then selected by stepwise increase in colchicine concentration (30, 50, 100, and 200 ng/ml respectively).	calcium phosphate	101-118	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	33-37
8423625-3	1993	METHODS: Plasmid vectors were used to transfect the R11 RCC line with the genes for human IL-2 and/or IFN-alpha by the calcium phosphate precipitation method.	calcium phosphate	119-136	interferon alpha 1	Homo sapiens	102-111
1516143-1	1992	Transfection of the beta-galactosidase gene in quiescent cultures of adult rat hepatocytes with the calcium phosphate precipitate or the lipofection methods gave a higher level of beta-galactosidase gene expression with the lipofection than with the calcium phosphate precipitate method, but the transfection efficiency was weak in both cases.	calcium phosphate	100-117	galactosidase, beta 1	Rattus norvegicus	20-38
1516143-1	1992	Transfection of the beta-galactosidase gene in quiescent cultures of adult rat hepatocytes with the calcium phosphate precipitate or the lipofection methods gave a higher level of beta-galactosidase gene expression with the lipofection than with the calcium phosphate precipitate method, but the transfection efficiency was weak in both cases.	calcium phosphate	100-117	galactosidase, beta 1	Rattus norvegicus	180-198
1516143-1	1992	Transfection of the beta-galactosidase gene in quiescent cultures of adult rat hepatocytes with the calcium phosphate precipitate or the lipofection methods gave a higher level of beta-galactosidase gene expression with the lipofection than with the calcium phosphate precipitate method, but the transfection efficiency was weak in both cases.	calcium phosphate	250-267	galactosidase, beta 1	Rattus norvegicus	20-38
1516143-1	1992	Transfection of the beta-galactosidase gene in quiescent cultures of adult rat hepatocytes with the calcium phosphate precipitate or the lipofection methods gave a higher level of beta-galactosidase gene expression with the lipofection than with the calcium phosphate precipitate method, but the transfection efficiency was weak in both cases.	calcium phosphate	250-267	galactosidase, beta 1	Rattus norvegicus	180-198
1544408-1	1992	Human kidney 293 TSA cells were transfected by a calcium phosphate method with human formylpeptide and C5a receptor cDNAs with high efficiency.	calcium phosphate	49-66	complement C5a receptor 1	Homo sapiens	103-115
1525706-0	1992	Inhibition of calcium phosphate precipitation by human salivary statherin: structure-activity relationships.	calcium phosphate	14-31	statherin	Homo sapiens	64-73
1525706-1	1992	Previous studies of human statherin showed the active region for inhibition of secondary calcium phosphate precipitation (crystal growth) to reside in the highly charged amino-terminal one-third of this molecule, and the neutral tyrosine-, glutamine- and proline-rich carboxy-terminal two-thirds of the molecule is required for maximal inhibition of primary (spontaneous) precipitation.	calcium phosphate	89-106	statherin	Homo sapiens	26-35
1818761-1	1991	The hydrolytic conversion of a solid amorphous calcium phosphate of empirical formula Ca9 (PO4)6 to a poorly crystalline apatitic phase, under conditions where Ca2+ and PO4(3-) were conserved, was studied by means of solid-state magic-angle sample spinning 31P-NMR (nuclear magnetic resonance).	calcium phosphate	47-64	carbonic anhydrase 9	Homo sapiens	86-89
2137610-2	1990	SP6-transcribed 32P-labeled U2 small nuclear RNA precursor molecules were introduced into cultured human 293 cells by calcium phosphate-mediated uptake, as in standard DNA transfection experiments.	calcium phosphate	118-135	Sp6 transcription factor	Homo sapiens	0-3
1659545-2	1991	1.7 kb of LH-beta 5" flanking sequence and the first 5 bp of the 5" untranslated region were ligated to the chloramphenicol acetyltransferase (CAT) receptor gene (LH-beta-CAT) and transiently transfected by calcium phosphate precipitation into subconfluent cultures of GH3 cells.	calcium phosphate	207-224	luteinizing hormone subunit beta	Rattus norvegicus	163-170
1713208-2	1991	A stable cell line expressing mouse acetylcholine receptors (AChRs), named AM4, was established by cotransfecting into NIH 3T3 fibroblasts, alpha-, beta-, gamma-, and delta-subunit cDNAs plus the neor gene by calcium phosphate precipitation.	calcium phosphate	209-226	immunoglobulin kappa chain variable 4-72	Mus musculus	75-78
2029541-0	1991	Characterization of phosphopeptide derived from bovine beta-casein: an inhibitor to intra-intestinal precipitation of calcium phosphate.	calcium phosphate	118-135	casein beta	Bos taurus	55-66
2342476-8	1990	The interaction of hARa and hARb with synthetic responsive elements by gel-retardation assay and their responsiveness in trans-activation by calcium phosphate coprecipitation demonstrates that hARb can inhibit trans-activation by hARa in this system.	calcium phosphate	141-158	ATP binding cassette subfamily C member 6	Homo sapiens	19-23
2342476-8	1990	The interaction of hARa and hARb with synthetic responsive elements by gel-retardation assay and their responsiveness in trans-activation by calcium phosphate coprecipitation demonstrates that hARb can inhibit trans-activation by hARa in this system.	calcium phosphate	141-158	ATP binding cassette subfamily C member 6	Homo sapiens	230-234
2004649-4	1991	Calcium phosphate transfection leads to the accumulation of recombinant FN in cytoplasmic vesicles of both matrix-forming and nonforming cells.	calcium phosphate	0-17	fibronectin 1	Homo sapiens	72-74
2117047-1	1990	The expression vector containing the full-length cDNA of human aromatic L-amino acid decarboxylase (EC 4.1.1.28) was transfected in COS cells by a modified calcium phosphate coprecipitation method.	calcium phosphate	156-173	dopa decarboxylase	Homo sapiens	63-98
2218720-3	1990	We now show that mouse Ltk- fibroblasts internalize greater than 90% of radioactively labeled, calcium phosphate-precipitated DNA by a temperature- and energy-dependent process but a small pool of 2-3% of radioactively labeled DNA may be internalized even at 4 degrees C or under energy depletion conditions.	calcium phosphate	95-112	leukocyte tyrosine kinase	Mus musculus	23-26
2138626-4	1990	Lec1 cells were co-transformed with human DNA from A431 cells and eukaryotic expression plasmids containing the bacterial neo gene by calcium phosphate/DNA-mediated transformation.	calcium phosphate	134-151	adhesion G protein-coupled receptor L2	Homo sapiens	0-4
33794402-1	2021	HYPOTHESIS: It has been recently shown that, in our organism, the secretions of Ca2+, Mg2+ and phosphate ions lead to the precipitation of amorphous magnesium-calcium phosphate nanoparticles (AMCPs) in the small intestine, where the glycoprotein mucin is one of the most abundant proteins, being the main component of the mucus hydrogel layer covering gut epithelium.	calcium phosphate	159-176	LOC100508689	Homo sapiens	246-251
33819813-1	2021	This study aimed to fabricate a multi-layered biphasic calcium phosphate (BCP) platform for programmed bone morphogenetic protein-2 (BMP-2) release, which means to block the initial burst release and promote releasing during the differentiation phase of osteogenic cells.	calcium phosphate	55-72	bone morphogenetic protein 2	Homo sapiens	103-131
33819813-1	2021	This study aimed to fabricate a multi-layered biphasic calcium phosphate (BCP) platform for programmed bone morphogenetic protein-2 (BMP-2) release, which means to block the initial burst release and promote releasing during the differentiation phase of osteogenic cells.	calcium phosphate	55-72	bone morphogenetic protein 2	Homo sapiens	133-138
33762629-0	2021	Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics.	calcium phosphate	132-149	bone morphogenetic protein 4	Homo sapiens	17-22
33808198-7	2021	The addition of nanoparticles of amorphous calcium phosphate (NACP) and polyamidoamine dendrimers (PAMAM) resulted in improved remineralization potential.	calcium phosphate	43-60	synuclein alpha	Homo sapiens	62-66
24700504-2	2014	Here, human salivary statherin-inspired genetically engineered recombinamers (ELRs, HSS) on biomedical surfaces regulates mineralization to form an amorphous-calcium-phosphate (ACP) layer that reproduces the original substrate nanotopography.	calcium phosphate	158-175	statherin	Homo sapiens	21-30
33776565-0	2021	FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients.	calcium phosphate	43-60	fibroblast growth factor 23	Homo sapiens	0-5
25583093-2	2015	OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a phosphaturic agent involved in calcium-phosphate homeostasis.	calcium phosphate	83-100	fibroblast growth factor 23	Homo sapiens	11-38
25583093-2	2015	OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a phosphaturic agent involved in calcium-phosphate homeostasis.	calcium phosphate	83-100	fibroblast growth factor 23	Homo sapiens	40-45
34740724-2	2021	Herein, a serum-stable polymer-calcium phosphate (CaP) hybrid nanocapsule carrying siRNA against ADP-ribosylation factor 6 (Arf6) overexpressed in cancer cells and parent drug camptothecin (CPT), designated as PTkCPT/siRNA, was developed for the RNAi-induced oxidative catastrophe and cascaded chemotherapy.	calcium phosphate	31-48	ADP-ribosylation factor 6	Mus musculus	97-122
34699872-5	2022	ADAM17 regulates the renin angiotensin system and together with ADAM10 is involved in calcium phosphate homeostasis.	calcium phosphate	86-103	ADAM metallopeptidase domain 17	Homo sapiens	0-6
34699872-5	2022	ADAM17 regulates the renin angiotensin system and together with ADAM10 is involved in calcium phosphate homeostasis.	calcium phosphate	86-103	ADAM metallopeptidase domain 10	Homo sapiens	64-70
34871957-1	2022	OBJECTIVES: The objective of this study was to develop a novel nanostructured resin infiltrant containing nanoparticles of amorphous calcium phosphate (NACP) to treat enamel white spot lesions (WSLs).	calcium phosphate	133-150	synuclein alpha	Homo sapiens	152-156
34973816-1	2022	The objectives of this in vitro study were to develop a novel low-shrinkage-stress flowable nanocomposite with antibacterial properties through the incorporation of dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and investigate the mechanical and oral biofilm properties, to be used in minimally-invasive techniques.	calcium phosphate	241-258	synuclein alpha	Homo sapiens	260-264
34710761-1	2022	Hydroxyapatite (HAp) is a calcium phosphate material that was used primarily in bone regeneration and repair as a result of its chemical similarity with bone.	calcium phosphate	26-43	reticulon 3	Homo sapiens	16-19
34968725-15	2022	In this paper, we describe a highly selective bio-conjugation of Env trimers to the surface of medically relevant calcium phosphate nanoparticles.	calcium phosphate	114-131	endogenous retrovirus group W member 1, envelope	Homo sapiens	65-68
34740724-2	2021	Herein, a serum-stable polymer-calcium phosphate (CaP) hybrid nanocapsule carrying siRNA against ADP-ribosylation factor 6 (Arf6) overexpressed in cancer cells and parent drug camptothecin (CPT), designated as PTkCPT/siRNA, was developed for the RNAi-induced oxidative catastrophe and cascaded chemotherapy.	calcium phosphate	31-48	ADP-ribosylation factor 6	Mus musculus	124-128
34899951-19	2021	Conclusion: To conclude, the main ingredient of the jintiange capsule, particularly calcium phosphate, may interact with 2 targets, CALR and CALM1, and regulate multiple signaling pathways to treat OP.	calcium phosphate	84-101	calreticulin	Homo sapiens	132-136
34890630-0	2022	Studies on the pH-dependent solubility of various grades of calcium phosphate-based pharmaceutical excipients.	calcium phosphate	60-77	phenylalanine hydroxylase	Homo sapiens	15-17
34899951-18	2021	Molecular docking revealed that the main ingredient, calcium phosphate, had good binding with the CALR protein and CALM1 protein.	calcium phosphate	53-70	calreticulin	Homo sapiens	98-102
34899951-19	2021	Conclusion: To conclude, the main ingredient of the jintiange capsule, particularly calcium phosphate, may interact with 2 targets, CALR and CALM1, and regulate multiple signaling pathways to treat OP.	calcium phosphate	84-101	calmodulin 1	Homo sapiens	141-146
34899951-18	2021	Molecular docking revealed that the main ingredient, calcium phosphate, had good binding with the CALR protein and CALM1 protein.	calcium phosphate	53-70	calmodulin 1	Homo sapiens	115-120
34789268-0	2021	MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer.	calcium phosphate	30-47	CD46 antigen, complement regulatory protein	Mus musculus	0-3
34830316-2	2021	We have previously shown that DC contains both microbial components and calcium phosphate crystals that induce an osteoclastogenic cytokine IL-1beta via the NLRP3 inflammasome in macrophages.	calcium phosphate	72-89	interleukin 1 alpha	Homo sapiens	140-148
34830316-2	2021	We have previously shown that DC contains both microbial components and calcium phosphate crystals that induce an osteoclastogenic cytokine IL-1beta via the NLRP3 inflammasome in macrophages.	calcium phosphate	72-89	NLR family pyrin domain containing 3	Homo sapiens	157-162
34492599-0	2021	Calcium phosphate-polymeric nanoparticle system for co-delivery of microRNA-21 inhibitor and doxorubicin.	calcium phosphate	0-17	microRNA 21	Homo sapiens	67-78
34492599-4	2021	Here, we developed a calcium phosphate (CaP)-coated nanoparticle (NP) formulation to co-deliver miR-21i along with Dox.	calcium phosphate	21-38	microRNA 21	Homo sapiens	96-102
34789268-6	2021	RESULTS: PSVII carboxymethyl-beta-cyclodextrin inclusion compound was successfully encapsulated in colon cancer targeting calcium phosphate nanoparticles (PSVII@MCP-CaP) by using modified citrus pectin as stabilizer agent and colon cancer cell targeting moiety.	calcium phosphate	122-139	CD46 antigen, complement regulatory protein	Mus musculus	155-164
34775641-4	2022	Briefly, glucose oxidase (GOx) is mineralized with manganese-doped calcium phosphate to form GOx@MnCaP nanoparticles, which were encapsulated into the fibrin gel (GOx@MnCaP@fibrin).	calcium phosphate	67-84	hydroxyacid oxidase 1	Homo sapiens	9-24
34775641-4	2022	Briefly, glucose oxidase (GOx) is mineralized with manganese-doped calcium phosphate to form GOx@MnCaP nanoparticles, which were encapsulated into the fibrin gel (GOx@MnCaP@fibrin).	calcium phosphate	67-84	hydroxyacid oxidase 1	Homo sapiens	26-29
34775641-4	2022	Briefly, glucose oxidase (GOx) is mineralized with manganese-doped calcium phosphate to form GOx@MnCaP nanoparticles, which were encapsulated into the fibrin gel (GOx@MnCaP@fibrin).	calcium phosphate	67-84	hydroxyacid oxidase 1	Homo sapiens	93-96
34775641-4	2022	Briefly, glucose oxidase (GOx) is mineralized with manganese-doped calcium phosphate to form GOx@MnCaP nanoparticles, which were encapsulated into the fibrin gel (GOx@MnCaP@fibrin).	calcium phosphate	67-84	hydroxyacid oxidase 1	Homo sapiens	163-166
34266365-4	2021	When integrated with inorganic components such as calcium phosphate, ADM could be transformed to bone graft substitutes with desirable osteogenic properties.	calcium phosphate	50-67	adrenomedullin	Homo sapiens	69-72
34649197-3	2021	The nanoplatform was synthesized through the spontaneous biomineralization of glucose oxidase (GOx) and metformin in amorphous calcium phosphate nanosubstrate, which was further modified with polyethylene glycol and cRGD ligands.	calcium phosphate	127-144	hydroxyacid oxidase 1	Homo sapiens	78-93
34649197-3	2021	The nanoplatform was synthesized through the spontaneous biomineralization of glucose oxidase (GOx) and metformin in amorphous calcium phosphate nanosubstrate, which was further modified with polyethylene glycol and cRGD ligands.	calcium phosphate	127-144	hydroxyacid oxidase 1	Homo sapiens	95-98
34732247-7	2021	In contrast, relatively low dietary calcium phosphate levels promoted the abundance of mucin degrading genera like Akkermansia and Bacteroides, and resulted in increased fecal propionic acid levels and modest increases in lactic and butyric acid levels.	calcium phosphate	36-53	solute carrier family 13 member 2	Rattus norvegicus	87-92
34554637-2	2021	Herein, an amorphous calcium phosphate (ACP)-based nanoplatform is reported for the targeted combinational ferroptosis/apoptosis therapy of drug resistant tumor cells by blocking the MCT4-mediated efflux of lactic acid (LA).	calcium phosphate	21-38	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	183-187
34815800-2	2021	However, these nanoreactors, including mesoporous silica, calcium phosphate, metal-organic framework, or polymer nanocarriers, cannot completely block the reaction of GOx with glucose in the blood, inducing systemic toxicity from hydrogen peroxide (H2O2) and anoxia.	calcium phosphate	58-75	hydroxyacid oxidase 1, liver	Mus musculus	167-170
34770985-0	2021	Synergistic Effect of Biphasic Calcium Phosphate and Platelet-Rich Fibrin Attenuate Markers for Inflammation and Osteoclast Differentiation by Suppressing NF-kappaB/MAPK Signaling Pathway in Chronic Periodontitis.	calcium phosphate	31-48	nuclear factor kappa B subunit 1	Homo sapiens	155-164
34770985-3	2021	It is stated that that biphasic calcium phosphate (BCP) and platelet-rich fibrin (PRF) have significant antiostoeclastogenic effects in chronic periodontitis.	calcium phosphate	32-49	opsin 1, short wave sensitive	Homo sapiens	51-54
34252802-0	2021	Silica-coated calcium phosphate nanoparticles for gene silencing of NF-kappaB p65 by siRNA and their impact on cellular players of inflammation.	calcium phosphate	14-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	68-81
34364122-8	2021	The increase in superoxide dismutase, peroxidase and, catalase activity by the combined application of TiO2 NPs and calcium phosphate was 83% and 78%, 74% and 52%, 81%, and 67% in Pakistan-13 and Zincol-16 respectively, as compared to untreated drought exposed plants.	calcium phosphate	116-133	catalase	Homo sapiens	54-62
34581961-3	2021	To circumvent these obstacles, we constructed a self-biomineralized adenovirus vectored COVID-19 vaccine (Sad23L-nCoV-S-CaP) by generating a calcium phosphate mineral exterior (CaP) based on Sad23L vector carrying the full-length gene of SARS-CoV-2 spike protein (S) under physiological condition.	calcium phosphate	141-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	249-254
34650342-1	2021	Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in diverse biological processes, including regulation of calcium phosphate homeostasis, cell proliferation, apoptosis, inflammation, oxidative stress responses, and cancer development.	calcium phosphate	116-133	stanniocalcin 1	Homo sapiens	0-15
34650342-1	2021	Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in diverse biological processes, including regulation of calcium phosphate homeostasis, cell proliferation, apoptosis, inflammation, oxidative stress responses, and cancer development.	calcium phosphate	116-133	stanniocalcin 1	Homo sapiens	17-22
34062235-3	2021	RESULTS: A hybrid nanocarrier composed of calcium phosphate as the inorganic phase and a block copolymer containing polyanions as organic phase, named HNPs, was developed to deliver VEGF siRNA into metastatic breast cancer in mice.	calcium phosphate	42-59	vascular endothelial growth factor A	Mus musculus	182-186
34465809-5	2021	Transgenic overexpression of the human KAL gene (KS-Tg) or administration of recombinant human KAL (rhKAL) inhibited AAA in the calcium phosphate (CaPO4) and subcutaneous angiotensin II (AngII) infusion mouse models.	calcium phosphate	128-145	serpin family A member 4	Homo sapiens	39-42
34474857-2	2021	This study developed for the first time a calcium phosphate cement (CPC) for delivery of doxycycline (DOX) and human platelet lysate (hPL) to fight against S. aureus infection and enhance the osteogenesis of human periodontal ligament stem cells (hPDLSCs).	calcium phosphate	42-59	galectin 1	Homo sapiens	134-137
34581165-2	2021	PAM is described as the formation and accumulation of calcium phosphate microliths in the alveoli after mutations in the SLC34A2 gene.	calcium phosphate	54-71	solute carrier family 34 member 2	Homo sapiens	121-128
34465809-5	2021	Transgenic overexpression of the human KAL gene (KS-Tg) or administration of recombinant human KAL (rhKAL) inhibited AAA in the calcium phosphate (CaPO4) and subcutaneous angiotensin II (AngII) infusion mouse models.	calcium phosphate	128-145	serpin family A member 4	Homo sapiens	95-98
34185705-6	2021	Once it exceeded a threshold, microscopic particles containing calcium phosphate crystals appeared in the tubular lumen, which damaged tubular cells through binding to Toll-like receptor-4 expressed on them.	calcium phosphate	63-80	toll like receptor 4	Homo sapiens	168-188
34308944-2	2021	Herein, glucose oxidase (GOx) and Fe3O4/TiO2/Ag3PO4 were embedded in a polyacrylic acid-calcium phosphate (PAA-CaPs@Nps@GOx) hydrogel through an in situ biomimetic mineralization approach.	calcium phosphate	88-105	hydroxyacid oxidase 1	Homo sapiens	8-23
34308944-2	2021	Herein, glucose oxidase (GOx) and Fe3O4/TiO2/Ag3PO4 were embedded in a polyacrylic acid-calcium phosphate (PAA-CaPs@Nps@GOx) hydrogel through an in situ biomimetic mineralization approach.	calcium phosphate	88-105	hydroxyacid oxidase 1	Homo sapiens	25-28
34308944-2	2021	Herein, glucose oxidase (GOx) and Fe3O4/TiO2/Ag3PO4 were embedded in a polyacrylic acid-calcium phosphate (PAA-CaPs@Nps@GOx) hydrogel through an in situ biomimetic mineralization approach.	calcium phosphate	88-105	hydroxyacid oxidase 1	Homo sapiens	120-123
34396990-5	2021	Calcium phosphate crystals attached to TLR4 and underwent endocytosis at the brush border, triggering inflammation and fibrosis.	calcium phosphate	0-17	toll like receptor 4	Homo sapiens	39-43
34549337-1	2021	Localization of PCNA, CD44, osteocalcin, Mdm2, p53, and caspase-3 on the surface of implant with calcium phosphate and hydroxyapatite coating was studied by immunocytochemical method in a model of femur fracture in rats.	calcium phosphate	97-114	proliferating cell nuclear antigen	Rattus norvegicus	16-20
34374422-7	2021	In the blood, calcium-phosphate precipitated upon increase in the blood phosphate concentration is adsorbed by serum protein fetuin-A to form colloidal nanoparticles called calciprotein particles (CPPs).	calcium phosphate	14-31	alpha-2-HS-glycoprotein	Mus musculus	125-133
34392408-1	2022	OBJECTIVES: A previous study showed that the combination of poly(amido amine) (PAMAM) and rechargeable composites with nanoparticles of amorphous calcium phosphate (NACP) induced dentin remineralization in an acidic solution with no initial calcium (Ca) and phosphate (P) ions, mimicking the oral condition of individuals with dry mouths.	calcium phosphate	146-163	synuclein alpha	Homo sapiens	165-169
34441870-2	2021	The study aimed to assess serum sclerostin concentration and its relationship with blood pressure, arterial damage, and calcium-phosphate metabolism in children and adolescents with primary hypertension (PH).	calcium phosphate	120-137	sclerostin	Homo sapiens	32-42
34549337-1	2021	Localization of PCNA, CD44, osteocalcin, Mdm2, p53, and caspase-3 on the surface of implant with calcium phosphate and hydroxyapatite coating was studied by immunocytochemical method in a model of femur fracture in rats.	calcium phosphate	97-114	CD44 molecule (Indian blood group)	Rattus norvegicus	22-26
34549337-1	2021	Localization of PCNA, CD44, osteocalcin, Mdm2, p53, and caspase-3 on the surface of implant with calcium phosphate and hydroxyapatite coating was studied by immunocytochemical method in a model of femur fracture in rats.	calcium phosphate	97-114	caspase 3	Rattus norvegicus	56-65
34110599-2	2021	In the present study, we examined the in vitro effects of LIF on osteoblast differentiation of bone marrow stem cells (BMSCs) and explored in vivo effects of LIF on the bone repair capacity of BMSCs-loaded biphasic calcium phosphate (BCP) scaffolds in mouse calvarial bone defect model.	calcium phosphate	215-232	leukemia inhibitory factor	Mus musculus	158-161
34117838-1	2021	The aim of the current study is to assess the biological performance of self-healing hydrogels based on calcium phosphate (CaP) nanoparticles and bisphosphonate (BP) conjugated hyaluronan (HA) in a critical size segmental femoral bone defect model in rats.	calcium phosphate	104-121	sorbin and SH3 domain containing 1	Rattus norvegicus	123-126
34300255-12	2021	On the other hand, FGF-23 can represent a parameter reflecting the degree of calcium-phosphate imbalance in PHPT patients, but its usefulness in monitoring the effects of PTX requires further research.	calcium phosphate	77-94	fibroblast growth factor 23	Homo sapiens	19-25
35549335-5	2022	Subsequently, calcium phosphate nanoparticles (CAPs) are generated by the reaction between the released Ca2+ from LDH degradation and endogenous phosphates, resulting in M2 phenotype anti-inflammatory differentiation of bone macrophages through a c-Maf transcriptional factor pathway and the following activity enhancements of regulatory T cells (Treg) and the deactivation of T helper 17 cells (TH17).	calcium phosphate	14-31	MAF bZIP transcription factor	Homo sapiens	247-252
34279263-0	2021	Amorphous-Crystalline Calcium Phosphate Coating Promotes In Vitro Growth of Tumor-Derived Jurkat T Cells Activated by Anti-CD2/CD3/CD28 Antibodies.	calcium phosphate	22-39	CD2 molecule	Homo sapiens	123-126
34279263-0	2021	Amorphous-Crystalline Calcium Phosphate Coating Promotes In Vitro Growth of Tumor-Derived Jurkat T Cells Activated by Anti-CD2/CD3/CD28 Antibodies.	calcium phosphate	22-39	CD28 molecule	Homo sapiens	131-135
34279263-7	2021	A decrease in the ZP magnitudes of CaP coatings deposited at 200-250 V was strongly associated with elevated hTERT expression in tumor-derived Jurkat T cells preliminarily activated with anti-CD2/CD3/CD28 antibodies and then contacted in vitro with CaP-coated samples for 14 days.	calcium phosphate	35-38	telomerase reverse transcriptase	Homo sapiens	109-114
34279263-7	2021	A decrease in the ZP magnitudes of CaP coatings deposited at 200-250 V was strongly associated with elevated hTERT expression in tumor-derived Jurkat T cells preliminarily activated with anti-CD2/CD3/CD28 antibodies and then contacted in vitro with CaP-coated samples for 14 days.	calcium phosphate	35-38	CD2 molecule	Homo sapiens	192-195
34279263-7	2021	A decrease in the ZP magnitudes of CaP coatings deposited at 200-250 V was strongly associated with elevated hTERT expression in tumor-derived Jurkat T cells preliminarily activated with anti-CD2/CD3/CD28 antibodies and then contacted in vitro with CaP-coated samples for 14 days.	calcium phosphate	35-38	CD28 molecule	Homo sapiens	200-204
34078994-2	2021	Room-temperature phosphorylation and subsequent calcination produce pure HAp via intermediate amorphous calcium phosphate (ACP).	calcium phosphate	104-121	reticulon 3	Homo sapiens	73-76
35417664-4	2022	Intracellular Lyso-PAF promotes p21-activated kinase 2 (PAK2) activation by binding to its catalytic domain and altering ATP kinetics, while PAK2 significantly contributes to S338-phosphorylation of RAF1 in addition to PAK1.	calcium phosphate	175-179	p21 (RAC1) activated kinase 2	Mus musculus	141-145
35417664-4	2022	Intracellular Lyso-PAF promotes p21-activated kinase 2 (PAK2) activation by binding to its catalytic domain and altering ATP kinetics, while PAK2 significantly contributes to S338-phosphorylation of RAF1 in addition to PAK1.	calcium phosphate	175-179	v-raf-leukemia viral oncogene 1	Mus musculus	199-203
35312270-5	2022	In addition, a systematic investigation into cell viability, ALP activity, and cell morphology confirmed that the Ca-P coating had excellent biocompatibility, which could effectively promote the proliferation, differentiation, and adhesion of osteoblasts.	calcium phosphate	114-118	ATHS	Homo sapiens	61-64
35591682-0	2022	PCL/Si-Doped Multi-Phase Calcium Phosphate Scaffolds Derived from Cuttlefish Bone.	calcium phosphate	25-42	PHD finger protein 1	Homo sapiens	0-3
35574049-4	2023	In this study, a regenerative scaffold regulating the macrophage immune microenvironment and promoting bone regeneration in a dual-stage process for the postoperative treatment of bone tumors was constructed by binding a colony-stimulating factor 1 receptor (CSF-1R) inhibitor GW2580 onto in situ cosslinked hydroxybutylchitosan (HBC)/oxidized chondroitin sulfate (OCS) hydrogel layer covering a 3D printed calcium phosphate scaffold based on electrostatic interaction.	calcium phosphate	407-424	colony stimulating factor 1 receptor	Homo sapiens	221-257
35574049-4	2023	In this study, a regenerative scaffold regulating the macrophage immune microenvironment and promoting bone regeneration in a dual-stage process for the postoperative treatment of bone tumors was constructed by binding a colony-stimulating factor 1 receptor (CSF-1R) inhibitor GW2580 onto in situ cosslinked hydroxybutylchitosan (HBC)/oxidized chondroitin sulfate (OCS) hydrogel layer covering a 3D printed calcium phosphate scaffold based on electrostatic interaction.	calcium phosphate	407-424	colony stimulating factor 1 receptor	Homo sapiens	259-265
35442639-4	2022	The nanoplatform is constructed by employing mesoporous polydopamine nanoparticles (MPDA NPs) with surface modification of amines as the porous core for TNF-alpha-siRNA loading (31 wt %) and exerts an antioxidant function, while PDA-induced biomineralization of the calcium phosphate (CaP) coating is used as the pH-sensitive protective shell to prevent siRNA from premature release.	calcium phosphate	266-283	tumor necrosis factor	Homo sapiens	153-162
35530975-1	2022	Purpose: This study aimed to construct a delivery system based on L-arginine-modified calcium phosphate (CaP) to load eNOS plasmids (peNOS), which could amply nitric oxide (NO) to repair endothelial damage, promote angiogenic activities and alleviate inflammation.	calcium phosphate	86-103	nitric oxide synthase 3, endothelial cell	Mus musculus	118-122
35530975-1	2022	Purpose: This study aimed to construct a delivery system based on L-arginine-modified calcium phosphate (CaP) to load eNOS plasmids (peNOS), which could amply nitric oxide (NO) to repair endothelial damage, promote angiogenic activities and alleviate inflammation.	calcium phosphate	105-108	nitric oxide synthase 3, endothelial cell	Mus musculus	118-122
35453486-7	2022	Adhesives containing calcium phosphate and silicate were both cytocompatible for seven days in direct contact with cell monolayers, and ion release increased the alkaline phosphatase (ALP) activity in odontoblasts, but not pre-osteoblasts.	calcium phosphate	21-38	alkaline phosphatase, placental	Homo sapiens	162-182
35453486-7	2022	Adhesives containing calcium phosphate and silicate were both cytocompatible for seven days in direct contact with cell monolayers, and ion release increased the alkaline phosphatase (ALP) activity in odontoblasts, but not pre-osteoblasts.	calcium phosphate	21-38	alkaline phosphatase, placental	Homo sapiens	184-187
35216422-1	2022	Arterial calcification is a common feature of pseudoxanthoma elasticum (PXE), a disease characterized by ABCC6 mutations, inducing a deficiency in pyrophosphate, a key inhibitor of calcium phosphate crystallization in arteries.	calcium phosphate	181-198	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Mus musculus	105-110
35085700-3	2022	To downregulate HIF-1alpha, NF-kappaB, and MAPK expression, we proposed HIF-1alpha siRNA-loaded calcium phosphate nanoparticles encapsulated in apolipoprotein E3-reconstituted high-density lipoprotein (HIF-CaP-rHDL) for RA therapy.	calcium phosphate	96-113	hypoxia inducible factor 1, alpha subunit	Mus musculus	16-26
35085700-3	2022	To downregulate HIF-1alpha, NF-kappaB, and MAPK expression, we proposed HIF-1alpha siRNA-loaded calcium phosphate nanoparticles encapsulated in apolipoprotein E3-reconstituted high-density lipoprotein (HIF-CaP-rHDL) for RA therapy.	calcium phosphate	96-113	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	28-37
35085700-3	2022	To downregulate HIF-1alpha, NF-kappaB, and MAPK expression, we proposed HIF-1alpha siRNA-loaded calcium phosphate nanoparticles encapsulated in apolipoprotein E3-reconstituted high-density lipoprotein (HIF-CaP-rHDL) for RA therapy.	calcium phosphate	96-113	hypoxia inducible factor 1, alpha subunit	Mus musculus	72-82
35159282-1	2022	Mesenchymal stromal cells (MSC) loaded on biphasic calcium phosphate biomaterial (MSC + BCP) have been used as an advanced therapy medicinal product to treat complex maxillofacial bone defects in patients.	calcium phosphate	51-68	musculin	Homo sapiens	82-85
35386349-0	2022	CD301b+ macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis.	calcium phosphate	44-61	nuclear factor of activated T cells 1	Homo sapiens	81-87
35386349-0	2022	CD301b+ macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis.	calcium phosphate	44-61	vascular endothelial growth factor A	Homo sapiens	88-92
35072831-0	2022	Loading of erythropoietin on biphasic calcium phosphate bioceramics promotes osteogenesis and angiogenesis by regulating EphB4/EphrinB2 molecules.	calcium phosphate	38-55	erythropoietin	Rattus norvegicus	11-25
35068157-7	2022	Furthermore, through monitoring the pH change in bulk mineralization solution, we tracked the nucleation behavior of HAP in the presence of Ambn and Amel and found that their coassemblies at different ratios showed varying abilities to stabilize amorphous calcium phosphate.	calcium phosphate	256-273	ameloblastin	Mus musculus	140-144
35068157-7	2022	Furthermore, through monitoring the pH change in bulk mineralization solution, we tracked the nucleation behavior of HAP in the presence of Ambn and Amel and found that their coassemblies at different ratios showed varying abilities to stabilize amorphous calcium phosphate.	calcium phosphate	256-273	amelogenin, X-linked	Mus musculus	149-153
35072831-0	2022	Loading of erythropoietin on biphasic calcium phosphate bioceramics promotes osteogenesis and angiogenesis by regulating EphB4/EphrinB2 molecules.	calcium phosphate	38-55	EPH receptor B4	Rattus norvegicus	121-126
35072831-0	2022	Loading of erythropoietin on biphasic calcium phosphate bioceramics promotes osteogenesis and angiogenesis by regulating EphB4/EphrinB2 molecules.	calcium phosphate	38-55	ephrin B2	Rattus norvegicus	127-135
35072831-3	2022	In this study, we grafted polydopamine and EPO onto the surface of biphasic calcium phosphate.	calcium phosphate	76-93	erythropoietin	Rattus norvegicus	43-46
35072831-10	2022	Overall, our findings demonstrated that EPO loading on biphasic calcium phosphate bioceramics could promote both osteogenesis and angiogenesis.	calcium phosphate	64-81	erythropoietin	Rattus norvegicus	40-43
35054772-9	2022	In conclusion, CXCL4 and CXCL4L1 both modulate gene expression, yet only CXCL4 increases the division rate and formation of calcium-phosphate crystals in VSMCs.	calcium phosphate	124-141	platelet factor 4	Homo sapiens	15-20
35052802-1	2022	INTRODUCTION: Primary hyperparathyroidism (PHPT) is a condition characterized by disorders of calcium-phosphate metabolism and bone metabolism caused by pathological overproduction of parathyroid hormone (PTH).	calcium phosphate	94-111	parathyroid hormone	Homo sapiens	184-203
35052802-1	2022	INTRODUCTION: Primary hyperparathyroidism (PHPT) is a condition characterized by disorders of calcium-phosphate metabolism and bone metabolism caused by pathological overproduction of parathyroid hormone (PTH).	calcium phosphate	94-111	parathyroid hormone	Homo sapiens	205-208
35054772-9	2022	In conclusion, CXCL4 and CXCL4L1 both modulate gene expression, yet only CXCL4 increases the division rate and formation of calcium-phosphate crystals in VSMCs.	calcium phosphate	124-141	platelet factor 4 variant 1	Homo sapiens	25-32
35054772-9	2022	In conclusion, CXCL4 and CXCL4L1 both modulate gene expression, yet only CXCL4 increases the division rate and formation of calcium-phosphate crystals in VSMCs.	calcium phosphate	124-141	platelet factor 4	Homo sapiens	73-78
2613439-0	1989	Complete primary structure of statherin, a potent inhibitor of calcium phosphate precipitation, from the saliva of the monkey, Macaca arctoides.	calcium phosphate	63-80	statherin	Homo sapiens	30-39
2626897-1	1989	CHO cells were transfected with plasmid pSV2-PDGF-A (containing human PDGF-A cDNA) by calcium phosphate method.	calcium phosphate	86-103	platelet derived growth factor subunit A	Homo sapiens	70-76
35224165-3	2022	Although TRPC3 knockout (-/-) mice were mildly hypercalciuric and displayed luminal calcium phosphate (CaP) crystals at Loop of Henle (LOH), no CaP + calcium oxalate (CaOx) mixed urine crystals were spotted, which are mostly found in calcium nephrolithiasis (CaNL).	calcium phosphate	103-106	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	9-14
2549810-1	1989	Osteocalcin, a major noncollagenous matrix protein of bone, dentin, and cementum, is found in tight association with the calcium phosphate mineral phase of these tissues.	calcium phosphate	121-138	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
2506442-0	1989	Calcium phosphate-mediated transfection alters metallothionein gene expression in response to Cd2+ and Zn2+.	calcium phosphate	0-17	CD2 molecule	Homo sapiens	94-97
3057238-3	1988	Calcium phosphate mediated DNA transfections of AT2.1 cells were performed with the v-H-ras oncogene or with control DNA.	calcium phosphate	0-17	HRas proto-oncogene, GTPase	Rattus norvegicus	86-91
2637370-2	1989	The effect of the phosphorylated protein, phosvitin, on the formation of the calcium phosphate crystal was examined in metastable calcium phosphate solution.	calcium phosphate	77-94	casein kinase 2 beta	Homo sapiens	42-51
2637370-2	1989	The effect of the phosphorylated protein, phosvitin, on the formation of the calcium phosphate crystal was examined in metastable calcium phosphate solution.	calcium phosphate	130-147	casein kinase 2 beta	Homo sapiens	42-51
3126553-2	1988	The frequency of transfection for XUM1 cells after exposure to calcium phosphate-coprecipitated pSV2neo DNA was more than 10(4)-fold less effective than that for Ltk-aprt- (LTA) cells.	calcium phosphate	63-80	leukocyte tyrosine kinase	Mus musculus	162-165
3389734-3	1988	Using the calcium phosphate transfection method, we found that the oligonucleotide was very stable compared to the levels reported to be induced by IFN.	calcium phosphate	10-27	interferon alpha 1	Homo sapiens	148-151
2855426-2	1988	Inhibition of seeded crystal growth of hydroxyapatite in metastable calcium phosphate solution by fibronectin].	calcium phosphate	68-85	fibronectin 1	Homo sapiens	98-109
2903152-3	1988	A 2.6-kilobase EcoRI fragment of the human GH gene was propagated in pUC18 and transfected by calcium-phosphate shock into HeLa and GC cells, respectively.	calcium phosphate	94-111	growth hormone 1	Homo sapiens	43-45
3395976-6	1988	Our results showed that the fibroblasts and macrophagous++ cells interaction with the calcium phosphate crystal (B-TCP and HAP) was more important in the experiments with a fibronectin bilayer.	calcium phosphate	86-103	fibronectin 1	Homo sapiens	173-184
3035774-4	1987	Crystalluria and stone analysis support the assumption that the physico-chemical environment accompanied by low gastrin levels predisposes to urinary precipitation of calcium phosphate with subsequent formation of a stone nidus.	calcium phosphate	167-184	gastrin	Homo sapiens	112-119
3476566-2	1987	The major acidic proline-rich proteins and the proline-rich phosphopeptide, statherin, of man and macaques have been shown to be potent inhibitors of calcium phosphate precipitation and are thought to function in the oral environment by maintaining saliva supersaturated with respect to calcium phosphate salts.	calcium phosphate	150-167	statherin	Homo sapiens	76-85
2829251-1	1987	We have shown that when pSV2-gpt is introduced into human cells by calcium phosphate coprecipitation, the yield of Gpt+ transformants is increased by irradiating the plasmid with 254 nm uv.	calcium phosphate	67-84	glutamic--pyruvic transaminase	Homo sapiens	29-32
2829251-1	1987	We have shown that when pSV2-gpt is introduced into human cells by calcium phosphate coprecipitation, the yield of Gpt+ transformants is increased by irradiating the plasmid with 254 nm uv.	calcium phosphate	67-84	glutamic--pyruvic transaminase	Homo sapiens	115-118
3679674-0	1987	Chemical synthesis of phosphoseryl-phosphoserine, a partial analogue of human salivary statherin, a protein inhibitor of calcium phosphate precipitation in human saliva.	calcium phosphate	121-138	statherin	Homo sapiens	87-96
3116409-2	1987	HIG1 gene and its recombinant plasmids were transfected by the calcium phosphate method into 70Z/3 cells and the cells were stimulated with lipopolysaccharide (LPS) 48 hr after DNA transfection.	calcium phosphate	63-80	HIG1 domain family, member 1A	Mus musculus	0-4
3035774-5	1987	pH in fasting urine and integrated fasting serum gastrin correlate significantly, suggesting that low fasting serum gastrin in RCU patients may be considered a risk factor for calcium phosphate stone formation.	calcium phosphate	176-193	gastrin	Homo sapiens	116-123
3604153-4	1987	Calcium phosphate adsorbed preparations contain less VIII:CAg than the DEAE-Sephadex-prepared fractions.	calcium phosphate	0-17	cytochrome c oxidase subunit 8A	Homo sapiens	53-57
3753476-2	1986	The effect of dentin phosphoprotein (DPP) over a wide concentration range on precipitation and crystallization of calcium phosphate was studied in supersaturated solutions at pH 7.8 and 25 degrees C with a gel matrix model.	calcium phosphate	114-131	dentin sialophosphoprotein	Sus scrofa	14-35
3014525-1	1986	A transforming DNA, named lca (for liver cancer), was obtained from a primary human hepatocellular carcinoma (HCC) in transformation assays using NIH 3T3 cells and a calcium phosphate coprecipitation method.	calcium phosphate	166-183	clathrin light chain A	Homo sapiens	26-29
3710693-0	1986	Complete covalent structure of a proline-rich phosphoprotein, PRP-2, an inhibitor of calcium phosphate crystal growth from human parotid saliva.	calcium phosphate	85-102	transmembrane protein 171	Homo sapiens	62-67
3701327-8	1986	The decreased solubility of zinc in skimmed milks in pH"s characteristic of the small intestine is likely due to coprecipitation of zinc with calcium phosphate--a reaction not predicted for milk systems from known chemical solubility product data.	calcium phosphate	142-159	Weaning weight-maternal milk	Bos taurus	44-48
3022136-3	1986	Calcium phosphate-mediated transfer of minigene DNA into DHFR gene-deleted Chinese hamster ovary cells converted these cells to a DHFR+ phenotype at a frequency of 0.12%.	calcium phosphate	0-17	dihydrofolate reductase	Cricetulus griseus	57-61
3022136-3	1986	Calcium phosphate-mediated transfer of minigene DNA into DHFR gene-deleted Chinese hamster ovary cells converted these cells to a DHFR+ phenotype at a frequency of 0.12%.	calcium phosphate	0-17	dihydrofolate reductase	Cricetulus griseus	130-134
3733697-2	1986	The transient expression of the apo-E gene was examined in cultured mammalian cells 48 h following calcium phosphate-mediated gene transfer.	calcium phosphate	99-116	apolipoprotein E	Homo sapiens	32-37
3753476-2	1986	The effect of dentin phosphoprotein (DPP) over a wide concentration range on precipitation and crystallization of calcium phosphate was studied in supersaturated solutions at pH 7.8 and 25 degrees C with a gel matrix model.	calcium phosphate	114-131	dentin sialophosphoprotein	Sus scrofa	37-40
3920222-6	1985	Other competence-inducing factors (fibroblast growth factor, calcium phosphate, and choleragen) and tumor growth factor produced similar alterations in vinculin and actin distribution as did PDGF, though not to the same extent.	calcium phosphate	61-78	vinculin	Mus musculus	152-160
2993008-1	1985	The influence of inhibitors of the enzyme ADP-Ribosyl Transferase (ADPRT) upon the morphological transformation of NIH3T3 cells by calcium phosphate-SV40 DNA co-precipitates was examined.	calcium phosphate	131-148	ADP-ribosyltransferase 1	Mus musculus	42-65
2993008-1	1985	The influence of inhibitors of the enzyme ADP-Ribosyl Transferase (ADPRT) upon the morphological transformation of NIH3T3 cells by calcium phosphate-SV40 DNA co-precipitates was examined.	calcium phosphate	131-148	ADP-ribosyltransferase 1	Mus musculus	67-72
3990689-2	1985	A family of plasmids with insertion and deletion mutations in the coding region of the herpes simplex type 1 thymidine kinase (tk) gene served as substrates for DNA-mediated gene transfer into mouse Ltk- cells by the calcium phosphate technique.	calcium phosphate	217-234	leukocyte tyrosine kinase	Mus musculus	199-202
3990691-1	1985	An aryl hydrocarbon hydroxylase (AHH)-deficient gene A- mutant of the mouse line Hepa-1 was treated with calcium phosphate precipitates of DNA from Hepa-1, the rat line H4IIEC3, or an A- -human hybrid in which the A- mutation is complemented by the corresponding human gene.	calcium phosphate	105-122	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	3-31
3990691-1	1985	An aryl hydrocarbon hydroxylase (AHH)-deficient gene A- mutant of the mouse line Hepa-1 was treated with calcium phosphate precipitates of DNA from Hepa-1, the rat line H4IIEC3, or an A- -human hybrid in which the A- mutation is complemented by the corresponding human gene.	calcium phosphate	105-122	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-36
3838796-1	1985	A recombinant plasmid containing a full-length cDNA for hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase was introduced by calcium phosphate-mediated transfection into UT-2 cells, a mutant line of Chinese hamster ovary cells that lack 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and thus require low density lipoprotein-cholesterol and mevalonate for growth.	calcium phosphate	130-147	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	64-111
3972817-1	1985	Chicken glyceraldehyde-3-phosphate dehydrogenase gene (GAPD) and thymidine kinase gene (TK) were co-transfected into mouse LMTK- cells by the calcium phosphate precipitation technique.	calcium phosphate	142-159	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	8-48
6100386-3	1984	Recombinants carrying the human beta, delta and epsilon globin genes covalently linked to the aph gene have been introduced into these K562 cells using the calcium phosphate technique.	calcium phosphate	156-173	hemoglobin subunit beta	Homo sapiens	32-62
3922899-9	1985	The latter reactions may manifest themselves in the inhibition of spontaneous precipitation of calcium phosphate; thus these polyols may mimic the function of innate inhibitors, statherin, for example.	calcium phosphate	95-112	statherin	Homo sapiens	178-187
6330533-1	1984	Irradiating the plasmid pSV2-gpt with UV (254 nm) doses up to 200 J m-2 caused a dose-dependent increase in the yield of Gpt+ transformants when the plasmid was introduced into human cells by calcium phosphate coprecipitation.	calcium phosphate	192-209	glutamic--pyruvic transaminase	Homo sapiens	29-32
6330533-1	1984	Irradiating the plasmid pSV2-gpt with UV (254 nm) doses up to 200 J m-2 caused a dose-dependent increase in the yield of Gpt+ transformants when the plasmid was introduced into human cells by calcium phosphate coprecipitation.	calcium phosphate	192-209	glutamic--pyruvic transaminase	Homo sapiens	121-124
6429216-0	1984	Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva.	calcium phosphate	81-98	statherin	Homo sapiens	53-62
6818555-2	1982	Plasmid pSV2gpt-kappa 41, containing the kappa light chain gene from the myeloma MOPC41 and the selectable marker gene gpt, was introduced into 81A-2 cells by the calcium phosphate coprecipitation technique.	calcium phosphate	163-180	glutamic pyruvic transaminase, soluble	Mus musculus	12-15
6314276-8	1983	When recombinants are introduced into eukaryotic cells by either calcium phosphate coprecipitation or protoplast fusion, expression of chicken ovalbumin or conalbumin may be detected by indirect immunofluorescence.	calcium phosphate	65-82	ovalbumin (SERPINB14)	Gallus gallus	143-152
6314276-8	1983	When recombinants are introduced into eukaryotic cells by either calcium phosphate coprecipitation or protoplast fusion, expression of chicken ovalbumin or conalbumin may be detected by indirect immunofluorescence.	calcium phosphate	65-82	transferrin (ovotransferrin)	Gallus gallus	156-166
6615980-0	1983	Activation of complement C3 by different calcium phosphate powders.	calcium phosphate	41-58	complement C3	Homo sapiens	14-27
6615980-1	1983	The ability of different calcium phosphate to activate the complement system is studied by crossed immunoelectrophoresis demonstrating conversion of C3 to C3b.	calcium phosphate	25-42	complement C3	Homo sapiens	155-158
6884154-2	1983	Wild-type mouse LtAp20 cells were treated with calcium phosphate-precipitated DNA or chromosomes from two highly Methotrexate (MTX)-resistant mouse lymphoma cell lines--EL4/8 and EL4/11.	calcium phosphate	47-64	lymphotoxin A	Mus musculus	16-20
6884154-2	1983	Wild-type mouse LtAp20 cells were treated with calcium phosphate-precipitated DNA or chromosomes from two highly Methotrexate (MTX)-resistant mouse lymphoma cell lines--EL4/8 and EL4/11.	calcium phosphate	47-64	epilepsy 4	Mus musculus	179-185
6192322-9	1983	This work demonstrated that the role of dsRNA in regulating the antiviral and anticellular activities of IFN could be studied by introducing exogenous dsRNA into cells in culture by the calcium phosphate coprecipitation technique.	calcium phosphate	186-203	interferon alpha 1	Homo sapiens	105-108
6328272-4	1984	When lambda tk2 DNA was transferred into mouse LMtk- cells by the calcium phosphate method, rare TK+ transformants were obtained that contained many (greater than 40) copies of the unrecombined DNA.	calcium phosphate	66-83	thymidine kinase 2, mitochondrial	Mus musculus	12-15
6423238-7	1984	Precipitation studies showed that 0.5 M xylitol and 0.5 M sorbitol significantly retarded the formation of calcium phosphate precipitates from a solution of Ca(II) and phosphate, compared with the effect caused by glucose, sorbose, or xylose.	calcium phosphate	107-124	carbonic anhydrase 2	Homo sapiens	157-163
6141115-1	1984	After having reviewed the properties of calcitonin (Ct), a hormone involved in calcium-phosphate metabolism and bone turnover, mention is made of the effects of Ct at the level of the CNS and its role as a neuromediator interfering with endorphins, prolactin, dopamine and the Ca concentration of the CSF.	calcium phosphate	79-96	calcitonin related polypeptide alpha	Homo sapiens	40-50
6675525-0	1983	Calcium-phosphate-adjuvanted allergens: total and specific IgE levels before and after immunotherapy with house dust and Dermatophagoides pteronyssinus extracts.	calcium phosphate	0-17	immunoglobulin heavy constant epsilon	Homo sapiens	59-62
6675525-1	1983	Results of total and specific IgE levels before and after immunotherapy carried out with calcium-phosphate-adjuvanted house dust and mite allergens for 36 patients are reported here.	calcium phosphate	89-106	immunoglobulin heavy constant epsilon	Homo sapiens	30-33
6188162-1	1983	beta 2-Microglobulin (beta 2m) is expressed on the cell surface after introduction of a beta 2mb (C57BL/6N) genomic clone into thymidine kinase-deficient mouse L cells by cotransformation using the calcium phosphate precipitate method.	calcium phosphate	198-215	beta-2 microglobulin	Mus musculus	0-20
6188162-1	1983	beta 2-Microglobulin (beta 2m) is expressed on the cell surface after introduction of a beta 2mb (C57BL/6N) genomic clone into thymidine kinase-deficient mouse L cells by cotransformation using the calcium phosphate precipitate method.	calcium phosphate	198-215	beta-2 microglobulin	Mus musculus	22-29
7067299-0	1982	Changes in calcium phosphate on bone surfaces and in lining cells after the administration of parathyroid hormone or calcitonin.	calcium phosphate	11-28	parathyroid hormone	Rattus norvegicus	94-113
14582156-1	1982	Recombinant phage particles carrying the thymidine kinase (TK) gene of herpes simplex virus type 1, coprecipitated with calcium phosphate, efficiently transformed mouse Ltk- cells to the TK+ phenotype.	calcium phosphate	120-137	involved in nucleotide metabolism	Human alphaherpesvirus 1	41-57
14582156-1	1982	Recombinant phage particles carrying the thymidine kinase (TK) gene of herpes simplex virus type 1, coprecipitated with calcium phosphate, efficiently transformed mouse Ltk- cells to the TK+ phenotype.	calcium phosphate	120-137	involved in nucleotide metabolism	Human alphaherpesvirus 1	59-61
14582156-1	1982	Recombinant phage particles carrying the thymidine kinase (TK) gene of herpes simplex virus type 1, coprecipitated with calcium phosphate, efficiently transformed mouse Ltk- cells to the TK+ phenotype.	calcium phosphate	120-137	leukocyte tyrosine kinase	Mus musculus	169-172
7067299-0	1982	Changes in calcium phosphate on bone surfaces and in lining cells after the administration of parathyroid hormone or calcitonin.	calcium phosphate	11-28	calcitonin-related polypeptide alpha	Rattus norvegicus	117-127
7067299-3	1982	Amorphous calcium phosphate, which appears as clusters and globules by this "freeze substitution" preparation, appears on the bone surfaces in a short time after the administration of a small dose of calcitonin.	calcium phosphate	10-27	calcitonin-related polypeptide alpha	Rattus norvegicus	200-210
72756-5	1977	Immuno-histological staining for collagen types, and von Kossa staining for calcium phosphate on parallel sections, demonstrated that type I and type II collagen matrices were substrates for calcification.	calcium phosphate	76-93	collagen type II alpha 1 chain	Gallus gallus	134-161
6270097-1	1981	The human delta- and beta-globin genes, contained in a recombinant bacteriophage (lambda H beta G1), were introduced into mouse fibroblasts by cotransformation with a plasmid (chi 1) containing the herpes simplex thymidine kinase gene using the calcium phosphate precipitation technique.	calcium phosphate	245-262	hemoglobin subunit delta	Homo sapiens	10-32
7354083-1	1980	The two major forms of rat liver phenylalanine hydroxylase have been resolved by calcium phosphate chromatography and have been highly purified.	calcium phosphate	81-98	phenylalanine hydroxylase	Rattus norvegicus	33-58
542706-1	1979	Cytoplasmic malate dehydrogenase has been purified 20 -- fold from the supernatant fraction of chicken liver homogenates in 0.25 M sucrose (differential centrifugation at 100,000 x g) through calcium phosphate gel absorption, ammonium sulphate fractionation (45-80% saturation) and Sephadex G-100 chromatography.	calcium phosphate	192-209	malic enzyme 1	Gallus gallus	12-32
6187640-4	1982	Liberating antithrombin III from calciumphosphate is made with care without using any concentrated salt solutions.	calcium phosphate	33-49	serpin family C member 1	Homo sapiens	11-27
6457843-2	1981	Cl2MDP is isolated from biological samples by adsorption onto precipitated calcium phosphate.	calcium phosphate	75-92	endogenous retrovirus group W member 5	Homo sapiens	0-3
6249181-2	1980	Cyclophosphamide (CY) increased whereas the talc embedded in a calcium phosphate gel (TCP) decreased the susceptibility of mice to systemic candidiasis estimated by measuring mean survival time and "renal infectivity" 12 h after challenge.	calcium phosphate	63-80	secretoglobin, family 1B, member 27	Mus musculus	86-89
16660435-1	1978	The photoreducible cytochrome (Cyt) b from Dictyostelium discoideum was purified by differential precipitation with ammonium sulfate and chromatography over Sephadex G-100, diethylaminoethyl-cellulose, and calcium phosphate.	calcium phosphate	206-223	cytb	Dictyostelium discoideum	19-37
857699-7	1977	On the basis of this distinct correlation of EDS frequency with amounts of CaBP known to be present in chick duodenum, it seems that EDS, precipitated calcium phosphate, strongly suggest the sites of CaBP.	calcium phosphate	151-168	calcium-binding protein	Gallus gallus	75-79
18469-2	1977	Thymidylate kinase derived from the blast cells of human chronic myelocytic leukemia was purified 2186-fold to near homogeneity by means of alcohol precipitation, alumina-Cgamma gel fractionation, calcium phosphate gel fraction, ultrafiltration, and affinity column chromatography.	calcium phosphate	197-214	deoxythymidylate kinase	Homo sapiens	0-18
838735-0	1977	Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva.	calcium phosphate	88-105	statherin	Homo sapiens	31-40
857699-7	1977	On the basis of this distinct correlation of EDS frequency with amounts of CaBP known to be present in chick duodenum, it seems that EDS, precipitated calcium phosphate, strongly suggest the sites of CaBP.	calcium phosphate	151-168	calcium-binding protein	Gallus gallus	200-204
838735-1	1977	The complete amino acid sequence of human salivary statherin, a peptide which strongly inhibits precipitation from supersaturated calcium phosphate solutions, and therefore stabilizes supersaturated saliva, has been determined.	calcium phosphate	130-147	statherin	Homo sapiens	51-60
953793-2	1976	It is found that the capacity of elastin coacervates to initiate calcification is a bulk property of the coacervate and not limited to the serum-coacervate interface, that the calcium phosphate deposits act to bind the protein units together and slow the dissolution and spreading of the coacervate as it floats on an airwater interface, and that, within the limits of detectability, there is no involvement of sulfur.	calcium phosphate	176-193	elastin	Homo sapiens	33-40
11877-2	1976	The kinetics of growth of calcium phosphate on synthetic HAP seed crystals has been studied at 37 degrees C and at pH values of 4.5 and 5.0 by the pH-stat controlled addition of base.	calcium phosphate	26-43	reticulon 3	Homo sapiens	57-60
953793-3	1976	As the charged groups of alpha-elastin had been blocked, the initiation of deposition is due to neutral sites in the protein which are tightly bound to the calcium phosphate deposits.	calcium phosphate	156-173	elastin	Homo sapiens	31-38
1254583-3	1976	Rhodopsin was extracted with detergents and purified by chromatographic procedures involving calcium phosphate/celite chromatography followed by affinity chromatograpy on concanavalin A-Sepharose (or in some cases, gel filtration on agarose).	calcium phosphate	93-110	rhodopsin	Bos taurus	0-9
945752-3	1976	5"-Nucleotidase (5"-ribonucleotide phosphohydrolase, EC 3.1.3.5) from the cytosol of chicken liver has been purified 1860-fold with an overall yield of 20% by a combination of precipitation at pH 5.3, (NH4)2SO4 fractionation, calcium phosphate gel adsorption, phosphocellulose chromatography and gel filtration with Sephadex G-200.	calcium phosphate	226-243	5'-nucleotidase ecto	Gallus gallus	0-15
968810-0	1976	Effect of calcium phosphate on thrombin and on its sensitivity to heparin and antithrombin-III.	calcium phosphate	10-27	coagulation factor II, thrombin	Homo sapiens	31-39
968810-0	1976	Effect of calcium phosphate on thrombin and on its sensitivity to heparin and antithrombin-III.	calcium phosphate	10-27	serpin family C member 1	Homo sapiens	78-94
51655-4	1975	Purification by calcium phosphate gel elution and DEAE chromatography effectively separated this enzyme from cytidine deaminase, which deaminates both CdR and ara-C, and from uridine-cytidine kinase, the enzyme which phosphorylates 5-azacytidine.	calcium phosphate	16-33	cytidine deaminase	Homo sapiens	109-127
816379-1	1976	Renin substrate was initially extracted from human plasma by (NH4)2SO4 followed by chromatography on Sephadex G-150, DEAE cellulose, calcium phosphate gel, isoelectric focusing and preparative polyacrylamide gel electrophoresis.	calcium phosphate	133-150	renin	Homo sapiens	0-5
169257-2	1975	Angiotensin-converting enzyme has been solubilized from a particulate fraction of rabbit lung and purified to apparent homogeneity in 11% yield by a procedure including fractionation with DEAE-cellulose and calcium phosphate gel, elution from Sephadex G-200, and lectin affinity chromatography.	calcium phosphate	207-224	angiotensin-converting enzyme	Oryctolagus cuniculus	0-29
4511318-0	1973	Reactions of enamel surfaces and neutral calcium phosphate solutions after combinations of topical APF and SnF 2 .	calcium phosphate	41-58	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	107-112
1225517-5	1975	After further concentration by adsorption to a calcium-phosphate-gel the ISP degrades pure porcine insulin within 20" down to a rest of 9%, but only 7% of pure porcine proinsulin is altered.	calcium phosphate	47-64	insulin	Homo sapiens	99-106
1148898-2	1975	Spheroids were similar to amorphous calcium phosphate shown previously in syn thetic preparations and in bone.	calcium phosphate	36-53	synemin	Homo sapiens	74-77
5496495-0	1970	The effect of imidodiphosphate (P-N-P) on the precipitation and dissolution of calcium phosphate in vitro.	calcium phosphate	79-96	purine nucleoside phosphorylase	Homo sapiens	32-37
4703037-0	1973	The effects of 0.05 to 5.0 mM NaF on calcium phosphate mineral accretion and subsequent acid dissolution at enamel surfaces.	calcium phosphate	37-54	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
33831568-0	2021	PROTEOMIC ANALYSIS IDENTIFIED LBP AND CD14 AS KEY PROTEINS IN BLOOD/BIPHASIC CALCIUM PHOSPHATE MICROPARTICLE INTERACTIONS.	calcium phosphate	77-94	lipopolysaccharide binding protein	Homo sapiens	30-33
5941349-11	1966	A 400-500-fold purification of the ribonuclease inhibitor was achieved by ammonium sulphate fractionation, treatment with calcium phosphate gel and DEAE-cellulose chromatography.	calcium phosphate	122-139	ribonuclease/angiogenin inhibitor	Rattus norvegicus	35-57
14102873-6	1964	A 120-fold purification of the proteinase was obtained from the cell-free culture medium by ammonium sulfate fractionation, calcium phosphate gel treatment, and chromatography on diethylaminoethyl cellulose.	calcium phosphate	124-141	prtP	Lactococcus lactis	31-41
13710679-12	1961	It has been shown that rechromatography of crystalline proteinase precursor and desoxyribonuclease B on calcium phosphate columns resulted in elution principally at the expected stepwise increase in buffer concentration.	calcium phosphate	104-121	endogenous retrovirus group K member 18	Homo sapiens	55-65
13378507-0	1956	Chromatography of insulin on calcium phosphate columns.	calcium phosphate	29-46	insulin	Homo sapiens	18-25
33862571-5	2021	Young"s modulus of the alpha-CD/C9-PVA bone paste was lower than that of commercial calcium phosphate paste.	calcium phosphate	84-101	adrenocortical dysplasia	Mus musculus	23-31
24519219-6	1968	When mitochondria prelabeled with (45)Ca, after extracting their inorganic calcium phosphate, were treated with RNase a liberation of Ca, ribonucleotide, and phosphate was observed.	calcium phosphate	75-92	intracellular ribonuclease LX	Solanum tuberosum	112-117
14072176-1	1963	A macromolecule of protein and chondroitin sulfate (PP-L) inhibits sedimentation of barium-polystyrene sulfonate (BaPSS) and of calcium phosphate at low but not at high values of gravity.	calcium phosphate	128-145	periplakin	Homo sapiens	52-56
33831568-0	2021	PROTEOMIC ANALYSIS IDENTIFIED LBP AND CD14 AS KEY PROTEINS IN BLOOD/BIPHASIC CALCIUM PHOSPHATE MICROPARTICLE INTERACTIONS.	calcium phosphate	77-94	CD14 molecule	Homo sapiens	38-42
33845570-8	2021	To demonstrate the application in studying bone metastasis, we delivered a PC3 prostate cancer-conditioned medium and confirmed that both the differentiation of monocytes into osteoclasts and the osteoclastic resorption of the calcium phosphate coating were significantly enhanced.	calcium phosphate	227-244	chromobox 8	Homo sapiens	75-78
34010434-1	2021	Introduction Elevated serum parathormone (PTH) levels have been observed in acute kidney injury and are related to calcium-phosphate metabolism disturbance, decreased renal production of 1,25 dihydroxyvitamin D3, impaired renal PTH excretion and other renal-independent factors.	calcium phosphate	115-132	parathyroid hormone	Homo sapiens	42-45
33996793-2	2021	Fetuin-A stabilizes calcium phosphate mineral initially as ion clusters to form calciprotein monomers (CPM), and then as larger multimeric consolidations containing amorphous calcium phosphate (primary CPP, CPP 1) or more crystalline phases (secondary CPP, CPP 2).	calcium phosphate	20-37	alpha 2-HS glycoprotein	Homo sapiens	0-8
33996793-2	2021	Fetuin-A stabilizes calcium phosphate mineral initially as ion clusters to form calciprotein monomers (CPM), and then as larger multimeric consolidations containing amorphous calcium phosphate (primary CPP, CPP 1) or more crystalline phases (secondary CPP, CPP 2).	calcium phosphate	175-192	alpha 2-HS glycoprotein	Homo sapiens	0-8
33996793-16	2021	Conclusions: Fetuin-A prevents calcium phosphate precipitation by forming CPM, which transform into CPP.	calcium phosphate	31-48	alpha 2-HS glycoprotein	Homo sapiens	13-21
33998210-0	2021	[Clinical study of calcium phosphate cement loaded with recombinant human bone morphogenetic protein 2 combined with calcium phosphate cement loaded with antibiotic for chronic osteomyelitis with bone defect].	calcium phosphate	19-36	bone morphogenetic protein 2	Homo sapiens	74-102
33998210-1	2021	Objective: To compare the effectiveness of calcium phosphate cement (CPC) loaded with recombinant human bone morphogenetic protein 2 (rhBMP-2) combined with CPC loaded with antibiotic versus CPC loaded with antibiotic alone in one stage for chronic osteomyelitis with bone defect.	calcium phosphate	43-60	bone morphogenetic protein 2	Homo sapiens	104-132
33784444-6	2021	Klotho protein participates in the regulation of several biological activities, including regulation of calcium-phosphate homeostasis and PTH as well as vitamin D metabolism.	calcium phosphate	104-121	klotho	Mus musculus	0-6
33561513-0	2021	Building an Aprismatic Enamel-Like Layer on a Demineralized Enamel Surface by using Carboxymethyl Chitosan and Lysozyme-Encapsulated Amorphous Calcium Phosphate Nanogels.	calcium phosphate	143-160	lysozyme	Homo sapiens	111-119
33561513-1	2021	OBJECTIVES: The purpose of this study was to prepare carboxymethyl chitosan (CMC) and lysozyme nanogels that could encapsulate amorphous calcium phosphate (ACP) for achieving its controlled delivery, thus forming an aprismatic enamel-like layer on the demineralized enamel surface.	calcium phosphate	137-154	lysozyme	Homo sapiens	86-94
33059036-6	2021	When grown in inorganic phosphate-supplemented medium, these cells deposited calcium phosphate minerals, which could be prevented by an N"-terminal peptide of MGP (m3pS) carrying phosphorylated serine residues.	calcium phosphate	77-94	matrix Gla protein	Mus musculus	159-162
33423524-3	2021	The pleiotropic functions of Klotho include, but are not limited to, inhibition of insulin/IGF-1 (insulin-like growth factor 1) and WNT (wingless-related integration site) signaling pathways, suppression of oxidative stress and aldosterone secretion, regulation of calcium-phosphate homeostasis, and modulation of autophagy with inhibition of apoptosis, fibrosis, and cell senescence.	calcium phosphate	265-282	klotho	Mus musculus	29-35
33315697-3	2021	A safety study involving intra-articular injection of bone morphogenetic protein-2 (BMP-2)/calcium phosphate matrix (CPM) or CPM addresses these issues.	calcium phosphate	91-108	carboxypeptidase M	Homo sapiens	117-120
33028781-8	2021	In the blood, calcium-phosphate crystals are adsorbed by serum protein fetuin-A and prevented from growing into large precipitates.	calcium phosphate	14-31	alpha-2-HS-glycoprotein	Mus musculus	71-79
33394515-3	2021	This nanoplatform is constructed by a facile one-step biomineralization method using poly(ethylene glycol)-modified glucose oxidase (GOx) as a template to form biodegradable copper-doped calcium phosphate nanoparticles, followed by the loading of doxorubicin (DOX).	calcium phosphate	187-204	hydroxyacid oxidase 1	Homo sapiens	116-131
33540061-0	2021	Delivery of Toll-Like Receptor 3 Ligand Poly(I:C) to the Liver by Calcium Phosphate Nanoparticles Conjugated with an F4/80 Antibody Exerts an Anti-Hepatitis B Virus Effect in a Mouse Model.	calcium phosphate	66-83	toll like receptor 3	Homo sapiens	12-32
33540061-0	2021	Delivery of Toll-Like Receptor 3 Ligand Poly(I:C) to the Liver by Calcium Phosphate Nanoparticles Conjugated with an F4/80 Antibody Exerts an Anti-Hepatitis B Virus Effect in a Mouse Model.	calcium phosphate	66-83	adhesion G protein-coupled receptor E1	Mus musculus	117-122
33394515-3	2021	This nanoplatform is constructed by a facile one-step biomineralization method using poly(ethylene glycol)-modified glucose oxidase (GOx) as a template to form biodegradable copper-doped calcium phosphate nanoparticles, followed by the loading of doxorubicin (DOX).	calcium phosphate	187-204	hydroxyacid oxidase 1	Homo sapiens	133-136
33484482-6	2021	Histochemical staining revealed abnormal accumulation of calcium phosphate-like deposits and collagen fibrils in Trpm3-mutant lenses and immunoblotting detected increased alphaII-spectrin cleavage products consistent with calpain hyper-activation.	calcium phosphate	57-74	transient receptor potential cation channel, subfamily M, member 3	Mus musculus	113-118
33553148-0	2020	Low Dose BMP2-Doped Calcium Phosphate Graft Promotes Bone Defect Healing in a Large Animal Model.	calcium phosphate	20-37	bone morphogenetic protein 2	Rattus norvegicus	9-13
33028786-1	2021	In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical alveolar bone reconstruction outcome of BMP2-CPC with those of deproteinized bovine bone (DBB).	calcium phosphate	45-62	bone morphogenetic protein 2	Bos taurus	27-31
33028786-1	2021	In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical alveolar bone reconstruction outcome of BMP2-CPC with those of deproteinized bovine bone (DBB).	calcium phosphate	45-62	bone morphogenetic protein 2	Bos taurus	71-75
33028786-1	2021	In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical alveolar bone reconstruction outcome of BMP2-CPC with those of deproteinized bovine bone (DBB).	calcium phosphate	45-62	chymosin	Bos taurus	76-79
33028786-1	2021	In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical alveolar bone reconstruction outcome of BMP2-CPC with those of deproteinized bovine bone (DBB).	calcium phosphate	45-62	bone morphogenetic protein 2	Bos taurus	71-75
33316452-11	2021	The decrease in rate of retention of the mitogenic activity of FGF-2 was prevented by a two-step synthesis method to form a composite layer on a precoating with calcium phosphate (9/12 - 12/12).	calcium phosphate	161-178	fibroblast growth factor 2	Homo sapiens	63-68
33252059-18	2021	A change in the activity of apoptotic factors, osteocalcin, and CD44 is caused by gene induction in response to the diffusion of calcium phosphate compounds from coating to surrounding tissue.	calcium phosphate	129-146	bone gamma-carboxyglutamate protein	Rattus norvegicus	47-58
33252059-18	2021	A change in the activity of apoptotic factors, osteocalcin, and CD44 is caused by gene induction in response to the diffusion of calcium phosphate compounds from coating to surrounding tissue.	calcium phosphate	129-146	CD44 molecule (Indian blood group)	Rattus norvegicus	64-68
32814879-8	2021	Moreover, the therapeutic potential of circRNA-vgll3-modified ADSCs with calcium phosphate cement (CPC) scaffolds was systematically evaluated in a critical-sized defect model in rats.	calcium phosphate	73-90	vestigial-like family member 3	Rattus norvegicus	47-52
33189801-1	2021	OBJECTIVES: This study aims to investigate the long-term demineralization-inhibition capability of a rechargeable adhesive with nanoparticles of amorphous calcium phosphate (NACP) on dentin in a biofilm-challenged environment.	calcium phosphate	155-172	synuclein alpha	Homo sapiens	174-178
33706952-5	2021	The FGF23-Klotho endocrine system, when disrupted, results in hyperphosphatemia and ectopic precipitation of calcium phosphate in mice and humans.	calcium phosphate	109-126	fibroblast growth factor 23	Mus musculus	4-9
32193654-7	2021	Sa1 and Pa2 were significantly correlated to RP, anchored stones (Sa) to papillary erosions and calcium phosphate stones to intraductal crystallization.	calcium phosphate	96-113	stromal antigen 1	Homo sapiens	0-3
33792869-5	2021	This chapter focuses on the silencing of two different nuclear ncRNAs (ANRIL and SATIII RNAs) in mammalian cells using antisense LNA GapmeRs with two different transfection methods: calcium phosphate-mediated transfection and LipofectamineTM 2000.	calcium phosphate	182-199	CDKN2B antisense RNA 1	Homo sapiens	71-76
33706952-5	2021	The FGF23-Klotho endocrine system, when disrupted, results in hyperphosphatemia and ectopic precipitation of calcium phosphate in mice and humans.	calcium phosphate	109-126	klotho	Mus musculus	10-16
33361742-4	2020	MATERIAL AND METHODS This study aimed to compare Roche second- and third-generation PTH assays by establishing a quantitative relationship between the results of assays in patients with CKD and assessing degree of their correlation with kidney function and calcium-phosphate and bone metabolism parameters.	calcium phosphate	257-274	parathyroid hormone	Homo sapiens	84-87
33361742-7	2020	PTH concentrations determined with both assays were almost to the same extent correlated with calcium-phosphate and bone metabolism parameters, and renal function indices.	calcium phosphate	94-111	parathyroid hormone	Homo sapiens	0-3
33361742-10	2020	CONCLUSIONS Correcting for the established quantitative differences, the second-and third-generation PTH tests can be used interchangeably, given the almost identical pathophysiological correlations of their results with calcium-phosphate and bone metabolism parameters.	calcium phosphate	221-238	parathyroid hormone	Homo sapiens	101-104
33297306-0	2020	Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide.	calcium phosphate	61-78	RAS like proto-oncogene A	Homo sapiens	109-113
32994008-13	2020	The biomineralization test conducted by simulated body fluid (SBF) incubation showed enhanced calcium-phosphate crystal deposition on the PCL/PPy scaffolds.	calcium phosphate	94-111	polycystic kidney disease 2-like 1	Mus musculus	138-141
32956996-0	2020	Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy.	calcium phosphate	75-92	cyclin B1	Homo sapiens	26-35
33266215-1	2020	Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is one of the most promising candidates of the calcium phosphate family, suitable for bone tissue regeneration due to its structural similarities with human hard tissues.	calcium phosphate	85-102	carbonic anhydrase 10	Homo sapiens	21-36
33036465-8	2020	The character of the crystalline structure is not only governed by the temperature itself but relies on the condition such as either post-deposition treatment, where an amorphous calcium phosphate undergoes crystallization or instantaneous crystalline coating growth during deposition on the hot substrate.	calcium phosphate	179-196	alcohol dehydrogenase iron containing 1	Homo sapiens	292-295
33023124-0	2020	Costimulatory Effect of Rough Calcium Phosphate Coating and Blood Mononuclear Cells on Adipose-Derived Mesenchymal Stem Cells In Vitro as a Model of In Vivo Tissue Repair.	calcium phosphate	30-47	WD and tetratricopeptide repeats 1	Mus musculus	87-94
32710882-0	2020	Lipid composition modulates ATP hydrolysis and calcium phosphate mineral propagation by TNAP-harboring proteoliposomes.	calcium phosphate	47-64	TNAP	Homo sapiens	88-92
32955073-4	2020	And then, the entrapped ALP within the SF-NY gel network retained its catalytic activity, released phosphate ions from glycerophosphate, and catalysed the formation of calcium phosphate minerals within the porous gel.	calcium phosphate	168-185	PDZ and LIM domain 3	Rattus norvegicus	24-27
32386861-1	2020	BACKGROUND & AIMS: Abnormalities of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) secretion may cause calcium-phosphate (Ca-P) metabolism disorders in nephrolithiasis.	calcium phosphate	122-139	parathyroid hormone	Homo sapiens	57-60
32386861-1	2020	BACKGROUND & AIMS: Abnormalities of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) secretion may cause calcium-phosphate (Ca-P) metabolism disorders in nephrolithiasis.	calcium phosphate	122-139	fibroblast growth factor 23	Homo sapiens	66-93
32386861-1	2020	BACKGROUND & AIMS: Abnormalities of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) secretion may cause calcium-phosphate (Ca-P) metabolism disorders in nephrolithiasis.	calcium phosphate	122-139	fibroblast growth factor 23	Homo sapiens	95-100
32386861-1	2020	BACKGROUND & AIMS: Abnormalities of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) secretion may cause calcium-phosphate (Ca-P) metabolism disorders in nephrolithiasis.	calcium phosphate	141-145	parathyroid hormone	Homo sapiens	57-60
32386861-1	2020	BACKGROUND & AIMS: Abnormalities of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) secretion may cause calcium-phosphate (Ca-P) metabolism disorders in nephrolithiasis.	calcium phosphate	141-145	fibroblast growth factor 23	Homo sapiens	66-93
32386861-1	2020	BACKGROUND & AIMS: Abnormalities of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) secretion may cause calcium-phosphate (Ca-P) metabolism disorders in nephrolithiasis.	calcium phosphate	141-145	fibroblast growth factor 23	Homo sapiens	95-100
32806283-9	2020	In addition, the in vitro SBF biomineralization and ARS test showed improved calcium-phosphate deposition on the PZM composite scaffold.	calcium phosphate	77-94	secreted Ly6/Plaur domain containing 1	Mus musculus	52-55
33109053-8	2021	Calcium phosphate was used to transfect the CRMP2 and spastin constructs and their control into the neurons.	calcium phosphate	0-17	dihydropyrimidinase like 2	Homo sapiens	44-49
33109053-8	2021	Calcium phosphate was used to transfect the CRMP2 and spastin constructs and their control into the neurons.	calcium phosphate	0-17	spastin	Homo sapiens	54-61
32992463-0	2020	Calcium Phosphate Coating Prepared by Microarc Oxidation Affects hTERT Expression, Molecular Presentation, and Cytokine Secretion in Tumor-Derived Jurkat T Cells.	calcium phosphate	0-17	telomerase reverse transcriptase	Homo sapiens	65-70
32992463-6	2020	Hyperactivation-dependent death of CD4+ cells triggered by the surface roughness of the CaP coating was proposed.	calcium phosphate	88-91	CD4 molecule	Homo sapiens	35-38
32973201-0	2020	Osteopontin regulates biomimetic calcium phosphate crystallization from disordered mineral layers covering apatite crystallites.	calcium phosphate	33-50	secreted phosphoprotein 1	Homo sapiens	0-11
32892621-1	2020	Thermally and hydrolytically unstable di-tert-butyl phosphate (dtbp-H) has been used as synthon to prepare discrete and polymeric calcium phosphates that are convenient single-source precursors for a range of calcium phosphate ceramic biomaterials.	calcium phosphate	130-147	amyloid beta precursor protein	Homo sapiens	5-6
32994008-15	2020	Furthermore, ALP and ARS staining assays showed significant enhancement of the calcium-phosphate deposition on the PCL/PPy scaffolds after ES treatment.	calcium phosphate	79-96	alopecia, recessive	Mus musculus	13-16
32994008-15	2020	Furthermore, ALP and ARS staining assays showed significant enhancement of the calcium-phosphate deposition on the PCL/PPy scaffolds after ES treatment.	calcium phosphate	79-96	secreted Ly6/Plaur domain containing 1	Mus musculus	21-24
32994008-15	2020	Furthermore, ALP and ARS staining assays showed significant enhancement of the calcium-phosphate deposition on the PCL/PPy scaffolds after ES treatment.	calcium phosphate	79-96	polycystic kidney disease 2-like 1	Mus musculus	115-118
32307113-1	2020	BACKGROUND AND AIMS: Calciprotein particles (CPPs), nano-aggregates containing fetuin-A-bound calcium-phosphate, are associated with aortic stiffness and coronary calcification in maintenance hemodialysis patients.	calcium phosphate	94-111	alpha 2-HS glycoprotein	Homo sapiens	79-87
32507875-5	2020	MATERIALS AND METHODS: We used the calcium phosphate protocol to transfect vectors contained miR-155 or miR-off 155 and alone eGFP into Cumulus Oophorus Complex (COCs) of B6D2F1 female mice for in vitro maturation.	calcium phosphate	35-52	microRNA 155	Mus musculus	93-100
32527499-2	2020	Dimethylaminohexadecyl methacrylate (DMAHDM) and amorphous calcium phosphate nanoparticles (NACP) impart anti-caries effect by reducing the bacterial growth and releasing high concentrations of calcium and phosphate ions, respectively.	calcium phosphate	59-76	synuclein alpha	Homo sapiens	92-96
33185993-15	2020	This protein affects adipogenesis, metabolism of glucose and lipids as well as calcium-phosphate system by influence on the activity of fibroblast growth factors (FGF19, FGF23, FGF21).	calcium phosphate	79-96	fibroblast growth factor 19	Homo sapiens	163-168
33185993-15	2020	This protein affects adipogenesis, metabolism of glucose and lipids as well as calcium-phosphate system by influence on the activity of fibroblast growth factors (FGF19, FGF23, FGF21).	calcium phosphate	79-96	fibroblast growth factor 23	Homo sapiens	170-175
33185993-15	2020	This protein affects adipogenesis, metabolism of glucose and lipids as well as calcium-phosphate system by influence on the activity of fibroblast growth factors (FGF19, FGF23, FGF21).	calcium phosphate	79-96	fibroblast growth factor 21	Homo sapiens	177-182
33841862-12	2021	In stepwise Cox regression modelled analysis, sclerostin levels were associated with the primary outcome, independently of PTH, calcium-phosphate product, serum albumin, C-reactive protein and PWV levels (HR = 2.921, 95% CI 1.401-6.090; P = 0.004).	calcium phosphate	128-145	sclerostin	Homo sapiens	46-56
33987477-0	2020	Calcium Phosphate Cement Causes Nucleus Pulposus Cell Degeneration through the ERK Signaling Pathway.	calcium phosphate	0-17	mitogen-activated protein kinase 1	Homo sapiens	79-82
32278386-4	2020	The fluorescently-functionalized aptamer was demonstrated to specifically label HAP in a surface binding experiment and suggests the usefulness of this selected aptamer in biomedical or biotechnology fields where the labeling of specific calcium phosphate materials is required.	calcium phosphate	238-255	reticulon 3	Homo sapiens	80-83
32360313-1	2020	OBJECTIVE: Nanoparticles of amorphous calcium phosphate (NACP) have shown beneficial effects of a robust release of calcium and phosphate ions at low pH.	calcium phosphate	38-55	synuclein alpha	Homo sapiens	57-61
32360313-15	2020	We explored the role of amorphous calcium phosphate (NACP) in a newly-developed antibacterial and rechargeable dental sealant formulation as a preventive approach.	calcium phosphate	34-51	synuclein alpha	Homo sapiens	53-57
32548104-0	2020	BMP2-Functionalized Biomimetic Calcium Phosphate Graft Promotes Alveolar Defect Healing During Orthodontic Tooth Movement in Beagle Dogs.	calcium phosphate	31-48	bone morphogenetic protein 2	Canis lupus familiaris	0-4
32548104-2	2020	BMP2-functionalized biomimetic calcium phosphate (BioCaP) graft had shown excellent bone defect healing potential in many preclinical studies.	calcium phosphate	31-48	bone morphogenetic protein 2	Canis lupus familiaris	0-4
32456086-5	2020	PKAN glutamatergic neurons, analyzed by electron microscopy, exhibited electron dense aggregates in mitochondria that were identified as granules containing calcium phosphate.	calcium phosphate	157-174	pantothenate kinase 2	Homo sapiens	0-4
32775307-9	2020	The mean admission calcium-phosphate product was 34.4 +- 11.3 mg2/dL2.	calcium phosphate	19-36	l(1)L2	Drosophila melanogaster	66-69
32190922-1	2020	Dentin matrix protein 1 (DMP1) is an acidic, extracellular matrix protein essential for biomineralization of calcium phosphate, in bone and dentin.	calcium phosphate	109-126	dentin matrix acidic phosphoprotein 1	Homo sapiens	0-23
32190922-1	2020	Dentin matrix protein 1 (DMP1) is an acidic, extracellular matrix protein essential for biomineralization of calcium phosphate, in bone and dentin.	calcium phosphate	109-126	dentin matrix acidic phosphoprotein 1	Homo sapiens	25-29
32370039-8	2020	VEGFR-2 activity increased in the + Sr group from days 0-15 but decreased and showed significantly less activity than the beta-TCP and non-scaffold groups from days 40-60.	calcium phosphate	122-130	kinase insert domain protein receptor	Mus musculus	0-7
31925903-0	2020	The Implication of the Notch Signaling Pathway in Biphasic Calcium Phosphate Ceramic-induced Ectopic Bone Formation: A Preliminary Experiment.	calcium phosphate	59-76	notch receptor 1	Canis lupus familiaris	23-28
32775307-11	2020	In adjusted analysis, admission calcium-phosphate product of >=45 mg2/dL2 was significantly associated with increased 1-year mortality with hazard ratio of 1.41 (95% 95% confidence interval 1.25-1.67), whereas lower admission calcium-phosphate product was not significantly associated with 1-year mortality.	calcium phosphate	32-49	l(1)L2	Drosophila melanogaster	70-73
32775307-11	2020	In adjusted analysis, admission calcium-phosphate product of >=45 mg2/dL2 was significantly associated with increased 1-year mortality with hazard ratio of 1.41 (95% 95% confidence interval 1.25-1.67), whereas lower admission calcium-phosphate product was not significantly associated with 1-year mortality.	calcium phosphate	226-243	l(1)L2	Drosophila melanogaster	70-73
32001068-4	2020	Calciprotein particles are nanoparticles of calcium-phosphate precipitates bound to serum protein fetuin-A and are generated spontaneously in solution containing calcium, phosphate, and fetuin-A to be dispersed as colloids.	calcium phosphate	44-61	alpha-2-HS-glycoprotein	Mus musculus	98-106
32249825-8	2020	In multivariate logistic regression models, higher LRG1 tertile was significantly associated with PAOD (odds ratio = 3.49) and CVD (odds ratio = 1.65), but not with coronary artery disease, history of myocardial infarction, or stroke after adjusting for gender, diabetes, hemoglobin, albumin, calcium-phosphate product, and level of hsCRP.	calcium phosphate	293-310	leucine rich alpha-2-glycoprotein 1	Homo sapiens	51-55
32001068-6	2020	When transition of calcium-phosphate precipitates from the amorphous phase to the crystalline phase was blocked by bisphosphonate, the calciprotein particle size was reduced and FGF23 expression was augmented, suggesting that small calciprotein particles containing amorphous calcium-phosphate precipitates function as a more potent FGF23 inducer than larger calciprotein particles containing crystalline calcium-phosphate precipitates.	calcium phosphate	19-36	fibroblast growth factor 23	Mus musculus	178-183
32001068-6	2020	When transition of calcium-phosphate precipitates from the amorphous phase to the crystalline phase was blocked by bisphosphonate, the calciprotein particle size was reduced and FGF23 expression was augmented, suggesting that small calciprotein particles containing amorphous calcium-phosphate precipitates function as a more potent FGF23 inducer than larger calciprotein particles containing crystalline calcium-phosphate precipitates.	calcium phosphate	19-36	fibroblast growth factor 23	Mus musculus	333-338
31982590-0	2020	Reduction of inflammation in a chronic periodontitis model in rats by TNF-alpha gene silencing with a topically applied siRNA-loaded calcium phosphate paste.	calcium phosphate	133-150	tumor necrosis factor	Rattus norvegicus	70-79
31982590-1	2020	We developed a calcium phosphate-based paste containing siRNA against TNF-alpha and investigated its anti-inflammatory and bone-healing effects in vitro and in vivo in a rat periodontitis model.	calcium phosphate	15-32	tumor necrosis factor	Rattus norvegicus	70-79
31982590-5	2020	In vivo, ALP mRNA was up-regulated, TNF-alpha mRNA was down-regulated, and the amount of released TNF-alpha was significantly reduced after topical application of the calcium phosphate-based paste containing siRNA-loaded nanoparticles.	calcium phosphate	167-184	tumor necrosis factor	Mus musculus	36-45
31982590-5	2020	In vivo, ALP mRNA was up-regulated, TNF-alpha mRNA was down-regulated, and the amount of released TNF-alpha was significantly reduced after topical application of the calcium phosphate-based paste containing siRNA-loaded nanoparticles.	calcium phosphate	167-184	tumor necrosis factor	Mus musculus	98-107
31982590-8	2020	These results demonstrate that local application of a paste consisting of siRNA-loaded calcium phosphate nanoparticles successfully induces TNF-alpha silencing in vitro and in vivo and removes the suppression of ALP activity stimulated by inflammation.	calcium phosphate	87-104	tumor necrosis factor	Mus musculus	140-149
32121590-0	2020	Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System.	calcium phosphate	87-104	CD8a molecule	Homo sapiens	69-72
32036670-0	2020	Phosphorylated/Nonphosphorylated Motif in Amelotin Turns off/on the Acidic Amorphous Calcium Phosphate-to-Apatite Phase Transformation.	calcium phosphate	85-102	amelotin	Homo sapiens	42-50
32036670-1	2020	Amelotin (AMTN) as a matrix protein exerts a direct effect on biomineralization by modulating apatite (HAP) formation during the dental enamel maturation stage through the specific interaction of a potentially phosphorylated Ser-Ser-Glu-Glu-Leu (SSEEL) peptide fragment with calcium phosphate (Ca-P) surfaces.	calcium phosphate	275-292	amelotin	Homo sapiens	0-8
32036670-1	2020	Amelotin (AMTN) as a matrix protein exerts a direct effect on biomineralization by modulating apatite (HAP) formation during the dental enamel maturation stage through the specific interaction of a potentially phosphorylated Ser-Ser-Glu-Glu-Leu (SSEEL) peptide fragment with calcium phosphate (Ca-P) surfaces.	calcium phosphate	275-292	amelotin	Homo sapiens	10-14
32036670-1	2020	Amelotin (AMTN) as a matrix protein exerts a direct effect on biomineralization by modulating apatite (HAP) formation during the dental enamel maturation stage through the specific interaction of a potentially phosphorylated Ser-Ser-Glu-Glu-Leu (SSEEL) peptide fragment with calcium phosphate (Ca-P) surfaces.	calcium phosphate	294-298	amelotin	Homo sapiens	0-8
32036670-1	2020	Amelotin (AMTN) as a matrix protein exerts a direct effect on biomineralization by modulating apatite (HAP) formation during the dental enamel maturation stage through the specific interaction of a potentially phosphorylated Ser-Ser-Glu-Glu-Leu (SSEEL) peptide fragment with calcium phosphate (Ca-P) surfaces.	calcium phosphate	294-298	amelotin	Homo sapiens	10-14
31730250-1	2020	OBJECTIVE: We hypothesized that a biomimetic calcium phosphate (CaP) coating which incorporates morphogenetic protein 2 (BMP-2) on the deproteinized bovine bone (DBB) blocks could be used to enhance the vertical alveolar ridge augmentation for the one-stage onlay surgery with simultaneous implants insertion.	calcium phosphate	45-62	bone morphogenetic protein 2	Bos taurus	121-126
31730250-1	2020	OBJECTIVE: We hypothesized that a biomimetic calcium phosphate (CaP) coating which incorporates morphogenetic protein 2 (BMP-2) on the deproteinized bovine bone (DBB) blocks could be used to enhance the vertical alveolar ridge augmentation for the one-stage onlay surgery with simultaneous implants insertion.	calcium phosphate	64-67	bone morphogenetic protein 2	Bos taurus	121-126
31963457-2	2020	A calcium phosphate-based glass particulate (PGP) filler of the formulation 50P2O5-40CaO-10TiO2 mol.%, was incorporated into biodegradable poly(d,l-lactic acid) (PDLLA) at 5, 10, 20, and 30 vol.%.	calcium phosphate	2-19	phosphoglycolate phosphatase	Homo sapiens	45-48
32106409-1	2020	An analytical method to measure solubilized orthophosphate ions (HPO42- and PO43- ) from the water-insoluble food additives calcium phosphate dibasic (DCP) and calcium phosphate tribasic (TCP) in processed foods was optimized by comparing ion chromatography (IC) coupled with DS6 conductivity detector (Cond.)	calcium phosphate	160-186	serine peptidase inhibitor Kazal type 1	Homo sapiens	188-191
31919099-4	2020	Phosphorylation of the sole AMELX phosphorylation site (Ser-16) in vitro greatly enhances its capacity to stabilize amorphous calcium phosphate (ACP), the first mineral phase formed in developing enamel, and prevents apatitic crystal formation.	calcium phosphate	126-143	amelogenin X-linked	Homo sapiens	28-33
31979095-5	2020	Topical application of fermenting C. acnes, butyric acid or BA-NH-NH-BA onto mouse skin effectively ameliorated CaP-induced skin itching, interleukin (IL)-6 up-regulation in keratinocytes, and extracellular signal-regulated kinase (ERK) 1/2 activation in dorsal root ganglia (DRG).	calcium phosphate	112-115	mitogen-activated protein kinase 3	Mus musculus	193-240
31979095-6	2020	Activation of ERK 1/2 by CaP was markedly reduced in IL-6 knockout mice.	calcium phosphate	25-28	mitogen-activated protein kinase 3	Mus musculus	14-21
31979095-6	2020	Activation of ERK 1/2 by CaP was markedly reduced in IL-6 knockout mice.	calcium phosphate	25-28	interleukin 6	Mus musculus	53-57
31979095-8	2020	Our results identify a role for the skin fermenting C. acnes in ameliorating CaP-induced activation of IL-6/p-ERK signaling and resulting skin inflammation.	calcium phosphate	77-80	interleukin 6	Mus musculus	103-107
31942755-1	2020	BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is associated with atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization.	calcium phosphate	151-168	fibroblast growth factor 23	Homo sapiens	24-51
30009696-3	2020	The modulation of tissue calcification by MGP is potentially regulated in several ways including direct inhibition of calcium-phosphate precipitation, the formation of matrix vesicles (MVs), the formation of apoptotic bodies (ABs), and trans-differentiation of VSMCs.	calcium phosphate	118-135	matrix Gla protein	Homo sapiens	42-45
31942755-1	2020	BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is associated with atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization.	calcium phosphate	151-168	fibroblast growth factor 23	Homo sapiens	53-58
31890557-2	2020	PAM is classically characterized by calcium phosphate deposition within alveolar airspaces due to SLC34A2 (solute carrier family 34 member 2) gene mutation located on chromosome 4p15.2.	calcium phosphate	36-53	solute carrier family 34 member 2	Homo sapiens	98-105
31837358-1	2020	OBJECTIVES: The objective of this study was to investigate enamel remineralization using salivary statherin protein-inspired poly(amidoamine) dendrimer (SN15-PAMAM) and adhesive containing nanoparticles of amorphous calcium phosphate (NACP) in a cyclic artificial saliva/demineralizing solution for the first time.	calcium phosphate	216-233	statherin	Homo sapiens	98-107
31903104-0	2020	Liver-targeted delivery of TSG-6 by calcium phosphate nanoparticles for the management of liver fibrosis.	calcium phosphate	36-53	TNF alpha induced protein 6	Homo sapiens	27-32
31833366-2	2019	Herein, GOx is mineralized with manganese-doped calcium phosphate (MnCaP) to form spherical nanoparticles (GOx-MnCaP NPs) by an in situ biomimetic mineralization method, followed by the loading of doxorubicin (DOX) to construct a biodegradable, biocompatible, and tumor acidity-responsive nanotheranostics for magnetic resonance imaging (MRI) and cascade reaction-enhanced cooperative cancer treatment.	calcium phosphate	48-65	hydroxyacid oxidase 1, liver	Mus musculus	8-11
31835689-4	2019	Calcium poly(ethylene phosphate)s (PEP-Ca) appear to be potentially suitable candidates primarily because of PEP"s biodegradability.	calcium phosphate	0-33	leucine aminopeptidase 3	Homo sapiens	109-114
31890557-2	2020	PAM is classically characterized by calcium phosphate deposition within alveolar airspaces due to SLC34A2 (solute carrier family 34 member 2) gene mutation located on chromosome 4p15.2.	calcium phosphate	36-53	solute carrier family 34 member 2	Homo sapiens	107-140
31244014-1	2019	Calcium phosphate minerals deposit on the elastin-rich medial layers of arteries in the majority of seniors, diabetic, and chronic kidney disease patients, causing severe cardiovascular complications.	calcium phosphate	0-17	elastin	Homo sapiens	42-49
31518453-1	2019	AIM: To evaluate the effect of bone morphogenetic protein 2 (BMP-2) incorporated biomimetic calcium phosphate (BMP-2/BioCaP) in conjunction with barrier membrane on periodontal regeneration in chronic periodontitis experimental model.	calcium phosphate	92-109	bone morphogenetic protein 2	Canis lupus familiaris	111-116
31729882-1	2019	Deposition of calcium phosphate minerals on the elastin-rich medial layers of arteries can cause severe cardiovascular complications.	calcium phosphate	14-31	elastin	Homo sapiens	48-55
31365830-0	2019	The IL-6/p-BTK/p-ERK signaling mediates the calcium phosphate-induced pruritus.	calcium phosphate	44-61	interleukin 6	Mus musculus	4-8
31365830-0	2019	The IL-6/p-BTK/p-ERK signaling mediates the calcium phosphate-induced pruritus.	calcium phosphate	44-61	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	11-14
31365830-0	2019	The IL-6/p-BTK/p-ERK signaling mediates the calcium phosphate-induced pruritus.	calcium phosphate	44-61	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	15-20
31500064-0	2019	Iron oxide nanoparticle-calcium phosphate cement enhanced the osteogenic activities of stem cells through WNT/beta-catenin signaling.	calcium phosphate	24-41	catenin beta 1	Homo sapiens	110-122
31476321-2	2019	The aim of this study was to investigate the remineralization of demineralized human dentin in a dental biofilm environment via an adhesive containing nanoparticles of amorphous calcium phosphate (NACP).	calcium phosphate	178-195	synuclein alpha	Homo sapiens	197-201
31569763-3	2019	In contrast to soluble Env trimers, Env containing CaP nanoparticles induced activation of naive Env-specific B-cells in vitro.	calcium phosphate	51-54	endogenous retrovirus group K member 20	Homo sapiens	36-39
31569763-3	2019	In contrast to soluble Env trimers, Env containing CaP nanoparticles induced activation of naive Env-specific B-cells in vitro.	calcium phosphate	51-54	endogenous retrovirus group K member 20	Homo sapiens	36-39
31569763-4	2019	Mice previously vaccinated against Tetanus raised stronger humoral immune responses against Env after immunization with Env-CaP-p30 than mice not vaccinated against Tetanus.	calcium phosphate	124-127	melanoma antigen	Mus musculus	92-95
31569763-4	2019	Mice previously vaccinated against Tetanus raised stronger humoral immune responses against Env after immunization with Env-CaP-p30 than mice not vaccinated against Tetanus.	calcium phosphate	124-127	melanoma antigen	Mus musculus	120-123
31569763-4	2019	Mice previously vaccinated against Tetanus raised stronger humoral immune responses against Env after immunization with Env-CaP-p30 than mice not vaccinated against Tetanus.	calcium phosphate	124-127	high mobility group box 1	Mus musculus	128-131
31569763-6	2019	Thus, CaP nanoparticles functionalized with stabilized HIV-1 Env trimers and heterologous T-helper epitopes are able to recruit heterologous T-helper cells induced by a licensed vaccine and improve anti-Env antibody responses by intrastructural help.	calcium phosphate	6-9	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	61-64
31569763-6	2019	Thus, CaP nanoparticles functionalized with stabilized HIV-1 Env trimers and heterologous T-helper epitopes are able to recruit heterologous T-helper cells induced by a licensed vaccine and improve anti-Env antibody responses by intrastructural help.	calcium phosphate	6-9	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	203-206
33448818-3	2019	Effects of two HAP-interacting proteins, osteocalcin (OCN) and osteopontin (OPN), on HAP formation was investigated via in vitro biomineralization experiments, and their outcomes on the crystal structure of calcium phosphate (CaP) was revealed.	calcium phosphate	207-224	bone gamma-carboxyglutamate protein	Homo sapiens	41-52
33448818-3	2019	Effects of two HAP-interacting proteins, osteocalcin (OCN) and osteopontin (OPN), on HAP formation was investigated via in vitro biomineralization experiments, and their outcomes on the crystal structure of calcium phosphate (CaP) was revealed.	calcium phosphate	207-224	secreted phosphoprotein 1	Homo sapiens	63-74
33448818-3	2019	Effects of two HAP-interacting proteins, osteocalcin (OCN) and osteopontin (OPN), on HAP formation was investigated via in vitro biomineralization experiments, and their outcomes on the crystal structure of calcium phosphate (CaP) was revealed.	calcium phosphate	207-224	secreted phosphoprotein 1	Homo sapiens	76-79
31484306-0	2019	In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement.	calcium phosphate	129-146	growth differentiation factor 5	Homo sapiens	59-63
31359759-5	2019	The aim of this work was to synergize the action of Asc with lipid-coated calcium phosphate (CaP) hybrid nanocarrier that can concurrently load polar Fe3+ and nonpolar RSL3, a ferroptosis inducer with the mechanism of inhibiting lipid peroxide repair enzyme (GPX4).	calcium phosphate	74-91	glutathione peroxidase 4	Mus musculus	259-263
31359759-5	2019	The aim of this work was to synergize the action of Asc with lipid-coated calcium phosphate (CaP) hybrid nanocarrier that can concurrently load polar Fe3+ and nonpolar RSL3, a ferroptosis inducer with the mechanism of inhibiting lipid peroxide repair enzyme (GPX4).	calcium phosphate	93-96	glutathione peroxidase 4	Mus musculus	259-263
31038850-9	2019	When implanted, we observed a significant difference between the bone forming capacity of cells expanded in FBS and HPL, with HPL supplementation resulting in almost three times more mineralized tissue within calcium phosphate scaffolds.	calcium phosphate	209-226	galectin 1	Homo sapiens	126-129
31701811-4	2019	For instance, we have shown in rats that the application of calcium phosphate cement (CPC)/propylene glycol alginate (PGA) with bone morphogenetic protein (BMP)-2 or fibroblast growth factor (FGF)-2 resulted in the regeneration of periodontal defects.	calcium phosphate	60-77	bone morphogenetic protein 2	Rattus norvegicus	128-162
31701811-4	2019	For instance, we have shown in rats that the application of calcium phosphate cement (CPC)/propylene glycol alginate (PGA) with bone morphogenetic protein (BMP)-2 or fibroblast growth factor (FGF)-2 resulted in the regeneration of periodontal defects.	calcium phosphate	60-77	fibroblast growth factor 2	Rattus norvegicus	166-198
31731607-1	2019	Calcium phosphate bions (CPBs) are formed under blood supersaturation with calcium and phosphate owing to the mineral chaperone fetuin-A and representing mineralo-organic particles consisting of bioapatite and multiple serum proteins.	calcium phosphate	0-17	alpha-2-HS-glycoprotein	Rattus norvegicus	128-136
30537427-0	2019	Association of klotho gene polymorphism and the regulation of calcium-phosphate metabolism disorders in patients with end-stage renal disease.	calcium phosphate	62-79	klotho	Homo sapiens	15-21
31569763-0	2019	Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help.	calcium phosphate	0-17	endogenous retrovirus group K member 20	Homo sapiens	85-88
31546863-5	2019	Ovotransferrin inhibited osteoclasts differentiation and the calcium-phosphate resorptive ability via the suppression of RANKL-induced nuclear factor kappa-light chain-enhancer of activated B cells (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	calcium phosphate	61-78	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	121-126
31484306-0	2019	In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement.	calcium phosphate	129-146	CD80 molecule	Homo sapiens	65-69
31484306-0	2019	In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement.	calcium phosphate	129-146	bone morphogenetic protein 2	Homo sapiens	75-80
31165423-7	2019	Calcium phosphate content was associated directly with eGFR, inversely with age, and was higher among females.	calcium phosphate	0-17	epidermal growth factor receptor	Homo sapiens	55-59
31417410-3	2019	The phosphorylated form of AMELX stabilizes amorphous calcium phosphate, while crystalline hydroxyapatite forms in the presence of the unphosphorylated protein.	calcium phosphate	54-71	amelogenin	Sus scrofa	27-32
31340468-0	2019	Adsorption of Serum Albumin onto Octacalcium Phosphate in Supersaturated Solutions Regarding Calcium Phosphate Phases.	calcium phosphate	93-110	albumin	Homo sapiens	14-27
31069351-3	2019	This study reports a facile method of retaining full enzymatic activity by immobilizing glucose oxidase (GOx) into core-shell nanoparticles with polydopamine (PDA) sandwiched between a gold nanoparticle (Au NP) core and a calcium phosphate (CaP) shell (Au@PDA@CaP).	calcium phosphate	222-239	hydroxyacid oxidase 1	Homo sapiens	88-103
31017011-2	2019	Urine pH is also of particular interest in stone formers, since it determines the presence of either calcium phosphate or uric acid content in stones.	calcium phosphate	101-118	phenylalanine hydroxylase	Homo sapiens	6-8
31048198-0	2019	The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics.	calcium phosphate	44-61	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	12-17
31048198-0	2019	The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics.	calcium phosphate	44-61	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	18-22
31263178-5	2019	In uremic rats, CNP administration significantly alleviated renal dysfunction, calcium phosphate metabolic disorders, hypovitaminosis D, secondary hyperparathyroidism, the decrease in bone turnover markers and retarded bone pathological progression.	calcium phosphate	79-96	natriuretic peptide C	Rattus norvegicus	16-19
31203904-7	2019	In addition, calcium phosphate nanocrystals that contain fetuin-A are pro-inflammatory to macrophages and promote vascular smooth muscle cell mineralization, potentiating a vicious cycle of inflammation and calcification.	calcium phosphate	13-30	alpha-2-HS-glycoprotein	Mus musculus	57-65
31069351-3	2019	This study reports a facile method of retaining full enzymatic activity by immobilizing glucose oxidase (GOx) into core-shell nanoparticles with polydopamine (PDA) sandwiched between a gold nanoparticle (Au NP) core and a calcium phosphate (CaP) shell (Au@PDA@CaP).	calcium phosphate	222-239	hydroxyacid oxidase 1	Homo sapiens	105-108
30835955-3	2019	Previously, a phage display derived MSC-specific peptide (DPIYALSWSGMA, DPI) was combined with a mineral binding sequence (VTKHLNQISQSY, VTK) to increase the magnitude and specificity of MSC attachment to calcium-phosphate biomaterials in 2D.	calcium phosphate	205-222	musculin	Homo sapiens	36-39
31068570-3	2019	This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).	calcium phosphate	146-163	synuclein alpha	Homo sapiens	165-169
31218132-10	2019	VDR FokI SNP is closely related to renal function, calcium-phosphate metabolism, and related pathological damage in IgAN patients.	calcium phosphate	51-68	vitamin D receptor	Homo sapiens	0-3
31218132-10	2019	VDR FokI SNP is closely related to renal function, calcium-phosphate metabolism, and related pathological damage in IgAN patients.	calcium phosphate	51-68	IGAN1	Homo sapiens	116-120
30835955-3	2019	Previously, a phage display derived MSC-specific peptide (DPIYALSWSGMA, DPI) was combined with a mineral binding sequence (VTKHLNQISQSY, VTK) to increase the magnitude and specificity of MSC attachment to calcium-phosphate biomaterials in 2D.	calcium phosphate	205-222	musculin	Homo sapiens	187-190
30815997-0	2019	Reduction of BMP6-induced bone formation by calcium phosphate in wild-type compared with nude mice.	calcium phosphate	44-61	bone morphogenetic protein 6	Mus musculus	13-17
30856221-4	2019	Specifically, the VEGF-derived "QK" peptide was synthesized with a heptaglutamate (E7) domain, a motif that has strong affinity for calcium phosphate graft materials.	calcium phosphate	132-149	vascular endothelial growth factor A	Homo sapiens	18-22
30813023-1	2019	The aim of this study was to find an optimum dose of the synthetic amorphous calcium phosphate (ACP) nanoparticles to be incorporated in resin-modified glass ionomer cements (RMGICs) for triggering the release of PO43-/Ca2+, alkaline phosphatase (ALP) activity and osteogenic differentiation of mesenchymal stem cells (hMSCs) without significantly affecting the essential properties of the cements.	calcium phosphate	77-94	alkaline phosphatase, placental	Homo sapiens	225-245
30813023-1	2019	The aim of this study was to find an optimum dose of the synthetic amorphous calcium phosphate (ACP) nanoparticles to be incorporated in resin-modified glass ionomer cements (RMGICs) for triggering the release of PO43-/Ca2+, alkaline phosphatase (ALP) activity and osteogenic differentiation of mesenchymal stem cells (hMSCs) without significantly affecting the essential properties of the cements.	calcium phosphate	77-94	alkaline phosphatase, placental	Homo sapiens	247-250
30882809-1	2019	Phosvitin phosphopeptides (PPP) effectively enhanced calcium bioavailability via inhibiting calcium-phosphate deposition.	calcium phosphate	92-109	casein kinase 2 beta	Homo sapiens	0-9
30901292-2	2019	MATERIALS & METHODS: Lipid-coated calcium phosphate nanoparticles were synthesized to deliver siRNAs against PD-1 and PD-L1 to TILs and breast cancer MCF-7 cells.	calcium phosphate	38-55	CD274 molecule	Homo sapiens	122-127
30901292-5	2019	RESULTS: Lipid-coated calcium phosphate nanoparticles effectively delivered siRNAs and silenced PD-1 and PD-L1sh expression.	calcium phosphate	22-39	CD274 molecule	Homo sapiens	105-110
30075952-6	2019	A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNgamma) from the pro-reparative stimulus simvastatin (SIMV).	calcium phosphate	13-30	interferon gamma	Homo sapiens	112-128
30075952-6	2019	A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNgamma) from the pro-reparative stimulus simvastatin (SIMV).	calcium phosphate	13-30	interferon gamma	Homo sapiens	130-138
30606550-0	2019	Improvement of calcium phosphate scaffold osteogenesis in vitro via combination of glutamate-modified BMP-2 peptides.	calcium phosphate	15-32	bone morphogenetic protein 2	Rattus norvegicus	102-107
30584645-2	2019	Therefore, the aim of this study was to evaluate associations between plasma sclerostin levels and calcium-phosphate disturbances, markers of bone turnover as well as inflammation in haemodialysis (HD) patients.	calcium phosphate	99-116	sclerostin	Homo sapiens	77-87
30573262-6	2019	The electrochemical results revealed that the pure calcium phosphate (CaP) coated implant material and the bare implant possess the highest resistivity to corrosion, while the modified calcium phosphate coating showed lower corrosion resistance by at least one order of magnitude.	calcium phosphate	51-68	CAP	Drosophila melanogaster	70-73
30703868-0	2019	Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1.	calcium phosphate	0-17	TNF superfamily member 11	Homo sapiens	35-40
30703868-0	2019	Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1.	calcium phosphate	0-17	dual specificity phosphatase 1	Homo sapiens	78-83
30777551-6	2019	SCUBE1 levels correlated with C-reactive protein in renal transplant recipients; magnesium in peritoneal dialysis patients; erythrocyte sedimentation rate in predialysis patients; and parathyroid hormone, platelet count, calcium-phosphate product, and calcium in hemo dialysis patients.	calcium phosphate	221-238	signal peptide, CUB domain and EGF like domain containing 1	Homo sapiens	0-6
30671652-17	2019	Thus, the in-situ transfection with BMP-7 and VEGF-A significantly improved the potential of calcium phosphate as pasty bone substitution material.	calcium phosphate	93-110	bone morphogenetic protein 7	Oryctolagus cuniculus	36-41
30671652-17	2019	Thus, the in-situ transfection with BMP-7 and VEGF-A significantly improved the potential of calcium phosphate as pasty bone substitution material.	calcium phosphate	93-110	vascular endothelial growth factor A	Oryctolagus cuniculus	46-52
30713844-7	2018	One such example is Fetuin-A, which is mainly produced in the liver and which forms calciprotein particles (CPPs), inhibiting growth of calcium-phosphate crystals in the blood and thereby preventing their soft tissue deposition.	calcium phosphate	136-153	alpha-2-HS-glycoprotein	Mus musculus	20-28
33405854-8	2019	Herein, utilization of CS is supposed to endow injectable calcium phosphate bone cements with enhanced osteogenic capacity and suitable physicochemical properties for numerous promising orthopedic applications.	calcium phosphate	58-75	citrate synthase	Homo sapiens	23-25
30446806-9	2019	Genetic polymorphisms decreasing CaSR expression could predispose individuals to stones because they may impair CaSR protective effects against precipitation of calcium phosphate and oxalate.	calcium phosphate	161-178	calcium sensing receptor	Homo sapiens	33-37
30446806-9	2019	Genetic polymorphisms decreasing CaSR expression could predispose individuals to stones because they may impair CaSR protective effects against precipitation of calcium phosphate and oxalate.	calcium phosphate	161-178	calcium sensing receptor	Homo sapiens	112-116
30671652-0	2019	A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: results of an in vivo study.	calcium phosphate	17-34	bone morphogenetic protein 7	Oryctolagus cuniculus	69-74
30671652-0	2019	A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: results of an in vivo study.	calcium phosphate	17-34	vascular endothelial growth factor A	Oryctolagus cuniculus	79-85
30671652-3	2019	24 New Zealand white rabbits were randomly divided into two groups: One group with BMP-7- and VEGF-A-encoding DNA on calcium phosphate nanoparticles and a control group with calcium phosphate nanoparticles only.	calcium phosphate	117-134	vascular endothelial growth factor A	Oryctolagus cuniculus	94-100
30213590-5	2018	RESULTS: In the liver of Cldn3-knockout mice, the paracellular phosphate ion permeability through hepatic tight junctions was significantly increased, resulting in calcium phosphate core formation.	calcium phosphate	164-181	claudin 3	Mus musculus	25-30
29952679-8	2018	CONCLUSION: In our experience, a low incidence of infection or CSF leaks has been noted after the use of calcium phosphate cement retromastoid cranioplasty.	calcium phosphate	105-122	colony stimulating factor 2	Homo sapiens	63-66
30588063-5	2019	CIMT was correlated with age (R=0.607; P<0.001), plasma albumin (R=-0.291, P=0.016), serum phosphate (R=-0.294, P=0.015), calcium-phosphate product (R=-0.284, P=0.011), and plasma high-sensitivity C-reactive protein (R=0.279, P=0.030).	calcium phosphate	125-142	CIMT	Homo sapiens	0-4
30588063-8	2019	In addition, older age, higher high-sensitivity C-reactive protein, and lower albumin, phosphate, and calcium-phosphate product levels were correlated with higher CIMT.	calcium phosphate	102-119	CIMT	Homo sapiens	163-167
29745811-9	2018	Calcium phosphate precipitates were observed on the surface of the ODAM-treated, but not BSA-treated collagen hydrogel after 24 hours in SBF.	calcium phosphate	0-17	odontogenic, ameloblast associated	Homo sapiens	67-71
29745814-0	2018	TRIP-1 in the extracellular matrix promotes nucleation of calcium phosphate polymorphs.	calcium phosphate	58-75	eukaryotic translation initiation factor 3 subunit I	Homo sapiens	0-6
29745814-5	2018	In this study, we demonstrate that varying concentrations of TRIP-1 can participate in the nucleation of calcium phosphate polymorphs.	calcium phosphate	105-122	eukaryotic translation initiation factor 3 subunit I	Homo sapiens	61-67
29745814-7	2018	Nucleation experiments performed on demineralized and deproteinized dentin wafer under physiological conditions and subsequent transmission electron microscope analysis of the deposits at the end of 7 and 14 days showed that TRIP-1 promoted the deposition of calcium phosphate mineral aggregates in the gap-overlap region of type I collagen.	calcium phosphate	259-276	eukaryotic translation initiation factor 3 subunit I	Homo sapiens	225-231
29730503-9	2018	Mechanistically, Fbln7 bound artificial calcium phosphate particles (aCPP) implicated in calcification and renal inflammation.	calcium phosphate	40-57	fibulin 7	Mus musculus	17-22
30081464-9	2018	Finally, our results showed the bone-forming capacity of hBMMSCs/beta-TCP since immunohistochemical expression of human osteocalcin was detected from week 7.	calcium phosphate	65-73	bone gamma-carboxyglutamate protein	Homo sapiens	120-131
30417599-4	2018	Herein, an in vitro enzymatic reaction strategy is reported for the generation of biomimic amorphous calcium phosphate (EACP) nanominerals by an alkaline phosphatase (ALP)-catalyzed hydrolysis of adenosine triphosphate (ATP) in a weakly alkalescent aqueous condition (pH 8.0-8.5), which is partially similar to the mitochondrial environment.	calcium phosphate	101-118	alkaline phosphatase, placental	Homo sapiens	145-165
30417599-4	2018	Herein, an in vitro enzymatic reaction strategy is reported for the generation of biomimic amorphous calcium phosphate (EACP) nanominerals by an alkaline phosphatase (ALP)-catalyzed hydrolysis of adenosine triphosphate (ATP) in a weakly alkalescent aqueous condition (pH 8.0-8.5), which is partially similar to the mitochondrial environment.	calcium phosphate	101-118	alkaline phosphatase, placental	Homo sapiens	167-170
30184740-0	2018	Prolonged release of bone morphogenetic protein-2 in vivo by gene transfection with DNA-functionalized calcium phosphate nanoparticle-loaded collagen scaffolds.	calcium phosphate	103-120	bone morphogenetic protein 2	Rattus norvegicus	21-49
30364715-1	2018	Amorphous calcium phosphate (Ca3(PO4)2xnH2O; n = 3-4.5; ACP) is a precursor phase of the mineral hydroxyapatite (Ca5(PO4)3(OH); HAP) that in natural settings occurs during both authigenic and biogenic mineral formation.	calcium phosphate	10-27	CPAT1	Homo sapiens	56-59
29316208-0	2018	Effect of bone sialoprotein coated three-dimensional printed calcium phosphate scaffolds on primary human osteoblasts.	calcium phosphate	61-78	integrin binding sialoprotein	Homo sapiens	10-27
29316208-4	2018	3D-plotted calcium phosphate cement (CPC) scaffolds were coated with BSP via physisorption.	calcium phosphate	11-28	integrin binding sialoprotein	Homo sapiens	69-72
29790251-0	2018	Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP-2-encapsulated nanoparticles and RGD for bone regeneration.	calcium phosphate	18-35	bone morphogenetic protein 2	Homo sapiens	66-71
29790251-2	2018	In the present study, we established chitosan/biphasic calcium phosphate (CS/BCP) scaffolds functionalized with Arg-Gly-Asp (RGD) and BMP-2-loaded nanoparticles.	calcium phosphate	55-72	citrate synthase	Homo sapiens	74-76
29790251-2	2018	In the present study, we established chitosan/biphasic calcium phosphate (CS/BCP) scaffolds functionalized with Arg-Gly-Asp (RGD) and BMP-2-loaded nanoparticles.	calcium phosphate	55-72	bone morphogenetic protein 2	Homo sapiens	134-139
30377580-0	2018	Hitting the Mark: Optimizing the Use of Calcium Phosphate Injections for the Treatment of Bone Marrow Lesions of the Proximal Tibia and Distal Femur.	calcium phosphate	40-57	microtubule affinity regulating kinase 1	Homo sapiens	12-16
30150536-2	2018	The application of nanotechnology and polymer development have enabled nanoparticles of amorphous calcium phosphate (NACP) and dimethylaminohexadecyl methacrylate (DMAHDM) to emerge as anti-caries strategies via resin-based dental materials.	calcium phosphate	98-115	synuclein alpha	Homo sapiens	117-121
30268068-13	2018	Calcium phosphate deposition and vascular calcification markers were downregulated in VSMC from Apoe-/-Mmp10-/- mice.	calcium phosphate	0-17	apolipoprotein E	Mus musculus	96-100
30268068-13	2018	Calcium phosphate deposition and vascular calcification markers were downregulated in VSMC from Apoe-/-Mmp10-/- mice.	calcium phosphate	0-17	matrix metallopeptidase 10	Mus musculus	103-108
30153499-1	2018	OBJECTIVES: The objectives were to develop a calcium (Ca) and phosphate (P) ion-rechargeable and protein-repellent adhesive containing nanoparticles of amorphous calcium phosphate (NACP) and 2-methacryloyloxyethyl phosphorylcholine (MPC), and investigate the MPC effects on ion recharge and re-releases for the first time.	calcium phosphate	162-179	synuclein alpha	Homo sapiens	181-185
30081464-10	2018	Conclusions: These results show that transplantation of hBMMSCs/beta-TCP in NOD/SCID mice are safe and effective, and might be applied to human bone diseases in future clinical trials.	calcium phosphate	64-72	atrophin 1	Homo sapiens	76-79
29744916-3	2018	Modified calcium phosphate method was used to transfect HORFC by PRPF31 siRNA.	calcium phosphate	9-26	pre-mRNA processing factor 31	Homo sapiens	65-71
29087028-4	2018	Finally, we deposited fine particles of amorphous calcium phosphate (PrAp) in the pores by soaking each substrate in SBF adjusted at pH 8.40, 25.0 C, and subsequently kept at 70.0 C for 24 h. By this treatment, we obtained the bioactive fiber-reinforced polymers.	calcium phosphate	50-67	S100 calcium binding protein A6	Homo sapiens	69-73
29193676-3	2018	The objective of this study was to develop a novel method of combining poly(amido amine) (PAMAM) with adhesive containing nanoparticles of amorphous calcium phosphate (NACP) for dentin remineralization in pH4 and CaP-lacking solution for the first time.	calcium phosphate	149-166	synuclein alpha	Homo sapiens	168-172
29744916-10	2018	The PRPF31 mRNA silencing with calcium phosphate had no effect on cell viability in the period of the experiment.	calcium phosphate	31-48	pre-mRNA processing factor 31	Homo sapiens	4-10
29554840-4	2018	The results of our study show that a lower single-dose local administration of bone morphogenetic protein-2 combined local usage of strontium-modified calcium phosphate cement can increase the healing of defects in OVX rats.	calcium phosphate	151-168	bone morphogenetic protein 2	Rattus norvegicus	79-107
29554840-5	2018	Furthermore, treatments with single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement showed a stronger effect on accelerating the local bone formation than calcium phosphate cement and strontium-modified calcium phosphate cement used alone.	calcium phosphate	213-230	bone morphogenetic protein 2	Rattus norvegicus	65-93
29554840-5	2018	Furthermore, treatments with single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement showed a stronger effect on accelerating the local bone formation than calcium phosphate cement and strontium-modified calcium phosphate cement used alone.	calcium phosphate	213-230	bone morphogenetic protein 2	Rattus norvegicus	65-93
29892913-1	2018	This study aimed to develop of a rapid and effective method to occlude dentinal tubules using carboxymethyl chitosan and lysozyme (CMC/LYZ) nanogels with encapsulated amorphous calcium phosphate (ACP) based on the transformation of ACP to HAP.	calcium phosphate	177-194	lysozyme	Homo sapiens	135-138
29697113-0	2018	Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors.	calcium phosphate	56-73	asparaginase and isoaspartyl peptidase 1	Homo sapiens	12-26
29574131-2	2018	D/PSP@CQ/CaP was prepared by coprecipitating chloroquine phosphate (CQ) with calcium chloride, in the form of chloroquine-calcium phosphate coprecipitate (CQ/CaP), onto the surface of a deep-tumor-penetrating doxorubicine (DOX)-loading core particle (named as "D/PSP").	calcium phosphate	122-139	persephin	Mus musculus	2-5
29713719-0	2018	Osteocalcin facilitates calcium phosphate ion complex growth as revealed by free energy calculation.	calcium phosphate	24-41	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
29713719-3	2018	It is observed that osteocalcin (OCN), an important non-collagenous protein involved in regulating bone formation, promotes the growth of nanosized calcium phosphate (CaP) ion clusters from a supersaturated solution.	calcium phosphate	148-165	bone gamma-carboxyglutamate protein	Homo sapiens	20-31
29713719-3	2018	It is observed that osteocalcin (OCN), an important non-collagenous protein involved in regulating bone formation, promotes the growth of nanosized calcium phosphate (CaP) ion clusters from a supersaturated solution.	calcium phosphate	148-165	bone gamma-carboxyglutamate protein	Homo sapiens	33-36
29713719-3	2018	It is observed that osteocalcin (OCN), an important non-collagenous protein involved in regulating bone formation, promotes the growth of nanosized calcium phosphate (CaP) ion clusters from a supersaturated solution.	calcium phosphate	167-170	bone gamma-carboxyglutamate protein	Homo sapiens	20-31
29713719-3	2018	It is observed that osteocalcin (OCN), an important non-collagenous protein involved in regulating bone formation, promotes the growth of nanosized calcium phosphate (CaP) ion clusters from a supersaturated solution.	calcium phosphate	167-170	bone gamma-carboxyglutamate protein	Homo sapiens	33-36
29626696-8	2018	When applied to hPDCs seeded onto calcium phosphate scaffolds, the supplements significantly induced VEGF secretion in vitro, and promoted higher vascularization upon ectopic implantation in nude mice shown by an increase of CD31 positive blood vessels within the scaffolds.	calcium phosphate	34-51	vascular endothelial growth factor A	Mus musculus	101-105
29626696-8	2018	When applied to hPDCs seeded onto calcium phosphate scaffolds, the supplements significantly induced VEGF secretion in vitro, and promoted higher vascularization upon ectopic implantation in nude mice shown by an increase of CD31 positive blood vessels within the scaffolds.	calcium phosphate	34-51	platelet/endothelial cell adhesion molecule 1	Mus musculus	225-229
29526668-5	2018	Nanoparticles of amorphous calcium phosphate (NACP) were synthesized using a spray-drying technique.	calcium phosphate	27-44	synuclein alpha	Homo sapiens	46-50
29379925-1	2018	We investigate "Posner molecules", calcium phosphate clusters with chemical formula Ca9(PO4)6.	calcium phosphate	35-52	carbonic anhydrase 9	Homo sapiens	84-87
29477893-10	2018	Moreover, the immobilization of DMP1 peptides through the spacers led to the formation of calcium phosphate minerals with a Ca/P ratio near to that of hydroxyapatite.	calcium phosphate	90-107	dentin matrix acidic phosphoprotein 1	Homo sapiens	32-36
30270749-10	2018	In groups receiving calcium phosphate implants loaded with 10 mug BMP2 and 1 mug BMP2/10 mug L51P, the volume of bone was increased and betaTCP was decreased compared to groups receiving implants with 1 mug BMP2 and 10 mug L51P.	calcium phosphate	20-37	bone morphogenetic protein 2	Homo sapiens	66-76
30270749-10	2018	In groups receiving calcium phosphate implants loaded with 10 mug BMP2 and 1 mug BMP2/10 mug L51P, the volume of bone was increased and betaTCP was decreased compared to groups receiving implants with 1 mug BMP2 and 10 mug L51P.	calcium phosphate	20-37	bone morphogenetic protein 2	Homo sapiens	66-70
30270749-10	2018	In groups receiving calcium phosphate implants loaded with 10 mug BMP2 and 1 mug BMP2/10 mug L51P, the volume of bone was increased and betaTCP was decreased compared to groups receiving implants with 1 mug BMP2 and 10 mug L51P.	calcium phosphate	20-37	bone morphogenetic protein 2	Homo sapiens	81-85
29398109-2	2018	The objective of this study was to develop a long-term remineralization method to via poly(amido amine) (PAMAM) and rechargeable composite containing nanoparticles of amorphous calcium phosphate (NACP) after fluid challenges for the first time.	calcium phosphate	177-194	synuclein alpha	Homo sapiens	196-200
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	RUNX family transcription factor 2	Homo sapiens	111-116
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	Sp7 transcription factor	Homo sapiens	140-143
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	Sp7 transcription factor	Homo sapiens	145-148
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	collagen type I alpha 1 chain	Homo sapiens	151-174
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	collagen type I alpha 1 chain	Homo sapiens	176-182
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	bone gamma-carboxyglutamate protein	Homo sapiens	194-239
29325202-5	2018	The tubular calcium phosphate induces the expression of osteogenic genes (runt-related transcription factor 2 (RUNX2), transcription factor SP7 (SP7), collagen type 1 alpha 1 (COL1A1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP)) and promotes the formation of mineral nodules in preosteoblast cultures comparable to an apatitic calcium phosphate phase.	calcium phosphate	12-29	bone gamma-carboxyglutamate protein	Homo sapiens	241-246
29355717-0	2018	Localization and promotion of recombinant human bone morphogenetic protein-2 bioactivity on extracellular matrix mimetic chondroitin sulfate-functionalized calcium phosphate cement scaffolds.	calcium phosphate	156-173	bone morphogenetic protein 2	Homo sapiens	48-76
29551896-0	2018	Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy.	calcium phosphate	81-98	beclin 1, autophagy related	Mus musculus	24-32
29599617-4	2018	RANKL-induced bone resorption was assessed by the measurement of pit formation using calcium phosphate-labeled fluorescent polyanionic molecules in RAW264.7 cells as osteoclast precursors.	calcium phosphate	85-102	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	0-5
29581559-0	2018	Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation.	calcium phosphate	38-55	elastin	Homo sapiens	66-73
29551896-4	2018	The objective of this study was to enhance the anticancer effect of FTY720 in hepatocellular carcinoma (HCC) by targeted co-delivery of FTY720 and Beclin 1 siRNA using calcium phosphate (CaP) nanoparticles (NPs).	calcium phosphate	168-185	beclin 1, autophagy related	Mus musculus	147-155
29551896-4	2018	The objective of this study was to enhance the anticancer effect of FTY720 in hepatocellular carcinoma (HCC) by targeted co-delivery of FTY720 and Beclin 1 siRNA using calcium phosphate (CaP) nanoparticles (NPs).	calcium phosphate	187-190	beclin 1, autophagy related	Mus musculus	147-155
29225177-4	2018	Bovine serum albumin (BSA), as a model protein drug, was loaded in the CHI-g-P(SPMA)/calcium phosphate hybrid.	calcium phosphate	85-102	albumin	Homo sapiens	7-20
28885731-3	2018	TRAIL pDNA was encapsulated in a pH stimuli-responsive calcium phosphate (CaP) core, and protamine was added to facilitate nuclear delivery of pDNA.	calcium phosphate	55-72	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	0-5
28885731-3	2018	TRAIL pDNA was encapsulated in a pH stimuli-responsive calcium phosphate (CaP) core, and protamine was added to facilitate nuclear delivery of pDNA.	calcium phosphate	74-77	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	0-5
29171990-8	2018	Aluminum compounds adjuvants (nanoparticles and microparticles formulation) and microparticles calcium phosphate adjuvant induce TH2 response, while nanoparticles calcium phosphate and microparticles aluminum compounds adjuvants stimulate TH1 response.	calcium phosphate	95-112	heart and neural crest derivatives expressed 2	Mus musculus	129-132
29467661-5	2017	This review describes original research on coral-derived calcium phosphate-based macroporous constructs showing that the formation of bone is independent of the exogenous application of the osteogenic soluble signals of the TGF-beta supergene family.	calcium phosphate	57-74	transforming growth factor beta 1	Homo sapiens	224-232
29116357-3	2018	METHODS: Calcium phosphate cement (CPC) was redesigned by incorporating starch and BaSO4 (new cement named as CPB).	calcium phosphate	9-26	carboxypeptidase B1	Rattus norvegicus	110-113
29274344-0	2018	Calcium phosphate particles stimulate interleukin-1beta release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.	calcium phosphate	0-17	interleukin 1 beta	Homo sapiens	38-55
29274344-0	2018	Calcium phosphate particles stimulate interleukin-1beta release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.	calcium phosphate	0-17	spleen associated tyrosine kinase	Homo sapiens	116-138
29274344-9	2018	Furthermore, CaP particle treatment stimulated exosome secretion by VSMCs in a SYK-dependent manner, while the exosome-release inhibitor spiroepoxide reduced IL-1beta release.	calcium phosphate	13-16	spleen associated tyrosine kinase	Homo sapiens	79-82
29274344-10	2018	CONCLUSIONS: CaP particles stimulate SYK and caspase-1 activation in VSMCs, leading to the release of IL-1beta, at least in part via exosomes.	calcium phosphate	13-16	spleen associated tyrosine kinase	Homo sapiens	37-40
29274344-10	2018	CONCLUSIONS: CaP particles stimulate SYK and caspase-1 activation in VSMCs, leading to the release of IL-1beta, at least in part via exosomes.	calcium phosphate	13-16	caspase 1	Homo sapiens	45-54
29274344-10	2018	CONCLUSIONS: CaP particles stimulate SYK and caspase-1 activation in VSMCs, leading to the release of IL-1beta, at least in part via exosomes.	calcium phosphate	13-16	interleukin 1 beta	Homo sapiens	102-110
29593135-6	2018	Higher solubility was also observed in the small intestine of rats fed a micellar calcium phosphate casein-phosphopeptide(MCP-CPP)complex prepared from milk compared to that in rats fed insoluble whey calcium.	calcium phosphate	82-99	CD46 molecule	Rattus norvegicus	122-125
29040148-0	2018	Long-Term Effects of Bone Morphogenetic Protein-2-Loaded Calcium Phosphate on Maxillary Sinus Lift Surgery for Delayed and Simultaneous Dental Implantation.	calcium phosphate	57-74	bone morphogenetic protein 2	Homo sapiens	21-49
29040148-3	2018	In this study, 20 patients received MSLS with graft of bone morphogenetic protein 2 (BMP2)-loaded calcium phosphate.	calcium phosphate	98-115	bone morphogenetic protein 2	Homo sapiens	55-83
29040148-3	2018	In this study, 20 patients received MSLS with graft of bone morphogenetic protein 2 (BMP2)-loaded calcium phosphate.	calcium phosphate	98-115	bone morphogenetic protein 2	Homo sapiens	85-89
29040148-9	2018	These findings implied that BMP2-loaded calcium phosphate may be a suitable material for MSLS, especially for patients with minimal bone height.	calcium phosphate	40-57	bone morphogenetic protein 2	Homo sapiens	28-32
29031993-1	2018	BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (eg, GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty and kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and to support complete bone regeneration.	calcium phosphate	112-129	growth/differentiation factor 5	Ovis aries	89-93
28752471-0	2018	Calcium Phosphate Particles as Pulmonary Delivery System for Interferon-alpha in Mice.	calcium phosphate	0-17	interferon alpha	Mus musculus	61-77
28752471-3	2018	The purpose of this study was to evaluate the potential of proprietary calcium phosphate (CaP) particles to deliver biologically active interferon alpha (IFNalpha) via the lungs into systemic circulation.	calcium phosphate	71-88	interferon alpha	Mus musculus	136-152
28752471-3	2018	The purpose of this study was to evaluate the potential of proprietary calcium phosphate (CaP) particles to deliver biologically active interferon alpha (IFNalpha) via the lungs into systemic circulation.	calcium phosphate	71-88	interferon alpha	Mus musculus	154-162
29080455-0	2018	In vitro and in vivo toxicity assessment of alginate/eudragit S 100-enclosed chitosan-calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs).	calcium phosphate	86-103	lactotransferrin	Bos taurus	133-144
30541004-14	2018	Staining and quantification of calcium phosphate precipitates revealed a significantly higher mineralization potential of MACS separated MSCA-1+ and CD146- CPCs, compared to their respective counterparts.	calcium phosphate	31-48	melanoma cell adhesion molecule	Homo sapiens	149-154
30541004-15	2018	FACS sorted CPCs displayed earlier mineralization in both MSCA-1+ fractions (d13), while later (d28) only the CD146+/MSCA-1- fraction had a significantly lower calcium phosphate concentration compared to all other fractions.	calcium phosphate	160-177	melanoma cell adhesion molecule	Homo sapiens	110-115
29325620-4	2018	In the past years PFBC causal mutations have been discovered in genes related to calcium phosphate homeostasis (SLC20A2, XPR1) and in genes involved with endothelial function and integrity (PDGFB, PDGFRB).	calcium phosphate	81-98	solute carrier family 20 member 2	Homo sapiens	112-119
28701073-1	2018	The purposes of this study are to confirm the role of Fibroblast Growth Factor-2 (FGF-2) in bone regeneration by adding various concentrations of FGF-2 to the collagen membrane and applying it to the Biphasic Calcium Phosphate (BCP) bone graft site for guided bone regeneration, to explore the potential of collagen membrane as FGF-2 carrier, and to determine the optimum FGF concentration for enhancement of bone regeneration.	calcium phosphate	209-226	fibroblast growth factor 2	Oryctolagus cuniculus	54-80
28701073-1	2018	The purposes of this study are to confirm the role of Fibroblast Growth Factor-2 (FGF-2) in bone regeneration by adding various concentrations of FGF-2 to the collagen membrane and applying it to the Biphasic Calcium Phosphate (BCP) bone graft site for guided bone regeneration, to explore the potential of collagen membrane as FGF-2 carrier, and to determine the optimum FGF concentration for enhancement of bone regeneration.	calcium phosphate	209-226	fibroblast growth factor 2	Oryctolagus cuniculus	82-87
32264425-4	2017	In addition, immobilization of angiopoietin-1 (Ang-1) via physisorption within the beta-TCP + ND scaffold retained the bioactivity of the growth factor.	calcium phosphate	83-91	angiopoietin-1	Ovis aries	31-45
28942129-3	2017	In the present study, biphasic calcium phosphate (BCP) bioceramics composed of micro-whiskers and nanoparticles hybrid-structured surface (hBCP) were fabricated via a hydrothermal reaction.	calcium phosphate	31-48	opsin 1, short wave sensitive	Homo sapiens	50-53
28942129-3	2017	In the present study, biphasic calcium phosphate (BCP) bioceramics composed of micro-whiskers and nanoparticles hybrid-structured surface (hBCP) were fabricated via a hydrothermal reaction.	calcium phosphate	31-48	opsin 1, short wave sensitive	Homo sapiens	139-143
29568455-2	2017	Here, we fabricated spherical polydopamine/mesoporous calcium phosphate hollow JNPs (PDA/mCaP H-JNPs) via a novel and facile approach.	calcium phosphate	54-71	non-SMC condensin I complex, subunit H	Mus musculus	89-95
28537482-0	2017	* Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold.	calcium phosphate	103-120	bone morphogenetic protein 2	Homo sapiens	51-79
28537482-7	2017	PDGF and BMP-2 were sequentially released from this hybrid calcium phosphate/alginate scaffold with the desired 3-day overlap in PDGF to BMP-2 delivery.	calcium phosphate	59-76	bone morphogenetic protein 2	Homo sapiens	9-14
28537482-7	2017	PDGF and BMP-2 were sequentially released from this hybrid calcium phosphate/alginate scaffold with the desired 3-day overlap in PDGF to BMP-2 delivery.	calcium phosphate	59-76	bone morphogenetic protein 2	Homo sapiens	137-142
29113568-0	2017	Combined delivery of bone morphogenetic protein-2 and insulin-like growth factor-1 from nano-poly (gamma-glutamic acid)/beta-tricalcium phosphate-based calcium phosphate cement and its effect on bone regeneration in vitro.	calcium phosphate	128-145	insulin-like growth factor 1	Mus musculus	54-82
28866158-0	2017	Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditions.	calcium phosphate	85-102	bone morphogenetic protein 2	Homo sapiens	66-71
28741427-12	2017	The injectable beta-TCP bone grafts used in this study were effective in peri-implant bone generation under osteoporotic conditions, and their efficiency was enhanced at 5 mug BMP-2 compared with higher concentrations of BMP-2.	calcium phosphate	15-23	bone morphogenetic protein 2	Canis lupus familiaris	176-181
28741427-12	2017	The injectable beta-TCP bone grafts used in this study were effective in peri-implant bone generation under osteoporotic conditions, and their efficiency was enhanced at 5 mug BMP-2 compared with higher concentrations of BMP-2.	calcium phosphate	15-23	bone morphogenetic protein 2	Canis lupus familiaris	221-226
28694330-5	2017	One of these phosphorylations (phospho-Y341) is required for C-Raf dimerization, and this action can be replicated by phosphomimetic mutants both in vivo and in vitro The role of the phosphorylation of Y341 in promoting Raf dimerization is distinct from its well-known function in facilitating S338 phosphorylation.	calcium phosphate	294-298	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	61-66
29631967-6	2018	SCP  involves injecting calcium phosphate into bone marrow lesions to stimulate long-term bone repair.	calcium phosphate	24-41	urocortin 3	Homo sapiens	0-3
29317815-0	2018	Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities.	calcium phosphate	84-101	negative elongation factor complex member C/D, Th1l	Mus musculus	159-162
29317815-5	2018	The materials and method used for complexation influenced the degree of IFN-beta induction: ds CpG-B72-PD entrapped by calcium phosphate (CaP) (ds CpG-B72-PD/CaP) showed a higher induction capacity than ds CpG-B72-PD adsorbed onto the CaP surface.	calcium phosphate	119-136	interferon beta 1, fibroblast	Mus musculus	72-80
28963016-0	2017	Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation.	calcium phosphate	76-93	toll like receptor 3	Homo sapiens	16-19
28963016-4	2017	A modular system where the immunoactive toll-like-receptor ligand 3 (TLR-3) poly(I:C) was incorporated into calcium phosphate nanoparticles was developed.	calcium phosphate	108-125	toll like receptor 3	Homo sapiens	40-67
28963016-4	2017	A modular system where the immunoactive toll-like-receptor ligand 3 (TLR-3) poly(I:C) was incorporated into calcium phosphate nanoparticles was developed.	calcium phosphate	108-125	toll like receptor 3	Homo sapiens	69-74
29153180-9	2017	Up to the 1950s, research on dairy chemistry was mostly focused on topics such as protein fractionation, heat stability, acid-base buffering, freezing point, and the nature of the calcium phosphate present in milk.	calcium phosphate	180-197	Weaning weight-maternal milk	Bos taurus	209-213
28946792-0	2017	* Calvarial Bone Regeneration Is Enhanced by Sequential Delivery of FGF-2 and BMP-2 from Layer-by-Layer Coatings with a Biomimetic Calcium Phosphate Barrier Layer.	calcium phosphate	131-148	fibroblast growth factor 2	Mus musculus	68-73
29379633-0	2018	In vitro and in vivo anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules.	calcium phosphate	75-92	lactotransferrin	Bos taurus	110-121
29088242-2	2017	Due to its high affinity for calcium phosphate, fetuin-A is highly abundant in mineralized bone matrix.	calcium phosphate	29-46	alpha-2-HS-glycoprotein	Mus musculus	48-56
29158840-5	2017	Considering that the drawback of poor cellular permeability and rapid degradation in vivo limited ODNs" further clinical applications, we developed a biomimetic calcium phosphate-reconstituted low density lipoprotein nanovehicle (CaP@LDL) that would serve as a "Trojan horse" to carry STAT3-decoy ODNs into tumor cells and then regulate TRAIL-induced apoptosis.	calcium phosphate	161-178	signal transducer and activator of transcription 3	Equus caballus	285-290
28887583-6	2017	Pre-miR-608 transfection to the cell lines was done by calcium phosphate method.	calcium phosphate	55-72	microRNA 608	Homo sapiens	4-11
28629083-1	2017	Insulin-loaded calcium phosphate nanoparticles have been proposed as a potential drug delivery system for the oral treatment of diabetes and to stimulate bone cell proliferation and bone mineralization.	calcium phosphate	15-32	insulin	Homo sapiens	0-7
28912673-0	2017	Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.	calcium phosphate	81-98	superoxide dismutase 1, soluble	Mus musculus	26-30
32264425-4	2017	In addition, immobilization of angiopoietin-1 (Ang-1) via physisorption within the beta-TCP + ND scaffold retained the bioactivity of the growth factor.	calcium phosphate	83-91	angiopoietin-1	Ovis aries	47-52
32264425-6	2017	The biological responses of the beta-TCP + ND scaffold with and without Ang-1 were studied in a sheep calvaria critical size defect model showing that the beta-TCP + ND scaffold improved the blood vessel ingrowth and the beta-TCP + ND + ND + Ang-1 scaffold further promoted vascularization and new bone formation.	calcium phosphate	155-163	angiopoietin-1	Ovis aries	72-77
32264425-6	2017	The biological responses of the beta-TCP + ND scaffold with and without Ang-1 were studied in a sheep calvaria critical size defect model showing that the beta-TCP + ND scaffold improved the blood vessel ingrowth and the beta-TCP + ND + ND + Ang-1 scaffold further promoted vascularization and new bone formation.	calcium phosphate	155-163	angiopoietin-1	Ovis aries	242-247
32264425-6	2017	The biological responses of the beta-TCP + ND scaffold with and without Ang-1 were studied in a sheep calvaria critical size defect model showing that the beta-TCP + ND scaffold improved the blood vessel ingrowth and the beta-TCP + ND + ND + Ang-1 scaffold further promoted vascularization and new bone formation.	calcium phosphate	155-163	angiopoietin-1	Ovis aries	72-77
32264425-6	2017	The biological responses of the beta-TCP + ND scaffold with and without Ang-1 were studied in a sheep calvaria critical size defect model showing that the beta-TCP + ND scaffold improved the blood vessel ingrowth and the beta-TCP + ND + ND + Ang-1 scaffold further promoted vascularization and new bone formation.	calcium phosphate	155-163	angiopoietin-1	Ovis aries	242-247
28703639-0	2017	Physicochemical regulation of TGF and VEGF delivery from mesoporous calcium phosphate bone substitutes.	calcium phosphate	68-85	vascular endothelial growth factor A	Homo sapiens	38-42
28532013-8	2017	CONCLUSION: Knockout of TRPV1 in mice could reduce algesia and induce the stronger athletic ability of mice, causing better osteoinductivity of Ca-P biomaterials both in TRPV1-/- mice and running mice; according to this, we want to offer a proposal to patients who suffer from bone defects and artificial bone transplantation: do moderate exercise, don"t convalesce all the time.	calcium phosphate	144-148	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-29
28532084-0	2017	Incorporation of BMP-2 loaded collagen conjugated BCP granules in calcium phosphate cement based injectable bone substitutes for improved bone regeneration.	calcium phosphate	66-83	bone morphogenetic protein 2	Homo sapiens	17-22
28860767-0	2017	VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer.	calcium phosphate	57-74	vascular endothelial growth factor A	Homo sapiens	0-4
28363650-2	2017	This study investigated the role of phosphorylation of phosvitin in the phase transformation of calcium phosphate in the mineralization solution.	calcium phosphate	96-113	casein kinase 2 beta	Homo sapiens	55-64
28589918-3	2017	In this investigation, a novel cryogenic 3D printing technique was investigated and developed for producing hierarchical porous and recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded calcium phosphate (Ca-P) nanoparticle/poly(L-lactic acid) nanocomposite scaffolds, in which the Ca-P nanoparticle-incorporated scaffold layer and rhBMP-2-encapsulated scaffold layer were deposited alternatingly using different types of emulsions as printing inks.	calcium phosphate	196-213	bone morphogenetic protein 2	Homo sapiens	150-178
28526130-4	2017	Therefore, the objective of this study was to investigate a novel method of combining poly(amido amine) (PAMAM) with a composite of nanoparticles of amorphous calcium phosphate (NACP) on dentin remineralization in an acidic solution without Ca and P ions for the first time.	calcium phosphate	159-176	synuclein alpha	Homo sapiens	178-182
28706493-2	2017	Notably, P173 and LRAP(+P) stabilize amorphous calcium phosphate (ACP) and inhibit hydroxyapatite (HA) formation, while non-phosphorylated counterparts (rP172, LRAP(-P)) guide the growth of ordered bundles of HA crystals.	calcium phosphate	47-64	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	9-13
28706493-2	2017	Notably, P173 and LRAP(+P) stabilize amorphous calcium phosphate (ACP) and inhibit hydroxyapatite (HA) formation, while non-phosphorylated counterparts (rP172, LRAP(-P)) guide the growth of ordered bundles of HA crystals.	calcium phosphate	47-64	endoplasmic reticulum aminopeptidase 2	Homo sapiens	18-22
28706493-3	2017	Based on these findings, we hypothesize that the phosphorylation of full-length amelogenin and LRAP induces conformational changes that critically affect its capacity to interact with forming calcium phosphate mineral phases.	calcium phosphate	192-209	endoplasmic reticulum aminopeptidase 2	Homo sapiens	95-99
28763481-0	2017	Osteoclastic differentiation and resorption is modulated by bioactive metal ions Co2+, Cu2+ and Cr3+ incorporated into calcium phosphate bone cements.	calcium phosphate	119-136	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	96-99
28763481-13	2017	In conclusion Cr3+ doped calcium phosphate cements are an innovative cement modification because of their high cytocompatibility and support of active resorption by osteoclasts.	calcium phosphate	25-42	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	14-17
28423353-8	2017	Using calcium phosphate hybrid micelles as an RNAi delivery system, silencing of PRDM14 expression by chimera RNAi reduced tumor size and metastasis in vivo without causing adverse effects.	calcium phosphate	6-23	PR/SET domain 14	Homo sapiens	81-87
28713112-1	2017	AIM: This study aims to investigate the effect of casein phos-phopeptide-amorphous calcium phosphate and three calcium phosphate (CPP-ACP and TCP) on increasing the microhardness of human enamel after induction of erosion.	calcium phosphate	111-128	serine peptidase inhibitor Kazal type 1	Homo sapiens	130-145
28585833-0	2017	Energetic Basis for Inhibition of Calcium Phosphate Biomineralization by Osteopontin.	calcium phosphate	34-51	secreted phosphoprotein 1	Homo sapiens	73-84
28585833-3	2017	Here we demonstrate the thermodynamic basis for how OPN sequences regulate the onset of Ca-P mineral formation on lipid rafts as a model membrane.	calcium phosphate	88-92	secreted phosphoprotein 1	Homo sapiens	52-55
30603507-0	2017	Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering.	calcium phosphate	52-69	bone morphogenetic protein 2	Homo sapiens	138-166
30603507-3	2017	The aim of this study was to fabricate and characterize a novel calcium phosphate/polyphosphazenes porous scaffold for the sustained release of bone morphogenetic protein 2 in bone tissue engineering.	calcium phosphate	64-81	bone morphogenetic protein 2	Homo sapiens	144-172
30603507-5	2017	Calcium phosphate porous samples were prepared from hydroxyapatite nanoparticles and naphthalene using the sintering method at 1250  C before being composited with poly(dimethylaminoethanol)phosphazenes containing chitosan microspheres loaded with bone morphogenetic protein 2.	calcium phosphate	0-17	bone morphogenetic protein 2	Homo sapiens	248-276
28589918-3	2017	In this investigation, a novel cryogenic 3D printing technique was investigated and developed for producing hierarchical porous and recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded calcium phosphate (Ca-P) nanoparticle/poly(L-lactic acid) nanocomposite scaffolds, in which the Ca-P nanoparticle-incorporated scaffold layer and rhBMP-2-encapsulated scaffold layer were deposited alternatingly using different types of emulsions as printing inks.	calcium phosphate	215-219	bone morphogenetic protein 2	Homo sapiens	150-178
28589918-3	2017	In this investigation, a novel cryogenic 3D printing technique was investigated and developed for producing hierarchical porous and recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded calcium phosphate (Ca-P) nanoparticle/poly(L-lactic acid) nanocomposite scaffolds, in which the Ca-P nanoparticle-incorporated scaffold layer and rhBMP-2-encapsulated scaffold layer were deposited alternatingly using different types of emulsions as printing inks.	calcium phosphate	292-296	bone morphogenetic protein 2	Homo sapiens	150-178
28279618-0	2017	Aptamer-Conjugated Calcium Phosphate Nanoparticles for Reducing Diabetes Risk via Retinol Binding Protein 4 Inhibition.	calcium phosphate	19-36	retinol binding protein 4	Homo sapiens	82-107
28279618-1	2017	OBJECTIVES: Inhibition of the binding of retinol to its carrier, retinol binding protein 4, is a new strategy for treating type 2 diabetes; for this purpose, we have provided an aptamer-functionalized multishell calcium phosphate nanoparticle.	calcium phosphate	212-229	retinol binding protein 4	Homo sapiens	65-90
28521505-0	2017	Orientation and conformation of osteocalcin adsorbed onto calcium phosphate and silica surfaces.	calcium phosphate	58-75	bone gamma-carboxyglutamate protein	Homo sapiens	32-43
28389833-0	2017	Immunohistochemistry evaluation of BMP-2 with beta-tricalcium phosphate matrix, polylactic and polyglycolic acid gel, and calcium phosphate cement in rats.	calcium phosphate	54-71	bone morphogenetic protein 2	Rattus norvegicus	35-40
27771827-0	2017	Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP).	calcium phosphate	172-189	bone morphogenetic protein 1	Homo sapiens	18-44
28489075-4	2017	Apolipoprotein E3-reconstituted high-density lipoprotein is used to encapsulate the siRNA-loaded calcium phosphate core and facilitate it to penetrate the blood-brain barrier, thus targeting the glioblastoma cells in a macropinocytosis-dependent manner.	calcium phosphate	97-114	apolipoprotein E	Homo sapiens	0-17
28371683-2	2017	ALP hydrolyses inorganic pyrophosphate, which is a strong inhibitor of calcium phosphate deposition.	calcium phosphate	71-88	alkaline phosphatase, placental	Homo sapiens	0-3
28356216-1	2017	OBJECTIVE: A new adhesive containing nanoparticles of amorphous calcium phosphate (NACP) with calcium (Ca) and phosphate (P) ion rechargeability was recently developed; however, it was not antibacterial.	calcium phosphate	64-81	synuclein alpha	Homo sapiens	83-87
28445750-4	2017	A notable property of highly phosphorylated isoforms of osteopontin is their ability to sequester nanoclusters of calcium phosphate to form a core-shell structure, in a fluid that is supersaturated but stable.	calcium phosphate	114-131	secreted phosphoprotein 1	Homo sapiens	56-67
28260724-3	2017	NLRP3 inflammasomes are activated by various danger signals, such as cholesterol crystals, calcium phosphate crystals, and oxidized low-density lipoprotein in macrophages, to initiate inflammatory responses in the atherosclerotic lesion.	calcium phosphate	91-108	NLR family pyrin domain containing 3	Homo sapiens	0-5
28448530-2	2017	We previously reported that renal calcium phosphate deposits persist and/or reappear in older Npt2a-/- mice supplemented with phosphate despite resolution of hypercalciuria while no deposits are seen in wild-type (WT) mice on the same diet.	calcium phosphate	34-51	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	94-99
28448530-3	2017	Addition of calcium to their diets further increased calcium phosphate deposits in Npt2a-/-, but not WT mice.	calcium phosphate	53-70	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	83-88
28361415-1	2017	The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-beta2 (TGF-beta2) in chondroblasts during the two weeks after surgery.	calcium phosphate	225-242	vascular endothelial growth factor A	Rattus norvegicus	45-79
28338064-0	2017	Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.	calcium phosphate	127-144	Wnt family member 2	Rattus norvegicus	48-51
28338064-0	2017	Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.	calcium phosphate	127-144	catenin beta 1	Rattus norvegicus	52-64
28487820-0	2017	Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization.	calcium phosphate	138-155	statherin	Homo sapiens	108-117
28487820-5	2017	The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically bind to and nucleate calcium phosphate.	calcium phosphate	145-162	statherin	Homo sapiens	73-82
28487820-7	2017	Mineralization of the resulting hybrid elastin-like-statherin recombinamer hydrogels with calcium phosphate is described.	calcium phosphate	90-107	statherin	Homo sapiens	52-61
28017869-7	2017	Calcium phosphate-coated scaffolds induced the expression of osteocalcin by hOBs when maintained in osteogenic conditions.	calcium phosphate	0-17	bone gamma-carboxyglutamate protein	Homo sapiens	61-72
28017869-7	2017	Calcium phosphate-coated scaffolds induced the expression of osteocalcin by hOBs when maintained in osteogenic conditions.	calcium phosphate	0-17	leptin	Homo sapiens	76-80
26970206-2	2017	Given the limitations of using autologous bone, bone morphogenetic protein-2 (BMP2)-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particles (BMP2-cop.BioCaP) have been developed as a potential osteoinducer.	calcium phosphate	136-153	bone morphogenetic protein 2	Rattus norvegicus	48-76
26970206-2	2017	Given the limitations of using autologous bone, bone morphogenetic protein-2 (BMP2)-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particles (BMP2-cop.BioCaP) have been developed as a potential osteoinducer.	calcium phosphate	136-153	bone morphogenetic protein 2	Rattus norvegicus	78-82
26970206-2	2017	Given the limitations of using autologous bone, bone morphogenetic protein-2 (BMP2)-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particles (BMP2-cop.BioCaP) have been developed as a potential osteoinducer.	calcium phosphate	136-153	bone morphogenetic protein 2	Rattus norvegicus	165-169
28361415-1	2017	The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-beta2 (TGF-beta2) in chondroblasts during the two weeks after surgery.	calcium phosphate	225-242	vascular endothelial growth factor A	Rattus norvegicus	81-85
28326227-0	2017	Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles.	calcium phosphate	60-77	HtrA serine peptidase 1	Homo sapiens	23-28
28202997-0	2017	[A novel tissue-engineered bone constructed by using human adipose-derived stem cells and biomimetic calcium phosphate scaffold coprecipitated with bone morphogenetic protein-2].	calcium phosphate	101-118	bone morphogenetic protein 2	Homo sapiens	148-176
28202997-1	2017	OBJECTIVE: To construct a novel biomimetic calcium phosphate (BioCaP) scaffold loaded with bone morphogenetic protein-2 (BMP-2), and to investigate its role in the osteogenesis of human adipose-derived stem cells (hASCs) in vitro and in vivo.	calcium phosphate	43-60	bone morphogenetic protein 2	Homo sapiens	91-119
28202997-1	2017	OBJECTIVE: To construct a novel biomimetic calcium phosphate (BioCaP) scaffold loaded with bone morphogenetic protein-2 (BMP-2), and to investigate its role in the osteogenesis of human adipose-derived stem cells (hASCs) in vitro and in vivo.	calcium phosphate	43-60	bone morphogenetic protein 2	Homo sapiens	121-126
27811847-2	2017	We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability.	calcium phosphate	98-115	synuclein alpha	Homo sapiens	117-121
28128919-1	2017	Hydroxyapatite (Ca10 (PO4)6(OH)2, HAP), a multimineral substituted calcium phosphate is one of the most substantial bone mineral component that has been widely used as bone replacement materials because of its bioactive and biocompatible properties.	calcium phosphate	67-84	carbonic anhydrase 10	Homo sapiens	16-20
28326227-0	2017	Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles.	calcium phosphate	60-77	HtrA serine peptidase 2	Homo sapiens	33-38
27977128-3	2016	Here, we constructed a PEG/Lipids/calcium phosphate (CaP)-OncoAd (PLC-OncoAd) delivery system for ZD55-IL-24, an oncolytic adenovirus that carries the IL-24 gene.	calcium phosphate	34-51	interleukin 24	Mus musculus	103-108
27520723-0	2017	Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors.	calcium phosphate	0-17	microRNA 221	Homo sapiens	134-141
27520723-1	2017	In this study, a development of a novel calcium phosphate-polymer hybrid nanoparticle system is reported.The nanoparticle system can co-encapsulate and co-deliver a combination of therapeutic agents with different physicochemical properties (i.e., inhibitors for microRNA-221 and microRNA-222 (miRi-221/222) and paclitaxel (pac)).miRi-221/222 are hydrophilic and were encapsulated with calcium phosphate by co-precipitation in a water-in-oil emulsion.The precipitates were then coated with an anionic lipid, dioleoylphosphatidic acid (DOPA), to co-encapsulate hydrophobic paclitaxel outside the hydrophilic precipitates and inside the same nanoparticle.The nanoparticles formed by following this approach had a size of about <=100nm and contained both lipid-coated calcium phosphate/miRi and paclitaxel.This nanoparticle system was found to simultaneously deliver paclitaxel and miRi-221/222 to their intracellular targets, leading to inhibit proliferative mechanisms of miR-221/222 and thus significantly enhancing the therapeutic efficacy of paclitaxel.	calcium phosphate	40-57	microRNA 221	Homo sapiens	974-981
27863995-2	2017	We have previously developed a potent mannose-modified lipid calcium phosphate (LCP) nanoparticle (NP)-based Trp2 vaccine for melanoma therapy, but because this vaccine can induce a potent anti-tumor immune response only during the early stages of melanoma, poor tumor growth inhibition has been observed in more advanced melanoma models, likely due to the development of an immune-suppressive tumor microenvironment (TME).	calcium phosphate	61-78	tRNA proline 2	Mus musculus	109-113
28269742-1	2017	BACKGROUND: In our earlier work, tobermorite containing calcium phosphate (CP) clusters (CP-Tob) was hydrothermally prepared in the CaO-SiO2-P2O5-H2O system for biomedical applications.	calcium phosphate	56-73	transducer of ERBB2, 1	Homo sapiens	92-95
28572822-2	2017	Salivary proteins such as statherin inhibit crystal growth of calcium phosphate in supersaturated solutions and interact with several oral bacteria to adsorb on hydroxyapatite.	calcium phosphate	62-79	statherin	Homo sapiens	26-35
27138291-7	2017	Cells seeded in a calcium-phosphate coated plate or bone slices showed reduced resorption area when exposed to milk P100 during the differentiation phase and even after osteoclast formation.	calcium phosphate	18-35	Weaning weight-maternal milk	Bos taurus	111-115
28840128-6	2017	However, calcium phosphate (CaP; mg2/dL2) product was positively associated with the presence of carotid plaques (ORadj = 1.078; 95% CI: 1.017-1.142).	calcium phosphate	9-26	l(1)L2	Drosophila melanogaster	37-40
28840128-6	2017	However, calcium phosphate (CaP; mg2/dL2) product was positively associated with the presence of carotid plaques (ORadj = 1.078; 95% CI: 1.017-1.142).	calcium phosphate	28-31	l(1)L2	Drosophila melanogaster	37-40
27794235-1	2017	Cellulose grafted with soy protein isolate (SPI), sustainable and cost effective material, was investigated as a bioactive material for calcium phosphate mineralization.	calcium phosphate	136-153	chromogranin A	Homo sapiens	44-47
28139726-0	2017	BMP2-coprecipitated calcium phosphate granules enhance osteoinductivity of deproteinized bovine bone, and bone formation during critical-sized bone defect healing.	calcium phosphate	20-37	bone morphogenetic protein 2	Bos taurus	0-4
28139726-2	2017	The effect of bone morphogenic protein 2 (BMP2)-coprecipitated biomimetic calcium phosphate granules (BMP2-cop.BioCaP) on osteoinduction of DBB graft(s) during CSBD healing is still unknown.	calcium phosphate	74-91	bone morphogenetic protein 2	Bos taurus	14-40
28139726-2	2017	The effect of bone morphogenic protein 2 (BMP2)-coprecipitated biomimetic calcium phosphate granules (BMP2-cop.BioCaP) on osteoinduction of DBB graft(s) during CSBD healing is still unknown.	calcium phosphate	74-91	bone morphogenetic protein 2	Bos taurus	42-46
28139726-2	2017	The effect of bone morphogenic protein 2 (BMP2)-coprecipitated biomimetic calcium phosphate granules (BMP2-cop.BioCaP) on osteoinduction of DBB graft(s) during CSBD healing is still unknown.	calcium phosphate	74-91	bone morphogenetic protein 2	Bos taurus	102-106
27960182-0	2017	Calcium-Phosphate-Osteopontin Particles Reduce Biofilm Formation and pH Drops in in situ Grown Dental Biofilms.	calcium phosphate	0-17	secreted phosphoprotein 1	Bos taurus	18-29
27960182-4	2017	Here, smooth surface biofilms from 10 individuals were treated ex vivo 6 times/day for 30 min with either calcium-phosphate-osteopontin particles or sterile saline.	calcium phosphate	106-123	secreted phosphoprotein 1	Bos taurus	124-135
27883077-9	2016	SEM and TEM analysis showed that TRIP-1 promoted the nucleation and growth of calcium phosphate mineral aggregates.	calcium phosphate	78-95	peptidase B	Mus musculus	33-39
26510170-0	2016	Addition of a Synthetically Fabricated Osteoinductive Biphasic Calcium Phosphate Bone Graft to BMP2 Improves New Bone Formation.	calcium phosphate	63-80	bone morphogenetic protein 2	Rattus norvegicus	95-99
26510170-3	2016	PURPOSE: The aim of the present study was to assess whether the combination of BMP2 with this novel Biphasic Calcium Phosphate (BCP) scaffold may additionally promote new bone regeneration.	calcium phosphate	109-126	bone morphogenetic protein 2	Rattus norvegicus	79-83
29693998-9	2017	The discovery of theprotein klotho led to the identificationof new axes connecting endocrinedisturbances in the homeostasis ofthe calcium-phosphate to the aging ofthe organism.	calcium phosphate	130-147	klotho	Mus musculus	28-34
28001239-1	2016	Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus.	calcium phosphate	34-51	alpha 2-HS glycoprotein	Homo sapiens	0-8
27558264-1	2016	Recent studies have shown that native phosphorylated full-length porcine amelogenin (P173) and its predominant cleavage product (P148) can inhibit spontaneous calcium phosphate formation in vitro by stabilizing an amorphous calcium phosphate (ACP) precursor phase.	calcium phosphate	159-176	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	85-89
27558264-1	2016	Recent studies have shown that native phosphorylated full-length porcine amelogenin (P173) and its predominant cleavage product (P148) can inhibit spontaneous calcium phosphate formation in vitro by stabilizing an amorphous calcium phosphate (ACP) precursor phase.	calcium phosphate	224-241	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	85-89
27899269-2	2016	PTH plays a central role in regulating calcium phosphate metabolism and its increases in production in response to low serum calcium levels.	calcium phosphate	39-56	parathyroid hormone	Rattus norvegicus	0-3
28774075-0	2016	Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration.	calcium phosphate	29-46	bone morphogenetic protein 2	Homo sapiens	11-16
25675839-1	2016	OBJECTIVES: This study compared the bone regenerative effects of a recombinant human bone morphogenetic protein 2 (rhBMP-2)-loaded collagen-based biphasic calcium phosphate composite (BCPC) and rhBMP-2-loaded biphasic calcium phosphate (BCP).	calcium phosphate	155-172	bone morphogenetic protein 2	Homo sapiens	85-113
27714043-4	2016	A common biochemical feature of both fetuin A and osteopontin is their inhibiting role in calcium phosphate precipitation.	calcium phosphate	90-107	alpha 2-HS glycoprotein	Homo sapiens	37-45
27714043-4	2016	A common biochemical feature of both fetuin A and osteopontin is their inhibiting role in calcium phosphate precipitation.	calcium phosphate	90-107	secreted phosphoprotein 1	Homo sapiens	50-61
27714043-6	2016	Quantitative analyses of calcium, phosphorus and uranium performed using inductively coupled plasma/mass spectrometry (ICP/MS) demonstrated the inhibition of the precipitation of calcium phosphate by fetuin A and osteopontin for 2 h.	calcium phosphate	179-196	alpha 2-HS glycoprotein	Homo sapiens	200-232
27831902-6	2016	To address this challenge, we developed a lipid calcium phosphate nanoparticle optimized for delivering plasmid DNA, encoding an engineered CXCL12 protein trap, to the nucleus of liver hepatocytes.	calcium phosphate	48-65	C-X-C motif chemokine ligand 12	Homo sapiens	140-146
27711142-0	2016	A Study of BMP-2-Loaded Bipotential Electrolytic Complex around a Biphasic Calcium Phosphate-Derived (BCP) Scaffold for Repair of Large Segmental Bone Defect.	calcium phosphate	75-92	bone morphogenetic protein 2	Oryctolagus cuniculus	11-16
27702654-8	2016	In BMP2-induced type 2 diabetic BMSCs with calcium phosphate cement (CPC) scaffolds for osteoblast study in vivo, the appearance of newly formed bone dramatically increased to 175% compared with type 2 diabetic BMSCs.	calcium phosphate	43-60	bone morphogenetic protein 2	Rattus norvegicus	3-7
29638072-7	2016	It was found that LS2 tablets containing spherically granulated dibasic calcium phosphate and magnesium aluminometasilicate exhibit the best dissolution profile and mechanical properties while tablets composed only with Neusilin  US2 was characterized by the smallest size and mass with preserved good mechanical properties and furosemide dissolution.	calcium phosphate	72-89	serpin family D member 1	Homo sapiens	18-21
27800217-0	2016	Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus.	calcium phosphate	124-141	bone morphogenetic protein 2	Oryctolagus cuniculus	74-102
27442254-3	2016	Microscopic examination of the kidneys of pendrin/NCC-dKO mice revealed the presence of calcium phosphate deposits in the medullary collecting ducts, along with increased urinary calcium and phosphate excretion.	calcium phosphate	88-105	solute carrier family 26, member 4	Mus musculus	42-49
27156155-0	2016	Magnesium modification up-regulates the bioactivity of bone morphogenetic protein-2 upon calcium phosphate cement via enhanced BMP receptor recognition and Smad signaling pathway.	calcium phosphate	89-106	bone morphogenetic protein 2	Homo sapiens	55-83
26790377-7	2016	The defect, which is closed with a porous membrane, is filled with fragments of synovial tissue, as a source of meniscoprogenitor cells, and a fibrin-embedded, calcium-phosphate-entrapped depot of the meniscogenic agents BMP-2 and TGF-beta1.	calcium phosphate	160-177	bone morphogenetic protein 2	Homo sapiens	221-226
27327110-1	2016	OBJECTIVES: We recently developed a new rechargeable composite with nanoparticles of amorphous calcium phosphate (NACP) having long-term calcium (Ca) and phosphate (P) ion release; however, this composite was not antibacterial.	calcium phosphate	95-112	synuclein alpha	Homo sapiens	114-118
27471382-4	2016	In this study, poly(ethylene glycol) (PEG)-stabilized amorphous calcium phosphate (ACP) nanoparticles were prepared by wet-chemical method and then loaded with recombinant human CEMP1 (rhCEMP1) for controlled release.	calcium phosphate	64-81	CPAT1	Homo sapiens	83-86
27228365-3	2016	RECENT FINDINGS: Calcium and phosphate combine with calcification-inhibiting proteins, mainly fetuin-A, to form amorphous calcium phosphate-containing primary calciprotein particles (CPPs).	calcium phosphate	122-139	alpha 2-HS glycoprotein	Homo sapiens	94-102
27471382-4	2016	In this study, poly(ethylene glycol) (PEG)-stabilized amorphous calcium phosphate (ACP) nanoparticles were prepared by wet-chemical method and then loaded with recombinant human CEMP1 (rhCEMP1) for controlled release.	calcium phosphate	64-81	cementum protein 1	Homo sapiens	178-183
26780236-4	2016	We have applied these and complementary techniques to search for nanocrystals within clusters of calcium phosphate sequestered by bovine phosphopeptides, derived from osteopontin or casein.	calcium phosphate	97-114	secreted phosphoprotein 1	Bos taurus	167-178
27015737-0	2016	Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury.	calcium phosphate	40-57	neurotrophin 3	Rattus norvegicus	21-35
27015737-2	2016	This study uses peripheral nerve grafts (PNGs) as scaffolds for axonal growth while delivering neurotrophin-3 (NT-3) via calcium phosphate (CaP) coatings on surgical sutures.	calcium phosphate	121-138	neurotrophin 3	Rattus norvegicus	95-109
27015737-2	2016	This study uses peripheral nerve grafts (PNGs) as scaffolds for axonal growth while delivering neurotrophin-3 (NT-3) via calcium phosphate (CaP) coatings on surgical sutures.	calcium phosphate	121-138	neurotrophin 3	Rattus norvegicus	111-115
26714212-4	2016	MGP is a vitamin K-dependent protein that ordinarily prevents systemic calcification by scavenging calcium phosphate in the tissues.	calcium phosphate	99-116	matrix Gla protein	Homo sapiens	0-3
27340350-2	2016	METHODS: An expression vector carrying fusion suicide gene (yCDglyTK) and shRNA against vascular endothelial growth factor (VEGF) was constructed and delivered into EC9706 esophageal cancer cells by calcium phosphate nanoparticles (CPNP).	calcium phosphate	199-216	vascular endothelial growth factor A	Homo sapiens	124-128
27353337-2	2016	In this work, microporous TiO2/calcium-phosphate coating on Ti doped with strontium, cobalt and fluorine (SCF-TiCP) was developed, which had a hierarchical micro/nano-structure with a microporous structure evenly covered with nano-grains.	calcium phosphate	31-48	KIT ligand	Rattus norvegicus	106-109
26966276-12	2016	The B2R antagonist (B9330; 5 mug) delivered directly to the aortic wall 1 week post-AAA induction with calcium phosphate in a rat model reduced aneurysm growth associated with downregulation of aortic metalloproteinase-9.	calcium phosphate	103-120	bradykinin receptor B2	Rattus norvegicus	4-7
28959745-3	2016	Therefore, if a product such as casein phospho peptides - amorphous calcium phosphate (CPP- ACP) which can significantly increase the availability of calcium and phosphate in the plaque and saliva should have an anti-caries protective effect.	calcium phosphate	68-85	CPAT1	Homo sapiens	92-95
27055909-0	2016	The association of the Klotho polymorphism rs9536314 with parameters of calcium-phosphate metabolism in patients on long-term hemodialysis.	calcium phosphate	72-89	klotho	Homo sapiens	23-29
27305825-0	2016	Stimulation of Odontogenesis and Angiogenesis via Bioactive Nanocomposite Calcium Phosphate Cements Through Integrin and VEGF Signaling Pathways.	calcium phosphate	74-91	vascular endothelial growth factor A	Homo sapiens	121-125
27025265-1	2016	Composites containing nanoparticles of amorphous calcium phosphate (NACP) remineralize tooth lesions and inhibit caries.	calcium phosphate	49-66	synuclein alpha	Homo sapiens	68-72
27389239-0	2016	Regulatory inhibition of biological tissue mineralization by calcium phosphate through post-nucleation shielding by fetuin-A.	calcium phosphate	61-78	alpha 2-HS glycoprotein	Homo sapiens	116-124
26743970-3	2016	The objectives of this study were to develop rechargeable CaP dental composite for the first time, and investigate the Ca and P recharge and re-release of composites with nanoparticles of amorphous calcium phosphate (NACP) to achieve long-term inhibition of caries.	calcium phosphate	198-215	synuclein alpha	Homo sapiens	217-221
27004288-0	2016	A 3-Year Prospective Cohort Study on 132 Calcium Phosphate-Blasted Implants: Flap vs Flapless Technique.	calcium phosphate	41-58	arachidonate 5-lipoxygenase activating protein	Homo sapiens	77-81
26980656-1	2016	OBJECTIVE: To evaluate the effect of 2-methacryloyloxyethyl phosphorylcholine (MPC) and nanoparticles of amorphous calcium phosphate (NACP) on the protein-repellent property of dental adhesive.	calcium phosphate	115-132	synuclein alpha	Homo sapiens	134-138
26685755-0	2016	Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin.	calcium phosphate	42-59	insulin	Homo sapiens	146-153
26685755-1	2016	UNLABELLED: The present study investigates the potential of layer by layer coated calcium phosphate nanoparticles - for oral delivery of insulin where Vitamin B12 grafted chitosan and sodium alginate have been used as cationic and anionic polyelectrolyte respectively.	calcium phosphate	82-99	insulin	Homo sapiens	137-144
26706534-2	2016	We generated a novel calcium phosphate (CPC) composite scaffold, which contains BMP-VEGF-loaded poly-lactic-co-glycolic acid (PLGA) microspheres (BMP-VEGF-PLGA-CPC).	calcium phosphate	21-38	vascular endothelial growth factor A	Oryctolagus cuniculus	84-88
26606286-1	2016	PURPOSE: The aim of this study was to characterize the healing in rabbit calvarial bone defects after delivery of limited-dose (1.5 mug) Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), and evaluate biphasic calcium phosphate (BCP) as a carrier.	calcium phosphate	243-260	bone morphogenetic protein 2	Homo sapiens	180-208
23897753-9	2016	Expression of osteogenic markers osteopontin, alkaline phosphatase (ALP), osteocalcin and type 1 collagen increased gradually with calcium phosphate deposition on GLU-NF microsheets.	calcium phosphate	131-148	bone gamma-carboxyglutamate protein	Rattus norvegicus	74-85
26667613-3	2016	Hydroxyapatite particle (HAp) composed of calcium phosphate has been shown to work as adjuvant in mice.	calcium phosphate	42-59	retinoic acid receptor, beta	Mus musculus	25-28
27200151-3	2016	However, mutation in SLC34A2 gene that encodes a sodium phosphate co-transporter in alveolar type-II cells resulting in formation and accumulation of microliths rich in calcium phosphate due to impaired clearance is considered the cause of disease.	calcium phosphate	169-186	solute carrier family 34 member 2	Homo sapiens	21-28
26652387-4	2016	The effects of CEMP1 concentrations (0-100mug/ml) on the rate of calcium phosphate precipitation was monitored during 48h, while the formed mineral phases were assessed utilizing transmission electron microscope (TEM), selected area electron diffraction (SAED), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR).	calcium phosphate	65-82	cementum protein 1	Homo sapiens	15-20
27405261-5	2016	Incorporation of ALP in hydrogels followed by incubation in a solution containing calcium ions and glycerophosphate, a substrate for ALP, led to formation of calcium phosphate within the hydrogel.	calcium phosphate	158-175	alkaline phosphatase, placental	Homo sapiens	17-20
27405261-5	2016	Incorporation of ALP in hydrogels followed by incubation in a solution containing calcium ions and glycerophosphate, a substrate for ALP, led to formation of calcium phosphate within the hydrogel.	calcium phosphate	158-175	alkaline phosphatase, placental	Homo sapiens	133-136
28097158-4	2016	This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules.	calcium phosphate	309-326	secreted phosphoprotein 1	Homo sapiens	44-47
26204506-7	2016	The introduction of SrO increases the solubility for both glasses and glass ceramics and this is assumed to be due to the formation of Sr phosphate which is more soluble than calcium phosphate (hydroxyapatite).	calcium phosphate	175-192	stomatin like 3	Homo sapiens	20-23
26923119-0	2016	Calcium-phosphate-osteopontin particles for caries control.	calcium phosphate	0-17	secreted phosphoprotein 1	Homo sapiens	18-29
26923119-8	2016	Hence, calcium-phosphate-osteopontin particles show potential for applications in caries control.	calcium phosphate	7-24	secreted phosphoprotein 1	Homo sapiens	25-36
26386269-2	2016	In this study, we evaluated the release kinetics and delivery efficacies of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, incorporated into calcium phosphate bone grafts (BGs).	calcium phosphate	172-189	vascular endothelial growth factor A	Rattus norvegicus	76-110
26386269-2	2016	In this study, we evaluated the release kinetics and delivery efficacies of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, incorporated into calcium phosphate bone grafts (BGs).	calcium phosphate	172-189	vascular endothelial growth factor A	Rattus norvegicus	112-116
24673932-0	2015	Acceleration of Bone Regeneration by BMP-2-Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus.	calcium phosphate	72-89	bone morphogenetic protein 2	Oryctolagus cuniculus	37-42
26478017-0	2015	Amifostine-conjugated pH-sensitive calcium phosphate-covered magnetic-amphiphilic gelatin nanoparticles for controlled intracellular dual drug release for dual-targeting in HER-2-overexpressing breast cancer.	calcium phosphate	35-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	173-178
26689714-6	2015	RESULTS: The expression of collagen type I and osteocalcin genes of BMSCs or BMSC sheets treated with PRP and calcium phosphate particles was significantly higher than that of BMSCs or BMSC sheets treated with calcium phosphate particles or the controls (P <0.05).	calcium phosphate	210-227	proline rich protein 2-like 1	Rattus norvegicus	102-105
26689714-10	2015	At 4 weeks after implantation, the defects treated with the BMSC sheet/PRP gel/calcium phosphate particles showed significantly more bone formation than the other five groups.	calcium phosphate	79-96	proline rich protein 2-like 1	Rattus norvegicus	71-74
26689714-11	2015	CONCLUSIONS: Incorporation of an BMSC sheet into the PRP gel/calcium phosphate particles greatly promoted bone regeneration.	calcium phosphate	61-78	proline rich protein 2-like 1	Rattus norvegicus	53-56
26885257-0	2015	Sustained release poly (lactic-co-glycolic acid) microspheres of bone morphogenetic protein 2 plasmid/calcium phosphate to promote in vitro bone formation and in vivo ectopic osteogenesis.	calcium phosphate	102-119	bone morphogenetic protein 2	Homo sapiens	65-93
26885257-2	2015	In the present study, calcium phosphate (CaPi) was used to promote transfection of human bone morphogenetic protein 2 (BMP-2) cDNA plasmid, and poly (lactic-co-glycolic acid) (PLGA) was used to prepare microspheres of pBMP-2/CaPi (i.e., PLGA@pBMP-2/CaPi) using W/O/W double emulsion solvent evaporation method.	calcium phosphate	22-39	bone morphogenetic protein 2	Homo sapiens	89-117
26885257-2	2015	In the present study, calcium phosphate (CaPi) was used to promote transfection of human bone morphogenetic protein 2 (BMP-2) cDNA plasmid, and poly (lactic-co-glycolic acid) (PLGA) was used to prepare microspheres of pBMP-2/CaPi (i.e., PLGA@pBMP-2/CaPi) using W/O/W double emulsion solvent evaporation method.	calcium phosphate	22-39	bone morphogenetic protein 2	Homo sapiens	119-124
24673932-1	2015	PURPOSE: The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus.	calcium phosphate	97-114	bone morphogenetic protein 2	Oryctolagus cuniculus	139-167
24673932-1	2015	PURPOSE: The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus.	calcium phosphate	97-114	bone morphogenetic protein 2	Oryctolagus cuniculus	169-174
26097146-0	2015	Calcium phosphate nanoparticles carrying BMP-7 plasmid DNA induce an osteogenic response in MC3T3-E1 pre-osteoblasts.	calcium phosphate	0-17	bone morphogenetic protein 7	Mus musculus	41-46
26404407-2	2015	Previous studies synthesized nanoparticles of amorphous calcium phosphate (NACP) and dimethylaminohexadecyl methacrylate (DMAHDM).	calcium phosphate	56-73	synuclein alpha	Homo sapiens	75-79
26230465-0	2015	Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement.	calcium phosphate	106-123	colony stimulating factor 2	Homo sapiens	8-11
26331695-5	2015	Teriparatide (recombinant parathyroid hormone) injections were initiated (up to three times daily) with improvement in the vascular changes and a decrease in calcium phosphate calcification in biopsy, as well as reduction in hypercalciuria, restoration of calcium phosphate homeostasis and stabilization of allograft function.	calcium phosphate	158-175	parathyroid hormone	Homo sapiens	26-45
26144190-4	2015	METHODS: Nanoparticles of amorphous calcium phosphate (NACP) were synthesized.	calcium phosphate	36-53	synuclein alpha	Homo sapiens	55-59
26180236-8	2015	LPD decreased the serum fetuin-A level and fetuin-A synthesis in the liver and increased serum calcium-phosphate precipitates.	calcium phosphate	95-112	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	0-3
26361810-2	2015	This randomized, controlled, single-blind crossover study evaluated the effectiveness of a calcium phosphate containing desensitizer paste (TAP) on DH in comparison to water as placebo (PLA).	calcium phosphate	91-108	nuclear RNA export factor 1	Homo sapiens	140-143
26997697-0	2015	Comparison of Calcium Phosphate and Zinc Oxide Nanoparticles as Dermal Penetration Enhancers for Albumin.	calcium phosphate	14-31	albumin	Mus musculus	97-104
26997697-3	2015	Since dermal delivery of proteins encounter problems, in this investigation, zinc oxide nanoparticles and calcium phosphate nanoparticles were compared as enhancers for dermal permeation of albumin.	calcium phosphate	106-123	albumin	Mus musculus	190-197
26997697-7	2015	Zinc oxide nanoparticles and calcium phosphate nanoparticles acted as enhancers for skin permeation of albumin.	calcium phosphate	29-46	albumin	Mus musculus	103-110
26997697-10	2015	After 0.5 or 1 h, the permeated albumin in presence of calcium phosphate nanoparticles was more than that in presence of zinc oxide nanoparticles and after 1.5 h the permeated albumin in presence of zinc oxide nanoparticles was more than that in presence of calcium phosphate nanoparticles.	calcium phosphate	55-72	albumin	Mus musculus	32-39
26997697-10	2015	After 0.5 or 1 h, the permeated albumin in presence of calcium phosphate nanoparticles was more than that in presence of zinc oxide nanoparticles and after 1.5 h the permeated albumin in presence of zinc oxide nanoparticles was more than that in presence of calcium phosphate nanoparticles.	calcium phosphate	55-72	albumin	Mus musculus	176-183
26997697-10	2015	After 0.5 or 1 h, the permeated albumin in presence of calcium phosphate nanoparticles was more than that in presence of zinc oxide nanoparticles and after 1.5 h the permeated albumin in presence of zinc oxide nanoparticles was more than that in presence of calcium phosphate nanoparticles.	calcium phosphate	258-275	albumin	Mus musculus	32-39
26997697-10	2015	After 0.5 or 1 h, the permeated albumin in presence of calcium phosphate nanoparticles was more than that in presence of zinc oxide nanoparticles and after 1.5 h the permeated albumin in presence of zinc oxide nanoparticles was more than that in presence of calcium phosphate nanoparticles.	calcium phosphate	258-275	albumin	Mus musculus	176-183
26997697-14	2015	Maximum cumulative (total) permeated albumin in presence of zinc oxide nanoparticles was obtained at time of 1.5 h, which was 40.2+-3.6 mg, while in presence of calcium phosphate nanoparticles, it was obtained at 1 h, which was 33.8+-5.5 mg.	calcium phosphate	161-178	albumin	Mus musculus	37-44
33210899-0	2015	Comparison of Calcium Phosphate and Zinc Oxide Nanoparticles as Dermal Penetration Enhancers for Albumin.	calcium phosphate	14-31	albumin	Homo sapiens	97-104
26516841-8	2015	Our results demonstrated that the administration of IFN-gamma and Zol enhanced bone regeneration of alpha-TCP/CS implants by enhancing bone formation, while hampering excess bone resorption.	calcium phosphate	100-109	interferon gamma	Rattus norvegicus	52-61
26180236-10	2015	Reduced fetal calf serum in the medium of cultured vascular smooth muscle cells enhanced phosphate-induced formation of calcium-phosphate precipitates in the media and calcification of vascular smooth muscle cells, both of which were prevented by fetuin-A administration.	calcium phosphate	120-137	alpha-2-HS-glycoprotein	Rattus norvegicus	247-255
24888232-0	2015	Enhanced bone healing by improved fibrin-clot formation via fibrinogen adsorption on biphasic calcium phosphate granules.	calcium phosphate	94-111	fibrinogen beta chain	Homo sapiens	60-70
26504384-3	2015	Lactoferrin (Lf) is a natural milk protein, which has shown antimicrobial properties in its nanoformulation using alginate chitosan calcium phosphate bovine lactoferrin nanocapsules (AEC-CCo-CP-bLf-NCs).	calcium phosphate	132-149	lactotransferrin	Bos taurus	0-11
26504384-3	2015	Lactoferrin (Lf) is a natural milk protein, which has shown antimicrobial properties in its nanoformulation using alginate chitosan calcium phosphate bovine lactoferrin nanocapsules (AEC-CCo-CP-bLf-NCs).	calcium phosphate	132-149	lactotransferrin	Bos taurus	13-15
24888232-2	2015	This study aimed at improving the fibrin-clotting rate by coating the surface of biphasic calcium phosphate (BCP) granules with fibrinogen (FNG).	calcium phosphate	90-107	fibrinogen beta chain	Homo sapiens	128-138
24888232-2	2015	This study aimed at improving the fibrin-clotting rate by coating the surface of biphasic calcium phosphate (BCP) granules with fibrinogen (FNG).	calcium phosphate	90-107	fibrinogen beta chain	Homo sapiens	140-143
26389017-5	2015	The aim of our study was to evaluate whether calcium phosphate metabolism disorders and their clinical complications are differently distributed among DD patients with and without CLCN5 mutations.	calcium phosphate	45-62	chloride voltage-gated channel 5	Homo sapiens	180-185
32262825-0	2015	Gene silencing of the pro-inflammatory cytokine TNF-alpha with siRNA delivered by calcium phosphate nanoparticles, quantified by different methods.	calcium phosphate	82-99	tumor necrosis factor	Mus musculus	48-57
32262825-1	2015	The pro-inflammatory cytokine TNF-alpha was silenced by treating MODE-K cells with triple-shell calcium phosphate nanoparticles.	calcium phosphate	96-113	tumor necrosis factor	Mus musculus	30-39
32262825-7	2015	Thus, calcium phosphate nanoparticles are well suited to reduce inflammatory reactions by silencing the corresponding cytokines, e.g. TNF-alpha.	calcium phosphate	6-23	tumor necrosis factor	Mus musculus	134-143
25819092-5	2015	The Ca-phosphate (P)-parathyroid hormone (PTH) profile includes creatinine, urea, total and ionized Ca, albumin, sodium, potassium, P, PTH levels at start, mid, and end of dialysis.	calcium phosphate	4-16	parathyroid hormone	Homo sapiens	42-45
26354827-2	2015	The unfolded state of osteopontin (OPN) is thought to be a prerequisite for this activity, which leads to the formation of core-shell calcium phosphate nanoclusters.	calcium phosphate	134-151	secreted phosphoprotein 1	Bos taurus	22-33
26354827-2	2015	The unfolded state of osteopontin (OPN) is thought to be a prerequisite for this activity, which leads to the formation of core-shell calcium phosphate nanoclusters.	calcium phosphate	134-151	secreted phosphoprotein 1	Bos taurus	35-38
26100670-3	2015	However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy.	calcium phosphate	46-50	zinc fingers and homeoboxes 2	Homo sapiens	9-12
26100670-3	2015	However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy.	calcium phosphate	46-50	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	70-75
26100670-3	2015	However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy.	calcium phosphate	46-50	zinc fingers and homeoboxes 2	Homo sapiens	72-75
26394359-0	2015	Application of a Collagenated Biphasic Calcium Phosphate Loaded with Fibroblast Growth Factor-2 in the Rabbit Sinus: A Pilot Study.	calcium phosphate	39-56	fibroblast growth factor 2	Oryctolagus cuniculus	69-95
25319519-0	2015	Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism.	calcium phosphate	84-101	checkpoint kinase 2	Mus musculus	18-22
25709009-0	2015	Bone formation of a porous Gelatin-Pectin-biphasic calcium phosphate composite in presence of BMP-2 and VEGF.	calcium phosphate	51-68	bone morphogenetic protein 2	Rattus norvegicus	94-99
26300955-0	2015	Surgical results with the use of Silicated Calcium Phosphate (SiCaP) as bone graft substitute in Posterior Spinal Fusion (PSF) for Adolescent Idiopathic Scoliosis (AIS).	calcium phosphate	43-60	IS1	Homo sapiens	131-162
26098135-2	2015	Inspired by mussels, biomimetic calcium phosphate apatite/polydopamine hybridized-polyethylene terephthalate (APA/PDA-PET) grafts were successfully prepared.	calcium phosphate	32-49	glutamyl aminopeptidase	Homo sapiens	110-121
25987986-3	2015	In the past decade, through in vitro, in vivo and clinical observation studies, we have come to appreciate the importance of fetuin-A (Fet-A), a circulating glycoprotein, in preventing ectopic calcium phosphate mineralisation.	calcium phosphate	193-210	alpha 2-HS glycoprotein	Homo sapiens	125-133
25831148-2	2015	Combined delivery of anti-miR-21 and anti-miR-95 by calcium phosphate nanoparticles significantly inhibited tumor growth in a xenograft tumor model and sensitized radiotherapy.	calcium phosphate	52-69	microRNA 21	Homo sapiens	26-32
25831148-2	2015	Combined delivery of anti-miR-21 and anti-miR-95 by calcium phosphate nanoparticles significantly inhibited tumor growth in a xenograft tumor model and sensitized radiotherapy.	calcium phosphate	52-69	microRNA 95	Homo sapiens	42-48
25466354-2	2015	Two calcium phosphate proteins, statherin (43 amino acids) and leucine rich amelogenin protein (LRAP; 59 amino acids), have been studied in depth and have different dynamic properties and 2D- and 3D-structural features.	calcium phosphate	4-21	statherin	Homo sapiens	32-41
26179165-0	2015	Benefits of biphasic calcium phosphate hybrid scaffold-driven osteogenic differentiation of mesenchymal stem cells through upregulated leptin receptor expression.	calcium phosphate	21-38	leptin receptor	Oryctolagus cuniculus	135-150
25808925-0	2015	Effect of Local Sustainable Release of BMP2-VEGF from Nano-Cellulose Loaded in Sponge Biphasic Calcium Phosphate on Bone Regeneration.	calcium phosphate	95-112	bone morphogenetic protein 2	Rattus norvegicus	39-43
25808925-0	2015	Effect of Local Sustainable Release of BMP2-VEGF from Nano-Cellulose Loaded in Sponge Biphasic Calcium Phosphate on Bone Regeneration.	calcium phosphate	95-112	vascular endothelial growth factor A	Rattus norvegicus	44-48
25808925-4	2015	A biphasic calcium phosphate (BCP)-NC-BMP2-VEGF (BNBV) scaffold was fabricated for this purpose.	calcium phosphate	11-28	bone morphogenetic protein 2	Rattus norvegicus	38-42
25808925-4	2015	A biphasic calcium phosphate (BCP)-NC-BMP2-VEGF (BNBV) scaffold was fabricated for this purpose.	calcium phosphate	11-28	vascular endothelial growth factor A	Rattus norvegicus	43-47
25709009-0	2015	Bone formation of a porous Gelatin-Pectin-biphasic calcium phosphate composite in presence of BMP-2 and VEGF.	calcium phosphate	51-68	vascular endothelial growth factor A	Rattus norvegicus	104-108
25641804-1	2015	One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP).	calcium phosphate	109-126	phosphoglycolate phosphatase	Homo sapiens	84-87
25641804-1	2015	One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP).	calcium phosphate	109-126	BCL2 apoptosis regulator	Homo sapiens	92-97
25687004-0	2015	Calcium phosphate coated Keratin-PCL scaffolds for potential bone tissue regeneration.	calcium phosphate	0-17	PHD finger protein 1	Homo sapiens	33-36
25100662-0	2015	BMP-2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration.	calcium phosphate	65-82	bone morphogenetic protein 2	Oryctolagus cuniculus	0-5
25100662-1	2015	Bone morphology protein-2 (BMP-2) encapsulated chitosan/chondrotin sulfate nanoparticles (CHI/CS NPs) are developed to enhance ectopic bone formation on biphasic calcium phosphate (BCP) scaffolds.	calcium phosphate	162-179	bone morphogenetic protein 2	Oryctolagus cuniculus	27-32
25687004-3	2015	In this work, a new method was developed to achieve a uniform coating of calcium phosphate (CaP) onto electrospun keratin-polycaprolactone composites (Keratin-PCL).	calcium phosphate	73-90	PHD finger protein 1	Homo sapiens	159-162
25893016-3	2015	The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation.	calcium phosphate	15-32	bone morphogenetic protein 2	Homo sapiens	89-94
25861317-7	2015	Eight SECs specific to hTERT were designed by overlap extension polymerase chain reaction (PCR) and transfected into HepG2 cells with calcium phosphate.	calcium phosphate	134-151	telomerase reverse transcriptase	Homo sapiens	23-28
25852562-3	2015	While its hierarchical structure is unrivaled in its mechanical resilience, heterogeneity in the distribution of magnesium ions and the presence of Mg-substituted amorphous calcium phosphate (Mg-ACP) as an intergranular phase have recently been shown to increase the susceptibility of mouse enamel to acid attack.	calcium phosphate	173-190	vitamin A enhanced cleft palate	Mus musculus	195-198
25542535-0	2015	In situ DOX-calcium phosphate mineralized CPT-amphiphilic gelatin nanoparticle for intracellular controlled sequential release of multiple drugs.	calcium phosphate	12-29	choline phosphotransferase 1	Homo sapiens	42-45
25723095-4	2015	Nanoparticles of amorphous calcium phosphate (NACP) released calcium/phosphate ions, remineralized tooth-lesions and neutralized acids.	calcium phosphate	27-44	synuclein alpha	Homo sapiens	46-50
26436096-0	2015	The Effect of Covalently Immobilized FGF-2 on Biphasic Calcium Phosphate Bone Substitute on Enhanced Biological Compatibility and Activity.	calcium phosphate	55-72	fibroblast growth factor 2	Homo sapiens	37-42
25462843-4	2015	Analytical, biochemical and immunohistochemical characterization show that ALP is efficiently immobilized, retains its activity and can trigger calcium phosphate mineralization on alumina at acellular conditions.	calcium phosphate	144-161	alkaline phosphatase, placental	Homo sapiens	75-78
25514036-5	2015	The IL-10-producing induced osteoblast-like cells (IL-10-iOBs) strongly expressed osteoblast-specific genes and massively produced bone matrix that were mineralized by calcium phosphate in vitro and in vivo.	calcium phosphate	168-185	interleukin 10	Mus musculus	4-9
25514036-5	2015	The IL-10-producing induced osteoblast-like cells (IL-10-iOBs) strongly expressed osteoblast-specific genes and massively produced bone matrix that were mineralized by calcium phosphate in vitro and in vivo.	calcium phosphate	168-185	interleukin 10	Mus musculus	51-56
26436096-1	2015	The purpose of this research was to covalently graft fibroblast growth factor 2 (FGF-2) onto biphasic calcium phosphate (BCP) via a bifunctional cross-linker technique and to estimate the optimal dose of FGF-2 resulting in the best osteogenic differentiation of human mesenchymal stem cells (hMSCs).	calcium phosphate	102-119	fibroblast growth factor 2	Homo sapiens	53-79
26436096-1	2015	The purpose of this research was to covalently graft fibroblast growth factor 2 (FGF-2) onto biphasic calcium phosphate (BCP) via a bifunctional cross-linker technique and to estimate the optimal dose of FGF-2 resulting in the best osteogenic differentiation of human mesenchymal stem cells (hMSCs).	calcium phosphate	102-119	fibroblast growth factor 2	Homo sapiens	81-86
32261791-2	2014	Herein, multifunctional mesoporous microspheres of europium-doped amorphous calcium phosphate (Eu3+-doped ACP) have been prepared using a natural biomolecule adenosine triphosphate (ATP) by the rapid microwave-assisted solvothermal method.	calcium phosphate	76-93	CPAT1	Homo sapiens	106-109
26119071-12	2015	Exposure to high Pi concentration augments aortic calcification via an increase in Pit-1, which mainly contains calcium phosphate.	calcium phosphate	112-129	POU class 1 homeobox 1	Rattus norvegicus	83-88
25491277-4	2015	Evaluation of the volumetric changes of implanted biphasic calcium phosphate (HAp/beta-TCP)/collagen composite in the malar areas from baseline to 4 months, 9-12 months, and 18-24 months after surgery using cone beam computed tomography (CBCT) surface superimposition and volumetric subtraction was done.	calcium phosphate	59-76	retinoic acid receptor beta	Homo sapiens	78-81
25220281-0	2014	Effect of NELL1 gene overexpression in iPSC-MSCs seeded on calcium phosphate cement.	calcium phosphate	59-76	neural EGFL like 1	Homo sapiens	10-15
25176068-1	2014	Human mesenchymal stem cells (hMSC) have immunomodulative properties and, associated with calcium phosphate (CaP) ceramics, induce bone tissue repair.	calcium phosphate	90-107	musculin	Homo sapiens	30-34
25176068-1	2014	Human mesenchymal stem cells (hMSC) have immunomodulative properties and, associated with calcium phosphate (CaP) ceramics, induce bone tissue repair.	calcium phosphate	109-112	musculin	Homo sapiens	30-34
25518021-2	2014	Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds.	calcium phosphate	100-117	alpha 2-HS glycoprotein	Homo sapiens	0-8
24935525-1	2014	To confirm the effect of recombinant human bone morphogenetic protein-2 (BMP-2) for bone regeneration, BMP-2-loaded polycaprolactone (PCL)-gelatin (Gel)-biphasic calcium phosphate (BCP) fibrous scaffolds were fabricated using the electrospinning method.	calcium phosphate	162-179	bone morphogenetic protein 2	Homo sapiens	103-108
25421321-2	2014	Treatment of bone marrow macrophages (BMMs) with receptor activator of nuclear factor kappaB ligand (RANKL) resulted in a differentiation of BMMs into osteoclasts as evidenced by generation of tartrate-resistant acid phosphatase (TRAP)-positive, multinucleated cells and formation of pits in calcium phosphate-coated plates.	calcium phosphate	292-309	TNF superfamily member 11	Homo sapiens	49-99
25421321-2	2014	Treatment of bone marrow macrophages (BMMs) with receptor activator of nuclear factor kappaB ligand (RANKL) resulted in a differentiation of BMMs into osteoclasts as evidenced by generation of tartrate-resistant acid phosphatase (TRAP)-positive, multinucleated cells and formation of pits in calcium phosphate-coated plates.	calcium phosphate	292-309	TNF superfamily member 11	Homo sapiens	101-106
32261804-3	2014	By the addition of calcium phosphate into the inner aqueous phase of the W1/O/W2-emulsion, the encapsulation efficiency of siRNA was increased to 37%, of DNA to 52%, and of bovine serum albumin to 78%, i.e. by a factor of 3 to 10 compared to PLGA nanoparticles without calcium phosphate.	calcium phosphate	19-36	albumin	Homo sapiens	180-193
23038649-3	2014	To improve GG suitability as a material for bone TE, alkaline phosphatase (ALP), an enzyme involved in mineralization of bone by cleaving phosphate from organic phosphate, was incorporated into GG hydrogels to induce mineralization with calcium phosphate (CaP).	calcium phosphate	237-254	alkaline phosphatase, placental	Homo sapiens	53-73
25245204-3	2014	We aimed to develop composites of beta-TCP ceramics and receptor activator of nuclear factor kappa-B ligand (RANKL) to enhance the formation of osteoclasts and promote cell mediated calcium phosphate resorption.	calcium phosphate	182-199	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	109-114
25245204-4	2014	RANKL was adsorbed superficially onto beta-TCP ceramics or incorporated into a crystalline layer of calcium phosphate by the use of a co-precipitation technique.	calcium phosphate	100-117	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	0-5
25245204-12	2014	Incorporated RANKL stimulated the cells to resorb crystalline calcium phosphate.	calcium phosphate	62-79	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	13-18
25100227-3	2014	Herein, core-shell hollow microspheres of magnetic iron oxide@amorphous calcium phosphate (MIO@ACP) were prepared and investigated as magnetic, pH-responsive drug nanocarriers.	calcium phosphate	72-89	meiosis regulator for oocyte development	Homo sapiens	91-98
24817643-4	2014	PAM is pathologically attributable to the formation and aggregation of calcium phosphate microliths in the alveoli after mutations in the SLC34A2 gene (the type IIb sodium-phosphate cotransporter gene) coding NaPi-IIb.	calcium phosphate	71-88	solute carrier family 34 member 2	Homo sapiens	138-145
25317993-13	2014	CONCLUSIONS: Bone morphogenetic protein type 2 increased bone regeneration in experimental skull reconstruction, especially when combined to calcium phosphate.	calcium phosphate	141-158	bone morphogenetic protein 2	Mus musculus	13-46
25212438-4	2014	SCL20A2 encodes the Type III sodium-dependent inorganic phosphate (Pi) transporter 2 (PiT2) and, when mutated, uptake of Pi is severely impaired likely causing buildup of calcium phosphate.	calcium phosphate	171-188	solute carrier family 20 member 2	Homo sapiens	86-90
24939077-0	2014	PEGylated carboxymethyl chitosan/calcium phosphate hybrid anionic nanoparticles mediated hTERT siRNA delivery for anticancer therapy.	calcium phosphate	33-50	telomerase reverse transcriptase	Homo sapiens	89-94
24939077-2	2014	In this study, we synthesized a pH-sensitive polymer of PEG grafted carboxymethyl chitosan (PEG-CMCS) and developed anionic-charged hybrid nanoparticles of PEG-CMCS and calcium phosphate (CaP) for siRNA delivery through a single-step self-assembly method in aqueous condition.	calcium phosphate	169-186	G protein signaling modulator 2	Homo sapiens	96-100
23458515-0	2014	A novel BMP2-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particle: a biodegradable and highly efficient osteoinducer.	calcium phosphate	65-82	bone morphogenetic protein 2	Rattus norvegicus	8-12
23458515-3	2014	In this study, we hypothesized that our novel particles of biomimetic BMP2-coprecipitated calcium phosphate (BMP2-cop.BioCaP) could serve as an independent and biodegradable osteoinducer to induce bone formation efficiently for these bone-defect-filling materials, for example, deproteinized bovine bone (DBB).	calcium phosphate	90-107	bone morphogenetic protein 2	Bos taurus	70-74
23458515-3	2014	In this study, we hypothesized that our novel particles of biomimetic BMP2-coprecipitated calcium phosphate (BMP2-cop.BioCaP) could serve as an independent and biodegradable osteoinducer to induce bone formation efficiently for these bone-defect-filling materials, for example, deproteinized bovine bone (DBB).	calcium phosphate	90-107	bone morphogenetic protein 2	Bos taurus	109-113
24754833-0	2014	Calcium phosphate particles induce interleukin-8 expression in a human gingival epithelial cell line via the nuclear factor-kappaB signaling pathway.	calcium phosphate	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
24754833-3	2014	The authors examined the effect of nano/microsized calcium phosphate particles, which may be generated in the process of early precipitation and/or dissolution of calcium phosphate mineral, on the expression of interleukin (IL)-8 in human gingival epithelial cells.	calcium phosphate	51-68	C-X-C motif chemokine ligand 8	Homo sapiens	211-229
23038605-4	2014	Alkaline phosphatase (ALP) activity and mRNA expression of various osteogenic markers increased significantly when cells were co-cultured on materials with calcium phosphate scaffolds compared to tissue culture polystyrene or when MSCs were cultured alone.	calcium phosphate	156-173	alkaline phosphatase, placental	Homo sapiens	0-20
23038605-4	2014	Alkaline phosphatase (ALP) activity and mRNA expression of various osteogenic markers increased significantly when cells were co-cultured on materials with calcium phosphate scaffolds compared to tissue culture polystyrene or when MSCs were cultured alone.	calcium phosphate	156-173	alkaline phosphatase, placental	Homo sapiens	22-25
25206304-4	2014	After a simulated body fluid (SBF) immersion test, the COL/PCL/nHA-SBF scaffold developed a rough surface because of the calcium phosphate deposited on the fibers, suggesting that the presence of nHA promoted the mineralization potential of the scaffold.	calcium phosphate	121-138	PHD finger protein 1	Homo sapiens	59-62
24964203-6	2014	The proteolytic pattern observed suggests that plasmin destabilizes the casein micelle by hydrolyzing casein-casein and casein-calcium phosphate interaction sites, which may subsequently cause age gelation in UHT milk.	calcium phosphate	127-144	plasminogen	Homo sapiens	47-54
25158174-5	2014	The effect of P148 and P173 concentrations (0.2-2.0 mg/ml) on the rate of spontaneous calcium phosphate precipitation was monitored via changes in solution pH, while mineral phases formed were assessed using TEM.	calcium phosphate	86-103	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	23-27
24954647-3	2014	METHODS: Nanoparticles of amorphous calcium phosphate (NACP) and a quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM) were synthesized.	calcium phosphate	36-53	synuclein alpha	Homo sapiens	55-59
24931105-1	2014	PURPOSE: The objectives of this study were to confirm the osteogenic potential of the Schneiderian membrane and to elucidate the early healing pattern of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2)-coated biphasic calcium phosphate (BCP).	calcium phosphate	236-253	bone morphogenetic protein 2	Homo sapiens	181-209
24120484-3	2014	When compared to conventional aluminium-adjuvanted formulations, PCMCs modified with calcium phosphate (CaP) showed enhanced antigen-specific IgG responses and a decreased antigen-specific IgG1:IgG2a ratio, indicating the induction of a more balanced Th1/Th2 response.	calcium phosphate	85-102	LOC105243590	Mus musculus	189-193
24120484-3	2014	When compared to conventional aluminium-adjuvanted formulations, PCMCs modified with calcium phosphate (CaP) showed enhanced antigen-specific IgG responses and a decreased antigen-specific IgG1:IgG2a ratio, indicating the induction of a more balanced Th1/Th2 response.	calcium phosphate	85-102	immunoglobulin heavy variable V1-9	Mus musculus	194-199
24120484-3	2014	When compared to conventional aluminium-adjuvanted formulations, PCMCs modified with calcium phosphate (CaP) showed enhanced antigen-specific IgG responses and a decreased antigen-specific IgG1:IgG2a ratio, indicating the induction of a more balanced Th1/Th2 response.	calcium phosphate	85-102	negative elongation factor complex member C/D, Th1l	Mus musculus	251-254
24120484-3	2014	When compared to conventional aluminium-adjuvanted formulations, PCMCs modified with calcium phosphate (CaP) showed enhanced antigen-specific IgG responses and a decreased antigen-specific IgG1:IgG2a ratio, indicating the induction of a more balanced Th1/Th2 response.	calcium phosphate	85-102	heart and neural crest derivatives expressed 2	Mus musculus	255-258
24738890-0	2014	Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.	calcium phosphate	34-51	bone morphogenetic protein 2	Homo sapiens	94-99
24704898-1	2014	We investigate whether a novel and inexpensive etching method, H3PO4 + NaF, on titanium could obtain both a lower hydrogen content and superior calcium phosphate deposition performance, while achieving similar surface roughness in comparison with the traditional etching method.	calcium phosphate	144-161	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
24858339-0	2014	Influence of apolipoprotein E, age and aortic site on calcium phosphate induced abdominal aortic aneurysm in mice.	calcium phosphate	54-71	apolipoprotein E	Mus musculus	13-29
24659100-0	2014	Bioactivity of porous biphasic calcium phosphate enhanced by recombinant human bone morphogenetic protein 2/silk fibroin microsphere.	calcium phosphate	31-48	bone morphogenetic protein 2	Homo sapiens	79-107
24747361-7	2014	The Mn1-betaTCP composition revealed the best set of bioactivity properties, potentially a good candidate for future applications of beta-TCP materials in osteoregeneration.	calcium phosphate	133-141	meningioma 1	Mus musculus	4-7
24849210-0	2014	Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells.	calcium phosphate	48-65	alpha 2-HS glycoprotein	Homo sapiens	0-8
24831936-8	2014	The bone-like tissue seen on the calcium phosphate scaffolds wrapped with the BMSC sheets was enclosed within a periosteum-like tissue characterized morphologically and through expression of periostin.	calcium phosphate	33-50	periostin	Homo sapiens	191-200
24849210-5	2014	In addition, CaP particles functionalised with fetuin-A, but not albumin, were less toxic than naked CaP particles.	calcium phosphate	13-16	alpha 2-HS glycoprotein	Homo sapiens	47-55
24849210-9	2014	Fetuin-A also reduced dissolution of CaP particles under acidic conditions, which may contribute to its cytoprotective effects after CaP particle exposure to VSMCs.	calcium phosphate	37-40	alpha 2-HS glycoprotein	Homo sapiens	0-8
24529587-4	2014	RESULTS: The mean serum DKK1 level in the controls was 321.7 +- 284.1 pg/mL, which was significantly lower than that of the patients with calcium oxalate and calcium phosphate (CaOx + CaP), CaOx, and CaP stones (687.8 +- 600.2, 640.5 +- 721.5, and 857.9 +- 913.2 pg/mL, respectively).	calcium phosphate	158-175	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	24-28
24347277-3	2014	Replication-defective HSV-1 vector (rdHSV-IFNgamma) was established by calcium phosphate co-transfection of complementing cells.	calcium phosphate	71-88	interferon gamma	Homo sapiens	42-50
22740314-0	2014	Induction of bone formation in biphasic calcium phosphate scaffolds by bone morphogenetic protein-2 and primary osteoblasts.	calcium phosphate	40-57	bone morphogenetic protein 2	Rattus norvegicus	71-99
24111496-1	2014	OBJECTIVE: Recent clinical studies suggest that fibroblast growth factor 23 (FGF23) is important in the pathogenesis of calcium-phosphate abnormalities in patients with chronic kidney disease and that increased plasma FGF23 concentration is a cardiovascular risk factor in these patients.	calcium phosphate	120-137	fibroblast growth factor 23	Homo sapiens	48-75
24111496-1	2014	OBJECTIVE: Recent clinical studies suggest that fibroblast growth factor 23 (FGF23) is important in the pathogenesis of calcium-phosphate abnormalities in patients with chronic kidney disease and that increased plasma FGF23 concentration is a cardiovascular risk factor in these patients.	calcium phosphate	120-137	fibroblast growth factor 23	Homo sapiens	77-82
23651333-1	2014	OBJECTIVES: The purpose was to evaluate the effect of Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2)-/epigallocatechin-3-gallate (EGCG)-coated biphasic calcium phosphate (BCP) and titanium barrier membrane on dehiscence defects in dogs.	calcium phosphate	188-205	bone morphogenetic protein 2	Homo sapiens	97-125
24275478-2	2014	Here, we show that a fusion protein between a calcium phosphate binding domain and the model antigen ovalbumin can mineralize a biocompatible adjuvant in a single step.	calcium phosphate	46-63	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	101-110
24275478-3	2014	The resulting 50 nm calcium phosphate core-immunogen shell particles are comparable to soluble protein in inducing ovalbumin-specific antibody response and class switch recombination in mice.	calcium phosphate	20-37	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	115-124
24275478-7	2014	FROM THE CLINICAL EDITOR: This paper reports that a fusion protein between a calcium phosphate binding domain and the model antigen ovalbumin can mineralize into a biocompatible adjuvant in a single step, enabling distributed and on-demand vaccine production and eliminating the need for refrigeration of vaccines.	calcium phosphate	77-94	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	132-141
24382825-2	2014	Crystallinity of HAp nanoparticles was reduced because of the interference of the surface layers of chitosan with the dissolution/reprecipitation-mediated recrystallization mechanism that conditions the transition from the as-precipitated amorphous calcium phosphate phase to the most thermodynamically stable one--HAp.	calcium phosphate	249-266	retinoic acid receptor, beta	Mus musculus	17-20
24316224-2	2014	A naturally occurring mixture of osteopontin peptides was shown, by light and neutron scattering, to form calcium phosphate nanoclusters with a core-shell structure.	calcium phosphate	106-123	secreted phosphoprotein 1	Homo sapiens	33-44
24316224-3	2014	In blood serum and stimulated saliva, an invariant calcium phosphate ion activity product was found which corresponds closely in form and magnitude to the ion activity product observed in solutions of these osteopontin nanoclusters.	calcium phosphate	51-68	secreted phosphoprotein 1	Homo sapiens	207-218
24316224-5	2014	Precipitation of amorphous calcium phosphate from artificial blood serum, urine and saliva was determined as a function of pH and the concentration of osteopontin or casein phosphopeptides.	calcium phosphate	27-44	secreted phosphoprotein 1	Homo sapiens	151-162
24157695-5	2014	Furthermore, the formed self-assembled Ca-P/polydopamine composite nanolayer significantly enhances the surface roughness and hydrophilicity of beta-TCP ceramics, and stimulates the attachment, proliferation, alkaline phosphate (ALP) activity and bone-related gene expression (ALP, OCN, COL1 and Runx2) of human bone marrow stromal cells.	calcium phosphate	39-43	bone gamma-carboxyglutamate protein	Homo sapiens	282-285
24411394-0	2014	Bio-hybrid silk fibroin/calcium phosphate/PLGA nanocomposite scaffold to control the delivery of vascular endothelial growth factor.	calcium phosphate	24-41	vascular endothelial growth factor A	Homo sapiens	97-131
24411394-1	2014	This study investigated the efficacy of bio-hybrid silk fibroin/Calcium phosphate/PLGA nanocomposite scaffold as vascular endothelial growth factor (VEGF) delivery system.	calcium phosphate	64-81	vascular endothelial growth factor A	Homo sapiens	113-147
24411394-1	2014	This study investigated the efficacy of bio-hybrid silk fibroin/Calcium phosphate/PLGA nanocomposite scaffold as vascular endothelial growth factor (VEGF) delivery system.	calcium phosphate	64-81	vascular endothelial growth factor A	Homo sapiens	149-153
24468523-9	2014	Tubular calcium phosphate deposits were also decreased in VDR silenced kidneys.	calcium phosphate	8-25	vitamin D receptor	Rattus norvegicus	58-61
24157695-5	2014	Furthermore, the formed self-assembled Ca-P/polydopamine composite nanolayer significantly enhances the surface roughness and hydrophilicity of beta-TCP ceramics, and stimulates the attachment, proliferation, alkaline phosphate (ALP) activity and bone-related gene expression (ALP, OCN, COL1 and Runx2) of human bone marrow stromal cells.	calcium phosphate	39-43	RUNX family transcription factor 2	Homo sapiens	296-301
24418082-3	2014	Calcium phosphate transfection method was used to package retrovirus pLEGFP-N1-TRPC6 and pLEGFP-N1-vector and infect the prostate cancer cells, a stable high expression of TRPC6 prostate cancer cells.	calcium phosphate	0-17	transient receptor potential cation channel subfamily C member 6	Homo sapiens	79-84
24418082-3	2014	Calcium phosphate transfection method was used to package retrovirus pLEGFP-N1-TRPC6 and pLEGFP-N1-vector and infect the prostate cancer cells, a stable high expression of TRPC6 prostate cancer cells.	calcium phosphate	0-17	transient receptor potential cation channel subfamily C member 6	Homo sapiens	172-177
24342703-5	2014	TMSB4X-transfected cells formed nodules that were positive for Alizarin-red S (ALZ) and von Kossa staining (calcium phosphate deposits) when cultured in calcification-inducing medium.	calcium phosphate	108-125	thymosin beta 4 X-linked	Homo sapiens	0-6
25401741-1	2014	BACKGROUND/AIMS: Calcium-Sensing Receptor (CaSR) significantly affects calcium-phosphate metabolism in kidneys, and it is implicated in the pathogenesis of diabetes mellitus (DM) due to its expression in pancreatic beta-cells.	calcium phosphate	71-88	calcium sensing receptor	Homo sapiens	17-41
25401741-1	2014	BACKGROUND/AIMS: Calcium-Sensing Receptor (CaSR) significantly affects calcium-phosphate metabolism in kidneys, and it is implicated in the pathogenesis of diabetes mellitus (DM) due to its expression in pancreatic beta-cells.	calcium phosphate	71-88	calcium sensing receptor	Homo sapiens	43-47
25348593-2	2014	The recently identified IBGC gene, SLC20A2, encodes for type III sodium-dependent phosphate transporter 2 and its loss-of-function mutations may lead to the regional accumulation of inorganic phosphate in the brain, causing calcium phosphate deposition.	calcium phosphate	224-241	Basal ganglia calcification, idiopathic (Fahr disease)	Homo sapiens	24-28
25348593-2	2014	The recently identified IBGC gene, SLC20A2, encodes for type III sodium-dependent phosphate transporter 2 and its loss-of-function mutations may lead to the regional accumulation of inorganic phosphate in the brain, causing calcium phosphate deposition.	calcium phosphate	224-241	solute carrier family 20 member 2	Homo sapiens	35-42
23956214-4	2014	The osteogenetic potential of the scaffolds coated with layers of CHI and BMP-2 is demonstrated in vitro, and in vivo in mouse calvaria, through enhanced osteopontin gene expression and calcium phosphate biomineralization.	calcium phosphate	186-203	bone morphogenetic protein 2	Mus musculus	74-79
24268280-8	2014	The in vitro mineralization of calcium phosphate (CP) that produces the bone-like apatite was observed on both the pure HAp scaffold and the HAp/PCL composite scaffold.	calcium phosphate	31-48	reticulon 3	Homo sapiens	120-123
24268280-8	2014	The in vitro mineralization of calcium phosphate (CP) that produces the bone-like apatite was observed on both the pure HAp scaffold and the HAp/PCL composite scaffold.	calcium phosphate	31-48	reticulon 3	Homo sapiens	141-144
25090712-2	2014	METHODS: Transfected PGL3-ID1 using the calcium phosphate co-precipitation method in rat MSCs.	calcium phosphate	40-57	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	26-29
24306695-2	2013	We evaluated rhBMP-2 and a new, injectable calcium phosphate matrix (CPM) formulation in acute closed tibial diaphyseal fractures treated with reamed intramedullary nail fixation.	calcium phosphate	43-60	carboxypeptidase M	Homo sapiens	69-72
24330694-1	2013	Pseudoxanthoma elasticum (PXE), caused by mutations in the ABCC6 gene, demonstrates progressive build-up of calcium phosphate and proteoglycans in the skin, eye, and arteries, and is associated to myocardial infarctions, stroke, blindness, and elevated carotid intima-media thickness (CIMT).	calcium phosphate	108-125	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Mus musculus	59-64
24306712-1	2013	: "Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture.	calcium phosphate	73-90	bone morphogenetic protein 2	Homo sapiens	44-72
24028822-0	2013	Growth factor gene expression profiles of bone morphogenetic protein-2-treated human adipose stem cells seeded on calcium phosphate scaffolds in vitro.	calcium phosphate	114-131	bone morphogenetic protein 2	Homo sapiens	42-70
24044997-2	2013	To address these problems, a recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded calcium silicate/calcium phosphate cement scaffold (CSPC) with hierarchical pores was developed in this study.	calcium phosphate	110-127	bone morphogenetic protein 2	Homo sapiens	47-75
23263277-6	2013	RESULTS: FKBP5 transfectants of RAW264.7 generated higher numbers of TRAP-positive multinucleated cells with increased activity of pit formation on calcium phosphate-coated culture slides than mock transfectants.	calcium phosphate	148-165	FK506 binding protein 5	Mus musculus	9-14
24004885-6	2013	To increase the encapsulation of Trp2 peptide into the calcium phosphate precipitate core of LCP, two phosphor-serine residues were added to the N-terminal of the peptide (p-Trp2).	calcium phosphate	55-72	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	33-37
23983180-8	2013	It was found that alpha-TCP/HAp bead carriers exhibit low toxicity in the initial stages of cell seeding and cell adhesion.	calcium phosphate	18-27	reticulon 3	Homo sapiens	28-31
23983180-10	2013	In conclusion, it is suggested that these newly developed alpha-TCP/HAp beads are a promising tool for bone tissue engineering.	calcium phosphate	58-67	reticulon 3	Homo sapiens	68-71
23893547-2	2013	We have previously reported that the amphiphilic and anionic beta-sheet forming peptide, Pro-Asp-(Phe-Asp)5 -Pro, P(FD)-5, generates hydrogels that template calcium-phosphate mineral and as such, were able to enhance bone formation in vivo.	calcium phosphate	157-174	prefoldin subunit 5	Homo sapiens	114-121
23490272-1	2013	This study was aimed to explore the role of serum fibroblast growth factor (FGF)-23, matrix Gla protein (MGP) and fetuin-A in the calcium-phosphate metabolism and their predicting value in coronary artery calcification in maintenance hemodialysis (MHD) patients.	calcium phosphate	130-147	fibroblast growth factor 23	Homo sapiens	50-83
23529979-0	2013	RANKL delivery from calcium phosphate containing PLGA microspheres.	calcium phosphate	20-37	TNF superfamily member 11	Homo sapiens	0-5
23529979-2	2013	In an attempt to exploit the capacity of Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) to stimulate osteoclast-like cells formation, this study explored different loading methods for RANKL in injectable calcium phosphate cement (CPC) and the effect on release and biological activity.	calcium phosphate	217-234	TNF superfamily member 11	Homo sapiens	94-99
23529979-2	2013	In an attempt to exploit the capacity of Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) to stimulate osteoclast-like cells formation, this study explored different loading methods for RANKL in injectable calcium phosphate cement (CPC) and the effect on release and biological activity.	calcium phosphate	217-234	TNF superfamily member 11	Homo sapiens	197-202
23891395-3	2013	The objectives of this study were to: (1) genetically modify iPSC-MSCs for BMP2 delivery; and (2) to seed BMP2 gene-modified iPSC-MSCs on calcium phosphate cement (CPC) immobilized with RGD for bone tissue engineering.	calcium phosphate	138-155	bone morphogenetic protein 2	Homo sapiens	106-110
23945076-1	2013	Membranes of the autologous blood-derived biomaterial platelet-rich fibrin (PRF) were mineralized enzymatically with calcium phosphate (CaP) by the incorporation of alkaline phosphatase (ALP) followed by incubation for 3 days in solutions of either 0.1 M calcium glycerophosphate (CaGP) or a combination of CaGP and magnesium glycerophosphate (CaGP:MgGP; both 0.05 M), resulting in the formation of two different PRF-mineral composites.	calcium phosphate	117-134	alkaline phosphatase, placental	Homo sapiens	165-185
23945076-1	2013	Membranes of the autologous blood-derived biomaterial platelet-rich fibrin (PRF) were mineralized enzymatically with calcium phosphate (CaP) by the incorporation of alkaline phosphatase (ALP) followed by incubation for 3 days in solutions of either 0.1 M calcium glycerophosphate (CaGP) or a combination of CaGP and magnesium glycerophosphate (CaGP:MgGP; both 0.05 M), resulting in the formation of two different PRF-mineral composites.	calcium phosphate	117-134	alkaline phosphatase, placental	Homo sapiens	187-190
23945076-1	2013	Membranes of the autologous blood-derived biomaterial platelet-rich fibrin (PRF) were mineralized enzymatically with calcium phosphate (CaP) by the incorporation of alkaline phosphatase (ALP) followed by incubation for 3 days in solutions of either 0.1 M calcium glycerophosphate (CaGP) or a combination of CaGP and magnesium glycerophosphate (CaGP:MgGP; both 0.05 M), resulting in the formation of two different PRF-mineral composites.	calcium phosphate	136-139	alkaline phosphatase, placental	Homo sapiens	165-185
23945076-1	2013	Membranes of the autologous blood-derived biomaterial platelet-rich fibrin (PRF) were mineralized enzymatically with calcium phosphate (CaP) by the incorporation of alkaline phosphatase (ALP) followed by incubation for 3 days in solutions of either 0.1 M calcium glycerophosphate (CaGP) or a combination of CaGP and magnesium glycerophosphate (CaGP:MgGP; both 0.05 M), resulting in the formation of two different PRF-mineral composites.	calcium phosphate	136-139	alkaline phosphatase, placental	Homo sapiens	187-190
23490272-1	2013	This study was aimed to explore the role of serum fibroblast growth factor (FGF)-23, matrix Gla protein (MGP) and fetuin-A in the calcium-phosphate metabolism and their predicting value in coronary artery calcification in maintenance hemodialysis (MHD) patients.	calcium phosphate	130-147	matrix Gla protein	Homo sapiens	85-103
23490272-1	2013	This study was aimed to explore the role of serum fibroblast growth factor (FGF)-23, matrix Gla protein (MGP) and fetuin-A in the calcium-phosphate metabolism and their predicting value in coronary artery calcification in maintenance hemodialysis (MHD) patients.	calcium phosphate	130-147	matrix Gla protein	Homo sapiens	105-108
23490272-1	2013	This study was aimed to explore the role of serum fibroblast growth factor (FGF)-23, matrix Gla protein (MGP) and fetuin-A in the calcium-phosphate metabolism and their predicting value in coronary artery calcification in maintenance hemodialysis (MHD) patients.	calcium phosphate	130-147	alpha 2-HS glycoprotein	Homo sapiens	114-122
32481960-2	2013	Herein, vitamin B6 (pyridoxal-5"-phosphate, PLP) functionalized calcium phosphate (CP) is used as the bio-recyclable nanocarrier for delivery of proteins into cells.	calcium phosphate	64-81	proteolipid protein 1	Homo sapiens	44-47
23856159-0	2013	Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold.	calcium phosphate	101-118	vascular endothelial growth factor A	Homo sapiens	56-90
24039232-5	2013	By contrast, when rFBN1-N was immobilized on calcium phosphate, it did not affect osteoclastogenesis but modulated osteoclast resorptive activity, which was evident by a larger number of smaller resorption pits.	calcium phosphate	45-62	fibrillin 1	Rattus norvegicus	18-23
23911496-10	2013	Interestingly, the mineralized CD-NPs released CAB in a sustained manner for 21 days, which was due to the stable calcium phosphate barrier inhibiting CAB release.	calcium phosphate	114-131	carbonic anhydrase 2	Homo sapiens	47-50
23911496-10	2013	Interestingly, the mineralized CD-NPs released CAB in a sustained manner for 21 days, which was due to the stable calcium phosphate barrier inhibiting CAB release.	calcium phosphate	114-131	carbonic anhydrase 2	Homo sapiens	151-154
24039882-7	2013	CONCLUSIONS: In cardiology department inpatients, circulating FGF23 concentrations were found to be associated with the left ventricular mass and LVEF independent of renal function and other calcium-phosphate metabolism-related parameters.	calcium phosphate	191-208	fibroblast growth factor 23	Homo sapiens	62-67
23856159-2	2013	In an attempt to address these issues, we developed a nanocomposite scaffold based on silk/calcium phosphate/PLGA by freeze-drying and electrospinning in order to control the release of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF).	calcium phosphate	91-108	vascular endothelial growth factor A	Homo sapiens	228-262
23856159-2	2013	In an attempt to address these issues, we developed a nanocomposite scaffold based on silk/calcium phosphate/PLGA by freeze-drying and electrospinning in order to control the release of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF).	calcium phosphate	91-108	vascular endothelial growth factor A	Homo sapiens	264-268
24023640-11	2013	The efficiency of new bone formation was dramatically enhanced in vivo in Ad-CGRP-ADSCs/beta-TCP group but not in beta-TCP group and ADSCs/beta-TCP group.	calcium phosphate	88-96	calcitonin-related polypeptide alpha	Rattus norvegicus	77-81
23732874-3	2013	In order to render DBB osteoinductive, bone morphogenetic protein 2 (BMP-2) has previously been incorporated into a three dimensional reservoir (a biomimetic calcium phosphate coating) on DBB, which effectively promoted the osteogenic response by the slow delivery of BMP-2.	calcium phosphate	158-175	bone morphogenetic protein 2	Bos taurus	39-67
23732874-3	2013	In order to render DBB osteoinductive, bone morphogenetic protein 2 (BMP-2) has previously been incorporated into a three dimensional reservoir (a biomimetic calcium phosphate coating) on DBB, which effectively promoted the osteogenic response by the slow delivery of BMP-2.	calcium phosphate	158-175	bone morphogenetic protein 2	Bos taurus	69-74
23732874-12	2013	In conclusion, it was shown that incorporating BMP-2 into the calcium phosphate coating of DBB induced strong bone formation around DBB for repairing a critical-sized bone defect.	calcium phosphate	62-79	bone morphogenetic protein 2	Bos taurus	47-52
23830037-1	2013	OBJECTIVE: The aim of the study was to analyze the value of Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) coated biphasic calcium phosphate (BCP) for the obliteration of middle ear bone defect after mastoid surgery.	calcium phosphate	159-176	bone morphogenetic protein 2	Homo sapiens	103-131
23849774-5	2013	The process of aortic valve leaflet calcification has been associated with the deposition of calcium phosphate, mediated in part by the phosphate inorganic transporter 1 (PiT-1), a sodium-phosphate ion cotransporter.	calcium phosphate	93-110	solute carrier family 20 member 1	Homo sapiens	136-169
23849774-5	2013	The process of aortic valve leaflet calcification has been associated with the deposition of calcium phosphate, mediated in part by the phosphate inorganic transporter 1 (PiT-1), a sodium-phosphate ion cotransporter.	calcium phosphate	93-110	solute carrier family 20 member 1	Homo sapiens	171-176
23403025-2	2013	ALP incorporation led to acceleration of gelation upon increase of temperature for four different chitosan preparations of differing molecular weight, as demonstrated by rheometric time sweeps at 37  C. Hydrogels containing ALP were subsequently incubated in calcium glycerophosphate (Ca-GP) solution to induce their mineralization with calcium phosphate (CaP) in order to improve their suitability as materials for bone replacement.	calcium phosphate	337-354	alkaline phosphatase, placental	Homo sapiens	0-3
23611495-1	2013	A specific and simple competitive enzyme-linked immunosorbent assay (ELISA) was developed to determine bovine beta-casein phosphopeptides (beta-CPP) in casein phosphopeptides (CPP) or CPP complexes such as casein phosphopeptide amorphous calcium phosphate complexes added into dairy products.	calcium phosphate	238-255	casein beta	Bos taurus	110-121
23752904-8	2013	In the same time frame, beta-TCP induced expression of G-protein coupled receptor (GPCR) 5A and regulator of G-protein signaling 2, revealed by DNA microarray analysis.	calcium phosphate	24-32	C-X-C motif chemokine receptor 6	Homo sapiens	55-81
23752904-8	2013	In the same time frame, beta-TCP induced expression of G-protein coupled receptor (GPCR) 5A and regulator of G-protein signaling 2, revealed by DNA microarray analysis.	calcium phosphate	24-32	C-X-C motif chemokine receptor 6	Homo sapiens	83-87
23534940-8	2013	Bone marrow cells from Bdkrb1(-/-) displayed increased differentiation into functional osteoclasts with consistent artificial calcium phosphate degradation.	calcium phosphate	126-143	bradykinin receptor, beta 1	Mus musculus	23-29
23815901-1	2013	In order to study the potential of Venus, lentiviral vector, applied to acute myeloid leukemia, the recombinant vector Venus-C3aR was transfected into 293T packing cells by DNA-calcium phosphate coprecipitation.	calcium phosphate	177-194	complement C3a receptor 1	Homo sapiens	125-129
27877575-2	2013	The FGF-2-AsMg-Ap coated Ti plate was prepared by immersing a Ti plate in supersaturated calcium phosphate solutions supplemented with FGF-2 and AsMg.	calcium phosphate	89-106	fibroblast growth factor 2	Homo sapiens	4-9
23465492-0	2013	Osteoinductivity of calcium phosphate mediated by connexin 43.	calcium phosphate	20-37	gap junction protein alpha 1	Homo sapiens	50-61
23465492-3	2013	We demonstrate that amorphous calcium phosphate (ACP) alters cellular functions and 3D spatial tissue differentiation patterns by increasing local calcium concentration, which modulates connexin 43 (Cx43)-mediated gap junctions.	calcium phosphate	30-47	gap junction protein alpha 1	Homo sapiens	186-197
23465492-3	2013	We demonstrate that amorphous calcium phosphate (ACP) alters cellular functions and 3D spatial tissue differentiation patterns by increasing local calcium concentration, which modulates connexin 43 (Cx43)-mediated gap junctions.	calcium phosphate	30-47	gap junction protein alpha 1	Homo sapiens	199-203
23419133-10	2013	By Cox proportional-hazards regression, patients with higher fetuin A levels experienced lower incidence of stroke, hazard ratio (HR) of 0 89 (95% CI, 0 84-0 96), while those with higher mean arterial blood pressure had an HR of 1 19 (95% CI, 1 07-1 34) and those with higher calcium phosphate product (CaxP) had an HR of 1 39 (95% CI, 1 1-1 73) for having strokes.	calcium phosphate	276-293	alpha 2-HS glycoprotein	Homo sapiens	61-69
23643262-5	2013	The constructed TRAF3IP3 eukaryotic expression plasmid was transfected into HEK293 cells by calcium phosphate precipitation method.	calcium phosphate	92-109	TRAF3 interacting protein 3	Homo sapiens	16-24
22962037-0	2013	Calcium phosphate cements loaded with basic fibroblast growth factor: delivery and in vitro cell response.	calcium phosphate	0-17	fibroblast growth factor 2	Mus musculus	38-68
23741096-2	2013	Although, etiology and pathogenesis of PAM is not fully understood, the mutation in SLC34A2 gene that encodes a sodium-phosphate co-transporter in alveolar type II cells resulting in the accumulation and forming of microliths rich in calcium phosphate (due to impaired clearance) are considered to be the cause of the disease.	calcium phosphate	234-251	solute carrier family 34 member 2	Homo sapiens	84-91
23201201-8	2013	CONCLUSION: These in vitro studies showed that the chemistry of the protein solutions can significantly alter the processing of amelogenin by MMP-20, which may have significant effects in vivo matrix assembly and subsequent calcium phosphate mineralization.	calcium phosphate	224-241	matrix metallopeptidase 20	Homo sapiens	142-148
23107046-6	2013	rDMP1 treated samples promoted deposition of amorphous calcium phosphate (ACP) precursors and needle shaped hydroxyapatite crystals surrounding collagen fibrils.	calcium phosphate	55-72	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	0-5
23107046-9	2013	Results from rDMP1 immobilized on dentine matrix suggests that the acidic protein was able to bind to collagen fibrils and control formation of amorphous calcium phosphate and its subsequent transformation into hydroxyapatite crystals after 2 weeks.	calcium phosphate	154-171	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	13-18
23318176-2	2013	An FGF2 apatite coating was developed as a slow-releasing drug delivery system (DDS) by forming an FGF2/calcium phosphate composite layer.	calcium phosphate	104-121	fibroblast growth factor 2	Rattus norvegicus	3-7
23140916-3	2013	The objectives of this study were to investigate the caries-inhibition effect of nanocomposite containing nanoparticles of amorphous calcium phosphate (NACP) in a human in situ model for the first time, and to determine colony-forming units (CFU) and Ca and P ion concentrations of biofilms on the composite restorations.	calcium phosphate	133-150	synuclein alpha	Homo sapiens	152-156
23413976-2	2013	We aimed to describe the effect of the calcium phosphate product (Ca*P) on FGF-23 concentrations in children and young adults without confounding cardiovascular disease.	calcium phosphate	39-56	fibroblast growth factor 23	Homo sapiens	75-81
23138046-4	2013	The objectives of this study were to incorporate nanoparticles of silver (NAg) and nanoparticles of amorphous calcium phosphate (NACP) into adhesive for the first time, and to investigate the effects on dentin bond strength and plaque microcosm biofilms.	calcium phosphate	110-127	synuclein alpha	Homo sapiens	129-133
22524330-2	2013	The aim of this study is to evaluate the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) associated with bone substitute materials beta-tricalcium phosphate (beta-TCP), biphasic calcium phosphate (BCP), and bovine bone mineral on vertical guided bone regeneration (GBR) in rabbit calvarium.	calcium phosphate	158-175	bone morphogenetic protein 2	Homo sapiens	69-97
22286209-4	2013	A dye was used to characterize the 2-spinnerette approach and applicability to tissue engineering was demonstrated by fabricating nanofibers with gradients in amorphous calcium phosphate nanoparticles (nACP).	calcium phosphate	169-186	synuclein, alpha	Mus musculus	202-206
23298834-1	2013	Klotho is a potent regulator of 1,25-hydroxyvitamin D3 [1,25(OH)2D3] formation and calcium-phosphate metabolism.	calcium phosphate	83-100	klotho	Mus musculus	0-6
23351879-9	2013	Shorter total operative time, greater tolerance of early weight bearing, improved early functional outcomes within the first year post-surgery was also recorded in the studies reporting on the use of injectable calcium phosphate cement (Norian SRS).	calcium phosphate	211-228	Russell-Silver dwarfism	Homo sapiens	244-247
23075297-0	2013	Short (15 minutes) bone morphogenetic protein-2 treatment stimulates osteogenic differentiation of human adipose stem cells seeded on calcium phosphate scaffolds in vitro.	calcium phosphate	134-151	bone morphogenetic protein 2	Homo sapiens	19-47
23075297-2	2013	Toward this goal it was investigated whether short (minutes) incubation with bone morphogenetic protein-2 (BMP-2) suffices to trigger osteogenic differentiation of hASCs seeded on calcium phosphate carriers.	calcium phosphate	180-197	bone morphogenetic protein 2	Homo sapiens	107-112
23075297-10	2013	In conclusion, 15 min BMP-2 preincubation of hASCs seeded on BCP/beta-TCP scaffolds had a long-lasting stimulating effect on osteogenic differentiation in vitro.	calcium phosphate	65-73	bone morphogenetic protein 2	Homo sapiens	22-27
24189409-5	2013	MG63 cells 3-dimensionally cultured in a "HAp/Col sponge," a porous HAp/Col having sponge-like viscoelasticity, accumulated calcium phosphate nodules on extracellular matrices they secreted.	calcium phosphate	124-141	reticulon 3	Homo sapiens	42-45
23935637-4	2013	The supposed mechanism is that zonisamide induces urine alkalinization and then promotes crystallization of urine components such as calcium phosphate by inhibition of carbonate dehydratase in renal tubular epithelial cells.	calcium phosphate	133-150	carbonic anhydrase 8	Homo sapiens	168-189
22902178-2	2012	Fetuin-A mediates the formation and stabilization of calciprotein particles (CPPs), soluble colloids made of fetuin-A, further serum proteins, and calcium phosphate mineral.	calcium phosphate	147-164	alpha 2-HS glycoprotein	Homo sapiens	0-8
24455835-0	2013	[Gene polymorphism of the vitamin D receptor, vitamin D-binding protein and calcium-sensing receptor in respect of calcium-phosphate disturbances in chronic dialysis patients].	calcium phosphate	115-132	vitamin D receptor	Homo sapiens	26-44
24455835-0	2013	[Gene polymorphism of the vitamin D receptor, vitamin D-binding protein and calcium-sensing receptor in respect of calcium-phosphate disturbances in chronic dialysis patients].	calcium phosphate	115-132	calcium sensing receptor	Homo sapiens	76-100
22733619-1	2012	Block-type biphasic calcium phosphate (BCP) carriers are more effective at delivering recombinant human bone morphogenetic protein-2 (rhBMP-2) in various clinical situations than are particle-type carriers, due to their potential for highly successful three-dimensional bone regeneration.	calcium phosphate	20-37	bone morphogenetic protein 2	Homo sapiens	104-132
23198937-0	2012	Injectable calcium phosphate cement and fibrin sealant recombined human bone morphogenetic protein-2 composite in vertebroplasty: an animal study.	calcium phosphate	11-28	bone morphogenetic protein 2	Homo sapiens	72-100
23198937-2	2012	Our study evaluated the feasibility of injectable calcium phosphate cement (ICPC) and fibrin sealant (FS) as an injectable compound carrier of human bone morphogenetic protein-2 (rhBMP-2) in New Zealand rabbits for vertebroplasty.	calcium phosphate	50-67	bone morphogenetic protein 2	Homo sapiens	149-177
22618762-5	2012	BMP-2 was delivered to the repair site using either a calcium phosphate matrix (CPM) or a collagen sponge (COL) carrier.	calcium phosphate	54-71	bone morphogenetic protein 2	Canis lupus familiaris	0-5
23577176-1	2013	The formation of fetuin-A-containing calciprotein particles (CPP) may facilitate the clearance of calcium phosphate nanocrystals from the extracellular fluid.	calcium phosphate	98-115	alpha-2-HS-glycoprotein	Mus musculus	17-25
22800584-0	2012	Differential loading methods for BMP-2 within injectable calcium phosphate cement.	calcium phosphate	57-74	bone morphogenetic protein 2	Rattus norvegicus	33-38
23035874-7	2012	METHODS: Various BCL10GFP constructs were transfected into HEK293T cell with MALT1 construct by using calcium phosphate-DNA precipitation method.	calcium phosphate	102-119	BCL10 immune signaling adaptor	Homo sapiens	17-22
23035874-7	2012	METHODS: Various BCL10GFP constructs were transfected into HEK293T cell with MALT1 construct by using calcium phosphate-DNA precipitation method.	calcium phosphate	102-119	MALT1 paracaspase	Homo sapiens	77-82
22924693-1	2012	In the native bovine casein micelle the calcium sensitive caseins (alpha(S1)-, alpha(S2)- and beta-casein) sequester amorphous calcium phosphate in nanometer-sized clusters, whereas the calcium-insensitive kappa-casein limits the growth of the micelle.	calcium phosphate	127-144	casein beta	Bos taurus	94-105
23032587-2	2012	The purpose of the present study was to evaluate the efficacy of rhBMP-2/calcium phosphate matrix (CPM) to induce bone formation while limiting transient bone resorption in nonhuman primate core defects.	calcium phosphate	73-90	carboxypeptidase M	Homo sapiens	99-102
22777876-3	2012	We show that aluminium hydroxide, aluminium phosphate, and calcium phosphate adjuvants inhibit the secretion of the Th1 polarizing cytokine, IL-12 by dendritic cells (DCs).	calcium phosphate	59-76	negative elongation factor complex member C/D	Homo sapiens	116-119
22734611-0	2012	Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.	calcium phosphate	33-50	lactotransferrin	Bos taurus	80-91
22933607-2	2012	The objective of this study was to investigate the remineralization of demineralized human enamel in vitro via a nanocomposite containing nanoparticles of amorphous calcium phosphate (NACP).	calcium phosphate	165-182	synuclein alpha	Homo sapiens	184-188
22877365-1	2012	Calcium-phosphate mineralization was monitored in systems composed of designed amphiphilic and acidic beta-sheet-forming peptides, namely Pro-Phe-(Asp-Phe)(5)-Pro (PFD-5), Pro-Phe-(Glu-Phe)(5)-Pro (PFE-5) and Pro-Glu-(Phe-PSer)(4)-Phe-Glu-Pro (PPS).	calcium phosphate	0-17	prefoldin subunit 5	Homo sapiens	164-169
22639151-2	2012	PTH has been incorporated into a biomimetic calcium phosphate (CaP) coating via a co-precipitation method in a modified simulated body fluid.	calcium phosphate	44-61	parathyroid hormone	Mus musculus	0-3
22899678-6	2012	These casein phosphopeptide-stabilized amorphous calcium phosphate nanocomplexes (CPP-ACP) can stabilize even higher concentrations of calcium and phosphate than milk and can be considered a salivary biomimetic, since they share many similarities to statherin.	calcium phosphate	49-66	statherin	Homo sapiens	250-259
22796540-2	2012	Matrix Gla protein (MGP), an inhibitor of calcification, limits calcium phosphate deposition in the vessel wall.	calcium phosphate	64-81	matrix Gla protein	Homo sapiens	0-18
22796540-2	2012	Matrix Gla protein (MGP), an inhibitor of calcification, limits calcium phosphate deposition in the vessel wall.	calcium phosphate	64-81	matrix Gla protein	Homo sapiens	20-23
22819845-7	2012	In vitro experiments showed that calcium phosphate crystals induced caspase-1 activation and secretion of IL-1beta and IL-1alpha in macrophages.	calcium phosphate	33-50	caspase 1	Mus musculus	68-77
22819845-7	2012	In vitro experiments showed that calcium phosphate crystals induced caspase-1 activation and secretion of IL-1beta and IL-1alpha in macrophages.	calcium phosphate	33-50	interleukin 1 beta	Mus musculus	106-114
22819845-7	2012	In vitro experiments showed that calcium phosphate crystals induced caspase-1 activation and secretion of IL-1beta and IL-1alpha in macrophages.	calcium phosphate	33-50	interleukin 1 alpha	Mus musculus	119-128
23610684-10	2012	CONCLUSIONS: Functionalisation of alpha-TCP/PLGA with BMP-2 produced osteoinduction and was dose-dependent.	calcium phosphate	34-43	bone morphogenetic protein 2	Mus musculus	54-59
22580114-0	2012	Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.	calcium phosphate	80-97	vascular endothelial growth factor A	Homo sapiens	56-60
22578992-17	2012	NACP-QADM nanocomposite with calcium phosphate fillers, good mechanical properties and a strong antibacterial activity may have potential for anti-biofilm and anti-caries restorations.	calcium phosphate	29-46	synuclein alpha	Homo sapiens	0-4
22534475-4	2012	We hypothesize that this end could be achieved by incorporating BMP-2 into the three-dimensional crystalline latticework of a bone-mineral like, calcium-phosphate implant coating, where from it would be liberated gradually - as the inorganic layer undergoes osteoclast-mediated degradation - not rapidly, as from an implant-adsorbed (two-dimensional) depot.	calcium phosphate	145-162	bone morphogenetic protein 2	Homo sapiens	64-69
22934504-1	2012	OBJECTIVE: We ascertained the effect of bone morphogenetic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) by a series of experiments: Proliferation and differentiation of bone marrow stromal cells (BMSCs) in vitro, ectopic and in situ bone formation and loaded porous calcium phosphate cement (CPC) on the repair of bone defects around dental implants.	calcium phosphate	281-298	bone morphogenetic protein 2	Canis lupus familiaris	70-75
22934504-1	2012	OBJECTIVE: We ascertained the effect of bone morphogenetic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) by a series of experiments: Proliferation and differentiation of bone marrow stromal cells (BMSCs) in vitro, ectopic and in situ bone formation and loaded porous calcium phosphate cement (CPC) on the repair of bone defects around dental implants.	calcium phosphate	281-298	fibroblast growth factor 2	Canis lupus familiaris	113-117
22648976-1	2012	Alkaline phosphatase (ALP), an enzyme involved in mineralization of bone, is incorporated into three hydrogel biomaterials to induce their mineralization with calcium phosphate (CaP).	calcium phosphate	159-176	alkaline phosphatase, placental	Homo sapiens	0-20
22648976-1	2012	Alkaline phosphatase (ALP), an enzyme involved in mineralization of bone, is incorporated into three hydrogel biomaterials to induce their mineralization with calcium phosphate (CaP).	calcium phosphate	159-176	alkaline phosphatase, placental	Homo sapiens	22-25
22554017-12	2012	FGF23 is increased in children after PRT, especially in patients with chronic allograft dysfunction, and seems to be a more sensitive marker of dysregulated calcium phosphate homeostasis than PTH.	calcium phosphate	157-174	fibroblast growth factor 23	Homo sapiens	0-5
23610684-3	2012	The aims of this study were to synthesise bioactive BMP-2, combine it with a novel alpha-tricalcium phosphate/poly(D,L-lactide-co-glycolide) (alpha-TCP/PLGA) nanocomposite and study its release from the composite.	calcium phosphate	142-151	bone morphogenetic protein 2	Mus musculus	52-57
23610684-7	2012	Functionalisation of alpha-TCP/PLGA nanocomposite by adsorption of BMP-2 was performed and release of BMP-2 was characterised using an enzyme-linked immunosorbent assay (ELISA).	calcium phosphate	21-30	bone morphogenetic protein 2	Mus musculus	67-72
22514160-4	2012	The objective of this study was to investigate the wear, thermal-cycling, and water-aging of composites containing amorphous calcium phosphate nanoparticles (NACP).	calcium phosphate	125-142	synuclein alpha	Homo sapiens	158-162
22527697-2	2012	We have previously demonstrated that GRP-78 functions as a receptor for dentin matrix protein 1 (DMP1) and is required for DMP1-mediated calcium release; that it is a secreted protein and can bind to type I collagen and DMP1 extracellularly and aid in the nucleation of calcium phosphate.	calcium phosphate	270-287	heat shock protein family A (Hsp70) member 5	Homo sapiens	37-43
22703652-1	2012	INTRODUCTION: Mutations in the gene ALPL in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase, and the resulting increase in pyrophosphate (PP(i)) contributes to bone and tooth mineralization defects by inhibiting physiologic calcium-phosphate (P(i)) precipitation.	calcium phosphate	262-279	alkaline phosphatase, biomineralization associated	Homo sapiens	36-40
22504936-0	2012	Calcium phosphate nanocarriers dual-loaded with bovine serum albumin and ibuprofen: facile synthesis, sequential drug loading and sustained drug release.	calcium phosphate	0-17	albumin	Homo sapiens	55-68
22566464-1	2012	A dental composite containing amorphous calcium phosphate nanoparticles (NACP) was developed that released calcium (Ca) and phosphate (PO(4)) ions and possessed acid-neutralization capability.	calcium phosphate	40-57	synuclein alpha	Homo sapiens	73-77
22770669-2	2012	Herein we present the results of density functional theory (DFT) ab initio calculations of the NMR parameters for fluorapatite (FAp), a calcium orthophosphate mineral belonging to the apatite family, by using the GIPAW method (Pickard and Mauri, 2001).	calcium phosphate	136-158	fibroblast activation protein alpha	Homo sapiens	128-131
22640672-8	2012	Calcium phosphate enrichment on grade 4 titanium significantly increased the messenger RNA levels for alkaline phosphatase and osteocalcin.	calcium phosphate	0-17	bone gamma-carboxyglutamate protein 2	Mus musculus	127-138
22768855-2	2012	METHODS: After labeling of green fluorescent protein (GFP),  sh-NUDC-F was cloned into lentiviral vector pRRL-cPPT-CMV-X-PRE-SIN,  and the high-quality plasmid was transfected into 293T cells to produce lentiviral particles by the calcium phosphate method.	calcium phosphate	231-248	nuclear distribution C, dynein complex regulator	Homo sapiens	64-68
22419559-5	2012	Results demonstrated that both bovine serum albumin (BSA) and cytochrome C had a greater tendency to bind onto amorphous calcium phosphate (ACP) than crystalline HA, and the adsorption rate was correlated oppositely with the HA crystallinity.	calcium phosphate	121-138	albumin	Homo sapiens	38-51
22430263-4	2012	Besides calcium and calcitriol supplementation, she was the first patient with severe hypocalcemic cardiomyopathy to be given off-label recombinant human parathyroid hormone (PTH) because of an elevated serum calcium-phosphate product.	calcium phosphate	209-226	parathyroid hormone	Homo sapiens	154-173
22430263-4	2012	Besides calcium and calcitriol supplementation, she was the first patient with severe hypocalcemic cardiomyopathy to be given off-label recombinant human parathyroid hormone (PTH) because of an elevated serum calcium-phosphate product.	calcium phosphate	209-226	parathyroid hormone	Homo sapiens	175-178
22419559-5	2012	Results demonstrated that both bovine serum albumin (BSA) and cytochrome C had a greater tendency to bind onto amorphous calcium phosphate (ACP) than crystalline HA, and the adsorption rate was correlated oppositely with the HA crystallinity.	calcium phosphate	121-138	cytochrome c, somatic	Homo sapiens	62-74
22533508-1	2012	Fetuin-A is known for limiting the expansion and formation of hydroxyapatite crystals from calcium phosphate aggregates in circulation by forming a soluble fetuin-mineral complex.	calcium phosphate	91-108	alpha 2-HS glycoprotein	Homo sapiens	0-8
22533508-5	2012	In addition, purified native Hsp90 directly bound both amorphous calcium phosphate and hydroxyapatite and underwent conformational changes and oligomerization in the presence of excess calcium and phosphate.	calcium phosphate	65-82	heat shock protein 90 alpha family class A member 1	Homo sapiens	29-34
22533508-8	2012	This complex could also be probed in situ with fetuin-A suggesting the existence of calcium phosphate aggregates in this complex.	calcium phosphate	84-101	alpha 2-HS glycoprotein	Homo sapiens	47-55
23214203-12	2012	There is ambiguous data if FGF-23 only reflects disturbances in calcium-phosphate metabolism or if it exerts a detrimental effect itself by diminishing calcitriol synthesis, inducing cell proliferation or acting through low-affinity, Klotho-independent receptors in the heart and endothelium.	calcium phosphate	64-81	fibroblast growth factor 23	Homo sapiens	27-33
22410136-8	2012	Results from the ultrastructural analysis of the rabbit neointima through transmission electron microscopy and from the detection of calcium phosphate precipitates by specific histochemical techniques, suggested that OPN may be functionally important as a regulator of vascular calcification.	calcium phosphate	133-150	osteopontin	Oryctolagus cuniculus	217-220
22331375-1	2012	This study numerically studies absorption of human serum albumin (HSA) and basic protein lysozyme (LSZ) on crystallographic planes of octacalcium phosphate (OCP), an essential bioactive calcium phosphate.	calcium phosphate	138-155	albumin	Homo sapiens	51-70
22331375-1	2012	This study numerically studies absorption of human serum albumin (HSA) and basic protein lysozyme (LSZ) on crystallographic planes of octacalcium phosphate (OCP), an essential bioactive calcium phosphate.	calcium phosphate	138-155	lysozyme	Homo sapiens	89-97
22331375-1	2012	This study numerically studies absorption of human serum albumin (HSA) and basic protein lysozyme (LSZ) on crystallographic planes of octacalcium phosphate (OCP), an essential bioactive calcium phosphate.	calcium phosphate	138-155	lysozyme	Homo sapiens	99-102
22260994-5	2012	In vitro nucleation studies demonstrate a role for TRIP-1 in nucleating calcium phosphate polymorphs.	calcium phosphate	72-89	eukaryotic translation initiation factor 3 subunit I	Homo sapiens	51-57
22277992-4	2012	In the present study we investigated the osteogenic effects of calcium phosphate (CaP)-coated nanofiber mesh tube-mediated delivery of BMP-7 from a PRP matrix for the regeneration of critical sized segmental bone defects in a small animal model.	calcium phosphate	63-80	bone morphogenetic protein 7	Rattus norvegicus	135-140
22277992-4	2012	In the present study we investigated the osteogenic effects of calcium phosphate (CaP)-coated nanofiber mesh tube-mediated delivery of BMP-7 from a PRP matrix for the regeneration of critical sized segmental bone defects in a small animal model.	calcium phosphate	63-80	proline rich protein 2-like 1	Rattus norvegicus	148-151
22277992-4	2012	In the present study we investigated the osteogenic effects of calcium phosphate (CaP)-coated nanofiber mesh tube-mediated delivery of BMP-7 from a PRP matrix for the regeneration of critical sized segmental bone defects in a small animal model.	calcium phosphate	82-85	bone morphogenetic protein 7	Rattus norvegicus	135-140
22277992-4	2012	In the present study we investigated the osteogenic effects of calcium phosphate (CaP)-coated nanofiber mesh tube-mediated delivery of BMP-7 from a PRP matrix for the regeneration of critical sized segmental bone defects in a small animal model.	calcium phosphate	82-85	proline rich protein 2-like 1	Rattus norvegicus	148-151
22410136-10	2012	CONCLUSIONS: This study establishes the in vivo role of OPN in the intima of the aorta regulating calcium phosphate precipitate deposition in response to oxidative stress.	calcium phosphate	98-115	osteopontin	Oryctolagus cuniculus	56-59
23055614-2	2012	In this study, we engaged computer-aided methodology in combination with molecular docking and pharmacophore filtering to identify chemical compounds that can increase the synthesis of vitamin D receptor (VDR) since its lower expression leads to calcium phosphate metabolic disorders in Chronic Kidney Disease.	calcium phosphate	246-263	vitamin D receptor	Homo sapiens	185-203
23055614-2	2012	In this study, we engaged computer-aided methodology in combination with molecular docking and pharmacophore filtering to identify chemical compounds that can increase the synthesis of vitamin D receptor (VDR) since its lower expression leads to calcium phosphate metabolic disorders in Chronic Kidney Disease.	calcium phosphate	246-263	vitamin D receptor	Homo sapiens	205-208
23235437-5	2012	The present study explored, whether SPAK participates in the regulation of calcium-phosphate homeostasis.	calcium phosphate	75-92	serine/threonine kinase 39	Mus musculus	36-40
23091492-10	2012	Both LPS and RANKL stimulated macrophages to form osteoclast-like TRAP positive cells, which resorbed calcium phosphate substrates.	calcium phosphate	102-119	TNF superfamily member 11	Homo sapiens	13-18
22777106-1	2012	BACKGROUND: We chose to study polymorphisms of vitamin D receptor gene (VDR) and parathyroid hormone genes (PTH), whose protein products significantly affect calciumphosphate metabolism in kidneys and are implicated in the pathogenesis of diabetes, which may also involve kidney damage.	calcium phosphate	158-174	vitamin D receptor	Homo sapiens	47-65
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	calcium phosphate	239-256	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
22777106-1	2012	BACKGROUND: We chose to study polymorphisms of vitamin D receptor gene (VDR) and parathyroid hormone genes (PTH), whose protein products significantly affect calciumphosphate metabolism in kidneys and are implicated in the pathogenesis of diabetes, which may also involve kidney damage.	calcium phosphate	158-174	vitamin D receptor	Homo sapiens	72-75
22777106-1	2012	BACKGROUND: We chose to study polymorphisms of vitamin D receptor gene (VDR) and parathyroid hormone genes (PTH), whose protein products significantly affect calciumphosphate metabolism in kidneys and are implicated in the pathogenesis of diabetes, which may also involve kidney damage.	calcium phosphate	158-174	parathyroid hormone	Homo sapiens	81-100
21889796-3	2011	Due to the high surface area of nBG and increased reactivity, calcium phosphate formation was immediately detected within as processed DC-nGB hybrid gel scaffolds.	calcium phosphate	62-79	neuroglobin	Homo sapiens	138-141
23750431-9	2012	CONCLUSIONS: In peritoneal dialysis patients along with increment of IPTH concentrations and enchancement of calcium-phosphate imbalance, significantly rise concentrations of calcification markers such as: osteocalcin (OC), osteopontin (OPN), as well as fibroblast growth factor-23 (FGF-23).	calcium phosphate	109-126	bone gamma-carboxyglutamate protein	Homo sapiens	206-217
22007998-7	2011	Interestingly, additional preliminary results still indicate a promotive effect of phosvitin-containing remnant films on calcium phosphate deposition.	calcium phosphate	121-138	casein kinase 2 beta	Homo sapiens	83-92
22243235-7	2011	However, in contrast to the findings for low IS, where both P173 and P148 stabilize initially formed amorphous calcium phosphate (ACP) nanoparticles for >1 d, elongated hydroxyapatite crystals were observed after 24 h using P148 at high IS, unlike that seen with P173.	calcium phosphate	111-128	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	60-64
21418332-0	2011	The effect of combined delivery of recombinant human bone morphogenetic protein-2 and recombinant human vascular endothelial growth factor 165 from biomimetic calcium-phosphate-coated implants on osseointegration.	calcium phosphate	159-176	vascular endothelial growth factor A	Homo sapiens	104-138
21963155-6	2011	In co-culture of bone marrow adipocytes and osteoclast precursors with TNF-alpha, the number of TRAP-positive multinuclear cells and resorption cavity formations of calcium phosphate film were increased.	calcium phosphate	165-182	tumor necrosis factor	Homo sapiens	71-80
21983022-4	2011	In the present study, this property was conferred by coating DBB with a layer of calcium phosphate into which bone morphogenetic protein 2 (BMP-2) was incorporated.	calcium phosphate	81-98	bone morphogenetic protein 2	Bos taurus	110-138
21983022-4	2011	In the present study, this property was conferred by coating DBB with a layer of calcium phosphate into which bone morphogenetic protein 2 (BMP-2) was incorporated.	calcium phosphate	81-98	bone morphogenetic protein 2	Bos taurus	140-145
22263272-2	2011	NS1 gene was ligated with pBABE-puro to construct the recombinant retroviral expression plasmid pBABE-NS1, which was cotransfected into 293FT packaging cells with PIK packaging plasmid by calcium phosphate co-precipitation.	calcium phosphate	188-205	influenza virus NS1A binding protein	Homo sapiens	0-3
21702756-0	2011	Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic protein-2 using block-type macroporous biphasic calcium phosphate in orthotopic and ectopic rat models.	calcium phosphate	143-160	bone morphogenetic protein 2	Homo sapiens	76-104
21702756-1	2011	BACKGROUND AND OBJECTIVE: The potential of the Escherichia coli-expressed recombinant human bone morphogenetic protein-2 (ErhBMP-2) to support new bone formation/maturation using a block-type of macroporous biphasic calcium phosphate (bMBCP) carrier was evaluated in an orthotopic and ectopic rat model.	calcium phosphate	216-233	bone morphogenetic protein 2	Homo sapiens	92-120
21778669-7	2011	These results suggest that coating artificial bone implants with trehalose could limit the binding of bFGF to calcium phosphate.	calcium phosphate	110-127	fibroblast growth factor 2	Mus musculus	102-106
22002921-5	2011	Cell number, prostaglandin E(2) (PGE(2) ) synthesis and osteopontin (OPN) mRNA expression were elevated on calcium phosphate-decorated scaffolds relative to PLGA controls, while mRNA expression of osteocalcin (OCN), bone sialoprotein and bone morphogenetic protein (BMP)-4 were suppressed.	calcium phosphate	107-124	secreted phosphoprotein 1	Homo sapiens	56-67
21733911-0	2011	The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation.	calcium phosphate	51-68	fibroblast growth factor 23	Homo sapiens	17-44
22002921-5	2011	Cell number, prostaglandin E(2) (PGE(2) ) synthesis and osteopontin (OPN) mRNA expression were elevated on calcium phosphate-decorated scaffolds relative to PLGA controls, while mRNA expression of osteocalcin (OCN), bone sialoprotein and bone morphogenetic protein (BMP)-4 were suppressed.	calcium phosphate	107-124	secreted phosphoprotein 1	Homo sapiens	69-72
22002921-5	2011	Cell number, prostaglandin E(2) (PGE(2) ) synthesis and osteopontin (OPN) mRNA expression were elevated on calcium phosphate-decorated scaffolds relative to PLGA controls, while mRNA expression of osteocalcin (OCN), bone sialoprotein and bone morphogenetic protein (BMP)-4 were suppressed.	calcium phosphate	107-124	bone gamma-carboxyglutamate protein	Homo sapiens	197-208
22002921-5	2011	Cell number, prostaglandin E(2) (PGE(2) ) synthesis and osteopontin (OPN) mRNA expression were elevated on calcium phosphate-decorated scaffolds relative to PLGA controls, while mRNA expression of osteocalcin (OCN), bone sialoprotein and bone morphogenetic protein (BMP)-4 were suppressed.	calcium phosphate	107-124	bone gamma-carboxyglutamate protein	Homo sapiens	210-213
22002921-5	2011	Cell number, prostaglandin E(2) (PGE(2) ) synthesis and osteopontin (OPN) mRNA expression were elevated on calcium phosphate-decorated scaffolds relative to PLGA controls, while mRNA expression of osteocalcin (OCN), bone sialoprotein and bone morphogenetic protein (BMP)-4 were suppressed.	calcium phosphate	107-124	bone morphogenetic protein 4	Homo sapiens	238-272
21569871-6	2011	The aim of this study was to assess the ectopic bone forming capability of various calcium phosphate compounds when used in conjunction with a hydrogel as the carrier for BMP-2.	calcium phosphate	83-100	bone morphogenetic protein 2	Rattus norvegicus	171-176
21773992-3	2011	We aimed to study the effects of PTH-replacement therapy (PTH-RT) on calcium-phosphate homeostasis and BMD.	calcium phosphate	69-86	parathyroid hormone	Homo sapiens	33-36
21773992-3	2011	We aimed to study the effects of PTH-replacement therapy (PTH-RT) on calcium-phosphate homeostasis and BMD.	calcium phosphate	69-86	parathyroid hormone	Homo sapiens	58-61
21636885-2	2011	The BMP-2 gene-Fn-apatite composite layer was coated on the scaffold using a supersaturated calcium phosphate solution supplemented with BMP-2 DNA and Fn.	calcium phosphate	92-109	bone morphogenetic protein 2	Rattus norvegicus	4-9
21706042-4	2011	METHODS: Expression plasmids encoding C5aR and its mutants were prepared using PCR and site-directed mutagenesis and were used to transfect HEK 293T cells using calcium phosphate.	calcium phosphate	161-178	complement C5a receptor 1	Homo sapiens	38-42
21281745-5	2011	Down-regulation of pro-inflammatory cytokine gene expression (confirmed at the protein level for TNFalpha and CCL5), may thus facilitate the enhanced bone wound healing and osseointegration observed clinically with nanoscale calcium phosphate-modified implant surfaces.	calcium phosphate	225-242	tumor necrosis factor	Mus musculus	97-105
21659498-9	2011	Coincubation with OPG, the decoy receptor for RANKL, attenuated osteogenic differentiation of VSMCs and was independent of a high calcium-phosphate milieu.	calcium phosphate	130-147	TNF receptor superfamily member 11b	Homo sapiens	18-21
21514655-2	2011	The objectives of this study were to synthesize novel nanoparticles of amorphous calcium phosphate (NACP), develop NACP nanocomposite with calcium (Ca) and phosphate (PO(4)) ion release to combat caries, and investigate the effects of NACP filler level and glass co-filler reinforcement on composite properties.	calcium phosphate	81-98	synuclein alpha	Homo sapiens	100-104
21514655-12	2011	The new NACP nanocomposites had strengths that were 2-fold those of previous calcium phosphate composites and resin-modified glass ionomer control.	calcium phosphate	77-94	synuclein alpha	Homo sapiens	8-12
21985975-2	2011	PTH plays a central role in regulating calcium-phosphate metabolism and its production increases in response to low serum calcium levels.	calcium phosphate	39-56	parathyroid hormone	Homo sapiens	0-3
21587153-7	2011	The transfection of the recombinant plasmid encoding RBD to the cells was then performed using a calcium phosphate transfection method with some modifications.	calcium phosphate	97-114	calcium voltage-gated channel subunit alpha1 D	Rattus norvegicus	53-56
21281745-5	2011	Down-regulation of pro-inflammatory cytokine gene expression (confirmed at the protein level for TNFalpha and CCL5), may thus facilitate the enhanced bone wound healing and osseointegration observed clinically with nanoscale calcium phosphate-modified implant surfaces.	calcium phosphate	225-242	chemokine (C-C motif) ligand 5	Mus musculus	110-114
21740754-7	2011	Ultrasonic destruction of microbubbles during calcium phosphate precipitation gene transfection enhanced beta-galactosidase activity nearly 8-fold compared with calcium phosphate precipitation gene transfection alone ((111.35 +- 11.21) U/g protein vs. (14.13 +- 2.58) U/g protein, P < 0.01).	calcium phosphate	46-63	galactosidase beta 1	Homo sapiens	105-123
21235414-4	2011	For osteogenesis gelatin/beta-tricalcium phosphate (beta-TCP) scaffolds with incorporated controlled-release bone morphogenetic protein-2 (BMP-2) as third-generation biomaterials were recently developed.	calcium phosphate	52-60	bone morphogenetic protein 2	Homo sapiens	109-137
21432993-4	2011	In this study, PTH was incorporated into a biomimetic calcium phosphate (CaP) coating via a coprecipitation process in a modified simulated body fluid (m-SBF).	calcium phosphate	54-71	parathyroid hormone	Mus musculus	15-18
21406666-3	2011	HYPOTHESIS: Delivery of TGF-beta(3) in an injectable calcium-phosphate matrix to the healing tendon-bone interface after rotator cuff repair will result in increased attachment strength secondary to improved bone formation and collagen organization and reduced scar formation of the healing enthesis.	calcium phosphate	53-70	transforming growth factor, beta 3	Rattus norvegicus	24-35
21406666-12	2011	RESULTS: There was significantly greater load to failure of the Ca-P matrix + TGF-beta(3) group compared with matrix alone or untreated controls at 4 weeks postoperatively (P = .04).	calcium phosphate	64-68	transforming growth factor, beta 3	Rattus norvegicus	78-89
21406666-19	2011	CLINICAL RELEVANCE: The delivery of TGF-beta(3) with an injectable Ca-P matrix at the supraspinatus tendon footprint has promise to improve healing after soft tissue repair.	calcium phosphate	67-71	transforming growth factor, beta 3	Rattus norvegicus	36-47
21288570-4	2011	Small GTPase RhoA and phosphatase and tensin homolog (PTEN) were more activated in cells grown on the surface of calcium phosphate apatite than on tissue culture plate.	calcium phosphate	113-130	ras homolog family member A	Homo sapiens	13-17
21288570-4	2011	Small GTPase RhoA and phosphatase and tensin homolog (PTEN) were more activated in cells grown on the surface of calcium phosphate apatite than on tissue culture plate.	calcium phosphate	113-130	phosphatase and tensin homolog	Homo sapiens	54-58
21288570-5	2011	Specific inhibition of RhoA and PTEN induced the cells on calcium phosphate apatite surface to proliferate at a similar rate as cells on tissue culture plate surface.	calcium phosphate	58-75	ras homolog family member A	Homo sapiens	23-27
21288570-5	2011	Specific inhibition of RhoA and PTEN induced the cells on calcium phosphate apatite surface to proliferate at a similar rate as cells on tissue culture plate surface.	calcium phosphate	58-75	phosphatase and tensin homolog	Homo sapiens	32-36
21288570-7	2011	Present results indicate that physical property of calcium phosphate crystals that impede cell proliferation may be surmounted by the inhibition of the RhoA/ROCK/PTEN pathway to rescue delayed proliferation of osteoblasts on the calcium phosphate apatite surface.	calcium phosphate	51-68	ras homolog family member A	Homo sapiens	152-156
21288570-7	2011	Present results indicate that physical property of calcium phosphate crystals that impede cell proliferation may be surmounted by the inhibition of the RhoA/ROCK/PTEN pathway to rescue delayed proliferation of osteoblasts on the calcium phosphate apatite surface.	calcium phosphate	51-68	phosphatase and tensin homolog	Homo sapiens	162-166
21288570-7	2011	Present results indicate that physical property of calcium phosphate crystals that impede cell proliferation may be surmounted by the inhibition of the RhoA/ROCK/PTEN pathway to rescue delayed proliferation of osteoblasts on the calcium phosphate apatite surface.	calcium phosphate	229-246	ras homolog family member A	Homo sapiens	152-156
21288570-7	2011	Present results indicate that physical property of calcium phosphate crystals that impede cell proliferation may be surmounted by the inhibition of the RhoA/ROCK/PTEN pathway to rescue delayed proliferation of osteoblasts on the calcium phosphate apatite surface.	calcium phosphate	229-246	phosphatase and tensin homolog	Homo sapiens	162-166
21288570-9	2011	Inhibition of the RhoA/ROCK/PTEN intracellular signaling pathway is expected to enhance cell activity to promote and accelerate bone regeneration on the calcium phosphate apatite surface.	calcium phosphate	153-170	ras homolog family member A	Homo sapiens	18-22
21288570-9	2011	Inhibition of the RhoA/ROCK/PTEN intracellular signaling pathway is expected to enhance cell activity to promote and accelerate bone regeneration on the calcium phosphate apatite surface.	calcium phosphate	153-170	phosphatase and tensin homolog	Homo sapiens	28-32
20678131-1	2011	OBJECTIVES: To study the effects of the bone morphogenetic protein-2 (BMP-2)/fibroblast growth factor (bFGF)-loaded porous calcium phosphate cement (CPC) on the repair of bone defects around dental implants.	calcium phosphate	123-140	bone morphogenetic protein 2	Canis lupus familiaris	40-68
21239500-6	2011	In vitro nucleation experiments under physiological concentrations of calcium and phosphate ions indicated that GRP-78 can induce the formation of calcium phosphate polymorphs by itself, when bound to immobilized type I collagen and on demineralized collagen wafers.	calcium phosphate	147-164	heat shock protein 5	Mus musculus	112-118
20977950-10	2011	Finally, the surfaces" bone-bonding ability was investigated by examination of their ability to form calcium phosphate crystals in a simulated body fluid, with a-CNx depositing most calcium phosphate after 21 days of incubation.	calcium phosphate	101-118	calnexin	Homo sapiens	162-165
20977950-10	2011	Finally, the surfaces" bone-bonding ability was investigated by examination of their ability to form calcium phosphate crystals in a simulated body fluid, with a-CNx depositing most calcium phosphate after 21 days of incubation.	calcium phosphate	182-199	calnexin	Homo sapiens	162-165
22268059-3	2011	Judging from secretory activity of the cell culture (osteocalcin, alkaline phosphatase), stromal stem cells directly interacting with calcium phosphate discs have advantage in manifestation of osteoblast-like functional activity in comparison with cells cultured on plastic.	calcium phosphate	134-151	bone gamma-carboxyglutamate protein	Homo sapiens	53-64
20678131-1	2011	OBJECTIVES: To study the effects of the bone morphogenetic protein-2 (BMP-2)/fibroblast growth factor (bFGF)-loaded porous calcium phosphate cement (CPC) on the repair of bone defects around dental implants.	calcium phosphate	123-140	bone morphogenetic protein 2	Canis lupus familiaris	70-75
20678131-1	2011	OBJECTIVES: To study the effects of the bone morphogenetic protein-2 (BMP-2)/fibroblast growth factor (bFGF)-loaded porous calcium phosphate cement (CPC) on the repair of bone defects around dental implants.	calcium phosphate	123-140	fibroblast growth factor 2	Canis lupus familiaris	103-107
20944546-8	2011	Thus, our results suggest that BMP-2 and OPN are induced by calcium phosphate nanocrystals, rather than soluble phosphate.	calcium phosphate	60-77	bone morphogenetic protein 2	Mus musculus	31-36
21074619-7	2011	Although phosphorylation has a subtle effect on the higher-order assembly of full-length amelogenin, native phosphorylated P173 was found to stabilize amorphous calcium phosphate for extended periods of time, in sharp contrast to previous findings using non-phosphorylated rP172.	calcium phosphate	161-178	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	123-127
20944546-8	2011	Thus, our results suggest that BMP-2 and OPN are induced by calcium phosphate nanocrystals, rather than soluble phosphate.	calcium phosphate	60-77	secreted phosphoprotein 1	Mus musculus	41-44
22238727-0	2011	Preliminary clinical reports of a novel night-guard tooth bleaching technique modified by casein phosphopeptide-amorphous calcium phosphate (CCP-ACP).	calcium phosphate	122-139	CPAT1	Homo sapiens	145-148
21278777-3	2011	highlights an important and novel role for calcium phosphate nanocrystals, produced in a high-phosphate environment, in rapidly driving calcification of vascular smooth muscle cells via enhanced production of bone morphogenetic protein-2.	calcium phosphate	43-60	bone morphogenetic protein 2	Homo sapiens	209-237
21986387-4	2011	Traditional care addresses the calcium-phosphate-PTH axis: minimizing calcium intake, calcimimetics, cautious vitamin D analogs, strict phosphate control, and surgical parathyroidectomy if necessary.	calcium phosphate	31-48	parathyroid hormone	Homo sapiens	49-52
21494013-1	2011	The aim of this study was to evaluate the effects of maxillary sinus floor elevation by a tissue-engineered bone complex with recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous calcium phosphate cement (CPC) scaffold and bone marrow stromal cells (bMSCs) in rabbits.	calcium phosphate	197-214	bone morphogenetic protein 2	Homo sapiens	144-172
21234310-1	2010	Fibroblast growth factor- (FGF-)23 is a recently discovered regulator of calcium-phosphate metabolism.	calcium phosphate	73-90	fibroblast growth factor 23	Homo sapiens	0-34
22335012-6	2011	The current knowledge on FGF-23 has lead to suspect that in the nearest future it may serve as sensitive marker of early calcium-phosphate disturbances in patients with CKD.	calcium phosphate	121-138	fibroblast growth factor 23	Homo sapiens	25-31
22164160-1	2011	Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls.	calcium phosphate	55-72	fibroblast growth factor 23	Homo sapiens	7-13
21948421-4	2011	Specific proteins that could nucleate a calcium phosphate shell under physiologic conditions have been identified as part of their structure, including elongation factor Tu (EF-Tu) and fetuin-A.	calcium phosphate	40-57	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	152-172
21948421-4	2011	Specific proteins that could nucleate a calcium phosphate shell under physiologic conditions have been identified as part of their structure, including elongation factor Tu (EF-Tu) and fetuin-A.	calcium phosphate	40-57	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	174-179
21948421-4	2011	Specific proteins that could nucleate a calcium phosphate shell under physiologic conditions have been identified as part of their structure, including elongation factor Tu (EF-Tu) and fetuin-A.	calcium phosphate	40-57	alpha 2-HS glycoprotein	Homo sapiens	185-193
21789179-3	2011	Absence of alpha-casein protein significantly curtails secretion of other milk proteins and calcium-phosphate, suggesting a role for alpha-casein in the establishment of casein micelles.	calcium phosphate	92-109	casein alpha s1	Mus musculus	11-23
22010474-5	2011	In the 2nd part of this work, regulatory activity in the calcium-phosphate homeostasis in different stages of chronic kidney disease (CKD) with special attention to increased synthesis of FGF-23 in the course of declined glomerular filtration rate were elucidated.	calcium phosphate	57-74	fibroblast growth factor 23	Homo sapiens	188-194
20966534-2	2010	In this study, a fibroblast growth factor-2 (FGF-2)-hydroxyapatite (HAp) composite layer (FHAp layer) was formed on the surfaces of ethylene-vinyl alcohol copolymer (EVOH) specimens using a coating process in a supersaturated calcium phosphate solution supplemented with FGF-2.	calcium phosphate	226-243	fibroblast growth factor 2	Rattus norvegicus	17-43
20966534-2	2010	In this study, a fibroblast growth factor-2 (FGF-2)-hydroxyapatite (HAp) composite layer (FHAp layer) was formed on the surfaces of ethylene-vinyl alcohol copolymer (EVOH) specimens using a coating process in a supersaturated calcium phosphate solution supplemented with FGF-2.	calcium phosphate	226-243	fibroblast growth factor 2	Rattus norvegicus	45-50
20952466-8	2010	After treatment with calcitriol for 6 months, serum miR-146a level of SLE patients increased significantly (p < 0.001), and its change inversely correlated with the level of calcium-phosphate product (r = -0.466, p = 0.003).	calcium phosphate	177-194	microRNA 146a	Homo sapiens	52-60
21076415-2	2010	Serum is a metastable solution from which calcium phosphate precipitates in the presence of calcifiable templates such as collagen, elastin and cell debris.	calcium phosphate	42-59	elastin	Homo sapiens	132-139
20583917-10	2010	Resorption of calcium phosphate significantly increased in the H(2)S-induced TRAP-positive cells cultured on plates coated with calcium phosphate apatite (P <0.01).	calcium phosphate	14-31	acid phosphatase 5, tartrate resistant	Mus musculus	77-81
21037382-7	2010	In the process of degeneration of elastin polypentapeptide structure in elastin can be easily conbined to Ca(2+), elastin-Ca(2+) complex is neutralized by PO4(2-) and calcium phosphate is accumulated in degenerated elastin.	calcium phosphate	167-184	elastin	Homo sapiens	34-41
21037382-7	2010	In the process of degeneration of elastin polypentapeptide structure in elastin can be easily conbined to Ca(2+), elastin-Ca(2+) complex is neutralized by PO4(2-) and calcium phosphate is accumulated in degenerated elastin.	calcium phosphate	167-184	elastin	Homo sapiens	72-79
21037382-7	2010	In the process of degeneration of elastin polypentapeptide structure in elastin can be easily conbined to Ca(2+), elastin-Ca(2+) complex is neutralized by PO4(2-) and calcium phosphate is accumulated in degenerated elastin.	calcium phosphate	167-184	elastin	Homo sapiens	72-79
21037382-7	2010	In the process of degeneration of elastin polypentapeptide structure in elastin can be easily conbined to Ca(2+), elastin-Ca(2+) complex is neutralized by PO4(2-) and calcium phosphate is accumulated in degenerated elastin.	calcium phosphate	167-184	elastin	Homo sapiens	72-79
20591941-7	2010	Compared with 24-h urine from the wild-type mice, that of THP-null mice is supersaturated with brushite (calcium phosphate), a stone precursor, and has reduced urinary excretion of citrate, a stone inhibitor.	calcium phosphate	105-122	uromodulin	Mus musculus	58-61
20368306-6	2010	To demonstrate functional relevance, MGP was silenced in HPMC by siRNA transfection and calcium phosphate matrix deposition measured by o-cresolphthalein complexone method and von Kossa staining.	calcium phosphate	88-105	matrix Gla protein	Homo sapiens	37-40
20731414-1	2010	Human salivary statherin inhibits both primary and secondary calcium phosphate precipitation and, upon binding to hydroxyapatite, associates with a variety of oral bacteria.	calcium phosphate	61-78	statherin	Homo sapiens	15-24
20731414-9	2010	Whole saliva protease activities separated the charged N-terminus from the hydrophobic C-terminus, negatively impacting on full length statherin functions comprising enamel lubrication and inhibition of primary calcium phosphate precipitation.	calcium phosphate	211-228	statherin	Homo sapiens	135-144
20683124-0	2010	Enhanced bone forming ability of SLA-treated Ti coated with a calcium phosphate thin film formed by e-beam evaporation.	calcium phosphate	62-79	Src like adaptor	Homo sapiens	33-36
20541046-8	2010	Transgenic bone marrow cultures treated with RANKL and M-CSF showed greater osteoclast formation; however, osteoclast activity as assessed by resorption of a calcium phosphate substrate was decreased in transgenic cultures.	calcium phosphate	158-175	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	45-50
20189819-0	2010	Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model.	calcium phosphate	59-76	bone morphogenetic protein 7	Mus musculus	100-105
20189819-0	2010	Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model.	calcium phosphate	59-76	vascular endothelial growth factor A	Mus musculus	107-111
20189819-2	2010	The aim of the present study was to evaluate whether bone morphogenetic protein (BMP-7) promoted osteoinduction could be enhanced by combining it with vascular endothelial growth factor (VEGF) or MSCs in highly porous biphasic calcium phosphate (BCP) ceramics.	calcium phosphate	227-244	bone morphogenetic protein 7	Mus musculus	81-86
20623177-4	2010	High heat-treatment temperatures enhance the thermal decomposition of HAp into other calcium phosphate compounds, and the sintering of particles into micrometer ball-like structures.	calcium phosphate	85-102	reticulon 3	Homo sapiens	70-73
23662086-0	2010	Remineralization of eroded enamel by a NaF rinse containing a novel calcium phosphate agent in an in situ model: a pilot study.	calcium phosphate	68-85	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
20683124-1	2010	With an electron-beam evaporation process, a calcium phosphate (Ca-P) thin film of approximately 500 nm thick was deposited on sand blasted with large grits and acid etched (SLA) Ti without changing the typical morphology of the SLA surface.	calcium phosphate	45-62	Src like adaptor	Homo sapiens	174-177
20683124-1	2010	With an electron-beam evaporation process, a calcium phosphate (Ca-P) thin film of approximately 500 nm thick was deposited on sand blasted with large grits and acid etched (SLA) Ti without changing the typical morphology of the SLA surface.	calcium phosphate	64-68	Src like adaptor	Homo sapiens	174-177
20683124-4	2010	The Saos-2 cell was more attached on the coated surface, and the in vivo evaluation was that the Ca-P deposited SLA implant greatly improved the new bone formation ability.	calcium phosphate	97-101	Src like adaptor	Homo sapiens	112-115
20464457-0	2010	Mg2+ substituted calcium phosphate nano particles synthesis for non viral gene delivery application.	calcium phosphate	17-34	mucin 7, secreted	Homo sapiens	0-3
20610874-2	2010	CS-B, CS-E, low molecular weight CS-E, synthetic chondroitin polysulfate (CPS) and heparin significantly inhibited the formation of tartrate-resistant acid phosphatase-positive multinuclear cells and pit formation on calcium phosphate (CaP)-coated plates.	calcium phosphate	217-234	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	0-4
20610874-2	2010	CS-B, CS-E, low molecular weight CS-E, synthetic chondroitin polysulfate (CPS) and heparin significantly inhibited the formation of tartrate-resistant acid phosphatase-positive multinuclear cells and pit formation on calcium phosphate (CaP)-coated plates.	calcium phosphate	217-234	cystathionase (cystathionine gamma-lyase)	Mus musculus	33-37
20610874-2	2010	CS-B, CS-E, low molecular weight CS-E, synthetic chondroitin polysulfate (CPS) and heparin significantly inhibited the formation of tartrate-resistant acid phosphatase-positive multinuclear cells and pit formation on calcium phosphate (CaP)-coated plates.	calcium phosphate	236-239	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	0-4
20610874-2	2010	CS-B, CS-E, low molecular weight CS-E, synthetic chondroitin polysulfate (CPS) and heparin significantly inhibited the formation of tartrate-resistant acid phosphatase-positive multinuclear cells and pit formation on calcium phosphate (CaP)-coated plates.	calcium phosphate	236-239	cystathionase (cystathionine gamma-lyase)	Mus musculus	33-37
20045091-3	2010	Hydroxyapatite ceramic buttons (HAP-CBs) were coated with FGF-2 by precipitation in supersaturated calcium phosphate solution.	calcium phosphate	99-116	fibroblast growth factor 2	Rattus norvegicus	58-63
20306162-0	2010	Calcium phosphate cement with BMP-2-loaded gelatin microspheres enhances bone healing in osteoporosis: a pilot study.	calcium phosphate	0-17	bone morphogenetic protein 2	Capra hircus	30-35
20376517-9	2010	Factors affecting log(10)FGF-23 included the serum calcium phosphate product (beta = 0.603) and K (t)/V (integrated fractional clearance expressed per dialysis, beta = -0.244).	calcium phosphate	51-68	fibroblast growth factor 23	Homo sapiens	25-31
20438109-8	2010	Therefore, independent of conformations, the BSP nucleating motif is more likely to help nucleate an amorphous calcium phosphate cluster, which ultimately converts to crystalline hydroxyapatite.	calcium phosphate	111-128	integrin binding sialoprotein	Homo sapiens	45-48
20392613-0	2010	Influence of surface topography on osteoblast response to fibronectin coated calcium phosphate thin films.	calcium phosphate	77-94	fibronectin 1	Homo sapiens	58-69
20376517-12	2010	The only factors affecting log(10)FGF-23 were the serum calcium phosphate product and K (t)/V.	calcium phosphate	56-73	fibroblast growth factor 23	Homo sapiens	34-40
20035875-3	2010	Here we follow calcium phosphate mineralization on protein fibers self-assembled in vitro from solutions of fibronectin, elastin and their mixture.	calcium phosphate	15-32	fibronectin 1	Homo sapiens	108-119
20359372-12	2010	Treatment with calcium phosphate nanoparticles at concentrations of 10-100 microM didn"t significantly change either the progesterone or estradiol levels in culture fluid, and the expression levels of mRNAs encoding P450scc, P450arom and StAR after 48 h and 72 h period of treatment.	calcium phosphate	15-32	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	216-223
20359372-12	2010	Treatment with calcium phosphate nanoparticles at concentrations of 10-100 microM didn"t significantly change either the progesterone or estradiol levels in culture fluid, and the expression levels of mRNAs encoding P450scc, P450arom and StAR after 48 h and 72 h period of treatment.	calcium phosphate	15-32	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	225-233
20132485-3	2010	The present study characterizes a novel cellular model for the study of alpha-syn aggregation, incorporating nucleation-dependent aggregation and a new function for calcium phosphate precipitation.	calcium phosphate	165-182	synuclein alpha	Homo sapiens	72-81
20044134-0	2010	The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF(165).	calcium phosphate	26-43	vascular endothelial growth factor A	Mus musculus	148-152
20035875-3	2010	Here we follow calcium phosphate mineralization on protein fibers self-assembled in vitro from solutions of fibronectin, elastin and their mixture.	calcium phosphate	15-32	elastin	Homo sapiens	121-128
20035875-7	2010	In the presence of fibronectin, longer exposure in the mineral solution leads to the formation of amorphous calcium phosphate particles templated along the self-assembled fibers, while elastin fibers only collect calcium without any mineral observed during early stage.	calcium phosphate	108-125	fibronectin 1	Homo sapiens	19-30
20141417-9	2010	Some of the duplicated copies of SPARC/osteonectin became secretory Cabinding phosphoproteins (SCPPs) performing a central role in mineralization by regulating the calcium phosphate concentration.	calcium phosphate	164-181	secreted protein acidic and cysteine rich	Homo sapiens	33-38
19703596-2	2010	The surface of a biphasic calcium phosphate ceramic was functionalized with a recombinant protein spanning the fragments of fibronectin module III7-10 and extracellular domains 1 and 2 of cadherin 11 (rFN/CDH) using a dimethyl-3,3"-dithiobispropionimidate cross-linking method.	calcium phosphate	26-43	fibronectin 1	Homo sapiens	124-135
19795094-0	2010	Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism.	calcium phosphate	46-63	POU class 1 homeobox 1	Rattus norvegicus	22-27
19795094-3	2010	In the present study, we investigated the effects of the transgenic overexpression of Pit-1 in Wistar male rats on calcium phosphate and bone metabolism.	calcium phosphate	115-132	POU class 1 homeobox 1	Rattus norvegicus	86-91
19795094-10	2010	In conclusion, transgenic Pit-1 overexpression in rats affected bone and calcium phosphate metabolism.	calcium phosphate	73-90	POU class 1 homeobox 1	Rattus norvegicus	26-31
20178096-0	2010	VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo.	calcium phosphate	23-40	vascular endothelial growth factor A	Mus musculus	0-4
20178096-4	2010	We hypothesized that a continuous delivery of low concentrations of VEGF from calcium phosphate ceramics may increase the efficacy of VEGF administration.VEGF was co-precipitated onto biphasic calcium phosphate (BCP) ceramics to achieve a sustained release of the growth factor.	calcium phosphate	78-95	vascular endothelial growth factor A	Mus musculus	68-72
20178096-4	2010	We hypothesized that a continuous delivery of low concentrations of VEGF from calcium phosphate ceramics may increase the efficacy of VEGF administration.VEGF was co-precipitated onto biphasic calcium phosphate (BCP) ceramics to achieve a sustained release of the growth factor.	calcium phosphate	78-95	vascular endothelial growth factor A	Mus musculus	134-138
20178096-4	2010	We hypothesized that a continuous delivery of low concentrations of VEGF from calcium phosphate ceramics may increase the efficacy of VEGF administration.VEGF was co-precipitated onto biphasic calcium phosphate (BCP) ceramics to achieve a sustained release of the growth factor.	calcium phosphate	78-95	vascular endothelial growth factor A	Mus musculus	134-138
20178096-4	2010	We hypothesized that a continuous delivery of low concentrations of VEGF from calcium phosphate ceramics may increase the efficacy of VEGF administration.VEGF was co-precipitated onto biphasic calcium phosphate (BCP) ceramics to achieve a sustained release of the growth factor.	calcium phosphate	193-210	vascular endothelial growth factor A	Mus musculus	68-72
19931903-3	2010	The micro/ma-MCP scaffolds with porosities varied from 52 to 78% showed well interconnected and open macropores with the sizes of 400-500 microm, and degradation of the scaffolds was significantly enhanced in Tris-HCl solution compared with macroporous MCP (ma-MCP) and corresponding calcium phosphate cement (CPC) scaffolds.	calcium phosphate	284-301	CD46 molecule	Homo sapiens	13-16
18985777-5	2009	Indices of osteogenic differentiation including the expression of osteopontin and alkaline phosphatase (ALP) were consistently higher in the nontreated and thin Ca-P-treated scaffolds when compared with thick Ca-P-treated scaffolds at 2 weeks.	calcium phosphate	161-165	secreted phosphoprotein 1	Homo sapiens	66-77
20662476-0	2010	[Calcitonin and his role in regulation of calcium-phosphate metabolism].	calcium phosphate	42-59	calcitonin related polypeptide alpha	Homo sapiens	1-11
18560768-1	2009	A novel, porous triphasic calcium phosphate composed of nonresorbable hydroxyapatite (HAp) and resorbable tricalcium phosphate (alpha- and beta-TCP) has been synthesized hydrothermally at a relatively low temperature.	calcium phosphate	26-43	retinoic acid receptor beta	Homo sapiens	86-89
19713312-5	2009	Klotho(-/-) mice also showed intestinal Ca(2+) hyperabsorption, osteopenia, and renal precipitation of calcium-phosphate.	calcium phosphate	103-120	klotho	Mus musculus	0-6
19593649-13	2009	For ALP and OPN, gene expressions were activated earlier on hCaPs than untreated calcium phosphate (CaP) confirming the effect of the hybridization was substantial.	calcium phosphate	81-98	secreted phosphoprotein 1	Homo sapiens	12-15
19946326-1	2009	Fibroblast growth factor (FGF)-23 is a recently discovered regulator of calcium-phosphate metabolism.	calcium phosphate	72-89	fibroblast growth factor 23	Homo sapiens	0-33
19946326-5	2009	However, in cross-sectional studies increased FGF-23 levels in patients with CKD were found to be associated not only with therapy-resistant secondary hyperparathyroidism but were also independently related to myocardial hypertrophy and endothelial dysfunction after adjustment for traditional markers of calcium-phosphate metabolism.	calcium phosphate	305-322	fibroblast growth factor 23	Homo sapiens	46-52
19763629-12	2009	Increased bone turnover was coupled with an increased potential of calcium-phosphate precipitation, as shown by the increased Ca x P/fetuin-A.	calcium phosphate	67-84	alpha 2-HS glycoprotein	Homo sapiens	133-141
18985777-5	2009	Indices of osteogenic differentiation including the expression of osteopontin and alkaline phosphatase (ALP) were consistently higher in the nontreated and thin Ca-P-treated scaffolds when compared with thick Ca-P-treated scaffolds at 2 weeks.	calcium phosphate	161-165	alkaline phosphatase, placental	Homo sapiens	82-102
18985777-5	2009	Indices of osteogenic differentiation including the expression of osteopontin and alkaline phosphatase (ALP) were consistently higher in the nontreated and thin Ca-P-treated scaffolds when compared with thick Ca-P-treated scaffolds at 2 weeks.	calcium phosphate	161-165	alkaline phosphatase, placental	Homo sapiens	104-107
19822991-5	2009	These findings revealed that the osteoconductivity of calcium phosphate materials required the expression of BMPs as the prerequisite for Runx2 and Osterix expression.	calcium phosphate	54-71	RUNX family transcription factor 2	Rattus norvegicus	138-143
19375998-1	2009	Ascorbate-apatite and ascorbate-fibroblast growth factor-2 (FGF-2)-apatite composite layers were successfully formed on anodically oxidized Ti rods clinically used for external fixation by a one-step procedure at 25 degrees C, using a metastable supersaturated calcium phosphate solution supplemented with l-ascorbic acid phosphate magnesium salt n-hydrate (AsMg) and FGF-2.	calcium phosphate	261-278	fibroblast growth factor 2	Mus musculus	22-58
19822991-5	2009	These findings revealed that the osteoconductivity of calcium phosphate materials required the expression of BMPs as the prerequisite for Runx2 and Osterix expression.	calcium phosphate	54-71	Sp7 transcription factor	Rattus norvegicus	148-155
19107798-1	2009	AIMS: As a bioactive filler capable of remineralizing tooth structures, the main disadvantage of as-made amorphous calcium phosphate (am-ACP) are its large agglomerates.	calcium phosphate	115-132	CPAT1	Homo sapiens	137-140
19448536-4	2009	Noncollagenous matrix proteins produced in osteocytes, such as dentin matrix protein 1 (DMP1), have also been viewed as inert scaffolds for calcium-phosphate deposition.	calcium phosphate	140-157	dentin matrix acidic phosphoprotein 1	Homo sapiens	63-86
19448536-4	2009	Noncollagenous matrix proteins produced in osteocytes, such as dentin matrix protein 1 (DMP1), have also been viewed as inert scaffolds for calcium-phosphate deposition.	calcium phosphate	140-157	dentin matrix acidic phosphoprotein 1	Homo sapiens	88-92
19637574-4	2009	The recombinant pcDNA-CD5sp-VP2 plasmids were transfected into HEK293T cells mediated by calcium phosphate.	calcium phosphate	89-106	VP2	Canine parvovirus	28-31
19439823-10	2009	MCP-1 was also significantly expressed in beta-tricalcium phosphate (beta-TCP) and calcium phosphate cement samples (CPC) (p < 0.01).	calcium phosphate	50-67	C-C motif chemokine ligand 2	Homo sapiens	0-5
19185471-9	2009	This amorphous calcium phosphate acted as HAp precursor, skipping the induction period in SBF.	calcium phosphate	15-32	BAG cochaperone 1	Homo sapiens	42-45
19292864-3	2009	Small-angle X-ray scattering was used to confirm that a plasmin phosphopeptide of one of the identified proteins, osteopontin, formed a novel type of calcium phosphate nanocluster in which the radius of the amorphous calcium phosphate core was four times larger than is typical of casein nanoclusters.	calcium phosphate	150-167	plasminogen	Homo sapiens	56-63
19292864-3	2009	Small-angle X-ray scattering was used to confirm that a plasmin phosphopeptide of one of the identified proteins, osteopontin, formed a novel type of calcium phosphate nanocluster in which the radius of the amorphous calcium phosphate core was four times larger than is typical of casein nanoclusters.	calcium phosphate	150-167	secreted phosphoprotein 1	Homo sapiens	114-125
19292864-3	2009	Small-angle X-ray scattering was used to confirm that a plasmin phosphopeptide of one of the identified proteins, osteopontin, formed a novel type of calcium phosphate nanocluster in which the radius of the amorphous calcium phosphate core was four times larger than is typical of casein nanoclusters.	calcium phosphate	217-234	plasminogen	Homo sapiens	56-63
19292864-3	2009	Small-angle X-ray scattering was used to confirm that a plasmin phosphopeptide of one of the identified proteins, osteopontin, formed a novel type of calcium phosphate nanocluster in which the radius of the amorphous calcium phosphate core was four times larger than is typical of casein nanoclusters.	calcium phosphate	217-234	secreted phosphoprotein 1	Homo sapiens	114-125
19139991-0	2009	Osteoprotegerin (OPG) production by cells in the osteoblast lineage is regulated by pulsed electromagnetic fields in cultures grown on calcium phosphate substrates.	calcium phosphate	135-152	TNF receptor superfamily member 11b	Homo sapiens	0-15
19222044-1	2009	We report on the earliest stages of the formation of complexes of calcium phosphate in the presence of the serum protein alpha(2)-HS glycoprotein/fetuin-A termed calciprotein particles (CPPs).	calcium phosphate	66-83	alpha 2-HS glycoprotein	Homo sapiens	146-154
19139991-0	2009	Osteoprotegerin (OPG) production by cells in the osteoblast lineage is regulated by pulsed electromagnetic fields in cultures grown on calcium phosphate substrates.	calcium phosphate	135-152	TNF receptor superfamily member 11b	Homo sapiens	17-20
19139991-1	2009	Pulsed electromagnetic fields (PEMF) used clinically to stimulate bone formation enhance the osteogenic effects of BMP-2 on human mesenchymal stem cells (MSCs) if the MSCs are grown in osteogenic medium and are cultured on calcium phosphate (CaP) surfaces rather than tissue culture polystyrene plastic (TCPS).	calcium phosphate	223-240	bone morphogenetic protein 2	Homo sapiens	115-120
18286603-2	2009	The objective of this study was to investigate the influence of Na-HMP on several properties of calcium phosphate cements (CPCs).	calcium phosphate	96-113	inner membrane mitochondrial protein	Homo sapiens	67-70
19151743-7	2009	HEK 293T cells were transfected with plasmids encoding CXCR3 or its variants using calcium phosphate.	calcium phosphate	83-100	C-X-C motif chemokine receptor 3	Homo sapiens	55-60
18286623-7	2009	In m-SBF with and without albumin we found an amorphous layer of carbonated calcium phosphate with some calcium replaced by magnesium.	calcium phosphate	76-93	zinc finger protein 143	Homo sapiens	5-8
19012271-5	2009	FN adsorption kinetics and monolayer coverage was determined on SAMs with or without Ca-P coating.	calcium phosphate	85-89	fibronectin 1	Mus musculus	0-2
19262012-6	2009	Introduction of small interference RNA targeting p67(phox) or p22(phox) into RAW264.7 cells effectively down-regulated ROS generation and significantly suppressed the RANKL-stimulated differentiation, which was assessed by appearance of tartrate resistant acid phosphatase (TRAP)-positive, multinucleated cells having an ability to form resorption pits on calcium phosphate thin film-coated disks, and by expression of osteoclast marker genes (TRAP, cathepsin K, Atp6i, ClC-7, and NFATc1).	calcium phosphate	356-373	methionine aminopeptidase 2	Mus musculus	49-52
19262012-6	2009	Introduction of small interference RNA targeting p67(phox) or p22(phox) into RAW264.7 cells effectively down-regulated ROS generation and significantly suppressed the RANKL-stimulated differentiation, which was assessed by appearance of tartrate resistant acid phosphatase (TRAP)-positive, multinucleated cells having an ability to form resorption pits on calcium phosphate thin film-coated disks, and by expression of osteoclast marker genes (TRAP, cathepsin K, Atp6i, ClC-7, and NFATc1).	calcium phosphate	356-373	dynein cytoplasmic 1 heavy chain 1	Mus musculus	62-65
19262012-6	2009	Introduction of small interference RNA targeting p67(phox) or p22(phox) into RAW264.7 cells effectively down-regulated ROS generation and significantly suppressed the RANKL-stimulated differentiation, which was assessed by appearance of tartrate resistant acid phosphatase (TRAP)-positive, multinucleated cells having an ability to form resorption pits on calcium phosphate thin film-coated disks, and by expression of osteoclast marker genes (TRAP, cathepsin K, Atp6i, ClC-7, and NFATc1).	calcium phosphate	356-373	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	167-172
19188744-0	2009	Familial tumoral calcinosis caused by a novel FGF23 mutation: response to induction of tubular renal acidosis with acetazolamide and the non-calcium phosphate binder sevelamer.	calcium phosphate	141-158	fibroblast growth factor 23	Homo sapiens	46-51
18946870-3	2009	This work investigates the utility of PEGylated calcium phosphate nanoparticles as oral carriers for insulin.	calcium phosphate	48-65	insulin	Homo sapiens	101-108
18946870-11	2009	These results suggest PEGylated calcium phosphate nanoparticles as an excellent carrier system for insulin toward the development of an oral insulin delivery system.	calcium phosphate	32-49	insulin	Homo sapiens	99-106
19012271-9	2009	In addition, although the FN monolayer coverage is higher on Ca-P-coated --NH(2)-terminated SAMs and SiO(x) surfaces, higher levels of ALP activity and more cell growth are obtained on Ca-P-coated --OH- and --COOH-terminated SAMs.	calcium phosphate	61-65	fibronectin 1	Mus musculus	26-28
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	calcium phosphate	69-86	cyclin dependent kinase 1	Homo sapiens	18-22
19622896-1	2009	BACKGROUND: Fetuin-A is a major inhibitor of ectopic calcium phosphate precipitation and an acute phase reactant.	calcium phosphate	53-70	alpha 2-HS glycoprotein	Homo sapiens	12-20
19396320-3	2009	There are several well-known risk factors for DGF development, but the role of calcium phosphate-PTH homeostasis as a risk factor for early graft dysfunction is controversial.	calcium phosphate	79-96	parathyroid hormone	Homo sapiens	97-100
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	calcium phosphate	69-86	cyclin dependent kinase 1	Homo sapiens	43-47
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	calcium phosphate	69-86	cyclin dependent kinase 1	Homo sapiens	43-47
18266360-1	2008	Statherin is an active inhibitor of calcium phosphate precipitation in the oral cavity.	calcium phosphate	36-53	statherin	Homo sapiens	0-9
18041720-0	2008	Heparin modification of calcium phosphate bone cements for VEGF functionalization.	calcium phosphate	24-41	vascular endothelial growth factor A	Homo sapiens	59-63
18041720-2	2008	Recently, we reported on functionalization of Biocement D (BioD) and several modifications of this calcium phosphate bone cement with vascular endothelial growth factor (VEGF).	calcium phosphate	99-116	vascular endothelial growth factor A	Homo sapiens	134-168
18041720-2	2008	Recently, we reported on functionalization of Biocement D (BioD) and several modifications of this calcium phosphate bone cement with vascular endothelial growth factor (VEGF).	calcium phosphate	99-116	vascular endothelial growth factor A	Homo sapiens	170-174
18404656-10	2008	These results demonstrate that PEMF enhances osteogenic effects of BMP-2 on MSCs cultured on calcium phosphate substrates, suggesting that PEMF will improve MSC response to BMP-2 in vivo in a bone environment.	calcium phosphate	93-110	bone morphogenetic protein 2	Homo sapiens	67-72
18560273-2	2008	In performing cellular transfection using the calcium phosphate method, we noticed that the calcium phosphate precipitates (CPP) could induce LC3 punctation.	calcium phosphate	46-63	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	142-145
18560273-2	2008	In performing cellular transfection using the calcium phosphate method, we noticed that the calcium phosphate precipitates (CPP) could induce LC3 punctation.	calcium phosphate	92-109	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	142-145
18441302-5	2008	Electroporation and calcium phosphate-mediated procedures were used to deliver Trx1 and Trx2 expression constructs to RGCs in vivo and to cultured RGC-5 cells, respectively.	calcium phosphate	20-37	thioredoxin 1	Mus musculus	79-83
18441302-5	2008	Electroporation and calcium phosphate-mediated procedures were used to deliver Trx1 and Trx2 expression constructs to RGCs in vivo and to cultured RGC-5 cells, respectively.	calcium phosphate	20-37	thioredoxin 2	Mus musculus	88-92
18256019-3	2008	Osteopontin, as an inhibitor of crystal growth, potently influences the formation of calcium phosphate and calcium carbonate biominerals.	calcium phosphate	85-102	secreted phosphoprotein 1	Homo sapiens	0-11
18250169-0	2008	Mineralization of annexin-5-containing lipid-calcium-phosphate complexes: modulation by varying lipid composition and incubation with cartilage collagens.	calcium phosphate	45-62	annexin A5	Homo sapiens	18-27
19043984-6	2008	In patients treated with calcium phosphate adsorbed allergen there was a continous increase of catalase activity from beginning up to the end of observation.	calcium phosphate	25-42	catalase	Homo sapiens	95-103
18364352-0	2008	Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles.	calcium phosphate	94-111	alpha 2-HS glycoprotein	Homo sapiens	21-29
18724697-3	2008	pcDNA-GP5 was transfected into 293T by the calcium phosphate precipitation method.	calcium phosphate	43-60	glycoprotein V platelet	Homo sapiens	6-9
17597356-0	2008	Phase development and sintering behaviour of biphasic HA-TCP calcium phosphate materials prepared from hydroxyapatite and bioactive glass.	calcium phosphate	61-78	serine peptidase inhibitor Kazal type 1	Homo sapiens	57-60
17996293-1	2008	This study focused at the potential of transforming growth factor beta 1 (TGF-beta 1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites.	calcium phosphate	218-235	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	39-72
17996293-1	2008	This study focused at the potential of transforming growth factor beta 1 (TGF-beta 1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites.	calcium phosphate	218-235	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	74-84
18366455-6	2008	Indeed, cells on calcium phosphate without osteogenic differentiation additives developed to osteoblasts as shown by increased ALP activity and expression of osteogenic genes, which was not the case on tissue culture plastic.	calcium phosphate	17-34	alkaline phosphatase, placental	Homo sapiens	127-130
17497735-3	2008	Calcium phosphate ceramic is considered highly compatible to protein or peptide drugs, particularly insulin.	calcium phosphate	0-17	insulin	Homo sapiens	100-107
22460840-6	2008	Vitamin D, OPG/RANK/ RANK-L system, Matrix Gla-proteins (Mgp) and Fetuin-A/calcium phosphate mineral phase complex play an important role in the regulation of bone homeostasis and vascular calcifications.	calcium phosphate	75-92	alpha 2-HS glycoprotein	Homo sapiens	66-74
18791804-14	2008	CONCLUSION: Our findings indicate that the plasma FGF-23 level is associated with calcium-phosphate metabolism disorders, but not with aortic calcification, in both non-DM and DM patients on chronic HD.	calcium phosphate	82-99	fibroblast growth factor 23	Homo sapiens	50-56
19195551-5	2008	In the presence of calcium, however, t-SNARE vesicles interact with v-SNARE vesicles, allowing formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of coordinated water at the phosphate of the phospholipid head-groups, and due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion.	calcium phosphate	108-125	small NF90 (ILF3) associated RNA E	Homo sapiens	39-44
18753797-12	2008	CONCLUSIONS: The present observations disclose SGK1-sensitive glucocorticoid effects on calcium-phosphate metabolism and blood pressure.	calcium phosphate	88-105	serum/glucocorticoid regulated kinase 1	Mus musculus	47-51
19195551-5	2008	In the presence of calcium, however, t-SNARE vesicles interact with v-SNARE vesicles, allowing formation of calcium-phosphate bridges between the opposing bilayers, resulting in the expulsion of coordinated water at the phosphate of the phospholipid head-groups, and due to disruption of the water shell around the calcium ion, enabling lipid mixing and membrane fusion.	calcium phosphate	108-125	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	68-75
18458462-5	2007	The alkaline phosphatase (ALP) activity of SaOS-2 cells on a titanium plate coated with a calcium phosphate film was examined by conducting a culture test.	calcium phosphate	90-107	alkaline phosphatase, placental	Homo sapiens	4-24
17898038-3	2007	Here, we show that 10% of the mice lacking osteopontin (OPN) and 14.3% of the mice lacking Tamm-Horsfall protein (THP) spontaneously form interstitial deposits of calcium phosphate within the renal papillae, events never seen in wild-type mice.	calcium phosphate	163-180	secreted phosphoprotein 1	Mus musculus	43-54
17898038-3	2007	Here, we show that 10% of the mice lacking osteopontin (OPN) and 14.3% of the mice lacking Tamm-Horsfall protein (THP) spontaneously form interstitial deposits of calcium phosphate within the renal papillae, events never seen in wild-type mice.	calcium phosphate	163-180	secreted phosphoprotein 1	Mus musculus	56-59
17898038-3	2007	Here, we show that 10% of the mice lacking osteopontin (OPN) and 14.3% of the mice lacking Tamm-Horsfall protein (THP) spontaneously form interstitial deposits of calcium phosphate within the renal papillae, events never seen in wild-type mice.	calcium phosphate	163-180	uromodulin	Mus musculus	91-112
17898038-3	2007	Here, we show that 10% of the mice lacking osteopontin (OPN) and 14.3% of the mice lacking Tamm-Horsfall protein (THP) spontaneously form interstitial deposits of calcium phosphate within the renal papillae, events never seen in wild-type mice.	calcium phosphate	163-180	uromodulin	Mus musculus	114-117
17898038-5	2007	Urinalysis revealed elevated concentrations of urine phosphorus and brushite (calcium phosphate) supersaturation in THP-null and OPN/THP-double null mice, suggesting that impaired phosphorus handling may be linked to interstitial papillary calcinosis in THP- but not in OPN-null mice.	calcium phosphate	78-95	uromodulin	Mus musculus	116-119
17898038-5	2007	Urinalysis revealed elevated concentrations of urine phosphorus and brushite (calcium phosphate) supersaturation in THP-null and OPN/THP-double null mice, suggesting that impaired phosphorus handling may be linked to interstitial papillary calcinosis in THP- but not in OPN-null mice.	calcium phosphate	78-95	secreted phosphoprotein 1	Mus musculus	129-132
17898038-8	2007	These data establish OPN and THP as powerful and functionally synergistic inhibitors of calcium phosphate and calcium oxalate crystallization in vivo and suggest that defects in either molecule may contribute to renal calcinosis and stone formation, an exceedingly common condition that afflicts up to 12% males and 5% females.	calcium phosphate	88-105	secreted phosphoprotein 1	Mus musculus	21-24
17898038-8	2007	These data establish OPN and THP as powerful and functionally synergistic inhibitors of calcium phosphate and calcium oxalate crystallization in vivo and suggest that defects in either molecule may contribute to renal calcinosis and stone formation, an exceedingly common condition that afflicts up to 12% males and 5% females.	calcium phosphate	88-105	uromodulin	Mus musculus	29-32
17700718-4	2007	EXPERIMENTAL APPROACH: Ca((V))1.2 channels were transfected into HEK 293 cells, using the calcium phosphate precipitation method, and currents were measured using the whole-cell patch clamp technique.	calcium phosphate	90-107	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	23-33
18333806-0	2008	Non-viral bone morphogenetic protein 2 transfection of rat dental pulp stem cells using calcium phosphate nanoparticles as carriers.	calcium phosphate	88-105	bone morphogenetic protein 2	Rattus norvegicus	10-38
18333806-2	2008	The aim of this study was to induce bone morphogenetic protein (Bmp)2 transfection in rat dental pulp stem cells using calcium phosphate nanoparticles as a gene vector and then to evaluate the efficiency and bioactivity of the transfection.	calcium phosphate	119-136	bone morphogenetic protein 2	Rattus norvegicus	64-69
18333806-4	2008	Nanoparticles of calcium phosphate encapsulating plasmid deoxyribonucleic acid (DNA) (plasmid enhanced green fluorescent protein-BMP2) were prepared.	calcium phosphate	17-34	bone morphogenetic protein 2	Rattus norvegicus	129-133
18333806-13	2008	Based on our results, plasmid DNA-loaded calcium phosphate nanoparticles appear to be an effective non-viral vector for gene delivery and functioned well for odontogenic differentiation through Bmp2 transfection.	calcium phosphate	41-58	bone morphogenetic protein 2	Rattus norvegicus	194-198
17613532-2	2007	Anx-A5 significantly activated the induction and propagation of mineral formation when incorporated into synthetic nucleation complexes made of amorphous calcium phosphate (ACP) and Anx-A5 or of phosphatidylserine (PS) plus ACP (PS-CPLX) and Anx-A5.	calcium phosphate	154-171	annexin A5	Homo sapiens	0-6
18458462-5	2007	The alkaline phosphatase (ALP) activity of SaOS-2 cells on a titanium plate coated with a calcium phosphate film was examined by conducting a culture test.	calcium phosphate	90-107	alkaline phosphatase, placental	Homo sapiens	26-29
18458462-6	2007	Calcium phosphate coating increased the ALP activity of SaOS-2 cells cultured for 3 and 7 days.	calcium phosphate	0-17	alkaline phosphatase, placental	Homo sapiens	40-43
17389622-8	2007	Fetuin-A-deficient mice with CKD and high phosphate diet had only a moderately elevated serum calcium phosphate product (6.9 +/- 1.4 mmol(2)/l(2)), but suffered severe calcification of kidney, heart and lung.	calcium phosphate	94-111	alpha-2-HS-glycoprotein	Mus musculus	0-8
18458444-0	2007	Fibronectin-calcium phosphate composite layer on hydroxyapatite to enhance adhesion, cell spread and osteogenic differentiation of human mesenchymal stem cells in vitro.	calcium phosphate	12-29	fibronectin 1	Homo sapiens	0-11
18458444-1	2007	Fibronectin (Fn) and type I collagen (Col) were immobilized on a surface of a hydroxyapatite (HAP) ceramic by coprecipitation with calcium phosphate in a supersaturated calcium phosphate solution prepared by mixing clinically approved infusion fluids.	calcium phosphate	131-148	fibronectin 1	Homo sapiens	0-11
18458444-4	2007	When human mesenchymal stem cells (hMSCs) were cultured on a HAP ceramic in a differentiation medium supplemented with dexamethasone, beta-glycerophosphate and ascorbic acid, hMSCs spread well within 1 h. The alkaline phosphatase (ALP) activity of hMSCs cultured on the Fn-calcium phosphate composite layer significantly increased compared with that of hMSCs cultured on the untreated HAP ceramic.	calcium phosphate	273-290	alkaline phosphatase, placental	Homo sapiens	209-229
17854564-2	2007	METHODS: In this study, we used ERalpha or ERbeta over-expressing Hela cells to observe the transcriptional regulation of genistein and daidzein on ERE reporter gene with calcium-phosphate method, and furthermore observing the effects of phytoestrogen antagonist ICI 182780 on their activation.	calcium phosphate	171-188	estrogen receptor 1	Homo sapiens	32-39
17189469-7	2007	When BMP-2 was incorporated into calcium-phosphate coatings, it was a potent bone-inducer, whose efficacy was compromised, not potentiated, by the additional deposition of an adsorbed pool.	calcium phosphate	33-50	bone morphogenetic protein 2	Homo sapiens	5-10
17368425-4	2007	FRP-1-mediated osteoclasts formed larger pits on mineralized calcium phosphate plates than RANKL+M-CSF-mediated osteoclasts did.	calcium phosphate	61-78	secreted frizzled related protein 1	Homo sapiens	0-5
17133509-0	2007	Calcium phosphate bone cements, functionalized with VEGF: release kinetics and biological activity.	calcium phosphate	0-17	vascular endothelial growth factor A	Homo sapiens	52-56
20408632-2	2007	The plasma protein fetuin-A inhibits calcium phosphate deposition by forming colloidal calciprotein particles (CPPs).	calcium phosphate	37-54	alpha 2-HS glycoprotein	Homo sapiens	19-27
17052245-0	2007	Optimization of transfection mediated by calcium phosphate for plasmid rAAV-LacZ (recombinant adeno-associated virus-beta-galactosidase reporter gene) production in suspension-cultured HEK-293 (human embryonic kidney 293) cells.	calcium phosphate	41-58	galactosidase beta 1	Homo sapiens	117-135
17851170-4	2007	This investigation assessed the elution characteristics of BMP-7 (OP-1) from hollow calcium phosphate spheres of varying chemical composition (HA/beta-TCP) and porosity (dense/porous).	calcium phosphate	84-101	bone morphogenetic protein 7	Homo sapiens	59-64
17851170-4	2007	This investigation assessed the elution characteristics of BMP-7 (OP-1) from hollow calcium phosphate spheres of varying chemical composition (HA/beta-TCP) and porosity (dense/porous).	calcium phosphate	84-101	bone morphogenetic protein 7	Homo sapiens	66-70
17851170-11	2007	These preliminary in vitro and ex vivo results indicate the clinical potential of the hollow calcium phosphate carriers as successful load-bearing delivery vehicles for OP-1.	calcium phosphate	93-110	bone morphogenetic protein 7	Homo sapiens	169-173
17305007-9	2007	in the aspect of quantity and quality of bone formation, histology showed that PRP/MSCs/beta-TCP and auto-radius were better than MSCs/beta-TCP (P < 0.05), and there was no significant difference between PRP/MSCs/beta-TCP and auto-radius (P>0.05).	calcium phosphate	88-96	major prion protein	Oryctolagus cuniculus	79-82
17915689-3	2007	Batch and fixed-bed column experiments of seeded crystallization of calcium phosphate were undertaken by using synthetic wastewater with 10 mgP/L.	calcium phosphate	68-85	matrix Gla protein	Homo sapiens	140-143
17305007-12	2007	In the aspect of intensity of bone formation, at 6 and 12 weeks, PRP/MSCs/beta-TCP and auto-radius were better than MSCs/beta-TCP (P<0.05).	calcium phosphate	74-82	major prion protein	Oryctolagus cuniculus	65-68
16848930-0	2006	Inhibitory activity of bovine milk osteopontin and its fragments on the formation of calcium phosphate precipitates.	calcium phosphate	85-102	secreted phosphoprotein 1	Bos taurus	35-46
17036981-1	2006	OBJECTIVE: To study in vitro sustained release behaviour of the recombinant human bone morphogenetic protein 2 (rhBMP-2) from the sample which porous calcium phosphate cement (PCPC) was combined with rhBMP-2, and to evaluate the effect of PCPC/rhBMP-2 composite on repairing bone defect in the animal study.	calcium phosphate	150-167	bone morphogenetic protein 2	Homo sapiens	82-110
16995778-0	2006	Transforming growth factor-beta1 release from a porous electrostatic spray deposition-derived calcium phosphate coating.	calcium phosphate	94-111	transforming growth factor beta 1	Homo sapiens	0-32
16995778-8	2006	In conclusion, a porous ESD-derived calcium phosphate coating can be used as a carrier material for TGF-beta1, when a burst release is desired.	calcium phosphate	36-53	transforming growth factor beta 1	Homo sapiens	100-109
16969594-2	2006	In vitro studies suggest that BSP may play important roles in the initiation and/or growth of calcium-phosphate crystals.	calcium phosphate	94-111	integrin-binding sialoprotein	Rattus norvegicus	30-33
16906034-11	2006	Efforts to improve calcium-phosphate-PTH homeostasis in patients on the waiting list for renal transplantation should be encouraged also to improve graft survival.	calcium phosphate	19-36	parathyroid hormone	Homo sapiens	37-40
16569393-2	2006	Thus, the aim of this investigation was to evaluate the effects of adding various concentrations of calcium phosphate to self-made mucin-containing solutions on demineralised bovine enamel in vitro.	calcium phosphate	100-117	mucin 1, cell surface associated	Bos taurus	131-136
16818982-2	2006	This study was performed to evaluate the efficacy of the use of recombinant bone morphogenetic protein-2 (rhBMP-2) delivered in an injectable calcium phosphate cement (alpha bone substitute material [alpha-BSM]) to bridge critical-sized defects in the rabbit radius.	calcium phosphate	142-159	bone morphogenetic protein 2	Oryctolagus cuniculus	76-104
16557100-16	2006	Serum calcium and treatment with calcitriol emerged as predictive variables of coronary score.Fetuin-A could be involved in the process of calcification both in the case of markedly low serum levels, due to decreased prevention of calcium phosphate precipitation, and also as a marker of inflammation, a well-known risk factor of atherogenesis.	calcium phosphate	231-248	alpha 2-HS glycoprotein	Homo sapiens	94-102
16436294-0	2006	The modulation of gene expression in osteoblasts by thrombin coated on biphasic calcium phosphate ceramic.	calcium phosphate	80-97	coagulation factor II	Mus musculus	52-60