PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32082103-0	2019	Corrigendum: 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis.	2-pyrrolidone	13-28	4-aminobutyrate aminotransferase	Homo sapiens	82-99
3871791-3	1985	The low production of IL-1 in vitro correlated with patients" symptoms and therapy with 1-acetamide,2-pyrrolidone (1a,2p).	2-pyrrolidone	100-113	interleukin 1 alpha	Homo sapiens	22-26
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	2-pyrrolidone	38-51	interleukin 1 alpha	Homo sapiens	93-106
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	2-pyrrolidone	38-51	interleukin 1 alpha	Homo sapiens	108-112
33924091-0	2021	Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase.	2-pyrrolidone	57-73	monoglyceride lipase	Homo sapiens	97-120
33924091-1	2021	Ten benzoxazole clubbed 2-pyrrolidinones (11-20) as human monoacylglycerol lipase inhibitors were designed on the criteria fulfilling the structural requirements and on the basis of previously reported inhibitors.	2-pyrrolidone	24-40	monoglyceride lipase	Homo sapiens	58-81
32575154-0	2020	Pyrrolidin-2-one Linked Benzofused Heterocycles as Novel Small Molecule Monoacylglycerol Lipase Inhibitors and Antinociceptive Agents.	2-pyrrolidone	0-16	monoglyceride lipase	Homo sapiens	72-95
31980341-0	2020	Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.	2-pyrrolidone	111-126	tyrosine kinase 2	Homo sapiens	164-168
32480172-2	2020	We introduced 2-pyrrolidinone to form the 5-atoms linker for c-Met inhibitor and hydroxamic acid as a zinc binding motif for HDAC inhibitor.	2-pyrrolidone	14-29	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	61-66
31133775-10	2019	In the analysis of clinical EDTA plasma samples, the levels of succinimide and 2-pyrrolidinone showed a high level of correlation (R = 0.73), indicating impairment in GABA metabolism and further supporting the association with GABA-transaminase deficiency and the pathogenicity of the ABAT variants.	2-pyrrolidone	79-94	4-aminobutyrate aminotransferase	Homo sapiens	227-244
31864778-0	2020	Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.	2-pyrrolidone	19-34	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	110-119
31864778-4	2020	In the present work a novel class of ATX inhibitors, optically active derivatives of 2-pyrrolidinone and pyrrolidine heterocycles were synthesized.	2-pyrrolidone	85-100	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	37-40
31133775-10	2019	In the analysis of clinical EDTA plasma samples, the levels of succinimide and 2-pyrrolidinone showed a high level of correlation (R = 0.73), indicating impairment in GABA metabolism and further supporting the association with GABA-transaminase deficiency and the pathogenicity of the ABAT variants.	2-pyrrolidone	79-94	4-aminobutyrate aminotransferase	Homo sapiens	285-289
31133775-11	2019	Further analysis of metabolomic data across our patient population revealed the association of elevated levels of 2-pyrrolidinone with administration of vigabatrin, a commonly used anti-seizure medication and a known inhibitor of GABA-transaminase.	2-pyrrolidone	114-129	4-aminobutyrate aminotransferase	Homo sapiens	230-247
16982190-0	2006	Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.	2-pyrrolidone	62-79	coagulation factor X	Homo sapiens	40-49
30003787-2	2018	This highly efficient and enantioselective approach allows the rapid installation of the four contiguous chiral centers (C16, C15, C20, and C19) by way of a dual Ir/amine catalytic allylation of 2-indolyl vinyl carbinol 6 and an aldol reaction of resultant chiral aldehyde 4a with 2-pyrrolidinone 5.	2-pyrrolidone	281-296	placenta associated 8	Homo sapiens	126-129
29623974-5	2018	Subsequently, for the Pd(0)-catalyzed intermolecular hydroamination of 1,1-diphenyl MCP with 2-pyrrolidone, it is more favorable for the C1 of the metallacyclobutane intermediate to undergo protonation to yield a pi-allylpalladium intermediate, from which the final allylamine product is afforded via reductive elimination.	2-pyrrolidone	93-106	capping actin protein, gelsolin like	Homo sapiens	84-87
29468109-4	2016	Recombinant Escherichia coli was metabolically engineered for the production of 2-pyrrolidone from glutamate by expressing both the genes encoding GadB, a glutamate decarboxylase, and ORF27.	2-pyrrolidone	80-93	hypothetical protein	Escherichia coli	184-189
26140617-0	2015	A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.	2-pyrrolidone	40-54	beta-secretase 1	Homo sapiens	145-150
23582449-3	2013	Experiments with electrically stimulated rat vas deference contractions induced by the PRE-084, an agonist of sigma-1 receptor, showed that (4R,5S)- and (4R,5R)-2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamides with an R-configuration at the C-4 chiral centre in the 2-pyrrolidone ring were more effective positive allosteric modulators of sigma-1 receptor than were their optical antipodes.	2-pyrrolidone	271-284	sigma non-opioid intracellular receptor 1	Rattus norvegicus	110-126
21349710-0	2011	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.	2-pyrrolidone	61-78	coagulation factor X	Homo sapiens	39-48
29086859-0	2017	Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRbeta inhibitors.	2-pyrrolidone	48-61	kinase insert domain receptor	Homo sapiens	131-138
29086859-0	2017	Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRbeta inhibitors.	2-pyrrolidone	48-61	platelet derived growth factor receptor beta	Homo sapiens	139-148
29086859-2	2017	Compared to sunitinib, the C(5)-Br derivative of 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole has significantly greater in vitro activities against VEGFR-2, PDGFRbeta, and tube formation.	2-pyrrolidone	49-62	kinase insert domain receptor	Homo sapiens	161-168
29086859-2	2017	Compared to sunitinib, the C(5)-Br derivative of 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole has significantly greater in vitro activities against VEGFR-2, PDGFRbeta, and tube formation.	2-pyrrolidone	49-62	platelet derived growth factor receptor beta	Homo sapiens	170-179
20006499-0	2010	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.	2-pyrrolidone	61-78	coagulation factor X	Homo sapiens	39-48
18378220-1	2008	We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside.	2-pyrrolidone	82-101	GABA type A receptor-associated protein	Homo sapiens	165-178
18054228-0	2008	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.	2-pyrrolidone	61-78	coagulation factor X	Homo sapiens	39-48
16931002-0	2006	Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.	2-pyrrolidone	27-39	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	40-51
16931002-1	2006	A series of metabolically stable butyrolactam 11beta-HSD1 inhibitors have been synthesized and biologically evaluated.	2-pyrrolidone	33-45	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	46-57
15530117-1	2004	Pyrrolidin-2-one (gamma-lactam) derivatives have shown a wide range of activities as ligands to diverse receptors, e.g., integrin, CCR5, and CCK.	2-pyrrolidone	0-16	C-C motif chemokine receptor 5	Homo sapiens	131-135
16909866-5	2006	A PCR analysis of the minimal promoter region of the tumor suppressor PTEN in the presence of 2-pyrrolidone in 101 patients from Moscow clinics revealed changes in it in patients with endometrial (56%) or ovarian (29%) cancer, as well as in patients with endometrial hyperplasia and benign ovarian tumors (34.6 and 29%, respectively).	2-pyrrolidone	94-107	phosphatase and tensin homolog	Homo sapiens	70-74
16928049-1	2006	A convergent synthesis of structurally novel butyrolactam 11beta-HSD1 inhibitors is described.	2-pyrrolidone	45-57	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	58-69
16078837-5	2005	The cyclopentanone and 2-pyrrolidinone analogues 45 and 57 showed low nM BACE inhibition.	2-pyrrolidone	23-38	beta-secretase 1	Homo sapiens	73-77
15530117-1	2004	Pyrrolidin-2-one (gamma-lactam) derivatives have shown a wide range of activities as ligands to diverse receptors, e.g., integrin, CCR5, and CCK.	2-pyrrolidone	0-16	cholecystokinin	Homo sapiens	141-144
15340208-2	2004	The reaction probably involves oxidative Grob fragmentation yielding imino aldehyde, which upon hydrolysis produces 2-pyrrolidinone via a cyclization-oxidation sequence.	2-pyrrolidone	116-131	C-X-C motif chemokine ligand 2	Homo sapiens	41-45
11834304-7	2002	Potentiation of GluR1,2,3 channel currents obtained with 2-pyrrolidinone was inhibited by KN-93, a selective inhibitor of calcium/calmodulin-dependent protein kinase (CaMKII), while it was not affected by GF109203X, a selective inhibitor of protein kinase C or H-89, a selective inhibitor of cAMP-dependent protein kinase.	2-pyrrolidone	57-72	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	16-25
14583340-7	2003	2-Pyrrolidone levels in the lung hydrolysates from ec-sod null mice were increased at both 7 and 14 d post-bleomycin treatment as compared to wild-type mice, indicating EC-SOD can inhibit oxidative fragmentation of proteins in this specific model of oxidative stress.	2-pyrrolidone	0-13	superoxide dismutase 3, extracellular	Mus musculus	51-57
14583340-7	2003	2-Pyrrolidone levels in the lung hydrolysates from ec-sod null mice were increased at both 7 and 14 d post-bleomycin treatment as compared to wild-type mice, indicating EC-SOD can inhibit oxidative fragmentation of proteins in this specific model of oxidative stress.	2-pyrrolidone	0-13	superoxide dismutase 3, extracellular	Mus musculus	169-175
14499485-4	2003	In the Western immunoblot analysis, rat hippocampal slices treated with 2-pyrrolidinone (100 nM) was more reactive to an antibody against phosphorylated myristoylated alanine-rich C kinase substrate (MARCKS) than untreated slices.	2-pyrrolidone	72-87	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	153-198
14499485-4	2003	In the Western immunoblot analysis, rat hippocampal slices treated with 2-pyrrolidinone (100 nM) was more reactive to an antibody against phosphorylated myristoylated alanine-rich C kinase substrate (MARCKS) than untreated slices.	2-pyrrolidone	72-87	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	200-206
14499485-5	2003	2-Pyrrolidinone (100 nM) induced a long-lasting facilitation of hippocampal synaptic transmission in the CA1 region of rat hippocampal slices, and the facilitation was inhibited by GF109203X or alpha-bungarotoxin, an inhibitor of alpha7 receptors.	2-pyrrolidone	0-15	carbonic anhydrase 1	Rattus norvegicus	105-108
11834304-8	2002	The results of the present study suggest that 2-pyrrolidinone persistently enhances activity of the Ca2+-permeable AMPA receptors, GluR1,3 and GluR1,2,3, by interacting with CaMKII.	2-pyrrolidone	46-61	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	131-136
11834304-8	2002	The results of the present study suggest that 2-pyrrolidinone persistently enhances activity of the Ca2+-permeable AMPA receptors, GluR1,3 and GluR1,2,3, by interacting with CaMKII.	2-pyrrolidone	46-61	glutamate receptor, ionotropic, AMPA 1 L homeolog	Xenopus laevis	143-152
10888564-6	2000	The samples containing MSG also produced 2-pyrrolidone, and the samples containing sugar also produced furfural and 5-hydroxy methyl furfural.	2-pyrrolidone	41-54	MLP-like protein 28-like	Glycine max	23-26
9621412-0	1998	2-Oxopyrrolidines and 6-oxoperhydropyrrolo[1,2-a]pyrazines as templates in the search for nonpeptide cholecystokinin ligands.	2-pyrrolidone	0-17	cholecystokinin	Homo sapiens	101-116
10450950-1	1999	A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase.	2-pyrrolidone	2-17	neuraminidase 1	Homo sapiens	199-212
9621412-2	1998	This tactic yielded a series of monocyclic 2-oxopyrrolidine derivatives 4 with selectivity for CCK-A or CCK-B receptors and with slightly improved binding affinity at the CCK-A receptor subtype with respect to the model 3-oxoindolizidines.	2-pyrrolidone	43-59	cholecystokinin A receptor	Homo sapiens	95-100
9621412-2	1998	This tactic yielded a series of monocyclic 2-oxopyrrolidine derivatives 4 with selectivity for CCK-A or CCK-B receptors and with slightly improved binding affinity at the CCK-A receptor subtype with respect to the model 3-oxoindolizidines.	2-pyrrolidone	43-59	cholecystokinin B receptor	Homo sapiens	104-109
9621412-2	1998	This tactic yielded a series of monocyclic 2-oxopyrrolidine derivatives 4 with selectivity for CCK-A or CCK-B receptors and with slightly improved binding affinity at the CCK-A receptor subtype with respect to the model 3-oxoindolizidines.	2-pyrrolidone	43-59	cholecystokinin A receptor	Homo sapiens	171-185
8811836-4	1996	The expression of PAP activity displayed an absolute requirement for the presence of a disulphide bond-reducing agent such as DTT, whilst optimum activity was observed at pH 8.5. strong inhibition of PAP activity was observed with a number of different agents, including transition metal ions, sulphydryl-blocking agents and 2-pyrrolidone (a pGlu analog).	2-pyrrolidone	325-338	PDGFA associated protein 1	Homo sapiens	18-21
8811836-4	1996	The expression of PAP activity displayed an absolute requirement for the presence of a disulphide bond-reducing agent such as DTT, whilst optimum activity was observed at pH 8.5. strong inhibition of PAP activity was observed with a number of different agents, including transition metal ions, sulphydryl-blocking agents and 2-pyrrolidone (a pGlu analog).	2-pyrrolidone	325-338	PDGFA associated protein 1	Homo sapiens	200-203