PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8172095-0	1994	Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus.	Vitamin D	11-20	insulin	Homo sapiens	24-31
8033198-1	1994	Calbindin-D28k (CaBP), previously localized in some of the cell bodies of ganglia of the avian intestinal (Remark"s) nerve, was shown to be vitamin D-dependent.	Vitamin D	140-149	S100 calcium binding protein G	Homo sapiens	16-20
8033198-7	1994	Activation time after vitamin D-repletion was correlated with an increase in CaBP and plasma Ca2+ levels.	Vitamin D	22-31	S100 calcium binding protein G	Homo sapiens	77-81
7926631-0	1994	The relation of the dual thyroxine/vitamin D-binding protein (TBP/DBP) of emydid turtles to vitamin D-binding proteins of other vertebrates.	Vitamin D	35-44	TATA-box binding protein	Gallus gallus	62-65
8092975-2	1994	Tissue resistance to vitamin D, or vitamin D-dependent rickets (VDDR), can be classified as two separate conditions--VDDR type I and VDDR type II--both of which present with the classical clinical, radiological and biochemical features of rickets despite adequate vitamin D intake.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-68
8092975-2	1994	Tissue resistance to vitamin D, or vitamin D-dependent rickets (VDDR), can be classified as two separate conditions--VDDR type I and VDDR type II--both of which present with the classical clinical, radiological and biochemical features of rickets despite adequate vitamin D intake.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	117-121
8092975-2	1994	Tissue resistance to vitamin D, or vitamin D-dependent rickets (VDDR), can be classified as two separate conditions--VDDR type I and VDDR type II--both of which present with the classical clinical, radiological and biochemical features of rickets despite adequate vitamin D intake.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	117-121
8092975-2	1994	Tissue resistance to vitamin D, or vitamin D-dependent rickets (VDDR), can be classified as two separate conditions--VDDR type I and VDDR type II--both of which present with the classical clinical, radiological and biochemical features of rickets despite adequate vitamin D intake.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-68
8092975-2	1994	Tissue resistance to vitamin D, or vitamin D-dependent rickets (VDDR), can be classified as two separate conditions--VDDR type I and VDDR type II--both of which present with the classical clinical, radiological and biochemical features of rickets despite adequate vitamin D intake.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	117-121
8092975-2	1994	Tissue resistance to vitamin D, or vitamin D-dependent rickets (VDDR), can be classified as two separate conditions--VDDR type I and VDDR type II--both of which present with the classical clinical, radiological and biochemical features of rickets despite adequate vitamin D intake.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	117-121
8092975-6	1994	VDDR I is caused by decreased production of the active form of vitamin D, 1,25-dihydroxycholecalciferol, with the proposed defect being in the gene encoding the enzyme 1 alpha-hydroxylase.	Vitamin D	63-72	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-6
8014199-6	1994	NMP-2 exhibits recognition for a promoter domain contiguous to the vitamin D-responsive element of the osteocalcin gene, although the vitamin D receptor does not appear to be a component of the nuclear matrix proteins.	Vitamin D	67-76	bone gamma-carboxyglutamate protein	Rattus norvegicus	103-114
8147918-5	1994	Using a vitamin D-inducible growth hormone gene reporter system we were able to demonstrate that MC 1288 induces human growth hormone (hGH) activity 30-fold more efficiently than 1,25-(OH)2D3 in the presence of fetal calf serum (FCS), while the analog is only 10 times more efficient than 1,25-(OH)2D3 in the absence of FCS.	Vitamin D	8-17	growth hormone 1	Homo sapiens	28-42
8147918-5	1994	Using a vitamin D-inducible growth hormone gene reporter system we were able to demonstrate that MC 1288 induces human growth hormone (hGH) activity 30-fold more efficiently than 1,25-(OH)2D3 in the presence of fetal calf serum (FCS), while the analog is only 10 times more efficient than 1,25-(OH)2D3 in the absence of FCS.	Vitamin D	8-17	growth hormone 1	Homo sapiens	119-133
8172095-1	1994	Vitamin D has been shown to increase insulin release from pancreatic islet cells in vitro, and to improve insulin secretion in vitamin D-deficient animals.	Vitamin D	0-9	insulin	Homo sapiens	37-44
8081065-4	1994	Vitamin D insufficiency and a deficit in calcium intake are very common in the elderly living either in institutions or at home and the cumulative response to these deficits is a negative calcium balance which stimulates parathyroid hormone secretion.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	221-240
8140927-8	1994	However, sequences between -678 and -476 bp, which also includes the vitamin D response element (VDRE), were able to confer bFGF inducibility on both a minimal osteocalcin and a heterologous promoter.	Vitamin D	69-78	fibroblast growth factor 2	Homo sapiens	124-128
8140927-8	1994	However, sequences between -678 and -476 bp, which also includes the vitamin D response element (VDRE), were able to confer bFGF inducibility on both a minimal osteocalcin and a heterologous promoter.	Vitamin D	69-78	bone gamma-carboxyglutamate protein	Homo sapiens	160-171
8286356-0	1994	DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene.	Vitamin D	76-85	bone gamma-carboxyglutamate protein	Rattus norvegicus	131-142
8286356-4	1994	Together, these elements regulate basal and vitamin D enhanced osteocalcin gene transcription.	Vitamin D	44-53	bone gamma-carboxyglutamate protein	Rattus norvegicus	63-74
8286356-6	1994	Both in confluent cultures and in response to vitamin D, when osteocalcin transcription was upregulated, the hypersensitive bands were significantly intensified.	Vitamin D	46-55	bone gamma-carboxyglutamate protein	Rattus norvegicus	62-73
7857076-6	1994	Main factors which regulate PTH synthesis are the level of extra-cellular calcium, vitamin D, and to a lesser extent steroid hormones.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	28-31
8344702-0	1993	Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937.	Vitamin D	28-37	interleukin 1 beta	Homo sapiens	59-77
8243336-1	1993	The osteocalcin (OC) gene was initially described as a single copy gene encoding the bone specific vitamin K dependent and vitamin D regulated protein.	Vitamin D	123-132	bone gamma-carboxyglutamate protein	Rattus norvegicus	4-15
8243336-1	1993	The osteocalcin (OC) gene was initially described as a single copy gene encoding the bone specific vitamin K dependent and vitamin D regulated protein.	Vitamin D	123-132	bone gamma-carboxyglutamate protein	Rattus norvegicus	17-19
8257667-1	1993	The compartmental organization of visual cortical neurons was examined across species of primates by directly comparing the pattern of immunoreactivity for the 28-kD vitamin D-dependent calcium-binding protein (calbindin) in area 17 of squirrel monkeys, macaques, and neurologically normal adult humans.	Vitamin D	166-175	centrin 1	Homo sapiens	186-209
8257667-1	1993	The compartmental organization of visual cortical neurons was examined across species of primates by directly comparing the pattern of immunoreactivity for the 28-kD vitamin D-dependent calcium-binding protein (calbindin) in area 17 of squirrel monkeys, macaques, and neurologically normal adult humans.	Vitamin D	166-175	centrin 1	Homo sapiens	211-220
8218210-3	1993	In this study, we established that the -1097 to +23 promoter (pOCZCat) of the rat OC gene confers glucocorticoid responsiveness to both basal and vitamin D-induced OC expression.	Vitamin D	146-155	bone gamma-carboxyglutamate protein	Rattus norvegicus	63-65
8218210-3	1993	In this study, we established that the -1097 to +23 promoter (pOCZCat) of the rat OC gene confers glucocorticoid responsiveness to both basal and vitamin D-induced OC expression.	Vitamin D	146-155	bone gamma-carboxyglutamate protein	Rattus norvegicus	82-84
8218210-10	1993	The presence of multiple GR binding sites in the rat OC gene proximal promoter indicates that regulation of basal and vitamin D-enhanced transcription by glucocorticoids may involve the integrated activities of multiple, independent GREs.	Vitamin D	118-127	bone gamma-carboxyglutamate protein	Rattus norvegicus	53-55
8212205-5	1993	Aggressive oral calcium and vitamin D supplementation in certain normocalcemic renal transplant patients may decrease endogenous PTH levels, improve hypophosphatemia, and provide a physiologic increase in levels of 1-25(OH)2D3.	Vitamin D	28-37	parathyroid hormone	Homo sapiens	129-132
8396012-13	1993	Furthermore, comparison of the transient elevation of calcium absorption by OCT with its more prolonged effects on PTH and calbindin D9k indicates that each action of vitamin D compounds has a distinct biological half-life.	Vitamin D	167-176	parathyroid hormone	Rattus norvegicus	115-118
8370586-0	1993	Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP).	Vitamin D	25-34	D-box binding PAR bZIP transcription factor	Homo sapiens	120-123
8370586-6	1993	Those of the DBP genetic forms to the vitamin D derivatives 25-OH-D3 and 1,25-(OH)2-D3 seem to be related to the isoelectric point of the proteins: a high affinity corresponding to a low isoelectric point.	Vitamin D	38-47	D-box binding PAR bZIP transcription factor	Homo sapiens	13-16
8394351-4	1993	In several steps we converted the retinoid specific response element of the human retinoic acid receptor beta promoter into the vitamin D/retinoic acid response element of the human osteocalcin promoter.	Vitamin D	128-137	bone gamma-carboxyglutamate protein	Homo sapiens	182-193
8390690-0	1993	Transport of phosphate by plasma membranes of the jejunum and kidney of the mouse model of hypophosphatemic vitamin D-resistant rickets.	Vitamin D	108-117	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	91-107
8390690-1	1993	The hypophosphatemic mouse is a useful model for the study of hypophosphatemic vitamin D-resistant rickets in humans.	Vitamin D	79-88	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	4-20
8390690-1	1993	The hypophosphatemic mouse is a useful model for the study of hypophosphatemic vitamin D-resistant rickets in humans.	Vitamin D	79-88	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	62-78
7689318-2	1993	AFP, whose precise function is unknown, has been classified as belonging to a protein superfamily together with albumin and vitamin D-binding (Gc) protein.	Vitamin D	124-133	alpha fetoprotein	Homo sapiens	0-3
8179318-2	1994	The purified receptor is homogeneous, and is bound by 1,25-dihydroxyvitamin D3 with a Kd of 5 x 10(-10) M. The isolated receptor binds to the osteocalcin vitamin D response element in the presence of porcine intestinal nuclear extract stripped of endogenous vitamin D receptor as well.	Vitamin D	68-77	bone gamma-carboxyglutamate protein	Rattus norvegicus	142-153
8238086-5	1993	The administration of vitamin D 200,000 U/month or calcitriol 0.5 microgram daily and 1 g of Ca supplementation daily, resulted in the normalization of PTH during 81 months of follow-up.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	152-155
8238086-8	1993	This observation suggests that serum PTH could be an early marker for the detection of recurrence in parathyroid cancer with normal serum Ca, and that suppression of PTH secretion by vitamin D or calcitriol could avert or delay the progression of recurrence.	Vitamin D	183-192	parathyroid hormone	Homo sapiens	166-169
8274878-1	1993	We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	167-176	parathyroid hormone	Rattus norvegicus	59-62
7690968-0	1993	Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions.	Vitamin D	54-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-40
7690968-9	1993	This work has revealed that the cytochrome P-450 CYP27 may be important in the metabolism of vitamin D analogs used as drugs.	Vitamin D	93-102	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-48
8268047-1	1993	Resistance to the renal actions of parathyroid hormone (PTH) in pseudohypoparathyroidism (PsH) may be improved after treatment with vitamin D or its metabolites, but reports conflict.	Vitamin D	132-141	parathyroid hormone	Homo sapiens	35-54
8394128-6	1993	Transient transfection of osteosarcoma cells with a reporter vector containing a vitamin D responsive element derived from the rat osteocalcin gene yields equivalent transcriptional activation in the presence of either 1,25(OH)2D3 or OCT. Further experiments performed at various 1,25(OH)2D3 concentrations to assess the relationship between receptor phosphorylation and transcriptional activity in intact cells showed a positive correlation between these two parameters, indicating that the 1,25(OH)2D3 hormone stimulates VDR phosphorylation and transcriptional activation in parallel.	Vitamin D	81-90	bone gamma-carboxyglutamate protein	Rattus norvegicus	131-142
8213259-2	1993	1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the active hormonal form of vitamin D, induces the osteocalcin promoter through a vitamin D response element (VDRE), and glucocorticoids also repress the vitamin D-induced promoter.	Vitamin D	14-23	bone gamma-carboxyglutamate protein	Homo sapiens	92-103
8213259-2	1993	1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the active hormonal form of vitamin D, induces the osteocalcin promoter through a vitamin D response element (VDRE), and glucocorticoids also repress the vitamin D-induced promoter.	Vitamin D	69-78	bone gamma-carboxyglutamate protein	Homo sapiens	92-103
8213259-2	1993	1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the active hormonal form of vitamin D, induces the osteocalcin promoter through a vitamin D response element (VDRE), and glucocorticoids also repress the vitamin D-induced promoter.	Vitamin D	69-78	bone gamma-carboxyglutamate protein	Homo sapiens	92-103
8213259-8	1993	Repression of the osteocalcin promoter was compatible with a composite model involving both the nGRE site and glucocorticoid regulation of factors that bind the vitamin D response element.	Vitamin D	161-170	bone gamma-carboxyglutamate protein	Homo sapiens	18-29
8232320-0	1993	Down-regulation of calcitonin gene transcription by vitamin D requires two widely separated enhancer sequences.	Vitamin D	52-61	calcitonin related polypeptide alpha	Homo sapiens	19-29
8232320-1	1993	Transcription of the calcitonin (CT) gene is down-regulated by vitamin D in normal and transformed thyroid C cells.	Vitamin D	63-72	calcitonin related polypeptide alpha	Homo sapiens	21-31
8232320-1	1993	Transcription of the calcitonin (CT) gene is down-regulated by vitamin D in normal and transformed thyroid C cells.	Vitamin D	63-72	calcitonin related polypeptide alpha	Homo sapiens	33-35
8232320-12	1993	We conclude that a negative response element to vitamin D is located between nucleotides -920 and -829 in the CT 5" flanking DNA.	Vitamin D	48-57	calcitonin related polypeptide alpha	Homo sapiens	110-112
8344702-0	1993	Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937.	Vitamin D	28-37	interleukin 6	Homo sapiens	112-125
8390483-10	1993	These findings indicate that endogenously synthesized vitamin D3 travels in plasma almost exclusively on DBP, providing for a slower hepatic delivery of the vitamin D and the more sustained increase in plasma 25-hydroxycholecalciferol observed after depot, parenteral administration of vitamin D.	Vitamin D	54-63	D-box binding PAR bZIP transcription factor	Homo sapiens	105-108
8390483-10	1993	These findings indicate that endogenously synthesized vitamin D3 travels in plasma almost exclusively on DBP, providing for a slower hepatic delivery of the vitamin D and the more sustained increase in plasma 25-hydroxycholecalciferol observed after depot, parenteral administration of vitamin D.	Vitamin D	157-166	D-box binding PAR bZIP transcription factor	Homo sapiens	105-108
8475055-7	1993	These elements are present near key regulatory sites of the osteocalcin gene promoter, such as the principal steroid hormone (vitamin D)-responsive sequences.	Vitamin D	126-135	bone gamma-carboxyglutamate protein	Homo sapiens	60-71
8462452-6	1993	Modulation of TGF-beta action by vitamin D metabolites, also known to regulate endochondral differentiation, was examined.	Vitamin D	33-42	transforming growth factor beta 1	Homo sapiens	14-22
8462452-0	1993	Direct effects of transforming growth factor-beta on chondrocytes are modulated by vitamin D metabolites in a cell maturation-specific manner.	Vitamin D	83-92	transforming growth factor beta 1	Homo sapiens	18-49
8483256-5	1993	Intermittent and pharmacologically high levels of plasma calcitriol are reported to suppress the PTH secretion effectively and recently 22-oxacalcitriol, a new active vitamin D analogue, is found to suppress PTH secretion without increasing plasma calcium.	Vitamin D	167-176	parathyroid hormone	Homo sapiens	208-211
8502975-10	1993	Vitamin D regulates the synthesis of the vitamin K dependent bone protein osteocalcin, which is functionally abnormal in postmenopausal women.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	74-85
8385456-5	1993	Furthermore, we examined the effect of retinoid, vitamin D and thyroid hormone status on the gene expression of RXR alpha, beta and gamma.	Vitamin D	49-58	retinoid X receptor alpha	Rattus norvegicus	112-121
8457600-0	1993	The effects of vitamin D deficiency on proteoglycan and hyaluronate constituents of chick bone.	Vitamin D	15-24	versican	Gallus gallus	39-51
8457600-1	1993	The effect of vitamin D deficiency on proteoglycan and hyaluronate constituents of cortical diaphyseal chick bone was studied.	Vitamin D	14-23	versican	Gallus gallus	38-50
8381969-0	1993	Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.	Vitamin D	76-85	bone gamma-carboxyglutamate protein	Rattus norvegicus	43-54
8381969-7	1993	For example, in proliferating osteoblasts, a vitamin D receptor-antibody-sensitive complex is formed that is different from the DNA binding complex induced by vitamin D postproliferatively when the OC gene is transcribed.	Vitamin D	45-54	bone gamma-carboxyglutamate protein	Rattus norvegicus	198-200
1321435-0	1992	Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	123-134
8380156-9	1993	When tested in a COS-1 cell transfection assay system using a rat osteocalcin vitamin D responsive element coupled to a growth hormone reporter gene, 1 alpha,25-(OH)2DHT3 showed a biological activity only 10 times lower than 1 alpha,25-(OH)2D3.	Vitamin D	78-87	bone gamma-carboxyglutamate protein	Rattus norvegicus	66-77
8164616-3	1993	Net PTH-elicited AC (dPTH-AC) activation hence reflected individual vitamin D status.	Vitamin D	68-77	parathyroid hormone	Homo sapiens	4-7
1472030-7	1992	Our results represent the first demonstration of the effect of active vitamin D and corticosteroid on the expression of osteocalcin mRNA in bone in vivo.	Vitamin D	70-79	bone gamma-carboxyglutamate protein	Rattus norvegicus	120-131
1335319-6	1992	These results indicate that the vitamin D-resistance in Hyp mice is not caused by hypophosphatemia, per se, and may result from a fundamental molecular defect in vitamin D action at the intestine which could be related to ineffective up-regulation of VDR mRNA by 1,25(OH)2D3.	Vitamin D	32-41	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	56-59
1335319-6	1992	These results indicate that the vitamin D-resistance in Hyp mice is not caused by hypophosphatemia, per se, and may result from a fundamental molecular defect in vitamin D action at the intestine which could be related to ineffective up-regulation of VDR mRNA by 1,25(OH)2D3.	Vitamin D	162-171	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	56-59
1336301-2	1992	PDDR (formerly vitamin D dependency type I, VDD1) was recently mapped to human chromosome 12q14 by linkage analysis.	Vitamin D	15-24	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-4
1336301-2	1992	PDDR (formerly vitamin D dependency type I, VDD1) was recently mapped to human chromosome 12q14 by linkage analysis.	Vitamin D	15-24	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	44-48
1474331-4	1992	The level of "ectopic" transcription of the PTH gene in lymphoblastoid cells appeared to be resistant to the administration of both vitamin D and phorbol esters.	Vitamin D	132-141	parathyroid hormone	Homo sapiens	44-47
8454164-0	1993	Influence of calcium and vitamin D deficient diet on calcitonin gene expression in the ultimobranchial cells of the developing chicken.	Vitamin D	25-34	calcitonin	Gallus gallus	53-63
8377726-6	1993	We conclude that PTHrP(1-34) causes similar effects on bone, in organ cultures, to those caused by bPTH(1-34), namely an increase in both bone resorption and formation and a decrease in the vitamin D-stimulated BGP synthesis.	Vitamin D	190-199	bone gamma-carboxyglutamate protein	Rattus norvegicus	211-214
1336301-1	1992	We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism.	Vitamin D	36-45	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	175-179
1331703-6	1992	We conclude that vitamin D3 egress from the skin is not affected by elevated circulating vitamin D concentrations; thus, the cutaneous release of vitamin D is probably mediated by a protein such as DBP with a high carrying capacity for the vitamin.	Vitamin D	17-26	D-box binding PAR bZIP transcription factor	Homo sapiens	198-201
1492397-3	1992	Neonates, being born by these females with the nephrectomy, had vitamin D deficiency, which was manifested as a decrease in content of active vitamin D metabolites and minerals as well as an increase in activity of alkaline phosphatase and in the content of parathyroid hormone.	Vitamin D	64-73	parathyroid hormone	Rattus norvegicus	258-277
1353882-2	1992	Its synthesis is induced by calcitriol, the active hormonal form of vitamin D, through the vitamin D receptor and a specific vitamin D-responsive element in the osteocalcin gene promoter.	Vitamin D	68-77	bone gamma-carboxyglutamate protein	Homo sapiens	161-172
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	21-30	bone gamma-carboxyglutamate protein	Rattus norvegicus	55-66
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	21-30	bone gamma-carboxyglutamate protein	Rattus norvegicus	68-70
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	21-30	bone gamma-carboxyglutamate protein	Rattus norvegicus	277-279
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	203-212	bone gamma-carboxyglutamate protein	Rattus norvegicus	55-66
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	203-212	bone gamma-carboxyglutamate protein	Rattus norvegicus	68-70
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	203-212	bone gamma-carboxyglutamate protein	Rattus norvegicus	277-279
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	203-212	bone gamma-carboxyglutamate protein	Rattus norvegicus	55-66
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	203-212	bone gamma-carboxyglutamate protein	Rattus norvegicus	68-70
1321435-1	1992	The observation that vitamin D-mediated enhancement of osteocalcin (OC) gene expression is dependent on and reciprocally related to the level of basal gene expression suggests that an interaction of the vitamin D responsive element (VDRE) with basal regulatory elements of the OC gene promoter contributes to both basal and vitamin D-enhanced transcription.	Vitamin D	203-212	bone gamma-carboxyglutamate protein	Rattus norvegicus	277-279
1321435-3	1992	In addition, a vitamin D-responsive increase in OC gene transcription is accompanied by enhanced non-vitamin D receptor-mediated protein-DNA interactions in the "TATA" box region (nucleotides -44 to +23), which also contains a potential glucocorticoid responsive element.	Vitamin D	15-24	bone gamma-carboxyglutamate protein	Rattus norvegicus	48-50
1321435-7	1992	A model is presented for the contribution of both the VDRE and proximal promoter elements to the enhancement of OC gene transcription in response to vitamin D.	Vitamin D	149-158	bone gamma-carboxyglutamate protein	Rattus norvegicus	112-114
1623332-8	1992	We recommend that supplementation of active form of vitamin D, such as 1 alpha-hydroxyvitamin D3 or 1,25(OH)2D3, is important in CAPD patients, particularly those with elevated peritoneal loss of DBP and/or albumin.	Vitamin D	52-61	D-box binding PAR bZIP transcription factor	Homo sapiens	196-199
1597134-1	1992	1,25-Dihydroxyvitamin D3 (1,25D) regulates its own levels in circulation by affecting its rates of synthesis and degradation, 22-Oxacalcitriol (OCT), a vitamin D analog with low calcemic activity, decreases circulating PTH levels, one of the regulators of renal 1 alpha-hydroxylase, and stimulates vitamin D degradation in vitro.	Vitamin D	14-23	parathyroid hormone	Rattus norvegicus	219-222
1548347-4	1992	To address this question, we undertook to assess 24-hydroxylase function in patients with vitamin D-dependency rickets type I (VDDR-I), a Mendelian disorder of 1,25-(OH)2D synthesis attributable to a defect in renal 1-hydroxylase activity.	Vitamin D	90-99	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	127-133
1374401-1	1992	Vitamin D-binding protein (DBP), a member of a multigene family including alpha-fetoprotein (AFP) and albumin, is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells.	Vitamin D	172-181	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
1374401-1	1992	Vitamin D-binding protein (DBP), a member of a multigene family including alpha-fetoprotein (AFP) and albumin, is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells.	Vitamin D	172-181	alpha fetoprotein	Homo sapiens	93-96
1319251-12	1992	These results suggest that vitamin D metabolites modulate PA2 activity, change the composition of membrane phospholipids by altering fatty acid composition, and affect calcium transport.	Vitamin D	27-36	phospholipase A2 group IB	Homo sapiens	58-61
1319665-1	1992	The hypophosphatemic (Hyp) mouse is the murine homolog for human hypophosphatemic vitamin D-resistant rickets.	Vitamin D	82-91	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	4-20
1319665-1	1992	The hypophosphatemic (Hyp) mouse is the murine homolog for human hypophosphatemic vitamin D-resistant rickets.	Vitamin D	82-91	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	22-25
1319665-1	1992	The hypophosphatemic (Hyp) mouse is the murine homolog for human hypophosphatemic vitamin D-resistant rickets.	Vitamin D	82-91	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	65-81
1542030-3	1992	However, in the vitamin D-replete rat, administration of 1,25(OH)2D3 results in an induction of both calbindin and VDR mRNA in these tissues.	Vitamin D	16-25	calbindin 1	Rattus norvegicus	101-110
1539040-3	1992	On the other hand, vitamin D under all circumstances increased calbindin-D 9-kDa mRNA levels, with the greatest levels found in animals on a low calcium diet where little or no calcium is available for absorption.	Vitamin D	19-28	calbindin 1	Rattus norvegicus	63-72
1312945-0	1992	In vitro enzyme activation with calbindin-D28k, the vitamin D-dependent 28 kDa calcium binding protein.	Vitamin D	52-61	calbindin 1	Rattus norvegicus	32-41
1312945-1	1992	Purified porcine erythrocyte membrane Ca(2+)-ATPase and 3":5"-cyclic nucleotide phosphodiesterase were stimulated in a dose-dependent, saturable manner with the vitamin D-dependent calcium binding protein from rat kidney, calbindin-D28k (CaBP-D28k).	Vitamin D	161-170	calbindin 1	Rattus norvegicus	222-231
1570767-9	1992	Levels in parathyroidectomized (PTX) rats (n = 9) were undetectable, but renal insufficiency and vitamin D deficiency increased PTH to 587.4 +/- 141.3 pg/ml (n = 73) and 1662.0 +/- 137.8 (n = 27), respectively.	Vitamin D	97-106	parathyroid hormone	Rattus norvegicus	128-131
1315116-1	1992	The hypophosphatemic (Hyp) mouse is an animal model for human hypophosphatemic vitamin D-resistant rickets.	Vitamin D	79-88	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	4-20
1315116-1	1992	The hypophosphatemic (Hyp) mouse is an animal model for human hypophosphatemic vitamin D-resistant rickets.	Vitamin D	79-88	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	22-25
1315116-1	1992	The hypophosphatemic (Hyp) mouse is an animal model for human hypophosphatemic vitamin D-resistant rickets.	Vitamin D	79-88	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	62-78
1303956-6	1992	Six possible mechanisms may explain the cadmium-induced bone effects: (1) interference with parathyroid hormone (PTH) stimulation of vitamin D production in kidney cells; (2) reduced activity of kidney enzymes activating vitamin D; (3) increased excretion of calcium in urine; (4) reduced absorption of calcium from intestines; (5) direct interference with calcium incorporation into bone cells; and (6) direct interference with collagen production in bone cells.	Vitamin D	133-142	parathyroid hormone	Homo sapiens	92-111
1309841-7	1992	After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect.	Vitamin D	119-128	tumor necrosis factor	Rattus norvegicus	186-195
1309841-7	1992	After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect.	Vitamin D	119-128	interleukin 6	Rattus norvegicus	207-211
1309841-7	1992	After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect.	Vitamin D	119-128	bone gamma-carboxyglutamate protein	Rattus norvegicus	250-261
1309841-7	1992	After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect.	Vitamin D	119-128	interleukin 1 alpha	Rattus norvegicus	285-295
1309841-7	1992	After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect.	Vitamin D	119-128	interleukin 1 beta	Rattus norvegicus	297-306
1309841-7	1992	After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect.	Vitamin D	229-238	tumor necrosis factor	Rattus norvegicus	186-195
1488999-8	1992	The present investigation demonstrated (1) that intravenous administration of the 1-hydroxylated vitamin D metabolite 1 alpha(OH)D3 induced a significant decrease in circulating levels of biologically active intact PTH, and (2) that it was possible to maintain the marked suppression of PTH secretion by intravenous treatment of 1 alpha (OH)D3 for up to 2 years.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	215-218
1488999-8	1992	The present investigation demonstrated (1) that intravenous administration of the 1-hydroxylated vitamin D metabolite 1 alpha(OH)D3 induced a significant decrease in circulating levels of biologically active intact PTH, and (2) that it was possible to maintain the marked suppression of PTH secretion by intravenous treatment of 1 alpha (OH)D3 for up to 2 years.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	287-290
2059879-4	1991	The active vitamin D metabolite 1,25-dihydroxycholecalciferol [1,25(OH)2D3] slightly increased the IGF-I level, but the increase was not statistically significant.	Vitamin D	11-20	insulin like growth factor 1	Homo sapiens	99-104
1314319-10	1992	Analysis of nuclear antigen Ki-67 revealed that, of the vitamin D-treated cells that were fms-positive, a significant proportion (37%) were still cycling.	Vitamin D	56-65	marker of proliferation Ki-67	Homo sapiens	20-33
1660470-3	1991	In this report, we examine the nature of specific VDR DNA binding utilizing the vitamin D-responsive element derived from the human osteocalcin promoter.	Vitamin D	80-89	bone gamma-carboxyglutamate protein	Homo sapiens	132-143
1796753-8	1991	Intramuscular injections for 10 consecutive days to vitamin D-deficient chicks demonstrated a greater than or equal to 100-fold lower biologic activity of MC 903, MC 1147, and 1,25-(OH)2-16ene-23yne-D3 compared to that of 1 alpha,25-(OH)2D3 as evaluated by serum calcium and osteocalcin concentrations, as well as by duodenal calbindin D28K and bone calcium content.	Vitamin D	52-61	bone gamma-carboxyglutamate protein	Homo sapiens	275-286
1785378-5	1991	We have previously examined the human bone-specific gene osteocalcin as a model of the molecular mechanisms of vitamin D action in bone and have shown that induction of the osteocalcin gene by 1,25-(OH)2D3 is mediated through an unique and complex palindromic region of the promoter similar to but distinct from those of other steroid hormone-responsive elements.	Vitamin D	111-120	bone gamma-carboxyglutamate protein	Homo sapiens	57-68
1785378-5	1991	We have previously examined the human bone-specific gene osteocalcin as a model of the molecular mechanisms of vitamin D action in bone and have shown that induction of the osteocalcin gene by 1,25-(OH)2D3 is mediated through an unique and complex palindromic region of the promoter similar to but distinct from those of other steroid hormone-responsive elements.	Vitamin D	111-120	bone gamma-carboxyglutamate protein	Homo sapiens	173-184
1785378-6	1991	Using an osteosarcoma cell line permanently transfected with the vitamin D-responsive promoter of the human osteocalcin gene linked to a "reporter" gene, we have shown that there is a dose-dependent induction of CAT activity by 1,25-(OH)2D3 and that the potencies of vitamin D metabolites and analogs are comparable to those found in other vitamin D bioassays.	Vitamin D	65-74	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
1785378-6	1991	Using an osteosarcoma cell line permanently transfected with the vitamin D-responsive promoter of the human osteocalcin gene linked to a "reporter" gene, we have shown that there is a dose-dependent induction of CAT activity by 1,25-(OH)2D3 and that the potencies of vitamin D metabolites and analogs are comparable to those found in other vitamin D bioassays.	Vitamin D	267-276	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
1785378-6	1991	Using an osteosarcoma cell line permanently transfected with the vitamin D-responsive promoter of the human osteocalcin gene linked to a "reporter" gene, we have shown that there is a dose-dependent induction of CAT activity by 1,25-(OH)2D3 and that the potencies of vitamin D metabolites and analogs are comparable to those found in other vitamin D bioassays.	Vitamin D	267-276	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
1785378-7	1991	Furthermore, vitamin D analogs, including MC-903, 22-oxa-1,25-(OH)2D3, and delta 22-1,25S,26-trihydroxyvitamin D3, which effect cellular differentiation but lack hypercalcemic activity in vivo, exhibit osteocalcin promoter inductive actions virtually identical to those of 1,25-(OH)2D3.	Vitamin D	13-22	bone gamma-carboxyglutamate protein	Homo sapiens	202-213
1924097-4	1991	Proliferation and differentiation of cartilage cells (i.e., chondrocytes) as studied mostly in culture, is regulated by various endocrine, paracrine, and autocrine agents such as growth hormone, insulin-like growth factor-I (IGF-I), transforming growth factor (TGE-beta), and vitamin D metabolites (1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol).	Vitamin D	276-285	insulin like growth factor 1	Homo sapiens	195-223
2067203-7	1991	A synthetic analogue of vitamin D, 22-oxa-1,25(OH)2D3, also suppressed PTH mRNA to normal levels, but without hypercalcemia.	Vitamin D	24-33	parathyroid hormone	Rattus norvegicus	71-74
1466160-4	1992	The concentrations of two vitamin D-dependent calcium-binding proteins were also decreased: a low duodenal calbindin-D 9K concentration corresponding to the low intestinal active calcium absorption and a low serum osteocalcin concentration, corresponding to a low bone formation and highly correlated with serum IGF-I concentration.	Vitamin D	26-35	bone gamma-carboxyglutamate protein	Rattus norvegicus	214-225
1795014-5	1991	The NMP binding domain in the osteocalcin gene promoter resides contiguous to the vitamin D responsive element.	Vitamin D	82-91	bone gamma-carboxyglutamate protein	Homo sapiens	30-41
1795014-6	1991	Together with gene and transcription factor localization, a model is proposed whereby nuclear matrix-associated structural constraints on conformation of the osteocalcin gene promoter facilitates vitamin D responsiveness mediated by cooperativity at multiple regulatory elements.	Vitamin D	196-205	bone gamma-carboxyglutamate protein	Homo sapiens	158-169
1661245-6	1991	The retinoic acid response element (RARE) for the rat growth hormone gene is also a thyroid hormone response element (TRE), and the AP-1 binding site of the human osteocalcin promoter is also a vitamin D response element (VDRE) and a RARE.	Vitamin D	194-203	bone gamma-carboxyglutamate protein	Homo sapiens	163-174
1664043-1	1991	The interaction of the vitamin D receptor with a vitamin D-responsive element (VDRE) derived from the human osteocalcin promoter in vitro has been shown to require a nuclear accessory factor (NAF) derived from monkey kidney cells.	Vitamin D	23-32	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
1664043-1	1991	The interaction of the vitamin D receptor with a vitamin D-responsive element (VDRE) derived from the human osteocalcin promoter in vitro has been shown to require a nuclear accessory factor (NAF) derived from monkey kidney cells.	Vitamin D	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
1656468-7	1991	Mutation of Ser-51 markedly inhibited transcriptional activation by the vitamin D hormone, suggesting that phosphorylation of Ser-51 by PKC could play a significant role in vitamin D-dependent transcriptional activation.	Vitamin D	72-81	proline rich transmembrane protein 2	Homo sapiens	136-139
1656468-7	1991	Mutation of Ser-51 markedly inhibited transcriptional activation by the vitamin D hormone, suggesting that phosphorylation of Ser-51 by PKC could play a significant role in vitamin D-dependent transcriptional activation.	Vitamin D	173-182	proline rich transmembrane protein 2	Homo sapiens	136-139
1687883-1	1991	Vitamin D-dependent rickets (VDD1) is an autosomal recessive disorder that was recognized in Saguenay-Lac-St-Jean (SLSJ) in 1970.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-33
1757481-0	1991	Influence of dexamethasone on the vitamin D-mediated regulation of osteocalcin gene expression.	Vitamin D	34-43	bone gamma-carboxyglutamate protein	Rattus norvegicus	67-78
1757481-3	1991	However, dexamethasone significantly inhibits these parameters of the vitamin D-induced upregulation of osteocalcin gene expression in both proliferating and in confluent ROS 17/2.8 cells.	Vitamin D	70-79	bone gamma-carboxyglutamate protein	Rattus norvegicus	104-115
1757481-4	1991	In this study, we observed that the extent to which abrogation of the vitamin D response occurs is dependent on basal levels of osteocalcin gene expression as reflected by a complete inhibition of the vitamin D-induced upregulation in a ROS 17/2.8K subline with low basal expression and only a partial reduction of the vitamin D stimulation in a ROS 17/2.8C subline with eightfold higher levels of basal expression.	Vitamin D	70-79	bone gamma-carboxyglutamate protein	Rattus norvegicus	128-139
1757481-4	1991	In this study, we observed that the extent to which abrogation of the vitamin D response occurs is dependent on basal levels of osteocalcin gene expression as reflected by a complete inhibition of the vitamin D-induced upregulation in a ROS 17/2.8K subline with low basal expression and only a partial reduction of the vitamin D stimulation in a ROS 17/2.8C subline with eightfold higher levels of basal expression.	Vitamin D	201-210	bone gamma-carboxyglutamate protein	Rattus norvegicus	128-139
1757481-4	1991	In this study, we observed that the extent to which abrogation of the vitamin D response occurs is dependent on basal levels of osteocalcin gene expression as reflected by a complete inhibition of the vitamin D-induced upregulation in a ROS 17/2.8K subline with low basal expression and only a partial reduction of the vitamin D stimulation in a ROS 17/2.8C subline with eightfold higher levels of basal expression.	Vitamin D	201-210	bone gamma-carboxyglutamate protein	Rattus norvegicus	128-139
1757481-6	1991	The complexity of the glucocorticoid effect on vitamin D-mediated transcriptional properties of the osteocalcin gene is indicated by persistence of sequence-specific protein-DNA interactions at two principal osteocalcin gene promoter regulatory elements, the osteocalcin (CCAAT) box which modulates basal level of transcription, and the vitamin D responsive element, where vitamin D-mediated enhancement of osteocalcin gene transcription is controlled.	Vitamin D	47-56	bone gamma-carboxyglutamate protein	Rattus norvegicus	100-111
1757481-6	1991	The complexity of the glucocorticoid effect on vitamin D-mediated transcriptional properties of the osteocalcin gene is indicated by persistence of sequence-specific protein-DNA interactions at two principal osteocalcin gene promoter regulatory elements, the osteocalcin (CCAAT) box which modulates basal level of transcription, and the vitamin D responsive element, where vitamin D-mediated enhancement of osteocalcin gene transcription is controlled.	Vitamin D	47-56	bone gamma-carboxyglutamate protein	Rattus norvegicus	208-219
1757481-6	1991	The complexity of the glucocorticoid effect on vitamin D-mediated transcriptional properties of the osteocalcin gene is indicated by persistence of sequence-specific protein-DNA interactions at two principal osteocalcin gene promoter regulatory elements, the osteocalcin (CCAAT) box which modulates basal level of transcription, and the vitamin D responsive element, where vitamin D-mediated enhancement of osteocalcin gene transcription is controlled.	Vitamin D	47-56	bone gamma-carboxyglutamate protein	Rattus norvegicus	208-219
1757481-6	1991	The complexity of the glucocorticoid effect on vitamin D-mediated transcriptional properties of the osteocalcin gene is indicated by persistence of sequence-specific protein-DNA interactions at two principal osteocalcin gene promoter regulatory elements, the osteocalcin (CCAAT) box which modulates basal level of transcription, and the vitamin D responsive element, where vitamin D-mediated enhancement of osteocalcin gene transcription is controlled.	Vitamin D	47-56	bone gamma-carboxyglutamate protein	Rattus norvegicus	208-219
1757481-6	1991	The complexity of the glucocorticoid effect on vitamin D-mediated transcriptional properties of the osteocalcin gene is indicated by persistence of sequence-specific protein-DNA interactions at two principal osteocalcin gene promoter regulatory elements, the osteocalcin (CCAAT) box which modulates basal level of transcription, and the vitamin D responsive element, where vitamin D-mediated enhancement of osteocalcin gene transcription is controlled.	Vitamin D	337-346	bone gamma-carboxyglutamate protein	Rattus norvegicus	100-111
1757481-6	1991	The complexity of the glucocorticoid effect on vitamin D-mediated transcriptional properties of the osteocalcin gene is indicated by persistence of sequence-specific protein-DNA interactions at two principal osteocalcin gene promoter regulatory elements, the osteocalcin (CCAAT) box which modulates basal level of transcription, and the vitamin D responsive element, where vitamin D-mediated enhancement of osteocalcin gene transcription is controlled.	Vitamin D	337-346	bone gamma-carboxyglutamate protein	Rattus norvegicus	100-111
1936526-10	1991	In the absence of calcium transport, cathepsin B-specific activity was enhanced in whole homogenates, endocytic vesicles, and a lysosomal fraction prepared from intestinal epithelium of 1,25(OH)2D3-treated chicks, relative to vitamin D-deficient controls.	Vitamin D	226-235	cathepsin B	Gallus gallus	37-48
1936526-12	1991	After 30 min of calcium transport, endocytic vesicles prepared from either vitamin D-deficient or 1,25(OH)2D3-treated birds had recovered cathepsin B activity to pretransport levels.	Vitamin D	75-84	cathepsin B	Gallus gallus	138-149
2023915-7	1991	We conclude that vitamin D deficiency reduces deposition of TGF-beta in rat bone and that diminished skeletal TGF-beta could contribute to the previously observed decrease in osteoinduction in implants from -D rat bone.	Vitamin D	17-26	transforming growth factor, beta 1	Rattus norvegicus	60-68
1864858-0	1991	The cellular and extracellular distribution of osteocalcin and dentin phosphoprotein in teeth of vitamin D-deficient rats.	Vitamin D	97-106	bone gamma-carboxyglutamate protein	Rattus norvegicus	47-58
2009668-13	1991	The synthesis and distribution of calbindin-D9k in normal and rachitic normal bone and cartilage indicate that vitamin D has a direct action on mineralizing tissues.	Vitamin D	111-120	S100 calcium binding protein G	Homo sapiens	34-47
2072223-7	1991	The decline in calbindin-D9K may indicate that the active vitamin D dependent intestinal calcium absorption decreases during childhood.	Vitamin D	58-67	S100 calcium binding protein G	Homo sapiens	15-28
2065499-3	1991	Two such treatments, sodium fluoride and vitamin D administration increase osteocalcin levels.	Vitamin D	41-50	bone gamma-carboxyglutamate protein	Homo sapiens	75-86
2065499-8	1991	A significant osteocalcin increase was observed in the control groups (p less than 0.001); similar significance was observed in the sodium fluoride group, whereas a lower significance (p less than 0.01) was observed in the vitamin D group.	Vitamin D	223-232	bone gamma-carboxyglutamate protein	Homo sapiens	14-25
1999147-2	1991	Recently, we observed that Hyp and Gy mice, murine homologs of X-linked hypophosphatemic rickets, exhibit similarly disparate regulation of vitamin D metabolism.	Vitamin D	140-149	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	27-30
1742505-10	1991	We think that the low osteocalcin levels observed in cirrhotics may be a consequence of "hepatic osteodystrophy" due to low vitamin D and calcium plasma levels.	Vitamin D	124-133	bone gamma-carboxyglutamate protein	Homo sapiens	22-33
1864858-11	1991	These data suggest that vitamin D acts directly on odontogenic cells at various synthetic (osteocalcin) or secretory (phosphoprotein) levels indicating that odontoblasts are target-cells for vitamin D.	Vitamin D	24-33	bone gamma-carboxyglutamate protein	Rattus norvegicus	91-102
1997523-2	1991	Since the PTH-vitamin D endocrine system is a major regulator of calcium metabolism and bone turnover, this cross-sectional study examined the relationship of radial and lumbar bone density to vitamin D metabolite and PTH concentrations and to calcium intake and excretion in 67 white and 70 black highly comparable, healthy, premenopausal women.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	10-13
1653893-0	1991	The vitamin D-responsive element in the rat bone Gla protein gene is an imperfect direct repeat that cooperates with other cis-elements in 1,25-dihydroxyvitamin D3- mediated transcriptional activation.	Vitamin D	4-13	bone gamma-carboxyglutamate protein	Rattus norvegicus	44-60
1985037-1	1991	A myosinlike 105-110-kilodalton calmodulin-binding protein, brush border myosin I, found in the intestinal brush border has been linked to two seemingly disparate but possibly interacting functions of the brush border, namely, microvillar motility and vitamin D regulated calcium transport.	Vitamin D	252-261	IQ motif containing J	Homo sapiens	32-58
1993948-0	1991	Hypomagnesemia and the parathyroid hormone-vitamin D endocrine system in children with insulin-dependent diabetes mellitus: effects of magnesium administration.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	23-42
1993948-1	1991	Because insulin-dependent diabetes mellitus is associated with altered electrolyte metabolism and a derangement of the parathyroid hormone (PTH)-vitamin D endocrine system, we studied 23 children with diabetes (age 9.4 +/- 2.5 years) and found lower serum values for total and ionized calcium, magnesium, intact PTH, calcitriol, and osteocalcin than in age- and sex-matched control subjects.	Vitamin D	145-154	parathyroid hormone	Homo sapiens	119-138
1677274-3	1991	Furthermore, the data embracing the hypothesis that the growth actions of hormone receptors that are homologous to the v-erbA oncogene (estrogens, progesterone, thyroid hormones, retinoic acid, and vitamin D) are mediated, in part, by modulating EGF-R and/or c-erbB-2 protooncogene transcription are reviewed.	Vitamin D	198-207	epidermal growth factor receptor	Homo sapiens	246-251
1677274-3	1991	Furthermore, the data embracing the hypothesis that the growth actions of hormone receptors that are homologous to the v-erbA oncogene (estrogens, progesterone, thyroid hormones, retinoic acid, and vitamin D) are mediated, in part, by modulating EGF-R and/or c-erbB-2 protooncogene transcription are reviewed.	Vitamin D	198-207	erb-b2 receptor tyrosine kinase 2	Homo sapiens	259-267
1835718-0	1991	Effects of vitamin D metabolites and bisphosphonates on fibronectin release from monocyte-derived macrophages.	Vitamin D	11-20	fibronectin 1	Homo sapiens	56-67
1900844-3	1991	Evidence is presented for a model which postulates that genes transcribed post-proliferatively are suppressed during cell growth by binding of the Fos/Jun protein complex to AP-1 promoter sites associated with vitamin D responsive elements of several genes encoding osteoblast phenotype markers (Type I collagen, alkaline phosphatase, osteocalcin).	Vitamin D	210-219	bone gamma-carboxyglutamate protein	Homo sapiens	335-346
2101404-0	1990	Osteocalcin is vitamin D-dependent during the perinatal period in the rat.	Vitamin D	15-24	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-11
2017266-0	1991	Acute effects of repetitive hemodialysis on circulating immunoreactive parathyroid hormone levels in uremic patients undergoing vitamin D (calcitriol) therapy.	Vitamin D	128-137	parathyroid hormone	Homo sapiens	71-90
1947853-2	1991	To study the effects of active vitamin D treatment on ALP, alphacalcidol (1-alpha-hydroxyvitamin D3), was given to patients with primary HPT as well as HPT secondary to chronic renal failure and also to healthy, euparathyroid subjects.	Vitamin D	31-40	alkaline phosphatase, placental	Homo sapiens	54-57
2174889-0	1990	The vitamin D-responsive element in the human osteocalcin gene.	Vitamin D	4-13	bone gamma-carboxyglutamate protein	Homo sapiens	46-57
2174889-2	1990	A vitamin D-responsive element (VDRE) locus within the 5" region of the human osteocalcin gene promoter contains a steroid response-like half-site immediately proximal to a consensus site for the AP-1 nuclear oncogene family.	Vitamin D	2-11	bone gamma-carboxyglutamate protein	Homo sapiens	78-89
2081010-4	1990	An inverse correlation existed between the change in vitamin D and the change in plasma renin activity (r = -0.765, P = .01).	Vitamin D	53-62	renin	Homo sapiens	88-93
2229313-6	1990	A negative correlation existed between PTH and 25-hydroxy-cholecalciferol (r = -0.49; P less than 0.05), the main circulating metabolite of vitamin D.	Vitamin D	140-149	parathyroid hormone	Homo sapiens	39-42
2101404-1	1990	The vitamin D-dependence of renal calbindin D-28K and osteocalcin during the perinatal period was studied in fetuses (days 18 and 21) and neonates (days 2, 12, 17 and 22) of rats fed either a standard diet (0.85% Ca-0.7% P; "high Ca-P diet" rats) or a mildly Ca-P restricted diet (0.2% Ca-0.2% P; "low Ca-P diet" rats).	Vitamin D	4-13	bone gamma-carboxyglutamate protein	Rattus norvegicus	54-65
2101404-8	1990	These studies indicate that osteocalcin is vitamin D-dependent in the fetal and neonatal rat.	Vitamin D	43-52	bone gamma-carboxyglutamate protein	Rattus norvegicus	28-39
2082223-0	1990	Seasonal fluctuations in parathyroid hormone in relation to vitamin D intake of postmenopausal women.	Vitamin D	60-69	parathyroid hormone	Homo sapiens	25-44
2082223-1	1990	Vitamin D deficiency in elderly living at northern latitudes results in increased serum parathyroid hormone (PTH) levels after winter.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	88-107
2124710-0	1990	Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.	Vitamin D	42-51	bone gamma-carboxyglutamate protein	Homo sapiens	104-115
2175914-5	1990	These studies suggest that the high-affinity interaction of the vitamin D receptor with the osteocalcin vitamin D response element in vitro requires both 1,25-dihydroxyvitamin D3 and an accessory protein derived from the mammalian cell nucleus.	Vitamin D	64-73	bone gamma-carboxyglutamate protein	Homo sapiens	92-103
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	bone gamma-carboxyglutamate protein	Homo sapiens	114-125
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	bone gamma-carboxyglutamate protein	Homo sapiens	169-180
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	bone gamma-carboxyglutamate protein	Homo sapiens	169-180
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	bone gamma-carboxyglutamate protein	Homo sapiens	169-180
2124710-7	1990	These results support a model in which coordinate occupancy of the AP-1 sites in the VDRE and OC box in proliferating osteoblasts may suppress both basal level and vitamin D-enhanced osteocalcin gene transcription as well as transcription of other genes associated with osteoblast differentiation--a phenomenon we describe as phenotype suppression.	Vitamin D	164-173	bone gamma-carboxyglutamate protein	Homo sapiens	183-194
2226314-5	1990	1,25(OH)2D3 also increased [Ca2+]i in ROS 24/1 cells, which are defective of receptors for the vitamin D metabolites.	Vitamin D	95-104	carbonic anhydrase 2	Rattus norvegicus	28-31
2285003-4	1990	The reduced 45Ca absorption in ATD occurred in the presence of normal plasma concentrations of PTH and vitamin D metabolites and the serum concentrations of calcium and aluminium were in the normal range.	Vitamin D	103-112	ATD	Homo sapiens	31-34
2226314-9	1990	In two thirds of the cells studied, a second addition of 1,25(OH)2D3 within 5 min to cells prestimulated with equimolar doses of the vitamin D metabolite resulted in a [Ca2+]i transient of higher amplitude than the first, a phenomenon occurring at all doses of the hormone, and associated with production of Ins(1, 4, 5)P3.	Vitamin D	133-142	carbonic anhydrase 2	Rattus norvegicus	169-172
2226314-11	1990	In conclusion, activation of the Ca2+ message system by vitamin D metabolites is a rapid, nongenomic effect; 1,25(OH)2D3 specifically activates both PLC and dihydropyridine-sensitive Ca2+ channels, and "primes" the cells to respond with an enhanced [Ca2+]i rise to a subsequent homologous stimulation; the presence of both the 1 alpha and 25 hydroxyl groups is necessary to express the full hormonal action of vitamin D on [Ca2+]i.	Vitamin D	56-65	carbonic anhydrase 2	Rattus norvegicus	33-36
2226314-11	1990	In conclusion, activation of the Ca2+ message system by vitamin D metabolites is a rapid, nongenomic effect; 1,25(OH)2D3 specifically activates both PLC and dihydropyridine-sensitive Ca2+ channels, and "primes" the cells to respond with an enhanced [Ca2+]i rise to a subsequent homologous stimulation; the presence of both the 1 alpha and 25 hydroxyl groups is necessary to express the full hormonal action of vitamin D on [Ca2+]i.	Vitamin D	410-419	carbonic anhydrase 2	Rattus norvegicus	33-36
2246328-0	1990	Vitamin D regulates transferrin receptor expression by bone marrow macrophage precursors.	Vitamin D	0-9	transferrin	Homo sapiens	20-31
2125401-0	1990	Alterations in vitamin D metabolites during treatment of Paget"s disease of bone with calcitonin or etidronate.	Vitamin D	15-24	calcitonin related polypeptide alpha	Homo sapiens	86-96
2173326-3	1990	PTH suppressed the Ca2+ pump activity in normocalcemic vitamin D-deficient rats.	Vitamin D	55-64	parathyroid hormone	Rattus norvegicus	0-3
2180972-2	1990	These studies suggest that this adaptive change in vitamin D metabolism is mediated through insulin-like growth factor-I (IGF-I) and/or insulin.	Vitamin D	51-60	insulin like growth factor 1	Homo sapiens	92-120
2212016-0	1990	Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat.	Vitamin D	86-95	parathyroid hormone	Rattus norvegicus	14-33
2212016-2	1990	We now report the effect of 3 and 8 wk of changes in dietary vitamin D and calcium on PTH mRNA levels.	Vitamin D	61-70	parathyroid hormone	Rattus norvegicus	86-89
2212016-3	1990	PTH mRNA levels were increased by 3 wk of calcium deficiency (five times), a vitamin D-deficient diet (two times), and combined deficiency (10 times), but not changed by high calcium.	Vitamin D	77-86	parathyroid hormone	Rattus norvegicus	0-3
2212016-4	1990	Vitamin D-deficient-diet rats" PTH mRNA did not decrease after a single large dose of 1,25(OH)2D3, but did decrease partially after repeated daily doses of 1,25(OH)2D3.	Vitamin D	0-9	parathyroid hormone	Rattus norvegicus	31-34
2212016-8	1990	Moreover, a calcium-deficient, more so than a vitamin D-deficient diet, amplifies the expression of the PTH gene, and vitamin D is necessary for an intact response of PTH mRNA to 1,25(OH)2D3 or calcium.	Vitamin D	46-55	parathyroid hormone	Rattus norvegicus	104-107
2212016-8	1990	Moreover, a calcium-deficient, more so than a vitamin D-deficient diet, amplifies the expression of the PTH gene, and vitamin D is necessary for an intact response of PTH mRNA to 1,25(OH)2D3 or calcium.	Vitamin D	118-127	parathyroid hormone	Rattus norvegicus	167-170
1971995-1	1990	Linkage analysis in French-Canadian families with vitamin D dependency type I (VDD1) demonstrated that the gene responsible for the disease is linked to polymorphic RFLP markers in the 12q14 region.	Vitamin D	50-59	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	79-83
2163713-10	1990	In vitamin D- and Pi-treated patients 1,25(OH)2D levels are further depressed, with a resultant increase in PTH values, and the development of tertiary hyperparathyroidism in a small number of patients.	Vitamin D	3-12	parathyroid hormone	Homo sapiens	108-111
2159384-1	1990	We present evidence that the vitamin D response element in the human osteocalcin gene confers responsiveness to the vitamin A metabolite, retinoic acid.	Vitamin D	29-38	bone gamma-carboxyglutamate protein	Homo sapiens	69-80
2387281-4	1990	The vitamin D status of 8-year-old Turkish, Moroccan and Caucasian children was assessed by measuring plasma concentrations of 25-OHD and parathyroid hormone (PTH) and related to the cumulated global sun radiation (CGSR).	Vitamin D	4-13	parathyroid hormone	Homo sapiens	138-157
2180972-2	1990	These studies suggest that this adaptive change in vitamin D metabolism is mediated through insulin-like growth factor-I (IGF-I) and/or insulin.	Vitamin D	51-60	insulin like growth factor 1	Homo sapiens	122-127
2180972-2	1990	These studies suggest that this adaptive change in vitamin D metabolism is mediated through insulin-like growth factor-I (IGF-I) and/or insulin.	Vitamin D	51-60	insulin	Homo sapiens	92-99
2308930-0	1990	Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	93-104
2365024-5	1990	Our data demonstrate that in elderly females with vitamin-D deficiency secondary hyperparathyroidism is associated with increased serum OC levels indicating an increased bone formation; these conditions might contribute to the bone disease of geriatric patients.	Vitamin D	50-59	bone gamma-carboxyglutamate protein	Homo sapiens	136-138
2308930-5	1990	We have also observed that vitamin D stimulation of osteocalcin gene expression results in a 5-fold increase in protein binding to the region of the osteocalcin box, a 24-nucleotide segment in the proximal promoter with a CCAAT motif as the central core.	Vitamin D	27-36	bone gamma-carboxyglutamate protein	Rattus norvegicus	52-63
2308930-5	1990	We have also observed that vitamin D stimulation of osteocalcin gene expression results in a 5-fold increase in protein binding to the region of the osteocalcin box, a 24-nucleotide segment in the proximal promoter with a CCAAT motif as the central core.	Vitamin D	27-36	bone gamma-carboxyglutamate protein	Rattus norvegicus	149-160
2308930-6	1990	Our results demonstrate protein-DNA interactions in a vitamin D-responsive element and in a second sequence, the osteocalcin box, both of which are involved in the physiologic regulation of the osteocalcin gene in response to 1,25-dihydroxyvitamin D3.	Vitamin D	54-63	bone gamma-carboxyglutamate protein	Rattus norvegicus	194-205
2222569-3	1990	The changes reported in calciotropic hormones, mainly vitamin D and parathyroid hormone, are observed due in part to a deficient intestinal absorption of vitamin D and an inadequate synthesis of its hepatic metabolite, although greater emphasis has been given to dietary deficiencies or lack of exposure to sun.	Vitamin D	154-163	parathyroid hormone	Homo sapiens	68-87
2308258-2	1990	The X-linked Hyp mouse is characterized by reduced phosphate transport and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis relative to normal, whereas the phosphate-deprived mouse exhibits elevated phosphate transport and vitamin D hormone synthesis.	Vitamin D	89-98	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	13-16
2191550-6	1990	Calbindin is present in both normal and tumoral islet cells, and might participate to the alteration of islet function encountered in vitamin D-deprived or repleted rats.	Vitamin D	134-143	calbindin 1	Rattus norvegicus	0-9
33798678-0	2021	Vitamin D decreases silencer methylation to downregulate renin gene expression.	Vitamin D	0-9	renin	Homo sapiens	57-62
1972874-8	1990	As one of the immunoregulators, vitamin D tends to stimulate the macrophage-natural killer system and suppress the lymphocyte system, stimulating TGF beta and TNF alpha activity.	Vitamin D	32-41	transforming growth factor beta 1	Homo sapiens	146-154
1972874-8	1990	As one of the immunoregulators, vitamin D tends to stimulate the macrophage-natural killer system and suppress the lymphocyte system, stimulating TGF beta and TNF alpha activity.	Vitamin D	32-41	tumor necrosis factor	Homo sapiens	159-168
2250626-7	1990	Basal calcium flow, in the absence of the cytosolic, vitamin D-dependent calcium-binding protein, CaBP, is only about 1/70 of the maximum rate, Vm, in the vitamin D-replete duodenum.	Vitamin D	53-62	S100 calcium binding protein G	Homo sapiens	98-102
2184443-6	1990	With regard to the intestinal epithelial system, the genomic effect of 1,25(OH)2D3 was shown several years ago when the de novo synthesis of a specific vitamin D-induced calcium-binding protein (CaBP, calbindin-D) was demonstrated.	Vitamin D	152-161	S100 calcium binding protein G	Homo sapiens	195-199
2744272-2	1989	One of the best-defined molecular markers of the action of vitamin D is a calcium-binding protein of Mr 28,000 called calbindin D-28 K (CaBP 28 K).	Vitamin D	59-68	calbindin 1	Rattus norvegicus	136-145
2744272-13	1989	In all stages, ameloblasts from vitamin-D-deficient rats appeared depleted of CaBP 28 K.	Vitamin D	32-41	calbindin 1	Rattus norvegicus	78-87
33798678-2	2021	Transcriptional regulation of REN has been linked to enhancer-promoter crosstalk, cAMP response element-binding protein (CREB), the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and a less well-characterized intronic silencer element.	Vitamin D	153-162	renin	Homo sapiens	30-33
33973916-8	2021	In general, body metrics (body mass index) or nutritional factors (serum vitamin D, glucose levels, and caffeine intake) were found to be associated with refractive error or myopia status; however, increased insulin levels were related to increased odds of having myopia.	Vitamin D	73-82	insulin	Homo sapiens	208-215
33818731-7	2021	Higher C-reactive protein (CRP) levels were seen in the vitamin D-deficient group (p = 0.013).	Vitamin D	56-65	C-reactive protein	Homo sapiens	7-25
33818731-7	2021	Higher C-reactive protein (CRP) levels were seen in the vitamin D-deficient group (p = 0.013).	Vitamin D	56-65	C-reactive protein	Homo sapiens	27-30
33819632-13	2021	Measurement of DBP is recommended when evaluating vitamin D status in patients with psoriasis.	Vitamin D	50-59	D-box binding PAR bZIP transcription factor	Homo sapiens	15-18
33819632-14	2021	High DBP levels in psoriasis imply a disturbed vitamin D pathway that warrants further investigation.	Vitamin D	47-56	D-box binding PAR bZIP transcription factor	Homo sapiens	5-8
33819632-2	2021	It has been proposed that the ability of vitamin D to exert anti-inflammatory effects might not depend solely on the concentration of serum 25(OH)D but also on the concentration of vitamin D-binding protein (DBP).	Vitamin D	41-50	D-box binding PAR bZIP transcription factor	Homo sapiens	208-211
33819632-3	2021	High concentrations of DBP might diminish vitamin D s biologic action.	Vitamin D	42-51	D-box binding PAR bZIP transcription factor	Homo sapiens	23-26
33807159-2	2021	We examined the cross-sectional association between biomarkers of vitamin D status and C-reactive protein (CRP) among postmenopausal women aged 53-81 years.	Vitamin D	66-75	C-reactive protein	Homo sapiens	87-105
33807159-2	2021	We examined the cross-sectional association between biomarkers of vitamin D status and C-reactive protein (CRP) among postmenopausal women aged 53-81 years.	Vitamin D	66-75	C-reactive protein	Homo sapiens	107-110
33800650-6	2021	Vitamin D supplementation appears to regulate not only lipid and mitochondrial muscle metabolism but also to have a direct effect on glucose metabolism and insulin driven signalling.	Vitamin D	0-9	insulin	Homo sapiens	156-163
33810258-1	2021	BACKGROUND: Seven weeks of high-dose vitamin D treatment decreases intestinal IL17A and IFN-gamma mRNA expression in active Crohn"s disease (CD).	Vitamin D	37-46	interferon gamma	Homo sapiens	88-97
33774081-10	2021	Agents that suppress PTH (vitamin D analogues and calcimimetics) are used to treat hyperparathyroid bone disease.	Vitamin D	26-35	parathyroid hormone	Homo sapiens	21-24
33762518-0	2021	Alkaline phosphatase in pediatric patients with genu varum caused by vitamin D-deficient rickets.	Vitamin D	69-78	alkaline phosphatase, placental	Homo sapiens	0-20
33762518-9	2021	These findings are important and informative for pediatricians to understand the significance of the serum ALP level in pediatric patients with genu varum caused by vitamin D deficiency.	Vitamin D	165-174	alkaline phosphatase, placental	Homo sapiens	107-110
34696918-0	2022	Vitamin D decreases expression of NLRP1 and NLRP3 ninflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide.	Vitamin D	0-9	NLR family pyrin domain containing 1	Homo sapiens	34-39
34929622-4	2022	In this article Vitamin D optical properties are studied by density functional theory calculations, compared to reported data, and the new calculated and measured D2 and D3 optical absorption lines are presented, as well as the calculations compared with spectral measurements of optical transmission, FTIR ATR and Raman spectra.	Vitamin D	16-25	ATR serine/threonine kinase	Homo sapiens	307-310
34637962-0	2022	Fabrication of electrochemical immunosensor based on GCN-beta-CD/Au nanocomposite for the monitoring of vitamin D deficiency.	Vitamin D	104-113	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	57-64
34600161-1	2022	OBJECTIVE: To establish serological biomarker models composed of bone turnover markers (BTMs), vitamin D (Vit D), and estradiol (E2) and to explore their auxiliary diagnostic value in girls with idiopathic central precocious puberty (ICPP).	Vitamin D	95-104	vitrin	Homo sapiens	106-109
34508903-3	2022	The aim of this study was to assess the relationship between aldosterone levels and PTH-vitamin D-calcium axis in a cohort of patients with PA, compared to patients with non-secreting adrenocortical tumors in conditions of vitamin D sufficiency.	Vitamin D	88-97	parathyroid hormone	Homo sapiens	84-87
2365024-0	1990	Increased serum osteocalcin levels in elderly females with vitamin D deficiency.	Vitamin D	59-68	bone gamma-carboxyglutamate protein	Homo sapiens	16-27
33803480-4	2021	Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression.	Vitamin D	9-18	estrogen receptor 1	Homo sapiens	91-108
33803480-4	2021	Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression.	Vitamin D	9-18	erb-b2 receptor tyrosine kinase 2	Homo sapiens	222-227
33762946-0	2021	A Prospective Study of Vitamin D Supplement in Thyroidectomy Patients Based on Relative Decline of Parathyroid Hormone.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	99-118
33762946-4	2021	Aim: We conducted a prospective study to evaluate the effect of vitamin D supplement (calcitriol) on high-risk hypocalcemia patients based on relative decline of parathyroid hormone (RDP).	Vitamin D	64-73	parathyroid hormone	Homo sapiens	162-181
33761087-4	2021	In this study, we evaluated the mRNA expression of VDR and PDIA3 involved in vitamin D signaling in cell lines representing different stages of PCa (PNT2, P4E6, LNCaP, DU145 and PC3).	Vitamin D	77-86	protein disulfide isomerase family A member 3	Homo sapiens	59-64
33504033-0	2021	Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	0-19
32795167-9	2022	Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.	Vitamin D	100-109	insulin	Homo sapiens	273-280
25815174-7	2015	Calcitonin is known to stimulate renal 1,25 (OH)2 vitamin D (1,25D) production at a site in the proximal tubule different from parathyroid hormone and hypophosphatemia.	Vitamin D	50-59	calcitonin related polypeptide alpha	Homo sapiens	0-10
24943330-5	2014	RESULTS: Neonatal mice that had in utero and early-life vitamin D deficiency had significantly increased pulmonary CD3(+) CD4(+) T1ST2(+) cells and reduced CD4(+) IL-10(+) cells.	Vitamin D	56-65	interleukin 10	Mus musculus	163-168
24943330-9	2014	CONCLUSION: Peri-natal vitamin D deficiency alone has immunomodulatory effects including Th2 skewing and reduced IL-10-secreting T regulatory cells, exaggerated with additional allergen exposure.	Vitamin D	23-32	interleukin 10	Mus musculus	113-118
23385553-0	2013	Effects of vitamin D(2) supplementation on insulin sensitivity and metabolic parameters in metabolic syndrome patients.	Vitamin D	11-20	insulin	Homo sapiens	43-50
23662440-9	2012	Proper supplementation with vitamin D increase the concentration of substrate for local 1,25(OH)2D synthesis 25(OH)D, which directly suppress PTH, increase Klotho, and decrease FGF-23 by proanabolic action on bone.	Vitamin D	28-37	parathyroid hormone	Homo sapiens	142-145
21183606-5	2011	Surprisingly, JNK2 loss was synergistic with a Western-style high-risk diet (high fat and phosphate and low calcium and vitamin D) to accelerate intestinal tumorigenesis.	Vitamin D	120-129	mitogen-activated protein kinase 9	Mus musculus	14-18
15033766-0	2003	Vitamin D enhances caspase-dependent and independent TNF-induced breast cancer cell death: the role of reactive oxygen species.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	53-56
15033766-1	2003	Calcitriol, the hormonal form of vitamin D, enhanced TNF-induced cytotoxicity in MCF-7 breast cancer cells.	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	53-56
34649031-5	2022	This review showed that vitamin d-fortified bread is a promising vehicle for fortification strategy effects, leading to increased serum concentrations of 25(OH)D and decreased parathyroid hormone.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	176-195
34843870-13	2022	Serum DBP concentration is an important predictor of vitamin D kinetics, and more research is needed to fully understand the significance of elevated DBP concentration during pregnancy.	Vitamin D	53-62	D-box binding PAR bZIP transcription factor	Homo sapiens	6-9
34843870-13	2022	Serum DBP concentration is an important predictor of vitamin D kinetics, and more research is needed to fully understand the significance of elevated DBP concentration during pregnancy.	Vitamin D	53-62	D-box binding PAR bZIP transcription factor	Homo sapiens	150-153
34678476-0	2022	Association between Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome and impact of long-term continuous positive airway pressure therapy on biomarker levels.	Vitamin D	38-47	interleukin 6	Homo sapiens	20-33
34894486-11	2022	CONCLUSIONS: The findings from this study support a role for UV exposure and vitamin D in the etiology of ER- breast cancer.	Vitamin D	77-86	estrogen receptor 1	Homo sapiens	106-108
34779254-0	2022	Vitamin D supplementation induces CatG-mediated CD4+ T cell inactivation and restores pancreatic beta-cell function in mice with type 1 diabetes.	Vitamin D	0-9	cathepsin G	Mus musculus	34-38
34779254-2	2022	In this study, we aimed to explore the regulatory effects of Vitamin D (VD) supplementation on pancreatic beta-cell function by altering the expression of bioinformatically identified cathepsin G (CatG) in T1D model mice.	Vitamin D	61-70	cathepsin G	Mus musculus	184-195
34779254-2	2022	In this study, we aimed to explore the regulatory effects of Vitamin D (VD) supplementation on pancreatic beta-cell function by altering the expression of bioinformatically identified cathepsin G (CatG) in T1D model mice.	Vitamin D	61-70	cathepsin G	Mus musculus	197-201
34973430-0	2022	Immunomodulatory effect of vitamin D on the STATs and transcription factors of CD4+ T cell subsets in pregnant women with preeclampsia.	Vitamin D	27-36	CD4 molecule	Homo sapiens	79-82
34696918-0	2022	Vitamin D decreases expression of NLRP1 and NLRP3 ninflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide.	Vitamin D	0-9	NLR family pyrin domain containing 3	Homo sapiens	44-49
34696918-1	2022	This study aimed to evaluate the immunomodulatory effect of vitamin D (VD) on the NLRP1 and NLRP3 inflammasomes in placental explants from preeclamptic (PE) and normotensive (NT) pregnant women.	Vitamin D	60-69	NLR family pyrin domain containing 1	Homo sapiens	82-87
34696918-1	2022	This study aimed to evaluate the immunomodulatory effect of vitamin D (VD) on the NLRP1 and NLRP3 inflammasomes in placental explants from preeclamptic (PE) and normotensive (NT) pregnant women.	Vitamin D	60-69	NLR family pyrin domain containing 3	Homo sapiens	92-97
34490953-7	2022	The increased risk of low muscle strength was correlated to a lower level of vitamin D (adjusted OR, 0.58) accompanied by an elevation in serum Ang II level.	Vitamin D	77-86	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	144-150
34563663-8	2022	Futhermore, IL-1beta functioning as NF-kappaB activator abolished the suppression of NF-kappaB activation, DMT1 induction and the attenuation of apoptosis as a consequence of vitamin D incubation.	Vitamin D	175-184	interleukin 1 alpha	Rattus norvegicus	12-20
34861286-16	2022	SIGNIFICANCE: Pirfenidone and vitamin D demonstrated a viable approach to suppress the nephrotoxicity initiated by doxorubicin through inhibiting the JNK1 and MCP-1 pathways.	Vitamin D	30-39	mast cell protease 1	Mus musculus	159-164
34492624-2	2022	Previous studies have examined the association between the mean vitamin D (Vit D) concentration of each country and COVID-19 infection and mortality rate in European countries.	Vitamin D	64-73	vitrin	Homo sapiens	75-78
34597852-0	2022	Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature.	Vitamin D	0-9	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	136-140
34597852-0	2022	Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature.	Vitamin D	0-9	inhibitor of DNA binding 3, HLH protein	Homo sapiens	141-144
34597852-6	2022	Low vitamin D levels were associated with a high CD8/Treg ratio; increased serum levels and T-cell production of proinflammatory cytokines; and a gene expression signature of unrestrained T-cell proliferation and epigenetic modulation through the PRC2/EZH2 complex.	Vitamin D	4-13	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	252-256
34597852-7	2022	Immunophenotyping confirmed a strong association between high levels of vitamin D and an activated EZH2 signature, characterized by overexpression of ID3, which has a role in effector T-cell differentiation.	Vitamin D	72-81	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	99-103
34597852-7	2022	Immunophenotyping confirmed a strong association between high levels of vitamin D and an activated EZH2 signature, characterized by overexpression of ID3, which has a role in effector T-cell differentiation.	Vitamin D	72-81	inhibitor of DNA binding 3, HLH protein	Homo sapiens	150-153
34597852-8	2022	Our findings demonstrate the critical role of vitamin D in modulating T-cell function in human GVHD and identify a previously undescribed interaction with EZH2 and ID3 which may impact effector differentiation and has implications to cell therapies and other forms of cancer immunotherapy.	Vitamin D	46-55	inhibitor of DNA binding 3, HLH protein	Homo sapiens	164-167
34969788-1	2021	Vitamin D-resistant rickets shows the resistance to vitamin D (Vit-D) therapy, which traditionally works well in cases with deficiency rickets.	Vitamin D	0-9	vitrin	Homo sapiens	63-66
34969788-1	2021	Vitamin D-resistant rickets shows the resistance to vitamin D (Vit-D) therapy, which traditionally works well in cases with deficiency rickets.	Vitamin D	52-61	vitrin	Homo sapiens	63-66
34886758-7	2021	The immune function of vitamin D is explained in part by the presence of its receptor (VDR) and its activating enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) in immune cells.	Vitamin D	23-32	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	158-165
34937520-0	2021	Vitamin D decreases cell death and inflammation in human umbilical vein endothelial cells and placental explants from pregnant women with preeclampsia cultured with TNF-alpha.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	165-174
34956363-0	2021	Vitamin D Insufficiency Predicts Susceptibility of Parathyroid Hormone Reduction after Total Thyroidectomy in Thyroid Cancer Patients.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	51-70
34950730-0	2021	Prevalence of Vitamin D Deficiency and Its Association with Insulin Resistance in Obese Women with Normal Fasting Glucose.	Vitamin D	14-23	insulin	Homo sapiens	60-67
34950730-12	2021	Prevalence of insulin resistance, though negatively correlated with vitamin D, could be better explained by BMI and PTH levels.	Vitamin D	68-77	insulin	Homo sapiens	14-21
34950730-12	2021	Prevalence of insulin resistance, though negatively correlated with vitamin D, could be better explained by BMI and PTH levels.	Vitamin D	68-77	parathyroid hormone	Homo sapiens	116-119
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interferon alpha 1	Homo sapiens	101-105
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	tumor necrosis factor	Homo sapiens	108-117
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interleukin 6	Homo sapiens	129-133
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	C-reactive protein	Homo sapiens	173-191
34960039-0	2021	The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study.	Vitamin D	4-13	insulin	Homo sapiens	86-93
34960039-2	2021	The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages.	Vitamin D	134-143	insulin	Homo sapiens	75-82
34966771-11	2021	According to the multivariable analysis, young age, female gender, low albumin level, high parathyroid hormone (PTH) level, and high sequential organ failure assessment (SOFA) score were significantly associated risk factors for vitamin D deficiency.	Vitamin D	229-238	albumin	Homo sapiens	71-78
34966771-11	2021	According to the multivariable analysis, young age, female gender, low albumin level, high parathyroid hormone (PTH) level, and high sequential organ failure assessment (SOFA) score were significantly associated risk factors for vitamin D deficiency.	Vitamin D	229-238	parathyroid hormone	Homo sapiens	91-110
34966771-11	2021	According to the multivariable analysis, young age, female gender, low albumin level, high parathyroid hormone (PTH) level, and high sequential organ failure assessment (SOFA) score were significantly associated risk factors for vitamin D deficiency.	Vitamin D	229-238	parathyroid hormone	Homo sapiens	112-115
34966771-15	2021	Age, gender, albumin level, PTH level, and SOFA score were significantly associated with vitamin D deficiency in these patients.	Vitamin D	89-98	parathyroid hormone	Homo sapiens	28-31
34893075-1	2021	BACKGROUND: Pregnancy is a high-risk period for vitamin D (Vit D) deficiency, and there is a direct relationship between Vit D deficiency during this period and maternal and fetal complications.	Vitamin D	48-57	vitrin	Homo sapiens	59-62
34944690-0	2021	Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein.	Vitamin D	0-9	thioredoxin interacting protein	Homo sapiens	111-142
34948669-1	2021	Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency.	Vitamin D	314-323	parathyroid hormone	Homo sapiens	126-145
34948669-1	2021	Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency.	Vitamin D	314-323	parathyroid hormone	Homo sapiens	147-150
34948669-1	2021	Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency.	Vitamin D	314-323	parathyroid hormone	Homo sapiens	260-263
34947912-3	2021	These IL-6 levels could be lowered with an adequate dietary intake of vitamin D.	Vitamin D	70-79	interleukin 6	Homo sapiens	6-10
34947912-4	2021	The objective of the study was to determine the level of vitamin D ingested in a sample of patients with MS in the Valencian region (Spain), to establish the vitamin sources, and the possible link between the intake of vitamin D and the pathogenesis of the disease through a relationship with the level of IL-6.	Vitamin D	57-66	interleukin 6	Homo sapiens	306-310
34947912-4	2021	The objective of the study was to determine the level of vitamin D ingested in a sample of patients with MS in the Valencian region (Spain), to establish the vitamin sources, and the possible link between the intake of vitamin D and the pathogenesis of the disease through a relationship with the level of IL-6.	Vitamin D	219-228	interleukin 6	Homo sapiens	306-310
34947912-8	2021	(3) Results: The results show a low intake of vitamin D, which is significantly and negatively related to the intake of proteins of vegetable origin, which are consumed in less quantity than proteins of animal origin, and significantly and negatively related with the high blood levels of IL-6, possibly as a consequence of the high intake of fats, mainly unsaturated.	Vitamin D	46-55	interleukin 6	Homo sapiens	289-293
34947912-9	2021	(4) Conclusions: MS patients in the Valencian region ingest little vitamin D related to low intake of vegetable protein, which would explain the high levels of IL-6 linked to the high intake of mainly saturated fats.	Vitamin D	67-76	interleukin 6	Homo sapiens	160-164
34645272-4	2021	RESULTS: insulin and HOMA-IR levels were higher among women with vitamin D below adequate levels compared to those with adequate levels in pregnancy (p < 0.05).	Vitamin D	65-74	insulin	Homo sapiens	9-16
34645272-6	2021	Maternal vitamin D late in pregnancy was correlated with infant vitamin D levels at birth (r = 0.89; p < 0.01) and 4 months (r = 0.9; p = 0.04), and with glucose (r = 0.79; p = 0.03) and insulin (r = 0.83; p = 0.04) at 4 months.	Vitamin D	9-18	insulin	Homo sapiens	187-194
34881815-9	2021	Native thiol and total thiol levels negatively correlated with age and AGA duration, while disulfide levels only correlated with age.Albumin and native thiol levels were significantly lower in patients with low vitamin D levels (p = 0.040 and p = 0.021, respectively); however, total thiol and native thiol/total thiol ratio values were significantly higher.	Vitamin D	211-220	albumin	Homo sapiens	133-140
34872610-0	2021	Combined effects of vitamin D supplementation and endurance exercise training on insulin resistance in newly diagnosed type 2 diabetes mellitus patients with vitamin D deficiency: study protocol for a randomized controlled trial.	Vitamin D	20-29	insulin	Homo sapiens	81-88
34872610-0	2021	Combined effects of vitamin D supplementation and endurance exercise training on insulin resistance in newly diagnosed type 2 diabetes mellitus patients with vitamin D deficiency: study protocol for a randomized controlled trial.	Vitamin D	158-167	insulin	Homo sapiens	81-88
34872610-1	2021	BACKGROUND: Although approximately 50% of Chinese with type 2 diabetes mellitus (T2DM) patients have vitamin D deficiency, studies regarding vitamin D supplementation on insulin resistance (IR) have mainly focused on non-Asians.	Vitamin D	141-150	insulin	Homo sapiens	170-177
34884121-4	2021	Body fat percentage obtained from the InBody device and blood parameters albumin and lactate dehydrogenase correlated with vitamin D level.	Vitamin D	123-132	albumin	Homo sapiens	73-80
34959910-0	2021	Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance.	Vitamin D	0-9	insulin	Homo sapiens	82-89
34959910-1	2021	The study was conducted to comprehensively assess the association of the concentration of vitamin D in the blood and insulin resistance in non-diabetic subjects.	Vitamin D	90-99	insulin	Homo sapiens	117-124
34959910-6	2021	Homeostatic Model Assessment of Insulin Resistance (HOMAIR) was used as the measure of insulin resistance and correlation coefficient was used as a measure of the relationship between vitamin D levels and the insulin resistance.	Vitamin D	184-193	insulin	Homo sapiens	87-94
34959910-6	2021	Homeostatic Model Assessment of Insulin Resistance (HOMAIR) was used as the measure of insulin resistance and correlation coefficient was used as a measure of the relationship between vitamin D levels and the insulin resistance.	Vitamin D	184-193	insulin	Homo sapiens	209-216
34959910-8	2021	The results showed an inverse association between the status of vitamin D and insulin resistance (r = -0.217; 95% CI = -0.161 to -0.272; p = 0.000).	Vitamin D	64-73	insulin	Homo sapiens	78-85
34959910-9	2021	A supplement of vitamin D can help reduce the risk of insulin resistance; however further studies, like randomized controlled trials are needed to confirm the results.	Vitamin D	16-25	insulin	Homo sapiens	54-61
34925313-3	2021	Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR).	Vitamin D	12-21	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
34725922-7	2021	Mechanistic investigation revealed that Abeta upregulated VDR without its canonical ligand vitamin D and switched its heterodimer binding-partner from RXR to p53.	Vitamin D	91-100	amyloid beta precursor protein	Homo sapiens	40-45
34166649-5	2021	Overweight and obese patients with HOMA-IR >2.5, positive for HER2 and with high Ki-67 index had the most severe vitamin D deficiency.	Vitamin D	113-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-66
34643152-0	2021	25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFbeta-mediated nuclear translocation mechanism of YAP/TAZ.	Vitamin D	7-16	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	129-132
34695445-9	2021	Individuals with vitamin D sufficiency (25-OH-D >50 nmol/L) exhibited a 5% lower level of PTH compared to the whole sample population (p<.001).	Vitamin D	17-26	parathyroid hormone	Homo sapiens	90-93
34857198-5	2021	Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications.	Vitamin D	18-27	interleukin 6	Homo sapiens	181-194
34857198-5	2021	Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications.	Vitamin D	18-27	interleukin 6	Homo sapiens	196-200
34857198-5	2021	Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications.	Vitamin D	18-27	interleukin 6	Homo sapiens	269-273
34857198-6	2021	Vitamin D also have its effect on angiotensin converting enzyme (ACEII) inhibitor through which the COVID-19 virus makes cell entry.	Vitamin D	0-9	angiotensin I converting enzyme	Homo sapiens	34-63
34857202-7	2021	RESULTS: There was a noticeable regular trend regarding hypercholesterolemia (p = 0.008), high LDL-C (p = 0.024), hypertension (p = 0.021), and high hs-CRP (p < 0.0001) across various categories of vitamin D status.	Vitamin D	198-207	C-reactive protein	Homo sapiens	152-155
34857202-8	2021	In adjusted model, vitamin D-deficient subjects were at higher risk for having hypercholesterolemia (OR: 3.22, p = 0.031), high LDL-C (OR: 2.37, p = 0.047), hypertension (OR: 2.32, p = 0.042), and high hs-CRP (OR: 5.49, p = 0.001) than ones with sufficient vitamin D status.	Vitamin D	19-28	C-reactive protein	Homo sapiens	205-208
34857202-9	2021	CONCLUSIONS: Vitamin D deficiency in obese subjects was found to be strongly related to higher risk of unfavorable lipid profile, hypertension, and high hs-CRP.	Vitamin D	13-22	C-reactive protein	Homo sapiens	156-159
34478973-8	2021	While, this effects of vitamin D were slashed in Atg7flox/flox Lyz2-cre mice.	Vitamin D	23-32	lysozyme 2	Mus musculus	63-67
34956363-1	2021	Objective: Given its role in the regulation of calcium and PTH levels, vitamin D was presumed as a potential predictor of postoperative hypoparathyroidism.	Vitamin D	71-80	parathyroid hormone	Homo sapiens	59-62
34956363-3	2021	This study aims to reveal the relationship between preoperative vitamin D and postoperative parathyroid hormone (PTH).	Vitamin D	64-73	parathyroid hormone	Homo sapiens	92-111
34956363-3	2021	This study aims to reveal the relationship between preoperative vitamin D and postoperative parathyroid hormone (PTH).	Vitamin D	64-73	parathyroid hormone	Homo sapiens	113-116
34956363-10	2021	By multivariate logistic regression analysis, vitamin D insufficiency was an independent predictor of postoperative PTH reduction ratio >= 50% (OR = 2.2, p=0.017).	Vitamin D	46-55	parathyroid hormone	Homo sapiens	116-119
34956363-12	2021	However, vitamin D insufficiency is an independent predictor of postoperative PTH reduction ratio.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	78-81
34853015-1	2021	OBJECTIVE: To compare and assess the efficacy of two vitamin D delivery systems (oil-based and microencapsulated) on 25-hydroxy-vitamin D (25(OH)D) levels, body mass index (BMI) and insulin resistance (IR) in women with established polycystic ovary syndrome (PCOS) and vitamin D deficiency.	Vitamin D	53-62	insulin	Homo sapiens	182-189
34435414-1	2021	BACKGROUND: Among multiple sclerosis (MS) patients, an association has been observed between low levels of vitamin D and high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels.	Vitamin D	107-116	EBNA-1	Human gammaherpesvirus 4	158-164
34460994-13	2021	OVA-sensitized asthma induced airway remodeling and elevated IgE content in mice, which was downregulated after vitamin D treatment.	Vitamin D	112-121	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-3
34460994-15	2021	Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level.	Vitamin D	153-162	interleukin 10	Mus musculus	82-87
34460994-15	2021	Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level.	Vitamin D	153-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	214-223
34460994-17	2021	In conclusion, vitamin D rectified the Th17/Treg balance and alleviated airway inflammation by inhibiting the NF-kappaB pathway in asthmatic mice.	Vitamin D	15-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
34873873-8	2021	By examining the excretion of radiolabeled vitamin D3 injected unbound or pre-bound by DBP, we attributed the increased activity of skin-generated vitamin D3 to a significant reduction in biliary excretion of DBP-bound vitamin D relative to unbound vitamin D.	Vitamin D	219-228	D-box binding PAR bZIP transcription factor	Homo sapiens	87-90
34873873-8	2021	By examining the excretion of radiolabeled vitamin D3 injected unbound or pre-bound by DBP, we attributed the increased activity of skin-generated vitamin D3 to a significant reduction in biliary excretion of DBP-bound vitamin D relative to unbound vitamin D.	Vitamin D	219-228	D-box binding PAR bZIP transcription factor	Homo sapiens	209-212
34565175-1	2021	BACKGROUND AND PURPOSE: Experimental studies showed vitamin D (Vit-D) could promote vascular regeneration and repair.	Vitamin D	52-61	vitrin	Homo sapiens	63-66
34918524-4	2021	In kidneys, PTH stimulates 1alpha-hydroxylase to synthesize active vitamin D.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	12-15
34849546-13	2022	CONCLUSIONS: Of characteristics most commonly associated with vitamin D metabolism, only baseline 25(OH)D <20 ng/mL modified the PTH response to vitamin D supplementation, providing support from a clinical trial to use this threshold to define insufficiency.	Vitamin D	145-154	parathyroid hormone	Homo sapiens	129-132
34839468-6	2021	In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = -0.616 and -0.596, respectively) p <0.001 for both.	Vitamin D	39-48	C-reactive protein	Homo sapiens	80-98
34840966-7	2021	Vitamin D showed a significant negative correlation with LDH, CRP, ESR, ferritin, and D-dimer, which was the most reliable predictor of COVID-19 severity in T1DM patients.	Vitamin D	0-9	C-reactive protein	Homo sapiens	62-65
34807347-1	2021	PURPOSE: The purpose of the study is to observe the effects of active vitamin D supplementation on insulin resistance and islet beta-cell function (HOMA-beta) in patients with non-diabetic chronic kidney disease (NDCKD).	Vitamin D	70-79	insulin	Homo sapiens	99-106
34807347-12	2021	CONCLUSIONS: Active vitamin D supplementation improved insulin resistance and HOMA-beta after 6 months in ND patients, but only improved HOMA-beta in the dialysis patients, with no significant effect on insulin resistance.	Vitamin D	20-29	insulin	Homo sapiens	55-62
34833489-13	2021	Real-time polymerase chain reaction results demonstrated that the mRNA expression levels of RUNX2, OCN, and COL1A1 were significantly increased when vitamin D was added to the culture.	Vitamin D	149-158	RUNX family transcription factor 2	Homo sapiens	92-97
34833489-13	2021	Real-time polymerase chain reaction results demonstrated that the mRNA expression levels of RUNX2, OCN, and COL1A1 were significantly increased when vitamin D was added to the culture.	Vitamin D	149-158	bone gamma-carboxyglutamate protein	Homo sapiens	99-102
34792092-13	2021	The addition of milk to the diet may potentially increase the likelihood of preventing bone loss by restoring bone homeostasis through the modulation of calcium-vitamin D-PTH axis, bone remodeling rate, and growth hormone/IGF-1 axis.	Vitamin D	161-170	parathyroid hormone	Homo sapiens	171-174
34869440-0	2021	Early Changes of VEGF Levels After Zoledronic Acid in Women With Postmenopausal Osteoporosis: A Potential Role of Vitamin D.	Vitamin D	114-123	vascular endothelial growth factor A	Homo sapiens	17-21
34869440-3	2021	Increasing evidences demonstrate that vitamin D influences VEGF levels.	Vitamin D	38-47	vascular endothelial growth factor A	Homo sapiens	59-63
34869440-4	2021	The aim of this study was to investigate the influence of Zol on VEGF levels and the possible role for vitamin D on the Zol mediated changes of VEGF concentration in women with postmenopausal osteoporosis.	Vitamin D	103-112	vascular endothelial growth factor A	Homo sapiens	144-148
34869440-10	2021	For the first time, we detected early modifications of circulating VEGF in postmenopausal women receiving Zol for osteoporosis, identifying a vitamin D-dependent modulation of these changes.	Vitamin D	142-151	vascular endothelial growth factor A	Homo sapiens	67-71
34868584-8	2021	At baseline, the high IFN-alpha producer group showed higher expression of genes associated with plasmacytoid dendritic cells, the innate immune response and vitamin D activation, but lower expression of oxidative stress pathways than the low IFN-alpha producer group.	Vitamin D	158-167	interferon alpha 1	Homo sapiens	22-31
34869917-5	2021	Beta-adrenergic blockers, which negatively regulate renin release from juxtaglomerular cells, and vitamin D, as a regulator of the RAAS and renin expression, are proposed therapeutics in the treatment of COVID-19.	Vitamin D	98-107	renin	Homo sapiens	140-145
34851599-3	2021	In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma).	Vitamin D	33-42	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	83-90
34791470-0	2021	The Pattern of Vitamin D Levels in Children 0-4 Years of Age in Yunnan Province.	Vitamin D	15-24	renin binding protein	Homo sapiens	57-60
34849546-13	2022	CONCLUSIONS: Of characteristics most commonly associated with vitamin D metabolism, only baseline 25(OH)D <20 ng/mL modified the PTH response to vitamin D supplementation, providing support from a clinical trial to use this threshold to define insufficiency.	Vitamin D	62-71	parathyroid hormone	Homo sapiens	129-132
34781136-9	2021	PRACTICAL APPLICATION: The findings of the present study indicated that a low-fat yogurt fortified with 1500 IU nano-encapsulated vitamin D for ten weeks, leads to a significant reduction in serum hs-CRP and PAB concentrations highlighted the anti-inflammatory/anti-oxidative effect of vitamin D.	Vitamin D	130-139	C-reactive protein	Homo sapiens	200-203
34781136-9	2021	PRACTICAL APPLICATION: The findings of the present study indicated that a low-fat yogurt fortified with 1500 IU nano-encapsulated vitamin D for ten weeks, leads to a significant reduction in serum hs-CRP and PAB concentrations highlighted the anti-inflammatory/anti-oxidative effect of vitamin D.	Vitamin D	286-295	C-reactive protein	Homo sapiens	200-203
34859852-2	2021	Vitamin D (Vit D) deficiency has been associated with a high risk of infection and mortality in cirrhotic patients.	Vitamin D	0-9	vitrin	Homo sapiens	11-14
34803346-2	2021	This study aimed to compare the serum vitamin D (Vit D) and zinc levels in patients infected with novel coronavirus and healthy volunteers (HVs).	Vitamin D	38-47	vitrin	Homo sapiens	49-52
34619249-0	2021	Vitamin D association with the renin angiotensin system in polycystic ovary syndrome.	Vitamin D	0-9	renin	Homo sapiens	31-36
34619249-1	2021	Vitamin D deficiency is a negative endocrine renin-angiotensin system (RAS) modulator and PCOS women are often vitamin D deficient, leading to RAS overactivation in PCOS.	Vitamin D	0-9	renin	Homo sapiens	45-50
34619249-5	2021	In PCOS women, plasma renin was increased in vitamin D deficient and insufficient groups compared with the vitamin D sufficient group (p < 0.005), but did not differ across non-PCOS control subgroups.	Vitamin D	45-54	renin	Homo sapiens	22-27
34619249-8	2021	These data show that RAS activation through increased plasma renin levels was seen in vitamin D insufficient and deficient PCOS subjects compared to non-PCOS control women.	Vitamin D	86-95	renin	Homo sapiens	61-66
34273568-14	2021	The three genes are associated with inflammation control and arthritis, and SSH2 and NLRP1are also related to vitamin D modulation.	Vitamin D	110-119	NLR family pyrin domain containing 1	Homo sapiens	85-90
34836111-8	2021	Vitamin D (Vit D) seems to be a promising agent due to its beneficial effect on placental implantation, the immune system, and angiogenic factors.	Vitamin D	0-9	vitrin	Homo sapiens	11-14
34737778-1	2021	Objective: To discuss the influence of high-dose recombinant human growth hormone (rhGH) therapy on serum vitamin D and insulin-like growth factor-1 (IGF-1) levels in school-age children with idiopathic short stature (ISS).	Vitamin D	106-115	growth hormone 1	Homo sapiens	67-81
34174792-8	2021	CRP,TNF-?, IL-6 and IL-10 levels were also correlated with serum vitamin D levels (p <0.05).	Vitamin D	65-74	C-reactive protein	Homo sapiens	0-9
34174792-8	2021	CRP,TNF-?, IL-6 and IL-10 levels were also correlated with serum vitamin D levels (p <0.05).	Vitamin D	65-74	interleukin 6	Homo sapiens	11-15
34948669-0	2021	Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	49-68
34836309-0	2021	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.	Vitamin D	20-29	interleukin 1 beta	Homo sapiens	142-146
34836309-0	2021	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.	Vitamin D	20-29	interferon gamma	Homo sapiens	148-152
34836309-0	2021	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.	Vitamin D	20-29	cathelicidin antimicrobial peptide	Homo sapiens	167-171
34836309-9	2021	The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1.	Vitamin D	84-93	interleukin 1 beta	Homo sapiens	148-152
34836309-9	2021	The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1.	Vitamin D	84-93	interferon gamma	Homo sapiens	154-158
34836309-9	2021	The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1.	Vitamin D	84-93	cathelicidin antimicrobial peptide	Homo sapiens	173-177
34758788-1	2021	BACKGROUND: Vitamin D (Vit D) deficiency/insufficiency is an important risk factor for several chronic conditions.	Vitamin D	12-21	vitrin	Homo sapiens	23-26
34749737-5	2021	In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway.	Vitamin D	66-75	interferon alpha 1	Homo sapiens	165-168
34749737-7	2021	In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement.	Vitamin D	48-57	interferon alpha 1	Homo sapiens	81-84
34803681-8	2021	Vitamin D reduced body weight (P = 0.007), body mass index (P = 0.002), waist circumstance (WC) (P = 0.02), serum alanine transaminase (ALT) (P = 0.01), fasting blood sugar (FBS) (P = 0.01), homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.004), and calcium (P = 0.01).	Vitamin D	0-9	insulin	Homo sapiens	224-231
34536747-0	2021	Role of vitamin D/VDR nuclear translocation in down-regulation of NF-kappaB/NLRP3/caspase-1 axis in lupus nephritis.	Vitamin D	8-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
34857984-6	2021	Vitamin D supplementation significantly improved fasting blood glucose, postprandial blood glucose, and quantitative insulin sensitivity check index in diabetes and prediabetes with baseline 25(OH)D<30 ng/ml.	Vitamin D	0-9	insulin	Homo sapiens	117-124
34857984-8	2021	The positive effects of vitamin D supplementation on body mass index, waist, HDL-C, LDL-C, and CRP were also demonstrated.	Vitamin D	24-33	C-reactive protein	Homo sapiens	95-98
34857984-9	2021	In conclusion, modest improvements in vitamin D supplementation on short-term glycose homeostasis, insulin sensitivity, and disease development in diabetes and prediabetes with 25(OH)D<30 ng/ml were demonstrated, but more research needs to be conducted in the future to support the clinical application.	Vitamin D	38-47	insulin	Homo sapiens	99-106
34463016-3	2021	In recent years while exploring the etiological factors responsible for the emergence of insulin resistance particularly that of transient nature, vitamin D has emerged as one of the possible factors.	Vitamin D	147-156	insulin	Homo sapiens	89-96
34453946-4	2021	Human ZMIZ1 is additionally characterized as a latitude-dependent autoimmune disease (LDAD) risk gene, as it is responsive to vitamin D and has been associated with at least eleven blood cell traits.	Vitamin D	126-135	zinc finger MIZ-type containing 1	Homo sapiens	6-11
34510707-0	2021	The complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine.	Vitamin D	34-43	ATP binding cassette subfamily G member 5	Homo sapiens	12-17
34829802-2	2021	Vitamin D binding protein (DBP) is coded by the GC gene, is involved in the transport of vitamin D, and includes a number of isoforms based on single nucleotide polymorphisms (SNPs) in the coding region at rs7041 and rs4855.	Vitamin D	89-98	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
34842603-5	2021	The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former.	Vitamin D	40-49	interleukin 6	Homo sapiens	121-125
34842603-5	2021	The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former.	Vitamin D	40-49	tumor necrosis factor	Homo sapiens	127-136
34842603-8	2021	Taken together, the results of this study suggest that modulating expression of IL-33, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs with vitamin D supplementation may serve as a novel therapeutic to attenuate inflammation and cartilage degeneration in osteoarthritis.	Vitamin D	131-140	interleukin 6	Homo sapiens	87-91
34842603-8	2021	Taken together, the results of this study suggest that modulating expression of IL-33, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs with vitamin D supplementation may serve as a novel therapeutic to attenuate inflammation and cartilage degeneration in osteoarthritis.	Vitamin D	131-140	tumor necrosis factor	Homo sapiens	93-102
34702787-8	2022	RESULTS: The corresponding adjusted odds ratios associated with vitamin D insufficiency (<50 nmol/L) were 1.09 (95% confidence interval, 0.87-1.37) for 1 to 499 MET minutes per week of TPA, 0.69 (0.52-0.91) for 500 to 1000 MET minutes per week of TPA, and 0.95 (0.72-1.26) for >1000 MET minutes per week of TPA, respectively, compared with no TPA.	Vitamin D	64-73	plasminogen activator, tissue type	Homo sapiens	185-188
34702787-11	2022	CONCLUSIONS: A moderate level of TPA is related to lower odds of suboptimal vitamin D status among women of childbearing age.	Vitamin D	76-85	plasminogen activator, tissue type	Homo sapiens	33-36
34549226-10	2021	Therefore, vitamin D could affect the epigenetic status of IL6, which can be considered for additional preventive strategies.	Vitamin D	11-20	interleukin 6	Homo sapiens	59-62
34722576-0	2021	Elevated NLRP3 Inflammasome Levels Correlate With Vitamin D in the Vitreous of Proliferative Diabetic Retinopathy.	Vitamin D	50-59	NLR family pyrin domain containing 3	Homo sapiens	9-14
34722576-9	2021	Meanwhile, vitreous and serum vitamin D concentrations were significantly negatively correlated with vitreous NLRP3 expression in PDR patients.	Vitamin D	30-39	NLR family pyrin domain containing 3	Homo sapiens	110-115
34722576-13	2021	Conclusions: Our results demonstrate a strong correlation between increased NLRP3 inflammasome pathway and decreased vitamin D concentrations in the vitreous of PDR patients, which may be linked to PDR pathogenesis.	Vitamin D	117-126	NLR family pyrin domain containing 3	Homo sapiens	76-81
34722576-14	2021	In addition, vitamin D supplementation may play a key role in preventing, treating, and improving PDR prognosis due to its inhibitory impact on NLRP3 inflammasome pathway and VEGF.	Vitamin D	13-22	NLR family pyrin domain containing 3	Homo sapiens	144-149
34722576-14	2021	In addition, vitamin D supplementation may play a key role in preventing, treating, and improving PDR prognosis due to its inhibitory impact on NLRP3 inflammasome pathway and VEGF.	Vitamin D	13-22	vascular endothelial growth factor A	Homo sapiens	175-179
34656640-1	2022	RATIONALE & OBJECTIVES: Hypervolemia and vitamin D (Vit D) deficiency occur frequently in patients receiving peritoneal dialysis and may contribute to left ventricular hypertrophy (LVH).	Vitamin D	41-50	vitrin	Homo sapiens	52-55
34647497-5	2021	The expression of miR-375 was positively associated with the consumption of selenium (beta = 1.52), vitamin C (beta = 0.17) and vitamin D (beta = 13.01), and inversely associated with the consumption of added sugar (beta = -0.49), phosphorus (beta= -0.27) and vitamin B12 (beta = -10.80).	Vitamin D	128-137	microRNA 375	Homo sapiens	18-25
34721296-0	2021	Overlapping Phenotypes Associated With CYP24A1, SLC34A1, and SLC34A3 Mutations: A Cohort Study of Patients With Hypersensitivity to Vitamin D.	Vitamin D	132-141	solute carrier family 34 member 3	Homo sapiens	61-68
34647284-4	2022	Other therapies are being explored, and among them, the use of recombinant human parathyroid hormone (PTH) has proved to decrease the requirements of calcium and active vitamin D to reach adequate therapeutic goals.	Vitamin D	169-178	parathyroid hormone	Homo sapiens	81-100
34647284-4	2022	Other therapies are being explored, and among them, the use of recombinant human parathyroid hormone (PTH) has proved to decrease the requirements of calcium and active vitamin D to reach adequate therapeutic goals.	Vitamin D	169-178	parathyroid hormone	Homo sapiens	102-105
34656640-13	2022	Vitamin D supplementation increased serum Vit D concentration but had no effect on left ventricular mass.	Vitamin D	0-9	vitrin	Homo sapiens	42-45
34791470-7	2021	CONCLUSION: Our study suggested that sex and age affected the vitamin D levels of children, and a reasonable reference range in children 0-4 years of age in Yunnan Province was determined.	Vitamin D	62-71	renin binding protein	Homo sapiens	45-48
34791470-7	2021	CONCLUSION: Our study suggested that sex and age affected the vitamin D levels of children, and a reasonable reference range in children 0-4 years of age in Yunnan Province was determined.	Vitamin D	62-71	renin binding protein	Homo sapiens	150-153
34749325-0	2021	BONE FORMATION MARKERS (N-TERMINAL PROPEPTIDE TYPE I PROCOLLAGEN, OSTEOCALCIN AND VITAMIN D) AS EARLY PREDICTORS OF OSTEOPOROSIS IN PATIENTS SUFFERING FROM CHRONIC OBSTRUCTIVE LUNG DISEASE.	Vitamin D	82-91	microtubule affinity regulating kinase 1	Homo sapiens	15-22
34076286-0	2021	Vitamin D status determines the impact of metformin on circulating prolactin levels in premenopausal women.	Vitamin D	0-9	prolactin	Homo sapiens	67-76
34076286-3	2021	The aim of the current study was to investigate whether vitamin D status determines the impact of metformin on prolactin levels in premenopausal women with hyperprolactinaemia.	Vitamin D	56-65	prolactin	Homo sapiens	111-120
34684492-0	2021	Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice.	Vitamin D	48-57	insulin	Homo sapiens	62-69
34684492-3	2021	In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest.	Vitamin D	42-51	insulin	Homo sapiens	56-63
34684492-5	2021	In fact, vitamin D deficiency may be one of the factors accelerating the development of insulin resistance.	Vitamin D	9-18	insulin	Homo sapiens	88-95
34650431-8	2021	Geniposide and vitamin D could significantly decrease the levels of TNF-alpha and IL-6 in serum and colon, and increase the level of IL-10 in the colon.	Vitamin D	15-24	tumor necrosis factor	Mus musculus	68-77
34650431-8	2021	Geniposide and vitamin D could significantly decrease the levels of TNF-alpha and IL-6 in serum and colon, and increase the level of IL-10 in the colon.	Vitamin D	15-24	interleukin 6	Mus musculus	82-86
34650431-8	2021	Geniposide and vitamin D could significantly decrease the levels of TNF-alpha and IL-6 in serum and colon, and increase the level of IL-10 in the colon.	Vitamin D	15-24	interleukin 10	Mus musculus	133-138
34556723-4	2021	Results showed that mean circulating concentrations of 25OHD at birth was 7.64 +- 3.21 ng/ml indicating vitamin D deficiency.	Vitamin D	104-113	25OHD	Bos taurus	55-60
34684321-1	2021	Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual.	Vitamin D	5-14	insulin like growth factor 1	Homo sapiens	49-54
34680413-7	2021	We demonstrated that a combination of butyrate and active vitamin D (1 alpha, 25-dihydroxyvitamin D3) synergically reduced the severity of Salmonella colitis in C57BL/6 mice and reduced cecal inflammatory mIL-6, mIL-8, mTNF-alpha, and mIL-1beta mRNA expression, but enhanced the antimicrobial peptide mhBD-3 mRNA, compared to a single treatment.	Vitamin D	58-67	interleukin 6	Mus musculus	205-210
34680413-7	2021	We demonstrated that a combination of butyrate and active vitamin D (1 alpha, 25-dihydroxyvitamin D3) synergically reduced the severity of Salmonella colitis in C57BL/6 mice and reduced cecal inflammatory mIL-6, mIL-8, mTNF-alpha, and mIL-1beta mRNA expression, but enhanced the antimicrobial peptide mhBD-3 mRNA, compared to a single treatment.	Vitamin D	58-67	tumor necrosis factor	Mus musculus	219-229
34604382-8	2021	In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality (r = -0.341, p = 0.002) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	222-241
34604382-8	2021	In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality (r = -0.341, p = 0.002) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	243-246
34604382-10	2021	PSQI scores in the normal range of PTH (r = -0.377, p = 0.006) and in >600 pg/ml of PTH (r = -0.675, p = 0.011) had a correlation with vitamin D levels.	Vitamin D	135-144	parathyroid hormone	Homo sapiens	35-38
34604382-10	2021	PSQI scores in the normal range of PTH (r = -0.377, p = 0.006) and in >600 pg/ml of PTH (r = -0.675, p = 0.011) had a correlation with vitamin D levels.	Vitamin D	135-144	parathyroid hormone	Homo sapiens	84-87
34621269-5	2021	Accordingly, DBP in physiological concentrations would be expected to block the effect of vitamin D on T cells and dendritic cells.	Vitamin D	90-99	D-box binding PAR bZIP transcription factor	Homo sapiens	13-16
34546511-2	2022	Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7alpha-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain.	Vitamin D	45-54	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	106-136
34546511-2	2022	Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7alpha-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain.	Vitamin D	45-54	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	138-144
34580590-10	2021	A blunted PTH response to vitamin D deficiency is mainly observed among women with lower BMI.	Vitamin D	26-35	parathyroid hormone	Homo sapiens	10-13
34684492-6	2021	Vitamin D deficiency is a common problem in the population and may be associated with the pathogenesis of diseases related to insulin resistance, such as obesity, diabetes, metabolic syndrome (MS) and polycystic ovary syndrome (PCOS).	Vitamin D	0-9	insulin	Homo sapiens	126-133
34684492-8	2021	The benefits of 25(OH)D supplementation/repletion on bone health are well known, and although there is a biological plausibility linking the status of vitamin D and insulin resistance supported by basic and clinical research findings, well-designed randomized clinical trials as well as basic research are necessary to know the molecular pathways involved in this association.	Vitamin D	151-160	insulin	Homo sapiens	165-172
34544219-7	2021	RESULTS: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL).	Vitamin D	65-74	pentraxin 3	Homo sapiens	9-14
34544219-10	2021	Subclinical inflammation (PTX-3 ?0.640) and high TOS levels were negatively associated with vitamin D levels.	Vitamin D	92-101	pentraxin 3	Homo sapiens	26-31
34580590-0	2021	Prevalence and Determinants of a Blunted Parathyroid Hormone Response in Young Saudi Women with Vitamin D Deficiency: A Cross-Sectional Study.	Vitamin D	96-105	parathyroid hormone	Homo sapiens	41-60
34580590-4	2021	This study determined the prevalence of a blunted PTH response to vitamin D deficiency among apparently healthy young Saudi women and assessed anthropometric and biochemical factors associated with this response by performing a secondary analysis of data obtained from a cross-sectional study conducted at the "Center of Excellence for Osteoporosis research."	Vitamin D	66-75	parathyroid hormone	Homo sapiens	50-53
34537762-0	2022	MicroRNA-22 Level in Patients with Multiple Sclerosis and Its Relationship with Vitamin D and Vitamin D Receptor Levels.	Vitamin D	80-89	microRNA 22	Homo sapiens	0-11
34603404-0	2021	Corrigendum: Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.	Vitamin D	37-46	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	81-88
34510873-9	2021	Logistic regression analysis showed that having PA and deficiency of Vitamin D were risk factors for PTH elevation (both P<0.05).	Vitamin D	69-78	parathyroid hormone	Homo sapiens	101-104
34510873-10	2021	The ROC curve showed that the best cut-off value of PTH for the diagnosis of PA in patients with vitamin D deficiency was 56.44 ng/L, with a sensitivity of 66.5% and a specificity of 83.0%, and that in patients with normal vitamin D was 48.81 ng/L, with a sensitivity of 70.5% and a specificity of 72.6%.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	52-55
34509882-9	2021	Most significantly, vitamin D fortified diet increased percent survival in KO animals and decreased the level of microglia marker IBA-1 and mTOR (mammalian target of rapamycin) downstream targets pS6 and pAKT.	Vitamin D	20-29	mechanistic target of rapamycin kinase	Homo sapiens	140-144
34509882-9	2021	Most significantly, vitamin D fortified diet increased percent survival in KO animals and decreased the level of microglia marker IBA-1 and mTOR (mammalian target of rapamycin) downstream targets pS6 and pAKT.	Vitamin D	20-29	mechanistic target of rapamycin kinase	Homo sapiens	146-175
34509882-11	2021	Overall, these findings suggest that a vitamin D enriched diet had a significant impact on the behavioral phenotype of NS-Pten KO mice, suggesting that dietary manipulations could be a potential therapeutic option for autistic-like behavior.	Vitamin D	39-48	phosphatase and tensin homolog	Mus musculus	122-126
34578991-11	2021	Our results suggest that vitamin D deficiency might predispose to maternal cardiovascular risk and perinatal infections especially in male-carrying pregnancies, probably due to lower placental CYP27B1 and cathelicidin expression.	Vitamin D	25-34	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	193-200
34744508-10	2021	Vitamin D level had negative correlations with ferritin (R=-0.316, p=0.044) and CRP (R=-0.530, p=0.000).	Vitamin D	0-9	C-reactive protein	Homo sapiens	80-83
34484626-1	2021	Backgroud: It has been widely reported that vitamin D (vit D) affects preoperative, postoperative, and long-term outcomes after total knee arthroplasty (TKA).	Vitamin D	44-53	vitrin	Homo sapiens	55-58
34282078-7	2021	Vitamin D receptors (VDRs) can be expressed by immune cells, and different immune cells (macrophages, monocytes, dendritic cells, T cells, and B cells) can convert Vit D into its active form 1,25-(OH)2 D. Oral vitamin D intake can be a readily way to restrict the viral infection through down regulation of ACE2 receptor and to attenuate the disease severity by decreasing the frequency of cytokine storm and pulmonary pro-inflammatory response.	Vitamin D	210-219	vitrin	Homo sapiens	164-167
34089834-0	2021	Can vitamin D be considered an adiponectin secretagogue?	Vitamin D	4-13	adiponectin, C1Q and collagen domain containing	Homo sapiens	31-42
34089834-2	2021	There is some evidence for ameliorating effect of vitamin D on glycemic and lipidemic status which are likely to be mediated through other molecules including adiponectin.	Vitamin D	50-59	adiponectin, C1Q and collagen domain containing	Homo sapiens	159-170
34089834-4	2021	This study was conducted to evaluate the effect of vitamin D supplementation on serum adiponectin concentration.	Vitamin D	51-60	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
34089834-11	2021	The results of this meta-analysis study indicates that vitamin D may be considered an adiponectin secretagogue in subjects with diabetes and this effect may be potentiated if vitamin D intake is on daily basis and in combination with calcium but can be weakened by increasing BMI.	Vitamin D	55-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
34089834-11	2021	The results of this meta-analysis study indicates that vitamin D may be considered an adiponectin secretagogue in subjects with diabetes and this effect may be potentiated if vitamin D intake is on daily basis and in combination with calcium but can be weakened by increasing BMI.	Vitamin D	175-184	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
34081342-0	2021	The immunoregulatory axis (Programmed death-1/ Programmed death ligand-1) on CD4+ T cells in lupus nephritis: association with vitamin D and chemokine C-X-C motif ligand 12.	Vitamin D	127-136	CD4 molecule	Homo sapiens	77-80
34464543-11	2021	COVID-19 patients with low vitamin D levels had a greater prevalence of hypertension and cardiovascular diseases, abnormally high serum troponin and peak D-dimer levels, as well as elevated interleukin-6 and C-reactive protein than those with serum 25(OH)D levels >=30 ng/ml.	Vitamin D	27-36	interleukin 6	Homo sapiens	190-203
34464543-11	2021	COVID-19 patients with low vitamin D levels had a greater prevalence of hypertension and cardiovascular diseases, abnormally high serum troponin and peak D-dimer levels, as well as elevated interleukin-6 and C-reactive protein than those with serum 25(OH)D levels >=30 ng/ml.	Vitamin D	27-36	C-reactive protein	Homo sapiens	208-226
34197883-6	2021	Thus, in addition to their classical antioxidative properties usually associated with mitochondrial effects, it is known that MEL and vitamin D modulate the expression and activity of Cu/Zn-dependent SOD isoforms, MTs and CP; function as copper chelators and regulate genomic and non-genomic mechanisms related to the zinc transport.	Vitamin D	134-143	superoxide dismutase 1	Homo sapiens	200-203
34576798-8	2021	The significant overall damages exerted by the immune-mediated responses under the hyper-expression of proinflammatory cytokines and interleukins, such as IL-6, may be facilitated by either a decreased level of vitamin D or the ageing process.	Vitamin D	211-220	interleukin 6	Homo sapiens	155-159
34273212-8	2021	BMI, total bilirubin, FFM, and GGT were found to have a positive relationship and homeostatic model assessment for insulin resistance, MCV, MCHC, fat percentage, total protein, and WHR were found to have a negative correlation to vitamin D concentration in response to supplementation.	Vitamin D	230-239	insulin	Homo sapiens	115-122
34475327-0	2021	Vitamin D and hydroxychloroquine reduce renal injury and Ki67 expression in a rat model of IgA nephropathy via TLR4.	Vitamin D	0-9	toll-like receptor 4	Rattus norvegicus	111-115
34646691-1	2021	Background Vitamin D (Vit-D) plays a central role in calcium homeostasis and maintains skeletal integrity.	Vitamin D	11-20	vitrin	Homo sapiens	22-25
34403036-7	2021	Further, plasmatic vitamin D negatively correlated with TGFbeta1, while positively correlated with AC haplotype.	Vitamin D	19-28	transforming growth factor beta 1	Homo sapiens	56-64
34459959-1	2022	Vitamin D is reported to have anti-inflammatory and insulin-sensitizing effects, yet vitamin D effects on hepatic fat content in children with nonalcoholic fatty liver disease (NAFLD) are not studied sufficiently.	Vitamin D	0-9	insulin	Homo sapiens	52-59
34459959-9	2022	There were significant decrease of AST, ALT, TG, LDL, FBG, FBI, and HOMA-IR and significant increase of vitamin D levels and HDL in the treatment group compared to the placebo group (P < 0.05).Conclusion: Vitamin D supplementation was found to be beneficial in the treatment of NAFLD in children.Trial registration: www.pactr.org , PACTR201710002634203.	Vitamin D	205-214	solute carrier family 17 member 5	Homo sapiens	35-38
34578857-0	2021	Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women.	Vitamin D	16-25	insulin	Homo sapiens	61-68
34578863-1	2021	Considering the role of bone metabolism in understanding the pathogenesis of osteoporosis, the aim of the present study was to examine the effects of vitamin D-enriched cheese on the serum concentrations of the parathyroid hormone (PTH) and certain bone remodeling biomarkers in postmenopausal women in Greece.	Vitamin D	150-159	parathyroid hormone	Homo sapiens	211-230
34578863-1	2021	Considering the role of bone metabolism in understanding the pathogenesis of osteoporosis, the aim of the present study was to examine the effects of vitamin D-enriched cheese on the serum concentrations of the parathyroid hormone (PTH) and certain bone remodeling biomarkers in postmenopausal women in Greece.	Vitamin D	150-159	parathyroid hormone	Homo sapiens	232-235
34578863-5	2021	In vitamin D-insufficient women that were less than 5 years at menopause, consumption of vitamin D-enriched cheese was also associated with lower serum PTH (Beta -0.63 +- 1.11; p < 0.001) and TRAP-5b (Beta -0.65 +- 0.23; p = 0.004) levels at follow-up, compared with the CG.	Vitamin D	89-98	parathyroid hormone	Homo sapiens	152-155
34578863-6	2021	The present study showed that daily intake of 5.7 mug of vitamin D through enriched cheese increased serum 25(OH)D concentrations, prevented PTH increase and reduced bone resorption in vitamin D-insufficient early postmenopausal women, thus reflecting a potential food-based solution for reducing the risk of bone loss occurring after menopause.	Vitamin D	57-66	parathyroid hormone	Homo sapiens	141-144
34589329-3	2021	Vitamin D (Vit D) regulates the absorption of calcium and phosphorus and thus, is universally accepted as an essential vitamin for bone strength as well as a facilitator of immune system function.	Vitamin D	0-9	vitrin	Homo sapiens	11-14
34466017-2	2021	We aimed to investigate the effects of dietary vitamin D deficiency or supplementation initiated in lactation and early life on inflammation and autophagy in an ovalbumin (OVA) mouse model.	Vitamin D	47-56	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	161-170
34466017-2	2021	We aimed to investigate the effects of dietary vitamin D deficiency or supplementation initiated in lactation and early life on inflammation and autophagy in an ovalbumin (OVA) mouse model.	Vitamin D	47-56	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	172-175
34466017-7	2021	Results: OVA sensitization and challenge induced dramatic allergic airway inflammation and higher RL in the vitamin D-deficient group compared with vitamin D-sufficient or the supplemented group.	Vitamin D	108-117	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	9-12
34466017-7	2021	Results: OVA sensitization and challenge induced dramatic allergic airway inflammation and higher RL in the vitamin D-deficient group compared with vitamin D-sufficient or the supplemented group.	Vitamin D	148-157	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	9-12
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	98-107	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	118-121
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	165-174	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	188-191
34466017-12	2021	Vitamin D may modulate autophagy in lungs of OVA sensitized/challenged mice, thus playing a protective role in OVA-induced allergic airway inflammation.	Vitamin D	0-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	45-48
34466017-12	2021	Vitamin D may modulate autophagy in lungs of OVA sensitized/challenged mice, thus playing a protective role in OVA-induced allergic airway inflammation.	Vitamin D	0-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	111-114
34489860-1	2021	Vitamin D deficiency could play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) as it may alter several crucial processes in the development of diabetes and its complications, such as pancreatic insulin secretion, peripheral insulin resistance, persistence of systemic "sterile" inflammation and immune activation.	Vitamin D	0-9	insulin	Homo sapiens	250-257
34406392-0	2021	Sex-Dependent Association of Vitamin D With Insulin Resistance in Humans.	Vitamin D	29-38	insulin	Homo sapiens	44-51
34406392-1	2021	BACKGROUND: Animal studies suggested that vitamin D might decrease insulin resistance.	Vitamin D	42-51	insulin	Homo sapiens	67-74
34406392-3	2021	However, sex-specific association of vitamin D with insulin resistance in humans remains unclear.	Vitamin D	37-46	insulin	Homo sapiens	52-59
34406392-11	2021	CONCLUSION: Vitamin D was inversely and independently associated with insulin resistance only in women with vitamin D deficiency.	Vitamin D	12-21	insulin	Homo sapiens	70-77
34406392-12	2021	Based on our data, we suggest that in particular vitamin D deficient women might benefit from vitamin D substitution by improving insulin resistance.	Vitamin D	49-58	insulin	Homo sapiens	130-137
34406392-12	2021	Based on our data, we suggest that in particular vitamin D deficient women might benefit from vitamin D substitution by improving insulin resistance.	Vitamin D	94-103	insulin	Homo sapiens	130-137
34445530-4	2021	The aim of this study was to evaluate the effect of vitamin D on the expression of IL-33, IL-37, macrophages, and caspase-1 in the neointimal tissue of coronary artery in Yucatan microswine with vitamin D deficient, sufficient, and supplemented status.	Vitamin D	52-61	caspase 1	Homo sapiens	114-123
34461991-1	2021	BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.	Vitamin D	91-100	tumor necrosis factor	Homo sapiens	134-143
34380489-1	2021	BACKGROUND: The relationship between vitamin D (VitD) and insulin sensitivity and secretion in type 2 diabetes mellitus (T2D) has been shown to be different amongst different ethnic populations.	Vitamin D	37-46	insulin	Homo sapiens	58-65
34461991-1	2021	BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.	Vitamin D	91-100	interleukin 6	Homo sapiens	145-149
34401915-7	2022	Vitamin D correlation with LL-37 in healthy contacts was R2=0.7 (95% CI 0.566 to 0.944), p<0.0001.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	27-32
34102194-0	2021	Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10alpha, TGF-beta and NRF-1 crosstalk.	Vitamin D	0-9	nuclear respiratory factor 1	Rattus norvegicus	140-145
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Vitamin D	14-23	SMAD family member 7	Rattus norvegicus	155-161
34458299-0	2021	The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-beta Dependent: A Proposed Anti-inflammatory Role in Airway Disease.	Vitamin D	40-49	serpin family A member 1	Homo sapiens	17-36
34458299-4	2021	Research Question: To understand the relationship between vitamin D, lung AAT levels and T lymphocytes further we investigated whether TGF-beta is required as a co-factor for 1,25(OH)2D3-induced upregulation of AAT by vitamin D in CD8+ T cells in vitro and correlated circulating vitamin D levels with lung AAT levels in vivo.	Vitamin D	218-227	serpin family A member 1	Homo sapiens	211-214
34165135-0	2021	Molecular mechanisms from insulin-mimetic effect of vitamin D: treatment alternative in Type 2 diabetes mellitus.	Vitamin D	52-61	insulin	Homo sapiens	26-33
34458299-13	2021	Conclusions: Vitamin D increases AAT expression in human T cells and this response is impaired in T cells from individuals homozygous for the Z allele of SERPINA1 in a clinic population.	Vitamin D	13-22	serpin family A member 1	Homo sapiens	33-36
34458299-13	2021	Conclusions: Vitamin D increases AAT expression in human T cells and this response is impaired in T cells from individuals homozygous for the Z allele of SERPINA1 in a clinic population.	Vitamin D	13-22	serpin family A member 1	Homo sapiens	154-162
34458299-14	2021	Furthermore, a correlation between circulating vitamin D and airway AAT is reported.	Vitamin D	47-56	serpin family A member 1	Homo sapiens	68-71
34458299-15	2021	We propose that vitamin D-induced AAT contributes to local immunomodulation and airway health effects previously attributed to vitamin D.	Vitamin D	16-25	serpin family A member 1	Homo sapiens	34-37
34458299-15	2021	We propose that vitamin D-induced AAT contributes to local immunomodulation and airway health effects previously attributed to vitamin D.	Vitamin D	127-136	serpin family A member 1	Homo sapiens	34-37
34375576-9	2021	C-reactive protein level was higher in the low vitamin D group, although the difference did not reach statistical significance (9.6 +- 2.2 vs. 4.5 +- 1.6 mg/l, P = 0.074).	Vitamin D	47-56	C-reactive protein	Homo sapiens	0-18
34444908-6	2021	Inositols and vitamin D supplementation, as well as micronutrients (zinc, chromium, magnesium) and pre/probiotics, result in modest improvement in insulin sensitivity, but their use is not systematically suggested.	Vitamin D	14-23	insulin	Homo sapiens	147-154
34165135-3	2021	Vitamin D deficiency appears to play an important role in the triggering mechanisms of insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	87-94
34165135-4	2021	In this review, an analysis is made of the biochemical mechanisms associated with the insulin-mimetic effect of vitamin D, its supplementation being a possible nutritional strategy for the T2DM treatment.	Vitamin D	112-121	insulin	Homo sapiens	86-93
34165135-5	2021	The current scientific evidence is extensive regarding the dose of vitamin D used for an insulin-mimetic effect.	Vitamin D	67-76	insulin	Homo sapiens	89-96
34338991-0	2021	Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons.	Vitamin D	106-115	protein disulfide isomerase family A, member 3	Rattus norvegicus	0-30
34362787-8	2021	Mean difference in eGFR from baseline was -1.0 ml/min per 1.73 m2 (95% CI, -1.3 to -0.7) in the vitamin D group and -0.1 ml/min per 1.73 m2 (95% CI, -0.4 to 0.2) in the placebo group; between-group difference was -1.0 ml/min per 1.73 m2 (95% CI, -1.4 to -0.6).	Vitamin D	96-105	epidermal growth factor receptor	Homo sapiens	19-23
34117551-9	2021	What is Known:   Vitamin D deficiency is more prevalent in obese children than nonobese controls, despite the same bone turnover markers and bone mineral density   The cutoff value of vitamin D level for the diagnosis of VDD is based on the PTH elevation What is New:   In obese adolescents, total and free vitamin D cutoff value for the diagnosis of VDD was lower than nonobese peers   Using the same cutoff value for vitamin D deficiency in both obese and nonobese adolescents may cause overtreatment.	Vitamin D	184-193	parathyroid hormone	Homo sapiens	241-244
34338991-1	2021	Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3).	Vitamin D	0-9	protein disulfide isomerase family A, member 3	Rattus norvegicus	128-158
34338991-1	2021	Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3).	Vitamin D	0-9	protein disulfide isomerase family A, member 3	Rattus norvegicus	160-165
34338991-3	2021	Yet, the potential basic pathways, of the biological interplay of DHCR24 and vitamin D equilibrium, on neuronal level, are yet to be determined.	Vitamin D	77-86	24-dehydrocholesterol reductase	Rattus norvegicus	66-72
34338991-4	2021	In this study, we aimed to investigate the relation between vitamin D pathways and DHCR24 in primary cortical neuron cultures.	Vitamin D	60-69	24-dehydrocholesterol reductase	Rattus norvegicus	83-89
34338991-12	2021	Results of this mechanistic experimental basic study demonstrate that DHCR24 mRNA expression and protein concentrations attenuated in response to vitamin D treatment.	Vitamin D	146-155	24-dehydrocholesterol reductase	Rattus norvegicus	70-76
34338991-14	2021	Our findings indicate a complex interaction of DHCR24 and vitamin D equilibrium, through the involvement of PDIA3 and vitamin D in the modulation of cholesterol metabolism in neuronal cells, requiring future studies on the field.	Vitamin D	58-67	24-dehydrocholesterol reductase	Rattus norvegicus	47-53
34272637-0	2021	Identification of kinase inhibitors that rule out the CYP27B1-mediated activation of vitamin D: an integrated machine learning and structure-based drug designing approach.	Vitamin D	85-94	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	54-61
34272637-1	2021	CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1alpha,25(OH)2D3).	Vitamin D	67-76	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
34272637-7	2021	This model was further employed for the virtual screening of kinase inhibitors from the binding database (DB), which tend to interfere with the CYP27B1-mediated activation of vitamin D.	Vitamin D	175-184	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	144-151
34272637-9	2021	Overall, five kinase inhibitors including two well-known drugs, i.e., AT7867 (Compound-2) and amitriptyline N-oxide (Compound-3), were found to interact with CYP27B1 in such a way that may preclude the conversion of vitamin D to its active form and hence testify the impairment of vitamin D activation pathway.	Vitamin D	216-225	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	158-165
34272637-9	2021	Overall, five kinase inhibitors including two well-known drugs, i.e., AT7867 (Compound-2) and amitriptyline N-oxide (Compound-3), were found to interact with CYP27B1 in such a way that may preclude the conversion of vitamin D to its active form and hence testify the impairment of vitamin D activation pathway.	Vitamin D	281-290	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	158-165
34246812-7	2021	Gene expression profiles for other known fibroblast immune mediators (SAA3 and CCL20) did not show significant differences between haplotypes but NOS2 gene expression was significantly elevated in response to vitamin D, even above the level detected in response to both TLR ligands.	Vitamin D	209-218	C-C motif chemokine ligand 20	Bos taurus	79-84
34733035-3	2021	It has been reported that there is an impaired response of parathyroid hormone (PTH) to vitamin D deficiency in critically ill children and adults.	Vitamin D	88-97	parathyroid hormone	Homo sapiens	59-78
34733035-3	2021	It has been reported that there is an impaired response of parathyroid hormone (PTH) to vitamin D deficiency in critically ill children and adults.	Vitamin D	88-97	parathyroid hormone	Homo sapiens	80-83
34733035-4	2021	Hence, we also sought to analyze the PTH response to vitamin D among the subgroup of critically ill children with sepsis.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	37-40
34126229-2	2021	Therefore, the present study was conducted on AGH patients to assess the impact of vitamin D on inflammatory cytokines such as CRP, TNF-alpha and IL-6.	Vitamin D	83-92	C-reactive protein	Homo sapiens	127-130
34126229-2	2021	Therefore, the present study was conducted on AGH patients to assess the impact of vitamin D on inflammatory cytokines such as CRP, TNF-alpha and IL-6.	Vitamin D	83-92	tumor necrosis factor	Homo sapiens	132-141
34126229-10	2021	Summarizing earlier studies, we demonstrated that circulating concentrations of inflammatory cytokines such as CRP, TNF-alpha, and IL-6 might be decreased following vitamin D supplementation among individuals with AGH.	Vitamin D	165-174	C-reactive protein	Homo sapiens	111-114
34126229-10	2021	Summarizing earlier studies, we demonstrated that circulating concentrations of inflammatory cytokines such as CRP, TNF-alpha, and IL-6 might be decreased following vitamin D supplementation among individuals with AGH.	Vitamin D	165-174	tumor necrosis factor	Homo sapiens	116-125
34126229-10	2021	Summarizing earlier studies, we demonstrated that circulating concentrations of inflammatory cytokines such as CRP, TNF-alpha, and IL-6 might be decreased following vitamin D supplementation among individuals with AGH.	Vitamin D	165-174	interleukin 6	Homo sapiens	131-135
34333809-8	2022	As Vitamin D is known to upregulate the expression of LL-37, the vitamin is a candidate preventive molecule.	Vitamin D	3-12	cathelicidin antimicrobial peptide	Homo sapiens	54-59
34389701-0	2021	The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes.	Vitamin D	30-39	adiponectin, C1Q and collagen domain containing	Homo sapiens	105-116
34389701-1	2021	BACKGROUND: Some evidence suggests indirect ameliorating effects of vitamin D in diabetes via adiponectin and sirtuins.	Vitamin D	68-77	adiponectin, C1Q and collagen domain containing	Homo sapiens	94-105
34389701-2	2021	This study aimed to evaluate the effects of daily intake of vitamin D-fortified yogurt drink, either with or without added calcium, on serum adiponectin, sirtuins (SIRT)1 and 6.	Vitamin D	60-69	adiponectin, C1Q and collagen domain containing	Homo sapiens	141-152
34323062-1	2021	OBJECTIVES: The association between serum Vitamin D (Vit.	Vitamin D	42-51	vitrin	Homo sapiens	53-56
34440979-1	2021	Background and Objectives: Vitamin D (Vit D) deficiency has been implicated in various conditions, including cardiovascular disease.	Vitamin D	27-36	vitrin	Homo sapiens	38-41
34325639-0	2022	Vitamin D affects the Warburg effect and stemness maintenance of non-small-cell lung cancer cells by regulating PI3K/AKT/mTOR signaling pathway.	Vitamin D	0-9	AKT serine/threonine kinase 1	Homo sapiens	117-120
34325639-0	2022	Vitamin D affects the Warburg effect and stemness maintenance of non-small-cell lung cancer cells by regulating PI3K/AKT/mTOR signaling pathway.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Homo sapiens	121-125
34442356-3	2021	Atopy, defined by high level of IgE for age, was associated with vitamin D deficient status (p = 0.041).	Vitamin D	65-74	immunoglobulin heavy constant epsilon	Homo sapiens	32-35
34214911-4	2021	While a close relationship has been established between vitamin D and IL-8 in other species, the role of genetic haplotype on temporal variation in vitamin D concentrations and its impact on immunity remains unexplored in cattle.	Vitamin D	56-65	C-X-C motif chemokine ligand 8	Bos taurus	70-74
34214911-7	2021	In contrast, circulating concentrations of 25(OH) vitamin D were negatively correlated (0.38) with IL-8, with elevated concentrations in calves of the IL8-h1 haplotype.	Vitamin D	50-59	C-X-C motif chemokine ligand 8	Bos taurus	99-103
34442356-6	2021	These results support a link between vitamin D and allergic and infectious inflammations, and specifically the association of vitamin D deficiency with asymptomatic atopy, defined as increased IgE level for age.	Vitamin D	126-135	immunoglobulin heavy constant epsilon	Homo sapiens	193-196
34377241-10	2021	AMA decreased NEFH (neurofilament protein) and MAP2 (microtubule binding protein) expression in offspring hippocampus, but vitamin D supplementation before pregnancy promoted NEFH and MAP2.	Vitamin D	123-132	microtubule-associated protein 2	Mus musculus	47-51
34292490-9	2022	We found that all subscales of KDQOL-36 were lower with statistically significance in the group with Vitamin D (Vit-D) deficiency.	Vitamin D	101-110	vitrin	Homo sapiens	112-115
34377241-10	2021	AMA decreased NEFH (neurofilament protein) and MAP2 (microtubule binding protein) expression in offspring hippocampus, but vitamin D supplementation before pregnancy promoted NEFH and MAP2.	Vitamin D	123-132	microtubule-associated protein 2	Mus musculus	184-188
34396023-1	2021	Objective: The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).	Vitamin D	66-75	vitrin	Homo sapiens	77-80
34396023-1	2021	Objective: The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).	Vitamin D	66-75	vitrin	Homo sapiens	114-117
34128826-1	2021	OBJECTIVE: GC/DBP effects on response to vitamin D supplementation have not been well-studied.	Vitamin D	41-50	D-box binding PAR bZIP transcription factor	Homo sapiens	14-17
34408941-2	2021	Defect in the activation of vitamin D in the kidneys due to chronic kidney disease (CKD) leads to hypocalcemia and hyperphosphatemia, resulting in a compensatory increase in parathyroid gland cellularity and parathyroid hormone production and causing secondary hyperparathyroidism (SHP).	Vitamin D	28-37	parathyroid hormone	Homo sapiens	208-227
34371843-7	2021	Vitamin D intake was related to the loss of muscle mass after adjusting for sex, age, exercise, alcohol, smoking, body mass index, SMI, glucagon-like peptide-1 agonist, sodium glucose cotransporter-2 inhibitor, insulin, HbA1c, creatinine, energy intake, and protein intake (adjusted odds ratio 0.93, 95% confidence interval: 0.88-0.97, p = 0.003).	Vitamin D	0-9	glucagon	Homo sapiens	136-159
34371843-7	2021	Vitamin D intake was related to the loss of muscle mass after adjusting for sex, age, exercise, alcohol, smoking, body mass index, SMI, glucagon-like peptide-1 agonist, sodium glucose cotransporter-2 inhibitor, insulin, HbA1c, creatinine, energy intake, and protein intake (adjusted odds ratio 0.93, 95% confidence interval: 0.88-0.97, p = 0.003).	Vitamin D	0-9	insulin	Homo sapiens	211-218
34357109-3	2021	Multivariable logistic regression models were used to analyze the association of CASR SNPs with circulating calcium, parathyroid hormone, vitamin D, and primary and secondary neoplasms.	Vitamin D	138-147	calcium sensing receptor	Homo sapiens	81-85
34453788-3	2021	The aim of the current study was to evaluate serum level of VEGF and its correlation with clinical features and vitamin D level in systemic sclerosis (SSc) Egyptian patients.	Vitamin D	112-121	vascular endothelial growth factor A	Homo sapiens	60-64
34281061-3	2021	In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Vitamin D	26-35	tumor necrosis factor	Homo sapiens	92-101
34281061-3	2021	In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Vitamin D	26-35	interleukin 6	Homo sapiens	113-117
34281061-3	2021	In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Vitamin D	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
34334004-1	2021	OBJECTIVE: Many studies have shown that vitamin D deficiency is associated with insulin resistance and metabolic syndrome.	Vitamin D	40-49	insulin	Homo sapiens	80-87
34584348-0	2021	Effect of Vitamin D on Urinary Angiotensinogen Level in Early Diabetic Nephropathy.	Vitamin D	10-19	angiotensinogen	Homo sapiens	31-46
34759510-2	2021	Introduction: Assessment of serum Vitamin D levels in healthy North Indian sportspersons and its correlation with serum parathyroid hormone (PTH) levels and bone mineral density (BMD).	Vitamin D	34-43	parathyroid hormone	Homo sapiens	120-139
34759510-2	2021	Introduction: Assessment of serum Vitamin D levels in healthy North Indian sportspersons and its correlation with serum parathyroid hormone (PTH) levels and bone mineral density (BMD).	Vitamin D	34-43	parathyroid hormone	Homo sapiens	141-144
34759510-5	2021	BMD and serum PTH levels were assessed in all athletes and correlation was seen with Vitamin D levels.	Vitamin D	85-94	parathyroid hormone	Homo sapiens	14-17
34759510-9	2021	Serum PTH levels were found to have inverse relations with both Vitamin D (r= -0.629) and BMD (r=-0.267).	Vitamin D	64-73	parathyroid hormone	Homo sapiens	6-9
34759510-10	2021	Conclusions: Vitamin D deficiency is highly prevalent among the North Indian athletes and the presence of low Vitamin D (<20 ng/ml) levels is associated with low BMD and high PTH levels.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	175-178
34759510-10	2021	Conclusions: Vitamin D deficiency is highly prevalent among the North Indian athletes and the presence of low Vitamin D (<20 ng/ml) levels is associated with low BMD and high PTH levels.	Vitamin D	110-119	parathyroid hormone	Homo sapiens	175-178
34416805-1	2021	The active form of vitamin D (Vit D), 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), is important for cell functions and immunity, as well as its role in bone metabolism.	Vitamin D	19-28	vitrin	Homo sapiens	30-33
34817518-2	2021	We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFalpha, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency.	Vitamin D	213-222	tumor necrosis factor	Homo sapiens	88-96
34634848-0	2021	(Correlation between insufficiency or deficiency of vitamin D levels and interleukins 1beta and 6).	Vitamin D	52-61	interleukin 1 beta	Homo sapiens	73-97
34209324-0	2021	Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation.	Vitamin D	0-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	75-84
34262557-11	2021	Vitamin D attenuated the seasonal increase in IFN-gamma by ~28% with mean ng/ml (SEM) for placebo vs vitamin D, respectively, for April 12.5(1.4) vs 10.0(1.2) (p=0.02); June 13.9(1.3) vs 10.2(1.7) (p=0.02) and January 7.4(1.1) vs 6.0(1.1) (p=0.04).	Vitamin D	0-9	interferon gamma	Homo sapiens	46-55
34262557-14	2021	Vitamin D attenuated the seasonal change in T cell-produced IFN-gamma, suggesting a decrease in effector response which could be associated with inflammation.	Vitamin D	0-9	interferon gamma	Homo sapiens	60-69
34733753-6	2021	Results: PBM at 1 and 2 J/cm2 combined with vitamin D significantly promoted HDPSCs proliferation through MTT assay and odontogenic differentiation through gene expression of VEGF, BMP-2, and DSPP levels (P < 0.0001).	Vitamin D	44-53	vascular endothelial growth factor A	Homo sapiens	175-179
34166428-3	2021	Vitamin D regulates immune responses through the vitamin D receptor on CD4 cells.	Vitamin D	0-9	CD4 molecule	Homo sapiens	71-74
34248925-3	2021	Objective: The aim was to investigate the association between NK cell activity (NKA) and multiple factors including vitamin D, physical exercise, age, and gender.	Vitamin D	116-125	tachykinin precursor 1	Homo sapiens	80-83
34248925-9	2021	Compared to men with low 25(OH)D serum level (< 20 ng/mL), vitamin D replete men (30-39.9 ng/mL) had significantly lower risk of very low NKA (OR: 0.358; 95% CI: 0.138, 0.929; P = 0.035).	Vitamin D	59-68	tachykinin precursor 1	Homo sapiens	138-141
34248925-13	2021	Conclusion: Physical exercise and vitamin D were associated with NKA in a gender- and age-dependent manner.	Vitamin D	34-43	tachykinin precursor 1	Homo sapiens	65-68
34239695-9	2021	The patients from the vitamin D sufficient cluster also had a significantly higher level of vitamin D/MPO, vitamin D/XO, vitamin D/MDA, vitamin D/CAT, and vitamin D/TRC than that in the vitamin deficient and insufficient clusters.	Vitamin D	22-31	myeloperoxidase	Homo sapiens	102-105
34239695-9	2021	The patients from the vitamin D sufficient cluster also had a significantly higher level of vitamin D/MPO, vitamin D/XO, vitamin D/MDA, vitamin D/CAT, and vitamin D/TRC than that in the vitamin deficient and insufficient clusters.	Vitamin D	22-31	catalase	Homo sapiens	146-149
34225429-10	2021	Results: Long-term vitamin D deficiency had increased acute liver failure sensitivity in mice, which was manifested by increased blood cell extravasation, massive necrosis of parenchymal cells, up-regulation of TNF-alpha, IL-1beta, and NLRP-3 mRNA expression (P < 0.05), and increased macrophages quantitation (P < 0.05) in liver tissues.	Vitamin D	19-28	tumor necrosis factor	Mus musculus	211-220
34208589-6	2021	Vitamin D via alleviation of insulin resistance, hyperglycemia, oxidative stress and inflammation reduces diabetes driven cancer risk factors.	Vitamin D	0-9	insulin	Homo sapiens	29-36
34208589-8	2021	It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation.	Vitamin D	84-93	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	160-167
34194851-2	2021	Causes of hypocalcemia with PTH elevation include increased phosphate load, vitamin D deficiency (VDD) or defects in metabolism, renal dysfunction, hypomagnesemia, genetic mutations resulting in end-organ resistance to PTH, or critical illness.	Vitamin D	76-85	parathyroid hormone	Homo sapiens	28-31
34103463-7	2021	RESULTS Our results indicated that vitamin D promoted A549 cell survival following LPS-induced inflammation by downregulating nuclear factor nuclear factor kappa light chain enhancer of activated B cells, tumor necrosis factor-alpha, interleukin (IL)-1ss, IL-6, and IL-12.	Vitamin D	35-44	tumor necrosis factor	Homo sapiens	205-232
34103463-7	2021	RESULTS Our results indicated that vitamin D promoted A549 cell survival following LPS-induced inflammation by downregulating nuclear factor nuclear factor kappa light chain enhancer of activated B cells, tumor necrosis factor-alpha, interleukin (IL)-1ss, IL-6, and IL-12.	Vitamin D	35-44	interleukin 6	Homo sapiens	256-260
34589658-1	2021	Circulating plasma vitamin D metabolites are highly bound to vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin.	Vitamin D	19-28	D-box binding PAR bZIP transcription factor	Homo sapiens	88-91
34094015-9	2021	A higher serum level of vitamin D was significantly associated with older age (p < 0.001).	Vitamin D	24-33	renin binding protein	Homo sapiens	74-77
34107623-7	2021	Gene expression of the regulatory enzyme of vitamin D metabolism, 1-alfa-hydroxylase (CYP27B1), was evaluated by two-step real-time qPCR.	Vitamin D	44-53	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	86-93
34484304-0	2021	Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.	Vitamin D	24-33	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	68-75
34484304-2	2021	Objective: This study aims to investigate whether 11 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (CYP2R1, CYP24A1, and CYP27B1) are associated with the risk of NAFLD.	Vitamin D	105-114	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	163-170
34347528-8	2021	Lower vitamin D levels were significantly associated with more severe COVID-19 cases (p-value < 0.001), higher blood levels of inflammatory markers including (D-dimer, CRP, and ferritin), a higher CT SS and longer disease duration.	Vitamin D	6-15	C-reactive protein	Homo sapiens	168-171
34183042-1	2021	BACKGROUND: To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-alpha (TNF-alpha) treatment.	Vitamin D	38-47	tumor necrosis factor	Homo sapiens	100-127
34183042-1	2021	BACKGROUND: To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-alpha (TNF-alpha) treatment.	Vitamin D	38-47	tumor necrosis factor	Homo sapiens	129-138
34183042-14	2021	Vitamin D reduced the phospho-NF-kappaB/p65 expression in the TNF-alpha-treated NP cells.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	30-40
34183042-14	2021	Vitamin D reduced the phospho-NF-kappaB/p65 expression in the TNF-alpha-treated NP cells.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	62-71
34183042-15	2021	CONCLUSION: Vitamin D can attenuate TNF-alpha-induced NP cells apoptosis through interfering with the NF-kappaB pathway.	Vitamin D	12-21	tumor necrosis factor	Homo sapiens	36-45
34183042-15	2021	CONCLUSION: Vitamin D can attenuate TNF-alpha-induced NP cells apoptosis through interfering with the NF-kappaB pathway.	Vitamin D	12-21	nuclear factor kappa B subunit 1	Homo sapiens	102-111
34107534-0	2021	Vitamin D concentration and its association with parathyroid hormone in children and adolescents.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	49-68
34107534-1	2021	BACKGROUND: Vitamin D (VD) deficiency has been inversely associated with parathyroid hormone (PTH) levels in the adult population but not in children and adolescents.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	73-92
34107534-1	2021	BACKGROUND: Vitamin D (VD) deficiency has been inversely associated with parathyroid hormone (PTH) levels in the adult population but not in children and adolescents.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	94-97
34113140-1	2021	Introduction: Clarifying the prevalence of vitamin D deficiency in diabetic patients, and the relationship between vitamin D concentration and insulin resistance, fasting plasma glucose, and HbA1C in patients in Hue City, Vietnam.	Vitamin D	115-124	insulin	Homo sapiens	143-150
34447494-2	2021	This study was designed to evaluate the independent or combined effect of calcium and vitamin D (Ca + Vit D) supplementation on blood lipid profile in overweight or obese premenopausal women.	Vitamin D	86-95	vitrin	Homo sapiens	102-105
34122339-1	2021	The aim of the present study, is to investigate the influence of obesity, with and without polycystic ovarian syndrome (PCOS), on the levels of kisspeptin, vitamin D (Vit D), and vascular endothelial growth factor (VEGF) and to explore the relationship between these parameters and endocrine and metabolic variables.	Vitamin D	156-165	vitrin	Homo sapiens	167-170
34079693-5	2021	METHODS: Linear regression explored the correlation between published representative-standardized population vitamin D concentrations and the number of total cases/million (M), recovered/M, deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated > 4 M (Worldometer).	Vitamin D	109-118	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	173-174
34079693-5	2021	METHODS: Linear regression explored the correlation between published representative-standardized population vitamin D concentrations and the number of total cases/million (M), recovered/M, deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated > 4 M (Worldometer).	Vitamin D	109-118	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	187-188
34079693-5	2021	METHODS: Linear regression explored the correlation between published representative-standardized population vitamin D concentrations and the number of total cases/million (M), recovered/M, deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated > 4 M (Worldometer).	Vitamin D	109-118	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	226-227
34079693-5	2021	METHODS: Linear regression explored the correlation between published representative-standardized population vitamin D concentrations and the number of total cases/million (M), recovered/M, deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated > 4 M (Worldometer).	Vitamin D	109-118	membrane glycoprotein	Severe acute respiratory syndrome coronavirus 2	282-283
34063822-0	2021	Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations.	Vitamin D	62-71	insulin	Homo sapiens	0-7
34063822-1	2021	Vitamin D has been implicated in the regulation of glucose metabolism and insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	74-81
34063822-2	2021	We designed this study to provide evidence that insulin resistance is dependent on the concentration of vitamin D in the body.	Vitamin D	104-113	insulin	Homo sapiens	48-55
34063822-8	2021	The observational studies included in this systematic review and meta-analysis showed an inverse relationship of insulin resistance with the status of vitamin D both in non-diabetic (r = -0.188; 95% CI = -0.141 to -0.234; p = 0.000) and diabetic (r = -0.255; 95% CI = -0.392 to -0.107, p = 0.001) populations.	Vitamin D	151-160	insulin	Homo sapiens	113-120
34065735-5	2021	Vitamin D enhances the innate immunity required for combating COVID-19 by activating toll-like receptor 2.	Vitamin D	0-9	toll like receptor 2	Homo sapiens	85-105
34065735-7	2021	Regarding adaptive immunity, vitamin D enhances CD4+ T cells, suppresses T helper 17 cells, and promotes the production of virus-specific antibodies by activating T cell-dependent B cells.	Vitamin D	29-38	CD4 molecule	Homo sapiens	48-51
34065735-8	2021	Moreover, vitamin D attenuates the release of pro-inflammatory cytokines by CD4+ T cells through nuclear factor kappaB signaling, thereby inhibiting the development of a cytokine storm.	Vitamin D	10-19	CD4 molecule	Homo sapiens	76-79
34065735-12	2021	Vitamin D inhibits renin expression and serves as a negative RAS regulator.	Vitamin D	0-9	renin	Homo sapiens	19-24
34063310-0	2021	Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	0-19
34107720-7	2021	Repeated measures variance was used to analyze the effects of vitamin D and omega-3 fatty acids on insulin metabolism markers and blood lipid profiles.	Vitamin D	62-71	insulin	Homo sapiens	99-106
34107720-11	2021	CONCLUSIONS: Combined supplementation with vitamin D and omega-3 fatty acids for 6 weeks in patients with GDM can effectively reduce blood sugar and blood lipids, improve HOMA-beta and insulin resistance, and ultimately effectively improve the glucose and lipid metabolism of patients.	Vitamin D	43-52	insulin	Homo sapiens	185-192
34095008-4	2021	Moreover, vitamin D controls energy metabolism in adipose tissue by affecting fatty acid oxidation, expression of uncoupling proteins, insulin resistance, and adipokine production.	Vitamin D	10-19	insulin	Homo sapiens	135-142
34408615-3	2021	This study aims to evaluate the effect of vitamin D on beta-catenin and cytokeratin 20 (KRT20) as markers of Wnt pathway activation for colonic cell repair.	Vitamin D	42-51	keratin 20	Mus musculus	72-86
34408615-3	2021	This study aims to evaluate the effect of vitamin D on beta-catenin and cytokeratin 20 (KRT20) as markers of Wnt pathway activation for colonic cell repair.	Vitamin D	42-51	keratin 20	Mus musculus	88-93
34408615-7	2021	Results: beta-catenin and KRT20 showed a significant increase in the proliferation index of vitamin D at a dose of 0.6 mug/25.0 g (91.50 +- 4.09 and 48.75 +- 2.28, respectively; p < 0.05) compared to the colitis group.	Vitamin D	92-101	keratin 20	Mus musculus	26-31
34267439-6	2021	A significant inverse correlation was found between vitamin D level and 24 h protein in urine, ANA, anti-dsDNA, CRP, with a significant positive correlation with renal biopsy indices, eGFR.	Vitamin D	52-61	C-reactive protein	Homo sapiens	112-115
34603696-1	2021	Background: Secondary hyperparathyroidism (SHPT) is a common and major complication in chronic kidney disease (CKD), reflecting the increase of parathyroid hormone (PTH) in response to reduced vitamin D signalling and hypocalcaemia.	Vitamin D	193-202	parathyroid hormone	Homo sapiens	144-163
34719640-7	2021	We also summarize endogenous and exogenous substrates metabolized by CYP3A isoforms, such as cholesterol, bile acids, hormones, arachidonic acid, vitamin D, and drugs.	Vitamin D	146-155	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-74
34347981-8	2021	Thus our primary objective is to research the therapeutic efficacy of vitamin D in the suppression of miR222 and, secondary to miR222, mediated molecular pathways involving insulin resistance and metabolic defects, which influence ovarian activity, anovula-tion, and finally infertility.	Vitamin D	70-79	insulin	Homo sapiens	173-180
34937505-12	2021	CONCLUSION: Vitamin D deficiency plays a significant role in the pathogenesis of GE and Vit D may be applied as its targeted therapy.	Vitamin D	12-21	vitrin	Homo sapiens	88-91
34139696-8	2021	In CSU patients, serum HBD2 level was negatively correlated with the peripheral basophil percentages (Spearman"s rho = -0.229, p = 0.01) and vitamin D levels (-0.262, p = 0.02), but positively correlated with TCTP levels (0.252, p = 0.006).	Vitamin D	141-150	defensin beta 4A	Homo sapiens	23-27
34817518-6	2021	RESULTS: In this study, there was a significant difference in CTRP-9, TNFalpha, total thiol (TT), native thiol (NT), DIS (disulfide), TT/DIS, and NT/DIS levels in vitamin D groups (p<0.05).	Vitamin D	163-172	tumor necrosis factor	Homo sapiens	70-78
34817518-8	2021	CONCLUSIONS: It was determined that vitamin D deficiency causes a significant decrease in CTRP-9 level and a significant increase in TNFalpha level, as well as an increase in thiol/disulfide hemostasis in favor of disulfide, which may be a risk factor for increased oxidative stress.	Vitamin D	36-45	tumor necrosis factor	Homo sapiens	133-141
34193674-0	2021	Association of Vitamin D Deficiency with Low Serum Albumin in Taiwanese Older Adults with Hip Fracture: A Prospective Cross-Sectional Study.	Vitamin D	15-24	albumin	Homo sapiens	51-58
34420582-7	2021	In addition, an antimicrobial peptide, LL-37, which is known to be partly regulated by vitamin D, was also reported to exhibit an anti-HCV effect by disrupting infectious viral particles directly.	Vitamin D	87-96	cathelicidin antimicrobial peptide	Homo sapiens	39-44
34387450-1	2021	OBJECTIVE: To evaluate the association polymorphisms in genes coding for enzymes involved in vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) with the risk of multiple sclerosis (MS).	Vitamin D	93-102	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	114-121
35490953-5	2022	Significant differences existed in the increase of CD4+ and CD8+ T cells based on vitamin D levels.	Vitamin D	82-91	CD4 molecule	Homo sapiens	51-54
35490953-6	2022	Vitamin D sufficiency group had a significantly higher increase of CD4+ T cells during 6 months of anti-TB treatment and CD8+ T cells after 4 months of anti-TB treatment than the other groups.	Vitamin D	0-9	CD4 molecule	Homo sapiens	67-70
35490953-8	2022	Conclusions Through null effects on sputum smear conversion, vitamin D may have a beneficial effect on the increase of CD4+ and CD8+ T cells during anti-TB treatment.	Vitamin D	61-70	CD4 molecule	Homo sapiens	119-122
35364123-0	2022	The link between vitamin D status and NF-kappaB-associated renal dysfunction in experimental diabetes mellitus.	Vitamin D	17-26	nuclear factor kappa B subunit 1	Homo sapiens	38-47
35364123-11	2022	Restoration of vitamin D status normalized vitamin D-endocrine system, decreased NF-kappaB activation and caspase-3 protein level in the kidneys of diabetic animals.	Vitamin D	15-24	nuclear factor kappa B subunit 1	Homo sapiens	81-90
35364123-11	2022	Restoration of vitamin D status normalized vitamin D-endocrine system, decreased NF-kappaB activation and caspase-3 protein level in the kidneys of diabetic animals.	Vitamin D	15-24	caspase 3	Homo sapiens	106-115
35369930-1	2022	The effects of vitamin D (Vit-D) deficiency and Vit-D treatment (VDT) on atrial fibrillation (AF) remain inconclusive.	Vitamin D	15-24	vitrin	Homo sapiens	26-29
35297524-13	2022	A high alkaline phosphatase (ALP) predicted lower vitamin D levels.	Vitamin D	50-59	alkaline phosphatase, placental	Homo sapiens	29-32
35380747-3	2022	However, there is growing evidence for a vitamin D-mediated increase of drug metabolism by induction of cytochrome P450 (CYP) 3A4.	Vitamin D	41-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-129
35380747-7	2022	RESULTS: We observed a negative relationship between vitamin D and dose-adjusted antipsychotic drug concentrations, which was particularly pronounced for drugs which are predominantly metabolized via CYP3A4 (i.e., aripiprazole and quetiapine).	Vitamin D	53-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	200-206
35380747-10	2022	CONCLUSION: Despite vitamin D"s potential benefits on physical and mental health, clinicians should be aware of its negative impact on blood concentrations of antipsychotics metabolized by CYP3A4 in patients with schizophrenia.	Vitamin D	20-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	189-195
35351538-0	2022	Vitamin D status and its association with parathyroid hormone in 23,134 outpatients.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	42-61
35620310-4	2022	Moreover, vitamin D has been associated with insulin resistance and DM.	Vitamin D	10-19	insulin	Homo sapiens	45-52
35241369-1	2022	PURPOSE: The primary objective of this study was to investigate the potential protective effect of Vitamin D (Vit D) on DOX induced cardio toxicity (DIC) in early breast cancer patients receiving adjuvant DOX based chemotherapy (AC).	Vitamin D	99-108	vitrin	Homo sapiens	110-113
35094425-11	2022	CONCLUSIONS: People with type 2 diabetes on insulin have high risk of macular oedema and DR. Vitamin D deficiency yielded almost 3 times greater odds of DR, while intensive blood pressure control reduces DR risk by 20% and moderate physical activity by 31%.	Vitamin D	93-102	insulin	Homo sapiens	44-51
35131190-3	2022	We hypothesized that transforming growth factor-beta1 (TGF-beta1) is increased in patients with DD in consequence of vitamin D deficiency, thereby leading to myofibroblast differentiation and subsequent progression of contractures.	Vitamin D	117-126	transforming growth factor beta 1	Homo sapiens	21-53
35131190-3	2022	We hypothesized that transforming growth factor-beta1 (TGF-beta1) is increased in patients with DD in consequence of vitamin D deficiency, thereby leading to myofibroblast differentiation and subsequent progression of contractures.	Vitamin D	117-126	transforming growth factor beta 1	Homo sapiens	55-64
35131190-15	2022	The potential role of vitamin D and its interaction with VDR and the TGF-beta1 signaling pathway in the pathogenesis of DD needs to be explored further.	Vitamin D	22-31	transforming growth factor beta 1	Homo sapiens	69-78
35351538-3	2022	Moreover, age and sex as well as confounding factors like calcium and phosphate may likewise affect the relationship between vitamin D and PTH in humans.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	139-142
35512569-0	2022	Vitamin D-induced LL-37 modulates innate immune responses of human primary macrophages during DENV-2 infection.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	18-23
35607635-1	2022	Purpose: Neuropsychiatric manifestation of lupus (NPSLE) is related with vitamin D (vit-D) deficiency which is possibly amenable to supplementation.	Vitamin D	73-82	vitrin	Homo sapiens	84-87
35512569-7	2022	Finally, we demonstrate that low endogenous levels and limited production of LL-37 in MDMs in response to DENV-2 infection can be increased by differentiating MDMs in the presence of Vitamin D (VitD3).	Vitamin D	183-192	cathelicidin antimicrobial peptide	Homo sapiens	77-82
35631274-0	2022	Plasma Myostatin Increases with Age in Male Youth and Negatively Correlates with Vitamin D in Severe Pediatric Obesity.	Vitamin D	81-90	myostatin	Homo sapiens	7-16
35631274-3	2022	This explorative study aims to investigate whether myostatin and irisin are associated with metabolic parameters, including the vitamin D status in pediatric patients with severe obesity.	Vitamin D	128-137	myostatin	Homo sapiens	51-60
35631274-9	2022	Strikingly, a negative correlation of myostatin with serum vitamin D levels was observed that remained significant after adjusting for age and pubertal stage.	Vitamin D	59-68	myostatin	Homo sapiens	38-47
35631274-10	2022	In conclusion, there is an independent association of low vitamin D and elevated myostatin levels.	Vitamin D	58-67	myostatin	Homo sapiens	81-90
35631265-6	2022	Recent advances in different pharmacological strategies are highlighted, with the potential to modulate the expression of ALP directly and indirectly in CKD-mineral and bone disorder (CKD-MBD), e.g., epigenetic modulation, phosphate binders, calcimimetics, vitamin D, and other anti-fracture treatments.	Vitamin D	257-266	alkaline phosphatase, placental	Homo sapiens	122-125
35579027-1	2022	BACKGROUND: Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels.	Vitamin D	16-25	C-reactive protein	Homo sapiens	115-133
35579027-1	2022	BACKGROUND: Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels.	Vitamin D	16-25	C-reactive protein	Homo sapiens	135-138
35580362-1	2022	PURPOSE: The aim of this study was to investigate tear function-associated clinical findings and conjunctival histopathological changes in children with vitamin D (Vit-D) deficiency.	Vitamin D	153-162	vitrin	Homo sapiens	164-167
35579027-2	2022	We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.	Vitamin D	71-80	C-reactive protein	Homo sapiens	92-95
35579027-8	2022	CONCLUSION: The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency.	Vitamin D	87-96	C-reactive protein	Homo sapiens	57-60
35626902-2	2022	There is some controversy concerning a potential interaction between vitamin D and PTH and the GH/IGF-1 axis.	Vitamin D	69-78	insulin like growth factor 1	Homo sapiens	98-103
35634307-6	2022	The bioactive form of vitamin D and a number of other compounds induce LL-37 expression and one might predict its upregulation, could reduce the prevalence of severe COVID-19.	Vitamin D	22-31	cathelicidin antimicrobial peptide	Homo sapiens	71-76
35569070-2	2022	Rifampin is an antituberculosis drug that is a potent inducer of cytochrome P450 3 subfamily A member 4 (CYP3A4), involved in an alternative catabolic pathway of vitamin D.	Vitamin D	162-171	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-103
35569070-2	2022	Rifampin is an antituberculosis drug that is a potent inducer of cytochrome P450 3 subfamily A member 4 (CYP3A4), involved in an alternative catabolic pathway of vitamin D.	Vitamin D	162-171	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111
35535979-10	2022	In participants with high-carbohydrate/low-fat diets and low vitamin D intakes, those with High-PRS had a higher risk of serum CRP concentrations than those with Low-PRS.	Vitamin D	61-70	C-reactive protein	Homo sapiens	127-130
35546181-0	2022	Additional treatment of vitamin D for improvement of insulin resistance in non-alcoholic fatty liver disease patients: a systematic review and meta-analysis.	Vitamin D	24-33	insulin	Homo sapiens	53-60
35546181-2	2022	Several studies already evaluate vitamin D supplementation for NAFLD patients in relation to insulin resistance.	Vitamin D	33-42	insulin	Homo sapiens	93-100
35546181-4	2022	This study aimed to evaluate the effect of additional treatment of vitamin D for the improvement of insulin resistance in NAFLD patients.	Vitamin D	67-76	insulin	Homo sapiens	100-107
35546181-8	2022	Vitamin D supplementation improves insulin resistance in NAFLD patients, marked by reduced Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), with pooled mean difference - 1.06 (p = 0.0006; 95% CI - 1.66 to - 0.45).	Vitamin D	0-9	insulin	Homo sapiens	35-42
35546181-8	2022	Vitamin D supplementation improves insulin resistance in NAFLD patients, marked by reduced Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), with pooled mean difference - 1.06 (p = 0.0006; 95% CI - 1.66 to - 0.45).	Vitamin D	0-9	insulin	Homo sapiens	124-131
35546181-12	2022	Vitamin D supplementation provides beneficial effects on the improvement of insulin resistance in NAFLD patients.	Vitamin D	0-9	insulin	Homo sapiens	76-83
35631138-1	2022	The aim of the study was to evaluate the vitamin D status in hospitalized COVID-19 patients and the correlation with C reactive protein (CRP), ferritin, fibrinogen, and peripheral blood leukocytes, as well as inflammatory derived indices.	Vitamin D	41-50	C-reactive protein	Homo sapiens	137-140
35138562-10	2022	CONCLUSION: Patients with active acromegaly have dysregulated vitamin D metabolism characterized by higher 1,25(ON)2D3, lower 24,25(ON)2D3 and altered DBP production.	Vitamin D	62-71	D-box binding PAR bZIP transcription factor	Homo sapiens	151-154
35625833-3	2022	As an inductor of cytochrome P450 3A4, a lack of vitamin D might aggravate cognitive deficits by increased exposure to anticholinergic antipsychotics.	Vitamin D	49-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-37
35625833-6	2022	Using regression analysis, we observed a positive relationship between vitamin D levels and processing speed (TMT-A and BACS Symbol Coding) as well as executive functioning (TMT-B and BACS Tower of London).	Vitamin D	71-80	solute carrier family 27 member 5	Homo sapiens	120-124
35625833-6	2022	Using regression analysis, we observed a positive relationship between vitamin D levels and processing speed (TMT-A and BACS Symbol Coding) as well as executive functioning (TMT-B and BACS Tower of London).	Vitamin D	71-80	solute carrier family 27 member 5	Homo sapiens	184-188
35600579-1	2022	Background: Vitamin D-dependant rickets type 1A (VDDR1A) is a rare autosomal recessive disorder caused by pathogenic variants in the CYP27B1 gene.	Vitamin D	12-21	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	133-140
34630965-0	2021	Effects of vitamin D supplementation on apolipoprotein A1 and B100 levels in adults: Systematic review and meta-analysis of controlled clinical trials.	Vitamin D	11-20	apolipoprotein A1	Homo sapiens	40-57
34630965-13	2021	However, significant increase in Apo A1 in daily dosage of vitamin D (SMD=0.56 mg/dL; 95% CI, 0.02, 1.11; P = 0.044) and <=12 weeks of supplementation duration (SMD=0.71 mg/dL; 95% CI, 0.08, 1.34; P = 0.028) was observed.	Vitamin D	59-68	apolipoprotein A1	Homo sapiens	33-39
34630965-15	2021	Overall, daily vitamin D supplementation and <=12 weeks of supplementation might have beneficial effects in increasing Apo A1 levels, however, future high-quality trials considering these a primary outcome are required.	Vitamin D	15-24	apolipoprotein A1	Homo sapiens	119-125
35507293-4	2022	The airway epithelium and alveolar macrophages express the enzyme, CYP27B1, that produces the active metabolite of vitamin D, 1,25(OH)2D, and the vitamin D receptor, VDR.	Vitamin D	115-124	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	67-74
35505326-7	2022	Sub-group analysis revealed that parathyroid hormone (PTH) concentration decreased and Calcium/creatinine ratio increased significantly in the combined vitamin D and Calcium group compared to the vitamin D alone or Calcium alone in contrast to the increase seen in the placebo group (p < 0.05 for between group difference at 6 months).	Vitamin D	152-161	parathyroid hormone	Homo sapiens	33-52
35505326-7	2022	Sub-group analysis revealed that parathyroid hormone (PTH) concentration decreased and Calcium/creatinine ratio increased significantly in the combined vitamin D and Calcium group compared to the vitamin D alone or Calcium alone in contrast to the increase seen in the placebo group (p < 0.05 for between group difference at 6 months).	Vitamin D	152-161	parathyroid hormone	Homo sapiens	54-57
35505326-9	2022	CONCLUSION: PTH concentration decreased and calcium/creatinine ratio increased in subjects who received vitamin D and Calcium together compared to those who received vitamin D alone.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	12-15
35535217-5	2022	In addition, vitamin D can also inhibit the secretion of T-helper type 1 (Th1) cytokines IFN-Y and IL-2 while stimulating the production of Th2 cytokines, thereby promoting wound healing.	Vitamin D	13-22	interferon gamma	Homo sapiens	89-94
35535217-5	2022	In addition, vitamin D can also inhibit the secretion of T-helper type 1 (Th1) cytokines IFN-Y and IL-2 while stimulating the production of Th2 cytokines, thereby promoting wound healing.	Vitamin D	13-22	interleukin 2	Homo sapiens	99-103
35334282-4	2022	The present study seeks to further confirm the internal relationship between vitamin D deficiency and I/R-induced AKI in patients, and to explore the underlying mechanisms of ROS, NF-kappaB signaling pathways and pyroptosis in the renal ischemia-reperfusion injury, as well as investigating the protective role of cholecalciferol.	Vitamin D	77-86	nuclear factor kappa B subunit 1	Homo sapiens	180-189
35102371-1	2022	BACKGROUND: Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes but circulating 25-hydroxyvitamin D (25(OH)D) is largely bound to vitamin D binding protein (DBP) or albumin both of which tend to fall in illness making 25(OH)D status hard to interpret.	Vitamin D	12-21	D-box binding PAR bZIP transcription factor	Homo sapiens	202-205
35102371-1	2022	BACKGROUND: Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes but circulating 25-hydroxyvitamin D (25(OH)D) is largely bound to vitamin D binding protein (DBP) or albumin both of which tend to fall in illness making 25(OH)D status hard to interpret.	Vitamin D	175-184	D-box binding PAR bZIP transcription factor	Homo sapiens	202-205
35279323-0	2022	Identification of vitamin D-dependent rickets type IA caused by a mutation of the CYP27B1 by whole exome sequencing.	Vitamin D	18-27	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	82-89
35166042-4	2022	METHODS: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4).	Vitamin D	27-36	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	56-63
35166042-6	2022	RESULTS: We found that vitamin D-activating enzyme CYP27B1 identified a subpopulation of astrocytes exclusively in PD patients.	Vitamin D	23-32	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	51-58
35247144-1	2022	PURPOSE: Vitamin D has been identified to have a relation to the development of insulin resistance-related diseases, such as type 2 diabetes (T2D).	Vitamin D	9-18	insulin	Homo sapiens	80-87
35443576-8	2022	The level of vitamin D was lower in diabetic patients in comparison to the controls and was significantly related to the severity of renal nephropathy as indicated by the level of albumin in urine.	Vitamin D	13-22	albumin	Homo sapiens	180-187
35339045-2	2022	Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway expressed by activated T helper (Th) cells have been identified as MS risk genes by genome-wide association studies, CYP27B1 (25(OH)D3 1-alpha-hydroxylase) and CYP24A1 (1,25(OH)2D3 24-alpha-hydroxylase).	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	267-274
35339045-2	2022	Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway expressed by activated T helper (Th) cells have been identified as MS risk genes by genome-wide association studies, CYP27B1 (25(OH)D3 1-alpha-hydroxylase) and CYP24A1 (1,25(OH)2D3 24-alpha-hydroxylase).	Vitamin D	132-141	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	267-274
35474468-5	2022	Furthermore, results from dual-luciferase reporting system exhibited that 1,25(OH)2 D3 directly activated the transcription of insra, rather than insrb in zebrafish by binding to vitamin D response element (VDRE) located at -181 to -167 bp in the promoter region of insra.	Vitamin D	179-188	insulin receptor a	Danio rerio	127-132
35474468-5	2022	Furthermore, results from dual-luciferase reporting system exhibited that 1,25(OH)2 D3 directly activated the transcription of insra, rather than insrb in zebrafish by binding to vitamin D response element (VDRE) located at -181 to -167 bp in the promoter region of insra.	Vitamin D	179-188	insulin receptor b	Danio rerio	146-151
35474468-5	2022	Furthermore, results from dual-luciferase reporting system exhibited that 1,25(OH)2 D3 directly activated the transcription of insra, rather than insrb in zebrafish by binding to vitamin D response element (VDRE) located at -181 to -167 bp in the promoter region of insra.	Vitamin D	179-188	insulin receptor a	Danio rerio	266-271
35254654-9	2022	Dual-luciferase assay confirmed that VDR could bind candidate vitamin D responsive elements (VDREs) in upstream region of Hsd3b1, and enhance gene expression.	Vitamin D	62-71	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Mus musculus	122-128
35400286-3	2022	This study aimed to evaluate the vitamin D (VD) immunomodulatory effect on the NLRP1/NLRP3 inflammasomes in placental explants from preeclamptic (PE) and normotensive (NT) pregnant women.	Vitamin D	33-42	NLR family pyrin domain containing 1	Homo sapiens	79-84
35400286-3	2022	This study aimed to evaluate the vitamin D (VD) immunomodulatory effect on the NLRP1/NLRP3 inflammasomes in placental explants from preeclamptic (PE) and normotensive (NT) pregnant women.	Vitamin D	33-42	NLR family pyrin domain containing 3	Homo sapiens	85-90
35403296-9	2022	After vitamin D supplementation for 90 days, T2DM patients had a 2-fold increase of GSH levels, from 2.72 +- 0.84 to 5.76 +- 3.19 mumol/ml, the concentration of MCP-1 decreased from 51.11 +- 20.86 to 25.42 +- 13.06 pg/ml, and IL-8 also decreased from 38.21 +- 21.76 to 16.05 +- 8.99 pg/ml.	Vitamin D	6-15	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
35403296-10	2022	In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP-1 and IL-8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM.	Vitamin D	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
35339636-0	2022	Peritoneal Restoration by Repurposing Vitamin D Inhibits Ovarian Cancer Dissemination via Blockade of the TGF-beta1/Thrombospondin-1 Axis.	Vitamin D	38-47	transforming growth factor beta 1	Homo sapiens	106-115
35339636-0	2022	Peritoneal Restoration by Repurposing Vitamin D Inhibits Ovarian Cancer Dissemination via Blockade of the TGF-beta1/Thrombospondin-1 Axis.	Vitamin D	38-47	thrombospondin 1	Homo sapiens	116-132
35339636-9	2022	Vitamin D inhibited mesenchymal transition in MCs and suppressed thrombospondin-1 expression via vitamin D receptor/Smad3 competition, contributing to the marked reduction in peritoneal dissemination in vivo.	Vitamin D	0-9	thrombospondin 1	Homo sapiens	65-81
35339636-10	2022	Importantly, vitamin D restored CAMs from a stabilized mesenchymal state to the epithelial state and normalized thrombospondin-1 expression in preclinical models that mimic cancerous peritonitis in vivo.	Vitamin D	13-22	thrombospondin 1	Homo sapiens	112-128
35339636-11	2022	CONCLUSIONS: MCs are key players in OvCa dissemination and peritoneal restoration and normalization of thrombospondin-1 expression by vitamin D may be a novel strategy for preventing OvCa dissemination.	Vitamin D	134-143	thrombospondin 1	Homo sapiens	103-119
35183675-0	2022	Vitamin D protects against high glucose-induced pancreatic beta-cell dysfunction via AMPK-NLRP3 inflammasome pathway.	Vitamin D	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	85-89
35183675-0	2022	Vitamin D protects against high glucose-induced pancreatic beta-cell dysfunction via AMPK-NLRP3 inflammasome pathway.	Vitamin D	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	90-95
35183675-13	2022	This study showed that vitamin D protects against high-glucose-induced beta-cell dysfunction by enhancing the AMPK pathway, thereby suppressing NLRP3 inflammasome activation.	Vitamin D	23-32	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	110-114
35183675-13	2022	This study showed that vitamin D protects against high-glucose-induced beta-cell dysfunction by enhancing the AMPK pathway, thereby suppressing NLRP3 inflammasome activation.	Vitamin D	23-32	NLR family, pyrin domain containing 3	Rattus norvegicus	144-149
35184385-5	2022	The results were confirmed in 3D spheroids, where 1alpha,25-dihydroxyvitamin D3 has comparable effect on CYP3A4 mRNA expression as 1alpha-hydroxyvitamin D3 , an active vitamin D metabolite.	Vitamin D	168-177	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111
35616893-1	2022	BACKGROUND: Several studies have reported the relevance between serum vitamin D and allergic immunoglobulin E (IgE) responses and atopic diseases.	Vitamin D	70-79	immunoglobulin heavy constant epsilon	Homo sapiens	111-114
35485213-15	2022	In conclusion, the meta-analysis of data from the largest collection to date of hypoparathyroid patients shows that PTH therapy is safe, well-tolerated and effective in normalizing serum phosphate and urinary calcium excretion, as well as enabling a reduction in calcium and vitamin D use and improving quality of life.	Vitamin D	275-284	parathyroid hormone	Homo sapiens	116-119
35488267-0	2022	Cholecalciferol supplementation lowers leptin and TMAO but increases NO and VEGF-A levels in obese vitamin D deficient patients: Is it one of the potential cardioprotective mechanisms of vitamin D?	Vitamin D	187-196	vascular endothelial growth factor A	Homo sapiens	76-82
35470763-7	2022	Our results demonstrated that maternal vitamin D deficiency increased anxiety and depression-related behaviors, increased levels of TNF-alpha and IL-1beta in serum, and decreased prefrontal protein expressions of BDNF and VDR in adult male offspring.	Vitamin D	39-48	tumor necrosis factor	Rattus norvegicus	132-141
35470763-7	2022	Our results demonstrated that maternal vitamin D deficiency increased anxiety and depression-related behaviors, increased levels of TNF-alpha and IL-1beta in serum, and decreased prefrontal protein expressions of BDNF and VDR in adult male offspring.	Vitamin D	39-48	interleukin 1 alpha	Rattus norvegicus	146-154
35547877-0	2022	Vitamin D Reverts the Exosome-Mediated Transfer of Cancer Resistance to the mTOR Inhibitor Everolimus in Hepatocellular Carcinoma.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Homo sapiens	76-80
35468187-0	2022	Response to Letter to the Editor from Chang Villacreses et al: "Effects of vitamin D supplementation on insulin sensitivity and secretion in prediabetes."	Vitamin D	75-84	insulin	Homo sapiens	104-111
35468193-1	2022	: "Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes".	Vitamin D	14-23	insulin	Homo sapiens	43-50
35446722-6	2022	Long-term (>6 months) activated vitamin D analogue therapy was required in five patients (4.3%), four of whom had normal serum PTH and one with undetectable PTH at 6 weeks post surgery.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	127-130
35446722-9	2022	We were able to identify all patients requiring activated vitamin D supplementation 6 months postoperatively from the day 1 postoperative serum calcium and PTH values, while excluding those that may only need temporary calcium supplementation.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	156-159
35462022-9	2022	Vitamin D supplementation is recommended from the onset as a transcription factor to improve VDR and CAMP gene expression in leprosy patients.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	101-105
35435056-2	2022	Aim: To determine the prevalence of vitamin D deficiency and investigate its association with body mass index (BMI), waist circumference, and serum concentrations of parathyroid hormone, calcium, and phosphorus in a sample of Moroccan adult women.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	166-185
35458206-5	2022	Vitamin D deficiency was found in 67.2% and was independent of sex, disease manifestation, and CRP, ESR, ALP, or PO4 levels.	Vitamin D	0-9	C-reactive protein	Homo sapiens	95-98
35458206-5	2022	Vitamin D deficiency was found in 67.2% and was independent of sex, disease manifestation, and CRP, ESR, ALP, or PO4 levels.	Vitamin D	0-9	alkaline phosphatase, placental	Homo sapiens	105-108
35464768-9	2022	Patients with resistance to long-acting EPO have a significantly lower hemoglobin concentration in the blood, hematocrit values, and serum concentration of prealbumin and vitamin D, as well as significantly higher concentration of C-reactive protein, superoxide anion, and hydrogen peroxide concentration than those without resistance.	Vitamin D	171-180	erythropoietin	Homo sapiens	40-43
35464768-11	2022	OS, higher ferritin and CRP levels, lower hemoglobin, hematocrit and prealbumin levels, and vitamin D deficiency represent significant risk factors for EPO resistance development in HD patients.	Vitamin D	92-101	erythropoietin	Homo sapiens	152-155
35498406-0	2022	Vitamin D Reduces Thyroid Cancer Cells Migration Independently From the Modulation of CCL2 and CXCL8 Chemokines Secretion.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
35498406-5	2022	The aim of the present study was to investigate if vitamin D could modulate both thyroid cancer cell migration and their ability to secrete CCL2 and CXCL8.	Vitamin D	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	149-154
35498406-8	2022	Results: Vitamin D did not affect cell viability but reduced, in a dose-dependent and significant manner, thyroid cancer cell migration (ANOVAs p < 0.05 for both TPC-1 and 8505C).	Vitamin D	9-18	two pore segment channel 1	Homo sapiens	162-167
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	181-186
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	two pore segment channel 1	Homo sapiens	195-200
35498406-11	2022	Future studies specifically designed at clarifying the pathways involved in the different inhibitory effects of vitamin D on CCL2 and CXCL8 in thyroid cancer cells appear worthwhile.	Vitamin D	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	134-139
35458179-7	2022	Adjusted regression models identified an association between higher caffeine intake and lower ALP level only among vitamin D-sufficient pregnant women (beta = -0.24, p = 0.006), but not in those with insufficient vitamin D (beta = -0.02, p = 0.912).	Vitamin D	115-124	alkaline phosphatase, placental	Homo sapiens	94-97
35464031-6	2022	Maternal vitamin D deficiency has been associated with an elevated risk of GDM, and supplementation can improve glucose haemostasis by lowering fasting blood glucose, HbA1c, and serum insulin concentration.	Vitamin D	9-18	insulin	Homo sapiens	184-191
35437440-0	2022	Occult Renal Calcifications in Patients with Normocalcemic Primary Hyperparathyroidism and Their Association with the Parathyroid Hormone-Vitamin D Axis.	Vitamin D	138-147	parathyroid hormone	Homo sapiens	118-137
35510205-13	2022	However, sex, age, socioeconomic level, phototype, solar exposure score, smoking and bone mass index, were not statistically associated with hypovitaminosis D. The study of relationship between vitamin D status and serum PTH levels showed a significative and negative correlation (P < 0.005).	Vitamin D	194-203	parathyroid hormone	Homo sapiens	221-224
35388768-13	2022	Both phytochemicals and vitamin D prevent the/ production of proinflammatory cytokine TNF-alpha that is responsible for inflammation and lung diseases.	Vitamin D	24-33	tumor necrosis factor	Homo sapiens	86-95
35415272-11	2022	Serum concentrations of vitamin D were positively correlated with levels of serum calcium, lymphocytes, and neutrophils but negatively correlated with CRP, fibrinogen, and d-dimer values.	Vitamin D	24-33	C-reactive protein	Homo sapiens	151-154
35415272-11	2022	Serum concentrations of vitamin D were positively correlated with levels of serum calcium, lymphocytes, and neutrophils but negatively correlated with CRP, fibrinogen, and d-dimer values.	Vitamin D	24-33	fibrinogen beta chain	Homo sapiens	156-166
35444957-3	2022	This study examines the role of vitamin D deficiency in the regulation of Cathelicidin Antimicrobial Peptide (CAMP) in CD-like macrophages.	Vitamin D	32-41	cathelicidin antimicrobial peptide	Homo sapiens	110-114
35444957-14	2022	Altogether, the data indicate that MAP infection and burden is significant in CD by disrupting the conversion of calcifediol to calcitriol and downregulation of CAMP expression leading to vitamin D deficiency.	Vitamin D	188-197	cathelicidin antimicrobial peptide	Homo sapiens	161-165
35500429-8	2022	The levels of IL-1beta, TNF-alpha, and NF-kB p65 in knee OA patients with vitamin D insufficiency were significantly higher compared with the knee OA patients with sufficient vitamin D (P < 0.05).	Vitamin D	74-83	tumor necrosis factor	Homo sapiens	24-33
35500429-9	2022	Based on the linear regression analysis, serum vitamin D levels were inversely correlated with IL-1beta, TNF-alpha, hs-CRP, and NF-kB p65 levels (P < 0.0001).	Vitamin D	47-56	tumor necrosis factor	Homo sapiens	105-114
35565811-2	2022	The primary aim of this study was to determine the associations between serum, dietary, and supplemental vitamin D levels and insulin resistance in 6294 non-diabetic U.S. adults.	Vitamin D	105-114	insulin	Homo sapiens	126-133
35565811-12	2022	With all the covariates controlled, the odds of having insulin resistance were significantly greater for those in the lowest quartile of serum and supplemental vitamin D intake compared to the other quartiles combined.	Vitamin D	160-169	insulin	Homo sapiens	55-62
35565811-13	2022	In conclusion, in this nationally representative sample, serum, dietary, and supplemental vitamin D were each predictive of insulin resistance, especially in those with low serum levels and those with no supplemental intake of vitamin D.	Vitamin D	90-99	insulin	Homo sapiens	124-131
35565811-13	2022	In conclusion, in this nationally representative sample, serum, dietary, and supplemental vitamin D were each predictive of insulin resistance, especially in those with low serum levels and those with no supplemental intake of vitamin D.	Vitamin D	227-236	insulin	Homo sapiens	124-131
35443576-9	2022	Moreover, vitamin D levels showed significant negative correlation with the inflammatory markers: TNF-alpha, CRP, and HIF-1alpha levels.	Vitamin D	10-19	tumor necrosis factor	Homo sapiens	98-107
35443576-9	2022	Moreover, vitamin D levels showed significant negative correlation with the inflammatory markers: TNF-alpha, CRP, and HIF-1alpha levels.	Vitamin D	10-19	C-reactive protein	Homo sapiens	109-112
35443576-9	2022	Moreover, vitamin D levels showed significant negative correlation with the inflammatory markers: TNF-alpha, CRP, and HIF-1alpha levels.	Vitamin D	10-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
35443443-14	2022	A weak negative correlation of IL-1 and TNF-alpha was seen with vitamin D in diabetics without nephropathy, whereas IL-6 had a weak negative correlation with vitamin D in diabetics with nephropathy.	Vitamin D	64-73	tumor necrosis factor	Homo sapiens	40-49
35443443-14	2022	A weak negative correlation of IL-1 and TNF-alpha was seen with vitamin D in diabetics without nephropathy, whereas IL-6 had a weak negative correlation with vitamin D in diabetics with nephropathy.	Vitamin D	158-167	interleukin 6	Homo sapiens	116-120
35122668-13	2022	Regardless of vitamin D supplementation, participants with severe vitamin D deficiency had significantly higher intact parathyroid hormone levels and lower bone mineral content.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	119-138
35516667-7	2022	Therefore, for any patient presenting with persistent vomiting, altered sensorium, and hypercalcemia, with normal to low parathyroid hormone levels, a diagnosis of an overdose of vitamin D should be considered.	Vitamin D	179-188	parathyroid hormone	Homo sapiens	121-140
35438528-0	2022	Vitamin D Attenuates Airway Inflammation in Asthmatic Guinea Pigs Using Mammalian Target of Rapamycin-Mediated Autophagy.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Homo sapiens	72-101
35438528-1	2022	The purpose of this experiment is to find out the function of Vitamin D (VD) in airway inflammation in asthmatic guinea pigs by regulating mammalian target of rapamycin (mTOR)-mediated autophagy.	Vitamin D	62-71	mechanistic target of rapamycin kinase	Homo sapiens	139-168
35438528-1	2022	The purpose of this experiment is to find out the function of Vitamin D (VD) in airway inflammation in asthmatic guinea pigs by regulating mammalian target of rapamycin (mTOR)-mediated autophagy.	Vitamin D	62-71	mechanistic target of rapamycin kinase	Homo sapiens	170-174
35099571-11	2022	In severe COVID-19 cases, vitamin D supplementation may inhibit the increase of PD-L1 expression through reducing proinflammatory cytokine levels.	Vitamin D	26-35	CD274 molecule	Sus scrofa	80-85
35099571-12	2022	Thus, vitamin D supplementation could eliminate the suppressive effect of PD-L1 on CD4+ and CD8+ T cells, preventing lymphopenia and reducing disease severity and mortality in patients infected with COVID-19.	Vitamin D	6-15	CD4 molecule	Homo sapiens	83-86
35091041-4	2022	Vitamin D is a known inhibitor of NF-kappaB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	34-43
34989171-10	2022	In addition, the serum inflammation factors (CRP, IL6, and TNF-alpha) were significantly reduced by vitamin D supplementation.	Vitamin D	100-109	C-reactive protein	Homo sapiens	45-48
34989171-10	2022	In addition, the serum inflammation factors (CRP, IL6, and TNF-alpha) were significantly reduced by vitamin D supplementation.	Vitamin D	100-109	interleukin 6	Homo sapiens	50-53
34989171-10	2022	In addition, the serum inflammation factors (CRP, IL6, and TNF-alpha) were significantly reduced by vitamin D supplementation.	Vitamin D	100-109	tumor necrosis factor	Homo sapiens	59-68
35091041-4	2022	Vitamin D is a known inhibitor of NF-kappaB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice.	Vitamin D	64-73	nuclear factor kappa B subunit 1	Homo sapiens	34-43
35091041-4	2022	Vitamin D is a known inhibitor of NF-kappaB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice.	Vitamin D	64-73	methyl-CpG binding protein 2	Homo sapiens	123-128
35091041-5	2022	We previously demonstrated that vitamin D rescues the aberrant NF-kappaB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo.	Vitamin D	32-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
35091041-5	2022	We previously demonstrated that vitamin D rescues the aberrant NF-kappaB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo.	Vitamin D	175-184	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
35091881-4	2022	Airway epithelia constitutively expresses CYP27B1, the enzyme producing the active vitamin D metabolite, 1,25(OH)2D, and the vitamin D receptor (VDR) for which 1,25(OH)2D is the ligand.	Vitamin D	83-92	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	42-49
35392498-0	2022	Vitamin D is Positively Associated with Bone Mineral Density Muscle Mass and Negatively with Insulin Resistance in Senile Diabetes Mellitus.	Vitamin D	0-9	insulin	Homo sapiens	93-100
35425790-1	2022	Background: Some studies have shown that, the circulating vitamin D (Vit D) concentration in the body exerts a crucial role in regulating the pancreatic beta-cell function.	Vitamin D	58-67	vitrin	Homo sapiens	69-72
35409134-1	2022	Parathyroid hormone (PTH) is a key regulator of calcium, phosphate and vitamin D metabolism.	Vitamin D	71-80	parathyroid hormone	Homo sapiens	21-24
35515959-1	2022	Objectives: In the present study, we investigated the effects of Vitamin D (vit D) deficiency on aggressiveness of papillary thyroid cancer (PTC).	Vitamin D	65-74	vitrin	Homo sapiens	76-79
35369303-6	2022	According to the common view, Insulin resistance is considered the direct or indirect consequence of vitamin D deficiency.	Vitamin D	101-110	insulin	Homo sapiens	30-37
35478388-7	2022	Vitamin D reduces cytokine levels through regulation of the extracellular signal-related kinase 1/2 and Toll-like receptor 1/2 pathways, along with the suppression of interleukin expression.	Vitamin D	0-9	mitogen-activated protein kinase 3	Homo sapiens	60-99
35478388-7	2022	Vitamin D reduces cytokine levels through regulation of the extracellular signal-related kinase 1/2 and Toll-like receptor 1/2 pathways, along with the suppression of interleukin expression.	Vitamin D	0-9	toll like receptor 1	Homo sapiens	104-126
35410821-3	2022	The serum 25(OH)D value at which parathyroid hormone level plateaus, called the "inflection point," is considered the most appropriate criterion for defining an adequate vitamin D status.	Vitamin D	170-179	parathyroid hormone	Homo sapiens	33-52
35369303-7	2022	However, it is also reasonable to speculate that the deficit or the impaired action of vitamin D, in some circumstances, could be the result of the same pathogenic mechanisms responsible of insulin resistance development.	Vitamin D	87-96	insulin	Homo sapiens	190-197
35369303-8	2022	In this case, vitamin D deficiency could be considered an epiphenomenon of insulin resistance.	Vitamin D	14-23	insulin	Homo sapiens	75-82
35369303-11	2022	These findings indicate that improving insulin resistance condition is a necessary step to ameliorate vitamin D supplementation-based strategies in cardiovascular prevention.	Vitamin D	102-111	insulin	Homo sapiens	39-46
35288591-12	2022	We speculated that a combination of different factors, including reduced sun exposure, possibly associated with reduced serum vitamin D levels, and poor physical activity, concur to the impaired bone status in NF1 patients.	Vitamin D	126-135	neurofibromin 1	Homo sapiens	210-213
35288591-13	2022	We also demonstrated that treatment with vitamin D can be effective in improving z-score value in NF1 patients, including children.	Vitamin D	41-50	neurofibromin 1	Homo sapiens	98-101
35218642-7	2022	Higher levels of vitamin D can increase levels of anti-inflammatory mediators, CD4+ T lymphocytes and CD8+ T lymphocytes and CD3+ T lymphocytes in intratumoral tissue.	Vitamin D	17-26	CD4 molecule	Homo sapiens	79-82
35356738-0	2022	Corrigendum: Effects of Vitamin D and K on Interleukin-6 in COVID-19.	Vitamin D	24-33	interleukin 6	Homo sapiens	43-56
35256680-6	2022	SNPs for CYP27B1 (CA & CC genotype) had statistically significant positive association (beta = 1.61; 95% CI 2.79, 0.42; p-value < 0.05) and TT genotype of GC-rs7041 had negative association (beta =  - 1.33; 95% CI - 0.02, - 2.64; p-value < 0.05) with vitamin-D deficiency in the surveyed children.	Vitamin D	251-260	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	9-16
35091316-1	2022	BACKGROUND AND AIMS: There have been plenty of reports regarding the association between Vitamin D (Vit D) and carotid atherosclerosis and stroke.	Vitamin D	89-98	vitrin	Homo sapiens	100-103
35148579-7	2022	However, mean values for MetS and NMetS showed age-wise lowering in vitamin D and highly significant negative linear correlation of age and vitD for MetS (R: -0.508, p <0.001) and NMetS (R: -0.522, p <0.001).	Vitamin D	68-77	renin binding protein	Homo sapiens	47-50
35148579-8	2022	CONCLUSION: Present report, emphasising the significant negative linear correlation of age with serum vitD levels in MetS and NMetS subjects, provides potential information for understanding the discomforts caused by the insufficiency of vitamin D with the increase in age.	Vitamin D	238-247	renin binding protein	Homo sapiens	87-90
35148579-8	2022	CONCLUSION: Present report, emphasising the significant negative linear correlation of age with serum vitD levels in MetS and NMetS subjects, provides potential information for understanding the discomforts caused by the insufficiency of vitamin D with the increase in age.	Vitamin D	238-247	renin binding protein	Homo sapiens	269-272
35277211-8	2022	There was a negative correlation between vitamin D status and CRP levels (=-.364, p=.007).	Vitamin D	41-50	C-reactive protein	Homo sapiens	62-65
35213796-0	2022	Histopathological role of vitamin D deficiency in recurrent/chronic tonsillitis pathogenesis: Vascular epithelial growth factor-mediated angiogenesis in tonsil.	Vitamin D	26-35	vascular endothelial growth factor A	Homo sapiens	94-127
35202418-13	2022	The study displayed the short-term effect of Vitamin D supplementation on vitamin D, PTH levels, LTL and vitamin D associated gene expressions.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	85-88
35345711-3	2022	Several studies have shown that vitamin D supplements reduce insulin resistance in T2DM and improve insulin secretion and sensitivity.	Vitamin D	32-41	insulin	Homo sapiens	61-68
35345711-3	2022	Several studies have shown that vitamin D supplements reduce insulin resistance in T2DM and improve insulin secretion and sensitivity.	Vitamin D	32-41	insulin	Homo sapiens	100-107
35202418-9	2022	After vitamin D supplementation 25(OH)D, 1,25(OH)2D, PTH and VDBP levels were changed significantly compared to the placebo group.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	53-56
35265081-6	2022	Treatment with metformin and vitamin D reduces HG-enhanced expression of TRAIL in CTLs and coherently protects 1.4E7 cells from TRAIL-mediated apoptosis.	Vitamin D	29-38	TNF superfamily member 10	Homo sapiens	73-78
35265081-6	2022	Treatment with metformin and vitamin D reduces HG-enhanced expression of TRAIL in CTLs and coherently protects 1.4E7 cells from TRAIL-mediated apoptosis.	Vitamin D	29-38	TNF superfamily member 10	Homo sapiens	128-133
35216451-3	2022	Interestingly, many patients with type 2 diabetes mellitus (T2DM) and insulin resistance have been found to be deficient in vitamin D.	Vitamin D	124-133	insulin	Homo sapiens	70-77
35242790-2	2021	Previous studies reported that low vitamin D status and decreased kidney function were associated with insulin resistance (IR).	Vitamin D	35-44	insulin	Homo sapiens	103-110
35206632-2	2022	In the pathogenesis of insulin-resistance-related diseases, including obesity and diabetes, Vitamin D deficiency is very common.	Vitamin D	92-101	insulin	Homo sapiens	23-30
35252193-4	2022	In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related gamma-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation.	Vitamin D	27-36	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	63-68
35223754-0	2021	Vitamin D Status Is Negatively Related to Insulin Resistance and Bone Turnover in Chinese Non-Osteoporosis Patients With Type 2 Diabetes: A Retrospective Cross-Section Research.	Vitamin D	0-9	insulin	Homo sapiens	42-49
35204769-0	2022	High Vitamin D Concentrations Restore the Ability to Express LL37 by M. tuberculosis-Infected Human Macrophages.	Vitamin D	5-14	cathelicidin antimicrobial peptide	Homo sapiens	61-65
35204769-6	2022	This study aimed to evaluate the vitamin D contribution in the expression of VDR and CYP27B1, involved in the conversion of an inactive to an active form of vitamin D in the infected macrophages using M. tuberculosis as an infection model.	Vitamin D	33-42	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	85-92
35204769-6	2022	This study aimed to evaluate the vitamin D contribution in the expression of VDR and CYP27B1, involved in the conversion of an inactive to an active form of vitamin D in the infected macrophages using M. tuberculosis as an infection model.	Vitamin D	157-166	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	85-92
35204769-7	2022	The expression of LL37 and the nucleus translocation of VDR were evaluated as the readout of the response of vitamin D and determined if those processes are affected by glucose concentrations.	Vitamin D	109-118	cathelicidin antimicrobial peptide	Homo sapiens	18-22
35204769-9	2022	The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA.	Vitamin D	4-13	cathelicidin antimicrobial peptide	Homo sapiens	37-41
35204769-9	2022	The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA.	Vitamin D	4-13	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	72-79
35204769-11	2022	After evaluating two concentrations of vitamin D, 1 nM or 1 muM, the high concentration (1 muM) was necessary to restore the induction of LL37 expression in M. tuberculosis-infected macrophages.	Vitamin D	39-48	cathelicidin antimicrobial peptide	Homo sapiens	138-142
35204769-12	2022	High concentrations of the inactive form of vitamin D restore the infected macrophages" ability to express LL37 regardless of the glucose concentration.	Vitamin D	44-53	cathelicidin antimicrobial peptide	Homo sapiens	107-111
32345077-4	2022	In addition, the mean serum level of IL6, hsCRP and TNFalpha significantly decreased in the study group in comparison to the placebo group and as compared to their baseline results.Conclusion: Vitamin D deficiency is more common in CSU patients as compared to healthy people and hence, alfacalcidol might have a beneficial role as add on therapy in CSU management with no reported side effects.	Vitamin D	193-202	interleukin 6	Homo sapiens	37-40
32345077-4	2022	In addition, the mean serum level of IL6, hsCRP and TNFalpha significantly decreased in the study group in comparison to the placebo group and as compared to their baseline results.Conclusion: Vitamin D deficiency is more common in CSU patients as compared to healthy people and hence, alfacalcidol might have a beneficial role as add on therapy in CSU management with no reported side effects.	Vitamin D	193-202	tumor necrosis factor	Homo sapiens	52-60
35093020-1	2022	BACKGROUND: Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension.	Vitamin D	12-21	vitrin	Homo sapiens	23-26
35132380-0	2022	Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling.	Vitamin D	15-24	thymoma viral proto-oncogene 1	Mus musculus	83-86
35078844-10	2022	In January 2020, the facilities" median weekly doses of erythropoietin stimulating agent (ESA) and of intravenous vitamin D ranged from 1846 to 9692 IU (epoetin alfa equivalent) and 0.78 to 2.25 microg (calcitriol equivalent), respectively.	Vitamin D	114-123	erythropoietin	Homo sapiens	153-160
35045292-5	2022	We show that JAK2-mediated STAT3 phosphorylation is specific to vitamin D stimulation.	Vitamin D	64-73	signal transducer and activator of transcription 3	Homo sapiens	27-32
35115928-2	2021	We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4+ recovery in naive HIV-infected patients who started ART with low baseline CD4+.	Vitamin D	94-103	CD4 molecule	Homo sapiens	123-126
35115928-2	2021	We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4+ recovery in naive HIV-infected patients who started ART with low baseline CD4+.	Vitamin D	94-103	CD4 molecule	Homo sapiens	202-205
35055118-1	2022	The purpose of the study was to investigate the role of vitamin D binding protein (VDBP, DBP) and its polymorphism in the vitamin D pathway and human health.	Vitamin D	122-131	D-box binding PAR bZIP transcription factor	Homo sapiens	89-92
35055093-5	2022	Functional analysis indicated vitamin D"s role in the suppression of the inflammatory and adaptive immune response by down-regulating ten major histocompatibility complex class II genes, five alarmins of the S100 calcium binding protein A family and by affecting six chemokines of the C-X-C motif ligand family.	Vitamin D	30-39	S100 calcium binding protein A1	Homo sapiens	208-212
35050236-0	2022	Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?	Vitamin D	0-9	interleukin 6	Homo sapiens	19-23
35096715-0	2021	Screen Time, Age and Sunshine Duration Rather Than Outdoor Activity Time Are Related to Nutritional Vitamin D Status in Children With ASD.	Vitamin D	100-109	renin binding protein	Homo sapiens	13-16
35096715-5	2021	The vitamin D concentration in the children with ASD was negatively correlated with screen time and age and positively correlated with sunshine duration.	Vitamin D	4-13	renin binding protein	Homo sapiens	100-103
35096715-6	2021	Conclusion: The vitamin D levels in children with ASD are related to electronic screen time, age and sunshine duration.	Vitamin D	16-25	renin binding protein	Homo sapiens	93-96
34550329-12	2022	CONCLUSIONS: Vitamin D supplementation demonstrated generally positive effects on HDLc, LDLc and cholesterol, especially at the lower dose of 600 IU, with several significant changes persisting during the post-supplementation period.	Vitamin D	13-22	component of oligomeric golgi complex 2	Homo sapiens	88-92
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	defensin beta 4A	Homo sapiens	37-52
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	defensin beta 4A	Homo sapiens	53-67
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	defensin beta 4A	Homo sapiens	69-73
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	defensin beta 4A	Homo sapiens	74-79
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	cathelicidin antimicrobial peptide	Homo sapiens	85-119
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	cathelicidin antimicrobial peptide	Homo sapiens	121-125
35057447-11	2022	In individuals with chronic pain, based on clinical categories, significant associations between vitamin D, omega 6:3 ratio, and CRP were observed.	Vitamin D	97-106	C-reactive protein	Homo sapiens	129-132
35027842-2	2022	There are limited data and controversies regarding the relationship between vitamin D (Vit D) status and COVID-19 disease.	Vitamin D	76-85	vitrin	Homo sapiens	87-90
34991572-12	2022	CONCLUSION: Older subjects with vitamin D deficiency have increased BMI, inflammation and PTH compared with those with insufficiency or optimal concentrations.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	90-93
34985728-3	2022	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)D), has been shown to induce the CAMP gene expression through promoter activation.	Vitamin D	19-28	cathelicidin antimicrobial peptide	Homo sapiens	96-100
35096006-9	2021	Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6.	Vitamin D	75-84	phosphodiesterase 4B	Homo sapiens	154-159
34873890-8	2022	CONCLUSION: Cow"s milk protein in the diet was associated with increased intake of energy, proteins, carbohydrates, calcium, phosphorus, and vitamin D, in addition to an increase in the Z-scores for weight-for-age and height-for-age.	Vitamin D	141-150	casein beta	Bos taurus	18-30
35166102-2	2022	This study aims to assess the serum vitamin D level and its relationship with cluster for differentiation; CD4+T cells among HIV infected individuals on HAART.	Vitamin D	36-45	CD4 molecule	Homo sapiens	107-110
35166102-11	2022	CD4 count was associated with the level of serum vitamin D, p-value < 0.05.	Vitamin D	49-58	CD4 molecule	Homo sapiens	0-3
35166102-13	2022	Our study found a significant correlation between serum vitamin D level and CD4 counts.	Vitamin D	56-65	CD4 molecule	Homo sapiens	76-79
35166102-14	2022	It may be concluded that highly antiretroviral therapy HAART, improves CD4 level when there is sufficient vitamin D level, however, this merits further extensive exploration.	Vitamin D	106-115	CD4 molecule	Homo sapiens	71-74
35174689-12	2022	Chitosan can reduce blood pressure, while vitamin D improves the sensitivity of tissue to insulin.	Vitamin D	42-51	insulin	Homo sapiens	90-97
35576543-1	2022	OBJECTIVES: This study is aimed to determine the relationship between 25-OH vitamin D levels, inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), c-reactive protein (CRP) levels and the disease severity of COVID-19 infection.	Vitamin D	76-85	C-reactive protein	Homo sapiens	195-213
34586223-0	2022	Association between age-related macular degeneration and 25(OH) vitamin D levels in the Turkish population.	Vitamin D	64-73	renin binding protein	Homo sapiens	20-23
34586223-2	2022	This study was conducted to explore the relationship between serum vitamin D levels and age-related macular degeneration.	Vitamin D	67-76	renin binding protein	Homo sapiens	88-91
34586223-9	2022	RESULTS: The 25(OH) vitamin D levels in age- and gender-matched patients with age-related macular degeneration and in healthy subjects were 14.6 +- 9.8 and 29.14 +- 15.1 ng/ml, respectively.	Vitamin D	20-29	renin binding protein	Homo sapiens	40-43
34586223-9	2022	RESULTS: The 25(OH) vitamin D levels in age- and gender-matched patients with age-related macular degeneration and in healthy subjects were 14.6 +- 9.8 and 29.14 +- 15.1 ng/ml, respectively.	Vitamin D	20-29	renin binding protein	Homo sapiens	78-81
34586223-10	2022	The age-related macular degeneration group had significantly lower vitamin D levels than the control group (p>0.001).	Vitamin D	67-76	renin binding protein	Homo sapiens	4-7
34586223-13	2022	When the level of 25(OH) vitamin D was evaluated according to the stages of age-related macular degeneration, it was found to be lower in the advanced-stage disease (p=0.01).	Vitamin D	25-34	renin binding protein	Homo sapiens	76-79
34586223-15	2022	CONCLUSIONS: Significantly decreased levels of 25(OH) vitamin D in advanced-stage age-related macular degeneration suggest a significant correlation existing between vitamin D deficiency and age-related macular degeneration development.	Vitamin D	54-63	renin binding protein	Homo sapiens	82-85
34586223-15	2022	CONCLUSIONS: Significantly decreased levels of 25(OH) vitamin D in advanced-stage age-related macular degeneration suggest a significant correlation existing between vitamin D deficiency and age-related macular degeneration development.	Vitamin D	54-63	renin binding protein	Homo sapiens	191-194
34586223-15	2022	CONCLUSIONS: Significantly decreased levels of 25(OH) vitamin D in advanced-stage age-related macular degeneration suggest a significant correlation existing between vitamin D deficiency and age-related macular degeneration development.	Vitamin D	166-175	renin binding protein	Homo sapiens	191-194
34586223-16	2022	Further studies are required to examine whether vitamin D supplementation has an effect on the development and progression of age-related macular degeneration.	Vitamin D	48-57	renin binding protein	Homo sapiens	126-129
35576543-1	2022	OBJECTIVES: This study is aimed to determine the relationship between 25-OH vitamin D levels, inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), c-reactive protein (CRP) levels and the disease severity of COVID-19 infection.	Vitamin D	76-85	C-reactive protein	Homo sapiens	215-218
34473295-0	2022	Effects of vitamin D supplementation on insulin sensitivity and secretion in prediabetes.	Vitamin D	11-20	insulin	Homo sapiens	40-47
34473295-1	2022	CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on insulin sensitivity and beta-cell function remain unclear.	Vitamin D	9-18	insulin	Homo sapiens	103-110
34473295-1	2022	CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on insulin sensitivity and beta-cell function remain unclear.	Vitamin D	74-83	insulin	Homo sapiens	103-110
34508607-0	2022	Vitamin D supplementation improves fasting insulin levels and HDL cholesterol in infertile men.	Vitamin D	0-9	insulin	Homo sapiens	43-50
34508607-7	2022	RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH).	Vitamin D	23-32	parathyroid hormone	Homo sapiens	171-190
34347093-7	2022	RESULTS: By Week 26, 91% of subjects treated with TransCon PTH achieved independence from standard of care (SoC, defined as active vitamin D = 0 mcg/day and calcium (Ca) <= 500 mg/day).	Vitamin D	131-140	parathyroid hormone	Homo sapiens	59-62
34508607-7	2022	RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH).	Vitamin D	23-32	parathyroid hormone	Homo sapiens	192-195
34508607-7	2022	RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH).	Vitamin D	88-97	parathyroid hormone	Homo sapiens	171-190
34508607-7	2022	RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH).	Vitamin D	88-97	parathyroid hormone	Homo sapiens	192-195
34508607-8	2022	At end of trial, men receiving vitamin D supplementation had 13% lower fasting serum insulin concentrations compared with the placebo-treated group (65 vs. 74 pmol/L, P = 0.018) and 19% lower HOMA-IR (2.2 vs. 2.7, P = 0.025).	Vitamin D	31-40	insulin	Homo sapiens	85-92
35228490-12	2022	The serum C-reactive protein showed significant reduction (p=0.028*) after intervention with vitamin D.	Vitamin D	93-102	C-reactive protein	Homo sapiens	10-28
35228490-14	2022	It was concluded that a single large dose of vitamin D was able to reduce the C-reactive protein in non-ST-elevation acute coronary syndrome patients while non-significant reductions in interleukin-6 and tumor necrosis factor-alpha were observed.	Vitamin D	45-54	C-reactive protein	Homo sapiens	78-96
35228490-14	2022	It was concluded that a single large dose of vitamin D was able to reduce the C-reactive protein in non-ST-elevation acute coronary syndrome patients while non-significant reductions in interleukin-6 and tumor necrosis factor-alpha were observed.	Vitamin D	45-54	interleukin 6	Homo sapiens	186-199
35228490-14	2022	It was concluded that a single large dose of vitamin D was able to reduce the C-reactive protein in non-ST-elevation acute coronary syndrome patients while non-significant reductions in interleukin-6 and tumor necrosis factor-alpha were observed.	Vitamin D	45-54	tumor necrosis factor	Homo sapiens	204-231
2594036-0	1989	Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	53-72
35379386-10	2022	Meta-analysis showed that patients that were vitamin D sufficient (levels >30ng/mL) had statistically significant lower levels of IL-6, CRP, ferritin, LDH, fibrinogen, and D-dimer compared to vitamin D deficient group.	Vitamin D	45-54	interleukin 6	Homo sapiens	130-134
35379386-10	2022	Meta-analysis showed that patients that were vitamin D sufficient (levels >30ng/mL) had statistically significant lower levels of IL-6, CRP, ferritin, LDH, fibrinogen, and D-dimer compared to vitamin D deficient group.	Vitamin D	45-54	C-reactive protein	Homo sapiens	136-139
35379386-10	2022	Meta-analysis showed that patients that were vitamin D sufficient (levels >30ng/mL) had statistically significant lower levels of IL-6, CRP, ferritin, LDH, fibrinogen, and D-dimer compared to vitamin D deficient group.	Vitamin D	45-54	fibrinogen beta chain	Homo sapiens	156-166
35079680-0	2022	Vitamin D Modulation of Mitochondrial Oxidative Metabolism and mTOR Enforces Stress Adaptations and Anticancer Responses.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Homo sapiens	63-67
2594036-3	1989	The overall inverse relation between serum parathyroid hormone and 25(OH)D levels was found to be dependent on vitamin D intake.	Vitamin D	111-120	parathyroid hormone	Homo sapiens	43-62
2594036-4	1989	In women whose estimated intake of vitamin D was less than or equal to 220 IU a day, the mean (+/- SD) serum parathyroid hormone values were lowest in those studied between August and October (30 +/- 11 ng per liter; n = 72) and highest in those studied between March and May (37 +/- 16 ng per liter; n = 54); the respective serum 25(OH)D levels were 93 +/- 32 and 63 +/- 21 nmol per liter.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	109-128
2594036-9	1989	We conclude that the dietary intake of more than 220 IU of vitamin D a day by postmenopausal women in Massachusetts may be sufficient to maintain constant serum 25(OH)D and parathyroid hormone concentrations throughout the year.	Vitamin D	59-68	parathyroid hormone	Homo sapiens	173-192
2551904-4	1989	Administration of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3; 25 ng/day for 7 days) to vitamin D-deficient rats resulted in an increase in calbindin mRNA in intestine and kidney but no change in VDR mRNA in these tissues.	Vitamin D	32-41	calbindin 1	Rattus norvegicus	134-143
2699996-0	1989	Insulin secretion in uremia: effect of parathyroid hormone and vitamin D metabolites.	Vitamin D	63-72	insulin	Homo sapiens	0-7
2559250-0	1989	Effect of vitamin D3 administration on serum 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and osteocalcin in vitamin D-deficient elderly people.	Vitamin D	10-19	bone gamma-carboxyglutamate protein	Homo sapiens	96-107
2585144-1	1989	Plasma levels of vitamin D-binding protein (DBP) and vitamin D metabolites in patients with decompensated and compensated liver cirrhosis were assayed.	Vitamin D	17-26	D-box binding PAR bZIP transcription factor	Homo sapiens	44-47
2505903-2	1989	Calcitonin inhibits the function of osteoclasts, reducing bone resorption, thus, the combination of vitamin D and calcitonin could result in a positive bone balance.	Vitamin D	100-109	calcitonin related polypeptide alpha	Homo sapiens	0-10
2552296-0	1989	Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.	Vitamin D	22-31	bone gamma-carboxyglutamate protein	Homo sapiens	43-54
2788385-0	1989	Is intact PTH a sensitive biochemical indicator of deranged calcium homeostasis in vitamin D deficiency?	Vitamin D	83-92	parathyroid hormone	Homo sapiens	10-13
2788385-2	1989	Changes in intact PTH were disproportionately greater than for other biochemical parameters, making it the most sensitive early indicator of deranged calcium homeostasis in vitamin D deficiency.	Vitamin D	173-182	parathyroid hormone	Homo sapiens	18-21
2548645-9	1989	However, when the magnitude of phosphaturic response is expressed as net increase during 2 h after PTH, it tends to be enhanced after vitamin D therapy in patients with PsH compared to the response before therapy.	Vitamin D	134-143	parathyroid hormone	Homo sapiens	99-102
2911322-5	1989	We conclude that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in response to parathyroid hormone, and that in osteoporosis the age-appropriate parathyroid hormone response to the same hypocalcemic signal is diminished.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	47-66
2553333-0	1989	Proteoglycan synthesis in vitamin D-deficient cartilage: recovery from vitamin D deficiency.	Vitamin D	26-35	versican	Gallus gallus	0-12
2644746-1	1989	The parathyroid gland possesses receptors for 1,25-dihydroxyvitamin D3, the active metabolite of the vitamin D system, and in vitro experiments have shown that 1,25-dihydroxyvitamin D3 can inhibit the secretion of PTH.	Vitamin D	60-69	parathyroid hormone	Homo sapiens	214-217
2784002-0	1989	Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression.	Vitamin D	56-65	bone gamma-carboxyglutamate protein	Rattus norvegicus	21-32
2909247-4	1989	In this report, we evaluated the binding of the 105 kDa protein to other radioiodinated calcium-binding proteins including the vitamin D-dependent intestinal calcium-binding protein.	Vitamin D	127-136	calcium-binding protein	Gallus gallus	88-111
2643969-0	1989	Reduction of blood pressure during long-term treatment with active vitamin D (alphacalcidol) is dependent on plasma renin activity and calcium status.	Vitamin D	67-76	renin	Homo sapiens	116-121
2643969-7	1989	This study supports the idea of a relationship between calcium metabolism and the renin-aldosterone system in essential hypertension and describes a beneficial effect of vitamin D supplementation on blood pressure in low-renin hypertension.	Vitamin D	170-179	renin	Homo sapiens	221-226
2553333-0	1989	Proteoglycan synthesis in vitamin D-deficient cartilage: recovery from vitamin D deficiency.	Vitamin D	71-80	versican	Gallus gallus	0-12
2605954-6	1989	First, contained within the 600 nucleotides immediately upstream from the transcription initiation site are sequences which support Vitamin D dependent transcription of the rat osteocalcin gene.	Vitamin D	132-141	bone gamma-carboxyglutamate protein	Rattus norvegicus	177-188
2612164-1	1989	The osteoblast phenotype is characterized by its ability to (a) synthesize a well defined mineralized collagenous matrix, (b) regulate the remodeling process by synthesizing local hormones (PGE2) and specific molecules (osteocalcin) and enzymes (alkaline phosphatase and collagenase), (c) respond to a variety of hormones (PTH, PGs, vitamin-D metabolites, steroids and growth factors), (d) respond to mechanical stimulation.	Vitamin D	333-342	bone gamma-carboxyglutamate protein	Homo sapiens	220-231
2691326-2	1989	Additionally, there is a considerable body of animal data suggesting that vitamin D has a significant impact on insulin secretion.	Vitamin D	74-83	insulin	Homo sapiens	112-119
2647606-0	1989	Effect of different insulin administration modalities on vitamin D metabolism of insulin-dependent diabetic patients.	Vitamin D	57-66	insulin	Homo sapiens	20-27
2668614-0	1989	[Effect of insulin on the liver metabolism of lipids and vitamin D in the diabetic patient: clinical implications].	Vitamin D	57-66	insulin	Homo sapiens	11-18
2724638-0	1989	Studies on parathyroid hormone, vitamin D and pseudohypoparathyroidism: an example of trail from basic science to clinical practice.	Vitamin D	32-41	TNF superfamily member 10	Homo sapiens	86-91
2615719-2	1989	In a recent survey of 306 patients with primary hyperparathyroidism (PHPT), we hypothesized that the far higher degree of parathyroid hormone (PTH) hypersecretion in PHPT with osteitis fibrosa cystica than in PHPT without overt bone disease might be due to the absence of suppression of hormonal hypersecretion by the low-to-normal circulating 1,25(OH)2D reflecting a relative vitamin D deficiency.	Vitamin D	377-386	parathyroid hormone	Homo sapiens	122-141
3063116-7	1988	The PTH-vitamin D axis as modulated by the serum ionized calcium level controls adaptation to alterations in dietary calcium and sodium intake and to changes in skeletal turnover based on the level of physical activity.	Vitamin D	8-17	parathyroid hormone	Homo sapiens	4-7
2848683-4	1988	Renal membranes of vitamin D-deficient rats with secondary hyperparathyroidism had a reduced PLP-stimulated as well as PTH-stimulated adenylate cyclase response.	Vitamin D	19-28	parathyroid hormone	Rattus norvegicus	119-122
3145795-1	1988	X-linked hypophosphatemic (Hyp) mice are a model for human X-linked (familial) hypophosphatemia (vitamin D-resistant rickets).	Vitamin D	97-106	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	27-30
2467438-0	1988	[Structural properties and lipid-binding characteristics of plasma fibrinogen and gamma-globulins in vitamin D-deficient rickets].	Vitamin D	101-110	fibrinogen beta chain	Homo sapiens	67-77
3049577-2	1988	Studies of vitamin D-dependent 28-kilodalton calcium binding protein (calbindin D28) have been hindered by difficulties in purifying large amounts of the protein.	Vitamin D	11-20	calbindin 1	Rattus norvegicus	70-83
2848397-2	1988	We showed previously that obese white subjects have low serum vitamin D and 25-hydroxyvitamin D (25-OHD) with increased serum-immunoreactive parathyroid hormone (PTH) and 1,25-(OH)2D, low urinary calcium, and increased urinary cyclic adenosine 3",5"-monophosphate (cyclic AMP) compared with nonobese white individuals.	Vitamin D	62-71	parathyroid hormone	Homo sapiens	141-160
2460748-3	1988	Administration of 1,25-(OH)2D3 for 7 days (25 ng/day) to vitamin D-deficient rats resulted in a marked increase in renal calbindin-DmRNA, renal calbindin, and serum calcium.	Vitamin D	57-66	calbindin 1	Rattus norvegicus	121-130
2460748-3	1988	Administration of 1,25-(OH)2D3 for 7 days (25 ng/day) to vitamin D-deficient rats resulted in a marked increase in renal calbindin-DmRNA, renal calbindin, and serum calcium.	Vitamin D	57-66	calbindin 1	Rattus norvegicus	144-153
2460748-6	1988	In dietary alteration studies in vitamin D-replete rats, renal calbindin protein and mRNA increased 2.5-fold in rats fed diets low in phosphate providing evidence that in the rat the nutritional induction of calbindin is accompanied by a corresponding alteration in the concentration of its specific mRNA.	Vitamin D	33-42	calbindin 1	Rattus norvegicus	208-217
3141012-0	1988	Vitamin D-dependent active calcium transport: the role of CaBP.	Vitamin D	0-9	S100 calcium binding protein G	Homo sapiens	58-62
3071395-0	1988	Effect of long-term and short-term diabetes on the parathyroid hormone sensitive rat renal adenylate cyclase: correlation with vitamin D metabolism.	Vitamin D	127-136	parathyroid hormone	Rattus norvegicus	51-70
3414685-0	1988	Primary cultures of renal epithelial cells from X-linked hypophosphatemic (Hyp) mice express defects in phosphate transport and vitamin D metabolism.	Vitamin D	128-137	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	75-78
3414685-4	1988	In vitro studies in the Hyp mouse have shown decreased Na+-dependent phosphate transport at the brush border membrane and abnormal mitochondrial vitamin D metabolism.	Vitamin D	145-154	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	24-27
3141012-4	1988	However, intracellular calcium movement inside the mucosal cell can match the experimental Vm of transcellular transport only in the presence of the vitamin D-dependent calcium-binding protein (CaBP, Mr = 8.8kDa).	Vitamin D	149-158	S100 calcium binding protein G	Homo sapiens	194-198
3141012-6	1988	Thus, the major action of vitamin D on cellular calcium transport is via its hormonal product, CaBP, which amplifies intracellular calcium movement by raising total and free calcium levels in the transporting cell.	Vitamin D	26-35	S100 calcium binding protein G	Homo sapiens	95-99
2460662-2	1988	To determine whether vitamin D-dependent 28-kilodalton-calcium binding protein (28kDa-CaBP)and Ca++-Mg++ ATPase are present in the same cells of the human kidney, kidney tissue was examined for immunoreactivity with antibodies directed against these proteins.	Vitamin D	21-30	S100 calcium binding protein G	Homo sapiens	86-90
2846207-0	1988	Chromatography of serum on Sep-pak C18 corrects falsely elevated vitamin D metabolite levels measured by protein binding assay.	Vitamin D	65-74	Bardet-Biedl syndrome 9	Homo sapiens	35-38
3384820-0	1988	Analysis of rat vitamin D-dependent calbindin-D28k gene expression.	Vitamin D	16-25	calbindin 1	Rattus norvegicus	36-45
2846207-7	1988	These findings indicate that chromatography of serum on Sep-pak C18 cartridges corrects falsely elevated vitamin D metabolite levels measured by protein binding assay.	Vitamin D	105-114	Bardet-Biedl syndrome 9	Homo sapiens	64-67
3049099-8	1988	In rats, the Ca2+ antagonist verapamil not only prevented arterial calcinosis due to overdoses of vitamin D and dihydrotachysterol but also counteracted age-dependent Ca2+ accumulation.	Vitamin D	98-107	carbonic anhydrase 2	Rattus norvegicus	13-16
3341776-1	1988	Calbindin-D (vitamin D-induced calcium-binding protein; CaBP) is known to be present in blood at concentrations which vary directly with levels in the intestinal mucosa.	Vitamin D	13-22	S100 calcium binding protein G	Homo sapiens	56-60
3213628-6	1988	To assess the effect of oxidation on the ability of PTH to inhibit the production of the 24,25-dihydroxyvitamin D3 (24,25(OH)2D3), the infusion protocol was performed in vitamin D-deficient rats repleted with 1,25(OH)2D3 by injection.	Vitamin D	104-113	parathyroid hormone	Rattus norvegicus	52-55
3373390-9	1988	Taken as a whole, these data suggest that the vitamin D-sufficient term infant fed human milk, cow milk-based formula, or the soy-based formula studied can regulate mineral metabolism within acceptable physiologic limits to attain similar levels of serum minerals and bone mineral content.	Vitamin D	46-55	Weaning weight-maternal milk	Bos taurus	89-93
2834176-0	1988	Parathyroid hormone desensitization in renal membranes of vitamin D-deficient rats is associated with a postreceptor defect.	Vitamin D	58-67	parathyroid hormone	Rattus norvegicus	0-19
2834176-1	1988	We examined the characteristics of PTH resistance in vitamin D-deficient rats employing renal membranes in vitro.	Vitamin D	53-62	parathyroid hormone	Rattus norvegicus	35-38
2834176-8	1988	The results suggest that a major contribution to PTH resistance in vitamin D-deficient animals is a postreceptor defect at the level of the G proteins and that this defect is manifest only in tissue expressing the PTH receptor.	Vitamin D	67-76	parathyroid hormone	Rattus norvegicus	49-52
2834176-8	1988	The results suggest that a major contribution to PTH resistance in vitamin D-deficient animals is a postreceptor defect at the level of the G proteins and that this defect is manifest only in tissue expressing the PTH receptor.	Vitamin D	67-76	parathyroid hormone	Rattus norvegicus	214-217
3374126-6	1988	DBP counteracted the inhibitory effect of all analogs and the degree of counteraction was directly proportional to the binding affinity between DBP and the vitamin D analog.	Vitamin D	156-165	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
3374126-6	1988	DBP counteracted the inhibitory effect of all analogs and the degree of counteraction was directly proportional to the binding affinity between DBP and the vitamin D analog.	Vitamin D	156-165	D-box binding PAR bZIP transcription factor	Homo sapiens	144-147
3348387-3	1988	In the present work, the role of PTH was assessed by studying the influence of 1-hydroxypentane-1,1-bisphosphonate (HPeBP) on vitamin D and Ca metabolism in both intact and thyroparathyroidectomized (TPTX) rats.	Vitamin D	126-135	parathyroid hormone	Rattus norvegicus	33-36
3341776-7	1988	It is proposed that vitamin D-dependent enhanced transcellular calcium transport constitutes a stimulus for the increased release of intestinal CaBP into the circulation.	Vitamin D	20-29	S100 calcium binding protein G	Homo sapiens	144-148
3260859-9	1988	It appears that the active form of vitamin D directly increases the secretion of BGP in existing osteoblasts and PTH mainly affects serum BGP to stimulate the bone remodeling cycles with its long term effect.	Vitamin D	35-44	bone gamma-carboxyglutamate protein	Homo sapiens	81-84
2828005-8	1988	Hypophosphatemia, therefore, appears to play a role in the vitamin D resistance in Hyp mice.	Vitamin D	59-68	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	0-3
2831435-7	1988	This was a much shorter half-life than that exhibited by other vitamin D metabolites and was expected because of the poor affinity 10-oxo-D3 has for the plasma vitamin D binding protein.	Vitamin D	63-72	iodothyronine deiodinase 3	Homo sapiens	138-140
2850724-0	1988	Certain vitamin D metabolites potentiate the expression of parathyroid hormone bioactivity.	Vitamin D	8-17	parathyroid hormone	Rattus norvegicus	59-78
3592447-1	1987	Studies of the parathyroid hormone-vitamin D axis.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	15-34
3060161-11	1988	Through the vitamin D-PTH axis the endocrine system regulates the phosphate balance by influencing the kidney, gut, and bone.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	22-25
3257676-1	1988	Vitamin D compounds suppress the production of interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin in a dose-dependent manner.	Vitamin D	0-9	interleukin 2	Homo sapiens	47-60
3257676-1	1988	Vitamin D compounds suppress the production of interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin in a dose-dependent manner.	Vitamin D	0-9	interleukin 2	Homo sapiens	62-66
3265105-1	1988	Osteocalcin synthesis is dependent on the influence of the renal vitamin D metabolite, 1,25(OH)2D3.	Vitamin D	65-74	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
3170090-2	1988	After preparative chromatography with Silica Sep Pak and C18-Sep Pak cartridges the dihydroxylated vitamin D metabolite was quantified in a specific protein binding assay.	Vitamin D	99-108	Bardet-Biedl syndrome 9	Homo sapiens	57-60
3129486-1	1988	Several reports claim that thyroid hormones and growth hormone participate in the regulation of vitamin D synthesis.	Vitamin D	96-105	growth hormone 1	Homo sapiens	48-62
3388819-0	1988	The mutants of the vitamin-D-binding protein: more than 120 variants of the GC/DBP system.	Vitamin D	19-28	D-box binding PAR bZIP transcription factor	Homo sapiens	79-82
3322503-1	1987	The PAP immunohistochemical method was used to carry out a light- and electronmicroscopic study of the distribution of the vitamin D-dependent calcium-binding protein (CaBP-28k, calbindin, cholecalcin) in the vestibule of the young cat.	Vitamin D	123-132	centrin 1	Homo sapiens	143-166
3040311-1	1987	X-linked hypophosphatemic (Hyp) mice are a model of human sex-linked vitamin D-resistant rickets.	Vitamin D	69-78	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	27-30
3039857-2	1987	The analogue inhibited PTH-stimulated urinary excretion of phosphate and adenosine 3",5"-cyclic monophosphate in vitamin D-deficient thyroparathyroidectomized rats in a dose-dependent manner.	Vitamin D	113-122	parathyroid hormone	Rattus norvegicus	23-26
3305814-2	1987	One, a saturable transcellular process is regulated by vitamin D via its molecular product, the calcium-binding protein (CaBP, MW = 8800).	Vitamin D	55-64	centrin 1	Homo sapiens	96-119
3305814-2	1987	One, a saturable transcellular process is regulated by vitamin D via its molecular product, the calcium-binding protein (CaBP, MW = 8800).	Vitamin D	55-64	centrin 1	Homo sapiens	121-125
3675739-5	1987	The different electrophoretic mobilities between Old and New World Monkeys show that: 1) the Cercopithecoidea are presenting the largest genetic heterogeneity; 2) the DBP among the Galago corresponds to the lowest isoelectric points observed among Primates; 3) during the evolution from nonhuman Primates to Man, the DBP is able to keep its affinity for vitamin D derivatives despite the occurrence of significant molecular modifications; 4) among Anthropoidea, the electrophoretic patterns of DBP are very close to the human Gc1 proteins.	Vitamin D	354-363	D-box binding PAR bZIP transcription factor	Homo sapiens	167-170
3494594-1	1987	Osteocalcin, the vitamin K-dependent protein in bone containing gamma-carboxyglutamic acid, has been found to be significantly decreased in the osteomalacic bone of chicks made vitamin D deficient for 6 weeks.	Vitamin D	177-186	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-11
3665123-0	1987	Remission of hypoparathyroidism during lactation: evidence for a physiological role for prolactin in the regulation of vitamin D metabolism.	Vitamin D	119-128	prolactin	Homo sapiens	88-97
3494594-5	1987	In the vitamin D-deficient animals, osteomalacia was evident histologically by 7 weeks, at which time serum 1,25-(OH)2D3 was not detectable, bone osteocalcin was decreased by 50%, and serum osteocalcin was decreased by 20%.	Vitamin D	7-16	bone gamma-carboxyglutamate protein	Rattus norvegicus	146-157
3494594-5	1987	In the vitamin D-deficient animals, osteomalacia was evident histologically by 7 weeks, at which time serum 1,25-(OH)2D3 was not detectable, bone osteocalcin was decreased by 50%, and serum osteocalcin was decreased by 20%.	Vitamin D	7-16	bone gamma-carboxyglutamate protein	Rattus norvegicus	190-201
3494594-7	1987	These data are consistent with the conclusion that the metabolism of osteocalcin is affected by serum 1,25-(OH)2D3 and that the diminished level of osteocalcin in the bone of vitamin D-deficient animals is the result of a direct action of the metabolites and is not secondary to a decrease in the mineralization of bone tissue.	Vitamin D	175-184	bone gamma-carboxyglutamate protein	Rattus norvegicus	148-159
3552957-1	1987	The metabolically active form of vitamin D, 1,25-(OH)2D3, is involved in the regulation of insulin level.	Vitamin D	33-42	insulin	Homo sapiens	91-98
3552627-1	1987	Vitamin D binding protein (DBP), a Mr 56,000-58,000 alpha 2-glycoprotein, is the major serum protein involved in the transport of vitamin D sterols.	Vitamin D	130-139	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
3494037-7	1987	These results indicate that PTH concentrations are frequently elevated in PBC patients despite adequate vitamin D supplementation and normal or even supranormal plasma calcium concentrations.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	28-31
3037155-0	1987	The cAMP system in vasopressin-sensitive nephron segments of the vitamin D-treated rat.	Vitamin D	65-74	arginine vasopressin	Rattus norvegicus	19-30
2437519-11	1987	9K CaBP mRNA was present in classical vitamin D target tissues such as duodenum and placenta; high levels of 9K CaBP mRNA also were found in thymus and lung.	Vitamin D	38-47	S100 calcium binding protein G	Homo sapiens	3-7
3470294-9	1987	The FN response was specific to 1,25-(OH)2D3 when compared with other vitamin D metabolites.	Vitamin D	70-79	fibronectin 1	Homo sapiens	4-6
3771798-0	1986	Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat.	Vitamin D	14-23	parathyroid hormone	Rattus norvegicus	39-58
3828767-1	1986	The 28,000-Da vitamin D-dependent calcium-binding protein, CaBP, which is induced by one hormonally active form of vitamin D3, 1,25-dihydroxyvitamin D3, was localized by immunocytochemistry in the human brainstem, cerebellum and cervical segment of the spinal cord.	Vitamin D	14-23	S100 calcium binding protein G	Homo sapiens	59-63
3509783-2	1986	This study was undertaken to assess the possible direct, acute effects of vitamin D metabolites on PTH secretion in vitro.	Vitamin D	74-83	parathyroid hormone	Rattus norvegicus	99-102
3509783-9	1986	Parathyroid glands from -D rats incubated with 0.75 mM Ca secreted more PTH than glands of similar weight from rats given 25 micrograms vitamin D3 3 days earlier, suggesting that vitamin D or a metabolite of vitamin D may modulate the sensitivity of the parathyroid gland to medium Ca.	Vitamin D	179-188	parathyroid hormone	Rattus norvegicus	72-75
3105848-1	1987	Vitamin D-deficient, second generation, rachitic rats showed significant decrease in bone Gla protein (BGP) levels in circulation and in the skeleton.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	85-101
3105848-1	1987	Vitamin D-deficient, second generation, rachitic rats showed significant decrease in bone Gla protein (BGP) levels in circulation and in the skeleton.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	103-106
3829120-1	1987	The molecular cloning of a cDNA fragment synthesised from rat duodenal mRNA coding for cholecalcin (calbindin), a 9000 Mr vitamin D-induced calcium-binding protein (CaBP), has been previously described.	Vitamin D	122-131	calbindin 1	Rattus norvegicus	100-109
3550213-1	1987	The kidney distribution of 28 kDa vitamin D-induced calcium binding protein (CaBP) was studied in 15 fetuses (11 to 33 weeks old), six children and adults (12 days to 32 years old) by immunocytochemistry using a specific antibody to rat renal 28 kDa CaBP.	Vitamin D	34-43	centrin 1	Homo sapiens	52-75
3550213-1	1987	The kidney distribution of 28 kDa vitamin D-induced calcium binding protein (CaBP) was studied in 15 fetuses (11 to 33 weeks old), six children and adults (12 days to 32 years old) by immunocytochemistry using a specific antibody to rat renal 28 kDa CaBP.	Vitamin D	34-43	centrin 1	Homo sapiens	77-81
3027149-6	1986	Concentrations of vitamin D metabolites in the milk of the treated cows did not differ significantly from those of controls.	Vitamin D	18-27	Weaning weight-maternal milk	Bos taurus	47-51
3755724-5	1986	It has an open reading frame of 270 nucleotides, which has a 55% homology with the coding sequence of the beta-subunit of the S-100 protein, a calcium-binding protein that belongs (like calmodulin and the vitamin D-dependent intestinal calcium-binding protein) to the family of calcium-modulated proteins and is found in abundance in several human tumors, including melanoma.	Vitamin D	205-214	S100 calcium binding protein B	Homo sapiens	126-131
3755578-0	1986	Analysis of the mRNA coding for the chick vitamin D-induced calbindin and its regulation by 1,25-dihydroxyvitamin D3.	Vitamin D	42-51	calcium-binding protein	Gallus gallus	60-69
3492836-3	1986	The aim of this study was to examine the rate of bone formation measured by osteocalcin in patients (pts) with rheumatoid arthritis (RA) (n = 58) and osteoarthrosis (OA) (n = 14) and its dependence on various parameters of calcium and phosphate metabolism, especially vitamin D metabolites.	Vitamin D	268-277	bone gamma-carboxyglutamate protein	Homo sapiens	76-87
3755578-1	1986	We have used specific cloned cDNA probes generated from the mRNA coding for the vitamin D-induced 28,000-Da chick intestinal calcium binding protein (calbindin) to study the hormonal regulation of the expression of this mRNA by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	Vitamin D	80-89	calcium-binding protein	Gallus gallus	125-148
3755578-1	1986	We have used specific cloned cDNA probes generated from the mRNA coding for the vitamin D-induced 28,000-Da chick intestinal calcium binding protein (calbindin) to study the hormonal regulation of the expression of this mRNA by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	Vitamin D	80-89	calcium-binding protein	Gallus gallus	150-159
3755578-8	1986	Examination of other chick tissues (both vitamin D-deficient and -replete) reveals a close association between mRNA expression and previously observed calbindin expression.	Vitamin D	41-50	calcium-binding protein	Gallus gallus	151-160
3754871-10	1986	These studies demonstrate that yolk sac immunoreactive CaBP is synthesized in yolk sac and has an apparent molecular size and calcium-binding properties characteristic of mammalian vitamin D-dependent calcium-binding proteins.	Vitamin D	181-190	S100 calcium binding protein G	Homo sapiens	55-59
3489605-1	1986	The aim of this investigation was to study the bone metabolism in early infancy by establishing the relationship between serum osteocalcin levels and the hormonal vitamin D status of exclusively breast-fed infants during their first month of life.	Vitamin D	163-172	bone gamma-carboxyglutamate protein	Homo sapiens	127-138
3489605-5	1986	The administration of vitamin D to breast-fed infants should in fact have an effect on bone activity as reflected by the increase in osteocalcin levels.	Vitamin D	22-31	bone gamma-carboxyglutamate protein	Homo sapiens	133-144
3459646-1	1986	The vitamin D-dependent calcium-binding protein (CaBP), cholecalcin or calbindin, is one of the best documented molecular expressions of 1,25-dihydroxyvitamin D, the hormonal metabolite of vitamin D.	Vitamin D	4-13	calbindin 1	Rattus norvegicus	71-80
3004922-1	1986	The in vivo effect of PTH on renal 24-hydroxylase activity of 25-hydroxyvitamin D3 (25OHD3) was examined in vitamin D-deficient thyroparathyroidectomized rats by a recently developed sensitive in vitro assay of 25OHD3-hydroxylases using rat kidney homogenates and by an in vivo assay measuring the accumulation of tritiated metabolites in plasma 5 h after injection of 25OH[3H]D3.	Vitamin D	72-81	parathyroid hormone	Rattus norvegicus	22-25
3486118-7	1986	In vitamin D-sufficient animals, parathyroidectomy led to a 50% reduction in BMAR, which could be restored by treatment with PTH alone but not with 24,25-(OH)2D3.	Vitamin D	3-12	parathyroid hormone	Rattus norvegicus	125-128
3508722-0	1986	Circulating parathyroid hormone concentrations in normal and vitamin D-deprived rat pups determined with an N-terminal-specific radioimmunoassay.	Vitamin D	61-70	parathyroid hormone	Rattus norvegicus	12-31
3015628-5	1986	Osteocalcin was elevated in primary hypoparathyroidism, low in untreated hypoparathyroidism but normal in hypoparathyroidism (including pseudohypoparathyroidism) during vitamin D treatment.	Vitamin D	169-178	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
3015628-9	1986	It is concluded that the measurement of serum osteocalcin seems to be a reliable index of bone formation provided that the vitamin D status and renal function are normal.	Vitamin D	123-132	bone gamma-carboxyglutamate protein	Homo sapiens	46-57
3503535-1	1986	As compared to nonobese white men and women, age-matched nonobese black subjects and obese white individuals show alterations in the vitamin D-endocrine system that are characterized by increases in mean serum immunoreactive parathyroid hormone (PTH), serum 1,25-dihydroxyvitamin D [1,25-(OH)2D], and urinary cyclic adenosine 3,5-monophosphate (cAMP) and by decreases in mean serum 25-hydroxyvitamin D (25 OHD) and in urinary calcium.	Vitamin D	133-142	parathyroid hormone	Homo sapiens	225-244
3503535-1	1986	As compared to nonobese white men and women, age-matched nonobese black subjects and obese white individuals show alterations in the vitamin D-endocrine system that are characterized by increases in mean serum immunoreactive parathyroid hormone (PTH), serum 1,25-dihydroxyvitamin D [1,25-(OH)2D], and urinary cyclic adenosine 3,5-monophosphate (cAMP) and by decreases in mean serum 25-hydroxyvitamin D (25 OHD) and in urinary calcium.	Vitamin D	133-142	parathyroid hormone	Homo sapiens	246-249
3003405-10	1986	These data suggest tumor induction of parathyroid hormone-like humoral modulation of calcium, phosphate and vitamin D metabolism in vivo associated with a parathyroid hormone-like prostate carcinoma product.	Vitamin D	108-117	parathyroid hormone	Homo sapiens	38-57
3516771-0	1986	Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man.	Vitamin D	11-20	insulin	Homo sapiens	49-56
3958856-1	1986	Vitamin D binding protein (DBP) is the major carrier for vitamin D and its metabolites in serum.	Vitamin D	57-66	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
3958856-10	1986	We speculate that serum DBP fluctuations are a response to varying vitamin D needs: increased serum DBP occurs in low vitamin D status to maximize uptake of vitamin D from skin.	Vitamin D	67-76	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
3958856-10	1986	We speculate that serum DBP fluctuations are a response to varying vitamin D needs: increased serum DBP occurs in low vitamin D status to maximize uptake of vitamin D from skin.	Vitamin D	67-76	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
3958856-10	1986	We speculate that serum DBP fluctuations are a response to varying vitamin D needs: increased serum DBP occurs in low vitamin D status to maximize uptake of vitamin D from skin.	Vitamin D	118-127	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
3958856-10	1986	We speculate that serum DBP fluctuations are a response to varying vitamin D needs: increased serum DBP occurs in low vitamin D status to maximize uptake of vitamin D from skin.	Vitamin D	118-127	D-box binding PAR bZIP transcription factor	Homo sapiens	100-103
3753677-7	1986	When 1,25-dihydroxyvitamin D was administered to vitamin D-deficient chicks, the binding of CaM to the 102K CaM-binding protein appeared to increase more rapidly in BBMV from cells near the tip of the villus than in cells from more basal regions, comparable to our previously reported data for 1,25-dihydroxyvitamin D-stimulated calcium accumulation by similarly prepared BBMV.	Vitamin D	19-28	calmodulin 1	Homo sapiens	92-95
3753677-7	1986	When 1,25-dihydroxyvitamin D was administered to vitamin D-deficient chicks, the binding of CaM to the 102K CaM-binding protein appeared to increase more rapidly in BBMV from cells near the tip of the villus than in cells from more basal regions, comparable to our previously reported data for 1,25-dihydroxyvitamin D-stimulated calcium accumulation by similarly prepared BBMV.	Vitamin D	19-28	calmodulin 1	Homo sapiens	108-111
3551545-0	1986	Effects of different insulin administration modalities on vitamin D metabolism of insulin-dependent diabetic patients.	Vitamin D	58-67	insulin	Homo sapiens	21-28
6335331-4	1984	Under the combination therapy with KA and vitamin D despite the reduction of the phosphate binders another significant decrease of the PTH and the anorganic phosphate was observed.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	135-138
2869867-5	1986	In the vitamin D-fed chicks, kidney CaBP varied independently of the circulating or organ level of 1,25(OH)2D3 (P greater than 0.05), but was lower in the vitamin D-deficient than in the vitamin D-fed birds.	Vitamin D	7-16	calcium-binding protein	Gallus gallus	36-40
2869867-5	1986	In the vitamin D-fed chicks, kidney CaBP varied independently of the circulating or organ level of 1,25(OH)2D3 (P greater than 0.05), but was lower in the vitamin D-deficient than in the vitamin D-fed birds.	Vitamin D	155-164	calcium-binding protein	Gallus gallus	36-40
2869867-5	1986	In the vitamin D-fed chicks, kidney CaBP varied independently of the circulating or organ level of 1,25(OH)2D3 (P greater than 0.05), but was lower in the vitamin D-deficient than in the vitamin D-fed birds.	Vitamin D	155-164	calcium-binding protein	Gallus gallus	36-40
2869867-7	1986	The regression equations were CaBP = Cap/(85.57-4.00 Cap) (R = 0.845) and CaBP = 0.0558 + 0.0404 Cap (R = 0.749), for vitamin D-treated and vitamin D-deficient chicks, respectively.	Vitamin D	118-127	calcium-binding protein	Gallus gallus	30-34
2869867-7	1986	The regression equations were CaBP = Cap/(85.57-4.00 Cap) (R = 0.845) and CaBP = 0.0558 + 0.0404 Cap (R = 0.749), for vitamin D-treated and vitamin D-deficient chicks, respectively.	Vitamin D	118-127	calcium-binding protein	Gallus gallus	74-78
3754230-5	1986	In vitamin D-deficient epileptic and geriatric patients, the 2- and 3-h insulin levels after glucose ingestion were increased when compared with control values, and glucagon secretion was not suppressed by glucose.	Vitamin D	3-12	insulin	Homo sapiens	72-79
3485617-3	1986	Our data suggest that the higher serum levels of vitamin D metabolites during the summer suppress PTH secretion.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	98-101
3485617-4	1986	During the winter, the reduction of serum levels of vitamin D metabolites due to decreased endogenous production was accompanied by an increase in serum PTH levels.	Vitamin D	52-61	parathyroid hormone	Homo sapiens	153-156
3873510-0	1985	Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	31-42
2988219-0	1985	[Vitamin D sterol in human milk, cow"s milk and baby food].	Vitamin D	1-10	Weaning weight-maternal milk	Bos taurus	27-31
2988219-1	1985	A review is given of the results of vitamin D determinations in human and cow"s milk using physico-chemical methods.	Vitamin D	36-45	Weaning weight-maternal milk	Bos taurus	80-84
2988219-5	1985	A comparison of the concentration of these vitamin D metabolites in human milk and infant formulas based upon cow"s milk suggests that the higher anti-rachitic activity of human milk is connected with its higher concentration of 25-hydroxy-vitamin D.	Vitamin D	43-52	Weaning weight-maternal milk	Bos taurus	74-78
2988219-5	1985	A comparison of the concentration of these vitamin D metabolites in human milk and infant formulas based upon cow"s milk suggests that the higher anti-rachitic activity of human milk is connected with its higher concentration of 25-hydroxy-vitamin D.	Vitamin D	43-52	Weaning weight-maternal milk	Bos taurus	116-120
2988219-5	1985	A comparison of the concentration of these vitamin D metabolites in human milk and infant formulas based upon cow"s milk suggests that the higher anti-rachitic activity of human milk is connected with its higher concentration of 25-hydroxy-vitamin D.	Vitamin D	43-52	Weaning weight-maternal milk	Bos taurus	116-120
6149694-1	1984	Previous studies have suggested that prolactin (PRL) may affect calcium (Ca) homeostasis by an action on vitamin D metabolism.	Vitamin D	105-114	prolactin	Bos taurus	37-46
6149694-1	1984	Previous studies have suggested that prolactin (PRL) may affect calcium (Ca) homeostasis by an action on vitamin D metabolism.	Vitamin D	105-114	prolactin	Bos taurus	48-51
3615650-1	1987	Hyp mice are a model for X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets.	Vitamin D	76-85	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	0-3
3840736-6	1985	Calcium infusions into hypocalcemic, vitamin D-deficient rats caused a fall in serum bioactive PTH concentrations to a mean of 13% of control values within 10 min.	Vitamin D	37-46	parathyroid hormone	Rattus norvegicus	95-98
2990344-0	1985	Changes of intestinal alkaline phosphatase produced by cholecalciferol or 1,25-dihydroxyvitamin D3 in vitamin D-deficient chicks.	Vitamin D	88-97	alkaline phosphatase, intestinal	Homo sapiens	11-42
2985632-1	1985	The ability of the hormonally active vitamin D metabolite, 1 alpha, 25-dihydroxyvitamin D3, to affect cell growth, morphology and fibronectin production has been examined using the MG-63 human osteosarcoma cell line.	Vitamin D	37-46	fibronectin 1	Homo sapiens	130-141
2988477-5	1985	Finally, discovery of the gene of CaBP 9K in man opens the prospect of studies which will improve the understanding of the mechanism of action of vitamin D.	Vitamin D	146-155	S100 calcium binding protein G	Homo sapiens	34-41
3919968-1	1985	A simple method for the quantification of the vitamin D binding capacity (concentration of vitamin D binding protein, DBP) in serum is described.	Vitamin D	46-55	D-box binding PAR bZIP transcription factor	Homo sapiens	118-121
2409998-4	1985	Serum DBP correlated positively with serum total protein, albumin, alpha 2-globulin, and the vitamin D metabolite levels in the patients.	Vitamin D	93-102	D-box binding PAR bZIP transcription factor	Homo sapiens	6-9
2982764-2	1985	The diagnostic value of measuring serum vitamin D metabolites is demonstrated in the present study in which two patients with vitamin D-dependent rickets (VDDR) Types I and II are reported.	Vitamin D	40-49	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	155-159
2982764-2	1985	The diagnostic value of measuring serum vitamin D metabolites is demonstrated in the present study in which two patients with vitamin D-dependent rickets (VDDR) Types I and II are reported.	Vitamin D	126-135	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	155-159
6489266-0	1984	Membrane-associated vitamin D-induced calcium-binding protein (CaBP): quantification by a radioimmunoassay and evidence for a specific CaBP in purified intestinal brush borders.	Vitamin D	20-29	centrin 1	Homo sapiens	38-61
6489266-0	1984	Membrane-associated vitamin D-induced calcium-binding protein (CaBP): quantification by a radioimmunoassay and evidence for a specific CaBP in purified intestinal brush borders.	Vitamin D	20-29	centrin 1	Homo sapiens	63-67
6489266-0	1984	Membrane-associated vitamin D-induced calcium-binding protein (CaBP): quantification by a radioimmunoassay and evidence for a specific CaBP in purified intestinal brush borders.	Vitamin D	20-29	centrin 1	Homo sapiens	135-139
6489266-1	1984	The vitamin D-induced intestinal calcium-binding protein (CaBP) was quantitated in membranous components of the intestinal mucosa by a specific and sensitive RIA.	Vitamin D	4-13	centrin 1	Homo sapiens	33-56
6489266-1	1984	The vitamin D-induced intestinal calcium-binding protein (CaBP) was quantitated in membranous components of the intestinal mucosa by a specific and sensitive RIA.	Vitamin D	4-13	centrin 1	Homo sapiens	58-62
6087742-0	1984	Pancreatic vitamin D-dependent calcium binding protein: biochemical properties and response to vitamin D.	Vitamin D	11-20	calcium-binding protein	Gallus gallus	31-54
6611345-2	1984	These elevated PTH concentrations, though not as high as those in osteomalacic patients with hypocalcemia, often persisted despite treatment with vitamin D, normalization of 25-hydroxyvitamin D, and an increase in calcium concentrations.	Vitamin D	146-155	parathyroid hormone	Homo sapiens	15-18
6611345-5	1984	Persistent elevation of PTH despite normalization of 25-hydroxyvitamin D also points to autonomous PTH hypersecretion, which may result in osteolysis in the long term, and raises the question of the need for vitamin D supplementation in vegetarians with low dietary intake of vitamin D.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	99-102
6087742-0	1984	Pancreatic vitamin D-dependent calcium binding protein: biochemical properties and response to vitamin D.	Vitamin D	95-104	calcium-binding protein	Gallus gallus	31-54
6087742-1	1984	The biochemical properties of a chick pancreatic calcium binding protein (CaBP) and its response to vitamin D status and dietary calcium and phosphorus levels were studied and compared with the known vitamin D-dependent CaBPs present in the chick intestine and kidney.	Vitamin D	100-109	calcium-binding protein	Gallus gallus	49-72
6087742-1	1984	The biochemical properties of a chick pancreatic calcium binding protein (CaBP) and its response to vitamin D status and dietary calcium and phosphorus levels were studied and compared with the known vitamin D-dependent CaBPs present in the chick intestine and kidney.	Vitamin D	100-109	calcium-binding protein	Gallus gallus	74-78
6087742-3	1984	Pancreatic levels of CaBP respond to changes in vitamin D status and dietary Ca and P level in a fashion similar to the intestinal CaBP.	Vitamin D	48-57	calcium-binding protein	Gallus gallus	21-25
6087742-7	1984	Collectively, these results suggest that the chick pancreatic vitamin D-dependent CaBP is a homologous protein to the intestinal CaBP, both with regards to its relative cellular concentration as well as in its response to changing dietary levels of Ca and P.	Vitamin D	62-71	calcium-binding protein	Gallus gallus	82-86
6087742-7	1984	Collectively, these results suggest that the chick pancreatic vitamin D-dependent CaBP is a homologous protein to the intestinal CaBP, both with regards to its relative cellular concentration as well as in its response to changing dietary levels of Ca and P.	Vitamin D	62-71	calcium-binding protein	Gallus gallus	129-133
6435838-1	1984	The effect of vitamin D metabolites on parathyroid hormone secretion was studied using rat parathyroid gland cultured in basal medium Eagle containing 5% serum obtained from thyroparathyroidectomized rat, 1 mM magnesium, and calcium concentration varying from 0.75-2.25 mM, and radioimmunoassay for rat parathyroid hormone (rPTH).	Vitamin D	14-23	parathyroid hormone	Rattus norvegicus	39-58
6611007-3	1984	The results obtained in the present small number of patients suggest that the altered vitamin D metabolism and trabecular bone remodelling in patients with MCT is caused by the hypercalcitoninaemia.	Vitamin D	86-95	solute carrier family 16 member 1	Homo sapiens	156-159
6435838-3	1984	Comparison of dose-responses for inhibitory activity of some vitamin D metabolites on rPTH secretion showed: 1,25(OH)2D3 = 1,24,25(OH)3D3 greater than 1 alpha OHD3 greater than 25 OHD3.	Vitamin D	61-70	parathyroid hormone	Rattus norvegicus	86-90
6435838-5	1984	Analysis of structural activity relation of vitamin D metabolites studied indicated that 1 alpha or pseudo-1 alpha hydroxylated metabolites or analogs were active in inhibiting rPTH secretion, while, non-1 alpha hydroxylated metabolites were without or were weakly inhibitory only at very high concentrations.	Vitamin D	44-53	parathyroid hormone	Rattus norvegicus	177-181
6325646-3	1984	The synthesis of the vitamin D-induced calcium-binding protein (CaBP) was correspondingly increased.	Vitamin D	21-30	centrin 1	Homo sapiens	39-62
6088011-1	1984	Studies presented here were designed to investigate further the basis for an impaired cAMP response to parathyroid hormone (PTH) in osteoblastlike calvarial bone cells isolated from vitamin D-deficient rat pups.	Vitamin D	182-191	parathyroid hormone	Rattus norvegicus	103-122
6744632-7	1984	Restoration of normocalcaemia reduced the concentrations of bioactive PTH in both pseudohypoparathyroidism and vitamin D deficiency.	Vitamin D	111-120	parathyroid hormone	Homo sapiens	70-73
6744632-9	1984	Immunoreactive PTH was also raised in patients with untreated pseudo-hypoparathyroidism and vitamin D deficiency, but restoration of normocalcaemia did not always reduce immunoreactive PTH to normal in these patients.	Vitamin D	92-101	parathyroid hormone	Homo sapiens	15-18
6325646-3	1984	The synthesis of the vitamin D-induced calcium-binding protein (CaBP) was correspondingly increased.	Vitamin D	21-30	centrin 1	Homo sapiens	64-68
6608994-2	1984	Vitamin D replete normal mice and Hyp littermates fed the control diet synthesized primarily 24,25-dihydroxyvitamin D3 (24,25-(OH)2D3); only minimal synthesis of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) was detected in both genotypes and 1,25-(OH)2D3 formation was not significantly greater in Hyp mice relative to normal littermates, despite hypophosphatemia and hypocalcemia in the mutants.	Vitamin D	0-9	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	293-296
6321190-7	1984	This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	106-109
6608994-5	1984	Both normal and Hyp mice responded to the vitamin D-deficient diet with a fall in serum calcium (p less than 0.01), significantly increased renal 1-OHase, and significantly decreased renal 24-OHase activities.	Vitamin D	42-51	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	16-19
6608994-6	1984	In Hyp mice, the fall in serum calcium on the vitamin D-deficient diet was significantly greater than that observed on the calcium-deficient diet.	Vitamin D	46-55	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	3-6
6608994-7	1984	Therefore the ability of Hyp mice to increase renal 1-OHase activity when fed the vitamin D-deficient diet and their failure to do so on the calcium-deficient diet may be related to the resulting degree of hypocalcemia.	Vitamin D	82-91	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	25-28
6423230-5	1984	In support of the first line of thought we report here the simultaneous occurrence of two different very high affinity Ca2+ binding proteins [vitamin-D-dependent CaBP = VD CaBP and parvalbumin = PV] in bones and teeth.	Vitamin D	142-151	S100 calcium binding protein G	Homo sapiens	162-166
6423230-5	1984	In support of the first line of thought we report here the simultaneous occurrence of two different very high affinity Ca2+ binding proteins [vitamin-D-dependent CaBP = VD CaBP and parvalbumin = PV] in bones and teeth.	Vitamin D	142-151	S100 calcium binding protein G	Homo sapiens	172-176
6321190-7	1984	This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	152-155
6411203-3	1983	The raised serum parathyroid hormone concentrations in the sick elderly were not due to poor renal function and may have been a response to vitamin D deficiency.	Vitamin D	140-149	parathyroid hormone	Homo sapiens	17-36
6311881-0	1983	Effect of large oral and intravenous doses of vitamins D2 and D3 on vitamin D in milk.	Vitamin D	68-77	Weaning weight-maternal milk	Bos taurus	81-85
6356760-1	1983	Distribution of vitamin D-dependent calcium-binding proteins (CaBPs) were studied in four mammalian species using monospecific antibodies raised against chick duodenal CaBP (D-CaBP), human cerebellar CaBP (L-CaBP), and rat duodenal CaBP (S-CaBP).	Vitamin D	16-25	S100 calcium binding protein G	Homo sapiens	62-66
6853678-2	1983	The serum PTH concentrations were maximal in winter, when the vitamin D metabolites were lowest, suggesting a secondary phenomenon.	Vitamin D	62-71	parathyroid hormone	Homo sapiens	10-13
6308609-1	1983	We have constructed a recombinant cDNA library to facilitate study of the genomic actions of vitamin D3 and its hormonally active metabolite 1,25-dihydroxyvitamin D3 in initiation of the de novo biosynthesis of a 28,000-dalton vitamin D-dependent calcium binding protein (CaBP) present in chick intestine.	Vitamin D	93-102	calcium-binding protein	Gallus gallus	247-270
6308609-1	1983	We have constructed a recombinant cDNA library to facilitate study of the genomic actions of vitamin D3 and its hormonally active metabolite 1,25-dihydroxyvitamin D3 in initiation of the de novo biosynthesis of a 28,000-dalton vitamin D-dependent calcium binding protein (CaBP) present in chick intestine.	Vitamin D	93-102	calcium-binding protein	Gallus gallus	272-276
6687660-0	1983	Responsiveness of vitamin D-deficient fetal rat limb bones to parathyroid hormone in culture.	Vitamin D	18-27	parathyroid hormone	Rattus norvegicus	62-81
6687660-4	1983	The results suggest that the impaired calcemic response to parathyroid hormone seen in vitamin D-deficient animals in vivo is not the result of a specific unresponsiveness of vitamin D-deficient bone to parathyroid hormone.	Vitamin D	87-96	parathyroid hormone	Rattus norvegicus	59-78
6829752-2	1983	Addition of the intestinal vitamin D-dependent calcium-binding protein (CaBP) significantly enhanced the calcium flux at near physiological calcium concentrations (1 X 10(-6) M).	Vitamin D	27-36	centrin 1	Homo sapiens	47-70
6829752-2	1983	Addition of the intestinal vitamin D-dependent calcium-binding protein (CaBP) significantly enhanced the calcium flux at near physiological calcium concentrations (1 X 10(-6) M).	Vitamin D	27-36	centrin 1	Homo sapiens	72-76
6848514-1	1983	Five major metabolites (peaks I-V) of 25-hydroxy-24-oxovitamin D3 (25(OH)24-oxo-D3) have been isolated in pure form from in vitro incubates containing kidney homogenates of vitamin D-deficient chicks and chicks given 65 nmol of vitamin D3; peaks II, III, and V are from vitamin D-deficient chicks and peaks I, II, and IV are from vitamin D-supplemented birds.	Vitamin D	55-64	dopamine receptor D3	Gallus gallus	80-82
6688870-1	1983	To further characterize the mechanisms by which 25(OH) vitamin D3 (25(OH)D3) and 1.25(OH)2 vitamin D3 (1,25(OH)2D3) suppress the phosphaturic action of parathyroid hormone (PTH) we have studied the effects of cycloheximide (cyclohex), a protein synthesis inhibitor, on the interaction between PTH and vitamin D metabolites in parathyroidectomized (PTX) rats, both in vivo and in vitro experiments.	Vitamin D	55-64	parathyroid hormone	Rattus norvegicus	152-171
6311459-3	1983	A possible mechanism for the vitamin D resistant osteoporosis has been identified following the observation that, in those patients with severe cirrhosis, the circulating concentration of intact PTH was elevated.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	195-198
6294581-0	1983	Effect of parathyroid hormone on cAMP and 1,25-dihydroxyvitamin D formation and renal handling of phosphate in vitamin D-dependent rickets.	Vitamin D	56-65	parathyroid hormone	Homo sapiens	10-29
6847825-10	1983	The widespread distribution of immunoreactive CaBP in the central nervous system suggests that CaBP and the vitamin D endocrine system may play a significant role in the regulation of mammalian brain function.	Vitamin D	108-117	S100 calcium binding protein G	Homo sapiens	46-50
6983777-1	1982	Deficiency of vitamin D in rats led to impairment of Ca2+ absorption in intestine, hypocalcemia, decrease in specific weight of femur diaphyses, decrease in content of Ca2+ and in the ratio Ca2+/hydroxyproline in diaphyses and epiphyses.	Vitamin D	14-23	carbonic anhydrase 2	Rattus norvegicus	53-56
6689357-1	1983	The effect of graded nephron mass reduction by partial nephrectomy and the influence of parathyroid hormone and dietary phosphorus (P) on the production of 1,25-dihydroxy-vitamin D [1,25(OH)2D] were studied in vitamin D deficient rats.	Vitamin D	171-180	parathyroid hormone	Rattus norvegicus	88-107
6290192-2	1982	In vitamin D-fed rats, iv PTH as a bolus (10 USP units) elicited a phosphaturic response and an increase in urinary cAMP, whether or not the rats were thyroparathyroidectomized.	Vitamin D	3-12	parathyroid hormone	Rattus norvegicus	26-29
6290192-8	1982	(Bu)2cAMP infusion reproduced the paradoxical effect in vitamin D-fed, thyroparathyroidectomized rats receiving continuous infusion of PTH.	Vitamin D	56-65	parathyroid hormone	Rattus norvegicus	135-138
6896684-1	1982	The X-linked hypophosphatemic (Hyp) mouse presents with biochemical and skeletal abnormalities similar to those of human vitamin D-resistant rickets and hence is considered as a model of the human disease.	Vitamin D	121-130	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	31-34
6896886-0	1982	Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat.	Vitamin D	21-30	prolactin	Rattus norvegicus	8-17
6763897-1	1982	A 37-year-old woman with postoperative hypoparathyroidism had hypertension, and elevated plasma renin activity (PRA) and subsequent hyperaldosteronism during a two-month hypercalcemic period caused by vitamin D and excessive calcium supplements.	Vitamin D	201-210	renin	Homo sapiens	96-101
6897035-1	1982	The relationship between the appearance of vitamin D-dependent calcium-binding protein (CaBP) and calcium absorption was studied in sequentially isolated duodenal mucosal preparations from vitamin D-deficient chicks and those supplemented with vitamin D3 or 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)2D3].	Vitamin D	43-52	centrin 1	Homo sapiens	63-86
6897035-1	1982	The relationship between the appearance of vitamin D-dependent calcium-binding protein (CaBP) and calcium absorption was studied in sequentially isolated duodenal mucosal preparations from vitamin D-deficient chicks and those supplemented with vitamin D3 or 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)2D3].	Vitamin D	43-52	centrin 1	Homo sapiens	88-92
7051856-0	1982	Localization of the vitamin D-dependent calcium-binding protein in mammalian kidney.	Vitamin D	20-29	centrin 1	Homo sapiens	40-63
6983777-1	1982	Deficiency of vitamin D in rats led to impairment of Ca2+ absorption in intestine, hypocalcemia, decrease in specific weight of femur diaphyses, decrease in content of Ca2+ and in the ratio Ca2+/hydroxyproline in diaphyses and epiphyses.	Vitamin D	14-23	carbonic anhydrase 2	Rattus norvegicus	168-171
6983777-1	1982	Deficiency of vitamin D in rats led to impairment of Ca2+ absorption in intestine, hypocalcemia, decrease in specific weight of femur diaphyses, decrease in content of Ca2+ and in the ratio Ca2+/hydroxyproline in diaphyses and epiphyses.	Vitamin D	14-23	carbonic anhydrase 2	Rattus norvegicus	168-171
6279352-0	1982	Reversible resistance to the renal action of parathyroid hormone in human vitamin D deficiency.	Vitamin D	74-83	parathyroid hormone	Homo sapiens	45-64
6978888-0	1982	Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging.	Vitamin D	40-49	parathyroid hormone	Homo sapiens	17-36
6981649-6	1982	Collectively, these results support the hypothesis that the vitamin D-dependent intestinal CaBP may play a role in either regulation of intracellular calcium concentration or movement of calcium across the brush border membrane from the gut lumen.	Vitamin D	60-69	calcium-binding protein	Gallus gallus	91-95
7106322-3	1982	The presence of CaBP in the human placenta was examined according to Taylor and Wasserman"s method, extracting the vitamin D-dependent CaBP in the duodenum, and the character of CaBP was then studied.	Vitamin D	115-124	centrin 1	Homo sapiens	16-20
7106322-3	1982	The presence of CaBP in the human placenta was examined according to Taylor and Wasserman"s method, extracting the vitamin D-dependent CaBP in the duodenum, and the character of CaBP was then studied.	Vitamin D	115-124	centrin 1	Homo sapiens	135-139
7106322-3	1982	The presence of CaBP in the human placenta was examined according to Taylor and Wasserman"s method, extracting the vitamin D-dependent CaBP in the duodenum, and the character of CaBP was then studied.	Vitamin D	115-124	centrin 1	Homo sapiens	135-139
6279352-2	1982	The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously.	Vitamin D	120-129	parathyroid hormone	Homo sapiens	26-45
7041549-10	1982	Others, such as the nephrotic syndrome, which leads to urinary losses of the vitamin D metabolites (presumably bound to DBP), are not readily categorized.	Vitamin D	77-86	D-box binding PAR bZIP transcription factor	Homo sapiens	120-123
7036737-5	1982	As vitamin D is required for expression of the action of PTH at bone and as PTH is a prime regulator of vitamin D metabolism, the absence of either component results in important disturbances in calcium balance.	Vitamin D	3-12	parathyroid hormone	Homo sapiens	57-60
7036737-5	1982	As vitamin D is required for expression of the action of PTH at bone and as PTH is a prime regulator of vitamin D metabolism, the absence of either component results in important disturbances in calcium balance.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	76-79
6176188-0	1982	Human serum binding protein for vitamin D and its metabolites (DBP): evidence that actin is the DBP binding component in human skeletal muscle.	Vitamin D	32-41	D-box binding PAR bZIP transcription factor	Homo sapiens	63-66
6176188-0	1982	Human serum binding protein for vitamin D and its metabolites (DBP): evidence that actin is the DBP binding component in human skeletal muscle.	Vitamin D	32-41	D-box binding PAR bZIP transcription factor	Homo sapiens	96-99
7028772-0	1981	Alterations in circulating vitamin D metabolites in the young insulin-dependent diabetic.	Vitamin D	27-36	insulin	Homo sapiens	62-69
7028772-7	1981	Despite appropriate insulin replacement, alterations in vitamin D metabolism occur in the young insulin-dependent diabetic and could relate to the decrease in cortical bone mass observed in these patients.	Vitamin D	56-65	insulin	Homo sapiens	96-103
6947252-5	1981	These results suggest that the known amino acid sequence homology among calmodulin, troponin C, and S100b may be reflected in a similar functional domain present in these proteins but absent in parvalbumin and vitamin D-dependent protein.	Vitamin D	210-219	calmodulin	Bos taurus	72-82
7302575-0	1981	Stimulation of intestinal calcium transport and bone calcium mobilization by prolactin in vitamin D-deficient rats.	Vitamin D	90-99	prolactin	Rattus norvegicus	77-86
7302575-1	1981	In vitamin D-deficient rats intestinal calcium transport increased significantly 4 hours after an injection of prolactin, reached a maximum after 8 hours, and declined to preinjection levels after 24 hours.	Vitamin D	3-12	prolactin	Rattus norvegicus	111-120
7302575-2	1981	Similarly, in vitamin D-deficient rats fed a diet low in calcium or phosphorus prolactin stimulated an increase in serum calcium in both groups and an increase in serum phosphorus in the rats fed the diet low in phosphorus.	Vitamin D	14-23	prolactin	Rattus norvegicus	79-88
31252971-0	1982	The Vitamin D Activity of Milk.	Vitamin D	4-13	Weaning weight-maternal milk	Bos taurus	26-30
6271531-1	1981	The regulatory role of vitamin D in bone formation and its interaction with parathyroid hormone (PTH) were analyzed in rats in vivo.	Vitamin D	23-32	parathyroid hormone	Rattus norvegicus	76-95
6973423-8	1981	It appears that the decrease of the plasma level of these metabolites of Vitamin D precedes (or is concomitant with) the changes in the serum values of calcium (Ca), phosphorus (P) and parathyroid hormone (PTH) and the diminution of the intestinal absorption of Ca.	Vitamin D	73-82	parathyroid hormone	Homo sapiens	185-204
6788913-0	1981	Vitamin D and its metabolites in human and bovine milk.	Vitamin D	0-9	Weaning weight-maternal milk	Bos taurus	50-54
6788913-4	1981	Increasing the oral dose of vitamin D to the cows was reflected by an increase of the parent vitamin and 25-hydroxyvitamin D in the milk.	Vitamin D	28-37	Weaning weight-maternal milk	Bos taurus	132-136
6788913-5	1981	Vitamin D-binding protein concentration in human milk whey, determined by Ouchterlony immunodiffusion and radioimmunoassay, was 1--2% of the levels observed in the plasma and was dependent on the stage of lactation.	Vitamin D	0-9	Weaning weight-maternal milk	Bos taurus	49-53
6788913-6	1981	Vitamin D and its metabolites were shown initially to be present in the whey portion but with time migrated into the fat portion of milk.	Vitamin D	0-9	Weaning weight-maternal milk	Bos taurus	132-136
7026425-1	1981	The indirect immunofluorescence method is used to study the binding of the serum vitamin D carrier protein (DBP) to lymphocytes.	Vitamin D	81-90	D-box binding PAR bZIP transcription factor	Homo sapiens	108-111
7026425-4	1981	Besides, a difference in the binding to the lymphocyte membrane is observed between the holo forms of the DBP with the different vitamin D derivatives.	Vitamin D	129-138	D-box binding PAR bZIP transcription factor	Homo sapiens	106-109
7026425-5	1981	These findings could be relevant in illuminating the possible role of the DBP in the cellular metabolism of the active metabolites of vitamin D and in the cellular mobility.	Vitamin D	134-143	D-box binding PAR bZIP transcription factor	Homo sapiens	74-77
6264377-0	1981	Effect of parathyroid hormone on vitamin D metabolism in osteopetrosis.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	10-29
6894254-1	1981	Ovine prolactin stimulated the 1 alpha-hydroxylase activity in isolated renal tubules and especially in primary kidney cell cultures, both prepared from vitamin D-deficient chicks.	Vitamin D	153-162	prolactin	Homo sapiens	6-15
6259306-3	1981	Feeding of low energy diets with or without vitamin D resulted in a slower rate of growth and reduced 1-hydroxylase activity and CaBP concentration.	Vitamin D	44-53	centrin 1	Homo sapiens	129-133
6894152-2	1981	The influence of the serum binding protein (DBP) for vitamin D and its metabolites on the concentration of its main ligands, 25-hydroxyvitamin D(3) (25-OHD(3)) and 1,25-dihydroxyvitamin D(3) (1,25-[OH](2)D(3)) was studied.	Vitamin D	53-62	D-box binding PAR bZIP transcription factor	Homo sapiens	44-47
7463073-1	1981	Rats fed diets deficient in calcium or vitamin D for 4 weeks displayed hypocalcemia, as indicated by a 50% reduction in serum calcium and a sevenfold elevation of serum parathyroid hormone.	Vitamin D	39-48	parathyroid hormone	Rattus norvegicus	169-188
6975714-6	1981	Serum levels of calcium remained unchanged; the change in ALP may reflect a homeostatic mechanism controlling plasma calcium, which compensates for seasonal variations in vitamin D supply.	Vitamin D	171-180	alkaline phosphatase, placental	Homo sapiens	58-61
6791781-0	1981	Action of vitamin D metabolites on PTH secretion in man.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	35-38
6791781-5	1981	These results could be interpreted as a direct effect of metabolites of vitamin D on PTH secretion.	Vitamin D	72-81	parathyroid hormone	Homo sapiens	85-88
7014539-0	1981	Immunohistochemical localization of vitamin D-dependent calcium-binding protein in duodenum, kidney, uterus and cerebellum of chickens.	Vitamin D	36-45	calcium-binding protein	Gallus gallus	56-79
6255802-1	1980	This study reports the effects of the removal of endogenous PTH by thyroparathyroidectomy (TPTX) on the recovery of the reduced renal cAMP response to parathyroid hormone (PTH) in rats with chronically elevated PTH secondary to diets deficient in either vitamin D or calcium.	Vitamin D	254-263	parathyroid hormone	Rattus norvegicus	151-170
7009730-1	1981	The vitamin D-induced calcium-binding protein (CaBP) was localized in chick duodenum by the indirect fluorescent antibody technique after tissue was prepared by three different rapid-freezing methods: freeze-thaw, freeze-drying, and freeze-substitution.	Vitamin D	4-13	calcium-binding protein	Gallus gallus	22-45
7009730-1	1981	The vitamin D-induced calcium-binding protein (CaBP) was localized in chick duodenum by the indirect fluorescent antibody technique after tissue was prepared by three different rapid-freezing methods: freeze-thaw, freeze-drying, and freeze-substitution.	Vitamin D	4-13	calcium-binding protein	Gallus gallus	47-51
6254964-0	1980	Renal parathyroid hormone-dependent adenylate cyclase in vitamin D-deficient rats.	Vitamin D	57-66	parathyroid hormone	Rattus norvegicus	6-25
6893594-6	1980	The binding protein has probably a single binding site for all vitamin D metabolites and its association constant for 25-OH-D3 at 4 degrees C and pH 7.4 is 10(9) M-1.	Vitamin D	63-72	dopamine receptor D3	Gallus gallus	118-126
6246136-4	1980	The evidence presented suggests that the resistance of PTH in this patient was due to secondary hyperparathyroidism rather than to a defect of PTH-sensitive receptors of the kidney and bone or to inadequacy of vitamin D per se.	Vitamin D	210-219	parathyroid hormone	Homo sapiens	55-58
6892897-1	1980	We studied the effect of PRL from two species (bovine and turkey) and GH from two species (bovine and turkey) on 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production by two whole cell preparations from vitamin D-deficient chick kidneys (slices and tubules).	Vitamin D	127-136	prolactin	Bos taurus	25-28
6251904-0	1980	Renal parathyroid hormone-dependent adenylate cyclase activity after repletion of vitamin D-deficient rats with vitamin D-2.	Vitamin D	82-91	parathyroid hormone	Rattus norvegicus	6-25
6251904-1	1980	Rats fed a diet deficient in both vitamin D and Ca2+ exhibited a greater depression of the renal parathyroid hormone (PTH)-dependent adenylate cyclase than was observed in rats fed diets deficient in either vitamin D or calcium.	Vitamin D	34-43	parathyroid hormone	Rattus norvegicus	97-116
6252763-0	1980	Renal receptors for parathyroid hormone in normal, parathyroidectomized and vitamin D-deficient rats.	Vitamin D	76-85	parathyroid hormone	Rattus norvegicus	20-39
92374-1	1979	The binding properties towards vitamin D metabolites of plasma from individuals with the three common Gc-globulin phenotypes, Gc-1, Gc-2 and Gc-2-1, have been found to be identical.	Vitamin D	31-40	solute carrier family 25 member 18	Homo sapiens	132-136
443376-1	1979	The concentration of the vitamin D-induced calcium-binding protein (CaBP) and calcium absorption from the duodenum were investigated in chicks with an in vivo ligated-loop technique.	Vitamin D	25-34	centrin 1	Homo sapiens	43-66
443376-1	1979	The concentration of the vitamin D-induced calcium-binding protein (CaBP) and calcium absorption from the duodenum were investigated in chicks with an in vivo ligated-loop technique.	Vitamin D	25-34	centrin 1	Homo sapiens	68-72
443376-2	1979	The relation between CaBP and calcium absorption was dependent on a) source of vitamin D activity (either vitamin D3 or 1,25-dihydroxycholecalciferol); b) dosage of vitamin D3; c) time after administration of vitamin D3 to rachitic animals.	Vitamin D	79-88	centrin 1	Homo sapiens	21-25
443376-4	1979	The model, when applied to the data, suggests that there is a "nonfunctional" pool of CaBP the size of which is determined by the vitamin D status of the animal.	Vitamin D	130-139	centrin 1	Homo sapiens	86-90
225161-3	1979	With the combined calcium-PTH infusion or PTH infusion after vitamin D therapy, renal response was improved in these patients.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	42-45
217686-0	1979	Parathyroid hormone and calcitonin levels in vitamin D deficient rickets.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	0-19
217686-0	1979	Parathyroid hormone and calcitonin levels in vitamin D deficient rickets.	Vitamin D	45-54	calcitonin related polypeptide alpha	Homo sapiens	24-34
6253269-0	1980	Effects in vivo of vitamin D metabolites and 17 beta-estradiol on parathyroid hormone-dependent formation of adenosine 3",5"-monophosphate in rat bone.	Vitamin D	19-28	parathyroid hormone	Rattus norvegicus	66-85
6253269-1	1980	We used an in vivo infusion technique to assess the hypothesis that vitamin D metabolites and estrogens modulate tissue responsiveness to parathyroid hormone via effects on the adenylate cyclase-cAMP system.	Vitamin D	68-77	parathyroid hormone	Rattus norvegicus	138-157
6251904-1	1980	Rats fed a diet deficient in both vitamin D and Ca2+ exhibited a greater depression of the renal parathyroid hormone (PTH)-dependent adenylate cyclase than was observed in rats fed diets deficient in either vitamin D or calcium.	Vitamin D	207-216	parathyroid hormone	Rattus norvegicus	97-116
6246136-1	1980	Serum immunoreactive parathyroid hormone (PTH) levels were increased in a 50-yr-old man with a unique variant of adult-onset vitamin D-resistant osteomalacia, presenting with high phosphate clearance, mild hypocalcemia, and blunted hypercalcemic and phosphaturic responses to exogenous parathyroid extract.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	21-40
6246136-1	1980	Serum immunoreactive parathyroid hormone (PTH) levels were increased in a 50-yr-old man with a unique variant of adult-onset vitamin D-resistant osteomalacia, presenting with high phosphate clearance, mild hypocalcemia, and blunted hypercalcemic and phosphaturic responses to exogenous parathyroid extract.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	42-45
7357340-4	1980	These results suggest that prolactin and growth hormone are important regulators of renal vitamin D metabolism in the physiological conditions of pregnancy, lactation, and growth in man.	Vitamin D	90-99	prolactin	Homo sapiens	27-36
7357340-4	1980	These results suggest that prolactin and growth hormone are important regulators of renal vitamin D metabolism in the physiological conditions of pregnancy, lactation, and growth in man.	Vitamin D	90-99	growth hormone 1	Homo sapiens	41-55
7398339-2	1980	The conspicuous effect of 1 alpha-OH-D3 on pseudohypoparathyroidism is likely to be attributed to the fact that the unresponsiveness of bone tissue to parathyroid hormone is corrected by the action of active vitamin D.	Vitamin D	208-217	parathyroid hormone	Homo sapiens	151-170
6249541-4	1980	These vitamin D derivatives also increased the PTH-degrading activity of kidney tissue when they were added in vitro.	Vitamin D	6-15	parathyroid hormone	Rattus norvegicus	47-50
6995015-0	1980	PTH-vitamin D interrelationships.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	0-3
7353372-0	1980	Do vitamin D or its metabolites directly affect the release of PTH?	Vitamin D	3-12	parathyroid hormone	Homo sapiens	63-66
6894194-0	1980	Vitamin D transport - the nature of the interaction between plasma DBP and tissue protein.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	67-70
6894194-1	1980	The plasma-binding protein for vitamin D and its metabolites (DBP) is bound with high affinity (KA approximately 10(7) M-1) and specificity by a 40,000-dalton protein which is a proven constituent of all tissue cytosols examined.	Vitamin D	31-40	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
484524-4	1979	We conclude that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary Ca intake is normal.	Vitamin D	129-138	solute carrier family 6 member 2	Homo sapiens	17-20
457839-0	1979	Parathyroid function and vitamin D metabolism during human growth hormone replacement.	Vitamin D	25-34	growth hormone 1	Homo sapiens	59-73
91467-1	1979	Vitamin D and its metabolites are bound to an alpha globulin (DBP) in human serum.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
496922-0	1979	The influence of growth hormone on vitamin D metabolism.	Vitamin D	35-44	growth hormone 1	Homo sapiens	17-31
761406-0	1979	A method for studying plasma transport of vitamin D applicable to hypervitaminosis D. In man, vitamin D is normally transported on a specific binding globulin (DBP) and on lipoproteins.	Vitamin D	42-51	D-box binding PAR bZIP transcription factor	Homo sapiens	160-163
761406-0	1979	A method for studying plasma transport of vitamin D applicable to hypervitaminosis D. In man, vitamin D is normally transported on a specific binding globulin (DBP) and on lipoproteins.	Vitamin D	94-103	D-box binding PAR bZIP transcription factor	Homo sapiens	160-163
761406-3	1979	This method completely separates DBP from albumin and thus enables the quantification of vitamin D bound to these proteins in various clinical and experimental conditions.	Vitamin D	89-98	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
217350-0	1978	Stimulation of intestinal calcium-binding-protein mRNA synthesis in the nucleus of vitamin D-deficient chicks by 1,25-dihydroxycholecalciferol.	Vitamin D	83-92	centrin 1	Homo sapiens	26-49
357647-1	1978	Calcium binding protein (CaBP) was localized by the indirect peroxidase-labeled antibody method in chick duodenum 72 hr after administering 32.5 nmol of cholecalciferol to vitamin D-deficient chicks.	Vitamin D	172-181	calcium-binding protein	Gallus gallus	0-23
357647-1	1978	Calcium binding protein (CaBP) was localized by the indirect peroxidase-labeled antibody method in chick duodenum 72 hr after administering 32.5 nmol of cholecalciferol to vitamin D-deficient chicks.	Vitamin D	172-181	calcium-binding protein	Gallus gallus	25-29
308475-0	1978	Vitamin D metabolism in bullfrogs and Japanese quail: effects of estradiol and prolactin.	Vitamin D	0-9	prolactin	Coturnix japonica	79-88
643088-0	1978	Effect of growth hormone on vitamin D metabolism.	Vitamin D	28-37	growth hormone 1	Homo sapiens	10-24
213000-3	1978	(3)Prolactin and growth hormone are importnat regulators of vitamin D metabolism during pregnancy and growth.	Vitamin D	60-69	growth hormone 1	Homo sapiens	17-31
717102-8	1978	This may suggest that the stimulating effect of biologically active vitamin D on the tubular reabsorption of phosphate is mediated via the parallel suppression of PTH, but does not exclude that biologically active vitamin D exerts a direct effect on the human renal tubule.	Vitamin D	68-77	parathyroid hormone	Homo sapiens	163-166
204303-0	1978	The relationship between vitamin D-stimulated calcium transport and intestinal calcium-binding protein in the chicken.	Vitamin D	25-34	calcium-binding protein	Gallus gallus	79-102
196836-1	1977	Teh stimulatory effect of parathyroid hormone (PTH) on renal 1alpha-hydroxylation of 25-hydroxyvitamin D3 (25-OH-D3) was studied in thyro-parathyroidectomized (TPTX), vitamin D-deficient rats into which bovine PTH, theophylline, cAMP or dibutyryl cAMP (dbcAMP) was constantly infused.	Vitamin D	95-104	parathyroid hormone	Rattus norvegicus	26-45
402385-1	1977	This study reports the development of a specific and sensitive radioimmunoassay and a simple and accurate radial immunodiffusion (RID) assay for the human serum-binding protein for vitamin D and its metabolites (DBP).	Vitamin D	181-190	D-box binding PAR bZIP transcription factor	Homo sapiens	212-215
1086857-1	1976	A radioimmunoassay for the binding protein for vitamin D and its metabolites (DBP) has been developed.	Vitamin D	47-56	D-box binding PAR bZIP transcription factor	Homo sapiens	78-81
787723-18	1976	An increase in plasma calcium in response to PTH can occur either in the untreated state or after treatment with vitamin D because either the error-correcting or remodeling system remains responsive to PTH.	Vitamin D	113-122	parathyroid hormone	Homo sapiens	45-48
787723-18	1976	An increase in plasma calcium in response to PTH can occur either in the untreated state or after treatment with vitamin D because either the error-correcting or remodeling system remains responsive to PTH.	Vitamin D	113-122	parathyroid hormone	Homo sapiens	202-205
956382-2	1976	This study reports the isolation and partial characterization of vitamin D and 25-hydroxyvitamin D binding protein (DBP), the specific transport protein for vitamin D and its 25-hydroxy metabolite in human plasma.	Vitamin D	65-74	D-box binding PAR bZIP transcription factor	Homo sapiens	116-119
953799-0	1976	The effects of vitamin D metabolites and their analogues on the secretion of parathyroid hormone.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	77-96
956382-2	1976	This study reports the isolation and partial characterization of vitamin D and 25-hydroxyvitamin D binding protein (DBP), the specific transport protein for vitamin D and its 25-hydroxy metabolite in human plasma.	Vitamin D	89-98	D-box binding PAR bZIP transcription factor	Homo sapiens	116-119
1112253-1	1975	The effect of dietary vitamin D levels on the response to iv injected parathyroid hormone (PTH) was studies in chicks fed one of three diets: D-deficient, Control-D (1.4IU cholecalciferol/g diet), or High-D (70 IU cholecalciferol/g diet) during the first 4 weeks post-hatching.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	70-89
180058-1	1976	To determine whether the phosphaturic response to circulating parathyroid hormone (PTH) is exaggerated in patients with familial x-linked hypophosphatemic vitamin D-resistant rickets (FHR), we examined the phosphaturic response to parathyroid extract (PTE) (administered intravenously in the posthypercalcemic state) in two unrelated adult hemizygotes with FHR.	Vitamin D	155-164	parathyroid hormone	Homo sapiens	62-81
1192645-4	1975	Cartilage lysozyme levels are low in rickets, while vitamin D increases it in both cartilage and aorta, suggesting an association between lysozyme and the calcification process.	Vitamin D	52-61	lysozyme	Homo sapiens	138-146
172936-11	1975	Thus the relationship between parathyroid hormone and metabolites of vitamin D may not be mediated through changes in serum calcium alone, and it is postulated that metabolites of vitamin D may directly affect the secretion of parathyroid hormone.	Vitamin D	69-78	parathyroid hormone	Homo sapiens	30-49
172936-11	1975	Thus the relationship between parathyroid hormone and metabolites of vitamin D may not be mediated through changes in serum calcium alone, and it is postulated that metabolites of vitamin D may directly affect the secretion of parathyroid hormone.	Vitamin D	180-189	parathyroid hormone	Homo sapiens	227-246
1166791-4	1975	Under these conditions there was a significant decrease in the filtered fraction of phosphate and amino acid excreted in the vitamin D resistant group suggesting a depression of parathyroid hormone secretion.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	178-197
1166791-5	1975	It seems likely, as demonstrated in the vitamin D resistant group, that in this disorder the renal tubule is particularly sensitive to changes in parathyroid hormone secretion in respect to amino acid reabsorption.	Vitamin D	40-49	parathyroid hormone	Homo sapiens	146-165
169419-0	1975	Influence of dialysate calcium concentration and vitamin D on serum parathyroid hormone during repetitive dialysis.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	68-87
171472-3	1975	Even during vitamin D treatment renal camp formation by giving PTH extract cannot be stimulated, while in this situation.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	63-66
171472-5	1975	Whether this is due to a PTH potentiated vitamin D effect is discussed.	Vitamin D	41-50	parathyroid hormone	Homo sapiens	25-28
1090646-0	1975	Fluorescent antibody localization of the vitamin D-dependent calcium-binding protein in the oviduct of the laying hen.	Vitamin D	41-50	centrin 1	Homo sapiens	61-84
4431686-0	1974	[Calcium-binding protein--1 of the indicators of the effectiveness of rickets prevention with vitamin D (according to data of experimental studies)].	Vitamin D	94-103	calcium binding protein 1	Homo sapiens	1-27
178845-2	1975	The enzyme activity was significantly decreased in the combination with microsomes obtained from either vitamin D-deficient or vitamin D3-treated rat liver and with SCP obtained from vitamin D3-treated rat.	Vitamin D	104-113	fatty acid binding protein 1	Rattus norvegicus	165-168
4462587-3	1974	The synthesis of calcium-binding protein, a protein produced in the small intestine in response to vitamin D, was investigated with a view to determining whether calcium-binding-protein production could be correlated with the stimulation of calcium absorption by vitamin D.	Vitamin D	99-108	centrin 1	Homo sapiens	17-40
4462587-7	1974	When used on intestinal supernatants from chicks dosed with vitamin D, calcium-binding protein was not detectable at 8h but was present after 12h at a concentration of 8.6mug/g wet wt.	Vitamin D	60-69	centrin 1	Homo sapiens	71-94
4462587-10	1974	The synthesis of calcium-binding protein was also monitored directly by making use of the ability of the iodinated antiserum to bind specifically to nascent calcium-binding protein chains on intestinal polyribosomes; in this way calcium-binding-protein synthesis could be detected 8h after dosage with vitamin D.	Vitamin D	302-311	centrin 1	Homo sapiens	17-40
4462587-16	1974	It is concluded that the high correlation between the initiation of calcium-binding-protein synthesis and the stimulation of calcium absorption by vitamin D strengthens the proposal that calcium-binding protein plays an important role in calcium transport.	Vitamin D	147-156	centrin 1	Homo sapiens	187-210
4369169-0	1974	Serum parathyroid hormone concentrations in hypophosphataemic vitamin D resistant rickets.	Vitamin D	62-71	parathyroid hormone	Homo sapiens	6-25
4275650-0	1974	Influence of parathyroid hormone on ultrastructural and enzymatic changes induced by vitamin D in bone of thyroparathyroidectomized rats.	Vitamin D	85-94	parathyroid hormone	Rattus norvegicus	13-32
4355232-0	1973	Parathyroid hormone secretion in familial vitamin-D-resistant rickets.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	0-19
4358425-0	1973	Serum parathyroid hormone concentrations in vitamin D deficiency rickets of infancy: effects of intravenous calcium and vitamin D.	Vitamin D	44-53	parathyroid hormone	Homo sapiens	6-25
5086060-0	1972	Vitamin D effects on tissue and serum lysozyme.	Vitamin D	0-9	lysozyme	Homo sapiens	38-46
1086857-11	1976	No significant correlation between serum DBP levels and serum 25-hydroxycalciferol levels was found, and the DBP content of sera from vitamin D-deprived and vitamin D-treated subjects was indistinguishable from that of normal adults.	Vitamin D	157-166	D-box binding PAR bZIP transcription factor	Homo sapiens	109-112
4339535-0	1972	Serum parathyroid hormone in hypophosphatemic vitamin D-resistant rickets.	Vitamin D	46-55	parathyroid hormone	Homo sapiens	6-25
4338789-0	1972	Parathyroid hormone as a trophic hormone for 1,25-dihydroxyvitamin D3, the metabolically active form of vitamin D.	Vitamin D	59-68	parathyroid hormone	Homo sapiens	0-19
4340153-4	1972	It appears that the parathyroid hormone serves as a tropin for production of 1,25-dihydroxycholecalciferol, the hormonal form of vitamin D responsible for calcium mobilization from intestinal contents and bone.	Vitamin D	129-138	parathyroid hormone	Rattus norvegicus	20-39
4538286-0	1972	A case of adult-onset vitamin-D resistant osteomalacia with elevated plasma parathyroid hormone level.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	76-95
31291127-5	2021	Vitamin D deficiency affects the renin-angiotensin system leading to ventricular hypertrophy and eventually to stroke.	Vitamin D	0-9	renin	Homo sapiens	33-38
4349621-0	1972	Nature of defect responsible for familial vitamin D-resistant rickets (VDRR) based on radioimmunoassay for parathyroid hormone (PTH).	Vitamin D	42-51	parathyroid hormone	Homo sapiens	107-126
5129305-8	1971	The resorptive response to hypophosphatemia, as previously shown for the resorptive response to excess endogenous parathyroid hormone, was partially inhibited by vitamin D deficiency.	Vitamin D	162-171	parathyroid hormone	Rattus norvegicus	114-133
5553330-0	1971	The relationship between the actions of vitamin D, parathyroid hormone and calcitonin.	Vitamin D	40-49	calcitonin related polypeptide alpha	Homo sapiens	75-85
19873640-1	1969	Several proteins from various animal tissues with possible transport function have been briefly described, with emphasis given to a vitamin D-induced calcium-binding protein (CaBP) implicated in calcium translocation across epithelial membranes.	Vitamin D	132-141	calcium-binding protein	Gallus gallus	150-173
19873640-1	1969	Several proteins from various animal tissues with possible transport function have been briefly described, with emphasis given to a vitamin D-induced calcium-binding protein (CaBP) implicated in calcium translocation across epithelial membranes.	Vitamin D	132-141	calcium-binding protein	Gallus gallus	175-179
6050348-0	1967	The parathyroid hormone and aminoaciduria in vitamin-D deficiency rickets.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	4-23
6036323-0	1967	Relationship between vitamin D deficiency, thyrocalcitonin, and parathyroid hormone.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	64-83
14421382-0	1959	[Indispensable role of vitamin D in demonstrating the hypercalcemic action of parathyroid hormone in the normal rat].	Vitamin D	23-32	parathyroid hormone	Rattus norvegicus	78-97
33716049-6	2021	Indeed, CYP11A1 plays several critical roles in the skin through its initiation of local steroidogenesis and specific metabolism of vitamin D, lumisterol, and 7-dehydrocholesterol.	Vitamin D	132-141	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	8-15
33558959-15	2021	Low BMD is 3.3 times more frequent in NF1 than in general population, with high fracture risk, regardless of the skin phenotype, classical or at risk, because of high bone turn over and secondary hyperparathyroidism due to vitamin D deficiency and poor calcium intake.	Vitamin D	223-232	neurofibromin 1	Homo sapiens	38-41
33792853-10	2021	Experimental studies have demonstrated that low vitamin D may be implicated in adipose tissue differentiation and growth leading to obesity either by regulation of gene expression or through modulation of parathyroid hormone, calcium, and leptin.	Vitamin D	48-57	parathyroid hormone	Homo sapiens	205-224
33713690-5	2021	This highly polymorphic protein is not only the major transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites, but also participates in the transport of the 25(OH)D into the cell via a megalin/cubilin complex.	Vitamin D	133-142	albumin	Homo sapiens	90-97
33387018-9	2021	In a multivariate analysis, TNF-alpha positively associated with phosphorus, PTH, and alkaline phosphatase and inversely associated with height z-score, independent of kidney function, age, sex, and active vitamin D analogue use.	Vitamin D	206-215	tumor necrosis factor	Homo sapiens	28-37
33894440-1	2021	As a response to low levels of vitamin D serum Parathyroid Hormone (iPTH) is increased in some, but not all, patients.	Vitamin D	31-40	parathyroid hormone	Homo sapiens	47-66
34045549-0	2021	Vitamin D stimulates miR-26b-5p to inhibit placental COX-2 expression in preeclampsia.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
34045549-3	2021	This study was to investigate if vitamin D can benefit preeclampsia by inhibiting placental COX-2 expression.	Vitamin D	33-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97
34013677-5	2021	RESULTS: The LC-MS/MS method using a Cookson-type derivatization reagent phenyl-1,2,4-triazoline-3,5-dione (PTAD) quantifies 13 vitamin D metabolites, including mono and dihydroxy-metabolites, as well as CYP11A1-derived D3 and D2 metabolites in a single run.	Vitamin D	128-137	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	204-211
34021020-1	2021	OBJECTIVE: To evaluate the efficacy of aluminum-formulated intralymphatic glutamic acid decarboxylase (GAD-alum) therapy combined with vitamin D supplementation in preserving endogenous insulin secretion in all patients with type 1 diabetes (T1D) or in a genetically prespecified subgroup.	Vitamin D	135-144	insulin	Homo sapiens	186-193
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	solute carrier family 6 member 4	Homo sapiens	206-236
34009686-2	2021	Alpha-fetoprotein, Vitamin D and E binding proteins are part of the albumin family and these are produced exclusively in the liver.	Vitamin D	19-28	albumin	Homo sapiens	68-75
34055120-12	2021	In addition, serum levels of vitamin D and circulated plasma markers of inflammation and bone metabolism such as CRP, IL-6, TNF-alpha, s-Ca, s-BAP, s-OC, and s-NTX were significantly reduced in severe LBP cases compared to those with minimal LBP scores.	Vitamin D	29-38	interleukin 6	Homo sapiens	118-122
34055120-12	2021	In addition, serum levels of vitamin D and circulated plasma markers of inflammation and bone metabolism such as CRP, IL-6, TNF-alpha, s-Ca, s-BAP, s-OC, and s-NTX were significantly reduced in severe LBP cases compared to those with minimal LBP scores.	Vitamin D	29-38	tumor necrosis factor	Homo sapiens	124-133
33722593-0	2021	COVID-19 and IL-6: Why Vitamin D (probably) helps but tocilizumab might not.	Vitamin D	23-32	interleukin 6	Homo sapiens	13-17
33722593-2	2021	Could Vitamin D, which modulates IL-6, be more effective than currently deployed IL-6 antagonists, including tocilizumab, thereby presenting a useful therapeutic option in COVID-19?	Vitamin D	6-15	interleukin 6	Homo sapiens	33-37
33722593-5	2021	While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6.	Vitamin D	102-111	interleukin 6	Homo sapiens	131-135
33722593-5	2021	While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6.	Vitamin D	102-111	interleukin 6	Homo sapiens	131-135
33722593-6	2021	Vitamin D may have advantages over tocilizumab as an IL-6 immunomodulator, and, given that it is safe if administered under clinical supervision, there is a strong rationale for its use.	Vitamin D	0-9	interleukin 6	Homo sapiens	53-57
33990871-2	2021	Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection   Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites What is New?	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	131-134
33990871-2	2021	Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection   Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites What is New?	Vitamin D	0-9	albumin	Homo sapiens	183-190
33990871-2	2021	Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection   Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites What is New?	Vitamin D	226-235	D-box binding PAR bZIP transcription factor	Homo sapiens	131-134
33990871-2	2021	Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection   Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites What is New?	Vitamin D	226-235	albumin	Homo sapiens	183-190
34033278-0	2021	Moderator role of vitamin D concentrations on the association between metabolic syndrome and C-reactive protein among adults.	Vitamin D	18-27	C-reactive protein	Homo sapiens	93-111
33960201-2	2021	We sought to determine whether vitamin D supplementation reduces biomarkers of insulin resistance, inflammation, neurohormonal activation, and lipids.	Vitamin D	31-40	insulin	Homo sapiens	79-86
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	solute carrier family 6 member 4	Homo sapiens	238-242
33172753-1	2021	ABCB1 (P-glycoprotein/MDR1) is a multidrug efflux transporter that has previously been involved in cholesterol and vitamin D metabolism.	Vitamin D	115-124	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	0-5
33974698-0	2021	Retraction of Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial.	Vitamin D	14-23	insulin	Homo sapiens	79-86
33974699-0	2021	Retraction of Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women.	Vitamin D	14-23	C-reactive protein	Homo sapiens	71-89
33974699-0	2021	Retraction of Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women.	Vitamin D	14-23	insulin	Homo sapiens	91-98
31049899-0	2021	Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration.	Vitamin D	75-84	insulin	Homo sapiens	0-7
31049899-14	2021	CONCLUSION: The serum concentration of Vitamin D is negatively associated with insulin resistance in patients with T1DM and may have clinical implications.	Vitamin D	39-48	insulin	Homo sapiens	79-86
33759562-7	2021	Collectively, these data suggest that vitamin D/VDR signaling relieves colitis development in animal models, at least in part, by suppressing HIF-1alpha expression in colonic epithelial cells.	Vitamin D	38-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-152
34008824-0	2021	Vitamin D Supplementation Induces Cardiac Remodeling in Rats: Association with Thioredoxin-Interacting Protein and Thioredoxin.	Vitamin D	0-9	thioredoxin 1	Rattus norvegicus	79-90
33749495-9	2021	Vitamin D activity can oppose JNK/p38 activation.	Vitamin D	0-9	mitogen-activated protein kinase 8	Homo sapiens	30-33
33749495-9	2021	Vitamin D activity can oppose JNK/p38 activation.	Vitamin D	0-9	mitogen-activated protein kinase 14	Homo sapiens	34-37
33172753-1	2021	ABCB1 (P-glycoprotein/MDR1) is a multidrug efflux transporter that has previously been involved in cholesterol and vitamin D metabolism.	Vitamin D	115-124	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	22-26
33420892-12	2021	CONCLUSIONS: The prevalence of vitamin D deficiency was higher in patients with eGFR 30 - < 60 mL/min/1.73 m2 than those with eGFR >= 60 mL/min/1.73 m2.	Vitamin D	31-40	epidermal growth factor receptor	Homo sapiens	80-84
33994379-10	2021	On univariate analysis i-PTH was significantly associated with sex, eGFR, serum calcium, and 25(OH) vit-D level and no association was found with age and FGF-23 levels.	Vitamin D	100-105	parathyroid hormone	Homo sapiens	25-28
33512007-5	2021	CONCLUSION: Elevated vitamin D levels could decrease COVID-19 PCR positivity,D-dimer and CRP levels and the number of affected lung segments in COVID-19 positive patients,thereby shortening duration of hospital stays and alleviating the intensity of COVID-19.	Vitamin D	21-30	C-reactive protein	Homo sapiens	89-92
33847289-12	2021	Early termination of anti-TNF therapy was significantly higher in patients who had vitamin D insufficiency (14.5% vs 0%, P = 0.034).	Vitamin D	83-92	tumor necrosis factor	Homo sapiens	26-29
33760145-5	2021	It has been reported that vitamin D could prevent the occurrence of antiphospholipid syndrome (APS) by reducing the expression levels of anti-beta2 glycoprotein and tissue factor in RPL cases with APS.	Vitamin D	26-35	ATPase H+ transporting V0 subunit a2	Homo sapiens	142-147
33150500-14	2021	Higher serum vitamin D levels may have roles in development of lower levels of PTH and higher levels of serum and urine calcium, leading to stone formation.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	79-82
33995282-0	2021	Combined Effects of Vitamin D Status, Renal Function and Age on Serum Parathyroid Hormone Levels.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	70-89
33995282-1	2021	Background: Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	95-114
33995282-1	2021	Background: Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	116-119
33995282-11	2021	Conclusions: We showed that declining vitamin D and renal function have additive effects on serum PTH in subjects without vitamin D deficiency.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	98-101
33932442-0	2021	Vitamin D supplementation decreases visceral adiposity and normalizes leptinemia and circulating TNF-alpha levels in western diet-fed obese rats.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	97-106
33966706-1	2021	Gestational diabetes mellitus(GDM)can cause blood glucose disorders in pregnant women and result in adverse maternal-neonatal outcomes.Vitamin D(VD)can improve glucose tolerance and insulin sensitivity,and thus theoretically,VD supplementation during pregnancy could improve glycemic control as well as maternal-neonatal outcomes in GDM patients.Although studies have shown that VD deficiency is associated with poor maternal-neonatal outcomes in GDM patients,no solid conclusion has been drawn with regard to the effects of VD supplementation on these patients.Therefore,here we summarized the research progress of the effects of VD supplementation on glycemic control and adverse maternal-neonatal outcomes in GDM patients,in an effort to guide the clinical VD supplementation during pregnancy.	Vitamin D	135-144	insulin	Homo sapiens	182-189
33895867-5	2021	Vitamin D supplementation had an inconsistent effect on PTH concentrations and meta-analysis showed non- significant reduction (P = 0.08) whereas calcifediol, calcitriol and paricalcitol consistently reduced PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	56-59
33882819-3	2021	Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR).	Vitamin D	18-27	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	81-88
33923622-13	2021	A positive correlation was found between vitamin D level and SMP-30.	Vitamin D	41-50	regucalcin	Rattus norvegicus	61-67
33851280-7	2021	In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.	Vitamin D	21-30	CTD	Homo sapiens	202-205
33836827-8	2021	Treatment of hADMSCs with vitamin D plus BPA (0.1 nM) significantly inhibited the induction of PPARgamma, C/EBP beta, C/EBP alpha, and FASN related to adipocyte differentiation and development.	Vitamin D	26-35	peroxisome proliferator activated receptor gamma	Homo sapiens	95-104
33836827-8	2021	Treatment of hADMSCs with vitamin D plus BPA (0.1 nM) significantly inhibited the induction of PPARgamma, C/EBP beta, C/EBP alpha, and FASN related to adipocyte differentiation and development.	Vitamin D	26-35	CCAAT enhancer binding protein alpha	Homo sapiens	106-116
33836827-8	2021	Treatment of hADMSCs with vitamin D plus BPA (0.1 nM) significantly inhibited the induction of PPARgamma, C/EBP beta, C/EBP alpha, and FASN related to adipocyte differentiation and development.	Vitamin D	26-35	CCAAT enhancer binding protein alpha	Homo sapiens	118-129
33836827-10	2021	The remarkable increase in the level of SREBP1c was associated to the suppression of INSIG2 in treated preadipocytes with 10 nM vitamin D plus BPA.	Vitamin D	128-137	insulin induced gene 2	Homo sapiens	85-91
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	estrogen receptor 1	Homo sapiens	48-54
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	estrogen receptor 1	Homo sapiens	190-196
33832495-2	2021	The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores.	Vitamin D	159-168	interleukin 6	Homo sapiens	217-221
33832495-2	2021	The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores.	Vitamin D	159-168	CD4 molecule	Homo sapiens	234-237
33832495-2	2021	The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores.	Vitamin D	159-168	lipase I	Homo sapiens	296-300
33823104-1	2021	OBJECTIVES: Vitamin D dependent rickets type 1A (VDDR-1A) is a very rare autosomal recessive disorder caused by mutations in the CYP27B1, which encodes vitamin D 1alpha-hydroxylase.	Vitamin D	12-21	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-136
33418034-0	2021	Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice.	Vitamin D	87-96	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	110-115
31914352-9	2021	There was significant positive correlation between serum vitamin D and Th1 cytokines IL-2 and IL-8 as well as Th2 cytokines (ILs-3, 4, 5 and 9), but negative correlation with IL-13Conclusions: Serum Vitamin D and cytokines were lower in a sample of Nigerian children with asthma than controls.	Vitamin D	57-66	interleukin 2	Homo sapiens	85-89
31914352-9	2021	There was significant positive correlation between serum vitamin D and Th1 cytokines IL-2 and IL-8 as well as Th2 cytokines (ILs-3, 4, 5 and 9), but negative correlation with IL-13Conclusions: Serum Vitamin D and cytokines were lower in a sample of Nigerian children with asthma than controls.	Vitamin D	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
33596158-0	2021	l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes.	Vitamin D	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Vitamin D	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	240-253
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Vitamin D	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	255-259
33847289-0	2021	The Impact of Vitamin D on Response to Anti-tumor Necrosis Factor-alpha Therapy in Children With Inflammatory Bowel Disease.	Vitamin D	14-23	tumor necrosis factor	Homo sapiens	44-71
33760197-0	2021	MicroRNA-378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells.	Vitamin D	51-60	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	23-28
33912936-3	2021	Although vitamin D inhibits inflammation and ameliorates SHPT, the contribution of vitamin D deficiency to SHPT via local NF-kappaB activation remains to be clarified.	Vitamin D	83-92	nuclear factor kappa B subunit 1	Homo sapiens	122-131
33912936-12	2021	Vitamin D deficiency may be involved in SHPT via the activation of NF-kappaB pathway.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	67-76
32812524-12	2021	These results provide experimental evidence that long-term vitamin D deficiency promotes renal fibrosis and functional impairment, at least partially, through aggravating TGF-beta/Smad2/3-mediated EMT in middle-aged male mice.	Vitamin D	59-68	SMAD family member 2	Mus musculus	180-187
33893820-4	2021	CASE PRESENTATION: The patient was a 59-year-old asymptomatic woman who consistently showed elevated PTH levels (385-482 pg/ml) using the Roche Elecsys (Cobas e-411) and ADVIA Centaur assays, with normal calcium, phosphorus, vitamin D, and renal function parameters.	Vitamin D	225-234	parathyroid hormone	Homo sapiens	101-104
33890506-8	2021	Higher levels of serum IL-6 were observed in patients with vitamin D deficiency (P = 0.022).	Vitamin D	59-68	interleukin 6	Homo sapiens	23-27
33890506-12	2021	CONCLUSION: Vitamin D deficiency in knee OA seems to be associated with a higher release of IL-6.	Vitamin D	12-21	interleukin 6	Homo sapiens	92-96
33890506-13	2021	Therefore, vitamin D supplementation could reduce the disease burden by controlling the IL-6 release.	Vitamin D	11-20	interleukin 6	Homo sapiens	88-92
33922669-0	2021	Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration.	Vitamin D	59-68	renin binding protein	Homo sapiens	158-161
33883570-6	2021	Protein-protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-kappaB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients.	Vitamin D	64-73	nuclear factor kappa B subunit 1	Homo sapiens	126-135
33920130-5	2021	The known factors affecting vitamin D metabolism interfere with cytochrome CYP3A4 activity.	Vitamin D	28-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81
33854388-0	2021	Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus.	Vitamin D	0-9	insulin	Homo sapiens	50-57
33854388-1	2021	Purpose: This study aimed to examine whether 25-hydroxyvitamin D (25OHD) levels (an indicator of vitamin D status) are independently associated with insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).	Vitamin D	55-64	insulin	Homo sapiens	149-156
33420892-12	2021	CONCLUSIONS: The prevalence of vitamin D deficiency was higher in patients with eGFR 30 - < 60 mL/min/1.73 m2 than those with eGFR >= 60 mL/min/1.73 m2.	Vitamin D	31-40	epidermal growth factor receptor	Homo sapiens	126-130
33745601-0	2021	The association of vitamin D levels and insulin resistance.	Vitamin D	19-28	insulin	Homo sapiens	40-47
33745601-2	2021	The latest studies indicate an inverse association between Vitamin D levels, insulin resistance, and Type 2 diabetes.	Vitamin D	59-68	insulin	Homo sapiens	77-84
33745601-3	2021	The objective of this study was to investigate the effect of vitamin D status on insulin resistance.	Vitamin D	61-70	insulin	Homo sapiens	81-88
33745601-11	2021	Both models showed a significant inverse relationship between Vitamin D levels and FPG and insulin levels, 2-h glucose and insulin levels, and HOMA2-IR.	Vitamin D	62-71	insulin	Homo sapiens	91-98
33745601-12	2021	The optimum cut point for vitamin D was calculated at about 25 nmol/L for preventing insulin resistance.	Vitamin D	26-35	insulin	Homo sapiens	85-92
33745601-13	2021	CONCLUSION: This study illustrated that there is a statistically significant inverse relationship between Vitamin D levels and insulin resistance.	Vitamin D	106-115	insulin	Homo sapiens	127-134
33434080-9	2021	Hence, along with other benefits, fortification of dairy products with vitamin D may be an effective approach to improve some cardiometabolic indicators, such as insulin resistance.	Vitamin D	71-80	insulin	Homo sapiens	162-169
33112413-9	2021	The levels of white blood cells, leukocytes subfamilies, and inflammatory parameters significantly correlated with vitamin D levels in both patients with and without diabetes (diabetic: p=0.012 for WBC, p=0.004 for NLR and p<0.001 for MLR and C-reactive protein, non-diabetic: p<0.001 for WBC; NLR, MLR and C reactive protein, respectively).	Vitamin D	115-124	C-reactive protein	Homo sapiens	243-261
33112413-9	2021	The levels of white blood cells, leukocytes subfamilies, and inflammatory parameters significantly correlated with vitamin D levels in both patients with and without diabetes (diabetic: p=0.012 for WBC, p=0.004 for NLR and p<0.001 for MLR and C-reactive protein, non-diabetic: p<0.001 for WBC; NLR, MLR and C reactive protein, respectively).	Vitamin D	115-124	C-reactive protein	Homo sapiens	307-325
33150518-10	2021	Relation among vitamin D and PTH through a natural year in children with obesity is partially known.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	29-32
33869246-10	2021	In addition, the restoration of vitamin D levels reestablished the amount of MCP1 and the renal expressions of CD68+ and CD3+ cells in the VDD+IRI+R rats.	Vitamin D	32-41	mast cell protease 1-like 1	Rattus norvegicus	77-81
33740066-0	2021	Association of alpha-1-antitrypsin deficiency with vitamin D status: who is most at risk of getting severe COVID-19?	Vitamin D	51-60	serpin family A member 1	Homo sapiens	15-34
33608491-4	2021	All three cells lines showed intracellular DBP, with increased expression and nuclear localisation of DBP in cells treated with the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D).	Vitamin D	147-156	D-box binding PAR bZIP transcription factor	Homo sapiens	102-105
33666884-8	2021	While all vitamin D-treated PBMCs showed reduced levels of IFN-gamma production, in vitro treatment of vitamin D showed no influence in IL-10 production.	Vitamin D	10-19	interferon gamma	Homo sapiens	59-68
32784045-9	2021	In conclusion, all the results reinforce the potential use of these vitamin D analogues as antitumor agents to treat HER2-positive and Triple Negative BC.	Vitamin D	68-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-121
33578174-0	2021	Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia.	Vitamin D	17-26	NLR family pyrin domain containing 1	Homo sapiens	62-67
33578174-0	2021	Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia.	Vitamin D	17-26	NLR family pyrin domain containing 3	Homo sapiens	68-73
33578174-0	2021	Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia.	Vitamin D	17-26	nuclear factor kappa B subunit 1	Homo sapiens	103-112
33578174-1	2021	This study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD) on NLRP1/NLRP3 inflammasomes and TLR4/NF-kappaB pathway in monocytes from pregnant women with preeclampsia (PE).	Vitamin D	77-86	NLR family pyrin domain containing 1	Homo sapiens	95-100
33578174-1	2021	This study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD) on NLRP1/NLRP3 inflammasomes and TLR4/NF-kappaB pathway in monocytes from pregnant women with preeclampsia (PE).	Vitamin D	77-86	NLR family pyrin domain containing 3	Homo sapiens	101-106
33842825-2	2021	Objective: To evaluate the effect of regular resistance training (Ex) with vitamin D (Vit.	Vitamin D	75-84	vitrin	Homo sapiens	86-89
33607405-4	2021	As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I"d believe that vitamin D binding protein (DBP) is maybe also involved.	Vitamin D	60-69	D-box binding PAR bZIP transcription factor	Homo sapiens	194-197
33607405-4	2021	As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I"d believe that vitamin D binding protein (DBP) is maybe also involved.	Vitamin D	98-107	D-box binding PAR bZIP transcription factor	Homo sapiens	194-197
33607405-5	2021	A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.	Vitamin D	66-75	D-box binding PAR bZIP transcription factor	Homo sapiens	17-20
33911937-11	2021	The positive alizarin red S staining, a higher expression of alkaline phosphatase, osteocalcin, and RunX2 confirmed the functional capability (osteogenic differentiation of the stem cells) of the released vitamin D.	Vitamin D	205-214	bone gamma-carboxyglutamate protein	Homo sapiens	83-94
33911937-11	2021	The positive alizarin red S staining, a higher expression of alkaline phosphatase, osteocalcin, and RunX2 confirmed the functional capability (osteogenic differentiation of the stem cells) of the released vitamin D.	Vitamin D	205-214	RUNX family transcription factor 2	Homo sapiens	100-105
33788001-7	2021	The vitamin D-deficient group had a significantly higher age and fibrinogen levels while also having a lower lymphocyte count compared to the insufficient and normal groups.	Vitamin D	4-13	fibrinogen beta chain	Homo sapiens	65-75
33788001-8	2021	The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = -0.496, p = <0.001), CRP (r = -0.309, p = 0.002) and fibrinogen levels (r = -0.381, p = <0.001).	Vitamin D	10-19	C-reactive protein	Homo sapiens	153-156
33788001-8	2021	The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = -0.496, p = <0.001), CRP (r = -0.309, p = 0.002) and fibrinogen levels (r = -0.381, p = <0.001).	Vitamin D	10-19	fibrinogen beta chain	Homo sapiens	185-195
33788001-9	2021	In a logistic regression analysis, vitamin D deficiency, D-dimer, and fibrinogen levels on admission were independent predictors of severe clinical course.Conclusion: This study revealed an association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric COVID-19 cases.	Vitamin D	210-219	fibrinogen beta chain	Homo sapiens	70-80
33898032-1	2021	Background: Estimation of parathyroid hormone (PTH) after thyroid surgery helps to predict the development of hypocalcemia and allows early intervention and management with oral calcium and/or vitamin D supplementation in the postoperative period.	Vitamin D	193-202	parathyroid hormone	Homo sapiens	26-45
33898032-1	2021	Background: Estimation of parathyroid hormone (PTH) after thyroid surgery helps to predict the development of hypocalcemia and allows early intervention and management with oral calcium and/or vitamin D supplementation in the postoperative period.	Vitamin D	193-202	parathyroid hormone	Homo sapiens	47-50
33898032-8	2021	Conclusion: PTH measurements at 3 h after total thyroidectomy is an accurate predictor for the development of hypocalcemia and allows starting early calcium and/or vitamin D supplements for the asymptotic patients with PTH level of less than 10 pg/ml, which is considered a high-risk group.	Vitamin D	164-173	parathyroid hormone	Homo sapiens	12-15
33719063-7	2022	While the vitamin D transportation role of DBP is well characterised in the liver and circulation, its function in alpha cells remain more enigmatic.	Vitamin D	10-19	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
33744225-2	2021	Therefore, the current research intended to study the impact of supplementation with vitamin D on insulin homeostasis among healthy obese and overweight individuals.	Vitamin D	85-94	insulin	Homo sapiens	98-105
33744225-9	2021	The patients who received vitamin D had significant lower levels of FBS (P < 0.001), fasting insulin (P < 0.001), HOMA2-IR (P < 0.001), and HOMA2-beta (P = 0.03), than the placebo group.	Vitamin D	26-35	insulin	Homo sapiens	93-100
33744225-12	2021	CONCLUSION: Supplementation with vitamin D improved sensitivity to insulin and pancreatic function of beta cells of healthy overweight and obese adults.	Vitamin D	33-42	insulin	Homo sapiens	67-74
33726658-14	2021	A significant negative correlation found between vitamin D and ALT (P= 0.02, -0.21) as well as vitamin D and CRP (P= 0.05, -0.17).	Vitamin D	95-104	C-reactive protein	Homo sapiens	109-112
33719063-8	2022	Recent work reveals that loss of DBP leads to smaller and hyperplastic alpha cells, which secrete less glucagon in response to low glucose concentration, despite vitamin D sufficiency.	Vitamin D	162-171	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
33704541-1	2021	The association between the risk of fractures and suboptimal vitamin D (Vit-D) status remains controversial in children.	Vitamin D	61-70	vitrin	Homo sapiens	72-75
33791128-2	2021	Vitamin D supplementation leads to reduced serum parathyroid hormone levels and improved cardiovascular markers.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	49-68
33438017-11	2021	Vitamin D metabolites have suppressive effects on the renin angiotensin system.	Vitamin D	0-9	renin	Homo sapiens	54-59
33777989-9	2021	Furthermore, the vitamin D status had significantly negative correlations with IL-6 (r = -0.56, P < 0.01) and TNF-alpha (r = -0.47, P < 0.01) levels.	Vitamin D	17-26	interleukin 6	Homo sapiens	79-83
33777989-9	2021	Furthermore, the vitamin D status had significantly negative correlations with IL-6 (r = -0.56, P < 0.01) and TNF-alpha (r = -0.47, P < 0.01) levels.	Vitamin D	17-26	tumor necrosis factor	Homo sapiens	110-119
33777989-11	2021	Severe vitamin D deficiency status may play a role in the painful DPN pathogenesis through elevated IL-6 and TNF-alpha levels.	Vitamin D	7-16	interleukin 6	Homo sapiens	100-104
33777989-11	2021	Severe vitamin D deficiency status may play a role in the painful DPN pathogenesis through elevated IL-6 and TNF-alpha levels.	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	109-118
33693593-5	2021	Vitamin D treatment also inhibits p-STAT3, Zeb1 and vimentin by 52%, 75% and 77% respectively, and increases E-cadherin by 87%.	Vitamin D	0-9	signal transducer and activator of transcription 3	Homo sapiens	36-41
33693593-5	2021	Vitamin D treatment also inhibits p-STAT3, Zeb1 and vimentin by 52%, 75% and 77% respectively, and increases E-cadherin by 87%.	Vitamin D	0-9	cadherin 1	Homo sapiens	109-119
33693593-6	2021	In vivo, dietary vitamin D deficiency maintains high levels of Zeb1 and p-STAT3 in cells from primary mammary tumors, and increases CXCL12 expression in lung stroma by 64%.	Vitamin D	17-26	signal transducer and activator of transcription 3	Homo sapiens	74-79
33535006-2	2021	To investigate the effects of 1,25-Vit D3 and 24,25-Vit D3 on corneal fibroblast expression of the vitamin D-associated enzymes CYP27B1 and CYP24A1 and the roles of the vitamin D receptor (VDR) and protein disulfide isomerase, family A, member 3 (Pdia3) in these cells.	Vitamin D	99-108	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	128-135
33535006-15	2021	1,25-Vit D3 modulates fibroblast vitamin D enzymes through both the VDR and Pdia3 pathways in a species-dependent manner.	Vitamin D	33-42	protein disulfide isomerase family A member 3	Homo sapiens	76-81
33658032-8	2021	Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement.	Vitamin D	23-32	CD4 molecule	Homo sapiens	168-171
33338606-0	2021	Double-counting of effect sizes and inappropriate exclusion of studies in "The influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis".	Vitamin D	92-101	insulin like growth factor 1	Homo sapiens	121-126
33541709-6	2021	Hub genes, such as amyloid beta precursor protein (APP), CDH2, SPP1, and STC2, were significantly associated with functions related to extracellular matrix organization and vitamin D response.	Vitamin D	173-182	amyloid beta precursor protein	Homo sapiens	19-49
33503443-10	2021	Thus, our primary goal via the current review to examine the impact of dietary vitamin D (VitD) in serum mediated risk reduction of insulin resistance and further incidence of DM through inflammatory liver associated high DBil.	Vitamin D	79-88	insulin	Homo sapiens	132-139
32955743-1	2021	CONTEXT: The monogenic disorder autoimmune polyendocrine syndrome type 1 (APS-1) or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) manifests frequently with hypoparathyroidism, which requires treatment with oral supplementation with calcium and active vitamin D analogs.	Vitamin D	277-286	autoimmune regulator	Homo sapiens	74-79
33557015-5	2021	Vitamin D and adipokines, such as leptin and adiponectin, are possible mediators connecting obesity and SLE.	Vitamin D	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	45-56
33197518-8	2021	These effects of vitamin D may be correlated with the PI3K/AKT/mTOR signaling pathway.	Vitamin D	17-26	AKT serine/threonine kinase 1	Homo sapiens	59-62
33197518-8	2021	These effects of vitamin D may be correlated with the PI3K/AKT/mTOR signaling pathway.	Vitamin D	17-26	mechanistic target of rapamycin kinase	Homo sapiens	63-67
33418034-9	2021	In vitro, the inflammatory response to TNFalpha was significantly reduced by calcipotriol in biliary cells silenced for VDR, and this effect was abolished by co-silencing the plasma membrane receptor of vitamin D, protein disulfide-isomerase A3 (PDIA3).	Vitamin D	203-212	tumor necrosis factor	Mus musculus	39-47
33640873-8	2021	Vitamin D suppressed PTH, while FGF23 was positively associated with PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	21-24
33026500-9	2021	Although the correlation between vitamin D and PTH was not statistically significant according to the Pearson correlation analysis, it was lower in the laryngomalacia group compared to the control group (p = 0.381, p > 0.05).	Vitamin D	33-42	parathyroid hormone	Homo sapiens	47-50
33655734-1	2021	Deficiency in vitamin D plays a role in the onset and development of insulin resistance (IR) and type 2 diabetes (T2DM).	Vitamin D	14-23	insulin	Homo sapiens	69-76
33655734-2	2021	A normal level of vitamin D is able to reduce low grade inflammation, which is a major process in inducing insulin resistance.	Vitamin D	18-27	insulin	Homo sapiens	107-114
33655734-4	2021	Vitamin D is also able to prevent hypermethylation (of DNA) and consequent functional inactivation of many genes, as well as other epigenetic alterations in beta cells and in other insulin-sensitive peripheral tissues, mainly liver, adipose tissue and muscle.	Vitamin D	0-9	insulin	Homo sapiens	181-188
33448317-5	2021	The present review discusses the possible synergistic action of OncoTherad with vitamin D, zinc and glutamine, nutrients that have been shown to facilitate immune responses mediated by IFN signaling, as well as the potential of this combination as a therapeutic option for COVID-19.	Vitamin D	80-89	interferon alpha 1	Homo sapiens	185-188
33746447-11	2021	While vitamin D-treated NAFLD group shows significant increased SMP-30 and decrease in HOMA-IR in comparison with nontreated NAFLD group.	Vitamin D	6-15	regucalcin	Rattus norvegicus	64-70
32770768-2	2021	The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
32770768-7	2021	The variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588.	Vitamin D	105-114	D-box binding PAR bZIP transcription factor	Homo sapiens	142-145
33594806-1	2021	AIM: An association between serum vitamin D (Vit D) levels and systemic lupus erythematosus (SLE) has been reported by several studies that suggested the involvement of genetically determined characteristics of enzymes of vitamin D metabolism.	Vitamin D	34-43	vitrin	Homo sapiens	45-48
33594806-1	2021	AIM: An association between serum vitamin D (Vit D) levels and systemic lupus erythematosus (SLE) has been reported by several studies that suggested the involvement of genetically determined characteristics of enzymes of vitamin D metabolism.	Vitamin D	222-231	vitrin	Homo sapiens	45-48
33594806-2	2021	Our study aimed to evaluate the relationship between 25 hydroxyvitamin D (25[OH]D) level, the most representative metabolite of VitD status, and polymorphism of the cytochrome P450, CYP27B1 gene, which influence vitamin D metabolism, and serum levels, in SLE Tunisian patients.	Vitamin D	63-72	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	182-189
33833974-2	2021	This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children.	Vitamin D	50-59	vitrin	Homo sapiens	61-64
33716989-10	2021	Vitamin D deficiency was associated with decreased CD80 and IFN-gamma in PCOS and IL-12 in both groups (p<0.05).	Vitamin D	0-9	interferon gamma	Homo sapiens	60-69
33672176-5	2021	In all subjects, vitamin D was negatively associated with c-reactive protein (CRP) (p < 0.001) and with probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque score (PI) (p < 0.001 for all parameters) and positively related to the number of teeth (p < 0.001).	Vitamin D	17-26	C-reactive protein	Homo sapiens	58-76
33672176-5	2021	In all subjects, vitamin D was negatively associated with c-reactive protein (CRP) (p < 0.001) and with probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque score (PI) (p < 0.001 for all parameters) and positively related to the number of teeth (p < 0.001).	Vitamin D	17-26	C-reactive protein	Homo sapiens	78-81
33672176-7	2021	The multivariate regression analysis showed that PT (p = 0.011) and CRP (p = 0.031) were both predictors of vitamin D levels.	Vitamin D	108-117	C-reactive protein	Homo sapiens	68-71
33671779-7	2021	Angiotensin II-induced contraction was pronounced in Vitamin D supplemented males.	Vitamin D	53-62	angiotensinogen	Rattus norvegicus	0-14
33669995-5	2021	Antioxidants, docosahexaenoic acid (DHA), and vitamin D, have potential for suppressing microglial production of interleukin-1beta, which potentiates the neurotoxicity of amyloid beta.	Vitamin D	46-55	interleukin 1 beta	Homo sapiens	113-130
33669995-5	2021	Antioxidants, docosahexaenoic acid (DHA), and vitamin D, have potential for suppressing microglial production of interleukin-1beta, which potentiates the neurotoxicity of amyloid beta.	Vitamin D	46-55	amyloid beta precursor protein	Homo sapiens	171-183
33602978-2	2021	This has been described in white and Asian population where low Vitamin D levels predicted future impairments in beta cell function and worsening of insulin resistance.	Vitamin D	64-73	insulin	Homo sapiens	149-156
33659272-0	2020	CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D.	Vitamin D	120-129	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-7
33659272-6	2020	Our findings reveal the underlying mechanism in which upregulation of CYP11A1 is detrimental to the physiological function of trophoblasts and demonstrate the beneficial effects of vitamin D supplementation in preventing placental and neurodevelopmental damage associated with CYP11A1 upregulation during pregnancy.	Vitamin D	181-190	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	277-284
33555325-0	2021	Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.	Vitamin D	6-15	insulin	Homo sapiens	58-65
33555325-2	2021	We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance.	Vitamin D	87-96	insulin	Homo sapiens	118-125
33555325-14	2021	CONCLUSIONS: MetS and insulin resistance are associated with lower vitamin D in patients with SLE.	Vitamin D	67-76	insulin	Homo sapiens	22-29
33036796-1	2021	OBJECTIVE: To study whether vitamin D (VitD) inhibits cell proliferation and Wnt/beta-catenin and transforming growth factor-beta (TGFbeta) signaling pathways in uterine leiomyomas independent of mediator complex subunit 12 (MED12) mutation status.	Vitamin D	28-37	tumor necrosis factor	Homo sapiens	98-129
33341448-5	2021	RESULTS: Across all tumour stages, vitamin D-deficient patients had the highest median levels of IL-6 (8.3 pg/mL, range 0.7-91), YKL-40 (177 ng/ml, range 25-5279) and CRP (15.5 mg/L, range 0.8-384).	Vitamin D	35-44	interleukin 6	Homo sapiens	97-101
33341448-5	2021	RESULTS: Across all tumour stages, vitamin D-deficient patients had the highest median levels of IL-6 (8.3 pg/mL, range 0.7-91), YKL-40 (177 ng/ml, range 25-5279) and CRP (15.5 mg/L, range 0.8-384).	Vitamin D	35-44	C-reactive protein	Homo sapiens	167-170
32931047-9	2021	The vitamin D activating enzyme CYP27B1 was markedly expressed in granuloma tissue and 1,25(OH)2 D3 was released in concentrations corresponding to 40-50% of the production by human kidney specimens.	Vitamin D	4-13	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	32-39
32275481-0	2021	Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients.	Vitamin D	15-24	serpin family A member 1	Homo sapiens	48-67
33058307-3	2021	METHODS: By using quantitative real-time polymerase chain reaction (qRT-PCR), we analyzed the expression ratio of CYP2R1, CYP27A1 and CYP27B1 genes within the vitamin D metabolic pathway in a total of 75 colorectal cancer (CRC) tissues compared to the adjacent tissues.	Vitamin D	159-168	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	134-141
33259938-9	2021	These data suggested that vitamin D/VDR could alleviate cisplatin-induced acute renal injury partly by inhibiting NF-kappaB-mediated NLRP3/Caspase-1/GSDMD pyroptosis.	Vitamin D	26-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
33428175-10	2021	In conclusion, our data indicate that concurrent vitamin D supplementation and ART, compared with monotherapy, successfully improve cardiac function and alleviate myocardial fibrosis via downregulating TGF-beta1, Smad2/3 signaling, and also regulating collagen I and III expressions.	Vitamin D	49-58	transforming growth factor, beta 1	Rattus norvegicus	202-211
33259938-9	2021	These data suggested that vitamin D/VDR could alleviate cisplatin-induced acute renal injury partly by inhibiting NF-kappaB-mediated NLRP3/Caspase-1/GSDMD pyroptosis.	Vitamin D	26-35	NLR family pyrin domain containing 3	Homo sapiens	133-138
33309619-8	2021	However, Vitamin D can significantly reverse the levels of TGF-beta1, Smad3 and p-smad3 caused by HRC in vitro.	Vitamin D	9-18	transforming growth factor beta 1	Homo sapiens	59-68
33508990-6	2021	Moreover, vitamin D intake led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (beta - 0.64 mg/L; 95% CI, -0.97, -0.30; p<.001) and a significant increase in total antioxidant capacity (TAC) (beta 47.54 mmol/L; 95% CI, 19.98, 75.11; p=.001) compared with the placebo.	Vitamin D	10-19	C-reactive protein	Homo sapiens	78-96
33508990-7	2021	CONCLUSIONS: Overall, our study demonstrated that vitamin D intake in patients with endometriosis resulted in a significant improvement of pelvic pain, total-/HDL-cholesterol ratio, hs-CRP and TAC levels, but did not affect other clinical symptoms and metabolic profiles.	Vitamin D	50-59	C-reactive protein	Homo sapiens	185-188
33504558-15	2021	TNF-alpha significantly and inversely associated with SBP in the presence of vitamin D insufficiency, fully adjusted model beta = -13.61 (95% CI -24.42 to -2.80); however, TNF-alpha was not associated with SBP in the absence of vitamin D insufficiency.	Vitamin D	77-86	tumor necrosis factor	Homo sapiens	0-9
33504558-15	2021	TNF-alpha significantly and inversely associated with SBP in the presence of vitamin D insufficiency, fully adjusted model beta = -13.61 (95% CI -24.42 to -2.80); however, TNF-alpha was not associated with SBP in the absence of vitamin D insufficiency.	Vitamin D	228-237	tumor necrosis factor	Homo sapiens	0-9
33492600-0	2021	New insights into vitamin D regulation: is there a role for alkaline phosphatase?	Vitamin D	18-27	alkaline phosphatase, placental	Homo sapiens	60-80
33479299-9	2021	Only PTH correlates always inversely with all six vitamin D compounds.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	5-8
33280041-10	2021	PTH was negatively associated with all vitamin D variables, with correlation coefficients ranging between -0.22 and -0.25; while calcium, and bone turnover markers (carboxy-terminal collagen crosslinks and osteocalcin) did not.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	0-3
33453021-14	2021	Subgroup analysis according to the intervention time showed that vitamin D intervention for more than 1 month significantly reduced PTH levels.	Vitamin D	65-74	parathyroid hormone	Homo sapiens	132-135
33536895-8	2020	Results: Gender, NIHSS, and FIB showed significant differences among the vitamin D groups (P < 0.001 ~ P = 0.002).	Vitamin D	73-82	fibrinogen beta chain	Homo sapiens	28-31
33536895-11	2020	Conclusions: The female gender, severity of stroke using NIHSS and FIB were risk factors for vitamin D deficiency in our incident stroke patients.	Vitamin D	93-102	fibrinogen beta chain	Homo sapiens	67-70
33536895-13	2020	Besides, under higher FIB circumstance, the increasing NIHSS score was more related to the vitamin D deficiency.	Vitamin D	91-100	fibrinogen beta chain	Homo sapiens	22-25
33677945-9	2021	25-OH-vitamin D deficiency was associated with increased CRP and dyspnea.	Vitamin D	6-15	C-reactive protein	Homo sapiens	57-60
33453021-17	2021	CONCLUSION: Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	107-110
33453021-17	2021	CONCLUSION: Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria.	Vitamin D	64-73	parathyroid hormone	Homo sapiens	107-110
33604214-1	2021	It is established that normal calcium and vitamin D concentrations are maintained in the body through parathyroid hormone (PTH), a signaling molecule secreted from parathyroid glands.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	102-121
33604214-1	2021	It is established that normal calcium and vitamin D concentrations are maintained in the body through parathyroid hormone (PTH), a signaling molecule secreted from parathyroid glands.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	123-126
33454206-8	2021	There was a negative correlation between vitamin D status and CRP levels (=-.364, p=.007).	Vitamin D	41-50	C-reactive protein	Homo sapiens	62-65
33435644-7	2021	Results from epidemiological, preclinical and some clinical studies demonstrated the link between thyroid, parathyroid hormone and vitamin D and cognitive status, between diabetes, and insulin resistance in particular, and dementia, between sexual and adrenal hormones, particularly estrogen variation at menopause, and cognitive decline.	Vitamin D	131-140	parathyroid hormone	Homo sapiens	107-126
33424968-7	2020	Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo.	Vitamin D	84-93	insulin	Homo sapiens	19-26
32613681-9	2021	Experimentally, vitamin D increases the ratio of angiotensin-converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.	Vitamin D	16-25	angiotensin I converting enzyme	Homo sapiens	82-85
32613681-9	2021	Experimentally, vitamin D increases the ratio of angiotensin-converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.	Vitamin D	16-25	angiotensinogen	Homo sapiens	112-126
33952739-10	2021	Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group.	Vitamin D	73-82	interleukin 6	Mus musculus	45-58
33952739-10	2021	Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group.	Vitamin D	73-82	interleukin 6	Mus musculus	60-64
33159979-0	2021	Vitamin D Exerts Neuroprotection via SIRT1/Nrf-2/ NF-kB Signaling Pathways against D-Galactose-induced Memory Impairment in Adult Mice.	Vitamin D	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-48
33406811-2	2021	Some studies suggest a relationship between vitamin D (Vit D) and calcium deficiency and the emergence of early dysmenorrhea.	Vitamin D	44-53	vitrin	Homo sapiens	55-58
33396784-1	2020	Background and objectives: Vitamin D is involved in insulin resistance through genomic and non-genomic mechanisms.	Vitamin D	27-36	insulin	Homo sapiens	52-59
33386179-6	2021	Overall, vitamin D supplementation significantly reduced serum fasting plasma glucose (FPG) (MD: -10.20 mg/dL, 95%CI: -13.43 to -6.96), insulin concentration (MD: -5.02 muIU/mL, 95%CI: -6.83 to -3.20) and the homeostasis model assessment of insulin resistance (HOMA-IR) (MD:-1.06, 95%CI: -1.40 to -0.72) in women with GDM.	Vitamin D	9-18	insulin	Homo sapiens	241-248
33197518-11	2021	The effect of vitamin D on NSCLC cells A549 and NCI-H1975 was correlated with the PI3K/AKT/mTOR signaling pathway.	Vitamin D	14-23	thymoma viral proto-oncogene 1	Mus musculus	87-90
33488605-6	2020	The production of anti-osteoclastogenic cytokines, e.g., IL-4 and IL-10, is promoted by IL-33 and vitamin D, which are stimulators of both regulatory and Th2 cells.	Vitamin D	98-107	interleukin 4	Homo sapiens	57-61
33458620-6	2021	Mechanistic validation demonstrated that vitamin D sufficiency promoted organoid growth and accelerated differentiation by inhibiting canonical Wnt activity and suppressing Wnt family member DKK3.	Vitamin D	41-50	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	191-195
33458620-7	2021	Wnt and DKK3 were also reduced by vitamin D in prostate tissue explants by spatial transcriptomics.	Vitamin D	34-43	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	8-12
33505780-1	2021	Background: Vitamin D 1alpha-hydroxylase CYP27B1 is the key factor in the vitamin D pathway.	Vitamin D	74-83	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	41-48
33408047-1	2021	BACKGROUND: Dietary agents, in particular vitamin D (Vit D) and selenium, are widely used by prostate cancer (PCa) patients to improve cancer outcomes.	Vitamin D	42-51	vitrin	Homo sapiens	53-56
32946038-3	2021	There is the clinical plausibility of the association between serum vitamin D (VIT D) content and viral respiratory infections.	Vitamin D	68-77	vitrin	Homo sapiens	79-82
33545754-8	2021	The pooled results demonstrated that vitamin D supplementation in patients with PCOS resulted in a significant improvement in serum total testosterone (TT), high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA).	Vitamin D	37-46	C-reactive protein	Homo sapiens	174-192
33545754-8	2021	The pooled results demonstrated that vitamin D supplementation in patients with PCOS resulted in a significant improvement in serum total testosterone (TT), high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA).	Vitamin D	37-46	C-reactive protein	Homo sapiens	197-200
33545754-10	2021	Subgroup analysis showed that vitamin D supplementation reduced hs-CRP and MDA irrespective of the treatment course, type of vitamin D intervention, supplementation frequency, and dosage.	Vitamin D	30-39	C-reactive protein	Homo sapiens	67-70
33545754-12	2021	CONCLUSIONS: The current meta-analysis demonstrates that vitamin D supplementation in patients with PCOS resulted in an improvement in the levels of TT, hs-CRP, TAC, and MDA, but did not affect FT, DHEA-S, SHBG, FAI, NO, and GSH levels.	Vitamin D	57-66	C-reactive protein	Homo sapiens	156-159
33545754-12	2021	CONCLUSIONS: The current meta-analysis demonstrates that vitamin D supplementation in patients with PCOS resulted in an improvement in the levels of TT, hs-CRP, TAC, and MDA, but did not affect FT, DHEA-S, SHBG, FAI, NO, and GSH levels.	Vitamin D	57-66	sex hormone binding globulin	Homo sapiens	206-210
32917645-3	2021	We tested the effects of supplemental vitamin D (1,000 I.U./day) and/or calcium (1,200 mg/day) on COX-2 and 15-HPGD expression in the morphologically-normal rectal mucosa from 62 colorectal adenoma patients in a placebo-controlled chemoprevention trial.	Vitamin D	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	98-103
32917645-6	2021	After 1 year of treatment, the mean COX-2/15-HPGD expression ratio in full-length crypts proportionately decreased 47% in the vitamin D group (P = 0.001), 46% in the calcium group (P = 0.002), and 34% in the calcium + vitamin D group (P = 0.03), relative to the placebo group.	Vitamin D	126-135	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
32917645-6	2021	After 1 year of treatment, the mean COX-2/15-HPGD expression ratio in full-length crypts proportionately decreased 47% in the vitamin D group (P = 0.001), 46% in the calcium group (P = 0.002), and 34% in the calcium + vitamin D group (P = 0.03), relative to the placebo group.	Vitamin D	218-227	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
32917645-7	2021	Among individuals with the functional vitamin D-binding protein isoform DBP2 (GC rs4588*A), the COX-2/15-HPDG ratio decreased 70% (P = 0.0006), 75% (P = 0.0002), and 60% (P = 0.006) in the vitamin D, calcium, and combined supplementation groups, respectively, relative to placebo.	Vitamin D	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-101
32917645-7	2021	Among individuals with the functional vitamin D-binding protein isoform DBP2 (GC rs4588*A), the COX-2/15-HPDG ratio decreased 70% (P = 0.0006), 75% (P = 0.0002), and 60% (P = 0.006) in the vitamin D, calcium, and combined supplementation groups, respectively, relative to placebo.	Vitamin D	189-198	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-101
32917645-8	2021	These results show that vitamin D and calcium favorably modulate the balance of expression of COX-2 and 15-HPGD-biomarkers of inflammation that are strongly linked to colorectal carcinogenesis-in the normal-appearing colorectal mucosa of colorectal adenoma patients (perhaps especially those with the DBP2 isoform).	Vitamin D	24-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	94-99
32416695-8	2021	Participants with adequate vitamin D were older in age, more obese and having lower eGFR (pvalues<0.05).	Vitamin D	27-36	epidermal growth factor receptor	Homo sapiens	84-88
33868609-8	2021	Furthermore, the ALT and AST levels were significantly improved in Vitamin D group compared to the placebo group (P<0.05).	Vitamin D	67-76	solute carrier family 17 member 5	Homo sapiens	25-28
33252081-2	2021	A possible relationship between vitamin D and APOE is not yet clear.	Vitamin D	32-41	apolipoprotein E	Homo sapiens	46-50
33252081-8	2021	Homozygous APOE 4 carriers also had significantly higher vitamin D levels (p = 0.009) compared to persons without the APOE 4 allele.	Vitamin D	57-66	apolipoprotein E	Homo sapiens	11-17
33001513-5	2021	In addition, the RNA expression of fibroblast growth factor 23, a bone-derived factor involved in the regulation of vitamin D metabolism, was significantly reduced with dietary P restriction.	Vitamin D	116-125	fibroblast growth factor 23	Ovis aries	35-62
32474936-6	2021	The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin.	Vitamin D	19-28	bone gamma-carboxyglutamate protein	Homo sapiens	132-143
33030563-15	2021	CONCLUSION: Treatment with MK-7 375 mug daily as an add-on to calcium and vitamin D increased carboxylation of osteocalcin.	Vitamin D	74-83	bone gamma-carboxyglutamate protein	Homo sapiens	111-122
33205696-10	2021	Moreover, in patients with vitamin D deficiency, the expression of TJ proteins (Occludin, claudin-1, ZO-1 and JAM-1) in the intestinal mucosa was reduced, and Treg cells in the peripheral blood were decreased, while Th17 cells were increased compared to those with vitamin D sufficiency and controls.	Vitamin D	27-36	tight junction protein 1	Homo sapiens	101-105
33372187-0	2020	Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders.	Vitamin D	0-9	solute carrier family 6 member 4	Homo sapiens	44-52
33372187-3	2020	Therefore, we investigate the hypothesis that serum vitamin D levels moderate the interaction between the serotonin transporter promotor gene polymorphism (5-HTTLPR) and childhood abuse in depressive disorders.	Vitamin D	52-61	solute carrier family 6 member 4	Homo sapiens	106-127
33372187-3	2020	Therefore, we investigate the hypothesis that serum vitamin D levels moderate the interaction between the serotonin transporter promotor gene polymorphism (5-HTTLPR) and childhood abuse in depressive disorders.	Vitamin D	52-61	solute carrier family 6 member 4	Homo sapiens	156-164
33302828-6	2021	Vitamin D deficiency is associated with enhanced pro-inflammatory state, increased formation of Abeta oligomers that might contribute to the cognitive decline typical of the elderly age and, perhaps, dementias.	Vitamin D	0-9	amyloid beta precursor protein	Homo sapiens	96-101
33457118-10	2020	Conclusions The correction of hypovitaminosis D in subjects with prediabetes led to improved insulin sensitivity as assessed by OGIS index at 120 minutes, signifying the role of vitamin D in glucose homeostasis.	Vitamin D	178-187	insulin	Homo sapiens	93-100
33362771-9	2020	Finally, in-depth analysis and literature mining revealed that Vitamin D binds with its receptor and could work through two different pathways: (i) it inhibits the expression of pro-inflammatory cytokines through blocking the TNF induced NFkB1 signaling pathway; and (ii) it initiates the expression of interferon-stimulating genes (ISGs) for antiviral defense program through activating the IFN-alpha induced Jak-STAT signaling pathway.	Vitamin D	63-72	tumor necrosis factor	Homo sapiens	226-229
33362771-9	2020	Finally, in-depth analysis and literature mining revealed that Vitamin D binds with its receptor and could work through two different pathways: (i) it inhibits the expression of pro-inflammatory cytokines through blocking the TNF induced NFkB1 signaling pathway; and (ii) it initiates the expression of interferon-stimulating genes (ISGs) for antiviral defense program through activating the IFN-alpha induced Jak-STAT signaling pathway.	Vitamin D	63-72	nuclear factor kappa B subunit 1	Homo sapiens	238-243
33362771-9	2020	Finally, in-depth analysis and literature mining revealed that Vitamin D binds with its receptor and could work through two different pathways: (i) it inhibits the expression of pro-inflammatory cytokines through blocking the TNF induced NFkB1 signaling pathway; and (ii) it initiates the expression of interferon-stimulating genes (ISGs) for antiviral defense program through activating the IFN-alpha induced Jak-STAT signaling pathway.	Vitamin D	63-72	interferon alpha 1	Homo sapiens	392-401
33362771-9	2020	Finally, in-depth analysis and literature mining revealed that Vitamin D binds with its receptor and could work through two different pathways: (i) it inhibits the expression of pro-inflammatory cytokines through blocking the TNF induced NFkB1 signaling pathway; and (ii) it initiates the expression of interferon-stimulating genes (ISGs) for antiviral defense program through activating the IFN-alpha induced Jak-STAT signaling pathway.	Vitamin D	63-72	stat	None	414-418
33506158-12	2021	Therefore, we determined our patient had ADH with a novel mutation of the CaSR gene and hypocalciuria resulting from a vitamin D deficiency.	Vitamin D	119-128	calcium sensing receptor	Homo sapiens	74-78
33365026-8	2020	Expression of IL-23A and vitamin D pathway genes VDR and CYP27B1 varied by HLA genotype and was lower in healthy individuals with high-risk HLA (p = 0.0025; p = 0.04), while healthy controls with low-risk HLA showed a stronger IL-10 and CD14 expression (p = 0.01; p = 0.03).	Vitamin D	25-34	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	57-64
33284035-3	2022	Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity.	Vitamin D	29-38	insulin	Homo sapiens	74-81
33284035-6	2022	Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality.	Vitamin D	29-38	insulin	Homo sapiens	78-85
33282605-8	2020	We also found a negative correlation between vitamin D level and TOS and catalase level.	Vitamin D	45-54	catalase	Homo sapiens	73-81
33273639-0	2020	Moderate to severe liver siderosis and raised AST are independent risk factors for vitamin D insufficiency in beta-thalassemia patients.	Vitamin D	83-92	solute carrier family 17 member 5	Homo sapiens	46-49
33962550-0	2021	Vitamin D in gestational diabetes mellitus and its association with hyperglycaemia, insulin sensitivity and other factors.	Vitamin D	0-9	insulin	Homo sapiens	84-91
33415000-10	2020	Taken together, our study revealed that vitamin D can inhibit caspase-3-mediated GSDME cleavage and thus reduce normal tissue pyroptosis, relieving chemotherapeutic side effects.	Vitamin D	40-49	caspase 3	Homo sapiens	62-71
33045433-0	2020	Insulin Sensitizing Effects of Vitamin D Repletion Mediated by Adipocyte Vitamin D Receptor: Studies in humans and mice.	Vitamin D	31-40	insulin	Homo sapiens	0-7
32996774-6	2020	For example, vitamin D suppresses the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response related to COVID-19.	Vitamin D	13-22	renin	Homo sapiens	53-58
32713029-8	2020	RESULTS: Compared with control participants, vitamin D deficiency women had significantly higher concentrations of fasting blood-glucose (P < 0.01), 1-h OGTT plasma glucose (P < 0.01), 2-h OGTT plasma glucose (P < 0.01), insulin (P < 0.01), HOMA-IR (P < 0.01), LDL (P < 0.01), and triglycerides (P = 0.02) and lower concentrations of HOMA-S (P < 0.01).	Vitamin D	45-54	insulin	Homo sapiens	221-228
33259013-4	2020	Cytochrome enzymes CYP27B1 and CYP24A1 that perform the final conversion of the circulating form of vitamin D, 25-hydroxyvitamin D (25-OHD) to the active VDR ligand, 1a,25-dihydroxyvitamin D and the catabolism of it to inactive 24,25-dihydroxyvitamin D, respectively, are also expressed in breast cancer tissues.	Vitamin D	100-109	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	19-26
33386179-6	2021	Overall, vitamin D supplementation significantly reduced serum fasting plasma glucose (FPG) (MD: -10.20 mg/dL, 95%CI: -13.43 to -6.96), insulin concentration (MD: -5.02 muIU/mL, 95%CI: -6.83 to -3.20) and the homeostasis model assessment of insulin resistance (HOMA-IR) (MD:-1.06, 95%CI: -1.40 to -0.72) in women with GDM.	Vitamin D	9-18	insulin	Homo sapiens	136-143
32649802-3	2020	This study was aimed at investigating whether prolactin excess determines the effect of vitamin D/selenomethionine combination therapy on thyroid autoimmunity.	Vitamin D	88-97	prolactin	Homo sapiens	46-55
32649802-10	2020	The decrease in antibody titres, as well as the improvement in vitamin D status, was more pronounced in subjects with prolactin levels within the reference range than in subjects with hyperprolactinaemia and was inversely correlated with prolactin levels.	Vitamin D	63-72	prolactin	Homo sapiens	118-127
32649802-10	2020	The decrease in antibody titres, as well as the improvement in vitamin D status, was more pronounced in subjects with prolactin levels within the reference range than in subjects with hyperprolactinaemia and was inversely correlated with prolactin levels.	Vitamin D	63-72	prolactin	Homo sapiens	189-198
33475596-0	2020	Frequency of Vitamin D deficiency and its association with serum PTH levels in end stage renal disease patients.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	65-68
33475596-1	2020	OBJECTIVE: To assess the frequency of Vitamin D Deficiency and its association with serum Parathormone (PTH) levels in End stage renal disease patients in a tertiary setup.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	90-102
33475596-1	2020	OBJECTIVE: To assess the frequency of Vitamin D Deficiency and its association with serum Parathormone (PTH) levels in End stage renal disease patients in a tertiary setup.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	104-107
33475596-6	2020	To determine association between Vitamin D and serum Parathormone (PTH) levels chi-square test was applied.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	53-65
33475596-6	2020	To determine association between Vitamin D and serum Parathormone (PTH) levels chi-square test was applied.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	67-70
33475596-15	2020	Both low and normal vitamin D was associated with High PTH (P <0.001) Other significant associations noted were that of High Alkaline Phosphatase with High PTH levels and a normal Vitamin D level (P<0.001).	Vitamin D	20-29	parathyroid hormone	Homo sapiens	55-58
33475596-16	2020	CONCLUSIONS: Our study revealed more than half of our participants were Vitamin D deficient and an association was found between Normal Vitamin D levels and high serum PTH levels with associated high alkaline phosphatase levels.	Vitamin D	136-145	parathyroid hormone	Homo sapiens	168-171
33045433-4	2020	METHODS: We examined the effects of repleting vitamin D in 25(OH)D-deficient, insulin resistant, overweight-to-obese human subjects (n=19).	Vitamin D	46-55	insulin	Homo sapiens	78-85
32616391-1	2020	AIM: To determine the association of vitamin D with insulin resistance and obesity in children.	Vitamin D	37-46	insulin	Homo sapiens	52-59
32617917-10	2020	There was a negative correlation between vitamin D and parathyroid hormone (r = - 0.235 p = 0.030).	Vitamin D	41-50	parathyroid hormone	Homo sapiens	55-74
32616391-8	2020	The rate of subjects with a vitamin D level of 20-30 ng/ml was significantly lower in the obese group than in the control group (p < 0.001) Within the obese group a statistically significant difference was determined between the insulin resistant and non-insulin resistant groups in respect of serum 25-hydroxyvitamin D levels (p = 0.001) and vitamin B12 levels (p = 0.001).	Vitamin D	28-37	insulin	Homo sapiens	229-236
32616391-8	2020	The rate of subjects with a vitamin D level of 20-30 ng/ml was significantly lower in the obese group than in the control group (p < 0.001) Within the obese group a statistically significant difference was determined between the insulin resistant and non-insulin resistant groups in respect of serum 25-hydroxyvitamin D levels (p = 0.001) and vitamin B12 levels (p = 0.001).	Vitamin D	28-37	insulin	Homo sapiens	255-262
33068383-7	2020	A negative relationship was present between serum sclerostin and 25-OH vitamin D levels.	Vitamin D	71-80	sclerostin	Homo sapiens	50-60
33331582-8	2020	Furthermore, the vitamin D deficient (<15 ng/ml) group showed a significantly higher plasma level of IL-6, IL-10, and IL-22 compared to the non-deficient (>=15 ng/ml) group.	Vitamin D	17-26	interleukin 6	Homo sapiens	101-105
33247367-11	2021	Multivariate linear regression models revealed a significant association of vitamin D insufficiency with WC and W/HtR (P < 0.05).	Vitamin D	76-85	telomerase RNA component	Homo sapiens	114-117
33247367-12	2021	Likewise, in the multivariate regression models, vitamin D deficiency was associated with BMI, WC, and W/HtR (P < 0.05).	Vitamin D	49-58	telomerase RNA component	Homo sapiens	105-108
33266022-8	2020	RESULTS: High-dose vitamin D treatment alone and combined with infliximab decreased the IL17A, IFNgamma and IL10 expression.	Vitamin D	19-28	interferon gamma	Homo sapiens	95-103
33266022-11	2020	CONCLUSIONS: High-dose vitamin D as monotherapy and combined with infliximab decreases IL17A, IFNgamma and IL-10 expression in mucosa within treatment groups.	Vitamin D	23-32	interferon gamma	Homo sapiens	94-102
33329754-0	2020	Molecular Analysis of CYP27B1 Mutations in Vitamin D-Dependent Rickets Type 1A: c.590G > A (p.G197D) Missense Mutation Causes a RNA Splicing Error.	Vitamin D	43-52	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	22-29
33329754-1	2020	Context: Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessively inherited disorder due to loss-of-function mutations in the CYP27B1 gene.	Vitamin D	9-18	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	146-153
33330279-14	2020	Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role.	Vitamin D	209-218	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	362-368
33329593-6	2020	Furthermore, analysis of CD46 expression on T cells from a cohort of patients with MS supplemented by vitamin D showed a negative correlation with the levels of circulating vitamin D.	Vitamin D	102-111	CD46 molecule	Homo sapiens	25-29
33329593-6	2020	Furthermore, analysis of CD46 expression on T cells from a cohort of patients with MS supplemented by vitamin D showed a negative correlation with the levels of circulating vitamin D.	Vitamin D	173-182	CD46 molecule	Homo sapiens	25-29
33329593-8	2020	Overall, our data show a crosstalk between vitamin D and CD46 that allows a preferential effect of Vitamin D on Tr1 cells, providing novel key insights into the role of an important modifiable environmental factor in MS.	Vitamin D	99-108	CD46 molecule	Homo sapiens	57-61
33097953-0	2020	An Expression of Concern from The Journal of Nutrition"s Editorial Office about: Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women.	Vitamin D	81-90	C-reactive protein	Homo sapiens	138-156
33097953-0	2020	An Expression of Concern from The Journal of Nutrition"s Editorial Office about: Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women.	Vitamin D	81-90	insulin	Homo sapiens	158-165
33097954-0	2020	An Expression of Concern from The Journal of Nutrition"s Editorial Office about: Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial.	Vitamin D	81-90	insulin	Homo sapiens	146-153
33330592-2	2020	Vitamin D deficiency can activate the parathyroid to induce the release of parathyroid hormone, which was thought to increase serum uric acid level, and low vitamin D status may also be associated with risk of CVD.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	75-94
33330279-14	2020	Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role.	Vitamin D	209-218	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	374-380
32391587-2	2020	However, it is unknown whether this association differs by the vitamin D-binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk.	Vitamin D	63-72	solute carrier family 25 member 18	Homo sapiens	102-105
33213116-6	2021	In fact, low vitamin D levels and severe obesity are significantly associated with some cardio-metabolic risk factors, including high body mass index, waist circumference, blood pressure, impaired lipid and glycemic profile, and insulin resistance, as they would seem associated with worse cardiovascular outcomes and higher cancer incidence and mortality.	Vitamin D	13-22	insulin	Homo sapiens	229-236
33184328-4	2020	Office DBP was also reduced after vitamin D supplementation.	Vitamin D	34-43	D-box binding PAR bZIP transcription factor	Homo sapiens	7-10
33216035-4	2021	Further, vitamin D promotes the expression of LRP1 and P-gp in AD-animal model brains.	Vitamin D	9-18	LDL receptor related protein 1	Homo sapiens	46-50
33184146-15	2022	CONCLUSION: Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation.	Vitamin D	34-43	fibrinogen beta chain	Homo sapiens	154-164
33244402-3	2020	Vitamin D metabolism includes 25-hydroxyvitamin D3 (25(OH)D3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), as the inactive and active form, with the help of 1alpha-hydroxylase (CYP27B1) enzyme.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	176-183
33224249-5	2020	Results: Vitamin D supplementation after the intervention led to a significant decrease in triglycerides (TG) (P = 0.02), very-low-density lipoprotein-cholesterol (VLDL-C) (P = 0.02), and hs-CRP (P = 0.03) concentrations and a significant increase in the serum vitamin D level (P < 0.001).	Vitamin D	9-18	C-reactive protein	Homo sapiens	191-194
33174974-0	2020	Vitamin D: association with eosinophil counts and IgE levels in children with asthma.	Vitamin D	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	50-53
33174974-1	2020	In this cross-sectional study, we investigated the relationship that levels of vitamin D had with eosinophil counts and IgE levels in 26 children with asthma (6-12 years of age) in the city of Londrina, Brazil.	Vitamin D	79-88	immunoglobulin heavy constant epsilon	Homo sapiens	120-123
33190990-0	2021	Blunted PTH response to vitamin D insufficiency/deficiency and colorectal neoplasia risk.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	8-11
33190990-2	2021	However, in previous studies, individuals with blunted parathyroid hormone (PTH) response to vitamin D insufficiency/deficiency (BPRVID), were not differentiated from those with high PTH response to vitamin D insufficiency/deficiency (HPRVID).	Vitamin D	93-102	parathyroid hormone	Homo sapiens	76-79
33038456-10	2020	The results of the multiple linear regression analysis indicate that vitamin D and HOMA are independent factors that significantly affect leptin and adiponectin levels, contrary to VAI.	Vitamin D	69-78	adiponectin, C1Q and collagen domain containing	Homo sapiens	149-160
32964520-1	2020	Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism.	Vitamin D	114-123	parathyroid hormone	Homo sapiens	40-59
32964520-1	2020	Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism.	Vitamin D	114-123	parathyroid hormone	Homo sapiens	61-64
33109593-8	2020	CONCLUSION: The significantly reduced activity of CYP27B1 in kidney from patients with ESRD explains the low level of circulating vitamin D.	Vitamin D	130-139	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	50-57
32820241-1	2020	Inadequate vitamin D nutritional status is prevalent worldwide and has been associated with autoimmune disorders, heart disease, deadly cancers, insulin resistance, inflammation, neurological disorders, adverse outcomes in pregnancy, and increased risk for mortality.	Vitamin D	11-20	insulin	Homo sapiens	145-152
32785694-1	2020	BACKGROUND: Elevated serum levels of parathyroid hormone (PTH), one of the main regulators of calcium homeostasis and vitamin D metabolism, have been proposed as predictors of mortality.	Vitamin D	118-127	parathyroid hormone	Homo sapiens	37-56
33037402-5	2020	Differential methylation of Vitamin D Receptor binding sites and MS risk genes was assessed from this and using pyrosequencing for the vitamin D regulated MS risk gene ZMIZ1.	Vitamin D	135-144	zinc finger MIZ-type containing 1	Homo sapiens	168-173
33037402-7	2020	Methylation of the vitamin D responsive MS risk gene ZMIZ1 was associated with risk SNP and disease.	Vitamin D	19-28	zinc finger MIZ-type containing 1	Homo sapiens	53-58
33182059-2	2020	IL-6 is known to be modulated by Vitamin D, and there is preliminary evidence that deficiency of this vitamin is linked to poorer outcomes.	Vitamin D	33-42	interleukin 6	Homo sapiens	0-4
33182059-5	2020	To determine whether Vitamin D may be beneficial at lowering IL-6 levels in patients, a limited analysis of trials examining the relationship between these entities published since 2015 was undertaken.	Vitamin D	21-30	interleukin 6	Homo sapiens	61-65
33182059-6	2020	Eight out of 11 studies described a significant lowering effect of Vitamin D on IL-6.	Vitamin D	67-76	interleukin 6	Homo sapiens	80-84
32970191-0	2020	[Hype about vitamin D substitution: what remains?]	Vitamin D	12-21	FIC domain protein adenylyltransferase	Homo sapiens	1-5
32970191-1	2020	The hype about vitamin D can be traced back to the ubiquitous presence of vitamin D receptors in many organ systems, in addition to the importance for healthy bones.	Vitamin D	15-24	FIC domain protein adenylyltransferase	Homo sapiens	4-8
32915988-0	2020	Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis.	Vitamin D	15-24	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	38-45
32915988-1	2020	BACKGROUND: Studies on organ-specific autoimmune endocrine disorders showed correlations between disease risks and vitamin D pathways gene variants, such as CYP27B1 rs10877012 and rs4646536, or CYP2R1 rs10741657 single nucleotide polymorphisms.	Vitamin D	115-124	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	157-164
33139636-1	2020	This study aims to verify the extent to which a diversification of carbohydrates and fats intake in a diet, together with the reduction in vitamin D deficiency, impact the levels of hormones (testosterone, estradiol, cortisol) and Sex Hormone Binding Globulin (SHGB) in men doing strength training.	Vitamin D	139-148	sex hormone binding globulin	Homo sapiens	231-259
32785694-1	2020	BACKGROUND: Elevated serum levels of parathyroid hormone (PTH), one of the main regulators of calcium homeostasis and vitamin D metabolism, have been proposed as predictors of mortality.	Vitamin D	118-127	parathyroid hormone	Homo sapiens	58-61
32785694-9	2020	The impact of PTH on mortality risk in patients with T2DM remained significant after adjustment for glycated hemoglobin A1c, diabetes duration, classical cardiovascular risk factors, serum levels of vitamin D, and kidney function (HR = 2.10 [1.10-4.10]; P = .030).	Vitamin D	199-208	parathyroid hormone	Homo sapiens	14-17
33341829-3	2020	The trend of vitamin D deficiency and frequency was assessed in relation to age, gender and serum levels of calcium, phosphorus, magnesium, alkaline phosphatase and parathyroid hormone.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	165-184
32737774-0	2020	Vitamin D attenuates HMGB1-mediated neointimal hyperplasia after percutaneous coronary intervention in swine.	Vitamin D	0-9	high mobility group protein B1	Sus scrofa	21-26
32769019-10	2020	Differential effects of 1,25(OH)2D3 on the expression of Il10 between control and obese mice suggest that regulation of immune response by vitamin D could be influenced by obesity.	Vitamin D	139-148	interleukin 10	Mus musculus	57-61
33254582-0	2020	Causing DNA damage and stopping DNA repair - Vitamin D supplementation with Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors may cause selective cell death of cancer cells: A novel therapeutic paradigm utilizing elevated copper levels within the tumour.	Vitamin D	45-54	poly(ADP-ribose) polymerase 1	Homo sapiens	76-105
33254582-0	2020	Causing DNA damage and stopping DNA repair - Vitamin D supplementation with Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors may cause selective cell death of cancer cells: A novel therapeutic paradigm utilizing elevated copper levels within the tumour.	Vitamin D	45-54	poly(ADP-ribose) polymerase 1	Homo sapiens	107-112
33254582-4	2020	In this communication we propose a Vitamin D supplementation strategy with PARP1 inhibitor treatment which would have multifaceted benefits for therapy.	Vitamin D	35-44	poly(ADP-ribose) polymerase 1	Homo sapiens	75-80
33254582-6	2020	Since Vitamin D is also a known inhibitor of PARP1, this therapeutic strategy would push the malignant cells to apoptosis due to DNA breakage via the vitamin D-copper mechanism, in addition to inhibiting DNA repair.	Vitamin D	6-15	poly(ADP-ribose) polymerase 1	Homo sapiens	45-50
33254582-6	2020	Since Vitamin D is also a known inhibitor of PARP1, this therapeutic strategy would push the malignant cells to apoptosis due to DNA breakage via the vitamin D-copper mechanism, in addition to inhibiting DNA repair.	Vitamin D	150-159	poly(ADP-ribose) polymerase 1	Homo sapiens	45-50
33289915-2	2020	The parathyroid hormone levels were in the lower normal range with highly elevated Vitamin D levels.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	4-23
32737774-4	2020	In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting.	Vitamin D	46-55	high mobility group protein B1	Sus scrofa	68-93
32737774-4	2020	In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting.	Vitamin D	46-55	high mobility group protein B1	Sus scrofa	95-100
32737774-11	2020	Vitamin D deficiency was associated with both increased in-stent restenosis and increased HMGB1-mediated inflammation noted in coronary arteries following intravascular stenting.	Vitamin D	0-9	high mobility group protein B1	Sus scrofa	90-95
32576302-9	2020	CONCLUSIONS: The results of the present study provide epidemiological evidence that vitamin D deficiency is associated with liver ALP levels in humans.	Vitamin D	84-93	alkaline phosphatase, placental	Homo sapiens	130-133
32579313-9	2020	CONCLUSIONS: Taking into account the lower 25(OH)D, 1,25(OH)D and Ca concentrations in the majority of centenarians, as well as the negative correlation between the vitamin D active metabolites and PTH, vitamin D and calcium supplementation should be systematically administered to the oldest of the elderly.	Vitamin D	165-174	parathyroid hormone	Homo sapiens	198-201
33021858-8	2020	Besides, vitamin D levels were correlated with the changes of bilirubin, albumin (ALB) and APRI (p<.05).	Vitamin D	9-18	albumin	Homo sapiens	73-80
33021858-8	2020	Besides, vitamin D levels were correlated with the changes of bilirubin, albumin (ALB) and APRI (p<.05).	Vitamin D	9-18	albumin	Homo sapiens	82-85
33021858-9	2020	PBC patients with vitamin D deficiency had higher bilirubin levels and lower ALB levels (p<.05).	Vitamin D	18-27	albumin	Homo sapiens	77-80
33064344-6	2021	Transgenic expression of cyp24a1 or a dominant-negative vitamin D receptor (VDR) inhibited regeneration of amputated fins, whereas global vitamin D treatment accelerated regeneration.	Vitamin D	56-65	vitamin D receptor a	Danio rerio	76-79
33109180-2	2020	In human research, the parathyroid hormone concentration in relation to the 25-hydroxyvitamin D concentration is used to determine vitamin D deficiency.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	23-42
33107041-12	2021	Therefore, the mRNA levels of MCP-1 and IL-8 in hPDLCs were significantly decreased through the vitamin D pathway.	Vitamin D	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
33107041-13	2021	CONCLUSION: The vitamin D pathway from vitamin D3 to hCAP-18/LL-37 exists in hPDLCs, and CYP27A1 might be involved in periodontal immune defense.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	53-60
33107041-13	2021	CONCLUSION: The vitamin D pathway from vitamin D3 to hCAP-18/LL-37 exists in hPDLCs, and CYP27A1 might be involved in periodontal immune defense.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	61-66
33154683-8	2020	There was a positive relationship between 25-(OH) D levels with temperature and solar radiation; however, parathyroid hormone, female and AQI were negatively correlated with Vitamin D levels.	Vitamin D	174-183	parathyroid hormone	Homo sapiens	106-125
33126575-5	2020	Vitamin D is a molecule with extensive anti-fibrotic, anti-inflammatory, and insulin-sensitizing properties, which have been proven also in hepatic cells and is involved in immune-metabolic pathways within the gut-adipose tissue-liver axis.	Vitamin D	0-9	insulin	Homo sapiens	77-84
33114615-13	2020	Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002).	Vitamin D	34-43	parathyroid hormone	Homo sapiens	134-153
33463118-8	2020	Vitamin D Intervention significantly (p<0.05) could increase the expression of Foxp3, IL-10, and TGF-beta1 gene in the CD4+ T cells of mice comparing with the control group.	Vitamin D	0-9	interleukin 10	Mus musculus	86-91
33064344-7	2021	Using tissue regeneration enhancer elements, we found that local enhancement of VDR expression could improve regeneration with low doses of a vitamin D analog.	Vitamin D	142-151	vitamin D receptor a	Danio rerio	80-83
33132636-4	2020	It is known that VDR can interact with other ligands such as bile acids in addition to vitamin D, and its expression can be induced by fatty acids, and insulin.	Vitamin D	87-96	insulin	Homo sapiens	152-159
32755551-0	2020	Vitamin D inhibits Tissue Factor and CAMs expression in oxidized low-density lipoproteins-treated human endothelial cells by modulating NF-kappaB pathway.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	136-145
33066259-6	2020	Epidemiological studies indicated that low circulating vitamin D levels inversely correlate with cutaneous manifestations and bone abnormalities, clinical hallmarks of neurofibromatosis type 1 (NF1).	Vitamin D	55-64	neurofibromin 1	Homo sapiens	194-197
33066259-8	2020	In this context, vitamin D or its analogues have been used to treat both skin and bone lesions in NF1 patients, alone or combined with other therapeutic agents.	Vitamin D	17-26	neurofibromin 1	Homo sapiens	98-101
33066259-9	2020	Here we provide an overview of vitamin D, its characteristic nutritional properties relevant for health benefits and its role in NF1 disorder.	Vitamin D	31-40	neurofibromin 1	Homo sapiens	129-132
33066259-10	2020	We focus on preclinical and clinical studies that demonstrated the clinical correlation between vitamin D status and NF1 disease, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy.	Vitamin D	96-105	neurofibromin 1	Homo sapiens	117-120
33060436-9	2021	Inflammatory markers, for example, erythrocyte sedimentation rate, C-reactive protein, and fecal calprotectin and interleukin-2 IL-12, IL-17, IL-23, and tumor necrosis factor-alpha significantly decreased in the vitamin D group.	Vitamin D	212-221	tumor necrosis factor	Homo sapiens	153-180
33066259-6	2020	Epidemiological studies indicated that low circulating vitamin D levels inversely correlate with cutaneous manifestations and bone abnormalities, clinical hallmarks of neurofibromatosis type 1 (NF1).	Vitamin D	55-64	neurofibromin 1	Homo sapiens	168-192
32736832-7	2020	Besides, vitamin D suppresses the compensatory increase in renin levels following the inhibition of the renin-angiotensin system by AT1R antagonists.	Vitamin D	9-18	renin	Homo sapiens	59-64
33066266-2	2020	We aimed to characterize the possible influence of vitamin D status on changes in expression of tissue transglutaminase gene (TGM2) and other genes involved in inflammatory response and autophagy in peripheral blood mononuclear cells (PBMC) from HIV+ subjects.	Vitamin D	51-60	transglutaminase 2	Homo sapiens	96-119
33066266-2	2020	We aimed to characterize the possible influence of vitamin D status on changes in expression of tissue transglutaminase gene (TGM2) and other genes involved in inflammatory response and autophagy in peripheral blood mononuclear cells (PBMC) from HIV+ subjects.	Vitamin D	51-60	transglutaminase 2	Homo sapiens	126-130
33030073-4	2020	According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk.	Vitamin D	36-45	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	80-84
32736832-7	2020	Besides, vitamin D suppresses the compensatory increase in renin levels following the inhibition of the renin-angiotensin system by AT1R antagonists.	Vitamin D	9-18	renin	Homo sapiens	104-109
31874050-0	2020	Effect of high dose vitamin D supplementation in combination with weight loss diet on Glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency: a double blind placebo-controlled randomized clinical trial.	Vitamin D	20-29	insulin	Homo sapiens	107-114
31874050-1	2020	As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency.	Vitamin D	67-76	insulin	Homo sapiens	80-87
31874050-1	2020	As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency.	Vitamin D	172-181	insulin	Homo sapiens	222-229
31874050-6	2020	Serum levels of 25(OH) D3 increased significantly with a simultaneous decrease in serum concentration of PTH in vitamin D group.	Vitamin D	112-121	parathyroid hormone	Homo sapiens	105-108
33717511-8	2020	started with the early stage of diseases (RRMS) we found that catalase activity, an enzyme that act as anti-oxidant, is significantly decreased compare with healthy people, and can be associated with a low level of vitamin D.	Vitamin D	215-224	catalase	Homo sapiens	62-70
33270596-12	2020	According to received results, the parental awareness and level of knowledge about vit D importance for child normal growth and health is poor.Sothere is a need for increased levels of parental education to ensure children have a better chance of maintaining adequate vitamin D levels.	Vitamin D	268-277	vitrin	Homo sapiens	83-86
32921000-7	2020	Participants with the highest tertile of vitamin D intake from food sources had decreased risk (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.54-0.97, P = .030) for dementia compared with those with the lowest tertile, adjusting for age, sex, race/ethnicity, education, apolipoprotein E (APOE)-epsilon4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease, and smoking.	Vitamin D	41-50	apolipoprotein E	Homo sapiens	279-295
32921000-7	2020	Participants with the highest tertile of vitamin D intake from food sources had decreased risk (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.54-0.97, P = .030) for dementia compared with those with the lowest tertile, adjusting for age, sex, race/ethnicity, education, apolipoprotein E (APOE)-epsilon4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease, and smoking.	Vitamin D	41-50	apolipoprotein E	Homo sapiens	297-301
33456593-4	2020	Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells.	Vitamin D	40-49	vitrin	Homo sapiens	51-54
32266756-1	2020	BACKGROUND: The present study aimed to evaluate the association between dietary vitamin D intake and 10-year first fatal/nonfatal cardiovascular disease (CVD), conventional CVD risk factors and surrogate markers related to inflammation, coagulation, insulin resistance, liver and renal function.	Vitamin D	80-89	insulin	Homo sapiens	250-257
32721035-5	2020	These results provide evidence that TRPV1 is a novel receptor for the biological actions of vitamin D in addition to the well-documented effects of vitamin D upon the nuclear vitamin D receptor.	Vitamin D	92-101	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	36-41
32721035-8	2020	As vitamin D is lipophilic and involved in similar biological processes as TRPV1, we hypothesized that it directly regulates TRPV1 activity and function.	Vitamin D	3-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-80
32721035-8	2020	As vitamin D is lipophilic and involved in similar biological processes as TRPV1, we hypothesized that it directly regulates TRPV1 activity and function.	Vitamin D	3-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	125-130
32721035-9	2020	Our calcium imaging and electrophysiological data demonstrate that vitamin D (25OHD and 1,25OHD) can weakly activate TRPV1 at physiologically relevant concentrations (100 nM).	Vitamin D	67-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	117-122
32721035-15	2020	In summary, we provide evidence that vitamin D is a novel endogenous regulator of TRPV1 channel activity that may play an important physiological role in addition to its known effects through the canonical nuclear vitamin D receptor pathway.	Vitamin D	37-46	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	82-87
32681429-0	2020	Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer.	Vitamin D	86-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-37
33004071-1	2020	OBJECTIVE: Vitamin D-dependent rickets type IA (VDDR-IA) is a rare autosomal recessive disorder characterized by the early onset of severe rickets.	Vitamin D	11-20	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	48-52
32659681-3	2020	The aim of this study was to examine the genetic associations between vitamins D, E, and B12 and five cancers (i.e., colorectal cancer, breast cancer, prostate cancer, malignant melanoma, and squamous cell carcinoma).	Vitamin D	70-80	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	89-92
32681429-4	2020	It is known that several androgen-metabolizing P450s (CYP3A4/5/43 and CYP2B6) and P450 enzymes (CYP2R1, CYP27A1, CYP27B1, CYP24A1, CYP3A4, CYP2J2), which are necessary for vitamin D metabolism, are expressed in the prostate.	Vitamin D	172-181	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60
33093965-8	2020	Results: There was a significant difference between the mean vitamin 25(OH)D (p = 0.001) and IL-8 levels (p = 0.002) before and after vitamin D supplementation.	Vitamin D	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
32739460-0	2020	The effect of moderate-intensity aerobic training on pulmonary function and estrogen receptor-alpha gene in postmenopausal women with vitamin D deficiency: A randomized control trial.	Vitamin D	134-143	estrogen receptor 1	Homo sapiens	76-99
32936248-7	2020	Incubation of human aortic smooth muscle cells with 1,25-dihyroxyvitamin D3 (the active metabolite of vitamin D) for 48 hours induced upregulation of sclerostin (P<0.001) and changed the expression of a range of other genes important in extracellular matrix remodeling.	Vitamin D	65-74	sclerostin	Homo sapiens	150-160
32936248-10	2020	These effects of vitamin D appeared to be mediated via changes in genes involved in extracellular matrix remodeling, particularly sclerostin.	Vitamin D	17-26	sclerostin	Homo sapiens	130-140
33093965-0	2020	Modulation of Interleukin-8 Production by Vitamin D Supplementation in Indonesian Patients with Diabetic Polyneuropathy: A Randomized Clinical Trial.	Vitamin D	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
32952100-9	2021	H-scores for VDR, Claudin-2 and E-cadherin were significantly lower in patients with vitamin D deficiency compared to patients with normal vitamin D level.	Vitamin D	85-94	claudin 2	Homo sapiens	18-27
33093965-1	2020	Objectives: We sought to assess the modulation of interleukin-8 (IL-8) production by vitamin D supplementation in Indonesian patients with diabetic polyneuropathy (DPN).	Vitamin D	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
33093965-1	2020	Objectives: We sought to assess the modulation of interleukin-8 (IL-8) production by vitamin D supplementation in Indonesian patients with diabetic polyneuropathy (DPN).	Vitamin D	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
32966467-8	2020	However, the pooled effect did not support that supplemental vitamin D was beneficial for concentrations of AST, TC, HDL-C and LDL-C.	Vitamin D	61-70	solute carrier family 17 member 5	Homo sapiens	108-111
32966467-9	2020	The present study provides substantial evidence that supplemental vitamin D has favorable effects on glycemic control and insulin sensitivity in NAFLD patients.	Vitamin D	66-75	insulin	Homo sapiens	122-129
33070539-7	2020	A possible sequence of events may be described as (1) angiotensin II converting enzyme-related initial endothelial injury followed by vitamin D receptor-related endothelial dysfunction, (2) endothelial lesions deteriorating to endothelialitis, coagulopathy and thrombosis, and (3) vascular damage exacerbating pulmonary pathology and making patients with vitamin D deficiency vulnerable to death.	Vitamin D	134-143	angiotensinogen	Homo sapiens	54-68
32976513-4	2020	After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage.	Vitamin D	85-94	C-reactive protein	Homo sapiens	179-197
32976513-4	2020	After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage.	Vitamin D	85-94	C-reactive protein	Homo sapiens	199-202
32976513-6	2020	The significant reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency also may help modulate the immune response possibly by reducing risk for cytokine storm in response to this viral infection.	Vitamin D	121-130	C-reactive protein	Homo sapiens	35-38
32972010-8	2020	Vitamin D in tissues or brain cells can also modulate calbindin-D28K, parvalbumin, and calretinin, and is involved in immune function, thanks also to the combination with curcumin.	Vitamin D	0-9	calbindin 2	Homo sapiens	87-97
32952100-9	2021	H-scores for VDR, Claudin-2 and E-cadherin were significantly lower in patients with vitamin D deficiency compared to patients with normal vitamin D level.	Vitamin D	85-94	cadherin 1	Homo sapiens	32-42
32952100-10	2021	There were positive correlations between 25-OH vitamin D level and H-scores for VDR, E-cadherin and Claudin-2 in patient group.	Vitamin D	47-56	cadherin 1	Homo sapiens	85-95
32952100-10	2021	There were positive correlations between 25-OH vitamin D level and H-scores for VDR, E-cadherin and Claudin-2 in patient group.	Vitamin D	47-56	claudin 2	Homo sapiens	100-109
32952100-13	2021	Furthermore, deficiency of vitamin D was related to decreased expression of VDR and epithelial barrier proteins E-cadherin and Claudin-2.	Vitamin D	27-36	cadherin 1	Homo sapiens	112-122
32952100-13	2021	Furthermore, deficiency of vitamin D was related to decreased expression of VDR and epithelial barrier proteins E-cadherin and Claudin-2.	Vitamin D	27-36	claudin 2	Homo sapiens	127-136
32984584-13	2020	Vitamin D diet significantly (p < 0.05) reduced the level of interleukin 1beta and TNF-alpha produced in the deficiency state.	Vitamin D	0-9	interleukin 1 beta	Rattus norvegicus	61-78
32947849-7	2020	Vitamin D level was significantly lower in breast cancer patients with estrogen receptor-negative or triple-negative subtypes than in those with other subtypes.	Vitamin D	0-9	estrogen receptor 1	Homo sapiens	71-88
32984584-13	2020	Vitamin D diet significantly (p < 0.05) reduced the level of interleukin 1beta and TNF-alpha produced in the deficiency state.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	83-92
32122880-6	2020	All six patients had high serum parathyroid hormone levels (median 45 pmol/L, range 27-120 pmol/L), a sensitive marker of total body calcium deprivation secondary to vitamin D deficiency.	Vitamin D	166-175	parathyroid hormone	Homo sapiens	32-51
32932945-11	2020	We suspect that increased supplementation of vitamin D should be based on albumin level and last until albumin levels are balanced.	Vitamin D	45-54	albumin	Homo sapiens	74-81
32932945-11	2020	We suspect that increased supplementation of vitamin D should be based on albumin level and last until albumin levels are balanced.	Vitamin D	45-54	albumin	Homo sapiens	103-110
32902017-15	2021	CONCLUSIONS: The rapid increase in Pax7 and VDR protein expression along with serum CK level after high-intensity exercise demonstrated an association between SMSC activity and activation of the vitamin D system in response to muscle injury in horses.	Vitamin D	195-204	paired box 7	Equus caballus	35-39
32902017-15	2021	CONCLUSIONS: The rapid increase in Pax7 and VDR protein expression along with serum CK level after high-intensity exercise demonstrated an association between SMSC activity and activation of the vitamin D system in response to muscle injury in horses.	Vitamin D	195-204	vitamin D receptor	Equus caballus	44-47
32899512-0	2020	Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region.	Vitamin D	46-55	renin binding protein	Homo sapiens	0-3
32673820-6	2020	RESULTS: The hBD-2 and LL-37 levels were higher in periodontitis compared to gingivitis patients within Vitamin D sufficient and deficient groups.	Vitamin D	104-113	defensin beta 4A	Homo sapiens	13-18
32673820-6	2020	RESULTS: The hBD-2 and LL-37 levels were higher in periodontitis compared to gingivitis patients within Vitamin D sufficient and deficient groups.	Vitamin D	104-113	cathelicidin antimicrobial peptide	Homo sapiens	23-28
32932777-0	2020	The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.	Vitamin D	34-43	insulin	Homo sapiens	53-60
32932777-1	2020	Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type 2 diabetes (T2DM).	Vitamin D	33-42	insulin	Homo sapiens	156-163
32932777-2	2020	While it is generally accepted that vitamin D is a regulator of bone homeostasis, its ability to counteract insulin resistance is subject to debate.	Vitamin D	36-45	insulin	Homo sapiens	108-115
32932777-3	2020	The goal of this communication is to review the molecular mechanism by which vitamin D reduces insulin resistance and related complications.	Vitamin D	77-86	insulin	Homo sapiens	95-102
32932777-8	2020	Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues.	Vitamin D	37-46	insulin	Homo sapiens	66-73
32932777-8	2020	Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues.	Vitamin D	37-46	insulin	Homo sapiens	156-163
32891139-2	2020	Vitamin D deficiency (VDD) is prevalent in obese children, and is hypothesized to cause insulin resistance and metabolic abnormalities.	Vitamin D	0-9	insulin	Homo sapiens	88-95
32517428-9	2020	The antenatal use of vitamin D containing supplements in non-insulin treated GDM patients might reduce the risk of CS and macrosomia.	Vitamin D	21-30	insulin	Homo sapiens	61-68
32429643-10	2020	Conclusion: Vitamin D deficiency may be a contributor to recurrent pregnancy loss and suggests that the supplementation of women with Vitamin D pre-pregnancy may be protective against URPL via affecting Tregs signature genes, FOXP3 and GITR.	Vitamin D	134-143	TNF receptor superfamily member 18	Homo sapiens	236-240
32622071-0	2020	Delta-like 1 (DLK1) is a possible mediator of vitamin D effects on bone and energy metabolism.	Vitamin D	46-55	delta like non-canonical Notch ligand 1	Homo sapiens	0-12
32622071-0	2020	Delta-like 1 (DLK1) is a possible mediator of vitamin D effects on bone and energy metabolism.	Vitamin D	46-55	delta like non-canonical Notch ligand 1	Homo sapiens	14-18
32622071-7	2020	Overall, there was a significant increase in serum DLK1 and leptin and a decrease in VCAM, but no change in CRP, after 12 months of vitamin D supplementation.	Vitamin D	132-141	delta like non-canonical Notch ligand 1	Homo sapiens	51-55
32622071-15	2020	However, further studies are needed to explore the role of DLK1 and its relationship to vitamin D metabolites in vivo.	Vitamin D	88-97	delta like non-canonical Notch ligand 1	Homo sapiens	59-63
32379895-12	2020	Studies examining the effect of vitamin D treatment on serum IGF-1 and IGFBP-3 have not been in agreement since different populations, dosages, and intervention periods have been used.	Vitamin D	32-41	insulin like growth factor 1	Homo sapiens	61-66
32913635-2	2020	The retention of phosphorus and the reductions in calcium and vitamin D levels stimulate the synthesis and secretion of parathyroid hormone as well as the proliferation rate of parathyroid cells.	Vitamin D	62-71	parathyroid hormone	None	120-139
32604067-10	2020	Vitamin D and 17beta-estradiol showed neuroprotective effects by decreasing OVX-induced apoptosis and neuronal damage, regulating the AMPK/NF-kappaB signaling pathway, and reducing the proinflammatory cytokines (IL-1beta, IL-6, and TNFalpha), as well as iNOS and COX-2 in the hippocampus of OVX rats.	Vitamin D	0-9	interleukin 1 alpha	Rattus norvegicus	212-220
32604067-10	2020	Vitamin D and 17beta-estradiol showed neuroprotective effects by decreasing OVX-induced apoptosis and neuronal damage, regulating the AMPK/NF-kappaB signaling pathway, and reducing the proinflammatory cytokines (IL-1beta, IL-6, and TNFalpha), as well as iNOS and COX-2 in the hippocampus of OVX rats.	Vitamin D	0-9	interleukin 6	Rattus norvegicus	222-226
32604067-10	2020	Vitamin D and 17beta-estradiol showed neuroprotective effects by decreasing OVX-induced apoptosis and neuronal damage, regulating the AMPK/NF-kappaB signaling pathway, and reducing the proinflammatory cytokines (IL-1beta, IL-6, and TNFalpha), as well as iNOS and COX-2 in the hippocampus of OVX rats.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	232-240
32604067-10	2020	Vitamin D and 17beta-estradiol showed neuroprotective effects by decreasing OVX-induced apoptosis and neuronal damage, regulating the AMPK/NF-kappaB signaling pathway, and reducing the proinflammatory cytokines (IL-1beta, IL-6, and TNFalpha), as well as iNOS and COX-2 in the hippocampus of OVX rats.	Vitamin D	0-9	nitric oxide synthase 2	Rattus norvegicus	254-258
32565249-2	2020	Interactions between VDR and a protein-disulfide isomerase-associated 3 (PDIA3) in the regulation of extracellular matrix have been reported and we aim to analyze the relevance of the VDR genotypes and the effects of Vitamin D (VD) in the expression of VDR, PDIA3 and proliferation of intestinal fibroblasts.	Vitamin D	217-226	protein disulfide isomerase family A member 3	Homo sapiens	73-78
32870735-6	2021	AMPs stimulate TLR2 in macrophages, increasing the conversion of vitamin D into its active form by cytochrome P450 27B1.	Vitamin D	65-74	toll like receptor 2	Homo sapiens	15-19
32870735-6	2021	AMPs stimulate TLR2 in macrophages, increasing the conversion of vitamin D into its active form by cytochrome P450 27B1.	Vitamin D	65-74	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	99-119
32306297-0	2020	Relationships Between Vitamin D Status and PTH over 5 Years After Roux-en-Y Gastric Bypass: a Longitudinal Cohort Study.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	43-46
32968400-8	2020	The mechanism may be associated with the impact of vitamin D deficiency on hs-CRP and other body inflammation indicators, as well as on thyroid autoantibodies and other immune indicators, but has no effect on IL-1 levels.	Vitamin D	51-60	C-reactive protein	Homo sapiens	78-81
32213215-0	2020	The role of PTH during pregnancy on the relationship between maternal vitamin D deficiency and foetal growth restriction: a prospective birth cohort study.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	12-15
32867201-7	2020	Our results showed that the combination of the two compounds is able to counteract the appearance of an adipogenic phenotype, indicating a feedforward regulation on vitamin D metabolism by metformin, acting on CYP27B1 and CYP3A4.	Vitamin D	165-174	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	210-217
32867201-7	2020	Our results showed that the combination of the two compounds is able to counteract the appearance of an adipogenic phenotype, indicating a feedforward regulation on vitamin D metabolism by metformin, acting on CYP27B1 and CYP3A4.	Vitamin D	165-174	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	222-228
32867053-3	2020	Serum vitamin D concentration influences the expression of airway surface liquid (ASL) antimicrobial peptides such as LL-37.	Vitamin D	6-15	cathelicidin antimicrobial peptide	Homo sapiens	118-123
32867053-13	2020	Supplementation of vitamin D during winter-spring restores ASL antimicrobial activity by increasing the expression of antimicrobial peptides including LL-37.	Vitamin D	19-28	cathelicidin antimicrobial peptide	Homo sapiens	151-156
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	0-9	interleukin 6	Homo sapiens	198-211
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	0-9	interleukin 6	Homo sapiens	213-217
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	224-245
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	247-250
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	100-109	interleukin 6	Homo sapiens	213-217
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	100-109	tumor necrosis factor	Homo sapiens	224-245
32847594-16	2020	Vitamin D might act as a strong immunosuppressant inhibiting cytokine release syndrome in COVID-19: Vitamin D: Suppression of key pro-inflammatory pathways including nuclear factor kappa B (NF-kB), interleukin-6 (IL-6), and tumor necrosis factor (TNF).	Vitamin D	100-109	tumor necrosis factor	Homo sapiens	247-250
32904593-2	2020	Here, we hypothesize that a single large dose of vitamin D (Vit D) could be an option for trial in COVID-19.	Vitamin D	49-58	vitrin	Homo sapiens	60-63
32824266-7	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3/calcitriol upregulated stemness-related genes (LGR5, LRIG1, SMOC2, and MSI1) in normal rectum organoids, while it downregulated differentiation marker genes (TFF2 and MUC2).	Vitamin D	11-20	trefoil factor 2	Homo sapiens	220-224
32824266-7	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3/calcitriol upregulated stemness-related genes (LGR5, LRIG1, SMOC2, and MSI1) in normal rectum organoids, while it downregulated differentiation marker genes (TFF2 and MUC2).	Vitamin D	11-20	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	229-233
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	dynamin 1-like	Mus musculus	165-190
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	dynamin 1-like	Mus musculus	192-196
32922301-12	2020	Primary prevention of coronavirus infection and TNF alpha release in response to it could be improved by induction of antimicrobial peptides LL-37 and human beta defensin-2 and reduction of TNF alpha production by vitamin D prophylaxis for the population as a whole.	Vitamin D	214-223	tumor necrosis factor	Homo sapiens	48-57
32922301-12	2020	Primary prevention of coronavirus infection and TNF alpha release in response to it could be improved by induction of antimicrobial peptides LL-37 and human beta defensin-2 and reduction of TNF alpha production by vitamin D prophylaxis for the population as a whole.	Vitamin D	214-223	tumor necrosis factor	Homo sapiens	190-199
32408752-9	2020	In multivariate analysis, only AIDS status and CRP level were correlated with vitamin D level (slope estimate = 11.6 and p = 0.032 and slope estimate = -0.83 and p = 0.002; respectively).	Vitamin D	78-87	C-reactive protein	Homo sapiens	47-50
32408752-10	2020	In summary, we report that low vitamin D level may be associated with high CRP level in HIV-infected patients on suppressive antiretroviral therapy, especially in AIDS phase.	Vitamin D	31-40	C-reactive protein	Homo sapiens	75-78
32413483-9	2020	The inhibitory or stimulatory effects of vitamin D on AGE receptors are mediated by various signaling pathways, MAPK/NF-kappaB, ADAM10/MMP9 and AT1R.	Vitamin D	41-50	nuclear factor kappa B subunit 1	Homo sapiens	117-126
32712621-0	2020	Vitamin D Attenuates Hypoxia-Induced Injury in Rat Primary Neuron Cells through Downregulation of the Dual Oxidase 1 (DUOX1) Gene.	Vitamin D	0-9	dual oxidase 1	Rattus norvegicus	102-116
32712621-0	2020	Vitamin D Attenuates Hypoxia-Induced Injury in Rat Primary Neuron Cells through Downregulation of the Dual Oxidase 1 (DUOX1) Gene.	Vitamin D	0-9	dual oxidase 1	Rattus norvegicus	118-123
32712621-13	2020	Vitamin D significantly counteracted the effects of DUOX1 overexpression induced injury in rat primary neuron cells.	Vitamin D	0-9	dual oxidase 1	Rattus norvegicus	52-57
32712621-14	2020	CONCLUSIONS Our study indicated that vitamin D may protect neuron cells from hypoxia-induced injury by regulating DUOX1 via the NF-kappaB signaling pathway.	Vitamin D	37-46	dual oxidase 1	Rattus norvegicus	114-119
32717896-9	2020	Cytochrome P450 3A4 (CYP3A4) is the primary hepatic enzyme along with P-glycoprotein involved in the disposition of the vitamin D derivatives.	Vitamin D	120-129	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-19
32717896-9	2020	Cytochrome P450 3A4 (CYP3A4) is the primary hepatic enzyme along with P-glycoprotein involved in the disposition of the vitamin D derivatives.	Vitamin D	120-129	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27
32540991-2	2020	The major circulating metabolite of vitamin D (25-hydroxyvitamin D) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1 In multiple sclerosis lesions, the tyrosine kinase MerTK expressed by myeloid cells regulates phagocytosis of myelin debris and apoptotic cells that can accumulate and inhibit tissue repair and remyelination.	Vitamin D	36-45	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	139-146
32603782-0	2020	Vitamin D modulates E-cadherin turnover by regulating TGF-beta and Wnt signalings during EMT-mediated myofibroblast differentiation in A459 cells.	Vitamin D	0-9	cadherin 1	Homo sapiens	20-30
32705172-0	2020	Vitamin D protects against necrotising enterocolitis in newborn mice by activating the ERK signalling pathway.	Vitamin D	0-9	mitogen-activated protein kinase 1	Mus musculus	87-90
32705172-8	2020	In NEC mice, vitamin D reduced intestinal tissue damage, decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha, and decreased the protein expression of cleaved caspase-3 and MDA.	Vitamin D	13-22	interleukin 6	Mus musculus	90-94
32705172-8	2020	In NEC mice, vitamin D reduced intestinal tissue damage, decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha, and decreased the protein expression of cleaved caspase-3 and MDA.	Vitamin D	13-22	tumor necrosis factor	Mus musculus	109-118
32705172-9	2020	Whereas, vitamin D increased the protein expression of Bcl-2 and Ki67 and GPx, as well as the p-ERK1/2/ERK1/2 ratio, in NEC mice.	Vitamin D	9-18	B cell leukemia/lymphoma 2	Mus musculus	55-60
32705172-10	2020	Furthermore, vitamin D improved cell viability, increased the ratio of p-ERK1/2/ERK1/2, inhibited apoptosis, and decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha in LPS-treated IEC-6 cells.	Vitamin D	13-22	interleukin 6	Rattus norvegicus	146-150
32705172-10	2020	Furthermore, vitamin D improved cell viability, increased the ratio of p-ERK1/2/ERK1/2, inhibited apoptosis, and decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha in LPS-treated IEC-6 cells.	Vitamin D	13-22	interleukin 1 alpha	Rattus norvegicus	152-160
32705172-10	2020	Furthermore, vitamin D improved cell viability, increased the ratio of p-ERK1/2/ERK1/2, inhibited apoptosis, and decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha in LPS-treated IEC-6 cells.	Vitamin D	13-22	tumor necrosis factor	Rattus norvegicus	165-174
32705172-13	2020	Vitamin D promoted proliferation, and inhibited apoptosis and inflammation of LPS-treated IEC-6 cells by activating the ERK signalling pathway.	Vitamin D	0-9	Eph receptor B1	Rattus norvegicus	120-123
32584474-4	2020	Vitamin D, a fat-soluble-vitamin, is a negative endocrine RAS modulator and inhibits renin expression and generation.	Vitamin D	0-9	renin	Homo sapiens	85-90
32485309-0	2020	Vitamin D reduces autophagy by regulating NF-kappaB resistance to Aspergillus fumigatus infection.	Vitamin D	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
32485309-15	2020	In the RAW264.7 cells, Lentivirus transfection and SiRNA technologies were used to enhance or reduce the expression of the NF-kappaB gene (siNF-kappaB) for investgating the influence of high or low expression of NF-kappaB in the autophagic flow of vitamin D + or vitamin D-treated RAW264.7 cells.	Vitamin D	248-257	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
32485309-15	2020	In the RAW264.7 cells, Lentivirus transfection and SiRNA technologies were used to enhance or reduce the expression of the NF-kappaB gene (siNF-kappaB) for investgating the influence of high or low expression of NF-kappaB in the autophagic flow of vitamin D + or vitamin D-treated RAW264.7 cells.	Vitamin D	263-272	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
32485309-17	2020	In vitro cell experiments, when cell was stimulated with vitamin D, the expressions of NF-kappaB and IL-8 in cells were lower.	Vitamin D	57-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
32485309-18	2020	The autophagic flux and TNF-alpha, IL-1beta, IL-6 and LC3BII in vitamin D group were significantly lower than those in vitamin D deficiency group.	Vitamin D	64-73	tumor necrosis factor	Mus musculus	24-33
32485309-18	2020	The autophagic flux and TNF-alpha, IL-1beta, IL-6 and LC3BII in vitamin D group were significantly lower than those in vitamin D deficiency group.	Vitamin D	64-73	interleukin 6	Mus musculus	45-49
32485309-20	2020	When the body is sufficient in vitamin D, if the lungs infect Aspergillus fumigatus spores, the body may resist the infection of Aspergillus fumigatus by reducing the expression of NF-kappaB, inflammatory factors and autophagy.	Vitamin D	31-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
32842513-8	2020	Level 1 and 2 evidence supports the use of thiamine, vitamin C, and vitamin D in COVID-like respiratory diseases, ARDS, and sepsis.	Vitamin D	68-77	level 1 and 2	None	0-13
32821633-0	2020	Response of Parathyroid Hormone to Vitamin D Deficiency in Otherwise Healthy Individuals.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	12-31
32821633-5	2020	The objective of this study is to assess deficiency of vitamin D in otherwise healthy individuals, and to determine the response of the PTH to vitamin D deficiency.	Vitamin D	143-152	parathyroid hormone	Homo sapiens	136-139
32408752-5	2020	In HIV-infected group, a significant positive correlation between CD4+ cell percentage and vitamin D level was observed (r=0.17; p=0.036).	Vitamin D	91-100	CD4 molecule	Homo sapiens	66-69
32408752-6	2020	Furthermore, the significant negative correlation between vitamin D level and CD8+ cell percentage, PLT, CRP and D-dimers was seen.	Vitamin D	58-67	C-reactive protein	Homo sapiens	105-108
32469401-9	2020	Further studies are needed to determine whether differences in the vitamin D-PTH endocrine system contribute to racial disparities in cardiovascular health.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	77-80
32737345-6	2020	In these 299 patients, vitamin D supplementation had significant favorable effects on Diastolic Blood Pressure (DBP) (- 2.96, p = 0.02) and Parathyroid hormone (PTH) (- 4.05, p < 0.001).	Vitamin D	23-32	parathyroid hormone	Homo sapiens	140-159
32737345-6	2020	In these 299 patients, vitamin D supplementation had significant favorable effects on Diastolic Blood Pressure (DBP) (- 2.96, p = 0.02) and Parathyroid hormone (PTH) (- 4.05, p < 0.001).	Vitamin D	23-32	parathyroid hormone	Homo sapiens	161-164
32699341-6	2020	Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfalpha-deficient mice.	Vitamin D	66-75	tumor necrosis factor	Mus musculus	112-120
32684140-1	2022	Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored.	Vitamin D	35-44	iodothyronine deiodinase 3	Homo sapiens	70-72
32684941-0	2020	Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein.	Vitamin D	0-9	C-reactive protein	Homo sapiens	85-103
32684941-2	2020	Objective: The objective of this study was to evaluate the role of vitamin D status on the relationship between lipid profile and high-sensitivity C-reactive protein (hs-CRP) in pregnant women.	Vitamin D	67-76	C-reactive protein	Homo sapiens	147-165
32684941-2	2020	Objective: The objective of this study was to evaluate the role of vitamin D status on the relationship between lipid profile and high-sensitivity C-reactive protein (hs-CRP) in pregnant women.	Vitamin D	67-76	C-reactive protein	Homo sapiens	170-173
32684941-11	2020	Conclusion: Our findings suggest that high levels of vitamin D during pregnancy may improve lipid profile levels and inhibit elevated hs-CRP induced by high lipid metabolism.	Vitamin D	53-62	C-reactive protein	Homo sapiens	137-140
32639223-2	2021	Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue.	Vitamin D	33-42	insulin	Homo sapiens	73-80
32659891-6	2020	RESULTS: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-alpha concentrations (p < 0.0001) compared to placebo.	Vitamin D	13-22	C-reactive protein	Homo sapiens	118-121
32659891-6	2020	RESULTS: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-alpha concentrations (p < 0.0001) compared to placebo.	Vitamin D	13-22	tumor necrosis factor	Homo sapiens	126-135
32884931-2	2020	Vitamin D deficiency and insufficiency has recently been recognized as a contributing factor to the pathogenesis of GDM, and this link might be associated with hyperglycemia, insulin resistance, and inflammation, which are implicated in GDM.	Vitamin D	0-9	insulin	Homo sapiens	175-182
32884931-3	2020	Objectives: This study aims at investigating the relationship between vitamin D, fasting plasma glucose (FPG), insulin, zinc, ferritin, and high-sensitivity C-reactive protein (CRP) in GDM.	Vitamin D	70-79	C-reactive protein	Homo sapiens	157-175
32884931-3	2020	Objectives: This study aims at investigating the relationship between vitamin D, fasting plasma glucose (FPG), insulin, zinc, ferritin, and high-sensitivity C-reactive protein (CRP) in GDM.	Vitamin D	70-79	C-reactive protein	Homo sapiens	177-180
32884931-8	2020	In the GDM group, a positive weak relationship was observed between vitamin D and zinc (r = 0.18, p < 0.05), while vitamin D was inversely correlated with FPG, serum insulin, ferritin, and CRP (r = -0.23, -0.21, -0.20, -0.46, respectively, p < 0.05).	Vitamin D	115-124	insulin	Homo sapiens	166-173
32884931-8	2020	In the GDM group, a positive weak relationship was observed between vitamin D and zinc (r = 0.18, p < 0.05), while vitamin D was inversely correlated with FPG, serum insulin, ferritin, and CRP (r = -0.23, -0.21, -0.20, -0.46, respectively, p < 0.05).	Vitamin D	115-124	C-reactive protein	Homo sapiens	189-192
32775008-0	2020	Variants in SNAI1, AMDHD1 and CUBN in vitamin D pathway genes are associated with breast cancer risk: a large-scale analysis of 14 GWASs in the DRIVE study.	Vitamin D	38-47	snail family transcriptional repressor 1	Homo sapiens	12-17
32453393-0	2020	Supplementation with vitamin D or omega-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial.	Vitamin D	21-30	sarcoma antigen 1	Homo sapiens	110-114
32277536-6	2020	The percentage of IFN-gamma- or TNF-alpha-producing Th cells was significantly increased in VDI or vitamin D deficiency group (VDD) when compared with VDN (P < 0.05 each).	Vitamin D	99-108	interferon gamma	Homo sapiens	18-27
32277536-6	2020	The percentage of IFN-gamma- or TNF-alpha-producing Th cells was significantly increased in VDI or vitamin D deficiency group (VDD) when compared with VDN (P < 0.05 each).	Vitamin D	99-108	tumor necrosis factor	Homo sapiens	32-41
32775008-1	2020	Vitamin D has a potential anticarcinogenic role, possibly through regulation of cell proliferation and differentiation, stimulation of apoptosis, immune modulation and regulation of estrogen receptor levels.	Vitamin D	0-9	estrogen receptor 1	Homo sapiens	182-199
32394724-2	2020	Considering the role of vitamin D (Vit D) in cardiovascular and immune functions, Vit D deficiency could affect ICU patients" outcomes.	Vitamin D	24-33	vitrin	Homo sapiens	35-38
32409924-1	2020	INTRODUCTION: Estrogen and prolactin affect vitamin D metabolism.	Vitamin D	44-53	prolactin	Rattus norvegicus	27-36
32251673-6	2020	Vitamin D promoted primary human ATII cells proliferation through the PI3K/AKT signaling pathway and activation of vitamin D receptor (VDR).	Vitamin D	0-9	AKT serine/threonine kinase 1	Homo sapiens	75-78
32350957-5	2020	Vitamin D fortification was associated with a significant improvement in fasting serum glucose (mean difference [MD]: -2.772; 95% confidence interval [CI]: -5.435 to -0.109) and fasting serum insulin (MD: -2.937; 95% CI: -4.695 to -1.178) in patients with Type 2 diabetes mellitus.	Vitamin D	0-9	insulin	Homo sapiens	192-199
32350957-6	2020	A diet with food enriched with Vitamin D was associated with a significant improvement in homeostatic model assessment of insulin resistance (MD: -1.608; 95% CI: -3.138 to -0.079) but was not associated with a significant reduction in hemoglobin A1C (MD: 0.034; 95% CI: -0.655 to 0.069).	Vitamin D	31-40	insulin	Homo sapiens	122-129
32394724-2	2020	Considering the role of vitamin D (Vit D) in cardiovascular and immune functions, Vit D deficiency could affect ICU patients" outcomes.	Vitamin D	24-33	vitrin	Homo sapiens	82-85
32325367-0	2020	Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin.	Vitamin D	82-91	C-reactive protein	Homo sapiens	112-130
32325367-0	2020	Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin.	Vitamin D	82-91	adiponectin, C1Q and collagen domain containing	Homo sapiens	143-154
32567548-10	2020	Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20-30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 +- 24.7pg/mL vs 44.2 +- 64.5pg/mL; p<0.01).	Vitamin D	24-33	parathyroid hormone	Homo sapiens	131-134
33534727-0	2020	The Effect of Vitamin D Supplementation on Insulin Sensitivity: A Systematic Review and Meta-analysis.	Vitamin D	14-23	insulin	Homo sapiens	43-50
33534727-1	2020	BACKGROUND: Vitamin D has been suggested to affect peripheral insulin sensitivity.	Vitamin D	12-21	insulin	Homo sapiens	62-69
33534727-2	2020	Evidence regarding the effect of vitamin D supplementation on insulin sensitivity is still conflicting.	Vitamin D	33-42	insulin	Homo sapiens	62-69
33534727-3	2020	PURPOSE: This meta-analysis aimed to assess the effect of vitamin D supplementation on insulin sensitivity in humans with or at risk for insulin resistance.	Vitamin D	58-67	insulin	Homo sapiens	87-94
33534727-3	2020	PURPOSE: This meta-analysis aimed to assess the effect of vitamin D supplementation on insulin sensitivity in humans with or at risk for insulin resistance.	Vitamin D	58-67	insulin	Homo sapiens	137-144
33534727-6	2020	We extracted data on the standardized mean difference between the vitamin D treatment and placebo groups in change from baseline insulin sensitivity.	Vitamin D	66-75	insulin	Homo sapiens	129-136
32567548-10	2020	Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20-30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 +- 24.7pg/mL vs 44.2 +- 64.5pg/mL; p<0.01).	Vitamin D	71-80	parathyroid hormone	Homo sapiens	131-134
31913874-0	2020	Low levels of serum vitamin D in clozapine-treated schizophrenia patients are associated with high levels of the proinflammatory cytokine IL-6.	Vitamin D	20-29	interleukin 6	Homo sapiens	138-142
32446146-10	2020	A higher odds of preterm birth at <34 weeks gestation was seen among women with maternal serum Alpha fetoprotein (AFP)>3.5 MoM (OR 2.35, 95 % CI 1.12-4.96, I2=NA) while higher odds of preterm birth at <32 weeks was seen among women with 25 Hydroxy Vitamin D level <75 nmol/l (OR 3.01, 95 % CI 1.26-7.19, I2=NA).	Vitamin D	248-257	alpha fetoprotein	Homo sapiens	95-112
32446146-10	2020	A higher odds of preterm birth at <34 weeks gestation was seen among women with maternal serum Alpha fetoprotein (AFP)>3.5 MoM (OR 2.35, 95 % CI 1.12-4.96, I2=NA) while higher odds of preterm birth at <32 weeks was seen among women with 25 Hydroxy Vitamin D level <75 nmol/l (OR 3.01, 95 % CI 1.26-7.19, I2=NA).	Vitamin D	248-257	alpha fetoprotein	Homo sapiens	114-117
32519507-8	2020	Serum antioxidative enzymes activity (GPx, CAT, and SOD) had significantly increased after vitamin D supplementation in the intervention group (P < 0.05).	Vitamin D	91-100	catalase	Homo sapiens	43-46
32519507-8	2020	Serum antioxidative enzymes activity (GPx, CAT, and SOD) had significantly increased after vitamin D supplementation in the intervention group (P < 0.05).	Vitamin D	91-100	superoxide dismutase 1	Homo sapiens	52-55
32519507-10	2020	DISCUSSION: Regular consumption of vitamin D can increase the GPx, CAT, SOD, and reduce the MDA plasma levels in HD patients.	Vitamin D	35-44	catalase	Homo sapiens	67-70
32519507-10	2020	DISCUSSION: Regular consumption of vitamin D can increase the GPx, CAT, SOD, and reduce the MDA plasma levels in HD patients.	Vitamin D	35-44	superoxide dismutase 1	Homo sapiens	72-75
32422661-6	2020	We found that vitamin D supplementation had a significant effect on insulin metabolism, total serum testosterone, hirsutism, C-reactive protein, and total antioxidant capacity in women with polycystic ovary syndrome.	Vitamin D	14-23	C-reactive protein	Homo sapiens	125-143
31913874-8	2020	There was a significant inverse correlation between serum vitamin D and IL-6 levels (Pearson"s r = -0.38, P &lt; 0.05).	Vitamin D	58-67	interleukin 6	Homo sapiens	72-76
31913874-10	2020	These results suggest that within clozapine-treated schizophrenia patients, high levels of vitamin D are associated with lower serum levels of the proinflammatory cytokine IL-6.	Vitamin D	91-100	interleukin 6	Homo sapiens	172-176
32314188-0	2020	Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling.	Vitamin D	0-9	claudin 2	Homo sapiens	20-29
32314188-0	2020	Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling.	Vitamin D	0-9	claudin 4	Homo sapiens	34-43
32314188-0	2020	Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling.	Vitamin D	0-9	SMAD family member 7	Homo sapiens	100-106
32314188-2	2020	The aim of this study was to determine whether vitamin D, which regulates the integrity of the epithelial barrier by expressing TJ proteins, reduces claudin-2 (Cl-2) levels by inhibiting Stat-6 phosphorylation and whether it increases claudin-4 (Cl-4) levels by blocking Smad-7 activity.	Vitamin D	47-56	claudin 2	Homo sapiens	149-158
32314188-2	2020	The aim of this study was to determine whether vitamin D, which regulates the integrity of the epithelial barrier by expressing TJ proteins, reduces claudin-2 (Cl-2) levels by inhibiting Stat-6 phosphorylation and whether it increases claudin-4 (Cl-4) levels by blocking Smad-7 activity.	Vitamin D	47-56	claudin 2	Homo sapiens	160-164
32314188-2	2020	The aim of this study was to determine whether vitamin D, which regulates the integrity of the epithelial barrier by expressing TJ proteins, reduces claudin-2 (Cl-2) levels by inhibiting Stat-6 phosphorylation and whether it increases claudin-4 (Cl-4) levels by blocking Smad-7 activity.	Vitamin D	47-56	claudin 4	Homo sapiens	235-244
32314188-2	2020	The aim of this study was to determine whether vitamin D, which regulates the integrity of the epithelial barrier by expressing TJ proteins, reduces claudin-2 (Cl-2) levels by inhibiting Stat-6 phosphorylation and whether it increases claudin-4 (Cl-4) levels by blocking Smad-7 activity.	Vitamin D	47-56	claudin 4	Homo sapiens	246-250
32314188-2	2020	The aim of this study was to determine whether vitamin D, which regulates the integrity of the epithelial barrier by expressing TJ proteins, reduces claudin-2 (Cl-2) levels by inhibiting Stat-6 phosphorylation and whether it increases claudin-4 (Cl-4) levels by blocking Smad-7 activity.	Vitamin D	47-56	SMAD family member 7	Homo sapiens	271-277
32314188-10	2020	CONCLUSIONS: Our results indicate that the effects of vitamin D on Cl-2 and Cl-4 are mediated by p-Stat-6 and Smad-7 signal, respectively.	Vitamin D	54-63	claudin 2	Homo sapiens	67-71
32314188-10	2020	CONCLUSIONS: Our results indicate that the effects of vitamin D on Cl-2 and Cl-4 are mediated by p-Stat-6 and Smad-7 signal, respectively.	Vitamin D	54-63	claudin 4	Homo sapiens	76-80
32314188-10	2020	CONCLUSIONS: Our results indicate that the effects of vitamin D on Cl-2 and Cl-4 are mediated by p-Stat-6 and Smad-7 signal, respectively.	Vitamin D	54-63	SMAD family member 7	Homo sapiens	110-116
32323557-11	2020	The comparison of serum IGF-1 showed significant difference after 3 days (P = .006) and remained higher in vitamin D group after CPB (P < .001).	Vitamin D	107-116	insulin like growth factor 1	Homo sapiens	24-29
33680012-0	2020	The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study.	Vitamin D	23-32	adiponectin, C1Q and collagen domain containing	Homo sapiens	70-81
33680012-0	2020	The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study.	Vitamin D	23-32	insulin	Homo sapiens	94-101
33680012-2	2020	Vitamin D contributes to insulin synthesis and secretion.	Vitamin D	0-9	insulin	Homo sapiens	25-32
33680012-3	2020	Deficiency of vitamin D leads to insulin resistance which is the major cause of type 2 diabetes mellitus.	Vitamin D	14-23	insulin	Homo sapiens	33-40
33680012-4	2020	We aim to evaluate the effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin, and leptin to adiponectin ratio (LAR) of type 2 diabetes mellitus patients.	Vitamin D	42-51	adiponectin, C1Q and collagen domain containing	Homo sapiens	89-100
33680012-4	2020	We aim to evaluate the effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin, and leptin to adiponectin ratio (LAR) of type 2 diabetes mellitus patients.	Vitamin D	42-51	adiponectin, C1Q and collagen domain containing	Homo sapiens	124-135
33680012-8	2020	The results of study indicate a significant decline in circulating leptin and adiponectin after vitamin D treatment, but it doesn"t cause a noteworthy change in LAR.	Vitamin D	96-105	adiponectin, C1Q and collagen domain containing	Homo sapiens	78-89
32392443-2	2020	Vitamin D and fiber intake are nutritional factors that could affect the development of type 2 diabetes (T2D), potentially by reducing insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	135-142
32407867-7	2020	In patients with vitamin D deficiency (defined as serum 25-hydroxyvitamin D levels 15 ng/mL or lower), gland weight, PTH, AP, and adjusted calcium were each significantly higher than in patients with 25-hydroxyvitamin D levels of 16 ng/mL or higher, but serum 1,25-dihydroxyvitamin D levels were similar in both groups.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	117-120
32545801-2	2020	The active form of vitamin D (1,25(OH)2D3), which acts via its nuclear hormone receptor, vitamin D receptor (VDR), has been implicated in the treatment of Abeta pathology, and is thus considered as a neuroprotective agent.	Vitamin D	19-28	amyloid beta precursor protein	Homo sapiens	155-160
32533118-6	2020	Genetic approaches, studying both monogenic and polygenic factors in nephrolithiasis, have revealed that the following have important roles in the aetiology of kidney stones: transporters and channels; ions, protons and amino acids; the calcium-sensing receptor (a G protein-coupled receptor) signalling pathway; and the metabolic pathways for vitamin D, oxalate, cysteine, purines and uric acid.	Vitamin D	344-353	calcium sensing receptor	Homo sapiens	237-261
32597305-3	2021	Odd ratio (OR) with 95% confidence intervals (CIs) was calculated comparing vitamin D deficiency children to normal vitamin D children on the bases of sepsis and mortality in acute and critical care units using the dichotomous method with a random effect model.	Vitamin D	76-85	odd-skipped related transcription factor 1	Homo sapiens	0-3
32597305-3	2021	Odd ratio (OR) with 95% confidence intervals (CIs) was calculated comparing vitamin D deficiency children to normal vitamin D children on the bases of sepsis and mortality in acute and critical care units using the dichotomous method with a random effect model.	Vitamin D	116-125	odd-skipped related transcription factor 1	Homo sapiens	0-3
32353742-2	2020	Like tocilizumab, Vitamin D appears to modulate the activity of an interleukin (IL-6), which may explain the seasonal variation in prevalence of influenza.	Vitamin D	18-27	interleukin 6	Homo sapiens	80-84
32452516-3	2020	The present study aimed to further investigate the effects of vitamin D and vitamin D receptor (Vdr) on Ucps (Ucp1-3) expression in brown adipocyte and the mechanism involved in it.	Vitamin D	62-71	uncoupling protein 1	Rattus norvegicus	110-116
32585876-8	2020	Moreover, induction of aortas medial calcification and concomitant IL6 expression, with an overdose of vitamin D, was reduced in male C57BL/6J Mir34a-/- mice.	Vitamin D	103-112	interleukin 6	Mus musculus	67-70
32585876-8	2020	Moreover, induction of aortas medial calcification and concomitant IL6 expression, with an overdose of vitamin D, was reduced in male C57BL/6J Mir34a-/- mice.	Vitamin D	103-112	microRNA 34a	Mus musculus	143-149
32517740-0	2020	Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer.	Vitamin D	51-60	secreted frizzled related protein 2	Homo sapiens	80-115
32517740-6	2020	Therefore, the aim of this study was to find an association between circulating 25-OH vitamin D (30th percentile of vitamin D) and the SFRP2 methylation.	Vitamin D	86-95	secreted frizzled related protein 2	Homo sapiens	135-140
32517740-6	2020	Therefore, the aim of this study was to find an association between circulating 25-OH vitamin D (30th percentile of vitamin D) and the SFRP2 methylation.	Vitamin D	116-125	secreted frizzled related protein 2	Homo sapiens	135-140
32517740-11	2020	Finally, we tested the effect of vitamin D on the SFRP2 methylation in human colorectal carcinoma cell lines 116 (HCT116) and studied the association of neoadjuvant therapy under the 30th percentile vitamin D with SFRP2 promoter methylation.	Vitamin D	199-208	secreted frizzled related protein 2	Homo sapiens	214-219
32517740-12	2020	RESULTS: SFRP2 methylation in tumor area was decreased in patients who had higher levels of vitamin D.	Vitamin D	92-101	secreted frizzled related protein 2	Homo sapiens	9-14
32517740-16	2020	CONCLUSION: Our results showed that higher circulating vitamin D is associated with low SFRP2 promoter methylation.	Vitamin D	55-64	secreted frizzled related protein 2	Homo sapiens	88-93
32582667-6	2020	The bioactive form of vitamin D (aVD; 1, 25-Dihydroxyvitamin D3), which inhibits pro-inflammatory transcription factor NF-kappaB via the intracellular nuclear hormone receptor vitamin D receptor (VDR), was stably loaded into poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) filomicelles.	Vitamin D	22-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
32582730-1	2020	Aims/Introduction: Chronic kidney disease (CKD)-mineral and bone disorders (CKD-MBD) are an adverse outcome derived from decreases in kidney function, where abnormality of serum concentrations of calcium (Ca), phosphorus, parathyroid hormone (PTH), and vitamin D can be seen simultaneously.	Vitamin D	253-262	parathyroid hormone	Homo sapiens	222-241
32582730-7	2020	Conclusions: These results indicate that a reduction in eGFR is a significant risk factor for an increase in serum PTH concentration when it is <60 mL/min/1.73 m2 and vitamin D is deficient, in the general Japanese population.	Vitamin D	167-176	parathyroid hormone	Homo sapiens	115-118
32045698-0	2020	Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action.	Vitamin D	94-103	insulin	Homo sapiens	11-18
31815524-0	2020	Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK/mTOR signaling pathway.	Vitamin D	7-16	mechanistic target of rapamycin kinase	Homo sapiens	97-101
32450764-6	2020	A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = -0.280, p < 0.05; r = -0.407, p = 0.038; r = -0.445, p = 0.005), respectively.	Vitamin D	52-61	parathyroid hormone	Homo sapiens	86-105
31815524-7	2020	VD treatment elevated p-AMPK/AMPK and decreased p-mTOR/mTOR, and it increased LC3II/LC3I, increased the protein level of Beclin-1, but decreased p62 according to Western blot analysis.	Vitamin D	0-2	mechanistic target of rapamycin kinase	Homo sapiens	50-54
31815524-7	2020	VD treatment elevated p-AMPK/AMPK and decreased p-mTOR/mTOR, and it increased LC3II/LC3I, increased the protein level of Beclin-1, but decreased p62 according to Western blot analysis.	Vitamin D	0-2	mechanistic target of rapamycin kinase	Homo sapiens	55-59
31815524-8	2020	Besides, VD reduced the contents of tumor necrosis factor-alpha and interleukin-6 both in cartilage tissues and in chondrocytes.	Vitamin D	9-11	tumor necrosis factor	Homo sapiens	36-63
31815524-8	2020	Besides, VD reduced the contents of tumor necrosis factor-alpha and interleukin-6 both in cartilage tissues and in chondrocytes.	Vitamin D	9-11	interleukin 6	Homo sapiens	68-81
31815524-12	2020	This study provided evidence that active VD might activate chondrocyte autophagy to reduce OA inflammation via activating the AMPK/mTOR signaling pathway.	Vitamin D	41-43	mechanistic target of rapamycin kinase	Homo sapiens	131-135
32102946-4	2020	We selected 21 SNPs in vitamin D-related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1, DHCR7, NADSYN1) to test genotype and genotype-treatment interactions in relation to prostate cancer.	Vitamin D	23-32	chromosome 10 open reading frame 88	Homo sapiens	57-65
32102946-4	2020	We selected 21 SNPs in vitamin D-related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1, DHCR7, NADSYN1) to test genotype and genotype-treatment interactions in relation to prostate cancer.	Vitamin D	23-32	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	84-91
32339669-0	2020	Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1alpha pathway in chronic spontaneous urticaria.	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	37-71
30987555-2	2020	The aim of this study was to demonstrate that vitamin D deficiency may be due to variants of vitamin D binding protein (DBP) among otherwise healthy Iranian adults.	Vitamin D	46-55	D-box binding PAR bZIP transcription factor	Homo sapiens	120-123
32238406-12	2020	CONCLUSIONS: Our findings support an intriguing line of research to better understand the mechanisms underlying the role of vitamin D in breast tumor progression, particularly for the ER-positive subtype.	Vitamin D	124-133	estrogen receptor 1	Homo sapiens	184-186
32339669-0	2020	Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1alpha pathway in chronic spontaneous urticaria.	Vitamin D	0-9	AKT serine/threonine kinase 1	Homo sapiens	104-107
32339669-0	2020	Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1alpha pathway in chronic spontaneous urticaria.	Vitamin D	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
32655726-0	2020	Use of Vitamin D With Anti-Tumor Necrosis Factor Therapy for Crohn"s Disease.	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	27-48
32450764-6	2020	A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = -0.280, p < 0.05; r = -0.407, p = 0.038; r = -0.445, p = 0.005), respectively.	Vitamin D	52-61	insulin	Homo sapiens	143-150
32458373-6	2020	At the same time, vitamin D deficiency (< 20 ng/ml) increases parathyroid hormone levels and thus promotes bone loss and the risk of fracture.	Vitamin D	18-27	parathyroid hormone	Homo sapiens	62-81
32517587-11	2020	The SNP frequency in CYP2R1 (rs10741657) and DBP (rs2282679) in the vitamin D deficient group was significantly higher than in the control group (p-values < 0.001 and 0.01 respectively).	Vitamin D	68-77	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
32485124-7	2020	Ang-II, IL-6, and TNF-alpha concentrations were all reduced after vitamin D supplementation.	Vitamin D	66-75	angiotensinogen	Homo sapiens	0-6
31868234-2	2020	Binding of the active vitamin D metabolite, 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) to the vitamin D receptor (VDR) induces conformational changes in its C-terminal domain enabling competency for interaction with physiologically relevant coactivators, including SRC-1.	Vitamin D	22-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	264-269
32485124-7	2020	Ang-II, IL-6, and TNF-alpha concentrations were all reduced after vitamin D supplementation.	Vitamin D	66-75	interleukin 6	Homo sapiens	8-12
32485124-7	2020	Ang-II, IL-6, and TNF-alpha concentrations were all reduced after vitamin D supplementation.	Vitamin D	66-75	tumor necrosis factor	Homo sapiens	18-27
32213352-2	2020	One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	87-121
31623529-1	2020	The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women.	Vitamin D	103-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
32213352-2	2020	One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	123-128
32213352-2	2020	One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	146-188
32213352-2	2020	One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	190-195
32213352-8	2020	Increased VDR and decreased CRAMP expression are consistent with previously reported associations between vitamin D deficiency, immune dysregulation, and suicidal behavior, and should lead to future studies uncovering novel interactive targets for suicide prevention.	Vitamin D	106-115	cathelicidin antimicrobial peptide	Homo sapiens	28-33
32449055-0	2020	Decreased Serum Adiponectin Reflects Low Vitamin D, High Interleukin 6, and Poor Physical Performance in Knee Osteoarthritis.	Vitamin D	41-50	adiponectin, C1Q and collagen domain containing	Homo sapiens	16-27
32142934-1	2020	Extra-renal expression of Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1) has been well recognized and reflects the importance of intracrine/paracrine vitamin D signaling in different tissues under physiological and pathological conditions.	Vitamin D	160-169	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	26-72
32142934-1	2020	Extra-renal expression of Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1) has been well recognized and reflects the importance of intracrine/paracrine vitamin D signaling in different tissues under physiological and pathological conditions.	Vitamin D	160-169	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	74-81
32515572-10	2020	In obesity the real vitamin D deficiency could be estimate by serum 1,25(OH)2D concentrations whose lower levels contribute to the higher PTH production and consequently to bone loss and to a greater fracture risk.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	138-141
32671009-0	2020	Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	100-104
32671009-7	2020	Vitamin D stimulates transcription of cathelicidin which is cleaved to generate LL37.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	80-84
32515572-2	2020	Vitamin D is the key regulator of bone metabolism and its deficiency contributes to higher level of parathyroid hormone (PTH), leading to the activation of bone turnover.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	100-119
32515572-2	2020	Vitamin D is the key regulator of bone metabolism and its deficiency contributes to higher level of parathyroid hormone (PTH), leading to the activation of bone turnover.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	121-124
32393583-0	2020	Vitamin D supplementation rescues aberrant NF-kappaB pathway activation and partially ameliorates Rett syndrome phenotypes in Mecp2 mutant mice.	Vitamin D	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
31282535-10	2020	CONCLUSION: The association of low vitamin D with slow gait speed statistically interacts with high IL-6.	Vitamin D	35-44	interleukin 6	Homo sapiens	100-104
32441564-3	2022	In this study, we report PTH levels according to the vitamin D status and BALP levels in a large cohort of 1200 children.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	25-28
32393583-3	2020	Here, we investigate whether the known NF-kappaB pathway inhibitor vitamin D ameliorates neuronal phenotypes in Mecp2-mutant mice.	Vitamin D	67-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-48
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	17-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	186-195	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
32393583-9	2020	Here, we identify that the known NF-kappaB inhibitor vitamin D reduces the aberrant NF-kappaB signaling in Mecp2 knockdown neurons, and partially ameliorates neuronal size and complexity phenotypes in both male and female Mecp2-mutant mice.	Vitamin D	53-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
32393583-9	2020	Here, we identify that the known NF-kappaB inhibitor vitamin D reduces the aberrant NF-kappaB signaling in Mecp2 knockdown neurons, and partially ameliorates neuronal size and complexity phenotypes in both male and female Mecp2-mutant mice.	Vitamin D	53-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93
32435279-9	2020	Conclusion: Vitamin D and omega-3 co-supplementation improved fasting serum glucose, insulin, high-density lipoprotein-cholesterol level, homeostasis model assessment-beta cell function, weight and waist circumference in women of reproductive age with prediabetes and hypovitaminosis D. This co-supplementation can therefore be recommended for glycemic control in these women.Trial registration Iranian Registry of Clinical Trials Code: IRCT20100130003226N17.	Vitamin D	12-21	insulin	Homo sapiens	85-92
32508805-13	2020	Important for cellular therapies requiring isolation of Tregs, the absolute number of beta7+CD4+CD25+FOXP3+Tregs was positively associated with 25(OH)vitamin D3 (R 2 = 0.0208, r = 0.184, p = 0.021) whereas the absolute numbers of CLA+CD4+CD25+FOXP3+Tregs in the periphery were not influenced by vitamin D status.	Vitamin D	150-159	CD4 molecule	Homo sapiens	92-95
32407388-2	2020	We wanted to investigate possible associations of polymorphisms in genes involved in vitamin D metabolism with indices of insulin resistance and insulin secretion, and also with development of diabetes after gestational diabetes mellitus (GDM).	Vitamin D	85-94	insulin	Homo sapiens	122-129
32407388-2	2020	We wanted to investigate possible associations of polymorphisms in genes involved in vitamin D metabolism with indices of insulin resistance and insulin secretion, and also with development of diabetes after gestational diabetes mellitus (GDM).	Vitamin D	85-94	insulin	Homo sapiens	145-152
32494176-0	2020	Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals.	Vitamin D	4-13	insulin	Homo sapiens	109-116
32367244-0	2020	Seasonal periodicity of serum parathyroid hormone and its relation with vitamin D in Romania.	Vitamin D	72-81	parathyroid hormone	Homo sapiens	30-49
32494176-2	2020	Vitamin D deficiency was shown to be associated with dyslipidemia; however, the type of dyslipidemia associated with vitamin D deficiency in insulin-resistant individuals is not determined.	Vitamin D	117-126	insulin	Homo sapiens	141-148
32494176-12	2020	Conclusion: The results of our study showed that in insulin-resistant individuals, vitamin D deficiency status is associated with HDL-C dyslipidemia and higher serum inflammatory and endothelial damage markers.	Vitamin D	83-92	insulin	Homo sapiens	52-59
32371900-7	2020	In addition, the CTR was higher in patients with vitamin D deficiency than in those without vitamin D deficiency.	Vitamin D	49-58	calcitonin receptor	Homo sapiens	17-20
32371900-7	2020	In addition, the CTR was higher in patients with vitamin D deficiency than in those without vitamin D deficiency.	Vitamin D	92-101	calcitonin receptor	Homo sapiens	17-20
32371900-8	2020	After multivariate logistic regression, we found that CTR was the solitary factor that was independently significantly associated with vitamin D deficiency [odds ratio: 1.07, 95% confidence internal (CI): 1.01-1.13, p = 0.02].	Vitamin D	135-144	calcitonin receptor	Homo sapiens	54-57
32371900-9	2020	Additionally, vitamin D deficiency was associated with all-cause mortality in patients with higher CTR after adjustment in hierarchical regression models.	Vitamin D	14-23	calcitonin receptor	Homo sapiens	99-102
32371900-10	2020	In conclusion, we reported that vitamin D deficiency was independently significantly associated with a higher CTR.	Vitamin D	32-41	calcitonin receptor	Homo sapiens	110-113
32371900-11	2020	We additionally revealed that vitamin D deficiency was an independent predicator for all-cause mortality in higher CTR hemodialysis patients.	Vitamin D	30-39	calcitonin receptor	Homo sapiens	115-118
31961707-0	2020	TGF-beta1 promotes vitamin D-induced prostaglandin E2 synthesis by upregulating vitamin D receptor expression in human granulosa-lutein cells.	Vitamin D	19-28	transforming growth factor beta 1	Homo sapiens	0-9
31961707-1	2020	There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health.	Vitamin D	55-64	vitrin	Homo sapiens	66-69
31961707-7	2020	Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells.	Vitamin D	87-92	transforming growth factor beta 1	Homo sapiens	27-36
31961707-7	2020	Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells.	Vitamin D	87-92	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
31961707-7	2020	Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells.	Vitamin D	87-92	mitogen-activated protein kinase 3	Homo sapiens	177-183
31961707-7	2020	Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells.	Vitamin D	87-92	lipase F, gastric type	Homo sapiens	206-209
32366390-2	2020	Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia.	Vitamin D	37-46	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-18
32366390-2	2020	Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia.	Vitamin D	37-46	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	20-27
32483402-9	2020	While perifosine+vitamin D combinations increased P53 mRNA expression in HEC-1A cells we did not find any significant change in BCL2, BAX mRNA expression levels.	Vitamin D	17-26	tumor protein p53	Homo sapiens	50-53
32391251-9	2020	Having PTH >= 6 pmol/L was also associated with a higher likelihood of having vitamin D deficiency.	Vitamin D	78-87	parathyroid hormone	Homo sapiens	7-10
32367244-2	2020	PTH was dependent on serum vitamin D, particularly below 12.82 ng/mL.	Vitamin D	27-36	parathyroid hormone	Homo sapiens	0-3
31957666-2	2020	This study aimed to assess the effect of vitamin D on serum levels of proangiogenic factors, visfatin and vascular endothelial growth factor (VEGF), in patients with UC.	Vitamin D	41-50	vascular endothelial growth factor A	Homo sapiens	106-140
32444034-0	2020	The effect of vitamin D supplementation on insulin-like growth factor-1: A systematic review and meta-analysis of randomized controlled trials.	Vitamin D	14-23	insulin like growth factor 1	Homo sapiens	43-71
32444034-1	2020	PURPOSE: There is equivocality regarding the interaction between vitamin D and insulin-like growth factor-1 (IGF-1).	Vitamin D	65-74	insulin like growth factor 1	Homo sapiens	109-114
32444034-2	2020	Thus, the aim of this study was to elucidate the effect of vitamin D supplementation on serum levels of IGF-1 by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).	Vitamin D	59-68	insulin like growth factor 1	Homo sapiens	104-109
32444034-3	2020	METHODS: PubMed, Scopus, and ISI Web of Science databases were searched up to May 2019 for RCTs that evaluated the effect of vitamin D supplementation on IGF-1 levels.	Vitamin D	125-134	insulin like growth factor 1	Homo sapiens	154-159
31957666-2	2020	This study aimed to assess the effect of vitamin D on serum levels of proangiogenic factors, visfatin and vascular endothelial growth factor (VEGF), in patients with UC.	Vitamin D	41-50	vascular endothelial growth factor A	Homo sapiens	142-146
32412426-8	2020	Serum parathyroid hormone (PTH) and change in PTH after vitamin D supplementation were related to serum 25(OH)D levels in steps of 25 nmol/L (<24, 25-49, 50-74, 75-99, and >99 nmol/L).	Vitamin D	56-65	parathyroid hormone	Homo sapiens	46-49
32113022-6	2020	Pooling 9 effect sizes from 8 RCTs on C-reactive protein (CRP) levels revealed a significant reducing effect of vitamin d-calcium co-supplementation on serum CRP concentrations compared to placebo intake (WMD: -0.82, 95% CI: -1.56, -0.07 mg/L, P = 0.03).	Vitamin D	112-121	C-reactive protein	Homo sapiens	38-56
32113022-6	2020	Pooling 9 effect sizes from 8 RCTs on C-reactive protein (CRP) levels revealed a significant reducing effect of vitamin d-calcium co-supplementation on serum CRP concentrations compared to placebo intake (WMD: -0.82, 95% CI: -1.56, -0.07 mg/L, P = 0.03).	Vitamin D	112-121	C-reactive protein	Homo sapiens	58-61
32113022-6	2020	Pooling 9 effect sizes from 8 RCTs on C-reactive protein (CRP) levels revealed a significant reducing effect of vitamin d-calcium co-supplementation on serum CRP concentrations compared to placebo intake (WMD: -0.82, 95% CI: -1.56, -0.07 mg/L, P = 0.03).	Vitamin D	112-121	C-reactive protein	Homo sapiens	158-161
32113022-8	2020	Also, we found that the associations of vitamin d-calcium dosages and duration of intervention with the reduction in CRP concentrations were in a non-linear fashion.	Vitamin D	40-49	C-reactive protein	Homo sapiens	117-120
32113022-10	2020	We found a beneficial effect of vitamin d-calcium co-supplementation on serum CRP concentrations.	Vitamin D	32-41	C-reactive protein	Homo sapiens	78-81
32412426-10	2020	In pooled RCTs, there was a significant reduction in serum PTH by vitamin D supplementation regardless of baseline serum 25(OH)D level.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	59-62
32874076-13	2020	Age > 50 years, being housewife, use of antiepileptic medications (AEDs), and higher serum parathyroid hormone are associated with severe vitamin D deficiency.	Vitamin D	138-147	parathyroid hormone	Homo sapiens	91-110
32127688-0	2020	CYP27B1 as an instrument gene to investigate the causal relationship between vitamin D deficiency and obesity: a family-based study.	Vitamin D	77-86	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
32127688-4	2020	We aimed to investigate the family-based association of SNPs in CYP27B1 with both vitamin D deficiency and obesity.	Vitamin D	82-91	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-71
32127688-6	2020	Family-based associations of rs10877012 and rs4646536 in CYP27B1 with vitamin D deficiency and obesity were investigated.	Vitamin D	70-79	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	57-64
32357490-2	2020	Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation.	Vitamin D	38-47	insulin	Homo sapiens	81-88
32580859-5	2020	A lot of researches have to be directed to examine the association among the PCOS and vitamin D, which may display monitoring role in several symptoms related to PCOS, such as ovulatory dysfunction, endocrine disruption, and insulin resistance.	Vitamin D	86-95	insulin	Homo sapiens	225-232
32001361-1	2020	Renal and extrarenal production of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is catalyzed by CYP27B1, an enzyme also called 1-alpha-hydroxylase.	Vitamin D	54-63	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	119-126
32007562-10	2020	Group differences in relationships between vitamin D metabolites and with PTH were investigated with multiple regression analyses.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	74-77
32367810-10	2020	S-PTH was negatively correlated to vitamin D concentrations at ages 7, 15 and 17 but there was not a significant correlation at age 9.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	2-5
32148208-0	2020	Association of seasonality and serum albumin concentration with vitamin D deficiency in subjects with chronic hepatitis C infection living in a sunny country.	Vitamin D	64-73	albumin	Homo sapiens	37-44
32148208-10	2020	In multivariate analysis, vitamin D deficiency was found to be independently associated with male gender, serum albumin concentration and with samples drawn in winter and spring.	Vitamin D	26-35	albumin	Homo sapiens	112-119
31669079-9	2020	Evidence was fair that vitamin D supplementation significantly decreases maternal homeostatic model assessment-insulin resistance (five studies, n=7; -1.1, -1.5, -0.7) and increases infant birth weight (nine studies, n=11, 114.2, 63.4, 165.1 g), both had insignificant heterogeneity.	Vitamin D	23-32	insulin	Homo sapiens	111-118
31669079-11	2020	CONCLUSIONS: Results show vitamin D supplementation during pregnancy improves maternal and infant 25(OH)D concentrations and may play a role in maternal insulin resistance and fetal growth.	Vitamin D	26-35	insulin	Homo sapiens	153-160
31945466-0	2020	25(OH)D3 stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated.	Vitamin D	38-47	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	89-96
32369848-9	2020	CONCLUSION:  Low circulating vitamin D concentrations are associated with increased platelet fibrinogen binding to integrin alphaIIbbeta3 in unstimulated samples and after stimulation with CRP-XL.	Vitamin D	29-38	fibrinogen beta chain	Homo sapiens	93-103
32112703-0	2020	Vitamin D status and its relation to insulin resistance in a Mexican pediatric population.	Vitamin D	0-9	insulin	Homo sapiens	37-44
32112703-4	2020	Studies on adults have reported an inverse association between vitamin D levels and insulin resistance (IR), but the results in children are inconsistent.	Vitamin D	63-72	insulin	Homo sapiens	84-91
32395119-0	2020	Reformulating Small Molecules for Cardiovascular Disease Immune Intervention: Low-Dose Combined Vitamin D/Dexamethasone Promotes IL-10 Production and Atheroprotection in Dyslipidemic Mice.	Vitamin D	96-105	interleukin 10	Mus musculus	129-134
32344842-7	2020	RESULTS: Between-groups statistical analysis showed that a dose (50,000 IU/month) vitamin D significantly increased the serum levels of 25-hydroxyvitamin D (25 (OH) D) (p < 0.001) and decreased serum levels of PTH (p = 0.003).	Vitamin D	82-91	parathyroid hormone	Homo sapiens	210-213
32395119-6	2020	Concomitantly, the frequency of IFNgamma-producing CD4+ and CD8+ T cells in the spleen, and the IFNgamma response of splenocytes to polyclonal stimulation ex vivo were lower after VitD/Dexa treatment, indicating a reduced proatherogenic Th1 response.	Vitamin D	180-184	interferon gamma	Mus musculus	32-40
32395119-6	2020	Concomitantly, the frequency of IFNgamma-producing CD4+ and CD8+ T cells in the spleen, and the IFNgamma response of splenocytes to polyclonal stimulation ex vivo were lower after VitD/Dexa treatment, indicating a reduced proatherogenic Th1 response.	Vitamin D	180-184	interferon gamma	Mus musculus	96-104
32395119-10	2020	Altogether, these results indicate that a non-toxic, non-immunosuppressive, low-dose of VitD/Dexa, administered subcutaneously and repetitively, exerts atheroprotective effects in dyslipidemic mice, apparently due to the induction of an IL-10-producing network of lymphoid and myeloid immune cells.	Vitamin D	88-92	interleukin 10	Mus musculus	237-242
32268827-10	2021	Measurement of parathyroid hormone decline added diagnostic value for one patient with preoperative parathyroid-hormone-elevation associated with vitamin D deficiency.	Vitamin D	146-155	parathyroid hormone	Homo sapiens	15-34
32237947-0	2022	Intralesional Injection of Vitamin D in Verruca Vulgaris Increases Cathelicidin (LL37) Expression; Therapeutic and Immunohistochemical Study.	Vitamin D	27-36	cathelicidin antimicrobial peptide	Homo sapiens	81-85
32237947-1	2022	Introduction: Despite the promising results of intralesional vitamin D in verruca treatment; its precise mechanism of action is not fully understood.Aim of the work: To investigate immunohistochemical expression of cathelicidin (LL 37) before and after injection of vitamin D in verruca vulgaris and to clarify its possible role in pathogenesis of verruca.Patients and methods: This study included 20 patients with multiple verrucae vulgaris.	Vitamin D	61-70	cathelicidin antimicrobial peptide	Homo sapiens	229-234
32237947-5	2022	Significant increase in LL37 intensity of expression was observed after intralesional injection of vitamin D3 (p = 0.003) and in verrucae showing complete clinical response (p = 0.022).Conclusions: Intralesional injection of vitamin D is effective and safe treatment for verruca vulgaris and causes increase in LL37 expression.	Vitamin D	99-108	cathelicidin antimicrobial peptide	Homo sapiens	24-28
32272973-10	2020	The vitamin D supplementation decreased post-exercise (TN max) and 1 h post-exercise troponin (p = 0.004, p = 0.03, respectively), 1 h post-exercise myoglobin concentration (p = 0.01) and TNF-alpha levels(p < 0.03).	Vitamin D	4-13	tumor necrosis factor	Homo sapiens	188-197
31889334-6	2020	Recent findings also suggest that part of the anti-cancer effects of vitamin D within squamous cell carcinoma - a type of skin cancer most directly linked to sun exposure - involves the DDIT4-mTOR catabolic signaling pathway to enhance cell autophagy.	Vitamin D	69-78	mechanistic target of rapamycin kinase	Homo sapiens	192-196
32233807-6	2020	Administration of vitamin D to diabetic rats resulted in a decrease of serum glucose, serum ADMA, a decrease of aortic MDA levels, ET-1 and iNOS activity, an increase of aortic SOD activity, NO levels, and cNOS activity.	Vitamin D	18-27	endothelin 1	Rattus norvegicus	131-135
32233807-6	2020	Administration of vitamin D to diabetic rats resulted in a decrease of serum glucose, serum ADMA, a decrease of aortic MDA levels, ET-1 and iNOS activity, an increase of aortic SOD activity, NO levels, and cNOS activity.	Vitamin D	18-27	nitric oxide synthase 2	Rattus norvegicus	140-144
32260235-3	2020	It was demonstrated that rs10877012 polymorphism in the CYP27B1 gene influenced the circulating vitamin D level.	Vitamin D	96-105	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	56-63
32052217-8	2020	CONCLUSION: Our findings suggest that excess adiposity confers resistance to vitamin D efficacy in suppressing PTH levels, even when given at high doses.	Vitamin D	77-86	parathyroid hormone	Homo sapiens	111-114
32172522-9	2020	A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-alpha p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-gamma (p = 0.65) compared to the control group.	Vitamin D	82-91	interleukin 6	Homo sapiens	107-111
32172522-9	2020	A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-alpha p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-gamma (p = 0.65) compared to the control group.	Vitamin D	82-91	tumor necrosis factor	Homo sapiens	122-131
32172522-9	2020	A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-alpha p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-gamma (p = 0.65) compared to the control group.	Vitamin D	82-91	interleukin 2	Homo sapiens	142-146
31889334-7	2020	As mTOR activity and cellular metabolism are modulated as part of the DNA damage response, insights into the means by which mTOR can be controlled by vitamin D to suppress cancer is of molecular and clinical importance.	Vitamin D	150-159	mechanistic target of rapamycin kinase	Homo sapiens	3-7
32172522-9	2020	A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-alpha p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-gamma (p = 0.65) compared to the control group.	Vitamin D	82-91	interferon gamma	Homo sapiens	183-192
31889334-7	2020	As mTOR activity and cellular metabolism are modulated as part of the DNA damage response, insights into the means by which mTOR can be controlled by vitamin D to suppress cancer is of molecular and clinical importance.	Vitamin D	150-159	mechanistic target of rapamycin kinase	Homo sapiens	124-128
32014085-2	2020	We tested the hypothesis that vitamin D deficiency increases the risk for colitis-associated colon cancer (CAC) by using an established CAC mouse model, 129-Smad3tm1Par/J(Smad3-/-) mice, which have defective transforming growth factor beta-signaling and develop colitis and CAC after the administration of dextran sodium sulfate (DSS).	Vitamin D	30-39	general transcription factor III A	Mus musculus	228-239
31783153-1	2020	In humans and other primates, 1,25(OH)2vitamin D3 regulates the expression of the cathelicidin antimicrobial peptide (CAMP) gene via toll-like receptor (TLR) signaling that activates the vitamin D pathway.	Vitamin D	39-48	cathelicidin antimicrobial peptide	Homo sapiens	82-116
32047095-6	2020	We also found suggestive cross-associated loci for neonatal and maternal vitamin D near immune genes, such as CXCL6-IL8 and ACKR1 We found no interactions with ASD.	Vitamin D	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
31809868-13	2020	In addition, leptin downregulated CYP24A1 and upregulated CYP27B1, CYP27A1 and VDR, which play vital roles in vitamin D metabolism.	Vitamin D	110-119	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	58-65
32067036-1	2020	Vitamin D, an essential steroid hormone in the human body, plays important roles in not only regulation of calcium and phosphorus metabolism, but also various physiological processes, such as cell differentiation and apoptosis, inflammation, and insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	246-253
32256745-7	2020	In conclusion, the data from the available randomized controlled trials (RCTs) suggested vitamin D supplementation reduced insulin resistance and hyperandrogenism, as well improving the lipid metabolism of patients with PCOS to an extent.	Vitamin D	89-98	insulin	Homo sapiens	123-130
31783153-1	2020	In humans and other primates, 1,25(OH)2vitamin D3 regulates the expression of the cathelicidin antimicrobial peptide (CAMP) gene via toll-like receptor (TLR) signaling that activates the vitamin D pathway.	Vitamin D	39-48	cathelicidin antimicrobial peptide	Homo sapiens	118-122
32610842-4	2020	Aims and Objectives: This cross-sectional study is designed "To assess Vitamin D status in CKD patients and to correlate Vitamin D status with eGFR.	Vitamin D	121-130	epidermal growth factor receptor	Homo sapiens	143-147
31982424-0	2020	Active Form of Vitamin D Analogue Mitigates Neurodegenerative Changes in Alzheimer"s Disease in Rats by Targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways.	Vitamin D	15-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
32610842-17	2020	The positive correlation was found between eGFR and vitamin D level and that was statistically significant.	Vitamin D	52-61	epidermal growth factor receptor	Homo sapiens	43-47
32610842-20	2020	eGFR was strongly associated with serum vitamin-D level.	Vitamin D	40-49	epidermal growth factor receptor	Homo sapiens	0-4
32235811-6	2020	Vitamin D presence led to higher protein expression of CD31, and lower protein expressions of alpha-SMA and FN compared to the control in the TGF-beta1-induced fibrosis model.	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	142-151
32197412-2	2020	Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation.	Vitamin D	101-110	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	65-72
32183160-4	2020	We hypothesized that vitamin D metabolites could be used with EGFR TKIs to prevent therapeutic failure.	Vitamin D	21-30	epidermal growth factor receptor	Homo sapiens	62-66
32183160-11	2020	We conclude that vitamin D sufficiency portends increased PFS among EGFR-mutant LUAD patients that receive EGFR TKIs, and that vitamin D signaling maintains drug efficacy in this specific patient subset by opposing EMT.	Vitamin D	17-26	epidermal growth factor receptor	Homo sapiens	68-72
32183160-11	2020	We conclude that vitamin D sufficiency portends increased PFS among EGFR-mutant LUAD patients that receive EGFR TKIs, and that vitamin D signaling maintains drug efficacy in this specific patient subset by opposing EMT.	Vitamin D	17-26	epidermal growth factor receptor	Homo sapiens	107-111
32167486-0	2020	Vitamin D levels are prognostic factors for connective tissue disease associated interstitial lung disease (CTD-ILD).	Vitamin D	0-9	CTD	Homo sapiens	108-111
32167486-1	2020	OBJECTIVE: Vitamin D deficiency was associated with CTD-ILD and reduced lung function.	Vitamin D	11-20	CTD	Homo sapiens	52-55
32167486-3	2020	RESULTS: The CTD-ILD patients had lower Vitamin D level(P<0.05).	Vitamin D	40-49	CTD	Homo sapiens	13-16
32167486-4	2020	Among patients with CTD-ILD who have improved lung function after treatment, elevation of Vitamin D level was positively associated with DeltaFVC (%), DeltaFEV1(%) and DeltaDLCO-SB (%).	Vitamin D	90-99	CTD	Homo sapiens	20-23
32167486-7	2020	CONCLUSIONS: Vitamin D level was lower in patients with CTD-ILD and associated with poor prognosis.	Vitamin D	13-22	CTD	Homo sapiens	56-59
31984787-6	2020	Thus, a new hypothesis is emerging, indicating that vitamin D deficiency may impair the intestinal innate immunity, including downregulation of Paneth cell defensins, leading to bacterial translocation, endotoxemia, systemic inflammation, insulin resistance, and hepatic steatosis.	Vitamin D	52-61	insulin	Homo sapiens	239-246
32147032-0	2020	The effect of intramuscular megadose of vitamin D injections on E-selectin, CRP and biochemical parameters in vitamin D-deficient patients with type-2 diabetes mellitus: A randomized controlled trial.	Vitamin D	40-49	C-reactive protein	Homo sapiens	76-79
32147032-6	2020	RESULTS: Vitamin D resulted in significant reductions in CRP(P = 0.01) and gamma glutamyl transferase (GGT) levels(P = 0.03) and significant increases in 25(OH)D concentrations(P = 0.01) in the intervention group compared with the control.	Vitamin D	9-18	C-reactive protein	Homo sapiens	57-60
32147032-9	2020	CONCLUSION: Vitamin D had beneficial effects on the levels of CRP, serum 25(OH)D and GGT among vitamin D deficient patients with T2DM.	Vitamin D	12-21	C-reactive protein	Homo sapiens	62-65
31996592-5	2020	Vitamin D supplementation decreases parathyroid hormone (PTH) levels and high levels of 25-hydroxyvitamin D may be required for maximal suppression.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	36-55
31996592-5	2020	Vitamin D supplementation decreases parathyroid hormone (PTH) levels and high levels of 25-hydroxyvitamin D may be required for maximal suppression.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	57-60
31996592-7	2020	The primary reason to use vitamin D in kidney disease remains to lower PTH levels.	Vitamin D	26-35	parathyroid hormone	Homo sapiens	71-74
31705961-2	2020	Previous reports have indicated that Vitamin D (vit.D) affects gene expression and have roles in normal follicular development.	Vitamin D	37-46	vitrin	Homo sapiens	48-51
31734492-13	2020	CONCLUSIONS: Our data confirms that vitamin D is present in the humours of the human eye and that local synthesis/degradation is possible via the ocular CYP27B1 and CYP24A1.	Vitamin D	36-45	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	153-160
30531693-8	2020	CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.	Vitamin D	55-64	insulin receptor substrate 1	Rattus norvegicus	137-142
30531693-8	2020	CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.	Vitamin D	55-64	insulin receptor substrate 1	Rattus norvegicus	143-150
31838171-6	2020	The vitamin D-mediated memory improvement may be accompanied by the suppression of increased hippocampal collapsin response mediator protein-2 (CRMP2) phosphorylation, and the restoration of CRMP2 phosphorylation by okadaic acid (OA) could abolish the beneficial effects of vitamin D.	Vitamin D	4-13	dihydropyrimidinase-like 2	Mus musculus	105-142
31838171-6	2020	The vitamin D-mediated memory improvement may be accompanied by the suppression of increased hippocampal collapsin response mediator protein-2 (CRMP2) phosphorylation, and the restoration of CRMP2 phosphorylation by okadaic acid (OA) could abolish the beneficial effects of vitamin D.	Vitamin D	4-13	dihydropyrimidinase-like 2	Mus musculus	144-149
31838171-6	2020	The vitamin D-mediated memory improvement may be accompanied by the suppression of increased hippocampal collapsin response mediator protein-2 (CRMP2) phosphorylation, and the restoration of CRMP2 phosphorylation by okadaic acid (OA) could abolish the beneficial effects of vitamin D.	Vitamin D	4-13	dihydropyrimidinase-like 2	Mus musculus	191-196
31838171-7	2020	In addition, we found that CRMP2 was associated with NR2B and PSD-95 in 3xTg-AD mice with vitamin D supplementation.	Vitamin D	90-99	dihydropyrimidinase-like 2	Mus musculus	27-32
31838171-8	2020	This CRMP2-NR2B interaction could be disrupted by a TAT-CBD3 peptide or OA, leading to attenuated memory protection in vitamin D-treated 3xTg-AD mice.	Vitamin D	119-128	dihydropyrimidinase-like 2	Mus musculus	5-10
31838171-9	2020	Therefore, CRMP2 may be involved in vitamin D-mediated memory improvement in AD.	Vitamin D	36-45	dihydropyrimidinase-like 2	Mus musculus	11-16
31823044-6	2020	In addition, the potentially adverse effects of PTH-lowering measures, such as active vitamin D and calcimimetics, must be taken into account.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	48-51
32056782-1	2020	INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D.	Vitamin D	14-23	D-box binding PAR bZIP transcription factor	Homo sapiens	113-116
32056782-1	2020	INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D.	Vitamin D	57-66	D-box binding PAR bZIP transcription factor	Homo sapiens	113-116
32184917-8	2020	Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1.	Vitamin D	29-38	nitric oxide synthase 2, inducible	Mus musculus	108-139
32184917-8	2020	Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1.	Vitamin D	29-38	nitric oxide synthase 2, inducible	Mus musculus	141-145
32184917-8	2020	Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1.	Vitamin D	29-38	heme oxygenase 1	Mus musculus	201-224
32184917-9	2020	By contrast, vitamin D deficiency attenuated alcohol-induced upregulation of hepatic antioxidant enzyme genes, such as superoxide dismutase (sod) 1 and gshpx.	Vitamin D	13-22	superoxide dismutase 1, soluble	Mus musculus	119-147
32093657-0	2020	The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial.	Vitamin D	15-24	calcitonin related polypeptide alpha	Homo sapiens	71-102
32093657-0	2020	The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial.	Vitamin D	15-24	calcitonin related polypeptide alpha	Homo sapiens	104-108
32093657-8	2020	Moreover, after controlling for baseline levels, and other variables using ANCOVA, CGRP level was appeared to be significantly lower following vitamin D supplementation (153.26 (133.03-173.49) ng/L) than the patients in the placebo arm (188.35 (167.15-209.54) ng/L) (P value = 0.022).	Vitamin D	143-152	calcitonin related polypeptide alpha	Homo sapiens	83-87
32093657-9	2020	CONCLUSION: According to the current findings, vitamin D supplementation in episodic migraineurs, particularly in those with migraine with aura, may potentially improve migraine headache characteristics and disability probably through attenuating CGRP levels.	Vitamin D	47-56	calcitonin related polypeptide alpha	Homo sapiens	247-251
32185236-8	2020	Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR.	Vitamin D	43-52	insulin	Homo sapiens	121-128
32148490-1	2020	Background: The purpose of the current study is to determine PTH reference values in vitamin-D-replete Lebanese adults using 2nd and 3rd generation PTH assays and to look at the factors that affect PTH variations.	Vitamin D	85-94	parathyroid hormone	Homo sapiens	61-64
32056400-3	2020	Therefore, we aimed to investigate if the sufficient serum vit D level is helpful to control disease activity in RA patients treated with interleukin (IL)-6 receptor antibody tocilizumab.	Vitamin D	59-64	interleukin 6 receptor	Homo sapiens	138-165
32056400-14	2020	CONCLUSION: RA patients treated with IL-6 antibody show a better response when they have sufficient serum vit D.	Vitamin D	106-111	interleukin 6	Homo sapiens	37-41
32069873-7	2020	Moreover, vitamin D showed a negative independent association with BMI, diastolic blood pressure and serum insulin levels.	Vitamin D	10-19	insulin	Homo sapiens	107-114
32069873-9	2020	It also shows that vitamin D deficiency, a common condition in obesity, has independent associations with higher BMI, diastolic blood pressure and serum insulin levels.	Vitamin D	19-28	insulin	Homo sapiens	153-160
32024097-7	2020	CONCLUSIONS: Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance.	Vitamin D	17-26	insulin	Homo sapiens	252-259
31619748-6	2020	Phosphate levels were higher low VD level patients: age &lt;50 years, CYP27B1 + 2838CC genotype and non-European ancestry were predictors.	Vitamin D	33-35	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	70-77
31619748-7	2020	PTH levels were border-line higher in TDF patients: non-European ancestry, females, TDF, VD levels &lt; 30 ng/mL and SLC28A2-124CT/TT and ABCC2-24CC were predictors.	Vitamin D	89-91	parathyroid hormone	Homo sapiens	0-3
31982424-11	2020	Also, Vitamin D analogue significantly increased expression of Nrf2 and its downstream effectors (HO-1 and GSH), improved serum levels of total 25-hydroxyvitamin D and calcium, decreased neuro-inflammation and Amyloid beta load as well as hyperphosphorylation of MAPK-38, ERK1/2 and tau proteins were also observed.	Vitamin D	6-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
32231092-1	2020	Optimal vitamin D status has commonly been defined as the level of 25-hydroxyvitamin D (25(OH)D) at which parathyroid hormone (PTH) concentrations would be maximally suppressed, represented by an observed minimum plateau.	Vitamin D	8-17	parathyroid hormone	Homo sapiens	106-125
32231092-1	2020	Optimal vitamin D status has commonly been defined as the level of 25-hydroxyvitamin D (25(OH)D) at which parathyroid hormone (PTH) concentrations would be maximally suppressed, represented by an observed minimum plateau.	Vitamin D	8-17	parathyroid hormone	Homo sapiens	127-130
32231092-6	2020	Mean PTH concentrations for Brazilian women with vitamin D deficiency (<25 nmol/L) were significantly higher compared to those with vitamin D insufficiency (25-49.9 nmol/L) (p < 0.01), vitamin D adequacy (50-74.9 nmol/L) (p < 0.01) and those with optimal vitamin D status (>75 nmol/L) (p < 0.001).	Vitamin D	49-58	parathyroid hormone	Homo sapiens	5-8
32213226-8	2020	The prevalence of abdominal obesity (66% vs. 49%), generalized obesity (80% vs. 64%), metabolic syndrome (45% vs. 37%), and insulin resistance (38% vs. 27%) was significantly higher in those with vitamin D deficiency compared to those without respectively.	Vitamin D	196-205	insulin	Homo sapiens	124-131
32188088-12	2020	In patients with serum vitamin D below 25 ng/mL, vitamin D seasonal change correlated with CRP and prealbumin change.	Vitamin D	23-32	C-reactive protein	Homo sapiens	91-94
32188088-12	2020	In patients with serum vitamin D below 25 ng/mL, vitamin D seasonal change correlated with CRP and prealbumin change.	Vitamin D	49-58	C-reactive protein	Homo sapiens	91-94
31255367-1	2020	INTRODUCTION AND OBJECTIVES: Previous observational studies have suggested that low vitamin D status is associated with high circulating C-reactive protein levels, as well as other plasma inflammatory cytokines.	Vitamin D	84-93	C-reactive protein	Homo sapiens	137-155
32150881-5	2020	Vitamin D inhibited oxidative DNA/RNA damage and membrane damage; and stimulated superoxide dismutase expression and p53 promoter activity in melanoma cells.	Vitamin D	0-9	tumor protein p53	Homo sapiens	117-120
32150881-7	2020	We conclude that vitamin D is beneficial to melanoma cells through the inhibition of oxidative DNA/RNA damage, membrane damage, and the expression of inflammatory, angiogenic and ECM remodeling proteins; and the stimulation of superoxide dismutase expression and p53 promoter activity.	Vitamin D	17-26	tumor protein p53	Homo sapiens	263-266
32724281-11	2020	Tumor necrosis factor alpha inhibitors were associated with higher serum vitamin D levels in CD and UC, and ileal involvement, ileal and ileocolonic resection with lower levels.	Vitamin D	73-82	tumor necrosis factor	Homo sapiens	0-27
31053513-9	2020	CONCLUSION: In the DALI vitamin D trial, supplementation with 1600 IU vitamin D3/day achieved vitamin D sufficiency in virtually all pregnant women and a small effect in FPG at 35-37 weeks.	Vitamin D	24-33	DNMT1-associated long intergenic non-coding RNA	Homo sapiens	19-23
31053513-9	2020	CONCLUSION: In the DALI vitamin D trial, supplementation with 1600 IU vitamin D3/day achieved vitamin D sufficiency in virtually all pregnant women and a small effect in FPG at 35-37 weeks.	Vitamin D	70-79	DNMT1-associated long intergenic non-coding RNA	Homo sapiens	19-23
31241425-8	2020	After UM, the significant up-regulation of TNF-alpha and hsa-miR-155 and down-regulation of IL-1beta were observed in the group with vitamin D supplementation.	Vitamin D	133-142	tumor necrosis factor	Homo sapiens	43-52
31241425-8	2020	After UM, the significant up-regulation of TNF-alpha and hsa-miR-155 and down-regulation of IL-1beta were observed in the group with vitamin D supplementation.	Vitamin D	133-142	interleukin 1 beta	Homo sapiens	92-100
31743490-1	2020	X-linked hypophosphatemia (XLH), caused by a loss-of-function mutation in the phosphate regulating gene with homology to endopeptidase located on the X chromosome (PHEX), is the most common form of vitamin D-resistant rickets.	Vitamin D	198-207	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	164-168
31705962-3	2020	Vitamin D deficiency resulted in reduced levels of phosphorylated mTOR, and suppressed mTOR-dependent phosphorylation of 4E-BP1 and p70-S6K, implying a decrease in activity of the protein synthesis machinery.	Vitamin D	0-9	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	121-127
31705962-5	2020	Vitamin D deficiency or insufficiency also led to a decrease in expression of both myosin and actin-associated proteins (Myh1, Myh2, Myh7, Tnnc1& Tnnt1), which are essential for generation of the mechanical force needed for muscle contraction.	Vitamin D	0-9	troponin C1, slow skeletal and cardiac type	Rattus norvegicus	139-144
31953161-6	2020	In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.	Vitamin D	70-79	insulin	Homo sapiens	93-100
31972209-0	2020	The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway.	Vitamin D	61-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-128
31982803-2	2020	We hypothesized that vitamin D binding protein (DBP), as a transporter of vitamin D, might also influence CAF and the overall metabolic risk.	Vitamin D	21-30	D-box binding PAR bZIP transcription factor	Homo sapiens	48-51
31701851-0	2020	A single injection of vitamin D3 improves insulin sensitivity and beta-cell function but not muscle damage or the inflammatory and cardiovascular responses to an acute bout of resistance exercise in vitamin D-deficient resistance-trained males.	Vitamin D	22-31	insulin	Homo sapiens	42-49
31701851-9	2020	A single injection of vitamin D3 improved insulin resistance and beta-cell function following RE in previously vitamin D-deficient resistance-trained males.	Vitamin D	22-31	insulin	Homo sapiens	42-49
32318358-10	2020	It was found that reduction in serum Vitamin D level to <10.25 ng/mL results in a surge of serum PTH.	Vitamin D	37-46	parathyroid hormone	Homo sapiens	97-100
32042037-2	2020	A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS.	Vitamin D	124-133	D-box binding PAR bZIP transcription factor	Homo sapiens	148-151
32042037-2	2020	A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS.	Vitamin D	124-133	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	153-160
32033527-1	2020	BACKGROUND: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-gamma coactivator 1alpha (PGC-1alpha) and irisin levels and these improvements may reduce insulin resistance (IR).	Vitamin D	12-21	PPARG coactivator 1 alpha	Homo sapiens	75-104
32033527-1	2020	BACKGROUND: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-gamma coactivator 1alpha (PGC-1alpha) and irisin levels and these improvements may reduce insulin resistance (IR).	Vitamin D	12-21	PPARG coactivator 1 alpha	Homo sapiens	106-116
32033527-1	2020	BACKGROUND: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-gamma coactivator 1alpha (PGC-1alpha) and irisin levels and these improvements may reduce insulin resistance (IR).	Vitamin D	12-21	insulin	Homo sapiens	170-177
32013954-10	2020	However, vitamin D supplementation demonstrated positive effects on transferrin saturation [mean difference (MD): 1.54; 95% CI: 0.31, 2.76; P = 0.01] and iron status [std.	Vitamin D	9-18	transferrin	Homo sapiens	68-79
31668375-11	2020	Rates of changes in PTH and phosphate levels increased modestly and without marked acceleration around the same time, with modest deceleration immediately before ESKD, when use of active vitamin D and phosphate binders increased.	Vitamin D	187-196	parathyroid hormone	Homo sapiens	20-23
31642155-5	2020	Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	72-79
31642155-5	2020	Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	94-98
31642155-5	2020	Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry.	Vitamin D	0-9	toll like receptor 2	Homo sapiens	162-166
31871108-0	2020	Effect of Vitamin D on Relapse-Free Survival in a Subgroup of Patients with p53 Protein-Positive Digestive Tract Cancer: A Post Hoc Analysis of the AMATERASU Trial.	Vitamin D	10-19	tumor protein p53	Homo sapiens	76-79
31871108-7	2020	In a subgroup of patients with p53-positive cancer (n = 226), 5-year RFS was 79% in the vitamin D group, which was significantly higher than the 57% in the placebo group (HR, 0.52; 95% confidence interval, 0.31-0.88; P = 0.02).	Vitamin D	88-97	tumor protein p53	Homo sapiens	31-34
31871108-8	2020	In the subgroup of patients with p53-negative cancer, 5-year RFS in the vitamin D group versus placebo group was 72% versus 84% (not significantly different), respectively.	Vitamin D	72-81	tumor protein p53	Homo sapiens	33-36
31871108-11	2020	CONCLUSIONS: These results generate a hypothesis that vitamin D supplementation may improve RFS in patients with p53-positive digestive tract cancer.	Vitamin D	54-63	tumor protein p53	Homo sapiens	113-116
32024097-5	2020	RESULTS: Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status.	Vitamin D	23-32	insulin	Homo sapiens	259-266
32024097-5	2020	RESULTS: Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	289-292
30649593-9	2020	After adjustment for baseline values, season, sun exposure, and dietary vitamin D intake, there was a greater increase in adiponectin (beta[95%CI] = 13.7[2.0, 25.5], p = 0.02) and leptin (beta[95%CI] = 22.3[3.8, 40.9], p = 0.02) in the vitamin D group compared with placebo.	Vitamin D	72-81	adiponectin, C1Q and collagen domain containing	Homo sapiens	122-133
30649593-9	2020	After adjustment for baseline values, season, sun exposure, and dietary vitamin D intake, there was a greater increase in adiponectin (beta[95%CI] = 13.7[2.0, 25.5], p = 0.02) and leptin (beta[95%CI] = 22.3[3.8, 40.9], p = 0.02) in the vitamin D group compared with placebo.	Vitamin D	236-245	adiponectin, C1Q and collagen domain containing	Homo sapiens	122-133
30649593-11	2020	CONCLUSIONS: Vitamin D may increase adiponectin and leptin concentrations in overweight/obese and vitamin D-deficient adults.	Vitamin D	13-22	adiponectin, C1Q and collagen domain containing	Homo sapiens	36-47
31982424-3	2020	The present study was conducted to evaluate the effects of active vitamin D analogue, Maxacalcitol, on Keap1-Nrf2 signaling pathway in experimental Alzheimer"s disease in rats.	Vitamin D	66-75	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113
31721480-11	2020	Vitamin D repletion attenuated elevated expression of beige adipose cell biomarkers (UCP-1, CD137, Tmem26, and Tbx1) as well as aberrant expression of molecules implicated in adipose tissue browning (Cox2, Pgf2alpha, and NF-kappaB pathway) in inguinal white adipose tissue in Ctns-/- mice.	Vitamin D	0-9	tumor necrosis factor receptor superfamily, member 9	Mus musculus	92-97
32053841-2	2020	The study endeavors to comprehend the differential impact of insulin sensitizers vs. anti-androgen on serum leptin levels among women with PCOS rendered vitamin D replete with high VD oral supplement.	Vitamin D	153-162	insulin	Homo sapiens	61-68
31721480-11	2020	Vitamin D repletion attenuated elevated expression of beige adipose cell biomarkers (UCP-1, CD137, Tmem26, and Tbx1) as well as aberrant expression of molecules implicated in adipose tissue browning (Cox2, Pgf2alpha, and NF-kappaB pathway) in inguinal white adipose tissue in Ctns-/- mice.	Vitamin D	0-9	transmembrane protein 26	Mus musculus	99-105
31629064-0	2020	Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression.	Vitamin D	27-36	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	95-102
31672717-10	2020	Our results showed that median plasma endotoxin and zonulin decreased with increasing serum levels of vitamin D categories (p=0.001) in the overall study population.	Vitamin D	102-111	haptoglobin	Homo sapiens	52-59
31672717-11	2020	Multivariate binary logistic regression analyses showed a significant association between the plasma endotoxin (OR 0.12, 95% CI 0.03 to 0.52) and zonulin (OR 0.91, 95% CI 0.87 to 0.99) levels with serum levels of vitamin D categories in the overall population.	Vitamin D	213-222	haptoglobin	Homo sapiens	146-153
31651575-7	2020	Secondary analyses suggest that the effect of Vitamin D on post-MVC pain outcomes may be influenced by genetic variation in IL-10 and NLRP3.	Vitamin D	46-55	NLR family pyrin domain containing 3	Homo sapiens	134-139
32019160-3	2020	The results show that epididymal fat Mcp-1 and Rantes mRNA levels, which were higher in obese mice compared with lean mice, were significantly down-regulated by vitamin D supplementation.	Vitamin D	161-170	mast cell protease 1	Mus musculus	37-42
32141817-0	2020	Vitamin D decreases CD40L gene expression in ulcerative colitis patients: A randomized, double-blinded, placebo-controlled trial.	Vitamin D	0-9	CD40 ligand	Homo sapiens	20-25
32141817-3	2020	The aim of the present study was to assess the effect of vitamin D on CD40L gene expression in patients with ulcerative colitis (UC).	Vitamin D	57-66	CD40 ligand	Homo sapiens	70-75
32141817-9	2020	Relative to baseline values, the CD40L gene expression fold change was significantly lower in the vitamin D group compared with the placebo group (median+-interquartile range: 0.34+-0.30 vs 0.43+-1.20, respectively, p=0.016).	Vitamin D	98-107	CD40 ligand	Homo sapiens	33-38
32141817-10	2020	CONCLUSION: The results of this study showed that vitamin D administration in mild-to-moderate UC patients led to the downregulation of the CD40L gene, which is an essential part of inflammatory pathways.	Vitamin D	50-59	CD40 ligand	Homo sapiens	140-145
32019160-3	2020	The results show that epididymal fat Mcp-1 and Rantes mRNA levels, which were higher in obese mice compared with lean mice, were significantly down-regulated by vitamin D supplementation.	Vitamin D	161-170	chemokine (C-C motif) ligand 5	Mus musculus	47-53
31942011-0	2020	Vitamin D/VDR signaling induces miR-27a/b expression in oral lichen planus.	Vitamin D	0-9	microRNA 27a	Homo sapiens	32-39
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	cyclin dependent kinase inhibitor 2A	Mus musculus	264-267
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	superoxide dismutase 1, soluble	Mus musculus	136-140
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	superoxide dismutase 2, mitochondrial	Mus musculus	142-146
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	peroxisome proliferator activated receptor alpha	Mus musculus	164-173
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	dual oxidase 2	Mus musculus	230-235
31942011-7	2020	In the rescue experiments, we confirmed vitamin D and VDR inhibited LPS- or activated CD4+ T cell-induced miR-27a/b reductions in HOKs.	Vitamin D	40-49	microRNA 27a	Homo sapiens	106-113
31942011-8	2020	In sum, our results show that vitamin D/VDR signaling induces miR-27a/b in oral lichen planus.	Vitamin D	30-39	microRNA 27a	Homo sapiens	62-69
31914999-2	2020	Patients with vitamin D deficiency may also be asymptomatic, with normal calcium and elevated PTH concentrations.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	94-97
31998239-1	2019	Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	85-88
31998239-5	2019	DBP has a single binding site for all vitamin D metabolites and has a high affinity for 25OHD and 1,25(OH)2D, thereby creating a large pool of circulating 25OHD, which prevents rapid vitamin D deficiency.	Vitamin D	38-47	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
31998239-5	2019	DBP has a single binding site for all vitamin D metabolites and has a high affinity for 25OHD and 1,25(OH)2D, thereby creating a large pool of circulating 25OHD, which prevents rapid vitamin D deficiency.	Vitamin D	183-192	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
32990626-0	2020	Does vitamin D affect sarcopenia with insulin resistance in aging?	Vitamin D	5-14	insulin	Homo sapiens	38-45
31816443-0	2020	The influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis.	Vitamin D	17-26	insulin like growth factor 1	Homo sapiens	46-51
31816443-1	2020	BACKGROUND: Inconsistencies exist with regard to influence of vitamin D supplementation on IGF-1 levels.	Vitamin D	62-71	insulin like growth factor 1	Homo sapiens	91-96
31816443-3	2020	To address these inconsistencies, this study was conducted to determine the impact of vitamin D supplementation on IGF-1 levels through a systematic review and meta-analysis of randomized controlled trials (RCTs).	Vitamin D	86-95	insulin like growth factor 1	Homo sapiens	115-120
31816443-4	2020	METHODS: A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase for RCTs that investigated the impact of vitamin D intake on circulating IGF-1 levels from inception until June 2019.	Vitamin D	153-162	insulin like growth factor 1	Homo sapiens	185-190
31816443-7	2020	RESULTS: Pooled results from eight studies demonstrated an overall non-significant increase in IGF-1 following vitamin D supplementation (WMD: 4 ng/ml, 95 % CI: -4 to 11).	Vitamin D	111-120	insulin like growth factor 1	Homo sapiens	95-100
31816443-9	2020	The subgroup analyses showed that vitamin D dosage of <=1000 IU/day (WMD: 10 ng/ml) significantly increased IGF-1 compared to the vitamin D dosage of <1000 IU/day (WMD: -1 ng/ml).	Vitamin D	34-43	insulin like growth factor 1	Homo sapiens	108-113
31816443-11	2020	In the epidemiological cohort study, participants under 60 years of age with a higher dietary vitamin D intake had significantly higher IGF-1 levels when compared to those with lower dietary vitamin D intake in second categories.	Vitamin D	94-103	insulin like growth factor 1	Homo sapiens	136-141
31816443-12	2020	CONCLUSION: The main results indicate a non-significant increase in IGF-1 following vitamin D supplementation.	Vitamin D	84-93	insulin like growth factor 1	Homo sapiens	68-73
31816443-13	2020	Additionally, vitamin D dosages of <1000 IU/day and intervention durations of <12 weeks significantly raised IGF-1 levels.	Vitamin D	14-23	insulin like growth factor 1	Homo sapiens	109-114
31892609-3	2020	RESULTS: There was a dose-dependent effect of vitamin D supplementation on serum 25(OH)D, PTH and broad gene expression.	Vitamin D	46-55	parathyroid hormone	Homo sapiens	90-93
31972611-4	2020	We investigated the expression of miR-346 and its 2 target genes, the receptor of vitamin D (VDR), and the tumor necrosis factor-alpha (TNF-alpha), which are known to modulate carcinogenesis.	Vitamin D	82-91	microRNA 346	Homo sapiens	34-41
31729097-2	2020	The present study found that vimentin, a mesenchymal marker, was accordingly upregulated, and E-cadherin, an epithelial marker, was downregulated in RCC patients with low vitamin D status.	Vitamin D	171-180	cadherin 1	Homo sapiens	94-104
31536991-1	2020	BACKGROUND: Studies of serum vitamin D (Vit-D) levels in patients with inflammatory bowel disease (IBD) treated with anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents are scarce.	Vitamin D	29-38	vitrin	Homo sapiens	40-43
31107101-3	2020	OBJECTIVE: To compare the effect of oral vitamin D supplementation with sunlight exposure on serum vitamin D and parathyroid hormone (PTH).	Vitamin D	41-50	parathyroid hormone	Homo sapiens	113-132
31107101-3	2020	OBJECTIVE: To compare the effect of oral vitamin D supplementation with sunlight exposure on serum vitamin D and parathyroid hormone (PTH).	Vitamin D	41-50	parathyroid hormone	Homo sapiens	134-137
31107101-4	2020	METHODS: A computer-based literature search through PubMed, Scopus and Google scholar search engines was conducted until April 2019 to find clinical trials which compared the effect of oral vitamin D supplementation with sunlight exposure on serum vitamin D and PTH.	Vitamin D	190-199	parathyroid hormone	Homo sapiens	262-265
33092508-14	2020	While human LL-37 can be induced by vitamin D, vitamin A induces the expression of resistin-like molecule alpha (RELMalpha) in mice.	Vitamin D	36-45	cathelicidin antimicrobial peptide	Homo sapiens	12-17
30596263-8	2020	The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD).	Vitamin D	69-78	interleukin 6	Homo sapiens	173-186
30596263-8	2020	The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD).	Vitamin D	69-78	vascular cell adhesion molecule 1	Homo sapiens	208-241
30596263-8	2020	The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD).	Vitamin D	69-78	vascular cell adhesion molecule 1	Homo sapiens	243-249
30596263-8	2020	The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD).	Vitamin D	69-78	myeloperoxidase	Homo sapiens	275-290
30596263-8	2020	The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD).	Vitamin D	69-78	superoxide dismutase 1	Homo sapiens	313-333
30596263-8	2020	The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD).	Vitamin D	69-78	superoxide dismutase 1	Homo sapiens	335-338
31536991-1	2020	BACKGROUND: Studies of serum vitamin D (Vit-D) levels in patients with inflammatory bowel disease (IBD) treated with anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents are scarce.	Vitamin D	29-38	tumor necrosis factor	Homo sapiens	122-149
31536991-1	2020	BACKGROUND: Studies of serum vitamin D (Vit-D) levels in patients with inflammatory bowel disease (IBD) treated with anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents are scarce.	Vitamin D	29-38	tumor necrosis factor	Homo sapiens	156-165
33877102-7	2020	Vitamin D had a significant negative correlation with US-CRP (p = 0.026), NLR (p = 0.013) and PLR (p = 0.022).	Vitamin D	0-9	C-reactive protein	Homo sapiens	57-60
32238143-7	2020	The immunmodulatory effects of the active metabolite of vitamin D (alpha-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-beta and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC.	Vitamin D	56-65	immunoglobulin kappa variable 1-22 (pseudogene)	Homo sapiens	67-75
32238143-7	2020	The immunmodulatory effects of the active metabolite of vitamin D (alpha-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-beta and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC.	Vitamin D	56-65	interleukin 6	Homo sapiens	110-114
31187648-8	2020	High-doses of vitamin D (4000 IU), compared with low-dose (1000 IU), and placebo, showed beneficial effects on total testosterone, sex hormone-binding globulin (SHBG) and free androgen index (FAI).	Vitamin D	14-23	sex hormone binding globulin	Homo sapiens	131-159
31187648-8	2020	High-doses of vitamin D (4000 IU), compared with low-dose (1000 IU), and placebo, showed beneficial effects on total testosterone, sex hormone-binding globulin (SHBG) and free androgen index (FAI).	Vitamin D	14-23	sex hormone binding globulin	Homo sapiens	161-165
31187648-9	2020	Vitamin D supplementation at high doses for a period of at least 12 weeks, may lead to improvement in terms of glucose level, insulin sensitivity, hyperlipidemia, and hormonal functionality in PCOS women.	Vitamin D	0-9	insulin	Homo sapiens	126-133
33877102-9	2020	The values of US-CRP, NLR and PLR were significantly higher in the presence of vitamin D deficiency.	Vitamin D	79-88	C-reactive protein	Homo sapiens	17-20
33877102-10	2020	A significant inverse correlation was found between vitamin D levels and US-CRP, NLR and PLR.	Vitamin D	52-61	C-reactive protein	Homo sapiens	76-79
31102703-2	2020	It is widely known that low Vitamin D can lead to increased renal renin and angiotensin II production, consequently elevating blood pressure or development of essential hypertension (EH).	Vitamin D	28-37	renin	Homo sapiens	66-90
32528735-7	2020	Noting that DNA hypomethylation and inappropriate DRB1*1501 expression were observed in MS patient CD4+ T cells, we propose that vitamin D deficiency thwarts epigenetic downregulation of DRB1*1501 and Th17 cell signature genes, and upregulation of Treg cell signature genes, causing dysregulation within the CD4+ T cell compartment.	Vitamin D	129-138	major histocompatibility complex, class II, DR beta 1	Homo sapiens	187-191
32444536-12	2020	Serum level of PTH was a significant risk factor for severe vitamin D deficiency while calcium D supplementation, MET and sunscreen were significant protective factors.	Vitamin D	60-69	parathyroid hormone	Homo sapiens	15-18
32071501-0	2020	Association of Vitamin D and Parathyroid Hormone Levels in Overweight and Obese Adolescents.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	29-48
32528735-7	2020	Noting that DNA hypomethylation and inappropriate DRB1*1501 expression were observed in MS patient CD4+ T cells, we propose that vitamin D deficiency thwarts epigenetic downregulation of DRB1*1501 and Th17 cell signature genes, and upregulation of Treg cell signature genes, causing dysregulation within the CD4+ T cell compartment.	Vitamin D	129-138	major histocompatibility complex, class II, DR beta 1	Homo sapiens	50-54
32528735-7	2020	Noting that DNA hypomethylation and inappropriate DRB1*1501 expression were observed in MS patient CD4+ T cells, we propose that vitamin D deficiency thwarts epigenetic downregulation of DRB1*1501 and Th17 cell signature genes, and upregulation of Treg cell signature genes, causing dysregulation within the CD4+ T cell compartment.	Vitamin D	129-138	CD4 molecule	Homo sapiens	99-102
32528735-7	2020	Noting that DNA hypomethylation and inappropriate DRB1*1501 expression were observed in MS patient CD4+ T cells, we propose that vitamin D deficiency thwarts epigenetic downregulation of DRB1*1501 and Th17 cell signature genes, and upregulation of Treg cell signature genes, causing dysregulation within the CD4+ T cell compartment.	Vitamin D	129-138	CD4 molecule	Homo sapiens	308-311
30932788-0	2020	Strong association between serum Vitamin D and Vaspin Levels, AIP, VAI and liver enzymes in NAFLD patients.	Vitamin D	33-42	serpin family A member 12	Homo sapiens	47-53
30932788-11	2020	The positive correlations between Vaspin levels and vitamin D were found to be remarkably significant in both males and females (r = 0.437; P = 0.004; P &lt; 0.001, r = -0.709, respectively.	Vitamin D	52-61	serpin family A member 12	Homo sapiens	34-40
30932788-13	2020	Partial correlations controlling for age and sex showed that vitamin D is significantly and inversely associated with AIP, VAI, AST, and ALT.	Vitamin D	61-70	solute carrier family 17 member 5	Homo sapiens	128-131
32405353-0	2020	Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats.	Vitamin D	10-19	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	44-48
32405353-10	2020	Results: Administration of vitamin D (4300 IU/kg/week) in a T1DM animal model increased CREB phosphorylation in the hippocampus, but the serum and hippocampal BDNF levels and TrkB and BDNF gene expression did not change significantly.	Vitamin D	27-36	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	175-179
30932788-14	2020	Additionally, vitamin D levels correlated directly with vaspin.	Vitamin D	14-23	serpin family A member 12	Homo sapiens	56-62
33164936-9	2020	Leukocyte TL was significantly higher, while serum 8-OXO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p <  0.001).	Vitamin D	122-131	cyclin dependent kinase inhibitor 2A	Homo sapiens	75-82
31704050-7	2020	At follow-up, 1-year post-supplementation, in the vitamin D group, PTH concentrations continued to remain high (but not significantly different from levels at 6 months), with low normal serum calcium, high normal phosphate, and ALK-P in reference range.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	67-70
31704050-0	2020	Paradoxical Response of Parathyroid Hormone to Vitamin D-Calcium Supplementation in Indian Children.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	24-43
31704050-1	2020	OBJECTIVES: To investigate the effect of oral vitamin D-calcium supplementation on serum intact parathyroid hormone (PTH), calcium, phosphorous, and alkaline phosphatase (ALK-P) concentrations in children with habitually low calcium intakes.	Vitamin D	46-55	parathyroid hormone	Homo sapiens	96-115
31311025-1	2020	OBJECTIVES: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fracture.	Vitamin D	64-73	glucagon	Homo sapiens	78-101
31311025-1	2020	OBJECTIVES: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fracture.	Vitamin D	64-73	glucagon	Homo sapiens	103-108
31311025-7	2020	A positive correlation was observed between serum levels of vitamin D and GLP-1.	Vitamin D	60-69	glucagon	Homo sapiens	74-79
31311025-9	2020	In addition, a significant correlation was determined between decreased vitamin D and GLP-1 levels.	Vitamin D	72-81	glucagon	Homo sapiens	86-91
31691146-15	2020	The treated groups, especially combined vitamin D and exercise group, showed a significant decrease in IL-6, MDA, amyloid beta and tau proteins levels, but on the other hand they showed a significant increase in IL-10, GSH, AChE, dopamine, BDNF and NGF.	Vitamin D	40-49	interleukin 6	Rattus norvegicus	103-107
31734843-5	2020	TNF-alpha markedly increased cytotoxicity for 24, 48, 72 h (p &lt; 0.05) and vitamin D treatment was shown to diminish the cytotoxic effect of TNF-alpha.	Vitamin D	77-86	tumor necrosis factor	Homo sapiens	143-152
32289634-2	2020	The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation.	Vitamin D	100-109	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	155-163
32966919-0	2020	Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: A randomized clinical trial.	Vitamin D	11-20	interleukin 6	Homo sapiens	76-89
33169107-7	2020	On the other hand, furin expression is negatively regulated via 1-alpha-hydroxylase (CYP27B1), that belongs to vitamin-D pathway and controls cellular calcium levels.	Vitamin D	111-120	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	85-92
33169107-9	2020	Thus, we propose a possible synergistic application of melanin and the enzyme CYP27B1 (regulates vitamin D biosynthesis) as a novel strategy to prevent viral entry through the inactivation of furin protease and aid in boosting our immunity at the cellular and humoral levels.	Vitamin D	97-106	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	78-85
31892349-7	2019	RESULTS: Vitamin D levels were significantly lower in PTN mothers.	Vitamin D	9-18	pleiotrophin	Homo sapiens	54-57
31892662-0	2019	Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial.	Vitamin D	0-9	BCL2 like 10	Homo sapiens	72-76
31905893-6	2019	Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-kappaB pathway to decrease CAD progression.	Vitamin D	45-54	nuclear factor kappa B subunit 1	Homo sapiens	95-104
31949415-12	2019	The increase of serum hepcidin levels may be inhibited by effective treatment of anemia with iron supplementation and erythropoietin, and the treatment of secondary hyperparathyroidism with phosphate binders and the active form of vitamin D, which decrease serum parathyroid hormone and fibroblast growth factor-23 levels, and control inflammation to some extent.	Vitamin D	231-240	parathyroid hormone	Homo sapiens	263-282
31849339-0	2019	The relationship between vitamin D and insulin resistance before delivery in advanced maternal age.	Vitamin D	25-34	insulin	Homo sapiens	39-46
31849339-2	2019	We aimed to assess the association of vitamin D levels and insulin resistance (IR) during the late pregnancy in AMA.	Vitamin D	38-47	insulin	Homo sapiens	59-66
31849339-6	2019	RESULTS: Pregnant women in AMA with vitamin D deficiency have higher fasting insulin (14.70(8.76-34.65) and 10.89(7.15-16.12), respectively, P = 0.031) and HOMA-IR indices (1.78(1.07-4.14) and 1.30(0.83-1.89), respectively, P = 0.024) than those with vitamin D non-deficiency.	Vitamin D	36-45	insulin	Homo sapiens	77-84
31847491-9	2019	We hypothesized that genetic and/or environment mTOR hyperactivation, including provocation by vitamin D deficiency, might be a common mechanism controlling the expressivity of most autism predisposition genes and even core symptoms of autism.	Vitamin D	95-104	mechanistic target of rapamycin kinase	Homo sapiens	48-52
32165938-10	2019	Finally a significant negative correlation between serum levels of vitamin D and Pentraxin 3 was found (r = -0.4, P value = 0.01).	Vitamin D	67-76	pentraxin 3	Homo sapiens	81-92
30970352-0	2020	TGF-beta1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms.	Vitamin D	18-27	transforming growth factor beta 1	Homo sapiens	0-9
31713009-5	2020	However, the level of HDL and vitamin-D in the HAM/TSP subjects were lower than HSs (P = 0.01 and P = 0.006, respectively).	Vitamin D	30-39	thrombospondin 1	Homo sapiens	51-54
31713009-10	2020	It"s more likely that HAM/TSP patients have an imbalanced lipid profile and low levels of vitamin D and may represent a potentially useful target for intervention in HTLV-1 associated diseases.	Vitamin D	90-99	thrombospondin 1	Homo sapiens	26-29
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Vitamin D	124-133	tumor necrosis factor	Homo sapiens	29-38
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Vitamin D	124-133	interleukin 6	Homo sapiens	50-54
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Vitamin D	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
33860776-3	2020	RESULTS: The literature reports that vitamin D has immunomodulatory and anti-inflammatory effects.It reduces the expression of cytokines such as IL-6, TNF-alpha and INF-gamma, regulates the activity of T helper lymphocytes, and other elements of the immune system at the molecular level.	Vitamin D	37-46	interleukin 6	Homo sapiens	145-149
33860776-3	2020	RESULTS: The literature reports that vitamin D has immunomodulatory and anti-inflammatory effects.It reduces the expression of cytokines such as IL-6, TNF-alpha and INF-gamma, regulates the activity of T helper lymphocytes, and other elements of the immune system at the molecular level.	Vitamin D	37-46	tumor necrosis factor	Homo sapiens	151-160
32844632-0	2020	[Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region].	Vitamin D	21-30	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	42-49
32844632-3	2020	OBJECTIVE: To evaluate the relationship between vitamin D status and polymorphisms of the genes encoding enzymes of the vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) in patients with MS. MATERIAL AND METHODS: Caucasians born and living in the Altai region of the Russian Federation, 90 patients with relapsing-remitting MS and 87 volunteers without MS took part in the study.	Vitamin D	48-57	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	141-148
32844632-3	2020	OBJECTIVE: To evaluate the relationship between vitamin D status and polymorphisms of the genes encoding enzymes of the vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) in patients with MS. MATERIAL AND METHODS: Caucasians born and living in the Altai region of the Russian Federation, 90 patients with relapsing-remitting MS and 87 volunteers without MS took part in the study.	Vitamin D	120-129	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	141-148
32844632-9	2020	CONCLUSION: The high prevalence of vitamin D deficiency in patients with MS may be associated with the genetically determined features of CYP27B1.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	138-145
31704050-8	2020	CONCLUSIONS: In children who are vitamin D sufficient but with habitually low dietary calcium intake, vitamin D-calcium supplementation paradoxically and significantly increased serum PTH concentrations with no apparent effect on other bone biochemistry.	Vitamin D	102-111	parathyroid hormone	Homo sapiens	184-187
32099860-8	2020	Vitamin D was positively correlated with CRP, ESR level, the BASFI, and the BASMI.	Vitamin D	0-9	C-reactive protein	Homo sapiens	41-44
31866999-8	2019	In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion.	Vitamin D	13-22	NLR family pyrin domain containing 3	Homo sapiens	48-53
31830090-1	2019	Vitamin D deficiency is highly prevalent worldwide, and vitamin D-binding protein (DBP) a major regulator of serum vitamin D levels.	Vitamin D	56-65	D-box binding PAR bZIP transcription factor	Homo sapiens	83-86
31819048-0	2019	Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	106-115
31824158-5	2019	Antibodies (Ab) against the peritoneum-glycoprotein M6A (GPM6A) Ab were conjugated with vitamin D nanoliposomes.	Vitamin D	88-97	glycoprotein m6a	Mus musculus	28-55
31824158-5	2019	Antibodies (Ab) against the peritoneum-glycoprotein M6A (GPM6A) Ab were conjugated with vitamin D nanoliposomes.	Vitamin D	88-97	glycoprotein m6a	Mus musculus	57-62
31748273-5	2019	It has been assumed that cutaneous vitamin D is transported into the circulation by vitamin D binding protein (DBP), but experimental evidence is lacking.	Vitamin D	35-44	D site albumin promoter binding protein	Mus musculus	111-114
31748273-8	2019	As controls, DBP+/+ animals were vitamin D depleted and made equally hypocalcemic.	Vitamin D	33-42	D site albumin promoter binding protein	Mus musculus	13-16
31748273-10	2019	Intravenous injection of small amounts of recombinant DBP to the vitamin D-deficient DBP-/- mice restored the response to UV light.	Vitamin D	65-74	D site albumin promoter binding protein	Mus musculus	54-57
31748273-10	2019	Intravenous injection of small amounts of recombinant DBP to the vitamin D-deficient DBP-/- mice restored the response to UV light.	Vitamin D	65-74	D site albumin promoter binding protein	Mus musculus	85-88
31748273-11	2019	These results demonstrate a requirement for DBP to utilize cutaneously produced vitamin D.	Vitamin D	80-89	D site albumin promoter binding protein	Mus musculus	44-47
31520221-0	2019	Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population.	Vitamin D	72-81	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	30-37
31112659-1	2019	Vitamin D plays an important role in insulin secretion.	Vitamin D	0-9	insulin	Homo sapiens	37-44
31112659-2	2019	As the enzyme that initiates degradation of the active metabolite of vitamin D (1,25-(OH)2 vitamin D), 24-hydroxylase encoded by CYP24A1 may be associated with insulin secretion.	Vitamin D	69-78	insulin	Homo sapiens	160-167
31112659-11	2019	Increased copy number of CYP24A1 is associated with not only vitamin D deficiency but also increased serum insulin.	Vitamin D	61-70	insulin	Homo sapiens	107-114
31112659-14	2019	Increased copy number of CYP24A1 was associated with increased serum concentration of insulin independent of age, BMI, and vitamin D status.	Vitamin D	123-132	insulin	Homo sapiens	86-93
31381132-0	2019	Severe vitamin D deficiency associated with BRAF mutated melanoma.	Vitamin D	7-16	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	44-48
31398293-0	2019	Contribution of CYP27B1 and CYP24A1 Genetic Variations to the Incidence of Acute Coronary Syndrome and to Vitamin D Serum Level.	Vitamin D	106-115	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	16-23
31699704-9	2019	Vitamin D resulted in 8.2% higher IL-6 (95% CI, 1.5%-15.3%; adjusted P = 0.02), but TNFR2 and hsCRP did not.	Vitamin D	0-9	interleukin 6	Homo sapiens	34-38
31548051-1	2019	The objective of this study was to evaluate expression of a cluster of genes encoding beta-defensin antimicrobial peptides in neutrophils of postpartum cows in relation to prepartum dietary cation-anion difference (DCAD), vitamin D, and postpartum disease.	Vitamin D	222-231	LOC100296173	Bos taurus	86-99
31522253-0	2019	Effects of Elevated Parathyroid Hormone Levels on Muscle Health, Postural Stability and Quality of Life in Vitamin D-Insufficient Healthy Women: A Cross-Sectional Study.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	20-39
32021127-2	2019	This study explored the potential relationship between serum vitamin D levels and SAP.	Vitamin D	61-70	SH2 domain containing 1A	Homo sapiens	82-85
32021127-7	2019	Compared to the patients without SAP, patients with SAP had significantly lower vitamin D levels (P = 0.023).	Vitamin D	80-89	SH2 domain containing 1A	Homo sapiens	52-55
32021127-8	2019	The incidence of SAP was significantly higher in patients with vitamin D deficiency than in those with vitamin D insufficiency or sufficiency (21.2% vs 16.2% & 9.5%, P = 0.006).	Vitamin D	63-72	SH2 domain containing 1A	Homo sapiens	17-20
32021127-8	2019	The incidence of SAP was significantly higher in patients with vitamin D deficiency than in those with vitamin D insufficiency or sufficiency (21.2% vs 16.2% & 9.5%, P = 0.006).	Vitamin D	103-112	SH2 domain containing 1A	Homo sapiens	17-20
32021127-9	2019	After adjusting for confounders, vitamin D deficiency and insufficiency were independently associated with SAP (OR = 3.034, 95% CI = 1.207-7.625, P = 0.018; OR = 1.921, 95% CI = 1.204-3.066, P = 0.006, respectively).	Vitamin D	33-42	SH2 domain containing 1A	Homo sapiens	107-110
32021127-10	2019	In multiple-adjusted spline regression, vitamin D levels showed a linear association with the risk of SAP (P < 0.001 for linearity).	Vitamin D	40-49	SH2 domain containing 1A	Homo sapiens	102-105
32021127-11	2019	Conclusion: Reduced vitamin D is a potential risk factor of in-hospital SAP, which can help clinicians identify high-risk SAP patients.	Vitamin D	20-29	SH2 domain containing 1A	Homo sapiens	72-75
32021127-11	2019	Conclusion: Reduced vitamin D is a potential risk factor of in-hospital SAP, which can help clinicians identify high-risk SAP patients.	Vitamin D	20-29	SH2 domain containing 1A	Homo sapiens	122-125
31548051-6	2019	The mRNA transcripts of beta-defensin genes were quantified by real-time PCR, and data were analyzed with a general linear mixed model to test for fixed effects and interactions of day, level of DCAD, source of vitamin D, and incidence of disease.	Vitamin D	211-220	LOC100296173	Bos taurus	24-37
31215092-0	2019	Effect of vitamin D supplementation on total and free 25 hydroxyvitamin D and parathyroid hormone.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	78-97
31215092-9	2019	There was a progressive decrease in serum PTH with increasing vitamin D doses and the per cent change was similar for F25D and T25D.	Vitamin D	62-71	parathyroid hormone	Homo sapiens	42-45
29883217-1	2019	Aims: Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes.	Vitamin D	39-48	insulin	Homo sapiens	205-212
31470109-2	2019	Keratinocytes express both 25-hydroxylase (CYP27A1 and CYP2R1) and 1alpha-hydroxylase (CYP27B1), critical enzymes involved in active vitamin D synthesis.	Vitamin D	133-142	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	87-94
31467426-7	2019	Treatment with active vitamin D (calcitriol, CAL) and its analogs reduced the protein expression of alpha-smooth muscle actin (alpha-SMA) in mHSC.	Vitamin D	22-31	actin alpha 1, skeletal muscle	Homo sapiens	127-136
31574299-6	2019	We sought to determine if hydroxylation of 25(OH)D by CYP27B1 contributes to non-genomic activity of vitamin D by altering the redox-dependent state of the mitochondria in benign prostate epithelial cells.	Vitamin D	101-110	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	54-61
31702812-0	2019	BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D-deficient mice.	Vitamin D	91-100	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	80-87
31702812-4	2019	The expression levels of surface molecules of DCs, including integrin alpha-X and T-lymphocyte activation antigen CD86, were significantly increased by BCG in the vitamin D-deficient mice model group compared with the control group, while those of T-lymphocyte activation antigen CD80, major histocompatibility complex class I and major histocompatibility complex class II were significantly decreased.	Vitamin D	163-172	CD80 antigen	Mus musculus	248-284
31702812-6	2019	In addition, the levels of IL-4, IL-6 and IL-10 in the BMDCs from the vitamin D-deficient mice were significantly decreased compared with the control mice, while the levels of tumor necrosis factor-alpha, IL-5, IL-2, IL-12 and interferon-gamma were significantly increased.	Vitamin D	70-79	interleukin 6	Mus musculus	33-37
31702812-6	2019	In addition, the levels of IL-4, IL-6 and IL-10 in the BMDCs from the vitamin D-deficient mice were significantly decreased compared with the control mice, while the levels of tumor necrosis factor-alpha, IL-5, IL-2, IL-12 and interferon-gamma were significantly increased.	Vitamin D	70-79	interleukin 10	Mus musculus	42-47
31702812-6	2019	In addition, the levels of IL-4, IL-6 and IL-10 in the BMDCs from the vitamin D-deficient mice were significantly decreased compared with the control mice, while the levels of tumor necrosis factor-alpha, IL-5, IL-2, IL-12 and interferon-gamma were significantly increased.	Vitamin D	70-79	interferon gamma	Mus musculus	227-243
31824492-3	2019	Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	18-58
32109213-2	2019	The objective of the study was to determine the association between maternal vitamin D and adiponectin status with the anthropometrical measures of newborns, and bone health status measured by Quantitative Ultrasound (QUS) at birth.	Vitamin D	77-86	adiponectin, C1Q and collagen domain containing	Homo sapiens	91-102
32173804-10	2019	Vitamin D levels were negatively correlated with waist circumference (p=0.019, r=-0.13), systolic Blood pressure (p=0.04, r=-0.26), triglyceride level (p=0.025, r= -0.3), insulin (p=0.01, r=-0.34) and HOMA-IR (p=0.035, r=-0.29).	Vitamin D	0-9	insulin	Homo sapiens	171-178
31775746-0	2019	Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-beta/Smad2/3-mediated epithelial-mesenchymal transition.	Vitamin D	0-9	SMAD family member 2	Mus musculus	109-116
31775746-20	2019	CONCLUSION: Vitamin D deficiency exacerbates BLM-induced pulmonary fibrosis partially through aggravating TGF-beta/Smad2/3-mediated EMT in the lungs.	Vitamin D	12-21	SMAD family member 2	Mus musculus	115-122
31296588-0	2019	Effects of vitamin D supplementation on cognitive function and blood Abeta-related biomarkers in older adults with Alzheimer"s disease: a randomised, double-blind, placebo-controlled trial.	Vitamin D	11-20	amyloid beta precursor protein	Homo sapiens	69-74
31296588-8	2019	CONCLUSIONS: Daily oral vitamin D supplementation (800 IU/day) for 12 months may improve cognitive function and decrease Abeta-related biomarkers in elderly patients with AD.	Vitamin D	24-33	amyloid beta precursor protein	Homo sapiens	121-126
31612340-9	2019	Vitamin D restored tight junction ZO-1 and claudin 2.	Vitamin D	0-9	claudin 2	Homo sapiens	43-52
31612340-10	2019	In addition, vitamin D decreased TNFalpha expression and prevented the disruption of ZO-1 in injured organoids.	Vitamin D	13-22	tumor necrosis factor	Homo sapiens	33-41
31824492-3	2019	Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	60-64
31824492-6	2019	Activating the CAMP pathway using Vitamin D in hMDM1 resulted in a cathelicidin-mediated-Leishmania restriction.	Vitamin D	34-43	cathelicidin antimicrobial peptide	Homo sapiens	15-19
31731651-7	2019	Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p &lt; 0.001).	Vitamin D	0-9	C-reactive protein	Homo sapiens	77-95
31731695-9	2019	Bone mRNA levels for vitamin D metabolising enzymes CYP27B1 and CYP24A1 were measured by qRT-PCR.	Vitamin D	21-30	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	52-59
31731651-7	2019	Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p &lt; 0.001).	Vitamin D	0-9	C-reactive protein	Homo sapiens	97-100
31651513-16	2019	VD may regulate the formation and differentiation of adipocytes through the VDR and PPARgamma pathways and participate in the occurrence of GDM.	Vitamin D	0-2	peroxisome proliferator activated receptor gamma	Homo sapiens	84-93
31651513-12	2019	VDR mRNA levels positively correlated with the pre-pregnancy body mass index (BMI), pre-delivery BMI, fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), and PPARgamma mRNA while it negatively correlated with the VD and the adiponectin levels (r = 0.395, 0.336, 0.240, 0.190, 0.235, -0.350, -0.294, respectively, P &lt; 0.05).	Vitamin D	0-2	peroxisome proliferator activated receptor gamma	Homo sapiens	197-206
31723229-0	2019	The Vitamin D status is associated with serum C-reactive protein and adhesion molecules in patients with renal cell carcinoma.	Vitamin D	4-13	C-reactive protein	Homo sapiens	46-64
31723229-2	2019	This study investigated the association of vitamin D status with serum C-reactive protein (CRP) and adhesion molecules among RCC patients.	Vitamin D	43-52	C-reactive protein	Homo sapiens	71-89
31723229-2	2019	This study investigated the association of vitamin D status with serum C-reactive protein (CRP) and adhesion molecules among RCC patients.	Vitamin D	43-52	C-reactive protein	Homo sapiens	91-94
31689953-1	2019	The results of epidemiological and several interventional studies suggest an association between vitamin D deficiency and an increased risk of developing insulin resistance or type 2 diabetes.	Vitamin D	97-106	insulin	Homo sapiens	154-161
31689953-9	2019	Patients with insulin resistance who are vitamin D deficient should be treated with an appropriate amount of vitamin D to achieve circulating levels of 25(OH)D of 40-60 ng/mL.	Vitamin D	41-50	insulin	Homo sapiens	14-21
31689953-9	2019	Patients with insulin resistance who are vitamin D deficient should be treated with an appropriate amount of vitamin D to achieve circulating levels of 25(OH)D of 40-60 ng/mL.	Vitamin D	109-118	insulin	Homo sapiens	14-21
31559433-3	2019	OBJECTIVE: The purpose of this double-blind randomized placebo-controlled trial was to investigate the effect of vitamin D3 supplementation on insulin resistance (IR) and beta-cell function in people with prediabetes and suboptimal vitamin D status (&lt;50 nmol/L).	Vitamin D	113-122	insulin	Homo sapiens	143-150
30885444-0	2019	Vitamin D deficiency in a psychiatric population and correlation between vitamin D and CRP.	Vitamin D	73-82	C-reactive protein	Homo sapiens	87-90
31634867-1	2019	BACKGROUND: Vitamin D deficiency is common in obese adolescents and a risk factor for insulin resistance.	Vitamin D	12-21	insulin	Homo sapiens	86-93
31520697-0	2019	Parathyroid hormone response to different vitamin D levels in population-based old and very-old Polish cohorts.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	0-19
30829137-1	2019	The present randomized, double-blind, placebo controlled study aimed to evaluate the effect of vitamin D supplementation on matrix metalloproteinases-2, -9 (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in subjects with metabolic syndrome.	Vitamin D	95-104	TIMP metallopeptidase inhibitor 1	Homo sapiens	178-217
30829137-1	2019	The present randomized, double-blind, placebo controlled study aimed to evaluate the effect of vitamin D supplementation on matrix metalloproteinases-2, -9 (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in subjects with metabolic syndrome.	Vitamin D	95-104	TIMP metallopeptidase inhibitor 1	Homo sapiens	219-225
30180151-3	2019	AIM: The aim of this study is to determine the association between parathyroid hormone (PTH) and vitamin D deficiency with GERD symptoms, erosive esophagitis, and Barrett"s esophagus.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	67-86
31162534-7	2019	There is also heightened resistance to insulin due to metabolic acidosis, uremic toxins, inflammatory state, and vitamin D deficiency.	Vitamin D	113-122	insulin	Homo sapiens	39-46
31310310-8	2019	RESULTS: PTH therapy was associated with a progressive reduction in supplemental calcium (57%; p &lt; 0.01) and active vitamin D (76%; p &lt; 0.001) requirements over 8 years.	Vitamin D	119-128	parathyroid hormone	Homo sapiens	9-12
31356558-8	2019	Increase in vitamin D levels correlated with reduction in UCDAI score (P<=0.001; rho=-0.713), C-reactive protein (P<=0.001; rho=-0.603), and calprotectin (P=0.004; rho=-0.368).	Vitamin D	12-21	C-reactive protein	Homo sapiens	94-112
31273631-0	2019	Parathyroid hormone reference ranges in healthy individuals classified by vitamin D status.	Vitamin D	74-83	parathyroid hormone	Homo sapiens	0-19
31273631-5	2019	RESULTS: In vitamin D sufficiency, median PTH was 31.9 pg/mL [range (2.5th-97.5th percentile) 17.9-58.6] compared with 35.5 pg/mL (17.0-60.4) for insufficiency, and 39.8 pg/mL (19.5-86.4) for deficiency.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	42-45
31273631-8	2019	CONCLUSIONS: Upper reference limits (URL) for PTH in vitamin D sufficiency/insufficiency were similar and lower than current values.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	46-49
31273631-9	2019	Clinically important PTH elevations were observed in vitamin D deficiency, where revised reference ranges with a higher URL may be appropriate.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	21-24
31273631-10	2019	These data may help to distinguish vitamin D-related PTH elevations from other causes [e.g., primary (normocalcemic) or secondary hyperparathyroidism].	Vitamin D	35-44	parathyroid hormone	Homo sapiens	53-56
30520760-13	2019	These findings provide basis for further studies into the regulation of TSP-1 by vitamin D.	Vitamin D	81-90	thrombospondin 1	Homo sapiens	72-77
31377485-5	2019	Objectives of this study are to evaluate the modulatory effect of vitamin D on CTSL activity in post-PTCA coronary arteries of atherosclerotic swine.	Vitamin D	66-75	cathepsin L1	Sus scrofa	79-83
31377485-14	2019	Notably, the expression of CTSL was significantly increased in postangioplasty LCx of vitamin D-deficient swine compared with the vitamin D-sufficient or vitamin D-supplemented animal groups.	Vitamin D	86-95	cathepsin L1	Sus scrofa	27-31
31377485-14	2019	Notably, the expression of CTSL was significantly increased in postangioplasty LCx of vitamin D-deficient swine compared with the vitamin D-sufficient or vitamin D-supplemented animal groups.	Vitamin D	130-139	cathepsin L1	Sus scrofa	27-31
31377485-14	2019	Notably, the expression of CTSL was significantly increased in postangioplasty LCx of vitamin D-deficient swine compared with the vitamin D-sufficient or vitamin D-supplemented animal groups.	Vitamin D	130-139	cathepsin L1	Sus scrofa	27-31
31377485-16	2019	However, in the presence of sufficient or supplemented levels of vitamin D in the blood, CTSL expression was significantly reduced.	Vitamin D	65-74	cathepsin L1	Sus scrofa	89-93
31375874-2	2019	Vitamin D and calcium supplements increased IGF-1 but did not affect bone mineralization or turnover.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	44-49
31375874-11	2019	CONCLUSIONS: Our study showed that in healthy adolescents with low vitamin D status and calcium intake, mild vitamin D and mild to modest calcium supplements increased IGF-1 but did not affect bone mineralization or turnover.	Vitamin D	109-118	insulin like growth factor 1	Homo sapiens	168-173
31650259-1	2019	Our research shows that the newborns of vitamin D-deficient mothers have higher serum alkaline phosphatase (ALP) activity compared with those of vitamin D-non-deficient mothers, which is likely related to increased bone turnover rather than just being a marker for bone formation.	Vitamin D	40-49	alkaline phosphatase, placental	Homo sapiens	108-111
31650259-10	2019	ALP activity was significantly higher in newborns of vitamin D-deficient compared with vitamin D-non-deficient mothers (median = 176 (IQR = 139-221) and 156 (IQR = 132-182), respectively, p = 0.04).	Vitamin D	53-62	alkaline phosphatase, placental	Homo sapiens	0-3
31650259-10	2019	ALP activity was significantly higher in newborns of vitamin D-deficient compared with vitamin D-non-deficient mothers (median = 176 (IQR = 139-221) and 156 (IQR = 132-182), respectively, p = 0.04).	Vitamin D	87-96	alkaline phosphatase, placental	Homo sapiens	0-3
31650259-13	2019	CONCLUSIONS: Our findings indicate that newborns of vitamin D-deficient mothers have higher serum ALP activity than those of non-deficient mothers, which might be related to increased bone turnover rather than just being a marker for bone formation.	Vitamin D	52-61	alkaline phosphatase, placental	Homo sapiens	98-101
31673295-9	2019	Moreover, AGES and TNF-alpha serum levels significantly reduced in vitamin D group, but they were remained unchanged in the placebo group.	Vitamin D	67-76	tumor necrosis factor	Homo sapiens	19-28
31777705-6	2019	Results: During the intervention, PTH (mean difference, -33.36; 95% CI: -49.15 to -17.57;P&lt;0.001) and LDL-C (mean difference, -15.91; 95% CI: -21.76 to -10.07; P&lt;0.001) decreased and 25(OH) D (mean difference, 36.44; 95% CI: 29.05 to 43.83; P&lt;0.001) increased significantly in the vitamin D group.	Vitamin D	290-299	parathyroid hormone	Homo sapiens	34-37
31640823-1	2020	Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory.	Vitamin D	18-27	protein disulfide isomerase family A member 3	Homo sapiens	128-133
31640710-1	2019	BACKGROUND: Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease.	Vitamin D	36-45	D-box binding PAR bZIP transcription factor	Homo sapiens	104-107
31640710-1	2019	BACKGROUND: Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease.	Vitamin D	36-45	D-box binding PAR bZIP transcription factor	Homo sapiens	122-125
31651513-12	2019	VDR mRNA levels positively correlated with the pre-pregnancy body mass index (BMI), pre-delivery BMI, fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), and PPARgamma mRNA while it negatively correlated with the VD and the adiponectin levels (r = 0.395, 0.336, 0.240, 0.190, 0.235, -0.350, -0.294, respectively, P &lt; 0.05).	Vitamin D	0-2	adiponectin, C1Q and collagen domain containing	Homo sapiens	263-274
31651513-14	2019	PPARgamma mRNA levels positively correlated with pre-pregnancy BMI, pre-delivery BMI, FBG, HOMA-IR, serum total cholesterol, triglyceride, free fatty acid, and VDR mRNA, while it negatively correlated with the VD and adiponectin levels (r = 0.276, 0.199, 0.210, 0.230, 0.182, 0.214, 0.270, 0.235, -0.232, -0.199, respectively, P &lt; 0.05).	Vitamin D	160-162	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
30632078-6	2019	The most common PIM was use of proton pump inhibitors while the most common PPO was omission of vitamin D supplements in housebound patients or patients experiencing falls.	Vitamin D	96-105	protoporphyrinogen oxidase	Homo sapiens	76-79
31689953-2	2019	Various studies have indicated that a lack of vitamin D must be regarded as a pathogenic factor for type 2 diabetes and the metabolic syndrome, since a vitamin D deficiency (25(OH)D &lt; 20 ng/mL) increases insulin resistance and reduces insulin secretion from beta cells in the pancreas.	Vitamin D	46-55	insulin	Homo sapiens	207-214
31689953-2	2019	Various studies have indicated that a lack of vitamin D must be regarded as a pathogenic factor for type 2 diabetes and the metabolic syndrome, since a vitamin D deficiency (25(OH)D &lt; 20 ng/mL) increases insulin resistance and reduces insulin secretion from beta cells in the pancreas.	Vitamin D	152-161	insulin	Homo sapiens	207-214
31689953-2	2019	Various studies have indicated that a lack of vitamin D must be regarded as a pathogenic factor for type 2 diabetes and the metabolic syndrome, since a vitamin D deficiency (25(OH)D &lt; 20 ng/mL) increases insulin resistance and reduces insulin secretion from beta cells in the pancreas.	Vitamin D	152-161	insulin	Homo sapiens	238-245
30701437-8	2019	Meanwhile, patients with absence of PTH response to low vitamin D levels, were not repeated fallers and suffered mostly from subcapital fractures.	Vitamin D	56-65	parathyroid hormone	Homo sapiens	36-39
31681485-0	2019	Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-alpha.	Vitamin D	0-9	cadherin 1	Homo sapiens	20-30
31681485-0	2019	Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-alpha.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	133-142
31681485-2	2019	In the present study, the effect of vitamin D on strengthening E-cadherin junctions (ECJs) was explored in human gingival keratinocytes (HGKs).	Vitamin D	36-45	cadherin 1	Homo sapiens	63-73
31681485-13	2019	Vitamin D reduced the production of MMP-9 and attenuated the breakdown of ECJs in the HGKs treated with TNF-alpha.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	104-113
31681485-14	2019	In addition, vitamin D downregulated TNF-alpha-induced nuclear factor kappa B (NF-kappaB) signaling in the HGKs.	Vitamin D	13-22	tumor necrosis factor	Homo sapiens	37-46
31681485-14	2019	In addition, vitamin D downregulated TNF-alpha-induced nuclear factor kappa B (NF-kappaB) signaling in the HGKs.	Vitamin D	13-22	nuclear factor kappa B subunit 1	Homo sapiens	55-77
31681485-14	2019	In addition, vitamin D downregulated TNF-alpha-induced nuclear factor kappa B (NF-kappaB) signaling in the HGKs.	Vitamin D	13-22	nuclear factor kappa B subunit 1	Homo sapiens	79-88
31681485-16	2019	Conclusions: These results suggest that vitamin D may avert TNF-alpha-induced downregulation of the development of ECJs in HGKs by decreasing the production of MMP-9, which was upregulated by TNF-alpha.	Vitamin D	40-49	tumor necrosis factor	Homo sapiens	60-69
31681485-16	2019	Conclusions: These results suggest that vitamin D may avert TNF-alpha-induced downregulation of the development of ECJs in HGKs by decreasing the production of MMP-9, which was upregulated by TNF-alpha.	Vitamin D	40-49	tumor necrosis factor	Homo sapiens	192-201
31681485-17	2019	Vitamin D may reinforce ECJs by downregulating NF-kappaB signaling, which is upregulated by TNF-alpha.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	47-56
31681485-17	2019	Vitamin D may reinforce ECJs by downregulating NF-kappaB signaling, which is upregulated by TNF-alpha.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	92-101
31526009-1	2019	INTRODUCTION: much evidence confirms that vitamin D may be associated with an improvement in CD4 cell counts in HIV-infected individuals, where antiretroviral therapy (ART) is used and associated with decreased 25(OH)D levels.	Vitamin D	42-51	CD4 molecule	Homo sapiens	93-96
32153959-1	2019	Background: Vitamin D deficiency is associated with indicators of pre-diabetes including, insulin resistance, beta-cell dysfunction and elevated plasma glucose with controversial findings from current trials.	Vitamin D	12-21	insulin	Homo sapiens	90-97
31582399-4	2019	RESULTS: Vitamin D enhanced in vitro IFN responses, as measured by induction of p-Y-STAT1 and MxA in MNCs, T cells, and monocytes.	Vitamin D	9-18	interferon alpha 1	Homo sapiens	37-40
31582399-5	2019	Vitamin D augmentation of IFN responses was seen in untreated and in IFN-beta-1b-treated MS.	Vitamin D	0-9	interferon alpha 1	Homo sapiens	26-29
31582399-5	2019	Vitamin D augmentation of IFN responses was seen in untreated and in IFN-beta-1b-treated MS.	Vitamin D	0-9	interferon alpha 1	Homo sapiens	69-72
31582399-7	2019	Exacerbations and progression in untreated patients reduced the vitamin D enhancement of IFN responses.	Vitamin D	64-73	interferon alpha 1	Homo sapiens	89-92
31582399-8	2019	Vitamin D had less effect on IFN response in clinically stable glatiramer-treated than in IFN-beta-treated patients.	Vitamin D	0-9	interferon alpha 1	Homo sapiens	29-32
30701437-9	2019	DISCUSSION AND CONCLUSION: Elevated PTH levels predispose both to falls and trochanteric fractures, while vitamin D-deficient patients with normal PTH levels are mostly related to subcapital fractures.	Vitamin D	106-115	parathyroid hormone	Homo sapiens	147-150
31332821-1	2019	The aim of this systematic review and meta-analysis was to evaluate the effect of vitamin D supplementation on total testosterone (TT) and sex hormone-binding globulin (SHBG) in men.	Vitamin D	82-91	sex hormone binding globulin	Homo sapiens	139-167
31332821-1	2019	The aim of this systematic review and meta-analysis was to evaluate the effect of vitamin D supplementation on total testosterone (TT) and sex hormone-binding globulin (SHBG) in men.	Vitamin D	82-91	sex hormone binding globulin	Homo sapiens	169-173
31274211-8	2019	Compared to placebo, vitamin D had significant decreasing effects on serum TNF-alpha, IFN-gamma, and IL12p70 levels, but it had no significant effect on serum levels of IL4 and IL10.	Vitamin D	21-30	tumor necrosis factor	Homo sapiens	75-84
31482615-4	2019	Increasing serum vitamin D levels is considered that induce expression of TGF-beta1.	Vitamin D	17-26	transforming growth factor beta 1	Homo sapiens	74-83
31274211-8	2019	Compared to placebo, vitamin D had significant decreasing effects on serum TNF-alpha, IFN-gamma, and IL12p70 levels, but it had no significant effect on serum levels of IL4 and IL10.	Vitamin D	21-30	interferon gamma	Homo sapiens	86-95
31250032-5	2019	Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects.	Vitamin D	38-47	renin binding protein	Homo sapiens	58-61
30459099-7	2019	Vitamin D and probiotic co-supplementation significantly decreased triglycerides (P = 0.02), VLDL-cholesterol (P = 0.02) and hs-CRP (P = 0.01), and significantly increased TAC (P = 0.006) and total glutathione levels (P = 0.04) compared with only probiotic group.	Vitamin D	0-9	C-reactive protein	Homo sapiens	128-131
31250032-0	2019	Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases.	Vitamin D	25-34	renin binding protein	Homo sapiens	38-41
31400903-13	2019	Vitamin D-fortified yogurt may be beneficial in improving serum 25OHD, lipid profile, glucose metabolism, and anthropometric parameters and decreasing parathyroid hormone level in pregnant women and adult and elderly subjects with or without diabetes, prediabetes, or metabolic syndrome.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	151-170
31485996-4	2019	Particularly, we focus on the adequate control of serum phosphorus by restricting intake and the use of phosphate binders, correction of hypocalcemia while minimizing calcium burden, and reduction in PTH levels through the use of vitamin D sterols and calcimimetics.	Vitamin D	230-239	parathyroid hormone	Homo sapiens	200-203
31408845-0	2019	Vitamin D affects insulin sensitivity and beta-cell function in obese non-diabetic youths.	Vitamin D	0-9	insulin	Homo sapiens	18-25
31614338-0	2019	Thrombin generation and fibrin clot structure after vitamin D supplementation.	Vitamin D	52-61	coagulation factor II, thrombin	Homo sapiens	0-8
31326626-0	2019	Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism.	Vitamin D	51-60	epidermal growth factor receptor	Homo sapiens	86-90
31255688-14	2019	Higher levels of Vitamin D along with VDR and iNOS expression in household contacts as compared to active TB patients suggest vitamin D might have a protective role against TB plausibly decreasing disease susceptibility.	Vitamin D	126-135	nitric oxide synthase 2	Homo sapiens	46-50
31326626-0	2019	Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism.	Vitamin D	51-60	tumor protein p53	Homo sapiens	98-101
31326626-5	2019	The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs).	Vitamin D	171-180	epidermal growth factor receptor	Homo sapiens	61-65
31326626-5	2019	The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs).	Vitamin D	171-180	tumor protein p53	Homo sapiens	73-76
31430707-1	2019	BACKGROUND: Although modulation of the vitamin D receptor (VDR) and endothelin-A receptor (ETAR) has previously been reported to offer renoprotection against cisplatin-induced nephrotoxicity, the possible interaction between the ET-1 and vitamin D pathways remains obscure.	Vitamin D	39-48	endothelin 1	Rattus norvegicus	229-233
31463983-8	2019	Moreover, vitamin D deficiency significantly attenuated alcohol-induced sterol-regulated element-binding protein (SREBP)-1c activation, which regulates genes for hepatic fatty acid (FA) and TAG synthesis, and the expression of its target genes fatty acid synthase (Fasn) and acetyl-coenzyme- A carboxylase (Acc).	Vitamin D	10-19	fatty acid synthase	Mus musculus	244-263
31463983-8	2019	Moreover, vitamin D deficiency significantly attenuated alcohol-induced sterol-regulated element-binding protein (SREBP)-1c activation, which regulates genes for hepatic fatty acid (FA) and TAG synthesis, and the expression of its target genes fatty acid synthase (Fasn) and acetyl-coenzyme- A carboxylase (Acc).	Vitamin D	10-19	fatty acid synthase	Mus musculus	265-269
31463983-9	2019	In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation.	Vitamin D	13-22	peroxisome proliferator activated receptor alpha	Mus musculus	95-149
31463983-9	2019	In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation.	Vitamin D	13-22	cytochrome P450, family 4, subfamily a, polypeptide 14	Mus musculus	332-339
31295461-0	2019	The correlation between low vitamin D status and renal interleukin-6/STAT3 hyper-activation in patients with clear cell renal cell carcinoma.	Vitamin D	28-37	interleukin 6	Homo sapiens	55-68
31295461-0	2019	The correlation between low vitamin D status and renal interleukin-6/STAT3 hyper-activation in patients with clear cell renal cell carcinoma.	Vitamin D	28-37	signal transducer and activator of transcription 3	Homo sapiens	69-74
31295461-15	2019	Our results provide evidence that low vitamin D status is correlated with hyper-activation of cancerous IL-6/STAT3 and proliferation in ccRCC patients.	Vitamin D	38-47	signal transducer and activator of transcription 3	Homo sapiens	109-114
31295461-2	2019	This study aimed to analyze the link between low vitamin D status and interleukin (IL)-6/STAT3 hyper-activation in clear cell RCC (ccRCC) patients.	Vitamin D	49-58	interleukin 6	Homo sapiens	70-88
31295461-2	2019	This study aimed to analyze the link between low vitamin D status and interleukin (IL)-6/STAT3 hyper-activation in clear cell RCC (ccRCC) patients.	Vitamin D	49-58	signal transducer and activator of transcription 3	Homo sapiens	89-94
31295461-4	2019	The association between low vitamin D status and IL-6/STAT3 hyper-activation was analyzed.	Vitamin D	28-37	interleukin 6	Homo sapiens	49-53
31295461-4	2019	The association between low vitamin D status and IL-6/STAT3 hyper-activation was analyzed.	Vitamin D	28-37	signal transducer and activator of transcription 3	Homo sapiens	54-59
31295461-15	2019	Our results provide evidence that low vitamin D status is correlated with hyper-activation of cancerous IL-6/STAT3 and proliferation in ccRCC patients.	Vitamin D	38-47	interleukin 6	Homo sapiens	104-108
31278171-1	2019	INTRODUCTION: Vitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1alpha-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	190-197
31650823-8	2019	67% of patients with insufficient vit D (25-50nmol/L) were prescribed a stat high dose vitamin D (120,000 IU) to help avoid adherence issues.	Vitamin D	87-96	vitrin	Homo sapiens	34-37
31278171-1	2019	INTRODUCTION: Vitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1alpha-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze.	Vitamin D	97-106	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	190-197
31278171-1	2019	INTRODUCTION: Vitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1alpha-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze.	Vitamin D	160-169	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	190-197
31467173-2	2019	CYP27B1 and group-specific component (GC), the main enzyme responsible for the degradation and transport of active vitamin D, play important role in many cancer-related cellular processes.	Vitamin D	115-124	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
31394158-11	2019	Furthermore, vitamin D suppressed BDL-induced elevated hepatic TGF-beta1 mRNA and protein levels.	Vitamin D	13-22	transforming growth factor, beta 1	Rattus norvegicus	63-72
31394158-13	2019	Treatment with vitamin D reduced Smo mRNA levels and suppressed hepatic Gli1 mRNA and protein levels.	Vitamin D	15-24	smoothened, frizzled class receptor	Rattus norvegicus	33-36
31394158-14	2019	Molecular docking of vitamin D to Smo revealed that vitamin D binds similarly to its endogenous cholesterol ligand and blocks its activation.	Vitamin D	21-30	smoothened, frizzled class receptor	Rattus norvegicus	34-37
31394158-14	2019	Molecular docking of vitamin D to Smo revealed that vitamin D binds similarly to its endogenous cholesterol ligand and blocks its activation.	Vitamin D	52-61	smoothened, frizzled class receptor	Rattus norvegicus	34-37
31506836-5	2019	Low vitamin D status appears to be associated with type 2 diabetes and most other insulin resistance disorders reported to date.	Vitamin D	4-13	insulin	Homo sapiens	82-89
31550271-0	2019	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.	Vitamin D	0-9	CD4 molecule	Homo sapiens	135-138
31509973-7	2019	Vitamin D supplementation prevented the increase of Akt phosphorylation in the ovaries.	Vitamin D	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
31509973-11	2019	Preventing Akt phosphorylation may contribute to the beneficial effect of vitamin D treatment on ovarian function in hyperandrogenism.	Vitamin D	74-83	AKT serine/threonine kinase 1	Rattus norvegicus	11-14
31583252-5	2019	Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients.	Vitamin D	172-181	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	118-125
31344685-0	2019	Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: a randomized, placebo-controlled trial.	Vitamin D	19-28	insulin	Homo sapiens	48-55
31491877-0	2019	Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents.	Vitamin D	10-19	insulin	Homo sapiens	55-62
31491877-2	2019	The aim of this study is to investigate the relationship between serum vitamin D levels and the factors linked to insulin resistance.	Vitamin D	71-80	insulin	Homo sapiens	114-121
31491877-8	2019	An inverse relationship between insulin resistance and serum vitamin D is observed (OR (odds ratios) = 2.9; 95% CI (95% confidence intervals): 1.1, 7.2; p-trend 0.03).	Vitamin D	61-70	insulin	Homo sapiens	32-39
31491877-9	2019	Low serum vitamin D levels are associated with insulin resistance in the pediatric population.	Vitamin D	10-19	insulin	Homo sapiens	47-54
31491877-10	2019	The present study provides additional evidence for the role of vitamin D in insulin resistance.	Vitamin D	63-72	insulin	Homo sapiens	76-83
31491877-11	2019	Our findings suggest the supplementation of vitamin D may be helpful in preventing insulin resistance and subsequent diabetes.	Vitamin D	44-53	insulin	Homo sapiens	83-90
31261027-10	2019	However, Overexpression of VDR and vitamin D treatment could induce the cell survival and alleviate the FoxO1-induced cell apoptosis, furthermore, vitamin D treatment or silencing of FoxO1 gene could reverse the ROS-induced cell apoptosis.	Vitamin D	35-44	forkhead box O1	Homo sapiens	104-109
31261027-10	2019	However, Overexpression of VDR and vitamin D treatment could induce the cell survival and alleviate the FoxO1-induced cell apoptosis, furthermore, vitamin D treatment or silencing of FoxO1 gene could reverse the ROS-induced cell apoptosis.	Vitamin D	147-156	forkhead box O1	Homo sapiens	104-109
31261027-11	2019	Therefore, our results support that vitamin D may protect FoxO1-induced pancreatic beta cell apoptosis, which suggests that vitamin D may have beneficial effects in preventing and treating GDM.	Vitamin D	36-45	forkhead box O1	Homo sapiens	58-63
31261027-11	2019	Therefore, our results support that vitamin D may protect FoxO1-induced pancreatic beta cell apoptosis, which suggests that vitamin D may have beneficial effects in preventing and treating GDM.	Vitamin D	124-133	forkhead box O1	Homo sapiens	58-63
30696977-0	2019	Effects of vitamin D supplements on frequency of CD4+ T-cell subsets in women with Hashimoto"s thyroiditis: a double-blind placebo-controlled study.	Vitamin D	11-20	CD4 molecule	Homo sapiens	49-52
30316967-5	2019	Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D.	Vitamin D	163-172	amidohydrolase domain containing 1	Homo sapiens	135-141
31325540-1	2019	Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes?	Vitamin D	15-24	insulin	Homo sapiens	48-55
31344685-8	2019	CONCLUSIONS: In individuals at high risk of diabetes or with newly diagnosed type 2 diabetes, vitamin D supplementation for 6 months significantly increased peripheral insulin sensitivity and beta-cell function, suggesting that it may slow metabolic deterioration in this population.	Vitamin D	94-103	insulin	Homo sapiens	168-175
31803590-1	2019	Vitamin D plays an important role in glucose tolerance by stimulating insulin secretion and evidences suggest a contradictory result on the association between vitamin D status and risk of developing gestational diabetes mellitus (GDM).	Vitamin D	0-9	insulin	Homo sapiens	70-77
30887870-4	2019	Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients.	Vitamin D	125-134	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	107-114
30887870-8	2019	In addition, we identified gene-gene interactions between variants in genes KL, CYP27B1 and VDR related to vitamin D-metabolism and low-BMD in TS-patients.	Vitamin D	107-116	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	80-87
31803595-1	2019	Objective: Vitamin D deficiency has been found to be associated with insulin resistance.	Vitamin D	11-20	insulin	Homo sapiens	69-76
31385179-13	2019	CONCLUSION: CRP levels and NLR values were significantly higher in the vitamin D deficiency group.	Vitamin D	71-80	C-reactive protein	Homo sapiens	12-15
31385179-14	2019	A significant inverse correlation was found between serum vitamin D levels and CRP levels, and NLR and PLR values.	Vitamin D	58-67	C-reactive protein	Homo sapiens	79-82
31338797-0	2019	The effects of vitamin D treatment on glycemic control, serum lipid profiles, and C-reactive protein in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.	Vitamin D	15-24	C-reactive protein	Homo sapiens	82-100
31675537-0	2019	Low dietary magnesium intake alters vitamin D-parathyroid hormone relationship in adults who are overweight or obese.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	46-65
31338797-10	2019	CONCLUSIONS: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation or treatment on improving fasting glucose, HOMA-IR, triglycerides and cholesterol levels among patients with CKD, though it did not influence insulin, HbA1c, LDL and HDL cholesterol, and CRP levels.	Vitamin D	71-80	insulin	Homo sapiens	239-246
31338797-10	2019	CONCLUSIONS: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation or treatment on improving fasting glucose, HOMA-IR, triglycerides and cholesterol levels among patients with CKD, though it did not influence insulin, HbA1c, LDL and HDL cholesterol, and CRP levels.	Vitamin D	71-80	C-reactive protein	Homo sapiens	284-287
31201030-0	2019	Free Vitamin D: Relationship to Insulin Sensitivity and Vascular Health in Youth.	Vitamin D	5-14	insulin	Homo sapiens	32-39
31201030-1	2019	OBJECTIVE: To evaluate the relationship of free 25 hydroxy vitamin D [free 25(OH)D] or bioavailable vitamin D (BioD) concentrations to insulin sensitivity and cardiovascular disease risk markers in normal weight and overweight youth.	Vitamin D	59-68	insulin	Homo sapiens	135-142
31065919-10	2019	Type of surgery, vitamin D serum concentrations, and 2-year BMI were all independently associated with PTH levels.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	103-106
31675537-1	2019	Vitamin D metabolism is dependent on magnesium (Mg) as a cofactor; therefore, poor Mg status may alter the relationship between vitamin D metabolite serum 25-hydroxyvitamin D (s25OHD) and serum parathyroid hormone (sPTH).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	194-213
31675537-1	2019	Vitamin D metabolism is dependent on magnesium (Mg) as a cofactor; therefore, poor Mg status may alter the relationship between vitamin D metabolite serum 25-hydroxyvitamin D (s25OHD) and serum parathyroid hormone (sPTH).	Vitamin D	128-137	parathyroid hormone	Homo sapiens	194-213
31095994-9	2019	Combining data from five studies, we found a significant reduction in C-reactive protein (CRP) concentrations after vitamin D supplementation (WMD: -1.74; 95% CI: -2.82, -0.66).	Vitamin D	116-125	C-reactive protein	Homo sapiens	70-88
31095994-9	2019	Combining data from five studies, we found a significant reduction in C-reactive protein (CRP) concentrations after vitamin D supplementation (WMD: -1.74; 95% CI: -2.82, -0.66).	Vitamin D	116-125	C-reactive protein	Homo sapiens	90-93
31095994-10	2019	CONCLUSIONS: Overall, the current meta-analysis demonstrated that taking vitamin D supplements among patients with psychiatric disorders had beneficial effects on BDI, PSQI, GSH, TAC and CRP levels, but did not affect other biomarkers of inflammation and oxidative stress.	Vitamin D	73-82	C-reactive protein	Homo sapiens	187-190
31406210-4	2019	Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma.	Vitamin D	98-107	interferon gamma	Homo sapiens	194-203
31091067-0	2019	The Effect of Vitamin D Supplementation on Insulin Resistance among Women with Polycystic Ovary Syndrome.	Vitamin D	14-23	insulin	Homo sapiens	43-50
31091067-1	2019	OBJECTIVE: To explore the effect of vitamin D supplementation on insulin resistance in a group of Iranian patients with polycystic ovary syndrome and vitamin D deficiency.	Vitamin D	36-45	insulin	Homo sapiens	65-72
31091067-1	2019	OBJECTIVE: To explore the effect of vitamin D supplementation on insulin resistance in a group of Iranian patients with polycystic ovary syndrome and vitamin D deficiency.	Vitamin D	150-159	insulin	Homo sapiens	65-72
31091067-9	2019	There was a significant decrease in the mean fasting serum insulin level from 8.52+-5.48 mcU/mL before treatment with vitamin D to 7.07+-5.03 (p=0.019) microU/mL after the treatment.	Vitamin D	118-127	insulin	Homo sapiens	59-66
31091067-9	2019	There was a significant decrease in the mean fasting serum insulin level from 8.52+-5.48 mcU/mL before treatment with vitamin D to 7.07+-5.03 (p=0.019) microU/mL after the treatment.	Vitamin D	118-127	mitochondrial calcium uniporter	Homo sapiens	89-92
31091067-11	2019	CONCLUSIONS: A single injection of vitamin D significantly decreased serum insulin levels and insulin resistance among patients with polycystic ovary syndrome.	Vitamin D	35-44	insulin	Homo sapiens	75-82
31091067-11	2019	CONCLUSIONS: A single injection of vitamin D significantly decreased serum insulin levels and insulin resistance among patients with polycystic ovary syndrome.	Vitamin D	35-44	insulin	Homo sapiens	94-101
31416155-10	2019	In middle-aged healthy men, vitamin D treatment had a negative effect on insulin sensitivity.	Vitamin D	28-37	insulin	Homo sapiens	73-80
31406139-0	2019	Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Homo sapiens	36-40
31406139-0	2019	Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit.	Vitamin D	0-9	microRNA 375	Homo sapiens	118-125
31328813-1	2019	Current understanding of vitamin D tends to be focussed on the measurement of the major circulating form 25-hydroxyvitamin D3 (25OHD3) and its conversion to the active hormonal form, 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2 D3) via the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1).	Vitamin D	25-34	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	288-295
31350741-0	2019	[Vitamin D Supplementation in Older Adults: is the Hype Definitely Over?]	Vitamin D	1-10	FIC domain protein adenylyltransferase	Homo sapiens	51-55
29946756-1	2019	PURPOSE: Vitamin D status may be associated with insulin resistance and other key features of polycystic ovary syndrome (PCOS), but data from preliminary randomized controlled trials (RCTs) are conflicting.	Vitamin D	9-18	insulin	Homo sapiens	49-56
31084577-5	2019	In addition, immunocytochemistry, quantitative real-time PCR, and immunoblotting analysis showed that vitamin D increased endothelial interconnections through vascular endothelial cadherin (VE-cadherin) junctions and by impacting cell dynamics through cofilin and VE-cadherin phosphorylation.	Vitamin D	102-111	cadherin 5	Homo sapiens	159-188
31084577-5	2019	In addition, immunocytochemistry, quantitative real-time PCR, and immunoblotting analysis showed that vitamin D increased endothelial interconnections through vascular endothelial cadherin (VE-cadherin) junctions and by impacting cell dynamics through cofilin and VE-cadherin phosphorylation.	Vitamin D	102-111	cadherin 5	Homo sapiens	190-201
31084577-5	2019	In addition, immunocytochemistry, quantitative real-time PCR, and immunoblotting analysis showed that vitamin D increased endothelial interconnections through vascular endothelial cadherin (VE-cadherin) junctions and by impacting cell dynamics through cofilin and VE-cadherin phosphorylation.	Vitamin D	102-111	cadherin 5	Homo sapiens	264-275
30883882-0	2019	Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein.	Vitamin D	122-131	estrogen receptor 1	Homo sapiens	0-17
30600434-2	2019	Several hormones such as Testosterone (T) and Vitamin D (VD) have been shown to affect energy-dependent cell trafficking by determining Insulin (I)-like effects.	Vitamin D	46-55	insulin	Homo sapiens	136-143
31229911-3	2019	Our previous study showed that vitamin D (VD3) decreases breast cancer aggressiveness by inhibiting mammalian target of rapamycin (mTOR).	Vitamin D	31-40	mechanistic target of rapamycin kinase	Homo sapiens	100-129
31229911-3	2019	Our previous study showed that vitamin D (VD3) decreases breast cancer aggressiveness by inhibiting mammalian target of rapamycin (mTOR).	Vitamin D	31-40	mechanistic target of rapamycin kinase	Homo sapiens	131-135
30802957-10	2019	Cultured GEC expressed two 25-hydroxylases (CYP27A1 and CYP2R1), as well as 1-alpha hydroxylase, enabling conversion of vitamin D to both 25(OH)D3 and 1,25(OH)2 D3 .	Vitamin D	120-129	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	44-51
31347309-10	2019	Patients with high plasma fibrinogen concentrations and low 25-OH vitamin D levels had lower lung function, higher severity index, and higher annual rate of severe exacerbations 12 months before (0.23/year) and after (0.41/year) the measurement of 25-OH vitamin D levels than did the other patients.	Vitamin D	254-263	fibrinogen beta chain	Homo sapiens	26-36
31347309-12	2019	The measurement of plasma fibrinogen concentrations could help identify a severe phenotypic group among patients with vitamin D deficiency.	Vitamin D	118-127	fibrinogen beta chain	Homo sapiens	26-36
31592277-0	2019	Relationship between Vitamin D Level and Serum TNF-alpha Concentration on the Severity of Chronic Obstructive Pulmonary Disease.	Vitamin D	21-30	tumor necrosis factor	Homo sapiens	47-56
31592277-2	2019	Vitamin D deficiency is sometimes observed in COPD patients and as significant roles in increasing inflammation of airway obstruction and systemic obstruction, increasing pro-inflammatory cytokine including TNF-alpha, reduction of bacterial clearance and increase exacerbation risk due to infection.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	207-216
31592277-5	2019	Several studies that investigate the relationship between vitamin D level and serum TNF-alpha concentration in COPD patients are relatively uncommon, including in Indonesia.	Vitamin D	58-67	tumor necrosis factor	Homo sapiens	84-93
31592277-6	2019	AIM: This study aimed to assess the relationship between vitamin D level and TNF-alpha concentration in patients on the severity of the chronic obstructive pulmonary disease.	Vitamin D	57-66	tumor necrosis factor	Homo sapiens	77-86
31592277-19	2019	Given the relationship between vitamin D level and serum TNF-alpha concentration on the airway obstruction, there were significant positive correlations between the increase of vitamin D levels and the increase of serum TNF-alpha concentrations on airway obstruction.	Vitamin D	31-40	tumor necrosis factor	Homo sapiens	57-66
31592277-19	2019	Given the relationship between vitamin D level and serum TNF-alpha concentration on the airway obstruction, there were significant positive correlations between the increase of vitamin D levels and the increase of serum TNF-alpha concentrations on airway obstruction.	Vitamin D	177-186	tumor necrosis factor	Homo sapiens	57-66
31592277-19	2019	Given the relationship between vitamin D level and serum TNF-alpha concentration on the airway obstruction, there were significant positive correlations between the increase of vitamin D levels and the increase of serum TNF-alpha concentrations on airway obstruction.	Vitamin D	177-186	tumor necrosis factor	Homo sapiens	220-229
31592277-20	2019	Given the relationship between vitamin D level and serum TNF-alpha concentration on the severity of COPD, there were significant positive correlations between the increase of vitamin D levels (tertiles 1, 2 and 3) and the increase of serum TNF-alpha concentrations on the severity of COPD at p-value &lt; 0.05.	Vitamin D	175-184	tumor necrosis factor	Homo sapiens	240-249
31592277-21	2019	Overall, there were non-linear relationships between vitamin D level and serum TNF-alpha concentration on the severity of COPD.	Vitamin D	53-62	tumor necrosis factor	Homo sapiens	79-88
31340522-8	2019	At 12 months, IgE sensitized children had a lower intake of vitamin D (median (25th, 75th percentiles): 3.9 mug/d (3.2, 7.2) vs. 8.1 mug/d (4.4, 12.3), p = 0.03) and at 6 years, fewer used vitamin D supplements regularly (23% vs. 56%, p = 0.03).	Vitamin D	60-69	immunoglobulin heavy constant epsilon	Homo sapiens	14-17
31340522-8	2019	At 12 months, IgE sensitized children had a lower intake of vitamin D (median (25th, 75th percentiles): 3.9 mug/d (3.2, 7.2) vs. 8.1 mug/d (4.4, 12.3), p = 0.03) and at 6 years, fewer used vitamin D supplements regularly (23% vs. 56%, p = 0.03).	Vitamin D	189-198	immunoglobulin heavy constant epsilon	Homo sapiens	14-17
31340522-9	2019	Introduction of solid foods prior to 4 months increased the odds of IgE-sensitization, OR = 4.9 (95%, CI = 1.4-16.6) and vitamin D supplement at 6 years decreased the odds of IgE-sensitization, OR = 0.2 (95%, CI = 0.1-0.98), adjusting for maternal smoking.	Vitamin D	121-130	immunoglobulin heavy constant epsilon	Homo sapiens	175-178
31330869-0	2019	Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro.	Vitamin D	0-9	interferon regulatory factor 3	Sus scrofa	99-103
31330899-7	2019	Subgroup-analyses of vitamin D insufficient subjects demonstrated a significant increase of LL-37 in the treatment group (p = 0.02), whereas treatment failed to significantly impact LL-37-levels in multiple regression analysis.	Vitamin D	21-30	cathelicidin antimicrobial peptide	Homo sapiens	92-97
31311491-1	2019	BACKGROUND: This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis factor, high sensitive C-reactive protein) and adipokines (adiponectin, leptin).	Vitamin D	71-80	C-reactive protein	Homo sapiens	240-258
31311491-1	2019	BACKGROUND: This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis factor, high sensitive C-reactive protein) and adipokines (adiponectin, leptin).	Vitamin D	71-80	adiponectin, C1Q and collagen domain containing	Homo sapiens	276-287
31292298-0	2019	Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.	Vitamin D	0-9	bone morphogenetic protein 2	Mus musculus	46-50
31295336-8	2019	Association of AmB/LE and vitamin D deficiency led to diminished glomerular filtration rate and increased tubular injury, evidenced by reduced renal protein expression of NaPi-IIa and TRPM6 leading to hyperphosphaturia / hypermagnesuria.	Vitamin D	26-35	solute carrier family 34 member 1	Rattus norvegicus	171-179
31284538-1	2019	Vitamin D deficiency or hypovitaminosis D is associated with increased risks of insulin resistance, type 2 diabetes mellitus (T2DM) and its related non-alcoholic fatty liver disease (NAFLD).	Vitamin D	0-9	insulin	Homo sapiens	80-87
31284538-3	2019	Our previous findings have shown that calcitriol, an active metabolite of vitamin D, reduces hepatic triglyceride accumulation and glucose output in diabetic db/db mice and human hepatocellular cell HepG2 cells under insulin-resistant conditions.	Vitamin D	74-83	insulin	Homo sapiens	217-224
31284538-4	2019	Notwithstanding the existence of this evidence, the protective action of vitamin D in the modulation of overexpressed RAS-induced metabolic abnormalities in the liver under insulin resistance remains to be elusive and investigated.	Vitamin D	73-82	insulin	Homo sapiens	173-180
31284538-5	2019	Herein, we have reported the potential interaction between vitamin D and RAS; and its beneficial effects on the expression and function of the RAS components in HepG2 cells and primary hepatocytes under insulin-resistance states.	Vitamin D	59-68	insulin	Homo sapiens	203-210
31284538-6	2019	Our study findings suggest that hormonal vitamin D (calcitriol) has modulatory action on the inappropriate upregulation of the hepatic RAS under insulin-resistant conditions.	Vitamin D	41-50	insulin	Homo sapiens	145-152
31354810-1	2019	Objective: This study aims to investigate the effect of combining calcium and vitamin D supplements with metformin on menstrual cycle abnormalities, gonadotropins, and IGF-1 system in vitamin D-deficient/insufficient PCOS women.	Vitamin D	78-87	insulin like growth factor 1	Homo sapiens	168-173
31354810-1	2019	Objective: This study aims to investigate the effect of combining calcium and vitamin D supplements with metformin on menstrual cycle abnormalities, gonadotropins, and IGF-1 system in vitamin D-deficient/insufficient PCOS women.	Vitamin D	184-193	insulin like growth factor 1	Homo sapiens	168-173
31354810-10	2019	Conclusions: Calcium and vitamin D supplements can support metformin effect on regulation of menstrual cycle irregularity in vitamin D-deficient/insufficient PCOS patients, but this effect is not associated with any significant changes in gonadotropins or IGF-1 system.	Vitamin D	25-34	insulin like growth factor 1	Homo sapiens	256-261
32010356-5	2019	The difference in insulin resistance between the patients determined as having severe vitamin D deficiency and vitamin D insufficiency was investigated.	Vitamin D	86-95	insulin	Homo sapiens	18-25
32010356-9	2019	Conclusion: Severe vitamin D deficiency had resulted in insulin resistance at a greater rate compared to vitamin D insufficiency in patients with non-diabetic chronic kidney disease (stage 2-3).	Vitamin D	19-28	insulin	Homo sapiens	56-63
30858148-1	2019	BACKGROUND: Vitamin D deficiency is common among dialysis patients and may impact blood concentrations of calcium, phosphorus, intact parathyroid hormone (iPTH), and alkaline phosphatase (ALP).	Vitamin D	12-21	parathyroid hormone	Homo sapiens	134-153
30858148-1	2019	BACKGROUND: Vitamin D deficiency is common among dialysis patients and may impact blood concentrations of calcium, phosphorus, intact parathyroid hormone (iPTH), and alkaline phosphatase (ALP).	Vitamin D	12-21	alkaline phosphatase, placental	Homo sapiens	166-186
30858148-1	2019	BACKGROUND: Vitamin D deficiency is common among dialysis patients and may impact blood concentrations of calcium, phosphorus, intact parathyroid hormone (iPTH), and alkaline phosphatase (ALP).	Vitamin D	12-21	alkaline phosphatase, placental	Homo sapiens	188-191
30959189-10	2019	In conclusion, supplementation with vitamin D appears to suppress bone turnover, possibly mediated by PTH reduction.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	102-105
31522448-6	2019	Vitamin D administration significantly reduced the monocyte chemoattractant protein (MCP)-1 concentrations in the HFD + vitamin D group compared with the HFD group and reduced liver Transforming growth factor beta (TGF-beta) levels in both vitamin D-treated groups (p&lt;0.05).	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	215-223
31522448-6	2019	Vitamin D administration significantly reduced the monocyte chemoattractant protein (MCP)-1 concentrations in the HFD + vitamin D group compared with the HFD group and reduced liver Transforming growth factor beta (TGF-beta) levels in both vitamin D-treated groups (p&lt;0.05).	Vitamin D	240-249	transforming growth factor, beta 1	Rattus norvegicus	215-223
31522448-7	2019	Moreover, a significant reduction in the serum levels of aspartate amino transferase (AST) and alanine amino transferase (ALT) in vitamin D treated groups was identified (p&lt;0.05).	Vitamin D	130-139	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	57-84
31522448-7	2019	Moreover, a significant reduction in the serum levels of aspartate amino transferase (AST) and alanine amino transferase (ALT) in vitamin D treated groups was identified (p&lt;0.05).	Vitamin D	130-139	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	86-89
31042050-4	2019	Moreover, administration of vitamin D also decreased NHE8 mRNA expression.	Vitamin D	28-37	solute carrier family 9 (sodium/hydrogen exchanger), member 8	Mus musculus	53-57
31173888-0	2019	Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4+ T cells in asthmatic patients.	Vitamin D	62-71	CD4 molecule	Homo sapiens	121-124
30600434-0	2019	Comparative study of testosterone and vitamin D analogue, elocalcitol, on insulin-controlled signal transduction pathway regulation in human skeletal muscle cells.	Vitamin D	38-47	insulin	Homo sapiens	74-81
31020672-8	2019	In stratified analysis, a significant positive association between vitamin D level and CVD was observed only in the high CRP group.	Vitamin D	67-76	C-reactive protein	Homo sapiens	121-124
31020672-10	2019	CONCLUSION: Within a cross-sectional, nationally representative sample, these findings suggest that vitamin D status evaluation, or vitamin D supplement may be especially important for individuals with high CRP levels.	Vitamin D	100-109	C-reactive protein	Homo sapiens	207-210
31020672-10	2019	CONCLUSION: Within a cross-sectional, nationally representative sample, these findings suggest that vitamin D status evaluation, or vitamin D supplement may be especially important for individuals with high CRP levels.	Vitamin D	132-141	C-reactive protein	Homo sapiens	207-210
30801902-0	2019	Vitamin D deficiency in the aetiology of obesity-related insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	57-64
30801902-4	2019	The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity.	Vitamin D	16-25	insulin	Homo sapiens	73-80
30801902-4	2019	The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity.	Vitamin D	16-25	insulin	Homo sapiens	192-199
30993889-1	2019	AIM: The aims of this study were to: (a) measure the proportion of CARTaGENE rheumatoid arthritis (RA) patients fulfilling pre-specified quality indicators (ie disease-modifying antirheumatic drug [DMARD] use, regular follow up, use of folate supplementation, use of vitamin D and calcium, exercise and smoking status); and (b) examine variation in DMARD use with respect to patient age, sex, education and income.	Vitamin D	267-276	CART prepropeptide	Homo sapiens	67-76
30801902-4	2019	The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity.	Vitamin D	39-48	insulin	Homo sapiens	73-80
30801902-5	2019	Indeed, mainly in vitro studies support a role of vitamin D in regulating glucose and lipid metabolism in several insulin-sensitive tissues including adipose tissue, skeletal muscle, liver, as well as pancreatic insulin secretion.	Vitamin D	50-59	insulin	Homo sapiens	114-121
30801902-7	2019	This review summarizes recent knowledge on vitamin D deficiency in the aetiology of obesity-related insulin resistance and discusses potential underlying mechanisms.	Vitamin D	43-52	insulin	Homo sapiens	100-107
30801902-8	2019	Finally, the role of vitamin D supplementation on insulin sensitivity and glycaemic control is discussed.	Vitamin D	21-30	insulin	Homo sapiens	50-57
31741900-1	2019	Context: There is no consensus about the inflection point for 25 hydroxy vitamin D below which the intact PTH level increases.	Vitamin D	62-82	parathyroid hormone	Homo sapiens	106-109
31741900-6	2019	An inverse relationship between 25 hydroxy vitamin D (25(OH)D) and intact PTH exist, but strength of such relationship is weak (r = -0.16, P = 0.018).	Vitamin D	32-52	parathyroid hormone	Homo sapiens	74-77
30993743-0	2019	Family-based Association between Allele T of rs4646536 in CYP27B1 and vitamin D deficiency.	Vitamin D	70-79	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	58-65
30993743-1	2019	BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D.	Vitamin D	87-96	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	161-168
30993743-3	2019	We aimed at investigating the family-based association between SNPs of CYP2R1 and CYP27B1 and vitamin D deficiency.	Vitamin D	94-103	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	82-89
30993743-7	2019	RESULTS: The results of the pilot case-control study indicated that both CT and TT genotypes of rs4646536 in CYP27B1 could increase the susceptibility of vitamin D deficiency when compared with CC genotype.	Vitamin D	154-163	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	109-116
31266190-2	2019	Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies documented an inverse correlation between circulating vitamin D levels, central adiposity and the development of insulin resistance and diabetes.	Vitamin D	223-232	insulin	Homo sapiens	282-289
31266190-2	2019	Obesity and impaired glucose homeostasis are closely related, and during the last decades of investigation about vitamin D, several clinical and epidemiological studies documented an inverse correlation between circulating vitamin D levels, central adiposity and the development of insulin resistance and diabetes.	Vitamin D	113-122	insulin	Homo sapiens	282-289
31266190-3	2019	The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.	Vitamin D	165-174	insulin	Homo sapiens	212-219
31266190-3	2019	The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.	Vitamin D	165-174	insulin	Homo sapiens	231-238
31266190-3	2019	The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.	Vitamin D	165-174	insulin	Homo sapiens	231-238
31266190-3	2019	The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.	Vitamin D	165-174	insulin	Homo sapiens	212-219
30058048-0	2019	Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?	Vitamin D	65-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	26-31
31266190-3	2019	The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.	Vitamin D	165-174	insulin	Homo sapiens	231-238
30058048-1	2019	CYP3A enzymes are involved in the metabolism of calcineurin inhibitor tacrolimus as well as vitamin D.	Vitamin D	92-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-5
31266190-3	2019	The insufficient sun exposure and outdoor activities of obese individuals, the storage of vitamin D in adipose tissue, because of its lipophilic properties, and the vitamin D-mediated modulation of adipogenesis, insulin secretion, insulin sensitivity and the immune system, are the main reasons for the close relationship between obesity, glucose homeostasis and hypovitaminosis D. Then objective of this review is to explore the pathophysiological mechanism(s) by which vitamin D modulates glycemic control and insulin sensitivity in obese individuals.	Vitamin D	165-174	insulin	Homo sapiens	231-238
31305932-7	2019	On the other hand, current CD4+ lymphocyte count &gt;600 cells/mm3 and current HIV RNA &lt;20 copies/mL were significantly associated with a lower risk of vitamin D deficiency.	Vitamin D	155-164	CD4 molecule	Homo sapiens	27-30
31293618-5	2019	In this study, we analyzed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor, including FCER1A, MS4A2, FCER1G, VDR, GC, CYP2R1, CYP27A1, CYP27B1, CYP24A1, RXRA, RXRB, RXRG, IL4, IL4R, IL13, and IL13RA1.	Vitamin D	73-82	membrane spanning 4-domains A2	Homo sapiens	145-150
31288897-0	2019	Vitamin D attenuates lipopolysaccharide-induced inflammatory response in endothelial cells through inhibition of PI3K/Akt/NF-kappaB signaling pathway.	Vitamin D	0-9	AKT serine/threonine kinase 1	Homo sapiens	118-121
31288897-0	2019	Vitamin D attenuates lipopolysaccharide-induced inflammatory response in endothelial cells through inhibition of PI3K/Akt/NF-kappaB signaling pathway.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	122-131
31200560-1	2019	BACKGROUND: Research evidence indicates that vitamin D deficiency is involved in the pathogenesis of insulin resistance (IR) and associated metabolic disorders including hyperglycemia and dyslipidemia.	Vitamin D	45-54	insulin	Homo sapiens	101-108
31234506-2	2019	The active form of vitamin D functions through the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor a	Danio rerio	51-69
31234506-2	2019	The active form of vitamin D functions through the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor a	Danio rerio	71-74
31281179-9	2019	At the molecular levels, administration of vitamin D activated the expression of VDR and reduced the number of dead cells in the CA1 region of the hippocampus as well as regulated caspase-3 and Bcl-2 expression.	Vitamin D	43-52	B cell leukemia/lymphoma 2	Mus musculus	194-199
31384716-1	2019	The increased prevalence of vitamin D [25(OH)D] deficiency in type 1 diabetes mellitus (T1DM) may be related to low insulin levels in the hepatic portal venous system.	Vitamin D	28-37	insulin	Homo sapiens	116-123
31200560-0	2019	Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with Metabolic Disorders.	Vitamin D	0-9	insulin	Homo sapiens	64-71
31177749-14	2019	Insulin resistance has a mediating effect on the relationship of vitamin D and the risk of type 2 diabetes.	Vitamin D	65-74	insulin	Homo sapiens	0-7
31176378-8	2019	Skin fold thickness, fasting and post-glucose insulin, HOMA-IR, PTH, LDL, Serum cholesterol and hs-CRP showed statistically significant negative correlations with Vitamin D levels.	Vitamin D	163-172	parathyroid hormone	Homo sapiens	64-67
31176378-8	2019	Skin fold thickness, fasting and post-glucose insulin, HOMA-IR, PTH, LDL, Serum cholesterol and hs-CRP showed statistically significant negative correlations with Vitamin D levels.	Vitamin D	163-172	C-reactive protein	Homo sapiens	99-102
29885777-7	2019	RESULTS: In models adjusting for time-dependent viral load and baseline CD4 count, age, sex, body mass index, country, treatment regimen, anemia and hypoalbuminemia status, pre-cART vitamin D deficiency was associated with lower CD4 recovery (-14.9 cells/mm3, 95% CI: -27.9, -1.8) compared to sufficiency.	Vitamin D	182-191	CD4 molecule	Homo sapiens	229-232
29885777-9	2019	CONCLUSIONS: In summary, baseline vitamin D deficiency was associated with diminished CD4 recovery after cART initiation; impaired CD4 recovery may contribute to the poor clinical outcomes recently observed in individuals with vitamin D deficiency.	Vitamin D	34-43	CD4 molecule	Homo sapiens	86-89
29885777-9	2019	CONCLUSIONS: In summary, baseline vitamin D deficiency was associated with diminished CD4 recovery after cART initiation; impaired CD4 recovery may contribute to the poor clinical outcomes recently observed in individuals with vitamin D deficiency.	Vitamin D	227-236	CD4 molecule	Homo sapiens	131-134
30097651-10	2019	After adjustment for lipid markers, age, and gender, vitamin D deficiency was associated with increased odds of CRP, eGFR, gammaGT, FPG, HbA1c, and the surrogate for CVD.	Vitamin D	53-62	C-reactive protein	Homo sapiens	112-115
30097651-10	2019	After adjustment for lipid markers, age, and gender, vitamin D deficiency was associated with increased odds of CRP, eGFR, gammaGT, FPG, HbA1c, and the surrogate for CVD.	Vitamin D	53-62	epidermal growth factor receptor	Homo sapiens	117-121
30097651-11	2019	CONCLUSIONS: In this exploratory analysis, the first of its kind in the MENA region, vitamin D deficiency was associated with abnormal lipid markers, non-lipid markers of CVD, male gender, lower eGFR, and a surrogate variable for CVD.	Vitamin D	85-94	ENAH actin regulator	Homo sapiens	72-76
30097651-11	2019	CONCLUSIONS: In this exploratory analysis, the first of its kind in the MENA region, vitamin D deficiency was associated with abnormal lipid markers, non-lipid markers of CVD, male gender, lower eGFR, and a surrogate variable for CVD.	Vitamin D	85-94	epidermal growth factor receptor	Homo sapiens	195-199
31151163-10	2019	Optimal supplementation of vitamin D, along with rich dietary sources of vitamin D, are highly recommended for older subjects as a means to positively affect, e.g., hypertension, insulin resistance, and obesity, as components of the MetS.	Vitamin D	27-36	insulin	Homo sapiens	179-186
31261480-0	2019	A case of vitamin D hydroxylation-deficient rickets type 1A caused by 2 novel pathogenic variants in CYP27B1 gene.	Vitamin D	10-19	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	101-108
31231498-11	2019	Conclusion: Vitamin D might contribute in ameliorating diabetes complications not only by improving blood glucose and insulin levels, but also by suppressing AGER and OGT gene expression in the liver.	Vitamin D	12-21	advanced glycosylation end product-specific receptor	Rattus norvegicus	158-162
30937698-6	2019	Conversely, Vitamin D increases glial tumor synthesis of neutrophins NGF and NT-3, the low affinity neurotrophin receptor p75NTR, IL-6 and VEGF, which may enhance glioma growth.	Vitamin D	12-21	interleukin 6	Homo sapiens	130-134
30937698-6	2019	Conversely, Vitamin D increases glial tumor synthesis of neutrophins NGF and NT-3, the low affinity neurotrophin receptor p75NTR, IL-6 and VEGF, which may enhance glioma growth.	Vitamin D	12-21	vascular endothelial growth factor A	Homo sapiens	139-143
30937698-8	2019	Hence, we hypothesize that Calcitriol + ATRA (All-Trans Retinoic Acid) + Temozolomide - CAT combination might be a safer approach to benefit from Vitamin D in the management of high-grade glial tumors.	Vitamin D	146-155	catalase	Homo sapiens	88-91
30623714-0	2019	Effect of vitamin D deficiency on the 75 g oral glucose tolerance test screening and insulin resistance.	Vitamin D	10-19	insulin	Homo sapiens	85-92
30612423-0	2019	Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	105-112
30612423-1	2019	BACKGROUND: The aim of f this study is to investigate the effect of vitamin D supplementation upon the outcome of in-vitro fertilization (IVF) in infertile women with polycystic ovarian syndrome (PCOS) and insulin resistance (IR).	Vitamin D	68-77	insulin	Homo sapiens	206-213
31151163-10	2019	Optimal supplementation of vitamin D, along with rich dietary sources of vitamin D, are highly recommended for older subjects as a means to positively affect, e.g., hypertension, insulin resistance, and obesity, as components of the MetS.	Vitamin D	73-82	insulin	Homo sapiens	179-186
31275989-13	2019	Conclusions: siVDR, AKT inhibitor, and UCP2 inhibitor elevated the ROS and apoptosis of HK2 cells while attenuating the mitochondrial membrane potential, suggesting that vitamin D protects renal tubular cell from high glucose by AKT/UCP2 signaling pathway.	Vitamin D	170-179	AKT serine/threonine kinase 1	Homo sapiens	20-23
31032644-6	2019	Vitamin D supplementation in patients with CHF improved health-related quality of life and C-reactive protein levels [weighted mean difference (WMD): 6.75, 95% confidence interval (CI): 2.87 to 10.64, p &lt; .001; standardised mean difference (SMD): -0.41, 95% CI: -0.71 to -0.11, p = .007].	Vitamin D	0-9	C-reactive protein	Homo sapiens	91-109
31275989-0	2019	Active Vitamin D and Vitamin D Receptor Help Prevent High Glucose Induced Oxidative Stress of Renal Tubular Cells via AKT/UCP2 Signaling Pathway.	Vitamin D	7-16	AKT serine/threonine kinase 1	Homo sapiens	118-121
31275989-13	2019	Conclusions: siVDR, AKT inhibitor, and UCP2 inhibitor elevated the ROS and apoptosis of HK2 cells while attenuating the mitochondrial membrane potential, suggesting that vitamin D protects renal tubular cell from high glucose by AKT/UCP2 signaling pathway.	Vitamin D	170-179	AKT serine/threonine kinase 1	Homo sapiens	229-232
31275989-2	2019	We here tested the hypothesis that active vitamin D is able to up-regulate AKT/UCP2 signaling to alleviate oxidative stress of renal tubular cell line HK2.	Vitamin D	42-51	AKT serine/threonine kinase 1	Homo sapiens	75-78
31179282-1	2019	Vitamin D possesses renoprotective effects beyond mineral metabolism, potentially reducing arterial blood pressure and inflammation and vitamin D enzymes (CYP24A1 and CYP27B1) as well as vitamin D receptor (VDR) contribute to its homeostasis.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	167-174
31191450-1	2019	This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions.	Vitamin D	54-63	D site albumin promoter binding protein	Mus musculus	81-84
31191450-5	2019	Although DBP has a number of biologic functions independent of vitamin D, its major biologic function is that of regulating circulating free and total levels of vitamin D metabolites.	Vitamin D	161-170	D site albumin promoter binding protein	Mus musculus	9-12
31191450-9	2019	This hypothesis is supported by the observation that mice lacking DBP, and therefore with essentially undetectable 25(OH)D levels, do not show signs of vitamin D deficiency unless put on a vitamin D deficient diet.	Vitamin D	189-198	D site albumin promoter binding protein	Mus musculus	66-69
31137600-0	2019	Reduced Serum Vitamin D Levels Are Associated with Insulin Resistance in Patients with Obstructive Sleep Apnea Syndrome.	Vitamin D	14-23	insulin	Homo sapiens	51-58
31121922-2	2019	Vitamin D presents a pleiotropic action, and can regulate insulin secretion and inflammatory responses.	Vitamin D	0-9	insulin	Homo sapiens	58-65
31137600-2	2019	Furthermore, OSAS has been associated with decreased levels of vitamin D (Vit D).	Vitamin D	63-72	vitrin	Homo sapiens	74-77
31100793-12	2019	Vitamin D supplementation was associated with a decrease in fasting blood glucose by a mean of 0.46 mmol/L (-0.68, -0.25) (p < 0.001), glycated haemoglobin by a mean of 0.37% (-0.65, -0.08) (p < 0.01) and serum insulin concentration by mean of 4.10 microIU/mL (-5.50, -2.71) (p < 0.001) compared to controls.	Vitamin D	0-9	insulin	Homo sapiens	211-218
30661440-7	2019	Specifically, pharmacological inhibition of autophagy increased UV-induced apoptosis, suppressed M2 macs recruitment, and prevented vitamin D downregulation of Tnf and Mmp9 in the skin.	Vitamin D	132-141	tumor necrosis factor	Mus musculus	160-163
31061425-0	2019	The dynamic relationships between the active and catabolic vitamin D metabolites, their ratios, and associations with PTH.	Vitamin D	59-68	parathyroid hormone	Homo sapiens	118-121
31061425-6	2019	Our three-dimensional model provides mechanistic insight into the vitamin D-PTH endocrine system, and further substantiates the role of 24,25(OH)2D in human physiology.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	76-79
31061425-7	2019	The model sets a new paradigm for vitamin D treatment strategy, and may help the establishment of vitamin D-adjusted PTH reference intervals.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	117-120
31061425-7	2019	The model sets a new paradigm for vitamin D treatment strategy, and may help the establishment of vitamin D-adjusted PTH reference intervals.	Vitamin D	98-107	parathyroid hormone	Homo sapiens	117-120
31110524-0	2019	Effects of vitamin D supplementation on insulin resistance and dyslipidemia in overweight and obese premenopausal women.	Vitamin D	11-20	insulin	Homo sapiens	40-47
31193780-0	2019	DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism.	Vitamin D	31-40	sclerostin	Homo sapiens	65-75
31193780-1	2019	Aim: To study the relationship between obesity, insulin resistance, vitamin D deficiency and sclerostin as a bone biomarker.	Vitamin D	68-77	sclerostin	Homo sapiens	93-103
31193780-6	2019	Conclusion: These results lead us to hypothesize that the relationship between sclerostin and Vitamin D levels has an important role in the link between obesity and bone metabolism.	Vitamin D	94-103	sclerostin	Homo sapiens	79-89
31205465-0	2019	Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-gamma Functional Module of Autophagy in Rheumatoid Arthritis.	Vitamin D	33-42	peroxisome proliferator activated receptor gamma	Homo sapiens	69-79
30661440-8	2019	Furthermore, selective deletion of autophagy in myeloid cells of atg7 cKO mice abrogated vitamin D-mediated protection and recapitulated UV-induced inflammation.	Vitamin D	89-98	autophagy related 7	Mus musculus	65-69
30661440-9	2019	Mechanistically, vitamin D signaling activated M2-autophagy regulators Klf4, Pparg, and Arg1.	Vitamin D	17-26	Kruppel-like factor 4 (gut)	Mus musculus	71-75
31001917-0	2019	Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.	Vitamin D	14-23	epidermal growth factor receptor	Homo sapiens	83-87
30833469-8	2019	Moreover, fasting upregulated the vitamin D catabolizing CYP24A1 in the kidney through the PGC-1alpha-ERRalpha pathway.	Vitamin D	34-43	estrogen related receptor, alpha	Mus musculus	102-110
30959477-0	2019	The effect of vitamin D supplementation on plasma non-oxidised PTH in a randomised clinical trial.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	63-66
30959477-3	2019	While vitamin D supplementation decreases total PTH (tPTH) concentration, the effect on n-oxPTH concentration is unexplored.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	48-51
30959477-10	2019	Our study suggests that vitamin D supplementation reduces the oxidation of PTH, as we observed a small but significant increase in the non-oxidised proportion of PTH upon treatment.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	75-78
30959477-10	2019	Our study suggests that vitamin D supplementation reduces the oxidation of PTH, as we observed a small but significant increase in the non-oxidised proportion of PTH upon treatment.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	162-165
31071733-9	2019	Furthermore, we found that high doses of vitamin D and calcium co-supplementation (vitamin D&gt;=2000 mg/day and calcium&gt;=1000 mg/day) had significantly reducing effects on FBG, HOMA-IR and insulin.	Vitamin D	83-92	insulin	Homo sapiens	181-200
31071733-10	2019	Present meta-analysis indicated the beneficial effects of high-dose and short-term combined vitamin D and calcium supplementation on insulin, insulin resistance and glycemia; however, further large-scale RCTs with adequate and multiple dosing schedules are needed.	Vitamin D	92-101	insulin	Homo sapiens	133-140
31071733-10	2019	Present meta-analysis indicated the beneficial effects of high-dose and short-term combined vitamin D and calcium supplementation on insulin, insulin resistance and glycemia; however, further large-scale RCTs with adequate and multiple dosing schedules are needed.	Vitamin D	92-101	insulin	Homo sapiens	142-149
30729713-2	2019	The aim of this study is to determine the clinical factors of vitamin D deficiency in multi-ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL-6 levels.	Vitamin D	62-71	interleukin 6	Homo sapiens	196-200
30737643-11	2019	For calcium (Ca) and parathyroid hormone (PTH), there was a significant difference between the vitamin D group and the placebo group.	Vitamin D	95-104	parathyroid hormone	Homo sapiens	21-40
30737643-11	2019	For calcium (Ca) and parathyroid hormone (PTH), there was a significant difference between the vitamin D group and the placebo group.	Vitamin D	95-104	parathyroid hormone	Homo sapiens	42-45
30470577-2	2019	DESIGN: Longitudinal study examining the relationship between vitamin D levels at baseline (wave 1) and incident depression at 2 and 4 years (waves 2 and 3), embedded within the Irish Longitudinal Study on Aging.	Vitamin D	62-71	WASP family member 1	Homo sapiens	92-98
30772337-0	2019	Association of vitamin D deficiency with insulin resistance in middle-aged type 2 diabetics.	Vitamin D	15-24	insulin	Homo sapiens	41-48
30772337-1	2019	BACKGROUND: Vitamin D deficiency contributes to the pathophysiology of insulin resistance (IR) and type 2 diabetes mellitus (T2DM).	Vitamin D	12-21	insulin	Homo sapiens	71-78
31115227-1	2019	BACKGROUND: Various studies have been reported on the relationship between vitamin D, whose deficiency has been identified in a pandemic way, and metabolic-endocrine diseases, including insulin resistance.	Vitamin D	75-84	insulin	Homo sapiens	186-193
31115227-6	2019	The relationship between serum vitamin D levels and insulin resistance was compared between the groups.	Vitamin D	31-40	insulin	Homo sapiens	52-59
30698894-0	2019	Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner.	Vitamin D	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
31148851-12	2019	When insulin resistance or obesity was present, vitamin D levels were reduced further.	Vitamin D	48-57	insulin	Homo sapiens	5-12
31071733-6	2019	Results demonstrated that calcium and vitamin D co-supplementation had significantly reducing effects on FBG, HOMA-IR and circulating levels of insulin.	Vitamin D	38-47	insulin	Homo sapiens	144-151
31071733-8	2019	However, beneficial effects of calcium and vitamin D co-supplementation on circulating level of insulin and HOMA-IR were seen in both short-term and long-term (&gt;12 weeks) supplementations.	Vitamin D	43-52	insulin	Homo sapiens	96-103
31071733-9	2019	Furthermore, we found that high doses of vitamin D and calcium co-supplementation (vitamin D&gt;=2000 mg/day and calcium&gt;=1000 mg/day) had significantly reducing effects on FBG, HOMA-IR and insulin.	Vitamin D	41-50	insulin	Homo sapiens	181-200
31934009-0	2019	Vitamin D deficiency enhances insulin resistance by promoting inflammation in type 2 diabetes.	Vitamin D	0-9	insulin	Homo sapiens	30-37
31934009-7	2019	Vitamin D deficiency could increase the inflammatory response by up-regulating p-p65/RelB in the pancreas tissue.	Vitamin D	0-9	RELB proto-oncogene, NF-kB subunit	Homo sapiens	85-89
31934009-8	2019	CONCLUSION: Serum 25(OH)D was elevated and Vitamin D deficiency enhanced insulin resistance by promoting inflammation via NF-kB pathway in patients with T2DM.	Vitamin D	43-52	insulin	Homo sapiens	73-80
30690074-0	2019	Vitamin D (1,25(OH)2D3) induces alpha-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.	Vitamin D	0-9	serpin family A member 1	Homo sapiens	32-51
31223605-0	2019	Preventive Effects of Low Parathyroid Hormone Levels on Hip Fracture in Patients with Vitamin D Deficiency.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	26-45
31223605-1	2019	Background: The objective of the current study is to determine the role of serum parathyroid hormone (PTH) on hip fracture development by retrospectively analyzing the relationship between vitamin D and PTH levels and hip fracture prevalence.	Vitamin D	189-198	parathyroid hormone	Homo sapiens	81-100
31223605-1	2019	Background: The objective of the current study is to determine the role of serum parathyroid hormone (PTH) on hip fracture development by retrospectively analyzing the relationship between vitamin D and PTH levels and hip fracture prevalence.	Vitamin D	189-198	parathyroid hormone	Homo sapiens	102-105
31223605-8	2019	Conclusions: Patients with low serum 25(OH)D and PTH levels showed lower hip fracture prevalence, indicating the potential protective role of low PTH levels on bone health in patients with vitamin D deficiency.	Vitamin D	189-198	parathyroid hormone	Homo sapiens	49-52
31223605-8	2019	Conclusions: Patients with low serum 25(OH)D and PTH levels showed lower hip fracture prevalence, indicating the potential protective role of low PTH levels on bone health in patients with vitamin D deficiency.	Vitamin D	189-198	parathyroid hormone	Homo sapiens	146-149
31223605-9	2019	Therefore, clinicians should pay more attention to the possibility of fractures in patients with vitamin D deficiency who present with high PTH levels.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	140-143
31226177-0	2019	PURL: Can vitamin D prevent acute respiratory infections?	Vitamin D	10-19	phosphoribosylformylglycinamidine synthase	Homo sapiens	0-4
31551213-2	2019	Vitamin D may be a good therapeutic option for NAFLD patients due to its insulin sensitizing and anti-inflammatory properties.	Vitamin D	0-9	insulin	Homo sapiens	73-80
31085128-6	2019	An initial relatively weak IRF-mediated response to DNA from HN878 and H37Rv increased if the cells were pre-treated with Vitamin D (Vit D) for 72 h. RNAseq of THP-1 under different transformation conditions showed that pre-treatment with Vit D upregulated several TLR9 variants, as well as genes involved in inflammatory immune response to infection, immune cell activation, Type I IFN regulation, and regulation of inflammation.	Vitamin D	122-131	GLI family zinc finger 2	Homo sapiens	160-165
31085128-6	2019	An initial relatively weak IRF-mediated response to DNA from HN878 and H37Rv increased if the cells were pre-treated with Vitamin D (Vit D) for 72 h. RNAseq of THP-1 under different transformation conditions showed that pre-treatment with Vit D upregulated several TLR9 variants, as well as genes involved in inflammatory immune response to infection, immune cell activation, Type I IFN regulation, and regulation of inflammation.	Vitamin D	133-138	GLI family zinc finger 2	Homo sapiens	160-165
31245047-10	2019	In multivariable models, controlling for age, sex, SE, smoking and vitamin D deficiency, LL37 level (top quartile) associated with anti-CCP seropositivity (OR 22; 95% CI 4 to 104).	Vitamin D	67-76	cathelicidin antimicrobial peptide	Homo sapiens	89-93
31127822-0	2019	Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs.	Vitamin D	11-20	insulin	Homo sapiens	70-79
31127822-1	2019	CONTEXT: Vitamin D may be important for prenatal programming of insulin and glucose regulation, but maternal vitamin D deficiency during pregnancy is common.	Vitamin D	9-18	insulin	Homo sapiens	64-71
31127822-11	2019	CONCLUSIONS: Vitamin D may play a role in regulating fetal insulin secretion, potentially impacting glucose regulation and growth.	Vitamin D	13-22	insulin	Homo sapiens	59-66
30997616-0	2019	Acupuncture and Vitamin D for the Management of Aromatase Inhibitor-Induced Arthralgia.	Vitamin D	16-25	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	48-57
31105857-0	2019	Vitamin D retards intervertebral disc degeneration through inactivation of the NF-kappaB pathway in mice.	Vitamin D	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
31105857-7	2019	In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway.	Vitamin D	221-230	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
31105857-7	2019	In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway.	Vitamin D	221-230	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	293-302
31105857-7	2019	In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway.	Vitamin D	264-273	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
31105857-8	2019	Vitamin D retarded intervertebral disc degeneration by inhibiting NF-kappaB pathway, which may relieve inflammatory reactions, resist oxidative stress, inhibit apoptosis and delay cell senescence.	Vitamin D	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
30959886-0	2019	Analysis of Association between Vitamin D Deficiency and Insulin Resistance.	Vitamin D	32-41	insulin	Homo sapiens	57-64
30959886-2	2019	It is worth noting that vitamin D deficiency is very common and may be associated with the pathogenesis of insulin-resistance-related diseases, including obesity and diabetes.	Vitamin D	24-33	insulin	Homo sapiens	107-114
30959886-3	2019	This review aims to provide molecular mechanisms showing how vitamin D deficiency may be involved in the insulin resistance formation.	Vitamin D	61-70	insulin	Homo sapiens	105-112
30959886-5	2019	It was identified that molecular action of vitamin D is involved in maintaining the normal resting levels of ROS and Ca2+, not only in pancreatic beta-cells, but also in insulin responsive tissues.	Vitamin D	43-52	insulin	Homo sapiens	170-177
30959886-6	2019	Both genomic and non-genomic action of vitamin D is directed towards insulin signaling.	Vitamin D	39-48	insulin	Homo sapiens	69-76
30959886-7	2019	Thereby, vitamin D reduces the extent of pathologies associated with insulin resistance such as oxidative stress and inflammation.	Vitamin D	9-18	insulin	Homo sapiens	69-76
30959886-8	2019	More recently, it was also shown that vitamin D prevents epigenetic alterations associated with insulin resistance and diabetes.	Vitamin D	38-47	insulin	Homo sapiens	96-103
30959886-9	2019	In conclusion, vitamin D deficiency is one of the factors accelerating insulin resistance formation.	Vitamin D	15-24	insulin	Homo sapiens	71-78
30959886-10	2019	The results of basic and clinical research support beneficial action of vitamin D in the reduction of insulin resistance and related pathologies.	Vitamin D	72-81	insulin	Homo sapiens	102-109
30670337-3	2019	Vitamin D is known to induce antimicrobial peptides, protect intestinal flora, enhance the gut epithelial barrier, suppress mast cell activation and IgE synthesis from B cells, and increase the number of tolerogenic dendritic cells and IL-10-producing regulatory T cells.	Vitamin D	0-9	interleukin 10	Mus musculus	236-241
29752008-13	2019	Interestingly, the Hs-CRP was reduced in AA carries while was elevated in individuals with GG and AG genotypes, after high-dose vitamin D supplementation.	Vitamin D	128-137	C-reactive protein	Homo sapiens	22-25
30639520-12	2019	These data suggest a key role of vitamin D in the control of inflammatory cytokine responses during DENV infection of human macrophages via the TLR4/NF-kappaB/miR-155-5p/SOCS-1 axis.	Vitamin D	33-42	nuclear factor kappa B subunit 1	Homo sapiens	149-158
30508646-0	2019	Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.	Vitamin D	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
30414721-9	2019	In the psychosis group, levels of IL-6 correlated positively with IgA anti-LPS antibodies and negatively correlated with vitamin D.	Vitamin D	121-130	interleukin 6	Homo sapiens	34-38
30414721-10	2019	CONCLUSIONS: Our findings show a significant correlation between IL-6, anti-LPS antibodies and vitamin D deficiency in psychosis, suggesting the existence of multiple potential pathways related to IL-6 elevation in psychosis, and therefore multiple potential strategies for risk mitigation.	Vitamin D	95-104	interleukin 6	Homo sapiens	65-69
30414721-10	2019	CONCLUSIONS: Our findings show a significant correlation between IL-6, anti-LPS antibodies and vitamin D deficiency in psychosis, suggesting the existence of multiple potential pathways related to IL-6 elevation in psychosis, and therefore multiple potential strategies for risk mitigation.	Vitamin D	95-104	interleukin 6	Homo sapiens	197-201
30934881-3	2019	We therefore examined vitamin D effects on BTMs (beta-cross laps (CTX) and osteocalcin (OC)) and BMD in a post-hoc analysis of a randomized controlled trial (RCT).	Vitamin D	22-31	bone gamma-carboxyglutamate protein	Homo sapiens	75-86
30944814-0	2019	High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	77-96
30944814-9	2019	Conclusions: Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in CLD.	Vitamin D	128-137	parathyroid hormone	Homo sapiens	124-127
30874583-4	2019	In contrast to cultivation in conventional tissue culture settings, on-chip cultivation of HepG2 and RPTEC cells in interconnected chambers, used to mimic the liver and kidneys, respectively, resulted in the enhanced expression of vitamin D metabolizing enzymes (CYP2R1, CYP27B1 and CYP24A1).	Vitamin D	231-240	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	271-278
30845908-2	2019	Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destruction of insulin producing beta cells in T1DM patients.	Vitamin D	0-9	insulin	Homo sapiens	119-126
30540559-13	2019	Parathyroid hormone replacement is of value in lowering the doses of calcium and active vitamin D analogues required and may be of value in lowering long term complications of hypoparathyroidism.	Vitamin D	88-97	parathyroid hormone	Homo sapiens	0-19
30881343-7	2019	The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency.	Vitamin D	122-131	adiponectin, C1Q and collagen domain containing	Homo sapiens	60-71
30881343-7	2019	The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency.	Vitamin D	147-156	adiponectin, C1Q and collagen domain containing	Homo sapiens	60-71
30880828-8	2019	A significant positive correlation was observed between vitamin D and osteocalcin levels (r = 0.198; p = 0.008).	Vitamin D	56-65	bone gamma-carboxyglutamate protein	Homo sapiens	70-81
30880828-13	2019	Vitamin D may directly improve serum lipid profiles and may indirectly decrease insulin resistance and subclinical systemic inflammation through the impact on the metabolic functions of osteocalcin.	Vitamin D	0-9	insulin	Homo sapiens	80-87
30880828-13	2019	Vitamin D may directly improve serum lipid profiles and may indirectly decrease insulin resistance and subclinical systemic inflammation through the impact on the metabolic functions of osteocalcin.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	186-197
30255482-6	2019	Preclinical studies of vitamin D action on insulin secretion, insulin action, inflammatory processes, and immune regulation, along with evidence of an increase of hypovitaminosis D worldwide, have prompted several epidemiological, observational, and supplementation clinical studies investigating a potential biological interaction between hypovitaminosis D and diabetes.	Vitamin D	23-32	insulin	Homo sapiens	43-50
30255482-6	2019	Preclinical studies of vitamin D action on insulin secretion, insulin action, inflammatory processes, and immune regulation, along with evidence of an increase of hypovitaminosis D worldwide, have prompted several epidemiological, observational, and supplementation clinical studies investigating a potential biological interaction between hypovitaminosis D and diabetes.	Vitamin D	23-32	insulin	Homo sapiens	62-69
31161106-5	2019	Results: Anthropometric metabolic markers like BMI, WC, waist to height ratio and biochemical parameters like total cholesterol, LDL, TG, insulin, ALT, FPG were statistically significantly higher in vitamin D deficient (&lt;20 ng/ml) (n = 228) subjects compared to Vitamin D non-deficient subjects (&gt;=20 ng/ml) (n = 177) which persisted even after adjustment for BMI except for FPG.	Vitamin D	199-208	insulin	Homo sapiens	138-145
31089432-1	2019	Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia.	Vitamin D	79-88	parathyroid hormone	Homo sapiens	126-129
31089432-1	2019	Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	126-129
30668811-0	2019	Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	28-35
31084433-6	2019	Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues.	Vitamin D	40-49	interferon gamma	Homo sapiens	130-139
30477283-5	2019	RESULTS: In 88 patients with Crohn"s disease (CD), a negative correlation was found between serum vitamin D and CRP.	Vitamin D	98-107	C-reactive protein	Homo sapiens	112-115
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	interleukin 6	Homo sapiens	20-24
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	74-82
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	86-94
30946322-6	2019	Meta-analysis results showed that compared with the control group, the short-term vitamin D supplementation group had a decline in hemoglobin A1c (HbA1c), insulin resistance, and insulin.	Vitamin D	82-91	insulin	Homo sapiens	155-162
30946322-6	2019	Meta-analysis results showed that compared with the control group, the short-term vitamin D supplementation group had a decline in hemoglobin A1c (HbA1c), insulin resistance, and insulin.	Vitamin D	82-91	insulin	Homo sapiens	179-186
30946322-9	2019	CONCLUSION: Vitamin D supplementation in T2D patients can improve HbA1c, insulin resistance, and insulin in short-term intervention, suggesting that vitamin D can be considered as a therapeutic agent along with the other treatments for T2D.	Vitamin D	12-21	insulin	Homo sapiens	73-80
30946322-9	2019	CONCLUSION: Vitamin D supplementation in T2D patients can improve HbA1c, insulin resistance, and insulin in short-term intervention, suggesting that vitamin D can be considered as a therapeutic agent along with the other treatments for T2D.	Vitamin D	12-21	insulin	Homo sapiens	97-104
30946322-9	2019	CONCLUSION: Vitamin D supplementation in T2D patients can improve HbA1c, insulin resistance, and insulin in short-term intervention, suggesting that vitamin D can be considered as a therapeutic agent along with the other treatments for T2D.	Vitamin D	149-158	insulin	Homo sapiens	73-80
30946322-9	2019	CONCLUSION: Vitamin D supplementation in T2D patients can improve HbA1c, insulin resistance, and insulin in short-term intervention, suggesting that vitamin D can be considered as a therapeutic agent along with the other treatments for T2D.	Vitamin D	149-158	insulin	Homo sapiens	97-104
30653195-4	2019	This is the major circulating form of vitamin D and keeps an inverse correlation with serum parathyroid hormone (PTH) concentration.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	92-111
30927339-3	2019	Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D.	Vitamin D	166-175	parathyroid hormone	Homo sapiens	0-19
30927339-3	2019	Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D.	Vitamin D	166-175	parathyroid hormone	Homo sapiens	21-24
30659895-8	2019	RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels.	Vitamin D	9-13	actin alpha 1, skeletal muscle	Homo sapiens	158-163
30770424-8	2019	Participants with &gt;=1 APOE epsilon4 allele were more likely to develop delirium (e.g., epsilon4epsilon4 hazard ratio = 3.73, 95% confidence interval 2.68-5.21, p = 8.0 x 10-15 compared to epsilon3epsilon3), but there was no interaction with vitamin D variants.	Vitamin D	244-253	apolipoprotein E	Homo sapiens	25-29
30885216-5	2019	MAIN BODY: We reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations.	Vitamin D	103-112	growth hormone 1	Homo sapiens	121-123
30885216-5	2019	MAIN BODY: We reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations.	Vitamin D	103-112	insulin like growth factor 1	Homo sapiens	124-129
30885216-6	2019	We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1.	Vitamin D	145-154	insulin like growth factor 1	Homo sapiens	171-176
31088305-12	2019	Vitamin D supplementation did not alter IL-6, TNF-alpha, IL-2 and IL-4, but reduce IFN-gamma.	Vitamin D	0-9	interferon gamma	Mus musculus	83-92
30350311-3	2019	Clinical trial results indicated that although once-daily PTH reduced calcium and vitamin D dose requirement while maintaining the normocalcemia, the regimen was not adequate to control hypercalciuria.	Vitamin D	82-91	parathyroid hormone	Homo sapiens	58-61
30880828-0	2019	Assessment of the Relationship between Serum Vitamin D and Osteocalcin Levels with Metabolic Syndrome in Non-Osteoporotic Postmenopausal Women.	Vitamin D	45-54	bone gamma-carboxyglutamate protein	Homo sapiens	59-70
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	34-43	Wnt family member 5A	Rattus norvegicus	57-62
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	244-253	Wnt family member 5A	Rattus norvegicus	57-62
30584645-9	2019	Low levels of sclerostin are associated with vitamin D deficiency and good phosphates alignment.	Vitamin D	45-54	sclerostin	Homo sapiens	14-24
30690074-1	2019	Studies to identify novel immune-regulatory functions of active vitamin D (1,25(OH)2D3) in human CD4+ T cells revealed that 1,25(OH)2D3 potently induced expression of the gene SERPINA1, encoding the anti-protease alpha-1-antitrypsin.	Vitamin D	64-73	serpin family A member 1	Homo sapiens	176-184
30690074-1	2019	Studies to identify novel immune-regulatory functions of active vitamin D (1,25(OH)2D3) in human CD4+ T cells revealed that 1,25(OH)2D3 potently induced expression of the gene SERPINA1, encoding the anti-protease alpha-1-antitrypsin.	Vitamin D	64-73	serpin family A member 1	Homo sapiens	213-232
30658160-0	2019	Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes.	Vitamin D	0-9	perilipin 2	Homo sapiens	21-32
30658160-3	2019	Therefore, we hypothesized that PLIN2 is required for vitamin D induced IMCL accumulation and increased mitochondrial oxidative function.	Vitamin D	54-63	perilipin 2	Homo sapiens	32-37
30508644-0	2019	Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen.	Vitamin D	17-26	thioredoxin interacting protein	Homo sapiens	50-55
30044347-0	2019	Hepatic Hemosiderosis Contributes to Abnormal Vitamin D-PTH Axis in Thalassemia Major.	Vitamin D	46-55	parathyroid hormone	Homo sapiens	56-59
30044347-1	2019	OBJECTIVE: The aim of this study was to evaluate the vitamin D-PTH axis in thalassemia major (TM) in relation to hepatic siderosis liver iron content.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	63-66
30044347-2	2019	DESIGN AND PARTICIPANTS: In this case-controlled observational study, vitamin D-PTH axis was studied in 158 TM and 84 age and ethnicity-matched healthy nonthalassemic controls attending University College Hospital, London.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	80-83
30508644-0	2019	Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen.	Vitamin D	17-26	mitogen-activated protein kinase 8	Homo sapiens	62-66
30399417-10	2019	However, vitamin D deficiency also resulted in more MMP12 protein in broncho-alveolar lavage and a shift in mRNA expression of MMP12/TIMP1 (p = 0.038) and MMP9/TIMP1 (p = 0.024) ratio towards more protease activity.	Vitamin D	9-18	tissue inhibitor of metalloproteinase 1	Mus musculus	133-138
30521849-0	2019	5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.	Vitamin D	70-79	arachidonate 5-lipoxygenase	Homo sapiens	0-14
30399417-10	2019	However, vitamin D deficiency also resulted in more MMP12 protein in broncho-alveolar lavage and a shift in mRNA expression of MMP12/TIMP1 (p = 0.038) and MMP9/TIMP1 (p = 0.024) ratio towards more protease activity.	Vitamin D	9-18	tissue inhibitor of metalloproteinase 1	Mus musculus	160-165
30521849-0	2019	5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.	Vitamin D	70-79	arachidonate 5-lipoxygenase	Homo sapiens	16-21
30465855-0	2019	Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-beta activity.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	94-102
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	transforming growth factor beta 1	Homo sapiens	46-54
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	transforming growth factor beta 1	Homo sapiens	211-219
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	transforming growth factor beta 1	Homo sapiens	211-219
30521849-1	2019	The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE).	Vitamin D	127-136	arachidonate 5-lipoxygenase	Homo sapiens	4-31
30521849-1	2019	The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE).	Vitamin D	127-136	arachidonate 5-lipoxygenase	Homo sapiens	33-38
30521849-1	2019	The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE).	Vitamin D	144-153	arachidonate 5-lipoxygenase	Homo sapiens	4-31
30521849-1	2019	The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE).	Vitamin D	144-153	arachidonate 5-lipoxygenase	Homo sapiens	33-38
30521849-13	2019	In conclusion, ALOX5 rs4987105 allele C confers susceptibility to T2D, lower vitamin D metabolites and higher CRP levels complement this association.	Vitamin D	77-86	arachidonate 5-lipoxygenase	Homo sapiens	15-20
30606768-10	2019	Collectively, these data show that the VDR and FBW7 are mutual cofactors, and provide a mechanistic basis for the cancer-preventive actions of vitamin D.	Vitamin D	143-152	F-box and WD repeat domain containing 7	Homo sapiens	47-51
30606768-11	2019	IMPLICATIONS: The key findings show that the VDR and the E3 ligase FBW7 regulate each other"s functions in transcriptional regulation and control of protein turnover, respectively, and provide a molecular basis for cancer-preventive actions of vitamin D.Visual Overview: http://mcr.aacrjournals.org/content/17/3/709/F1.large.jpg.	Vitamin D	244-253	F-box and WD repeat domain containing 7	Homo sapiens	67-71
31081771-7	2019	vitamin D or losartan significantly decreased TNF alpha, IL-6, RF, ESR, MDA, TC, TGs, WBCs and significantly increased RBCs, Hb, Hct, Plts and HDL.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	46-55
30645018-0	2019	Vitamin D Protects Against Alcohol-Induced Liver Cell Injury Within an NRF2-ALDH2 Feedback Loop.	Vitamin D	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
31081771-7	2019	vitamin D or losartan significantly decreased TNF alpha, IL-6, RF, ESR, MDA, TC, TGs, WBCs and significantly increased RBCs, Hb, Hct, Plts and HDL.	Vitamin D	0-9	interleukin 6	Rattus norvegicus	57-61
30946728-2	2019	Over the past several years Vitamin D has been recognized as a hormone with significant immunomodulatory effect due to the fact that it inhibits T-cell proliferation and decreases the production of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha.	Vitamin D	28-37	interleukin 2	Homo sapiens	198-211
30961684-0	2019	Vitamin D suppresses lipopolysaccharide-induced inflammatory response in vascular smooth muscle cells via inhibition of the p38 MAPK signaling pathway.	Vitamin D	0-9	mitogen-activated protein kinase 14	Homo sapiens	124-127
30946728-2	2019	Over the past several years Vitamin D has been recognized as a hormone with significant immunomodulatory effect due to the fact that it inhibits T-cell proliferation and decreases the production of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha.	Vitamin D	28-37	interferon gamma	Homo sapiens	213-262
30941358-16	2019	In 7 patients that completed the treatment period, there was an association between elevated serum levels of IL-6, IL-1beta, TNF-alpha, CRP, and LPL and also the reduced serum levels of albumin, prealbumin, Zn, vitamin D, and GPS, respectively.	Vitamin D	211-220	interleukin 6	Homo sapiens	109-113
30813930-8	2019	RESULTS: As a critical regulator, vitamin D suppresses LPS-induced HIF-1alpha to block IFNgamma and IL-1beta productions.	Vitamin D	34-43	interleukin 1 beta	Homo sapiens	100-108
30811465-1	2019	INTRODUCTION: Cathelicidin (also known as LL-37 in humans) is an antimicrobial peptide secreted by epithelial and immune cells and regulated by vitamin D.	Vitamin D	144-153	cathelicidin antimicrobial peptide	Homo sapiens	42-47
30796319-8	2019	Increasing vitamin D upon TNFalpha-blockade paralleled RA clinical improvement (r = -0.610, p = 0.027) and DHCR7 elevation (r = 0.766, p = 0.002).	Vitamin D	11-20	tumor necrosis factor	Homo sapiens	26-34
30837950-2	2019	Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of type 2 diabetes (T2DM).	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	34-37
30837950-7	2019	This is important in clinical conditions where the amount of DBP is affected, and has caused a renewed interest in which vitamin D metabolite to measure in clinical situations.	Vitamin D	121-130	D-box binding PAR bZIP transcription factor	Homo sapiens	61-64
30778159-9	2019	Although 1,25(OH)2D and 24,25(OH)2D are decreased in CKD patient serum, our findings suggest that PTH and FGF23 retain their effects to regulate vitamin D metabolism even in the kidneys of these patients, while production of 1,25(OH)2D and 24,25(OH)2D from 25(OH)D is restricted due to either impairment of megalin-mediated reabsorption of the 25(OH)D-DBP complex or reduced renal mass.	Vitamin D	145-154	parathyroid hormone	Homo sapiens	98-101
30788611-0	2019	Vitamin D cutoff point in relation to parathyroid hormone: a population based study in Riyadh city, Saudi Arabia.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	38-57
30777056-7	2019	Examination of the DNA sequences of CYP2R1 and CYP27B1 genes, which are genes linked with vitamin D metabolism, showed a CYP2R1 frameshift mutation in exon 5 (where T is deleted at position c.1386).	Vitamin D	90-99	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	47-54
30287151-5	2019	Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES).	Vitamin D	129-138	nuclear factor kappa B subunit 1	Homo sapiens	268-290
30287151-5	2019	Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES).	Vitamin D	129-138	nuclear factor kappa B subunit 1	Homo sapiens	292-301
30760247-3	2019	Vitamin D induces IL-1beta, which plays an important role in terms of resistance to TB.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	18-26
30216432-9	2019	In addition, simvastatin increased transcription of the vitamin D-activating enzyme CYP27B1 which, in turn, may activate LL-37/hCAP-18 production.	Vitamin D	56-65	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	84-91
30216432-9	2019	In addition, simvastatin increased transcription of the vitamin D-activating enzyme CYP27B1 which, in turn, may activate LL-37/hCAP-18 production.	Vitamin D	56-65	cathelicidin antimicrobial peptide	Homo sapiens	121-126
30216432-9	2019	In addition, simvastatin increased transcription of the vitamin D-activating enzyme CYP27B1 which, in turn, may activate LL-37/hCAP-18 production.	Vitamin D	56-65	cathelicidin antimicrobial peptide	Homo sapiens	127-134
30583032-0	2019	Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes?	Vitamin D	15-24	insulin	Homo sapiens	48-55
30583032-2	2019	AIMS: The aim of this study is to evaluate the effect of high-dose vitamin D on insulin sensitivity and the risk of progression to diabetes.	Vitamin D	67-76	insulin	Homo sapiens	80-87
30583032-10	2019	CONCLUSIONS: In patients with pre-diabetes and hypovitaminosis D, high dose vitamin D improves insulin sensitivity and decreases risk of progression toward diabetes.	Vitamin D	76-85	insulin	Homo sapiens	95-102
30578920-0	2019	Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice.	Vitamin D	34-43	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	65-72
30222077-0	2019	ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux.	Vitamin D	33-42	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	0-5
30222077-2	2019	Thus, we investigated the involvement of ATP binding cassette subfamily B member 1 (ABCB1) in vitamin D intestinal efflux.	Vitamin D	94-103	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	41-82
30222077-2	2019	Thus, we investigated the involvement of ATP binding cassette subfamily B member 1 (ABCB1) in vitamin D intestinal efflux.	Vitamin D	94-103	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	84-89
30357820-7	2019	However, co-addition of TLR2/1L and IFN-gamma re-educated M2 MPhi towards the M1 MPhi phenotype, with a decrease in the phagocytosis of lipids and mycobacteria, as well as recovery of the vitamin-D-dependent antimicrobial pathway compared with M2 MPhi maintained in polarizing conditions.	Vitamin D	188-197	toll like receptor 2	Homo sapiens	24-31
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	225-234	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	143-150
28825325-0	2019	Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats.	Vitamin D	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	60-64
30594355-8	2019	Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status.	Vitamin D	54-63	sterol 26-hydroxylase, mitochondrial	Bos taurus	80-87
30594355-8	2019	Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status.	Vitamin D	54-63	D-box binding PAR bZIP transcription factor	Bos taurus	125-128
30465456-9	2019	CONCLUSION: In patients with temporomandibular disorders, increased parathyroid hormone levels in response to vitamin D deficiency was significantly more prominent.	Vitamin D	110-119	parathyroid hormone	Homo sapiens	68-87
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	84-93	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	143-150
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	84-93	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	84-93	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	163-170
30359690-2	2019	In human placentas, testosterone lowers the expression of CYP27B1, the vitamin D (VD)-activating enzyme, diminishing cathelicidin synthesis, a potent VD-dependent antimicrobial peptide (AMP).	Vitamin D	71-80	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	58-65
30658483-9	2019	This study supports beneficial effects of vitamin D supplementation on liver markers and modest improvements in insulin sensitivity in vitamin D deficient women with PCOS.	Vitamin D	135-144	insulin	Homo sapiens	112-119
30285234-0	2019	The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to vitamin D.	Vitamin D	136-145	zinc finger MIZ-type containing 1	Homo sapiens	53-58
30285234-4	2019	We show these genes are responsive to vitamin D: ZMIZ1 expression increased and IRF8 expression decreased, and this response was affected by genotype in different cell subsets.	Vitamin D	38-47	zinc finger MIZ-type containing 1	Homo sapiens	49-54
30285234-6	2019	These data indicate that vitamin D regulation of ZMIZ1 and IRF8 in DCs and monocytes contribute to latitude-dependent autoimmune disease risk.	Vitamin D	25-34	zinc finger MIZ-type containing 1	Homo sapiens	49-54
30820485-11	2019	Maternal laboratory findings indicated normocalcemia, but vitamin D deficiency with a high PTH level for the lactation period was observed.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	91-94
32036848-8	2019	PTH levels, however, proved erratic and showed an upward trend over the first year of therapy; however its levels partially decreased following increase of vitamin D levels by replacement therapy.	Vitamin D	156-165	parathyroid hormone	Homo sapiens	0-3
31023051-9	2019	CONCLUSION: Our results showed that vitamin D deficiency predisposed to the development of sepsis, negatively correlated with CRP, presepsin, sTREM-1 and SOFA score and their levels associates with both 7th and 28th days survival of patients (Tab.	Vitamin D	36-45	C-reactive protein	Homo sapiens	126-129
30648528-9	2019	This review summarizes the role of vitamin D in the regulation of glucose homeostasis with an emphasis on insulin resistance, blood pressure, dyslipidaemia, endothelial dysfunction and related cardiovascular diseases and also underline the plausible mechanisms for all the documented effects.	Vitamin D	35-44	insulin	Homo sapiens	106-113
30679399-4	2019	Prescription of active vitamin D or its analogues is associated with lower rates of cardiovascular events in predialysis and dialysis patients, however indication biases often seen in observational studies cannot preclude the possibility that the benefit of these agents is limited to patients with high parathyroid hormone(PTH)levels.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	324-327
30246883-7	2019	RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	130-133
30246883-9	2019	Between the groups, there were significant decrease in weight, fat mass, serum MCP-1 and PTH concentrations and significant increase in serum 25OHD concentrations after intervention with vitamin D supplementation compared to placebo (P < 0.05).	Vitamin D	187-196	parathyroid hormone	Homo sapiens	89-92
30387399-7	2019	Vitamin D level was compared between patients with and without insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	63-70
31109269-7	2019	RESULTS: Vitamin D deficiency is associated with disease activity, quality of life, the consumption of social and healthcare resources, and the durability of anti-TNFalpha biological treatment.	Vitamin D	9-18	tumor necrosis factor	Homo sapiens	163-171
30740162-2	2019	The active form of vitamin D is known to inhibit the proliferation of keloid fibroblasts by inhibiting extracellular matrix production induced by transforming growth factor ss (TGF-beta) and increasing matrix metalloproteinase (MMP) activity.	Vitamin D	19-28	transforming growth factor beta 1	Homo sapiens	177-185
31149066-2	2019	Objective: In this study, we investigated the relationship between NLR-PLR and parathyroid hormone (PTH) and vitamin D in patients with high PTH levels.	Vitamin D	109-118	parathyroid hormone	Homo sapiens	79-98
30550771-0	2019	Modulation of vitamin D signaling by the pioneer factor CEBPA.	Vitamin D	14-23	CCAAT enhancer binding protein alpha	Homo sapiens	56-61
30550771-4	2019	Transcriptome-wide analysis after CEBPA silencing indicated that the pioneer factor enhances both the basal expression and ligand inducibility of 70 vitamin D target genes largely involved in lipid signaling and metabolism.	Vitamin D	149-158	CCAAT enhancer binding protein alpha	Homo sapiens	34-39
30550771-5	2019	In contrast, CEBPA suppresses 82 vitamin D target genes many of which are related to the modulation of T cell activity by monocytes.	Vitamin D	33-42	CCAAT enhancer binding protein alpha	Homo sapiens	13-18
30550771-7	2019	Moreover, prominent occupancy of the myeloid pioneer factor PU.1 on 1,25(OH)2D3-sensitive CEBPA enhancers mechanistically explains the dichotomy of vitamin D target genes.	Vitamin D	148-157	CCAAT enhancer binding protein alpha	Homo sapiens	90-95
30550771-8	2019	In conclusion, CEBPA supports vitamin D signaling concerning actions of the innate immune system, but uses the antagonism with PU.1 for suppressing possible overreactions of adaptive immunity.	Vitamin D	30-39	CCAAT enhancer binding protein alpha	Homo sapiens	15-20
30588902-10	2019	Vitamin D-sufficient women at baseline had higher increases in insulin and adiponectin changes throughout gestation than those who were insufficient.	Vitamin D	0-9	insulin	Homo sapiens	63-70
30588902-10	2019	Vitamin D-sufficient women at baseline had higher increases in insulin and adiponectin changes throughout gestation than those who were insufficient.	Vitamin D	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	75-86
30387399-3	2019	This study was assigned to evaluate relation between serum vitamin D level and insulin resistance in gestational diabetes mellitus(GDM).	Vitamin D	59-68	insulin	Homo sapiens	79-86
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	225-234	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158
31210105-8	2019	CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-gamma, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes.	Vitamin D	80-89	peroxisome proliferator activated receptor gamma	Homo sapiens	164-174
31210105-8	2019	CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-gamma, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes.	Vitamin D	80-89	AKT serine/threonine kinase 1	Homo sapiens	176-179
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	225-234	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	163-170
31210105-8	2019	CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-gamma, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes.	Vitamin D	80-89	proline rich transmembrane protein 2	Homo sapiens	260-263
30321667-9	2019	Vitamin D group participants demonstrated significant improvements in waist-hip ratio (-0.02 +- 0.03 vs 0.00 +- 0.02; P &lt; 0.01) and fasting blood glucose (-0.1 +- 0.2 vs 0.2 +- 04 mmol/L; P &lt; 0.04) compared with the placebo group, but changes in insulin sensitivity and other body composition measures did not differ significantly between groups (all P &gt; 0.05).	Vitamin D	0-9	insulin	Homo sapiens	252-259
31389312-5	2019	In recent years, both clinical trials and animal experiments have shown that vitamin D plays a regulatory role in decreasing blood pressure (BP) through inhibiting renin- angiotensin-aldosterone system activity, modulating function of vascular wall and reducing vascular oxidative stress.	Vitamin D	77-86	renin	Homo sapiens	164-169
31333117-2	2019	Thus, vitamin D insufficiency has been linked to cardiometabolic risk factors including obesity, insulin resistance, hypertension, dyslipidemia, as well as type 2 diabetes and cardiovascular disease.	Vitamin D	6-15	insulin	Homo sapiens	97-104
30854952-0	2019	The Effects of Vitamin D Supplementation on Glycemic Control, Lipid Profiles and C-Reactive Protein Among Patients with Cardiovascular Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.	Vitamin D	15-24	C-reactive protein	Homo sapiens	81-99
30854952-3	2019	This systematic review and meta-analysis aimed to determine the effects of vitamin D supplementation on glycemic control, lipid profiles, and C-reactive protein among patients with coronary artery disease.	Vitamin D	75-84	C-reactive protein	Homo sapiens	142-160
30854952-10	2019	Additionally, vitamin D supplementation significantly reduced C-reactive protein (CRP) levels (WMD: -0.75; 95% CI: -1.28, -0.23).	Vitamin D	14-23	C-reactive protein	Homo sapiens	62-80
30854952-10	2019	Additionally, vitamin D supplementation significantly reduced C-reactive protein (CRP) levels (WMD: -0.75; 95% CI: -1.28, -0.23).	Vitamin D	14-23	C-reactive protein	Homo sapiens	82-85
30854952-11	2019	CONCLUSION: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation on improving glycemic control, HDL-cholesterol and CRP levels among patients with CVD, though it did not affect triglycerides, total- and LDL-cholesterol levels.	Vitamin D	70-79	C-reactive protein	Homo sapiens	147-150
31405646-11	2019	In term of metabolic profiles, mean change in level of Hemoglobin A1c (HbA1c), insulin and triglycerides (TG) were significantly higher in response to the treatment with vitamin D compared to placebo (p-value &lt;0.02).	Vitamin D	170-179	insulin	Homo sapiens	79-86
31235107-8	2019	Serum vitamin D showed significant negative correlations with HbA1c (r = - 0.186, P = 0.046), ALT (r = - 192, P = 0.040) and AST (r = - 0.188, P = 0.044) whereas significant positive correlations were found with HDL-C (r = 0.188, P = 0.044) and calcium (r = 0.239, P = 0.010).	Vitamin D	6-15	solute carrier family 17 member 5	Homo sapiens	125-128
31425941-0	2019	Does vitamin D status correlate with insulin resistance in obese prediabetic patients?	Vitamin D	5-14	insulin	Homo sapiens	37-44
31425941-7	2019	Also, A significant inverse correlation was observed between vitamin D levels &amp; body mass index(r = - 0.28, P = 0.004); fasting blood sugar (r = - 0.22, P = 0.002); HOMA insulin resistance (r = - 0.25 P = 0.01); HbA1C (r = - 0.2, P= 0.004).	Vitamin D	61-70	insulin	Homo sapiens	174-181
31336513-7	2019	Among patients with GDM, vitamin D was found to correlate negatively with HbA1c (p &lt; 0.001), insulin(p = 0.019) and HOMA-IR(p = 0.034).	Vitamin D	25-34	insulin	Homo sapiens	96-103
31930870-12	2019	CONCLUSION: A significant interaction of vitamin D deficiency and high PTH on postural stability is detected among healthy adult males.	Vitamin D	41-50	parathyroid hormone	Homo sapiens	71-74
30641712-11	2019	CONCLUSIONS: It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-alpha and IL-6.	Vitamin D	31-40	tumor necrosis factor	Homo sapiens	212-221
30641712-11	2019	CONCLUSIONS: It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-alpha and IL-6.	Vitamin D	31-40	interleukin 6	Homo sapiens	226-230
30289192-12	2019	DISCUSSION: This study is the first study which showed a correlation between TST negativity and increased PTH levels and receiving vitamin D treatment.	Vitamin D	131-140	parathyroid hormone	Homo sapiens	106-109
30879014-0	2019	Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-gamma/HO-1 Pathway.	Vitamin D	0-9	angiotensinogen	Homo sapiens	22-36
30879014-0	2019	Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-gamma/HO-1 Pathway.	Vitamin D	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	94-104
30879014-4	2019	There is evidence showing that vitamin D can reverse the effects of AngII, but the molecular mechanisms by which this occurs are not known.	Vitamin D	31-40	angiotensinogen	Homo sapiens	68-73
30879014-5	2019	Our results demonstrate that vitamin D improved the viability, migration ability, and tube formation of AngII-pretreated endothelial progenitor cells (EPCs) and inhibited the apoptosis of EPCs induced by AngII.	Vitamin D	29-38	angiotensinogen	Homo sapiens	104-109
30879014-5	2019	Our results demonstrate that vitamin D improved the viability, migration ability, and tube formation of AngII-pretreated endothelial progenitor cells (EPCs) and inhibited the apoptosis of EPCs induced by AngII.	Vitamin D	29-38	angiotensinogen	Homo sapiens	204-209
30879014-6	2019	Vitamin D also reversed reactive oxygen species production, vascular inflammatory cytokine generation, and nuclear factor kappa-B activation in EPCs induced by AngII.	Vitamin D	0-9	angiotensinogen	Homo sapiens	160-165
30879014-7	2019	Furthermore, EPC pretreatment with GW9662 (the antagonist for PPAR-gamma) or siHO-1 decreased the protective effect of vitamin D on AngII-induced EPC injury.	Vitamin D	119-128	peroxisome proliferator activated receptor gamma	Homo sapiens	62-72
30879014-7	2019	Furthermore, EPC pretreatment with GW9662 (the antagonist for PPAR-gamma) or siHO-1 decreased the protective effect of vitamin D on AngII-induced EPC injury.	Vitamin D	119-128	angiotensinogen	Homo sapiens	132-137
30879014-8	2019	Overall, our data indicate that vitamin D ameliorated AngII-induced abnormal EPC injury by decreasing oxidative stress and inflammatory cytokine levels.	Vitamin D	32-41	angiotensinogen	Homo sapiens	54-59
30879014-9	2019	These findings also suggest that vitamin D protected EPCs from AngII-induced vascular injury via the activation of the PPAR-gamma/HO-1 signaling pathway.	Vitamin D	33-42	angiotensinogen	Homo sapiens	63-68
30879014-9	2019	These findings also suggest that vitamin D protected EPCs from AngII-induced vascular injury via the activation of the PPAR-gamma/HO-1 signaling pathway.	Vitamin D	33-42	peroxisome proliferator activated receptor gamma	Homo sapiens	119-129
30959383-0	2019	Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms.	Vitamin D	12-21	D-box binding PAR bZIP transcription factor	Homo sapiens	59-76
30959383-1	2019	OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.	Vitamin D	68-77	D-box binding PAR bZIP transcription factor	Homo sapiens	95-98
30959383-1	2019	OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.	Vitamin D	122-131	D-box binding PAR bZIP transcription factor	Homo sapiens	95-98
30959383-10	2019	CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults.	Vitamin D	133-142	D-box binding PAR bZIP transcription factor	Homo sapiens	47-50
31235092-3	2019	Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR).	Vitamin D	0-9	insulin	Homo sapiens	69-76
31235092-9	2019	(15.5 +- 7.46 vs 24.4 +- 8.19 and 22.86 +- 9.58 ng/ml respectively) also Total vitamin D level is negatively correlated with age, weight, BMI, WC, total cholesterol, LDL, TG, FPG, HbA1c and FLI.	Vitamin D	79-88	FLII actin remodeling protein	Homo sapiens	190-193
30514196-14	2019	There were significant negative correlations in group I between serum S100-B and PH and between S100-B and serum vitamin D before and after therapy.	Vitamin D	113-122	S100 calcium binding protein B	Homo sapiens	96-102
30514196-15	2019	CONCLUSION: Vitamin D was found to improve the cases of group I as demonstrated by the reduction of serum S100-B levels after vitamin D therapy.	Vitamin D	12-21	S100 calcium binding protein B	Homo sapiens	106-112
30651833-8	2019	Paricalcitol, cinacalcet plus vitamin D analogue and cinacalcet were significantly more efficacious in controlling PTH levels compared with conventional therapy (which comprises calcium-based phosphate binders, non-calcium-based phosphate binders and vitamin D analogues) [odds ratio (OR)=3.99, 2.91 and 2.47, respectively] and placebo (OR=20.32, 14.89 and 12.56, respectively).	Vitamin D	30-39	parathyroid hormone	Homo sapiens	115-118
31496578-1	2019	Vitamin D-dependent rickets (VDDR) is a disorder of bone development characterized by softened weak bones.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-33
31666475-0	2019	Poor Vitamin D Status in Active Pulmonary Tuberculosis Patients and Its Correlation with Leptin and TNF-alpha.	Vitamin D	5-14	tumor necrosis factor	Homo sapiens	100-109
30044963-1	2019	The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, comprises more than 500 genes, half of which are primary targets.	Vitamin D	4-13	GLI family zinc finger 2	Homo sapiens	80-85
30071248-1	2019	AIM: Vitamin D deficiency in rodents negatively affects glucose-stimulated insulin secretion (GSIS) and human epidemiological studies connect poor vitamin D status with type 2 diabetes.	Vitamin D	5-14	insulin	Homo sapiens	75-82
30358420-7	2019	By increasing the level of cell cycle inhibitory and promoting proteins p21 and CDK1, vitamin D theoretically has both preventive and promoting effects on pancreatic cell division.	Vitamin D	86-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	72-75
32270970-2	2019	Vitamin D metabolites affect insulin sensitivity of cells.	Vitamin D	0-9	insulin	Homo sapiens	29-36
31586507-7	2019	Very low level of vitamin D that disrupted calcium absorption through the intestine, and decreased calcemia increased parathyroid hormone levels with resulting bone effect.	Vitamin D	18-27	parathyroid hormone	Homo sapiens	118-137
32105004-0	2019	The effect of 2000 iu/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents.	Vitamin D	26-35	insulin	Homo sapiens	55-62
32105004-2	2019	The effect of 2000 iu/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents.	Vitamin D	26-35	insulin	Homo sapiens	55-62
32105004-4	2019	The aim of this study was to determine the vitamin D deficiency prevalence in obese adolescents and to investigate the effect of vitamin D supplementation on insulin resistance and cardiovascular risk parameters in obese adolescents with vitamin D deficiency.	Vitamin D	129-138	insulin	Homo sapiens	158-165
32105004-4	2019	The aim of this study was to determine the vitamin D deficiency prevalence in obese adolescents and to investigate the effect of vitamin D supplementation on insulin resistance and cardiovascular risk parameters in obese adolescents with vitamin D deficiency.	Vitamin D	129-138	insulin	Homo sapiens	158-165
32105004-8	2019	The only difference between the two groups was PTH level which was higher in the vitamin D deficiency group.	Vitamin D	81-90	parathyroid hormone	Homo sapiens	47-50
32105004-12	2019	Vitamin D reduced interleukin-6 levels by its antiinflammatory effect.	Vitamin D	0-9	interleukin 6	Homo sapiens	18-31
30557404-3	2018	In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0.28); p21 expression alone and relative to mib-1 expression increased 29% (P = 0.06) and 73% (P = 0.06), respectively; and bax expression relative to mib-1 expression increased 58% (P = 0.21).	Vitamin D	7-16	BCL2 associated X, apoptosis regulator	Homo sapiens	274-277
30557404-6	2018	These pilot study results support further investigation of whether 1) vitamin D and calcium promote colorectal epithelial cell differentiation, reduce proliferation, and promote apoptosis in the normal-appearing human colorectal mucosa, 2) vitamin D and calcium act as chemopreventive agents against colorectal neoplasms, and 3) mib-1, p21, and bax are potential "treatable", pre-neoplastic, biomarkers of risk for colorectal neoplasms.	Vitamin D	240-249	BCL2 associated X, apoptosis regulator	Homo sapiens	345-348
30627160-6	2018	Vitamin D supplementation significantly reduced fasting glucose by 0.11 mmol/L, fasting insulin by 1.47 mIU/L, and HOMA-IR by 0.32 while increasing total 25 (OH) D levels by 40.14 nmol/L.	Vitamin D	0-9	insulin	Homo sapiens	88-95
30248338-4	2018	The mRNA levels of hepatic VDR- and vitamin D-related genes [cytochrome P450 (CYP) 2R1, CYP27A1, and CYP3A4] were higher in NAFL patients compared with normal liver subjects.	Vitamin D	36-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
29980378-0	2018	Serum Vitamin D and Its Upregulated Protein, Thioredoxin Interacting Protein, Are Associated With Beta-Cell Dysfunction in Adult Patients With Type 1 and Type 2 Diabetes.	Vitamin D	6-15	thioredoxin interacting protein	Homo sapiens	45-76
29308676-4	2018	Vitamin D caused more reduction in monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGFbeta-1), and renin-angiotensin levels that gave better kidney function compared to the DM + L group.	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	107-116
29153269-14	2018	CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China.	Vitamin D	32-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	55-61
31313545-3	2018	Vitamin D has found to be deficient in diabetic patient and it"s role in insulin regulation.	Vitamin D	0-9	insulin	Homo sapiens	73-80
30593197-11	2018	In conclusion, Vit D deficiency was more common in women, and associated with poorer musculoskeletal health and higher cardiovascular and metabolic risk, including higher BMI, DBP, insulin resistance, total cholesterol, and triglyceride.	Vitamin D	15-20	D-box binding PAR bZIP transcription factor	Homo sapiens	176-179
30593197-11	2018	In conclusion, Vit D deficiency was more common in women, and associated with poorer musculoskeletal health and higher cardiovascular and metabolic risk, including higher BMI, DBP, insulin resistance, total cholesterol, and triglyceride.	Vitamin D	15-20	insulin	Homo sapiens	181-188
30280198-1	2018	Cytochrome P450 family 4 (CYP4) enzymes are known as microsomal omega (omega)-hydroxylases that metabolize fatty acids, eicosanoids, vitamin D and carcinogens.	Vitamin D	133-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-24
30280198-1	2018	Cytochrome P450 family 4 (CYP4) enzymes are known as microsomal omega (omega)-hydroxylases that metabolize fatty acids, eicosanoids, vitamin D and carcinogens.	Vitamin D	133-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-30
29481636-8	2018	Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients.	Vitamin D	44-53	sclerostin	Homo sapiens	17-27
29481636-11	2018	Conclusions: Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.	Vitamin D	13-22	sclerostin	Homo sapiens	61-71
30519274-6	2018	Vitamin D supplementation significantly decreased von willebrand factor (vWF) (SMD -0.27; 95% CI, - 0.46, - 0.08; P = 0.006; I2:40.5%).	Vitamin D	0-9	von Willebrand factor	Homo sapiens	73-76
30519274-8	2018	The pooled data from trials of vitamin D supplementation with dosage of &lt;=4000 IU/day (- 0.37, 95% CI: -0.65, - 0.10, I2: 73.5%) significantly reduced vWF concentrations, while there was no effect of vitamin D supplementation on vWF concentrations among trials with the dosage of intervention &gt; 4000 IU/day (- 0.17, 95% CI: -0.43, 0.10, I2: 0.0%).	Vitamin D	31-40	von Willebrand factor	Homo sapiens	154-157
30519274-8	2018	The pooled data from trials of vitamin D supplementation with dosage of &lt;=4000 IU/day (- 0.37, 95% CI: -0.65, - 0.10, I2: 73.5%) significantly reduced vWF concentrations, while there was no effect of vitamin D supplementation on vWF concentrations among trials with the dosage of intervention &gt; 4000 IU/day (- 0.17, 95% CI: -0.43, 0.10, I2: 0.0%).	Vitamin D	31-40	von Willebrand factor	Homo sapiens	232-235
30519274-8	2018	The pooled data from trials of vitamin D supplementation with dosage of &lt;=4000 IU/day (- 0.37, 95% CI: -0.65, - 0.10, I2: 73.5%) significantly reduced vWF concentrations, while there was no effect of vitamin D supplementation on vWF concentrations among trials with the dosage of intervention &gt; 4000 IU/day (- 0.17, 95% CI: -0.43, 0.10, I2: 0.0%).	Vitamin D	203-212	von Willebrand factor	Homo sapiens	154-157
30519274-11	2018	Conclusions: Overall, the current meta-analysis demonstrated that vitamin D supplementation to patients with metabolic syndrome and related disorders resulted in an improvement in vWF, but did not affect ICAM-1, VCAM-1, E-selectin and endothelin levels.	Vitamin D	66-75	von Willebrand factor	Homo sapiens	180-183
30453584-4	2018	The mRNA levels of TG2 and TNF-alpha were higher in PBMC of subjects having hypovitaminosis D, namely plasma 25(OH)vitamin D3 levels lower than 50 nmol/L, than in those with normal vitamin D levels.	Vitamin D	115-124	transglutaminase 2	Homo sapiens	19-22
30453584-4	2018	The mRNA levels of TG2 and TNF-alpha were higher in PBMC of subjects having hypovitaminosis D, namely plasma 25(OH)vitamin D3 levels lower than 50 nmol/L, than in those with normal vitamin D levels.	Vitamin D	115-124	tumor necrosis factor	Homo sapiens	27-36
30453584-5	2018	Moreover, NF-kappaB up-regulation and nuclear translocation were detected, concomitantly with TG2 as well as TNF-alpha increased expression, in PBMC of vitamin D-deficient subjects.	Vitamin D	152-161	nuclear factor kappa B subunit 1	Homo sapiens	10-19
30453584-5	2018	Moreover, NF-kappaB up-regulation and nuclear translocation were detected, concomitantly with TG2 as well as TNF-alpha increased expression, in PBMC of vitamin D-deficient subjects.	Vitamin D	152-161	transglutaminase 2	Homo sapiens	94-97
30453584-5	2018	Moreover, NF-kappaB up-regulation and nuclear translocation were detected, concomitantly with TG2 as well as TNF-alpha increased expression, in PBMC of vitamin D-deficient subjects.	Vitamin D	152-161	tumor necrosis factor	Homo sapiens	109-118
30400797-10	2018	Vitamin D analog calcipotriol blocked POSTN secretion from activated HSCs.	Vitamin D	0-9	periostin, osteoblast specific factor	Mus musculus	38-43
30257400-8	2018	Also, interleukin 6 and tumor necrosis factor alpha showed an enhancement due to dietary restriction of vitamin D.	Vitamin D	104-113	interleukin 6	Mus musculus	6-51
29846166-1	2018	OBJECTIVES: To determine and compare the prevalence of vitamin D deficiency in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).	Vitamin D	55-64	CTD	Homo sapiens	157-160
29846166-8	2018	RESULTS: Serum vitamin D levels were significantly lower in CTD-ILD patients (p&lt;0.0001).	Vitamin D	15-24	CTD	Homo sapiens	60-63
29846166-9	2018	Vitamin D deficiency was lower in the CTD-ILD group (mean+-SD: 11.5+-4.1 ng/ml) than in the control group (13.9+-4.8 ng/ml, p=0.004).	Vitamin D	0-9	CTD	Homo sapiens	38-41
29846166-12	2018	When the odds ratio was adjusted for CTD-ILD, vitamin D deficiency was also a risk factor for CTD-ILD, whereas serum levels of calcium was a protective factor for CTD-ILD.	Vitamin D	46-55	CTD	Homo sapiens	94-97
29846166-12	2018	When the odds ratio was adjusted for CTD-ILD, vitamin D deficiency was also a risk factor for CTD-ILD, whereas serum levels of calcium was a protective factor for CTD-ILD.	Vitamin D	46-55	CTD	Homo sapiens	94-97
29846166-13	2018	CONCLUSIONS: Serum vitamin D deficiency is associated with CTD-ILD and is a risk factor.	Vitamin D	19-28	CTD	Homo sapiens	59-62
29846166-14	2018	Therefore, vitamin D may play a role in the pathogenesis of CTD-ILD.	Vitamin D	11-20	CTD	Homo sapiens	60-63
28783999-7	2018	IL-2, Ig-A, and Ig-G levels are significant increased in the vitamin D supplementation group compared with the control group (p &lt; .05) (3).	Vitamin D	61-70	interleukin 2	Homo sapiens	0-4
29900589-9	2018	This is also the case when treating low PTH levels by decreasing vitamin D or calcium load.	Vitamin D	65-74	parathyroid hormone	Homo sapiens	40-43
30058600-7	2018	Lower concentrations of TNF-alpha was a predictor of lower levels of vitamin D.	Vitamin D	69-78	tumor necrosis factor	Homo sapiens	24-33
30205014-0	2018	Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-beta1 expression in hepatocellular carcinoma-induced in rats.	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	89-98
30205014-6	2018	Treatment with 5-FU + Vit D significantly decreased gene expression of nuclear factor erythroid 2-related factor 2 (NrF2) and transforming growth factor beta1 (TGF-beta1) at both the gene and protein level and serum AFP concentrations in comparison with their corresponding monotherapy.	Vitamin D	22-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-114
30205014-6	2018	Treatment with 5-FU + Vit D significantly decreased gene expression of nuclear factor erythroid 2-related factor 2 (NrF2) and transforming growth factor beta1 (TGF-beta1) at both the gene and protein level and serum AFP concentrations in comparison with their corresponding monotherapy.	Vitamin D	22-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	116-120
30205014-6	2018	Treatment with 5-FU + Vit D significantly decreased gene expression of nuclear factor erythroid 2-related factor 2 (NrF2) and transforming growth factor beta1 (TGF-beta1) at both the gene and protein level and serum AFP concentrations in comparison with their corresponding monotherapy.	Vitamin D	22-27	transforming growth factor, beta 1	Rattus norvegicus	126-158
30205014-6	2018	Treatment with 5-FU + Vit D significantly decreased gene expression of nuclear factor erythroid 2-related factor 2 (NrF2) and transforming growth factor beta1 (TGF-beta1) at both the gene and protein level and serum AFP concentrations in comparison with their corresponding monotherapy.	Vitamin D	22-27	transforming growth factor, beta 1	Rattus norvegicus	160-169
30205014-9	2018	Combination therapy in a TAA-induced HCC rat model was more effective than 5-FU or Vit D through the modulation of TGF-beta1, caspase-3, and NrF2 expressions.	Vitamin D	83-88	transforming growth factor, beta 1	Rattus norvegicus	115-124
30205014-9	2018	Combination therapy in a TAA-induced HCC rat model was more effective than 5-FU or Vit D through the modulation of TGF-beta1, caspase-3, and NrF2 expressions.	Vitamin D	83-88	NFE2 like bZIP transcription factor 2	Rattus norvegicus	141-145
30345478-2	2018	OBJECTIVES: The aim of this cross-sectional observational study in somatic and psychogeriatric nursing home residents was to determine the efficacy of a standardized oral vitamin D dosing regimen (VDDR) consisting of a loading dose (LD) of cholecalciferol 200,000 IU followed by a maintenance dose (MD) of 100,000 IU every 13 weeks in obtaining and maintaining an adequate and safe vitamin D trough level (VDTL), defined as 75-220 nmol/L (reference range).	Vitamin D	171-180	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	197-201
30390810-1	2018	Parathyroid hormone (PTH) is the major secretory product of the parathyroid glands, and in hypocalcemic conditions, can enhance renal calcium reabsorption, increase active vitamin D production to increase intestinal calcium absorption, and mobilize calcium from bone by increasing turnover, mainly but not exclusively in cortical bone.	Vitamin D	172-181	parathyroid hormone	Homo sapiens	0-19
30390810-1	2018	Parathyroid hormone (PTH) is the major secretory product of the parathyroid glands, and in hypocalcemic conditions, can enhance renal calcium reabsorption, increase active vitamin D production to increase intestinal calcium absorption, and mobilize calcium from bone by increasing turnover, mainly but not exclusively in cortical bone.	Vitamin D	172-181	parathyroid hormone	Homo sapiens	21-24
30390818-2	2018	Impaired QOL in patients treated with conventional therapy with calcium and active vitamin D has been documented in epidemiologic (registry) studies, case-controlled studies, and surveys, and at baseline in clinical trials of parathyroid hormone (PTH).	Vitamin D	83-92	parathyroid hormone	Homo sapiens	226-245
30172894-0	2018	Vitamin D partially reverses the increase in p-NF-kappaB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats.	Vitamin D	0-9	synaptotagmin 1	Rattus norvegicus	57-60
30172894-0	2018	Vitamin D partially reverses the increase in p-NF-kappaB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats.	Vitamin D	0-9	interleukin 6	Rattus norvegicus	79-92
31089567-4	2018	Low serum vitamin D has been found to be associated with various types of metabolic illness such as obesity, diabetes mellitus, insulin resistance, cardiovascular diseases including hypertension.	Vitamin D	10-19	insulin	Homo sapiens	128-135
30515164-0	2018	Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D.	Vitamin D	181-190	toll like receptor 7	Homo sapiens	28-32
30453584-6	2018	The present findings confirm that an increase in TG2 expression exacerbates the activation of NF-kappaB and the production of pro-inflammatory cytokines, and suggest a link between vitamin D deficiency, TG2 up-regulation, and inflammation.	Vitamin D	181-190	transglutaminase 2	Homo sapiens	49-52
30613518-13	2018	Conclusion: Given the role of this vitamin in secretion and the effect of insulin, it seems useful to monitor the serum level of vitamin D in a diabetic patient and prescribe its supplements if necessary.	Vitamin D	129-138	insulin	Homo sapiens	74-81
30008129-9	2018	In the overall cohort, the odds of being anemic was 1.9 times higher (95% CI, 1.22-3.04, p &lt; 0.01) in vitamin D insufficient/deficient vs sufficient children, when adjusting for covariates (age, sex, race [black, white, or other], body mass index (BMI), iohexol GFR (iGFR), erythropoietin stimulation agent (ESA) use, iron supplementation use, and underlying cause of CKD).	Vitamin D	105-114	erythropoietin	Homo sapiens	277-291
30326825-7	2018	Vitamin D signaling pathway activation was evaluated by measuring the expression levels of VDR, CYP24A1, Tumor necrosis factor alpha (TNFalpha) and cathelicidin (CAMP) by qRT-PCR.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	105-132
30588186-6	2018	Our results show that melatonin and vitamin D are able to modulate ADSCs commitment towards osteogenic phenotype through the upregulation of HDAC1, SIRT 1 and 2, unfolding an epigenetic regulation in stem cell differentiation and opening novel strategies for future therapeutic balancing of stem cell fate toward adipogenic or osteogenic phenotype.	Vitamin D	36-45	histone deacetylase 1	Homo sapiens	141-146
30326825-7	2018	Vitamin D signaling pathway activation was evaluated by measuring the expression levels of VDR, CYP24A1, Tumor necrosis factor alpha (TNFalpha) and cathelicidin (CAMP) by qRT-PCR.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	134-142
30356853-7	2018	The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17.	Vitamin D	151-160	interleukin 4	Homo sapiens	294-298
30305067-6	2018	A few cut- offs have correlated vitamin D deficiency to physiological markers such as parathyroid hormone (PTH), calcium and phosphate with varying results.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	86-105
30305067-6	2018	A few cut- offs have correlated vitamin D deficiency to physiological markers such as parathyroid hormone (PTH), calcium and phosphate with varying results.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	107-110
30305067-8	2018	Vitamin D (25(OH)D) levels were assayed and correlated with PTH, calcium and phosphate.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	60-63
30305067-15	2018	Vitamin D levels below 30 ng/mL was associated with a significant rise in PTH levels, suggesting that this cut off could be appropriate for defining Vitamin D deficiency in the population served by our laboratory.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	74-77
30305067-15	2018	Vitamin D levels below 30 ng/mL was associated with a significant rise in PTH levels, suggesting that this cut off could be appropriate for defining Vitamin D deficiency in the population served by our laboratory.	Vitamin D	149-158	parathyroid hormone	Homo sapiens	74-77
30364193-7	2018	Notably, some of these regions harbor genes, such as CYP27A1, CYP2J2, GC, SNAI2, and PIM1, that are directly involved in vitamin D metabolic pathway.	Vitamin D	121-130	sterol 26-hydroxylase, mitochondrial	Bos taurus	53-60
30364193-7	2018	Notably, some of these regions harbor genes, such as CYP27A1, CYP2J2, GC, SNAI2, and PIM1, that are directly involved in vitamin D metabolic pathway.	Vitamin D	121-130	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	85-89
30297679-1	2018	A novel pathway of vitamin D activation by CYP11A has previously been elucidated.	Vitamin D	19-28	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	43-49
30349256-2	2018	Through interaction with its receptor (VDR) and the related enzymes (CYP27B1, CYP24A1), vitamin D modulates neurodevelopment, neuroprotection, and immunomodulation.	Vitamin D	88-97	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
30132432-3	2018	We evaluated the influence of thirty-three SNP in eleven vitamin D pathway genes (DBP, DHCR7, RXRA, CYP2R1, CYP27B1, CYP24A1, CYP3A4, CYP27A1, LRP2, CUBN and VDR) resulting in URI risk in 725 adults in London, UK, using an additive model with adjustment for potential confounders and correction for multiple comparisons.	Vitamin D	57-66	D-box binding PAR bZIP transcription factor	Homo sapiens	82-85
30286768-9	2018	CONCLUSION: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF.	Vitamin D	73-82	insulin	Homo sapiens	154-161
30281599-7	2018	Accordingly, in Cyp27b1-/-mice, the pharmacological effects of exogenously administered active vitamin D derivatives can be analyzed without being affected by 1alpha,25D3.	Vitamin D	95-104	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	16-23
30169726-2	2018	Objectives: We aimed to explore functional vitamin D deficiency in pregnancy by investigating associations between vitamin D status, parathyroid hormone (PTH), and perinatal outcomes.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	133-152
28913556-8	2018	Furthermore, vitamin D induced mRNA expression of TGF-beta (p = 0.048), TNF-alpha (p = 0.006) and PD-L1 (p = 0.02) and tended to induce IL-10 expression (p = 0.06).	Vitamin D	13-22	transforming growth factor beta 1	Homo sapiens	50-58
30206904-0	2018	Association of Vitamin D and Parathyroid Hormone with Insulin Sensitivity, Beta Cell Function and Gestational Diabetes in Pregnancy: A Cross-Sectional, Observational Study.	Vitamin D	15-24	insulin	Homo sapiens	54-61
28913556-8	2018	Furthermore, vitamin D induced mRNA expression of TGF-beta (p = 0.048), TNF-alpha (p = 0.006) and PD-L1 (p = 0.02) and tended to induce IL-10 expression (p = 0.06).	Vitamin D	13-22	tumor necrosis factor	Homo sapiens	72-81
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	transforming growth factor beta 1	Homo sapiens	148-156
29859385-8	2018	Results of RT-PCR demonstrated that vitamin D and omega-3 fatty acid co-supplementation significantly downregulated gene expression of interleukin-1 (IL-1) (P = 0.03), and upregulated vascular endothelial growth factor (VEGF) (P = 0.004) in PBMCs of subjects with PCOS, when compared with placebo.	Vitamin D	36-45	vascular endothelial growth factor A	Homo sapiens	184-218
30076857-0	2018	Vitamin D inhibits palmitate-induced macrophage pro-inflammatory cytokine production by targeting the MAPK pathway.	Vitamin D	0-9	mitogen-activated protein kinase 3	Homo sapiens	102-106
30076857-7	2018	Treatment with the active form of vitamin D inhibited palmitate-induced TNF-alpha and IL-6 production in macrophages.	Vitamin D	34-43	tumor necrosis factor	Homo sapiens	72-81
30076857-7	2018	Treatment with the active form of vitamin D inhibited palmitate-induced TNF-alpha and IL-6 production in macrophages.	Vitamin D	34-43	interleukin 6	Homo sapiens	86-90
30076857-8	2018	Furthermore, vitamin D significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2).	Vitamin D	13-22	mitogen-activated protein kinase 8	Homo sapiens	80-103
30076857-8	2018	Furthermore, vitamin D significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2).	Vitamin D	13-22	mitogen-activated protein kinase 8	Homo sapiens	105-108
30076857-8	2018	Furthermore, vitamin D significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2).	Vitamin D	13-22	mitogen-activated protein kinase 1	Homo sapiens	114-155
30076857-8	2018	Furthermore, vitamin D significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2).	Vitamin D	13-22	mitogen-activated protein kinase 3	Homo sapiens	157-163
30076857-10	2018	Our data suggest that the attenuation of palmitate-induced TNF-alpha and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2.	Vitamin D	119-128	tumor necrosis factor	Homo sapiens	59-68
30076857-10	2018	Our data suggest that the attenuation of palmitate-induced TNF-alpha and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2.	Vitamin D	119-128	interleukin 6	Homo sapiens	73-77
30076857-10	2018	Our data suggest that the attenuation of palmitate-induced TNF-alpha and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2.	Vitamin D	119-128	mitogen-activated protein kinase 8	Homo sapiens	171-174
30076857-10	2018	Our data suggest that the attenuation of palmitate-induced TNF-alpha and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2.	Vitamin D	119-128	mitogen-activated protein kinase 3	Homo sapiens	179-185
30588363-10	2018	There was a significant negative correlation between vitamin D levels and executive function assessed by Trail Making Test (r=-0.399, p=0.03).	Vitamin D	53-62	TNF superfamily member 10	Homo sapiens	105-110
29859385-8	2018	Results of RT-PCR demonstrated that vitamin D and omega-3 fatty acid co-supplementation significantly downregulated gene expression of interleukin-1 (IL-1) (P = 0.03), and upregulated vascular endothelial growth factor (VEGF) (P = 0.004) in PBMCs of subjects with PCOS, when compared with placebo.	Vitamin D	36-45	vascular endothelial growth factor A	Homo sapiens	220-224
29859385-9	2018	CONCLUSIONS: Overall, the co-administration of vitamin D and omega-3 fatty acid for 12 weeks had beneficial effects on mental health parameters, serum total testosterone, hs-CRP, plasma TAC and MDA levels, and gene expression of IL-1 and VEGF among women with PCOS.	Vitamin D	47-56	vascular endothelial growth factor A	Homo sapiens	238-242
30056012-10	2018	Use of benzodiazepines (46.7%) and omission of vitamin D (51.5%) were the most common PIM and PPO, respectively.	Vitamin D	47-56	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	86-89
30281106-0	2018	Compared with Cow Milk, a Growing-Up Milk Increases Vitamin D and Iron Status in Healthy Children at 2 Years of Age: The Growing-Up Milk-Lite (GUMLi) Randomized Controlled Trial.	Vitamin D	52-61	Weaning weight-maternal milk	Bos taurus	37-41
30281106-0	2018	Compared with Cow Milk, a Growing-Up Milk Increases Vitamin D and Iron Status in Healthy Children at 2 Years of Age: The Growing-Up Milk-Lite (GUMLi) Randomized Controlled Trial.	Vitamin D	52-61	Weaning weight-maternal milk	Bos taurus	37-41
30281106-2	2018	Objective: We aimed to investigate the effect of a micronutrient-fortified, reduced-energy growing-up milk (GUMLi) compared with cow milk (CM) consumed for 1 y on dietary iron and vitamin D intakes and the status of New Zealand and Australian children at 2 y of age.	Vitamin D	180-189	Weaning weight-maternal milk	Bos taurus	102-106
29661598-8	2018	However, a decrease in IL6 levels over the 2 years significantly correlated with reaching a normal vitamin D level (OR=0.89 per+1pg/mL IL6 increase, 95% CI=0.81-0.97, P=0.015).	Vitamin D	99-108	interleukin 6	Homo sapiens	23-26
30305815-9	2018	Her unexplained hypercalcemia after a regular dose of calcium and active vitamin D supported an important role of MafB in the negative regulation of RANKL-mediated osteoclast differentiation.	Vitamin D	73-82	MAF bZIP transcription factor B	Homo sapiens	114-118
30113253-1	2018	The vitamin D-binding protein (DBP) occupies a key node in the regulation of the vitamin D system.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
29955908-4	2018	INTRODUCTION: In vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	51-70
29955908-4	2018	INTRODUCTION: In vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	72-75
29955908-5	2018	We assessed effects of PTH responses to vitamin D insufficiency on bone metabolism, density, and geometry.	Vitamin D	40-49	parathyroid hormone	Homo sapiens	23-26
30306783-6	2018	Basal ganglia calcification may bepresent in over a third of patients.CASR mutation analysis is required for diagnostic confirmation and to facilitate proper management, screeningand genetic counselling of affected family members.Treatment with calcium and activated vitamin D analogues should be reserved for symptomatic individuals due tothe risk of exacerbating hypercalciuria and its associated complications.	Vitamin D	267-276	calcium sensing receptor	Homo sapiens	70-74
29944852-8	2018	The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues.	Vitamin D	4-13	interleukin 6	Mus musculus	95-99
30216977-4	2018	Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-kappaB) pathway, and immune cells.	Vitamin D	36-45	nuclear factor kappa B subunit 1	Homo sapiens	186-208
30216977-4	2018	Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-kappaB) pathway, and immune cells.	Vitamin D	36-45	nuclear factor kappa B subunit 1	Homo sapiens	210-219
30208925-7	2018	The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform.	Vitamin D	60-69	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	107-114
30254488-10	2018	A significant correlation was found between FC values of SNHG16 expression and vitamin D levels.	Vitamin D	79-88	small nucleolar RNA host gene 16	Homo sapiens	57-63
30204798-6	2018	We observed an inverse correlation between CDH13 methylation (p = 0.045; r = -0.21) and serum vitamin D level whereas TIMP3 methylation (p = 0.021; r = -0.24) and DRD2 methylation (p = 0.056; r = -0.201) showed inverse correlation with supplementary vitamin D in the cancer cases.	Vitamin D	94-103	cadherin 13	Homo sapiens	43-48
30271381-2	2018	Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis.	Vitamin D	48-57	forkhead box O3	Homo sapiens	106-112
30271381-3	2018	Aim of the present study was to investigate common single nucleotide polymorphisms (SNP"s) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.	Vitamin D	246-255	forkhead box O3	Homo sapiens	94-100
30271381-3	2018	Aim of the present study was to investigate common single nucleotide polymorphisms (SNP"s) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.	Vitamin D	246-255	forkhead box O3	Homo sapiens	188-194
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	37-46	forkhead box O3	Homo sapiens	120-126
29788105-2	2018	We investigated whether this association differs by 2 functional variants in the vitamin D-binding protein (DBP) gene, group-specific component (GC), that encode for common protein isoforms Gc1s, Gc1f, and Gc2 linked to differences in vitamin D metabolism.	Vitamin D	81-90	D-box binding PAR bZIP transcription factor	Homo sapiens	108-111
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	104-113	forkhead box O3	Homo sapiens	120-126
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	104-113	forkhead box O3	Homo sapiens	120-126
29788105-2	2018	We investigated whether this association differs by 2 functional variants in the vitamin D-binding protein (DBP) gene, group-specific component (GC), that encode for common protein isoforms Gc1s, Gc1f, and Gc2 linked to differences in vitamin D metabolism.	Vitamin D	81-90	solute carrier family 25 member 18	Homo sapiens	206-209
30221529-3	2018	Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system.	Vitamin D	0-9	renin	Homo sapiens	35-40
30221529-9	2018	The logistic regression model showed that vitamin D deficiency was a predictor for the presence of CEA (P = 0.013).	Vitamin D	42-51	CEA cell adhesion molecule 3	Homo sapiens	99-102
30194148-2	2018	Here, the effect of vitamin D on p53-positive DU4475 cells and its ability to decrease the IC50 of PTX in these cells were investigated.	Vitamin D	20-29	tumor protein p53	Homo sapiens	33-36
29447022-0	2018	Correction to: Seyyed Abootorabi et al., The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.	Vitamin D	55-64	insulin	Homo sapiens	84-91
30018118-9	2018	Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment.Conclusions: In patients with NSCLC, vitamin D supplementation may improve survival of patients with early-stage lung adenocarcinoma with lower 25(OH)D levels.	Vitamin D	194-203	DEAH-box helicase 15	Homo sapiens	34-38
29447022-0	2018	Correction to: Seyyed Abootorabi et al., The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.	Vitamin D	55-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	121-132
29447022-0	2018	Correction to: Seyyed Abootorabi et al., The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.	Vitamin D	136-145	adiponectin, C1Q and collagen domain containing	Homo sapiens	121-132
30294564-7	2018	A trend towards a greater decrease in serum parathyroid hormone (PTH) levels was observed in vitamin D group compared to placebo group (-3.8 vs. +1.9, P = 0.07).	Vitamin D	93-102	parathyroid hormone	Homo sapiens	44-63
29684478-11	2018	In addition, vitamin D deficiency activated prostatic STAT3, a proliferation pathway in middle-aged mice.	Vitamin D	13-22	signal transducer and activator of transcription 3	Mus musculus	54-59
30246694-6	2018	Comparing different bowel habit subtypes, we observed that it was only in diarrhea predominant IBS (IBS-D) that vitamin D supplementation was able to significantly reduce the serum levels of TNF-alpha and IL-17 (P&lt;0.05).	Vitamin D	112-121	tumor necrosis factor	Homo sapiens	191-200
28662591-0	2018	Prevalence of vitamin D deficiency in pregnant mothers in Tehran and investigating its association with serum glucose and insulin.	Vitamin D	14-23	insulin	Homo sapiens	122-129
28662591-2	2018	(2) To identify any correlations between maternal vitamin D levels and maternal and newborns" glucose and insulin levels.	Vitamin D	50-59	insulin	Homo sapiens	106-113
30259785-6	2018	DISCUSSION &amp; CONCLUSION: DBP variations might be associated with risk factors in COPD caused by both inflammatory and vitamin D circulation processes.	Vitamin D	122-131	D-box binding PAR bZIP transcription factor	Homo sapiens	29-32
30009474-2	2018	Calcimimetics, agents that act on the calcium sensing receptor (CaSR), were designed to overcome limitations in the use of vitamin D sterols to treat SHPT, and have demonstrated efficacy in reducing levels of PTH in randomized trials.	Vitamin D	123-132	calcium sensing receptor	Homo sapiens	38-62
30009474-2	2018	Calcimimetics, agents that act on the calcium sensing receptor (CaSR), were designed to overcome limitations in the use of vitamin D sterols to treat SHPT, and have demonstrated efficacy in reducing levels of PTH in randomized trials.	Vitamin D	123-132	calcium sensing receptor	Homo sapiens	64-68
30177117-12	2018	In both groups of patients with estimated glomerular filtration rate above 60 mL/min/1.72 m2, vitamin D was significantly higher.	Vitamin D	94-103	CD59 molecule (CD59 blood group)	Homo sapiens	81-86
30200275-0	2018	Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors.	Vitamin D	43-52	protein disulfide isomerase family A member 3	Homo sapiens	108-113
30286768-0	2018	The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization.	Vitamin D	15-24	insulin	Homo sapiens	86-93
30286768-3	2018	Therefore, this study was conducted to determine the effects of vitamin D supplementation on the levels of anti-Mullerian hormone (AMH), metabolic profiles, and gene expression of insulin and lipid metabolism in infertile women with PCOS who were candidate for in vitro fertilization (IVF).	Vitamin D	64-73	insulin	Homo sapiens	180-187
29902012-0	2018	Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.	Vitamin D	39-48	epidermal growth factor receptor	Homo sapiens	89-93
30157189-5	2018	Vitamin D altered expression of a subset of these PM-induced genes, including suppressing IL6.	Vitamin D	0-9	interleukin 6	Homo sapiens	90-93
30157189-6	2018	Addition of vitamin D suppressed PM-stimulated IL-6 production, although to significantly greater extent in healthy versus asthmatic donor cultures.	Vitamin D	12-21	interleukin 6	Homo sapiens	47-51
30157189-9	2018	Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.	Vitamin D	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	39-44
30157189-9	2018	Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.	Vitamin D	19-28	interleukin 6	Homo sapiens	67-71
30210711-3	2018	Specifically, we aimed to investigate the effect of vitamin D on Th1 cells and elucidate the underlying molecular mechanism.	Vitamin D	52-61	negative elongation factor complex member C/D, Th1l	Mus musculus	65-68
29902012-12	2018	Our results demonstrated that the delivery of vitamin D-based drug payloads via tumor-targeted EGFR-LP has promise as a new therapy for EFGR TKI resistant lung cancer.	Vitamin D	46-55	epidermal growth factor receptor	Homo sapiens	95-99
29402723-0	2018	Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNgamma levels and cathelicidin expression.	Vitamin D	73-82	interferon gamma	Homo sapiens	123-131
30070873-10	2018	Individuals with inadequacy of vitamin D showed higher values of CRP in both groups (p = 0.000).	Vitamin D	31-40	C-reactive protein	Homo sapiens	65-68
30105198-0	2018	A molecular simulation analysis of vitamin D targets interleukin 13 (IL13) as an alternative to mometasone in asthma.	Vitamin D	35-44	interleukin 13	Homo sapiens	53-67
30105198-0	2018	A molecular simulation analysis of vitamin D targets interleukin 13 (IL13) as an alternative to mometasone in asthma.	Vitamin D	35-44	interleukin 13	Homo sapiens	69-73
30105198-10	2018	The docked complexes of mometasone and vitamin D with interleukin-13 were evaluated with molecular dynamics simulation.	Vitamin D	39-48	interleukin 13	Homo sapiens	54-68
30105198-11	2018	Consistently, the MD analysis uncovered the interesting note on conformational adaptation between the complexes as well as that vitamin D has the complementary binding efficiency to interleukin-13 as compared to mometasone.	Vitamin D	128-137	interleukin 13	Homo sapiens	182-196
29402723-8	2018	RESULTS: Serum levels of IL-10 and IFNgamma increased significantly in the group of patients with vitamin D supplementation, while IL-5, IL-9, and IL-13 decreased significantly.	Vitamin D	98-107	interferon gamma	Homo sapiens	35-43
30116326-2	2018	In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1beta, IL-6 and TNF-alpha in intervertebral disc lesions of patients.	Vitamin D	30-39	interleukin 1 beta	Homo sapiens	99-107
30116326-2	2018	In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1beta, IL-6 and TNF-alpha in intervertebral disc lesions of patients.	Vitamin D	30-39	interleukin 6	Homo sapiens	109-113
30116326-2	2018	In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1beta, IL-6 and TNF-alpha in intervertebral disc lesions of patients.	Vitamin D	30-39	tumor necrosis factor	Homo sapiens	118-127
30116326-10	2018	Further, the expression of cytokines IL-1beta, IL-6 and TNF-alpha in intervertebral disc lesion tissues of patients with spinal tuberculosis were significantly higher than those of patients with spinal tuberculosis whose vitamin D content was normal (P&lt;0.05).	Vitamin D	221-230	tumor necrosis factor	Homo sapiens	56-65
30116326-11	2018	In the control group, vitamin D content was negatively correlated with the expression of IL-1beta, IL-6 and TNF-alpha.	Vitamin D	22-31	interleukin 1 beta	Homo sapiens	89-97
30116326-11	2018	In the control group, vitamin D content was negatively correlated with the expression of IL-1beta, IL-6 and TNF-alpha.	Vitamin D	22-31	interleukin 6	Homo sapiens	99-103
30116326-11	2018	In the control group, vitamin D content was negatively correlated with the expression of IL-1beta, IL-6 and TNF-alpha.	Vitamin D	22-31	tumor necrosis factor	Homo sapiens	108-117
29975973-2	2018	Vitamin D is associated with impaired beta-cell function and insulin resistance, and is necessary for wound healing and bone metabolism.	Vitamin D	0-9	insulin	Homo sapiens	61-68
29533153-6	2018	In case of vitamin D deficiency during infertility treatment, vitamin D supplementation can be recommended especially for women who have PCOS, insulin resistance, or low anti-Mullerian hormone levels.	Vitamin D	62-71	insulin	Homo sapiens	143-150
29608042-0	2018	Vitamin D insufficiency is associated with insulin resistance independently of obesity in primary schoolchildren.	Vitamin D	0-9	insulin	Homo sapiens	43-50
29982544-9	2018	In addition, omega-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations.	Vitamin D	36-45	insulin	Homo sapiens	109-116
29982544-9	2018	In addition, omega-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations.	Vitamin D	36-45	insulin	Homo sapiens	118-125
29982544-9	2018	In addition, omega-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations.	Vitamin D	36-45	insulin	Homo sapiens	118-125
29608042-2	2018	OBJECTIVES: To explore the associations of vitamin D status and obesity with insulin resistance (IR) in children.	Vitamin D	43-52	insulin	Homo sapiens	77-84
29608042-8	2018	In line with the above, the results from logistic regression analyses controlled for several potential confounders, showed a 1.48 (95% C.I: 1.2-1.84) higher likelihood for vitamin D insufficiency for insulin resistant children compared to the non-insulin resistant ones, while no significant association was observed with obesity.	Vitamin D	172-181	insulin	Homo sapiens	200-207
29608042-8	2018	In line with the above, the results from logistic regression analyses controlled for several potential confounders, showed a 1.48 (95% C.I: 1.2-1.84) higher likelihood for vitamin D insufficiency for insulin resistant children compared to the non-insulin resistant ones, while no significant association was observed with obesity.	Vitamin D	172-181	insulin	Homo sapiens	247-254
29608042-9	2018	CONCLUSIONS: The present study revealed a high prevalence of vitamin D insufficiency among schoolchildren in Greece, particularly among obese and insulin resistant ones.	Vitamin D	61-70	insulin	Homo sapiens	146-153
30065237-2	2018	Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]).	Vitamin D	0-9	glial cell derived neurotrophic factor	Homo sapiens	224-228
30065252-3	2018	The group on high dose vitamin D (D++) developed the most severe colitis as measured by blinded endoscopic (p &lt; 0.001) and histologic (p &lt; 0.05) assessment, weight loss (p &lt; 0.001), drop in serum albumin (p = 0.05) and increased expression of colonic TNF-alpha (p &lt; 0.05).	Vitamin D	23-32	tumor necrosis factor	Mus musculus	260-269
30214848-3	2018	Some of the effects of vitamin D deficiency that will be discussed include the development of dementia caused by the increase of cerebral soluble and insoluble amyloid-beta (Abeta) peptides and a decrease of its anti-inflammatory/antioxidant properties, the link to depression by a reduction of the buffering of increased calcium in the brain, and vitamin D deficiency in expecting mothers linking to the development of autism and schizophrenic-like disorders, hypoxic brain injury, and other mental illnesses.	Vitamin D	23-32	amyloid beta precursor protein	Homo sapiens	174-179
29759135-3	2018	It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively.	Vitamin D	233-242	complement C3d receptor 2	Homo sapiens	28-32
29759135-3	2018	It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively.	Vitamin D	233-242	complement C3d receptor 2	Homo sapiens	103-107
30008960-0	2018	Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines.	Vitamin D	8-17	solute carrier family 6 member 4	Rattus norvegicus	99-103
30060745-13	2018	Vitamin D deficiency was not significantly associated with survival in the overall sample; however a trend was seen in the TN (5-years PFS 60.4% vs. 72.3%, p = 0.3), and in the hormone receptor positive /human epidermal growth factor receptor 2 negative (HER2-) subgroups (5-years PFS 89% vs 78%, p = 0.056).	Vitamin D	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	204-244
29527916-1	2018	Recently it has been shown that vitamin D(3) acting via its cognate receptor (VDR) regulates the growth, differentiation and function of female reproductive tissues including ovary.	Vitamin D	32-41	vitamin D receptor	Sus scrofa	78-81
30050908-11	2018	Conclusion: These findings suggest that vitamin D supplementation may act to protect against CVD through improving risk factors, including high blood pressure, elevated PTH, dyslipidemia, and inflammation.	Vitamin D	40-49	parathyroid hormone	Homo sapiens	169-172
29574006-2	2018	The enzyme deficiency leads to an impaired vitamin D catabolism pathway, resulting in a syndrome characterized by recurrent hypercalcemia, hypercalciuria and suppressed parathyroid hormone (PTH) levels.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	169-188
30057603-0	2018	Effects of Vitamin D Supplementation on Renin and Aldosterone Concentrations in Patients with Advanced Heart Failure: The EVITA Trial.	Vitamin D	11-20	renin	Homo sapiens	40-45
30057603-1	2018	Objective: 1,25-Dihydroxyvitamin D (1,25([OH]2D) is considered to be a negative endogenous regulator of the renin-angiotensin-aldosterone system (RAAS), but the effect of vitamin D supplementation on the RAAS is inconclusive.	Vitamin D	25-34	renin	Homo sapiens	108-113
30057603-7	2018	Vitamin D supplementation was, however, associated with an increase in renin concentrations in the subgroup with baseline 25-hydroxyvitamin D below 30 nmol/L (n = 67; 1365 mIU/, 343 to 2386 mIU/L; P = 0.010).	Vitamin D	0-9	renin	Homo sapiens	71-76
30057603-8	2018	Conclusions: In patients with advanced heart failure treated according to evidence-based guidelines, vitamin D supplementation did not significantly influence parameters of the RAAS in the entire study cohort but was associated with an increase in plasma renin concentrations in the subgroup with low baseline 25-hydroxyvitamin D concentrations.	Vitamin D	101-110	renin	Homo sapiens	255-260
31149286-13	2018	Conclusion: The association of vitamin D with blood pressure, plasma lipids, glucose and insulin is very weak on an individual level.	Vitamin D	31-40	insulin	Homo sapiens	89-96
29476020-8	2018	In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes.	Vitamin D	15-24	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
29476020-8	2018	In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes.	Vitamin D	15-24	insulin like growth factor 1	Homo sapiens	121-149
29465004-0	2018	Insulin resistance in an animal model of polycystic ovary disease is aggravated by vitamin D deficiency: Vascular consequences.	Vitamin D	83-92	insulin	Homo sapiens	0-7
29476020-8	2018	In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes.	Vitamin D	15-24	AKT serine/threonine kinase 1	Homo sapiens	195-198
29677006-6	2018	Although vitamin D sterols raise these risk markers when lowering parathyroid hormone (PTH), calcimimetics lower them.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	66-85
30078941-2	2018	Correction of vitamin D deficiency in such patients was found to be significantly associated with weight reduction and improved insulin sensitivity.	Vitamin D	14-23	insulin	Homo sapiens	128-135
29465004-3	2018	We aimed to check a potential interplay between hyperandrogenism and vitamin D deficiency in producing insulin resistance and effects on coronary resistance arteries.	Vitamin D	69-78	insulin	Homo sapiens	103-110
29465004-9	2018	Vitamin D deficiency elevated postprandial insulin levels and homeostatic model assessment insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	43-50
29465004-11	2018	Our conclusion is that both hyperandrogenism and vitamin D deficiency reduce sensitivity of coronary vascular tissue to insulin, but they do it with different mechanisms.	Vitamin D	49-58	insulin	Homo sapiens	120-127
30127557-8	2018	Both SS and SB with low vitamin D had higher VLDL (P = 0.006 and P = 0.022), TNF-alpha (P = 0.001) and regulatory T cells (P = 0.000) compared to AS-low vitamin D.	Vitamin D	24-33	tumor necrosis factor	Homo sapiens	77-86
29963162-3	2018	In the present study, it is demonstrated that active vitamin D treatment prohibited the proliferation and invasion of ovarian cancer cells, and the expression level of a germ cell specific marker DEAD (Asp-Glu-Ala-Asp)-box helicase 4 (DDX4), which is overexpressed in ovarian cancer, was downregulated by active vitamin D treatment.	Vitamin D	53-62	DEAD-box helicase 4	Homo sapiens	235-239
29781720-1	2018	Vitamin D (vit-D) deficiency is highly prevalent in patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NET) and has been linked to reduced overall survival.	Vitamin D	0-9	granulin precursor	Homo sapiens	114-117
29781720-1	2018	Vitamin D (vit-D) deficiency is highly prevalent in patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NET) and has been linked to reduced overall survival.	Vitamin D	11-16	granulin precursor	Homo sapiens	114-117
30221147-10	2018	Conclusion: Vitamin D deficiency was common in all IBD patients, but more pronounced in CD patients, in whom it also showed a significant inverse association with inflammatory markers such as CRP and FC.	Vitamin D	12-21	C-reactive protein	Homo sapiens	192-195
29857907-0	2018	Vitamin D deficiency may stimulate fibroblasts in Dupuytren"s disease via mitochondrial increased reactive oxygen species through upregulating transforming growth factor-beta1.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	143-175
29963162-3	2018	In the present study, it is demonstrated that active vitamin D treatment prohibited the proliferation and invasion of ovarian cancer cells, and the expression level of a germ cell specific marker DEAD (Asp-Glu-Ala-Asp)-box helicase 4 (DDX4), which is overexpressed in ovarian cancer, was downregulated by active vitamin D treatment.	Vitamin D	312-321	DEAD-box helicase 4	Homo sapiens	235-239
29719203-0	2018	The burgeoning role of cytochrome P450-mediated vitamin D metabolites against colorectal cancer.	Vitamin D	48-57	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-38
30283909-2	2018	Activation of vitamin D by renal 1alpha-hydroxylation is dependent on protein binding because 1,25-dihydroxyvitamin D (1,25(OH)2D3) is formed after megalin-mediated reabsorption of 25-hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP).	Vitamin D	14-23	D-box binding PAR bZIP transcription factor	Homo sapiens	245-248
29857907-8	2018	TGF-beta1 increases mitochondrial ROS production in patients with Dupuytren"s contracture potentially in consequence of Vitamin D deficiency, leading to myofibroblast differentiation.	Vitamin D	120-129	transforming growth factor beta 1	Homo sapiens	0-9
29955369-2	2018	The goal of this study was to assess parathyroid hormone (PTH) in its relationship to vitamin D and inflammation, as well as to better understand the role of human cathelicidin (LL-37) in pSLE.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	37-56
29955369-2	2018	The goal of this study was to assess parathyroid hormone (PTH) in its relationship to vitamin D and inflammation, as well as to better understand the role of human cathelicidin (LL-37) in pSLE.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	58-61
29653103-2	2018	Both 25-hydroxy vitamin D3 1alpha-hydroxylase (CYP27B1) and 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) modulate blood levels of 1,25-dihydroxyvitamin D3, an activated form of vitamin D.	Vitamin D	16-25	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	47-54
28918533-16	2018	Furthermore (probably in the C allele carrier group), lower vitamin D intake, coupled with adherence to a traditional dietary pattern, reduces the deposition of TGF-beta and increases the risk of lumbar spine osteoporosis.	Vitamin D	60-69	transforming growth factor beta 1	Homo sapiens	161-169
29767851-7	2018	Lower 25-OHD levels were also associated with increased expression of CYP3A4, and with decreased expression of GC (also termed DBP) and VDR, three genes involved in vitamin D metabolism.	Vitamin D	165-174	D-box binding PAR bZIP transcription factor	Homo sapiens	127-130
29947185-9	2018	An immunohistochemical study showed increased expression of interleukin 6 (IL-6) and tumor necrosis factor alpha in rats manifesting vitamin D deficiency and decreased expression of IL-10 compared with controls.	Vitamin D	133-142	interleukin 6	Rattus norvegicus	60-73
29947185-9	2018	An immunohistochemical study showed increased expression of interleukin 6 (IL-6) and tumor necrosis factor alpha in rats manifesting vitamin D deficiency and decreased expression of IL-10 compared with controls.	Vitamin D	133-142	interleukin 6	Rattus norvegicus	75-79
29947185-9	2018	An immunohistochemical study showed increased expression of interleukin 6 (IL-6) and tumor necrosis factor alpha in rats manifesting vitamin D deficiency and decreased expression of IL-10 compared with controls.	Vitamin D	133-142	tumor necrosis factor	Rattus norvegicus	85-112
30600944-10	2018	The significant best-fitting predictors of vitamin D deficiency were living in rural area (OR=4.030, P &lt; 0.021) and eGFR &lt; 60 (OR=5.412, P &lt; 0.034).	Vitamin D	43-52	epidermal growth factor receptor	Homo sapiens	119-123
30600944-12	2018	Low eGFR &lt; 60, Alb/creat ratio more than 30 mg/24h and HbA1c &gt; 9 could be considered as predictive factors of vitamin D deficiency in these patients.	Vitamin D	116-125	epidermal growth factor receptor	Homo sapiens	4-8
29271278-0	2018	The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.	Vitamin D	14-23	insulin	Homo sapiens	43-50
29271278-0	2018	The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.	Vitamin D	14-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	80-91
29271278-0	2018	The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial.	Vitamin D	95-104	adiponectin, C1Q and collagen domain containing	Homo sapiens	80-91
29271278-2	2018	Vitamin D deficiency may contribute to the development of insulin resistance, visceral fat and low level of adiponectin which are common feature in PCOS women.	Vitamin D	0-9	insulin	Homo sapiens	58-65
29271278-2	2018	Vitamin D deficiency may contribute to the development of insulin resistance, visceral fat and low level of adiponectin which are common feature in PCOS women.	Vitamin D	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	108-119
29271278-3	2018	This study aimed to evaluate the effect of vitamin D supplementation on insulin resistance, visceral fat, and adiponectin in hypovitaminosis D women with polycystic ovary syndrome.	Vitamin D	43-52	insulin	Homo sapiens	72-79
29271278-3	2018	This study aimed to evaluate the effect of vitamin D supplementation on insulin resistance, visceral fat, and adiponectin in hypovitaminosis D women with polycystic ovary syndrome.	Vitamin D	43-52	adiponectin, C1Q and collagen domain containing	Homo sapiens	110-121
29271278-9	2018	CONCLUSION: Vitamin D supplementation in vitamin D deficient women with PCOS, improved the FPG, HOMA-B, Adiponectin, and serum vitamin D level.	Vitamin D	12-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	104-115
29452294-3	2018	We evaluated the impact of polymorphisms in genes (CYP27B1, CYP24A1, VDBP and VDR) related to vitamin D pathway on sofosbuvir and GS-331007 plasma levels in HCV mono-infected patients at one month of treatment.	Vitamin D	94-103	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	51-58
29478008-0	2018	Vitamin D status in prepubertal children with isolated idiopathic growth hormone deficiency: effect of growth hormone therapy.	Vitamin D	0-9	growth hormone 1	Homo sapiens	66-80
29478008-1	2018	Few studies, and with controversial results, analyzed vitamin D status in children before and after growth hormone (GH) treatment.	Vitamin D	54-63	growth hormone 1	Homo sapiens	116-118
29478008-2	2018	Thus, we aimed to assess vitamin D status in prepubertal children with idiopathic growth hormone deficiency (GHD), and to evaluate the effect of GHD and GH treatment on vitamin D levels.	Vitamin D	25-34	growth hormone 1	Homo sapiens	109-111
29217467-5	2018	In the circulation, vitamin D - like other steroid hormones - is bound tightly to a special carrier - vitamin D-binding protein (DBP).	Vitamin D	20-29	D-box binding PAR bZIP transcription factor	Homo sapiens	129-132
29217467-9	2018	Diseases or conditions that affect the synthesis of DBP or albumin thus have a huge impact on the amount of circulating total vitamin D.	Vitamin D	126-135	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
29217467-10	2018	DBP and albumin are synthesized in the liver, hence all patients with an impairment of liver function have alterations in their total vitamin D blood concentrations, while free vitamin D levels remain mostly constant.	Vitamin D	134-143	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
29217467-10	2018	DBP and albumin are synthesized in the liver, hence all patients with an impairment of liver function have alterations in their total vitamin D blood concentrations, while free vitamin D levels remain mostly constant.	Vitamin D	177-186	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
29217467-13	2018	The vitamin D-DBP as well as vitamin D-albumin complexes are filtered through the glomeruli and re-uptaken by megalin in the proximal tubule.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	14-17
29331722-0	2018	Effect of vitamin D supplementation on serum sclerostin levels in chronic kidney disease.	Vitamin D	10-19	sclerostin	Homo sapiens	45-55
29502202-4	2018	We genotyped many variants in three human genes encoding key components of the vitamin D metabolism, CYP2R1, CYP27B1, GC.	Vitamin D	79-88	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	109-116
29914667-1	2018	As the major vitamin D binding protein (DBP), the group-specific component (GC) plays an important role in the bioactivity of vitamin D.	Vitamin D	13-22	D-box binding PAR bZIP transcription factor	Homo sapiens	40-43
29501468-10	2018	Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-gamma in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-gamma r = 0.6, p = 0.015).	Vitamin D	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
29501468-10	2018	Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-gamma in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-gamma r = 0.6, p = 0.015).	Vitamin D	51-60	interferon gamma	Homo sapiens	82-91
29501468-10	2018	Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-gamma in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-gamma r = 0.6, p = 0.015).	Vitamin D	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
29501468-11	2018	Vitamin D was inversely correlated with IL-6 (r = -0.36, p = 0.044) in critically ill controls.	Vitamin D	0-9	interleukin 6	Homo sapiens	40-44
29501468-13	2018	In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-gamma.	Vitamin D	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
29501468-13	2018	In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-gamma.	Vitamin D	24-33	interferon gamma	Homo sapiens	86-95
29881333-0	2018	Maternal and early-life vitamin D deficiency enhances allergic reaction in an ovalbumin-sensitized BALB/c mouse model.	Vitamin D	24-33	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	78-87
30134801-0	2018	Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	22-25
30134801-3	2018	We therefore sought evidence for dysregulation of the PTH-FGF23-vitamin D axis in RRMS.	Vitamin D	64-73	parathyroid hormone	Homo sapiens	54-57
30134801-12	2018	CONCLUSIONS: This study revealed a dysequilibrium of the PTH-FGF23-vitamin D axis in RRMS, with lower plasma PTH, higher plasma iFGF23 and a lower serum 1,25(OH)2D to 25OHD ratio in RRMS compared with HC subjects.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	57-60
29951596-12	2018	Vitamin D supplementation and improved vitamin D status improved glycemic measures and insulin sensitivity and may be useful as part of a preventive strategy for type 2 diabetes.	Vitamin D	0-9	insulin	Homo sapiens	87-94
29951596-12	2018	Vitamin D supplementation and improved vitamin D status improved glycemic measures and insulin sensitivity and may be useful as part of a preventive strategy for type 2 diabetes.	Vitamin D	39-48	insulin	Homo sapiens	87-94
29705446-0	2018	The effects of different combinations of perceptual-motor exercises, music, and vitamin D supplementation on the nerve growth factor in children with high-functioning autism.	Vitamin D	80-89	nerve growth factor	Homo sapiens	113-132
29547433-2	2018	Vitamin D has immunoregulatory functions, including inducing the development of T cells and higher levels may improve CD4 rebound.	Vitamin D	0-9	CD4 molecule	Homo sapiens	118-121
29547433-5	2018	We estimated the adjusted effect (adjusted for pre-HAART antiretroviral exposure, black race, age and CD4 at HAART initiation) of pre-HAART and post-HAART vitamin D metabolite levels on the rate of CD4 increase and final CD4 plateau.	Vitamin D	155-164	CD4 molecule	Homo sapiens	198-201
29547433-5	2018	We estimated the adjusted effect (adjusted for pre-HAART antiretroviral exposure, black race, age and CD4 at HAART initiation) of pre-HAART and post-HAART vitamin D metabolite levels on the rate of CD4 increase and final CD4 plateau.	Vitamin D	155-164	CD4 molecule	Homo sapiens	198-201
29750812-2	2018	The emission bands in non-heated desi ghee centred at 375 nm is labelled for vitamin D, 390 nm for vitamin K, 440-460 nm for isomers of conjugated linoleic acid (CLA), 490 nm for vitamin A and the region 620-700 nm is assigned to chlorophyll contents.	Vitamin D	77-86	desumoylating isopeptidase 2	Homo sapiens	33-37
29771914-2	2018	Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation.	Vitamin D	0-9	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	75-82
29771914-2	2018	Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	145-152
29769621-7	2018	Progressive trends (P &lt; 0.05) towards increased CD8 and CD4/CD8 were observed in vitamin-D-deficient T2DM and hypertension patients.	Vitamin D	84-93	CD4 molecule	Homo sapiens	59-62
29526777-7	2018	DBP was downregulated in oxyphil nodules on protein level, which may contribute to calcitriol resistance by reducing vitamin D transport.	Vitamin D	117-126	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
29526777-14	2018	It is noteworthy that DBP was downregulated in oxyphil nodules on protein level and may therefore participate in the resistance of calcitriol therapy by reducing the vitamin D transport capacity.	Vitamin D	166-175	D-box binding PAR bZIP transcription factor	Homo sapiens	22-25
29725526-0	2018	Effect of vitamin D supplementation on fasting plasma glucose, insulin resistance and prevention of type 2 diabetes mellitus in non-diabetics: A systematic review and meta-analysis.	Vitamin D	10-19	insulin	Homo sapiens	63-70
29725526-2	2018	Therefore, randomized clinical trials (RCTs) have been performed to observe the effect of vitamin D supplementation on preventing T2DM, decreasing fasting plasma glucose (FPG) and improving insulin resistance to confirm the association between vitamin D and T2DM.	Vitamin D	90-99	insulin	Homo sapiens	190-197
29705446-1	2018	The present study investigated the effects of different combinations of perceptual-motor exercises, music, and Vitamin D consumption on the nerve growth factor (NGF) in children with high-functioning autism.	Vitamin D	111-120	nerve growth factor	Homo sapiens	140-159
29705446-6	2018	In addition, the intake of Vitamin D along with perceptual-motor exercises resulted in a significant increase in the levels of NGF compared to Groups A, B and D. These findings suggest that perceptual-motor exercises along with music as well as taking Vitamin D may provide two appropriate interventions for improving NGF in children with autism.	Vitamin D	27-36	nerve growth factor	Homo sapiens	127-130
29705446-6	2018	In addition, the intake of Vitamin D along with perceptual-motor exercises resulted in a significant increase in the levels of NGF compared to Groups A, B and D. These findings suggest that perceptual-motor exercises along with music as well as taking Vitamin D may provide two appropriate interventions for improving NGF in children with autism.	Vitamin D	27-36	nerve growth factor	Homo sapiens	318-321
29705446-6	2018	In addition, the intake of Vitamin D along with perceptual-motor exercises resulted in a significant increase in the levels of NGF compared to Groups A, B and D. These findings suggest that perceptual-motor exercises along with music as well as taking Vitamin D may provide two appropriate interventions for improving NGF in children with autism.	Vitamin D	252-261	nerve growth factor	Homo sapiens	127-130
29743660-6	2018	CONCLUSION: Preterm infant vitamin D status was significantly associated with PTH status and femur mineralization with suggestion that achieving a specific 25-hydroxyvitamin concentration is associated with optimal calcium homeostasis and femur bone mineralization.	Vitamin D	27-36	parathyroid hormone	Homo sapiens	78-81
29461981-0	2018	CYP3A4 mutation causes vitamin D-dependent rickets type 3.	Vitamin D	23-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
29461981-4	2018	In vitro, the mutant CYP3A4 oxidized 1,25-dihydroxyvitamin D with 10-fold greater activity than WT CYP3A4 and 2-fold greater activity than CYP24A1, the principal inactivator of vitamin D metabolites.	Vitamin D	51-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27
29461981-4	2018	In vitro, the mutant CYP3A4 oxidized 1,25-dihydroxyvitamin D with 10-fold greater activity than WT CYP3A4 and 2-fold greater activity than CYP24A1, the principal inactivator of vitamin D metabolites.	Vitamin D	51-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105
29461981-5	2018	As CYP3A4 mutations have not previously been linked to rickets, these findings provide insight into vitamin D metabolism and demonstrate that accelerated inactivation of vitamin D metabolites represents a mechanism for vitamin D deficiency.	Vitamin D	100-109	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	3-9
29461981-5	2018	As CYP3A4 mutations have not previously been linked to rickets, these findings provide insight into vitamin D metabolism and demonstrate that accelerated inactivation of vitamin D metabolites represents a mechanism for vitamin D deficiency.	Vitamin D	170-179	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	3-9
29461981-5	2018	As CYP3A4 mutations have not previously been linked to rickets, these findings provide insight into vitamin D metabolism and demonstrate that accelerated inactivation of vitamin D metabolites represents a mechanism for vitamin D deficiency.	Vitamin D	170-179	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	3-9
29742726-9	2018	Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes.	Vitamin D	104-113	insulin like growth factor 1	Homo sapiens	56-61
29742726-12	2018	This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction.	Vitamin D	83-92	insulin like growth factor 1	Homo sapiens	48-53
29742726-12	2018	This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction.	Vitamin D	173-182	insulin like growth factor 1	Homo sapiens	48-53
29742726-13	2018	Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population.	Vitamin D	113-122	insulin like growth factor 1	Homo sapiens	40-45
29657326-4	2018	In addition, recent studies have revealed that vitamin D can also be metabolized and activated through a CYP11A1-driven non-canonical metabolic pathway.	Vitamin D	47-56	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	105-112
29571607-12	2018	We hypothesized that vitamin D might reduce the risk for TFI through suppressing the production of IL-6.	Vitamin D	21-30	interleukin 6	Homo sapiens	99-103
29281615-0	2018	Vitamin D ameliorates neonatal necrotizing enterocolitis via suppressing TLR4 in a murine model.	Vitamin D	0-9	toll-like receptor 4	Mus musculus	73-77
29693337-0	2018	Impact of Mesenchymal Stem Cells and Vitamin D on Transforming Growth Factor Beta Signaling Pathway in Hepatocellular Carcinoma in Rats Background: Transforming growth factor-beta (TGF-beta) signaling is recognized as being critical for carcinogenesis.Vitamin D has proved to exert numerous tumor suppressive effects.	Vitamin D	37-46	transforming growth factor, beta 1	Rattus norvegicus	181-189
29693337-0	2018	Impact of Mesenchymal Stem Cells and Vitamin D on Transforming Growth Factor Beta Signaling Pathway in Hepatocellular Carcinoma in Rats Background: Transforming growth factor-beta (TGF-beta) signaling is recognized as being critical for carcinogenesis.Vitamin D has proved to exert numerous tumor suppressive effects.	Vitamin D	252-261	transforming growth factor, beta 1	Rattus norvegicus	181-189
29693337-2	2018	The present study was conducted to evaluate the effectsof BM-MSCs and vitamin D on TGF-beta signaling in an experimental hepatocellular carcinoma (HCC) model in rats.Materials and Methods: The study was conducted on fifty female white albino rats divided equally into 5 groups:controls, HCC induced by diethyl-nitrosamine (DENA) and carbon tetrachloride (CCl4), HCC plus MSCs, HCC plusvitamin D and HCC plus both MSCs and vitamin D. The following parameters were assessed in rat liver tissues: TGF-betaand Smad2 protein levels by ELISA and western blotting, respectively, gene expression of Smad3, Smad7, Snail,HNF4alpha and MMP-2 and histopathological lesions.	Vitamin D	70-79	transforming growth factor, beta 1	Rattus norvegicus	83-91
29693337-2	2018	The present study was conducted to evaluate the effectsof BM-MSCs and vitamin D on TGF-beta signaling in an experimental hepatocellular carcinoma (HCC) model in rats.Materials and Methods: The study was conducted on fifty female white albino rats divided equally into 5 groups:controls, HCC induced by diethyl-nitrosamine (DENA) and carbon tetrachloride (CCl4), HCC plus MSCs, HCC plusvitamin D and HCC plus both MSCs and vitamin D. The following parameters were assessed in rat liver tissues: TGF-betaand Smad2 protein levels by ELISA and western blotting, respectively, gene expression of Smad3, Smad7, Snail,HNF4alpha and MMP-2 and histopathological lesions.	Vitamin D	70-79	transforming growth factor, beta 1	Rattus norvegicus	83-86
29695305-1	2018	BACKGROUND: Vitamin D deficiency is associated with an increased risk of Alzheimer"s disease and increased beta-amyloid (Abeta) in animals.	Vitamin D	12-21	amyloid beta precursor protein	Homo sapiens	121-126
29684027-10	2018	Meanwhile, our study suggests that restoration of systemic and intestinal vitamin D deficiency using by chronic vitamin D treatment effectively reduces TNFalpha-mediated immunological abnormalities associated with the gut-adipose tissue-liver axis and hepatic steatosis in NASH rats.	Vitamin D	74-83	tumor necrosis factor	Rattus norvegicus	152-160
29684027-10	2018	Meanwhile, our study suggests that restoration of systemic and intestinal vitamin D deficiency using by chronic vitamin D treatment effectively reduces TNFalpha-mediated immunological abnormalities associated with the gut-adipose tissue-liver axis and hepatic steatosis in NASH rats.	Vitamin D	112-121	tumor necrosis factor	Rattus norvegicus	152-160
29609719-12	2018	Consequently, vitamin D deficiency should be considered in the management of RLS.	Vitamin D	14-23	RLS1	Homo sapiens	77-80
29609719-2	2018	Vitamin D may play a role in the pathophysiology of RLS by modulating the dopaminergic system.	Vitamin D	0-9	RLS1	Homo sapiens	52-55
29609719-3	2018	The aim of our study is to examine the possible link between RLS and vitamin D deficiency.	Vitamin D	69-78	RLS1	Homo sapiens	61-64
29609719-7	2018	RESULTS: Fifty-nine patients with RLS (75.6%) and 52 controls (42.3%) had a diagnosis of vitamin D deficiency, P < .001.	Vitamin D	89-98	RLS1	Homo sapiens	34-37
29609719-8	2018	The odds ratio (OR) of the development of RLS was 4.24 for those with a vitamin D level < 50 nmol/L compared to those with a vitamin D level >= 50 nmol/L (P < .001, 95% confidence interval [CI] 2.3-7.9).	Vitamin D	72-81	RLS1	Homo sapiens	42-45
29609719-8	2018	The odds ratio (OR) of the development of RLS was 4.24 for those with a vitamin D level < 50 nmol/L compared to those with a vitamin D level >= 50 nmol/L (P < .001, 95% confidence interval [CI] 2.3-7.9).	Vitamin D	125-134	RLS1	Homo sapiens	42-45
29609719-9	2018	After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P < .002, 95% CI 1.51-6.38).	Vitamin D	86-95	RLS1	Homo sapiens	130-133
29609719-11	2018	CONCLUSIONS: Our study identified an association between vitamin D deficiency and RLS.	Vitamin D	57-66	RLS1	Homo sapiens	82-85
29524864-13	2018	Vitamin D was an independent predictor of decreased CD34 + levels in PsA and RA.	Vitamin D	0-9	CD34 molecule	Homo sapiens	52-56
29488238-8	2018	The composite results show that vitamin D analogs 1alpha(OH)D3 and 25(OH)D3 exhibit cholesterol lowering properties upon activation to 1,25(OH)2 D3 : 1alpha(OH)D3 is rapidly activated by liver enzymes and 25(OH)D3 is slowly activated by renal Cyp27b1 in mouse.	Vitamin D	32-41	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	243-250
29739069-4	2018	We pooled the data and analyzed the association between vitamin D level and sepsis risk, death, and albumin (ALB), mortality, body mass index (BMI), procalcitonin (PCT), male/female ratio, interleukin-6 (IL-6), platelet (PLT), c-reactive protein (CRP) and white blood cell (WBC).	Vitamin D	56-65	albumin	Homo sapiens	100-107
29658832-1	2018	OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM).	Vitamin D	53-62	parathyroid hormone	Homo sapiens	119-122
29658832-12	2018	PTH is an important risk factor responsible for the higher 10-year probability of osteoporotic fractures in diabetic patients, especially in those with lower vitamin D levels.	Vitamin D	158-167	parathyroid hormone	Homo sapiens	0-3
29196501-1	2018	Research has identified reduced circulating 25-hydroxyvitamin D [25(OH)D] in individuals with the rs7041 (c.1296T&gt;G) T allele in the vitamin D binding protein gene ( GC); however, the effects of the T allele on vitamin D biomarkers during pregnancy and lactation are unknown.	Vitamin D	54-63	D-box binding PAR bZIP transcription factor	Homo sapiens	144-161
29248753-0	2018	The study of vitamin D administration effect on CRP and Interleukin-6 as prognostic biomarkers of ventilator associated pneumonia.	Vitamin D	13-22	C-reactive protein	Homo sapiens	48-51
29248753-0	2018	The study of vitamin D administration effect on CRP and Interleukin-6 as prognostic biomarkers of ventilator associated pneumonia.	Vitamin D	13-22	interleukin 6	Homo sapiens	56-69
29248753-6	2018	Although C-Reactive protein (CRP) levels showed an improving trend in the vitamin D group, no significant difference between groups (P=0.12) was found.	Vitamin D	74-83	C-reactive protein	Homo sapiens	9-27
29248753-6	2018	Although C-Reactive protein (CRP) levels showed an improving trend in the vitamin D group, no significant difference between groups (P=0.12) was found.	Vitamin D	74-83	C-reactive protein	Homo sapiens	29-32
29248753-8	2018	CONCLUSION: Our results indicate that vitamin D administration can significantly reduce the IL-6 as prognostic marker in VAP patients, and must be considered as adjunct option in the treatment of VAP patients.	Vitamin D	38-47	interleukin 6	Homo sapiens	92-96
28455680-8	2018	In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH.	Vitamin D	51-60	parathyroid hormone	Homo sapiens	105-108
29504254-0	2018	Effect of Vitamin D Supplementation on Obesity-Induced Insulin Resistance: A Double-Blind, Randomized, Placebo-Controlled Trial.	Vitamin D	10-19	insulin	Homo sapiens	55-62
29504254-1	2018	OBJECTIVE: The aim was to investigate whether vitamin D supplementation, combined with a hypocaloric diet, could have an independent effect on insulin sensitivity in subjects with both overweight and hypovitaminosis D. Changes from baseline in anthropometric parameters, body composition, glucose tolerance, and insulin secretion were considered as secondary outcomes.	Vitamin D	46-55	insulin	Homo sapiens	143-150
29504254-6	2018	Insulin sensitivity in the vitamin D group improved (from 4.6 +- 2.0 to 6.9 +- 3.3 mg kg-1  min-1 ; P &lt; 0.001), whereas no changes were observed in the placebo group (from 4.9 +- 1.1 to 5.1 +- 0.3 mg kg-1  min-1 ; P = 0.84).	Vitamin D	27-36	insulin	Homo sapiens	0-7
29504254-6	2018	Insulin sensitivity in the vitamin D group improved (from 4.6 +- 2.0 to 6.9 +- 3.3 mg kg-1  min-1 ; P &lt; 0.001), whereas no changes were observed in the placebo group (from 4.9 +- 1.1 to 5.1 +- 0.3 mg kg-1  min-1 ; P = 0.84).	Vitamin D	27-36	CD59 molecule (CD59 blood group)	Homo sapiens	92-97
29504254-6	2018	Insulin sensitivity in the vitamin D group improved (from 4.6 +- 2.0 to 6.9 +- 3.3 mg kg-1  min-1 ; P &lt; 0.001), whereas no changes were observed in the placebo group (from 4.9 +- 1.1 to 5.1 +- 0.3 mg kg-1  min-1 ; P = 0.84).	Vitamin D	27-36	CD59 molecule (CD59 blood group)	Homo sapiens	209-214
31089541-10	2018	In multivariate logistic analysis, after adjustment for age, sex, body mass index, glycated hemoglobin and homeostasis model assessment of insulin resistance, patients with type 2 diabetes in the vitamin D sufficient group showed significantly lower odds ratio for nonalcoholic fatty liver disease than those within the vitamin D deficient group.	Vitamin D	196-205	insulin	Homo sapiens	139-146
29470176-4	2018	The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth factors in pre-pubertal girls with VDD.	Vitamin D	91-100	parathyroid hormone	Homo sapiens	115-118
29470176-11	2018	The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D.	Vitamin D	85-94	insulin like growth factor 1	Homo sapiens	10-15
29470176-13	2018	Vitamin D supplementation resulted in a significant increase in serum IGF-1 levels in VDD pre-pubertal girls.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	70-75
29633734-2	2018	Currently available treatments for HPT include high dose vitamin D (ergocalciferol, D2 and cholecalciferol, D3) or, the active metabolite dihydroxy vitamin D (calcitriol), in addition to calcium supplements.This regimen, if not well monitored, can lead to hypercalciuria, as PTH deficiency impairs renal calcium reabsorption.	Vitamin D	57-66	HPT	Homo sapiens	35-38
29892562-3	2018	Parallel to the obesity and diabetes epidemics, the prevalence of vitamin D deficiency has reached very high levels and has been associated with insulin resistance and dyslipidemia.	Vitamin D	66-75	insulin	Homo sapiens	145-152
29892562-4	2018	Studies exploring the impact of vitamin D repletion on insulin sensitivity and dyslipidemia in children are sparse.The aim of this study was to determine the impact of treatment with vitamin D (ergocalciferol) in obese African American (AA) children on vitamin D levels and insulin secretion and sensitivity.	Vitamin D	32-41	insulin	Homo sapiens	55-62
29568200-7	2018	In a larger cohort of patients and controls, a disease-associated expression pattern, with higher transcript levels in vitamin D-treated PBMCs from patients, was observed for three of these genes, CLEC5A (P &lt; 0.030), lysozyme (LYZ; P &lt; 0.047) and TREM1 (P &lt; 0.023).	Vitamin D	119-128	C-type lectin domain containing 5A	Homo sapiens	197-203
29568200-7	2018	In a larger cohort of patients and controls, a disease-associated expression pattern, with higher transcript levels in vitamin D-treated PBMCs from patients, was observed for three of these genes, CLEC5A (P &lt; 0.030), lysozyme (LYZ; P &lt; 0.047) and TREM1 (P &lt; 0.023).	Vitamin D	119-128	lysozyme	Homo sapiens	220-228
29568200-7	2018	In a larger cohort of patients and controls, a disease-associated expression pattern, with higher transcript levels in vitamin D-treated PBMCs from patients, was observed for three of these genes, CLEC5A (P &lt; 0.030), lysozyme (LYZ; P &lt; 0.047) and TREM1 (P &lt; 0.023).	Vitamin D	119-128	lysozyme	Homo sapiens	230-233
29562681-7	2018	Vitamin D supplementation was shown to increase serum 25(OH)D and reduce insulin resistance effectively.	Vitamin D	0-9	insulin	Homo sapiens	73-80
29609719-13	2018	However, further studies are needed to evaluate the causality relationship between vitamin D level and RLS.	Vitamin D	83-92	RLS1	Homo sapiens	103-106
29692809-0	2018	Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People.	Vitamin D	46-55	insulin	Homo sapiens	60-67
29692809-1	2018	Background: The relationship between vitamin D and insulin resistance is still controversial.	Vitamin D	37-46	insulin	Homo sapiens	51-58
29336863-1	2018	The cellular response to 1,25-dihydroxyvitamin D3 (Vit D3; biologically active form of Vitamin D) is complex and depends not only on Vitamin D receptor (VDR) expression but also on cellular uptake of circulating Vit D3 and the presence and activity of Vitamin D-metabolizing enzyme.	Vitamin D	87-96	VDR	Ovis aries	133-151
29330224-0	2018	Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-kappaB-mediated inflammatory genes.	Vitamin D	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-109
29330224-10	2018	Vitamin D supplementation obviously suppressed NF-kappaB pathway activation.	Vitamin D	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	47-56
29330224-11	2018	These results demonstrated that Vitamin D improves impaired wound healing in STZ-induced diabetic mice through suppressing NF-kappaB-mediated inflammatory gene expression.	Vitamin D	32-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
29336863-1	2018	The cellular response to 1,25-dihydroxyvitamin D3 (Vit D3; biologically active form of Vitamin D) is complex and depends not only on Vitamin D receptor (VDR) expression but also on cellular uptake of circulating Vit D3 and the presence and activity of Vitamin D-metabolizing enzyme.	Vitamin D	87-96	VDR	Ovis aries	153-156
29336863-1	2018	The cellular response to 1,25-dihydroxyvitamin D3 (Vit D3; biologically active form of Vitamin D) is complex and depends not only on Vitamin D receptor (VDR) expression but also on cellular uptake of circulating Vit D3 and the presence and activity of Vitamin D-metabolizing enzyme.	Vitamin D	133-142	VDR	Ovis aries	153-156
29290431-6	2018	Immune activation of the intracrine vitamin D pathway, including induction of inducible nitric oxide synthase and beta-defensin gene expression by 1,25(OH)2D3, has been documented in the mammary glands of lactating dairy cows.	Vitamin D	36-45	LOC100296173	Bos taurus	114-127
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	interleukin 4	Homo sapiens	83-87
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	tumor necrosis factor	Homo sapiens	105-114
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	interleukin 4	Homo sapiens	143-147
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	interleukin 6	Homo sapiens	156-160
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	tumor necrosis factor	Homo sapiens	163-172
29449314-6	2018	In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin resistance as well as hyperandrogenism.	Vitamin D	61-70	insulin	Homo sapiens	126-133
30341862-2	2018	Lower level of vitamin D is associated with increased arterial stiffness by activating renin-angiotensin-aldosterone system leading to increased cardiovascular morbidity and mortality including increased risk of coronary artery disease, stroke, peripheral vascular disease, hypertension, diabetes mellitus and metabolic syndrome.	Vitamin D	15-24	renin	Homo sapiens	87-92
29235391-0	2018	Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study.	Vitamin D	20-29	interferon gamma	Homo sapiens	46-62
29235391-6	2018	In vitamin D deficient (i.e., 25(OH)D3&lt;=20 ng/ml) patients, IFNgamma was 150% higher compared with patients with 25(OH)D3&gt;20 ng/ml and controls.	Vitamin D	3-12	interferon gamma	Homo sapiens	63-71
28732679-1	2018	Vitamin D has been reported to have anti-inflammatory properties in in vitro and animal studies, which are thought to occur via inhibition of the nuclear factor kappa-B (NFkappaB) pathway.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	146-168
29520786-1	2018	BACKGROUND: The vitamin D pathway, from toll-like receptor activation to human cationic antimicrobial protein (hCAP-18/LL-37) generation, has been identified in monocytes and keratinocytes.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	111-118
29520786-1	2018	BACKGROUND: The vitamin D pathway, from toll-like receptor activation to human cationic antimicrobial protein (hCAP-18/LL-37) generation, has been identified in monocytes and keratinocytes.	Vitamin D	16-25	cathelicidin antimicrobial peptide	Homo sapiens	119-124
29520786-9	2018	IL-8 and monocyte chemotactic protein-1 mRNA expression could be suppressed by the vitamin D pathway.	Vitamin D	83-92	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28732679-1	2018	Vitamin D has been reported to have anti-inflammatory properties in in vitro and animal studies, which are thought to occur via inhibition of the nuclear factor kappa-B (NFkappaB) pathway.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	170-178
28732679-2	2018	However, the association between vitamin D and in vivo NFkappaB activity in humans has not previously been reported.	Vitamin D	33-42	nuclear factor kappa B subunit 1	Homo sapiens	55-63
28765037-0	2018	Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility.	Vitamin D	0-9	interleukin 6	Homo sapiens	39-42
28732679-11	2018	Although in-vitro studies suggest that vitamin D inhibits NFkappaB activity, our novel cross-sectional data from a cohort of healthy individuals suggest that vitamin D may regulate rather than inhibit the NFkappaB pathway.	Vitamin D	39-48	nuclear factor kappa B subunit 1	Homo sapiens	58-66
28765037-8	2018	We found a downregulation of CCL-2 after vitamin D treatment in IL1beta-stimulated monocytes both from AD patients and HC (AD p&lt;0.001; HC p&lt;0.0001).	Vitamin D	41-50	interleukin 1 beta	Homo sapiens	64-71
28951226-0	2018	Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice.	Vitamin D	26-35	mitogen-activated protein kinase 9	Mus musculus	12-16
28732679-11	2018	Although in-vitro studies suggest that vitamin D inhibits NFkappaB activity, our novel cross-sectional data from a cohort of healthy individuals suggest that vitamin D may regulate rather than inhibit the NFkappaB pathway.	Vitamin D	158-167	nuclear factor kappa B subunit 1	Homo sapiens	205-213
28732679-12	2018	Large-scale intervention and mechanistic studies are needed to further investigate the effects of vitamin D on NFkappaB activity in vivo in humans.	Vitamin D	98-107	nuclear factor kappa B subunit 1	Homo sapiens	111-119
28951226-7	2018	However, JNK2-/- mice, despite vitamin D-deficient diet, had 20-30mmHg lower systolic (SBP) and diastolic (DBP) blood pressure before HFD compared to control mice fed vitamin D-deficient diets, with persistent SBP differences after HFD.	Vitamin D	167-176	mitogen-activated protein kinase 9	Mus musculus	9-13
28951226-8	2018	Moreover, deletion of JNK2 reduced HFD-induced atherosclerosis by 30% in the proximal aorta when compared to control mice fed vitamin D-deficient diets.	Vitamin D	126-135	mitogen-activated protein kinase 9	Mus musculus	22-26
28734987-3	2018	Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues.	Vitamin D	55-64	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
28951226-10	2018	The increased total cellular cholesterol and modified cholesterol uptake in macrophages from mice on vitamin D-deficient HFD were blunted by deletion of JNK2.	Vitamin D	101-110	mitogen-activated protein kinase 9	Mus musculus	153-157
28734987-3	2018	Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues.	Vitamin D	122-131	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
29165650-1	2018	Background: Previous studies showed the role of vitamin D (Vit D) on the progression of chronic urticaria.	Vitamin D	48-57	vitrin	Homo sapiens	59-62
29481024-6	2018	Fifteenpatients (30%) had vitamin D deficiency, which was positively associated with larger tumor size (p &lt; 0.001), highergrade (p = 0.014), advanced stage (p = 0.001), lymph node positivity (p = 0.012), and HER2/neureceptor expression(p = 0.002).	Vitamin D	26-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	211-215
28921422-10	2018	Pre-operative PTH correlated with age, BMI, and vitamin D levels.	Vitamin D	48-57	parathyroid hormone	Homo sapiens	14-17
29681950-6	2018	Moreover, we assayed MSC commitment in the presence of the extracellular matrix (ECM) glycoprotein fibronectin (FN), which is able to favor cell adhesion on surfaces and also to induce osteopontin (OPN) expression: this suggests that Vit D and FN synergize in supporting cell adhesion.	Vitamin D	234-239	fibronectin 1	Homo sapiens	99-110
29481024-9	2018	Conclusion: Vitamin D deficiency had a negative effect on overall anddisease-free survival in our breast cancer cases, being related to tumor size, stage, grade, nodal status and HER2/neureceptor expression.	Vitamin D	12-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	179-183
29456507-5	2018	Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1beta (P = 0.02), tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and interferon gamma (IFN-gamma) (P = 0.03) in PBMCs of diabetic HD patients.	Vitamin D	99-108	interleukin 1 beta	Homo sapiens	158-180
29681950-6	2018	Moreover, we assayed MSC commitment in the presence of the extracellular matrix (ECM) glycoprotein fibronectin (FN), which is able to favor cell adhesion on surfaces and also to induce osteopontin (OPN) expression: this suggests that Vit D and FN synergize in supporting cell adhesion.	Vitamin D	234-239	fibronectin 1	Homo sapiens	112-114
29681950-7	2018	Taken together, our findings provide evidence that Vit D can promote osteogenic differentiation of MSCs through the modulation of alphaVbeta3 integrin expression and its subcellular organization, thus favoring binding with the matrix protein (FN).	Vitamin D	51-56	fibronectin 1	Homo sapiens	243-245
29414925-1	2018	Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites.	Vitamin D	52-61	D-box binding PAR bZIP transcription factor	Homo sapiens	79-82
29401665-4	2018	Interestingly, experimental studies in mice have indicated that vitamin D supplementation significantly lowers renin synthesis and blood pressure.	Vitamin D	64-73	renin	Homo sapiens	111-116
29409465-12	2018	The association of this SNP on survival among CRC patients may differ according to dietary vitamin D and calcium intakes and according to tumor BRAF mutation status.	Vitamin D	91-100	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	144-148
29456507-5	2018	Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1beta (P = 0.02), tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and interferon gamma (IFN-gamma) (P = 0.03) in PBMCs of diabetic HD patients.	Vitamin D	99-108	tumor necrosis factor	Homo sapiens	193-220
29456507-5	2018	Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1beta (P = 0.02), tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and interferon gamma (IFN-gamma) (P = 0.03) in PBMCs of diabetic HD patients.	Vitamin D	99-108	tumor necrosis factor	Homo sapiens	222-231
32153865-0	2018	Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials.	Vitamin D	10-19	C-reactive protein	Homo sapiens	39-57
29456507-5	2018	Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1beta (P = 0.02), tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and interferon gamma (IFN-gamma) (P = 0.03) in PBMCs of diabetic HD patients.	Vitamin D	99-108	interferon gamma	Homo sapiens	248-275
32153865-1	2018	Background: To evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) through a systematic review and meta-analysis of randomized control trials (RCTs).	Vitamin D	38-47	C-reactive protein	Homo sapiens	67-85
32153865-1	2018	Background: To evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) through a systematic review and meta-analysis of randomized control trials (RCTs).	Vitamin D	38-47	C-reactive protein	Homo sapiens	87-90
32153865-2	2018	Methods: PubMed-Medline, SCOPUS, Google Scholar and Web of Science databases were searched (up until April 2016) to identify RCTs evaluating the impact of vitamin D supplementation on CRP.	Vitamin D	155-164	C-reactive protein	Homo sapiens	184-187
32153865-8	2018	Pooling the data together indicated a non-significant decrease in CRP level following administration of vitamin D (weighted mean difference [WMD] -0.26(mg/l), (95% CI -0.75 to 0.22, N = 26 arms, heterogeneity p = 0.042; I2 54.2%).	Vitamin D	104-113	C-reactive protein	Homo sapiens	66-69
32153865-11	2018	Conclusions: This study provided evidence that vitamin D supplementation had no impact on serum CRP, IL10, and TNF-alpha, while significantly increased serum IL6.	Vitamin D	47-56	interleukin 6	Homo sapiens	158-161
29456507-6	2018	Additionally, vitamin D supplementation, compared to the placebo, downregulated gene expression of transforming growth factor beta (TGF-beta) (P = 0.04), protein kinase C (PKC) (P = 0.001), and mitogen-activated protein kinases 1 (MAPK1) (P = 0.02) in PBMCs of diabetic HD patients.	Vitamin D	14-23	transforming growth factor beta 1	Homo sapiens	99-130
29456507-6	2018	Additionally, vitamin D supplementation, compared to the placebo, downregulated gene expression of transforming growth factor beta (TGF-beta) (P = 0.04), protein kinase C (PKC) (P = 0.001), and mitogen-activated protein kinases 1 (MAPK1) (P = 0.02) in PBMCs of diabetic HD patients.	Vitamin D	14-23	transforming growth factor beta 1	Homo sapiens	132-140
29456507-6	2018	Additionally, vitamin D supplementation, compared to the placebo, downregulated gene expression of transforming growth factor beta (TGF-beta) (P = 0.04), protein kinase C (PKC) (P = 0.001), and mitogen-activated protein kinases 1 (MAPK1) (P = 0.02) in PBMCs of diabetic HD patients.	Vitamin D	14-23	mitogen-activated protein kinase 1	Homo sapiens	194-229
29456507-6	2018	Additionally, vitamin D supplementation, compared to the placebo, downregulated gene expression of transforming growth factor beta (TGF-beta) (P = 0.04), protein kinase C (PKC) (P = 0.001), and mitogen-activated protein kinases 1 (MAPK1) (P = 0.02) in PBMCs of diabetic HD patients.	Vitamin D	14-23	mitogen-activated protein kinase 1	Homo sapiens	231-236
29243851-3	2018	Appraisal of the liver revealed an up-regulation of mRNA expressions of the small heterodimer partner (Shp) and attenuation of Cyp7a1, which contributed to hypercholesterolemia in vitamin D-deficiency.	Vitamin D	180-189	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	127-133
29243851-0	2018	Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.	Vitamin D	34-43	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	81-87
29243851-8	2018	In conclusion, vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.	Vitamin D	15-24	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	73-79
29243851-1	2018	The vitamin D-deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D-deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and liver cholesterol, and a reduction in cholesterol 7alpha-hydroxylase (Cyp7a1, rate-limiting enzyme for cholesterol metabolism) and renal Oat3 mRNA/protein expression levels.	Vitamin D	4-13	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	291-321
29243851-1	2018	The vitamin D-deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D-deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and liver cholesterol, and a reduction in cholesterol 7alpha-hydroxylase (Cyp7a1, rate-limiting enzyme for cholesterol metabolism) and renal Oat3 mRNA/protein expression levels.	Vitamin D	4-13	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	323-329
29116467-2	2018	1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, is known to inhibit expression of CYP27B1, which is very similar in structure and function to CYP27A1, the synthesizing enzyme of 27HC.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	108-115
29018141-0	2018	Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.	Vitamin D	0-9	glial cell derived neurotrophic factor	Homo sapiens	24-28
29018141-2	2018	Vitamin D affects dopamine synthesis and metabolism as well as expression of glial cell line-derived neurotrophic factor (GDNF), which is crucial for the survival of dopaminergic neurons.	Vitamin D	0-9	glial cell derived neurotrophic factor	Homo sapiens	77-120
29018141-2	2018	Vitamin D affects dopamine synthesis and metabolism as well as expression of glial cell line-derived neurotrophic factor (GDNF), which is crucial for the survival of dopaminergic neurons.	Vitamin D	0-9	glial cell derived neurotrophic factor	Homo sapiens	122-126
29018141-3	2018	We investigated the role of vitamin D on GDNF and its receptors protooncogene tyrosine-protein kinase receptor Ret (C-Ret) and GDNF family receptor alpha 1 (GFRalpha1) signaling.	Vitamin D	28-37	glial cell derived neurotrophic factor	Homo sapiens	41-45
29498343-13	2018	In conclusion, ethnic origin influenced PTH, PTH response to low vitamin D levels and Ca levels in populations in Greenland.	Vitamin D	65-74	parathyroid hormone	Homo sapiens	45-48
29120677-11	2018	In the subgroup analysis, insulin resistance was found to be determined by sarcopenic rather than vitamin D status.	Vitamin D	98-107	insulin	Homo sapiens	26-33
29018141-9	2018	GDNF was also increased by vitamin D in these cells.	Vitamin D	27-36	glial cell derived neurotrophic factor	Homo sapiens	0-4
29018141-12	2018	These data extend our knowledge of the diverse and important roles played by vitamin D in dopamine physiology.-Pertile, R. A. N., Cui, X., Hammond, L., Eyles, D. W. Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.	Vitamin D	165-174	glial cell derived neurotrophic factor	Homo sapiens	189-193
31038034-7	2018	Meta-analysis on 26 studies with 1789 type 2 diabetic subjects showed that vitamin D significantly reduced systolic blood pressure (SBP; -0.97 mmHg, 95 % CI: -1.94, -0.001, P = 0.050), but not diastolic blood pressure (DBP; -0.10 mmHg, 95 % CI: -0.22, 0.02, P = 0.087).	Vitamin D	75-84	D-box binding PAR bZIP transcription factor	Homo sapiens	219-222
30856079-5	2018	Results: In the group receiving Vitamin D, a significant increase in Calicidiol (15.03 +- 10.44 vs. 27.33 +- 11.2 ng/dl; P = &lt; 0.001), SFRP5 (3.6 +- 0.46 vs. 3.98 +- 0.59 ng/ml; P = 0.01), and Wnt5a (0.33 +- 0.129 vs. 0.29 +- 0.047; P = 0.03) was observed.	Vitamin D	32-41	secreted frizzled related protein 5	Homo sapiens	138-143
28841229-13	2018	The mean difference in hs-CRP was significantly lower in the vitamin D group (P = .045).	Vitamin D	61-70	C-reactive protein	Homo sapiens	26-29
30856079-5	2018	Results: In the group receiving Vitamin D, a significant increase in Calicidiol (15.03 +- 10.44 vs. 27.33 +- 11.2 ng/dl; P = &lt; 0.001), SFRP5 (3.6 +- 0.46 vs. 3.98 +- 0.59 ng/ml; P = 0.01), and Wnt5a (0.33 +- 0.129 vs. 0.29 +- 0.047; P = 0.03) was observed.	Vitamin D	32-41	Wnt family member 5A	Homo sapiens	196-201
29252600-2	2018	The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	31-50
29094433-0	2018	Effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome patients.	Vitamin D	11-20	insulin	Homo sapiens	40-47
29255218-0	2018	Investigating the association of vitamin D with blood pressure and the renin-angiotensin-aldosterone system in hypertensive subjects: a cross-sectional prospective study.	Vitamin D	33-42	renin	Homo sapiens	71-76
29094433-1	2018	AIM: The aim of this study was to identify the effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome (PCOS) patients.	Vitamin D	58-67	insulin	Homo sapiens	87-94
29094433-8	2018	CONCLUSION: Vitamin D supplementation increased insulin sensitivity and decreased androgen levels in vitamin-D-deficient women with PCOS but did not have any effect in vitamin-D-deficient non-PCOS women.	Vitamin D	12-21	insulin	Homo sapiens	48-55
29398866-4	2018	Several studies have assessed the effects of vitamin D supplementation on the sustained virological response (SVR) to interferon (IFN) plus ribavirin (RBV) therapy in HBV and HCV infection.	Vitamin D	45-54	interferon alpha 1	Homo sapiens	130-133
29465564-2	2018	To date, no attempts have been made to examine the correlation between the incidence of caries and the concentrations of vitamin D in children with pituitary growth hormone deficiency.The study observed patients of the Department of Endocrinology and Diabetology of the University Paediatric Hospital of the Medical University of Lublin treated with human recombinant growth hormone for pituitary growth hormone deficiency (GHD).	Vitamin D	121-130	growth hormone 1	Homo sapiens	158-172
29465575-4	2018	Hepatic fibrosis was assessed using Fib-4 and Forns index.Eighty-two (54.40%) patients demonstrated deficiency of vitamin D and this was associated to AST (P = .019 [CI: 1.003-1.034]), total cholesterol (P = .038 [CI: 1.004-1.164]), fibrosis grade (P &lt; .001 [CI: 0.000-0.844]), and FokI (P = .028) allele T presence.	Vitamin D	114-123	solute carrier family 17 member 5	Homo sapiens	151-154
29257249-0	2018	Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NF-kappaB signaling pathway.	Vitamin D	0-9	toll-like receptor 4	Mus musculus	72-76
28778809-1	2018	AIMS: Vitamin D is associated with diabetes mellitus (DM) occurrence by affecting insulin secretion and resistance.	Vitamin D	6-15	insulin	Homo sapiens	82-89
29235392-3	2018	In this study, we aimed to gain a better understanding of the risk factors for osteoporosis and vitamin D deficiency in the era of TNF-alpha inhibitors.	Vitamin D	96-105	tumor necrosis factor	Homo sapiens	131-140
29235392-6	2018	RESULTS: CD patients treated with TNF-alpha inhibitors (TNF) and those who are anti-TNF naive (NB) had similar rates of vitamin D deficiency, insufficiency and normal vitamin D-25-OH levels.	Vitamin D	120-129	tumor necrosis factor	Homo sapiens	56-59
29368588-1	2018	BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1).	Vitamin D	61-70	growth hormone 1	Homo sapiens	82-96
29368588-1	2018	BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1).	Vitamin D	61-70	growth hormone 1	Homo sapiens	98-100
29368588-1	2018	BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1).	Vitamin D	61-70	insulin like growth factor 1	Homo sapiens	106-134
29368588-1	2018	BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1).	Vitamin D	61-70	insulin like growth factor 1	Homo sapiens	136-140
29357898-10	2018	The maternal and neonatal vitamin D concentrations were negatively correlated with their DBP concentrations (P = 0.048 and P = 0.002, respectively).	Vitamin D	26-35	D-box binding PAR bZIP transcription factor	Homo sapiens	89-92
29357898-11	2018	CONCLUSION: High maternal and neonatal DBP levels may lead to an incorrect low estimate of the true Vitamin D concentration.	Vitamin D	100-109	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
29357898-1	2018	BACKGROUND: To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60.	Vitamin D	81-90	D-box binding PAR bZIP transcription factor	Homo sapiens	134-137
29342166-12	2018	Consistently, a significantly decreased activation of the SCAP/SREBP lipogenic pathway and lower levels of CML protein adducts and RAGE expression were observed in skeletal muscle of animals treated with vitamin D.	Vitamin D	204-213	MOK protein kinase	Mus musculus	131-135
29357898-1	2018	BACKGROUND: To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60.	Vitamin D	92-101	D-box binding PAR bZIP transcription factor	Homo sapiens	134-137
29351340-7	2018	HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice.	Vitamin D	8-17	interleukin 6	Mus musculus	38-42
29342166-13	2018	Collectively, these data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-kappaB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements.	Vitamin D	39-48	MOK protein kinase	Mus musculus	141-145
29338758-12	2018	Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with saliva LL37 levels.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	109-113
29350657-9	2018	Calcium and vitamin D metabolites are currently the cornerstone of therapy in HPT.	Vitamin D	12-21	HPT	Homo sapiens	78-81
29350657-13	2018	HPT requires lifelong therapy with vitamin D or metabolites and is often associated with complications and comorbidities.Therefore, it is important for endocrinologists and other physicians, who care for these patients, to be aware of recent advances of this disorder.	Vitamin D	35-44	HPT	Homo sapiens	0-3
29338758-14	2018	Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with LL37 expression.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	102-106
29649340-1	2018	The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained.	Vitamin D	109-118	growth hormone 1	Homo sapiens	45-59
29342981-2	2018	Obese children are at risk of developing vitamin D deficiency, which appears to have negative influences on energy homeostasis, impeded bone mineralisation, insulin resistance and inflammation.	Vitamin D	41-50	insulin	Homo sapiens	157-164
29320465-0	2018	CRP Genotypes Predict Increased Risk to Co-Present with Low Vitamin D and Elevated CRP in a Group of Healthy Black South African Women.	Vitamin D	60-69	C-reactive protein	Homo sapiens	0-3
29348609-7	2018	In meta-analyses, vitamin D-supplemented groups had lower concentrations of tumor necrosis factor-alpha (TNF-alpha) at follow-up compared with controls (n = 380; p = 0.04).	Vitamin D	18-27	tumor necrosis factor	Homo sapiens	76-103
29348609-7	2018	In meta-analyses, vitamin D-supplemented groups had lower concentrations of tumor necrosis factor-alpha (TNF-alpha) at follow-up compared with controls (n = 380; p = 0.04).	Vitamin D	18-27	tumor necrosis factor	Homo sapiens	105-114
29375203-12	2018	Treatment of re-cultured PSCs with Dvitamins was associated with lower expression of IL-6 (-42% to -49%; P &lt; 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene (209%-321% vs controls; P &lt; 0.05).	Vitamin D	35-44	interleukin 6	Mus musculus	85-89
29484258-9	2018	Results: Serum vitamin D levels were negatively correlated with serum levels of interleukin-6 and high-sensitivity C-reactive protein (hsCRP) (r = -.244, p = .002; r = -.231, p = .004).	Vitamin D	15-24	interleukin 6	Homo sapiens	80-93
29484258-10	2018	Multiple regression analysis showed that interleukin-6 and hsCRP levels were associated with vitamin D levels (B = -0.355, p = .003; B = -2.085, p = .006), whereas age, height, weight, leukocyte count, neutrophil ratio, and lymphocyte rate could be omitted without changing the results.	Vitamin D	93-102	interleukin 6	Homo sapiens	41-54
29484258-12	2018	Conclusions: Serum vitamin D levels are inversely associated with the levels of interleukin-6 and hsCRP, suggesting a potential anti-inflammatory role for vitamin D in stroke individuals.	Vitamin D	19-28	interleukin 6	Homo sapiens	80-93
31149239-13	2018	Conclusions: Vitamin D status in conjunction with other parameters - such as T2DM - or serum biomarkers - namely fibrinogen level and PCR level - may point out the aggressive forms of NAFLD and the need for liver biopsy for appropriate management.	Vitamin D	13-22	fibrinogen beta chain	Homo sapiens	113-123
29649340-1	2018	The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained.	Vitamin D	109-118	insulin like growth factor 1	Homo sapiens	93-98
29945132-3	2018	METHODS: We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Vitamin D	166-175	C-reactive protein	Homo sapiens	212-230
28936809-0	2018	Association Between Vitamin D and Carboxy-Terminal Cross-Linked Telopeptide of Type I Collagen in Children During Growth Hormone Replacement Therapy.	Vitamin D	20-29	growth hormone 1	Homo sapiens	114-128
29258108-0	2018	Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults.	Vitamin D	0-9	PPARG coactivator 1 alpha	Homo sapiens	100-168
29258108-3	2018	The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) gene expression.	Vitamin D	65-74	PPARG coactivator 1 alpha	Homo sapiens	142-210
29258108-3	2018	The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) gene expression.	Vitamin D	65-74	PPARG coactivator 1 alpha	Homo sapiens	212-222
29258108-10	2018	Linear regression analysis used to show the mediatory role of VDR and PGC-1alpha on the RMR/kg body weight and vitamin D status relationship.	Vitamin D	111-120	PPARG coactivator 1 alpha	Homo sapiens	70-80
30260797-0	2018	Tenofovir disoproxil fumarate appears to disrupt the relationship of vitamin D and parathyroid hormone.	Vitamin D	69-78	parathyroid hormone	Homo sapiens	83-102
29108830-0	2018	Vitamin D and systemic lupus erythematosus - The hype and the hope.	Vitamin D	0-9	FIC domain protein adenylyltransferase	Homo sapiens	49-53
29283046-3	2018	Vitamin D is involved in the clearance of beta-amyloid (Abeta) from the brain.	Vitamin D	0-9	amyloid beta precursor protein	Homo sapiens	56-61
29424911-6	2018	High dose vitamin D and omega 3 could be of assistance in childhood T1D therapy, to prolong preservation of endogenous insulin secretion in the absence of side effects.	Vitamin D	10-19	insulin	Homo sapiens	119-126
28958110-1	2018	The current study was conducted to assess the effects of vitamin D supplementation on insulin metabolism, lipid fractions, biomarkers of inflammation, and oxidative stress in diabetic hemodialysis (HD) patients.	Vitamin D	57-66	insulin	Homo sapiens	86-93
28958110-7	2018	Overall, we found that vitamin D supplementation had beneficial effects on serum insulin, HOMA-IR, QUICKI, serum hs-CRP, plasma MDA, and TAC levels among diabetic HD patients for 12 weeks.	Vitamin D	23-32	insulin	Homo sapiens	81-88
29131543-9	2018	In addition, HLA-DRB1*15:01 and HLA-DQB1*06:02 were found to be associated with lower vitamin D levels.	Vitamin D	86-95	major histocompatibility complex, class II, DR beta 1	Homo sapiens	13-21
29515300-0	2018	Factors Affecting Insulin Resistance and Its Relation to Vitamin D Status and Clinical Nutritional Parameters in Dialysis Patients: A Single-center Indian Study.	Vitamin D	57-66	insulin	Homo sapiens	18-25
29515300-1	2018	The aim of this study was to measure insulin resistance (IR) in dialysis patients and its relation to Vitamin D status and nutritional parameters.	Vitamin D	102-111	insulin	Homo sapiens	37-44
28891071-10	2018	Interestingly, TYRP1 might be related to breast cancer through a non-vitamin D relevant mechanism but further studies are needed.	Vitamin D	69-78	tyrosinase related protein 1	Homo sapiens	15-20
29238429-4	2018	The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH).	Vitamin D	59-68	parathyroid hormone	Homo sapiens	225-244
29238429-4	2018	The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH).	Vitamin D	59-68	parathyroid hormone	Homo sapiens	246-249
29238429-15	2018	Conclusions: This study suggested that vitamin D and low-fat milk supplementation improves bone metabolism by sustaining the 25(OH)D concentration and decreasing the PTH concentration in female high-school endurance runners regardless of the state of menses.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	166-169
29232067-8	2018	But CD patients benefited from therapy with tumor necrosis factor-alpha inhibitor and exhibited significantly higher vitamin D levels than those without.	Vitamin D	117-126	tumor necrosis factor	Homo sapiens	44-71
29710028-4	2018	The protein expressions of markers linked with the vitamin D action were altered by VDD (vitamin D receptor VDR, 25-hydroxyvitamin D-24-hydroxylase CYP24A1, CYP27B1, and CYP2R1).	Vitamin D	51-60	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	157-164
29962427-11	2018	This study indicates the association of vitamin D with insulin resistance in male patients with newly diagnosed T2DM, which may contribute to the understanding of the mechanism underlying the onset of T2DM in the Chinese Han population.	Vitamin D	40-49	insulin	Homo sapiens	55-62
27662816-0	2018	Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome.	Vitamin D	16-25	insulin	Homo sapiens	31-38
27662816-1	2018	The aim of this study is to determine the relationships of vitamin D with diabetes, insulin resistance obesity, and metabolic syndrome.	Vitamin D	59-68	insulin	Homo sapiens	84-91
27662816-6	2018	In addition to the well-studied musculoskeletal effects, vitamin D decreases the insulin resistance, severity of T2D, prediabetes, metabolic syndrome, inflammation, and autoimmunity.	Vitamin D	57-66	insulin	Homo sapiens	81-88
27818276-3	2018	Recent evidence shows that vitamin D acts to maintain the integrity of the gut mucosal barrier by enhancement of intercellular junctions that control mucosal permeability and reduction of pro-inflammatory cytokines such as IL-8.	Vitamin D	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
28027916-5	2018	Vitamin D deficiency in KSA has been mostly associated with bone and insulin-resistant diseases but limited data are available to prove causality.	Vitamin D	0-9	insulin	Homo sapiens	69-76
28161533-6	2018	Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays.	Vitamin D	70-79	D-box binding PAR bZIP transcription factor	Homo sapiens	89-92
29409597-9	2018	After adjustment for genetic ancestry, sex, age, vitamin D level, DMT use and HLA-DRB1*15 status, having two copies of the MS risk allele within AHI1 (rs11154801) was associated with increased relapses among children (HR = 1.75,95%CI = 1.18-2.48, p = 0.006) and this result was also observed among adults (HR = 1.81,95%CI = 1.05-3.03, p = 0.026).	Vitamin D	49-58	Abelson helper integration site 1	Homo sapiens	145-149
30300431-9	2018	Vitamin D has an effect on bone remodeling through its receptor and its polymorphisms: Apa1, Bsm1, Taq1, Fok1 and Cdx2.	Vitamin D	0-9	zinc finger protein 410	Homo sapiens	87-91
29281967-10	2017	Vitamin D administrations reduced IL-1beta, NF-Kbeta and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group.	Vitamin D	0-9	interleukin 1 beta	Rattus norvegicus	34-42
29299028-9	2017	Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant.	Vitamin D	68-77	transforming growth factor beta 1	Homo sapiens	138-143
29298969-14	2017	An important role in supporting NAFLD treatment is also attributed to vitamin D, C and E supplementation and some probiotic bacteria, as well as cinnamon and turmeric, which improve insulin sensitivity.	Vitamin D	70-79	insulin	Homo sapiens	182-189
29079468-0	2017	Addition of vitamin D reverses the decline in GFR following treatment with ACE inhibitors/angiotensin receptor blockers in patients with chronic kidney disease.	Vitamin D	12-21	angiotensin I converting enzyme	Homo sapiens	75-78
30080325-2	2018	A deficiency of vitamin D was significantly more prevalent in COPD patients with GFRcys &lt;60 ml/min/1,73 m2 compared to patients with preserved renal function.	Vitamin D	16-25	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
29159450-5	2018	Transcripts associated with vitamin D hydroxylation (Cyp24A1, Cyp27A1, Cyp27B1) were regulated by diet at local tissue sites.	Vitamin D	28-37	cytochrome P450 family 24 subfamily A member 1	Sus scrofa	53-60
29466786-6	2018	Vitamin D supplementation significantly decreased fasting plasma glucose (-7.8 +- 9.2 vs. -1.1 +- 8.6 mg/dL, p = 0.006) and insulin levels (-3.2 +- 4.8 vs. -0.9 +- 3.4 microIU/mL, p = 0.03), and significantly increased quantitative insulin sensitivity check index (0.01 +- 0.02 vs. 0.002 +- 0.01, p = 0.02) compared with the placebo.	Vitamin D	0-9	insulin	Homo sapiens	124-131
29466786-6	2018	Vitamin D supplementation significantly decreased fasting plasma glucose (-7.8 +- 9.2 vs. -1.1 +- 8.6 mg/dL, p = 0.006) and insulin levels (-3.2 +- 4.8 vs. -0.9 +- 3.4 microIU/mL, p = 0.03), and significantly increased quantitative insulin sensitivity check index (0.01 +- 0.02 vs. 0.002 +- 0.01, p = 0.02) compared with the placebo.	Vitamin D	0-9	insulin	Homo sapiens	232-239
29950548-7	2018	However, recent meta-analyses of randomized controlled trials in which large doses vitamin D over 2,000 IU/day supplemented to type 2 diabetes patients revealed a small but significant improvement in indices of insulin resistance and glycemic control.	Vitamin D	83-92	insulin	Homo sapiens	211-218
28618984-0	2018	Glycemic Variability and Insulin Needs in Patients with Type 1 Diabetes Mellitus Supplemented with Vitamin D: A Pilot Study Using Continuous Glucose Monitoring System.	Vitamin D	99-108	insulin	Homo sapiens	25-32
29701163-0	2018	Vitamin D status in coronary artery disease: association with IL-35 and TGF-beta1 and disease severity.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	72-81
29701163-8	2018	Both TGF-beta1 and IL-35 were positively correlated to the serum level of vitamin D (r= 0.38, p= 0.001 and r=0.26, p= 0.028 respectively).	Vitamin D	74-83	transforming growth factor beta 1	Homo sapiens	5-14
29701163-10	2018	Compared to normal serum vitamin D patients (326.6+-351.7 pg/mL vs. 754.5+-560 pg/mL, p=0.036 respectively) TGF-beta1 (but not IL-35), was significantly lower in vitamin D deficient patients.	Vitamin D	162-171	transforming growth factor beta 1	Homo sapiens	108-117
29701163-11	2018	CONCLUSION: The results suggested that, although decreased TGF-beta1 and IL-35 plasma levels correlate positively with decreased vitamin D levels and negatively with severity of CAD, but only TGF-beta1 has a significant association with vitamin D deficiency in CAD patients.	Vitamin D	237-246	transforming growth factor beta 1	Homo sapiens	192-201
29701163-12	2018	It seems that the antiatherosclerotic effect of vitamin D is at least partly attributed to the up-regulation of anti-inflammatory cytokines especially TGF- beta1.	Vitamin D	48-57	transforming growth factor beta 1	Homo sapiens	151-161
29597231-0	2018	Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis.	Vitamin D	46-55	parathyroid hormone	Homo sapiens	26-45
29597233-7	2018	The free concentration may be a more accurate indicator of vitamin D status especially in individuals with DBP levels that deviate from the normal population.	Vitamin D	59-68	D-box binding PAR bZIP transcription factor	Homo sapiens	107-110
29297432-2	2018	Some of the beneficial effects of vitamin D might be mediated through interleukin-1beta (IL-1beta).	Vitamin D	34-43	interleukin 1 beta	Homo sapiens	70-87
29297432-2	2018	Some of the beneficial effects of vitamin D might be mediated through interleukin-1beta (IL-1beta).	Vitamin D	34-43	interleukin 1 beta	Homo sapiens	89-97
29371756-4	2018	In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group.	Vitamin D	30-39	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	111-118
29653812-6	2018	Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P &lt; .05 for all).	Vitamin D	0-9	apolipoprotein B	Homo sapiens	226-242
29653812-6	2018	Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P &lt; .05 for all).	Vitamin D	0-9	apolipoprotein B	Homo sapiens	244-248
29653812-6	2018	Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P &lt; .05 for all).	Vitamin D	0-9	apolipoprotein B	Homo sapiens	255-259
29653812-6	2018	Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P &lt; .05 for all).	Vitamin D	0-9	apolipoprotein E	Homo sapiens	297-301
30379301-9	2018	Vitamin D insufficiency was estimated by compensatory elevations of PTH above the normal range (&gt; 65 pg/mL).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	68-71
30379314-2	2018	Since age affect insulin sensitivity and the metabolism, we aimed in this randomized controlled trial to investigate the effect of vitamin D supplementation on glucose homeostasis and index of insulin resistance in elderly subjects living in Beirut, Lebanon.	Vitamin D	131-140	insulin	Homo sapiens	17-24
30379314-2	2018	Since age affect insulin sensitivity and the metabolism, we aimed in this randomized controlled trial to investigate the effect of vitamin D supplementation on glucose homeostasis and index of insulin resistance in elderly subjects living in Beirut, Lebanon.	Vitamin D	131-140	insulin	Homo sapiens	193-200
30379314-6	2018	RESULTS: Vitamin D supplementation led to significant improvements in blood levels of [25(OH) D] (P&lt; 0.0001), and a significant decreased of HOMA, PTH and FBG concentrations (P&lt; 0.0001) in the intervention group compared to placebo.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	150-153
29386413-0	2018	Effect of Vitamin D therapy on urinary albumin excretion, renal functions, and plasma renin among patients with diabetic nephropathy: A randomized, double-blind clinical trial.	Vitamin D	10-19	albumin	Homo sapiens	39-46
29386413-0	2018	Effect of Vitamin D therapy on urinary albumin excretion, renal functions, and plasma renin among patients with diabetic nephropathy: A randomized, double-blind clinical trial.	Vitamin D	10-19	renin	Homo sapiens	86-91
29386413-13	2018	CONCLUSIONS: Vitamin D 50000 IU given IM monthly for 6 months reduces urine albumin, serum creatinine, and renin levels in patients with DN.	Vitamin D	13-22	albumin	Homo sapiens	76-83
29386413-13	2018	CONCLUSIONS: Vitamin D 50000 IU given IM monthly for 6 months reduces urine albumin, serum creatinine, and renin levels in patients with DN.	Vitamin D	13-22	renin	Homo sapiens	107-112
29562806-1	2018	BACKGROUND: Prior studies suggest that vitamin D therapy may decrease cardiovascular disease risk in type 2 diabetes (T2DM) by lowering renin-angiotensin system (RAS) activity.	Vitamin D	39-48	renin	Homo sapiens	136-141
29169581-11	2018	At baseline, those with vitamin D&gt;25nmol/L performed better on verbal fluency (beta=2.46, 95%CI=0.53,4.40) and TMT-B time (beta=-18.23, 95%CI=-32.86,-3.61), with higher executive function (beta=1.40, 95%CI=0.44,2.37).	Vitamin D	24-33	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	192-198
27966076-7	2018	However, vitamin D metabolism encoding genes of CYP27B1 and CYP24A1 and predicting MS risk gene of HLA-DRB1*15:01 define its fate as well.	Vitamin D	9-18	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	48-55
27966076-7	2018	However, vitamin D metabolism encoding genes of CYP27B1 and CYP24A1 and predicting MS risk gene of HLA-DRB1*15:01 define its fate as well.	Vitamin D	9-18	major histocompatibility complex, class II, DR beta 1	Homo sapiens	99-107
27966076-8	2018	Besides, vitamin D intake, through the proliferation decrement of pro-inflammatory cells, decreases of pro-inflammatory markers (IL-6, TNF-alpha, INF-gamma) and auto-immune pathways have potential role in recovery of irregular menstruation in women with the low level of testosterone as a red warning factor of MS development.	Vitamin D	9-18	interleukin 6	Homo sapiens	129-133
27966076-8	2018	Besides, vitamin D intake, through the proliferation decrement of pro-inflammatory cells, decreases of pro-inflammatory markers (IL-6, TNF-alpha, INF-gamma) and auto-immune pathways have potential role in recovery of irregular menstruation in women with the low level of testosterone as a red warning factor of MS development.	Vitamin D	9-18	tumor necrosis factor	Homo sapiens	135-144
32476902-15	2018	However, some statistically significant changes in serum vitamin D and PTH levels were demonstrated that were consistent with some amelioration of sarcoidosis-induced vitamin D dysregulation.	Vitamin D	167-176	parathyroid hormone	Homo sapiens	71-74
29024812-6	2017	Mutation analysis confirmed the presence and functionality of a vitamin D response element in the PC gene promoter region.	Vitamin D	64-73	pyruvate carboxylase	Homo sapiens	98-100
29255137-3	2017	The optimal vitamin D level was determined according to the suppression of parathyroid hormone (PTH) and the highest bone mineral density (BMD).	Vitamin D	12-21	parathyroid hormone	Homo sapiens	75-94
29945132-3	2018	METHODS: We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Vitamin D	166-175	tumor necrosis factor	Homo sapiens	241-268
29945132-6	2018	The results indicated that the vitamin D supplementation significant decreased the hs-CRP level by 0.45 mug/mL, whereas the vitamin D supplementation did not  influence the TNF-alpha and IL-6.	Vitamin D	31-40	C-reactive protein	Homo sapiens	86-89
29945132-7	2018	Subgroup analysis showed that vitamin D significantly lowered hs-CRP by 0.34 mug/mL among trials with a daily vitamin D dose <=4,000 IU and by 0.31 mug/mL among trials with time of vitamin D supplementation > 12 weeks.	Vitamin D	30-39	C-reactive protein	Homo sapiens	65-68
29945132-8	2018	CONCLUSIONS: Vitamin D supplementation is beneficial for the reduction of hs-CRP inT2DM subjects but does not have a significant influence on TNF-alpha and IL-6 in T2DM subjects.	Vitamin D	13-22	C-reactive protein	Homo sapiens	77-80
29208972-1	2017	This study investigated the effects of 1,25(OH)2D3 and 24R,25(OH)2D3 on corneal epithelial cell proliferation, migration, and on the vitamin D activating enzyme CYP27B1 (produces 1,25(OH)2D3) and inactivating enzyme CYP24A1 (produces 24R,25(OH)2D3).	Vitamin D	133-142	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	161-168
28606441-8	2017	Vitamin D therapy significantly reduced DBP, total cholesterol and LDL but the between group differences were not significant.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	40-43
28815553-10	2017	Prevalence of vitamin D deficiency was 50% (defined as a 25-OH vitamin D level &lt; 50 nmol L-1 ).	Vitamin D	14-23	immunoglobulin kappa variable 1-16	Homo sapiens	92-95
29080642-2	2017	For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)2D and 0.03% for 25(OH)D) is free, with more than 99% bound to the vitamin D binding protein (DBP) and albumin (approximately 85% and 15%, respectively).	Vitamin D	8-17	D-box binding PAR bZIP transcription factor	Homo sapiens	155-158
29080642-3	2017	Assays to measure the free vitamin D metabolite levels have been developed, and initial studies indicated their value in subjects with altered DBP levels.	Vitamin D	27-36	D-box binding PAR bZIP transcription factor	Homo sapiens	143-146
28589382-3	2017	We analyzed gene and protein expression of VDR and PR and gene expression of vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzymes in follicular cancer cells and the adjacent non-neoplastic thyroid tissue (NNTT).	Vitamin D	77-86	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	164-171
29029014-2	2017	In this study, we explored the relevance of vitamin D modulation of GLUL and other metabolic genes in the context of glutamine utilization and dependence.	Vitamin D	44-53	glutamate-ammonia ligase	Homo sapiens	68-72
28425575-0	2017	High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C-Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution.	Vitamin D	29-38	C-reactive protein	Homo sapiens	113-131
28425575-3	2017	The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C-Reactive Protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls.	Vitamin D	59-68	C-reactive protein	Homo sapiens	94-112
28425575-3	2017	The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C-Reactive Protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls.	Vitamin D	59-68	C-reactive protein	Homo sapiens	114-117
28425575-8	2017	Interestingly we observed a significant reduction in neutrophil count and CRP level after high dose vitamin D supplementation.	Vitamin D	100-109	C-reactive protein	Homo sapiens	74-77
28425575-9	2017	Our findings showed that the high dose supplementation of vitamin D affects measures of systemic inflammation: reductions in High Sensitivity C-Reactive Protein level and Neutrophil-to-lymphocyte ratio (NLR) distribution.	Vitamin D	58-67	C-reactive protein	Homo sapiens	142-160
29271617-8	2017	Serum sclerostin concentrations transiently increased at week 4 in the vitamin D group.	Vitamin D	71-80	sclerostin	Homo sapiens	6-16
28616825-6	2017	Fasting glucose and insulin levels were significantly higher in subjects with vitamin D deficiency/insufficiency (P = 0.034 and P = 0.049, respectively) as well as HOMA-IR (P = 0.05).	Vitamin D	78-87	insulin	Homo sapiens	20-27
28616825-9	2017	At univariate regression analysis, the parameters that were significantly associated with vitamin D levels were insulin (P = 0.050), HDL cholesterol (P = 0.016), and intima-media thickness (P = 0.015).	Vitamin D	90-99	insulin	Homo sapiens	112-119
28418012-0	2017	CYP3A4 is a crosslink between vitamin D and calcineurin inhibitors in solid organ transplant recipients: implications for bone health.	Vitamin D	30-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
28418012-5	2017	We also provide an overview of the literature on the interplay between vitamin D metabolism and CYP3A4 in experimental and clinical settings and discuss its possible implications for solid organ transplant recipients.	Vitamin D	71-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-102
28418012-6	2017	In conclusion, there is a body of evidence on the interplay between vitamin D and the drug-metabolizing enzyme CYP3A4, which may have therapeutic implications.	Vitamin D	68-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117
29176783-1	2017	BACKGROUND: Previous reports about the relationship between a high parathyroid hormone (PTH) and low vitamin D levels with blood pressure in different hypertension groups are conflicting.	Vitamin D	101-110	parathyroid hormone	Homo sapiens	67-86
29160418-12	2017	Vitamin D levels correlated negatively with body weight, lung resistance levels at 25 mg/mL of methacholine, total inflammatory cells, and IL-1beta and IL-17 concentrations in BALF.	Vitamin D	0-9	interleukin 1 beta	Mus musculus	139-147
29186865-7	2017	Vitamin D could restore cell viability, and inflammatory and oxidative status, as shown by cell metabolic activity, interleukin-6 (IL-6) levels and reactive oxygen species (ROS) production, respectively.	Vitamin D	0-9	interleukin 6	Homo sapiens	116-129
29186865-7	2017	Vitamin D could restore cell viability, and inflammatory and oxidative status, as shown by cell metabolic activity, interleukin-6 (IL-6) levels and reactive oxygen species (ROS) production, respectively.	Vitamin D	0-9	interleukin 6	Homo sapiens	131-135
29186759-0	2017	Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.	Vitamin D	33-42	insulin	Homo sapiens	84-91
29186759-1	2017	This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS).	Vitamin D	54-63	insulin	Homo sapiens	109-116
29186759-6	2017	Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.	Vitamin D	19-28	insulin	Homo sapiens	60-67
29186759-6	2017	Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.	Vitamin D	19-28	sex hormone binding globulin	Homo sapiens	140-144
29123173-0	2017	Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial.	Vitamin D	10-19	nuclear factor kappa B subunit 1	Homo sapiens	56-78
29123173-1	2017	In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFkappaB) activity.	Vitamin D	30-39	nuclear factor kappa B subunit 1	Homo sapiens	75-97
29123173-1	2017	In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFkappaB) activity.	Vitamin D	30-39	nuclear factor kappa B subunit 1	Homo sapiens	99-107
29123173-2	2017	Yet, no trials have examined the effects of vitamin D supplementation on NFkappaB activity in-vivo in humans.	Vitamin D	44-53	nuclear factor kappa B subunit 1	Homo sapiens	73-81
29123173-3	2017	We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NFkappaB activity in peripheral blood mononuclear cells (PBMCs).	Vitamin D	72-81	nuclear factor kappa B subunit 1	Homo sapiens	126-134
27030935-4	2017	In type 2 diabetes, vitamin D may influence beta-cell function, insulin sensitivity, and systematic inflammation-all characteristic pathways of that disease.	Vitamin D	20-29	insulin	Homo sapiens	64-71
28922720-6	2017	To our knowledge, this is the first to use 1-alpha-hydroxylase [1alpha(OH)ase] knockout mice which characterized vitamin D deficiency to establish the breast cancer bone metastases model.	Vitamin D	113-122	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	64-77
29285447-0	2017	Role of Parathyroid Hormone in Determination of Fat Mass in Patients with Vitamin D Deficiency.	Vitamin D	74-83	parathyroid hormone	Homo sapiens	8-27
28403520-10	2017	In addition, lower expression of CYP27B1 in patients with AGA supports the notion that changes in vitamin D metabolism contributes to hair loss.	Vitamin D	98-107	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	33-40
28938443-6	2017	Vitamin D deficiency further exaggerated colonic Cyp27b1 induction and aggravated colonic inflammation in mice.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	49-56
28703134-1	2017	Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor.	Vitamin D	55-64	transforming growth factor beta 1	Homo sapiens	125-134
28669880-0	2017	Role of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer"s disease: A potential therapeutic target?	Vitamin D	8-17	LDL receptor related protein 1	Homo sapiens	43-48
28669880-9	2017	The present review establishes a strong correlation between Vitamin D and LRP-1 and their possible involvement in Abeta clearance and thereby emerging as new therapeutic target.	Vitamin D	60-69	LDL receptor related protein 1	Homo sapiens	74-79
28669880-9	2017	The present review establishes a strong correlation between Vitamin D and LRP-1 and their possible involvement in Abeta clearance and thereby emerging as new therapeutic target.	Vitamin D	60-69	amyloid beta precursor protein	Homo sapiens	114-119
28703134-1	2017	Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	125-134
28945992-0	2017	Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control.	Vitamin D	60-69	microRNA 192	Homo sapiens	41-48
28945992-9	2017	In conclusion, reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes.	Vitamin D	140-149	microRNA 192	Homo sapiens	50-57
28945992-5	2017	Circulating levels of miR-7 (sixfold reduction, P=.01), miR-152 (1.5-fold increase, P=.03), and miR-192 (1.7-fold reduction, P=.026) displayed significant treatment-by-time interactions between the placebo- and the vitamin-D-treated groups.	Vitamin D	215-224	microRNA 192	Homo sapiens	96-103
27282116-8	2017	The differential vitamin D responsiveness of the VitDbol study participants was determined via individual changes in their PTH levels or chromatin accessibility in relation to alterations in 25(OH)D3 concentrations.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	123-126
28741856-0	2017	Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin.	Vitamin D	21-30	adiponectin, C1Q and collagen domain containing	Homo sapiens	113-124
28941306-12	2017	CONCLUSIONS AND CLINICAL IMPORTANCE: Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations.	Vitamin D	95-104	calcium voltage-gated channel subunit alpha1 C	Canis lupus familiaris	144-147
28926770-8	2017	Here we showed that Vitamin D could significantly upregulate PLC-gamma1 expression, which then induced expression of TGF-beta1.	Vitamin D	20-29	phospholipase C gamma 1	Homo sapiens	61-71
28926770-8	2017	Here we showed that Vitamin D could significantly upregulate PLC-gamma1 expression, which then induced expression of TGF-beta1.	Vitamin D	20-29	transforming growth factor beta 1	Homo sapiens	117-126
28944831-0	2017	Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system.	Vitamin D	0-9	renin	Homo sapiens	88-93
29087955-6	2017	Conversely, HER2 has certain effects in normal conditions such as differentiation of preadipocytes, cardiovascular health and vitamin D metabolism.	Vitamin D	126-135	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-16
28829285-0	2017	Vitamin D insufficiency/deficiency is associated with insulin resistance in Brazilian children, regardless of body fat distribution.	Vitamin D	0-9	insulin	Homo sapiens	54-61
28665452-2	2017	The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients.	Vitamin D	134-143	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	103-110
28665452-11	2017	The mean serum levels of active vitamin D were higher among patients with polymorphic genotype variants of Apa1 or Bsm1.	Vitamin D	32-41	zinc finger protein 410	Homo sapiens	107-111
29088291-2	2017	Vitamin D is activated by 25-hydroxylase (CYP2R1) and 1-alpha-hydroxylase (CYP27B1) and is degraded by 24-hydroxylase (CYP24A1).	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Sus scrofa	119-126
29088221-1	2017	BACKGROUND: Although previous studies reported an association between serum vitamin D and parathyroid hormone (PTH) with carotid atherosclerosis or arterial stiffness, these were inconsistent.	Vitamin D	76-85	parathyroid hormone	Homo sapiens	90-109
29088291-3	2017	Vitamin D is transported by vitamin D-binding protein (group-specific component, GC) through the bloodstream and regulates cellular actions by binding to vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Sus scrofa	154-172
29088221-1	2017	BACKGROUND: Although previous studies reported an association between serum vitamin D and parathyroid hormone (PTH) with carotid atherosclerosis or arterial stiffness, these were inconsistent.	Vitamin D	76-85	parathyroid hormone	Homo sapiens	111-114
29084522-1	2017	BACKGROUND: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	126-145
29088291-3	2017	Vitamin D is transported by vitamin D-binding protein (group-specific component, GC) through the bloodstream and regulates cellular actions by binding to vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Sus scrofa	174-177
29084522-1	2017	BACKGROUND: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	147-150
29088291-5	2017	Vitamin D-metabolizing enzymes CYP2R1, CYP27B1, and CYP24A1, vitamin D binding protein GC, and vitamin D receptor VDR were expressed in the endometrium in a pregnancy stage-specific manner as well as in conceptus and chorioallantoic tissues during pregnancy.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Sus scrofa	52-59
28902630-4	2017	At 6 years an elevated PTH was detected with normal calcium and a low 25(OH) vitamin D level (25OHD).	Vitamin D	77-86	parathyroid hormone	Homo sapiens	23-26
29065130-12	2017	Moreover, a direct effect of smoking on vitamin D levels is proposed as a novel mechanism, which may account for both insulin resistance and COPD development.	Vitamin D	40-49	insulin	Homo sapiens	118-125
29118583-1	2017	Objective: To determine if vitamin D deficiency was associated with higher odds of left ventricular dysfunction among patients with acute coronary syndrome (ACS) and, if so, to determine whether this association was mediated by increased inflammation as measured by C-reactive protein (CRP) and white blood cell count (WBC).	Vitamin D	27-36	C-reactive protein	Homo sapiens	286-289
29055009-1	2017	Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-36
29055009-2	2017	A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.	Vitamin D	292-301	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	74-81
29055009-2	2017	A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.	Vitamin D	292-301	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	147-154
29055009-2	2017	A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.	Vitamin D	292-301	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	147-154
28808057-3	2017	Despite its importance in vitamin D metabolism, the molecular mechanisms underlying the regulation of the gene for this enzyme, Cyp27b1, are unknown.	Vitamin D	26-35	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	128-135
28707894-3	2017	The present study primarily focused on the creation of a condition that prevents the genomic or nongenomic action of vitamin D by disrupting vitamin D receptors (VDR or PDIA3/1,25MARRS); the effects of these disruptions on the series of proteins involved in secretases that play a crucial role in amyloid pathology and on amyloid beta (Abeta) production in primary cortical neurons were observed.	Vitamin D	117-126	protein disulfide isomerase family A, member 3	Rattus norvegicus	169-176
28836077-7	2017	CONCLUSIONS: Patients with T2D display a marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory, glycometabolic and lipid profile and lower vitamin D levels.	Vitamin D	177-186	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
28886997-0	2017	Analysis of the binding sites of vitamin D 1alpha-hydroxylase (CYP27B1) and vitamin D 24-hydroxylase (CYP24A1) for the design of selective CYP24A1 inhibitors: Homology modelling, molecular dynamics simulations and identification of key binding requirements.	Vitamin D	33-42	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	63-70
30483536-8	2017	SMT + vitamin D group had significant increase in mean serum levels of adiponectin (836 +- 309 and 908 +- 312 (pg/mL), P = 0.018) compared with the baseline; tumor necrosis factor-alpha levels decreased from baseline but the change was not significant.	Vitamin D	6-15	adiponectin, C1Q and collagen domain containing	Homo sapiens	71-82
30483536-9	2017	Conclusion: Patients with NAFLD given vitamin D in addition to lifestyle modifications have significant improvement in serum ALT and serum adiponectin levels.	Vitamin D	38-47	adiponectin, C1Q and collagen domain containing	Homo sapiens	139-150
27663530-2	2017	The expression of LL-37 is controlled by various factors, including vitamin D.	Vitamin D	68-77	cathelicidin antimicrobial peptide	Homo sapiens	18-23
27663530-3	2017	Thus, any disturbances in vitamin D level may influence LL-37 production and, possibly, affect wound healing.	Vitamin D	26-35	cathelicidin antimicrobial peptide	Homo sapiens	56-61
27663530-4	2017	Since deficiency of vitamin D was identified as a common problem in the population, this proof of concept study aimed to verify the relationship between serum levels of LL-37, vitamin D, and healing rate of venous leg ulcers.	Vitamin D	20-29	cathelicidin antimicrobial peptide	Homo sapiens	169-174
28816551-2	2017	The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection.	Vitamin D	157-166	interleukin 34	Homo sapiens	13-18
28674792-6	2017	Vitamin D treatment led to a significant reduction in adipose tissue TNF-alpha concentrations in both ND + vitamin D and HFD + vitamin D groups (P &lt; 0.05).	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	69-78
28674792-6	2017	Vitamin D treatment led to a significant reduction in adipose tissue TNF-alpha concentrations in both ND + vitamin D and HFD + vitamin D groups (P &lt; 0.05).	Vitamin D	107-116	tumor necrosis factor	Rattus norvegicus	69-78
29137465-7	2017	CONCLUSION: Overall, the results of this study demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks among patients with PCOS had beneficial effects on insulin metabolism and markers of cardio-metabolic risk.	Vitamin D	88-97	insulin	Homo sapiens	181-188
28816551-6	2017	These findings suggest that the induction of IL-34 expression by 1alpha,25(OH)2D3 may constitute a mechanism that explains the protective function of vitamin D in Alzheimer"s disease.	Vitamin D	150-159	interleukin 34	Homo sapiens	45-50
28816551-3	2017	The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3].	Vitamin D	128-137	interleukin 34	Homo sapiens	55-60
28835974-11	2017	Some patients continue to exhibit clinical symptoms despite adequate calcium levels; in these cases s. c. parathyroid hormone 1-84 should be considered to stabilize calcium levels and to lower the dosage of calcium and vitamin D supplements.	Vitamin D	219-228	parathyroid hormone	Homo sapiens	106-127
28867886-1	2017	INTRODUCTION: Insulin resistance is one of the most common features of polycystic ovary syndrome, and some studies suggest that vitamin D deficiency may have role in insulin resistance.	Vitamin D	128-137	insulin	Homo sapiens	166-173
28675610-7	2017	The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin.	Vitamin D	18-27	insulin	Homo sapiens	126-133
28867886-14	2017	In the study decreased serum fasting insulin level and fasting blood sugar after vitamin D supplementation suggest underlying role of vitamin D in glucose homeostasis.	Vitamin D	134-143	insulin	Homo sapiens	37-44
27473561-3	2017	The 1alpha-hydroxylation of 25(OH)D in the kidney by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)2D).	Vitamin D	88-97	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	53-60
27637326-0	2017	BRAF signals to pro-apoptotic BIM to enhance AraC cytotoxicity induced in AML cells by Vitamin D-based differentiation agents.	Vitamin D	87-96	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	notch receptor 1	Homo sapiens	48-53
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	notch receptor 1	Homo sapiens	75-81
27693423-8	2017	The VDR is ubiquitously expressed and activated vitamin D is a regulator of insulin, aromatase, and osteocalcin.	Vitamin D	48-57	insulin	Homo sapiens	76-83
28130182-11	2017	The major findings of this study are that vitamin D can be converted to the active form when topically administered to the airway, and this could be used to increase CFTR levels in patients with CF.	Vitamin D	42-51	CF transmembrane conductance regulator	Homo sapiens	166-170
27693423-8	2017	The VDR is ubiquitously expressed and activated vitamin D is a regulator of insulin, aromatase, and osteocalcin.	Vitamin D	48-57	bone gamma-carboxyglutamate protein	Homo sapiens	100-111
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	notch receptor 2	Homo sapiens	83-89
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	nuclear factor kappa B subunit 1	Homo sapiens	120-128
27932304-1	2017	Vitamin D deficiency is associated with a decreased insulin release, insulin resistance and type 2 diabetes in experimental and epidemiological studies.	Vitamin D	0-9	insulin	Homo sapiens	52-59
27932304-1	2017	Vitamin D deficiency is associated with a decreased insulin release, insulin resistance and type 2 diabetes in experimental and epidemiological studies.	Vitamin D	0-9	insulin	Homo sapiens	69-76
28161531-11	2017	Furthermore, DBP levels in the muscle correlated with FoxO1, suggesting an association between muscle protein breakdown and the activation of the vitamin D-endocrine pathway in muscle surrounding an OA affected joint.	Vitamin D	146-155	D-box binding PAR bZIP transcription factor	Homo sapiens	13-16
27932304-7	2017	A possible causal relationship between vitamin D deficiency and type 2 diabetes should be proven by randomized clinical trials showing that either type 2 diabetes can be prevented or insulin release and insulin sensitivity can be improved by vitamin D supplements.	Vitamin D	39-48	insulin	Homo sapiens	183-210
27932304-7	2017	A possible causal relationship between vitamin D deficiency and type 2 diabetes should be proven by randomized clinical trials showing that either type 2 diabetes can be prevented or insulin release and insulin sensitivity can be improved by vitamin D supplements.	Vitamin D	242-251	insulin	Homo sapiens	183-210
28007531-1	2017	Vitamin D deficiency has reached epidemic proportions worldwide and has recently been linked to cardiometabolic risk factors including obesity, insulin resistance, hypertension, dyslipidemia, as well as type 2 diabetes and cardiovascular disease.	Vitamin D	0-9	insulin	Homo sapiens	144-151
28161531-11	2017	Furthermore, DBP levels in the muscle correlated with FoxO1, suggesting an association between muscle protein breakdown and the activation of the vitamin D-endocrine pathway in muscle surrounding an OA affected joint.	Vitamin D	146-155	forkhead box O1	Homo sapiens	54-59
28216083-9	2017	DISCUSSION: Here, we report a significant association between maternal vitamin D status and the expression of sFlt-1 and VEGF at the mRNA level.	Vitamin D	71-80	vascular endothelial growth factor A	Homo sapiens	121-125
28229929-2	2017	The active hormone of the vitamin D pathway, 1,25-dihydroxyvitamin D3 (1,25D), stimulates nitric oxide and beta-defensin responses in bovine monocyte cultures, but the effect of 1,25D on innate immune genes in the mammary gland remained unknown.	Vitamin D	26-35	LOC100296173	Bos taurus	107-120
29135297-2	2017	Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	78-97
28931466-2	2017	The principal function of vitamin D in calcium homeostasis is to increase the absorption of calcium from the intestine, and the level of alkaline phosphatase (ALP) activity, a differentiation marker for intestinal epithelial cells, is regulated by vitamin D.	Vitamin D	248-257	alkaline phosphatase, placental	Homo sapiens	137-157
28931466-2	2017	The principal function of vitamin D in calcium homeostasis is to increase the absorption of calcium from the intestine, and the level of alkaline phosphatase (ALP) activity, a differentiation marker for intestinal epithelial cells, is regulated by vitamin D.	Vitamin D	248-257	alkaline phosphatase, placental	Homo sapiens	159-162
28931466-6	2017	In this study, we investigated the influence of vitamin D on the expression of 2 types of alternative mRNA variants encoding the human alkaline phosphatase, intestinal (ALPI) gene in human Caco-2 cells as an in vitro model of the small intestinal epithelium.	Vitamin D	48-57	alkaline phosphatase, intestinal	Homo sapiens	135-174
28931466-9	2017	Reverse transcription-polymerase chain reaction analysis revealed that expression of the 2 types of alternative mRNA variants from the ALPI gene was markedly enhanced by vitamin D in Caco-2 cells.	Vitamin D	170-179	alkaline phosphatase, intestinal	Homo sapiens	135-139
28931466-10	2017	In conclusion, these findings agree with the hypothesis: vitamin D up-regulated the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells; vitamin D may be an important regulator of ALPI gene expression in gut homeostasis.	Vitamin D	57-66	alkaline phosphatase, intestinal	Homo sapiens	115-146
28931466-10	2017	In conclusion, these findings agree with the hypothesis: vitamin D up-regulated the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells; vitamin D may be an important regulator of ALPI gene expression in gut homeostasis.	Vitamin D	57-66	alkaline phosphatase, intestinal	Homo sapiens	237-241
28931466-10	2017	In conclusion, these findings agree with the hypothesis: vitamin D up-regulated the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells; vitamin D may be an important regulator of ALPI gene expression in gut homeostasis.	Vitamin D	194-203	alkaline phosphatase, intestinal	Homo sapiens	115-146
28931466-10	2017	In conclusion, these findings agree with the hypothesis: vitamin D up-regulated the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells; vitamin D may be an important regulator of ALPI gene expression in gut homeostasis.	Vitamin D	194-203	alkaline phosphatase, intestinal	Homo sapiens	237-241
29135297-2	2017	Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important.	Vitamin D	158-167	parathyroid hormone	Homo sapiens	78-97
28843271-0	2017	Vitamin D Proliferates Vaginal Epithelium through RhoA Expression in Postmenopausal Atrophic Vagina tissue.	Vitamin D	0-9	ras homolog family member A	Homo sapiens	50-54
29267494-13	2017	Vitamin D was negatively correlated with Alx@75 augmentation pressure, parathyroid hormone, proteinuria and body mass index, and positively correlated with albumin, hemoglobin, eGFR, calcium and transferrin.	Vitamin D	0-9	transferrin	Homo sapiens	195-206
28948825-4	2017	First, an inverse correlation of vitamin D with parathormone, insulin secretion (C peptide, insulin) and its efficiency (HOMA IR) disappeared.	Vitamin D	33-42	insulin	Homo sapiens	62-69
28948825-5	2017	Relationships of vitamin D to hepatic insulin resistance (insulin/C peptide), to DHEA (both negative), and to DHEAS/DHEA ratio (positive) were newly found.	Vitamin D	17-26	insulin	Homo sapiens	38-45
28579119-5	2017	The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes.	Vitamin D	82-91	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	44-51
28579119-5	2017	The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes.	Vitamin D	252-261	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	44-51
28579119-5	2017	The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes.	Vitamin D	252-261	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	44-51
28768705-2	2017	In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1.	Vitamin D	8-17	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	121-128
28470739-6	2017	Vitamin D status at baseline was correlated negatively with haptoglobin, erythrocyte sedimentation rate and immunoglobulin A concentration.	Vitamin D	0-9	haptoglobin	Homo sapiens	60-71
28470739-8	2017	Vitamin D treatment was associated with reduced CD279 (PD-1) expression on CD4+ and CD8+ T cells, as well as decreased frequency of CD8+ T cells co-expressing the activation markers CD38 and human leucocyte antigen D-related (HLA-DR) in a dose-dependent manner.	Vitamin D	0-9	CD38 molecule	Sus scrofa	182-186
28662432-2	2017	Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	65-72
28662432-2	2017	Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	73-78
28957454-2	2017	Objective: The aim of this systematic review and meta-analysis was to determine the effect of vitamin D supplementation and improved vitamin D status on glycemia and insulin resistance in type 2 diabetic patients.	Vitamin D	94-103	insulin	Homo sapiens	166-173
28957454-2	2017	Objective: The aim of this systematic review and meta-analysis was to determine the effect of vitamin D supplementation and improved vitamin D status on glycemia and insulin resistance in type 2 diabetic patients.	Vitamin D	133-142	insulin	Homo sapiens	166-173
28957454-9	2017	Conclusions: Vitamin D supplementation, a minimum dose of 100 microg/d (4000 IU/d), may significantly reduce serum FPG, HbA1c, and HOMA-IR index, and helps to control glycemic response and improve insulin sensitivity in type 2 diabetic patients.	Vitamin D	13-22	insulin	Homo sapiens	197-204
28732681-1	2017	Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described.	Vitamin D	104-113	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
28732681-1	2017	Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described.	Vitamin D	195-204	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
29044032-9	2017	Significant correlation was between low levels of vitamin D and high levels of serum insulin (p=0,014) and high levels of HbA1c (p =0,015), independent of BMI.	Vitamin D	50-59	insulin	Homo sapiens	85-92
29044032-12	2017	It is possible that vitamin D deficiency has an effect on cardiovascular risk early in life through insulin resistance and altered blood sugar control.	Vitamin D	20-29	insulin	Homo sapiens	100-107
29044032-14	2017	Key words: Vitamin D, cardiovascular risk factors, insulin Correspondence: Emil L. Sigurdsson emilsig@hi.is.	Vitamin D	11-20	insulin	Homo sapiens	51-58
28070798-4	2017	In particular, cells of the immune system (B cells, T cells, and antigen presenting cells), due to the expression of 1alpha-hydroxylase (CYP27B1), are able to synthesize the active metabolite of vitamin D, which shows immunomodulatory properties.	Vitamin D	195-204	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	137-144
28102491-3	2017	Increasing evidence suggests that vitamin D might have a regulatory role in polycystic ovary syndrome (PCOS)-associated symptoms, including ovulatory dysfunction, insulin resistance and hyperandrogenism.	Vitamin D	34-43	insulin	Homo sapiens	163-170
28937066-0	2017	Relationship of insulin resistance to vitamin d status in children with nondiabetic chronic kidney disease.	Vitamin D	38-47	insulin	Homo sapiens	16-23
28835676-13	2017	Individuals with homozygous p.Ser267Phe in SLC10A1 are prone to vitamin D deficiency, deviated sex hormones and blood lipids.	Vitamin D	64-73	solute carrier family 10 member 1	Homo sapiens	43-50
28853522-11	2017	The addition of vitamin D significantly down-regulated IL6 and IL8 secretion and up-regulated ADAMST13 expression.	Vitamin D	16-25	interleukin 6	Homo sapiens	55-58
28853522-11	2017	The addition of vitamin D significantly down-regulated IL6 and IL8 secretion and up-regulated ADAMST13 expression.	Vitamin D	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
28573424-15	2017	Hormonal vitamin D [calcitriol] can inhibit the SEB-induced TNF expression in microglial cells.	Vitamin D	9-18	tumor necrosis factor	Homo sapiens	60-63
28679142-0	2017	Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.	Vitamin D	33-42	insulin	Homo sapiens	84-91
28679142-1	2017	The current study was conducted to evaluate the effects of 2 different doses of vitamin D supplementation on metabolic profiles of insulin-resistant patients with polycystic ovary syndrome (PCOS).	Vitamin D	80-89	insulin	Homo sapiens	131-138
28679142-6	2017	Overall, vitamin D supplementation at a dosage of 4 000 IU/day for 12 weeks in insulin-resistant patients with PCOS had beneficial effects of glucose metabolism and lipid profiles compared with 1 000 IU/day of vitamin D and placebo groups.	Vitamin D	9-18	insulin	Homo sapiens	79-86
28256004-1	2017	BACKGROUND AND OBJECTIVE: Vitamin D-binding protein (DBP) is a highly expressed plasma protein with many important functions, including transport of vitamin D metabolites, sequestration of actin, control of bone metabolism and modulation of immune and inflammatory responses.	Vitamin D	149-158	D-box binding PAR bZIP transcription factor	Homo sapiens	53-56
28843271-12	2017	The results suggest that vitamin D positively regulates cell-to-cell junction by increasing the VDR/p-RhoA/p-Ezrin pathway.	Vitamin D	25-34	ras homolog family member A	Homo sapiens	102-106
28927245-7	2017	Clinical trials support a marginal reduction in circulating lipids, and some meta-analyses support an increase in insulin sensitivity, following vitamin D supplementation.	Vitamin D	145-154	insulin	Homo sapiens	114-121
28257826-2	2017	Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR).	Vitamin D	174-183	D-box binding PAR bZIP transcription factor	Homo sapiens	238-241
28906453-4	2017	Furthermore, several pieces of experimental data have shown the anti-fibrotic, anti-inflammatory and insulin-sensitizing properties exerted by vitamin D on hepatic cells.	Vitamin D	143-152	insulin	Homo sapiens	101-108
29207798-13	2017	Conclusion: Oral Vitamin D may serve as an adjuvant to insulin therapy for children with T1DM by augmenting residual beta-cell function and improving insulin secretion.	Vitamin D	17-26	insulin	Homo sapiens	150-157
28578001-9	2017	These findings indicate that p38alpha and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 expression.	Vitamin D	82-91	mitogen-activated protein kinase 14	Homo sapiens	29-37
28732681-1	2017	Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described.	Vitamin D	195-204	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
28817905-0	2017	Re: CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations.	Vitamin D	61-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10
28906406-0	2017	Parathyroid hormone in relation to various vitamin D metabolites in adult females.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	0-19
28822353-1	2017	BACKGROUND: Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS).	Vitamin D	12-21	insulin	Homo sapiens	55-62
28811597-8	2017	With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p &lt; 0.005, 0.01, &lt; 0.001, &lt; 0.005, 0.03 and 0.01, respectively).	Vitamin D	5-14	insulin	Homo sapiens	137-144
28794437-7	2017	A genotypic effect on response to TNFalpha stimuli was detected, which was inhibited by vitamin D.	Vitamin D	88-97	tumor necrosis factor	Homo sapiens	34-42
28647612-9	2017	To that effect, micronutrients such as vitamin D and carotenoids or dietary macronutrient composition are elucidated with respect to APOE evolution.	Vitamin D	39-48	apolipoprotein E	Homo sapiens	133-137
28801380-5	2017	Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively.	Vitamin D	11-20	interleukin 4	Homo sapiens	104-108
28801380-5	2017	Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively.	Vitamin D	11-20	tumor necrosis factor	Homo sapiens	148-157
28801380-5	2017	Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively.	Vitamin D	11-20	interferon gamma	Homo sapiens	159-168
28536054-6	2017	We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production.	Vitamin D	81-90	interferon gamma	Homo sapiens	24-40
28536054-6	2017	We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production.	Vitamin D	81-90	interferon gamma	Homo sapiens	42-50
28536054-6	2017	We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production.	Vitamin D	81-90	CD4 molecule	Homo sapiens	65-68
28536054-6	2017	We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production.	Vitamin D	190-199	interferon gamma	Homo sapiens	204-212
28573424-0	2017	Vitamin D inhibits the Staphylococcal enterotoxin B-induced expression of tumor necrosis factor in microglial cells.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	74-95
28843271-11	2017	Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR).	Vitamin D	0-9	ras homolog family member A	Homo sapiens	81-85
28670428-2	2017	The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin and reproduction processing are introduced.	Vitamin D	13-22	insulin	Homo sapiens	89-96
28714882-0	2017	Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients.	Vitamin D	0-9	Bardet-Biedl syndrome 9	Homo sapiens	35-38
28714882-9	2017	After 6 months, vitamin D supplementation significantly enhanced plasma C18dihydroceramide (dhCer; N-stearoyl-sphinganine (d18:0/18:0)) and C18ceramide (Cer; N-stearoyl-sphingosine (d18:1/18:0)) levels were observed in the verum group compared to the placebo group.	Vitamin D	16-25	Bardet-Biedl syndrome 9	Homo sapiens	72-75
28714882-11	2017	Taken together, vitamin D supplementation induced changes of the C18 chain-length-specific dhCer and Cer plasma levels in patients with T2D.	Vitamin D	16-25	Bardet-Biedl syndrome 9	Homo sapiens	65-68
28714882-12	2017	The regulation of sphingolipid signaling by vitamin D may thus unravel a novel mechanism by which vitamin D can influence glucose utilization and insulin action.	Vitamin D	44-53	insulin	Homo sapiens	146-153
28714882-12	2017	The regulation of sphingolipid signaling by vitamin D may thus unravel a novel mechanism by which vitamin D can influence glucose utilization and insulin action.	Vitamin D	98-107	insulin	Homo sapiens	146-153
28276579-0	2017	Glucose homeostasis, beta cell function, and insulin resistance in relation to vitamin D status after gestational diabetes mellitus.	Vitamin D	79-88	insulin	Homo sapiens	45-52
28276579-11	2017	CONCLUSION: Vitamin D deficiency/insufficiency in previous GDM cases appears to be associated with beta cell dysfunction and insulin resistance, but not with postpartum diabetes when factors well known to influence type-2 diabetes were adjusted for.	Vitamin D	12-21	insulin	Homo sapiens	125-132
28468770-0	2017	Effects of Vitamin D Supplementation on Insulin Sensitivity and Insulin Secretion in Subjects With Type 2 Diabetes and Vitamin D Deficiency: A Randomized Controlled Trial.	Vitamin D	11-20	insulin	Homo sapiens	40-47
28468770-0	2017	Effects of Vitamin D Supplementation on Insulin Sensitivity and Insulin Secretion in Subjects With Type 2 Diabetes and Vitamin D Deficiency: A Randomized Controlled Trial.	Vitamin D	11-20	insulin	Homo sapiens	64-71
28468770-1	2017	OBJECTIVE: In observational studies, low vitamin D levels are associated with type 2 diabetes (T2D), impaired glucose metabolism, insulin sensitivity, and insulin secretion.	Vitamin D	41-50	insulin	Homo sapiens	130-137
28468770-2	2017	We evaluated the efficacy of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with T2D and low vitamin D (25-hydroxyvitamin D [25(OH)D] &lt;50 nmol/L).	Vitamin D	29-38	insulin	Homo sapiens	58-65
28509078-9	2017	Vitamin D treatment reduced IL-6 level after 16 weeks (p = 0.027).	Vitamin D	0-9	interleukin 6	Homo sapiens	28-32
28509078-10	2017	Compared to baseline, vascular cell adhesion molecule-1 and E-selectin levels decreased significantly in vitamin D treated subjects; however, there were no significant differences between two groups.	Vitamin D	105-114	vascular cell adhesion molecule 1	Homo sapiens	22-55
28370465-6	2017	These findings uncover crosstalk between the BMP-Smad1 and RANKL-NF-kappaB pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health.	Vitamin D	146-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-74
28659589-0	2017	Vitamin D Modulation of TRAIL Expression in Human Milk and Mammary Epithelial Cells.	Vitamin D	0-9	TNF superfamily member 10	Homo sapiens	24-29
27671249-0	2017	Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats.	Vitamin D	29-38	phosphoglycolate phosphatase	Rattus norvegicus	151-155
28665937-8	2017	Treatment with 25 or 1,25 vitamin D decreased IL-6 and TLR9.	Vitamin D	26-35	interleukin 6	Homo sapiens	46-50
28665937-9	2017	CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-gamma, TLR7 and TLR9 expression.	Vitamin D	53-62	interleukin 6	Homo sapiens	101-105
28665937-9	2017	CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-gamma, TLR7 and TLR9 expression.	Vitamin D	53-62	interferon gamma	Homo sapiens	107-116
28665937-9	2017	CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-gamma, TLR7 and TLR9 expression.	Vitamin D	53-62	toll like receptor 7	Homo sapiens	118-122
28025696-0	2017	Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer.	Vitamin D	13-22	nuclear receptor subfamily 4 group A member 1	Homo sapiens	36-52
28025696-0	2017	Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer.	Vitamin D	13-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
28025696-5	2017	METHOD: In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today.	Vitamin D	122-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	209-213
28978056-0	2017	Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes.	Vitamin D	0-9	insulin	Homo sapiens	28-35
28978056-1	2017	Vitamin D deficiency could cause insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	33-40
28659589-3	2017	While tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been implicated in cellular growth/apoptosis, immune cell function and bone-resorbing osteoclast formation, the expression of TRAIL in human milk as a function of vitamin D status in mothers remains unknown.	Vitamin D	237-246	TNF superfamily member 10	Homo sapiens	63-68
28659589-4	2017	We hypothesized that vitamin D deficiency alters TRAIL protein levels in human breast milk and mammary epithelial cells.	Vitamin D	21-30	TNF superfamily member 10	Homo sapiens	49-54
28659589-5	2017	Milk from vitamin D deficient mothers showed high levels of TRAIL (alpha and beta) proteins compared to milk from vitamin D replete women.	Vitamin D	10-19	TNF superfamily member 10	Homo sapiens	60-65
28659589-6	2017	Western blot analysis of total cell lysate obtained from normal human mammary epithelial (HME-1) cells treated with variable doses (0-20 nM) of vitamin D for 24 h demonstrated that low levels (0.5 to 5 nM) significantly increased the TRAIL alpha but no change in beta expression.	Vitamin D	144-153	TNF superfamily member 10	Homo sapiens	234-239
28659589-7	2017	In contrast, vitamin D at 20 nM concentration suppressed the expression of both TRAIL alpha and beta proteins.	Vitamin D	13-22	TNF superfamily member 10	Homo sapiens	80-85
28659589-8	2017	Consistently, vitamin D regulated TRAIL mRNA expression in HME-1 cells.	Vitamin D	14-23	TNF superfamily member 10	Homo sapiens	34-39
28659589-9	2017	Our results indicate that vitamin D status in mothers modulates TRAIL expression in breast milk, which may have implications for both mother and infant health.	Vitamin D	26-35	TNF superfamily member 10	Homo sapiens	64-69
28695056-5	2017	mTOR mRNA levels were higher (P=0.036) and LC3 mRNA levels were lower (P&lt;0.001) in severe vitamin D deficiency group compared to vitamin D insufficiency group.	Vitamin D	93-102	mechanistic target of rapamycin kinase	Homo sapiens	0-4
28690912-12	2017	Our study revealed that rickets-like features have a tendency to present atypically in FHH patients who have a mild vitamin D deficiency, and that CaSR mutations may have a partial role in the pathogenesis of skeletal deformities.	Vitamin D	116-125	calcium sensing receptor	Homo sapiens	87-90
28629132-0	2017	Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial.	Vitamin D	11-20	insulin like growth factor 1	Homo sapiens	40-45
28629132-1	2017	Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1).	Vitamin D	60-69	insulin like growth factor 1	Homo sapiens	104-109
28629326-8	2017	Moreover, vitamin D administration, significantly reduced catalase activity in ND + vitamin D and HFD + vitamin D groups (P &lt; 0.05).	Vitamin D	10-19	catalase	Rattus norvegicus	58-66
28629326-8	2017	Moreover, vitamin D administration, significantly reduced catalase activity in ND + vitamin D and HFD + vitamin D groups (P &lt; 0.05).	Vitamin D	84-93	catalase	Rattus norvegicus	58-66
28629326-8	2017	Moreover, vitamin D administration, significantly reduced catalase activity in ND + vitamin D and HFD + vitamin D groups (P &lt; 0.05).	Vitamin D	84-93	catalase	Rattus norvegicus	58-66
28629326-9	2017	TNF-alpha concentration in heart tissue in ND + vitamin D group significantly reduced compared with ND group.	Vitamin D	48-57	tumor necrosis factor	Rattus norvegicus	0-9
28695056-6	2017	The counts of CD4+ T cells and the CD4/CD8 ratio were significantly higher in severe vitamin D deficiency group compared to vitamin D insufficiency group (P=0.001, P&lt;0.001,respectively).	Vitamin D	85-94	CD4 molecule	Homo sapiens	14-17
28695056-6	2017	The counts of CD4+ T cells and the CD4/CD8 ratio were significantly higher in severe vitamin D deficiency group compared to vitamin D insufficiency group (P=0.001, P&lt;0.001,respectively).	Vitamin D	85-94	CD4 molecule	Homo sapiens	35-38
28231019-1	2017	Vitamin D is a regulator of host defense against infections and induces expression of the antimicrobial peptide hCAP18/LL-37.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	112-118
28617856-15	2017	In those with concurrent vitamin D deficiency, having an A allele significantly increased their risk of having insulin resistance compared to G allele (adjusted OR = 2.66 (95% CI 1.36-5.19, p = 0.004).	Vitamin D	25-34	insulin	Homo sapiens	111-118
28490514-3	2017	We hypothesized that vitamin D supplementation would improve insulin sensitivity and secretion compared with placebo.Design: Sixty-five overweight or obese, vitamin D-deficient (25-hydroxyvitamin D [25(OH)D] concentration &lt;=50 nmol/L) adults were randomly assigned to receive either a bolus oral dose of 100,000 IU cholecalciferol followed by 4000 IU cholecalciferol/d or a matching placebo for 16 wk.	Vitamin D	21-30	insulin	Homo sapiens	61-68
28587998-1	2017	OBJECTIVE: Vitamin D-dependent rickets type IA (VDDR-IA) is a rare autosomal recessive disorder characterized by the early onset of severe rickets.	Vitamin D	11-20	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	48-52
28231019-8	2017	We found that TNF-alpha/IL-1beta treatment reduced vitamin D-induced expression of hCAP18/LL-37 and killing of nontypeable H. influenzae.	Vitamin D	51-60	cathelicidin antimicrobial peptide	Homo sapiens	83-89
28537499-0	2017	Vitamin D improves the content of TGF-beta and IGF-1 in intervertebral disc of diabetic rats.	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	34-42
28697816-4	2017	After adjustment for confounders, children of vitamin D-deficient mothers (&lt;50 0 nmol/l) were more likely to have scores in the lowest quartile for gross-motor development at 30 months (OR 1 20; 95 % CI 1 03, 1 40), fine-motor development at 30 months (OR 1 23; 95 % CI 1 05, 1 44) and social development at 42 months (OR 1 20; 95 % CI 1 01, 1 41) than vitamin D-sufficient mothers (&gt;=50 0 nmol/l).	Vitamin D	46-55	olfactory receptor family 6 subfamily N member 2	Homo sapiens	256-263
28475987-0	2017	Attenuated PTH responsiveness to vitamin D deficiency among patients with type 2 diabetes and chronic hyperglycemia.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	11-14
28475987-1	2017	BACKGROUND: The short and long-term relationship between hyperglycemia and PTH level among patients suffering from both diabetes type 2 and vitamin D deficiency were evaluated.	Vitamin D	140-149	parathyroid hormone	Homo sapiens	75-78
28475987-10	2017	CONCLUSIONS: Chronic hyperglycemia, as assessed by A1C level, is associated with a significantly attenuated PTH responsiveness to vitamin D deficiency without a significant change in calcium level.	Vitamin D	130-139	parathyroid hormone	Homo sapiens	108-111
28537499-10	2017	CONCLUSION: Vitamin D can protect the degeneration of intervertebral disc and improve the content of transforming growth factor-beta and insulin-like growth factor-1 in the intervertebral disc, which provides a new idea for the prevention and treatment of degenerative changes of the intervertebral disc in diabetic patients.	Vitamin D	12-21	insulin like growth factor 1	Homo sapiens	137-165
28537499-13	2017	And Vitamin D prevented the discs by improving the content of TGF-beta and IGF-1.	Vitamin D	4-13	transforming growth factor, beta 1	Rattus norvegicus	62-70
28653944-8	2017	A significant difference was found between the women with and without severe vitamin D deficiency with regard to waist circumference, fasting insulin level and HOMA-IR, and abnormal systolic and diastolic blood pressures.	Vitamin D	77-86	insulin	Homo sapiens	142-149
28647929-3	2017	OBJECTIVES: To evaluate whether the vitamin D status among residents in a single medical center in Tel Aviv is below the normal range.	Vitamin D	36-45	ETS variant transcription factor 6	Homo sapiens	99-102
28368445-0	2017	Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts.	Vitamin D	0-9	caspase 3	Homo sapiens	43-55
28368445-14	2017	Inhibition of caspase-3 cleavage and ROCK1 activation, together with upregulation of eNOS expression, could be the potential cellular/molecular mechanism(s) of vitamin D protective effects on placental trophoblasts.	Vitamin D	160-169	caspase 3	Homo sapiens	14-23
28368445-14	2017	Inhibition of caspase-3 cleavage and ROCK1 activation, together with upregulation of eNOS expression, could be the potential cellular/molecular mechanism(s) of vitamin D protective effects on placental trophoblasts.	Vitamin D	160-169	nitric oxide synthase 3	Homo sapiens	85-89
27987058-7	2017	Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2).	Vitamin D	64-73	interleukin 10	Mus musculus	150-155
27987058-7	2017	Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2).	Vitamin D	64-73	CD163 antigen	Mus musculus	232-237
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	108-115
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	166-173
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	253-260
28440468-0	2017	Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4.	Vitamin D	0-9	toll-like receptor 4	Rattus norvegicus	77-97
28440468-3	2017	Among all the signaling pathways involved, Toll-like receptor 4 (TLR4) has been demonstrated to play an important role, and is known to be regulated by vitamin D.	Vitamin D	152-161	toll-like receptor 4	Rattus norvegicus	43-63
28440468-3	2017	Among all the signaling pathways involved, Toll-like receptor 4 (TLR4) has been demonstrated to play an important role, and is known to be regulated by vitamin D.	Vitamin D	152-161	toll-like receptor 4	Rattus norvegicus	65-69
28440468-7	2017	The upregulation of TLR4 by hyperoxia was ameliorated by vitamin D and apoptosis was reduced.	Vitamin D	57-66	toll-like receptor 4	Rattus norvegicus	20-24
28440468-8	2017	Vitamin D administration antagonized the activation of TLR4 and therefore alleviated inflammation, reduced apoptosis and preserved lung structure.	Vitamin D	0-9	toll-like receptor 4	Rattus norvegicus	55-59
28376939-0	2017	Investigation of vitamin D status and its correlation with insulin resistance in a Chinese population.	Vitamin D	17-26	insulin	Homo sapiens	59-66
28376939-1	2017	OBJECTIVE: Although many studies worldwide have focused on the relationship between vitamin D and insulin resistance, results remain controversial.	Vitamin D	84-93	insulin	Homo sapiens	98-105
28376939-3	2017	We aimed to investigate vitamin D status and its correlation with insulin resistance among a Chinese adult population.	Vitamin D	24-33	insulin	Homo sapiens	66-73
28409320-2	2017	Vitamin D is a key hormone involved in the regulation of calcium/phosphorous balance and recently it has been implicated in the pathogenesis of sub-inflammation, insulin resistance and obesity.	Vitamin D	0-9	insulin	Homo sapiens	162-169
28062940-3	2017	Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic beta-cell function.	Vitamin D	0-9	insulin	Homo sapiens	101-108
28409320-6	2017	Regardless of the effect on inflammation, Vitamin D seems to directly increase insulin sensitivity and secretion, through different mechanisms.	Vitamin D	42-51	insulin	Homo sapiens	79-86
28409320-8	2017	Vitamin D status could alter the balance between pro and anti-inflammatory cytokines and thus affect insulin action, lipid metabolism and adipose tissue function and structure.	Vitamin D	0-9	insulin	Homo sapiens	101-108
28409320-9	2017	Numerous studies have shown that Vitamin D concentrations are inversely associated with pro-inflammatory markers, insulin resistance, glucose intolerance and obesity.	Vitamin D	33-42	insulin	Homo sapiens	114-121
28409320-11	2017	However, vitamin D supplementation in humans showed controversial effects: with some studies demonstrating improvements in insulin sensitivity, glucose and lipid metabolism while others showing no beneficial effect on glycemic control and on inflammation.	Vitamin D	9-18	insulin	Homo sapiens	123-130
28409320-12	2017	In conclusion, although the evidences of a significant role of Vitamin D on inflammation, insulin resistance and insulin secretion in the pathogenesis of obesity, metabolic syndrome and type 2 diabetes, its potential function in treatment and prevention of type 2 diabetes mellitus is unclear.	Vitamin D	63-72	insulin	Homo sapiens	90-97
28615947-4	2017	Another important player in regulating mineral metabolism is vitamin D receptor (VDR), which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	196-199
28620394-0	2017	Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNgamma Secretion.	Vitamin D	0-9	interferon gamma	Homo sapiens	139-147
28620394-4	2017	Paradoxically, vitamin D has repeatedly been ascribed an immune-suppressive function inhibiting Th1 differentiation and production of IFNgamma in T cells.	Vitamin D	15-24	interferon gamma	Homo sapiens	134-142
28620394-7	2017	We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12.	Vitamin D	140-149	interferon gamma	Homo sapiens	173-181
28620394-7	2017	We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12.	Vitamin D	140-149	interferon gamma	Homo sapiens	173-181
28620394-7	2017	We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12.	Vitamin D	140-149	interferon gamma	Homo sapiens	173-181
28620394-9	2017	In conclusion, we demonstrate that vitamin D counteracts M. tuberculosis-induced cathelicidin downregulation and allows Th1 differentiation and IFNgamma secretion.	Vitamin D	35-44	interferon gamma	Homo sapiens	144-152
28558021-10	2017	In particular, the associations with iFGF23 (positive) and 1,25D (negative) underline the relevant inhibitory action of Sclerostin on vitamin D activation.	Vitamin D	134-143	sclerostin	Homo sapiens	120-130
28493902-5	2017	RESULTS: Serum sclerostin, but not DKK1, increases in more advanced stages of CKD and associates with PTH, phosphate, and 1,25(OH)2 vitamin D concentrations.	Vitamin D	132-141	sclerostin	Homo sapiens	15-25
28558021-0	2017	Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation.	Vitamin D	58-67	sclerostin	Homo sapiens	16-26
31646124-9	2017	In unadjusted analysis, 25-hydroxy vitamin D levels were found to be correlated negatively with BMI (P=0.0005), LDL-C (P=0.01), and non-HDL-C (P=0.003) and correlated positively with HDL-C levels (P=0.006).	Vitamin D	24-44	component of oligomeric golgi complex 2	Homo sapiens	112-117
28251655-6	2017	After vitamin D supplementation, the change in 25(OH)D, 24,25(OH)2 D3 and VMR was associated with the change in calcium absorption, PTH and CTX.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	132-135
28489857-0	2017	Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults.	Vitamin D	0-9	thrombospondin 1	Homo sapiens	33-49
28489857-12	2017	CONCLUSIONS: Vitamin D supplementation in vitamin D insufficient, but otherwise healthy individuals markedly decreased TSP-1 levels and blood pressure.	Vitamin D	13-22	thrombospondin 1	Homo sapiens	119-124
28489857-12	2017	CONCLUSIONS: Vitamin D supplementation in vitamin D insufficient, but otherwise healthy individuals markedly decreased TSP-1 levels and blood pressure.	Vitamin D	42-51	thrombospondin 1	Homo sapiens	119-124
28486474-0	2017	Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.	Vitamin D	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	56-72
28486474-1	2017	BACKGROUND: Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE).	Vitamin D	28-37	immunoglobulin heavy constant epsilon	Homo sapiens	125-141
28486474-1	2017	BACKGROUND: Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE).	Vitamin D	28-37	immunoglobulin heavy constant epsilon	Homo sapiens	143-146
27715403-5	2017	Calcitriol, the active form of vitamin D, has been shown to decrease STAT1 and STAT3 phosphorylation in cancer cell lines and autoimmune disease mouse models.	Vitamin D	31-40	signal transducer and activator of transcription 3	Mus musculus	79-84
28464004-0	2017	Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons.	Vitamin D	0-9	interleukin 6	Homo sapiens	40-44
28464004-12	2017	In fully adjusted models, vitamin D associations with abnormal biomarker levels persisted for IL-6 levels and CX3CR1+ and CCR2+ phenotypes.	Vitamin D	26-35	interleukin 6	Homo sapiens	94-98
28464004-12	2017	In fully adjusted models, vitamin D associations with abnormal biomarker levels persisted for IL-6 levels and CX3CR1+ and CCR2+ phenotypes.	Vitamin D	26-35	C-C motif chemokine receptor 2	Homo sapiens	122-126
28095044-2	2017	Vitamin D3 undergoes conversion through a multitude of enzymatic reactions described within the paper, and vitamin D levels are dependent on many factors including the vitamin D binding protein (DBP).	Vitamin D	107-116	D-box binding PAR bZIP transcription factor	Homo sapiens	195-198
28407660-0	2017	The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome.	Vitamin D	115-124	insulin	Homo sapiens	74-81
28599691-8	2017	Vitamin D levels were significantly low in the patients who had high IgE levels and high levels of specific IgE antibodies against inhalant allergens in asthmatic patients.	Vitamin D	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	69-72
28565795-3	2017	Elocalcitol (BXL-628), a vitamin D analog, has been suggested to be effective on the RhoA/Rho associated protein kinase (ROCK) pathway, which serves a crucial role in high glucose-induced EMT.	Vitamin D	25-34	ras homolog family member A	Homo sapiens	85-89
27927781-10	2017	Thus, common genetic variants located near genes involved in vitamin D metabolism and calcium and renal phosphate transport associated with differences in circulating PTH concentrations.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	167-170
28324001-0	2017	CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations.	Vitamin D	57-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
28324001-4	2017	CYP3A4 is a P450 enzyme that inactivates many drugs and xenobiotics and may represent an alternative pathway for inactivation of vitamin D metabolites.	Vitamin D	129-138	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
28324001-10	2017	Conclusion: These observations suggest that rifampin-induced overexpression of CYP3A4 provides an alternative pathway for inactivation of vitamin D metabolites in patients who lack CYP24A1 function.	Vitamin D	138-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-85
28599691-8	2017	Vitamin D levels were significantly low in the patients who had high IgE levels and high levels of specific IgE antibodies against inhalant allergens in asthmatic patients.	Vitamin D	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	108-111
28425954-6	2017	We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation.	Vitamin D	77-86	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	172-179
28403940-3	2017	METHODS: This is a systematic review of randomized controlled trials of vitamin D supplementation conducted in the MENA region.	Vitamin D	72-81	ENAH actin regulator	Homo sapiens	115-119
28403940-16	2017	CONCLUSION: In children, adolescents and pregnant women from the MENA, an intermediate vitamin D dose of 1000-2000IU daily may be necessary to allow for the majority of the population to reach a desirable 25(OH)D level of 20ng/ml.	Vitamin D	87-96	ENAH actin regulator	Homo sapiens	65-69
28101619-7	2017	The currently established reference range for the definition of a vitamin D deficiency came from studies where vitamin D deficiency was correlated to an increase in parathyroid hormone.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	165-184
28101619-7	2017	The currently established reference range for the definition of a vitamin D deficiency came from studies where vitamin D deficiency was correlated to an increase in parathyroid hormone.	Vitamin D	111-120	parathyroid hormone	Homo sapiens	165-184
28359360-2	2017	Fibroblast growth factor 21 (FGF21) and vitamin D status may improve insulin sensitivity.	Vitamin D	40-49	insulin	Homo sapiens	69-76
28359360-17	2017	CONCLUSIONS: Higher vitamin D status, but not FGF21, was associated with greater postprandial glucose oxidation and improved insulin sensitivity.	Vitamin D	20-29	insulin	Homo sapiens	125-132
28425954-6	2017	We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation.	Vitamin D	133-142	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	172-179
28423063-0	2017	Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana.	Vitamin D	0-9	insulin	Homo sapiens	42-49
28422993-9	2017	Anti-inflammatory vitamin D interfered with the IL-1beta release and suppressed caspase-5 in keratinocytes and in psoriatic skin lesions.	Vitamin D	18-27	interleukin 1 beta	Homo sapiens	48-56
28415985-5	2017	Patients were genotyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020, rs2282679), CYP2R1 (rs2060793, rs12794714), CYP27B1 (rs10877012), and DHCR7 (rs12785878).	Vitamin D	51-60	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	162-169
28120456-2	2017	A previous study demonstrated that hypercalcaemia induced by vitamin D in rats increased endothelin (ET)-1 expression in the distal nephron, which suggests the involvement of the ET system in hypercalcaemia-induced effects.	Vitamin D	61-70	endothelin 1	Rattus norvegicus	89-106
28284354-1	2017	Vitamin D binding protein (DBP) gene encodes for Gc, an alpha2 globulin that transports vitamin D metabolites in serum.	Vitamin D	88-97	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
28955749-12	2017	The 5"-flanking sequence of SLC13A4 contains multiple putative transcription factor consensus sites, including GATA-1, TATA-box and Vitamin D responsive elements.	Vitamin D	132-141	solute carrier family 13 member 4	Sus scrofa	28-35
28095043-0	2017	SERUM INSULIN-LIKE GROWTH FACTOR 1 IN LEBANESE SCHOOLCHILDREN AND ITS RELATION TO VITAMIN D AND FERRITIN LEVELS.	Vitamin D	82-91	insulin like growth factor 1	Homo sapiens	6-34
28373319-1	2017	Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial.	Vitamin D	10-19	insulin	Homo sapiens	46-53
26848580-1	2017	BACKGROUND: In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling.	Vitamin D	76-85	insulin	Homo sapiens	170-177
26848580-9	2017	The significant effect of vitamin D in diabetics and a tendency for an association with BMI may indicate a role of excess adiposity and insulin resistance in modulating the effects of vitamin D on vascular function.	Vitamin D	184-193	insulin	Homo sapiens	136-143
28372721-0	2017	Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess.	Vitamin D	0-9	growth hormone 1	Homo sapiens	17-31
28372721-0	2017	Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess.	Vitamin D	0-9	growth hormone 1	Homo sapiens	33-35
28372721-2	2017	GH directly regulates renal 1 alpha-hydroxylase activity, although the action of GH in modulating vitamin D metabolism may also be IGF-I mediated.	Vitamin D	98-107	growth hormone 1	Homo sapiens	81-83
28372721-3	2017	On the other hand, vitamin D increases circulating IGF-I and the vitamin D deficiency should be normalized before measurement of IGF-I concentrations to obtain reliable and unbiased IGF-I values.	Vitamin D	19-28	insulin like growth factor 1	Homo sapiens	51-56
28372721-4	2017	Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activation of the GH/IGF-I axis and it suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and GH/IGF-I secretion.	Vitamin D	53-62	growth hormone 1	Homo sapiens	121-123
28372721-4	2017	Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activation of the GH/IGF-I axis and it suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and GH/IGF-I secretion.	Vitamin D	53-62	insulin like growth factor 1	Homo sapiens	124-129
28372721-4	2017	Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activation of the GH/IGF-I axis and it suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and GH/IGF-I secretion.	Vitamin D	53-62	growth hormone 1	Homo sapiens	258-260
28372721-6	2017	In addition, data on the impact of GH treatment on vitamin D levels in GHD patients are quite conflicting.	Vitamin D	51-60	growth hormone 1	Homo sapiens	35-37
28372721-8	2017	The current review summarizes the available data on vitamin D in the main disorders of the GH/IGF-I axis, providing an overview of the current state of the art.	Vitamin D	52-61	growth hormone 1	Homo sapiens	91-93
28372721-8	2017	The current review summarizes the available data on vitamin D in the main disorders of the GH/IGF-I axis, providing an overview of the current state of the art.	Vitamin D	52-61	insulin like growth factor 1	Homo sapiens	94-99
27975188-0	2017	Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.	Vitamin D	0-9	C-reactive protein	Homo sapiens	63-81
28421785-13	2017	Vitamin D deficiency could contribute to the morbidities associated with childhood obesity, such as insulin resistance or diabetes mellitus, increased cardiovascular/cardiometabolic risks, atherogenic dyslipidemia, and hypertension.	Vitamin D	0-9	insulin	Homo sapiens	100-107
28353634-0	2017	Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats.	Vitamin D	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	89-93
28353634-0	2017	Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats.	Vitamin D	0-9	sirtuin 1	Rattus norvegicus	94-99
28353634-7	2017	In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1alpha, PGC1alpha, PPARalpha, VLCAD, LCAD, MCAD, and UCP1.	Vitamin D	13-22	PPARG coactivator 1 alpha	Rattus norvegicus	124-133
28353634-7	2017	In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1alpha, PGC1alpha, PPARalpha, VLCAD, LCAD, MCAD, and UCP1.	Vitamin D	13-22	acyl-CoA dehydrogenase, very long chain	Rattus norvegicus	146-151
28353634-7	2017	In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1alpha, PGC1alpha, PPARalpha, VLCAD, LCAD, MCAD, and UCP1.	Vitamin D	13-22	uncoupling protein 1	Rattus norvegicus	169-173
28353634-8	2017	Moreover, significant decrements of SIRT1 and AMPK activity were noted in obese rats fed with a vitamin D-insufficient diet.	Vitamin D	96-105	sirtuin 1	Rattus norvegicus	36-41
28353634-8	2017	Moreover, significant decrements of SIRT1 and AMPK activity were noted in obese rats fed with a vitamin D-insufficient diet.	Vitamin D	96-105	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	46-50
28353634-10	2017	SIRT1 and AMPK activity may play a role in the mechanism of vitamin D action.	Vitamin D	60-69	sirtuin 1	Rattus norvegicus	0-5
28353634-10	2017	SIRT1 and AMPK activity may play a role in the mechanism of vitamin D action.	Vitamin D	60-69	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	10-14
28350328-0	2017	Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial.	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	26-30
28350328-0	2017	Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial.	Vitamin D	72-81	vascular endothelial growth factor A	Homo sapiens	26-30
28350328-2	2017	Vitamin D (VitD) supplementation improves multiple clinical parameters in VitD-deficient women with PCOS and decreases VEGF levels in several other pathologic conditions.	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	119-123
28345644-5	2017	Vitamin D had no effect on BEAS-2B cells but enhanced the production of IL-8 in neutrophils (p = 0.007) and IL-1beta in macrophages (p = 0.007) in response to LPS.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28345644-5	2017	Vitamin D had no effect on BEAS-2B cells but enhanced the production of IL-8 in neutrophils (p = 0.007) and IL-1beta in macrophages (p = 0.007) in response to LPS.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	108-116
28341729-2	2017	This review summarizes the role of Vitamin D in maintaining the normal release of insulin by the pancreatic beta cells (beta-cells).	Vitamin D	35-44	insulin	Homo sapiens	82-89
28341729-6	2017	Vitamin D deficiency contributes to both the initial insulin resistance and the subsequent onset of diabetes caused by beta-cell death.	Vitamin D	0-9	insulin	Homo sapiens	53-60
28341729-7	2017	Vitamin D acts to reduce inflammation, which is a major process in inducing insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	76-83
28300755-0	2017	Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells.	Vitamin D	0-9	RUNX family transcription factor 2	Homo sapiens	36-41
28300755-6	2017	Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells.	Vitamin D	0-9	RUNX family transcription factor 2	Homo sapiens	47-52
28300755-7	2017	Vitamin D regulated Runx2 target genes or their products represent potential therapeutic targets and laboratory biomarkers for applications in translational oncology.	Vitamin D	0-9	RUNX family transcription factor 2	Homo sapiens	20-25
28054069-4	2017	Human keratinocytes contain the enzymatic machinery (CYP27B1) for the synthesis of the biologically most active natural vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), representing an autonomous vitamin D3 pathway.	Vitamin D	120-129	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	53-60
28296915-6	2017	Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped.	Vitamin D	27-36	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	90-97
28272298-0	2017	Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	6-25
28074487-2	2017	Prior investigation has also suggested that vitamin D levels may affect duration of therapy with anti-tumour necrosis factor-alpha (anti-TNF-alpha) medications among patients with IBD.	Vitamin D	44-53	tumor necrosis factor	Homo sapiens	137-146
28074487-3	2017	AIM: To evaluate the relationship between vitamin D levels and odds of reaching remission while on an anti-TNF-alpha medication.	Vitamin D	42-51	tumor necrosis factor	Homo sapiens	107-116
28074487-6	2017	A logistic regression model adjusting for age, gender, IBD diagnosis, anti-TNF-alpha medication (infliximab vs. adalimumab) and first or subsequent anti-TNF-alpha medication was used to identify the effect of vitamin D level on initial response to anti-TNF-alpha therapy.	Vitamin D	209-218	tumor necrosis factor	Homo sapiens	153-162
28074487-6	2017	A logistic regression model adjusting for age, gender, IBD diagnosis, anti-TNF-alpha medication (infliximab vs. adalimumab) and first or subsequent anti-TNF-alpha medication was used to identify the effect of vitamin D level on initial response to anti-TNF-alpha therapy.	Vitamin D	209-218	tumor necrosis factor	Homo sapiens	153-162
28074487-9	2017	CONCLUSIONS: These findings suggest that vitamin D levels may influence initial response to anti-TNF-alpha medication and that low vitamin D levels may pre-dispose patients to decreased odds of remission.	Vitamin D	41-50	tumor necrosis factor	Homo sapiens	97-106
28029003-0	2017	Effect of Vitamin D Status on Von Willebrand Factor and ADAMTS13 in Diabetic Patients on Chronic Hemodialysis.	Vitamin D	10-19	von Willebrand factor	Homo sapiens	30-51
28261302-0	2017	The vitamin D analogue paricalcitol attenuates hepatic ischemia/reperfusion injury through down-regulation of Toll-like receptor 4 signaling in rats.	Vitamin D	4-13	toll-like receptor 4	Rattus norvegicus	110-130
28261302-10	2017	CONCLUSIONS: The vitamin D analogue paricalcitol attenuates hepatic I/R injury through down-regulation of the TLR4 signaling pathway and might be considered to be a potential nutritional therapeutic agent against I/R injury in the liver.	Vitamin D	17-26	toll-like receptor 4	Rattus norvegicus	110-114
27987058-5	2017	Vitamin D significantly attenuated the MPTP-induced loss of tyrosine hydrlase (TH)-positive neuronal cells, microglial cell activation (Iba1-immunoreactive), inducible nitric oxide synthase (iNOS) and TLR-4 expression, typical hallmarks of the pro-inflammatory (M1) activation of microglia.	Vitamin D	0-9	nitric oxide synthase 2, inducible	Mus musculus	158-189
27987058-5	2017	Vitamin D significantly attenuated the MPTP-induced loss of tyrosine hydrlase (TH)-positive neuronal cells, microglial cell activation (Iba1-immunoreactive), inducible nitric oxide synthase (iNOS) and TLR-4 expression, typical hallmarks of the pro-inflammatory (M1) activation of microglia.	Vitamin D	0-9	nitric oxide synthase 2, inducible	Mus musculus	191-195
27987058-5	2017	Vitamin D significantly attenuated the MPTP-induced loss of tyrosine hydrlase (TH)-positive neuronal cells, microglial cell activation (Iba1-immunoreactive), inducible nitric oxide synthase (iNOS) and TLR-4 expression, typical hallmarks of the pro-inflammatory (M1) activation of microglia.	Vitamin D	0-9	toll-like receptor 4	Mus musculus	201-206
28377587-0	2017	Overexpression of GSN could decrease inflammation and apoptosis in EAE and may enhance vitamin D therapy on EAE/MS.	Vitamin D	87-96	gelsolin	Rattus norvegicus	18-21
28377587-3	2017	Vitamin D is proven to have a therapeutic effect on MS/EAE; however, we previously found that vitamin D caused a downregulation of GSN, which might limit vitamin D efficacy.	Vitamin D	94-103	gelsolin	Rattus norvegicus	131-134
28377587-3	2017	Vitamin D is proven to have a therapeutic effect on MS/EAE; however, we previously found that vitamin D caused a downregulation of GSN, which might limit vitamin D efficacy.	Vitamin D	154-163	gelsolin	Rattus norvegicus	131-134
28377587-4	2017	In our current research, we obtained a better symptom and a slowing down progression in EAE after combining vitamin D treatment with a proper increase of GSN.	Vitamin D	108-117	gelsolin	Rattus norvegicus	154-157
28377587-5	2017	Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line).	Vitamin D	49-58	gelsolin	Rattus norvegicus	62-65
28377587-7	2017	Collectively, these results support the therapeutic effect of GSN in EAE, which might enhance Vitamin D therapy in EAE/MS.	Vitamin D	94-103	gelsolin	Rattus norvegicus	62-65
28095046-12	2017	The vitamin D composite score was associated with serum PTH, but this association was similar to that observed with 25(OH) D alone.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	56-59
28130180-8	2017	CONCLUSION: The threshold for 25OHD at the point of maximal suppression of PTH estimated in this study was lower than the suggested threshold of vitamin D deficiency in the literature, perhaps due to race or assay differences, and the relationship between vitamin D and PTH changed with sex and age.	Vitamin D	256-265	parathyroid hormone	Homo sapiens	75-78
28178628-1	2017	Previous publications widely reported that 25-hydroxyvitamin D-1-alpha-hydroxylase (CYP27B1) regulated the metabolism of 25-hydroxyvitamin D3, which has a close association between altered activity of vitamin D and vascular calcification has been reported in various human diseases, including chronic kidney disease, osteoporosis and atherosclerosis.	Vitamin D	53-62	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	84-91
28236062-8	2017	IGF-1correlates positively with serum vitamin D, BMI, and BMD.	Vitamin D	38-47	insulin like growth factor 1	Homo sapiens	0-5
28033130-0	2017	The effect of vitamin D on renin-angiotensin system activation and blood pressure: a randomized control trial.	Vitamin D	14-23	renin	Homo sapiens	27-32
27977406-11	2017	CONCLUSIONS: These discordant findings suggest a differential effect of vitamin D on cardiovascular risk factors such as oxidative stress and insulin resistance.	Vitamin D	72-81	insulin	Homo sapiens	142-149
27997353-1	2017	BACKGROUND: The association of low serum 25 hydroxy cholecalciferol (25OHD) levels with high glucose level and diminished insulin sensitivity suggests that vitamin D (VD) may modulate insulin metabolism.	Vitamin D	156-165	insulin	Homo sapiens	122-129
27997353-1	2017	BACKGROUND: The association of low serum 25 hydroxy cholecalciferol (25OHD) levels with high glucose level and diminished insulin sensitivity suggests that vitamin D (VD) may modulate insulin metabolism.	Vitamin D	156-165	insulin	Homo sapiens	184-191
28491910-6	2017	Even for patients with vitamin D deficiency, a significant proportion had PTH, normal calcium, phosphate, and alkaline phosphatase levels.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	74-77
28491910-7	2017	For patients with vitamin D &lt;25 nmol/L, 62.7% had a PTH within reference range, 83.1% had normal serum-adjusted calcium, 80.6% had normal phosphate, and 85.1% had a normal serum alkaline phosphatase.	Vitamin D	18-27	parathyroid hormone	Homo sapiens	55-58
27714313-5	2017	There are several shared effects of vitamin D and UVR on T cells including inhibition of proliferation and suppression of IFN-gamma and IL-17 producing T cells.	Vitamin D	36-45	interferon gamma	Homo sapiens	122-131
27714313-6	2017	Conversely UVR decreases and vitamin D increases IL-4 production from T cells.	Vitamin D	29-38	interleukin 4	Homo sapiens	49-53
28278285-2	2017	The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
28316773-6	2017	We co-administered the hormonally active form of vitamin D, 1alpha,25 dihydroxy vitamin D3 (1,25OHD), simultaneously with poly(I:C) and examined (i) social interaction, stereotyped behavior, emotional learning and memory, and innate anxiety-like behavior in juveniles and (ii) the levels of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha in maternal plasma and fetal brains.	Vitamin D	49-58	interleukin 1 beta	Mus musculus	322-330
28316773-6	2017	We co-administered the hormonally active form of vitamin D, 1alpha,25 dihydroxy vitamin D3 (1,25OHD), simultaneously with poly(I:C) and examined (i) social interaction, stereotyped behavior, emotional learning and memory, and innate anxiety-like behavior in juveniles and (ii) the levels of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha in maternal plasma and fetal brains.	Vitamin D	49-58	interleukin 6	Mus musculus	332-336
28316773-6	2017	We co-administered the hormonally active form of vitamin D, 1alpha,25 dihydroxy vitamin D3 (1,25OHD), simultaneously with poly(I:C) and examined (i) social interaction, stereotyped behavior, emotional learning and memory, and innate anxiety-like behavior in juveniles and (ii) the levels of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha in maternal plasma and fetal brains.	Vitamin D	49-58	tumor necrosis factor	Mus musculus	341-350
27553017-2	2017	Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	164-183
28012697-4	2017	The expression of LL-37 can be regulated by various endogenous factors including the active form of vitamin D (25(OH)D3).	Vitamin D	100-109	cathelicidin antimicrobial peptide	Homo sapiens	18-23
28063629-0	2017	The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis.	Vitamin D	36-45	zinc finger MIZ-type containing 1	Homo sapiens	25-30
28127831-3	2017	Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis.	Vitamin D	0-9	insulin	Homo sapiens	107-114
27977320-1	2017	Context: The vitamin D receptor (VDR) and enzymes involved in activation (CYP2R1, CYP27B1) and inactivation (CYP24A1) of vitamin D are expressed in ovary, testes, and spermatozoa.	Vitamin D	13-22	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	82-89
28382079-0	2017	The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level.	Vitamin D	25-34	C-reactive protein	Homo sapiens	89-107
28429558-2	2017	Supplementation may improve some biochemical parameters, such as reducing PTH levels in patients to CKD-stage 4 who have vitamin D deficiency; but it remains to be established whether the role of nutritional vitamin D in maintaining bone health in the general population can be extrapolated to the CKD population.	Vitamin D	121-130	parathyroid hormone	Homo sapiens	74-77
28236844-9	2017	Vitamin D [1,25(OH)2D3] is known to induce the CBS gene expression while it can suppress the oxidative stress-induced COX-2 up-regulation and thromboxane production.	Vitamin D	0-9	cystathionine beta-synthase	Homo sapiens	47-50
28236844-9	2017	Vitamin D [1,25(OH)2D3] is known to induce the CBS gene expression while it can suppress the oxidative stress-induced COX-2 up-regulation and thromboxane production.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	118-123
28143686-0	2017	Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3.	Vitamin D	0-9	C-reactive protein	Rattus norvegicus	56-74
28143686-7	2017	Administration of vitamin D in combination with HFD significantly decreased BW gain, decreased the serum levels of both calcium and CRP, increased the serum level of IL-10, improved the general histological appearance of the spleen, and decreased the expression of both CD86 and caspase-3 in the spleen in comparison with results seen in the HFD-C group.	Vitamin D	18-27	C-reactive protein	Rattus norvegicus	132-135
28196884-5	2017	Namely, Jak/Stat, Erk/Mapk, and Pi3K/Akt/mTor signaling pathway genes were down-regulated upon vitamin D supplementation.	Vitamin D	95-104	Eph receptor B1	Rattus norvegicus	18-21
28378123-2	2017	The accumulation of phosphate, the increased FGF23 levels, the reduction in active vitamin D production, and the tendency to hypocalcemia are persistent stimuli for the development and progression of parathyroid hyperplasia with increased secretion of PTH.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	252-255
28196884-5	2017	Namely, Jak/Stat, Erk/Mapk, and Pi3K/Akt/mTor signaling pathway genes were down-regulated upon vitamin D supplementation.	Vitamin D	95-104	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
28275670-1	2017	The data presented in this article are related to the research article entitled "The autoimmune risk gene ZMIZ1 is a vitamin D responsived marker of a molecular phenotype of multiple sclerosis" Fewings et al.	Vitamin D	117-126	zinc finger MIZ-type containing 1	Homo sapiens	106-111
28052885-3	2017	Studies evaluating the effect of milk fortification on iron and vitamin D status in these children are scarce.	Vitamin D	64-73	Weaning weight-maternal milk	Bos taurus	33-37
27919752-6	2017	An increment of PTH level, along with reduced bioavailable 25(OH)D levels, was evident when the bioavailable 25(OH)D level was &lt;5ng/mL, which may be the optimal cutpoint for sufficient vitamin D in Chinese elderly women.	Vitamin D	188-197	parathyroid hormone	Homo sapiens	16-19
27696351-10	2017	Vitamin D deficiency was most prevalent at Poundbury Camp (CPR 18.8%), vitamin C deficiency was identified more frequently in rural settlements (CPR 5.9%).	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	53-57
28063949-0	2017	Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice.	Vitamin D	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	78-83
28063949-8	2017	This study demonstrates a novel molecular mechanism by which vitamin-D can prevent oxidative stress and upregulates glucose uptake via SIRT1/AMPK/IRS1/GLUT4 cascade in HG-treated adipocytes and in adipose tissue of HFD diabetic mice.	Vitamin D	61-70	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	151-156
27796814-14	2017	Interleukin-8 may be an important mediator for hepatic fibrosis in nonalcoholic fatty liver disease patients with low vitamin D status.	Vitamin D	118-127	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
26603433-6	2017	Another pooled analysis of the 3 case-control studies demonstrated significantly lower circulating vitamin D (25-hydroxyvitamin D) levels (SMD, -0.25; 95% CI, -0.50 to -0.01; P=0.04) in patients with AAA than subjects without AAA.	Vitamin D	99-108	small nuclear ribonucleoprotein polypeptide N	Homo sapiens	139-142
28457030-2	2017	However, no study is available in India where the role of vitamin D supplementation in patients with hyporesponsiveness to increased doses of erythropoietin is available.	Vitamin D	58-67	erythropoietin	Homo sapiens	142-156
27618536-14	2017	Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 and increased transcription of the catabolic gene CYP24A1 observed.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	101-108
27535551-4	2017	Furthermore, raising serum calcium levels in Cyp27b1-depleted mice directly increased FGF23 levels and indirectly enhanced the action of ambient vitamin D metabolites via the vitamin D receptor.	Vitamin D	145-154	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	45-52
27535551-6	2017	Conditional osteoblastic deletion of Cyp27b1 caused lower serum FGF23 levels, despite normal circulating levels of vitamin D metabolites.	Vitamin D	115-124	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	37-44
28025137-2	2017	It is formed by the hydroxylation of vitamin D at the 1alpha position by 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1) in the kidney.	Vitamin D	37-46	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	113-120
28087005-2	2017	Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism.	Vitamin D	219-228	adiponectin, C1Q and collagen domain containing	Homo sapiens	172-183
27254743-4	2017	Total E-cadherin expression increased by 7% (P = 0.35) for vitamin D versus no vitamin D, 8% (P = 0.31) for calcium versus no calcium, and 12% (P = 0.21) for vitamin D + calcium versus calcium.	Vitamin D	59-68	cadherin 1	Homo sapiens	6-16
27254743-4	2017	Total E-cadherin expression increased by 7% (P = 0.35) for vitamin D versus no vitamin D, 8% (P = 0.31) for calcium versus no calcium, and 12% (P = 0.21) for vitamin D + calcium versus calcium.	Vitamin D	79-88	cadherin 1	Homo sapiens	6-16
27254743-4	2017	Total E-cadherin expression increased by 7% (P = 0.35) for vitamin D versus no vitamin D, 8% (P = 0.31) for calcium versus no calcium, and 12% (P = 0.21) for vitamin D + calcium versus calcium.	Vitamin D	79-88	cadherin 1	Homo sapiens	6-16
27254743-5	2017	These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, beta-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	31-40	cadherin 1	Homo sapiens	114-124
27254743-5	2017	These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, beta-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	31-40	cadherin 1	Homo sapiens	346-356
27179106-0	2017	Vitamin D treatment for connective tissue diseases: hope beyond the hype?	Vitamin D	0-9	FIC domain protein adenylyltransferase	Homo sapiens	68-72
28272298-2	2017	Vitamin D supplementation typically leads to the reductions in serum parathyroid hormone (PTH) levels, as shown in normal weight individuals.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	69-88
28025137-12	2017	Using Cyp27b1-/- mice produced in this study, we can analyze the physiological effects of novel vitamin D derivatives in the absence of endogenous 1alpha,25D3.	Vitamin D	96-105	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	6-13
28107527-1	2017	The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1).	Vitamin D	18-27	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	76-83
28400827-8	2017	The mean of HbA1c and insulin was increased significantly both in Vitamin D-treated and placebo-treated groups (P &lt; 0.05).	Vitamin D	66-75	insulin	Homo sapiens	22-29
28122601-12	2017	CONCLUSIONS: The loss of muscle mass in slow muscles in the absence of vitamin D signaling is due to elevated levels of phosphorylated Stat3 that leads to an increase in Myostatin signaling, which in turn decreases protein synthesis and fiber size through the phosphorylation of p70S6K and rpS6, respectively.	Vitamin D	71-80	signal transducer and activator of transcription 3	Mus musculus	135-140
27733274-1	2017	HYPOTHESIS: Phosphorus and vitamin D (calcitriol) supplementation in the Phex mouse, a murine model for endolymphatic hydrops (ELH), will improve otic capsule mineralization and secondarily ameliorate the postnatal development of ELH and sensorineural hearing loss (SNHL).	Vitamin D	27-36	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	73-77
28086755-8	2017	The strength of evidence that serious vitamin D deficiency increases the risk of developing dementia, however, is very low due to the observational nature of included studies and their lack of adjustment for residual or important confounders (e.g. ApoE epsilon4 genotype), as well as the indirect relationship between Vitamin D concentrations as a surrogate for sunlight exposure and dementia risk.	Vitamin D	38-47	apolipoprotein E	Homo sapiens	248-252
28101293-0	2017	Establishing the prevalence of low vitamin D in non-immunoglobulin-E mediated gastrointestinal food allergic children in a tertiary centre.	Vitamin D	35-44	immunoglobulin heavy constant epsilon	Homo sapiens	48-68
28101293-2	2017	The aims of our study were to understand the prevalence of vitamin D insufficiency and deficiency in children with non-IgE mediated gastrointestinal food allergy and identify predisposing factors.	Vitamin D	59-68	immunoglobulin heavy constant epsilon	Homo sapiens	119-122
28101293-12	2017	CONCLUSIONS: Children with non-IgE mediated gastrointestinal food allergy are at risk of vitamin D insufficiency and deficiency.	Vitamin D	89-98	immunoglobulin heavy constant epsilon	Homo sapiens	31-34
27880946-2	2017	DP001 is an oral vitamin D analog that suppresses parathyroid hormone (PTH) in uremic rats, osteopenic women, and hemodialysis patients.	Vitamin D	17-26	parathyroid hormone	Rattus norvegicus	50-69
28395329-12	2017	These results suggest that upregulation of eNOSSer1177 and AktSer473 phosphorylation and inhibition of ROCK1 cleavage in EC and modulation of eNOS and caveolin-1 expression in MP could be plausible mechanisms of vitamin D protective effects on ECs.	Vitamin D	212-221	nitric oxide synthase 3	Homo sapiens	43-47
27792863-12	2017	Serum vitamin D was inversely correlated with PTH (p &lt; 0.045).	Vitamin D	6-15	parathyroid hormone	Homo sapiens	46-49
28395329-12	2017	These results suggest that upregulation of eNOSSer1177 and AktSer473 phosphorylation and inhibition of ROCK1 cleavage in EC and modulation of eNOS and caveolin-1 expression in MP could be plausible mechanisms of vitamin D protective effects on ECs.	Vitamin D	212-221	caveolin 1	Homo sapiens	151-161
28910170-1	2017	We investigated the protective effect of vitamin D against liver damage caused by carbon tetrachloride (CCl4).	Vitamin D	41-50	C-C motif chemokine ligand 4	Rattus norvegicus	104-108
28473985-10	2017	However, calcium and ALP levels showed a significant positive (p &lt; 0.05) and negative (p &lt; 0.001) correlation with vitamin D, respectively.	Vitamin D	121-130	alkaline phosphatase, placental	Homo sapiens	21-24
28286758-5	2017	Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration.	Vitamin D	0-9	insulin	Homo sapiens	184-191
28817810-0	2017	TGF-beta1 is Involved in Vitamin D-Induced Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Regulating the ERK/JNK Pathway.	Vitamin D	25-34	transforming growth factor, beta 1	Rattus norvegicus	0-9
29382525-1	2017	BACKGROUND: Low levels of vitamin D have been associated with a range of clinical conditions such as obesity, insulin resistance, and diabetes mellitus, among others.	Vitamin D	26-35	insulin	Homo sapiens	110-117
29382525-9	2017	A significant association between low levels of active vitamin D and high levels of insulin was found.	Vitamin D	55-64	insulin	Homo sapiens	84-91
28620554-1	2017	We present the clinical phenotype of a toddler who presented with vitamin D-resistant rickets, with one of the highest initial levels of alkaline phosphatase and parathyroid hormone (PTH) levels reported in the literature.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	162-181
28620554-1	2017	We present the clinical phenotype of a toddler who presented with vitamin D-resistant rickets, with one of the highest initial levels of alkaline phosphatase and parathyroid hormone (PTH) levels reported in the literature.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	183-186
28817810-0	2017	TGF-beta1 is Involved in Vitamin D-Induced Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Regulating the ERK/JNK Pathway.	Vitamin D	25-34	Eph receptor B1	Rattus norvegicus	136-139
28817810-7	2017	After stable transfection, the effects of aberrantly expressed TGF-beta1 on vitamin D-induced alterations, including BMSC viability, migration and chondrogenic differentiation, were all evaluated utilizing CCK-8 assay, Transwell assay, qRT-PCR and Western blot analysis.	Vitamin D	76-85	transforming growth factor, beta 1	Rattus norvegicus	63-72
28817810-10	2017	These alterations of BMSCs induced by vitamin D were reinforced by TGF-beta1 overexpression while were reversed by TGF-beta1 silencing.	Vitamin D	38-47	transforming growth factor, beta 1	Rattus norvegicus	67-76
28817810-13	2017	TGF-beta1 might be implicated in the vitamin D-induced alterations of BMSCs through regulating ERK/JNK pathway.	Vitamin D	37-46	transforming growth factor, beta 1	Rattus norvegicus	0-9
28817810-13	2017	TGF-beta1 might be implicated in the vitamin D-induced alterations of BMSCs through regulating ERK/JNK pathway.	Vitamin D	37-46	Eph receptor B1	Rattus norvegicus	95-98
29074823-4	2017	The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D].	Vitamin D	39-48	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-136
29179169-5	2017	In this review, I will discuss about the roles of Enpp1 in regulating the FGF23-Klotho-vitamin D axis and bones.	Vitamin D	87-96	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	50-55
29074823-4	2017	The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D].	Vitamin D	167-176	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-136
29074836-3	2017	Parathyroid hormone(PTH)increases extracellular calcium concentration partly through the activation of vitamin D, and active vitamin D corrects hypocalcemia mainly by increasing intestinal calcium abosorption.	Vitamin D	103-112	parathyroid hormone	Homo sapiens	20-23
29074836-4	2017	PTH coordinately increases blood calcium level with vitamin D in bone and kidney, however, renal tubular reabsorption of calcium is regulated by PTH-dependent mechanism.	Vitamin D	52-61	parathyroid hormone	Homo sapiens	0-3
29200598-12	2017	In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.	Vitamin D	82-91	insulin	Homo sapiens	141-148
28872358-3	2017	Because vitamin D deficiency activates the renin-angiotensin-aldosterone system (RAAS), we hypothesized that this vitamin would interact with the RAAS to influence blood pressure (BP) in nondipper hypertensive patients.	Vitamin D	8-17	renin	Homo sapiens	43-48
27033542-7	2017	There was a statistically significant inverse correlation between vitamin D status [defined by quartiles of measured values as well as commonly accepted cutoffs of serum 25(OH)D] and severity of the disease, as reflected by higher PTH and BSAP, but not by meeting the latest guidelines for parathyroidectomy.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	231-234
28595559-1	2017	OBJECTIVE: The present research explored the relationship of vitamin D status with prolactin levels and adenoma size in female patients with newly diagnosed prolactinoma and determination of hypovitaminosis D prevalence among female patients with prolactinoma.	Vitamin D	61-70	prolactin	Homo sapiens	83-92
28595559-11	2017	Also vitamin D deficiency in prolactinoma patients associated with larger adenoma size and higher prolactin level.	Vitamin D	5-14	prolactin	Homo sapiens	29-38
27154872-5	2017	We also genotyped two common DBP polymorphisms (rs7041 and rs4588) likely to affect the affinity for and levels of vitamin D metabolites.	Vitamin D	115-124	D-box binding PAR bZIP transcription factor	Homo sapiens	29-32
28241127-5	2017	We found that vitamin D upregulated pattern recognition receptors, TLR2, and NOD2, and induced the antimicrobial human neutrophil peptides (HNP1-3) and LL-37, resulting in increased killing of pneumococci in a vitamin D receptor-dependent manner.	Vitamin D	14-23	toll like receptor 2	Homo sapiens	67-71
29333433-1	2017	Background: The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D.	Vitamin D	16-25	insulin	Homo sapiens	56-63
27554047-3	2017	Vitamin D (vitD) negatively regulates the renin-angiotensin system, binds to vitD receptors on cardiac myocytes, and has antioxidant properties that may ameliorate the inflammation and proarrhythmic substrate formation.	Vitamin D	0-9	renin	Homo sapiens	42-47
27623983-11	2017	In future studies, the mechanistic background of this association and the role of vitamin D in the regulation of HLA gene expression should be investigated.	Vitamin D	82-91	major histocompatibility complex, class II, DR beta 1	Homo sapiens	113-116
27287609-0	2017	A Case of Vitamin-D-Dependent Rickets Type 1A with Normal 1,25-Dihydroxyvitamin D Caused by Two Novel Mutations of the CYP27B1 Gene.	Vitamin D	10-19	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	119-126
27287609-1	2017	BACKGROUND: Vitamin-D-dependent rickets 1A (VDDR-1A) is caused by mutations of the renal CYP27B1 gene and is a rare form of rickets.	Vitamin D	12-21	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	89-96
28502503-6	2017	CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels.	Vitamin D	21-30	insulin	Homo sapiens	161-168
28502503-6	2017	CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels.	Vitamin D	21-30	insulin	Homo sapiens	213-220
28502503-6	2017	CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels.	Vitamin D	21-30	insulin	Homo sapiens	213-220
28241127-8	2017	Moreover, vitamin D lowered inflammatory cytokine production by infected neutrophils via IL-4 production and the induction of suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3, leading to the suppression of NF-kappaB signaling.	Vitamin D	10-19	interleukin 4	Homo sapiens	89-93
28458477-14	2017	Low Vitamin D levels were associated with high mean parathyroid hormone (PTH) levels statistically significant with P = 0.034.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	52-71
28331861-0	2017	The Effect of Vitamin D Administration on Intracellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 Levels in Hemodialysis Patients: A Placebo-controlled, Double-blinded Clinical Trial.	Vitamin D	14-23	vascular cell adhesion molecule 1	Homo sapiens	80-113
27060335-3	2017	Mutations in CYP27B1 cause 1alpha-hydroxylase deficiency, also known as vitamin D dependent rickets type I or hereditary pseudo-vitamin D deficient rickets; very rare mutations in CYP2R1 can cause 25-hydroxylase deficiency.	Vitamin D	72-81	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	13-20
27060335-3	2017	Mutations in CYP27B1 cause 1alpha-hydroxylase deficiency, also known as vitamin D dependent rickets type I or hereditary pseudo-vitamin D deficient rickets; very rare mutations in CYP2R1 can cause 25-hydroxylase deficiency.	Vitamin D	128-137	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	13-20
27060335-7	2017	Other pathways of vitamin D metabolism are under investigation, notably its 20-hydroxylation by the cholesterol side-chain cleavage enzyme, CYP11A1.	Vitamin D	18-27	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	140-147
29104377-13	2017	Vitamin D deficiency was correlated with TNF-alpha serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	41-50
27926633-7	2017	The average treatment effect with 95% confidence interval, for LDL-C, compared with placebo, was -1.6, (95% confidence interval [CI] -5.5 to 2.2) mg/dL for calcium+vitamin D alone, -9.0 (95% CI -13.0 to -5.1) mg/dL for hormone therapy alone, and -13.8 (95% CI -17.8 to -9.8) mg/dL for the combination.	Vitamin D	164-173	component of oligomeric golgi complex 2	Homo sapiens	63-68
28787727-5	2017	Using candidate gene approach, obesity- (insulin-like growth factor 2 (IGF2), proopiomelanocortin (POMC)) and vitamin D metabolism-related genes (1-alfa-hydroxylase (CYP27B1), VDR) regulated by DNA methylation were selected.	Vitamin D	110-119	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	166-173
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	interleukin 1 beta	Homo sapiens	332-340
28058015-9	2016	Thus, active vitamin D may enhance autophagy but suppress inflammatory IL-1beta expression in Salmonella-infected IECs.	Vitamin D	13-22	interleukin 1 beta	Homo sapiens	71-79
27977757-10	2016	CONCLUSION: DHA plus vitamin D treatment improved insulin-resistance, lipid profile, ALT and NAS.	Vitamin D	21-30	insulin	Homo sapiens	50-57
28028396-9	2016	At the same time, a significant positive correlation has been observed between vitamin D, thymosin beta4, and CD4 at (r = 0.719; P = 0.001), and (r = 0.559, P = 0.001) respectively.	Vitamin D	79-88	thymosin beta 4 X-linked	Homo sapiens	90-104
28028396-9	2016	At the same time, a significant positive correlation has been observed between vitamin D, thymosin beta4, and CD4 at (r = 0.719; P = 0.001), and (r = 0.559, P = 0.001) respectively.	Vitamin D	79-88	CD4 molecule	Homo sapiens	110-113
28028396-10	2016	CONCLUSION: We concluded that vitamin D may be an essential factor that influence or determine the level of thymosin beta4.	Vitamin D	30-39	thymosin beta 4 X-linked	Homo sapiens	108-122
28028396-11	2016	This study is the first that focused on demonstrating that sufficient level of vitamin D may have the ability to influence the thymic hormone thymosin beta4 levels.	Vitamin D	79-88	thymosin beta 4 X-linked	Homo sapiens	142-156
28028396-12	2016	Further studies on large scale of subjects are needed to explore the positive correlation we had found between vitamin D and thymosin beta4 and CD4.	Vitamin D	111-120	thymosin beta 4 X-linked	Homo sapiens	125-139
28028396-12	2016	Further studies on large scale of subjects are needed to explore the positive correlation we had found between vitamin D and thymosin beta4 and CD4.	Vitamin D	111-120	CD4 molecule	Homo sapiens	144-147
27973447-6	2016	Levels of HK19F-specific IFN-gamma were significantly higher (11.7-fold, p = 0.038) in vitamin D-insufficient adults (&lt;50 nmol/L) compared to sufficient adults (&gt;50 nmol/L).	Vitamin D	87-96	interferon gamma	Homo sapiens	25-34
27927221-3	2016	METHODS: We conducted a randomized, controlled clinical trial from July 2014 over 1 year, aiming to assess the changes in 25 (OH) D and biochemical outcome on calcium and PTH(parathyroid hormone) using 3 different regimens of vitamin D replacement.	Vitamin D	226-235	parathyroid hormone	Homo sapiens	175-194
27862673-0	2017	Vitamin D restores angiogenic balance and decreases tumor necrosis factor-alpha in a rat model of pre-eclampsia.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	52-79
27862673-7	2017	The vitamin D treatment group had significantly increased VEGF, and reduced sFlt-1 and TNF-alpha compared with the untreated PE group.	Vitamin D	4-13	tumor necrosis factor	Rattus norvegicus	87-96
28331861-4	2017	The goal of this study is to find the effect of Vitamin D administration on ICAM-1 and VCAM-1 serum levels in ESRD patients on hemodialysis.	Vitamin D	48-57	vascular cell adhesion molecule 1	Homo sapiens	87-93
27520301-11	2017	Some researchers reported also that vitamin D regulates the expression of the insulin sensitizing hormone, adiponectin.	Vitamin D	36-45	adiponectin, C1Q and collagen domain containing	Homo sapiens	107-118
28751822-0	2017	Vitamin D Deficiency Is Associated with Increased Osteocalcin Levels in Acute Aortic Dissection: A Pilot Study on Elderly Patients.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	50-61
27922682-2	2017	The 24-hydroxylase (CYP24A1) and 1-hydroxylase (CYP27B1) enzymes are considered to be pivotal determinants of the local concentration of active vitamin D.	Vitamin D	144-153	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	48-55
27922682-9	2017	Local alterations in the anabolism and catabolism of active vitamin D in breast cancer by the CYP27B1 and CYP24A1 may impair its anticancer functions.	Vitamin D	60-69	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	94-101
27926633-9	2017	CONCLUSION: Reductions in LDL-C were greater among women randomized to both calcium+vitamin D and hormone therapy than for those randomized to either intervention alone or to placebo.	Vitamin D	84-93	component of oligomeric golgi complex 2	Homo sapiens	26-31
33503783-0	2017	Vitamin D deficiency: A Public Health Issue in High- and Low-Income Countries or Just Hype?	Vitamin D	0-9	FIC domain protein adenylyltransferase	Homo sapiens	86-90
28033387-2	2016	The 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27B1) is integral to the vitamin D metabolic pathway.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	45-52
27161894-13	2016	CONCLUSIONS: Restoration of vitamin D status of patients undergoing dialysis promoted upregulation of CYP27B1 and VDR expression in monocytes and a decrease in circulating inflammatory markers.	Vitamin D	28-37	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	102-109
27696575-4	2016	The proportion of TNF-alpha-expressing Th cells was significantly higher in the vitamin D deficiency group (VDD) than in VDN (P&lt;.05).	Vitamin D	80-89	tumor necrosis factor	Homo sapiens	18-27
27271477-2	2016	The pathophysiology of cardiac syndrome X (CSX) involves many pathways that are influenced by vitamin D levels.	Vitamin D	94-103	NK2 homeobox 5	Homo sapiens	43-46
27271477-3	2016	This study aimed to investigate the relationship between vitamin D deficiency and abnormal blood pressure response to exercise in patients with CSX.	Vitamin D	57-66	NK2 homeobox 5	Homo sapiens	144-147
27717074-7	2016	Men with vitamin D deficiency or insufficiency effectively treated with vitamin D preparations were characterized by decreased insulin sensitivity and higher circulating levels of hsCRP, homocysteine, and fibrinogen in comparison with the remaining groups of patients.	Vitamin D	9-18	fibrinogen beta chain	Homo sapiens	205-215
27717074-7	2016	Men with vitamin D deficiency or insufficiency effectively treated with vitamin D preparations were characterized by decreased insulin sensitivity and higher circulating levels of hsCRP, homocysteine, and fibrinogen in comparison with the remaining groups of patients.	Vitamin D	72-81	fibrinogen beta chain	Homo sapiens	205-215
28027627-7	2016	Vitamin D deficiency may be associated with various risk factors for cardiovascular disease that are already manifested in childhood, including obesity, hypertension, dyslipidaemia, insulin resistance, and metabolic syndrome.	Vitamin D	0-9	insulin	Homo sapiens	182-189
27642128-2	2016	Research of past decades illustrated that vitamin D and E have a key role in the improvement of diabetes by reducing oxidative stress, protein glycosylation, insulin resistance and also improving beta cell function.	Vitamin D	42-51	insulin	Homo sapiens	158-165
27591823-1	2016	The purpose of this study was to identify if circulating interleukin (IL)-6 and gamma-tocopherol (gammaT) fluctuate with vitamin D status in subjects with an underlying knee joint injury or disease.	Vitamin D	121-130	interleukin 6	Homo sapiens	57-75
27813049-1	2016	The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues.	Vitamin D	63-72	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	102-109
27902451-3	2016	Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs.	Vitamin D	61-70	insulin	Homo sapiens	229-236
27902451-3	2016	Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs.	Vitamin D	61-70	renin	Homo sapiens	328-333
28111615-3	2016	Although data on the efficacy of vitamin D supplementation on Mycobacterium tuberculosis (Mtb) clearance is uncertain from randomized controlled trials (RCTs), vitamin D enhances the expression of the anti-microbial peptide human cathelicidin (hCAP18) in cultured macrophages in vitro.	Vitamin D	160-169	cathelicidin antimicrobial peptide	Homo sapiens	244-250
27353739-1	2016	Vitamin D-dependent rickets type 1A (VDDR-1A) (Online Mendelian Inheritance in Man #264700) is a rare, autosomal recessively inherited disorder due to inactivating mutations in CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	177-184
27798347-0	2016	Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study.	Vitamin D	21-30	C-reactive protein	Homo sapiens	143-161
27798347-11	2016	CONCLUSIONS: Our findings suggest that the associations between vitamin D status and CVD risk factors in AAs are partially mediated through circulating adipokines and CRP.	Vitamin D	64-73	C-reactive protein	Homo sapiens	167-170
27721113-10	2016	Our results suggest that the vitamin D-related genes RXRG and GC affect LDL-c levels.	Vitamin D	29-38	component of oligomeric golgi complex 2	Homo sapiens	72-77
27827962-2	2016	Nutritional vitamin D supplementation is used for additional local parathyroid (PTH) suppression, with lower incidence of hypercalcemia and hyperphosphatemia.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	80-83
27339172-2	2016	We report very high prevalence of vitamin D deficiency in a large database of Brazilian subjects and show seasonal and reciprocal relationship between vitamin D and parathyroid hormone (PTH) over the years in this tropical area.	Vitamin D	151-160	parathyroid hormone	Homo sapiens	165-184
27339172-2	2016	We report very high prevalence of vitamin D deficiency in a large database of Brazilian subjects and show seasonal and reciprocal relationship between vitamin D and parathyroid hormone (PTH) over the years in this tropical area.	Vitamin D	151-160	parathyroid hormone	Homo sapiens	186-189
27339172-13	2016	CONCLUSIONS: A sinusoidal interrelationship has been detected between vitamin D and PTH in this tropical population.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	84-87
27555076-0	2016	Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients.	Vitamin D	0-9	C-reactive protein	Homo sapiens	65-83
27555076-3	2016	OBJECTIVE: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients.	Vitamin D	63-72	C-reactive protein	Homo sapiens	122-140
28040129-10	2016	In the vitamin D group, only IL-6 levels were significantly decreased.	Vitamin D	7-16	interleukin 6	Rattus norvegicus	29-33
27429113-1	2016	Aim of this study was to evaluate the effect of vitamin D supplementation in obese, insulin resistant and vitamin D deficient PCOS women on biochemical and clinical hyperandrogenism and menstrual irregularity in comparison to effect of metformin or combined metformin plus vitamin D therapy.	Vitamin D	48-57	insulin	Homo sapiens	84-91
27827910-1	2016	The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease.	Vitamin D	27-36	C-reactive protein	Homo sapiens	40-58
27827910-1	2016	The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease.	Vitamin D	27-36	C-reactive protein	Homo sapiens	60-63
27558316-10	2016	Anti-inflammatory cytokine IL-10 had strong positive associations with vitamin D, purine, and vitamin E metabolism.	Vitamin D	71-80	interleukin 10	Mus musculus	27-32
27821403-10	2016	CONCLUSIONS: Vitamin D deficiency was associated with increased 6-year change in hs-cTnT levels.	Vitamin D	13-22	troponin T2, cardiac type	Homo sapiens	84-88
27357804-1	2016	The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3), has been reported to positively regulate the human cathelicidin anti-microbial peptide (CAMP) gene coding for LL-37, but the mechanisms are not completely understood.	Vitamin D	32-41	cathelicidin antimicrobial peptide	Homo sapiens	171-175
27357804-1	2016	The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3), has been reported to positively regulate the human cathelicidin anti-microbial peptide (CAMP) gene coding for LL-37, but the mechanisms are not completely understood.	Vitamin D	32-41	cathelicidin antimicrobial peptide	Homo sapiens	193-198
27689826-4	2016	AREAS COVERED: In 2015, the FDA (Food and Drug Administration) approved rhPTH (1-84), named Natpara , a bioengineered recombinant human PTH, for the management of hypoparathyroidism of any etiology, except Autosomal Dominant Hypocalcemia, not well controlled with calcium and active vitamin D.	Vitamin D	283-292	parathyroid hormone	Homo sapiens	74-77
27537278-7	2016	Recommendations for the treatment of obesity-related vitamin D deficiency should emphasize the role of visceral adiposity loss through healthy lifestyle habits, in conjunction with weight-adjusted vitamin D supplementation, not only to replenish 25(OH)D levels but also to address other visceral adiposity-related disturbances, such as insulin resistance, inflammation, hypertension, and dyslipidemia.	Vitamin D	53-62	insulin	Homo sapiens	336-343
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	197-203
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	CD4 molecule	Homo sapiens	67-70
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	CD4 molecule	Homo sapiens	150-153
27648718-2	2016	However, interventional studies demonstrating that vitamin D replacement reduces circulating renin-angiotensin-aldosterone components and improves vascular function in humans are still lacking.	Vitamin D	51-60	renin	Homo sapiens	93-98
27648718-11	2016	CONCLUSION: The restoration of normal vitamin D levels after 8-week cholecalciferol treatment is able to inhibit peripheral renin-angiotensin system and improve FMD in essential hypertensive patients with hypovitaminosis D.	Vitamin D	38-47	renin	Homo sapiens	124-129
26686945-6	2016	There was limited overlap between genetic determinants of vitamin D status and those associated with non-skeletal health outcomes: polymorphisms in DBP, CYP2R1 and DHCR7 were the most frequent to be reported to associate with circulating concentrations of 25(OH)D, while polymorphisms in VDR were most commonly reported to associate with non-skeletal health outcomes, among which infectious and autoimmune diseases were the most represented.	Vitamin D	58-67	D-box binding PAR bZIP transcription factor	Homo sapiens	148-151
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	D-box binding PAR bZIP transcription factor	Homo sapiens	214-217
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	230-237
27116295-12	2016	The negative association with serum PTH levels suggests that vitamin D supplementation partly improves secondary hyperparathyroidism, yet other mechanisms may contribute to low bone mass after bariatric surgery.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	36-39
27252374-7	2016	Vitamin D supplementation of the Ca and P deficient diet considerably augmented transcription of TLR2b, TLR4, CATH1, and CATHB1 and predominantly Th2 cytokines in spleen.	Vitamin D	0-9	toll like receptor 2	Gallus gallus	97-102
27327576-7	2016	Binary logistic regression analysis showed a strong association between the presence of vitamin D deficiency and benign prostatic hyperplasia (BPH) after adjusting for age, International Prostate Symptom Score, urination time, urinary volume, abdominal obesity, aldosterone, glucose, insulin, parathyroid hormone, and C-reactive protein (odds ratio 5.22, 95% confidence interval 1.96-12.76, P = .001).	Vitamin D	88-97	parathyroid hormone	Homo sapiens	293-312
27812706-8	2016	Higher CD4 counts were associated with higher vitamin D levels (P = 0.018).	Vitamin D	46-55	CD4 molecule	Homo sapiens	7-10
27812706-10	2016	In the multivariate analysis, the best ordinal logistic regression model had the CD4 count as predictor (P &lt; 0.005), higher CD4 counts were associated with decreased odds of vitamin D deficiency (odds ratio 0.47, 95% confidence interval 0.28-0.80).	Vitamin D	177-186	CD4 molecule	Homo sapiens	81-84
27812706-10	2016	In the multivariate analysis, the best ordinal logistic regression model had the CD4 count as predictor (P &lt; 0.005), higher CD4 counts were associated with decreased odds of vitamin D deficiency (odds ratio 0.47, 95% confidence interval 0.28-0.80).	Vitamin D	177-186	CD4 molecule	Homo sapiens	127-130
27327576-7	2016	Binary logistic regression analysis showed a strong association between the presence of vitamin D deficiency and benign prostatic hyperplasia (BPH) after adjusting for age, International Prostate Symptom Score, urination time, urinary volume, abdominal obesity, aldosterone, glucose, insulin, parathyroid hormone, and C-reactive protein (odds ratio 5.22, 95% confidence interval 1.96-12.76, P = .001).	Vitamin D	88-97	insulin	Homo sapiens	284-291
27327576-7	2016	Binary logistic regression analysis showed a strong association between the presence of vitamin D deficiency and benign prostatic hyperplasia (BPH) after adjusting for age, International Prostate Symptom Score, urination time, urinary volume, abdominal obesity, aldosterone, glucose, insulin, parathyroid hormone, and C-reactive protein (odds ratio 5.22, 95% confidence interval 1.96-12.76, P = .001).	Vitamin D	88-97	C-reactive protein	Homo sapiens	318-336
27554639-7	2016	A reduction in TAZ can also enhance the sensitivity of tumor cells to vitamin D by regulating the p53/CYP24A1 pathway.	Vitamin D	70-79	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	15-18
27554639-7	2016	A reduction in TAZ can also enhance the sensitivity of tumor cells to vitamin D by regulating the p53/CYP24A1 pathway.	Vitamin D	70-79	tumor protein p53	Homo sapiens	98-101
27803671-9	2016	We evaluated the molecular evidence that supports the epidemiological observation that both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.	Vitamin D	92-101	calcium sensing receptor	Homo sapiens	253-257
27795667-2	2016	In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37.	Vitamin D	25-34	cathelicidin antimicrobial peptide	Homo sapiens	109-114
27377727-5	2016	A decline in the vitamin D/Klotho/Nrf2 regulatory network may enhance the ageing process, and this is well illustrated by the age-related decline in cognition in rats that can be reversed by administering vitamin D.	Vitamin D	17-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
27716192-0	2016	Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.	Vitamin D	26-35	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-71
27435264-9	2016	In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression.	Vitamin D	31-40	PPARG coactivator 1 alpha	Homo sapiens	78-87
28222403-3	2016	At the same time vitamin D suppresses the expression of myostatin, a negative regulator of muscle mass.	Vitamin D	17-26	myostatin	Homo sapiens	56-65
26696653-2	2016	The purpose of this study was to evaluate the associations between vitamin D with bone health and parathyroid hormone (PTH) concentrations in female runners who trained at 30.4  degrees north.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	98-117
26696653-2	2016	The purpose of this study was to evaluate the associations between vitamin D with bone health and parathyroid hormone (PTH) concentrations in female runners who trained at 30.4  degrees north.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	119-122
27573000-0	2016	Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement.	Vitamin D	4-13	S100 calcium binding protein A7	Homo sapiens	83-89
26454858-10	2016	CONCLUSION: Vitamin D reposition with oral calcifediol, in a biweekly or monthly regimen, is safe and effective in improving 25(OH)D blood levels and in decreasing PTH in kidney transplant recipients.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	164-167
27107558-5	2016	An ~10-fold increase in ceruloplasmin and ~4-fold increase in haptoglobin gene expression suggested a possible association between vitamin D and iron homeostasis.	Vitamin D	131-140	haptoglobin	Homo sapiens	62-73
27154413-8	2016	A consensus sequence to the vitamin D responsive element (VDRE) was identified in silico in the SLC1A5 gene promoter, and site-directed mutagenesis analyses with reporter gene studies demonstrate a functional negative VDRE in the promoter of the SLC1A5 gene.	Vitamin D	28-37	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	96-102
27154413-8	2016	A consensus sequence to the vitamin D responsive element (VDRE) was identified in silico in the SLC1A5 gene promoter, and site-directed mutagenesis analyses with reporter gene studies demonstrate a functional negative VDRE in the promoter of the SLC1A5 gene.	Vitamin D	28-37	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	246-252
27174721-3	2016	This study is to determine whether vitamin D-mediated inhibition of cell proliferation is associated with JNK1 in colorectal cancer cells.	Vitamin D	35-44	mitogen-activated protein kinase 8	Homo sapiens	106-110
27692170-9	2016	Vitamin D has the potential to maintain the concentration of VEGF in the circulation and induce the function of endothelial cells.	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	61-65
27692170-11	2016	Our hypothesis shed light on the evidence based knowledge translation of plausible cellular phenomena due to vitamin D/VEGF homeostasis during valvular vandalism in RHD.	Vitamin D	109-118	vascular endothelial growth factor A	Homo sapiens	119-123
27865354-0	2016	Vitamin D supplementation reduces insulin resistance in Japanese adults: a secondary analysis of a double-blind, randomized, placebo-controlled trial.	Vitamin D	0-9	insulin	Homo sapiens	34-41
27865354-3	2016	The objective of this study was to assess the effect of vitamin D supplementation for 1 year on insulin resistance; the study was a secondary analysis of a clinical trial.	Vitamin D	56-65	insulin	Homo sapiens	96-103
27865354-11	2016	After vitamin D supplementation, fasting glucose levels and values of homeostasis model assessment of insulin resistance index significantly decreased from 88.3 to 85.3 mg/dL (P &lt; .01) and 1.17 to 0.84 (P &lt; .01), respectively, and the results were independent of physical activity and visceral fat accumulation.	Vitamin D	6-15	insulin	Homo sapiens	102-109
27865354-12	2016	In conclusion, the present study showed that vitamin D supplementation for 1 year effectively improves fasting glucose level and insulin resistance in healthy Japanese adults.	Vitamin D	45-54	insulin	Homo sapiens	129-136
27207502-13	2016	CONCLUSIONS: Our results, indicating the inhibition of cytokine levels and the regulation of claudin-2, claudin-4, and claudin-7 by 1,25(OH)2D3, suggest that vitamin D may represent a potential therapeutic agent for the treatment of active UC.	Vitamin D	158-167	claudin 2	Homo sapiens	93-102
27207502-13	2016	CONCLUSIONS: Our results, indicating the inhibition of cytokine levels and the regulation of claudin-2, claudin-4, and claudin-7 by 1,25(OH)2D3, suggest that vitamin D may represent a potential therapeutic agent for the treatment of active UC.	Vitamin D	158-167	claudin 4	Homo sapiens	104-113
27655266-13	2016	The induction of OVA-induced allergic airway disease itself had a profound affect on the OTUs identified in the lung microbiome, which was accompanied by substantially more respiratory inflammation than that induced by vitamin D deficiency alone.	Vitamin D	219-228	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	17-20
27632366-1	2016	The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species.	Vitamin D	82-91	solute carrier family 8 member A1	Canis lupus familiaris	178-182
27632366-1	2016	The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species.	Vitamin D	82-91	cytochrome P450 family 27 subfamily B member 1	Canis lupus familiaris	184-191
27632366-8	2016	All vitamin D responsive and calcium transporting transcripts were highly correlated with VDR in equine kidney, but not in sheep and dogs.	Vitamin D	4-13	vitamin D receptor	Equus caballus	90-93
27632366-11	2016	The findings suggest that despite low serum vitamin D concentrations, vitamin D still plays a significant role in calcium metabolism in horses, especially given the strong correlations between VDR and vitamin D responsive transcripts in these animals.	Vitamin D	70-79	vitamin D receptor	Equus caballus	193-196
27632366-11	2016	The findings suggest that despite low serum vitamin D concentrations, vitamin D still plays a significant role in calcium metabolism in horses, especially given the strong correlations between VDR and vitamin D responsive transcripts in these animals.	Vitamin D	70-79	vitamin D receptor	Equus caballus	193-196
27222384-2	2016	Previous studies suggest that vitamin D has a potential regulatory role in TGFbeta1 induced activation in bone formation, and there is cross-talk between their signaling pathways, but research on their effects in other types of wound healing is limited.	Vitamin D	30-39	transforming growth factor beta 1	Homo sapiens	75-83
27222384-3	2016	The authors therefore wanted to explore the role of vitamin D and its interaction with low concentration of TGFbeta1 in dermal fibroblast-mediated wound healing through an in vitro study.	Vitamin D	52-61	transforming growth factor beta 1	Homo sapiens	108-116
27222384-6	2016	Compared to either factor alone, treatment of fibroblasts with both vitamin D and low concentration of TGFbeta1 increased gene expression of TGFbeta1, connective tissue growth factor, and fibronectin 1, and enhanced fibroblast migration, myofibroblast formation, and collagen production.	Vitamin D	68-77	transforming growth factor beta 1	Homo sapiens	141-149
27222384-6	2016	Compared to either factor alone, treatment of fibroblasts with both vitamin D and low concentration of TGFbeta1 increased gene expression of TGFbeta1, connective tissue growth factor, and fibronectin 1, and enhanced fibroblast migration, myofibroblast formation, and collagen production.	Vitamin D	68-77	fibronectin 1	Homo sapiens	188-201
27561346-5	2016	However, even with concomitant administration of massive active vitamin D, the increase of intact PTH levels greater than 1000 pg/mL by this agent is not rare.	Vitamin D	64-73	parathyroid hormone	Homo sapiens	98-101
27833859-2	2016	Growing evidence indicates that vitamin D deficiency may be associated with inflammation, insulin resistance, and obesity.	Vitamin D	32-41	insulin	Homo sapiens	90-97
27374117-8	2016	Furthermore, vitamin D deficiency caused upregulation of the mRNA expression of tumor necrosis factor-alpha, hypoxia-inducible factor-1alpha and its downstream target lysyl oxidase in mesenteric PVAT.	Vitamin D	13-22	tumor necrosis factor	Mus musculus	80-107
27585197-2	2016	Deficiency of vitamin D was also shown to be associated with new onset atrial fibrillation (AF) by activating the renin-angiotensin system.	Vitamin D	14-23	renin	Homo sapiens	114-119
27692170-0	2016	Vitamin D regulates the production of vascular endothelial growth factor: A triggering cause in the pathogenesis of rheumatic heart disease?	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	38-72
26769066-8	2016	HLA-DRB1*15 status modified the association of vitamin D status (pixn = 0.022) with relapse rate (per 10 ng/mL, in DRB1*15+ hazard ratio (HR) = 0.72, 95% CI = 0.58-0.88, p = 0.002; in DRB1*15- HR = 0.96, 95% CI = 0.83-1.12, p = 0.64).	Vitamin D	47-56	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
26769066-8	2016	HLA-DRB1*15 status modified the association of vitamin D status (pixn = 0.022) with relapse rate (per 10 ng/mL, in DRB1*15+ hazard ratio (HR) = 0.72, 95% CI = 0.58-0.88, p = 0.002; in DRB1*15- HR = 0.96, 95% CI = 0.83-1.12, p = 0.64).	Vitamin D	47-56	major histocompatibility complex, class II, DR beta 1	Homo sapiens	4-8
26769066-8	2016	HLA-DRB1*15 status modified the association of vitamin D status (pixn = 0.022) with relapse rate (per 10 ng/mL, in DRB1*15+ hazard ratio (HR) = 0.72, 95% CI = 0.58-0.88, p = 0.002; in DRB1*15- HR = 0.96, 95% CI = 0.83-1.12, p = 0.64).	Vitamin D	47-56	major histocompatibility complex, class II, DR beta 1	Homo sapiens	115-119
26769066-10	2016	CONCLUSION: We demonstrate that HLA-DRB1*15 modifies the association of vitamin D status with relapse rate.	Vitamin D	72-81	major histocompatibility complex, class II, DR beta 1	Homo sapiens	32-40
27207502-5	2016	The aim of the study was to determine whether vitamin D could affect IL-13 and IL-6 levels, and regulate the activity of tight-junction proteins.	Vitamin D	46-55	interleukin 13	Homo sapiens	69-74
27207502-5	2016	The aim of the study was to determine whether vitamin D could affect IL-13 and IL-6 levels, and regulate the activity of tight-junction proteins.	Vitamin D	46-55	interleukin 6	Homo sapiens	79-83
27683096-5	2016	After withdrawal of the vitamin D analogue and initiation of daily hemodialysis, there was rapid dissolution of her tumoral calcium deposits with the abrupt onset of parathyroid hormone (PTH)-independent transient hypercalcemia that resolved once the soft tissue deposits disappeared.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	166-185
27790335-0	2016	The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes: a randomized double-blinded controlled trial.	Vitamin D	15-24	adiponectin, C1Q and collagen domain containing	Homo sapiens	44-55
27790335-0	2016	The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes: a randomized double-blinded controlled trial.	Vitamin D	15-24	insulin	Homo sapiens	66-73
27790335-1	2016	BACKGROUND: Despite the certain role of both vitamin D and adiponectin in the regulation of insulin sensitivity, the interaction between these two agents has remained uncertain.	Vitamin D	45-54	insulin	Homo sapiens	92-99
27790335-2	2016	OBJECTIVE: The present study aimed to determine whether vitamin D is able to change plasma adiponectin and affect glucose homeostasis and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes.	Vitamin D	56-65	adiponectin, C1Q and collagen domain containing	Homo sapiens	91-102
27790335-9	2016	CONCLUSION: This study showed that decreased insulin resistance is expected by administrating vitamin D supplement in first-degree relatives of the patients with diabetes mellitus.	Vitamin D	94-103	insulin	Homo sapiens	45-52
27526995-1	2016	The biological actions of vitamin D are largely mediated through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor family, which regulates gene expression in a wide variety of tissues and cells.	Vitamin D	26-35	vitamin D receptor a	Danio rerio	80-98
27526995-1	2016	The biological actions of vitamin D are largely mediated through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor family, which regulates gene expression in a wide variety of tissues and cells.	Vitamin D	26-35	vitamin D receptor a	Danio rerio	100-103
27679579-8	2016	Reduced levels of CaSR and reduced responsiveness to active vitamin D in parathyroid neoplasia and colon carcinoma may blunt the "tumor suppressor" activity of the CaSR.	Vitamin D	60-69	calcium sensing receptor	Homo sapiens	164-168
27620138-7	2016	Vitamin D blocked the increase of helper T-cell type 1 (Th1)- and helper T-cell type 17 (Th17)-related cytokines in TNBS-induced colitis.	Vitamin D	0-9	negative elongation factor complex member C/D, Th1l	Mus musculus	56-59
27496895-11	2016	Protein expression studies in human bronchial epithelial cells also showed that addition of vitamin D decreased MID1 expression.	Vitamin D	92-101	midline 1	Homo sapiens	112-116
27777911-0	2016	Long-term clinical outcome and the identification of homozygous CYP27B1 gene mutations in a patient with vitamin D hydroxylation-deficient rickets type 1A.	Vitamin D	105-114	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-71
27777911-1	2016	Vitamin D hydroxylation-deficient rickets type 1A (VDDR1A) is an autosomal recessively-inherited disorder caused by mutations in CYP27B1 encoding the 1alpha-hydroxylase enzyme.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-136
27269178-0	2016	Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture.	Vitamin D	0-9	interferon gamma	Homo sapiens	46-62
27269178-1	2016	OBJECTIVES: We aimed to investigate the influence of vitamin D on the production of the pro-inflammatory cytokine, interferon gamma (IFN-gamma), and the anti-inflammatory cytokine, interleukin-10 (IL-10), in peripheral blood mononuclear cell (PBMC) cultures.	Vitamin D	53-62	interferon gamma	Homo sapiens	115-142
27269178-7	2016	In culture, vitamin D inhibited IFN-gamma production and increased IL-10 production by PBMCs.	Vitamin D	12-21	interferon gamma	Homo sapiens	32-41
27269178-9	2016	CONCLUSIONS: This study demonstrates that vitamin D modulates IFN-gamma and IL-10 production and provides a rationale for evaluating vitamin D as an immunomodulatory agent.	Vitamin D	42-51	interferon gamma	Homo sapiens	62-71
27026421-16	2016	Supplementation of vitamin D, B12 and calcium resulted in higher serum levels of vitamins, lower PTH levels and diminished severe vitamin D deficiency and is thus recommended as standard care.	Vitamin D	19-28	parathyroid hormone	Homo sapiens	97-100
27026421-16	2016	Supplementation of vitamin D, B12 and calcium resulted in higher serum levels of vitamins, lower PTH levels and diminished severe vitamin D deficiency and is thus recommended as standard care.	Vitamin D	130-139	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	30-33
27588106-7	2016	Using ELISA kits, it was determined that insulin, homeostatic model assessment-insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation (P&lt;0.05).	Vitamin D	162-171	insulin	Homo sapiens	41-48
27588106-7	2016	Using ELISA kits, it was determined that insulin, homeostatic model assessment-insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation (P&lt;0.05).	Vitamin D	162-171	insulin	Homo sapiens	79-86
27588106-9	2016	In conclusion, high-dose vitamin D supplementation (50,000 IU every 2 weeks) significantly improved insulin resistance in pregnant women with GDM.	Vitamin D	25-34	insulin	Homo sapiens	100-107
26224363-0	2016	The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	38-57
27399352-0	2016	Vitamin D-Dependent Rickets Type 1 Caused by Mutations in CYP27B1 Affecting Protein Interactions With Adrenodoxin.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	58-65
27399352-2	2016	Vitamin D-dependent rickets type 1 (VDDR-1) is a rare autosomal recessive disorder caused by mutations in CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	106-113
27180929-0	2016	Vitamin D and its receptor regulate lipopolysaccharide-induced transforming growth factor-beta, angiotensinogen expression and podocytes apoptosis through the nuclear factor-kappaB pathway.	Vitamin D	0-9	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	96-111
27180929-5	2016	Transforming growth factor-beta and angiotensinogen levels originally elevated by lipopolysaccharide challenge were distinctly reduced after pre-incubation with vitamin D.	Vitamin D	161-170	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	36-51
27180929-12	2016	CONCLUSIONS: Vitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor-beta, angiotensinogen expression and apoptosis of podocytes.	Vitamin D	13-22	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	148-163
27430408-8	2016	Furthermore, vitamin D increased the mRNA expression levels of LC3 and Beclin 1, and increased Bcl-2 protein expression levels in STZ-treated MIN6 cells, while decreasing the apoptosis rate.	Vitamin D	13-22	B cell leukemia/lymphoma 2	Mus musculus	95-100
27672830-0	2016	Poster 61 Higher Dietary Intake of Vitamin D May Influence Cholesterol and Insulin Sensitivity Independent of Body Composition in Men with Chronic Spinal Cord Injury.	Vitamin D	35-44	insulin	Homo sapiens	75-82
27447175-4	2016	It was shown that human keratinocytes possess the enzymatic machinery (CYP27B1) for the synthesis of the biologically most active natural vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), representing an autonomous vitamin D3 pathway.	Vitamin D	138-147	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	71-78
27570748-1	2015	BACKGROUND: To investigate the effect of supplementation of standard treatment (inhaled long-acting beta2 agonists, anticholinergics and corticosteroids) with vitamin D on C reactive protein and pulmonary function tests in patients with COPD exacerbation.	Vitamin D	159-168	C-reactive protein	Homo sapiens	172-190
27519883-2	2016	The aim of this study was to investigate whether serum vitamin D levels were associated with various metabolic diseases including insulin resistance (IR), metabolic syndrome (MS), fatty liver (FL), and coronary artery calcification (CAC), along with assessing gender differences for these relationships in Korean adults.	Vitamin D	55-64	insulin	Homo sapiens	130-137
27377727-4	2016	This regulatory role of vitamin D is supported by both Klotho and Nrf2.	Vitamin D	24-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-70
27377727-5	2016	A decline in the vitamin D/Klotho/Nrf2 regulatory network may enhance the ageing process, and this is well illustrated by the age-related decline in cognition in rats that can be reversed by administering vitamin D.	Vitamin D	205-214	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
27042750-10	2016	Vitamin D sufficiency may be required to obtain optimal effects of GH treatment on bone quality, as assessed by TBS, in GHD adults.	Vitamin D	0-9	growth hormone 1	Homo sapiens	67-69
26873242-0	2016	The effect of a single dose of vitamin D on glycemic status and C-reactive protein levels in type 2 diabetic patients with ischemic heart disease: a randomized clinical trial.	Vitamin D	31-40	C-reactive protein	Homo sapiens	64-82
27130351-6	2016	However, deletion or mutation of the predicted PXR-binding site abolished VitD3-mediated SULT1C2 transcriptional activation, identifying the site as a functional vitamin D response element (VDRE).	Vitamin D	162-171	nuclear receptor subfamily 1 group I member 2	Homo sapiens	47-50
27579147-7	2016	Bioinformatic analysis revealed multiple candidate genes for both PTH and vitamin D, including CUBN, MGAT3, and NFKBIA.	Vitamin D	74-83	NFKB inhibitor alpha	Homo sapiens	112-118
27413130-0	2016	Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial.	Vitamin D	10-19	insulin	Homo sapiens	46-53
27260305-4	2016	DAF-12 is related to the vitamin D, liver-X, and androstane receptors, and like these human receptors, it responds to lipophilic hormone ligands.	Vitamin D	25-34	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	0-6
27364912-3	2016	In this study, we explored the effect of two forms of vitamin D, a nutraceutical, on glycation modification in HSA.	Vitamin D	54-63	albumin	Homo sapiens	111-114
27364912-7	2016	Interaction studies reveal that Vitamin D interaction with HSA can prevent protein glycation.	Vitamin D	32-41	albumin	Homo sapiens	59-62
27496946-2	2016	SUMMARY ANSWER: Infertile men with vitamin D deficiency had lower sperm motility, total numbers of motile sperm, Inhibin B, sex-hormone-binding-globulin (SHBG) and testosterone/estradiol ratio, but higher levels of free sex steroids, than infertile men with normal vitamin D levels.	Vitamin D	35-44	sex hormone binding globulin	Homo sapiens	124-152
27496946-2	2016	SUMMARY ANSWER: Infertile men with vitamin D deficiency had lower sperm motility, total numbers of motile sperm, Inhibin B, sex-hormone-binding-globulin (SHBG) and testosterone/estradiol ratio, but higher levels of free sex steroids, than infertile men with normal vitamin D levels.	Vitamin D	35-44	sex hormone binding globulin	Homo sapiens	154-158
27490534-4	2016	The induction of CYP450 isoenzymes may cause vitamin D deficiency, hypocalcemia, increased fracture risks, and altered bone turnover, leading to impaired bone mineral density (BMD).	Vitamin D	45-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-23
32699567-3	2016	In this study, we characterize the effects of vitamin D-deficiency and sufficiency on the cutaneous expression of TREM-1, TREM-2, VDR, HMGB1, and RAGE.	Vitamin D	46-55	triggering receptor expressed on myeloid cells 2	Sus scrofa	122-128
32699567-3	2016	In this study, we characterize the effects of vitamin D-deficiency and sufficiency on the cutaneous expression of TREM-1, TREM-2, VDR, HMGB1, and RAGE.	Vitamin D	46-55	vitamin D receptor	Sus scrofa	130-133
32699567-3	2016	In this study, we characterize the effects of vitamin D-deficiency and sufficiency on the cutaneous expression of TREM-1, TREM-2, VDR, HMGB1, and RAGE.	Vitamin D	46-55	high mobility group protein B1	Sus scrofa	135-140
32699567-6	2016	In vitamin D-sufficient animals, keratinocytes exhibited elevated levels of TREM-1, TREM-2.	Vitamin D	3-12	triggering receptor expressed on myeloid cells 2	Sus scrofa	84-90
27010646-4	2016	INTRODUCTION: The relationship between bone quality parameters and vitamin D (Vit-D) status remains undefined among adolescents.	Vitamin D	67-76	vitrin	Homo sapiens	78-81
27540461-16	2016	CONCLUSION: These results suggest that daily vitamin D supplementation may ameliorate CVD risk factors including a decrease in 11beta-HSD1 activity, as evidenced by the decrease in the cortisol/cortisone ratio, and improve exercise performance in healthy individuals.	Vitamin D	45-54	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	127-138
27471592-2	2016	The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process.	Vitamin D	67-76	S100 calcium binding protein G	Homo sapiens	241-244
27547395-6	2016	Mean daily total dietary intakes of Fe, Zn, vitamin A and vitamin D were significantly higher in the fortified milk group.	Vitamin D	58-67	Weaning weight-maternal milk	Bos taurus	111-115
27471592-2	2016	The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process.	Vitamin D	67-76	S100 calcium binding protein G	Homo sapiens	246-259
27133915-5	2016	The combination of vitamin D &amp; resveratrol completely reversed tunicamycin and Abeta25-35 induced cytotoxicity in SH-SY5Y cells, as well as elevation in ER stress markers (i.e.GRP78, p-eIF2alpha and CHOP), insulin signaling disruption (i.e. elevation in p-IRS-1serine307 and reduction in p-Akt serine473) and tau phosphorylation (i.e. reduction in p-GSK3beta serine9, and elevation in p-Tau serine396 &amp;404).	Vitamin D	19-28	heat shock protein family A (Hsp70) member 5	Homo sapiens	180-185
27456232-0	2016	Vitamin D intervention in preschoolers with viral-induced asthma (DIVA): a pilot randomised controlled trial.	Vitamin D	0-9	BCL2 like 10	Homo sapiens	66-70
27649525-2	2016	The enzyme that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1, likewise is widely expressed in many cells of the body.	Vitamin D	50-59	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	87-94
27437780-0	2016	Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women.	Vitamin D	35-44	serpin family A member 12	Homo sapiens	67-73
27437780-3	2016	The aim of the present study is to investigate how vitamin D levels affect serum vaspin and omentin levels.	Vitamin D	51-60	serpin family A member 12	Homo sapiens	81-87
27392908-1	2016	BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before.	Vitamin D	12-21	cathelicidin antimicrobial peptide	Homo sapiens	91-96
27392908-1	2016	BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before.	Vitamin D	26-35	cathelicidin antimicrobial peptide	Homo sapiens	91-96
31149107-2	2016	We aim to assess relationship of vitamin D, B12, and folic acid levels and dietary vitamin intake and insulin resistance in obese people.	Vitamin D	33-42	insulin	Homo sapiens	102-109
31149107-14	2016	Conclusions: The study reveals that vitamin D, B12, and folic acid levels were low and poor vitamin D and B12 status were associated with insulin resistance in nondiabetic obese patients.	Vitamin D	92-101	insulin	Homo sapiens	138-145
27437780-6	2016	Relation of vitamin D with serum vaspin and omentin levels was determined in these groups.	Vitamin D	12-21	serpin family A member 12	Homo sapiens	33-39
27437780-12	2016	The results of this study suggested that there was a significant, positive correlation between serum vitamin D levels and vaspin, whereas a significant, negative correlation between vitamin D levels and omentin.	Vitamin D	101-110	serpin family A member 12	Homo sapiens	122-128
27133915-5	2016	The combination of vitamin D &amp; resveratrol completely reversed tunicamycin and Abeta25-35 induced cytotoxicity in SH-SY5Y cells, as well as elevation in ER stress markers (i.e.GRP78, p-eIF2alpha and CHOP), insulin signaling disruption (i.e. elevation in p-IRS-1serine307 and reduction in p-Akt serine473) and tau phosphorylation (i.e. reduction in p-GSK3beta serine9, and elevation in p-Tau serine396 &amp;404).	Vitamin D	19-28	DNA damage inducible transcript 3	Homo sapiens	203-207
27133915-5	2016	The combination of vitamin D &amp; resveratrol completely reversed tunicamycin and Abeta25-35 induced cytotoxicity in SH-SY5Y cells, as well as elevation in ER stress markers (i.e.GRP78, p-eIF2alpha and CHOP), insulin signaling disruption (i.e. elevation in p-IRS-1serine307 and reduction in p-Akt serine473) and tau phosphorylation (i.e. reduction in p-GSK3beta serine9, and elevation in p-Tau serine396 &amp;404).	Vitamin D	19-28	insulin	Homo sapiens	210-217
27306067-15	2016	Vitamin D may have a limited effect on CD8+ T cells by decreasing interferon-gamma expression.	Vitamin D	0-9	interferon gamma	Homo sapiens	66-82
26293661-1	2016	This study investigated the protective effect of vitamin D against carbon tetrachloride (CCl4)-induced nephrotoxicity in rats.	Vitamin D	49-58	C-C motif chemokine ligand 4	Rattus norvegicus	89-93
28514126-8	2016	One of the latest hypotheses regarding the involvement of haptoglobin in the development of diabetic complications is its contribution to impaired vitamin D activation in the kidney.	Vitamin D	147-156	haptoglobin	Homo sapiens	58-69
26260151-0	2016	Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	47-66
27514770-5	2016	Parathyroid hormone was inversely correlated with vitamin D level in both seasons (r = -0.044, P &lt; .001).	Vitamin D	50-59	parathyroid hormone	Homo sapiens	0-19
27488327-10	2016	The mean fold change in hCAP18 gene expression in Vitamin D group was significantly higher than placebo group.	Vitamin D	50-59	cathelicidin antimicrobial peptide	Homo sapiens	24-30
26466946-0	2016	The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.	Vitamin D	124-133	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	86-93
27512288-1	2016	[Purpose] The effects of vitamin D on the circulating levels of IL-17 and IL-13 were investigated in patients with diabetic peripheral neuropathy, patients with diabetes mellitus type 2 without neuropathy, and healthy controls.	Vitamin D	25-34	interleukin 13	Homo sapiens	74-79
27512288-10	2016	[Conclusion] Vitamin D is a potential modifiable risk factor for diabetic peripheral neuropathy and may regulate inflammatory mediators, e.g., IL-17 and IL-13.	Vitamin D	13-22	interleukin 13	Homo sapiens	153-158
27488327-12	2016	CONCLUSION: Decreases in ESR and hs-CRP levels and increase in LL37 gene expression support the hypothesis that Vitamin D supplementation may have a beneficial role in UC patients.	Vitamin D	112-121	cathelicidin antimicrobial peptide	Homo sapiens	63-67
27382252-0	2016	MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells.	Vitamin D	29-38	septin 4	Homo sapiens	0-4
26853879-0	2016	Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	38-41
26853879-5	2016	Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	44-47
27277007-14	2016	In addition, we express caution in using daily supplementation with a high vitamin D dose to improve vitamin D status and decrease parathyroid hormone.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	131-150
28149047-12	2016	The results of the present study clearly demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders.	Vitamin D	83-92	interferon alpha 1	Homo sapiens	119-122
27314328-5	2016	All of the tested vitamin D analogues upregulated CDH1, the gene encoding E-cadherin associated with epithelial phenotype.	Vitamin D	18-27	cadherin 1	Homo sapiens	50-54
27314328-5	2016	All of the tested vitamin D analogues upregulated CDH1, the gene encoding E-cadherin associated with epithelial phenotype.	Vitamin D	18-27	cadherin 1	Homo sapiens	74-84
27272805-6	2016	C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol.	Vitamin D	272-281	C-reactive protein	Homo sapiens	0-18
27271180-12	2016	Vitamin D supplementation significantly decreased serum levels of TNF-alpha and IFN-gamma, upregulated serum levels of IL-10, and had no effect on serum IL-6 levels.	Vitamin D	0-9	IL10	Sus scrofa	119-124
27272805-6	2016	C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol.	Vitamin D	272-281	interleukin 6	Homo sapiens	29-42
27272805-6	2016	C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol.	Vitamin D	272-281	interleukin 6	Homo sapiens	44-48
26279316-13	2016	Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D levels (p&lt;0.0001), and was accompanied by a reduction in parathyroid hormone concentrations (p=0.032).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	136-155
26725707-12	2016	PTH levels differed marginally (P = 0 0759) due to tendency to lowering immediately after vitamin D boluses.	Vitamin D	90-99	parathyroid hormone	Homo sapiens	0-3
27153206-11	2016	Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.	Vitamin D	115-124	insulin	Homo sapiens	144-151
26890031-0	2016	Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial.	Vitamin D	83-92	insulin	Homo sapiens	62-69
26890031-2	2016	The aim of the present study was to determine the effect of vitamin D supplementation on markers of insulin sensitivity and inflammation in men without diabetes with vitamin D deficiency/insufficiency.	Vitamin D	60-69	insulin	Homo sapiens	100-107
26890031-8	2016	Vitamin D supplementation administered for 12 months in healthy men maintained insulin levels and HOMA-IR values relative to the increase in the control group.	Vitamin D	0-9	insulin	Homo sapiens	79-86
29219782-12	2016	Similarly a decrease in TNF-alpha and IL-6 levels were also observed after vitamin D treatment.	Vitamin D	75-84	tumor necrosis factor	Mus musculus	24-33
27119753-0	2016	Tumoral Vitamin D Synthesis by CYP27B1 1-alpha-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-kappaB Modulation.	Vitamin D	8-17	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	31-38
27119753-1	2016	Biologically active vitamin D (1,25-dihydroxycholecalciferol or 1,25(OH)2D) is synthetized from inactive prohormone 25-hydroxycholecalciferol (25(OH)D) by the enzyme CYP27B1 1-alpha-hydroxylase in kidney and several extrarenal tissues including breast.	Vitamin D	20-29	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	166-173
29219782-12	2016	Similarly a decrease in TNF-alpha and IL-6 levels were also observed after vitamin D treatment.	Vitamin D	75-84	interleukin 6	Mus musculus	38-42
29469682-3	2016	AIM: A randomized double blind placebo controlled study to evaluate effects of vitamin D supplementation on insulin resistance in subjects with hypovitaminosis-D and MetS.	Vitamin D	79-88	insulin	Homo sapiens	108-115
27312912-1	2016	Management of secondary hyperparathyroidism (SHPT) in dialysis population includes the use of active vitamin D forms, among which paricalcitol was shown to be more effective at reducing parathyroid hormone (PTH) concentrations.	Vitamin D	101-110	parathyroid hormone	Homo sapiens	186-205
26938200-9	2016	The recent availability of recombinant human PTH (1-84) has given hope that management of hypoparathyroidism with the missing hormone in this disorder will provide better control and reduced needs for calcium and vitamin D.	Vitamin D	213-222	parathyroid hormone	Homo sapiens	45-48
27247730-0	2016	Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial.	Vitamin D	11-20	C-reactive protein	Homo sapiens	65-68
27247730-2	2016	This study evaluated the effect of vitamin D supplementation on metabolic indices and hs-C-reactive protein (CRP) levels in GDM patients.	Vitamin D	35-44	C-reactive protein	Homo sapiens	86-107
27250744-1	2016	Studies using vitamin D-binding protein (DBP) concentrations to estimate free and bioavailable vitamin D have increased dramatically in recent years.	Vitamin D	14-23	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
27250744-11	2016	Future studies of DBP and free or bioavailable vitamin D metabolites should employ DBP assays that are not biased by DBP genotype.	Vitamin D	47-56	D-box binding PAR bZIP transcription factor	Homo sapiens	83-86
27250744-11	2016	Future studies of DBP and free or bioavailable vitamin D metabolites should employ DBP assays that are not biased by DBP genotype.	Vitamin D	47-56	D-box binding PAR bZIP transcription factor	Homo sapiens	83-86
27170258-10	2016	For vitamin D insufficiency, the highest RR was again for men 1.31 (1.06, 1.61); obese subjects 1.57 (1.17, 2.11); and subjects who exercised 0-1/2 hours a week 1.51 (1.11, 2.06).	Vitamin D	4-13	menin 1	Homo sapiens	58-63
27001565-0	2016	Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein.	Vitamin D	15-24	C-reactive protein	Homo sapiens	92-110
27001565-8	2016	A lower vitamin D was associated with the blood draw during fall/winter months (P &lt; .001), older age (P = .001), increased CRP (P &lt; .001), increased tumor thickness (P &lt; .001), ulcerated tumor (P = .0105), and advanced melanoma stage (P = .0024).	Vitamin D	8-17	C-reactive protein	Homo sapiens	126-129
27001565-10	2016	The effect of vitamin D on these outcome measures persisted after adjustment for CRP and other covariates.	Vitamin D	14-23	C-reactive protein	Homo sapiens	81-84
27001565-13	2016	Although lower vitamin D was strongly associated with higher CRP, the associations of lower vitamin D with poorer OS, MSS, and DFS were independent of this association.	Vitamin D	15-24	C-reactive protein	Homo sapiens	61-64
27026514-0	2016	Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma.	Vitamin D	64-73	complement C3d receptor 2	Homo sapiens	43-47
27160686-1	2016	BACKGROUND: Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibility to active tuberculosis (TB) in the UK, but this phenomenon has not been investigated in settings with a high TB burden.	Vitamin D	77-86	D-box binding PAR bZIP transcription factor	Homo sapiens	137-140
27245104-2	2016	Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	54-61
26991835-2	2016	The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	140-147
27245104-2	2016	Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D.	Vitamin D	130-139	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	54-61
25376616-0	2016	The Effect of Vitamin D Supplementation on Thrombin Generation Assessed by the Calibrated Automated Thrombogram.	Vitamin D	14-23	coagulation factor II, thrombin	Homo sapiens	43-51
27023469-4	2016	Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three factors have been implicated in prostate cancer.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	60-79
25376616-2	2016	This study aimed to examine the relationship between vitamin D supplementation and thrombin generation.	Vitamin D	53-62	coagulation factor II, thrombin	Homo sapiens	83-91
26510652-1	2016	PURPOSE: A defect in a phosphate-regulating gene leads to the most common form of rickets: X-linked hypophosphatemic rickets (XLH) or vitamin D-resistant rickets (VDDR).	Vitamin D	134-143	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	163-167
27041081-6	2016	Both forms of vitamin D reduced the expression of pathogenic Th17 markers and their secretion of pro-inflammatory cytokines (IL-17A, IFN-gamma).	Vitamin D	14-23	interferon gamma	Homo sapiens	133-142
26778547-0	2016	The association between vitamin D and C-reactive protein levels in patients with inflammatory and non-inflammatory diseases.	Vitamin D	24-33	C-reactive protein	Homo sapiens	38-56
26778547-7	2016	RESULTS: The correlation between (log) ln-25(OH) vitamin D and ln-CRP was highly significant (p&lt;0.001) with a regression coefficient of -0.879.	Vitamin D	49-58	C-reactive protein	Homo sapiens	66-69
26695721-12	2016	The associations of maternal 25(OH)D levels with childhood eGFR were partly explained by childhood vitamin D status.	Vitamin D	99-108	epidermal growth factor receptor	Homo sapiens	59-63
26650177-6	2016	In case-only analyses, vitamin D metabolism and signaling pathways were associated with ER- cancer (pathway-level p = 0.02), driven by a single gene CASR (gene-level p = 0.001).	Vitamin D	23-32	estrogen receptor 1	Homo sapiens	88-90
27212156-2	2016	The immune modulator properties of vitamin D are mediated in part through effects on regulatory T cells (T-reg).	Vitamin D	35-44	regenerating family member 1 alpha	Homo sapiens	85-88
27212156-3	2016	Currently, in psoriasis, the relationship between vitamin D and T-reg has not well elucidated.	Vitamin D	50-59	regenerating family member 1 alpha	Homo sapiens	66-69
27212156-4	2016	We assess whether vitamin D status is correlated with circulating T-reg in patients affected by psoriasis and if there is a correlation with the severity of the disease evaluated with Psoriasis Area Severity Index (PASI) score.	Vitamin D	18-27	regenerating family member 1 alpha	Homo sapiens	68-71
27212156-9	2016	Using no parametric Spearman"s Coefficient test between serum levels of vitamin D and the single variables, we found an association with T-reg population (p &lt; 0.001) and with PASI-score (p = 0.04).	Vitamin D	72-81	regenerating family member 1 alpha	Homo sapiens	139-142
27212156-11	2016	Low levels of vitamin-D may decrease the number of circulatory T-reg, disrupting the immunological homeostasis in psoriatic patients and encouraging the inflammatory activity.	Vitamin D	14-23	regenerating family member 1 alpha	Homo sapiens	65-68
26873590-10	2016	In non-users of supplemental vitamin D, after adjustment for age and gender, negative associations were found for severe polypharmacy, metformin, sulphonamides and urea derivatives (SUDs), vitamin K antagonists, cardiac glycosides, loop diuretics, potassium-sparing diuretics, ACE inhibitors, and serotonin reuptake inhibitors; for non-selective monoamine reuptake inhibitors (NSMRIs) the association was positive.	Vitamin D	29-38	angiotensin I converting enzyme	Homo sapiens	277-280
26818421-1	2016	BACKGROUND: The importance of vitamin D in inflammatory bowel disease (IBD) has been analyzed in former studies, namely concerning the severity of the disease and the efficacy of anti-tumor necrosis factor (TNF) medications.	Vitamin D	30-39	tumor necrosis factor	Homo sapiens	179-205
26818421-1	2016	BACKGROUND: The importance of vitamin D in inflammatory bowel disease (IBD) has been analyzed in former studies, namely concerning the severity of the disease and the efficacy of anti-tumor necrosis factor (TNF) medications.	Vitamin D	30-39	tumor necrosis factor	Homo sapiens	207-210
26818421-4	2016	We aimed to evaluate the clinical importance of the link between vitamin D, ANA, and anti-TNF in patients with IBD.	Vitamin D	65-74	tumor necrosis factor	Homo sapiens	90-93
26818421-10	2016	Pretreatment positivity for ANA and extreme vitamin D deficiency were significant risk factors for adverse events associated with anti-TNF therapy.	Vitamin D	44-53	tumor necrosis factor	Homo sapiens	135-138
26650177-6	2016	In case-only analyses, vitamin D metabolism and signaling pathways were associated with ER- cancer (pathway-level p = 0.02), driven by a single gene CASR (gene-level p = 0.001).	Vitamin D	23-32	calcium sensing receptor	Homo sapiens	149-153
26650177-9	2016	In addition, CASR may be related to tumor ER status, supporting a role of vitamin D or calcium in modifying breast cancer phenotypes.	Vitamin D	74-83	calcium sensing receptor	Homo sapiens	13-17
26970587-4	2016	CYP3A4 is the major drug-metabolising P450 in liver endoplasmic reticulum and can metabolise other active forms of vitamin D, so we examined its ability to metabolise 20(OH)D3.	Vitamin D	115-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
27196318-10	2016	Quantitative (q)PCR confirmed the vitamin D-mediated upregulation of target genes, including nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha).	Vitamin D	34-43	NFKB inhibitor alpha	Homo sapiens	93-176
27196318-10	2016	Quantitative (q)PCR confirmed the vitamin D-mediated upregulation of target genes, including nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha).	Vitamin D	34-43	NFKB inhibitor alpha	Homo sapiens	178-190
27196318-11	2016	In addition to increased transcript levels, IkappaBalpha protein was increased by 28% following 24 hours of vitamin D treatment.	Vitamin D	108-117	NFKB inhibitor alpha	Homo sapiens	44-56
27196318-12	2016	CONCLUSIONS: Microarray analysis demonstrates that vitamin D regulates numerous genes in HCEC and influences TLR signaling through upregulation of IkappaBalpha.	Vitamin D	51-60	NFKB inhibitor alpha	Homo sapiens	147-159
27091752-1	2016	AIM: Effects of vitamin D supplementation on the glycaemic indices and insulin resistance in diabetic and non-diabetic patients were studied.	Vitamin D	16-25	insulin	Homo sapiens	71-78
27091752-11	2016	Fasting plasma adiponectin levels increased significantly in the vitamin D group (p = 0.007), but not in the placebo group (p = 0.38).	Vitamin D	65-74	adiponectin, C1Q and collagen domain containing	Homo sapiens	15-26
27091752-13	2016	CONCLUSION: Vitamin D supplementation showed positive effect on plasma adiponectin level, as a biomarker of insulin sensitivity in surgical critically ill patients with stress-induced hyperglycaemia.	Vitamin D	12-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	71-82
27091752-13	2016	CONCLUSION: Vitamin D supplementation showed positive effect on plasma adiponectin level, as a biomarker of insulin sensitivity in surgical critically ill patients with stress-induced hyperglycaemia.	Vitamin D	12-21	insulin	Homo sapiens	108-115
27437203-11	2016	Another relevant finding was significant correlation of Vitamin D with insulin and Homeostatic Model of Assessment- Insulin Resistance Index (HOMA-IR).	Vitamin D	56-65	insulin	Homo sapiens	71-78
27437203-11	2016	Another relevant finding was significant correlation of Vitamin D with insulin and Homeostatic Model of Assessment- Insulin Resistance Index (HOMA-IR).	Vitamin D	56-65	insulin	Homo sapiens	116-123
27038530-6	2016	In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95%CI: -0.69, 1.19; p=0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95%CI: -0.15, 0.12; p=0.780).	Vitamin D	75-84	adiponectin, C1Q and collagen domain containing	Homo sapiens	38-49
26733373-1	2016	UNLABELLED: A normal reference value of parathyroid hormone (PTH) was established for the first time in a large sample of healthy Chinese subjects by completely excluding interference of vitamin D deficiency.	Vitamin D	187-196	parathyroid hormone	Homo sapiens	40-59
26733373-1	2016	UNLABELLED: A normal reference value of parathyroid hormone (PTH) was established for the first time in a large sample of healthy Chinese subjects by completely excluding interference of vitamin D deficiency.	Vitamin D	187-196	parathyroid hormone	Homo sapiens	61-64
27175089-7	2016	However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-alpha and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D.	Vitamin D	43-52	tumor necrosis factor	Homo sapiens	137-146
27146620-1	2016	OBJECTIVES: To evaluate the association of vitamin D level with insulin resistance, among healthy student"s obese women, and to identify factors that may elucidate this association.	Vitamin D	43-52	insulin	Homo sapiens	64-71
27215235-8	2016	We also analyzed the relationship between Vitamin D level and hemoglobin and erythropoietin dosage.	Vitamin D	42-51	erythropoietin	Homo sapiens	77-91
27175089-7	2016	However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-alpha and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D.	Vitamin D	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
27175089-7	2016	However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-alpha and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D.	Vitamin D	243-252	C-reactive protein	Homo sapiens	62-65
27175089-8	2016	Further, the anti-inflammatory/proinflammatory ratios suggest a role of vitamin D in maintaining an anti-inflammatory environment at low levels of CRP, an association that is weaker at high CRP levels in subjects with subclinical inflammatory situations.	Vitamin D	72-81	C-reactive protein	Homo sapiens	147-150
26843386-1	2016	Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD).	Vitamin D	6-15	parathyroid hormone	Homo sapiens	66-85
26893158-0	2016	Vitamin D attenuates inflammation in CFTR knockdown intestinal epithelial cells but has no effect in cells with intact CFTR.	Vitamin D	0-9	CF transmembrane conductance regulator	Homo sapiens	37-41
26893158-8	2016	Intriguingly, the anti-inflammatory effects of vitamin D metabolites were only observed in CFTR knockdown cells, which may be explained by alterations in its catabolism associated with changes in CYP24A1 expression.	Vitamin D	47-56	CF transmembrane conductance regulator	Homo sapiens	91-95
27103796-9	2016	The GC2 variant was a significant risk factor for vitamin D deficiency (odds ratio =2.41).	Vitamin D	50-59	solute carrier family 25 member 18	Homo sapiens	4-7
27103796-14	2016	CONCLUSION: The GC2 variant is a risk factor for vitamin D deficiency, and genotype 1F-1S is a protective factor against vitamin D deficiency.	Vitamin D	49-58	solute carrier family 25 member 18	Homo sapiens	16-19
26037530-1	2016	BACKGROUND: It has been suggested that polymorphisms in the WT1 gene modulate the effect of IFN-beta treatment in multiple sclerosis (MS) through regulation of the relationship between IFN-beta and vitamin D.	Vitamin D	198-207	WT1 transcription factor	Homo sapiens	60-63
26037530-2	2016	OBJECTIVE: To examine whether WT1 modulates the relationship between IFN-beta and vitamin D in a longitudinal study with repeated assessment of vitamin D before and after initiation of IFN-beta.	Vitamin D	82-91	WT1 transcription factor	Homo sapiens	30-33
26817629-8	2016	We demonstrate that vitamin D treatments decreased insulin resistance, reduced leptin, and increased adiponectin signaling and also regulated the LKB1/AMPK pathway contributing to an overall decrease in local estrogen synthesis in the obese mice.	Vitamin D	20-29	serine/threonine kinase 11	Mus musculus	146-150
26885880-2	2016	OBJECTIVE: The objective of this study was to determine the dose-response of vitamin D supplementation on fasting glucose, insulin, and a surrogate measure of insulin resistance in white and black children aged 9-13 years, who participated in the Georgia, Purdue, and Indiana University (or GAPI) trial: a 12-week multisite, randomized, triple-masked, dose-response, placebo-controlled vitamin D trial.	Vitamin D	77-86	insulin	Homo sapiens	123-130
26885880-2	2016	OBJECTIVE: The objective of this study was to determine the dose-response of vitamin D supplementation on fasting glucose, insulin, and a surrogate measure of insulin resistance in white and black children aged 9-13 years, who participated in the Georgia, Purdue, and Indiana University (or GAPI) trial: a 12-week multisite, randomized, triple-masked, dose-response, placebo-controlled vitamin D trial.	Vitamin D	77-86	insulin	Homo sapiens	159-166
27843822-9	2016	Deficiency of Vitamin D is commonly described as a cause for the bone loss in epileptic patients while others being decreased absorption of calcium, increased PTH levels, and inhibition of calcitonin secretion, etc.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	159-162
26694996-0	2016	Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway.	Vitamin D	39-48	insulin induced gene 2	Homo sapiens	117-124
26694996-0	2016	Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway.	Vitamin D	39-48	sterol regulatory element binding transcription factor 2	Homo sapiens	125-132
26694996-6	2016	Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased.	Vitamin D	6-15	insulin induced gene 2	Homo sapiens	133-155
26694996-6	2016	Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased.	Vitamin D	6-15	insulin induced gene 2	Homo sapiens	157-164
26694996-7	2016	Vitamin D3 was protective against vitamin D deficiency-induced cholesterol increase by maintaining the transcriptional activity of VDR and Insig-2 expression.	Vitamin D	34-43	insulin induced gene 2	Homo sapiens	139-146
27209698-10	2016	Overall, our data firstly showed that chronic calcitriol administration enhanced NRG1/ErbB signaling in the heart, indicating a novel mechanism underlying the cardiac effects of vitamin D.	Vitamin D	178-187	neuregulin 1	Rattus norvegicus	81-85
27679649-10	2016	CONCLUSIONS: Although the high vitamin D supplementation dose in the present study (compared to the 400 IU/day dose usually recommended for pregnancy) safely increases the serum 25OHD, in GDM cases, the higher dose does not affect the plasma glucose level or insulin resistance at short term follow-up after delivery.	Vitamin D	31-40	insulin	Homo sapiens	259-266
27094871-5	2016	The increased levels of vitamin D lead to significant changes in fasting insulin levels (6.8+-8.1 unit reduction versus 2.3+-3.7), a 2-h insulin (31.1+-34.9 unit reduction versus 4.5+-24.6) and Homeostasis Model Assessment (HOMA) indices.	Vitamin D	24-33	insulin	Homo sapiens	73-80
27094871-5	2016	The increased levels of vitamin D lead to significant changes in fasting insulin levels (6.8+-8.1 unit reduction versus 2.3+-3.7), a 2-h insulin (31.1+-34.9 unit reduction versus 4.5+-24.6) and Homeostasis Model Assessment (HOMA) indices.	Vitamin D	24-33	insulin	Homo sapiens	137-144
27094871-6	2016	CONCLUSION: Correction of vitamin D deficiency leads to increased insulin sensitivity that was significantly able to maintain glucose in the normal range with lower levels of insulin.	Vitamin D	26-35	insulin	Homo sapiens	66-73
27094871-6	2016	CONCLUSION: Correction of vitamin D deficiency leads to increased insulin sensitivity that was significantly able to maintain glucose in the normal range with lower levels of insulin.	Vitamin D	26-35	insulin	Homo sapiens	175-182
26876815-1	2016	The hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] induces cellular Ca2+ signals which regulate insulin secretion, while low vitamin D status may be a risk factor for type 2 diabetes (T2D).	Vitamin D	26-35	insulin	Homo sapiens	96-103
26876815-3	2016	In animal studies employing a high fat diet-induced obesity model of pre-T2D, an increased intake of vitamin D delayed development of T2D and adiposity and was associated with the improved blood markers of diabetes and the vitamin D nutritional and hormonal status [plasma concentrations of glucose, insulin, adiponectin, 25-hydroxyvitamin D, and 1,25(OH)2D3].	Vitamin D	101-110	insulin	Homo sapiens	300-307
26876815-3	2016	In animal studies employing a high fat diet-induced obesity model of pre-T2D, an increased intake of vitamin D delayed development of T2D and adiposity and was associated with the improved blood markers of diabetes and the vitamin D nutritional and hormonal status [plasma concentrations of glucose, insulin, adiponectin, 25-hydroxyvitamin D, and 1,25(OH)2D3].	Vitamin D	101-110	adiponectin, C1Q and collagen domain containing	Homo sapiens	309-320
26280673-0	2016	Vitamin D Induces Cyclooxygenase 2 Dependent Prostaglandin E2 Synthesis in HaCaT Keratinocytes.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34
26352089-0	2016	Low serum sclerostin levels in newborns with vitamin D deficiency.	Vitamin D	45-54	sclerostin	Homo sapiens	10-20
26352089-2	2016	The aim of this study was to investigate the association between neonatal vitamin D status and levels of circulating sclerostin.	Vitamin D	74-83	sclerostin	Homo sapiens	117-127
26352089-7	2016	Vitamin D deficient infants also had significantly lower serum sclerostin levels (188.4+-21.9 vs. 282.3+-30.4 pg/mL; p: 0.026) than vitamin D sufficient newborns at birth.	Vitamin D	0-9	sclerostin	Homo sapiens	63-73
26352089-9	2016	CONCLUSIONS: Our data also demonstrated that vitamin D deficient newborns exhibited lower sclerostin levels than vitamin D sufficient newborns.	Vitamin D	45-54	sclerostin	Homo sapiens	90-100
26352089-10	2016	The low sclerostin level might serve as a marker of decreased osteocyte activity in newborns with vitamin D deficiency.	Vitamin D	98-107	sclerostin	Homo sapiens	8-18
26704532-4	2016	The 25-hydroxylation involves mainly CYP2R1 and CYP27A1, whereas 1alpha-hydroxylation and 24-hydroxylation are catalyzed by CYP27B1 and CYP24A1, respectively, and are tightly regulated to maintain adequate levels of the active vitamin D hormone, 1alpha,25(OH)2D3.	Vitamin D	227-236	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	124-131
26408324-7	2016	RESULTS: After adjustment for potential confounders, the survivors who used vitamin D supplements had a better CCS score (subscale of FACT-C) over 24 months compared to non-users (beta = 1.28; 95 % CI 0.07-2.48).	Vitamin D	76-85	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	180-188
27031473-2	2016	Since vitamin D cleared brain Abeta in vitro, this 8-week trial examined whether vitamin D increased plasma Abeta40.	Vitamin D	6-15	amyloid beta precursor protein	Homo sapiens	30-35
27031473-6	2016	Thus, vitamin D may increase plasma Abeta, particularly in older adults, suggesting decreased brain Abeta.	Vitamin D	6-15	amyloid beta precursor protein	Homo sapiens	36-41
26843386-1	2016	Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD).	Vitamin D	6-15	parathyroid hormone	Homo sapiens	87-90
26981182-5	2016	Although in patients with DM the relationship between vitamin D and insulin secretion, insulin resistance, and beta-cell dysfunction are pointed out, evidence regarding vitamin D levels and DM is contradictory, and well controlled studies are needed.	Vitamin D	54-63	insulin	Homo sapiens	68-75
27065162-3	2016	PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion.	Vitamin D	8-17	parathyroid hormone	Homo sapiens	60-63
27065162-3	2016	PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion.	Vitamin D	8-17	parathyroid hormone	Homo sapiens	60-63
27065162-3	2016	PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion.	Vitamin D	92-101	parathyroid hormone	Homo sapiens	0-3
27065162-3	2016	PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion.	Vitamin D	92-101	parathyroid hormone	Homo sapiens	60-63
27065162-3	2016	PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion.	Vitamin D	92-101	parathyroid hormone	Homo sapiens	60-63
27065162-3	2016	PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion.	Vitamin D	132-141	parathyroid hormone	Homo sapiens	0-3
27027966-4	2016	We assessed the mechanisms by which Vit D modulates the enhancing effects of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and IL-13 on intracellular Ca(2+) ([Ca(2+)]i) levels and remodeling in nonasthmatic versus asthmatic human ASM.	Vitamin D	36-41	tumor necrosis factor	Homo sapiens	103-130
26959059-0	2016	The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus.	Vitamin D	35-44	insulin	Homo sapiens	56-63
26959059-1	2016	Vitamin D deficiency (i.e., hypovitaminosis D) is associated with increased insulin resistance, impaired insulin secretion, and poorly controlled glucose homeostasis, and thus is correlated with the risk of metabolic diseases, including type 2 diabetes mellitus (T2DM).	Vitamin D	0-9	insulin	Homo sapiens	76-83
26315471-0	2016	Vitamin D and its relation with ionic calcium, parathyroid hormone, maternal and neonatal characteristics in pregnancy after roux-en-Y gastric bypass.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	47-66
26315471-1	2016	PURPOSE: The objective of this study was to evaluate vitamin D nutritional status and its relation with ionic calcium, parathyroid hormone (PTH), maternal anthropometry and perinatal outcomes in pregnant women who previously underwent Roux-en-Y gastric bypass (RYGB) surgery.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	119-138
27027966-4	2016	We assessed the mechanisms by which Vit D modulates the enhancing effects of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and IL-13 on intracellular Ca(2+) ([Ca(2+)]i) levels and remodeling in nonasthmatic versus asthmatic human ASM.	Vitamin D	36-41	tumor necrosis factor	Homo sapiens	132-141
26724218-11	2016	Knowledge of the signaling pathways involved in the lipolytic action of PTH is important for our understanding of how metabolic derangements develop in states of hyperparathyroidism, including vitamin D deficiency.	Vitamin D	193-202	parathyroid hormone	Homo sapiens	72-75
27027966-4	2016	We assessed the mechanisms by which Vit D modulates the enhancing effects of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and IL-13 on intracellular Ca(2+) ([Ca(2+)]i) levels and remodeling in nonasthmatic versus asthmatic human ASM.	Vitamin D	36-41	interleukin 13	Homo sapiens	147-152
27076887-7	2016	RESULTS: Consumption of calcium-Vitamin D co-supplements resulted in a significant reduction of serum high-sensitivity C-reactive protein levels compared with placebo (-1856.8 +- 2657.7 vs. 707.1 +- 3139.4 mug/mL, P = 0.006).	Vitamin D	32-41	C-reactive protein	Homo sapiens	119-137
26308752-0	2016	Effect of vitamin D supplementation on insulin resistance and glycaemic control in prediabetes: a systematic review and meta-analysis.	Vitamin D	10-19	insulin	Homo sapiens	39-46
26308752-1	2016	AIMS: To evaluate the effect of vitamin D on insulin resistance and glycaemic control in prediabetes.	Vitamin D	32-41	insulin	Homo sapiens	45-52
26797277-3	2016	Vitamin D induces its genomic effects through its nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor a	Danio rerio	72-90
26462119-0	2016	FOXO1 Mediates Vitamin D Deficiency-Induced Insulin Resistance in Skeletal Muscle.	Vitamin D	15-24	insulin	Homo sapiens	44-51
26462119-1	2016	Prospective epidemiological studies have consistently shown a relationship between vitamin D deficiency, insulin resistance, and type 2 diabetes mellitus (DM2).	Vitamin D	83-92	insulin	Homo sapiens	105-112
26462119-2	2016	This is supported by recent trials showing that vitamin D supplementation in prediabetic or insulin-resistant patients with inadequate vitamin D levels improves insulin sensitivity.	Vitamin D	48-57	insulin	Homo sapiens	92-99
26462119-2	2016	This is supported by recent trials showing that vitamin D supplementation in prediabetic or insulin-resistant patients with inadequate vitamin D levels improves insulin sensitivity.	Vitamin D	48-57	insulin	Homo sapiens	161-168
26462119-2	2016	This is supported by recent trials showing that vitamin D supplementation in prediabetic or insulin-resistant patients with inadequate vitamin D levels improves insulin sensitivity.	Vitamin D	135-144	insulin	Homo sapiens	92-99
26462119-2	2016	This is supported by recent trials showing that vitamin D supplementation in prediabetic or insulin-resistant patients with inadequate vitamin D levels improves insulin sensitivity.	Vitamin D	135-144	insulin	Homo sapiens	161-168
26930567-5	2016	The active form of vitamin D (calcitriol) restored the SLE MAC phenotype towards that of healthy subjects with reduced IL-6 secretion, and normalised surface marker expression.	Vitamin D	19-28	interleukin 6	Homo sapiens	119-123
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	117-123
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	cytochrome P450 family 39 subfamily A member 1	Homo sapiens	267-274
26745256-1	2016	CONTEXT: Patients with 25-hydroxyvitamin D deficiency (25OHD &lt;20 ng/ml) and primary hyperparathyroidism (PHPT) have more severe disease reflected by higher serum PTH levels compared to those with vitamin D levels in the insufficient (20-29 ng/ml) or replete range (&gt;= 30 ng/ml).	Vitamin D	33-42	parathyroid hormone	Homo sapiens	165-168
26781763-1	2016	UNLABELLED: Limited data are available assessing the effects of vitamin D and evening primrose oil (EPO) administration on markers of insulin resistance and lipid concentrations in gestational diabetes mellitus (GDM).	Vitamin D	64-73	insulin	Homo sapiens	134-141
26781763-2	2016	This study was designed to evaluate the effects of vitamin D and EPO administration on insulin resistance and lipid concentrations among women with GDM.	Vitamin D	51-60	insulin	Homo sapiens	87-94
26797277-3	2016	Vitamin D induces its genomic effects through its nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor a	Danio rerio	92-95
26315479-4	2016	The frequencies of 6 common polymorphisms in the genes encoding the vitamin D synthesizing enzyme Cyp27b1 or the inactivating enzyme Cyp24a1 were assessed in 281 patients with AD and 278 healthy donors in a case-control setting.	Vitamin D	68-77	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	98-105
26304030-3	2016	CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPalpha) transcription factors.	Vitamin D	37-46	cathelicidin antimicrobial peptide	Homo sapiens	0-4
26585423-0	2016	Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	80-85
26304030-5	2016	Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPalpha.	Vitamin D	197-206	cathelicidin antimicrobial peptide	Homo sapiens	86-90
26304030-5	2016	Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPalpha.	Vitamin D	197-206	cathelicidin antimicrobial peptide	Homo sapiens	219-223
26304030-5	2016	Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPalpha.	Vitamin D	197-206	CCAAT enhancer binding protein alpha	Homo sapiens	233-243
26209260-10	2016	Serum vitamin D was positively associated with logarithmic transformed total IgE with base of 10 (LogTIgE) (coefficient (B), 0.011; 95% confidence interval, 0.001-0.021).	Vitamin D	6-15	immunoglobulin heavy constant epsilon	Homo sapiens	77-80
26130027-5	2016	Total BGP levels were twice as high with calcimimetics versus no calcimimetics (290 vs. 158.5 mcg/L, p &lt; 0.0001) and 69 % higher with vitamin D analogs (268 vs. 159 mcg/L, p &lt; 0.0001).	Vitamin D	137-146	bone gamma-carboxyglutamate protein	Homo sapiens	6-9
25727561-2	2016	Expression of the vitamin D receptor in diverse cell types (pancreatic islet cells, myocytes, hepatocytes and adipocytes) raises the suspicion that vitamin D may be involved in multiple cellular processes, including the response to insulin.	Vitamin D	18-27	insulin	Homo sapiens	232-239
26585423-4	2016	RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10(-7 )M, p&lt;0.01).	Vitamin D	98-107	cathelicidin antimicrobial peptide	Homo sapiens	7-12
26585423-7	2016	Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (p&lt;0.05).	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	64-69
26585423-9	2016	An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p&lt;0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37.	Vitamin D	163-172	cathelicidin antimicrobial peptide	Homo sapiens	46-51
26585423-9	2016	An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p&lt;0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37.	Vitamin D	163-172	cathelicidin antimicrobial peptide	Homo sapiens	198-203
26566633-10	2016	Vitamin D was significantly lower in ASCA positives (P = 0.044).Vitamin D showed positive correlation with IL-1beta (r 0.338, P &lt; 0.009) and negative correlation with VEGF (r -0.366, P &lt; 0.004).	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	170-174
26566633-10	2016	Vitamin D was significantly lower in ASCA positives (P = 0.044).Vitamin D showed positive correlation with IL-1beta (r 0.338, P &lt; 0.009) and negative correlation with VEGF (r -0.366, P &lt; 0.004).	Vitamin D	64-73	interleukin 1 beta	Homo sapiens	107-115
26566633-0	2016	Midkine in vitamin D deficiency and its association with anti-Saccharomyces cerevisiae antibodies.	Vitamin D	11-20	midkine	Homo sapiens	0-7
26566633-10	2016	Vitamin D was significantly lower in ASCA positives (P = 0.044).Vitamin D showed positive correlation with IL-1beta (r 0.338, P &lt; 0.009) and negative correlation with VEGF (r -0.366, P &lt; 0.004).	Vitamin D	64-73	vascular endothelial growth factor A	Homo sapiens	170-174
29052469-0	2016	Vitamin D and L-Isoleucine Promote Antimicrobial Peptide hBD-2 Production in Peripheral Blood Mononuclear Cells from Elderly Individuals.	Vitamin D	0-9	defensin beta 4A	Homo sapiens	57-62
26260969-2	2016	Lower vitamin D-binding protein (DBP) levels increase the biological availability of serum vitamin D.	Vitamin D	6-15	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
29052469-3	2016	L-isoleucine and vitamin D are important molecules that induce hBD-2.	Vitamin D	17-26	defensin beta 4A	Homo sapiens	63-68
26260969-11	2016	CONCLUSIONS: Polymorphisms associated with lower DBP level attenuated the association between low serum 25(OH)D3 level and food allergy, consistent with greater vitamin D bioavailability in those with a lower DBP level.	Vitamin D	161-170	D-box binding PAR bZIP transcription factor	Homo sapiens	49-52
29052469-4	2016	The Aim of this study was to determine the use L-isoleucine and Vitamin D to induce hBD-2 in cells from healthy elderly individuals and elderly individuals with recurrent infections.	Vitamin D	64-73	defensin beta 4A	Homo sapiens	84-89
26869438-5	2016	Specifically, CYP3A4 activity was increased up to 20-fold as compared to vitamin D treated wild-type Caco-2 cells.	Vitamin D	73-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
26653112-12	2016	CONCLUSIONS: In this ancillary study of a randomized controlled trial, we found that high-dose vitamin D3 significantly reduced CD4+ T-cell activation compared to low-dose vitamin D3, providing human evidence that vitamin D can influence cell-mediated immunity.	Vitamin D	95-104	CD4 molecule	Homo sapiens	128-131
26609167-0	2016	Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial.	Vitamin D	0-9	insulin	Homo sapiens	65-72
26343586-0	2016	Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-beta1 in ovariectomized rats.	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	90-99
26446269-0	2016	Adverse effects of vitamin D deficiency on the Pi3k/Akt pathway and pancreatic islet morphology in diet-induced obese mice.	Vitamin D	19-28	thymoma viral proto-oncogene 1	Mus musculus	52-55
26446064-1	2016	OBJECTIVE: To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.	Vitamin D	22-31	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	143-150
26676829-4	2016	The present study investigated whether vitamin D inhibits HCC via the regulation of HDAC2 and p21(WAF1/Cip1).	Vitamin D	39-48	histone deacetylase 2	Homo sapiens	84-89
26676829-4	2016	The present study investigated whether vitamin D inhibits HCC via the regulation of HDAC2 and p21(WAF1/Cip1).	Vitamin D	39-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-97
26676829-4	2016	The present study investigated whether vitamin D inhibits HCC via the regulation of HDAC2 and p21(WAF1/Cip1).	Vitamin D	39-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	98-102
26676829-4	2016	The present study investigated whether vitamin D inhibits HCC via the regulation of HDAC2 and p21(WAF1/Cip1).	Vitamin D	39-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	103-107
27904547-0	2016	The effect of vitamin D administration on serum leptin and adiponectin levels in end-stage renal disease patients on hemodialysis with vitamin D deficiency: A placebo-controlled double-blind clinical trial.	Vitamin D	14-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	59-70
27904547-4	2016	The goal of this study was to find the effect of vitamin D administration on serum levels of leptin and adiponectin in ESRD patients.	Vitamin D	49-58	adiponectin, C1Q and collagen domain containing	Homo sapiens	104-115
27904547-11	2016	This study showed that vitamin D administration is associated with an increase in adiponectin and a decrease in leptin level in ESRD patients.	Vitamin D	23-32	adiponectin, C1Q and collagen domain containing	Homo sapiens	82-93
25524404-2	2016	On the basis of adult studies showing that vitamin D improves insulin sensitivity and decreases inflammatory cytokines linked to microvascular complications, we hypothesized that treating vitamin D deficiency in adolescents with type 1 diabetes would improve glycemia and reduce inflammatory markers.	Vitamin D	43-52	insulin	Homo sapiens	62-69
25524404-2	2016	On the basis of adult studies showing that vitamin D improves insulin sensitivity and decreases inflammatory cytokines linked to microvascular complications, we hypothesized that treating vitamin D deficiency in adolescents with type 1 diabetes would improve glycemia and reduce inflammatory markers.	Vitamin D	188-197	insulin	Homo sapiens	62-69
25524404-6	2016	Interleukin-6 (IL-6) was significantly higher in the vitamin D deficient group compared with the sufficient group (medians: 0.36 vs. 0.18) (p = 0.026), whereas neither C-reactive protein (CRP) nor tumor necrosis factor-alpha (TNF-alpha) differed.	Vitamin D	53-62	interleukin 6	Homo sapiens	0-13
25524404-6	2016	Interleukin-6 (IL-6) was significantly higher in the vitamin D deficient group compared with the sufficient group (medians: 0.36 vs. 0.18) (p = 0.026), whereas neither C-reactive protein (CRP) nor tumor necrosis factor-alpha (TNF-alpha) differed.	Vitamin D	53-62	interleukin 6	Homo sapiens	15-19
26799569-10	2016	Vitamin D status was inversely associated with body fat (%), homeostasis model assessment of insulin resistance (HOMA-IR), and total cholesterol/high density lipoprotein (TC/HDL) ratio, while positively associated with lean body mass (LBM) and hand grip strength (HGS).	Vitamin D	0-9	insulin	Homo sapiens	93-100
27195054-9	2016	In conclusion, the inflammatory cytokine TNF increases the response of keratinocytes to calcitriol through upregulation of its receptor VDR, which in turn is subject to negative feedback by the hormone accelerating the return of the keratinocyte vitamin D system to its basal activity.	Vitamin D	246-255	tumor necrosis factor	Homo sapiens	41-44
27333933-6	2016	An association between vitamin D content in the organism and levels of anabolic hormones such as insulin and testosterone has been reported.	Vitamin D	23-32	insulin	Homo sapiens	97-104
26654942-1	2016	Epidemiologic studies implicate vitamin D status as a factor that influences growth of EGFR mutant lung cancers.	Vitamin D	32-41	epidermal growth factor receptor	Homo sapiens	87-91
26654942-6	2016	To study anti-proliferative activity and signaling, EGFR mutant lung cancer cells were treated with the circulating metabolite of vitamin D, 25-hydroxyvitamin D3 (25D3).	Vitamin D	130-139	epidermal growth factor receptor	Homo sapiens	52-56
26654942-13	2016	These results identify EGFR mutant lung cancer as a vitamin D-responsive disease and diet-derived 25D3 as a direct VDR agonist and therapeutic agent.	Vitamin D	52-61	epidermal growth factor receptor	Homo sapiens	23-27
27229347-5	2016	Fibroblast growth factor-23-parathyroid hormone (PTH)-vitamin D axis, immunosuppressive therapy and previous bone status have been associated with PTBD.	Vitamin D	54-63	parathyroid hormone	Homo sapiens	49-52
26944102-6	2016	Clinical trials support a marginal reduction in circulating lipids and some meta-analysis support an increase in insulin sensitivity following vitamin D.	Vitamin D	143-152	insulin	Homo sapiens	113-120
26987336-1	2016	Recent studies have shown that vitamin D has an impact on the production and secretion of IGF-I in the liver.	Vitamin D	31-40	insulin like growth factor 1	Homo sapiens	90-95
26987336-8	2016	The results of our study suggest that vitamin D deficiency could influence IGF-I concentrations in children and adolescents with growth hormone deficiency, and vitamin D deficiency should be normalized before the measurement of IGF-I concentrations to obtain the reliable and unbiased IGF-I values.	Vitamin D	38-47	insulin like growth factor 1	Homo sapiens	75-80
27477034-13	2016	Multiple regression analysis showed a reverse relationship between vitamin D levels with IgE serum levels; this remained after adjustment for potential confounders (e.g. age, sex, BMI, FEV1, and FVC).	Vitamin D	67-76	immunoglobulin heavy constant epsilon	Homo sapiens	89-92
27229347-6	2016	Although several studies reported reduced PTH levels in KTRs receiving nutritional vitamin D, its effects on bone mineral density (BMD) remain controversial.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	42-45
27229347-7	2016	Active vitamin D reduced PTH levels and increased BMD after transplantation, but paricalcitol treatment was not accompanied by benefits on osteopenia.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	25-28
27403416-4	2016	The active form of vitamin D, 1,25-dihydroxyvitamin D (calcitriol), is biosynthesised in the kidney through the hydroxylation of 25-hydroxycholecalciferol by the CYP27B1 enzyme.	Vitamin D	19-28	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	162-169
26800186-12	2016	Compared to patients with sufficient vitamin D, patients with deficient vitamin D more frequently exhibited diabetes, elevated C-reactive protein levels, and hospital-acquired infections upon ICU admission, and they more frequently developed acute kidney injury.	Vitamin D	72-81	C-reactive protein	Homo sapiens	127-145
26646255-12	2016	Female sex steroids and vitamin-D promoted tendon-derived cell proliferation via estrogen receptor alpha and VDR, not estrogen receptor beta.	Vitamin D	24-33	estrogen receptor 1	Homo sapiens	81-104
26369816-8	2016	Here, we review the relationship between vitamin D analogs and inflammation based on observations of immune cells, prostaglandin and NFkappaB pathways, as well as common inflammatory diseases.	Vitamin D	41-50	nuclear factor kappa B subunit 1	Homo sapiens	133-141
27792005-2	2016	CYP27B1 is referred to as a vitamin D metabolizing enzyme.	Vitamin D	28-37	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
27413370-13	2016	Better vitamin D status may be protective of glucose homeostasis since 25(OH)D was negatively associated with insulin resistance in Chinese patients with type 2 diabetes.	Vitamin D	7-16	insulin	Homo sapiens	110-117
26264757-1	2016	BACKGROUND: Consistent data on the relation between vitamin D, body fat and insulin resistance (IR) in children are lacking.	Vitamin D	52-61	insulin	Homo sapiens	76-83
26985230-0	2016	The effect of vitamin D supplementation on blood sugar and different indices of insulin resistance in patients with non-alcoholic fatty liver disease (NAFLD).	Vitamin D	14-23	insulin	Homo sapiens	80-87
26985230-1	2016	BACKGROUND: Vitamin D supplementation has been shown to decrease insulin resistance through which it might cause fatty liver.	Vitamin D	12-21	insulin	Homo sapiens	65-72
25758239-2	2016	It has been shown in vitro that the active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25-D3) can upregulate expression of the calcium-sensing receptor (CaSR).	Vitamin D	43-52	calcium sensing receptor	Homo sapiens	159-163
25758239-4	2016	However, during tumorigenesis colonic CaSR expression is downregulated and we hypothesized that the loss of CaSR could influence the anti-tumorigenic effects of Ca(2+) and vitamin D.	Vitamin D	172-181	calcium sensing receptor	Homo sapiens	108-112
25758239-10	2016	Taken together, our data provides molecular evidence to support the epidemiological observation that both, vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR.	Vitamin D	107-116	calcium sensing receptor	Homo sapiens	268-272
25777538-12	2016	In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased.	Vitamin D	39-48	receptor tyrosine kinase-like orphan receptor 2	Mus musculus	84-88
26058412-8	2016	However, vitamin D could reverse the inhibition of both VDR and LL-37 [1.5-fold increase (P = 0.001) and 2000-fold increase (P &lt; 0.001) respectively].	Vitamin D	9-18	cathelicidin antimicrobial peptide	Homo sapiens	64-69
26058412-9	2016	The effect of the incubation time following vitamin D supplementation was significant for LL-37 expression, with a peak expression found at 36 h (P &lt; 0.001).	Vitamin D	44-53	cathelicidin antimicrobial peptide	Homo sapiens	90-95
26058412-10	2016	CONCLUSIONS: When vitamin D levels were low, bacteria inhibited VDR and LL-37 responses in peritoneal macrophages as a mechanism to evade antibacterial defence.	Vitamin D	18-27	cathelicidin antimicrobial peptide	Homo sapiens	72-77
26058412-11	2016	Vitamin D supplementation could up-regulate peritoneal macrophage VDR and LL-37 expressions, which resulted in an enhanced immunological defence against SBP in patients with cirrhosis and ascites.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	74-79
27298518-7	2016	Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation (p = 0.006).	Vitamin D	9-18	toll like receptor 7	Homo sapiens	94-98
26602143-1	2016	Patients with significant proteinuria represent a unique population with respect to vitamin D status due to the urinary losses of vitamin D-binding protein (DBP) to which &gt;99 % of circulating 25-hydroxy vitamin D (25(OH)D) is bound.	Vitamin D	84-93	D-box binding PAR bZIP transcription factor	Homo sapiens	157-160
26255991-0	2016	Vitamin D in polycystic ovary syndrome: Relationship to obesity and insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	68-75
26567701-1	2016	The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting.	Vitamin D	194-203	fibroblast growth factor 21	Homo sapiens	55-60
26394645-9	2016	Among the so-called pleiotropic effects of vitamin D, those resulting from the inhibitory effect on the renin-angiotensin system are of particular interest for nephrologists.	Vitamin D	43-52	renin	Homo sapiens	104-109
26707812-2	2016	The injection of vitamin D induces cystathionine-beta-synthase (CBS) expression and H2S generation.	Vitamin D	17-26	cystathionine beta synthase	Rattus norvegicus	35-62
26707812-2	2016	The injection of vitamin D induces cystathionine-beta-synthase (CBS) expression and H2S generation.	Vitamin D	17-26	cystathionine beta synthase	Rattus norvegicus	64-67
26707812-3	2016	However, it remains unclear whether the supplementation of vitamin D prevents DPN through improvement of CBS/H2S expression.	Vitamin D	59-68	cystathionine beta synthase	Rattus norvegicus	105-108
26758099-0	2016	Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research.	Vitamin D	69-78	parathyroid hormone	Homo sapiens	0-19
26366751-4	2016	Vitamin D receptor activation using a vitamin D responsive element-mediated cytochrome P450 3A4 reporter gene assay was investigated in Caco-2 cells transfected with human vitamin D receptor.	Vitamin D	38-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	76-95
27579030-0	2016	Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis.	Vitamin D	51-60	peroxisome proliferator activated receptor gamma	Homo sapiens	41-46
26844688-2	2016	Our aim is to find out the effect of replacement of low dose oral vitamin-D (800 International unit) with calcium (500mg) as a once daily regimen along with antiretroviral (ARV) on serum vitamin-D and parathyroid hormone (PTH) level and bone mineral density (BMD) changes on patients with HIV infection who have vitamin- D deficiency.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	201-220
26844688-12	2016	In multivariate analysis that included all significant variables, vitamin-D and calcium replacement independently was associated with increase in vitamin-D level (OR 1.07, CI 1.02, 1.12, p=0.005), decrease in PTH level (OR 0.53, CI 0.35, 0.82, p=0.004), but not with change in corrected calcium, alkaline phosphatase, BMD of hip or spine.	Vitamin D	66-75	alkaline phosphatase, placental	Homo sapiens	296-316
27956902-1	2016	1alpha,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D (Vit D), increases intestinal absorption of calcium and phosphate, maintaining a correct balance of bone remodeling.	Vitamin D	19-28	vitrin	Homo sapiens	81-84
26827957-7	2016	Thus, it appears that vitamin D promotes cardiac differentiation through negative modulation of the canonical Wnt signaling pathway and upregulation of noncanonical Wnt11 expression.	Vitamin D	22-31	Wnt family member 11	Homo sapiens	110-113
26827957-7	2016	Thus, it appears that vitamin D promotes cardiac differentiation through negative modulation of the canonical Wnt signaling pathway and upregulation of noncanonical Wnt11 expression.	Vitamin D	22-31	Wnt family member 11	Homo sapiens	165-170
26827958-5	2016	Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors.	Vitamin D	22-31	androgen receptor	Homo sapiens	201-203
26827958-7	2016	Androgen inhibits vitamin D-mediated induction of CYP24A1, the calcitriol-degrading enzyme, while vitamin D promotes androgen inactivation by inducing phase I monooxygenases (e.g., CYP3A4) and phase II transferases (e.g., SULT2B1b, a DHEA-sulfotransferase).	Vitamin D	98-107	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	181-187
26719974-6	2015	Four of these candidate variants (one each in CXXC1 and RUNX2 and two in LRP5) had a &gt;70% derived allele frequency in East Asians, but were present at lower (20-60%) frequency in Europeans as well, suggesting that the adaptation might have been part of a common response to climatic and dietary changes as humans expanded out of Africa, with implications for their role in vitamin D-dependent bone mineralization and osteoporosis insurgence.	Vitamin D	376-385	RUNX family transcription factor 2	Homo sapiens	56-61
26719974-6	2015	Four of these candidate variants (one each in CXXC1 and RUNX2 and two in LRP5) had a &gt;70% derived allele frequency in East Asians, but were present at lower (20-60%) frequency in Europeans as well, suggesting that the adaptation might have been part of a common response to climatic and dietary changes as humans expanded out of Africa, with implications for their role in vitamin D-dependent bone mineralization and osteoporosis insurgence.	Vitamin D	376-385	LDL receptor related protein 5	Homo sapiens	73-77
26885262-6	2015	MEK/ERK and PTEN/PI3K/Akt/mTOR were both found critically involved in vitamin D-induced autophagy.	Vitamin D	70-79	mitogen-activated protein kinase 1	Mus musculus	4-7
26885262-6	2015	MEK/ERK and PTEN/PI3K/Akt/mTOR were both found critically involved in vitamin D-induced autophagy.	Vitamin D	70-79	phosphatase and tensin homolog	Mus musculus	12-16
26885262-6	2015	MEK/ERK and PTEN/PI3K/Akt/mTOR were both found critically involved in vitamin D-induced autophagy.	Vitamin D	70-79	thymoma viral proto-oncogene 1	Mus musculus	22-25
26282787-0	2015	MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential.	Vitamin D	13-22	septin 4	Homo sapiens	0-4
26282787-4	2015	The new class of less-calcemic vitamin D analog, 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 (MART-10), is much more potent than 1alpha,25(OH)2D3 to repress cancer growth and metastasis in a variety of cancers.	Vitamin D	31-40	septin 4	Homo sapiens	112-116
26641549-8	2015	RESULTS: When treated with inactive vitamin D metabolites, HCEC produced active 1,25D3, leading to enhanced expression of the antimicrobial peptide, LL-37, dependent on VDR.	Vitamin D	36-45	cathelicidin antimicrobial peptide	Homo sapiens	149-154
26713058-10	2015	In patients with NASH, however, low serum vitamin D is associated with hepatic fibrosis and insulin resistance, but not with bone health status.	Vitamin D	42-51	insulin	Homo sapiens	92-99
26620985-10	2015	CONCLUSION: Twelve-month vitamin D supplementation of 2000IU per day in a cohort of treatment naive Saudi patients with T2DM resulted in improvement of several cardiometabolic parameters including systolic blood pressure, insulin, and HOMA-IR.	Vitamin D	25-34	insulin	Homo sapiens	222-229
26319615-3	2015	OBJECTIVES: To evaluate the effects of vitamin D (25(OH)D3 and 1,25(OH)2D3) on the secretion of inflammatory cytokines (TNF-alpha and IL-6) in omental (OM) and SC human AT and to explore factors that could correlate with the individual response to vitamin D including age, smoking status, BMI, comorbidities, medication, HbA1c, apolipoprotein B, serum 25-hydroxyvitamin D and high sensitivity C-reactive protein.	Vitamin D	39-48	tumor necrosis factor	Homo sapiens	120-129
26337807-0	2015	Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials.	Vitamin D	48-57	parathyroid hormone	Homo sapiens	16-35
26337807-1	2015	This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	63-82
26337807-1	2015	This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	84-87
26337807-9	2015	Vitamin D supplementation significantly reduced PTH level with PMD of -8 0 pg/ml, with significant heterogeneity ((test for heterogeneity: P&lt;0 001) and the I 2 value was 97 3%).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	48-51
26337807-11	2015	Despite the present meta-analysis being hindered by some limitations, it provided some interesting evidence, suggesting that suppression of PTH level needs higher vitamin D intake (75 mug/d) than the current recommendations and longer durations (12 months), which should be taken into account for nutritional recommendations.	Vitamin D	163-172	parathyroid hormone	Homo sapiens	140-143
26561037-18	2015	One study reported vitamin D preparations significantly reduced PTH levels (-55.00 pmol/L, 95% CI -83.03 to -26.97).	Vitamin D	19-28	parathyroid hormone	Homo sapiens	64-67
26561037-28	2015	AUTHORS" CONCLUSIONS: Bone disease, assessed by changes in PTH levels, is improved by all vitamin D preparations.	Vitamin D	90-99	parathyroid hormone	Homo sapiens	59-62
26569292-0	2015	Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.	Vitamin D	28-37	C-reactive protein	Homo sapiens	42-60
26543018-0	2015	The effect of vitamin D supplementation on insulin and glucose metabolism in overweight and obese individuals: systematic review with meta-analysis.	Vitamin D	14-23	insulin	Homo sapiens	43-50
26734137-0	2015	Case report: vitamin D-dependent rickets type 1 caused by a novel CYP27B1 mutation.	Vitamin D	13-22	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	66-73
26734137-1	2015	Vitamin D-dependent rickets type 1 VDDR-1 is a recessive inherited disorder with impaired activation of vitamin D, caused by mutations in CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	138-145
26734137-1	2015	Vitamin D-dependent rickets type 1 VDDR-1 is a recessive inherited disorder with impaired activation of vitamin D, caused by mutations in CYP27B1.	Vitamin D	104-113	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	138-145
26447159-0	2015	Vitamin D status is inversely associated with anemia and serum erythropoietin during pregnancy.	Vitamin D	0-9	erythropoietin	Homo sapiens	63-77
26447159-8	2015	A mediation analysis was performed to examine direct and indirect relations between vitamin D status, hemoglobin, and erythropoietin in maternal serum.	Vitamin D	84-93	erythropoietin	Homo sapiens	118-132
26404398-1	2015	Bioactive vitamin D is a steroid hormone transported in blood via the vitamin D binding protein (DBP).	Vitamin D	10-19	D-box binding PAR bZIP transcription factor	Homo sapiens	97-100
26404398-8	2015	A significant positive correlation was observed between vitamin D status and DBP.	Vitamin D	56-65	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
26364161-2	2015	Beyond VDR, the biologic effects of vitamin D are mediated by the vitamin D-binding protein (DBP), a key protein in vitamin D metabolism.	Vitamin D	36-45	D-box binding PAR bZIP transcription factor	Homo sapiens	93-96
26364161-2	2015	Beyond VDR, the biologic effects of vitamin D are mediated by the vitamin D-binding protein (DBP), a key protein in vitamin D metabolism.	Vitamin D	66-75	D-box binding PAR bZIP transcription factor	Homo sapiens	93-96
26364161-3	2015	Furthermore, the gene encoding the DBP (GC, group-specific component) has an important role in the vitamin D pathway.	Vitamin D	99-108	D-box binding PAR bZIP transcription factor	Homo sapiens	35-38
26186566-10	2015	Parathyroid hormone levels decreased over the study period with patients achieving vitamin D sufficiency at day 7 having significantly lower parathyroid hormone levels (p&lt;0.01).	Vitamin D	83-92	parathyroid hormone	Homo sapiens	0-19
26186566-10	2015	Parathyroid hormone levels decreased over the study period with patients achieving vitamin D sufficiency at day 7 having significantly lower parathyroid hormone levels (p&lt;0.01).	Vitamin D	83-92	parathyroid hormone	Homo sapiens	141-160
26949498-10	2015	Vitamin D up-regulated the expression levels of Bcl-2 by (18.87 fold increase), and down-regulated expression of Bax (23%) and FasL (25%).	Vitamin D	0-9	BCL2 apoptosis regulator	Homo sapiens	48-53
26949498-10	2015	Vitamin D up-regulated the expression levels of Bcl-2 by (18.87 fold increase), and down-regulated expression of Bax (23%) and FasL (25%).	Vitamin D	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
27666692-4	2016	Meta-analyses have shown that aberrant PTH-vitamin D axis may affect bone metabolism in smokers.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	39-42
26732135-7	2016	CONCLUSION: In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher.	Vitamin D	92-101	insulin	Homo sapiens	103-110
26982175-1	2016	BACKGROUND AND AIMS: Vitamin D-dependent rickets type I (VDDR1) is an autosomal recessive disorder caused by mutations in the 25-hydroxyvitamin D 1-alpha-hydroxylase gene (CYP27B1).	Vitamin D	21-30	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	172-179
26355467-10	2016	The low vitamin D group had higher baseline IL-6 levels (median, 4.4 [interquartile range, 2.0-5.7] versus 1.1 [0.8-1.7] pg/mL, P = 0.004) and lower interleukin-12 levels (0.3 [0.1-0.4] versus 0.5 [0.5-0.6] pg/mL, P = 0.006) compared with the normal vitamin D group.	Vitamin D	8-17	interleukin 6	Homo sapiens	44-48
26355467-11	2016	At week 14, IL-8 levels were significantly lower in the low vitamin D group compared with the normal vitamin D group (11.2 [9.1-13.8] versus 20.5 [17.9-37.2] pg/mL, P = 0.005).	Vitamin D	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
27413370-0	2016	Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes.	Vitamin D	0-9	insulin	Homo sapiens	47-54
27413370-2	2016	Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus.	Vitamin D	0-9	insulin	Homo sapiens	37-44
27413370-3	2016	Little information is available about the association between vitamin D status and insulin resistance in the Chinese population.	Vitamin D	62-71	insulin	Homo sapiens	83-90
27692178-2	2016	CaSR is the most important master controller of the extracellular Ca2+ homeostatic system being expressed at high levels in the parathyroid gland, kidney, gut and bone, where it regulates parathyroid hormone (PTH) secretion, vitamin D synthesis, and Ca2+ absorption and resorption, respectively.	Vitamin D	225-234	calcium sensing receptor	Homo sapiens	0-4
27713770-7	2016	Generally, Vit D levels were associated indirectly with leukocytes/ neutrophils number or with ESR, CRP, and Fibrinogen levels.	Vitamin D	11-16	C-reactive protein	Homo sapiens	100-103
27713770-7	2016	Generally, Vit D levels were associated indirectly with leukocytes/ neutrophils number or with ESR, CRP, and Fibrinogen levels.	Vitamin D	11-16	fibrinogen beta chain	Homo sapiens	109-119
27713770-9	2016	Discussion:Altered levels of Vit D affect the balance between LL-37, IL-8 and SAA, suggesting an association with AAU, an extra-articular manifestation of AS.	Vitamin D	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
27313879-6	2016	The human formulation of activated vitamin D (calcitriol) had the most dramatic reduction in CLIP density at an MFI of 257.3 [baseline of 701.1 (P value = 0.01)].	Vitamin D	35-44	proopiomelanocortin	Homo sapiens	93-97
26387558-0	2016	Heparanase: another renal player controlled by vitamin D.	Vitamin D	47-56	heparanase	Homo sapiens	0-10
26387558-2	2016	Clinical and experimental therapies with vitamin D supplements or analogues have demonstrated nephroprotective effects, which vitamin D exerts partly by controlling the renin-angiotensin-aldosterone system, but also by modulating other signalling pathways.	Vitamin D	41-50	renin	Homo sapiens	169-174
26387558-2	2016	Clinical and experimental therapies with vitamin D supplements or analogues have demonstrated nephroprotective effects, which vitamin D exerts partly by controlling the renin-angiotensin-aldosterone system, but also by modulating other signalling pathways.	Vitamin D	126-135	renin	Homo sapiens	169-174
26387558-3	2016	In recent work published in the Journal of Pathology, Garsen and colleagues identified heparanase as a novel target of vitamin D and its antiproteinuric activity.	Vitamin D	119-128	heparanase	Homo sapiens	87-97
26387558-5	2016	The new evidence that vitamin D inhibits heparanase expression sets the stage for a better understanding of the vitamin"s kidney-protecting effects and its possible application to proteinuric and non-proteinuric chronic kidney diseases.	Vitamin D	22-31	heparanase	Homo sapiens	41-51
26058412-0	2016	Enhanced LL-37 expression following vitamin D supplementation in patients with cirrhosis and spontaneous bacterial peritonitis.	Vitamin D	36-45	cathelicidin antimicrobial peptide	Homo sapiens	9-14
26058412-2	2016	This study aimed to determine the role of the vitamin D-LL-37 pathway in the pathogenesis and treatment in patients with cirrhosis and SBP.	Vitamin D	46-55	cathelicidin antimicrobial peptide	Homo sapiens	56-61
27561026-0	2016	[Vitamin D deficiency associated with insulin resistance in medical residents].	Vitamin D	1-10	insulin	Homo sapiens	38-45
27561026-1	2016	BACKGROUND: Several studies have reported a correlation between vitamin D deficiency and insulin resistance; however, other clinical trials show that vitamin D supplementation do not normalize glucose and insulin levels.	Vitamin D	64-73	insulin	Homo sapiens	89-96
26612442-1	2016	The calcium-sensing receptor (CaSR) expressed in the parathyroid gland and the kidney tubule acts as the calciostat and orchestrates blood calcium homeostasis by modulating production and release of parathyroid hormone (PTH) and active vitamin D that influence Ca(2+) fluxes across the bone, kidney and intestine.	Vitamin D	236-245	calcium sensing receptor	Homo sapiens	4-28
26612442-1	2016	The calcium-sensing receptor (CaSR) expressed in the parathyroid gland and the kidney tubule acts as the calciostat and orchestrates blood calcium homeostasis by modulating production and release of parathyroid hormone (PTH) and active vitamin D that influence Ca(2+) fluxes across the bone, kidney and intestine.	Vitamin D	236-245	calcium sensing receptor	Homo sapiens	30-34
27396549-11	2016	A significant positive correlation between FS and PTH at 12 months was found, which persisted after adjusting for vitamin D levels.	Vitamin D	114-123	parathyroid hormone	Homo sapiens	50-53
27396549-12	2016	CONCLUSION: FS is positively correlated with secondary hyperparathyroidism using vitamin D-adjusted PTH levels as a biochemical marker.	Vitamin D	81-90	parathyroid hormone	Homo sapiens	100-103
26450935-2	2015	Both vitamin D and sodium intake interact with the renin-angiotensin-aldosterone system.	Vitamin D	5-14	renin	Homo sapiens	51-56
26450935-7	2015	In Cox regression analyses, we assessed associations of vitamin D with developing increased albuminuria or reduced eGFR and potential interaction with sodium intake.	Vitamin D	56-65	epidermal growth factor receptor	Homo sapiens	115-119
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	159-175
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	tumor necrosis factor	Homo sapiens	236-244
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	interleukin 1 beta	Homo sapiens	246-253
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	interleukin 6	Homo sapiens	255-258
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	260-263
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	transforming growth factor beta 1	Homo sapiens	275-283
26416604-1	2015	AIMS/HYPOTHESIS: Vitamin D and related genetic variants are associated with obesity and insulin resistance.	Vitamin D	17-26	insulin	Homo sapiens	88-95
26416604-2	2015	We aimed to examine whether vitamin D metabolism-related variants affect changes in body weight and insulin resistance in response to weight-loss diets varying in macronutrient content.	Vitamin D	28-37	insulin	Homo sapiens	100-107
26416604-6	2015	The T allele (vitamin-D-increasing allele) of DHCR7 rs12785878 was associated with greater decreases in insulin and HOMA-IR (p &lt; 0.002) in response to high-protein diets, while there was no significant genotype effect on changes in these traits in the low-protein diet group.	Vitamin D	14-23	insulin	Homo sapiens	104-111
26375925-8	2015	There are inverse correlations between vitamin D and metabolic control and insulin resistance.	Vitamin D	39-48	insulin	Homo sapiens	75-82
26540562-4	2015	The cutoff value for vitamin D deficiency was based on the changes in parathyroid hormone (PTH) level according to serum 25(OH)D value.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	70-89
26319615-7	2015	MAIN OUTCOME MEASURE: Change in TNF-alpha and IL-6 levels in collected media after vitamin D treatment (ELISA).	Vitamin D	83-92	tumor necrosis factor	Homo sapiens	32-41
26319615-7	2015	MAIN OUTCOME MEASURE: Change in TNF-alpha and IL-6 levels in collected media after vitamin D treatment (ELISA).	Vitamin D	83-92	interleukin 6	Homo sapiens	46-50
29391997-6	2015	There was a positive correlation between IFN-gamma and vitamin D levels (p&lt;0.05) in the study group, whereas IgE, IL-4, and IL-10 levels showed a negative correlation with vitamin D3 levels (p&lt;0.05).	Vitamin D	55-64	interferon gamma	Homo sapiens	41-50
26503864-5	2015	Based on the findings that liver is not only the major productive organ for 25OHD3but also the sole productive organ for DBP which serves to deliver 25OHD3to tissues and stores 25OHD3in the blood circulation, it is believed that liver plays important roles in vitamin D metabolism and vitamin D functions.	Vitamin D	260-269	D-box binding PAR bZIP transcription factor	Homo sapiens	121-124
26503864-5	2015	Based on the findings that liver is not only the major productive organ for 25OHD3but also the sole productive organ for DBP which serves to deliver 25OHD3to tissues and stores 25OHD3in the blood circulation, it is believed that liver plays important roles in vitamin D metabolism and vitamin D functions.	Vitamin D	285-294	D-box binding PAR bZIP transcription factor	Homo sapiens	121-124
26251265-2	2015	Active vitamin D (1alpha,25-dihydroxyvitamin D3; 1,25(OH)2 D3) up-regulates CD4(+) T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti-inflammatory adenosine.	Vitamin D	7-16	CD4 molecule	Homo sapiens	76-79
26485217-0	2015	Vitamin D Supplementation Decreases TGF-beta1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	36-45
26485217-2	2015	Vitamin D (VD) supplementation improves various clinical manifestations of PCOS and decreases TGF-beta1 levels in several diseases including myelofibrosis.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	94-103
26255277-0	2015	Multiple beta-defensin genes are upregulated by the vitamin D pathway in cattle.	Vitamin D	52-61	LOC100296173	Bos taurus	9-22
26170242-4	2015	1alpha,25(OH)2D is converted from 25(OH)D, the index of serum vitamin D status, by CYP27B1, which is originally found in kidneys but recently detected in non-renal tissues.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	83-90
26255277-7	2015	Furthermore, preliminary investigation of vitamin D"s contribution to beta-defensin expression in vivo revealed that intramammary 1,25D treatment of lactating cows increased BNBD7 expression in mammary macrophages.	Vitamin D	42-51	LOC100296173	Bos taurus	70-83
26255277-8	2015	In conclusion, our data demonstrate that multiple beta-defensin genes are upregulated by 1,25D in cattle, providing further indication that vitamin D contributes to bovine innate immunity.	Vitamin D	140-149	LOC100296173	Bos taurus	50-63
26178144-0	2015	Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1.	Vitamin D	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
26176830-1	2015	Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	33-36
26176830-1	2015	Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D.	Vitamin D	95-104	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	33-36
26632733-1	2015	Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS).	Vitamin D	48-57	RLS1	Homo sapiens	112-115
26332676-1	2015	Vitamin D-binding protein (DBP) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D.	Vitamin D	185-194	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
26332676-2	2015	Nearly all circulating vitamin D (~85-90%) circulates bound to DBP, with a smaller proportion bound to albumin, leaving &lt;5% circulating freely.	Vitamin D	23-32	D-box binding PAR bZIP transcription factor	Homo sapiens	63-66
26332676-3	2015	DBP may also play roles beyond vitamin D binding, with potential roles in the immune system and elsewhere.	Vitamin D	31-40	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
26332676-4	2015	Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity.	Vitamin D	164-173	D-box binding PAR bZIP transcription factor	Homo sapiens	26-29
26332676-4	2015	Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity.	Vitamin D	164-173	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115
26332676-4	2015	Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity.	Vitamin D	164-173	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115
26424141-3	2015	Activated vitamin D has been proven to decrease parathyroid hormone (PTH) levels in dialysis patients and is currently used for this indication.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	48-67
26488726-1	2015	Observational and intervention studies have revealed inconsistent findings with respect to the relationship between vitamin D and insulin resistance.	Vitamin D	116-125	insulin	Homo sapiens	130-137
26488726-3	2015	In the present study we examined whether temporal improvements in vitamin D status, measured as serum 25-hydroxyvitamin D [25(OH)D], reduce the risk of insulin resistance among individuals without T2D.	Vitamin D	66-75	insulin	Homo sapiens	152-159
26488726-11	2015	These observations suggest that improvements in vitamin D status reduce the risk for insulin resistance and herewith may contribute to the primary prevention of T2D and CVD.	Vitamin D	48-57	insulin	Homo sapiens	85-92
26770399-7	2015	Both the mean fluorescence intensity and the positive percentage of monocytes TLR4 in the vitamin D group were significantly lower compared to the placebo group, as well as the concentrations of secreted TNF-alpha, IL-6, and IL-1, while the concentration of IL-10 was higher.	Vitamin D	90-99	tumor necrosis factor	Homo sapiens	204-213
26543719-9	2015	Possible mechanisms for clinical improvement include effects of vitamin D on components of inflammatory cascades, including tumor necrosis factor-alpha and prostaglandin D2, which result in decrease in central nervous system homeostatic sleep pressure.	Vitamin D	64-73	tumor necrosis factor	Homo sapiens	124-151
25988614-6	2015	Furthermore, in the skin CYP11A1 acts on 7-dehydrocholesterol with production of 7-dehydropregnolone, which can be further metabolized to other Delta7steroids, which after exposure to UVB undergo photochemical transformation to vitamin D like compounds with a short side chain.	Vitamin D	228-237	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	25-32
25988614-7	2015	Vitamin D and lumisterol, produced in the skin after exposure to UVB, are also metabolized by CYP11A1 to several hydroxyderivatives.	Vitamin D	0-9	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	94-101
27022466-2	2015	In vitro studies have also shown that vitamin D may affect the expression of CYP3A4.	Vitamin D	38-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
26458880-4	2015	Multivariate analysis was performed to identify environmental and genetic determinants of vitamin D status: polymorphisms in genes encoding the vitamin D receptor, vitamin D 25-hydroxylase enzyme CYP2R1 and vitamin D binding protein [DBP] were investigated.	Vitamin D	90-99	D-box binding PAR bZIP transcription factor	Homo sapiens	234-237
26375724-16	2015	However, LL-37 expression is vitamin D dependent, and inadequate serum levels (&lt; 30 ng/mL) were present in 72% of those tested.	Vitamin D	29-38	cathelicidin antimicrobial peptide	Homo sapiens	9-14
26178144-2	2015	Vitamin D transcriptionally up-regulates the anti-inflammatory gene DUSP1, which partly controls production of the inflammatory chemokine IL-8.	Vitamin D	0-9	dual specificity phosphatase 1	Homo sapiens	68-73
26178144-2	2015	Vitamin D transcriptionally up-regulates the anti-inflammatory gene DUSP1, which partly controls production of the inflammatory chemokine IL-8.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
26178144-4	2015	We tested the ability of vitamin D metabolites to down-regulate IL-8 production in CF macrophages.	Vitamin D	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
26178144-8	2015	As potential anti-inflammatory mechanism of vitamin D metabolites, we assessed up-regulation of DUSP1.	Vitamin D	44-53	dual specificity phosphatase 1	Homo sapiens	96-101
26178144-10	2015	Vitamin D metabolites down-regulated stimulated IL-8 only in those hyperinflammatory MDM, and only when used at high doses (&gt;100 nM for 25OHD3 , or &gt;1 nM for 1,25(OH)2 D3 and paricalcitol).	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
26178144-11	2015	The magnitude of IL-8 down-regulation by vitamin D metabolites or paricalcitol was moderate (~30% vs. &gt;70% by low-dose dexamethasone).	Vitamin D	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26178144-12	2015	Transcriptional up-regulation of DUSP1 by vitamin D metabolites was seen in all tested MDM, regardless of IL-8 down-regulation.	Vitamin D	42-51	dual specificity phosphatase 1	Homo sapiens	33-38
26178144-13	2015	CONCLUSIONS AND IMPLICATIONS: Vitamin D metabolites and their analogues moderately down-regulate IL-8 in hyperinflammatory macrophages, including those from CF.	Vitamin D	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
26222607-9	2015	The random and fixed-effects meta-analysis showed that vitamin D significantly increased systolic blood pressure and LDL-C levels.	Vitamin D	55-64	component of oligomeric golgi complex 2	Homo sapiens	117-122
26448381-1	2015	Vitamin D is claimed to have an adjuvant effect on glycemic control by dual action on pancreatic beta-cells and insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	112-119
26448381-10	2015	This vitamin D rise was associated with highly significant improvement in concentrations of fasting blood sugar (FBS), fasting insulin, HbA1c%, and HOMA-beta-cell function in diabetic and non-diabetic controls.	Vitamin D	5-14	insulin	Homo sapiens	127-134
26196951-1	2015	CONTEXT: Vitamin D binding protein (DBP) is an important determinant of bioavailable vitamin D (BAVD) and may provide clues to racial variation in osteoporosis and atherosclerosis.	Vitamin D	85-94	D-box binding PAR bZIP transcription factor	Homo sapiens	36-39
26048596-0	2015	Parathyroid hormone response to two levels of vitamin D deficiency is associated with high risk of medical problems during hospitalization in patients with hip fracture.	Vitamin D	46-55	parathyroid hormone	Homo sapiens	0-19
26317560-5	2015	Insulin-resistant children showed higher bioavailable levels of 25-hydroxyvitamin D compared with noninsulin-resistant children (3.4 +- 1.4 ng/mL vs 2.0 +- 0.9 ng/mL; P = .013) and an inverse correlation between insulin resistance and vitamin D-binding protein was found (r:= -0.40; P = .024).	Vitamin D	74-83	insulin	Homo sapiens	0-7
26204161-0	2015	Serum Sclerostin Levels in Newborns Born to Mothers With Vitamin D Deficiency.	Vitamin D	57-66	sclerostin	Homo sapiens	6-16
26204161-2	2015	The aim of this study was to investigate the association between circulating sclerostin (an emerging biomarker and important regulator of bone formation) and neonatal parameters in mothers with vitamin D deficiency.	Vitamin D	194-203	sclerostin	Homo sapiens	77-87
26204161-10	2015	CONCLUSIONS: We found significantly lower sclerostin levels in newborns born by women with vitamin D deficiency compared with newborns of nondeficient mothers.	Vitamin D	91-100	sclerostin	Homo sapiens	42-52
26622198-11	2015	CONCLUSION: Regarding to the relationship between serum levels of 25(OH)D and blood sugar and insulin at the second trimester of pregnancy, it is recommended for pregnant women to take vitamin D supplementation.	Vitamin D	185-194	insulin	Homo sapiens	94-101
25495336-5	2015	RESULTS: Treatment with 30 ng/mL of vitamin D3, corresponding to an optimal plasma concentration of vitamin D, for 24 h had no effect on PDL cell number and morphology but increased PDL cell osteopontin and osteocalcin mRNA expression by about 70 and 40%, respectively, and, moreover, treatment with vitamin D3 for 48 h enhanced PDL cell alkaline phosphatase activity by about two times showing that vitamin D3 exerts pro-osteogenic effects in human PDL cells.	Vitamin D	36-45	bone gamma-carboxyglutamate protein	Homo sapiens	207-218
26007153-0	2015	Serum sclerostin is decreased following vitamin D treatment in young vitamin D-deficient female adults.	Vitamin D	40-49	sclerostin	Homo sapiens	6-16
26488785-10	2015	The level of vitamin D was significantly associated with osteocalcin, c-telopeptide, calcium, alkaline phosphatase, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and glucose (P&lt;.01).	Vitamin D	13-22	bone gamma-carboxyglutamate protein	Homo sapiens	57-68
26007153-0	2015	Serum sclerostin is decreased following vitamin D treatment in young vitamin D-deficient female adults.	Vitamin D	69-78	sclerostin	Homo sapiens	6-16
26430465-11	2015	In the young vitamin-D group, the change in fiber type IIa percentage was greater after 12 weeks training (p = 0.030) and Myostatin mRNA expression lower compared to the placebo group (p = 0.006).	Vitamin D	13-22	myostatin	Homo sapiens	122-131
26068064-7	2015	These results suggest that the suppression of generation of ROS and increased phosphorylation level of MLC might be one of the mechanisms underlying the protective effect of 1,25(OH)2D3 on ethanol-induced intestinal barrier injury and provide evidence for the application of vitamin D as therapeutic factors against ethanol-induced gut leakiness.	Vitamin D	275-284	modulator of VRAC current 1	Homo sapiens	103-106
26398210-3	2015	The association between values of vitamin D and parathyroid hormone (PTH), and COPD severity including lung function and quality of life, were analyzed.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	69-72
26210580-16	2015	This study has, for the first time, shown that vitamin D directly modulates TH expression and strongly suggests N-cadherin may be a plausible mediator of this process both in vitro and in vivo.	Vitamin D	47-56	tyrosine hydroxylase	Homo sapiens	76-78
26398210-4	2015	RESULTS: In COPD patients, lung function was inversely related to PTH values (P = 0.02 for FVC [% predicted]; P &lt; 0.001 for FEV1 [% predicted]); however, the association of lung function with vitamin D levels was not statistically significant in a multivariable analysis.	Vitamin D	195-204	parathyroid hormone	Homo sapiens	66-69
26112182-5	2015	In silico analysis of the human SOST gene revealed a single putative DR3-type vitamin D response element (VDRE) at position -6216 bp upstream of the transcription start site (TSS).	Vitamin D	78-87	sclerostin	Homo sapiens	32-36
25980743-6	2015	PTH values were higher and BMD at both femoral sites were lower in patients with vitamin D&lt;20 ng/ml.	Vitamin D	81-90	parathyroid hormone	Homo sapiens	0-3
26665399-12	2015	Stimulation with calcitriol and other vitamin D analogs led to decrease BCL-2/BAX mRNA ratio in each cell lines.	Vitamin D	38-47	BCL2 apoptosis regulator	Homo sapiens	72-77
26665399-12	2015	Stimulation with calcitriol and other vitamin D analogs led to decrease BCL-2/BAX mRNA ratio in each cell lines.	Vitamin D	38-47	BCL2 associated X, apoptosis regulator	Homo sapiens	78-81
26100522-3	2015	In the present study, we examined the impact of 1,25(OH)2D3, the active metabolite of the nutritional supplement vitamin D on the chemopreventive efficacy of the EGFR inhibitor, erlotinib, against HNSCC.	Vitamin D	113-122	epidermal growth factor receptor	Homo sapiens	162-166
25920689-2	2015	Racial differences in fracture risk may be related to differences in bioavailable vitamin D due to single nucleotide polymorphism (SNP) variations in the vitamin D binding protein (DBP).	Vitamin D	82-91	D-box binding PAR bZIP transcription factor	Homo sapiens	181-184
25920689-15	2015	Marginal effects were seen in Whites for the DBP genotype associated with lower bioavailable vitamin D, but result inconclusive.	Vitamin D	93-102	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
26359412-1	2015	AIM: Vitamin D deficiency is thought to impair insulin action and glucose metabolism; however, previous studies have not examined ethnic differences.	Vitamin D	5-14	insulin	Homo sapiens	47-54
26179930-7	2015	Vitamin D administered to patients with macroprolactinemia increased 25-hydroxyvitamin, reduced total prolactin and macroprolactin, as well tended to reduce PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	157-160
25631218-7	2015	Specifically, we review studies describing the inhibition of renin activity by calcium and vitamin D, and a potentially bidirectional and stimulatory relationship between aldosterone and parathyroid hormone.	Vitamin D	91-100	renin	Homo sapiens	61-66
26188623-0	2015	Vitamin D supplementation up-regulates IL-6 and IL-17A gene expression in multiple sclerosis patients.	Vitamin D	0-9	interleukin 6	Homo sapiens	39-43
26188623-3	2015	The aim of this study was to investigate the vitamin D effects on the expression level of IL-6 and IL-17A in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients.	Vitamin D	45-54	interleukin 6	Homo sapiens	90-94
26188623-5	2015	Significant up-regulation of IL-6 and IL-17A gene expression was shown under vitamin D treatment.	Vitamin D	77-86	interleukin 6	Homo sapiens	29-33
26079779-10	2015	CONCLUSION: Vitamin D deficiency is associated with more severe PHPT as reflected by PTH levels, but effects on BMD are limited to the cortical 1/3 radius and are quite modest.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	85-88
26529809-0	2015	The Intriguing Correlation between Undercarboxylated Osteocalcin and Vitamin D.	Vitamin D	69-78	bone gamma-carboxyglutamate protein	Homo sapiens	53-64
26030788-4	2015	Free vitamin D was calculated using molar ratios of 25(OH)D and DBP.	Vitamin D	5-14	D-box binding PAR bZIP transcription factor	Homo sapiens	64-67
26180247-1	2015	BACKGROUND: Low vitamin D status has been associated with an increased risk of developing type 2 diabetes and insulin resistance (IR), although this has been recently questioned.	Vitamin D	16-25	insulin	Homo sapiens	110-117
26106052-0	2015	High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C-reactive protein.	Vitamin D	15-24	C-reactive protein	Homo sapiens	84-102
25714787-4	2015	In recent years, vitamin D deficiency has been implicated in the aetiology of type 2 diabetes, PCOS and CVD, and has been shown to be associated with their risk factors including obesity, insulin resistance, hypertension, as well as chronic low-grade inflammation.	Vitamin D	17-26	insulin	Homo sapiens	188-195
26327926-8	2015	We also demonstrate that AIrA is genetically determined: single nucleotide polymorphisms located in genes encoding key factors for the metabolism of estrogens and vitamin D (CYP17A1, VDR, and CYP27B1) are associated with self-reported arthralgia during AI therapy.	Vitamin D	163-172	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	192-199
26106052-2	2015	This study aimed to examine the hypothesis that vitamin D is inversely associated with C-reactive protein (CRP) in patients with schizophrenia, and high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.	Vitamin D	163-172	C-reactive protein	Homo sapiens	234-237
26106052-8	2015	The proportions of patients significantly increased with increasing quartiles of CRP, while significantly decreased with increasing quartiles of 25(OH)D. Among individuals with high CRP, participants with high 25(OH)D have significantly lower proportion (adjusted OR =0.217, 95% CI 0.063, 0.751) of schizophrenia compared to those with low 25(OH)D. The evidence suggested that high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.	Vitamin D	392-401	C-reactive protein	Homo sapiens	182-185
26106052-8	2015	The proportions of patients significantly increased with increasing quartiles of CRP, while significantly decreased with increasing quartiles of 25(OH)D. Among individuals with high CRP, participants with high 25(OH)D have significantly lower proportion (adjusted OR =0.217, 95% CI 0.063, 0.751) of schizophrenia compared to those with low 25(OH)D. The evidence suggested that high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.	Vitamin D	392-401	C-reactive protein	Homo sapiens	182-185
26165427-7	2015	It has been demonstrated that natural compounds derived from plants, vegetables, fungi and micronutrients (such as curcumin, sulforaphane, resveratrol and vitamin D among others) can activate Nrf2 and, thus, promote antioxidant pathways to mitigate oxidative stress and hyperglycemic damage.	Vitamin D	155-164	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
26294193-2	2015	Vitamin D-mediated induction of the host defence peptide LL-37 is known to enhance control of pathogens such as Mycobacterium tuberculosis.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	57-62
26283663-13	2015	The association between improved CD4 recovery and vitamin D repletion suggests a potential benefit of vitamin D supplementation on immunologic recovery during HIV treatment.	Vitamin D	50-59	CD4 molecule	Homo sapiens	33-36
26283663-13	2015	The association between improved CD4 recovery and vitamin D repletion suggests a potential benefit of vitamin D supplementation on immunologic recovery during HIV treatment.	Vitamin D	102-111	CD4 molecule	Homo sapiens	33-36
25612733-7	2015	This was mediated through suppression of SOCS3 and induction of vitamin D receptor binding with the vitamin D-response elements in the promoter of the gene encoding interferon gamma.	Vitamin D	64-73	interferon gamma	Mus musculus	165-181
26246241-4	2015	Observational and limited intervention studies suggest that vitamin D might improve insulin sensitivity and secretion, mainly via its anti-inflammatory properties, thereby decreasing the risk of development and progression of type 2 diabetes.	Vitamin D	60-69	insulin	Homo sapiens	84-91
26246241-5	2015	The primary aim of this trial is to investigate whether improved plasma concentrations of 25-hydroxyvitamin D (25(OH)D), obtained through vitamin D supplementation, will increase insulin sensitivity and insulin secretion.	Vitamin D	100-109	insulin	Homo sapiens	179-186
26246241-12	2015	DISCUSSION: The trial will provide much needed clinical evidence on the impact of vitamin D supplementation on insulin resistance and secretion and its underlying mechanisms, which are relevant for the prevention and management of type 2 diabetes.	Vitamin D	82-91	insulin	Homo sapiens	111-118
26331319-10	2015	Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p &lt; 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p &lt; 0.001).	Vitamin D	0-9	fibrinogen beta chain	Homo sapiens	57-67
25300649-10	2015	CONCLUSIONS: In conclusion, calcium plus vitamin D supplementation for eight weeks among vitamin D deficient women with PCOS had beneficial effects on serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels, but it did not affect FPG and other lipid profiles.	Vitamin D	41-50	insulin	Homo sapiens	157-164
25740667-10	2015	Vitamin D levels were negatively correlated with TNF-alpha and positively correlated with IL-4.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	49-58
25740667-10	2015	Vitamin D levels were negatively correlated with TNF-alpha and positively correlated with IL-4.	Vitamin D	0-9	interleukin 4	Homo sapiens	90-94
25740667-11	2015	CONCLUSIONS: Low vitamin D levels promotes Th1 activity increasing TNF-alpha levels and inhibits Th2 activity decreasing IL-4 levels in ovarian cancer.	Vitamin D	17-26	tumor necrosis factor	Homo sapiens	67-76
25740667-11	2015	CONCLUSIONS: Low vitamin D levels promotes Th1 activity increasing TNF-alpha levels and inhibits Th2 activity decreasing IL-4 levels in ovarian cancer.	Vitamin D	17-26	interleukin 4	Homo sapiens	121-125
26300676-2	2015	Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status.	Vitamin D	72-81	parathyroid hormone	Homo sapiens	6-25
25736056-8	2015	Four of these 11 genes (CYP24A1, CLMN, EFTUD1, and SERPINB1) were also identified as 1,25D responsive in human breast tumor explants, suggesting that this gene signature may prove useful as a biomarker of vitamin D exposure in breast tissue.	Vitamin D	205-214	calmin	Homo sapiens	33-37
26664421-4	2015	The goal of this study was to find the effect of Vitamin D administration in addition to the appropriate dose of EPO in ESRD patients with Vitamin D deficiency.	Vitamin D	139-148	erythropoietin	Homo sapiens	113-116
26664421-11	2015	There was a significant statistical relationship between Vitamin D administration and the required dose of EPO in both groups (P = 0.013).	Vitamin D	57-66	erythropoietin	Homo sapiens	107-110
26664421-13	2015	CONCLUSION: Based on the main finding of this study, the relationship between Vitamin D administration and required dose of EPO seems that the predicted dose of Vitamin D prescribing strategy in Kidney Disease Outcomes Quality Initiative guidelines is not adequate to achieve normal serum Vitamin D in ESRD patients.	Vitamin D	78-87	erythropoietin	Homo sapiens	124-127
26664421-13	2015	CONCLUSION: Based on the main finding of this study, the relationship between Vitamin D administration and required dose of EPO seems that the predicted dose of Vitamin D prescribing strategy in Kidney Disease Outcomes Quality Initiative guidelines is not adequate to achieve normal serum Vitamin D in ESRD patients.	Vitamin D	161-170	erythropoietin	Homo sapiens	124-127
26664421-13	2015	CONCLUSION: Based on the main finding of this study, the relationship between Vitamin D administration and required dose of EPO seems that the predicted dose of Vitamin D prescribing strategy in Kidney Disease Outcomes Quality Initiative guidelines is not adequate to achieve normal serum Vitamin D in ESRD patients.	Vitamin D	161-170	erythropoietin	Homo sapiens	124-127
26101151-0	2015	Vitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults.	Vitamin D	0-9	insulin	Homo sapiens	33-40
26101151-1	2015	This study aimed to evaluate the relationship between vitamin D (vitD) intake and serum concentrations and insulin secretion (assessed by C-peptide serum concentration)/insulin resistance (determined by estimated glucose disposal rate [eGDR]) in patients with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM).	Vitamin D	54-63	insulin	Homo sapiens	107-114
26148304-0	2015	Vitamin D, inflammation, and relations to insulin resistance in premenopausal women with morbid obesity.	Vitamin D	0-9	insulin	Homo sapiens	42-49
25517289-0	2015	Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males.	Vitamin D	5-14	insulin	Homo sapiens	113-120
25517289-8	2015	After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P&lt;0 05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men.	Vitamin D	6-15	insulin	Homo sapiens	117-124
25517289-10	2015	However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance.	Vitamin D	14-23	insulin	Homo sapiens	167-174
25517289-10	2015	However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance.	Vitamin D	80-89	insulin	Homo sapiens	167-174
26240702-0	2015	Is there a relationship between vitamin D with insulin resistance and diabetes mellitus?	Vitamin D	32-41	insulin	Homo sapiens	47-54
26240702-5	2015	In humans, it has been shown by majority of observational studies, that vitamin D is positively correlated with insulin sensitivity and its role is mediated both by direct mechanism through the availability of vitamin D receptors in several tissues and indirectly through the changes in calcium levels.	Vitamin D	72-81	insulin	Homo sapiens	112-119
26241902-8	2015	CD34+ cell number appeared to be associated with vitamin D levels, and negatively correlated to fibrinogen and early atherosclerosis markers (PWV and cIMT); vitamin D levels appear also to be inversely associated to fibrinogen.	Vitamin D	49-58	CD34 molecule	Homo sapiens	0-4
26241902-8	2015	CD34+ cell number appeared to be associated with vitamin D levels, and negatively correlated to fibrinogen and early atherosclerosis markers (PWV and cIMT); vitamin D levels appear also to be inversely associated to fibrinogen.	Vitamin D	157-166	fibrinogen beta chain	Homo sapiens	216-226
26241902-9	2015	CONCLUSIONS: RA patients with moderate disease activity presented with low vitamin D levels, low CD34+ cell count, increased PWV and cIMT; we found that vitamin D deficiency is associated to CD34+ cell reduction in peripheral blood, and with fibrinogen levels.	Vitamin D	153-162	CD34 molecule	Homo sapiens	97-101
26241902-9	2015	CONCLUSIONS: RA patients with moderate disease activity presented with low vitamin D levels, low CD34+ cell count, increased PWV and cIMT; we found that vitamin D deficiency is associated to CD34+ cell reduction in peripheral blood, and with fibrinogen levels.	Vitamin D	153-162	CD34 molecule	Homo sapiens	191-195
26241902-9	2015	CONCLUSIONS: RA patients with moderate disease activity presented with low vitamin D levels, low CD34+ cell count, increased PWV and cIMT; we found that vitamin D deficiency is associated to CD34+ cell reduction in peripheral blood, and with fibrinogen levels.	Vitamin D	153-162	fibrinogen beta chain	Homo sapiens	242-252
26156733-0	2015	Insulin secretion and sensitivity in healthy adults with low vitamin D are not affected by high-dose ergocalciferol administration: a randomized controlled trial.	Vitamin D	61-70	insulin	Homo sapiens	0-7
25053676-1	2015	Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia).	Vitamin D	0-9	insulin	Homo sapiens	137-144
25053676-5	2015	Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13).	Vitamin D	41-50	adiponectin, C1Q and collagen domain containing	Homo sapiens	97-108
25053676-6	2015	In conclusion, a positive trend was established between vitamin D and the protective adipocytokine adiponectin.	Vitamin D	56-65	adiponectin, C1Q and collagen domain containing	Homo sapiens	99-110
25840919-0	2015	Vitamin D Deficiency Adds an Element of Risk to Insulin Resistance in Colorectal Neoplasms.	Vitamin D	0-9	insulin	Homo sapiens	48-55
26142253-2	2015	Furthermore, obese individuals are at a greater risk for vitamin D deficiency which may increase the potential risk for chronic inflammation, insulin resistance, and metabolic syndrome.	Vitamin D	57-66	insulin	Homo sapiens	142-149
26106052-2	2015	This study aimed to examine the hypothesis that vitamin D is inversely associated with C-reactive protein (CRP) in patients with schizophrenia, and high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.	Vitamin D	48-57	C-reactive protein	Homo sapiens	87-105
26106052-2	2015	This study aimed to examine the hypothesis that vitamin D is inversely associated with C-reactive protein (CRP) in patients with schizophrenia, and high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.	Vitamin D	48-57	C-reactive protein	Homo sapiens	107-110
26207385-9	2015	Vitamin D inhibited TNFalpha-induced IL8 protein secretion levels to a comparable degree in fatal asthma- and non-asthma-derived ASM even though IL8 had significantly higher baseline levels in fatal asthma-derived ASM.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
25576857-5	2015	There was an interaction between vitamin D intake and weight on serum OC, insulin, glucose and markers of insulin sensitivity (p &lt; 0.05).	Vitamin D	33-42	insulin	Homo sapiens	106-113
25576857-7	2015	Overall, vitamin D supplementation and CR influence serum osteocalcin levels and modestly favor improvements in insulin sensitivity.	Vitamin D	9-18	bone gamma-carboxyglutamate protein	Homo sapiens	58-69
25576857-7	2015	Overall, vitamin D supplementation and CR influence serum osteocalcin levels and modestly favor improvements in insulin sensitivity.	Vitamin D	9-18	insulin	Homo sapiens	112-119
25934099-10	2015	Here we review how mTOR inhibition extends lifespan, how KLOTHO functions as an aging suppressor, how sirtuins mediate longevity, how vitamin D loss may contribute to age-related disease, and how they relate to mitochondrial function.	Vitamin D	134-143	mechanistic target of rapamycin kinase	Homo sapiens	19-23
25777546-1	2015	OBJECTIVE: Vitamin D modulates the immune response and blocks induction of an interferon (IFN) signature by systemic lupus erythematosus (SLE) sera.	Vitamin D	11-20	interferon alpha 1	Homo sapiens	78-88
25777546-1	2015	OBJECTIVE: Vitamin D modulates the immune response and blocks induction of an interferon (IFN) signature by systemic lupus erythematosus (SLE) sera.	Vitamin D	11-20	interferon alpha 1	Homo sapiens	90-93
25777546-2	2015	This study was undertaken to investigate the effects of vitamin D supplementation on the IFN signature in patients with SLE.	Vitamin D	56-65	interferon alpha 1	Homo sapiens	89-92
25941991-2	2015	Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) might account for similar bioavailable vitamin D in blacks despite lower mean 25(OH)D. We hypothesized that the associations of low 25(OH)D with CHD risk would be stronger among whites and among persons with genotypes associated with higher DBP levels.	Vitamin D	39-48	D-box binding PAR bZIP transcription factor	Homo sapiens	66-69
25941991-2	2015	Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) might account for similar bioavailable vitamin D in blacks despite lower mean 25(OH)D. We hypothesized that the associations of low 25(OH)D with CHD risk would be stronger among whites and among persons with genotypes associated with higher DBP levels.	Vitamin D	39-48	D-box binding PAR bZIP transcription factor	Homo sapiens	351-354
25908506-7	2015	In stratified analyses, participants randomized to vitamin D3 who lost 5% to 10% of baseline weight, versus participants who gained weight/had no weight-loss, had significantly greater decreases in levels of IL6 compared with those randomized to placebo: absolute change -0.75 pg/mL (-17.2%), placebo versus -1.77 pg/mL (-37.3%), vitamin D, P = 0.004.	Vitamin D	51-60	interleukin 6	Homo sapiens	208-211
25917139-8	2015	With diminishing exposure to ultraviolet B and consuming ~800 IU or 1800 IU (2011 and 2012, respectively) of supplemental vitamin D, the calves" midwinter (period 4) 25OHD concentrations fell to 15.2 +- 1.6 and 16.7 +- 1.5 ng/mL for 2011 and 2012, respectively, after 4 to 5 mo on a finishing diet (P &lt; 0.0001).	Vitamin D	122-131	25OHD	Bos taurus	166-171
25912414-6	2015	Factors protective against low vitamin D status were CD4 count below 200 cells per mm(3) (aOR 0.45, 95% CI 0.26-0.77) and protease inhibitors (aOR 0.62, 95% CI 0.40-0.95).	Vitamin D	31-40	CD4 molecule	Homo sapiens	53-56
26339419-0	2015	Association between promoter region genetic variants of PTH SNPs and serum 25(OH)-vitamin D level.	Vitamin D	82-91	parathyroid hormone	Homo sapiens	56-59
26339419-1	2015	Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	0-19
26339419-1	2015	Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	21-24
26339419-8	2015	In conclusion, our study indicated significant association between specific PTH gene promoter region variants and altered levels of 25(OH)D and vitamin D deficiency among specific nationals.	Vitamin D	144-153	parathyroid hormone	Homo sapiens	76-79
25873553-3	2015	This pilot study explores if vitamin D supplementation could reduce serum concentrations of inflammatory cytokines (interleukin [IL] 6, IL-10, tumor necrosis factor alpha), adiponectin, lipids, hemoglobin A1C, and high-sensitivity C-reactive protein (hs-CRP).	Vitamin D	29-38	tumor necrosis factor	Homo sapiens	143-170
25873553-3	2015	This pilot study explores if vitamin D supplementation could reduce serum concentrations of inflammatory cytokines (interleukin [IL] 6, IL-10, tumor necrosis factor alpha), adiponectin, lipids, hemoglobin A1C, and high-sensitivity C-reactive protein (hs-CRP).	Vitamin D	29-38	adiponectin, C1Q and collagen domain containing	Homo sapiens	173-184
26062551-0	2015	Vitamin D Promotes Odontogenic Differentiation of Human Dental Pulp Cells via ERK Activation.	Vitamin D	0-9	mitogen-activated protein kinase 1	Homo sapiens	78-81
26076051-0	2015	Induction of calcium sensing receptor in human colon cancer cells by calcium, vitamin D and aquamin: Promotion of a more differentiated, less malignant and indolent phenotype.	Vitamin D	78-87	calcium sensing receptor	Homo sapiens	13-37
26076051-4	2015	Here, we compare the effectiveness of Ca(2+), vitamin D, and Aquamin (a marine algae product containing Ca(2+), magnesium and detectable levels of 72 additional minerals) on the induction of CaSR in the CBS and HCT116 human colon carcinoma cell lines and the corresponding CaSR null cells isolated from these lines.	Vitamin D	46-55	calcium sensing receptor	Homo sapiens	191-195
26132292-0	2015	Novel CYP27B1 Gene Mutations in Patients with Vitamin D-Dependent Rickets Type 1A.	Vitamin D	46-55	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	6-13
26310644-14	2015	Steroid treatment, small intestine involved disease and high C reactive protein (more than 8 mg/L) are risk factors of vitamin D deficiency in CD children.	Vitamin D	119-128	C-reactive protein	Homo sapiens	61-79
26131437-1	2015	BACKGROUND: Vitamin D deficiency (VDD) is inversely associated with insulin resistance.	Vitamin D	12-21	insulin	Homo sapiens	68-75
26107738-4	2015	Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23.	Vitamin D	21-30	tumor necrosis factor	Homo sapiens	129-138
26107738-4	2015	Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23.	Vitamin D	21-30	interleukin 6	Homo sapiens	140-144
26107738-4	2015	Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23.	Vitamin D	21-30	interleukin 1 beta	Homo sapiens	146-154
26107738-6	2015	Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23.	Vitamin D	98-107	tumor necrosis factor	Homo sapiens	137-146
26107738-6	2015	Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23.	Vitamin D	98-107	interleukin 6	Homo sapiens	147-151
26207385-8	2015	Follow-up qPCR and individual analyte ELISA experiments were conducted for four cytokines (i.e. CCL2, CCL13, CXCL12, IL8) to measure TNFalpha-induced changes by asthma status and vitamin D treatment.	Vitamin D	179-188	tumor necrosis factor	Homo sapiens	133-141
26207385-9	2015	Vitamin D inhibited TNFalpha-induced IL8 protein secretion levels to a comparable degree in fatal asthma- and non-asthma-derived ASM even though IL8 had significantly higher baseline levels in fatal asthma-derived ASM.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	20-28
26193879-2	2015	Studies investigating the influence of genetic variants in vitamin D binding protein (DBP) and vitamin D 25-hydroxylase (CYP2R1) on vitamin D status and response to antituberculous therapy are lacking.	Vitamin D	59-68	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89
26300934-8	2015	In an unadjusted logistic model, PTH was the only variable in vitamin D endocrine system which was significantly associated with NASH (odds ratio (OR): 1.04, 95%CI: 1.01 - 1.07).	Vitamin D	62-71	parathyroid hormone	Homo sapiens	33-36
25576857-0	2015	Vitamin D supplementation during short-term caloric restriction in healthy overweight/obese older women: Effect on glycemic indices and serum osteocalcin levels.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	142-153
25576857-5	2015	There was an interaction between vitamin D intake and weight on serum OC, insulin, glucose and markers of insulin sensitivity (p &lt; 0.05).	Vitamin D	33-42	bone gamma-carboxyglutamate protein	Homo sapiens	70-72
25576857-5	2015	There was an interaction between vitamin D intake and weight on serum OC, insulin, glucose and markers of insulin sensitivity (p &lt; 0.05).	Vitamin D	33-42	insulin	Homo sapiens	74-81
26147588-3	2015	The aim of our study was to investigate whether vitamin D has an inhibitory effect on systemic inflammation by assessing the association between serum levels of vitamin D and C-reactive protein.	Vitamin D	48-57	C-reactive protein	Homo sapiens	175-193
26147588-3	2015	The aim of our study was to investigate whether vitamin D has an inhibitory effect on systemic inflammation by assessing the association between serum levels of vitamin D and C-reactive protein.	Vitamin D	161-170	C-reactive protein	Homo sapiens	175-193
26147588-7	2015	In conclusion, higher levels of Vitamin D are associated with lower levels of C-reactive protein.	Vitamin D	32-41	C-reactive protein	Homo sapiens	78-96
25992773-4	2015	Administration of 1alpha, 25-dihydroxy-3-epi-vitamin D3 (3-Epi, an endogenous low calcemic vitamin D metabolite) reduced Pit-1 expression, and synergized with cisplatin, thus, decreasing cell proliferation and apoptosis in vitro, and reducing tumor growth in vivo.	Vitamin D	45-54	POU class 1 homeobox 1	Homo sapiens	121-126
26078787-11	2015	Vitamin D levels were negatively related to all-cause mortality in men independently of age, PTH, HbA1c, waist circumference, 24-h systolic ambulatory-blood pressure (ABP) and serum-apoB (p = 0.049).	Vitamin D	0-9	apolipoprotein B	Homo sapiens	182-186
25992773-0	2015	Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment.	Vitamin D	73-82	POU class 1 homeobox 1	Homo sapiens	0-5
26061181-9	2015	CONCLUSIONS: Our results demonstrate that active vitamin D can prevent TGFbeta1-mediated biochemical and functional pro-fibrotic changes in human primary cardiac fibroblasts.	Vitamin D	49-58	transforming growth factor beta 1	Homo sapiens	71-79
26057782-1	2015	Gestational Diabetes Mellitus (GDM) and vitamin D deficiency are related to insulin resistance and impaired beta cell function, with heightened risk for future development of diabetes.	Vitamin D	40-49	insulin	Homo sapiens	76-83
26151689-0	2015	Association between serum vitamin D and parathyroid hormone levels in Turkish patients with colonic polyps.	Vitamin D	26-35	parathyroid hormone	Homo sapiens	40-59
25904755-1	2015	BACKGROUND AND OBJECTIVES: Direct comparison of cinacalcet and vitamin D analogs as monotherapies to lower parathyroid hormone (PTH) levels has not been undertaken.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	107-126
25904755-10	2015	CONCLUSIONS: Participants had similar modest reductions in PTH with either cinacalcet or vitamin D analog monotherapy over 52 weeks of treatment, but effects varied by region.	Vitamin D	89-98	parathyroid hormone	Homo sapiens	59-62
26124799-7	2015	CONCLUSION: Vitamin D deficiency, gestational diabetes and insulin resistance are interrelated.	Vitamin D	12-21	insulin	Homo sapiens	59-66
26154099-4	2015	The case of an 82-years old woman with PTH-independent hypercalcemia, lymphocytosis, normal serum 1,25 (OH)vitamin D levels, and low serum PTHrp levels, is described.	Vitamin D	107-116	parathyroid hormone	Homo sapiens	39-42
26009175-4	2015	This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways.	Vitamin D	5-14	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
25753408-9	2015	Importantly, Foxp2 immunoreactive cells in the developing cortex were reduced in vitamin D-deficient female foetuses.	Vitamin D	81-90	forkhead box P2	Mus musculus	13-18
26009175-4	2015	This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways.	Vitamin D	5-14	NFE2 like bZIP transcription factor 2	Homo sapiens	117-160
26009175-4	2015	This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways.	Vitamin D	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	117-160
25716637-5	2015	After 12 months, the vitamin D-supplemented group had a change in serum 25OHD +35 versus +6 ng/mL for placebo, P&lt;.001; OGIS +7.8 versus -16.0 mL x min(-1) x m(-2) for placebo, P = .026; and A1C -0.01 versus +0.01% for placebo, P = .66.	Vitamin D	21-30	CD59 molecule (CD59 blood group)	Homo sapiens	150-156
24953770-1	2015	BACKGROUND AND AIMS: Low vitamin D status has been linked to obesity, insulin resistance, and metabolic syndrome.	Vitamin D	25-34	insulin	Homo sapiens	70-77
24953770-10	2015	CONCLUSION: Among non-diabetic young adults, the potential inverse relationship between vitamin D status and metabolic syndrome may be attributable to the conjunctive effects of individual obesity and insulin resistance.	Vitamin D	88-97	insulin	Homo sapiens	201-208
25826095-2	2015	Vitamin D (vit.	Vitamin D	0-9	vitrin	Homo sapiens	11-14
25921345-0	2015	Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study.	Vitamin D	10-19	insulin	Homo sapiens	39-46
25921345-1	2015	To assess the effect of vitamin D supplementation on parameters of insulin sensitivity/resistance (IS/IR) and insulin secretion in subjects with polycystic ovarian syndrome (PCOS).	Vitamin D	24-33	insulin	Homo sapiens	67-74
25921345-2	2015	A prospective double-blind randomized control trial was conducted to assess the effect of vitamin D on insulin kinetics in women with PCOS.	Vitamin D	90-99	insulin	Homo sapiens	103-110
25274036-1	2015	The objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012.	Vitamin D	75-84	interferon gamma	Homo sapiens	200-216
25763635-3	2015	Of interest, vitamin D response elements, which allow responsiveness to 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], are present in the promoters of the CaSR gene.	Vitamin D	13-22	calcium sensing receptor	Homo sapiens	148-152
26296372-2	2015	It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis.	Vitamin D	106-115	parathyroid hormone	Homo sapiens	69-88
25774554-2	2015	A recent study showed that vitamin D deficiency exacerbated inflammation in nonalcoholic fatty liver disease through activating toll-like receptor 4 in a high-fat diet (HFD) rat model.	Vitamin D	27-36	toll-like receptor 4	Rattus norvegicus	128-148
25781493-8	2015	CONCLUSION: Vitamin D and glucose tolerance status are both independently associated with measures of insulin sensitivity, insulin secretion, and beta-cell function.	Vitamin D	12-21	insulin	Homo sapiens	102-109
26327893-3	2015	Conversely, the presence of comorbidities progressive with age such as abdominal obesity, insulin resistance, type 2 diabetes and hypertension places the patients at an increased risk of vitamin D deficiency.	Vitamin D	187-196	insulin	Homo sapiens	90-97
26042515-0	2015	The relationship between vitamin D status, physical activity and insulin resistance in overweight and obese subjects.	Vitamin D	25-34	insulin	Homo sapiens	65-72
26035242-8	2015	Most experts agree that vitamin D supplementation is a necessity, particularly in women suffering from obesity, insulin resistance or small ovarian reserve, as well as in men with oligo- and asthenozoospermia if serum concentration should fall below 50 nmol/L (normal range up to 125 nmol/L).	Vitamin D	24-33	insulin	Homo sapiens	112-119
26042515-3	2015	We aimed to determine the association between PA, vitamin D status and insulin resistance in overweight and obese subjects.	Vitamin D	50-59	insulin	Homo sapiens	71-78
25993554-5	2015	The DBP variants have different binding coefficients for the vitamin D metabolites, and accordingly there may be important relations between DBP phenotypes and health.	Vitamin D	61-70	D-box binding PAR bZIP transcription factor	Homo sapiens	4-7
25993554-5	2015	The DBP variants have different binding coefficients for the vitamin D metabolites, and accordingly there may be important relations between DBP phenotypes and health.	Vitamin D	61-70	D-box binding PAR bZIP transcription factor	Homo sapiens	141-144
25882890-2	2015	Detection of this biological presentation is frequent in routine practice all the more that PTH reference values established in vitamin D replete subjects with a normal renal function are used by the clinical laboratories.	Vitamin D	128-137	parathyroid hormone	Homo sapiens	92-95
25809484-0	2015	The Active Form of Vitamin D Transcriptionally Represses Smad7 Signaling and Activates Extracellular Signal-regulated Kinase (ERK) to Inhibit the Differentiation of a Inflammatory T Helper Cell Subset and Suppress Experimental Autoimmune Encephalomyelitis.	Vitamin D	19-28	SMAD family member 7	Homo sapiens	57-62
25809484-0	2015	The Active Form of Vitamin D Transcriptionally Represses Smad7 Signaling and Activates Extracellular Signal-regulated Kinase (ERK) to Inhibit the Differentiation of a Inflammatory T Helper Cell Subset and Suppress Experimental Autoimmune Encephalomyelitis.	Vitamin D	19-28	mitogen-activated protein kinase 1	Homo sapiens	87-124
25809484-0	2015	The Active Form of Vitamin D Transcriptionally Represses Smad7 Signaling and Activates Extracellular Signal-regulated Kinase (ERK) to Inhibit the Differentiation of a Inflammatory T Helper Cell Subset and Suppress Experimental Autoimmune Encephalomyelitis.	Vitamin D	19-28	mitogen-activated protein kinase 1	Homo sapiens	126-129
25809484-2	2015	This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression.	Vitamin D	140-149	SMAD family member 7	Homo sapiens	33-37
25809484-2	2015	This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression.	Vitamin D	140-149	SMAD family member 7	Homo sapiens	186-191
25809484-2	2015	This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression.	Vitamin D	140-149	SMAD family member 7	Homo sapiens	208-213
25616026-7	2015	Increased maternal dietary vitamin D was associated with significant increases in IL-10 release by AEC after stimulation with TNF-alpha/IL-1beta (P = 0.024) or HDM (P = 0.049).	Vitamin D	27-36	tumor necrosis factor	Homo sapiens	126-135
25616026-7	2015	Increased maternal dietary vitamin D was associated with significant increases in IL-10 release by AEC after stimulation with TNF-alpha/IL-1beta (P = 0.024) or HDM (P = 0.049).	Vitamin D	27-36	interleukin 1 beta	Homo sapiens	136-144
25134788-0	2015	Vitamin D counteracts fibrogenic TGF-beta signalling in human hepatic stellate cells both receptor-dependently and independently.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	33-41
25640157-14	2015	In vitro, it modulated the IL-8 response to infection in a vitamin D concentration-dependent manner.	Vitamin D	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
25933375-3	2015	Vitamin D might regulate renin-angiotensin-aldosterone system and might be involved in inflammation, both implicated in the pathophysiology of AF.	Vitamin D	0-9	renin	Homo sapiens	25-30
25923487-0	2015	Fortification of Yogurts with Vitamin D and Calcium Enhances the Inhibition of Serum Parathyroid Hormone and Bone Resorption Markers: A Double Blind Randomized Controlled Trial in Women over 60 Living in a Community Dwelling Home.	Vitamin D	30-39	parathyroid hormone	Homo sapiens	85-104
25923487-1	2015	OBJECTIVE: To evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum parathyroid hormone (PTH) and bone resorption markers (BRM) as compared to iso-caloric and iso-protein dairy products in aged white women at risk of fragility fractures.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	129-148
26487877-0	2015	Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients.	Vitamin D	10-19	C-reactive protein	Homo sapiens	52-70
26487877-4	2015	So, in this study, we investigated the effect of Vitamin D supplementation on symptoms and C-reactive protein (CRP) among patients with migraine.	Vitamin D	49-58	C-reactive protein	Homo sapiens	91-109
26487877-4	2015	So, in this study, we investigated the effect of Vitamin D supplementation on symptoms and C-reactive protein (CRP) among patients with migraine.	Vitamin D	49-58	C-reactive protein	Homo sapiens	111-114
25912039-3	2015	The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-gamma, IL-17 and induction of IL-4.	Vitamin D	23-32	interferon gamma	Mus musculus	109-118
25145881-0	2015	Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study.	Vitamin D	7-16	insulin	Homo sapiens	44-51
25145881-0	2015	Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study.	Vitamin D	7-16	insulin	Homo sapiens	88-95
25359323-2	2015	Vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) &lt; 25-30 nmol/l) and sub-optimal status (25(OH)D &lt; 50-100 nmol/l) are increasingly associated with unfavourable metabolic phenotypes, including insulin resistance, type 2 diabetes and CVD; conditions also commonly linked with overweight and obesity.	Vitamin D	0-9	insulin	Homo sapiens	201-208
25582993-3	2015	Since vitamin D exerts important immune-regulatory roles, it has been claimed that derangement of the vitamin D/parathyroid hormone (PTH) system, a well-known determinant of bone health, may play a pathogenic role in autoimmunity; animal models and clinical data support this hypothesis.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	110-131
25998734-5	2015	This phenotypic stability role is facilitated through the ability of vitamin D to increase the expression of both Nrf2 and the anti-ageing protein Klotho, which are also major regulators of Ca(2+) and redox signalling.	Vitamin D	69-78	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
25912039-9	2015	Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-gamma, while inducing IL-4 and IL-10, would be beneficial.	Vitamin D	46-55	interferon gamma	Mus musculus	148-157
25912039-9	2015	Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-gamma, while inducing IL-4 and IL-10, would be beneficial.	Vitamin D	46-55	interleukin 10	Mus musculus	183-188
26413189-0	2015	A vitamin D analog inhibits Th2 cytokine- and TGFbeta -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis.	Vitamin D	2-11	periostin, osteoblast specific factor	Mus musculus	63-72
26413189-4	2015	We investigated whether a vitamin D analog affects the expression of POSTN in dermal fibroblasts and in a BLM-induced scleroderma model.	Vitamin D	26-35	periostin, osteoblast specific factor	Mus musculus	69-74
26413189-11	2015	In addition to the previously reported immunosuppressive effect, the vitamin D analog OCT might be effective to treat scleroderma, in part through inhibition of Th2 cytokine- and TGFbeta-induced POSTN expression.	Vitamin D	69-78	periostin, osteoblast specific factor	Mus musculus	195-200
25312909-0	2015	Modulating effects of WT1 on interferon-beta-vitamin D association in MS.	Vitamin D	45-54	WT1 transcription factor	Homo sapiens	22-25
25312909-10	2015	These findings indicate that WT1 variants may play a role in altering the effects of IFN-beta on vitamin D in MS.	Vitamin D	97-106	WT1 transcription factor	Homo sapiens	29-32
25350782-8	2015	CONCLUSION: The findings of the study showed that the weekly administration of 50 000 IU of oral vitamin D for 8 weeks as an adjunct supplement of antihypertensive drugs in patients with vitamin D deficiency could help prevent vitamin D deficiency and aid control of SBP, DBP, and MAP.	Vitamin D	97-106	D-box binding PAR bZIP transcription factor	Homo sapiens	272-275
25092518-9	2015	Expression of CAMP increased significantly from baseline after 52 weeks of vitamin D-supplementation.	Vitamin D	75-84	cathelicidin antimicrobial peptide	Homo sapiens	14-18
25636720-10	2015	Therefore, measurements of parathyroid hormone (PTH) and vitamin D metabolites 25(OH)D3, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3 are useful to investigate whether the underlying cause of vitamin D toxicity is iatrogenic versus genetic.	Vitamin D	192-201	parathyroid hormone	Homo sapiens	27-46
25644204-14	2015	Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	50-57
25973241-6	2015	The objective of the present study was to explore the relationship between LL-37 plasma levels, vitamin D status and exacerbation risk in patients with COPD.	Vitamin D	96-105	cathelicidin antimicrobial peptide	Homo sapiens	75-80
25801891-10	2015	TNFalpha levels decreased by 54.3% in the group treated with vitamin D and increased by 16.1% in the placebo group.	Vitamin D	61-70	tumor necrosis factor	Homo sapiens	0-8
25293430-2	2015	Apolipoprotein E (APOE) e4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations.	Vitamin D	113-122	apolipoprotein E	Homo sapiens	0-16
25293430-2	2015	Apolipoprotein E (APOE) e4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations.	Vitamin D	113-122	apolipoprotein E	Homo sapiens	18-22
25293430-3	2015	This report aims to examine if the presence of APOE e4 alleles contributes to the relationship between vitamin D and memory function.	Vitamin D	103-112	apolipoprotein E	Homo sapiens	47-51
25230322-0	2015	Vitamin D deficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics.	Vitamin D	0-9	insulin	Homo sapiens	40-47
25230322-0	2015	Vitamin D deficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics.	Vitamin D	0-9	insulin	Homo sapiens	87-94
25230322-8	2015	Endogenous insulin production in response to food intake and in fasting was significantly lower in vitamin D deficient patients with DM compared to those with serum 25(OH)D&gt;40 ng/ml.	Vitamin D	99-108	insulin	Homo sapiens	11-18
25230322-12	2015	Vitamin D deficiency is associated with insulin resistance in nondiabetics, which is independent of obesity.	Vitamin D	0-9	insulin	Homo sapiens	40-47
25230322-13	2015	Furthermore, vitamin D deficiency is associated with reduced insulin production in type 2 diabetics, which was mainly observed in men.	Vitamin D	13-22	insulin	Homo sapiens	61-68
24958015-4	2015	The treatment of C57BL mice with vitamin D significantly preserves postoperative cognitive function, markedly inhibits surgery-induced interleukin (IL)-17, IL-6, transforming growth factor beta (TGF-beta), and retinoic acid-related orphan receptor (RORgammat) production, and obviously induces IL-10 and forkhead box p3 (Foxp3) expression.	Vitamin D	33-42	interleukin 6	Mus musculus	156-160
24958015-4	2015	The treatment of C57BL mice with vitamin D significantly preserves postoperative cognitive function, markedly inhibits surgery-induced interleukin (IL)-17, IL-6, transforming growth factor beta (TGF-beta), and retinoic acid-related orphan receptor (RORgammat) production, and obviously induces IL-10 and forkhead box p3 (Foxp3) expression.	Vitamin D	33-42	interleukin 10	Mus musculus	294-299
25237033-1	2015	Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	161-168
25445919-6	2015	In MCF10DCIS cells treated with vitamin D compounds (1alpha25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced.	Vitamin D	32-41	CD24 molecule	Homo sapiens	153-157
25445919-6	2015	In MCF10DCIS cells treated with vitamin D compounds (1alpha25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced.	Vitamin D	32-41	CD24 molecule	Homo sapiens	178-182
25500070-9	2015	Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect.	Vitamin D	146-155	apolipoprotein A4	Rattus norvegicus	70-75
25541438-0	2015	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.	Vitamin D	57-66	notch receptor 1	Homo sapiens	28-34
25541438-0	2015	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.	Vitamin D	57-66	CD24 molecule	Homo sapiens	101-105
25541438-3	2015	We previously reported that a Gemini vitamin D analog, 1,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluoro-cholecalciferol (BXL0124), reduced CD44(+)/CD24(-/low) cells in MCF10DCIS basal-like breast cancer cells.	Vitamin D	37-46	CD24 molecule	Homo sapiens	193-197
25541438-6	2015	Treatment with the Gemini vitamin D analog BXL0124 decreased the level of activated Notch1 receptor.	Vitamin D	26-35	notch receptor 1	Homo sapiens	84-90
25541438-11	2015	In conclusion, the Gemini vitamin D analog, BXL0124, represses the tumor-initiating subpopulation by HES1-mediated inhibition of Notch1 signaling.	Vitamin D	26-35	notch receptor 1	Homo sapiens	129-135
25597952-5	2015	Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%).	Vitamin D	63-72	BCL2 associated X, apoptosis regulator	Homo sapiens	123-126
25597952-5	2015	Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%).	Vitamin D	63-72	cadherin 1	Homo sapiens	157-167
25597952-5	2015	Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%).	Vitamin D	63-72	calcium sensing receptor	Homo sapiens	192-196
25597952-5	2015	Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%).	Vitamin D	63-72	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	208-215
25770692-6	2015	Some evidence suggests that vitamin D may improve cardiovascular outcomes in diabetes through anti-inflammatory, antioxidative, antihypertrophic, antifibrotic, and antiatherosclerotic activities and by regulating advanced glycation end-product signaling, the renin-angiotensin system, and cardiac metabolism.	Vitamin D	28-37	renin	Homo sapiens	259-264
25795932-0	2015	Vitamin d deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal women.	Vitamin D	0-9	insulin	Homo sapiens	40-47
25795932-3	2015	OBJECTIVES: To investigate the independent relationship of vitamin D deficiency with insulin resistance, lipid profile, inflammatory status, blood pressure and endothelial function.	Vitamin D	59-68	insulin	Homo sapiens	85-92
25795932-10	2015	CONCLUSIONS: The findings of the present study suggest that vitamin D deficiency is associated with insulin resistance independent of dietary calcium, intracellular calcium and serum levels of parathormone, calcitriol and calcium in healthy premenopausal women.	Vitamin D	60-69	insulin	Homo sapiens	100-107
26204641-7	2015	Vitamin D deficiency may mask hypercalcemia despite high serum PTH levels, and does not seem to diminish but on the contrary increases the risk of kidney lithiasis, as well as the deleterious effects of hyperparathyroidism on bone.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	63-66
25866591-4	2015	The mechanisms by which vitamin D exerts its cardiovascular protective effects are still not completely understood, but there is evidence that it participates in the regulation of renin-angiotensin system and the mechanisms of insulin sensitivity and activity of inflammatory cytokines, besides its direct cardiovascular actions.	Vitamin D	24-33	renin	Homo sapiens	180-185
25866591-4	2015	The mechanisms by which vitamin D exerts its cardiovascular protective effects are still not completely understood, but there is evidence that it participates in the regulation of renin-angiotensin system and the mechanisms of insulin sensitivity and activity of inflammatory cytokines, besides its direct cardiovascular actions.	Vitamin D	24-33	insulin	Homo sapiens	227-234
25092518-10	2015	At this time point, TLR2/1L-induced CAMP was positively associated with percent change from baseline in 25OHD (p=0.029 overall and 0.002 within vitamin D-supplemented only).	Vitamin D	144-153	toll like receptor 2	Homo sapiens	20-27
25092518-10	2015	At this time point, TLR2/1L-induced CAMP was positively associated with percent change from baseline in 25OHD (p=0.029 overall and 0.002 within vitamin D-supplemented only).	Vitamin D	144-153	cathelicidin antimicrobial peptide	Homo sapiens	36-40
25890042-1	2015	BACKGROUND: Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D]; this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures.	Vitamin D	12-21	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
25730676-1	2015	1,25 Dihydroxyvitamin D3 (1,25D) is a hormone produced from vitamin D through two hydroxylating steps catalyzed successively in the liver by the vitamin D 25-hydroxylase Cyp2R1 and in the kidney by the 25-hydroxyvitamin D3 1alpha-hydroxylase Cyp27B1.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	202-241
25730676-1	2015	1,25 Dihydroxyvitamin D3 (1,25D) is a hormone produced from vitamin D through two hydroxylating steps catalyzed successively in the liver by the vitamin D 25-hydroxylase Cyp2R1 and in the kidney by the 25-hydroxyvitamin D3 1alpha-hydroxylase Cyp27B1.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	242-249
25890042-1	2015	BACKGROUND: Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D]; this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures.	Vitamin D	97-106	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
25890042-3	2015	We aimed to investigate the influence of DBP gene polymorphism on the relationship of vitamin D status and fetuin-A levels to BMD and bone markers.	Vitamin D	86-95	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
25890042-12	2015	CONCLUSIONS: The interaction between vitamin D status, as measured by circulating 25(OH)D and DBP rs2282679 genotypes, modified the association between 25(OH)D and BMD and bone markers.	Vitamin D	37-46	D-box binding PAR bZIP transcription factor	Homo sapiens	94-97
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	calcium sensing receptor	Homo sapiens	103-107
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-71
25852682-0	2015	Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease.	Vitamin D	0-9	CD4 molecule	Homo sapiens	21-24
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	CD4 molecule	Homo sapiens	235-238
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	CD4 molecule	Homo sapiens	264-267
25680585-4	2015	Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) genes in MS patients.	Vitamin D	53-62	transforming growth factor beta 1	Homo sapiens	121-153
25680585-4	2015	Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) genes in MS patients.	Vitamin D	53-62	transforming growth factor beta 1	Homo sapiens	155-164
25773149-1	2015	BACKGROUND: Deficiency of vitamin D is an environmental risk factor for MS. Vitamin D has immunomodulatory effects, including promotion of T-cell differentiation into T-regulatory cells, which produces regulatory cytokines including TGF-beta.	Vitamin D	26-35	transforming growth factor beta 1	Homo sapiens	233-241
25773149-1	2015	BACKGROUND: Deficiency of vitamin D is an environmental risk factor for MS. Vitamin D has immunomodulatory effects, including promotion of T-cell differentiation into T-regulatory cells, which produces regulatory cytokines including TGF-beta.	Vitamin D	76-85	transforming growth factor beta 1	Homo sapiens	233-241
25773149-6	2015	RESULTS: LAP (TGF-beta) levels increased significantly in the vitamin D treated group from a mean of 47 (SE 11) pg/ml to 55 (SE 14) pg/ml in 12 months (p-value=0.0249).	Vitamin D	62-71	transforming growth factor beta 1	Homo sapiens	14-22
25773149-10	2015	The immune regulatory effects of TGF-beta may play a role in the improved MRI outcomes that we observed earlier in the vitamin D treated group of patients.	Vitamin D	119-128	transforming growth factor beta 1	Homo sapiens	33-41
25773153-0	2015	GM-CSF production by CD4+ T cells in MS patients: regulation by regulatory T cells and vitamin D.	Vitamin D	87-96	CD4 molecule	Homo sapiens	21-24
25886311-9	2015	Plasma PTH levels in the children with hypovitaminosis D were significantly higher than in the children with normal levels of vitamin D (4.34 +- 1.38 vs 3.78 +- 1.25 pmol/L; P-value = 0.04).	Vitamin D	126-135	parathyroid hormone	Homo sapiens	7-10
24658164-1	2015	Vitamin D deficiency is associated with cardiometabolic risk factors (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia).	Vitamin D	0-9	insulin	Homo sapiens	88-95
24658164-4	2015	There was a negative correlation between vitamin D level and anthropometric indicators of obesity: BMI (r = -0.64; P &lt; .001), waist circumference (r = -0.59; P &lt; .001), and body fat percentage (r = -0.64; P &lt; .001) as well as with fasting plasma insulin (r = -0.35; P &lt; .001) and homeostasis model assessment of insulin resistance (r = -0.35; P &lt; .001).	Vitamin D	41-50	insulin	Homo sapiens	255-262
24658164-4	2015	There was a negative correlation between vitamin D level and anthropometric indicators of obesity: BMI (r = -0.64; P &lt; .001), waist circumference (r = -0.59; P &lt; .001), and body fat percentage (r = -0.64; P &lt; .001) as well as with fasting plasma insulin (r = -0.35; P &lt; .001) and homeostasis model assessment of insulin resistance (r = -0.35; P &lt; .001).	Vitamin D	41-50	insulin	Homo sapiens	324-331
25750305-8	2015	Patients with positive nuclear p53 had significantly lower vitamin D levels (4.18 ng/ml), compared to patients without nuclear p53 expression.	Vitamin D	59-68	tumor protein p53	Homo sapiens	31-34
25664429-2	2015	Vitamin D (vit.D) has beneficial effects not only on bone metabolism but also on the function of the immune system.	Vitamin D	0-9	vitrin	Homo sapiens	11-14
25716810-3	2015	In the classical view of calcium metabolism, vitamin D is activated by CYP27B1 in the kidney and promotes calcium absorption in the intestine as a hormone.	Vitamin D	45-54	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	71-78
25716810-4	2015	Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types.	Vitamin D	31-40	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	99-106
24797104-9	2015	Female gender and high C-reactive protein (CRP) were associated with vitamin D deficiency in anemic group.	Vitamin D	69-78	C-reactive protein	Homo sapiens	23-41
25636811-1	2015	PURPOSE: We tested whether short-term vitamin D supplementation improves insulin resistance in patients with kidney disease, a condition with little intrinsic vitamin D activity.	Vitamin D	38-47	insulin	Homo sapiens	73-80
25636811-8	2015	Among RCTs, compared to placebo, vitamin D supplementation was associated with significant decrease in fasting glucose [SMD -1.13, (-2.11 to -0.11)] and PTH levels [SMD -1.50, (-2.95 to -0.04)] but no difference in fasting insulin levels [SMD 1.32, (-0.15 to 2.79)].	Vitamin D	33-42	parathyroid hormone	Homo sapiens	153-156
25636811-8	2015	Among RCTs, compared to placebo, vitamin D supplementation was associated with significant decrease in fasting glucose [SMD -1.13, (-2.11 to -0.11)] and PTH levels [SMD -1.50, (-2.95 to -0.04)] but no difference in fasting insulin levels [SMD 1.32, (-0.15 to 2.79)].	Vitamin D	33-42	insulin	Homo sapiens	223-230
25636811-9	2015	Among NRIS, there was only a significant decrease in PTH levels [SMD -1.68, (-2.55 to -0.82)] between pre- and post-vitamin D treatment levels.	Vitamin D	116-125	parathyroid hormone	Homo sapiens	53-56
24797104-9	2015	Female gender and high C-reactive protein (CRP) were associated with vitamin D deficiency in anemic group.	Vitamin D	69-78	C-reactive protein	Homo sapiens	43-46
25201000-1	2015	OBJECTIVE: The aims of the present study were to examine gene and protein expression of the vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzyme in human papillary thyroid cancer (PTC), furthermore, to investigate the association between CYP24A1 expression and numerous clinical, histological parameters and somatic oncogene mutation status of thyroid tumor tissues.	Vitamin D	92-101	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	179-186
25954674-2	2015	Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin.	Vitamin D	49-58	insulin	Homo sapiens	89-96
25294851-1	2015	BACKGROUND: In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-alpha (TGFalpha) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid hormone (PTH) and also reductions in vitamin D receptor (VDR) that limit vitamin D suppression of SHPT.	Vitamin D	255-264	tumor necrosis factor	Homo sapiens	84-116
25448751-14	2015	Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	50-57
25294851-8	2015	Importantly, in rat SHPT, the correction of vitamin D deficiency effectively reversed the resistance to paricalcitol induction of C/EBPbeta to suppress ADAM17 expression and PTG enlargement, reducing PTH by 50%.	Vitamin D	44-53	ADAM metallopeptidase domain 17	Rattus norvegicus	152-158
25294851-1	2015	BACKGROUND: In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-alpha (TGFalpha) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid hormone (PTH) and also reductions in vitamin D receptor (VDR) that limit vitamin D suppression of SHPT.	Vitamin D	255-264	epidermal growth factor receptor	Homo sapiens	137-149
25294851-8	2015	Importantly, in rat SHPT, the correction of vitamin D deficiency effectively reversed the resistance to paricalcitol induction of C/EBPbeta to suppress ADAM17 expression and PTG enlargement, reducing PTH by 50%.	Vitamin D	44-53	parathyroid hormone	Rattus norvegicus	200-203
25294851-9	2015	CONCLUSION: In SHPT, correction of vitamin D and calcitriol deficiency induces parathyroid C/EBPbeta to efficaciously attenuate the severe ADAM17/TGFalpha synergy, which drives PTG enlargement and high PTH.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	202-205
25294851-1	2015	BACKGROUND: In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-alpha (TGFalpha) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid hormone (PTH) and also reductions in vitamin D receptor (VDR) that limit vitamin D suppression of SHPT.	Vitamin D	255-264	epidermal growth factor receptor	Homo sapiens	151-155
25722966-4	2015	METHODS: Two authors independently searched Medline and PubMed for longitudinal studies that had assessed the effect of vitamin D supplements on glycemic control, insulin resistance and beta-cell dysfunction in patients with diabetes.	Vitamin D	120-129	insulin	Homo sapiens	163-170
25366373-0	2015	Associations between the levels of sclerostin, phosphate, and fibroblast growth factor-23 and treatment with vitamin D in hemodialysis patients with low intact PTH level.	Vitamin D	109-118	sclerostin	Homo sapiens	35-45
25887335-7	2015	CONCLUSION: Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.	Vitamin D	46-55	insulin	Homo sapiens	152-159
25542806-2	2015	Recently, variants of vitamin D metabolizing genes, including rs12368653, rs10876994, rs118204009 and rs703842 in CYP27B1, and rs2248359 in CYP24A1 have been identified to be associated with the pathogenicity of MS in Caucasian populations.	Vitamin D	22-31	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	114-121
25737638-0	2015	Effect of vitamin D therapy on interleukin-6, visfatin, and hyaluronic acid levels in chronic hepatitis C Egyptian patients.	Vitamin D	10-19	interleukin 6	Homo sapiens	31-44
25519225-0	2015	Genetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling.	Vitamin D	139-148	tumor protein p53	Homo sapiens	20-23
25722966-6	2015	Results of the various short-term studies (follow up &lt;= 3 months) suggested that vitamin D supplementation had a positive impact on glycemic control and metabolic parameters such as insulin resistance and beta cell dysfunction.	Vitamin D	84-93	insulin	Homo sapiens	185-192
25667511-0	2015	Vitamin D inhibits ovarian cancer cell line proliferation in combination with celecoxib and suppresses cyclooxygenase-2 expression.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-119
25138785-10	2015	The most insulin-resistant quartile of subjects had the lowest 25(OH)D concentration and the most adverse CVD risk profile, and they may be the subset of patients with essential hypertension most likely to benefit from vitamin D repletion.	Vitamin D	219-228	insulin	Homo sapiens	9-16
25673925-0	2015	Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	69-74
25241299-0	2015	Improved clinical outcomes associated with vitamin D supplementation during adjuvant chemotherapy in patients with HER2+ nonmetastatic breast cancer.	Vitamin D	43-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-119
25241299-1	2015	BACKGROUND: Vitamin D (VD) supplementation has pleiotropic effects that extend beyond their impact on bone health, including the disruption of downstream VD receptor signaling and human epidermal growth factor receptor 2 (HER2) signaling through the ErbB2/AKT/ERK pathway.	Vitamin D	12-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	186-220
25241299-1	2015	BACKGROUND: Vitamin D (VD) supplementation has pleiotropic effects that extend beyond their impact on bone health, including the disruption of downstream VD receptor signaling and human epidermal growth factor receptor 2 (HER2) signaling through the ErbB2/AKT/ERK pathway.	Vitamin D	12-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	222-226
25241299-1	2015	BACKGROUND: Vitamin D (VD) supplementation has pleiotropic effects that extend beyond their impact on bone health, including the disruption of downstream VD receptor signaling and human epidermal growth factor receptor 2 (HER2) signaling through the ErbB2/AKT/ERK pathway.	Vitamin D	12-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	250-255
25241299-1	2015	BACKGROUND: Vitamin D (VD) supplementation has pleiotropic effects that extend beyond their impact on bone health, including the disruption of downstream VD receptor signaling and human epidermal growth factor receptor 2 (HER2) signaling through the ErbB2/AKT/ERK pathway.	Vitamin D	12-21	AKT serine/threonine kinase 1	Homo sapiens	256-259
25241299-1	2015	BACKGROUND: Vitamin D (VD) supplementation has pleiotropic effects that extend beyond their impact on bone health, including the disruption of downstream VD receptor signaling and human epidermal growth factor receptor 2 (HER2) signaling through the ErbB2/AKT/ERK pathway.	Vitamin D	12-21	mitogen-activated protein kinase 1	Homo sapiens	260-263
25336462-9	2015	Adding biomarkers to the models to test for mediation, the vitamin D effect on respiratory health was not a consequence of any single marker but was partially attenuated as a combined result of leukocytes, AP, and CRP.	Vitamin D	59-68	C-reactive protein	Homo sapiens	214-217
25510482-0	2015	Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells.	Vitamin D	39-48	cathelicidin antimicrobial peptide	Homo sapiens	122-127
25510482-2	2015	We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37 in granulomatous lesions compared to distal parenchyma from the infected lung.	Vitamin D	49-58	cathelicidin antimicrobial peptide	Homo sapiens	158-163
25634511-22	2015	We found a baseline level of vitamin D that was 10 nmol/l higher was associated with a small but statistically significant decrease in UACR by 0.92% (p = 0.02), but a non-significantly lower PTH.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	191-194
25510482-2	2015	We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37 in granulomatous lesions compared to distal parenchyma from the infected lung.	Vitamin D	116-125	cathelicidin antimicrobial peptide	Homo sapiens	158-163
25078430-5	2015	A C/EBP binding site was identified at -627/-619 within the CAMP promoter, adjacent to the vitamin D response element (VDRE; -615/-600).	Vitamin D	91-100	cathelicidin antimicrobial peptide	Homo sapiens	60-64
25271011-2	2015	This study investigated whether high-dose vitamin D3 given once to healthy adults before winter will (1) prevent the wintertime decline in vitamin D status, (2) promote vitamin D sufficiency 1 year following the dose and (3) prevent the rise of parathyroid hormone (PTH) concentrations.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	245-264
24790215-7	2015	IFN-gamma"s effects on relapse were greatly attenuated by immunomodulatory therapies, by summer season and by higher serum vitamin D, whereas TNF-alpha"s inverse association with relapse was only present in these circumstances.	Vitamin D	123-132	interferon gamma	Homo sapiens	0-9
25195551-0	2015	Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis.	Vitamin D	16-25	insulin	Homo sapiens	31-38
24790215-9	2015	CONCLUSIONS: We found strong effects of IFN-gamma and TNF-alpha on relapse risk, these differing by immunomodulatory therapy, season, and serum vitamin D, as well as by genotype.	Vitamin D	144-153	interferon gamma	Homo sapiens	40-49
24790215-9	2015	CONCLUSIONS: We found strong effects of IFN-gamma and TNF-alpha on relapse risk, these differing by immunomodulatory therapy, season, and serum vitamin D, as well as by genotype.	Vitamin D	144-153	tumor necrosis factor	Homo sapiens	54-63
25501638-10	2015	In summary, our results suggest that local expression of CYP27B1 in ovarian tumor cells can modify their behavior and promote a less aggressive phenotype by affecting local concentrations of active of vitamin D levels within the tumor microenvironment.	Vitamin D	201-210	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	57-64
25644349-1	2015	BACKGROUND: There is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes.	Vitamin D	73-82	insulin	Homo sapiens	150-157
25645983-0	2015	Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps.	Vitamin D	0-9	C-C motif chemokine ligand 11	Homo sapiens	37-44
25645983-4	2015	In this study, we investigated the effect of vitamin D derivatives (calcitriol and tacalcitol) on the secretion of eotaxin and Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES), the two major eosinophil chemoattractants, in fibroblasts derived from the polyps of Taiwanese CRSwNP patients.	Vitamin D	45-54	C-C motif chemokine ligand 11	Homo sapiens	115-122
25645983-12	2015	Therefore, the inhibitory effect of vitamin D derivatives on eotaxin and RANTES secretion might shed light not only on the disease mechanism, but also on the potential use of vitamin D in pharmacotherapy of Taiwanese patients with CRSwNP.	Vitamin D	36-45	C-C motif chemokine ligand 11	Homo sapiens	61-68
25499095-4	2015	This study was to explore the correlation between serum calcium and CGRP in coronary artery disease (CAD), and observe whether short-term calcium/vitamin D supplementation would increase fasting serum CGRP.	Vitamin D	146-155	calcitonin related polypeptide alpha	Homo sapiens	201-205
25630909-1	2015	BACKGROUND: We tested the controversial hypothesis that vitamin D depletion aggravates hypertension and target-organ damage by influencing renin.	Vitamin D	56-65	renin	Homo sapiens	139-144
25630909-5	2015	Furthermore, the mRNAs of natriuretic peptides, neutrophil gelatinase-associated lipocalin, hREN, and rRen were increased by vitamin D depletion.	Vitamin D	125-134	renin	Homo sapiens	92-96
25630909-9	2015	Our data suggest that even short-term severe vitamin D deficiency may directly promote hypertension and impacts on renin-angiotensin system components that could contribute to target-organ damage.	Vitamin D	45-54	renin	Homo sapiens	115-120
26439891-1	2015	BACKGROUND: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT).	Vitamin D	102-111	parathyroid hormone	Homo sapiens	148-167
26004987-0	2015	Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men.	Vitamin D	0-9	sex hormone binding globulin	Homo sapiens	66-94
26004987-10	2015	Total testosterone and SHBG values displayed an increasing trend from subjects with vitamin D deficiency to those with optimal level (p &lt; 0.05).	Vitamin D	84-93	sex hormone binding globulin	Homo sapiens	23-27
25785055-9	2015	In this study, a clear association between vitamin D and vitamin B12 treatment and epilepsy was identified.	Vitamin D	43-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	65-68
26168767-2	2015	In 43.6 % of the sample, levels of vitamin D were below 20 ng/mL and showed an inverse relationship with parathyroid hormone (PTH; p &lt; 0.01).	Vitamin D	35-44	parathyroid hormone	Homo sapiens	105-124
26168767-2	2015	In 43.6 % of the sample, levels of vitamin D were below 20 ng/mL and showed an inverse relationship with parathyroid hormone (PTH; p &lt; 0.01).	Vitamin D	35-44	parathyroid hormone	Homo sapiens	126-129
26218841-1	2015	LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple activities including a mediator of vitamin D-induced autophagy in human macrophages, resulting in intracellular killing of Mycobacterium tuberculosis (Mtb).	Vitamin D	121-130	cathelicidin antimicrobial peptide	Homo sapiens	0-5
25695075-1	2015	Single nucleotide polymorphisms (SNPs), R990G and A986S of the calcium sensing receptor (CaSR) gene, are shown to influence response of parathyroid hormone (PTH) in subjects with optimal vitamin D levels.	Vitamin D	187-196	calcium sensing receptor	Homo sapiens	63-87
26000280-3	2015	The antihypertensive properties of vitamin D include suppression of the renin-angiotensin-aldosterone system, renoprotective effects, direct effects on endothelial cells and calcium metabolism, inhibition of growth of vascular smooth muscle cells, prevention of secondary hyperparathyroidism, and beneficial effects on cardiovascular risk factors.	Vitamin D	35-44	renin	Homo sapiens	72-77
26000280-7	2015	Vitamin D supplementation should further consider additional factors, such as phosphates, parathormone, renin, and fibroblast growth factor 23 levels.	Vitamin D	0-9	renin	Homo sapiens	104-109
26000281-3	2015	Recently, evidence has been collected to suggest that, beyond the traditional involvement in mineral metabolism, vitamin D may interact with other kidney hormones such as renin and erythropoietin.	Vitamin D	113-122	renin	Homo sapiens	171-176
26000281-3	2015	Recently, evidence has been collected to suggest that, beyond the traditional involvement in mineral metabolism, vitamin D may interact with other kidney hormones such as renin and erythropoietin.	Vitamin D	113-122	erythropoietin	Homo sapiens	181-195
25695075-1	2015	Single nucleotide polymorphisms (SNPs), R990G and A986S of the calcium sensing receptor (CaSR) gene, are shown to influence response of parathyroid hormone (PTH) in subjects with optimal vitamin D levels.	Vitamin D	187-196	calcium sensing receptor	Homo sapiens	89-93
25695075-1	2015	Single nucleotide polymorphisms (SNPs), R990G and A986S of the calcium sensing receptor (CaSR) gene, are shown to influence response of parathyroid hormone (PTH) in subjects with optimal vitamin D levels.	Vitamin D	187-196	parathyroid hormone	Homo sapiens	136-155
26051386-9	2015	CONCLUSION: Vitamin D deficiency was independently associated with an increased time to decline in CD4 cell count to &lt;350 cells/microL, but not with a change in CD4 overall in people with HIV not receiving ART.	Vitamin D	12-21	CD4 molecule	Homo sapiens	99-102
26858840-0	2015	Reduction of Parathyroid Hormone with Vitamin D Supplementation in Blacks: A Randomized Controlled Trial.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	13-32
26858840-1	2015	BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	24-43
26858840-1	2015	BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status.	Vitamin D	133-142	parathyroid hormone	Homo sapiens	24-43
29421501-1	2015	BACKGROUND: Vitamin D dependent rickets type I is a rare hereditary disease due to a mutation in CYP27B1 encoding the 1alpha-hydroxylase gene.	Vitamin D	12-21	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	97-104
26695423-1	2015	OBJECTIVE: To determine whether vitamin D supplementation improves non-traditional cardiovascular risk factors such as Apo B levels among indigenous children.	Vitamin D	32-41	apolipoprotein B	Homo sapiens	119-124
26695423-8	2015	Several multiple regression linear analyses showed that changes in vitamin D were significantly associated with lower LDL-C levels (Beta- 0.41, p&lt;0.01; R2 0.07); and with lower Apo B levels (Beta-0.37, p&lt;0.01; R2 0.17).	Vitamin D	67-76	apolipoprotein B	Homo sapiens	180-185
26695423-9	2015	CONCLUSION: Vitamin D supplementation among indigenous children could improve Apo B levels.	Vitamin D	12-21	apolipoprotein B	Homo sapiens	78-83
26051386-3	2015	We therefore evaluated effects of vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] &lt;50 nmol/L) on the decline in CD4 cell count in people with HIV not receiving ART.	Vitamin D	34-43	CD4 molecule	Homo sapiens	125-128
26051386-5	2015	A proportional hazards model was fitted to evaluate the effect of vitamin D status on the time to decline in CD4 cell count (&lt;350 cells/microL), adjusted for nadir CD4 cell count, time since HIV diagnosis, previous ART use and HIVviral load.	Vitamin D	66-75	CD4 molecule	Homo sapiens	109-112
25284246-5	2015	Two brothers with VDDR1A were recruited who had null mutations of CYP27B1 which encodes 1-alpha-hydroxylase of vitamin D.	Vitamin D	111-120	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	66-73
26051386-8	2015	HIV-infected individuals with vitamin D deficiency had an increased risk of CD4 decline to &lt;350 cells/microL [Hazard ratio (HR) 2.15 (95% CI 1.05, 4.38, p=0.04)].	Vitamin D	30-39	CD4 molecule	Homo sapiens	76-79
25100378-3	2015	In this study, we examined the association between vitamin D and parathyroid hormone (PTH) levels and HF in and elderly population in China.	Vitamin D	51-60	parathyroid hormone	Homo sapiens	65-84
26153248-1	2015	Vitamin D affects a range of pathophysiological processes pertinent to the control of blood pressure, including endothelial function, inflammation and renin-angiotensin system activity.	Vitamin D	0-9	renin	Homo sapiens	151-156
25100378-3	2015	In this study, we examined the association between vitamin D and parathyroid hormone (PTH) levels and HF in and elderly population in China.	Vitamin D	51-60	parathyroid hormone	Homo sapiens	86-89
25396269-8	2015	Our data indicate that out of the variants in 29 different genes analyzed, variants of 11 genes, including EXOC2, TYR, and TYRP1, have the highest impact on vitamin D status.	Vitamin D	157-166	tyrosinase related protein 1	Homo sapiens	123-128
26159447-5	2015	Vitamin D sterols reduce parathyroid hormone (PTH) secretion while normalizing calcium (Ca) and vitamin D levels.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	25-44
25705243-6	2015	PTH (1-84) has been demonstrated to maintain serum calcium while reducing or eliminating requirements for calcium and active vitamin D supplementation.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	0-3
26431089-3	2015	Growing evidence has suggested that vitamin D deficiency is implicated in the pathogenesis of insulin resistance and the development of metabolic disorders in the polycystic ovary syndrome.	Vitamin D	36-45	insulin	Homo sapiens	94-101
25359317-6	2015	However in patients with vitamin D deficiency, a significant proportion had PTH, calcium, phosphate and alkaline phosphatase levels within the laboratory normal range.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	76-79
25689747-3	2015	In particular, vitamin D deficiency is associated with an increase in conditions such as obesity, insulin-resistance, hypertension, diabetes, and an increased risk of death from these pathologies.	Vitamin D	15-24	insulin	Homo sapiens	98-105
25584176-12	2015	CONCLUSION: Oral supplementation vitamin D3 significantly increased serum vitamin D levels and insignificantly reduced serum TNF-alpha level.	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	125-134
25359317-6	2015	However in patients with vitamin D deficiency, a significant proportion had PTH, calcium, phosphate and alkaline phosphatase levels within the laboratory normal range.	Vitamin D	25-34	alkaline phosphatase, placental	Homo sapiens	104-124
26780278-0	2015	A Vitamin D-Calcium-Fortified Yogurt Drink Decreased Serum PTH but did not Affect Osteocalcin in Subjects with Type 2 Diabetes.	Vitamin D	2-11	parathyroid hormone	Homo sapiens	59-62
26161090-0	2015	Vitamin D Status and VDR Genotype in NF1 Patients: A Case-Control Study from Southern Brazil.	Vitamin D	0-9	neurofibromin 1	Homo sapiens	37-40
26161090-1	2015	Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population.	Vitamin D	64-73	neurofibromin 1	Homo sapiens	0-24
26161090-1	2015	Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared to the general population.	Vitamin D	64-73	neurofibromin 1	Homo sapiens	26-29
26504859-1	2015	OBJECTIVES: To assess zinc (Zn) and vitamin D (Vit.	Vitamin D	36-45	vitrin	Homo sapiens	47-50
26598844-2	2015	Vitamin D affects the cardiovascular system via several pathways, such as suppression of parathyroid hormone, the renin- angiotensin-aldosterone system and vascular endothelial growth and the immune system.	Vitamin D	0-9	renin	Homo sapiens	114-119
26166951-9	2015	A significant correlation between total TREM-2 expression and vitamin D levels has been detected too.	Vitamin D	62-71	triggering receptor expressed on myeloid cells 2	Homo sapiens	40-46
25516505-7	2015	Performing Mc-Nemar test, we found a statistical significant correlation between low serum levels of vitamin D in ST-MM and low percentage of BRAF mutation (p = 0.03), as well as between serum levels of vitamin D and high percentage of BRAF mutation in NST-MM (p &lt; 0.001).	Vitamin D	101-110	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	142-146
25516505-7	2015	Performing Mc-Nemar test, we found a statistical significant correlation between low serum levels of vitamin D in ST-MM and low percentage of BRAF mutation (p = 0.03), as well as between serum levels of vitamin D and high percentage of BRAF mutation in NST-MM (p &lt; 0.001).	Vitamin D	203-212	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	236-240
26739673-2	2015	The aim of this study was to evaluate the serum vitamin D level in asthmatics with different phenotypes and to determine its associations with lung function, IgE, eosinophil count and body mass index (BMI).	Vitamin D	48-57	immunoglobulin heavy constant epsilon	Homo sapiens	158-161
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	4-13	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	175-182
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	175-182
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	175-182
25541958-1	2014	BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis.	Vitamin D	62-71	D-box binding PAR bZIP transcription factor	Homo sapiens	146-149
26068724-3	2015	The aim of this study was to elucidate which factor, FGF-23 or PTH, plays a more important role in the regulation of vitamin D metabolites in subjects with estimated glomerular filtration (eGFR) &gt;=60 ml/min/1.73 m(2).	Vitamin D	117-126	parathyroid hormone	Homo sapiens	63-66
25470522-8	2015	Moreover, osteocalcin also influences phosphate metabolism via osteocyte-derived FGF23 (which targets the kidneys and parathyroid glands to control phosphate reabsorption and metabolism of vitamin D).	Vitamin D	189-198	bone gamma-carboxyglutamate protein	Homo sapiens	10-21
25476363-3	2015	The synthesis of osteocalcin by osteoblasts is regulated by the active form of vitamin D.	Vitamin D	79-88	bone gamma-carboxyglutamate protein	Homo sapiens	17-28
25522365-7	2014	Use cases presented herein cover 1) the comprehensive identification of chemical matter for a dopamine receptor drug discovery program 2) the identification of compounds active against all targets in the Epidermal growth factor receptor (ErbB) signaling pathway that have a relevance to disease and 3) the evaluation of established targets in the Vitamin D metabolism pathway to aid novel Vitamin D analogue design.	Vitamin D	347-356	epidermal growth factor receptor	Homo sapiens	238-242
25549329-9	2014	Adjustment for PD cell CD14/CD45 expression using a mixed linear statistical model also revealed increased expression of CAMP (mRNA in PD cells and protein in effluent) in vitamin D-supplemented patients.	Vitamin D	172-181	cathelicidin antimicrobial peptide	Homo sapiens	121-125
25522365-7	2014	Use cases presented herein cover 1) the comprehensive identification of chemical matter for a dopamine receptor drug discovery program 2) the identification of compounds active against all targets in the Epidermal growth factor receptor (ErbB) signaling pathway that have a relevance to disease and 3) the evaluation of established targets in the Vitamin D metabolism pathway to aid novel Vitamin D analogue design.	Vitamin D	389-398	epidermal growth factor receptor	Homo sapiens	238-242
25514561-1	2014	An increasing number of studies report associations between low serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance; however, whether low vitamin D levels directly contribute to increased insulin resistance is unclear.	Vitamin D	80-89	insulin	Homo sapiens	110-117
25324546-8	2014	These findings indicate that the SWI/SNF complex and PRMT5 may be key factors involved in regulation of 1,25(OH)2D3 catabolism and therefore in the maintenance of calcium homeostasis by vitamin D.	Vitamin D	186-195	protein arginine methyltransferase 5	Homo sapiens	53-58
25538936-0	2014	Results of the META-Health Study Suggest Pathways by Which Vitamin D Affect Obesity and Cardiovascular Risk through Adiponectin Levels may Require Further Characterization in Subgroups.	Vitamin D	59-68	adiponectin, C1Q and collagen domain containing	Homo sapiens	116-127
26579418-1	2014	Cytochrome P450 (CYP) enzymes metabolize numerous endogenous substrates, such as retinoids, androgens, estrogens and vitamin D, that can modulate important cellular processes, including proliferation, differentiation and apoptosis.	Vitamin D	117-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
26579418-1	2014	Cytochrome P450 (CYP) enzymes metabolize numerous endogenous substrates, such as retinoids, androgens, estrogens and vitamin D, that can modulate important cellular processes, including proliferation, differentiation and apoptosis.	Vitamin D	117-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
25423925-4	2014	However, in CKD, PTH hypersecretion and hyperplasia are started by hyperphosphatemia, hypocalcemia, and activated-vitamin-D deficiency, and the secondary hyperparathyroidism develops.	Vitamin D	114-123	parathyroid hormone	Homo sapiens	17-20
24451003-6	2014	TXNIP expression was stimulated by vitamin D exposure and by transfection.	Vitamin D	35-44	thioredoxin interacting protein	Homo sapiens	0-5
25442486-1	2014	BACKGROUND: The purpose of this study was to determine the prevalence of vitamin D deficiency in CTCL patients and whether supplementation corrects vitamin D deficiency or treatment outcome.	Vitamin D	73-82	TSPY like 2	Homo sapiens	97-101
25442486-11	2014	CONCLUSION: To our knowledge,this is the first study of vitamin D status in CTCL patients.	Vitamin D	56-65	TSPY like 2	Homo sapiens	76-80
25442486-12	2014	Vitamin D deficiency was present in CTCL and other cancer patients compared with normal and historical controls.	Vitamin D	0-9	TSPY like 2	Homo sapiens	36-40
26171357-0	2014	The Effects of Vitamin D Supplementation on Glucose Control and Insulin Resistance in Patients with Diabetes Type 2: A Randomized Clinical Trial Study.	Vitamin D	15-24	insulin	Homo sapiens	64-71
26171357-1	2014	BACKGROUND: Vitamin D deficiency is prevalent in diabetes type 2 and this vitamin may be related to insulin action.	Vitamin D	12-21	insulin	Homo sapiens	100-107
26171357-4	2014	The effect of vitamin D on glucose control was assessed by measuring HbA1c and insulin resistance as HOMA-IR at the baseline and the end of the intervention.	Vitamin D	14-23	insulin	Homo sapiens	79-86
26171357-5	2014	RESULTS: The results showed a significant decrease in HbA1c (from 7.29 +- 0.22 % to 6.76 +- 0.18 %, P&lt;0.001) and insulin concentration (from 8.24 +- 0.97 muIU/mL to 6.55 +- 0.28 muIU/mL, P=0.048), but a non-significant decrease in HOMA-IR in vitamin D group.	Vitamin D	245-254	insulin	Homo sapiens	116-123
25215557-9	2014	Individuals who received joint calcium-vitamin D supplements tended to have a decrease in serum high-sensitivity C-reactive protein levels compared with placebo after controlling for baseline levels (-1.14 +- 0.25 vs 0.02 +- 0.24 ng/mL, P = .09).	Vitamin D	39-48	C-reactive protein	Homo sapiens	113-131
25215557-10	2014	CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes.	Vitamin D	26-35	interleukin 6	Homo sapiens	107-111
25202819-0	2014	Vitamin D and parathyroid hormone status in pregnancy: effect on insulin sensitivity, beta-cell function, and gestational diabetes mellitus.	Vitamin D	0-9	insulin	Homo sapiens	65-72
25215557-10	2014	CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes.	Vitamin D	26-35	tumor necrosis factor	Homo sapiens	116-125
25202819-3	2014	OBJECTIVE: This study sought to evaluate the effect of vitamin D and PTH status on insulin sensitivity, beta-cell function, and glycemia in pregnancy.	Vitamin D	55-64	insulin	Homo sapiens	83-90
25215557-10	2014	CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes.	Vitamin D	144-153	interleukin 6	Homo sapiens	107-111
25215557-10	2014	CONCLUSION: Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-alpha concentrations in vitamin D-insufficient people with type 2 diabetes.	Vitamin D	144-153	tumor necrosis factor	Homo sapiens	116-125
25139490-8	2014	In conclusion, we postulate that vitamin D promotes cardiac differentiation through a negative modulation of the canonical WNT signaling pathway and by upregulating the expression of WNT11.	Vitamin D	33-42	Wnt family member 11	Homo sapiens	123-126
25139490-8	2014	In conclusion, we postulate that vitamin D promotes cardiac differentiation through a negative modulation of the canonical WNT signaling pathway and by upregulating the expression of WNT11.	Vitamin D	33-42	Wnt family member 11	Homo sapiens	183-188
25411034-3	2014	The metabolism of vitamin D is regulated by parathyroid hormone (PTH).	Vitamin D	18-27	parathyroid hormone	Homo sapiens	44-63
25240206-8	2014	We further explored vitamin D"s association with plasma IL-1beta, IL-6 and TNF-alpha.	Vitamin D	20-29	interleukin 1 beta	Homo sapiens	56-64
25394580-5	2014	Of the former, vitamin D metabolites, parathyroid hormone, and insulin-like growth factor-I indicate responses to variations in the supply of bone-related nutrients, such as vitamin D, Ca, inorganic phosphate and protein.	Vitamin D	174-183	insulin like growth factor 1	Homo sapiens	63-91
24722820-0	2014	Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation.	Vitamin D	0-9	gelsolin	Rattus norvegicus	129-137
24722820-4	2014	To identify additional factors that might limit vitamin D efficacy, we assessed the effects of vitamin D on plasma gelsolin (pGSN), a regulator of S1P that is downregulated in the CSF of MS patients.	Vitamin D	95-104	gelsolin	Rattus norvegicus	115-123
25240206-8	2014	We further explored vitamin D"s association with plasma IL-1beta, IL-6 and TNF-alpha.	Vitamin D	20-29	interleukin 6	Homo sapiens	66-70
25240206-8	2014	We further explored vitamin D"s association with plasma IL-1beta, IL-6 and TNF-alpha.	Vitamin D	20-29	tumor necrosis factor	Homo sapiens	75-84
25240206-12	2014	Low vitamin D levels were associated with higher levels of the inflammatory cytokines IL-6 and IL-1beta in the blood.	Vitamin D	4-13	interleukin 6	Homo sapiens	86-90
25240206-12	2014	Low vitamin D levels were associated with higher levels of the inflammatory cytokines IL-6 and IL-1beta in the blood.	Vitamin D	4-13	interleukin 1 beta	Homo sapiens	95-103
25489472-1	2014	Obese adolescents represent a particularly vulnerable group for vitamin D deficiency which appears to have negative consequences on insulin resistance and glucose homeostasis.	Vitamin D	64-73	insulin	Homo sapiens	132-139
25489472-3	2014	The biological mechanisms by which vitamin D influences glycemic control in obesity are not well understood, but are thought to involve enhancement of peripheral/hepatic uptake of glucose, attenuation of inflammation and/or regulation of insulin synthesis/secretion by pancreatic beta cells.	Vitamin D	35-44	insulin	Homo sapiens	238-245
25489472-8	2014	The few published clinical trials using vitamin D supplementation to improve insulin resistance and impaired glucose tolerance in obese adolescents have yielded beneficial effects.	Vitamin D	40-49	insulin	Homo sapiens	77-84
25489472-11	2014	These trials should also include clamp-derived measures of in vivo sensitivity and beta-cell function to more fully characterize the effects of vitamin D replenishment on insulin resistance.	Vitamin D	144-153	insulin	Homo sapiens	171-178
25622671-0	2014	[Effects of vitamin D supplementation on insulin resistance in patients with type 2 diabetes mellitus].	Vitamin D	12-21	insulin	Homo sapiens	41-48
25149065-0	2014	The vitamin D analog, MART-10, represses metastasis potential via downregulation of epithelial-mesenchymal transition in pancreatic cancer cells.	Vitamin D	4-13	septin 4	Homo sapiens	22-26
25149065-3	2014	Previously we have shown that vitamin D analog, MART-10 (19-nor-2alpha-(3-hydroxypropyl)-1alpha,25(OH)2D3), exerted potent antiproliferative effect on PDA in vitro and in vivo without causing hypercalcemia.	Vitamin D	30-39	septin 4	Homo sapiens	48-52
25622671-1	2014	OBJECTIVE: To explore the effects of oral vitamin D supplementation on anthropometric parameters and insulin resistance (IR) in type 2 diabetes mellitus (T2DM).	Vitamin D	42-51	insulin	Homo sapiens	101-108
25622671-12	2014	Thus vitamin D supplementation may reduce insulin resistance in T2DM.	Vitamin D	5-14	insulin	Homo sapiens	42-49
25375896-0	2014	The vitamin D analogue ED71 but Not 1,25(OH)2D3 targets HIF1alpha protein in osteoclasts.	Vitamin D	4-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-65
25093461-12	2014	Altogether, our results suggest that OC contributes with LH to 25-OH Vit D production by Leydig cells.	Vitamin D	69-74	bone gamma-carboxyglutamate protein	Homo sapiens	37-39
25413472-0	2014	Vitamin D regulating TGF-beta induced epithelial-mesenchymal transition.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	21-29
25413472-12	2014	However, the regulatory effect of vitamin D in epithelial-mesenchymal transition was more effective to TGF-beta1-induced changes.	Vitamin D	34-43	transforming growth factor beta 1	Homo sapiens	103-112
25144342-4	2014	In addition, vitamin D has been shown to have systemic effects on insulin resistance, dyslipidemia, and hypertension.	Vitamin D	13-22	insulin	Homo sapiens	66-73
25371233-0	2014	A novel pathogenic mutation of the CYP27B1 gene in a patient with vitamin D-dependent rickets type 1: a case report.	Vitamin D	66-75	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	35-42
25371233-3	2014	Vitamin D dependent rickets type 1 is inherited in an autosomal recessive pattern, and is caused by mutations in the CYP27B1 gene encoding the 1alpha-hydroxylase enzyme.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	117-124
25371233-4	2014	We report here a new mutation in CYP27B1, which lead to Vitamin D dependent rickets type 1.	Vitamin D	56-65	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	33-40
25371233-9	2014	CONCLUSION: The deleterious effect of this alteration, which was the only mutation detected in the CYP27B1 common gene of Vitamin D dependent rickets type 1 in the proband, and its autosomal recessive inheritance fashion, both support a pathogenic nature of this mutation as the cause of Vitamin D dependent rickets type 1.	Vitamin D	122-131	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	99-106
25371233-9	2014	CONCLUSION: The deleterious effect of this alteration, which was the only mutation detected in the CYP27B1 common gene of Vitamin D dependent rickets type 1 in the proband, and its autosomal recessive inheritance fashion, both support a pathogenic nature of this mutation as the cause of Vitamin D dependent rickets type 1.	Vitamin D	288-297	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	99-106
24688000-5	2014	Second, in 61 candidate SNPs involved in vitamin D metabolism and signaling, rs1507023 (in RBFOX1) and rs2296241 (in CYP24A1) showed significant associations with SBP, DBP, mean arterial pressure, or pulse pressure in the WGHS before, but not after, multiple testing corrections.	Vitamin D	41-50	RNA binding fox-1 homolog 1	Homo sapiens	91-97
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	tyrosinase related protein 1	Homo sapiens	281-286
25118085-0	2014	Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: a randomized, double-blind, placebo controlled trial.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	48-67
24875346-5	2014	On multiple-adjusted linear regression analyses, vitamin D deficiency/insufficiency with PTH in the highest tertile at 3 months independently predicted poorer beta-cell function (P = 0.03) and insulin sensitivity (P = 0.01) and increased fasting (P = 0.03) and 2-h glucose (P = 0.002) at 12 months postpartum.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	89-92
24875346-5	2014	On multiple-adjusted linear regression analyses, vitamin D deficiency/insufficiency with PTH in the highest tertile at 3 months independently predicted poorer beta-cell function (P = 0.03) and insulin sensitivity (P = 0.01) and increased fasting (P = 0.03) and 2-h glucose (P = 0.002) at 12 months postpartum.	Vitamin D	49-58	insulin	Homo sapiens	193-200
24875346-6	2014	In contrast, vitamin D deficiency/insufficiency with lower PTH did not predict these outcomes.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	59-62
24875346-7	2014	In conclusion, only vitamin D deficiency/insufficiency with increased PTH is an independent predictor of beta-cell dysfunction, insulin resistance, and glycemia, highlighting the need for consideration of the PTH/25-OH-D axis when studying the impact of vitamin D status on glucose homeostasis.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	70-73
24875346-7	2014	In conclusion, only vitamin D deficiency/insufficiency with increased PTH is an independent predictor of beta-cell dysfunction, insulin resistance, and glycemia, highlighting the need for consideration of the PTH/25-OH-D axis when studying the impact of vitamin D status on glucose homeostasis.	Vitamin D	20-29	insulin	Homo sapiens	128-135
24668555-4	2014	Vitamin D inhibits IFN-gamma and IL-17 production while inducing regulatory T cells.	Vitamin D	0-9	interferon gamma	Homo sapiens	19-28
25353014-0	2014	Association between Vitamin D and Adiponectin and Its Relationship with Body Mass Index: The META-Health Study.	Vitamin D	20-29	adiponectin, C1Q and collagen domain containing	Homo sapiens	34-45
25342586-0	2014	Does vitamin D deficiency inhibit anti-tumor necrosis factor therapy in patients with irritable bowel disease or does it simply result from more severe disease?	Vitamin D	5-14	tumor necrosis factor	Homo sapiens	39-60
25092061-9	2014	Vitamin level was negatively correlated with PTH and the correlation was more marked in subjects with vitamin D deficiency.	Vitamin D	102-111	parathyroid hormone	Homo sapiens	45-48
25498380-2	2014	However, in other situations, the initial increase in parathyroid hormone and bone remodeling may be slowed down excessively by a multitude of factors including age, ethnic origin, sex, and treatments such as vitamin D, calcium salts, calcimimetics, steroids, and so forth, leading to low bone turnover or adynamic bone disease.	Vitamin D	209-218	parathyroid hormone	Homo sapiens	54-73
25353014-2	2014	Previous studies have indicated that vitamin D levels are directly associated with adiponectin, and that this association varies across body mass index (BMI) categories; stronger with increasing BMI.	Vitamin D	37-46	adiponectin, C1Q and collagen domain containing	Homo sapiens	83-94
25353014-4	2014	METHODS: We assessed whether serum vitamin D is associated with serum adiponectin in a biracial population-based sample.	Vitamin D	35-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	70-81
25308347-10	2014	The fasting insulin levels were significantly higher in the group with GDM with a mean of 18.51 +- 6.44 compared to 8.95 +- 2.52 in the control group.The correlation coefficient (r) between HbA1c levels and Vitamin D level was -0.492 with a P value &lt;0.05.	Vitamin D	207-216	insulin	Homo sapiens	12-19
25308347-12	2014	Vitamin D levels correlated significantly with the fasting blood glucose, the fasting serum insulin and the HbA1c levels, the P value in all these correlations were &lt;0.05.	Vitamin D	0-9	insulin	Homo sapiens	92-99
25353014-13	2014	CONCLUSION: The association of vitamin D and adiponectin is dependent on race, gender, and BMI category.	Vitamin D	31-40	adiponectin, C1Q and collagen domain containing	Homo sapiens	45-56
25299668-11	2014	In a post hoc analysis restricted to participants with prediabetes, a significant beneficial effect of vitamin D and calcium supplementation on insulin sensitivity (HOMA%S and Matsuda) was observed.	Vitamin D	103-112	insulin	Homo sapiens	144-151
25299668-13	2014	However, in participants with prediabetes, supplementation with vitamin D and calcium may improve insulin sensitivity.	Vitamin D	64-73	insulin	Homo sapiens	98-105
25299668-1	2014	OBJECTIVES: To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, beta-cell function, inflammation and metabolic markers.	Vitamin D	40-49	insulin	Homo sapiens	87-94
26594646-11	2014	Genes involved with classical effects of vitamin D metabolism and excretion were activated, along with genes linked to autophagy such as G-protein coupled receptor 37 (GPR37) and Hypoxia-inducible factor 1-alpha (HIF1a).	Vitamin D	41-50	G protein-coupled receptor 37	Homo sapiens	137-166
26594646-11	2014	Genes involved with classical effects of vitamin D metabolism and excretion were activated, along with genes linked to autophagy such as G-protein coupled receptor 37 (GPR37) and Hypoxia-inducible factor 1-alpha (HIF1a).	Vitamin D	41-50	G protein-coupled receptor 37	Homo sapiens	168-173
26594646-11	2014	Genes involved with classical effects of vitamin D metabolism and excretion were activated, along with genes linked to autophagy such as G-protein coupled receptor 37 (GPR37) and Hypoxia-inducible factor 1-alpha (HIF1a).	Vitamin D	41-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	213-218
26594646-13	2014	CONCLUSIONS: This study shows that vitamin D reduces HCV protein production in cell culture synergistically with IFN-alpha.	Vitamin D	35-44	interferon alpha 1	Homo sapiens	113-122
26594646-14	2014	Vitamin D also activates gene expression independently and additively with IFN-alpha and this may explain its ability to aid in the clearance of HCV in vivo.	Vitamin D	0-9	interferon alpha 1	Homo sapiens	75-84
25150940-0	2014	Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	51-79
25279717-2	2014	We have demonstrated earlier that in vitro treatment of T cells from healthy individuals with TX527, a low-calcemic analog of bioactive vitamin D, can promote a CD4+ CD25high CD127low regulatory profile and imprint a migratory signature specific for homing to sites of inflammation.	Vitamin D	136-145	CD4 molecule	Homo sapiens	161-164
25279717-3	2014	Towards clinical application of vitamin D-induced Tregs in autologous adoptive immunotherapy for type 1 diabetes, we show here that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and TX527 similarly imprint T cells from type 1 diabetes patients with a CD4+ CD25high CD127low regulatory profile, modulate surface expression of skin- and inflammation-homing receptors, and increase expression of CTLA-4 and OX-40.	Vitamin D	32-41	CD4 molecule	Homo sapiens	244-247
24655660-1	2014	In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular.	Vitamin D	33-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113
25150940-3	2014	Since vitamin D is also implicated in vascular protection and affects IGF-1 biology, we hypothesized that it would influence the effect of IGF-1 on IMT.	Vitamin D	6-15	insulin like growth factor 1	Homo sapiens	70-75
25150940-3	2014	Since vitamin D is also implicated in vascular protection and affects IGF-1 biology, we hypothesized that it would influence the effect of IGF-1 on IMT.	Vitamin D	6-15	insulin like growth factor 1	Homo sapiens	139-144
25150940-9	2014	CONCLUSIONS: Circulating IGF-1 is vasoprotective primarily when vitamin D levels are low.	Vitamin D	64-73	insulin like growth factor 1	Homo sapiens	25-30
25173069-0	2014	Vitamin D puts the brakes on angiotensin II-induced oxidative stress and vascular smooth muscle cell senescence.	Vitamin D	0-9	angiotensinogen	Homo sapiens	29-43
24140234-2	2014	We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specific manner in adults aged &gt;=50 years, independent of other covariates and possible confounders, including body composition, blood tests, including serum parathyroid hormone (PTH) levels, dietary intake, and hormone replacement therapy in women.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	277-280
24961547-0	2014	Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients.	Vitamin D	0-9	insulin	Homo sapiens	82-89
25161115-11	2014	Nonadjusted analyses showed higher i-PTH concentration in vitamin D deficient patients (p &lt; 0.05).	Vitamin D	58-67	parathyroid hormone	Homo sapiens	37-40
25161115-14	2014	Vitamin D deficient patients also tended to have higher i-PTH levels.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	58-61
24878040-2	2014	OBJECTIVE: The objective of the study was to determine the combined effects of vitamin D deficiency and CKD on BMD in the elderly population and their relationships with sarcopenia and PTH levels.	Vitamin D	79-88	parathyroid hormone	Homo sapiens	185-188
25546928-8	2014	In women with abdominal obesity vitamin D correlated with luteinizing hormone/follicle-stimulating hormone ratio (LH/FSH) and SHBG.	Vitamin D	32-41	sex hormone binding globulin	Homo sapiens	126-130
25517270-12	2014	CONCLUSION: In our study, vitamin D deficiency was more prevalent in patients with SLE and was associated with higher levels of IL-6 and hematuria.	Vitamin D	26-35	interleukin 6	Homo sapiens	128-132
24878040-8	2014	Multivariable logistic regression analyses demonstrated that CKD subjects with vitamin D deficiency showed a significantly increased risk of osteoporosis or osteopenia [odds ratios 1.49 and 2.06 (1.81 and 2.65) at the femur neck and total hip, respectively, in women (men)], which was mainly associated with elevated levels of PTH and sarcopenia in these groups.	Vitamin D	79-88	parathyroid hormone	Homo sapiens	327-330
24176765-12	2014	In summary, CYP11A1 initiates new pathways of vitamin D metabolism in a range of tissues and products could have important physiological roles at the local or systemic level.	Vitamin D	46-55	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	12-19
24095930-11	2014	Levels of "free" 25OHD are dependent on the concentration of DBP and alternative serum binding proteins such as albumin, but will also be influenced by variations in DBP binding affinity for specific vitamin D metabolites.	Vitamin D	200-209	D-box binding PAR bZIP transcription factor	Homo sapiens	166-169
24120915-6	2014	Treatment with TNFalpha and IL-6 led to decreased expression of the vitamin D activating enzyme CYP27B1.	Vitamin D	68-77	tumor necrosis factor	Homo sapiens	15-23
24120915-6	2014	Treatment with TNFalpha and IL-6 led to decreased expression of the vitamin D activating enzyme CYP27B1.	Vitamin D	68-77	interleukin 6	Homo sapiens	28-32
24184871-5	2014	Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1).	Vitamin D	41-50	fibronectin 1	Homo sapiens	107-118
24120915-6	2014	Treatment with TNFalpha and IL-6 led to decreased expression of the vitamin D activating enzyme CYP27B1.	Vitamin D	68-77	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	96-103
24128439-2	2014	We examined whether DNA methylation levels of Cytochrome P450 (CYP) enzymes (CYP2R1, CYP24A1, CYP27A1, and CYP27B1) are potential biomarkers predicting vitamin D response variation.	Vitamin D	152-161	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-61
24128439-2	2014	We examined whether DNA methylation levels of Cytochrome P450 (CYP) enzymes (CYP2R1, CYP24A1, CYP27A1, and CYP27B1) are potential biomarkers predicting vitamin D response variation.	Vitamin D	152-161	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66
24128439-2	2014	We examined whether DNA methylation levels of Cytochrome P450 (CYP) enzymes (CYP2R1, CYP24A1, CYP27A1, and CYP27B1) are potential biomarkers predicting vitamin D response variation.	Vitamin D	152-161	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	107-114
24176760-3	2014	The CaSR promoter harbors vitamin D elements responsive to 1,25-dihydroxyvitamin D3 (1,25D3) and NF-kappaB, STAT, and SP1 binding sites accounting for responsiveness to proinflammatory cytokines.	Vitamin D	26-35	calcium sensing receptor	Homo sapiens	4-8
24176765-0	2014	The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.	Vitamin D	41-50	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	12-19
24361583-2	2014	During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively.	Vitamin D	55-64	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	130-137
24239508-11	2014	These genes possess vitamin D response elements (VDRE) adjacent to TCF/beta-catenin response elements and are regulated by both VDR and beta-catenin signaling.	Vitamin D	20-29	hepatocyte nuclear factor 4 alpha	Homo sapiens	67-70
25089537-9	2014	However, stimulated intracellular LL-37 expression (ratio of stimulated:unstimulated MDM) was significantly reduced in the vitamin D group v. placebo (P=0 02).	Vitamin D	123-132	cathelicidin antimicrobial peptide	Homo sapiens	34-39
25662524-6	2014	Older age, African-American race, winter/spring season, higher insulin level, total number of comorbidities, and polycystic ovary syndrome (in girls) were significantly associated with vitamin D deficiency.	Vitamin D	185-194	insulin	Homo sapiens	63-70
25230725-3	2014	Although it has been reported that activated T cells express the 25(OH)D-1alpha-hydroxylase CYP27B1 that converts 25(OH)D3 to 1,25(OH)2D3, it is still controversial whether activated T cells have the capacity to produce sufficient amounts of 1,25(OH)2D3 to affect vitamin D-responsive genes.	Vitamin D	264-273	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	92-99
25230725-5	2014	RESULTS: We found that activated T cells express CYP27B1 and have the capacity to produce sufficient 1,25(OH)2D3 to affect vitamin D-responsive genes when cultured with physiological concentrations of 25(OH)D3 in serum-free medium.	Vitamin D	123-132	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	49-56
25230725-9	2014	CONCLUSIONS: Activated T cells express CYP27B1 and can convert 25(OH)D3 to 1,25(OH)2D3 in sufficiently high concentrations to affect vitamin D-responsive genes when cultured in serum-free medium.	Vitamin D	133-142	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	39-46
25356106-5	2014	It is also reported that vitamin D (Vit.	Vitamin D	25-34	vitrin	Homo sapiens	36-39
29159108-0	2015	Insulin resistance in Saudi postmenopausal women with and without metabolic syndrome and its association with vitamin D deficiency.	Vitamin D	110-119	insulin	Homo sapiens	0-7
25156130-0	2014	Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients.	Vitamin D	63-72	apelin	Homo sapiens	45-51
24973411-4	2014	Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	43-46
24973411-4	2014	Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis.	Vitamin D	113-122	parathyroid hormone	Homo sapiens	43-46
25593737-0	2014	Effect of therapeutic dose of vitamin d on serum adiponectin and glycemia in vitamin d-insufficient or deficient type 2 diabetic patients.	Vitamin D	30-39	adiponectin, C1Q and collagen domain containing	Homo sapiens	49-60
25593737-3	2014	Vitamin D may involve in regulation of the adiponectin levels, which is directly related to insulin sensitivity.	Vitamin D	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
25593737-3	2014	Vitamin D may involve in regulation of the adiponectin levels, which is directly related to insulin sensitivity.	Vitamin D	0-9	insulin	Homo sapiens	92-99
25593737-4	2014	OBJECTIVES: The aim of this study was to investigate the effect of therapeutic dose of vitamin D on serum adiponectin and insulin resistance in vitamin D-insufficient or deficient type 2 diabetic patients.	Vitamin D	87-96	adiponectin, C1Q and collagen domain containing	Homo sapiens	106-117
25593737-4	2014	OBJECTIVES: The aim of this study was to investigate the effect of therapeutic dose of vitamin D on serum adiponectin and insulin resistance in vitamin D-insufficient or deficient type 2 diabetic patients.	Vitamin D	87-96	insulin	Homo sapiens	122-129
25593737-4	2014	OBJECTIVES: The aim of this study was to investigate the effect of therapeutic dose of vitamin D on serum adiponectin and insulin resistance in vitamin D-insufficient or deficient type 2 diabetic patients.	Vitamin D	144-153	insulin	Homo sapiens	122-129
25156130-5	2014	We postulated that deficiency in Vitamin D levels might be associated with higher MPV and lower serum apelin levels leading a further increase in insulin resistance in diabetic patients.	Vitamin D	33-42	apelin	Homo sapiens	102-108
25156130-5	2014	We postulated that deficiency in Vitamin D levels might be associated with higher MPV and lower serum apelin levels leading a further increase in insulin resistance in diabetic patients.	Vitamin D	33-42	insulin	Homo sapiens	146-153
24272594-9	2014	The risk of having a high level of ALT, AST, or GGT tended to be higher for lower vitamin D levels, although not statistically significant.	Vitamin D	82-91	solute carrier family 17 member 5	Homo sapiens	40-43
24989998-3	2014	In this issue of Diabetologia (DOI: 10.1007/s00125-014-3293-x ), Asemi and colleagues report that co-supplementation of vitamin D and calcium among women with diet-controlled GDM improves several biomarkers of metabolic status, including insulin, glucose and cholesterol.	Vitamin D	120-129	insulin	Homo sapiens	238-245
24926821-3	2014	The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form.	Vitamin D	38-47	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	140-179
25194407-0	2014	Relationship between vitamin D receptor gene FokI and ApaI polymorphisms and serum levels of fetuin-A, vitamin D, and parathyroid hormone in patients on hemodialysis.	Vitamin D	21-30	alpha 2-HS glycoprotein	Homo sapiens	93-101
24949660-9	2014	Primary myotubes also expressed functional CYP27B1 as demonstrated by luciferase reporter studies, supporting an autoregulatory vitamin D-endocrine system in muscle.	Vitamin D	128-137	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	43-50
24673126-3	2014	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], has been shown to increase the frequency of Foxp3(+) CD4(+) T regulatory (Treg) cells when present at high concentrations or under strong T-cell stimulation in culture.	Vitamin D	19-28	CD4 molecule	Homo sapiens	128-131
25317290-0	2014	The Effect of Vitamin D Supplementation on Adiposity, Blood Glycated Hemoglobin, Serum Leptin and Tumor Necrosis Factor-alpha in Type 2 Diabetic Patients.	Vitamin D	14-23	tumor necrosis factor	Homo sapiens	98-125
25194407-0	2014	Relationship between vitamin D receptor gene FokI and ApaI polymorphisms and serum levels of fetuin-A, vitamin D, and parathyroid hormone in patients on hemodialysis.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	118-137
25194407-2	2014	The aim of present study was to evaluate the relationship between vitamin D receptor (VDR) gene FokI and ApaI polymorphisms with serum levels of fetuin-A, vitamin D, and intact PTH in hemodialysis patients.	Vitamin D	66-75	alpha 2-HS glycoprotein	Homo sapiens	145-153
23881908-7	2014	We compared the HIV plasma RNA, absolute CD4 counts, and CD4% in pre- and post-vitamin D supplementation.	Vitamin D	79-88	CD4 molecule	Homo sapiens	57-60
25566461-0	2014	Effects of vitamin D supplementation and circuit training on indices of obesity and insulin resistance in T2D and vitamin D deficient elderly women.	Vitamin D	11-20	insulin	Homo sapiens	84-91
24630484-7	2014	The expression of MMP-9, MMP-2, and MMP-3 decreases in the presence of vitamin D derivatives in UC and CD with the exception of 1,25(OH)2D3 that does not affect the levels of MMP-9 and MMP-2 in CD.	Vitamin D	71-80	matrix metallopeptidase 3	Homo sapiens	36-41
23881908-12	2014	Absolute CD4 counts averaged lower in patients who have severe vitamin D deficiency (25-(OH)D &lt;=10 ng/mL; mean 574.41 +- 306.17 cells/mm(3)) compared to those who had higher vitamin D level (mean 701.15 +- 444.19 cells/mm(3)).	Vitamin D	63-72	CD4 molecule	Homo sapiens	9-12
23881908-13	2014	The CD4% were also lower (mean 25.12% +- 12.5%) in those who have severe vitamin D deficiency compared to those whose vitamin D level was &gt;=11 ng/mL (mean 29.47% +- 11.62%).	Vitamin D	73-82	CD4 molecule	Homo sapiens	4-7
25228838-0	2014	The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes.	Vitamin D	24-33	insulin	Homo sapiens	53-60
25228838-1	2014	BACKGROUND/AIMS: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease.	Vitamin D	97-106	insulin	Homo sapiens	135-142
25606437-2	2014	Some of the immune non-classical actions of vitamin D may point to its role in the pathogenesis of type 2 DM through down-regulation of cytokines (IL-6).	Vitamin D	44-53	interleukin 6	Homo sapiens	147-151
25158250-3	2014	Real-time polymerase chain reaction was used to determine the effect of vitamin D on intracellular expression of mRNA of the multidrug-resistant gene (MDRI) and the multidrug-resistance-related gene (MRP1).	Vitamin D	72-81	ATP binding cassette subfamily C member 1	Homo sapiens	200-204
25158250-5	2014	After treatment of Jurkat/ADR and K562/ADR cells with vitamin D, multidrug resistance was reversed in a dose-dependent manner, which may have reduced mRNA expression of the MDR1 and MRP1 genes, the P-glycoprotein content on the cell surface, and the intracellular glutathione level.	Vitamin D	54-63	ATP binding cassette subfamily B member 1	Homo sapiens	173-177
25158250-5	2014	After treatment of Jurkat/ADR and K562/ADR cells with vitamin D, multidrug resistance was reversed in a dose-dependent manner, which may have reduced mRNA expression of the MDR1 and MRP1 genes, the P-glycoprotein content on the cell surface, and the intracellular glutathione level.	Vitamin D	54-63	ATP binding cassette subfamily C member 1	Homo sapiens	182-186
25111832-0	2014	Vitamin D status among Thai school children and the association with 1,25-Dihydroxyvitamin D and parathyroid hormone levels.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	97-116
25044176-4	2014	We investigated the effects of improving vitamin D status on insulin sensitivity, insulin secretion, and inflammatory markers in patients with type 2 diabetes.	Vitamin D	41-50	insulin	Homo sapiens	61-68
24938764-7	2014	Evaluation at an early time point (1 week postinfection) showed that animals fed high vitamin D had decreased MAPK (p-P38 and p-JNK) activation in lamina propria leukocytes as well as decreased NFkappaB activation in colonic epithelial cells.	Vitamin D	86-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	194-202
25606437-3	2014	Although there is evidence to support a relationship among vitamin D status, chronic inflammation and insulin resistance, the underlying mechanism requires further exploration.	Vitamin D	59-68	insulin	Homo sapiens	102-109
25088927-3	2014	Thioredoxin-interacting protein (TXNIP), also known as vitamin D-upregulated protein or thioredoxin-binding-protein-2, functions as a physiological inhibitor of Trx, and pathological suppression of Trx by TXNIP has been demonstrated in diabetes and cardiovascular diseases.	Vitamin D	55-64	thioredoxin interacting protein	Homo sapiens	0-31
24703961-17	2014	CONCLUSIONS: Lower eGFR is associated strongly with reduced vitamin D catabolism, as measured by circulating 24,25(OH)2D3 concentration.	Vitamin D	60-69	epidermal growth factor receptor	Homo sapiens	19-23
25088927-3	2014	Thioredoxin-interacting protein (TXNIP), also known as vitamin D-upregulated protein or thioredoxin-binding-protein-2, functions as a physiological inhibitor of Trx, and pathological suppression of Trx by TXNIP has been demonstrated in diabetes and cardiovascular diseases.	Vitamin D	55-64	thioredoxin interacting protein	Homo sapiens	33-38
25088927-3	2014	Thioredoxin-interacting protein (TXNIP), also known as vitamin D-upregulated protein or thioredoxin-binding-protein-2, functions as a physiological inhibitor of Trx, and pathological suppression of Trx by TXNIP has been demonstrated in diabetes and cardiovascular diseases.	Vitamin D	55-64	thioredoxin interacting protein	Homo sapiens	88-117
25088927-3	2014	Thioredoxin-interacting protein (TXNIP), also known as vitamin D-upregulated protein or thioredoxin-binding-protein-2, functions as a physiological inhibitor of Trx, and pathological suppression of Trx by TXNIP has been demonstrated in diabetes and cardiovascular diseases.	Vitamin D	55-64	thioredoxin interacting protein	Homo sapiens	205-210
25489444-0	2014	Effect of Vitamin D Supplementation on C-reactive Protein in Patients with Nonalcoholic Fatty Liver.	Vitamin D	10-19	C-reactive protein	Homo sapiens	39-57
24924628-5	2014	1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells.	Vitamin D	19-28	osteoglycin	Mus musculus	129-132
24854954-8	2014	In primary human peripheral blood mononuclear cells from 71 prediabetic subjects of a vitamin D(3) intervention study (VitDmet) CD97, LRRC8A, SLC37A2 and NRIP1 can be used as transcriptomic biomarkers for classifying human individuals for their possible benefit from vitamin D(3) supplementation.	Vitamin D	86-95	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	134-140
24429404-0	2014	The impact of vitamin D status on the relative increase in fibroblast growth factor 23 and parathyroid hormone in chronic kidney disease.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	91-110
25072652-1	2014	PURPOSE: Vitamin D deficiency is a common condition that is associated with diabetes and insulin resistance.	Vitamin D	9-18	insulin	Homo sapiens	89-96
25072652-2	2014	However, the association between vitamin D and insulin resistance has not been fully studied, especially in the general adolescent population.	Vitamin D	33-42	insulin	Homo sapiens	47-54
24854576-2	2014	Publications on the health effects of vitamin D (25(OH) D) had almost triplicate in the last 10years, not only for its known "calcemic effects" (calcium, phosphor, PTH), but for the more recent findings on its "non-calcemic effects" (all-cause and cardiovascular mortality, and relation with certain types of cancer).	Vitamin D	38-47	parathyroid hormone	Homo sapiens	164-167
24854576-4	2014	The literature also deals with seasonal variations of vitamin D, showing levels that rise in summer and fall in winter and with DBP phenotypes and geographical location that affect seasonality of 25(OH) D measurements.	Vitamin D	54-63	D-box binding PAR bZIP transcription factor	Homo sapiens	128-131
24924628-10	2014	In conclusion, these findings showed for the first time that active vitamin D plays important roles in myogenesis and muscle-induced osteoblastogenesis through OGN expression.	Vitamin D	68-77	osteoglycin	Mus musculus	160-163
24924628-11	2014	Active vitamin D treatment may rescue the AGEs-induced sarcopenia as well as - suppressed osteoblastic differentiation via OGN expression in myoblasts.	Vitamin D	7-16	osteoglycin	Mus musculus	123-126
24768180-3	2014	To assess for association between polymorphisms of vitamin-D pathway genes CYP27B1, vitamin-D binding protein (VDBP) and VDR with HIV-1 infection, disease progression to acquired immunodeficiency syndrome (AIDS) was analysed according to CDC93 criteria in a cohort of 185 HIV-1 seroprevalent patients belonging to the injection drug users.	Vitamin D	51-60	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	75-82
25033925-1	2014	BACKGROUND: Besides the classical role of vitamin D on calcium and bone homeostasis, vitamin D deficiency has recently been identified as a contributing factor in the onset of insulin resistance in type 2 diabetes mellitus.	Vitamin D	85-94	insulin	Homo sapiens	176-183
25033925-10	2014	Our findings will contribute to the knowledge of the relationship between vitamin D status and insulin resistance in patients with type 2 diabetes mellitus.	Vitamin D	74-83	insulin	Homo sapiens	95-102
25000408-13	2014	The association of 25OHD with BMI, high triglyceride concentration and apolipoprotein B/apolipoprotein A1 ratio may be related to the role of vitamin D in inflammation, but more detailed studies are needed.	Vitamin D	142-151	apolipoprotein B	Homo sapiens	71-87
25045275-0	2014	Relationship between insulin resistance and plasma vitamin D in adults.	Vitamin D	51-60	insulin	Homo sapiens	21-28
25000408-13	2014	The association of 25OHD with BMI, high triglyceride concentration and apolipoprotein B/apolipoprotein A1 ratio may be related to the role of vitamin D in inflammation, but more detailed studies are needed.	Vitamin D	142-151	apolipoprotein A1	Homo sapiens	88-105
25045275-1	2014	A recent relationship between vitamin D deficiency and the risk of type 2 diabetes mellitus (T2DM) and insulin resistance has been established through several studies.	Vitamin D	30-39	insulin	Homo sapiens	103-110
24798231-11	2014	These findings suggest that HIV and/or HIV-related variables may alter the expected positive relationship between vitamin D and LL-37 and should be further investigated.	Vitamin D	114-123	cathelicidin antimicrobial peptide	Homo sapiens	128-133
25045275-3	2014	The aim of this study was to investigate the relationship between the plasma vitamin D levels (25[OH]D) and the factors linked to insulin resistance in a representative sample of Canadians ranging in age from 16-79 years.	Vitamin D	77-86	insulin	Homo sapiens	130-137
25045275-6	2014	An inverse relationship between insulin resistance and plasma vitamin D level in both men and women was observed.	Vitamin D	62-71	insulin	Homo sapiens	32-39
25045275-8	2014	If causally associated, the supplementation of vitamin D may help in preventing insulin resistance and subsequent T2DM.	Vitamin D	47-56	insulin	Homo sapiens	80-87
24898240-0	2014	Effect of moderate-dose vitamin D supplementation on insulin sensitivity in vitamin D-deficient non-Western immigrants in the Netherlands: a randomized placebo-controlled trial.	Vitamin D	24-33	insulin	Homo sapiens	53-60
24798231-0	2014	LL-37 concentrations and the relationship to vitamin D, immune status, and inflammation in HIV-infected children and young adults.	Vitamin D	45-54	cathelicidin antimicrobial peptide	Homo sapiens	0-5
24798231-1	2014	Antimicrobial peptide LL-37 is produced in response to active vitamin D to exert immunomodulatory effects and inhibits HIV replication in vitro.	Vitamin D	62-71	cathelicidin antimicrobial peptide	Homo sapiens	22-27
24898240-0	2014	Effect of moderate-dose vitamin D supplementation on insulin sensitivity in vitamin D-deficient non-Western immigrants in the Netherlands: a randomized placebo-controlled trial.	Vitamin D	76-85	insulin	Homo sapiens	53-60
24898240-2	2014	Because many non-Western immigrants in the Netherlands are vitamin D deficient, obese, and at high risk of diabetes, vitamin D supplementation may contribute to prevent diabetes and insulin resistance.	Vitamin D	117-126	insulin	Homo sapiens	182-189
24898240-3	2014	OBJECTIVE: We examined the effect of vitamin D supplementation on insulin sensitivity and beta cell function in overweight, vitamin D-deficient, non-Western immigrants at high risk of diabetes.	Vitamin D	37-46	insulin	Homo sapiens	66-73
24742123-9	2014	RESULTS: In linear regression analysis adjusting for age, body mass index, homeostatic model assessment of insulin resistance, and lipid profile, serum vitamin D level positively correlated with total T (P &lt; .001) and free androgen index (P &lt; .001) but did not correlate with dehydroepiandrosterone sulfate or other steroid hormones.	Vitamin D	152-161	insulin	Homo sapiens	107-114
25119802-1	2014	Vitamin D (Vit.D) and parathormone (PTH) measurements are usually prescribed for phosphocalcic metabolism assessment and, especially for Vit.D, more and more frequently for other pathologies.	Vitamin D	0-9	vitrin	Homo sapiens	11-14
24748579-2	2014	However, recent studies suggest that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D.	Vitamin D	42-51	D-box binding PAR bZIP transcription factor	Homo sapiens	153-156
24748579-2	2014	However, recent studies suggest that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D.	Vitamin D	240-249	D-box binding PAR bZIP transcription factor	Homo sapiens	153-156
24726754-12	2014	The TNFalpha-rich microenvironment of this tissue promotes inflammation; these effects are reversed by vitamin D in vitro.	Vitamin D	103-112	tumor necrosis factor	Homo sapiens	4-12
24712573-2	2014	Vitamin D-binding protein (DBP) levels vary with race and may modulate "bioavailable" levels of 25(OH)D. OBJECTIVE: To determine the effect of DBP levels on the functional response to vitamin D.	Vitamin D	184-193	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
24712573-2	2014	Vitamin D-binding protein (DBP) levels vary with race and may modulate "bioavailable" levels of 25(OH)D. OBJECTIVE: To determine the effect of DBP levels on the functional response to vitamin D.	Vitamin D	184-193	D-box binding PAR bZIP transcription factor	Homo sapiens	143-146
22708508-9	2014	Serum PTH levels were significantly higher in severely vit D deficient than sufficient infants.	Vitamin D	55-60	parathyroid hormone	Homo sapiens	6-9
24821067-0	2014	Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy.	Vitamin D	29-38	cathelicidin antimicrobial peptide	Homo sapiens	7-12
24821067-1	2014	Low levels of the vitamin D-regulated antimicrobial peptide cathelicidin (LL-37) may negatively impact the immune status of human immunodeficiency virus-1 (HIV-1) infected individuals (HIV+).	Vitamin D	18-27	cathelicidin antimicrobial peptide	Homo sapiens	74-79
24821067-2	2014	We compared plasma LL-37 levels in healthy controls (HIV-) and HIV+ individuals on or off antiretroviral therapies (ARTs) (ART+ and ART-, respectively), and evaluated the relationship between vitamin D and LL-37 levels.	Vitamin D	192-201	cathelicidin antimicrobial peptide	Homo sapiens	19-24
24747771-8	2014	This manuscript reports novel findings regarding the effects of 1alpha,25-dihydroxyvitamin D3 on NFkappaB signaling in tamoxifen-resistant breast cancer cells and suggests that vitamin D might be interesting for further evaluation as a new strategy to treat antiestrogen-resistant breast cancers.	Vitamin D	83-92	nuclear factor kappa B subunit 1	Homo sapiens	97-105
25627231-6	2014	Four of 7 studies found a significant negative correlation between vitamin D levels and Bath Ankylosing Spondylitis Index (BASDAI), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).	Vitamin D	67-76	C-reactive protein	Homo sapiens	173-191
25627231-6	2014	Four of 7 studies found a significant negative correlation between vitamin D levels and Bath Ankylosing Spondylitis Index (BASDAI), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).	Vitamin D	67-76	C-reactive protein	Homo sapiens	193-196
24961717-6	2014	RESULTS: Controlling for age and total caloric intake, higher intake of vitamin B12, vitamin D and omega-3 polyunsaturated fatty acid (PUFA) was associated with lower Abeta load in AD regions on PiB-PET, while higher intake of beta-carotene and folate was associated with higher glucose metabolism on FDG-PET.	Vitamin D	85-94	amyloid beta precursor protein	Homo sapiens	167-172
24918698-1	2014	Vitamin D might elicit protective effects against cardiovascular disease by decreasing the level of circulating high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker.	Vitamin D	0-9	C-reactive protein	Homo sapiens	152-155
24821973-1	2014	Recent clinical research suggests a role for vitamin D in the response to IFN-alpha-based therapy of chronic hepatitis C. Therefore, we aimed to explore the underlying mechanisms in vitro.	Vitamin D	45-54	interferon alpha 1	Homo sapiens	74-83
25191532-2	2014	We hypothesized that vitamin D supplementation would ameliorate liver fibrosis in ATP-binding cassette transporter B4 knockout (Abcb4 (-/-)) mice as a preclinical model of sclerosing cholangitis.	Vitamin D	21-30	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	128-133
25191532-7	2014	RESULTS: Different vitamin D concentrations were observed depending on genotype and diet group, with Abcb4 (-/-) mice on the control diet showing lower vitamin D concentrations compared to wild-type mice.	Vitamin D	152-161	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	101-106
25191532-8	2014	Abcb4 (-/-) animals on the low vitamin D diet demonstrated the most advanced liver fibrosis and highest hepatic collagen contents.	Vitamin D	31-40	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-5
25191532-9	2014	Feeding Abcb4 (-/-) mice a high vitamin D diet enriched serum vitamin D levels, lowered liver enzyme activities, altered expression levels of profibrogenic genes and ameliorated, in part, liver injury.	Vitamin D	32-41	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	8-13
25191532-9	2014	Feeding Abcb4 (-/-) mice a high vitamin D diet enriched serum vitamin D levels, lowered liver enzyme activities, altered expression levels of profibrogenic genes and ameliorated, in part, liver injury.	Vitamin D	62-71	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	8-13
25191532-10	2014	CONCLUSIONS: This is the first report to demonstrate that fibrogenesis in the established Abcb4 (-/-) model is influenced by vitamin D supplementation.	Vitamin D	125-134	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	90-95
24926881-11	2014	Up-regulation of TLR2, TLR4 and dectin-1was observed in the lungs and AMs from vitamin D deficient mice both at baseline and after A. fumigatus exposure.	Vitamin D	79-88	toll-like receptor 4	Mus musculus	23-27
24918698-2	2014	Thus, we conducted a meta-analysis of randomized controlled trials to evaluate the association of vitamin D supplementation with circulating hs-CRP level.	Vitamin D	98-107	C-reactive protein	Homo sapiens	144-147
24918698-5	2014	The results of the meta-analysis of 10 trials involving a total of 924 participants showed that vitamin D supplementation significantly decreased the circulating hs-CRP level by 1.08 mg/L (95% CI, -2.13, -0.03), with the evidence of heterogeneity.	Vitamin D	96-105	C-reactive protein	Homo sapiens	165-168
24918698-8	2014	In summary, vitamin D supplementation is beneficial for the reduction of circulating hs-CRP.	Vitamin D	12-21	C-reactive protein	Homo sapiens	88-91
24895985-1	2014	PURPOSE: In the context of osteoimmunology in Crohn"s disease, an association was hypothesized among vitamin D and members of the TNF-alpha family, known as the RANK (receptor-activator of nuclear factor- kappaB)-RANK ligand-osteoprotegerin pathway.	Vitamin D	101-110	tumor necrosis factor	Homo sapiens	130-139
24740207-2	2014	Vitamin D-binding protein (DBP) is the primary carrier of vitamin D in the circulation and regulates the bioavailability of 25-hydroxyvitamin D.	Vitamin D	58-67	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
24740207-3	2014	Epidemiologic studies have shown direct DBP-risk relations and modification by DBP of vitamin D-disease associations.	Vitamin D	86-95	D-box binding PAR bZIP transcription factor	Homo sapiens	79-82
24740207-10	2014	Understanding the genetic contributions to circulating DBP may provide greater insights into the vitamin D binding, transport, and other functions of DBP and the effect of vitamin D status on health outcomes.	Vitamin D	97-106	D-box binding PAR bZIP transcription factor	Homo sapiens	55-58
24740207-10	2014	Understanding the genetic contributions to circulating DBP may provide greater insights into the vitamin D binding, transport, and other functions of DBP and the effect of vitamin D status on health outcomes.	Vitamin D	172-181	D-box binding PAR bZIP transcription factor	Homo sapiens	55-58
24887145-10	2014	Effects of VDR or VEGF blockade were partially prevented by vitamin D.	Vitamin D	60-69	vascular endothelial growth factor A	Homo sapiens	18-22
25077091-0	2014	Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	93-112
25077091-1	2014	PURPOSE: This study was performed to investigate the relationship between serum vitamin D and parathyroid hormone (PTH) levels as well as to describe the prevalence and the risk factors of vitamin D deficiency (VDD) in Korean children.	Vitamin D	80-89	parathyroid hormone	Homo sapiens	94-113
24382124-8	2014	CONCLUSION: Vitamin D replacement in subjects with PHPT and coexistent vitamin D deficiency increase 25 (OH) D and reduce serum PTH significantly without causing hypercalcaemia and hypercalciuria.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	128-131
24382124-8	2014	CONCLUSION: Vitamin D replacement in subjects with PHPT and coexistent vitamin D deficiency increase 25 (OH) D and reduce serum PTH significantly without causing hypercalcaemia and hypercalciuria.	Vitamin D	71-80	parathyroid hormone	Homo sapiens	128-131
24636395-1	2014	OBJECTIVE: To determine the effects of high-dose vitamin D on insulin sensitivity in polycystic ovary syndrome (PCOS).	Vitamin D	49-58	insulin	Homo sapiens	62-69
24643654-0	2014	Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells.	Vitamin D	84-93	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	14-21
24643654-3	2014	Cell-autonomous control of vitamin D activity can be modulated by the action of the vitamin D-activating and -inactivating hydroxylases, CYP27B1, and CYP24A1, respectively.	Vitamin D	27-36	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	137-144
25505940-5	2014	METHOD: In a double blind randomized placebo controlled study we evaluated the effect of a monthly dose of 100,000IU of vitamin D3 for three months on the level of serum 25(OH)D, intact parathyroid hormone (PTH), urinary isoprostane, adipocyte cytokine expression and arterial stiffness among 130 overweight and obese (BMI &gt; 25) African Americans with elevated blood pressure (130 - 150/85 - 100 mmHg) and low serum vitamin D level (10 - 25 ng/ml).	Vitamin D	120-129	parathyroid hormone	Homo sapiens	186-205
24326945-1	2014	Vitamin D (VD) was studied for its anti-inflammatory activities with prepared VD-loaded nanoemulsions (VDNM) in ovalbumin-induced asthmatic mice in this paper.	Vitamin D	0-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	112-121
25109735-0	2014	Does serum vitamin-D predict insulin resistance in individuals with prediabetes?	Vitamin D	11-20	insulin	Homo sapiens	29-36
25109736-0	2014	Insulin resistance &amp; vitamin-D levels in prediabetics.	Vitamin D	25-34	insulin	Homo sapiens	0-7
24686054-3	2014	The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing, and immune response of murine microglial cultures after stimulation with the Toll-like receptor (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), poly(I C) (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9).	Vitamin D	65-74	toll-like receptor 12	Mus musculus	280-286
24214881-5	2014	The strong protective association observed between higher circulating DBP concentration and kidney cancer risk requires replication but suggests a vitamin D-independent influence of DBP.	Vitamin D	147-156	D-box binding PAR bZIP transcription factor	Homo sapiens	70-73
24686054-3	2014	The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing, and immune response of murine microglial cultures after stimulation with the Toll-like receptor (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), poly(I C) (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9).	Vitamin D	65-74	toll-like receptor 4	Mus musculus	327-331
24899811-3	2014	An increased prevalence of neurologic and psychiatric diseases involving dopaminergic dysfunction in vitamin D-deficient patients led us to hypothesize that vitamin D deficiency might result in dopaminergic dysfunction and consequently, the development of RLS (in which dopaminergic dysfunction plays a pivotal role).	Vitamin D	101-110	RLS1	Homo sapiens	256-259
24617709-3	2014	OBJECTIVE: The objective of the study was to assess short-term changes in vitamin D-related mineral metabolism in CD after anti-TNF-alpha induction therapy.	Vitamin D	74-83	tumor necrosis factor	Homo sapiens	128-137
25197306-0	2014	Effect of vitamin D on insulin resistance and nephropathy in type 2 diabetes.	Vitamin D	10-19	insulin	Homo sapiens	23-30
24352479-2	2014	Some researchers have suggested that the serum vitamin D (Vit D) level may relate to disease activity.	Vitamin D	47-56	vitrin	Homo sapiens	58-61
24517148-0	2014	A homozygous CaSR mutation causing a FHH phenotype completely masked by vitamin D deficiency presenting as rickets.	Vitamin D	72-81	calcium sensing receptor	Homo sapiens	13-17
24517148-7	2014	Vitamin D treatment unmasked features resembling FHH, and genetic testing revealed a homozygous CaSRQ459R mutation.	Vitamin D	0-9	calcium sensing receptor	Homo sapiens	49-52
24517148-9	2014	The CaSRQ459R mutation leads to mild functional inactivation in vitro, which explains the FHH-like phenotype in homozygous family members and the grossly exaggerated PTH response to vitamin D deficiency in the index case.	Vitamin D	182-191	parathyroid hormone	Homo sapiens	166-169
25160855-7	2014	Taking the present data together with previous findings, we suggest a possible link between gastric PTHLH and vitamin D and bone metabolism.	Vitamin D	110-119	parathyroid hormone-like peptide	Mus musculus	100-105
24899811-3	2014	An increased prevalence of neurologic and psychiatric diseases involving dopaminergic dysfunction in vitamin D-deficient patients led us to hypothesize that vitamin D deficiency might result in dopaminergic dysfunction and consequently, the development of RLS (in which dopaminergic dysfunction plays a pivotal role).	Vitamin D	157-166	RLS1	Homo sapiens	256-259
24899811-4	2014	Thus, the aim of this study was to evaluate the relationship between vitamin D deficiency and RLS.	Vitamin D	69-78	RLS1	Homo sapiens	94-97
24899811-9	2014	The presence of RLS was significantly higher in the vitamin D deficiency group (chi (2)=12.87, P&lt;0.001).	Vitamin D	52-61	RLS1	Homo sapiens	16-19
24899811-10	2014	Regression analysis showed vitamin D deficiency and serum 25(OH)D level to be significantly associated with the presence of RLS (odds ratio [OR] 5.085, P&lt;0.001 and OR 1.047, P=0.006, respectively).	Vitamin D	27-36	RLS1	Homo sapiens	124-127
24899811-11	2014	CONCLUSION: The present study demonstrated a possible association between vitamin D deficiency and RLS.	Vitamin D	74-83	RLS1	Homo sapiens	99-102
24899811-13	2014	Prospective vitamin D treatment studies are needed to confirm this relationship and to evaluate the efficacy of vitamin D as a treatment for RLS patients.	Vitamin D	112-121	RLS1	Homo sapiens	141-144
24622804-10	2014	Among women with complete pill counts (97% adherence), the mean decrease in CRP was 1.18 mg/mL (46%) in the vitamin D arm compared with 0.46 mg/mL (25%) in the placebo arm (P = 0.03).	Vitamin D	108-117	C-reactive protein	Homo sapiens	76-79
24792400-0	2014	Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.	Vitamin D	0-9	CD4 molecule	Homo sapiens	101-104
25031721-5	2014	Histological staining and TEM detection showed that, in both TGF-beta1 over-expressed and interfered groups, vitamin D administration alleviated the renal fibrosis, compared with the vehicle treatment.	Vitamin D	109-118	transforming growth factor, beta 1	Rattus norvegicus	61-70
25031721-7	2014	Real-time PCR analysis indicated that, when TGF-beta1 was over-expressed in diabetic nephropathy, the expressions of MCP-1 and CTGF were also up-regulated, which would be decreased by the treatment of vitamin D.	Vitamin D	201-210	transforming growth factor, beta 1	Rattus norvegicus	44-53
25031721-7	2014	Real-time PCR analysis indicated that, when TGF-beta1 was over-expressed in diabetic nephropathy, the expressions of MCP-1 and CTGF were also up-regulated, which would be decreased by the treatment of vitamin D.	Vitamin D	201-210	mast cell protease 1-like 1	Rattus norvegicus	117-122
25031721-8	2014	On the other hand, when TGF-beta1 was interfered in DN, the expressions of MCP-1 and CTGF were relatively down-regulated, which would be further lowered by vitamin D administration.	Vitamin D	156-165	transforming growth factor, beta 1	Rattus norvegicus	24-33
25031721-8	2014	On the other hand, when TGF-beta1 was interfered in DN, the expressions of MCP-1 and CTGF were relatively down-regulated, which would be further lowered by vitamin D administration.	Vitamin D	156-165	mast cell protease 1-like 1	Rattus norvegicus	75-80
24684533-8	2014	A hormone involved in aromatase activity is vitamin D, which downregulates aromatase in human RA macrophages.	Vitamin D	44-53	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	22-31
24684533-8	2014	A hormone involved in aromatase activity is vitamin D, which downregulates aromatase in human RA macrophages.	Vitamin D	44-53	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	75-84
24761763-5	2014	Furthermore, due to regulated expression of the metabolizing enzymes CYP27B1 and CYP24A1, B cells have the potential to control the local availability of active vitamin D.	Vitamin D	161-170	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
24684533-9	2014	Collectively, evidence suggests a key role of aromatase in sex hormone balance during chronic inflammation and points to the importance of vitamin D as a possible new tool for aromatase modulation.	Vitamin D	139-148	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	176-185
24606079-7	2014	Vitamin D status was a significant predictor of the IL-6 to IL-10 cytokine ratio, and those participants defined as deficient were significantly more likely to have an IL-6 to IL-10 ratio &gt;2:1 compared with those defined as sufficient.	Vitamin D	0-9	interleukin 6	Homo sapiens	52-56
24508026-1	2014	BACKGROUND: Vitamin D deficiency is associated with heart failure (HF) events, and in animal models vitamin D down-regulates renin-angiotensin-aldosterone system hormones.	Vitamin D	12-21	renin	Homo sapiens	125-130
24508026-1	2014	BACKGROUND: Vitamin D deficiency is associated with heart failure (HF) events, and in animal models vitamin D down-regulates renin-angiotensin-aldosterone system hormones.	Vitamin D	100-109	renin	Homo sapiens	125-130
24606079-8	2014	CONCLUSIONS: This study demonstrated significant associations between low vitamin D status and markers of inflammation (including the ratio of IL-6 to IL-10) within elderly adults.	Vitamin D	74-83	interleukin 6	Homo sapiens	143-147
24262718-7	2014	Similarly, vitamin D decreased estrogen receptor alpha and progesterone receptors A-to-B ratio in UtSM cells that were cocultured with THP1 cells.	Vitamin D	11-20	estrogen receptor 1	Homo sapiens	31-54
24486455-13	2014	In summary, our results suggest that ginsenosides, specifically aPPD and aPPT, inhibit the CYP3A4-mediated catabolism of active vitamin D3 in human liver and intestine, potentially providing additional vitamin D-related benefits to patients with cancer, neurodegenerative and metabolic diseases.	Vitamin D	128-137	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97
24418378-10	2014	TG, SBP, and DBP exhibited linear associations with 25(OH)D. CONCLUSIONS: Vitamin D status is related to cardiometabolic indicators in healthy men.	Vitamin D	74-83	D-box binding PAR bZIP transcription factor	Homo sapiens	13-16
25396060-0	2014	Vitamin D deficiency is common and associated with increased C-reactive protein in children and young adults with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus substudy.	Vitamin D	0-9	C-reactive protein	Homo sapiens	61-79
24747593-2	2014	In bone metabolism, vitamin D increases the plasma levels of calcium and phosphorus, regulates osteoblast and osteoclast the activity, and combats PTH hypersecretion, promoting bone formation and preventing/treating osteoporosis.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	147-150
24727903-9	2014	Individuals with vitamin D deficiency had significantly higher levels of serum GM-CSF (p = 0.04), decreased circulating activated CD4+ (p = 0.04) and CD8+ T (p = 0.04) cell frequencies than individuals with sufficient vitamin D levels.	Vitamin D	17-26	CD4 molecule	Homo sapiens	130-133
24025724-0	2014	Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats.	Vitamin D	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-28
24566583-3	2014	Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation INTRODUCTION: As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	51-70
24566583-3	2014	Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation INTRODUCTION: As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	72-75
24808866-7	2014	Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation.	Vitamin D	31-40	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	170-177
24619416-8	2014	Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-kappaB/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease.	Vitamin D	26-35	thymoma viral proto-oncogene 1	Mus musculus	108-111
24619416-8	2014	Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-kappaB/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease.	Vitamin D	26-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
24619416-8	2014	Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-kappaB/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease.	Vitamin D	153-162	thymoma viral proto-oncogene 1	Mus musculus	108-111
24619416-8	2014	Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-kappaB/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease.	Vitamin D	153-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
23584482-0	2014	PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.	Vitamin D	31-40	PDZ and LIM domain 2	Homo sapiens	0-6
23584482-0	2014	PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.	Vitamin D	123-132	PDZ and LIM domain 2	Homo sapiens	0-6
24262718-7	2014	Similarly, vitamin D decreased estrogen receptor alpha and progesterone receptors A-to-B ratio in UtSM cells that were cocultured with THP1 cells.	Vitamin D	11-20	GLI family zinc finger 2	Homo sapiens	135-139
24262718-8	2014	In addition, vitamin D treatment significantly (P &lt; .05) decreased monocyte-induced p-IkappaBalpha in cytosol and NFkappaB-p65 in the nucleus and increased IkappaBalpha in cytosol in UtSM cells.	Vitamin D	13-22	NFKB inhibitor alpha	Homo sapiens	89-101
24262718-8	2014	In addition, vitamin D treatment significantly (P &lt; .05) decreased monocyte-induced p-IkappaBalpha in cytosol and NFkappaB-p65 in the nucleus and increased IkappaBalpha in cytosol in UtSM cells.	Vitamin D	13-22	NFKB inhibitor alpha	Homo sapiens	159-171
24262718-9	2014	CONCLUSION: Our results suggest that vitamin D treatment decreases inflammation-induced cytokines and contractile-associated factors in the uterine myometrial smooth muscle cells through the NFkappaB pathway.	Vitamin D	37-46	nuclear factor kappa B subunit 1	Homo sapiens	191-199
24381012-8	2014	In both HOD patients and CCl4-treated mice, an altered vitamin D metabolism with decreased CYP27A1, CYP2R1, vitamin D-binding protein GC and increased 7-dehydrocholesterol reductase hepatic gene expression, results in decreased 25-OH vitamin D serum levels.	Vitamin D	55-64	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	91-98
24690624-8	2014	On the basis of the available evidence, an association between vitamin D concentrations and birth weight, dental caries in children, maternal vitamin D concentrations at term, and parathyroid hormone concentrations in patients with chronic kidney disease requiring dialysis is probable, but further studies and better designed trials are needed to draw firmer conclusions.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	180-199
24107003-0	2014	Effects of correction of vitamin D insufficiency on serum osteocalcin and glucose metabolism in obese children.	Vitamin D	25-34	bone gamma-carboxyglutamate protein	Homo sapiens	58-69
25097830-5	2014	Vitamin D insufficiency is highly prevalent in CKD and is associated with erythropoietin hyporesponsiveness.	Vitamin D	0-9	erythropoietin	Homo sapiens	74-88
24338253-0	2014	The effects of vitamin D on allergen-induced expression of interleukin-13 and interleukin-17 in cord blood CD4+T cells.	Vitamin D	15-24	interleukin 13	Homo sapiens	59-73
24535147-0	2014	Parathyroid hormone as a functional indicator of vitamin D sufficiency in children.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	0-19
23959712-2	2014	Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP).	Vitamin D	17-26	D-box binding PAR bZIP transcription factor	Homo sapiens	79-82
23959712-10	2014	After high-dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
23959712-10	2014	After high-dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism.	Vitamin D	82-91	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
24694221-9	2014	In the present study, we successfully developed a stable reporter gene assay, which allows assessment of the vitamin D-like chemicals toward the medaka VDRbeta.	Vitamin D	109-118	vitamin D3 receptor	Oryzias latipes	152-159
23680190-5	2014	Vitamin D levels were compared according to CD4 count, viral load and ART modalities.	Vitamin D	0-9	CD4 molecule	Homo sapiens	44-47
23680190-9	2014	CD4 count &lt;200/mul, advanced stages of disease and the current efavirenz use were independently associated with severe vitamin D deficiency (&lt;10 ng/ml).	Vitamin D	122-131	CD4 molecule	Homo sapiens	0-3
23680190-10	2014	Median vitamin D levels was 14.1 ng/dl when CD4 &gt;=200/mul, 11.5 ng/dl when CD4&lt;200 (p = 0.0003).	Vitamin D	7-16	CD4 molecule	Homo sapiens	44-47
23680190-10	2014	Median vitamin D levels was 14.1 ng/dl when CD4 &gt;=200/mul, 11.5 ng/dl when CD4&lt;200 (p = 0.0003).	Vitamin D	7-16	CD4 molecule	Homo sapiens	78-81
23680190-13	2014	The most severe vitamin D deficiencies are associated with low CD4 count, the use of efavirenz and advanced stages of disease severity.	Vitamin D	16-25	CD4 molecule	Homo sapiens	63-66
24527713-8	2014	Among vitamin D-replete subjects (25OHD status of 20 ng/mL or greater), the 97.5th percentile of plasma PTH was higher in overweight/obese subjects (51.9 vs 43.5 ng/L among normal weight subjects).	Vitamin D	6-15	parathyroid hormone	Homo sapiens	104-107
24527713-9	2014	CONCLUSIONS: The reference value for plasma PTH defined in this vitamin D-replete population was far below the value currently provided by the manufacturer (65 ng/L) and varied according to overweight status.	Vitamin D	64-73	parathyroid hormone	Homo sapiens	44-47
24050711-1	2014	OBJECTIVE: To investigate whether low vitamin D status was related to insulin resistance (IR) or impaired fasting glucose (IFG) in Korean adolescents, after adjusting for total body fat mass (FM).	Vitamin D	38-47	insulin	Homo sapiens	70-77
24661615-4	2014	Vitamin D3, (Vit D3) an active metabolite of vitamin D has been reported to inhibit the growth of number neoplasms such as prostate, breast, colorectal, leukemia, and skin cancers.	Vitamin D	45-54	vitrin	Homo sapiens	0-3
23713872-3	2014	Vitamin D also possesses a variety of effects unrelated with mineral and bone metabolism, including the regulation of arterial blood pressure and the prevention of cardiovascular complications, modulation of immunological responses, regulation of insulin production and prevention against diabetes, protection against certain cancers, renoprotection, and other beneficial actions.	Vitamin D	0-9	insulin	Homo sapiens	247-254
24818008-1	2014	This review describes the pathogenesis, clinical presentation and biochemical perturbations found in privational (nutritional) rickets and pseudo-vitamin D deficiency rickets (PDDR), an autosomal recessive condition with loss of function mutations in CYP27B1.	Vitamin D	146-155	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	176-180
24818008-3	2014	Of interest is the characteristic lack of features of rickets at birth in infants with PDDR, a finding which has also been reported in infants born to vitamin D-deficient mothers.	Vitamin D	151-160	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	87-91
24618074-6	2014	Vitamin D status was assessed by 25(OH)D3, PTH and electrolyte levels.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	43-46
24488588-4	2014	The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -alpha and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues.	Vitamin D	27-36	tumor necrosis factor	Homo sapiens	124-152
24641586-18	2014	The mechanism of vitamin D resistance remains unknown and is associated with progressive loss of eGFR.	Vitamin D	17-26	epidermal growth factor receptor	Homo sapiens	97-101
24488080-0	2014	Effect of supplemental vitamin D and calcium on serum sclerostin levels.	Vitamin D	23-32	sclerostin	Homo sapiens	54-64
24488080-2	2014	This study was carried out to determine whether vitamin D and calcium supplementation altered serum sclerostin levels in healthy older adults.	Vitamin D	48-57	sclerostin	Homo sapiens	100-110
24488080-5	2014	RESULTS: In the men, sclerostin levels increased over 2 years by 4.11+-1.81 ng/l (13.1%) in the vitamin D plus calcium-supplemented group and decreased by 3.16+-1.78 ng/l (10.9%) in the placebo group (P=0.005 for difference in change).	Vitamin D	96-105	sclerostin	Homo sapiens	21-31
24488080-9	2014	CONCLUSION: Men and women appear to have different serum sclerostin responses to vitamin D and calcium supplementation.	Vitamin D	81-90	sclerostin	Homo sapiens	57-67
24618756-6	2014	Both flavoenzyme complexes exhibit a commonality of function with all CYP enzymes and are crucial for maintaining a balance of cholesterol and vitamin D metabolites.	Vitamin D	143-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-73
24363372-0	2014	Discovery of vitamin D hormone as a negative regulator of the renin-angiotensin system.	Vitamin D	13-22	renin	Homo sapiens	62-67
24488588-4	2014	The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -alpha and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues.	Vitamin D	27-36	interleukin 6	Homo sapiens	157-170
23713878-4	2014	Vitamin D deficiency also associates with an early onset of disorders of aging, including hypertension, proteinuria, insulin resistance, immune abnormalities that enhance the propensity for viral and bacterial infections, autoimmune disorders, cancer, and multiple organ damage due to excessive systemic inflammation causing atherosclerosis, vascular stiffness, renal lesions, and impaired DNA-damage responses.	Vitamin D	0-9	insulin	Homo sapiens	117-124
24398649-0	2014	Effect of vitamin D supplementation on cathelicidin, IFN-gamma, IL-4 and Th1/Th2 transcription factors in young healthy females.	Vitamin D	10-19	interferon gamma	Homo sapiens	53-62
24456991-1	2014	Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFalpha and IL6).	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	310-318
24456991-1	2014	Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFalpha and IL6).	Vitamin D	0-9	interleukin 6	Homo sapiens	323-326
24398649-0	2014	Effect of vitamin D supplementation on cathelicidin, IFN-gamma, IL-4 and Th1/Th2 transcription factors in young healthy females.	Vitamin D	10-19	interleukin 4	Homo sapiens	64-68
24423329-1	2014	BACKGROUND: Vitamin D deficiency is thought to impair insulin action and glucose metabolism; however, previous studies have not examined ethnic differences or the influence of calcium and parathyroid hormone.	Vitamin D	12-21	insulin	Homo sapiens	54-61
24522558-7	2014	Low vitamin D concentrations in CKD stages 3-5 should be treated under consideration of serum calcium and parathyroid hormone (PTH) with calcidiol (25-cholecalciferol) and in dialysis patients (CKD 5D) with calcitriol (1,25 dihydroxycholecalciferol, activated vitamin D).	Vitamin D	4-13	parathyroid hormone	Homo sapiens	106-125
24423366-10	2014	Compared with placebo, vitamin D decreased PTH significantly by 17% before PTX (P = .01), increased lumbar spine bone mineral density by 2.5% (P = .01), and decreased C-terminal beta-CrossLaps by 22% (P &lt; .005).	Vitamin D	23-32	parathyroid hormone	Homo sapiens	43-46
24197768-0	2014	A novel compound mutation of CYP27B1 in a Chinese family with vitamin D-dependent rickets type 1A.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-36
24423366-14	2014	CONCLUSIONS: Daily supplementation with a high vitamin D dose safely improves vitamin D status and decreases PTH in PHPT patients.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	109-112
24197768-1	2014	OBJECTIVES: Mutations in the CYP27B1 gene, which encodes vitamin D 1alpha-hydroxylase, are the genetic basis of vitamin D-dependent rickets type 1A (VDDR1A, MIM 264700).	Vitamin D	57-66	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-36
24269661-2	2014	Vitamin D compounds also modulate the response to estradiol-17beta (E2) and the expression mRNAs of estrogen receptors (ERalpha and ERbeta), VDR, 25-hydroxy vitamin D3 1-alpha hydroxylase (1OHase) and lipoxygenases (12LO and 15LO).	Vitamin D	0-9	estrogen receptor 1	Homo sapiens	120-127
23283825-0	2014	Cholecalciferol administration blunts the systemic renin-angiotensin system in essential hypertensives with hypovitaminosis D. INTRODUCTION: Vitamin D plasma levels are negatively associated with blood pressure and cardiovascular mortality, and vitamin D supplementation reduces cardiovascular events.	Vitamin D	141-150	renin	Homo sapiens	51-56
24305924-3	2014	The aim of the present study was to evaluate the accuracy of PTH as a predictor of post-TT hypocalcemia in patients with vitamin D deficiency.	Vitamin D	121-130	parathyroid hormone	Homo sapiens	61-64
24088707-9	2014	On multivariate analysis, patients with insufficient vitamin D demonstrated earlier cessation of anti-TNF-alpha therapy (hazard ratio [HR], 2.13; 95% confidence interval [CI], 1.03-4.39; P = .04).	Vitamin D	53-62	tumor necrosis factor	Homo sapiens	102-111
24088707-11	2014	CONCLUSIONS: Our findings suggest that vitamin D levels may influence durability of anti-TNF-alpha induction and maintenance therapy.	Vitamin D	39-48	tumor necrosis factor	Homo sapiens	89-98
24305924-13	2014	Furthermore it was seen that the mean PTH in vitamin D sufficient hypocalcemic patients (n = 15) was 7.12 +- 1.79 and that in vitamin D deficient hypocalcemic patients (n = 26) was 16 +- 9.77 (p = 0.001) CONCLUSIONS: Our findings suggest that the fall in PTH after TT in vitamin D deficient patients is unreliable in predicting hypocalcemia and should not be relied on to plan early postoperative discharge.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	38-41
24039193-0	2014	Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids.	Vitamin D	85-94	cathelicidin antimicrobial peptide	Homo sapiens	31-65
24586387-0	2014	Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice.	Vitamin D	0-9	apolipoprotein E	Mus musculus	112-128
24586832-3	2014	We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1.	Vitamin D	264-273	SUMO specific peptidase 1	Homo sapiens	15-20
24586832-3	2014	We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1.	Vitamin D	264-273	SUMO specific peptidase 1	Homo sapiens	186-191
24586832-5	2014	In support of their function as novel modulators of the vitamin D hormonal pathway we demonstrate that both SENP1 and SENP2 can interact with VDR and reverse its modification with SUMO2.	Vitamin D	56-65	SUMO specific peptidase 1	Homo sapiens	108-113
24553867-4	2014	For example, renin, matrix metalloprotease, and tumor necrosis factor-alpha are regulated by vitamin D.	Vitamin D	93-102	renin	Homo sapiens	13-18
24553867-4	2014	For example, renin, matrix metalloprotease, and tumor necrosis factor-alpha are regulated by vitamin D.	Vitamin D	93-102	tumor necrosis factor	Homo sapiens	20-75
24553867-5	2014	Both experimental and clinical studies support the health benefits of vitamin D in the cardiovascular system, and such benefits include protecting cardiac function, lowering blood pressure, improving endothelial function, inhibiting oxidative stress, and reducing the activity of renin-angiotensin system.	Vitamin D	70-79	renin	Homo sapiens	280-285
24586387-0	2014	Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice.	Vitamin D	35-44	apolipoprotein E	Mus musculus	112-128
24624336-9	2014	In the vitamin D sufficient group, gamma-tocopherol inversely correlated (r=-0.47, p&lt;0.05) with TNF-alpha, suggesting a pro-inflammatory increase with a gamma-tocopherol decrease despite a sufficient serum 25(OH)D concentration.	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	99-108
24362231-0	2014	Association between vitamin D and Apo B concentrations in Argentinean Indian children.	Vitamin D	20-29	apolipoprotein B	Homo sapiens	34-39
24362231-7	2014	Multiple linear regression analysis showed that female gender and Apo B were significantly associated with vitamin D adjusted for confounding factors (R(2) 0.12).	Vitamin D	107-116	apolipoprotein B	Homo sapiens	66-71
24362231-8	2014	CONCLUSION: Vitamin D deficiency was associated with increased Apo B among Indian children, suggesting that it could be used as a risk marker of CVD.	Vitamin D	12-21	apolipoprotein B	Homo sapiens	63-68
24362231-1	2014	OBJECTIVE: The objective of the study was to determine the prevalence of vitamin D insufficiency and its association with non-traditional cardiovascular disease (CVD) risk factors such as Apo B in South American Indian school children.	Vitamin D	73-82	apolipoprotein B	Homo sapiens	188-193
24484740-3	2014	AIM: To assess relationship between vitamin D status and C-reactive protein (CRP), a nonspecific inflammatory marker of CSU activity.	Vitamin D	36-45	C-reactive protein	Homo sapiens	57-75
24484740-3	2014	AIM: To assess relationship between vitamin D status and C-reactive protein (CRP), a nonspecific inflammatory marker of CSU activity.	Vitamin D	36-45	C-reactive protein	Homo sapiens	77-80
24388225-6	2014	The serum IL-10 and IL-13 responses to muscular injury were significantly (both p&lt;0.05) increased in the vitamin D sufficient group.	Vitamin D	108-117	interleukin 13	Homo sapiens	20-25
24080305-2	2014	Given the demonstrated antiinflammatory function of vitamin D in multiple organ systems including trophoblast cells and placenta, we hypothesized that vitamin D deficiency contributes to the development of preeclampsia through increased inflammation, as indicated by elevated interleukin (IL)-6 concentrations.	Vitamin D	151-160	interleukin 6	Homo sapiens	276-294
24184224-1	2014	PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population.	Vitamin D	73-82	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	112-119
24256495-0	2014	Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity.	Vitamin D	11-20	insulin	Homo sapiens	83-90
24256495-7	2014	Effects of vitamin D in muscle metabolic function, specifically insulin sensitivity, are also addressed in this review.	Vitamin D	11-20	insulin	Homo sapiens	64-71
24468256-9	2014	When PBMCs from patients with positive radioallergosorbent test results were stimulated with dust mite allergen, vitamin D decreased IL-9, IL-5, and IL-13 in T-helper cells (CD4(+)).	Vitamin D	113-122	interleukin 13	Homo sapiens	149-154
24327720-7	2014	An interaction between baseline 25(OH)D and vitamin D supplementation was observed for outcome change in log CRP (month 3-month 0; P for interaction = 0.04).	Vitamin D	44-53	C-reactive protein	Homo sapiens	109-112
24239751-7	2014	Since VDR and CD86 expression are decreased in the setting of melanoma and non-melanoma skin cancers, our findings suggest a potential role of vitamin D-deficiency in the progression of skin malignancies.	Vitamin D	143-152	vitamin D receptor	Sus scrofa	6-9
24385337-5	2014	PubMed was searched for human epidemiological and clinical studies published until early 2013, investigating the relationship between vitamin D blood levels and use of drugs from one of the following groups: proton pump inhibitors (PPIs), biguanides, vitamin K antagonists, platelet aggregation inhibitors, thiazide diuretics, loop diuretics, beta-blocking agents, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II antagonists, statins, benzodiazepines, and antidepressants.	Vitamin D	134-143	angiotensin I converting enzyme	Homo sapiens	391-420
24385337-5	2014	PubMed was searched for human epidemiological and clinical studies published until early 2013, investigating the relationship between vitamin D blood levels and use of drugs from one of the following groups: proton pump inhibitors (PPIs), biguanides, vitamin K antagonists, platelet aggregation inhibitors, thiazide diuretics, loop diuretics, beta-blocking agents, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II antagonists, statins, benzodiazepines, and antidepressants.	Vitamin D	134-143	angiotensin I converting enzyme	Homo sapiens	422-425
24385337-5	2014	PubMed was searched for human epidemiological and clinical studies published until early 2013, investigating the relationship between vitamin D blood levels and use of drugs from one of the following groups: proton pump inhibitors (PPIs), biguanides, vitamin K antagonists, platelet aggregation inhibitors, thiazide diuretics, loop diuretics, beta-blocking agents, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II antagonists, statins, benzodiazepines, and antidepressants.	Vitamin D	134-143	angiotensinogen	Homo sapiens	439-453
24219894-0	2014	Investigating the causal effect of vitamin D on serum adiponectin using a Mendelian randomization approach.	Vitamin D	35-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	54-65
24219894-1	2014	BACKGROUND/OBJECTIVES: The aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach.	Vitamin D	67-76	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
24239751-3	2014	In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-kappaB, and CD86 in the epidermis of Yucatan microswine tragi.	Vitamin D	41-50	vitamin D receptor	Sus scrofa	81-84
24572452-0	2014	Insulin resistance via modification of PGC1alpha function identifying a possible preventive role of vitamin D analogues in chronic inflammatory state of obesity.	Vitamin D	100-109	insulin	Homo sapiens	0-7
24632644-0	2014	[Effect of vitamin D correction on insulin resistance in patients with coronary heart disease and metabolic syndrome].	Vitamin D	11-20	insulin	Homo sapiens	35-42
24463450-4	2014	We then applied information from this analysis to classify human breast tumors based on normal cell types into 4 major subtypes, HR0-HR3, which were differentiated by vitamin D, androgen, and estrogen hormone receptor (HR) expression.	Vitamin D	167-176	nuclear receptor subfamily 4 group A member 1	Homo sapiens	129-131
24053724-5	2014	Obese patients showed a vitamin D status that was compatible with moderate depletion, thus correlating negatively with parathyroid hormone (PTH) and positively with CTX.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	119-138
23857798-0	2014	In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	74-77
23857798-2	2014	The majority of vitamin D in circulation is bound to vitamin D-binding protein (DBP) and albumin, and recent genetic studies have demonstrated that serum DBP is a major determinant of 25(OH)D concentrations in adults.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Homo sapiens	80-83
23857798-2	2014	The majority of vitamin D in circulation is bound to vitamin D-binding protein (DBP) and albumin, and recent genetic studies have demonstrated that serum DBP is a major determinant of 25(OH)D concentrations in adults.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Homo sapiens	154-157
23857798-9	2014	These findings provide evidence that in a largely vitamin D-sufficient cohort, the biological effect of vitamin D on PTH levels is mainly independent of DBP concentration.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	117-120
24496360-10	2014	CONCLUSION: Insulin resistance was a better independent risk factor for the presence of vitamin D deficiency than SHBG.	Vitamin D	88-97	insulin	Homo sapiens	12-19
24572452-0	2014	Insulin resistance via modification of PGC1alpha function identifying a possible preventive role of vitamin D analogues in chronic inflammatory state of obesity.	Vitamin D	100-109	PPARG coactivator 1 alpha	Homo sapiens	39-48
24411940-3	2014	Using comparative metabolomics, we identified endogenous steroids that act as ligands of the C. elegans NHR, DAF-12, a vitamin D and liver X receptor homolog regulating larval development, fat metabolism, and lifespan.	Vitamin D	119-128	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	109-115
24011542-0	2014	Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate.	Vitamin D	29-38	amyloid beta precursor protein	Homo sapiens	77-89
24498064-1	2014	Vitamin D binding protein (DBP)/group-specific component (Gc), correlates positively with serum vitamin D metabolites, and phenotype influences serum 25-hydroxyvitamin D (S-25(OH)D) concentration.	Vitamin D	96-105	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
24190897-3	2014	DKKL1 mRNA was repressed 49-72% by 1,25D in primary human and CCD-1106 KERTr keratinocytes; a functional vitamin D responsive element (VDRE) was identified at -9590 bp in murine Soggy.	Vitamin D	105-114	dickkopf-like 1	Mus musculus	178-183
24247221-3	2014	Mice with disrupted vitamin D action--owing to gene deletion of the nuclear receptor vitamin D receptor (Vdr) or the gene encoding 1alpha-hydroxylase (Cyp27b1)--lose fat mass over time owing to an increase in energy expenditure, whereas mice with increased Vdr-mediated signalling in adipose tissue become obese.	Vitamin D	20-29	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	151-158
24011542-2	2014	Recently, its has been proposed that the combination of memantine with vitamin D, a neurosteroid hormone, may prevent amyloid-beta and glutamate neurotoxicity.	Vitamin D	71-80	amyloid beta precursor protein	Homo sapiens	118-130
24011542-3	2014	Here, our purpose was to examine the potential protective effects of memantine and vitamin D against amyloid-beta peptide and glutamate toxicity in cortical neuronal cultures.	Vitamin D	83-92	amyloid beta precursor protein	Homo sapiens	101-113
24131546-3	2014	AIM: To determine the effects of plasma exchange on vitamin D binding protein (DBP) and associated vitamin D metabolites.	Vitamin D	52-61	D-box binding PAR bZIP transcription factor	Homo sapiens	79-82
24475177-6	2014	Vitamin D supplementation had no significant effects on RV replication, but potentiated secretion of CXCL8 and CXCL10 from infected or uninfected cells.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
24475177-8	2014	Similar effects were seen for 25(OH)D. In addition to altering morphology, higher concentrations of vitamin D significantly upregulated small proline-rich protein (SPRR1beta) expression (6.3 fold-induction, p&lt;0.01), suggestive of squamous metaplasia.	Vitamin D	100-109	complement component 4 binding protein alpha	Homo sapiens	142-162
24436433-5	2014	Experimental studies have established a role for vitamin D metabolites in pathways that are integral to cardiovascular function and disease, including inflammation, thrombosis, and the renin-angiotensin system.	Vitamin D	49-58	renin	Homo sapiens	185-190
24730053-3	2014	METHODS: Twenty-three single-nucleotide polymorphisms (SNPs) of five vitamin D-related genes (CYP27A1, CYP2R1, CYP27B1, GC and VDR) were genotyped in 1442 Chinese children with eczema and 1231 non-allergic controls.	Vitamin D	69-78	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	111-118
24783350-2	2014	Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein with many important functions, including sequestration of actin, modulation of immune and inflammatory responses, binding of fatty acids, and control of bone development.	Vitamin D	25-34	D-box binding PAR bZIP transcription factor	Homo sapiens	48-51
23941558-6	2014	We next demonstrated that vitamin D, 25(OH)D, and 1,25(OH)2D significantly reduced prostaglandin (PG)E2 production by human lung fibroblasts (HFL-1) but had no effect on transforming growth factor beta1, vascular endothelial growth factor, or fibronectin production.	Vitamin D	26-35	vascular endothelial growth factor A	Homo sapiens	204-238
23941558-6	2014	We next demonstrated that vitamin D, 25(OH)D, and 1,25(OH)2D significantly reduced prostaglandin (PG)E2 production by human lung fibroblasts (HFL-1) but had no effect on transforming growth factor beta1, vascular endothelial growth factor, or fibronectin production.	Vitamin D	26-35	fibronectin 1	Homo sapiens	243-254
23941558-7	2014	Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	59-67
23941558-7	2014	Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2.	Vitamin D	154-163	interleukin 1 beta	Homo sapiens	59-67
24857149-0	2014	Hype versus hope: metformin and vitamin D as anticancer agents.	Vitamin D	32-41	FIC domain protein adenylyltransferase	Homo sapiens	0-4
24854296-0	2014	Novel, selective vitamin D analog suppresses parathyroid hormone in uremic animals and postmenopausal women.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	45-64
24858401-1	2014	UNLABELLED: Risks of low vitamin D status in Kuwaiti adolescent girls are high parathyroid hormone (PTH), high waist/hip ratio, veiling and not having a private room.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	79-98
23869781-9	2014	Based on these results, we conclude that (1) high affinity for VDR, (2) resistance to CYP24A1-dependent catabolism, (3) low affinity for DBP, and (4) low calcemic effect may be required for designing potent vitamin D analogs for cancer treatment.	Vitamin D	207-216	D-box binding PAR bZIP transcription factor	Homo sapiens	137-140
24858401-1	2014	UNLABELLED: Risks of low vitamin D status in Kuwaiti adolescent girls are high parathyroid hormone (PTH), high waist/hip ratio, veiling and not having a private room.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	100-103
24715441-4	2014	PURPOSE: Optimal vitamin D status for bone health has been inferred from the determination of serum 25OHD levels below which there is an increase in serum parathyroid hormone (PTH).	Vitamin D	17-26	parathyroid hormone	Homo sapiens	155-174
24715441-4	2014	PURPOSE: Optimal vitamin D status for bone health has been inferred from the determination of serum 25OHD levels below which there is an increase in serum parathyroid hormone (PTH).	Vitamin D	17-26	parathyroid hormone	Homo sapiens	176-179
26155133-7	2014	Also, higher insulin sensitivity was associated with higher concentrations of vitamin D.	Vitamin D	78-87	insulin	Homo sapiens	13-20
24901094-0	2014	Serum osteocalcin is associated with dietary vitamin D, body weight and serum magnesium in postmenopausal women with and without significant coronary artery disease.	Vitamin D	45-54	bone gamma-carboxyglutamate protein	Homo sapiens	6-17
24901094-3	2014	We aimed to examine the relationship between serum osteocalcin and vitamin D status in postmenopausal women with and without angiographic evidence of coronary artery disease (CAD).	Vitamin D	67-76	bone gamma-carboxyglutamate protein	Homo sapiens	51-62
24901094-10	2014	Serum osteocalcin was significantly correlated with dietary vitamin D in all subgroups (r=-0.172, p&lt;0.05) and positively correlated among the patients (r=0.269, p=0.01).	Vitamin D	60-69	bone gamma-carboxyglutamate protein	Homo sapiens	6-17
24901094-11	2014	Serum magnesium, alkaline phosphatase, dietary vitamin D, and body weight were independent variables of serum osteocalcin level.	Vitamin D	47-56	bone gamma-carboxyglutamate protein	Homo sapiens	110-121
24901094-12	2014	In conclusion, elevated levels of serum C reactive protein and vitamin D were associated with low serum osteocalcin levels.	Vitamin D	63-72	bone gamma-carboxyglutamate protein	Homo sapiens	104-115
24164282-2	2014	We sought to clarify the influence of vitamin D in modulating angiotensin II-dependent arterial stiffness.	Vitamin D	38-47	angiotensinogen	Homo sapiens	62-76
23701502-0	2014	The relationship between vitamin D and PTH levels and cardiovascular risk in the elderly hypertensives.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	39-42
22826443-2	2014	Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system.	Vitamin D	0-9	renin	Homo sapiens	35-40
24164282-8	2014	Compared with sufficient vitamin D status, vitamin D deficiency was associated with a decreased arterial response to angiotensin II challenge (Deltabrachial pulse wave velocity: 0.48 +- 0.44 m/s versus 1.95 +- 0.22 m/s, p=0.004; Deltaaortic augmentation index: 9.4 +- 3.4% versus 14.2 +- 2.7%, p=0.3), which persisted for brachial pulse wave velocity response after adjustment for covariates (p=0.03).	Vitamin D	43-52	angiotensinogen	Homo sapiens	117-131
24164282-9	2014	Vitamin D deficiency is associated with increased arterial stiffness in healthy humans, possibly through an angiotensin II-dependent mechanism.	Vitamin D	0-9	angiotensinogen	Homo sapiens	108-122
25812355-11	2014	Vitamin D correlated negatively with IgE level (r = -0.45, P &lt; 0.05), meanwhile it was insignificantly correlated with age and duration of illness (r = -0.117 and 0.34 respectively, P &gt; 0.05).	Vitamin D	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	37-40
24205902-1	2014	The aim was to determine the prevalence of vitamin D insufficiency in pregnant immigrant women assessed by the levels of 25-hydroxyvitamin D, parathyroid hormone (PTH) and alkaline phosphatase (ALP) as well as the correlation to musculoskeletal pain.	Vitamin D	43-52	alkaline phosphatase, placental	Homo sapiens	194-197
25008764-1	2014	The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases.	Vitamin D	26-35	cathelicidin antimicrobial peptide	Homo sapiens	64-98
25008764-1	2014	The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases.	Vitamin D	144-153	cathelicidin antimicrobial peptide	Homo sapiens	64-98
24699387-7	2014	These same genes were associated with several late-life phenotypes: VDR-BsmI, TaqI and ApaI determined the relationship between dietary vitamin D and both insulin (P &lt; 0.0001/BB, 0.0007/tt and 0.0173/AA, respectively) and systolic blood pressure (P = 0.0290/Bb, 0.0299/Tt and 0.0412/AA, respectively), making them important early and late in the lifecycle.	Vitamin D	136-145	insulin	Homo sapiens	155-162
25242259-0	2014	Effect of high parathyroid hormone level on bone mineral density in a vitamin D-sufficient population: Korea National Health and Nutrition Examination Survey 2008-2010.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	15-34
25242259-6	2014	High PTH level was found in 50% of vitamin D-deficient subjects and 35% of vitamin D-sufficient subjects.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	5-8
25242259-6	2014	High PTH level was found in 50% of vitamin D-deficient subjects and 35% of vitamin D-sufficient subjects.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	5-8
25242259-7	2014	In the vitamin D-deficient group, subjects with normal PTH level had higher total hip and spine BMD than those with high PTH after adjusting for multiple confounding factors, regardless of gender.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	55-58
25242259-7	2014	In the vitamin D-deficient group, subjects with normal PTH level had higher total hip and spine BMD than those with high PTH after adjusting for multiple confounding factors, regardless of gender.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	121-124
25242259-8	2014	In the vitamin D-sufficient group, only women with high PTH showed lower total hip and spine BMD than those with normal PTH.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	56-59
25242259-8	2014	In the vitamin D-sufficient group, only women with high PTH showed lower total hip and spine BMD than those with normal PTH.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	120-123
25242259-9	2014	Multivariable linear regression analysis found that PTH level was independently associated with total hip BMD in vitamin D-sufficient women as well as vitamin D-insufficient women, but no association was found in men.	Vitamin D	113-122	parathyroid hormone	Homo sapiens	52-55
25242259-9	2014	Multivariable linear regression analysis found that PTH level was independently associated with total hip BMD in vitamin D-sufficient women as well as vitamin D-insufficient women, but no association was found in men.	Vitamin D	151-160	parathyroid hormone	Homo sapiens	52-55
25242259-10	2014	In conclusion, high serum PTH level has an additive detrimental effect on BMD in postmenopausal women even though they had sufficient vitamin D levels.	Vitamin D	134-143	parathyroid hormone	Homo sapiens	26-29
25254046-2	2014	The aim of this study was to investigate the relationship between serum vitamin D and insulin resistance in Chinese subjects without diabetes mellitus.	Vitamin D	72-81	insulin	Homo sapiens	86-93
24987416-4	2014	One of the mechanisms by which DBP may alter bone health involves regulating vitamin D bioavailability.	Vitamin D	77-86	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
24987416-5	2014	DBP-bound vitamin is thought to be relatively unavailable to target tissues, and thus alterations in DBP levels or affinity could lead to changes in vitamin D bioactivity.	Vitamin D	149-158	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
24987416-5	2014	DBP-bound vitamin is thought to be relatively unavailable to target tissues, and thus alterations in DBP levels or affinity could lead to changes in vitamin D bioactivity.	Vitamin D	149-158	D-box binding PAR bZIP transcription factor	Homo sapiens	101-104
25045351-8	2014	Thus, the ADVIA Centaur Vitamin D Total assay demonstrates acceptable performance compared with an LC-MS/MS method for populations containing different amounts of DBP.	Vitamin D	24-33	D-box binding PAR bZIP transcription factor	Homo sapiens	163-166
24198221-0	2014	Effect of a randomised controlled vitamin D trial on insulin resistance and glucose metabolism in patients with type 2 diabetes mellitus.	Vitamin D	34-43	insulin	Homo sapiens	53-60
24899892-1	2014	Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses.	Vitamin D	65-74	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
25548714-0	2014	Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D 2 (300,000 IU).	Vitamin D	72-81	sclerostin	Homo sapiens	33-43
23736361-0	2014	Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.	Vitamin D	0-9	insulin	Homo sapiens	120-127
23761326-2	2014	The main objective of this trial was to measure the effect of different doses of vitamin D3 on serum 25OHD and serum parathyroid hormone (PTH) in young women with vitamin D insufficiency (serum 25OHD &lt;= 20 ng/mL (50 nmol/L).	Vitamin D	81-90	parathyroid hormone	Homo sapiens	117-136
23761326-2	2014	The main objective of this trial was to measure the effect of different doses of vitamin D3 on serum 25OHD and serum parathyroid hormone (PTH) in young women with vitamin D insufficiency (serum 25OHD &lt;= 20 ng/mL (50 nmol/L).	Vitamin D	81-90	parathyroid hormone	Homo sapiens	138-141
24377473-2	2014	It has been shown that vitamin D is a major regulator of the expression of human antimicrobial peptide cathelicidin LL-37, which has a critical role in inflammatory cascade in psoriasis.	Vitamin D	23-32	cathelicidin antimicrobial peptide	Homo sapiens	116-121
24772394-0	2014	The effects of vitamin D on the renin-angiotensin system.	Vitamin D	15-24	renin	Homo sapiens	32-37
24314866-1	2014	The active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is synthesized by the 1alpha-hydroxylase, which is encoded by the Cyp27B1 gene.	Vitamin D	19-28	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	135-142
24105653-6	2014	Vitamin D restrained the expression of both NFkappaB- and STAT1-induced antiviral genes.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	44-53
24105653-7	2014	However, while NFkappaB control by vitamin D remained intact, both RSV-induced phosphorylation of STAT1 and expression of its downstream targets, IRF1 and IRF7, escaped vitamin D control in FokI epithelial cells.	Vitamin D	169-178	interferon regulatory factor 1	Homo sapiens	146-150
24105653-8	2014	The poor capacity of vitamin D to regulate IRF1 in FokI VDR-expressing cells was recapitulated using blood samples from normal and FokI VDR-genotyped healthy donors.	Vitamin D	21-30	interferon regulatory factor 1	Homo sapiens	43-47
24140383-0	2014	Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial.	Vitamin D	11-20	insulin	Homo sapiens	40-47
24140383-1	2014	OBJECTIVE: This triple-masked controlled trial aimed to assess the effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in obese children and adolescents.	Vitamin D	78-87	insulin	Homo sapiens	107-114
24140383-8	2014	After the trial, in the vitamin D group, serum insulin and triglyceride concentrations, as well as HOM -IR and C-MetS decreased significantly, both when compared with the baseline and with the placebo group.	Vitamin D	24-33	insulin	Homo sapiens	47-54
24140383-10	2014	CONCLUSION: The present findings support the favorable effects of vitamin D supplementation on reducing insulin resistance and cardiometabolic risk factors in obese children.	Vitamin D	66-75	insulin	Homo sapiens	104-111
25548714-16	2014	Supraphysiological concentration in 1,25 (OH)2 vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling.	Vitamin D	47-56	sclerostin	Homo sapiens	114-124
25061262-3	2014	We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways.	Vitamin D	28-37	interleukin 31	Homo sapiens	65-70
24988607-4	2014	Vitamin D suppresses parathyroid hormone secretion, adaptive immune response, cell proliferation, and at the same time promotes insulin secretion, innate immune response and stimulates cell differentiation.	Vitamin D	0-9	insulin	Homo sapiens	128-135
23769706-1	2014	OBJECTIVES: To determine the knowledge and management of vitamin D (Vit D) in primary care (PC).	Vitamin D	57-66	vitrin	Homo sapiens	68-71
24193406-8	2014	NaS1 expression is down-regulated in the renal cortex by high sulfate diet, hypothyroidism, vitamin D depletion, glucocorticoids, hypokalemia, metabolic acidosis, and NSAIDs and up-regulated by low sulfate diet, thyroid hormone, vitamin D supplementation, growth hormone, chronic renal failure, and during post-natal growth.	Vitamin D	92-101	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	0-4
24193406-8	2014	NaS1 expression is down-regulated in the renal cortex by high sulfate diet, hypothyroidism, vitamin D depletion, glucocorticoids, hypokalemia, metabolic acidosis, and NSAIDs and up-regulated by low sulfate diet, thyroid hormone, vitamin D supplementation, growth hormone, chronic renal failure, and during post-natal growth.	Vitamin D	229-238	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	0-4
25489316-3	2014	Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system.	Vitamin D	0-9	renin	Homo sapiens	35-40
23954530-9	2013	Given that 25(OH)D is hydroxylated by CYP27B1 to the bioactive 1,25(OH)2D form, and CYP24A1 catabolizes both 25(OH)D and 1,25(OH)2D to the inactive metabolites, respectively, our data indicate that the elevated activity of CYP24A1 in the placenta may play a key role in the development of vitamin D deficiency in GDM.	Vitamin D	289-298	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	38-45
24313936-9	2013	Supplemental vitamin D attenuated (P &lt; 0.05) the immediate and delayed (48-h, 72-h, or 168-h) increase in circulating biomarkers representative of muscle damage (ALT or AST) without ameliorating muscle soreness (P &gt; 0.05).	Vitamin D	13-22	solute carrier family 17 member 5	Homo sapiens	172-175
24304609-1	2013	We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	118-137
24304609-1	2013	We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	139-142
24334134-0	2013	[Clinical value of two methods to measure parathyroid hormone in chronic renal insufficiency, considering vitamin D metabolism].	Vitamin D	106-115	parathyroid hormone	Homo sapiens	42-61
24334134-2	2013	AIM: To compare parathyroid hormone levels measured by two assays in correlation with vitamin D supply.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	16-35
24334134-9	2013	CONCLUSIONS: Biointact parathyroid hormone levels better reflect the vitamin D supply and bone metabolism than intact levels, especially in hemodialysed patients.	Vitamin D	69-78	parathyroid hormone	Homo sapiens	23-42
23973664-0	2013	The Orosomucoid 1 protein is involved in the vitamin D - mediated macrophage de-activation process.	Vitamin D	45-54	orosomucoid 1	Homo sapiens	4-17
24112673-9	2013	A parathyroid hormone level outside of the reference range may indicate a need for more aggressive postoperative calcium supplementation and treatment with activated vitamin D.	Vitamin D	166-175	parathyroid hormone	Homo sapiens	2-21
24132976-2	2013	OBJECTIVE: This study was designed to assess the effects of vitamin D supplementation on metabolic profiles, high-sensitivity C-reactive protein, and biomarkers of oxidative stress in pregnant women with GDM.	Vitamin D	60-69	C-reactive protein	Homo sapiens	126-144
24521626-0	2013	Serum vitamin-D predicts insulin resistance in individuals with prediabetes.	Vitamin D	6-15	insulin	Homo sapiens	25-32
24090688-7	2013	On simple linear analysis, the vitamins found associated with serum IGF-1 levels were: folates (r: -0.25; p = 0.003); vitamin E (r: -0.21; p = 0.01); vitamin D (r: -0.17; p = 0.03); and riboflavin (r: -0.16; p=0.03).	Vitamin D	150-159	insulin like growth factor 1	Homo sapiens	68-73
24173581-3	2013	The various cardiovascular protective actions of vitamin D such as anti-diabetic and anti-hypertensive effects including renin suppression as well as protection against atherosclerosis and heart diseases are well defined in previous experimental studies.	Vitamin D	49-58	renin	Homo sapiens	121-126
24245571-3	2013	Concerning the synthesis of vitamin D, the hydroxylases CYP2R1, CYP27B1 and CYP24A1 play a critical role, and the latter molecule determines the biological half-life of 1,25(OH)2 D3 , which is synthesized in the proximal renal tubules.	Vitamin D	28-37	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	64-71
24245571-9	2013	CONCLUSION: We thus conclude that upregulated gene expression of the catabolizing CYP24A1 as well as the synthesizing CYP2R1 and CYP27B1 may lead to a misbalance of vitamin D metabolites in ccRCC and thus contributing to its pathogenesis.	Vitamin D	165-174	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-136
24067280-8	2013	A strong association with increased risk of the disease has been observed for a rare variant in the CYP27B1 gene encoding a vitamin D-activating enzyme.	Vitamin D	124-133	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	100-107
24910833-2	2013	VDDR type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1-alpha-hydroxylase.	Vitamin D	53-62	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-4
24910833-2	2013	VDDR type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1-alpha-hydroxylase.	Vitamin D	53-62	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	13-17
24910833-3	2013	Patients with VDDR-I have mutations of chromosome 12 that affect the gene for the enzyme 1-alpha-hydroxylase, resulting in decreased levels of 1,25(OH) vitamin D.	Vitamin D	152-161	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	14-18
23813327-6	2013	Our results indicate that vitamin D has protective effects on diabetes-induced aortic injury and attenuates the expressions of TLR4, MyD88, and NF-kappaB in diabetic rats.	Vitamin D	26-35	toll-like receptor 4	Rattus norvegicus	127-131
24521626-1	2013	BACKGROUND &amp; OBJECTIVES: Patients with diabetes and vitamin-D insufficiency have increased insulin resistance.	Vitamin D	56-65	insulin	Homo sapiens	95-102
24521626-3	2013	The aim of this study was to find the occurrence of vitamin-D insufficiency/deficiency among individuals with prediabetes and to evaluate the relationship between vitamin-D status and insulin resistance.	Vitamin D	163-172	insulin	Homo sapiens	184-191
24521626-8	2013	Individuals with the lowest vitamin-D levels (&lt;10 ng/ml) had the highest insulin resistance (HOMA2-IR: 2.04 +- 0.67).	Vitamin D	28-37	insulin	Homo sapiens	76-83
24521626-13	2013	INTERPRETATIONS &amp; CONCLUSIONS: Vitamin-D deficiency/insufficiency may have some role in the development/worsening of insulin resistance in individuals with prediabetes in our country who have a high cardiovascular risk.	Vitamin D	35-44	insulin	Homo sapiens	121-128
24445125-7	2013	Studies in hypoparathyroid subjects demonstrate that PTH(1-34) and PTH(1-84) lower or abolish supplemental calcium and vitamin D requirements as well as increase markers of bone turnover.	Vitamin D	119-128	parathyroid hormone	Homo sapiens	53-56
24445125-7	2013	Studies in hypoparathyroid subjects demonstrate that PTH(1-34) and PTH(1-84) lower or abolish supplemental calcium and vitamin D requirements as well as increase markers of bone turnover.	Vitamin D	119-128	parathyroid hormone	Homo sapiens	67-70
23987236-1	2013	BACKGROUND: Despite extensive study, the role of vitamin D in insulin resistance and secretion remains unclear.	Vitamin D	49-58	insulin	Homo sapiens	62-69
25566425-6	2013	Serum vitamin D levels were negatively associated with body fatness parameters, blood pressures, total cholesterol, triglycerides, and insulin and positively associated with high-density lipoprotein cholesterol and CRF.	Vitamin D	6-15	insulin	Homo sapiens	135-142
23987236-9	2013	Whether this reflects residual confounding in cross-sectional analyses or the short-term nature of the relationship between vitamin D and insulin sensitivity will require trials with repeated measures of these factors.	Vitamin D	124-133	insulin	Homo sapiens	138-145
24237081-0	2013	Vitamin D and tuberculosis: hope or hype?	Vitamin D	0-9	FIC domain protein adenylyltransferase	Homo sapiens	36-40
23685025-0	2013	Does insulin resistance in type 2 diabetes alter vitamin D status?	Vitamin D	49-58	insulin	Homo sapiens	5-12
23685025-1	2013	AIMS: Data on changes of vitamin D due to insulin resistance are conflicting.	Vitamin D	25-34	insulin	Homo sapiens	42-49
23685025-2	2013	We assessed vitamin D concentrations and parameters of glycemia and mineral homeostasis in patients with insulin resistant type 2 diabetes and in matched normal controls.	Vitamin D	12-21	insulin	Homo sapiens	105-112
25340161-1	2014	INTRODUCTION: Studies have revealed the association between vitamin D deficiency and changes in blood glucose and insulin levels as well as sensitivity of the target tissues to insulin.	Vitamin D	60-69	insulin	Homo sapiens	114-121
24264043-5	2013	In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined.	Vitamin D	59-68	occludin	Mus musculus	128-136
24264043-5	2013	In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined.	Vitamin D	59-68	tight junction protein 1	Mus musculus	138-142
24135218-1	2013	BACKGROUND AND OBJECTIVES: Experimental studies show that 25 (OH) vitamin D is a suppressor of renin biosynthesis and that vitamin D deficiency has been associated with CKD progression.	Vitamin D	66-75	renin	Homo sapiens	95-100
24012652-0	2013	Prevalence of vitamin D deficiency and consequences for PTH reference values.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	56-59
24012652-1	2013	Reference values of PTH depend on vitamin D status of the reference population.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	20-23
24012652-8	2013	The relation between vitamin D and PTH was independent of age, gender, BMI and kidney function.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	35-38
24217116-2	2013	We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth factor receptor (EGFR) mutations display elevated VDR expression (VDRhigh) and are vitamin D-sensitive.	Vitamin D	182-191	epidermal growth factor receptor	Homo sapiens	82-114
24217116-2	2013	We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth factor receptor (EGFR) mutations display elevated VDR expression (VDRhigh) and are vitamin D-sensitive.	Vitamin D	182-191	epidermal growth factor receptor	Homo sapiens	116-120
24036370-0	2013	1,25-Dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade.	Vitamin D	14-23	AKT serine/threonine kinase 1	Homo sapiens	105-108
23909945-0	2013	Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study.	Vitamin D	0-9	insulin	Homo sapiens	90-97
23909945-4	2013	Cross-sectional and longitudinal multivariate logistic regression models were used to determine the association of plasma vitamin D with insulin resistance, adjusting for potential confounders.	Vitamin D	122-131	insulin	Homo sapiens	137-144
23909945-6	2013	In cross-sectional multivariate analyses, participants who had higher plasma vitamin D (65 nmol/l) had lower odds of prevalent insulin resistance than participants with lower plasma vitamin D (25 nmol/l) (odds ratio 0.70, 95% CI 0.57-0.85).	Vitamin D	77-86	insulin	Homo sapiens	127-134
23909945-8	2013	In longitudinal multivariate analyses, individuals with higher plasma vitamin D at baseline had lower odds of incident insulin resistance, but this was not significant (odds ratio 0.85, 95% CI 0.63-1.14).	Vitamin D	70-79	insulin	Homo sapiens	119-126
23909945-9	2013	CONCLUSIONS: Vitamin D insufficiency is common in individuals with Type 1 diabetes and may increase risk for insulin resistance.	Vitamin D	13-22	insulin	Homo sapiens	109-116
23909945-10	2013	Additional prospective studies are needed to determine the association between plasma vitamin D and insulin resistance, and to further examine the role of adiposity on this association.	Vitamin D	86-95	insulin	Homo sapiens	100-107
24007780-5	2013	Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06).	Vitamin D	10-19	tumor necrosis factor	Homo sapiens	98-107
24007780-5	2013	Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06).	Vitamin D	10-19	interleukin 1 beta	Homo sapiens	136-144
24036370-0	2013	1,25-Dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade.	Vitamin D	14-23	mechanistic target of rapamycin kinase	Homo sapiens	109-113
24064695-2	2013	OBJECTIVE: Our objective was to evaluate the influence of calcium and vitamin D supplementation on PTH and bone turnover.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	99-102
24064695-9	2013	There was a decline in PTH in the vitamin D groups in the fasting state compared with placebo.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	23-26
24064695-10	2013	Suppression of PTH was greater after a calcium load in the vitamin D groups.	Vitamin D	59-68	parathyroid hormone	Homo sapiens	15-18
24064695-12	2013	CONCLUSIONS: Fasting PTH declines with vitamin D supplementation.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	21-24
23403039-6	2013	Patients who took oral vitamin D supplementation had lower Crohn"s disease activity index (p&lt;0.05) and C-reactive protein (p=0.07) than non-users.	Vitamin D	23-32	C-reactive protein	Homo sapiens	106-124
24392366-4	2013	Hence, low Vitamin D levels are implicated in decreased insulin secretion and increased insulin resistance.	Vitamin D	11-20	insulin	Homo sapiens	56-63
24392366-12	2013	There was significant negative correlation between Vitamin D status and insulin levels, and insulin resistance (p&lt;0.01).	Vitamin D	51-60	insulin	Homo sapiens	72-79
24044969-0	2013	MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase.	Vitamin D	17-26	septin 4	Homo sapiens	0-4
24392366-13	2013	IMPLICATION: A significant negative correlation between Vitamin D status and insulin levels suggest that the supplementation of Vitamin D has the potential to increase insulin sensitivity and lower the risk of developing type 2 diabetes mellitus.	Vitamin D	56-65	insulin	Homo sapiens	77-84
24392366-13	2013	IMPLICATION: A significant negative correlation between Vitamin D status and insulin levels suggest that the supplementation of Vitamin D has the potential to increase insulin sensitivity and lower the risk of developing type 2 diabetes mellitus.	Vitamin D	56-65	insulin	Homo sapiens	168-175
24392366-13	2013	IMPLICATION: A significant negative correlation between Vitamin D status and insulin levels suggest that the supplementation of Vitamin D has the potential to increase insulin sensitivity and lower the risk of developing type 2 diabetes mellitus.	Vitamin D	128-137	insulin	Homo sapiens	77-84
24392366-13	2013	IMPLICATION: A significant negative correlation between Vitamin D status and insulin levels suggest that the supplementation of Vitamin D has the potential to increase insulin sensitivity and lower the risk of developing type 2 diabetes mellitus.	Vitamin D	128-137	insulin	Homo sapiens	168-175
24078159-1	2013	Obesity, insulin resistance, and hyperandrogenism are considered crucial parameters of polycystic ovary syndrome (PCOS) which might be related to vitamin D metabolism.	Vitamin D	146-155	insulin	Homo sapiens	9-16
24550943-5	2013	Post replacement Vitamin D levels increased significantly and insulin, HbA1c, and HOMA-IR decreased significantly following Vitamin D replacement.	Vitamin D	124-133	insulin	Homo sapiens	62-69
24550943-7	2013	In Vitamin D deficient patients, supplementation treatment improved insulin resistance and glycemic parameters.	Vitamin D	3-12	insulin	Homo sapiens	68-75
23360833-13	2013	Studies are needed to determine whether CVD risk, including insulin resistance, could be improved with vitamin D supplementation.	Vitamin D	103-112	insulin	Homo sapiens	60-67
24550943-8	2013	Vitamin D replacement may be a promising intervention for the primary prevention of insulin resistance syndromes.	Vitamin D	0-9	insulin	Homo sapiens	84-91
23789983-2	2013	Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF-I serum values in population-based cohorts of healthy subjects.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	49-54
24005315-0	2013	Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	32-36
24005315-1	2013	OBJECTIVES: Previous studies suggested that vitamin D modulates circulating IGF1.	Vitamin D	44-53	insulin like growth factor 1	Homo sapiens	76-80
24005315-4	2013	The frequency of IGF1 values &gt;=50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4+-16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured.	Vitamin D	87-96	insulin like growth factor 1	Homo sapiens	17-21
24005315-9	2013	Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between &gt;=15 ng/ml 25(OH)D and IGF1 &gt;=50th percentile (OR 4.4, 95% CI 1.0-18.8, P&lt;0.05).	Vitamin D	74-83	insulin like growth factor 1	Homo sapiens	261-265
24005315-11	2013	CONCLUSIONS: Vitamin D increases circulating IGF1 in adults.	Vitamin D	13-22	insulin like growth factor 1	Homo sapiens	45-49
24005315-12	2013	As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD.	Vitamin D	22-31	insulin like growth factor 1	Homo sapiens	74-78
23790578-0	2013	[Relation between parathyroid hormone and cardiovascular risk in patients with vitamin D deficiency].	Vitamin D	79-88	parathyroid hormone	Homo sapiens	18-37
23789983-10	2013	Current evidence indicates that, in breast tumours, vitamin D modulates the IGF-I/IGFBP ratio to decrease proliferation and increase apoptosis.	Vitamin D	52-61	insulin like growth factor 1	Homo sapiens	76-81
23962009-10	2013	The only factors found to be associated with vitamin D deficiency were season of sample, ethnicity, and PTH levels.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	104-107
23962009-14	2013	Initial post-transplant period and high PTH are significantly associated with vitamin D deficiency.	Vitamin D	78-87	parathyroid hormone	Homo sapiens	40-43
23999068-0	2013	Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children.	Vitamin D	37-46	parathyroid hormone	Homo sapiens	51-70
23999068-9	2013	CONCLUSION: Vitamin D deficiency, based on PTH elevation, was best defined by a 25OHD level of &lt; 34 nmol/l.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	43-46
24026893-9	2013	One year of vitamin D supplementation resulted in lower parathyroid hormone (PTH) (40 (34-52) vs 49 (38-66) ng/l) and higher 25-OH-D (76 (65-93) vs 49 (40-62) nmol/l; P&lt;0.05).	Vitamin D	12-21	parathyroid hormone	Homo sapiens	56-75
24026893-9	2013	One year of vitamin D supplementation resulted in lower parathyroid hormone (PTH) (40 (34-52) vs 49 (38-66) ng/l) and higher 25-OH-D (76 (65-93) vs 49 (40-62) nmol/l; P&lt;0.05).	Vitamin D	12-21	parathyroid hormone	Homo sapiens	77-80
23926179-0	2013	Vitamin D increases plasma renin activity independently of plasma Ca2+ via hypovolemia and beta-adrenergic activity.	Vitamin D	0-9	renin	Homo sapiens	27-32
24075759-13	2013	Both platelet activation inhibitor-1 and tissue plasminogen activator levels fell significantly in the vitamin D group relative to placebo at 8 weeks.	Vitamin D	103-112	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	25-36
24076648-5	2013	On the basis of these data, it is suggested that appropriate doses of active vitamin D and phosphate are to be selected according to the data of serum PTH, ALP and the amount of urinary excretion of calcium.	Vitamin D	77-86	parathyroid hormone	Homo sapiens	151-154
23789983-2	2013	Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF-I serum values in population-based cohorts of healthy subjects.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	144-149
23789983-3	2013	The modulation of IGF-I and IGFBP-3 concentrations by vitamin D may impact recombinant human (rh) GH dosing for the treatment of GHD.	Vitamin D	54-63	insulin like growth factor 1	Homo sapiens	18-23
23381556-2	2013	Some studies have reported associations between vitamin D pathway genes such as VDR, GC and CYP27B1 with body mass index (BMI) and waist circumference (WC); however, the findings have been inconsistent.	Vitamin D	48-57	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	92-99
23377775-4	2013	We investigated the association between vitamin D status and 5-year changes in urine albumin creatinine ratio (UACR) and parathyroid hormone (PTH).	Vitamin D	40-49	parathyroid hormone	Homo sapiens	121-140
23935129-2	2013	Thus, in large genome-wide association studies, it has been shown that single nucleotide polymorphisms (SNPs) in the vitamin D binding protein (DBP), as well as in enzymes related to activation or degradation of vitamin D and its metabolites, are as important for the serum 25(OH)D level as the effect of season.	Vitamin D	117-126	D-box binding PAR bZIP transcription factor	Homo sapiens	144-147
24170964-1	2013	Elevated serum alkaline phosphatase (ALP) is a screening marker for the diagnosis of vitamin D deficiency, which may fail to be diagnosed if serum ALP is not elevated.	Vitamin D	85-94	alkaline phosphatase, placental	Homo sapiens	15-35
24170964-1	2013	Elevated serum alkaline phosphatase (ALP) is a screening marker for the diagnosis of vitamin D deficiency, which may fail to be diagnosed if serum ALP is not elevated.	Vitamin D	85-94	alkaline phosphatase, placental	Homo sapiens	37-40
24170964-7	2013	Serum intact PTH and urine PEA evaluations were helpful for diagnosing vitamin D deficiency and hypophosphatasia carrier status, respectively.	Vitamin D	71-80	parathyroid hormone	Homo sapiens	13-16
24290086-0	2013	Defining a cutoff point for vitamin D deficiency based on insulin resistance in children.	Vitamin D	28-37	insulin	Homo sapiens	58-65
24290086-2	2013	Low levels of serum 25-hydroxy vitamin D [25(OH)D], as a marker of vitamin D deficiency, have been linked to a wide field of health problems, including metabolic diseases such as insulin resistance, type 1 and type 2 DM.	Vitamin D	31-40	insulin	Homo sapiens	179-186
23566943-2	2013	Vitamin D (VD) may be implicated in obesity and its complications such as insulin resistance, hypertension, and low-grade inflammation.	Vitamin D	0-9	insulin	Homo sapiens	74-81
24251166-4	2013	Vitamin D dependent rickets (VDDR) is of two types: Type I is due to defective renal tubular 25-hydroxyvitamin D 1-alpha hydroxylase and type II is due to end-organ resistance to active metabolite of vitamin D.	Vitamin D	103-112	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-27
24251166-4	2013	Vitamin D dependent rickets (VDDR) is of two types: Type I is due to defective renal tubular 25-hydroxyvitamin D 1-alpha hydroxylase and type II is due to end-organ resistance to active metabolite of vitamin D.	Vitamin D	103-112	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-33
24251176-5	2013	It consists of calcium sensing receptor (CaSR) on intestinal brush border, which senses calcium in intestinal cells and vitamin D system in intestinal cells.	Vitamin D	120-129	calcium sensing receptor	Homo sapiens	41-45
24251176-6	2013	CaSR dampens the generation of active vitamin D metabolite in intestinal cells and decrease active transcellular calcium transport.	Vitamin D	38-47	calcium sensing receptor	Homo sapiens	0-4
24073266-0	2013	Changes in the calcium-parathyroid hormone-vitamin d axis and prognosis for critically ill patients: a prospective observational study.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	15-42
23553608-8	2013	These studies provide a molecular basis for recent epidemiological associations between vitamin D status, body weight and insulin resistance which may have relevance for prevention or treatment of metabolic syndrome and obesity.	Vitamin D	88-97	insulin	Homo sapiens	122-129
24090586-1	2013	Few interventional studies have reported a positive effect of native vitamin D supplementation on intermediary parameters of insulin resistance, of cardiovascular risk and on major cardiovascular events and mortality.	Vitamin D	69-78	insulin	Homo sapiens	125-132
24358684-6	2013	Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production.	Vitamin D	0-9	interleukin 6	Homo sapiens	19-23
24109497-2	2013	Additionally, vitamin D deficiency causes an increase in parathyroid hormone, which increases insulin resistance and is associated with diabetes, hypertension, inflammation, and increased cardiovascular risk.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	57-76
24109497-2	2013	Additionally, vitamin D deficiency causes an increase in parathyroid hormone, which increases insulin resistance and is associated with diabetes, hypertension, inflammation, and increased cardiovascular risk.	Vitamin D	14-23	insulin	Homo sapiens	94-101
23885046-1	2013	BACKGROUND: Secondary hyperparathyroidism, which is defined by a high concentration of intact parathyroid hormone when circulating 25-hydroxyvitamin D [25(OH)D] is low, is a functional indicator of vitamin D insufficiency and a sign of impaired calcium metabolism.	Vitamin D	141-150	parathyroid hormone	Homo sapiens	94-113
24422136-0	2013	Sclerostin could regulate vitamin D metabolism and calcium excretion.	Vitamin D	26-35	sclerostin	Homo sapiens	0-10
23974111-1	2013	By means of an unbiased, automated fluorescence microscopy-based screen, we identified the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent enhancers of the differentiation of HL-60 acute myeloid leukemia (AML) cells exposed to suboptimal concentrations of vitamin A (all-trans retinoic acid, ATRA) or vitamin D (1alpha,25-hydroxycholecalciferol, VD).	Vitamin D	338-347	epidermal growth factor receptor	Homo sapiens	91-123
23974111-1	2013	By means of an unbiased, automated fluorescence microscopy-based screen, we identified the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent enhancers of the differentiation of HL-60 acute myeloid leukemia (AML) cells exposed to suboptimal concentrations of vitamin A (all-trans retinoic acid, ATRA) or vitamin D (1alpha,25-hydroxycholecalciferol, VD).	Vitamin D	338-347	epidermal growth factor receptor	Homo sapiens	125-129
24019880-1	2013	The mitochondrial enzyme 25-hydroxyvitamin D 1alpha-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D).	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	89-96
24073221-0	2013	Influence of vitamin D-related gene polymorphisms (CYP27B and VDR) on the response to interferon/ribavirin therapy in chronic hepatitis C. BACKGROUND AND AIMS: Vitamin D exerts immunomodulatory effects on the host response against infection with hepatitis C virus (HCV).	Vitamin D	13-22	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	51-57
30754191-4	2013	Recent studies suggested that insulin resistance in PCOS is associated with decreased vitamin D levels that could not be explained by obesity alone.	Vitamin D	86-95	insulin	Homo sapiens	30-37
23856074-0	2013	Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.	Vitamin D	32-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	136-141
23721405-1	2013	Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the pancreas.	Vitamin D	75-84	insulin	Homo sapiens	119-126
30754191-5	2013	Vitamin D treatment may therefore have positive effects on insulin sensitivity and perhaps also hyperandrogenemia in patients with PCOS.	Vitamin D	0-9	insulin	Homo sapiens	59-66
23754696-3	2013	In addition, vitamin D influences muscle metabolism by genomic and non-genomic actions, including stimulation of the insulin-like-growth-factor 1 (IGF1), a major regulator of muscle trophism.	Vitamin D	13-22	insulin like growth factor 1	Homo sapiens	117-145
23927858-9	2013	A significant positive association between vitamin D level and gait speed was found only in those with high CRP in stratified analyses.	Vitamin D	43-52	C-reactive protein	Homo sapiens	108-111
23927858-11	2013	CONCLUSION: These findings provide evidence of a potential joint effect of vitamin D and CRP on gait speed, suggesting that evaluation and correction of vitamin D levels may be especially important in individuals with high CRP levels.	Vitamin D	153-162	C-reactive protein	Homo sapiens	89-92
23302127-2	2013	Vitamin D is involved in the pathogenesis of pancreatic beta-cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM.	Vitamin D	0-9	insulin	Homo sapiens	79-86
23302127-5	2013	More double-blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.	Vitamin D	77-86	insulin	Homo sapiens	106-113
23754696-3	2013	In addition, vitamin D influences muscle metabolism by genomic and non-genomic actions, including stimulation of the insulin-like-growth-factor 1 (IGF1), a major regulator of muscle trophism.	Vitamin D	13-22	insulin like growth factor 1	Homo sapiens	147-151
23884390-0	2013	Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women.	Vitamin D	0-9	insulin	Homo sapiens	77-84
23643404-1	2013	OBJECTIVE: Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes.	Vitamin D	49-58	insulin	Homo sapiens	86-93
24371490-2	2013	New roles of vitamin D have emerged recently especially in the prevention of cardiovascular disease, cancer and insulin resistance.	Vitamin D	13-22	insulin	Homo sapiens	112-119
23643404-10	2013	CONCLUSIONS: Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype.	Vitamin D	45-54	insulin	Homo sapiens	77-84
23787544-2	2013	Active vitamin D can suppress parathyroid hormone (PTH), but may raise serum calcium and phosphate concentrations.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	30-49
23927947-0	2013	Parathyroid hormone has an important role in blood pressure regulation in vitamin D-insufficient individuals.	Vitamin D	74-83	parathyroid hormone	Homo sapiens	0-19
23945218-0	2013	Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	120-123
24160191-5	2013	The majority of the analyzed intervention studies reported beneficial effects of increased calcium and vitamin D ingestion on insulin sensitivity improvement and T2DM prevention.	Vitamin D	103-112	insulin	Homo sapiens	126-133
24034921-8	2013	1,25-(OH)2D3 inhibits the expression of IL-13 and IL-17, suggesting that vitamin D intake may provide protective effects in the development of atopy-predisposing immune responses in early life.	Vitamin D	73-82	interleukin 13	Homo sapiens	40-45
23965431-0	2013	Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease.	Vitamin D	21-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-75
23945218-10	2013	Low vitamin D levels were associated with obesity, being born outside Sweden and high PTH levels.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	86-89
22924597-9	2013	The pro-inflammatory markers IL-6 and hs-CRP also decreased considerably with higher vitamin D levels (P &lt; 0 001).	Vitamin D	85-94	interleukin 6	Homo sapiens	29-33
23895820-2	2013	Vitamin D may inhibit renin transcription and lower PRA.	Vitamin D	0-9	renin	Homo sapiens	22-27
23809192-12	2013	In conclusion, we arrived at the following: 1) severe vitamin D deficiency is common in DM patients and it is associated with secondary hyperparathyroidism; 2) primary hyperparathyroidism, though rare, may occur; 3) increased adiposity in DM may be a risk factor for hypovitaminosis D; and 4) high serum PTH levels may indicate a muscle impairment, at least in DM1.	Vitamin D	54-63	parathyroid hormone	Homo sapiens	304-307
23770983-6	2013	CONCLUSION: Serum vitamin D level is significantly and independently associated with insulin resistance and beta-cell function in a healthy Chinese female population.	Vitamin D	18-27	insulin	Homo sapiens	85-92
23930605-7	2013	RESULTS: Data suggests that vitamin D has an inhibitory effect on the RhoA/ROCK pathway, along with cyclooxygenase-2 expression and prostaglandin E2 production in BPH stromal cells.	Vitamin D	28-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	100-116
23930605-10	2013	Pre-clinical trials have shown vitamin D to not only decrease BPH cell and prostate cell proliferation alone, but also when induced by known growth promoting molecules such as IL-8, Des (1-3) IGF-1, testosterone and dihydrotestosterone.	Vitamin D	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
23930605-10	2013	Pre-clinical trials have shown vitamin D to not only decrease BPH cell and prostate cell proliferation alone, but also when induced by known growth promoting molecules such as IL-8, Des (1-3) IGF-1, testosterone and dihydrotestosterone.	Vitamin D	31-40	insulin like growth factor 1	Homo sapiens	192-197
23736055-13	2013	This is 1 of 6 enzymes involved in metabolizing vitamin D to 25OHD.	Vitamin D	48-57	25OHD	Bos taurus	61-66
23619147-13	2013	CONCLUSIONS: miR-627 mediates tumor-suppressive epigenetic activities of vitamin D on colorectal cancer cells and xenograft tumors in mice.	Vitamin D	73-82	microRNA 627	Homo sapiens	13-20
23619147-15	2013	Reagents designed to target JMJD1A or its messenger RNA, or increase the function of miR-627, might have the same antitumor activities of vitamin D without the hypercalcemic side effects.	Vitamin D	138-147	microRNA 627	Homo sapiens	85-92
23719723-5	2013	The purpose of this review is to highlight how maternal vitamin D deficiency, and its effects in upregulating the fetal renin-angiotensin system and altering cardiomyocyte growth in the fetal heart, has the potential to program long-term vulnerability to cardiovascular disease.	Vitamin D	56-65	renin	Homo sapiens	120-125
23557869-6	2013	In vitro experiments on vitamin D pre-treated PBMCs evaluated TNFalpha production by ELISA in culture supernatants.	Vitamin D	24-33	tumor necrosis factor	Homo sapiens	62-70
23030238-9	2013	Downregulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included.	Vitamin D	84-93	interleukin 6	Homo sapiens	18-22
23799341-11	2013	Vitamin D level was also independently associated with high-sensitivity C reactive protein (beta = -0.143, P = 0.047).	Vitamin D	0-9	C-reactive protein	Homo sapiens	72-90
23030238-10	2013	LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment.	Vitamin D	98-107	interleukin 6	Homo sapiens	12-16
23679998-7	2013	It consists of calcium sensing receptor (CaSR) on intestinal brush border, which senses calcium in intestinal cells and vitamin D system in intestinal cells.	Vitamin D	120-129	calcium sensing receptor	Homo sapiens	41-45
23679998-8	2013	CaSR dampens the generation of active vitamin D metabolite in intestinal cells and decrease active transcellular calcium transport.	Vitamin D	38-47	calcium sensing receptor	Homo sapiens	0-4
23923049-0	2013	Primary vitamin D target genes allow a categorization of possible benefits of vitamin D3 supplementation.	Vitamin D	8-17	iodothyronine deiodinase 3	Homo sapiens	86-88
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	137-163
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	165-171
23420502-1	2013	BACKGROUND: Vitamin D insufficiency is related to erythropoietin resistance in chronic kidney disease (CKD).	Vitamin D	12-21	erythropoietin	Homo sapiens	50-64
23889806-2	2013	Animal studies suggest that these pleiotropic effects of vitamin D may be mediated by suppression of renin.	Vitamin D	57-66	renin	Homo sapiens	101-106
23886009-11	2013	CONCLUSION: Vitamin D deficiency is very common among hospitalized adult tuberculosis patients in Uganda especially in patients with hypoalbuminemia, anemia, HIV co-infected patients with CD4 count &lt;200cells/mm3 and hypocalcemia corrected for serum albumin levels.	Vitamin D	12-21	CD4 molecule	Homo sapiens	188-191
23770363-0	2013	Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23875738-0	2013	Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: a pilot study.	Vitamin D	0-9	toll like receptor 2	Homo sapiens	46-66
23875738-7	2013	RESULTS: In participants whose vitamin D level was &gt;100 nmol/L post supplementation (n=11), TLR2 expression on PBMCs increased significantly, with no change noted in TLR4 or CD86 expression.	Vitamin D	31-40	toll like receptor 2	Homo sapiens	95-99
23623574-8	2013	In participants with and without vitamin D deficiency, annual age-standardized incidences were 0.92% (95% CI, 0.56%-1.30%) and 0.59% (95% CI, 0.51%-0.68%), respectively, for eGFR &lt;60 mL/min/1.72 m2 and 1.50% (95% CI, 1.06%-1.95%) and 0.66% (95% CI, 0.56%-0.76%), respectively, for albuminuria.	Vitamin D	33-42	CD59 molecule (CD59 blood group)	Homo sapiens	189-194
23829946-0	2013	DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: an European multicentre, randomised trial - study protocol.	Vitamin D	6-15	DNMT1-associated long intergenic non-coding RNA	Homo sapiens	0-4
23924693-9	2013	We conclude that vitamin D deficiency is a potential risk factor for obesity and development of insulin resistance leading to diabetes type 2.	Vitamin D	17-26	insulin	Homo sapiens	96-103
23748358-1	2013	BACKGROUND: There is growing evidence to support an important role for vitamin D and related hormones, parathyroid hormone and fibroblast growth factor 23 (FGF23), on cardiac remodeling in chronic kidney disease.	Vitamin D	71-80	parathyroid hormone	Homo sapiens	103-122
23611977-0	2013	Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.	Vitamin D	83-92	insulin	Homo sapiens	113-122
23611977-1	2013	We sought to determine if autologous umbilical cord blood (UCB) infusion followed by 1 year of supplementation with vitamin D and docosahexaenoic acid (DHA) can preserve C-peptide in children with type 1 diabetes.	Vitamin D	116-125	insulin	Homo sapiens	170-179
23669253-11	2013	Vitamin D-treated rats showed a significant decrease in plasma CK level, phosphorylation of AMPK, p38, ERK1/2, IKK, and IkappaB, and gene expression of IL-6 and TNF-alpha.	Vitamin D	0-9	interleukin 6	Rattus norvegicus	152-156
23669253-11	2013	Vitamin D-treated rats showed a significant decrease in plasma CK level, phosphorylation of AMPK, p38, ERK1/2, IKK, and IkappaB, and gene expression of IL-6 and TNF-alpha.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	161-170
23889483-5	2013	In addition, septic patients have decreased vitamin D binding-protein (DBP) levels which further exacerbate the vitamin D deficiency.	Vitamin D	44-53	D-box binding PAR bZIP transcription factor	Homo sapiens	71-74
23889483-7	2013	Vitamin D treatment in vitro has also been demonstrated to modulate levels of the systemic inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as inhibit the lipopolysaccharide (LPS)-induced activation and vasodilation of vascular endothelium.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	123-150
23677931-6	2013	At E14 BP was significantly elevated in vitamin D-deficient pregnant mice relative to vitamin D-sufficient mice for both systolic BP (124.89 +- 2.28 vs 105.34 +- 3.61 mm Hg, P &lt; .001) and mean arterial pressure (115.33 +- 1.93 vs 89.33 +- 5.02 mm Hg, P &lt; .001).	Vitamin D	40-49	skull morphology 21	Mus musculus	3-6
23889483-7	2013	Vitamin D treatment in vitro has also been demonstrated to modulate levels of the systemic inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as inhibit the lipopolysaccharide (LPS)-induced activation and vasodilation of vascular endothelium.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	152-161
23677931-9	2013	Histological analysis of E14 placentas from vitamin D-deficient mice showed decreased vascular diameter within the labyrinth region.	Vitamin D	44-53	skull morphology 21	Mus musculus	25-28
23889483-7	2013	Vitamin D treatment in vitro has also been demonstrated to modulate levels of the systemic inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as inhibit the lipopolysaccharide (LPS)-induced activation and vasodilation of vascular endothelium.	Vitamin D	0-9	interleukin 6	Homo sapiens	167-180
23677931-10	2013	E14 and E18 fetuses from vitamin D-deficient mice were larger than those from vitamin D-sufficient mothers.	Vitamin D	25-34	skull morphology 21	Mus musculus	0-3
23329150-9	2013	CONCLUSION: In elderly patients with AS, we observed an association between AS progression and vitamin D, iPTH and CTX/osteocalcin ratio and their respective influence varied according to the vitamin D status.	Vitamin D	192-201	bone gamma-carboxyglutamate protein	Homo sapiens	119-130
23889483-7	2013	Vitamin D treatment in vitro has also been demonstrated to modulate levels of the systemic inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as inhibit the lipopolysaccharide (LPS)-induced activation and vasodilation of vascular endothelium.	Vitamin D	0-9	interleukin 6	Homo sapiens	182-186
23274116-2	2013	In order to further explore this class of pharmacologically important vitamin D compounds we have decided to synthesize analogs characterized by the presence of two A-ring exocyclic methylene groups attached to C-2 and C-10.	Vitamin D	70-79	homeobox C10	Homo sapiens	219-223
23877860-0	2013	LPS and HIV gp120 modulate monocyte/macrophage CYP27B1 and CYP24A1 expression leading to vitamin D consumption and hypovitaminosis D in HIV-infected individuals.	Vitamin D	89-98	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	47-54
23877860-3	2013	PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS).	Vitamin D	99-108	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	150-157
23595236-8	2013	The results showed that the mRNA and protein levels of VDUP1 were significantly upregulated by vitamin D.	Vitamin D	95-104	thioredoxin interacting protein	Homo sapiens	55-60
23595236-12	2013	Based on these data, it can be concluded that vitamin D increases TSLP expression in 16-HBE cells through the VDUP1 pathway, which suggests a novel mechanism by which vitamin D alters immune function in the lungs.	Vitamin D	46-55	thioredoxin interacting protein	Homo sapiens	110-115
23595236-12	2013	Based on these data, it can be concluded that vitamin D increases TSLP expression in 16-HBE cells through the VDUP1 pathway, which suggests a novel mechanism by which vitamin D alters immune function in the lungs.	Vitamin D	167-176	thioredoxin interacting protein	Homo sapiens	110-115
23653431-2	2013	OBJECTIVE: The objective was to evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum PTH and bone resorption markers as compared with isocaloric and isoprotein dairy products in elderly women.	Vitamin D	79-88	parathyroid hormone	Homo sapiens	147-150
23209039-2	2013	Patients with chronic kidney disease (CKD) are likely to have low levels of 25(OH)D, and recent observations have linked suboptimal vitamin D status with adverse cardiovascular outcomes, inflammation, insulin resistance, and the rate of progression of renal insufficiency.	Vitamin D	132-141	insulin	Homo sapiens	201-208
22981997-5	2013	We and others have also shown that increased vitamin D activity in mature osteoblasts by increasing levels of VDR or CYP27B1 leads to improved bone mineral volume using two separate transgenic mouse models.	Vitamin D	45-54	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	117-124
23511701-6	2013	RESULTS: Baseline serum IL-6 showed significant negative correlations with lumbar BMD and handgrip strength (r = -0.458, P = 0.01, and left hand; r = -0.387, P = 0.03, respectively), whereas serum 25-hydroxy vitamin D level was 13.97 (5.65) ng/mL, compatible with vitamin D insufficiency and inversely correlated with PTH level (r = -0.481, P = 0.005).	Vitamin D	208-217	interleukin 6	Homo sapiens	24-28
23511701-6	2013	RESULTS: Baseline serum IL-6 showed significant negative correlations with lumbar BMD and handgrip strength (r = -0.458, P = 0.01, and left hand; r = -0.387, P = 0.03, respectively), whereas serum 25-hydroxy vitamin D level was 13.97 (5.65) ng/mL, compatible with vitamin D insufficiency and inversely correlated with PTH level (r = -0.481, P = 0.005).	Vitamin D	264-273	interleukin 6	Homo sapiens	24-28
23468534-0	2013	Renal anaemia and EPO hyporesponsiveness associated with vitamin D deficiency: the potential role of inflammation.	Vitamin D	57-66	erythropoietin	Homo sapiens	18-21
23468534-14	2013	Given the key role of inflammation in the response to EPO, the therapeutic use of agents with anti-cytokines properties, such as vitamin D and paricalcitol, may provide benefit in the prevention/treatment of ESA hyporesponsiveness.	Vitamin D	129-138	erythropoietin	Homo sapiens	54-57
22985909-2	2013	This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4.	Vitamin D	71-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	50-56
22985909-2	2013	This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4.	Vitamin D	99-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	112-118
22985909-4	2013	The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency.	Vitamin D	130-139	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	36-42
22989482-1	2013	Human marrow stromal cells (hMSCs) are targets of 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D3] action to promote their differentiation to osteoblasts, but they also participate in vitamin D metabolism by converting 25-dihydroxyvitamin D3 [25(OH)D3] to 1alpha,25(OH)2D3 by 1alpha-hydroxylase (CYP27B1).	Vitamin D	69-78	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	295-302
22995734-9	2013	We present our recently published data showing two single nucleotide polymorphisms in vitamin D catabolic enzyme CYP24A1 associated with higher risk of estrogen ER-negative risk in AA than in EA women.	Vitamin D	86-95	estrogen receptor 1	Homo sapiens	161-163
24306155-10	2013	CONCLUSION: We suggest that low 25(OH)D occurs commonly in obese adolescents with NAFLD and we demonstrated an association between insufficient vitamin D status and low insulin sensitivity in obese adolescents with NAFLD.	Vitamin D	144-153	insulin	Homo sapiens	169-176
23826346-0	2013	Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease.	Vitamin D	22-31	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	86-95
23864319-7	2013	Vitamin D supplementation results in favorable effects with a reduced risk for falls and also improvements of insulin sensitivity.	Vitamin D	0-9	insulin	Homo sapiens	110-117
23826346-3	2013	We assessed the effects of vitamin D deficiency throughout life (from conception until adulthood) on the severity of ovalbumin-induced allergic airway disease in vitamin D-replete and -deficient BALB/c mice using this model.	Vitamin D	27-36	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	117-126
23566834-3	2013	Analysis of the 5.0Kb upstream sequence of the pre-let-7a-2 showed that one vitamin D response element (VDRE) is located in -2066/-2042bp of pre-let-7a-2.	Vitamin D	76-85	microRNA let-7a-2	Homo sapiens	51-59
23180681-2	2013	To further elucidate this association, we examined the influence of vitamin D-binding protein (DBP), the primary transporter of vitamin D compounds in the circulation.	Vitamin D	68-77	D-box binding PAR bZIP transcription factor	Homo sapiens	95-98
23180681-7	2013	Our data suggest that the primary vitamin D carrier protein, DBP, modulates the impact of vitamin D status on prostate cancer.	Vitamin D	34-43	D-box binding PAR bZIP transcription factor	Homo sapiens	61-64
23566834-3	2013	Analysis of the 5.0Kb upstream sequence of the pre-let-7a-2 showed that one vitamin D response element (VDRE) is located in -2066/-2042bp of pre-let-7a-2.	Vitamin D	76-85	microRNA let-7a-2	Homo sapiens	145-153
23180681-7	2013	Our data suggest that the primary vitamin D carrier protein, DBP, modulates the impact of vitamin D status on prostate cancer.	Vitamin D	90-99	D-box binding PAR bZIP transcription factor	Homo sapiens	61-64
23576577-2	2013	Novel interactions between vitamin D and the renin-angiotensin axis.	Vitamin D	27-36	renin	Homo sapiens	45-50
23675750-1	2013	We explored the relationship between vitamin D levels and insulin resistance (IR) among 1082 nondiabetic (754 HIV-infected) women enrolled in the Women"s Interagency HIV study (WIHS), a large and well-established cohort of HIV infected and uninfected women in the US.	Vitamin D	37-46	insulin	Homo sapiens	58-65
23675750-8	2013	We found a marginally significant association between vitamin D insufficiency and insulin resistance among nondiabetic HIV-infected WIHS women.	Vitamin D	54-63	insulin	Homo sapiens	82-89
23576577-3	2013	Focus on "The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system".	Vitamin D	32-41	renin	Homo sapiens	139-144
23585425-10	2013	The acute colitis model induced in combination with a vitamin D-deficient diet resulted in increased morbidity, receptor downregulation, inflammatory marker expression, and Snail and Snail2 upregulation.	Vitamin D	54-63	snail family zinc finger 2	Mus musculus	183-189
24032264-3	2013	The beneficial effects of vitamin D supplementation on insulin resistance, ovarian follicles maturation, ovulation and menstrual regularity were confirmed.	Vitamin D	26-35	insulin	Homo sapiens	55-62
23746304-1	2013	There has been substantial recent interest in using vitamin D to improve insulin sensitivity and preventing/delaying diabetes in those at risk.	Vitamin D	52-61	insulin	Homo sapiens	73-80
24396662-0	2013	Adiposity in the Relationship between Serum Vitamin D Level and Insulin Resistance in Middle-Aged and Elderly Korean Adults: The Korea National Health and Nutrition Examination Survey 2008.	Vitamin D	44-53	insulin	Homo sapiens	64-71
24396662-1	2013	BACKGROUND: The role of adiposity in the relationship between serum vitamin D levels and insulin resistance has not yet been fully studied.	Vitamin D	68-77	insulin	Homo sapiens	89-96
24396662-2	2013	This aim of this study is to clarify the role of adiposity in the relationship between serum vitamin D level and insulin resistance among middle-aged and elderly Korean adults.	Vitamin D	93-102	insulin	Homo sapiens	113-120
24396662-6	2013	In the stratified analyses, 25(OH) vitamin D was found to be negatively associated with fasting insulin and homeostasis model assessment estimate of insulin resistance (HOMA-IR) in participants with BMIs &gt;=25 kg/m(2) (P=0.003 for both insulin and HOMR-IR) but was not found to be associated in those with BMIs &lt;23 kg/m(2).	Vitamin D	35-44	insulin	Homo sapiens	96-103
24396662-6	2013	In the stratified analyses, 25(OH) vitamin D was found to be negatively associated with fasting insulin and homeostasis model assessment estimate of insulin resistance (HOMA-IR) in participants with BMIs &gt;=25 kg/m(2) (P=0.003 for both insulin and HOMR-IR) but was not found to be associated in those with BMIs &lt;23 kg/m(2).	Vitamin D	35-44	insulin	Homo sapiens	149-156
24396662-6	2013	In the stratified analyses, 25(OH) vitamin D was found to be negatively associated with fasting insulin and homeostasis model assessment estimate of insulin resistance (HOMA-IR) in participants with BMIs &gt;=25 kg/m(2) (P=0.003 for both insulin and HOMR-IR) but was not found to be associated in those with BMIs &lt;23 kg/m(2).	Vitamin D	35-44	insulin	Homo sapiens	149-156
24396662-9	2013	In addition, the association of vitamin D with insulin resistance in middle-aged and elderly Korean adults was stronger when it was stratified by BMI than when abdominal obesity status.	Vitamin D	32-41	insulin	Homo sapiens	47-54
23065434-1	2013	OBJECTIVE: Associations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported.	Vitamin D	43-52	insulin	Homo sapiens	87-94
23169318-3	2013	We systemically evaluated the association of 89 tagging and candidate-based GSVs in six major vitamin D metabolism pathway genes (VDR, GC, CYP24A1, CYP27A1, CYP27B1 and CYP2R1) and the circulating serum vitamin D level with overall survival (OS) and second primary cancer (SPC) in 522 Stages I-II radiation-treated patients with HNC.	Vitamin D	94-103	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	157-164
23322512-6	2013	In the in vivo study, samples of subcutaneous AT from obese subjects obtained before and after treatment with 7,000 IU of vitamin D daily or placebo in a randomized controlled trial were stimulated with IL-1beta.	Vitamin D	122-131	interleukin 1 beta	Homo sapiens	203-211
23212742-2	2013	Human CYP24A1, CYP3A4, and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse drug response.	Vitamin D	79-88	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	15-21
23139068-3	2013	The osteoblastic OC protein is encoded by the bone gamma-carbossiglutamate gene whose transcription is principally regulated by the Runx2/Cbfa1 regulatory element and stimulated by vitamin D(3) through a steroid-responsive enhancer sequence.	Vitamin D	181-190	bone gamma-carboxyglutamate protein	Homo sapiens	17-19
23858619-0	2013	Vitamin D action: lessons from VDR and Cyp27b1 null mice.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	39-46
23858619-2	2013	Inactivation of the vitamin D receptor (VDR) or the enzymes metabolizing its ligand (especially Cyp27bl) in mice has clearly demonstrated that the active form of vitamin D [1,25(OH)2D] is essential to stimulate calcium absorption in the gut during normal/low calcium intake, and as a consequence, that 1,25(OH)2D is required to maintain normal serum calcium, bone and growth plate homeostasis.	Vitamin D	20-29	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	96-101
23674796-0	2013	A novel approach localizes the association of vitamin D status with insulin resistance to one region of the 25-hydroxyvitamin D continuum.	Vitamin D	46-55	insulin	Homo sapiens	68-75
23674796-1	2013	Vitamin D status has been implicated in insulin resistance, type 2 diabetes mellitus, and hypertension, but the range of vitamin D status values over which the association can be found is unknown.	Vitamin D	0-9	insulin	Homo sapiens	40-47
23639611-6	2013	Ca2+ or vitamin D treatment induced CaSR expression with a concurrent up-regulation of TGFbeta receptor expression.	Vitamin D	8-17	calcium sensing receptor	Homo sapiens	36-40
23639611-6	2013	Ca2+ or vitamin D treatment induced CaSR expression with a concurrent up-regulation of TGFbeta receptor expression.	Vitamin D	8-17	transforming growth factor beta 1	Homo sapiens	87-94
23289765-3	2013	Given that IFN-gamma activates a vitamin D-dependent antimicrobial response, we focused on induction of the key components of this pathway.	Vitamin D	33-42	interferon gamma	Homo sapiens	11-20
23289765-5	2013	The activation of the vitamin D pathway by CD40L and IFN-gamma results in up-regulated expression of the antimicrobial peptides, cathelicidin and DEFB4, as well as induction of autophagy.	Vitamin D	22-31	CD40 ligand	Homo sapiens	43-48
23289765-5	2013	The activation of the vitamin D pathway by CD40L and IFN-gamma results in up-regulated expression of the antimicrobial peptides, cathelicidin and DEFB4, as well as induction of autophagy.	Vitamin D	22-31	interferon gamma	Homo sapiens	53-62
23289765-5	2013	The activation of the vitamin D pathway by CD40L and IFN-gamma results in up-regulated expression of the antimicrobial peptides, cathelicidin and DEFB4, as well as induction of autophagy.	Vitamin D	22-31	defensin beta 4A	Homo sapiens	146-151
23289765-7	2013	Our data suggest that at least two parallel T-cell-mediated mechanisms, CD40L and IFN-gamma, activate the vitamin D-dependent antimicrobial pathway and trigger antimicrobial activity against intracellular M. tuberculosis, thereby contributing to human host defence against intracellular infection.	Vitamin D	106-115	CD40 ligand	Homo sapiens	72-77
23289765-7	2013	Our data suggest that at least two parallel T-cell-mediated mechanisms, CD40L and IFN-gamma, activate the vitamin D-dependent antimicrobial pathway and trigger antimicrobial activity against intracellular M. tuberculosis, thereby contributing to human host defence against intracellular infection.	Vitamin D	106-115	interferon gamma	Homo sapiens	82-91
23618499-6	2013	CONCLUSION: Maternal vitamin D deficiency is associated with low PlGF levels and increased preeclampsia risk.	Vitamin D	21-30	placental growth factor	Homo sapiens	65-69
23452379-7	2013	CONCLUSIONS: Our study in 4978 British Whites provides further support that APOA5 genotype modifies the association between vitamin D metabolites and HDL cholesterol.	Vitamin D	124-133	apolipoprotein A5	Homo sapiens	76-81
23509103-2	2013	The threshold of 25OHD needed to maximally suppress intact PTH has been suggested as a marker of optimal vitamin D status.	Vitamin D	105-114	parathyroid hormone	Homo sapiens	59-62
23212742-2	2013	Human CYP24A1, CYP3A4, and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse drug response.	Vitamin D	79-88	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	27-34
22366195-11	2013	CONCLUSION: In women with postmenopausal osteoporosis, the number of circulating CD15-/AP+/CD34- cells is significantly associated with increased aortic calcifications, that appear to be correlated also with reduced 25(OH)vitamin D levels.	Vitamin D	222-231	fucosyltransferase 4	Homo sapiens	81-85
23303458-6	2013	Vitamin D, another epidermal signal, enhanced TGF-beta1-mediated beta-catenin induction and promoted the expression of multiple epithelial genes by LCs.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	46-55
22366195-11	2013	CONCLUSION: In women with postmenopausal osteoporosis, the number of circulating CD15-/AP+/CD34- cells is significantly associated with increased aortic calcifications, that appear to be correlated also with reduced 25(OH)vitamin D levels.	Vitamin D	222-231	CD34 molecule	Homo sapiens	91-95
22366195-9	2013	In regression analyses, the log-transformed number of CD15-/AP+/CD34- cells was associated with the presence (OR = 6.45, 95% CI 1.03-40.1, p = 0.04) and severity (beta = 0.43, p &lt; 0.001) of AAC, independent of age, 25(OH)vitamin D, calcium and other potential confounders.	Vitamin D	224-233	fucosyltransferase 4	Homo sapiens	54-58
23184178-4	2013	During recent years, a number of studies have shown that PTH replacement therapy (PTH-RT) may maintain calcium levels within the normal range, while the need for calcium and vitamin D supplements is reduced.	Vitamin D	174-183	parathyroid hormone	Homo sapiens	57-60
22366195-9	2013	In regression analyses, the log-transformed number of CD15-/AP+/CD34- cells was associated with the presence (OR = 6.45, 95% CI 1.03-40.1, p = 0.04) and severity (beta = 0.43, p &lt; 0.001) of AAC, independent of age, 25(OH)vitamin D, calcium and other potential confounders.	Vitamin D	224-233	CD34 molecule	Homo sapiens	64-68
23184178-4	2013	During recent years, a number of studies have shown that PTH replacement therapy (PTH-RT) may maintain calcium levels within the normal range, while the need for calcium and vitamin D supplements is reduced.	Vitamin D	174-183	parathyroid hormone	Homo sapiens	82-85
23596520-1	2013	INTRODUCTION: Though inconsistent, a number of studies have shown an association between vitamin D (25(OH)D) status, parathyroid hormone (PTH) and the metabolic syndrome (Met S).	Vitamin D	89-98	parathyroid hormone	Homo sapiens	117-136
23423976-0	2013	CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.	Vitamin D	43-52	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	12-19
22968764-2	2013	We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status.	Vitamin D	88-97	insulin	Homo sapiens	65-72
23748365-4	2013	We have hypothesized that vitamin D treatment may alter the levels of sRAGE and EN-RAGE in HD patients.	Vitamin D	26-35	S100 calcium binding protein A12	Homo sapiens	80-87
23614044-0	2013	Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis.	Vitamin D	40-49	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	66-73
23614044-2	2013	OBJECTIVE: Polymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases.	Vitamin D	32-41	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	58-65
23549173-0	2013	Evaluation of the potential therapeutic role of a new generation of vitamin D analog, MART-10, in human pancreatic cancer cells in vitro and in vivo.	Vitamin D	68-77	septin 4	Homo sapiens	86-90
23596520-1	2013	INTRODUCTION: Though inconsistent, a number of studies have shown an association between vitamin D (25(OH)D) status, parathyroid hormone (PTH) and the metabolic syndrome (Met S).	Vitamin D	89-98	parathyroid hormone	Homo sapiens	138-141
23407306-0	2013	Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial.	Vitamin D	11-20	insulin	Homo sapiens	44-51
23407306-9	2013	CONCLUSION: The correction of poor vitamin D status through dietary supplementation may be an effective addition to the standard treatment of obesity and its associated insulin resistance.	Vitamin D	35-44	insulin	Homo sapiens	169-176
23435685-3	2013	Vitamin D (vitD) and analogs have been shown to suppress TNF-alpha-induced IL-1alpha in human keratinocytes (KCs).	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	57-66
23221508-1	2013	BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] is a marker of nutritional status; however, chronic kidney disease (CKD) results in alterations in vitamin D metabolism, including the loss of vitamin D-binding proteins and alterations in CYP27B1 and CYP24 enzymes that metabolize 25(OH)D. This study was designed to determine the predictors of responsiveness to correction of vitamin D deficiency with oral vitamin D2 (ergocalciferol) in adults.	Vitamin D	22-31	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	231-238
23083515-0	2013	Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
23083515-10	2013	CONCLUSION: Vitamin D may potentially inhibit the periodontal inflammation induced by P. gingivalis partly by decreasing the IL-8 expression in hPDLCs.	Vitamin D	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
23109222-7	2013	Vitamin D status was an independent predictor of GH-IGF-I axis and supplementation with vitamin D decreased IGF-I/IGFBP-3 ratio in subjects without severe obesity.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	52-57
23556437-1	2013	BACKGROUND: It is not known whether genetic variation in the vitamin D binding protein (DBP) influences 25-hydroxyvitamin D levels [25(OH)D] after vitamin D supplementation.	Vitamin D	61-70	D-box binding PAR bZIP transcription factor	Homo sapiens	88-91
23264189-0	2013	Role of vitamin D in the development of insulin resistance and type 2 diabetes.	Vitamin D	8-17	insulin	Homo sapiens	40-47
23264189-2	2013	Experimental data have shown that vitamin D is important for glucose induced insulin secretion, improves insulin resistance, and exerts anti-inflammatory actions.	Vitamin D	34-43	insulin	Homo sapiens	77-84
23264189-3	2013	Epidemiological studies have largely documented that a poor vitamin D status is associated with higher risk of insulin resistance and type 2 diabetes.	Vitamin D	60-69	insulin	Homo sapiens	111-118
23109222-2	2013	Our hypothesis was that there is a relation between GH, IGF-I, and 25(OH)D; and that vitamin D supplementation may have an effect on the levels of GH, IGF-I, and IGF-I/IGFBP-3 ratio.	Vitamin D	85-94	insulin like growth factor 1	Homo sapiens	151-156
23109222-2	2013	Our hypothesis was that there is a relation between GH, IGF-I, and 25(OH)D; and that vitamin D supplementation may have an effect on the levels of GH, IGF-I, and IGF-I/IGFBP-3 ratio.	Vitamin D	85-94	insulin like growth factor 1	Homo sapiens	151-156
23109222-7	2013	Vitamin D status was an independent predictor of GH-IGF-I axis and supplementation with vitamin D decreased IGF-I/IGFBP-3 ratio in subjects without severe obesity.	Vitamin D	88-97	insulin like growth factor 1	Homo sapiens	108-113
23109222-9	2013	Adverse effects of GH-IGF-I axis on glucose metabolism and the development of metabolic syndrome may be in part associated with the changes in vitamin D status.	Vitamin D	143-152	insulin like growth factor 1	Homo sapiens	22-27
23247634-7	2013	ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1.	Vitamin D	19-28	mitogen-activated protein kinase 3	Homo sapiens	0-4
23703334-3	2013	Experimental studies demonstrated several antihypertensive and vascular protective effects of vitamin D, such as suppression of the renin angiotensin aldosterone system, beneficial modulation of classic cardiovascular risk factors, and anti-atherosclerotic properties including improvements of endothelial function.	Vitamin D	94-103	renin	Homo sapiens	132-137
23350644-0	2013	The effect of different doses of vitamin D supplementation on insulin resistance during pregnancy.	Vitamin D	33-42	insulin	Homo sapiens	62-69
23350644-1	2013	Low serum vitamin D levels are correlated with insulin resistance during pregnancy.	Vitamin D	10-19	insulin	Homo sapiens	47-54
23350644-2	2013	We have assessed the effects of different doses of vitamin D on insulin resistance during pregnancy.	Vitamin D	51-60	insulin	Homo sapiens	64-71
23350644-10	2013	This study has shown that supplementation of pregnant women with 50 000 IU vitamin D every 2 weeks improved insulin resistance significantly.	Vitamin D	75-84	insulin	Homo sapiens	108-115
26236422-0	2013	BMI but Not Race Contributes to Vitamin D-Parathyroid Hormone Axis in Peripubertal Girls.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	42-61
23247634-0	2013	Vitamin D protects human endothelial cells from H2O2 oxidant injury through the Mek/Erk-Sirt1 axis activation.	Vitamin D	0-9	mitogen-activated protein kinase kinase 7	Homo sapiens	80-83
23247634-7	2013	ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1.	Vitamin D	19-28	mitogen-activated protein kinase 3	Homo sapiens	98-102
23247634-0	2013	Vitamin D protects human endothelial cells from H2O2 oxidant injury through the Mek/Erk-Sirt1 axis activation.	Vitamin D	0-9	mitogen-activated protein kinase 1	Homo sapiens	84-87
23247634-7	2013	ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1.	Vitamin D	19-28	mitogen-activated protein kinase 3	Homo sapiens	118-124
23247634-4	2013	Vitamin D protected endothelial cells against H2O2 oxidative stress counteracting the superoxide anion generation, the apoptosis and blocking the extrinsic caspase cascade by positively controlling phospho-active ERKs level.	Vitamin D	0-9	mitogen-activated protein kinase 3	Homo sapiens	213-217
23247634-9	2013	Thus, vitamin D significantly reduced the endothelial malfunction and damage caused by oxidative stress, through the activation of MEKs/ERKs/SirT-1 axis.	Vitamin D	6-15	mitogen-activated protein kinase 3	Homo sapiens	136-140
23247634-5	2013	MEKs/ERKs inhibitor U0126 reverted the vitamin D anti-oxidant effects.	Vitamin D	39-48	mitogen-activated protein kinase 3	Homo sapiens	5-9
23645099-0	2013	Effect of acute and chronic vitamin D administration on systemic renin angiotensin system in essential hypertensives and controls.	Vitamin D	28-37	renin	Homo sapiens	65-70
23436065-9	2013	The combination of vitamin A and vitamin D markedly enhanced the expression of Bax and reduced the expression of Cyclin D1 by real time-PCR and western blot assay.	Vitamin D	33-42	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
23602243-0	2013	Association of racial disparities in the prevalence of insulin resistance with racial disparities in vitamin D levels: National Health and Nutrition Examination Survey (2001-2006).	Vitamin D	101-110	insulin	Homo sapiens	55-62
23307906-12	2013	Larger studies with stronger study designs are needed to clarify potential drug-vitamin D interactions, especially for drugs metabolized by cytochrome P450 3A4 (CYP3A4).	Vitamin D	80-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	140-159
23307906-12	2013	Larger studies with stronger study designs are needed to clarify potential drug-vitamin D interactions, especially for drugs metabolized by cytochrome P450 3A4 (CYP3A4).	Vitamin D	80-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	161-167
23154302-0	2013	Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection.	Vitamin D	44-53	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	134-138
23712984-12	2013	In summary, these findings provide initial evidence for a relationship between OCN and body fat measures that is dependent on energy metabolism and vitamin D status among obese adolescents.	Vitamin D	148-157	bone gamma-carboxyglutamate protein	Homo sapiens	79-82
23602243-1	2013	We tested the hypothesis that racial differences in vitamin D levels are associated with racial disparities in insulin resistance between blacks and whites.	Vitamin D	52-61	insulin	Homo sapiens	111-118
26105863-12	2013	CONCLUSION: Short-term vitamin D depletion aggravated hypertension and end-organ damage in a rat model of angiotensin II-induced hypertension.	Vitamin D	23-32	angiotensinogen	Rattus norvegicus	106-120
23449998-3	2013	IFN-gamma and its downstream vitamin D-dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against the pathogen Mycobacterium leprae in vitro.	Vitamin D	29-38	interferon alpha 1	Homo sapiens	0-3
26105863-3	2013	OBJECTIVE: To investigate the impact of vitamin D in a transgenic rat model of angiotensin II-mediated hypertensive organ failure.	Vitamin D	40-49	angiotensinogen	Rattus norvegicus	79-93
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	interleukin 1 beta	Homo sapiens	108-116
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	interleukin 13	Homo sapiens	118-123
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	tumor necrosis factor	Homo sapiens	125-134
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	26-34
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	interleukin 6	Homo sapiens	50-54
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-91
23012315-7	2013	Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta.	Vitamin D	29-38	interleukin 1 beta	Homo sapiens	147-155
23449998-5	2013	The IFN-gamma-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-beta and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.	Vitamin D	33-42	interferon gamma	Homo sapiens	4-13
23322908-4	2013	Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-beta peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression.	Vitamin D	0-9	calcium sensing receptor	Homo sapiens	54-78
23497703-0	2013	Commentary on: effect of vitamin D on insulin resistance and anthropometric parameters in type 2 diabetes; a randomized double-blind clinical trial.	Vitamin D	25-34	insulin	Homo sapiens	38-45
23322908-4	2013	Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-beta peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression.	Vitamin D	0-9	amyloid beta precursor protein	Homo sapiens	101-113
22968355-0	2013	Do low preoperative vitamin D levels reduce the accuracy of quick parathyroid hormone in predicting postthyroidectomy hypocalcemia?	Vitamin D	20-29	parathyroid hormone	Homo sapiens	66-85
23444327-1	2013	An association has previously been reported between susceptibility to multiple sclerosis and the rare mutant alleles of the CYP27B1 gene responsible for autosomal recessive vitamin D-dependent rickets type 1 (VDDR1).	Vitamin D	173-182	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	124-131
23483640-2	2013	Rare CYP27B1 mutations cause autosomal recessive vitamin D-dependent rickets type 1, and it has recently been reported that heterozygous CYP27B1 mutations are associated with increased MS susceptibility and lower active vitamin D levels.	Vitamin D	49-58	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	5-12
23483640-2	2013	Rare CYP27B1 mutations cause autosomal recessive vitamin D-dependent rickets type 1, and it has recently been reported that heterozygous CYP27B1 mutations are associated with increased MS susceptibility and lower active vitamin D levels.	Vitamin D	220-229	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	137-144
23299053-4	2013	RECENT FINDINGS: Several animal studies corroborate the strong effect of vitamin D on the renin-angiotensin-aldosterone axis.	Vitamin D	73-82	renin	Homo sapiens	90-95
23393179-9	2013	In multiple regression analyses after adjustment for age, gender, hemodialysis duration, calcium, phosphate, vitamin D use, and phosphate binder use, intact PTH was associated significantly with body weight (beta = .190; P &lt; .0001), body mass index (beta = .177; P &lt; .0001), fat mass (beta = .142; P &lt; .0005), and lean mass (beta = .192; P &lt; .01).	Vitamin D	109-118	parathyroid hormone	Homo sapiens	157-160
23386641-3	2013	OBJECTIVES: The objective of the study was to measure the effect of vitamin D3 on serum 25OHD and serum PTH in older African American women with vitamin D insufficiency and the serum 25OHD 20 ng/mL or less (&lt;50 nmol/L).	Vitamin D	68-77	parathyroid hormone	Homo sapiens	104-107
22995334-1	2013	1alpha-Hydroxylase (CYP27B1), the enzyme responsible for the synthesis of the biologically active form of vitamin D (1,25(OH)(2)D(3)), is expressed in the skin.	Vitamin D	106-115	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	20-27
23524629-6	2013	Serum vitamin D levels showed a positive correlation with age (p&lt;0.05), HDL-cholesterol (p&lt;0.05), and adiponectin (p&lt;0.05) levels.	Vitamin D	6-15	adiponectin, C1Q and collagen domain containing	Homo sapiens	108-119
23524629-8	2013	In addition, even after adjusting for factors that may affect the cardiovascular index (age, sex, body mass index, smoking, and alcohol intake), serum vitamin D levels showed a significant correlation with triglyceride (p&lt;0.05), HDL-cholesterol (p&lt;0.05), and adiponectin (p&lt;0.05) levels.	Vitamin D	151-160	adiponectin, C1Q and collagen domain containing	Homo sapiens	265-276
23445921-0	2013	Vitamin D status and muscle function in children with neurofibromatosis type 1 (NF1).	Vitamin D	0-9	neurofibromin 1	Homo sapiens	54-78
23445921-0	2013	Vitamin D status and muscle function in children with neurofibromatosis type 1 (NF1).	Vitamin D	0-9	neurofibromin 1	Homo sapiens	80-83
23445921-1	2013	OBJECTIVES: The aim of this cross-sectional study was to assess the vitamin D status and muscle function in children with NF1 compared with their unaffected siblings.	Vitamin D	68-77	neurofibromin 1	Homo sapiens	122-125
23020803-1	2013	Vitamin D is a fat-soluble precursor of the circulating 25-hydroxyvitamin D3 (25(OH)D3)which can be converted by the 1alpha-hydroxylase (1alpha(OH)ase) enzyme into the bioactive hormonal metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), generally known to promote bone mineralization through its ability to enhance calcium absorption from the gut.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	137-150
23169676-6	2013	There are also suggestions that vitamin D alters muscle metabolism, specifically its sensitivity to insulin, which is a pertinent feature in the pathophysiology of insulin resistance and type 2 diabetes.	Vitamin D	32-41	insulin	Homo sapiens	100-107
23465502-2	2013	Renal vitamin D metabolism requires filtration and tubular reabsorption of 25-hydroxyvitamin D and is regulated by parathyroid hormone, fibroblast growth factor-23, and 1,25-dihydroxyvitamin D.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	115-134
23483715-7	2013	Some of the genes involved in vitamin D metabolism (e.g. CYP27B1) also play a significant role.	Vitamin D	30-39	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	57-64
23443033-0	2013	The effect of vitamin D on insulin resistance in patients with type 2 diabetes.	Vitamin D	14-23	insulin	Homo sapiens	27-34
23443033-2	2013	Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity.	Vitamin D	40-49	insulin	Homo sapiens	121-128
23443033-2	2013	Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity.	Vitamin D	40-49	insulin	Homo sapiens	143-150
23443033-3	2013	This study evaluates the effects of vitamin D supplementation on insulin resistance in T2DM.	Vitamin D	36-45	insulin	Homo sapiens	65-72
23443033-12	2013	CONCLUSION: Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM.	Vitamin D	111-120	insulin	Homo sapiens	67-74
23443033-12	2013	CONCLUSION: Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM.	Vitamin D	111-120	insulin	Homo sapiens	176-183
23443033-12	2013	CONCLUSION: Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM.	Vitamin D	137-146	insulin	Homo sapiens	67-74
23443033-12	2013	CONCLUSION: Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM.	Vitamin D	137-146	insulin	Homo sapiens	176-183
23033239-1	2013	This double-blind, randomized, control study in subjects with prediabetes and hypovitaminosis D evaluated whether high doses of vitamin D for 1 year affected insulin secretion, insulin sensitivity, and the development of diabetes.	Vitamin D	128-137	insulin	Homo sapiens	158-165
23095316-0	2013	Vitamin D insufficiency may impair CD4 recovery among Women"s Interagency HIV Study participants with advanced disease on HAART.	Vitamin D	0-9	CD4 molecule	Homo sapiens	35-38
23095316-1	2013	BACKGROUND: Recent studies in HIV-infected men report an association between low vitamin D (25OH-D) and CD4 recovery on HAART.	Vitamin D	81-90	CD4 molecule	Homo sapiens	104-107
23095316-8	2013	In adjusted analyses, at 24 months after HAART, insufficient vitamin D level (OR 0.20, 95% CI 0.05-0.83) was associated with decreased odds of CD4 recovery.	Vitamin D	61-70	CD4 molecule	Homo sapiens	143-146
23095316-11	2013	CONCLUSION: Vitamin D insufficiency is associated with diminished late CD4 recovery after HAART initiation among US women living with advanced HIV.	Vitamin D	12-21	CD4 molecule	Homo sapiens	71-74
23095316-12	2013	The mechanism of this association on late CD4 recovery may be late vitamin D-associated production of naive CD4 cells during immune reconstitution.	Vitamin D	67-76	CD4 molecule	Homo sapiens	42-45
23095316-12	2013	The mechanism of this association on late CD4 recovery may be late vitamin D-associated production of naive CD4 cells during immune reconstitution.	Vitamin D	67-76	CD4 molecule	Homo sapiens	108-111
23210615-5	2013	Supplementation of cell culture medium with vitamin D(3) induces the osteocalcin expression of osteoblasts.	Vitamin D	44-53	bone gamma-carboxyglutamate protein	Homo sapiens	69-80
23210615-9	2013	Supplementation of the cell culture medium with both vitamin D(3) and a cocktail of osteogenic factors is recommended to produce an osteoblast phenotype that secretes osteocalcin, expresses alkaline phosphatase and deposits calcium.	Vitamin D	53-62	bone gamma-carboxyglutamate protein	Homo sapiens	167-178
23232064-1	2013	BACKGROUND: Vitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance, hallmarks of type 2 diabetes mellitus.	Vitamin D	12-21	insulin	Homo sapiens	66-73
22763025-4	2013	Specifically, influence of vitamin D on the renin-angiotensin-aldosterone system, inflammatory response, and urinary albumin excretion could explain the relevant impact of vitamin D status on diabetic nephropathy.	Vitamin D	27-36	renin	Homo sapiens	44-49
23169676-6	2013	There are also suggestions that vitamin D alters muscle metabolism, specifically its sensitivity to insulin, which is a pertinent feature in the pathophysiology of insulin resistance and type 2 diabetes.	Vitamin D	32-41	insulin	Homo sapiens	164-171
22560354-0	2013	Osteocalcin and vitamin D status are inversely associated with homeostatic model assessment of insulin resistance in Canadian Aboriginal and white women: the First Nations Bone Health Study.	Vitamin D	16-25	insulin	Homo sapiens	95-102
22728278-6	2013	Vitamin D and miRNAs regulate and complement IGF-1 mediated function and neuroprotective efficacy via modulation of IGF-1 availability and neural stem cell and immune cell proliferation, differentiation and secretions.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	45-50
22728278-6	2013	Vitamin D and miRNAs regulate and complement IGF-1 mediated function and neuroprotective efficacy via modulation of IGF-1 availability and neural stem cell and immune cell proliferation, differentiation and secretions.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	116-121
23064465-1	2013	PURPOSE: A prospective multicentre cohort study was conducted to determine the prevalence of hypovitaminosis D in adult critically ill patients, to characterize alterations in the parathyroid hormone (PTH)-vitamin D-calcium axis and to explore associations between hypovitaminosis D and adverse clinical outcomes.	Vitamin D	206-215	parathyroid hormone	Homo sapiens	180-199
23064465-1	2013	PURPOSE: A prospective multicentre cohort study was conducted to determine the prevalence of hypovitaminosis D in adult critically ill patients, to characterize alterations in the parathyroid hormone (PTH)-vitamin D-calcium axis and to explore associations between hypovitaminosis D and adverse clinical outcomes.	Vitamin D	206-215	parathyroid hormone	Homo sapiens	201-204
23064465-7	2013	Secondary hyperparathyroidism (PTH &gt; 7 pmol/L) was observed in 37.5 % of hypocalcaemic and 32.5 % of vitamin D insufficient/deficient patients, and was associated with higher SAPS-II [43 (31.3-60) vs. 36 (30-43), p = 0.03].	Vitamin D	104-113	parathyroid hormone	Homo sapiens	31-34
23334593-9	2013	Increased VDR expression in MS NAWM and inflammatory cytokine-induced amplified expression of VDR and CYP27B1 in chronic active MS lesions suggest increased sensitivity to vitamin D in NAWM and a possible endogenous role for vitamin D metabolism in the suppression of active MS lesions.	Vitamin D	172-181	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	102-109
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	coagulation factor II, thrombin	Homo sapiens	145-153
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	interleukin 1 beta	Homo sapiens	192-200
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	tumor necrosis factor	Homo sapiens	205-214
23295467-2	2013	Recently the action of CYP11A1 on vitamin D(3) was shown to produce biologically active 20S-hydroxyvitamin D [20(OH)D(3)] and 20,23(OH)(2)D(3), 20,22(OH)(2)D(3), and 17,20,23(OH)(3)D(3).	Vitamin D	34-43	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	23-30
23130887-0	2013	The ratio of parathyroid hormone to vitamin D is a determinant of cardiovascular risk and insulin sensitivity in adolescent girls.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	13-32
23364486-12	2013	Log 25-OH-vitamin D values, serum phosphorus levels, vitamin D supplementation (p=0.07), season (p=0.10) and eGFR were correlated with log PTH values in the patients with CKD.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	139-142
23364486-9	2013	Among the participants with a normal eGFR, the LAPACQ score, vitamin D supplementation, season, log PTH value and eGFR were correlated with log 25-OH-vitamin D levels.	Vitamin D	150-159	parathyroid hormone	Homo sapiens	100-103
23364486-9	2013	Among the participants with a normal eGFR, the LAPACQ score, vitamin D supplementation, season, log PTH value and eGFR were correlated with log 25-OH-vitamin D levels.	Vitamin D	150-159	epidermal growth factor receptor	Homo sapiens	114-118
23130887-0	2013	The ratio of parathyroid hormone to vitamin D is a determinant of cardiovascular risk and insulin sensitivity in adolescent girls.	Vitamin D	36-45	insulin	Homo sapiens	90-97
23085504-0	2013	Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase.	Vitamin D	0-9	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	85-89
23337117-5	2013	Importantly, depletion or inhibition of CTSL with vitamin D or specific inhibitors stabilized 53BP1 and increased genomic instability in response to radiation and poly(adenosine diphosphate-ribose) polymerase inhibitors, compromising proliferation.	Vitamin D	50-59	cathepsin L	Homo sapiens	40-44
23331510-2	2013	BACKGROUND: Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host.	Vitamin D	12-21	interferon gamma	Homo sapiens	127-132
23331510-9	2013	Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline "Deficient" 25-hydroxyvitamin D serum levels (p 0.021).	Vitamin D	0-9	interferon gamma	Homo sapiens	70-75
23594726-6	2013	In the cinacalcet group, the expression of CaSR was increased significantly compared with that in the conventional group (1.83 +- 0.14 vs. 0.87 +- 0.15, p &lt; 0.001), even though the proportion of patients using vitamin D sterols and the mean administered dose of calcitriol equivalents were not significantly different between the two groups.	Vitamin D	213-222	calcium sensing receptor	Homo sapiens	43-47
23635517-8	2013	CONCLUSIONS: Baseline vitamin D status and serum phosphorous are independent determinants of the longitudinal variation in PTH and FGF23, respectively.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	123-126
23642201-1	2013	Our understanding of the mechanism of action of vitamin D has been broadened by the discovery of the extrarenal 1alpha-hydroxylase (CYP27B1) in various vitamin D target tissues around the body and the implications of this for the putative paracrine actions of 1alpha,25-dihydroxyvitamin D3.	Vitamin D	48-57	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	132-139
23642201-1	2013	Our understanding of the mechanism of action of vitamin D has been broadened by the discovery of the extrarenal 1alpha-hydroxylase (CYP27B1) in various vitamin D target tissues around the body and the implications of this for the putative paracrine actions of 1alpha,25-dihydroxyvitamin D3.	Vitamin D	152-161	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	132-139
23085504-0	2013	Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase.	Vitamin D	0-9	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	99-106
23966755-2	2013	Active vitamin D and phosphate are administered to correct hypophosphatemia and elevation of ALP.	Vitamin D	7-16	alkaline phosphatase, placental	Homo sapiens	93-96
23509804-0	2013	Possible role of hyperinsulinemia and insulin resistance in lower vitamin D levels in overweight and obese patients.	Vitamin D	66-75	insulin	Homo sapiens	22-29
22594967-3	2013	Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system.	Vitamin D	0-9	renin	Homo sapiens	35-40
23724632-9	2013	There was a significant relationship between serum levels of vitamin D with ionized Ca, PTH, ALP, type of clothing, and egg consumption, while no significant relationship was found between serum levels of vitamin D with age, residency, menstruation status, skin color, sun light exposure, body mass index, waist to hip ratio, exercise, physical activity, fish consumption, and polymorphisms in exon 9 of VDR gene.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	88-91
24494038-5	2013	Main products of CYP11A1-mediated metabolism on vitamin D are non-calcemic and non-toxic at relatively high doses and serve as partial agonists on the vitamin D receptor.	Vitamin D	48-57	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	17-24
23170821-6	2013	Vitamin D also exerts its effect on HIV through nongenomic factors, i.e., ultraviolet radiation exposure, matrix metalloproteinase, heme oxygenase-1, the prostaglandins, cyclooxygenase-2, and oxidative stress.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	170-186
23427793-1	2013	The vitamin D binding protein (DBP) is the major plasma carrier for vitamin D and its metabolites, but it is also an actin scavenger, and is the precursor to the immunomodulatory protein, Gc-MAF.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
24080758-0	2013	Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children?	Vitamin D	13-22	parathyroid hormone	Homo sapiens	23-42
22972177-6	2013	Thus, vitamin D deficient Saudi children and adults with normal levels of 1,25-(OH)2D also had normal circulating calcium and PTH.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	126-129
24381426-3	2013	Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk.	Vitamin D	18-27	insulin	Homo sapiens	47-54
24381426-11	2013	The insulin resistance was more in vitamin D deficiency state.	Vitamin D	35-44	insulin	Homo sapiens	4-11
24381426-12	2013	Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.	Vitamin D	6-15	insulin	Homo sapiens	75-82
23606841-0	2013	Vitamin d deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	99-106
23606841-13	2013	The insulin resistance of the obese subjects who were vitamin D deficient and insufficient did not statistically differ from those with vitamin D sufficiency.	Vitamin D	54-63	insulin	Homo sapiens	4-11
23467803-2	2013	Identification of modifiable risk factors such as vitamin D (Vit D) deficiency could help develop novel strategies for the prevention and/or treatment of UFs.	Vitamin D	50-59	vitrin	Homo sapiens	61-64
23983686-4	2013	We evaluated the association of metabolic risk factors with both adiponectin and vitamin D levels and that between adiponectin and vitamin D levels.	Vitamin D	131-140	adiponectin, C1Q and collagen domain containing	Homo sapiens	115-126
23624519-0	2013	A new mechanism for amyloid-beta induction of iNOS: vitamin D-VDR pathway disruption.	Vitamin D	52-61	nitric oxide synthase 2	Homo sapiens	46-50
23624519-2	2013	Here, we investigated iNOS expression in cortical neurons following amyloid-beta (Abeta) treatment, vitamin D treatment, Abeta combined with vitamin D treatment, and vitamin D signaling disruption via silencing of nuclear (vitamin D receptor-VDR) or membrane vitamin D (1,25-MARRS) receptors.	Vitamin D	141-150	nitric oxide synthase 2	Homo sapiens	22-26
23624519-2	2013	Here, we investigated iNOS expression in cortical neurons following amyloid-beta (Abeta) treatment, vitamin D treatment, Abeta combined with vitamin D treatment, and vitamin D signaling disruption via silencing of nuclear (vitamin D receptor-VDR) or membrane vitamin D (1,25-MARRS) receptors.	Vitamin D	141-150	nitric oxide synthase 2	Homo sapiens	22-26
23624519-2	2013	Here, we investigated iNOS expression in cortical neurons following amyloid-beta (Abeta) treatment, vitamin D treatment, Abeta combined with vitamin D treatment, and vitamin D signaling disruption via silencing of nuclear (vitamin D receptor-VDR) or membrane vitamin D (1,25-MARRS) receptors.	Vitamin D	141-150	nitric oxide synthase 2	Homo sapiens	22-26
23624519-4	2013	Vitamin D prevented Abeta-induced cytotoxicity and iNOS upregulation in cortical neurons.	Vitamin D	0-9	amyloid beta precursor protein	Homo sapiens	20-25
23624519-4	2013	Vitamin D prevented Abeta-induced cytotoxicity and iNOS upregulation in cortical neurons.	Vitamin D	0-9	nitric oxide synthase 2	Homo sapiens	51-55
23624519-5	2013	Our silencing experiments suggest that vitamin D regulates iNOS via VDR, not 1,25-MARRS, in cortical neurons.	Vitamin D	39-48	nitric oxide synthase 2	Homo sapiens	59-63
23624519-7	2013	While our previous work demonstrates that Abeta pathology includes VDR suppression, our present work demonstrates that Abeta induces iNOS and that this effect is mediated via disruption of the vitamin D-VDR pathway.	Vitamin D	193-202	amyloid beta precursor protein	Homo sapiens	119-124
23624519-7	2013	While our previous work demonstrates that Abeta pathology includes VDR suppression, our present work demonstrates that Abeta induces iNOS and that this effect is mediated via disruption of the vitamin D-VDR pathway.	Vitamin D	193-202	nitric oxide synthase 2	Homo sapiens	133-137
23277041-6	2013	We suggest that the negative cardiovascular effects of low vitamin D in postmenopausal women could be improved by a combined treatment of vitamin D and sex steroids acting through endothelium-dependent and/or -independent mechanisms, resulting in the generation of nitric oxide and calcitonin gene-related peptide (CGRP).	Vitamin D	138-147	calcitonin related polypeptide alpha	Homo sapiens	282-313
23277041-6	2013	We suggest that the negative cardiovascular effects of low vitamin D in postmenopausal women could be improved by a combined treatment of vitamin D and sex steroids acting through endothelium-dependent and/or -independent mechanisms, resulting in the generation of nitric oxide and calcitonin gene-related peptide (CGRP).	Vitamin D	138-147	calcitonin related polypeptide alpha	Homo sapiens	315-319
23875809-6	2013	RESULTS: Improvement of vitamin D status in DD and CDD groups, compared to PD, resulted in a significant increase in Apo A1 (mean changes 0.22 +- 0.38, 0.20 +- 0.27 and 0.01 +- 0.35 g/L, respectively, p = 0.047) and a significant decrease in serum Lp(a) (mean changes -0.08 +- 0.30, -0.08 +- 0.31, and 0.14 +- 0.25 mumol/L, respectively, p = 0.011).	Vitamin D	24-33	apolipoprotein A1	Homo sapiens	117-123
23144471-13	2013	CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	220-223
24081327-10	2013	Major allele homozygotes with low vitamin D status may be at increased risk of insulin resistance.	Vitamin D	34-43	insulin	Homo sapiens	79-86
28197433-8	2013	The reason may be due to excessive intake of calcium and Vitamin D analogues, which may suppress parathyroid hormone secretion.	Vitamin D	57-66	parathyroid hormone	Homo sapiens	97-116
23281135-6	2013	Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet.	Vitamin D	146-155	chemokine (C-X-C motif) ligand 1	Mus musculus	77-82
23281135-6	2013	Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet.	Vitamin D	146-155	chemokine (C-X-C motif) ligand 2	Mus musculus	83-88
23281135-6	2013	Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet.	Vitamin D	191-200	chemokine (C-X-C motif) ligand 1	Mus musculus	77-82
23900423-0	2013	The effects of oral vitamin D on insulin resistance in pre-diabetic patients.	Vitamin D	20-29	insulin	Homo sapiens	33-40
23729614-3	2013	The authors describe here a case of type II vitamin D-dependent rickets (VDDR type II) in a 10-year-old Indian girl who presented with diabetic ketoacidosis (DKA).	Vitamin D	44-53	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	73-77
23900423-2	2013	A previous study in our center showed that intramuscular vitamin D decreases insulin sensitivity in pre-diabetic patients.	Vitamin D	57-66	insulin	Homo sapiens	77-84
23900423-3	2013	We investigated the role of oral vitamin D on the insulin sensitivity index and insulin resistance in pre-diabetic patients.	Vitamin D	33-42	insulin	Homo sapiens	50-57
23900423-12	2013	A randomized double-blind study with a longer duration of treatment is suggested to investigate the effect of vitamin D on insulin resistance.	Vitamin D	110-119	insulin	Homo sapiens	123-130
23942553-3	2013	Hyperphosphatemia through induction of vascular calcifications and decreased active vitamin D production leading to activation of the renin angiotensin system (RAS) along with defects in innate immunity are purported to be the proximate cause of CKD-MBD-associated mortality in CKD.	Vitamin D	84-93	renin	Homo sapiens	134-139
22895369-5	2013	In addition, serum vitamin D levels were inversely related to total cholesterol, triglycerides, fasting glucose, and insulin.	Vitamin D	19-28	insulin	Homo sapiens	117-124
23043683-1	2013	AIM: To assess the impact of vitamin D supplementation (cholecalciferol) on the insulin sensitivity and metabolic health of patients with chronic kidney disease (CKD).	Vitamin D	29-38	insulin	Homo sapiens	80-87
23256106-1	2012	The aim of this study was to assess vitamin D (vit.D) levels in patients with primary antiphospholipid syndrome (PAPS), the association between hypovitaminosis D and clinical manifestations, and the effect of vit.D supplementation on serum levels.	Vitamin D	36-45	vitrin	Homo sapiens	47-50
24029861-0	2013	A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D.	Vitamin D	175-184	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	95-102
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	10-19	COPI coat complex subunit beta 2	Homo sapiens	107-112
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	55-64	COPI coat complex subunit beta 2	Homo sapiens	107-112
23326564-0	2013	Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.	Vitamin D	41-50	signal transducer and activator of transcription 3	Homo sapiens	15-20
23326564-4	2013	METHODS AND FINDINGS: The treatment with Gemini vitamin D BXL0124 decreased CD44 protein level, suppressed STAT3 signaling, and inhibited invasion and proliferation of MCF10DCIS cells.	Vitamin D	48-57	signal transducer and activator of transcription 3	Homo sapiens	107-112
23326564-12	2013	It also suggests that repression of CD44-STAT3 signaling is a key molecular mechanism in the inhibition of breast cancer invasion by the Gemini vitamin D analog BXL0124.	Vitamin D	144-153	signal transducer and activator of transcription 3	Homo sapiens	41-46
24455835-6	2013	Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients.	Vitamin D	16-25	calcium sensing receptor	Homo sapiens	245-269
24455835-6	2013	Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients.	Vitamin D	16-25	calcium sensing receptor	Homo sapiens	271-275
24375245-0	2013	Vitamin D status and its seasonal variations and association with parathyroid hormone concentration in healthy women in Riga.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	66-85
23160809-0	2012	Vitamin D supplementation in multiple sclerosis patients in 2012: hype or reality as an adjunctive therapy?	Vitamin D	0-9	FIC domain protein adenylyltransferase	Homo sapiens	66-70
23441390-7	2012	Regarding biomarkers, parathyroid hormone and haptoglobin were found to be related with the odds of having vitamin D deficiency (OR = 1.11, 95% CI: 1.05-1.16; OR = 1.02, 95% CI: 1.00-1.03, respectively) as compared to the sufficient levels.	Vitamin D	107-116	haptoglobin	Homo sapiens	46-57
22358381-6	2012	Within Group I, vitamin D levels showed a negative correlation with IgE and IL-4 levels, and a positive correlation with IFN-gamma (p &lt; 0.05).	Vitamin D	16-25	immunoglobulin heavy constant epsilon	Homo sapiens	68-71
22925537-1	2012	Insufficient vitamin D status has been linked to autoimmune diseases, cancer and metabolic disorders, like obesity and insulin resistance.	Vitamin D	13-22	insulin	Homo sapiens	119-126
22925537-9	2012	One year intervention with vitamin D decreased serum IL-6 levels; however hs-CRP levels were significantly increased.	Vitamin D	27-36	interleukin 6	Homo sapiens	53-57
22358381-1	2012	We aimed to study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-gamma, which play an important role in the immune response of patients with allergic rhinitis and/or nasal polyps, and determine the correlation between Th1/Th2 cell balance and 1alpha,25-dihydroxyvitamin D(3), an active metabolite of vitamin D.	Vitamin D	294-303	interferon gamma	Homo sapiens	93-102
22358381-6	2012	Within Group I, vitamin D levels showed a negative correlation with IgE and IL-4 levels, and a positive correlation with IFN-gamma (p &lt; 0.05).	Vitamin D	16-25	interleukin 4	Homo sapiens	76-80
22358381-6	2012	Within Group I, vitamin D levels showed a negative correlation with IgE and IL-4 levels, and a positive correlation with IFN-gamma (p &lt; 0.05).	Vitamin D	16-25	interferon gamma	Homo sapiens	121-130
23045480-0	2012	Interleukin 13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide 18/LL-37 in bronchial epithelial cells.	Vitamin D	33-42	interleukin 13	Homo sapiens	0-14
23093338-1	2012	BACKGROUND/OBJECTIVES: The association between vitamin D status and insulin resistance (IR) has been less studied among Asians, and it remains elusive whether calcium could modify such an association.	Vitamin D	47-56	insulin	Homo sapiens	68-75
23045480-0	2012	Interleukin 13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide 18/LL-37 in bronchial epithelial cells.	Vitamin D	33-42	cathelicidin antimicrobial peptide	Homo sapiens	114-119
23045480-2	2012	Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requires local conversion of 25(OH)-vitamin D(3) (25D(3)) into its bioactive metabolite, 1,25(OH)(2)-vitamin D(3) (1,25D(3)), by CYP27B1.	Vitamin D	124-133	cathelicidin antimicrobial peptide	Homo sapiens	106-112
23045480-2	2012	Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requires local conversion of 25(OH)-vitamin D(3) (25D(3)) into its bioactive metabolite, 1,25(OH)(2)-vitamin D(3) (1,25D(3)), by CYP27B1.	Vitamin D	124-133	cathelicidin antimicrobial peptide	Homo sapiens	114-119
23045480-10	2012	In conclusion, we demonstrate that IL-13 induces vitamin D-dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1.	Vitamin D	49-58	interleukin 13	Homo sapiens	35-40
23045480-10	2012	In conclusion, we demonstrate that IL-13 induces vitamin D-dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1.	Vitamin D	49-58	cathelicidin antimicrobial peptide	Homo sapiens	69-75
23045480-10	2012	In conclusion, we demonstrate that IL-13 induces vitamin D-dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1.	Vitamin D	49-58	cathelicidin antimicrobial peptide	Homo sapiens	76-81
23045480-10	2012	In conclusion, we demonstrate that IL-13 induces vitamin D-dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1.	Vitamin D	49-58	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	120-127
22926646-2	2012	Here, we demonstrate that maxacalcitol (22-oxacalcitriol (OCT)), an analog of active vitamin D, protects the kidney from TIF by suppressing the autoinduction of transforming growth factor-beta1 (TGF-beta1).	Vitamin D	85-94	transforming growth factor, beta 1	Rattus norvegicus	161-193
23111651-0	2012	Effect of vitamin D replacement on insulin sensitivity in subjects with vitamin D deficiency.	Vitamin D	10-19	insulin	Homo sapiens	35-42
23111651-0	2012	Effect of vitamin D replacement on insulin sensitivity in subjects with vitamin D deficiency.	Vitamin D	72-81	insulin	Homo sapiens	35-42
23111651-1	2012	BACKGROUND AND OBJECTIVE: Low vitamin D levels correlate with measures of insulin resistance and prevalence of diabetes mellitus, but there are limited and conflicting data on changes in insulin resistance after vitamin D replacement.	Vitamin D	30-39	insulin	Homo sapiens	74-81
23111651-1	2012	BACKGROUND AND OBJECTIVE: Low vitamin D levels correlate with measures of insulin resistance and prevalence of diabetes mellitus, but there are limited and conflicting data on changes in insulin resistance after vitamin D replacement.	Vitamin D	212-221	insulin	Homo sapiens	187-194
23111651-2	2012	The objective of the current study was to examine whether vitamin D replacement improves insulin sensitivity.	Vitamin D	58-67	insulin	Homo sapiens	89-96
23206285-2	2012	The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present.	Vitamin D	19-28	cadherin 1	Homo sapiens	142-152
22967804-8	2012	In this report, we show several experimental evidences that vitamin D(3) modulates mTOR pathway, and present a hypothesis that the combination of mTOR inhibitor and vitamin D(3) can effectively inhibit osteoclast differentiation and function in chronic inflammatory condition such as RA, therefore this combination will be a powerful therapeutic regimen in preventing the inflammation-induced bone destruction in RA.	Vitamin D	60-69	mechanistic target of rapamycin kinase	Homo sapiens	83-87
22967804-8	2012	In this report, we show several experimental evidences that vitamin D(3) modulates mTOR pathway, and present a hypothesis that the combination of mTOR inhibitor and vitamin D(3) can effectively inhibit osteoclast differentiation and function in chronic inflammatory condition such as RA, therefore this combination will be a powerful therapeutic regimen in preventing the inflammation-induced bone destruction in RA.	Vitamin D	60-69	mechanistic target of rapamycin kinase	Homo sapiens	146-150
22967804-8	2012	In this report, we show several experimental evidences that vitamin D(3) modulates mTOR pathway, and present a hypothesis that the combination of mTOR inhibitor and vitamin D(3) can effectively inhibit osteoclast differentiation and function in chronic inflammatory condition such as RA, therefore this combination will be a powerful therapeutic regimen in preventing the inflammation-induced bone destruction in RA.	Vitamin D	165-174	mechanistic target of rapamycin kinase	Homo sapiens	83-87
23065818-9	2012	CONCLUSION: The improvement of both proinflammatory status and glucose uptake in adipocytes under 1,25-(OH)(2) D(3)  effect suggests that low-grade inflammation could be linked to vitamin D deficiency.	Vitamin D	180-189	iodothyronine deiodinase 3	Homo sapiens	111-115
22903070-1	2012	Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells.	Vitamin D	93-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	162-168
22218874-0	2012	The impact of vitamin D status and tumor size on the intraoperative parathyroid hormone dynamics in patients with symptomatic primary hyperparathyroidism.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	68-87
22939842-2	2012	We report that exposure to the active hormonal form of vitamin D markedly increased gene expression of CYP3A4 and CYP3A5 and ultimately achieved levels of intracellular CYP3A enzyme activity within LNCaP prostate cancer cells that were comparable to that observed for Caco2 cells, an established model of CYP3A induction, and resulted in the increased turnover of testosterone to its inactive 6beta-OH metabolite.	Vitamin D	55-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-119
23055531-5	2012	A functional vitamin D response element was defined in the 5-prime regulatory region of the miR-498 genome, which is occupied by the vitamin D receptor and its coactivators.	Vitamin D	13-22	microRNA 498	Homo sapiens	92-99
22317756-9	2012	Mean apoA-I concentration increased in the vitamin D group, although it decreased in the placebo group (0 04 (sd 0 39) v. - 0 25 (sd 0 2) g/l; P &lt;= 0 001).	Vitamin D	43-52	apolipoprotein A1	Homo sapiens	5-11
22317756-10	2012	Mean LDL-cholesterol:apoB-100 ratio augmented in the vitamin D group, while this ratio declined in the placebo group (0 11 (sd 0 6) v. - 0 19 (sd 0 3); P = 0 014).	Vitamin D	53-62	apolipoprotein B	Homo sapiens	21-29
22939842-2	2012	We report that exposure to the active hormonal form of vitamin D markedly increased gene expression of CYP3A4 and CYP3A5 and ultimately achieved levels of intracellular CYP3A enzyme activity within LNCaP prostate cancer cells that were comparable to that observed for Caco2 cells, an established model of CYP3A induction, and resulted in the increased turnover of testosterone to its inactive 6beta-OH metabolite.	Vitamin D	55-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-109
22932684-8	2012	Vitamin D(3) induced pro-MMP-2 activity (1.29 +- 0.17) and VEGF mRNA levels (1.74 +- 0.73) in ECFCs.	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	59-63
22939842-2	2012	We report that exposure to the active hormonal form of vitamin D markedly increased gene expression of CYP3A4 and CYP3A5 and ultimately achieved levels of intracellular CYP3A enzyme activity within LNCaP prostate cancer cells that were comparable to that observed for Caco2 cells, an established model of CYP3A induction, and resulted in the increased turnover of testosterone to its inactive 6beta-OH metabolite.	Vitamin D	55-64	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	114-120
22939842-2	2012	We report that exposure to the active hormonal form of vitamin D markedly increased gene expression of CYP3A4 and CYP3A5 and ultimately achieved levels of intracellular CYP3A enzyme activity within LNCaP prostate cancer cells that were comparable to that observed for Caco2 cells, an established model of CYP3A induction, and resulted in the increased turnover of testosterone to its inactive 6beta-OH metabolite.	Vitamin D	55-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-108
22884583-5	2012	We found that overexpression of PPARgamma decreased 1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) mediated transcriptional activity of the vitamin D target gene, CYP24A1, by 49% and the activity of VDRE-luc, a vitamin D responsive reporter, by 75% in T47D human breast cancer cells.	Vitamin D	71-80	peroxisome proliferator activated receptor gamma	Homo sapiens	32-41
22884583-5	2012	We found that overexpression of PPARgamma decreased 1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) mediated transcriptional activity of the vitamin D target gene, CYP24A1, by 49% and the activity of VDRE-luc, a vitamin D responsive reporter, by 75% in T47D human breast cancer cells.	Vitamin D	136-145	peroxisome proliferator activated receptor gamma	Homo sapiens	32-41
22932684-11	2012	Consequently, vitamin D(3) significantly promoted angiogenesis in ECFCs in vitro possibly due to an increase in VEGF expression and pro-MMP-2 activity.	Vitamin D	14-23	vascular endothelial growth factor A	Homo sapiens	112-116
22930691-1	2012	Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalacia.	Vitamin D	256-265	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	115-119
23306760-1	2012	The role of vitamin D (Vit.	Vitamin D	12-21	vitrin	Homo sapiens	23-26
22784837-1	2012	OBJECTIVE: Hypocalcemia and hyperphosphatemia in the setting of elevated parathyroid hormone (PTH) and normal vitamin D metabolites, raises the possibility of PTH resistance.	Vitamin D	110-119	parathyroid hormone	Homo sapiens	159-162
22962257-8	2012	We identified a functional vitamin D-responsive element in the mouse Pyy promoter using chromatin immunoprecipitation assay, EMSA, and luciferase promoter assay.	Vitamin D	27-36	peptide YY	Mus musculus	69-72
22962257-10	2012	The pancreatic VDR-PYY pathway may mediate a regulatory function of vitamin D in the neuroendocrine system.	Vitamin D	68-77	peptide YY	Mus musculus	19-22
22841897-3	2012	We have previously reported that the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25-(OH)(2)D(3)), inhibits tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation.	Vitamin D	52-61	tumor necrosis factor	Homo sapiens	129-156
22841897-3	2012	We have previously reported that the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25-(OH)(2)D(3)), inhibits tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation.	Vitamin D	52-61	tumor necrosis factor	Homo sapiens	158-167
22841897-3	2012	We have previously reported that the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25-(OH)(2)D(3)), inhibits tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation.	Vitamin D	52-61	nuclear factor kappa B subunit 1	Homo sapiens	177-186
22710945-10	2012	Disruption of the vitamin D-PTH axis may contribute to the bone loss seen in the chronic SCI population.	Vitamin D	18-27	parathyroid hormone	Homo sapiens	28-31
23082050-4	2012	Vitamin D also exerts its effects on viral hepatitis via non-genomic factors, i.e., matrix metalloproteinase, endothelial vascular growth factor, prostaglandins, cyclooxygenase-2, and oxidative stress.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	162-178
23168851-2	2012	It is reported that vitamin D analogues are able to suppress renin excretion.	Vitamin D	20-29	renin	Homo sapiens	61-66
23095332-1	2012	BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor.	Vitamin D	127-136	cathelicidin antimicrobial peptide	Homo sapiens	33-67
23095332-1	2012	BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor.	Vitamin D	127-136	cathelicidin antimicrobial peptide	Homo sapiens	69-73
23095332-3	2012	We hypothesized that serum vitamin D levels may modulate the circulating levels of hCAP18.	Vitamin D	27-36	cathelicidin antimicrobial peptide	Homo sapiens	83-89
23095332-8	2012	CONCLUSIONS: We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D &lt;= 32 ng/ml as opposed to those with concentrations &gt; 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37.	Vitamin D	208-217	cathelicidin antimicrobial peptide	Homo sapiens	37-43
22704696-2	2012	Interferon (IFN)-gamma is an inflammatory cytokine that regulates vitamin D metabolism in isolated immune cells, but data suggesting this regulation exists in vivo is lacking.	Vitamin D	66-75	interferon gamma	Homo sapiens	0-22
22695798-9	2012	Gene and protein expression of hCAP-18 (p &lt; 0.05) showed an increase in sebocytes treated with vitamin D.	Vitamin D	98-107	cathelicidin antimicrobial peptide	Homo sapiens	31-38
22695798-10	2012	Gene expression of hCAP-18 by treatment with vitamin D was blocked in sebocytes treated with VDR siRNA.	Vitamin D	45-54	cathelicidin antimicrobial peptide	Homo sapiens	19-26
22695798-11	2012	In conclusion, treatment with vitamin D resulted in increased expression of LL-37 through the vitamin D receptor of cultured sebocytes.	Vitamin D	30-39	cathelicidin antimicrobial peptide	Homo sapiens	76-81
22796589-8	2012	Furthermore, depending on the type of allele present (G or A), the binding of several important nuclear factors such as the vitamin D or the retinoic acid receptors is predicted to be altered at this position, suggesting a significant effect in the regulation of transcription of the OPTN gene.	Vitamin D	124-133	optineurin	Homo sapiens	284-288
22964475-5	2012	In the vitamin D(3)-supplemented group relative to placebo, the proportion of APC in the upper 40% of crypts (Phih APC) increased 21% (P = 0.01), beta-catenin decreased 12% (P = 0.18), E-cadherin increased 72% (P = 0.03), and the Phih APC/beta-catenin ratio (APC/beta-catenin score) increased 31% (P = 0.02).	Vitamin D	7-16	cadherin 1	Homo sapiens	185-195
22751957-0	2012	Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006.	Vitamin D	29-38	insulin	Homo sapiens	56-63
22964475-8	2012	These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	43-52	cadherin 1	Homo sapiens	83-93
22964475-8	2012	These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	43-52	cadherin 1	Homo sapiens	326-336
22964475-8	2012	These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	200-209	cadherin 1	Homo sapiens	326-336
22715179-11	2012	Severe vitamin D deficiency (total 25(OH)D &lt;25 nmol/L) was associated with higher baseline TNF, IL-6, and IL-8 irrespective of IRIS status.	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	94-97
22715179-11	2012	Severe vitamin D deficiency (total 25(OH)D &lt;25 nmol/L) was associated with higher baseline TNF, IL-6, and IL-8 irrespective of IRIS status.	Vitamin D	7-16	interleukin 6	Homo sapiens	99-103
22715179-11	2012	Severe vitamin D deficiency (total 25(OH)D &lt;25 nmol/L) was associated with higher baseline TNF, IL-6, and IL-8 irrespective of IRIS status.	Vitamin D	7-16	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
22801788-3	2012	Vitamin D also exerts protective effects against SLE through non-genomic factors, such as ultraviolet radiation (UV) exposure, matrix metalloproteinase (MMPs), heme oxygenase-1 (HO-1), the prostaglandins (PGs), cyclooxygenase-2 (COX-2), and oxidative stress.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	211-227
22801788-3	2012	Vitamin D also exerts protective effects against SLE through non-genomic factors, such as ultraviolet radiation (UV) exposure, matrix metalloproteinase (MMPs), heme oxygenase-1 (HO-1), the prostaglandins (PGs), cyclooxygenase-2 (COX-2), and oxidative stress.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	229-234
22800603-8	2012	A similar suppressive effect of vitamin D(3) was observed with MIG protein in healthy controls (p=0.0029) and a trend towards a suppression was observed in PTB patients.	Vitamin D	32-41	C-X-C motif chemokine ligand 9	Homo sapiens	63-66
22704696-8	2012	We conclude that IFN-gamma contributes to the decrease in vitamin D and the conversion of vitamin D to its active hormonal form in the circulation during inflammatory insult in humans.	Vitamin D	58-67	interferon gamma	Homo sapiens	17-26
22704696-8	2012	We conclude that IFN-gamma contributes to the decrease in vitamin D and the conversion of vitamin D to its active hormonal form in the circulation during inflammatory insult in humans.	Vitamin D	90-99	interferon gamma	Homo sapiens	17-26
22855339-1	2012	CONTEXT: Inherited forms of vitamin D deficiency are rare causes of rickets and to date have been traced to mutations in three genes, VDR, encoding the 1alpha,25-dihydroxyvitamin D receptor, CYP27B1, encoding the vitamin D 1alpha-hydroxylase, and CYP2R1, encoding a microsomal vitamin D 25-hydroxylase.	Vitamin D	28-37	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	191-198
22562539-9	2012	Vitamin D deficiency has been associated with higher rates of diabetes and colorectal cancer, particularly in individuals with high serum insulin and IGF-1 levels.	Vitamin D	0-9	insulin	Homo sapiens	138-145
22562539-9	2012	Vitamin D deficiency has been associated with higher rates of diabetes and colorectal cancer, particularly in individuals with high serum insulin and IGF-1 levels.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	150-155
22903229-10	2012	A positive in vivo correlation between vitamin D status and CD4(+) Foxp3(+)  T cells in the airways was observed in a severe pediatric asthma cohort, supporting the in vitro observations.	Vitamin D	39-48	CD4 molecule	Homo sapiens	60-63
22487892-2	2012	Recent studies show that supplementation of vitamin D significantly improves sustained viral response via IFN-based therapy.	Vitamin D	44-53	interferon alpha 1	Homo sapiens	106-109
24991591-0	2012	Does the intramuscular injection of vitamin D increase insulin resistance?	Vitamin D	36-45	insulin	Homo sapiens	55-62
22634121-5	2012	Vitamin D deficiency also closely relates to the severity of non-alcoholic fatty liver disease (NAFLD) and is implicated in the pathogenesis of insulin resistance, a key factor in the development of NAFLD.	Vitamin D	0-9	insulin	Homo sapiens	144-151
22701042-6	2012	The discovery of LL-37-inducing components, such as butyrate and vitamin D(3), has opened new avenues to prevent or treat infections.	Vitamin D	65-74	cathelicidin antimicrobial peptide	Homo sapiens	17-22
22701042-7	2012	Butyrate and vitamin D(3) are potent inducers of LL-37 but in addition, have many other effects on host immunity.	Vitamin D	13-22	cathelicidin antimicrobial peptide	Homo sapiens	49-54
22626544-9	2012	Identification of novel heart VIPs and their influence on VDR activity may increase our understanding of how vitamin D impacts cardiac physiology and may facilitate development of VDR/VIP drug analogs to combat heart disease.	Vitamin D	109-118	vasoactive intestinal peptide	Homo sapiens	30-33
24991591-1	2012	OBJECTIVE: Considering the physiologic roles of vitamin D on insulin regulation, the effects of vitamin D treatment on insulin sensitivity and resistance indexes and beta cell function in pre-diabetic vitamin D deficient patients were investigated.	Vitamin D	96-105	insulin	Homo sapiens	119-126
24991591-1	2012	OBJECTIVE: Considering the physiologic roles of vitamin D on insulin regulation, the effects of vitamin D treatment on insulin sensitivity and resistance indexes and beta cell function in pre-diabetic vitamin D deficient patients were investigated.	Vitamin D	96-105	insulin	Homo sapiens	119-126
24991591-8	2012	CONCLUSION: Injection of vitamin D increased insulin resistance and decreased insulin sensitivity indexes.	Vitamin D	25-34	insulin	Homo sapiens	45-52
24991591-8	2012	CONCLUSION: Injection of vitamin D increased insulin resistance and decreased insulin sensitivity indexes.	Vitamin D	25-34	insulin	Homo sapiens	78-85
23185165-9	2012	Malignancy-associated hypercalcemia occurs via four principal mechanisms: (1) tumor production of PTHrP; (2) osteolytic bone involvement by primary tumor or metastasis; (3) ectopic activation of vitamin D to 1,25-(OH)(2) vitamin D, and (4) ectopic production of parathyroid hormone.	Vitamin D	195-204	parathyroid hormone	Homo sapiens	262-281
22627120-10	2012	CD209(+) dendritic cells inversely correlated with vitamin D(3) but not costimulatory molecule expression.	Vitamin D	51-60	CD209 molecule	Homo sapiens	0-5
23006613-7	2012	Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11+-12 cmH2O vs 0+-14 cmH2O; p = 0.004) and maximal oxygen uptake (110+-211 ml/min vs -20+-187 ml/min; p = 0.029).	Vitamin D	19-28	troponin T2, cardiac type	Homo sapiens	107-111
22949664-6	2012	Administration of vitamin D also suppressed antigen-stimulated proinflammatory cytokine responses, but attenuated the suppressive effect of antimicrobial therapy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-alpha.	Vitamin D	18-27	interleukin 4	Homo sapiens	197-201
22949664-6	2012	Administration of vitamin D also suppressed antigen-stimulated proinflammatory cytokine responses, but attenuated the suppressive effect of antimicrobial therapy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-alpha.	Vitamin D	18-27	interferon alpha 1	Homo sapiens	230-239
22861070-6	2012	While the skeletal and cardiovascular systems of HIV patients may be adversely impacted as a result of low levels, recent data have also linked low vitamin D to decreased CD4 counts, higher viral loads, and to critical end points including progression to AIDS events and death.	Vitamin D	148-157	CD4 molecule	Homo sapiens	171-174
23063903-1	2012	CYP2R1 (25alpha-hydroxylase) catalyzes vitamin D(3) to 25-hydroxyvitamin D(3), while the CYP27B1 (1alpha-hydroxylase) catalyzes the 25(OH)D(3) to 1, 25(OH)(2)D(3).	Vitamin D	39-48	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	89-96
22215183-3	2012	We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	137-156
22215183-3	2012	We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	158-161
23021134-7	2012	Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P &lt; .0001), greater PTH levels (P &lt; .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05).	Vitamin D	173-182	parathyroid hormone	Homo sapiens	84-87
23021134-7	2012	Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P &lt; .0001), greater PTH levels (P &lt; .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05).	Vitamin D	173-182	parathyroid hormone	Homo sapiens	84-87
23021134-7	2012	Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P &lt; .0001), greater PTH levels (P &lt; .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05).	Vitamin D	227-236	parathyroid hormone	Homo sapiens	84-87
23021134-7	2012	Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P &lt; .0001), greater PTH levels (P &lt; .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05).	Vitamin D	227-236	parathyroid hormone	Homo sapiens	84-87
23021134-11	2012	The greater PTH levels and lesser vitamin D levels support postoperative vitamin D supplementation in these patients.	Vitamin D	73-82	parathyroid hormone	Homo sapiens	12-15
22854402-7	2012	PTH decreased from baseline only in the vitamin D group (baseline: 89.1 +- 49.3 to 70.1 +- 24.8 pg/mL; P = 0.01) at 12 wk, but values were not significantly different from baseline at 1 y (75.4 +- 29.5 pg/mL; P = 0.16; group-by-time interaction: P = 0.09).	Vitamin D	40-49	parathyroid hormone	Homo sapiens	0-3
22588163-1	2012	Pseudovitamin D-deficiency rickets (PDDR) is an autosomal recessive disorder resulting from a defect in renal 25-hydroxyvitamin D 1alpha-hydroxylase, the key enzyme in the pathway of vitamin D metabolism.	Vitamin D	6-15	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
22443290-1	2012	CONTEXT: Vitamin D-dependent rickets type 1A (VDDR-IA, OMIM 264700) is a rare autosomal recessive disorder and is caused by mutations in the CYP27B1 gene.	Vitamin D	9-18	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	141-148
22574874-3	2012	There is some, but limited, evidence for beneficial effects of vitamin D supplementation on menstrual dysfunction and insulin resistance in women with PCOS.	Vitamin D	63-72	insulin	Homo sapiens	118-125
22805498-5	2012	In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-alpha (TNF-alpha) at 12 weeks (P&lt;0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09).	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	55-82
22486948-8	2012	Insulin secretion increased by 12% in the vitamin D group compared with a 2% increase in the placebo group (p = 0.024), but changes in the disposition index were similar across groups.	Vitamin D	42-51	insulin	Homo sapiens	0-7
22486948-3	2012	This study was conducted to determine whether vitamin D supplementation improves insulin secretion, insulin sensitivity and glycaemia in African Americans with prediabetes or early diabetes.	Vitamin D	46-55	insulin	Homo sapiens	81-88
22486948-7	2012	Insulin sensitivity decreased by 4% in the vitamin D group compared with a 12% increase in the placebo group (p = 0.034).	Vitamin D	43-52	insulin	Homo sapiens	0-7
22805498-5	2012	In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-alpha (TNF-alpha) at 12 weeks (P&lt;0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09).	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	84-93
22805498-5	2012	In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-alpha (TNF-alpha) at 12 weeks (P&lt;0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09).	Vitamin D	7-16	interleukin 6	Homo sapiens	167-180
22805498-5	2012	In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-alpha (TNF-alpha) at 12 weeks (P&lt;0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09).	Vitamin D	7-16	interleukin 6	Homo sapiens	182-186
22805498-7	2012	We conclude that a large bolus dose of vitamin D is associated with reductions in two inflammatory cytokines, IL-6 and TNF-alpha.	Vitamin D	39-48	interleukin 6	Homo sapiens	110-114
22805498-7	2012	We conclude that a large bolus dose of vitamin D is associated with reductions in two inflammatory cytokines, IL-6 and TNF-alpha.	Vitamin D	39-48	tumor necrosis factor	Homo sapiens	119-128
25246913-4	2012	Accumulating evidence suggests that vitamin D has a role on insulin sensitivity so may contribute to reduction of hyperandrogenemia.	Vitamin D	36-45	insulin	Homo sapiens	60-67
22851187-16	2012	It is observed that Vitamin D attenuated TGF-beta1 expression.	Vitamin D	20-29	transforming growth factor, beta 1	Rattus norvegicus	41-50
22851187-17	2012	The results of this study suggest that vitamin D may play role in folliculogenesis via TGF-beta1.	Vitamin D	39-48	transforming growth factor, beta 1	Rattus norvegicus	87-96
22851187-0	2012	The effect of vitamin D on expression of TGF beta1 in ovary.	Vitamin D	14-23	transforming growth factor, beta 1	Rattus norvegicus	41-50
22851187-14	2012	We found that vitamin D administration resulted in a decrease in TGF-beta1 levels in the adult rats, but, TGF-beta1 expression did not significantly decrease in the newborn rats.	Vitamin D	14-23	transforming growth factor, beta 1	Rattus norvegicus	65-74
22851187-15	2012	However, in multiple linear regression analysis, TGF-beta1 expressions were independently associated with vitamin D administration.	Vitamin D	106-115	transforming growth factor, beta 1	Rattus norvegicus	49-58
22473758-13	2012	Vitamin D unresponsive hypoparathyroidism maybe safely and effectively controlled at long term by s. c. multipulse pump treatment recombinant human PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	148-151
23351271-0	2012	Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial.	Vitamin D	10-19	insulin	Homo sapiens	23-30
22770938-12	2012	Besides, the activity of various glucose metabolic enzymes (hexokinase, FBPase and G6Pase) as shown by our results and the remarkable shortening of DNA tail length in vitamin D supplemented diabetic group as compared to diabetic group without supplementation further support the idea that vitamin D supplementation might be an add-on therapy for patients with T2DM.	Vitamin D	167-176	hexokinase 1	Homo sapiens	60-70
22770938-12	2012	Besides, the activity of various glucose metabolic enzymes (hexokinase, FBPase and G6Pase) as shown by our results and the remarkable shortening of DNA tail length in vitamin D supplemented diabetic group as compared to diabetic group without supplementation further support the idea that vitamin D supplementation might be an add-on therapy for patients with T2DM.	Vitamin D	289-298	hexokinase 1	Homo sapiens	60-70
22947548-0	2012	Bisphosphonate therapy for painless fracture: change of HSAN 1 clinical course with biphosphonate and Vitamin D therapy.	Vitamin D	102-111	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	56-62
22947548-3	2012	The authors believe that combined bisphosphonate and vitamin D therapy is the treatment of choice for progressive bony changes in HSAN1.	Vitamin D	53-62	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	130-135
22766894-11	2012	Seasonal measurements of vitamin D status, PTH levels and bone turnover markers exhibit that PTH levels, osteocalcin and beta crosslaps increase in response to low vitamin D levels.	Vitamin D	164-173	bone gamma-carboxyglutamate protein	Homo sapiens	105-116
22710573-8	2012	Studies delineating key functional pathways in HCC and CSC formation could be important in preventing this disease and could lead to simple treatment strategies; for example, use of vitamin D might be effective when the TGF-beta pathway is lost or when wnt signalling is activated.	Vitamin D	182-191	transforming growth factor beta 1	Homo sapiens	220-228
22801352-8	2012	We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth.	Vitamin D	28-37	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	154-161
22736772-8	2012	RESULTS: Five PHP1B patients developed concomitantly elevated serum calcium and PTH levels (range, 235-864 ng/liter) requiring termination of calcium and vitamin D therapy (time after diagnosis, 21-42 yr; median, 34 yr), consistent with tertiary hyperparathyroidism.	Vitamin D	154-163	parathyroid hormone	Homo sapiens	80-83
22736772-12	2012	CONCLUSIONS: PHP1B patients are at risk of developing tertiary hyperparathyroidism and/or hyperparathyroid bone disease and should therefore be treated with sufficient doses of calcium and vitamin D to achieve serum calcium and PTH levels within or as close to the normal range as possible.	Vitamin D	189-198	parathyroid hormone	Homo sapiens	228-231
22766894-11	2012	Seasonal measurements of vitamin D status, PTH levels and bone turnover markers exhibit that PTH levels, osteocalcin and beta crosslaps increase in response to low vitamin D levels.	Vitamin D	164-173	parathyroid hormone	Homo sapiens	93-96
22683670-0	2012	NFkappaB pathway is down-regulated by 1alpha,25(OH)(2)-vitamin D(3) in endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein coupled receptor.	Vitamin D	55-64	nuclear factor kappa B subunit 1	Homo sapiens	0-8
22572998-8	2012	Ovaries of vitamin D(3)-deficient Cyp27b1 null mice responded to exogenous gonadotropins and deposited significantly more oocytes into the oviducts than mice maintained on a vitamin D(3)-replete diet.	Vitamin D	11-20	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	34-41
24199029-7	2012	Non-medicated, normoglycemic, non-hypertensive individuals classified as vitamin D deficient (n=289) exhibited a significant increase in fasting glucose (p=0.02) and BMI (p&lt;0.0001) as well as a significant decrease in C-peptide (p&lt;0.0001) and amylin (p&lt;0.0001) compared to vitamin D sufficient controls (n=150).	Vitamin D	73-82	insulin	Homo sapiens	221-230
23351271-4	2012	This study was designed to investigate the effect of injection of vitamin D on insulin resistance and anthropometric parameters in T2DM.	Vitamin D	66-75	insulin	Homo sapiens	79-86
22648952-10	2012	We found that expression of VDR and CYP27B1 increased significantly at day 7 of regeneration, and these results confirm the expression of Vdr and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury.	Vitamin D	195-204	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	36-43
22898564-3	2012	Immunomodulatory effects of vitamin D may act not only through modulation of T-helper cell function, but also through induction of CD4(+)CD25(high) regulatory T-cells.	Vitamin D	28-37	CD4 molecule	Homo sapiens	131-134
22648952-6	2012	The observation that treatment of C2C12 myoblasts with the inactive form of vitamin D(3), [25(OH)D(3)], inhibited proliferation suggested that CYP27B1 was functionally active.	Vitamin D	76-85	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	143-150
22863393-3	2012	PTH is a key calcium regulating hormone essential for calcium homeostasis, vitamin D-dependant calcium absorption, renal calcium reabsorption and renal phosphate clearance.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	0-3
22786591-1	2012	OBJECTIVE: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk.	Vitamin D	35-44	major histocompatibility complex, class II, DR beta 1	Homo sapiens	80-88
22686937-7	2012	Vitamin D deficiency was associated with higher total IgE only in the carriers of the "C" allele (IL4), which is present in 86% of white Europeans, while only 26% of Chinese and &lt;20% of some African populations are carriers.	Vitamin D	0-9	interleukin 4	Homo sapiens	98-101
22786591-1	2012	OBJECTIVE: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk.	Vitamin D	35-44	major histocompatibility complex, class II, DR beta 1	Homo sapiens	80-83
22786591-1	2012	OBJECTIVE: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk.	Vitamin D	197-206	major histocompatibility complex, class II, DR beta 1	Homo sapiens	80-88
22786591-1	2012	OBJECTIVE: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk.	Vitamin D	197-206	major histocompatibility complex, class II, DR beta 1	Homo sapiens	80-83
22786591-9	2012	An independent contribution of VDRE motif variation to increase MS risk was not discernible, although vitamin D-dependent regulation of HLA-DR expression may still play an important role given that HLA-DRB1*04/*07/*09 (DR53) alleles that express the "nonresponsive" VDRE motif were associated with significantly reduced risk of MS.	Vitamin D	102-111	major histocompatibility complex, class II, DR beta 1	Homo sapiens	136-139
22648128-2	2012	The discovery of the vitamin D receptor and its possible effects on components of the cardiovascular system influencing blood pressure, such as the renin angiotensin system, the heart, the kidney and the blood vessels, has generated the hope that vitamin D therapy could be a new target for the treatment for hypertensive patients.	Vitamin D	21-30	renin	Homo sapiens	148-153
22710747-6	2012	One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade.	Vitamin D	104-113	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	140-147
22528806-1	2012	The serum vitamin D binding protein (DBP), also known as GC-globulin, is a multifunctional protein known for its role in the transport of vitamin D metabolites.	Vitamin D	10-19	D-box binding PAR bZIP transcription factor	Homo sapiens	37-40
22528806-3	2012	DBP may have immune functions independent of its role as a transporter of vitamin D.	Vitamin D	74-83	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
22528806-7	2012	With the recent increased attention regarding the benefits of vitamin D (bone health and immunological regulation), there has been a resurgence of interest in DBP.	Vitamin D	62-71	D-box binding PAR bZIP transcription factor	Homo sapiens	159-162
22528806-8	2012	Because DBP is the primary transporter of vitamin D, it has a role in maintaining the total levels of vitamin D for the organism and in regulating the amounts of free (unbound) vitamin D available for specific tissues and cell types to utilize.	Vitamin D	42-51	D-box binding PAR bZIP transcription factor	Homo sapiens	8-11
22528806-8	2012	Because DBP is the primary transporter of vitamin D, it has a role in maintaining the total levels of vitamin D for the organism and in regulating the amounts of free (unbound) vitamin D available for specific tissues and cell types to utilize.	Vitamin D	102-111	D-box binding PAR bZIP transcription factor	Homo sapiens	8-11
22528806-8	2012	Because DBP is the primary transporter of vitamin D, it has a role in maintaining the total levels of vitamin D for the organism and in regulating the amounts of free (unbound) vitamin D available for specific tissues and cell types to utilize.	Vitamin D	102-111	D-box binding PAR bZIP transcription factor	Homo sapiens	8-11
22528806-9	2012	This review will describe the findings on the basic biochemistry and molecular biology of DBP, the studies that elucidated its biological functions and highlight these results in light of the current renewed interest in vitamin D and human health, as well as the debate over what constitutes sufficient levels of vitamin D.	Vitamin D	220-229	D-box binding PAR bZIP transcription factor	Homo sapiens	90-93
22528806-9	2012	This review will describe the findings on the basic biochemistry and molecular biology of DBP, the studies that elucidated its biological functions and highlight these results in light of the current renewed interest in vitamin D and human health, as well as the debate over what constitutes sufficient levels of vitamin D.	Vitamin D	313-322	D-box binding PAR bZIP transcription factor	Homo sapiens	90-93
22247968-7	2012	CONCLUSIONS: The findings suggest that vitamin D deficiency, possibly involving altered insulin sensitivity, is associated with an increased risk for diabetes mellitus in the Korean population.	Vitamin D	39-48	insulin	Homo sapiens	88-95
22969780-3	2012	Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH to nitric oxide metabolites (NOx) - nitrate and nitrite - and oxidative stress in African-Americans is unknown.	Vitamin D	30-39	parathyroid hormone	Homo sapiens	75-78
22260937-1	2012	BACKGROUND &amp; AIMS: Recent investigations have identified low vitamin D status as a hypothetical mechanism of insulin-resistance in Polycystic Ovary Syndrome (PCOS).	Vitamin D	65-74	insulin	Homo sapiens	113-120
22486204-0	2012	Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis.	Vitamin D	10-19	insulin	Homo sapiens	61-68
22486204-1	2012	AIMS: To systematically review the evidence for the effect of vitamin D supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes.	Vitamin D	62-71	insulin	Homo sapiens	102-109
22339716-12	2012	Considering that the active form of vitamin D suppresses PTH production, it is hypothesised that vitamin D replenishment of just those who are genetically prone to the disease (i.e. siblings) may be regarded as a preventive measure against T1D.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	57-60
22537546-1	2012	INTRODUCTION: Vitamin D is a sectosteroid that functions through Vitamin D receptor (VDR), a transcription factor, which controls the transcription of many targets genes.	Vitamin D	14-23	vitamin D receptor	Sus scrofa	65-83
22537546-1	2012	INTRODUCTION: Vitamin D is a sectosteroid that functions through Vitamin D receptor (VDR), a transcription factor, which controls the transcription of many targets genes.	Vitamin D	14-23	vitamin D receptor	Sus scrofa	85-88
22537546-4	2012	OBJECTIVE: The purpose of this study was to test the hypothesis that vitamin D deficiency causes cardiomyocyte hypertrophy and increased proinflammatory profile in epicardial adipose tissue (EAT), and this correlates with decreased expression of SOCS3 in cardiomyocytes and EAT.	Vitamin D	69-78	suppressor of cytokine signaling 3	Sus scrofa	246-251
22537546-9	2012	Immunohistochemical and qPCR analyses showed significantly decreased mRNA and protein expression of VDR and SOCS3 in cardiomyocytes of vitamin D-deficient animals.	Vitamin D	135-144	vitamin D receptor	Sus scrofa	100-103
22537546-9	2012	Immunohistochemical and qPCR analyses showed significantly decreased mRNA and protein expression of VDR and SOCS3 in cardiomyocytes of vitamin D-deficient animals.	Vitamin D	135-144	suppressor of cytokine signaling 3	Sus scrofa	108-113
22537546-11	2012	Interestingly, EAT from vitamin D-deficient group had significantly decreased expression of SOCS3.	Vitamin D	24-33	suppressor of cytokine signaling 3	Sus scrofa	92-97
22537546-12	2012	CONCLUSION: These data suggest that vitamin D deficiency induces hypertrophy in cardiomyocytes which is associated with decreased expression of VDR and SOCS3.	Vitamin D	36-45	vitamin D receptor	Sus scrofa	144-147
22537546-12	2012	CONCLUSION: These data suggest that vitamin D deficiency induces hypertrophy in cardiomyocytes which is associated with decreased expression of VDR and SOCS3.	Vitamin D	36-45	suppressor of cytokine signaling 3	Sus scrofa	152-157
22537546-14	2012	Activity of VDR in the body is controlled through regulation of vitamin D metabolites.	Vitamin D	64-73	vitamin D receptor	Sus scrofa	12-15
22537546-15	2012	Therefore, restoration of VDR function by supplementation of VDR ligands in vitamin D-deficient population might be helpful in reducing inflammation and cardiovascular risk.	Vitamin D	76-85	vitamin D receptor	Sus scrofa	26-29
22537546-15	2012	Therefore, restoration of VDR function by supplementation of VDR ligands in vitamin D-deficient population might be helpful in reducing inflammation and cardiovascular risk.	Vitamin D	76-85	vitamin D receptor	Sus scrofa	61-64
22537547-12	2012	There was significantly increased expression of TNF-alpha and decreased expression of VDR and prohibitin in the lung of vitamin D-deficient mouse model of allergic airway inflammation.	Vitamin D	120-129	tumor necrosis factor	Mus musculus	48-57
22537547-14	2012	Vitamin D deficiency causes increase in the expression of TNF-alpha, thereby increasing inflammation and decreases the expression of VDR and prohibitin.	Vitamin D	0-9	tumor necrosis factor	Mus musculus	58-67
22553308-0	2012	A novel CYP27B1 mutation causes a feline vitamin D-dependent rickets type IA.	Vitamin D	41-50	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	8-15
22553308-4	2012	Vitamin D-dependent rickets type 1A (VDDR-1A) is a result of the enzymatic pathway defect caused by mutations in the 25-hydroxyvitamin D(3)-1-alpha-hydroxylase gene [cytochrome P27 B1 (CYP27B1)].	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	117-159
22553308-4	2012	Vitamin D-dependent rickets type 1A (VDDR-1A) is a result of the enzymatic pathway defect caused by mutations in the 25-hydroxyvitamin D(3)-1-alpha-hydroxylase gene [cytochrome P27 B1 (CYP27B1)].	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	166-183
22553308-4	2012	Vitamin D-dependent rickets type 1A (VDDR-1A) is a result of the enzymatic pathway defect caused by mutations in the 25-hydroxyvitamin D(3)-1-alpha-hydroxylase gene [cytochrome P27 B1 (CYP27B1)].	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	185-192
22537547-15	2012	Supplementation with vitamin D might reduce the levels of TNF-alpha, thereby increasing the expression of VDR and prohibitin that could be responsible for reducing allergic airway inflammation.	Vitamin D	21-30	tumor necrosis factor	Mus musculus	58-67
22595957-7	2012	Further adjustment for vitamin D explained 14 and 6% of these SBP and DBP differences, respectively.	Vitamin D	23-32	D-box binding PAR bZIP transcription factor	Homo sapiens	70-73
22595957-9	2012	Variation in vitamin D explained 7 and 4% of these SBP and DBP differences.	Vitamin D	13-22	D-box binding PAR bZIP transcription factor	Homo sapiens	59-62
22595957-11	2012	Vitamin D explained 25 and 17% of the variations in SBP and DBP, respectively, resulting in odds ratio of 1.9 (1.3-2.9) and 2.9 (2.0-4.3), respectively.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	60-63
22339716-12	2012	Considering that the active form of vitamin D suppresses PTH production, it is hypothesised that vitamin D replenishment of just those who are genetically prone to the disease (i.e. siblings) may be regarded as a preventive measure against T1D.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	57-60
22489804-9	2012	In CKD subjects, serum 25 (OH) vitamin D level showed a strong inverse correlation with CCA-IMT (r = -0.729, P &lt; 0.0001) and correlated with CD4+CD28null cell frequency (r = -0.249, P = 0.01) and hsCRP (r = -0.2, P = 0.047).	Vitamin D	31-40	CD4 molecule	Homo sapiens	144-147
22827382-9	2012	Associated with the decrease in AMH expression by vitamin D, follicle-stimulating hormone receptor mRNA is increased.	Vitamin D	50-59	follicle stimulating hormone receptor	Gallus gallus	61-98
22453735-1	2012	BACKGROUND: The role of vitamin D status in patients with renal insufficiency and its relation to dietary intake and parathyroid hormone (PTH) secretion is of utmost interest given the morbidity and mortality associated with the disordered mineral metabolism seen in chronic kidney disease (CKD).	Vitamin D	24-33	parathyroid hormone	Homo sapiens	117-136
22564824-7	2012	Epidemiological and experimental evidence suggest a better vitamin D status in apoE epsilon4 than epsilon3 subjects indicating a certain advantage of epsilon4 over epsilon3.	Vitamin D	59-68	apolipoprotein E	Homo sapiens	79-83
22704299-0	2012	Findings of a relation between vitamin D and C-reactive protein: concerns about methods used and conclusions drawn.	Vitamin D	31-40	C-reactive protein	Homo sapiens	45-63
22851868-1	2012	AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type III pro-collagen (PIIINP) as immune response mediators.	Vitamin D	15-24	vitrin	Homo sapiens	26-29
22306846-7	2012	The overexpression of VDR or vitamin D treatment suppressed amyloid precursor protein (APP) transcription in neuroblastoma cells (p < 0.001).	Vitamin D	29-38	amyloid beta precursor protein	Homo sapiens	60-85
22085499-4	2012	Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25D), critically linking overall vitamin D status with cellular anti-tumor actions.	Vitamin D	39-48	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
22085499-4	2012	Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25D), critically linking overall vitamin D status with cellular anti-tumor actions.	Vitamin D	142-151	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
22085499-4	2012	Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25D), critically linking overall vitamin D status with cellular anti-tumor actions.	Vitamin D	142-151	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
22484315-1	2012	Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression.	Vitamin D	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	186-192
22484315-8	2012	These data suggest VDR polymorphisms are predictors of intestinal CYP3A4, and that CYP3A4 intestinal expression varies seasonally--likely related to annual changes in UV sunlight and vitamin D levels.	Vitamin D	183-192	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-89
21913955-0	2012	Impact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients.	Vitamin D	20-29	insulin	Homo sapiens	33-40
21913955-1	2012	UNLABELLED: Although vitamin D deficiency has been associated with increased insulin resistance, a causal link has not been established.	Vitamin D	21-30	insulin	Homo sapiens	77-84
23158978-0	2012	Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome.	Vitamin D	0-9	insulin	Homo sapiens	28-35
23158978-9	2012	Insulin resistance was most severe in the sub group with vitamin D deficiency.	Vitamin D	57-66	insulin	Homo sapiens	0-7
23158978-10	2012	Multiple regression analysis established the role of vitamin D as the best predictor of insulin resistance in our study.	Vitamin D	53-62	insulin	Homo sapiens	88-95
23158978-11	2012	CONCLUSION: Vitamin D has an important role in the pathogenesis of insulin resistance in PCOS.	Vitamin D	12-21	insulin	Homo sapiens	67-74
22644348-2	2012	The purpose of the study was to evaluate the impact of a high-calcium vitamin D fortified milk (HCM) intervention on parathyroid hormone (PTH) levels, vitamin D status and markers of bone turnover in postmenopausal Chinese women.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	117-136
22699377-1	2012	Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action.	Vitamin D	18-27	D-box binding PAR bZIP transcription factor	Homo sapiens	154-157
22212745-0	2012	Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose.	Vitamin D	10-19	insulin	Homo sapiens	23-30
22212745-1	2012	AIM: Recent data has shown that vitamin D increases insulin sensitivity; however, there is little evidence about the effects of this treatment on elderly people with impaired fasting glucose.	Vitamin D	32-41	insulin	Homo sapiens	52-59
22212745-2	2012	The aim of the present study was to investigate the effect of vitamin D treatment on insulin sensitivity and metabolic parameters in elderly people with impaired fasting glucose.	Vitamin D	62-71	insulin	Homo sapiens	85-92
22212745-6	2012	After 4.7 +- 2.5 months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group (P = 0.007, P = 0.007, P = 0.037, respectively).	Vitamin D	168-177	insulin	Homo sapiens	106-113
22212745-6	2012	After 4.7 +- 2.5 months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group (P = 0.007, P = 0.007, P = 0.037, respectively).	Vitamin D	168-177	insulin	Homo sapiens	126-133
22212745-8	2012	CONCLUSION: We found that vitamin D treatment might modify insulin sensitivity in the elderly with impaired fasting glucose.	Vitamin D	26-35	insulin	Homo sapiens	59-66
22289117-2	2012	An interaction between human leukocyte antigen HLA-DRB1*15 and vitamin D in MS was recently proposed.	Vitamin D	63-72	major histocompatibility complex, class II, DR beta 1	Homo sapiens	47-55
22797100-8	2012	There was a significant correlation between vitamin D deficiency and high serum parathyroid hormone (P = .04) and serum creatinine levels (P = .001).	Vitamin D	44-53	parathyroid hormone	Homo sapiens	80-99
22539586-10	2012	There was a greater decline in RPF and higher stimulation of aldosterone with AngII infusion after vitamin D(3) therapy (both P &lt; 0.05).	Vitamin D	99-108	angiotensinogen	Homo sapiens	78-83
22539586-11	2012	As anticipated, captopril increased the renal-vascular, MAP, and adrenal sensitivity to AngII, but this effect was much smaller after vitamin D(3) therapy, indicating that vitamin D(3) therapy corrected the tissue sensitivity to AngII akin to captopril.	Vitamin D	172-181	angiotensinogen	Homo sapiens	229-234
22539586-12	2012	CONCLUSIONS: Vitamin D(3) therapy in obese hypertensives modified RPF, MAP, and tissue sensitivity to AngII similar to converting enzyme inhibition.	Vitamin D	13-22	angiotensinogen	Homo sapiens	102-107
22699377-3	2012	This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.	Vitamin D	77-86	D-box binding PAR bZIP transcription factor	Homo sapiens	70-73
22334534-3	2012	Vitamin D contributes to pulmonary health and promotes regulatory immune pathways, therefore its influence on CD200 and CD200R was investigated.	Vitamin D	0-9	CD200 receptor 1	Homo sapiens	120-126
23330289-1	2012	UNLABELLED: The serum level of the human cathelicidin-LL37, an immunomodulatory vitamin D-induced peptide was less studied in viral hepatitis.	Vitamin D	80-89	cathelicidin antimicrobial peptide	Homo sapiens	54-58
23330289-9	2012	The Pearson correlation between the vitamin D status and LL37 level was weak.	Vitamin D	36-45	cathelicidin antimicrobial peptide	Homo sapiens	57-61
26105278-1	2012	Vitamin D promotes endothelial progenitor cell differentiationand upregulates VEGF.	Vitamin D	0-9	vascular endothelial growth factor A	Homo sapiens	78-82
22495973-14	2012	Patients who needed a supplementation with calcium and vitamin D after PTX preoperatively had higher serum levels of PTH.	Vitamin D	55-64	parathyroid hormone	Homo sapiens	117-120
22434523-0	2012	Vitamin D threshold to prevent aromatase inhibitor-related bone loss: the B-ABLE prospective cohort study.	Vitamin D	0-9	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	31-40
22547098-6	2012	The demonstration that rare variants in CYP27B1, which encodes the enzyme that converts vitamin D to its active form, are strongly associated with MS risk supports a causal role of vitamin D deficiency as a risk factor for MS. SUMMARY: Research on the nature of the association between vitamin D and MS risk and progression continues to progress; however, additional research on the timing and dose-response relationship will be crucial for designing future prevention and treatment trials.	Vitamin D	88-97	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	40-47
22547098-6	2012	The demonstration that rare variants in CYP27B1, which encodes the enzyme that converts vitamin D to its active form, are strongly associated with MS risk supports a causal role of vitamin D deficiency as a risk factor for MS. SUMMARY: Research on the nature of the association between vitamin D and MS risk and progression continues to progress; however, additional research on the timing and dose-response relationship will be crucial for designing future prevention and treatment trials.	Vitamin D	181-190	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	40-47
22547098-6	2012	The demonstration that rare variants in CYP27B1, which encodes the enzyme that converts vitamin D to its active form, are strongly associated with MS risk supports a causal role of vitamin D deficiency as a risk factor for MS. SUMMARY: Research on the nature of the association between vitamin D and MS risk and progression continues to progress; however, additional research on the timing and dose-response relationship will be crucial for designing future prevention and treatment trials.	Vitamin D	181-190	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	40-47
22754549-1	2012	CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH).	Vitamin D	94-103	parathyroid hormone	Homo sapiens	170-189
23781299-1	2012	INTRODUCTION/BACKGROUND: Vitamin D deficiency further increases circulating parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism (pHPT), with potential detrimental effects on bone mass.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	76-95
23781299-1	2012	INTRODUCTION/BACKGROUND: Vitamin D deficiency further increases circulating parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism (pHPT), with potential detrimental effects on bone mass.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	97-100
23781299-9	2012	CONCLUSIONS: Prolonged treatment with vitamin D in various commonly prescribed preparations appeared to be safe and significantly reduced PTH levels by 21%.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	138-141
22454149-2	2012	Because CYP27B1 (1alpha-hydroxylase), the enzyme catalyzing 1,25(OH)(2)D(3) formation in the kidney, is also expressed in extrarenal tissues, we hypothesize that dietary vitamin D(3) will be converted to 25(OH)D(3) in the body and then to 1,25(OH)(2)D(3) locally in the cancer microenvironment in which it will exert autocrine/paracrine anticancer actions.	Vitamin D	170-179	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	8-15
22495973-10	2012	Patients who needed postoperative supplementation with calcium and vitamin D had significantly higher PTH levels.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	102-105
22507651-0	2012	Oral vitamin D effects on PTH levels.	Vitamin D	5-14	parathyroid hormone	Homo sapiens	26-29
22442263-10	2012	CONCLUSIONS: In Australian adults, lower 25(OH)D concentrations were associated with increased MetS risk and higher WC, serum triglyceride, fasting glucose, and insulin resistance at 5 yr. Vitamin D supplementation studies are required to establish whether the link between vitamin D deficiency and MetS is causal.	Vitamin D	189-198	insulin	Homo sapiens	161-168
22180542-5	2012	From skin biopsy specimen messenger RNA (mRNA) expression levels of CYP24A1 and CYP27B1, two enzymes needed for hydroxylation of vitamin D into its active metabolites, and of antimicrobial peptide cathelicidin, were examined.	Vitamin D	129-138	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	80-87
22349668-7	2012	After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p &lt; 0.001).	Vitamin D	32-41	parathyroid hormone	Homo sapiens	335-338
22349668-7	2012	After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p &lt; 0.001).	Vitamin D	32-41	interleukin 6	Homo sapiens	340-344
22349668-7	2012	After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p &lt; 0.001).	Vitamin D	32-41	tumor necrosis factor	Homo sapiens	350-359
22739192-1	2012	This study was aimed to investigate the effect of 1,25(OH)(2) vitamin D(3) [1,25(OH)(2) Vit D(3)] on the differentiation, maturation and function of human dendritic cells (DC) in vitro and its mechanism.	Vitamin D	62-71	vitrin	Homo sapiens	88-91
22676419-6	2012	Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1.	Vitamin D	8-17	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	154-161
22676419-9	2012	Accordingly, we review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D-related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ.	Vitamin D	116-125	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	149-156
22561018-6	2012	When NFkappaB-RAW cells were co-cultured on osteoblastic cells (primary osteoblasts or Kusa O cells) stimulated by osteolytic factors 1,25(OH)(2) vitamin D(3) (1,25(OH)(2)D(3)) and prostaglandin E(2) (PGE(2)), a strong dose dependent signal in NFkappaB-RAW cells was induced.	Vitamin D	146-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	5-13
22328083-0	2012	MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.	Vitamin D	26-35	microRNA 22	Homo sapiens	0-11
22480282-6	2012	Like endogenous osteocalcin whose barely detectable level of expression was dramatically induced by vitamin D(3), the silenced replication of human osteocalcin promoter-directed Ad-hOC-E1 oncolytic adenoviruses loaded in hMSCs was rapidly activated, and the released oncolytic adenoviruses sequentially killed cocultured RCC cells upon vitamin D(3) exposure.	Vitamin D	100-109	bone gamma-carboxyglutamate protein	Homo sapiens	16-27
22480282-6	2012	Like endogenous osteocalcin whose barely detectable level of expression was dramatically induced by vitamin D(3), the silenced replication of human osteocalcin promoter-directed Ad-hOC-E1 oncolytic adenoviruses loaded in hMSCs was rapidly activated, and the released oncolytic adenoviruses sequentially killed cocultured RCC cells upon vitamin D(3) exposure.	Vitamin D	336-345	bone gamma-carboxyglutamate protein	Homo sapiens	148-159
22480282-9	2012	Our results presented the first preclinical demonstration of a novel controllable cell-based gene delivery strategy that combines the advantages of tumor tropism and vitamin D(3)-regulatable human osteocalcin promoter-directed gene expression of hMSCs to improve oncolytic virotherapy for advanced RCC.	Vitamin D	166-175	bone gamma-carboxyglutamate protein	Homo sapiens	197-208
22407786-1	2012	Vitamin D is essential for facilitating calcium absorption and preventing increases in parathyroid hormone (PTH), which can augment bone resorption.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	87-106
21995281-11	2012	CONCLUSION: Our findings suggest that both eGFR and PTH are significantly associated with vitamin D metabolism in men without known CKD.	Vitamin D	90-99	parathyroid hormone	Homo sapiens	52-55
22623742-6	2012	These results identify PTH/PTHrP as a variable that serves to compensate for inadequate vitamin D during activation of antimicrobial peptide production.	Vitamin D	88-97	parathyroid hormone-like peptide	Mus musculus	27-32
22120694-3	2012	The aim of our study was to evaluate some bone mineral metabolism parameters before and after calcium and vitamin D supplementation in NF1 patients.	Vitamin D	106-115	neurofibromin 1	Homo sapiens	135-138
22425169-0	2012	Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.	Vitamin D	0-9	apolipoprotein A5	Homo sapiens	31-36
22387237-1	2012	Homozygous and compound heterozygous mutations in SLC34A3, the gene encoding the sodium-dependent co-transporter NaPi-IIc, cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH), a disorder characterized by renal phosphate-wasting resulting in hypophosphatemia, elevated 1,25(OH)(2) vitamin D levels, hypercalciuria, rickets/osteomalacia, and frequently kidney stones or nephrocalcinosis.	Vitamin D	297-306	solute carrier family 34 member 3	Homo sapiens	50-57
22387237-1	2012	Homozygous and compound heterozygous mutations in SLC34A3, the gene encoding the sodium-dependent co-transporter NaPi-IIc, cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH), a disorder characterized by renal phosphate-wasting resulting in hypophosphatemia, elevated 1,25(OH)(2) vitamin D levels, hypercalciuria, rickets/osteomalacia, and frequently kidney stones or nephrocalcinosis.	Vitamin D	297-306	solute carrier family 34 member 3	Homo sapiens	113-121
22120694-8	2012	In conclusion, NF1 patients may present a mineral bone involvement, with vitamin D deficiency; calcium and vitamin D supplementation is necessary to restore these bone mineral metabolic alterations.	Vitamin D	73-82	neurofibromin 1	Homo sapiens	15-18
22120694-8	2012	In conclusion, NF1 patients may present a mineral bone involvement, with vitamin D deficiency; calcium and vitamin D supplementation is necessary to restore these bone mineral metabolic alterations.	Vitamin D	107-116	neurofibromin 1	Homo sapiens	15-18
22330698-7	2012	In multivariate regression models a significant positive correlation between serum vitamin D levels and the expression of vitamin D-regulated targets, cytochrome P450, family 24, subfamily a (cyp24a) expression by PBMCs (P = .0084, pediatric asthma group only) and serum LL-37 levels (P = .0006 in the pediatric group but P = .0067 in the adult asthma group), was found.	Vitamin D	83-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	151-177
22592096-0	2012	Correlation of increases in 1,25-dihydroxyvitamin D during vitamin D therapy with activation of CD4+ T lymphocytes in HIV-1-infected males.	Vitamin D	42-51	CD4 molecule	Homo sapiens	96-99
22592096-3	2012	We speculated whether supplementation with vitamin D could have an effect on CD4+ T lymphocytes or Tregs in HIV-1-infected males.	Vitamin D	43-52	CD4 molecule	Homo sapiens	77-80
22330698-7	2012	In multivariate regression models a significant positive correlation between serum vitamin D levels and the expression of vitamin D-regulated targets, cytochrome P450, family 24, subfamily a (cyp24a) expression by PBMCs (P = .0084, pediatric asthma group only) and serum LL-37 levels (P = .0006 in the pediatric group but P = .0067 in the adult asthma group), was found.	Vitamin D	83-92	cathelicidin antimicrobial peptide	Homo sapiens	271-276
22330698-7	2012	In multivariate regression models a significant positive correlation between serum vitamin D levels and the expression of vitamin D-regulated targets, cytochrome P450, family 24, subfamily a (cyp24a) expression by PBMCs (P = .0084, pediatric asthma group only) and serum LL-37 levels (P = .0006 in the pediatric group but P = .0067 in the adult asthma group), was found.	Vitamin D	122-131	cathelicidin antimicrobial peptide	Homo sapiens	271-276
22330698-8	2012	An inverse association between vitamin D and serum IgE levels was observed in the pediatric (P = .006) asthma group.	Vitamin D	31-40	immunoglobulin heavy constant epsilon	Homo sapiens	51-54
22330698-12	2012	Vitamin D was also related to IgE levels in children but not in adults.	Vitamin D	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	30-33
22402441-7	2012	Treatment of psoriatic plaques with the vitamin D analog calcipotriol interferes with the S100-mediated positive feedback loop by suppressing the increased production of psoriasin and koebnerisin in psoriatic skin and their Th17-mediated regulation in epidermal keratinocytes.	Vitamin D	40-49	S100 calcium binding protein A1	Homo sapiens	90-94
22130786-2	2012	The persistent increase in circulating parathyroid hormone (PTH) caused by vitamin D insufficiency reduces bone density response to antiresorptive agents in these postmenopausal women.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	39-58
22537736-5	2012	Both bone biomarkers" concentrations increased significantly (p &lt; 0.001 for both of them) after supplementation of vitamin D and it was more predominant for osteocalcin.	Vitamin D	118-127	bone gamma-carboxyglutamate protein	Homo sapiens	160-171
22834880-9	2012	In one study, researchers did not identify an association between vitamin D and GDM but did identify an association between higher vitamin D levels and lower fasting glucose and insulin levels.	Vitamin D	131-140	insulin	Homo sapiens	178-185
22716181-12	2012	A great promise for clinical practice are the structural analogs of vitamin D tested experimentally, which maintain the influence on the immune system, effect of insulin and B cells function, but have suppressed influence on bone and calcium metabolism.	Vitamin D	68-77	insulin	Homo sapiens	162-169
21290129-5	2012	This is the first report of resolution of anti-TNFalpha-induced psoriasiform lesions by high doses of vitamin D(3) in a patient with rheumatoid arthritis and vitamin D deficiency.	Vitamin D	102-111	tumor necrosis factor	Homo sapiens	47-55
21290129-5	2012	This is the first report of resolution of anti-TNFalpha-induced psoriasiform lesions by high doses of vitamin D(3) in a patient with rheumatoid arthritis and vitamin D deficiency.	Vitamin D	158-167	tumor necrosis factor	Homo sapiens	47-55
22480149-0	2012	Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study.	Vitamin D	16-25	estrogen receptor 1	Homo sapiens	66-83
22480149-12	2012	CONCLUSIONS: These data suggest that genetic variants in the vitamin D pathway may be related to the higher prevalence of ER-negative breast cancer in AA women.	Vitamin D	61-70	estrogen receptor 1	Homo sapiens	122-124
22328068-2	2012	Animal and human data indicate that vitamin D suppresses the activity of the renin-angiotensin system and improves endothelial function.	Vitamin D	36-45	renin	Homo sapiens	77-82
22234787-6	2012	RESULTS: The angiogenic to antiangiogenic ratio [PlGF/(sFlt-1 x sEng)] was positively related to intake of vitamin D (r = 0.24), vitamin B(2) (r = 0.25), B(12) (r = 0.20), dietary folate equivalents (r = 0.19), iron (r = 0.19), and zinc (r = 0.19) and negatively related to transfats (r = -0.24).	Vitamin D	107-116	placental growth factor	Homo sapiens	49-53
22350110-3	2012	The aim of this prospective study was to test the effect of vitamin D (cholecalciferol) on the incidence of APR and intensity of pain in women undergoing infusion of zoledronic acid for postmenopausal osteoporosis.	Vitamin D	60-69	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	108-111
21166995-6	2012	Serum vitamin D deficiency (&lt;35.0 nmol L-1) was found in 26% and 25% of male and female, respectively.	Vitamin D	6-15	immunoglobulin kappa variable 1-16	Homo sapiens	42-45
21994008-0	2012	Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation.	Vitamin D	0-9	resistin	Rattus norvegicus	102-110
22497530-5	2012	In this study, we explore the possible association between CRP and key factors pertaining to the vitamin D axis--in particular, VDR gene polymorphisms--in cancer patients with cachexia.	Vitamin D	97-106	C-reactive protein	Homo sapiens	59-62
22075270-0	2012	The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes.	Vitamin D	25-34	renin	Homo sapiens	43-48
22075270-1	2012	Vitamin D has been implicated in the pathophysiology of extraskeletal conditions such as hypertension, kidney disease, and diabetes via its ability to negatively regulate the renin-angiotensin system (RAS).	Vitamin D	0-9	renin	Homo sapiens	175-180
22205755-0	2012	An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway.	Vitamin D	43-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	13-32
22205755-3	2012	We now report a novel CYP3A4-dependent pathway, the 4-hydroxylation of 25-hydroxyvitamin D(3) (25OHD(3)), the induction of which may contribute to drug-induced vitamin D deficiency.	Vitamin D	81-90	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	22-28
22431675-14	2012	Parathyroid hormone levels at 12 months decreased with an increasing dose of vitamin D(3) (P = 0.012).	Vitamin D	77-86	parathyroid hormone	Homo sapiens	0-19
22532985-2	2012	Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).	Vitamin D	68-77	poly(ADP-ribose) polymerase 1	Homo sapiens	268-299
22532985-2	2012	Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).	Vitamin D	68-77	poly(ADP-ribose) polymerase 1	Homo sapiens	301-307
22532985-3	2012	Vitamin D has also been implicated in asthma through its effects on the obesity, bacillus Calmettee Guerin (BCG) vaccination and high vitamin D level, vitamin D supplement, checkpoint protein kinase 1 (Chk1), plasminogen activator inhibitor-1 (PAI-1) and gamma delta T cells (gdT).	Vitamin D	0-9	checkpoint kinase 1	Homo sapiens	173-200
22532985-3	2012	Vitamin D has also been implicated in asthma through its effects on the obesity, bacillus Calmettee Guerin (BCG) vaccination and high vitamin D level, vitamin D supplement, checkpoint protein kinase 1 (Chk1), plasminogen activator inhibitor-1 (PAI-1) and gamma delta T cells (gdT).	Vitamin D	0-9	checkpoint kinase 1	Homo sapiens	202-206
22174023-11	2012	Additionally, FSHR mRNA and cell proliferation were significantly (P &lt; 0.05) increased by vitamin D in both groups.	Vitamin D	93-102	follicle stimulating hormone receptor	Gallus gallus	14-18
22431675-2	2012	OBJECTIVE: To determine the effect of increasing oral doses of vitamin D(3) on serum 25-(OH)D and serum parathyroid hormone (PTH) levels in postmenopausal white women with vitamin D insufficiency (defined as a 25-[OH]D level &lt;=50 nmol/L) in the presence of adequate calcium intake.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	125-128
22433171-7	2012	The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl).	Vitamin D	34-43	component of oligomeric golgi complex 2	Homo sapiens	63-68
22182833-13	2012	Vitamin D may improve insulin sensitivity but mixed results on lipid profile in PCOS have been reported.	Vitamin D	0-9	insulin	Homo sapiens	22-29
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	80-89	thioredoxin interacting protein	Mus musculus	51-56
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	80-89	thioredoxin interacting protein	Mus musculus	70-75
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	80-89	thioredoxin interacting protein	Mus musculus	113-117
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	215-224	thioredoxin interacting protein	Mus musculus	51-56
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	215-224	thioredoxin interacting protein	Mus musculus	70-75
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	215-224	thioredoxin interacting protein	Mus musculus	113-117
22435627-5	2012	The messenger RNA (mRNA) expressions of calcium binding protein (CaBP-9k) and active vitamin D synthesis enzyme (CYP27B1) in the kidney were increased in mice treated with 20 mg BPA.	Vitamin D	85-94	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	113-120
21639815-3	2012	Cross-sectional data have linked tenofovir with higher parathyroid hormone (PTH) concentrations in patients with vitamin D deficiency.	Vitamin D	113-122	parathyroid hormone	Homo sapiens	55-74
22370611-0	2012	Vitamin D deficiency is associated with increased IL-17 and TNFalpha levels in patients with chronic heart failure.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	60-68
22238280-8	2012	It remains to be determined whether in youth with dysglycemia the relationships are different and whether vitamin D optimization enhances insulin sensitivity and beta-cell function.	Vitamin D	106-115	insulin	Homo sapiens	138-145
22393183-9	2012	Improved vitamin D status can result in enhanced macrophage synthesis of 1,25-dihydroxyvitamin D, which increases the synthesis of the antimicrobial peptide cathelicidin (LL-37).	Vitamin D	9-18	cathelicidin antimicrobial peptide	Homo sapiens	171-176
22013980-9	2012	In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling.	Vitamin D	37-46	parathyroid hormone	Homo sapiens	141-144
22232734-2	2012	As this is contrary to an expected inverse association between vitamin D status and cancer, we examined whether vitamin D binding protein (DBP), the primary carrier of vitamin D compounds in circulation, plays a role in this relationship.	Vitamin D	112-121	D-box binding PAR bZIP transcription factor	Homo sapiens	139-142
22232734-9	2012	Simultaneous examination of DBP and 25(OH)D may be important in determining the association of vitamin D with cancer risk.	Vitamin D	95-104	D-box binding PAR bZIP transcription factor	Homo sapiens	28-31
22158745-5	2012	In contrast, coculture of A549 cells with the macrophage-like THP-1 cell line, differentiated with vitamin D, or monocyte-derived macrophages enhanced CXCL8 release.	Vitamin D	99-108	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
22106170-1	2012	Cytochrome P450scc (P450scc) catalyzes the cleavage of the side chain of both cholesterol and the vitamin D(3) precursor, 7-dehydrocholesterol.	Vitamin D	98-107	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-18
22106170-1	2012	Cytochrome P450scc (P450scc) catalyzes the cleavage of the side chain of both cholesterol and the vitamin D(3) precursor, 7-dehydrocholesterol.	Vitamin D	98-107	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	11-18
22106170-2	2012	The aim of this study was to test the ability of human P450scc to metabolize ergosterol, the vitamin D(2) precursor, and define the structure of the major products.	Vitamin D	93-102	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	55-62
22470867-11	2012	There was an inverse correlation between Vitamin D deficiency and serum PTH level.	Vitamin D	41-50	parathyroid hormone	Homo sapiens	72-75
22301548-0	2012	Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1.	Vitamin D	0-9	dual specificity phosphatase 1	Homo sapiens	88-106
22301548-6	2012	Upon vitamin D treatment, the expression of MAPK phosphatase-1 (MKP-1) was significantly upregulated in human monocytes and murine bone marrow-derived macrophages (BMM).	Vitamin D	5-14	dual specificity phosphatase 1	Homo sapiens	44-62
22301548-6	2012	Upon vitamin D treatment, the expression of MAPK phosphatase-1 (MKP-1) was significantly upregulated in human monocytes and murine bone marrow-derived macrophages (BMM).	Vitamin D	5-14	dual specificity phosphatase 1	Homo sapiens	64-69
22301548-7	2012	Increased binding of the vitamin D receptor and increased histone H4 acetylation at the identified vitamin D response element of the murine and human MKP-1 promoters were demonstrated.	Vitamin D	25-34	dual specificity phosphatase 1	Homo sapiens	150-155
22301548-9	2012	Vitamin D inhibition of LPS-induced IL-6 and TNF-alpha production by BMM from MKP-1(-/-) mice was significantly reduced as compared with wild-type mice.	Vitamin D	0-9	interleukin 6	Mus musculus	36-40
22301548-9	2012	Vitamin D inhibition of LPS-induced IL-6 and TNF-alpha production by BMM from MKP-1(-/-) mice was significantly reduced as compared with wild-type mice.	Vitamin D	0-9	tumor necrosis factor	Mus musculus	45-54
22301548-10	2012	In conclusion, this study identified the upregulation of MKP-1 by vitamin D as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages.	Vitamin D	66-75	dual specificity phosphatase 1	Homo sapiens	57-62
22301548-10	2012	In conclusion, this study identified the upregulation of MKP-1 by vitamin D as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages.	Vitamin D	66-75	mitogen-activated protein kinase 14	Homo sapiens	135-138
22301548-10	2012	In conclusion, this study identified the upregulation of MKP-1 by vitamin D as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages.	Vitamin D	104-113	dual specificity phosphatase 1	Homo sapiens	57-62
22301548-10	2012	In conclusion, this study identified the upregulation of MKP-1 by vitamin D as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages.	Vitamin D	104-113	mitogen-activated protein kinase 14	Homo sapiens	135-138
22464806-2	2012	Some studies suggest that vitamin D deficiency may have a role in insulin resistance; thus, the aim of the current study was to determine the effect of vitamin D supplementation on insulin resistance in women with PCOS and a vitamin D deficiency.	Vitamin D	152-161	insulin	Homo sapiens	181-188
21871642-0	2012	Association of vitamin D receptor gene polymorphisms with insulin resistance and response to vitamin D.	Vitamin D	15-24	insulin	Homo sapiens	58-65
21871642-1	2012	The objectives of the study were to determine associations between single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene and insulin resistance and the effects of these SNPs on changes in insulin sensitivity in response to vitamin D supplementation.	Vitamin D	113-122	insulin	Homo sapiens	147-154
21871642-1	2012	The objectives of the study were to determine associations between single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene and insulin resistance and the effects of these SNPs on changes in insulin sensitivity in response to vitamin D supplementation.	Vitamin D	113-122	insulin	Homo sapiens	210-217
21871642-5	2012	Associations between SNP genotypes and responses in insulin sensitivity to vitamin D supplementation (4000 IU vitamin D(3) per day) were also determined for a subset (81) of these women.	Vitamin D	75-84	insulin	Homo sapiens	52-59
21871642-8	2012	Of the 81 subjects who were supplemented with vitamin D, women with the FokI Ff genotype showed a significantly greater improvement in insulin sensitivity (increase of 29.4 [2.9, 38.1]) compared with women with the FokI FF genotype (increase of 2.3 [-11.5, 10.1]).	Vitamin D	46-55	insulin	Homo sapiens	135-142
21871642-11	2012	Genotyping of the VDR gene may provide a predictive measure for insulin resistance in response to vitamin D intervention.	Vitamin D	98-107	insulin	Homo sapiens	64-71
22464806-2	2012	Some studies suggest that vitamin D deficiency may have a role in insulin resistance; thus, the aim of the current study was to determine the effect of vitamin D supplementation on insulin resistance in women with PCOS and a vitamin D deficiency.	Vitamin D	26-35	insulin	Homo sapiens	66-73
22464806-2	2012	Some studies suggest that vitamin D deficiency may have a role in insulin resistance; thus, the aim of the current study was to determine the effect of vitamin D supplementation on insulin resistance in women with PCOS and a vitamin D deficiency.	Vitamin D	152-161	insulin	Homo sapiens	181-188
22464806-3	2012	We hypothesized that vitamin D supplementation would lower the glucose level and insulin resistance in women with PCOS and a vitamin D deficiency.	Vitamin D	21-30	insulin	Homo sapiens	81-88
22120462-7	2012	Patients with vitamin D deficiency had higher BMI (P = 0.014) and insulin resistance (P = 0.023) than those with 25(OH)D &gt;20 ng/ml.	Vitamin D	14-23	insulin	Homo sapiens	66-73
22019791-2	2012	The authors examined vitamin D insufficiency and its association with body mass index (BMI) and insulin resistance.	Vitamin D	21-30	insulin	Homo sapiens	96-103
21845364-2	2012	Vitamin D was originally characterized for its role in calcium homeostasis, and the active form, 1,25-dihydroxyvitamin D (1,25D), can be produced in the kidney by 1alpha-hydroxylation of circulating 25-hydroxyvitamin D catalyzed by the enzyme CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	243-250
22734293-11	2012	All patients who are clinically suspected of VDDR should be checked for serum vitamin D status and questioned for previous vitamin D administration before starting vitamin D therapy.	Vitamin D	78-87	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	45-49
22734293-11	2012	All patients who are clinically suspected of VDDR should be checked for serum vitamin D status and questioned for previous vitamin D administration before starting vitamin D therapy.	Vitamin D	123-132	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	45-49
22734293-11	2012	All patients who are clinically suspected of VDDR should be checked for serum vitamin D status and questioned for previous vitamin D administration before starting vitamin D therapy.	Vitamin D	123-132	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	45-49
22734306-1	2012	Vitamin D-deficient rickets (VDDR) remains an important health problem especially in developing countries.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-33
22144504-0	2012	Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.	Vitamin D	69-78	calcium sensing receptor	Homo sapiens	36-40
22019791-9	2012	Whether vitamin D supplementation can improve insulin resistance must be studied further.	Vitamin D	8-17	insulin	Homo sapiens	46-53
22283781-6	2012	RESULTS: 25(OH)D(3) , which is thought to reflect vitamin D status in the body, was surveyed and found to have a mean value of 16.7 ng/mL.	Vitamin D	50-59	iodothyronine deiodinase 3	Homo sapiens	15-19
22051697-0	2012	Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.	Vitamin D	124-133	cytotoxic and regulatory T cell molecule	Homo sapiens	38-87
22051697-0	2012	Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.	Vitamin D	124-133	cytotoxic and regulatory T cell molecule	Homo sapiens	94-99
22051697-5	2012	RESULTS: We identified 3 common variants in the class I MHC-restricted T cell-associated molecule gene (CRTAM) that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level.	Vitamin D	222-231	cytotoxic and regulatory T cell molecule	Homo sapiens	48-97
22051697-5	2012	RESULTS: We identified 3 common variants in the class I MHC-restricted T cell-associated molecule gene (CRTAM) that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level.	Vitamin D	222-231	cytotoxic and regulatory T cell molecule	Homo sapiens	104-109
22051697-8	2012	Functional studies on cell lines confirmed the interaction of vitamin D and rs2272094 on CRTAM expression.	Vitamin D	62-71	cytotoxic and regulatory T cell molecule	Homo sapiens	89-94
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	solute carrier family 1 member 1	Homo sapiens	220-226
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	plasminogen activator, tissue type	Homo sapiens	308-312
22157764-3	2012	Stimulation of HaCaT skin keratinocytes with exogenous LOXL2 or overexpression of LOXL2 in these cells inhibits their differentiation as manifested by inhibition of calcium or vitamin D-induced involucrin expression.	Vitamin D	176-185	lysyl oxidase like 2	Homo sapiens	55-60
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	coagulation factor II thrombin receptor	Homo sapiens	374-377
21625888-0	2012	High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors.	Vitamin D	19-28	parathyroid hormone	Homo sapiens	111-130
22283404-4	2012	Utilizing the allergic airway disease model of asthma with the experimental allergen ovalbumin (OVA), we examined asthma-like responses 24 h after airway challenge with OVA in adult offspring born to vitamin D(3) -replete and vitamin D(3) -deficient mothers.	Vitamin D	200-209	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	85-94
22283404-4	2012	Utilizing the allergic airway disease model of asthma with the experimental allergen ovalbumin (OVA), we examined asthma-like responses 24 h after airway challenge with OVA in adult offspring born to vitamin D(3) -replete and vitamin D(3) -deficient mothers.	Vitamin D	200-209	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	96-99
22283404-4	2012	Utilizing the allergic airway disease model of asthma with the experimental allergen ovalbumin (OVA), we examined asthma-like responses 24 h after airway challenge with OVA in adult offspring born to vitamin D(3) -replete and vitamin D(3) -deficient mothers.	Vitamin D	200-209	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	169-172
22283404-5	2012	The ability of airway-draining lymph node cells to proliferate and secrete cytokines in response to OVA ex vivo was significantly enhanced by vitamin D(3) deficiency.	Vitamin D	142-151	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	100-103
22157764-3	2012	Stimulation of HaCaT skin keratinocytes with exogenous LOXL2 or overexpression of LOXL2 in these cells inhibits their differentiation as manifested by inhibition of calcium or vitamin D-induced involucrin expression.	Vitamin D	176-185	lysyl oxidase like 2	Homo sapiens	82-87
22157764-5	2012	Surprisingly, a point-mutated form of LOXL2 (LOXL2(Y689F)) lacking enzymatic activity, as well as a LOXL2 deletion mutant lacking the entire catalytic domain, also inhibited calcium or vitamin D-induced up-regulation of involucrin expression, suggesting that the enzymatic activity of LOXL2 is not required for this activity.	Vitamin D	185-194	lysyl oxidase like 2	Homo sapiens	38-43
22157764-5	2012	Surprisingly, a point-mutated form of LOXL2 (LOXL2(Y689F)) lacking enzymatic activity, as well as a LOXL2 deletion mutant lacking the entire catalytic domain, also inhibited calcium or vitamin D-induced up-regulation of involucrin expression, suggesting that the enzymatic activity of LOXL2 is not required for this activity.	Vitamin D	185-194	lysyl oxidase like 2	Homo sapiens	45-50
22157764-5	2012	Surprisingly, a point-mutated form of LOXL2 (LOXL2(Y689F)) lacking enzymatic activity, as well as a LOXL2 deletion mutant lacking the entire catalytic domain, also inhibited calcium or vitamin D-induced up-regulation of involucrin expression, suggesting that the enzymatic activity of LOXL2 is not required for this activity.	Vitamin D	185-194	lysyl oxidase like 2	Homo sapiens	45-50
22157764-5	2012	Surprisingly, a point-mutated form of LOXL2 (LOXL2(Y689F)) lacking enzymatic activity, as well as a LOXL2 deletion mutant lacking the entire catalytic domain, also inhibited calcium or vitamin D-induced up-regulation of involucrin expression, suggesting that the enzymatic activity of LOXL2 is not required for this activity.	Vitamin D	185-194	lysyl oxidase like 2	Homo sapiens	45-50
23208163-1	2012	Recent compelling evidence suggests a role of vitamin D deficiency in the pathogenesis of insulin resistance and insulin secretion derangements, with a consequent possible interference with type 2 diabetes mellitus.	Vitamin D	46-55	insulin	Homo sapiens	90-97
23171504-1	2012	BACKGROUND: Local production of 1,25-dihydroxyvitamin D (1,25(OH)(2)D) regulated by the CYP27B1 enzyme in monocytes contributes to the immunomodulatory effects of vitamin D.	Vitamin D	46-55	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	88-95
23208163-3	2012	In fact, vitamin D deficiency is usually detected in obesity in which insulin resistance is also a common finding.	Vitamin D	9-18	insulin	Homo sapiens	70-77
23208163-5	2012	Some cross-sectional and prospective studies have suggested that vitamin D deficiency may play a role in worsening insulin resistance; others have identified obesity as a risk factor predisposing individuals to exhibit both vitamin D deficiency and insulin resistance.	Vitamin D	65-74	insulin	Homo sapiens	115-122
23208163-8	2012	Although it might seem premature to draw firm conclusions on the role of vitamin D supplementation in reducing insulin resistance and preventing type 2 diabetes, this manuscript will review the circumstances leading to vitamin D deficiency and how such a deficiency can eventually independently affect insulin sensitivity.	Vitamin D	73-82	insulin	Homo sapiens	111-118
22213318-2	2012	Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	163-189
22652727-3	2012	Unfortunately, at least one third of patients on chronic dialysis have high serum P levels, with a consequent higher serum PTH levels, commonly associated with vitamin D deficiency, increased vascular calcification and the highest ratios of morbidity and mortality.	Vitamin D	160-169	parathyroid hormone	Homo sapiens	123-126
22213318-2	2012	Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	191-203
22213318-2	2012	Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	208-215
21619948-8	2012	As well, there may be interactions of EBV and vitamin D with the HLA, In conclusion, using MS as an example, susceptibility for common complex disease most likely results from interactions of genes, environmental interactions and gene/environment interactions.	Vitamin D	46-55	major histocompatibility complex, class II, DR beta 1	Homo sapiens	65-68
22878203-1	2012	Vitamin D(3) initiated rapid extracellular signal-related kinase (ERK) phosphorylation, but the contribution of vitamin D receptor (VDR) to this event is unclear.	Vitamin D	0-9	mitogen-activated protein kinase 1	Homo sapiens	29-64
22878203-1	2012	Vitamin D(3) initiated rapid extracellular signal-related kinase (ERK) phosphorylation, but the contribution of vitamin D receptor (VDR) to this event is unclear.	Vitamin D	0-9	mitogen-activated protein kinase 1	Homo sapiens	66-69
22878203-3	2012	RNAi downregulated VDR as well as its targeted gene expression, but vitamin D(3) dependent ERK phosphorylation remained.	Vitamin D	68-77	mitogen-activated protein kinase 1	Homo sapiens	91-94
23346457-9	2012	Vitamin D deficiency appears to be related to an increase in parathyroid hormone levels and can predispose to essential hypertension and left ventricular hypertrophy, increased insulin resistance, and eventually to atherosclerosis and adverse cardiovascular events.	Vitamin D	0-9	insulin	Homo sapiens	177-184
22352447-4	2012	No well-designed randomised, controlled trials were identified that specifically investigated the effects of vitamin D supplementation on glucose and insulin concentrations.	Vitamin D	109-118	insulin	Homo sapiens	150-157
22414057-5	2012	We consider the biologic evidence in support of a mechanistic contribution of vitamin D insufficiency to insulin resistance and beta-cell dysfunction, the two main pathophysiologic defects underlying T2DM.	Vitamin D	78-87	insulin	Homo sapiens	105-112
22293363-9	2012	Vitamin D supplementation was associated with a decrease in total and non-high-density lipoprotein cholesterol, and an increase in indices of insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	142-149
22293363-10	2012	CONCLUSIONS: Among HIV-infected individuals with vitamin D deficiency, supplementation with 4,000 IU vitamin D3 daily for 12 weeks modestly improved vitamin D status and cholesterol but worsened insulin resistance without change in endothelial function.	Vitamin D	101-110	insulin	Homo sapiens	195-202
22687469-4	2012	In recent years, however, significant progress has been made in the X-ray crystallographic analysis of mammalian CYP enzymes involved in the steroid hormone and vitamin D(3) metabolism.	Vitamin D	161-170	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	113-116
21847642-1	2012	Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	203-222
21847642-1	2012	Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	224-227
21847642-1	2012	Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium.	Vitamin D	176-185	parathyroid hormone	Homo sapiens	203-222
21847642-1	2012	Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium.	Vitamin D	176-185	parathyroid hormone	Homo sapiens	224-227
22143249-6	2012	The mechanism underlying the renal and cardiovascular protection involves regulation of multiple signaling pathways by vitamin D including nuclear factor kappaB, Wnt/beta-catenin and the renin-angiotensin system.	Vitamin D	119-128	renin	Homo sapiens	187-192
21977923-0	2012	Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus.	Vitamin D	60-69	insulin	Homo sapiens	95-102
21977923-1	2012	AIM: This study was performed to determine the effect of a single, large, intramuscular injection of vitamin D post-partum on glucose tolerance and insulin resistance in women with gestational diabetes.	Vitamin D	101-110	insulin	Homo sapiens	148-155
22785457-4	2012	In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels.	Vitamin D	99-108	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	169-176
22785457-4	2012	In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels.	Vitamin D	99-108	chromosome 10 open reading frame 88	Homo sapiens	182-190
22744624-0	2012	Effects of vitamin D on insulin resistance in nursing home residents: an interventional study.	Vitamin D	11-20	insulin	Homo sapiens	24-31
23304196-0	2012	MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1alpha,25-Dihydroxyvitamin D(3) in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells.	Vitamin D	29-38	septin 4	Homo sapiens	0-4
22744624-2	2012	The aim of this study was to assess the effect of vitamin D intake on insulin resistance in aged patients.	Vitamin D	50-59	insulin	Homo sapiens	70-77
22744624-11	2012	In this study, vitamin D intake had no significant effect on FPG level (p = 0.9), but it increased the prevalence of insulin resistance significantly (p &lt; 0.001).	Vitamin D	15-24	insulin	Homo sapiens	117-124
22744624-13	2012	Vitamin D intake had no significant effect on FPG level, but it increased the prevalence of insulin resistance significantly.	Vitamin D	0-9	insulin	Homo sapiens	92-99
22153539-2	2012	The aim of this study was to evaluate the relationship between TGF-beta1 levels and vitamin D deficiency.	Vitamin D	84-93	transforming growth factor beta 1	Homo sapiens	63-72
22153539-10	2012	CONCLUSIONS: Results of this study are suggestive of the presence of a significant relationship between TGF-beta and vitamin D deficiency.	Vitamin D	117-126	transforming growth factor beta 1	Homo sapiens	104-112
22153539-11	2012	Increased TGF-beta1 and platelet count may be an early indicator of bone marrow fibrosis in patients with vitamin D deficiency.	Vitamin D	106-115	transforming growth factor beta 1	Homo sapiens	10-19
23304196-7	2012	Based on our in vitro findings, MART-10 could be a promising vitamin D analog for the potential treatment of breast cancer, for example, ER+ patients, to decrease the tumor relapse rate and the side effect on bone caused by antihormone regimens.	Vitamin D	61-70	septin 4	Homo sapiens	32-36
21956833-0	2012	Vitamin D insufficiency is prevalent and vitamin D is inversely associated with parathyroid hormone and calcitriol in pregnant adolescents.	Vitamin D	41-50	parathyroid hormone	Homo sapiens	80-99
22619734-5	2012	Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS).	Vitamin D	0-9	nitric oxide synthase 2	Homo sapiens	263-284
22988423-0	2012	Role of vitamin D in insulin resistance.	Vitamin D	8-17	insulin	Homo sapiens	21-28
22988423-5	2012	Therefore, it has been proposed that vitamin D deficiency plays an important role in insulin resistance resulting in diabetes.	Vitamin D	37-46	insulin	Homo sapiens	85-92
22988423-8	2012	These effects of vitamin D deficiency, either acting in concert or alone, all serve to increase insulin resistance.	Vitamin D	17-26	insulin	Homo sapiens	96-103
22966228-0	2012	The Effect of Puberty on Interaction between Vitamin D Status and Insulin Resistance in Obese Asian-Indian Children.	Vitamin D	45-54	insulin	Homo sapiens	66-73
22966228-13	2012	The relationship between vitamin D status and parameters of insulin kinetics are affected by puberty.	Vitamin D	25-34	insulin	Homo sapiens	60-67
22619734-4	2012	Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor.	Vitamin D	66-75	poly(ADP-ribose) polymerase 1	Homo sapiens	292-321
22619734-4	2012	Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor.	Vitamin D	66-75	poly(ADP-ribose) polymerase 1	Homo sapiens	328-334
22619734-5	2012	Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS).	Vitamin D	0-9	nerve growth factor	Homo sapiens	116-135
22619734-5	2012	Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS).	Vitamin D	0-9	nerve growth factor	Homo sapiens	137-140
22619734-5	2012	Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS).	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	202-218
22619734-5	2012	Vitamin D has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), nerve growth factor (NGF), matrix metalloproteinases (MMPs), prostaglandins (PGs) and cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS).	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-225
22988423-9	2012	Although there is evidence to support a relationship between vitamin D status and insulin resistance, the underlying mechanism requires further exploration.	Vitamin D	61-70	insulin	Homo sapiens	82-89
22988423-10	2012	The purpose of this paper was to review the current information available concerning the role of vitamin D in insulin resistance.	Vitamin D	97-106	insulin	Homo sapiens	110-117
22347618-3	2012	Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response.	Vitamin D	143-152	insulin	Homo sapiens	100-107
21606669-2	2012	AIM: We sought to define skeletal-related vitamin D sufficiency by estimating maximum PTH suppression in the U.S. population.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	86-89
21606669-11	2012	CONCLUSIONS: Optimal vitamin D status, defined by estimated maximum PTH suppression, does not occur until at least 25OHD levels &gt;=40 ng/ml.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	68-71
23426842-0	2012	The true relation between vitamin D and insulin sensitivity: is it easy to establish?	Vitamin D	26-35	insulin	Homo sapiens	40-47
22001128-9	2012	The cancer protection often associated with high-normal vitamin D status may be attributable, in part, to the ability of the activated vitamin D receptor to decrease cox-2 expression while promoting PGE2 catabolism and suppressing the expression of PGE2 receptors.	Vitamin D	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-171
21816760-4	2012	We also examined epistatic interactions between the VDR SNPs rs731236 and rs2228570 with the tagging single nucleotide polymorphism (SNP) rs3135388 for the HLA-DRB*1501 locus containing a highly conserved vitamin D responsive element within its promoter region.	Vitamin D	205-214	major histocompatibility complex, class II, DR beta 1	Homo sapiens	156-163
23548800-12	2012	CONCLUSION: Vitamin D analogues maintain and, furthermore, re-activate the expression of specialized components of podocytes including podocalyxin, hence they provide protection against loss of the permselective renal barrier, with molecular mechanisms elucidated herein.	Vitamin D	12-21	podocalyxin like	Homo sapiens	135-146
22966878-0	2012	Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients.	Vitamin D	0-9	Wnt family member 5A	Homo sapiens	75-78
22028071-10	2012	Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 beta.	Vitamin D	14-23	C-C motif chemokine ligand 11	Homo sapiens	142-149
22570955-3	2012	The aim of this study was to investigate the relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents.	Vitamin D	57-66	insulin	Homo sapiens	95-102
22570955-12	2012	Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance.	Vitamin D	4-13	insulin	Homo sapiens	171-178
21934326-7	2012	RESULTS: Lower serum vitamin D levels were found to be associated with prehypertension independent of potential confounders including body mass index (BMI), serum cholesterol, C-reactive protein and estimated glomerular filtration rate.	Vitamin D	21-30	C-reactive protein	Homo sapiens	176-194
22079551-1	2012	Cytochrome P450 family 4 (CYP4) proteins metabolize fatty acids, eicosanoids, and vitamin D and are important for chemical defense.	Vitamin D	82-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-24
22079551-1	2012	Cytochrome P450 family 4 (CYP4) proteins metabolize fatty acids, eicosanoids, and vitamin D and are important for chemical defense.	Vitamin D	82-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-30
21760630-11	2012	Since lower levels of 25(OH)D and adiponectin are associated with higher cardio-metabolic risk, assessing the effect of vitamin D supplementation on adiponectin levels is warranted.	Vitamin D	120-129	adiponectin, C1Q and collagen domain containing	Homo sapiens	149-160
22966878-7	2012	These results suggest that vitamin D and other dietary/lifestyle factors may alter CRC risk by mediating extracellular Wnt inhibition.	Vitamin D	27-36	Wnt family member 5A	Homo sapiens	119-122
22347618-5	2012	Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation.	Vitamin D	78-87	insulin	Homo sapiens	134-141
22848563-0	2012	Vitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles.	Vitamin D	0-9	major histocompatibility complex, class II, DR beta 1	Homo sapiens	41-49
23144765-4	2012	In this pilot study, we examined whether active vitamin D (1,25(OH)(2)D(3) or calcitriol) could modulate the CD46 pathway and restore IL-10 production by CD46-costimulated CD4+ T cells from patients with MS.	Vitamin D	48-57	CD46 molecule	Homo sapiens	109-113
23144765-4	2012	In this pilot study, we examined whether active vitamin D (1,25(OH)(2)D(3) or calcitriol) could modulate the CD46 pathway and restore IL-10 production by CD46-costimulated CD4+ T cells from patients with MS.	Vitamin D	48-57	CD46 molecule	Homo sapiens	154-158
23144810-0	2012	High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover.	Vitamin D	19-28	parathyroid hormone	Homo sapiens	85-104
23029160-5	2012	Taken together, vitamin D-VDRa signaling may stimulate Ca(2+) uptake by upregulating ECaC in zebrafish, thereby clarifying the Ca(2+)-handling function of only a VDR in teleosts.	Vitamin D	16-25	vitamin D receptor a	Danio rerio	26-30
23029160-5	2012	Taken together, vitamin D-VDRa signaling may stimulate Ca(2+) uptake by upregulating ECaC in zebrafish, thereby clarifying the Ca(2+)-handling function of only a VDR in teleosts.	Vitamin D	16-25	vitamin D receptor a	Danio rerio	26-29
22523198-8	2012	Counteracting elevated PTH levels by adequate doses of vitamin D may improve the efficacy of this drug.	Vitamin D	55-64	parathyroid hormone	Homo sapiens	23-26
23144810-1	2012	There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	83-102
22937036-1	2012	BACKGROUND: Conflicting reports support or refute an association between vitamin D deficiency with high levels of parathyroid hormone (PTH) and raised blood pressure or hypertension.	Vitamin D	73-82	parathyroid hormone	Homo sapiens	114-133
22848563-1	2012	Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion.	Vitamin D	0-9	major histocompatibility complex, class II, DR beta 1	Homo sapiens	103-111
22848563-1	2012	Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion.	Vitamin D	144-153	major histocompatibility complex, class II, DR beta 1	Homo sapiens	103-111
22848563-6	2012	Functionality of mutated and canonical VDREs was assessed for its potential to modulate levels of DRB1 gene expression using an in vitro transactivation assay after stimulation with active vitamin D metabolite.	Vitamin D	189-198	major histocompatibility complex, class II, DR beta 1	Homo sapiens	98-102
22536774-8	2012	Measurement of Vitamin D concentrations should also be part of any exploration of calcium/phosphorus metabolism which includes measurement of serum calcium, phosphate and PTH.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	171-174
22866178-3	2012	In this study we performed longitudinal analyses to investigate the impact of vitamin D supplementation on macrophage responses to Mycobacterium tuberculosis (Mtb) lipoprotein (TLR2/1L), in Canadian Dene FN participants compared to Caucasian participants.	Vitamin D	78-87	toll like receptor 2	Homo sapiens	177-181
22866178-8	2012	However, vitamin D supplementation markedly enhanced TLR2/1L-induced responses in MDMs e.g. IL-6, IL-12 and IL-23 among Caucasians but not in the Dene participants.	Vitamin D	9-18	toll like receptor 2	Homo sapiens	53-57
22866178-8	2012	However, vitamin D supplementation markedly enhanced TLR2/1L-induced responses in MDMs e.g. IL-6, IL-12 and IL-23 among Caucasians but not in the Dene participants.	Vitamin D	9-18	interleukin 6	Homo sapiens	92-96
22866178-9	2012	In contrast, after vitamin D supplementation TLR2/1L-induced responses e.g. IL-1beta, IL-8 and IL-12 were significantly reduced in the Dene MDMs.	Vitamin D	19-28	toll like receptor 2	Homo sapiens	45-49
22866178-10	2012	These results indicate that vitamin D supplementation enhanced TLR2/1L-induced innate immune macrophage responses in the Caucasian but not in the Dene participants.	Vitamin D	28-37	toll like receptor 2	Homo sapiens	63-67
22292037-11	2012	These novel mathematical models underline the importance of DBP as a determinant of vitamin D "status" in vivo, with future implications for clinical studies of vitamin D status and supplementation.	Vitamin D	84-93	D-box binding PAR bZIP transcription factor	Homo sapiens	60-63
22292037-11	2012	These novel mathematical models underline the importance of DBP as a determinant of vitamin D "status" in vivo, with future implications for clinical studies of vitamin D status and supplementation.	Vitamin D	161-170	D-box binding PAR bZIP transcription factor	Homo sapiens	60-63
23166493-2	2012	We report here that TLR8 activation in human macrophages induces the expression of the human cathelicidin microbial peptide (CAMP), the vitamin D receptor (VDR) and cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1), which 1alpha-hydroxylates the inactive form of vitamin D, 25-hydroxycholecalciferol, into its biologically active metabolite.	Vitamin D	136-145	toll like receptor 8	Homo sapiens	20-24
23166493-3	2012	Moreover, we demonstrate using RNA interference, chemical inhibitors and vitamin D deficient media that TLR8 agonists inhibit HIV through a vitamin D and CAMP dependent autophagic mechanism.	Vitamin D	73-82	toll like receptor 8	Homo sapiens	104-108
23166493-3	2012	Moreover, we demonstrate using RNA interference, chemical inhibitors and vitamin D deficient media that TLR8 agonists inhibit HIV through a vitamin D and CAMP dependent autophagic mechanism.	Vitamin D	140-149	toll like receptor 8	Homo sapiens	104-108
22536764-7	2012	Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	69-88
22536764-7	2012	Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	90-93
22536770-4	2012	Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25(OH)(2)D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25(OH)D), critically linking overall vitamin D status with cellular anti-tumor actions.	Vitamin D	39-48	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
22536770-4	2012	Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25(OH)(2)D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25(OH)D), critically linking overall vitamin D status with cellular anti-tumor actions.	Vitamin D	149-158	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
22536770-4	2012	Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25(OH)(2)D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25(OH)D), critically linking overall vitamin D status with cellular anti-tumor actions.	Vitamin D	149-158	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
22536373-5	2012	Mice treated with the low vitamin D diet had more calcified lesions and a higher expression of Msx2, Bmp2, and Runx2 in aortic roots than mice fed recommended or high amounts of vitamin D (P&lt;0.001).	Vitamin D	26-35	bone morphogenetic protein 2	Mus musculus	101-105
22509365-1	2012	BACKGROUND: Previous studies have identified that variants in peroxisome proliferator-activated receptor PPAR-delta (PPARD), a target gene of vitamin D, were significantly associated with fasting glucose and insulin sensitivity in European populations.	Vitamin D	142-151	insulin	Homo sapiens	208-215
22292037-6	2012	The iSS model was optimized to 25OHD/1,25(OH)(2)D-mediated in vitro dose-responsive induction of the vitamin D target gene cathelicidin (CAMP) in human monocytes.	Vitamin D	101-110	cathelicidin antimicrobial peptide	Homo sapiens	137-141
22292037-10	2012	Finally, the iSS model was used to compare the efficiency of endogenously synthesized versus exogenously added 1,25(OH)(2)D. Data strongly support the endogenous model as the most viable mode for CAMP induction by vitamin D in vivo.	Vitamin D	214-223	cathelicidin antimicrobial peptide	Homo sapiens	196-200
23304521-8	2012	Among prostate cancer patients, vitamin D levels correlated positively with age (r = 0.12, P &lt; 0.02), and were negatively associated with BMI (r = -0.13, P = 0.003), glucose (r = -0.12, P &lt; 0.007), HbA1C (r = -0.16, P = 0.001), and PTH (r = -0.21; P &lt; 0.0001).	Vitamin D	32-41	parathyroid hormone	Homo sapiens	238-241
22189665-1	2012	Elevation in serum parathyroid hormone (PTH) often accompanies vitamin D deficiency and renal impairment.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	19-38
22189665-1	2012	Elevation in serum parathyroid hormone (PTH) often accompanies vitamin D deficiency and renal impairment.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	40-43
22189665-9	2012	The relation between PTH and vitamin D is complex and may show significant threshold variations, especially when calcium intake, age, and race are considered.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	21-24
21664247-3	2011	PTH enhances vitamin D hydroxylation on carbon 1 in kidney cells thereby allowing the systemic release of 1-25-dihydroxy-vitamin D, which represents the fully active hormone.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	0-3
21723567-9	2011	Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.	Vitamin D	20-29	interleukin 6	Homo sapiens	107-111
22095230-6	2011	Active forms of vitamin D were found to inhibit NF-kappaB activity in nonpigmented cells, while having no effect on pigmented cells.	Vitamin D	16-25	nuclear factor kappa B subunit 1	Homo sapiens	48-57
23303986-0	2012	A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome.	Vitamin D	69-78	insulin	Homo sapiens	43-50
23303986-1	2012	INTRODUCTION: We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS).	Vitamin D	147-156	insulin	Homo sapiens	82-89
21669251-2	2011	This review focuses on the concept that cells in the mammary gland express the vitamin D metabolizing enzyme CYP27B1 which converts the circulating vitamin D metabolite 25D to the active metabolite 1,25D.	Vitamin D	79-88	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	109-116
21669251-2	2011	This review focuses on the concept that cells in the mammary gland express the vitamin D metabolizing enzyme CYP27B1 which converts the circulating vitamin D metabolite 25D to the active metabolite 1,25D.	Vitamin D	148-157	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	109-116
21664249-6	2011	Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1alpha-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	94-101
21664425-4	2011	In particular, induction of the vitamin D-activating enzyme CYP27B1 in monocytes via pathogen recognizing receptors has highlighted an entirely new function for vitamin D as a potent inducer of antibacterial innate immune responses.	Vitamin D	32-41	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	60-67
21664425-4	2011	In particular, induction of the vitamin D-activating enzyme CYP27B1 in monocytes via pathogen recognizing receptors has highlighted an entirely new function for vitamin D as a potent inducer of antibacterial innate immune responses.	Vitamin D	161-170	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	60-67
22360357-3	2011	In addition to enhancing calcium absorption from the intestine and mineralization of the osteoid tissue, vitamin D has many other physiological effects, including neuromodulation, improving muscle strength and coordination, insulin release, immunity and prevention of infections, and curtailing cancer.	Vitamin D	105-114	insulin	Homo sapiens	224-231
22190362-13	2011	CYP27B1 encodes the vitamin D-activating 1-alpha hydroxylase enzyme, and thus a role for vitamin D in MS pathogenesis is strongly implicated.	Vitamin D	20-29	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
22190362-13	2011	CYP27B1 encodes the vitamin D-activating 1-alpha hydroxylase enzyme, and thus a role for vitamin D in MS pathogenesis is strongly implicated.	Vitamin D	89-98	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
21712836-0	2011	Vitamin D and parathyroid hormone in insulin resistance of abdominal obesity: cause or effect?	Vitamin D	0-9	insulin	Homo sapiens	37-44
22129928-2	2011	The present study aimed to quantify the association between vitamin D plasma level, the number of metabolic syndrome components and insulin resistance in Canadians.	Vitamin D	60-69	insulin	Homo sapiens	132-139
22129928-5	2011	Adjusted general linear models were used to estimate the association between vitamin D level and probability of having metabolic syndrome, as well as the association between plasma vitamin D and insulin resistance (homeostasis model assessment for insulin resistance, or HOMA-IR).	Vitamin D	181-190	insulin	Homo sapiens	195-202
22129928-10	2011	CONCLUSION: Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance.	Vitamin D	12-21	insulin	Homo sapiens	108-115
22129928-10	2011	CONCLUSION: Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance.	Vitamin D	12-21	insulin	Homo sapiens	180-187
21963453-1	2011	Previous research has shown that vitamin D could suppress proliferation, migration and invasion of cancers, but the effects of vitamin D may be related to the expression of Snail-1, which could inhibit the expression of the vitamin-D gene receptor (VDR).	Vitamin D	127-136	snail family transcriptional repressor 1	Homo sapiens	173-180
21986503-2	2011	The clinical significance of in vitro findings that vitamin D regulates vascular endothelial growth factor production is unclear.	Vitamin D	52-61	vascular endothelial growth factor A	Homo sapiens	72-106
21700898-1	2011	Vitamin D-dependent rickets type 1 is an autosomal recessive disorder caused by an inactivating mutation of the 25-hydroxyvitamin-D-1alpha-hydroxylase (CYP27B1) gene.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	152-159
21820130-1	2011	OBJECTIVE: To evaluate, in a randomized fashion, the impact of vitamin D supplementation on CD4 count and measures of vitamin D homeostasis in children infected with human immunodeficiency virus (HIV).	Vitamin D	63-72	CD4 molecule	Homo sapiens	92-95
22172835-1	2011	Low vitamin D levels prevalent in patients with chronic kidney disease have been reported to be associated with proteinuria, insulin resistance, and cardiovascular disease.	Vitamin D	4-13	insulin	Homo sapiens	125-132
22172835-3	2011	This study investigated the prevalence and association of vitamin D insufficiency with proteinuria, insulin resistance, and cardiovascular parameters among 95 living donor kidney transplant recipients.	Vitamin D	58-67	insulin	Homo sapiens	100-107
22172835-10	2011	On univariate analysis, proteinuria and i-PTH levels were independent predictors of vitamin D insufficiency (P&lt;.01 and P=.03, respectively).	Vitamin D	84-93	parathyroid hormone	Homo sapiens	42-45
22019806-9	2011	CONCLUSIONS: Patients with ARD had, on average, an increased PTH concentration for any plasma VITD range, suggesting an impaired vitamin D metabolism.	Vitamin D	129-138	parathyroid hormone	Homo sapiens	61-64
22019806-10	2011	Therefore, vitamin D supplementation to ARD patients may be targeted to reach PTH suppression and not simply to obtain VITD concentrations considered optimal in other categories of patients.	Vitamin D	11-20	parathyroid hormone	Homo sapiens	78-81
21963453-2	2011	Snail-1 is overexpressed in osteosarcoma, this study was conducted to determine whether inhibiting Snail-1 could increase the role of vitamin D as an anti- osteosarcoma agent.	Vitamin D	134-143	snail family transcriptional repressor 1	Homo sapiens	99-106
22202127-4	2011	Vitamin D also exerts its effect on AD through nongenomic factors, that is, L-type voltage-sensitive calcium channels, nerve growth factor, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide synthase.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	160-176
22112520-1	2011	BACKGROUND: Polycystic ovary syndrome (PCOS) is frequently associated with hypovitaminosis D. Vitamin D is endowed with pleiotropic effects, including insulin resistance (IR) and apoptotic pathway.	Vitamin D	94-103	insulin	Homo sapiens	151-158
21793032-4	2011	These cells express CYP27B1, the gene encoding for the enzyme responsible for the synthesis of the vitamin D hormonally active metabolite, calcitriol.	Vitamin D	99-108	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	20-27
22218438-1	2011	The vitamin D endocrine system comprises a group of 7-dehydrocholesterol-derived secosteroid molecules, including its active metabolite 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its precursors and other metabolites, its binding protein (DBP) and nuclear receptor (VDR), as well as cytochrome P450 complex enzymes participating in activation and inactivation pathways of those molecules.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	236-239
22616336-10	2011	PTH levels started rising at vitamin D level &lt; 30 ng/ml.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	0-3
21124341-1	2011	Obesity and vitamin D deficiency have both been linked to augmented activity of the tissue renin-angiotensin system (RAS).	Vitamin D	12-21	renin	Homo sapiens	91-96
21777617-5	2011	Therapy with vitamin D in animal models of sepsis improves blood coagulation parameters in disseminated intravascular coagulation and modulates levels of systemic inflammatory cytokines including TNF-alpha and IL-6.	Vitamin D	13-22	tumor necrosis factor	Homo sapiens	196-205
21777617-5	2011	Therapy with vitamin D in animal models of sepsis improves blood coagulation parameters in disseminated intravascular coagulation and modulates levels of systemic inflammatory cytokines including TNF-alpha and IL-6.	Vitamin D	13-22	interleukin 6	Homo sapiens	210-214
22040818-7	2011	To suppress PTH secretion without these potential complications, several vitamin D analogs including paricalcitol, maxacalcitol and doxercalciferol are already in clinical use.	Vitamin D	73-82	parathyroid hormone	Homo sapiens	12-15
21434896-9	2011	CONCLUSIONS: We observed stronger associations of serum 25OHD with insulin sensitivity in overweight than normal weight subjects, suggesting that overweight subjects with hypovitaminosis D may benefit more from vitamin D replacement than normal weight subjects.	Vitamin D	211-220	insulin	Homo sapiens	67-74
21613813-2	2011	Accumulating evidence suggests that vitamin D deficiency may contribute to the development of insulin resistance.	Vitamin D	36-45	insulin	Homo sapiens	94-101
21868377-11	2011	We conclude that Dex increases VDR and vitamin D effects by increasing Vdr de novo transcription in a GR-dependent manner.	Vitamin D	39-48	nuclear receptor subfamily 3 group C member 1	Homo sapiens	102-104
21911059-11	2011	Thus, our findings demonstrate that MART-10 is biologically active in vivo and may be an effective vitamin D analogue for clinical trials to treat prostate cancer.	Vitamin D	99-108	septin 4	Homo sapiens	36-40
22118750-0	2011	The emerging evidence for vitamin D-mediated regulation of apolipoprotein A-I synthesis.	Vitamin D	26-35	apolipoprotein A1	Homo sapiens	59-77
22118750-11	2011	Our objectives are to determine if plasma vitamin D levels correlate with plasma HDLc and apo A-I and, if so, offer speculation as to how apo A-I in the context of high vitamin D levels provides enhanced atheroprotection.	Vitamin D	42-51	apolipoprotein A1	Homo sapiens	90-97
22118750-11	2011	Our objectives are to determine if plasma vitamin D levels correlate with plasma HDLc and apo A-I and, if so, offer speculation as to how apo A-I in the context of high vitamin D levels provides enhanced atheroprotection.	Vitamin D	169-178	apolipoprotein A1	Homo sapiens	138-145
21836631-3	2011	Endogenous osteocalcin mRNA was expressed and further enhanced by vitamin D(3) in all osteosarcoma and prostate cancer cell lines and human osteoblasts, but not in human fibroblasts.	Vitamin D	66-75	bone gamma-carboxyglutamate protein	Homo sapiens	11-22
21724580-5	2011	After 6 months of treatment, in the vitamin D(3) supplementation group, CRP decreased 32% overall (P = 0.11), 37% in men (P = 0.05), and 41% among non-nonsteroidal anti-inflammatory drug (NSAID) users (P = 0.05) relative to placebo.	Vitamin D	36-45	C-reactive protein	Homo sapiens	72-75
21724580-6	2011	In the vitamin D(3) supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1beta 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1beta 27%.	Vitamin D	7-16	tumor necrosis factor	Homo sapiens	43-52
21724580-6	2011	In the vitamin D(3) supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1beta 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1beta 27%.	Vitamin D	7-16	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21724580-6	2011	In the vitamin D(3) supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1beta 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1beta 27%.	Vitamin D	7-16	interleukin 1 beta	Homo sapiens	178-186
21998409-0	2011	Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.	Vitamin D	0-9	interferon gamma	Homo sapiens	26-35
21998409-3	2011	We report that T cells, by the release of interferon-gamma (IFN-gamma), induce autophagy, phagosomal maturation, the production of antimicrobial peptides such as cathelicidin, and antimicrobial activity against Mycobacterium tuberculosis in human macrophages via a vitamin D-dependent pathway.	Vitamin D	265-274	interferon gamma	Homo sapiens	60-69
21998409-4	2011	IFN-gamma induced the antimicrobial pathway in human macrophages cultured in vitamin D-sufficient sera, but not in sera from African-Americans that have lower amounts of vitamin D and who are more susceptible to tuberculosis.	Vitamin D	77-86	interferon gamma	Homo sapiens	0-9
21998409-5	2011	In vitro supplementation of vitamin D-deficient serum with 25-hydroxyvitamin D3 restored IFN-gamma-induced antimicrobial peptide expression, autophagy, phagosome-lysosome fusion, and antimicrobial activity.	Vitamin D	28-37	interferon gamma	Homo sapiens	89-98
21958881-1	2011	Substantial evidence suggests that a large portion of the population have suboptimal levels of vitamin D, which may adversely affect the cardiovascular (CV) system, including increasing levels of parathyroid hormone, activating the renin-angiotensin-aldosterone system, and increasing insulin resistance, thus leading to hypertension and left ventricular hypertrophy, metabolic syndrome/diabetes mellitus, systemic inflammation, and increased risk of atherosclerosis and CV disease events.	Vitamin D	95-104	insulin	Homo sapiens	285-292
21836631-4	2011	The osteocalcin promoter activity was weak even with vitamin D(3) treatment in these osteocalcin-expressing cancers, leading to low E1BDelta55K expression after Surv.m-CRA-OCp infection.	Vitamin D	53-62	bone gamma-carboxyglutamate protein	Homo sapiens	4-15
21836631-4	2011	The osteocalcin promoter activity was weak even with vitamin D(3) treatment in these osteocalcin-expressing cancers, leading to low E1BDelta55K expression after Surv.m-CRA-OCp infection.	Vitamin D	53-62	bone gamma-carboxyglutamate protein	Homo sapiens	85-96
24391410-4	2011	An important aspect of vitamin D pleiotropic effects is the interaction with components of the renin-angiotensin system (RAS).	Vitamin D	23-32	renin	Homo sapiens	95-100
24391410-5	2011	It was demonstrated that vitamin D-null mice have a sustained elevation of renin expression.	Vitamin D	25-34	renin	Homo sapiens	75-80
22155603-9	2011	Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort.	Vitamin D	160-169	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	234-288
24391410-10	2011	An important mechanism is the role of vitamin D as a potent negative endocrine regulator of renin expression.	Vitamin D	38-47	renin	Homo sapiens	92-97
22145146-0	2011	Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study.	Vitamin D	37-46	renin	Homo sapiens	0-5
22338935-2	2011	However, the present study confirmed that the role of vitamin D information of undercarboxylated osteocalcin (UcOC) which we recognized the UcOC at the low level of vitamin D will misinterpretation of the level of vitamin K2.	Vitamin D	54-63	bone gamma-carboxyglutamate protein	Homo sapiens	97-108
21773992-5	2011	Compared with placebo, patients on PTH(1-84) reduced their daily dose of calcium and active vitamin D significantly by 75% and 73%, respectively, without developing hypocalcemia.	Vitamin D	92-101	parathyroid hormone	Homo sapiens	35-38
21773992-9	2011	In conclusion, the need for calcium and active vitamin D is reduced significantly during PTH-RT, whereas plasma calcium and phosphate levels are maintained within the physiologic range.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	89-92
22338935-2	2011	However, the present study confirmed that the role of vitamin D information of undercarboxylated osteocalcin (UcOC) which we recognized the UcOC at the low level of vitamin D will misinterpretation of the level of vitamin K2.	Vitamin D	165-174	bone gamma-carboxyglutamate protein	Homo sapiens	97-108
21807617-8	2011	Vitamin D deficient male and female offspring had a 10-fold lower serum 25-hydroxyvitamin D (P &lt; 0.0001) and markedly elevated blood pressures (11-20 mmHg, P &lt; 0.001) and heart rates (21-40 beats min(-1), P &lt; 0.02) than control fed offspring.	Vitamin D	0-9	CD59 molecule (CD59 blood group)	Homo sapiens	202-208
21844150-2	2011	Vitamin D binding protein (DBP) is a highly polymorphic protein that transports vitamin D and its metabolites.	Vitamin D	80-89	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
21832985-2	2011	In this prospective observational study we determined whether nutritional vitamin D repletion can have additional beneficial effects in patients with type 2 diabetic nephropathy already established on renin-angiotensin-aldosterone system inhibition.	Vitamin D	74-83	renin	Homo sapiens	201-206
21832985-8	2011	Thus, in the short term, dietary vitamin D repletion with cholecalciferol had a beneficial effect in delaying the progression of diabetic nephropathy above that due to established renin-angiotensin-aldosterone system inhibition.	Vitamin D	33-42	renin	Homo sapiens	180-185
21586442-7	2011	Patients with vitamin D deficiency also had higher mean (SD) serum IFNalpha activity than patients without vitamin D deficiency (3.5 (6.6) vs 0.3 (0.3); p=0.02).	Vitamin D	14-23	interferon alpha 1	Homo sapiens	67-75
21550088-8	2011	We also demonstrate correlations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women.	Vitamin D	36-45	C-reactive protein	Homo sapiens	90-108
21550088-8	2011	We also demonstrate correlations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women.	Vitamin D	170-179	C-reactive protein	Homo sapiens	90-108
22010421-5	2011	The drug-induced activation of the pregnane X receptor (PXR) is likely to enhance CYP24 expression and the catabolism of 25(OH)D, leading to vitamin D deficiency.	Vitamin D	141-150	nuclear receptor subfamily 1 group I member 2	Homo sapiens	35-54
22010421-5	2011	The drug-induced activation of the pregnane X receptor (PXR) is likely to enhance CYP24 expression and the catabolism of 25(OH)D, leading to vitamin D deficiency.	Vitamin D	141-150	nuclear receptor subfamily 1 group I member 2	Homo sapiens	56-59
21901702-17	2011	One study using vitamin D with insulin showed steady fasting C-peptide levels in the vitamin D group but declining fasting C-peptide levels (368 to 179 pmol/L, P = 0.006) in the insulin alone group at 12 months follow-up.	Vitamin D	85-94	insulin	Homo sapiens	31-38
21901702-21	2011	One study showed that vitamin D with insulin may protect pancreatic beta cells in LADA.	Vitamin D	22-31	insulin	Homo sapiens	37-44
21345709-1	2011	AIMS: In-vitro and observational studies have established a link between vitamin D deficiency and different type 2 diabetes outcomes (insulin resistance, insulin secretion, glucose intolerance).	Vitamin D	73-82	insulin	Homo sapiens	134-141
21345709-2	2011	Although the number of randomized controlled trials vs placebo is small, vitamin D (VTD) has been shown to prevent increases in glucose concentration and insulin resistance, enhance insulin sensitivity and reduce systolic blood pressure in type 2 diabetic patients.	Vitamin D	73-82	insulin	Homo sapiens	154-161
21345709-2	2011	Although the number of randomized controlled trials vs placebo is small, vitamin D (VTD) has been shown to prevent increases in glucose concentration and insulin resistance, enhance insulin sensitivity and reduce systolic blood pressure in type 2 diabetic patients.	Vitamin D	73-82	insulin	Homo sapiens	182-189
21659554-0	2011	APOE epsilon4 is associated with higher vitamin D levels in targeted replacement mice and humans.	Vitamin D	40-49	apolipoprotein E	Mus musculus	0-4
21677063-1	2011	Cytochrome P450scc (CYP11A1) can hydroxylate vitamin D(3), producing 20S-hydroxyvitamin D(3) [20(OH)D(3)] and 20S,23-dihydroxyvitamin D(3) [20,23(OH)(2)D(3)] as the major metabolites.	Vitamin D	45-54	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-18
21677063-1	2011	Cytochrome P450scc (CYP11A1) can hydroxylate vitamin D(3), producing 20S-hydroxyvitamin D(3) [20(OH)D(3)] and 20S,23-dihydroxyvitamin D(3) [20,23(OH)(2)D(3)] as the major metabolites.	Vitamin D	45-54	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	20-27
21677063-4	2011	In the current study, we have further analyzed the reaction products from cytochrome P450scc (P450scc) action on vitamin D(3) and have identified two 22-hydroxy derivatives as products, 22-hydroxyvitamin D(3) [22(OH)D(3)] and 20S,22-dihydroxyvitamin D(3) [20,22(OH)(2)D(3)].	Vitamin D	113-122	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	74-92
21677063-4	2011	In the current study, we have further analyzed the reaction products from cytochrome P450scc (P450scc) action on vitamin D(3) and have identified two 22-hydroxy derivatives as products, 22-hydroxyvitamin D(3) [22(OH)D(3)] and 20S,22-dihydroxyvitamin D(3) [20,22(OH)(2)D(3)].	Vitamin D	113-122	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	85-92
21677063-13	2011	Thus, we have identified 22(OH)D(3) and 20,22(OH)(2)D(3) as products of CYP11A1 action on vitamin D(3) and shown that, like 20(OH)D(3) and 20,23(OH)(2)D(3), they are active on keratinocytes via the VDR, however, showing a degree of phenotypic heterogeneity in comparison with other P450scc-derived hydroxy metabolites of vitamin D(3).	Vitamin D	90-99	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	72-79
21659554-3	2011	One hypothesis proposes that the APOE epsilon4 allele protects against vitamin D deficiency.	Vitamin D	71-80	apolipoprotein E	Mus musculus	33-37
21659554-4	2011	Here we present, for the first time, experimental and epidemiological evidence that the APOE epsilon4 allele is indeed associated with higher serum vitamin D [25(OH)D] levels.	Vitamin D	148-157	apolipoprotein E	Mus musculus	88-92
20671418-0	2011	Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	41-69
21852584-2	2011	Several recent studies also demonstrate negative regulation of the renin gene by vitamin D.	Vitamin D	81-90	renin	Homo sapiens	67-72
21590741-0	2011	The renin-angiotensin system, blood pressure, and heart structure in patients with hereditary vitamin D-resistance rickets (HVDRR).	Vitamin D	94-103	renin	Homo sapiens	4-9
20671418-1	2011	OBJECTIVE: The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGFI concentrations in healthy subjects.	Vitamin D	56-65	insulin like growth factor 1	Homo sapiens	100-104
21872805-1	2011	In chronic kidney disease (CKD), abnormalities in vitamin D metabolism contribute to the development of mineral and skeletal disorders, elevations in parathyroid hormone (PTH), hypertension, systemic inflammation, renal and cardiovascular damage.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	150-169
22783643-3	2011	A review of human, animal, and cellular studies demonstrates conflicting evidence that a low serum vitamin D level is linked to the cause of obesity, hyperlipidemia, hypertension, and insulin resistance.	Vitamin D	99-108	insulin	Homo sapiens	184-191
21832969-9	2011	CONCLUSION: Our study adds DBP to the list of potential genes that contribute to the complex genetic etiology of IBD, and further emphasizes the association between vitamin D homeostasis and intestinal inflammation.	Vitamin D	165-174	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
21808038-1	2011	NADPH-cytochrome P450 oxidoreductase (CYPOR) is essential for electron donation to microsomal cytochrome P450-mediated monooxygenation in such diverse physiological processes as drug metabolism (approximately 85-90% of therapeutic drugs), steroid biosynthesis, and bioactive metabolite production (vitamin D and retinoic acid metabolites).	Vitamin D	298-307	cytochrome p450 oxidoreductase	Homo sapiens	0-36
21808038-1	2011	NADPH-cytochrome P450 oxidoreductase (CYPOR) is essential for electron donation to microsomal cytochrome P450-mediated monooxygenation in such diverse physiological processes as drug metabolism (approximately 85-90% of therapeutic drugs), steroid biosynthesis, and bioactive metabolite production (vitamin D and retinoic acid metabolites).	Vitamin D	298-307	cytochrome p450 oxidoreductase	Homo sapiens	38-43
21750527-0	2011	A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.	Vitamin D	72-81	BP1	Homo sapiens	31-34
21307778-5	2011	The discovery of the vitamin D hormone functioning as an endocrine inhibitor of the renin-angiotensin system provides an explanation for this association.	Vitamin D	21-30	renin	Homo sapiens	84-89
21860562-0	2011	Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old.	Vitamin D	32-41	bone gamma-carboxyglutamate protein	Homo sapiens	103-114
21697301-9	2011	In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.	Vitamin D	27-36	insulin	Homo sapiens	171-178
21653679-5	2011	Systems biology analyses supported a central role for IL-1alpha in the vitamin D(3) response in PrP/SCs.	Vitamin D	71-80	complement component 4 binding protein alpha	Homo sapiens	96-99
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	166-175	complement component 4 binding protein alpha	Homo sapiens	182-185
21653679-7	2011	These studies establish a system to study the molecular profile of PrP/SC differentiation, proliferation, and senescence, and they point to an important new role for IL-1alpha in vitamin D(3) signaling in PrP/SCs.	Vitamin D	179-188	complement component 4 binding protein alpha	Homo sapiens	205-208
21592821-1	2011	Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua.	Vitamin D	33-42	prolactin	Homo sapiens	133-142
21592821-1	2011	Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua.	Vitamin D	33-42	prolactin	Homo sapiens	144-147
21604088-1	2011	Vitamin D-dependent rickets type 1 (VDDR-I) is caused by mutation in CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-42
21604088-1	2011	Vitamin D-dependent rickets type 1 (VDDR-I) is caused by mutation in CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	69-76
21810512-7	2011	Regular use of aspirin or cyclooxygenase (COX)-2 inhibitors decrease recurrence rates and increase serum vitamin D levels.	Vitamin D	105-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-48
21750527-7	2011	Furthermore, we demonstrate that treatment with vitamin D stabilizes 53BP1 and promotes DNA DSBs repair via inhibition of CTSL, providing an as yet unsuspected link between vitamin D action and DNA repair.	Vitamin D	48-57	cathepsin L	Homo sapiens	122-126
21750527-7	2011	Furthermore, we demonstrate that treatment with vitamin D stabilizes 53BP1 and promotes DNA DSBs repair via inhibition of CTSL, providing an as yet unsuspected link between vitamin D action and DNA repair.	Vitamin D	173-182	cathepsin L	Homo sapiens	122-126
21654390-4	2011	Findings from candidate gene studies have been inconsistent, with some implicating an association with 25(OH)D for loci near the gene encoding the hormonal vitamin D activation enzyme (CYP27B1).	Vitamin D	156-165	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	185-192
21985980-1	2011	Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	82-85
21416506-2	2011	Vitamin D-binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D.	Vitamin D	119-128	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
21985980-3	2011	In different cohorts of patients with P-HPT, vitamin D deficiency has been recently associated with higher PTH levels, larger adenomas, and a more severe phenotype (including osteitis fibrosa cystica) as well as negative post-operative outcomes following parathyroidectomy.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	107-110
20817560-1	2011	OBJECTIVE: Vitamin D may promote cardiovascular health in general population and in chronic kidney disease (CKD) through inhibition of the renin-angiotensin system and anti-inflammatory effects.	Vitamin D	11-20	renin	Homo sapiens	139-144
20817560-13	2011	IL-6 may be an important intermediary between vitamin D deficiency and albuminuria, or vitamin D deficiency may contribute to inflammation and subsequent albuminuria.	Vitamin D	46-55	interleukin 6	Homo sapiens	0-4
21851405-0	2011	Should activated vitamin D be used in patients with end-stage renal disease and low levels of parathyroid hormone?	Vitamin D	17-26	parathyroid hormone	Homo sapiens	94-113
21397021-3	2011	Vitamin D functions in a plethora of cellular processes in skeletal muscle including calcium homeostasis, cell proliferation, cell differentiation, fiber size, prevention of fatty degeneration, protection against insulin resistance and arachidonic acid mobilization.	Vitamin D	0-9	insulin	Homo sapiens	213-220
20300755-11	2011	Serum 25-OH vitamin D levels were significantly negatively correlated with DAS28, CRP, and HAQ (respectively, r = -0.431, P = 0.000, r = -0.276, P = 0.026, and r = -0.267, P = 0.031).	Vitamin D	12-21	C-reactive protein	Homo sapiens	82-85
21558808-0	2011	Vitamin D: a new player in the world of mTOR signaling.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Homo sapiens	40-44
21521263-2	2011	Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking.	Vitamin D	0-9	renin	Homo sapiens	77-82
21789969-12	2011	Lower Vitamin D levels were associated with more allergic disease and elevated serum IgE.	Vitamin D	6-15	immunoglobulin heavy constant epsilon	Homo sapiens	85-88
21184246-7	2011	Vitamin D deficiency in each diagnostic category was as follows: (a) inflammatory joint diseases/connective tissue diseases (IJD/CTD), 69%; (b) soft tissue rheumatism, 77%; (c) osteoarthritis, 62%; (d) non-specific musculoskeletal back pain, 75% and (e) osteoporosis, 71%.	Vitamin D	0-9	CTD	Homo sapiens	129-132
21298577-4	2011	In the past 5 years, many have described an association of vitamin D compounds and cardiovascular health through reduction in blood pressure, reduction in inflammatory biomarkers, improved insulin sensitivity, and reduction in cardiovascular disease complications and death.	Vitamin D	59-68	insulin	Homo sapiens	189-196
21789969-15	2011	In addition, vitamin D deficiency was associated with IgE atopy markers in asthmatic children more than controls.	Vitamin D	13-22	immunoglobulin heavy constant epsilon	Homo sapiens	54-57
21402748-1	2011	OBJECTIVE: Previous studies have suggested that circulating adiponectin concentrations are associated positively with vitamin D and negatively with body mass index (BMI) but have not accounted for the influence of the renin-angiotensin-aldosterone system (RAAS) in this relationship.	Vitamin D	118-127	adiponectin, C1Q and collagen domain containing	Homo sapiens	60-71
21402748-11	2011	Future studies should explore whether vitamin D supplementation increases adiponectin levels in obesity.	Vitamin D	38-47	adiponectin, C1Q and collagen domain containing	Homo sapiens	74-85
21422187-2	2011	In myeloid and airway epithelial cells, the active form of vitamin D(3) [1,25(OH)(2)D(3)] increases the expression and antibacterial activity of LL-37.	Vitamin D	59-68	cathelicidin antimicrobial peptide	Homo sapiens	145-150
21397009-4	2011	Melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induced a sustained activation over time of SOD1 in intact mitochondria, showing a bell-shaped enzyme activation dose response with a threshold at 50nM and a maximum effect at 1muM concentration.	Vitamin D	61-70	superoxide dismutase 1	Homo sapiens	115-119
21366811-3	2011	The present study investigated the vitamin D status of a cohort of kidney-transplanted children and adolescents, and the association between vitamin D status and plasma concentrations of PTH, ionized calcium, and phosphate.	Vitamin D	141-150	parathyroid hormone	Homo sapiens	187-190
20848081-0	2011	Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	84-103
20848081-8	2011	The impact of vitamin D deficiency (25(OH)D &lt;= 20 ng/ml) on PTH levels was modified by race/ethnicity (P for interaction, 0.001).	Vitamin D	14-23	parathyroid hormone	Homo sapiens	63-66
20668935-13	2011	Twenty-one (84.0%) of PD patients with vitamin D deficiency, and 22 (78.6%) PD patients whose 25 (OH)D levels were more than 15 ng/mL have been receiving active vitamin D compounds for parathyroid hormone (PTH) control (P &gt; 0.05).	Vitamin D	161-170	parathyroid hormone	Homo sapiens	185-204
20668935-18	2011	PD patients with hypovitaminosis D are at higher risk of insulin resistance even if they are on treatment with active vitamin D for PTH control.	Vitamin D	118-127	insulin	Homo sapiens	57-64
21595844-4	2011	Significant determinants of poor vitamin D status were female gender, diabetes, high PTH, and high urinary protein (2+ or greater).	Vitamin D	33-42	parathyroid hormone	Homo sapiens	85-88
21171822-6	2011	In addition, neonatal dermal fibroblasts treated with vitamin D(3) expressed alkaline phosphatase, osteocalcin and bone sialoprotein, and deposited mineral, which is consistent with an osteoblastic phenotype.	Vitamin D	54-63	bone gamma-carboxyglutamate protein	Homo sapiens	99-110
21482732-1	2011	The vitamin D-activating enzyme 1alpha-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues.	Vitamin D	4-13	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	52-59
21458521-4	2011	A novel vitamin D response element was identified in intron 1 of the EGFR genome, a known hotspot for its transcriptional regulation.	Vitamin D	8-17	epidermal growth factor receptor	Homo sapiens	69-73
21458521-7	2011	Over expression of an active EGFR in vitamin D sensitive ovarian cancer cells caused resistance to 1,25(OH)(2)D(3)-induced growth suppression and diminished the hormonal regulation of cyclin D1, cyclin E, Skp2 and p27, a group of cell cycle regulators that mediate 1,25(OH)(2)D(3)-induced cell cycle arrest at G1-S checkpoint.	Vitamin D	37-46	epidermal growth factor receptor	Homo sapiens	29-33
21458521-7	2011	Over expression of an active EGFR in vitamin D sensitive ovarian cancer cells caused resistance to 1,25(OH)(2)D(3)-induced growth suppression and diminished the hormonal regulation of cyclin D1, cyclin E, Skp2 and p27, a group of cell cycle regulators that mediate 1,25(OH)(2)D(3)-induced cell cycle arrest at G1-S checkpoint.	Vitamin D	37-46	zinc ribbon domain containing 2	Homo sapiens	214-217
21482732-2	2011	Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ.	Vitamin D	143-152	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	35-42
21287159-0	2011	Role of parathyroid hormone in bone fragility of postmenopausal women with vitamin D insufficiency.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	8-27
21287159-1	2011	Vitamin D insufficiency is related to an increase in PTH, which might be critical for an increase in bone fragility.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	53-56
21287159-9	2011	The proportion of subjects with prevalent fractures was significantly higher in the group with lower PTH and lower 25(OH)D than in the group with lower PTH and higher 25(OH)D or higher PTH and higher 25(OH)D. In conclusion, vitamin D insufficiency was found to be related to prevalent fracture risk independently of PTH.	Vitamin D	224-233	parathyroid hormone	Homo sapiens	101-104
21349923-2	2011	Published in vitro data indicate that vitamin D may up-regulate the expression of the CYP3A4 gene.	Vitamin D	38-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
21349923-4	2011	The aim of the present study was to investigate whether plasma concentrations of CYP3A4 drug substrates exhibit seasonal changes compatible with a stimulatory effect of vitamin D on drug metabolism.	Vitamin D	169-178	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
21329969-2	2011	However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied.	Vitamin D	37-46	immunoglobulin heavy constant epsilon	Homo sapiens	86-89
21389086-0	2011	Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome.	Vitamin D	0-9	insulin	Homo sapiens	50-57
21389086-1	2011	INTRODUCTION: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances including insulin resistance (IR), which might be related to vitamin D metabolism.	Vitamin D	165-174	insulin	Homo sapiens	114-121
21329969-9	2011	CONCLUSION: Vitamin D deficiency is associated with higher levels of IgE sensitization in children and adolescents.	Vitamin D	12-21	immunoglobulin heavy constant epsilon	Homo sapiens	69-72
21521231-5	2011	It will be important to include in the design of these studies selection of insulin-resistant study subjects who have a low (&lt; 50 nmol/L) initial serum vitamin D (25-hydroxyvitamin D) status and administration of sufficient vitamin D to adequately increase their vitamin D status to &gt; 75 nmol/L serum 25-hydroxyvitamin D.	Vitamin D	155-164	insulin	Homo sapiens	76-83
21277123-0	2011	Aromatase inhibitor-induced arthralgia: is vitamin D deficiency responsible?	Vitamin D	43-52	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
21310542-3	2011	In this article we explore how vitamin D may promote VGEF, IGF-1 and axonal regeneration delaying ALS progression.	Vitamin D	31-40	insulin like growth factor 1	Homo sapiens	59-64
21323790-3	2011	This review discusses potential mechanisms identified in the basic science literature that may provide important insights into how vitamin D may orchestrate a change in cardiovascular risk profile through such diverse mechanisms as inflammation, atherogenesis, glucose homeostasis, vascular calcification, renin-angiotensin regulation and alterations in cardiac physiology.	Vitamin D	131-140	renin	Homo sapiens	306-311
21521231-5	2011	It will be important to include in the design of these studies selection of insulin-resistant study subjects who have a low (&lt; 50 nmol/L) initial serum vitamin D (25-hydroxyvitamin D) status and administration of sufficient vitamin D to adequately increase their vitamin D status to &gt; 75 nmol/L serum 25-hydroxyvitamin D.	Vitamin D	176-185	insulin	Homo sapiens	76-83
21521231-5	2011	It will be important to include in the design of these studies selection of insulin-resistant study subjects who have a low (&lt; 50 nmol/L) initial serum vitamin D (25-hydroxyvitamin D) status and administration of sufficient vitamin D to adequately increase their vitamin D status to &gt; 75 nmol/L serum 25-hydroxyvitamin D.	Vitamin D	176-185	insulin	Homo sapiens	76-83
21606712-0	2011	Protean manifestations of vitamin D deficiency, part 2: deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes.	Vitamin D	26-35	insulin	Homo sapiens	153-160
21606712-5	2011	Due mainly to increased insulin resistance but also to an impairment in insulin release, vitamin D deficiency is associated with the development of type 2 diabetes.	Vitamin D	89-98	insulin	Homo sapiens	24-31
21606713-1	2011	Vitamin D deficiency is associated with the risk factors of inflammation, insulin resistance and endothelial dysfunction, and left ventricular hypertrophy.	Vitamin D	0-9	insulin	Homo sapiens	74-81
21289245-7	2011	RESULTS: We observed that TGF-beta3 induced fibronectin and collagen type 1 protein expression in HuLM cells, and that effect was suppressed by vitamin D(3).	Vitamin D	144-153	fibronectin 1	Homo sapiens	44-55
21420936-1	2011	1alpha,25-dihydroxyvitamin D(3) (calcitriol), the bioactive metabolite of vitamin D, modulates the activation and inhibits IgE production of anti-CD40 and IL-4 stimulated human peripheral B cells.	Vitamin D	19-28	interleukin 4	Homo sapiens	155-159
21121929-1	2011	BACKGROUND: 1alpha,25-dihydroxyvitamin D(3) (calcitriol), the biologically active form of vitamin D, is an immunomodulatory hormone, e.g. it inhibits IgE synthesis in B cells.	Vitamin D	31-40	immunoglobulin heavy constant epsilon	Homo sapiens	150-153
21156217-5	2011	In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p&lt;0.001), IL-23 (p=0.011), IL-10 (p=0.033) cytokine levels, TM (p=0.001) and endothelin (p=0.033) levels.	Vitamin D	26-35	interleukin 6	Homo sapiens	80-84
21156217-6	2011	Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p&lt;0.001), fibrinogen (p=0.010), total cholesterol (p=0.042) and ApoA1 (p=0.004) levels.	Vitamin D	4-13	fibrinogen beta chain	Homo sapiens	113-123
21156217-6	2011	Low vitamin D levels were also significantly associated with carotid artery intima media thickness (p&lt;0.001), fibrinogen (p=0.010), total cholesterol (p=0.042) and ApoA1 (p=0.004) levels.	Vitamin D	4-13	apolipoprotein A1	Homo sapiens	167-172
21524245-7	2011	Treatment with vitamin D in PHPT may decrease PTH levels and bone turnover and potentially increase bone mass in various compartments.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	46-49
21524245-11	2011	Vitamin D treatment is recommended and may decrease PTH levels in PHPT.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	52-55
19482377-3	2011	Vitamin D deficient (VitD-deficient) animals showed elevated inflammatory proteins (TNFalpha, IL-1beta, IL-6, NFkappaB p65) in the brain even without injury.	Vitamin D	0-9	tumor necrosis factor	Rattus norvegicus	84-92
19482377-3	2011	Vitamin D deficient (VitD-deficient) animals showed elevated inflammatory proteins (TNFalpha, IL-1beta, IL-6, NFkappaB p65) in the brain even without injury.	Vitamin D	0-9	interleukin 1 beta	Rattus norvegicus	94-102
19482377-3	2011	Vitamin D deficient (VitD-deficient) animals showed elevated inflammatory proteins (TNFalpha, IL-1beta, IL-6, NFkappaB p65) in the brain even without injury.	Vitamin D	0-9	interleukin 6	Rattus norvegicus	104-108
19482377-3	2011	Vitamin D deficient (VitD-deficient) animals showed elevated inflammatory proteins (TNFalpha, IL-1beta, IL-6, NFkappaB p65) in the brain even without injury.	Vitamin D	0-9	synaptotagmin 1	Rattus norvegicus	119-122
22375372-0	2011	[Importance of vitamin D in insulin resistance].	Vitamin D	15-24	insulin	Homo sapiens	28-35
22468040-8	2011	Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients.	Vitamin D	132-141	epidermal growth factor receptor	Homo sapiens	6-11
22468040-8	2011	Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients.	Vitamin D	132-141	epidermal growth factor receptor	Homo sapiens	153-171
22468040-9	2011	This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD.	Vitamin D	118-127	epidermal growth factor receptor	Homo sapiens	75-93
22468040-9	2011	This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD.	Vitamin D	118-127	fibrinogen beta chain	Homo sapiens	186-206
21289245-8	2011	TGF-beta3 also induced protein expression of plasminogen activator inhibitor-1, an important TGF-beta target, in HuLM cells, which was also inhibited by vitamin D(3).	Vitamin D	153-162	transforming growth factor beta 1	Homo sapiens	0-8
21350098-7	2011	There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFkappaB activity, and TLR4 expression (P &lt; .05).	Vitamin D	53-62	C-reactive protein	Homo sapiens	91-109
21350098-7	2011	There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFkappaB activity, and TLR4 expression (P &lt; .05).	Vitamin D	53-62	nuclear factor kappa B subunit 1	Homo sapiens	111-119
21209228-0	2011	Will vitamin D reduce insulin resistance?	Vitamin D	5-14	insulin	Homo sapiens	22-29
21303875-8	2011	Urine calcium concentration was 26% lower and serum parathyroid hormone (PTH) was 27% higher in patients with vitamin D deficiency when compared with patients without vitamin D deficiency.	Vitamin D	110-119	parathyroid hormone	Homo sapiens	52-71
21228264-11	2011	At 9.5 y, children of vitamin D-deficient mothers had higher fasting insulin resistance than did children of nondeficient women (P = 0.04).	Vitamin D	22-31	insulin	Homo sapiens	69-76
20957441-0	2011	The value of postoperative parathyroid hormone levels in predicting the need for long-term vitamin D supplementation after total thyroidectomy.	Vitamin D	91-100	parathyroid hormone	Homo sapiens	27-46
21181400-10	2011	In conclusion, PTH levels in the upper part or above the upper level of the reference interval increase risk of fracture in the presence of low vitamin D levels.	Vitamin D	144-153	parathyroid hormone	Homo sapiens	15-18
21454240-2	2011	METHODS: A review of the literature was undertaken regarding the function and metabolism of vitamin D; the role of the vitamin D receptor and calcium-sensing receptor in the secretion of parathyroid hormone; and the contemporary research regarding the interaction of vitamin D and parathyroid hormone in patients with vitamin D deficiency, primary hyperparathyroidism, and secondary hyperparathyroidism.	Vitamin D	119-128	parathyroid hormone	Homo sapiens	187-206
21273498-0	2011	Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States.	Vitamin D	39-48	insulin	Homo sapiens	71-78
21273498-1	2011	OBJECTIVE: Our objective was to examine the associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA(1c) in a nationally representative sample of adolescents in the U.S. RESEARCH DESIGN AND METHODS: We used data for 1,941 adolescents, aged 12-17 years, who participated in the National Health and Nutrition Examination Survey between 2001 and 2006.	Vitamin D	83-92	insulin	Homo sapiens	115-122
21273498-5	2011	CONCLUSIONS: Our results support an inverse association between concentrations of vitamin D and insulin primarily in adolescent male subjects.	Vitamin D	82-91	insulin	Homo sapiens	96-103
21454240-2	2011	METHODS: A review of the literature was undertaken regarding the function and metabolism of vitamin D; the role of the vitamin D receptor and calcium-sensing receptor in the secretion of parathyroid hormone; and the contemporary research regarding the interaction of vitamin D and parathyroid hormone in patients with vitamin D deficiency, primary hyperparathyroidism, and secondary hyperparathyroidism.	Vitamin D	119-128	parathyroid hormone	Homo sapiens	187-206
21454240-3	2011	RESULTS: Over the last several years, great interest has been generated about the interaction of vitamin D and the parathyroid glands, gastrointestinal tract, kidney, and bone in relation to calcium and parathyroid hormone levels.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	203-222
21454240-4	2011	Vitamin D has an important role in calcium and parathyroid hormone metabolism.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	47-66
21242105-6	2011	Though vitamin D"s anti-viral mechanism has not been fully established, it may be linked to vitamin D"s ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2.	Vitamin D	7-16	cathelicidin antimicrobial peptide	Homo sapiens	155-160
21122842-8	2011	RESULT(S): A high vitamin D level was unexpectedly associated with lower crude median total sperm count and percentage of normal morphology sperm and a high level of crude median sex hormone-binding globulin and FSH.	Vitamin D	18-27	sex hormone binding globulin	Homo sapiens	179-207
21123297-0	2011	Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.	Vitamin D	22-31	mechanistic target of rapamycin kinase	Homo sapiens	108-112
21123297-0	2011	Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.	Vitamin D	84-93	mechanistic target of rapamycin kinase	Homo sapiens	108-112
21123297-8	2011	DDIT4, an inhibitor of mTOR signaling, is a direct target for 1,25(OH)(2)D(3) and VDRE-BP, and functions to suppress cell proliferation in response to vitamin D.	Vitamin D	151-160	mechanistic target of rapamycin kinase	Homo sapiens	23-27
21177785-12	2011	CONCLUSION: D3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2.	Vitamin D	149-158	iodothyronine deiodinase 3	Homo sapiens	12-14
21177785-14	2011	Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency.	Vitamin D	102-111	iodothyronine deiodinase 3	Homo sapiens	42-44
21242105-6	2011	Though vitamin D"s anti-viral mechanism has not been fully established, it may be linked to vitamin D"s ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2.	Vitamin D	92-101	cathelicidin antimicrobial peptide	Homo sapiens	155-160
21042807-3	2011	Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been found to influence vitamin D levels.	Vitamin D	63-72	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
21042807-3	2011	Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been found to influence vitamin D levels.	Vitamin D	150-159	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
21042807-3	2011	Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been found to influence vitamin D levels.	Vitamin D	150-159	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115
20683712-3	2011	Vitamin D supplementation was more effective than advised sunlight exposure in improving vitamin D status and lowering parathyroid hormone levels.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	119-138
20354914-2	2011	Vitamin A modulates in vitro differentiation of islet cells and vitamin D affects beta-cell insulin secretion, while both vitamin ligands act through heterodimerization with the retinoid X receptor (RXR).	Vitamin D	64-73	insulin	Homo sapiens	92-99
20585939-11	2011	CONCLUSIONS: In postmenopausal minority women, vitamin D deficiency was highly prevalent and associated with AA race and lack of supplement use, as well as lower current CD4 cell count.	Vitamin D	47-56	CD4 molecule	Homo sapiens	170-173
21326359-4	2011	WSTF function includes chromatin assembly, RNA polymerase I and III gene regulation, vitamin D metabolism, and DNA repair.	Vitamin D	85-94	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	0-4
21091810-1	2011	OBJECTIVES: the results of experimental studies suggest that vitamin D deficiency activates the renin-angiotensin system and predisposes to hypertension.	Vitamin D	61-70	renin	Homo sapiens	96-101
21178079-1	2011	Epidemiological studies report inverse associations between blood vitamin D, as measured by 25-hydroxyvitamin D [25(OH)D] concentrations, and insulin resistance (IR) among predominantly overweight individuals.	Vitamin D	66-75	insulin	Homo sapiens	142-149
21164021-4	2011	Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene.	Vitamin D	94-103	parathyroid hormone	Homo sapiens	140-143
21164021-4	2011	Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene.	Vitamin D	94-103	parathyroid hormone	Homo sapiens	288-291
20876154-0	2011	Multiple sclerosis in a patient with membranous glomerulopathy: is vitamin D deficiency the culprit in the presence of HLA DRB1*1501 allele?	Vitamin D	67-76	major histocompatibility complex, class II, DR beta 1	Homo sapiens	119-127
21304967-11	2011	Among vaccinees, there was also a strong inverse association between IFNgamma response to M.tb PPD and vitamin D concentration, with infants with higher vitamin D concentrations having lower IFNgamma responses.	Vitamin D	103-112	interferon gamma	Homo sapiens	69-77
21400943-3	2011	Vitamin D seems to have an inhibitory effect on renin secretion and might by this mechanism exert an antihypertensive effect.	Vitamin D	0-9	renin	Homo sapiens	48-53
21062631-11	2011	SIGNIFICANCE: These results suggest that the vitamin D metabolite 24, 25-(OH)(2)D(3) is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism.	Vitamin D	45-54	apolipoprotein A1	Homo sapiens	115-122
20965147-1	2011	Vitamin D intoxication was produced with oral doses of either vitamin D3 or 25-hydroxyvitamin D3 in CYP27B1 -/- (1alpha-hydroxylase knockout) and wild-type mice.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	100-107
20596035-1	2011	BACKGROUND: Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification.	Vitamin D	42-51	insulin	Homo sapiens	129-136
20868777-1	2011	Vitamin D deficiency may contribute to pathological changes in the number and function of CD4+ T helper cell subsets (CD4+Th1, CD4+Th17, CD4+CD25(bright)Foxp3-natural regulatory T cells-nTreg) in patients with undifferentiated connective tissue disease (UCTD).	Vitamin D	0-9	CD4 molecule	Homo sapiens	90-93
22094836-13	2011	CONCLUSION: Vitamin D supplementation attenuated the increase in glycemia, and increased insulin secretion, but had no effect on insulin resistance.	Vitamin D	12-21	insulin	Homo sapiens	89-96
20868777-1	2011	Vitamin D deficiency may contribute to pathological changes in the number and function of CD4+ T helper cell subsets (CD4+Th1, CD4+Th17, CD4+CD25(bright)Foxp3-natural regulatory T cells-nTreg) in patients with undifferentiated connective tissue disease (UCTD).	Vitamin D	0-9	CD4 molecule	Homo sapiens	118-121
20736132-10	2011	RESULT(S): Vitamin D inhibited the growth of HuLM cells by 47+-0.03% at 1 muM and by 38+-0.02% at 0.1 muM compared with control cells at 120 hours of treatment.	Vitamin D	11-20	latexin	Homo sapiens	74-77
21500723-7	2011	The areas under the ROC curves showed the low accuracy of PTH (0.579), Alk-Ph (0.478), Ca (0.496), and P (0.406) in detecting subjects with a vitamin D concentration &lt; 20 ng/mL.	Vitamin D	142-151	parathyroid hormone	Homo sapiens	58-61
22144216-1	2011	BACKGROUND: There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease.	Vitamin D	46-55	insulin	Homo sapiens	151-158
20736132-14	2011	CONCLUSION(S): Vitamin D inhibits growth of HuLM cells through the down-regulation of PCNA, CDK1, and BCL-2 and suppresses COMT expression and activity in HuLM cells.	Vitamin D	15-24	BCL2 apoptosis regulator	Homo sapiens	102-107
20868777-1	2011	Vitamin D deficiency may contribute to pathological changes in the number and function of CD4+ T helper cell subsets (CD4+Th1, CD4+Th17, CD4+CD25(bright)Foxp3-natural regulatory T cells-nTreg) in patients with undifferentiated connective tissue disease (UCTD).	Vitamin D	0-9	CD4 molecule	Homo sapiens	118-121
20868777-1	2011	Vitamin D deficiency may contribute to pathological changes in the number and function of CD4+ T helper cell subsets (CD4+Th1, CD4+Th17, CD4+CD25(bright)Foxp3-natural regulatory T cells-nTreg) in patients with undifferentiated connective tissue disease (UCTD).	Vitamin D	0-9	CD4 molecule	Homo sapiens	118-121
21307571-4	2011	The active form of vitamin D, 1alpha,25(OH)(2)D(3), derived by vitamin D3 1alpha hydroxylase, 1alpha(OH)ase in renal proximal tubule cells is a ligand for VDR.	Vitamin D	19-28	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	94-107
20795939-6	2011	Specifically, vitamin D is a negative regulator of the hormone renin, the pivotal hormone of the renin-angiotensin system.	Vitamin D	14-23	renin	Homo sapiens	63-68
20795939-6	2011	Specifically, vitamin D is a negative regulator of the hormone renin, the pivotal hormone of the renin-angiotensin system.	Vitamin D	14-23	renin	Homo sapiens	97-102
20736132-10	2011	RESULT(S): Vitamin D inhibited the growth of HuLM cells by 47+-0.03% at 1 muM and by 38+-0.02% at 0.1 muM compared with control cells at 120 hours of treatment.	Vitamin D	11-20	latexin	Homo sapiens	102-105
20736132-11	2011	Vitamin D inhibited extracellular signal-regulated kinase activation and down-regulated the expression of BCL-2, BCL-w, CDK1, and PCNA.	Vitamin D	0-9	BCL2 apoptosis regulator	Homo sapiens	106-111
21697621-0	2011	Vitamin D deficiency and seasonal and inter-day variation in circulating 25-hydroxyvitamin D and parathyroid hormone levels in indoor daytime workers: a longitudinal study.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	97-116
21647319-4	2011	Therefore, vitamin D analogs have been developed, which suppress PTH secretion and synthesis with reduced calcemic and phosphatemic effects.	Vitamin D	11-20	parathyroid hormone	Homo sapiens	65-68
22211018-4	2011	The aim of this study is (1) to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy (alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD.	Vitamin D	301-310	bone gamma-carboxyglutamate protein	Homo sapiens	94-105
21694461-2	2011	Nasal insulin acutely improves cognition and vitamin D upregulates insulin receptor expression and enhances insulin action.	Vitamin D	45-54	insulin	Homo sapiens	67-74
20966550-11	2011	Consequently, prevention of Abeta toxicity which was one of the major component of AD type pathology by vitamin D treatment and understanding how Abeta effects vitamin D related pathways, might open up new frontiers in clarifying molecular mechanisms of neurodegeneration and provide basis for novel perspectives in both preventing and treating AD.	Vitamin D	104-113	amyloid beta precursor protein	Homo sapiens	28-33
20966550-11	2011	Consequently, prevention of Abeta toxicity which was one of the major component of AD type pathology by vitamin D treatment and understanding how Abeta effects vitamin D related pathways, might open up new frontiers in clarifying molecular mechanisms of neurodegeneration and provide basis for novel perspectives in both preventing and treating AD.	Vitamin D	160-169	amyloid beta precursor protein	Homo sapiens	28-33
21694461-2	2011	Nasal insulin acutely improves cognition and vitamin D upregulates insulin receptor expression and enhances insulin action.	Vitamin D	45-54	insulin	Homo sapiens	67-74
22155462-1	2011	OBJECTIVE: To investigate the effects of vitamin D deficiency on both insulin resistance and risk of metabolic syndrome in children.	Vitamin D	41-50	insulin	Homo sapiens	70-77
20567864-0	2011	Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 load in Japanese subjects.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	65-84
21765616-0	2011	Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis.	Vitamin D	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
20563998-0	2011	Vitamin D supplementation and recombinant human erythropoietin utilization in vitamin D-deficient hemodialysis patients.	Vitamin D	78-87	erythropoietin	Homo sapiens	48-62
22308861-2	2011	Studies on type 2 diabetes mellitus (T2DM) have shown that vitamin D increases insulin efficacy; however, there are no studies that define a similar relationship in type 1 diabetes mellitus (T1DM).	Vitamin D	59-68	insulin	Homo sapiens	79-86
22308861-3	2011	The aim of this study was to investigate the relation between serum vitamin D levels and the insulin requirement used in children with T1DM.	Vitamin D	68-77	insulin	Homo sapiens	93-100
22308861-10	2011	There was weak correlation between the daily insulin requirements and serum vitamin D levels (r = -0.212, p = 0.032).	Vitamin D	76-85	insulin	Homo sapiens	45-52
22145480-1	2011	There are two types of vitamin D dependent rickets (VDDR) that cause rickets in children.	Vitamin D	23-32	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	52-56
22145480-2	2011	Vitamin D dependent rickets type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1alpha-hydroxylase.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
22145480-2	2011	Vitamin D dependent rickets type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1alpha-hydroxylase.	Vitamin D	76-85	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
22145480-3	2011	Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR).	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
20714323-0	2011	Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action.	Vitamin D	0-9	insulin	Homo sapiens	38-45
21131424-0	2011	The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.	Vitamin D	4-13	CD4 molecule	Homo sapiens	46-49
22254134-0	2011	Vitamin d deficiency in obese children and its relationship to insulin resistance and adipokines.	Vitamin D	0-9	insulin	Homo sapiens	63-70
21528812-7	2011	CONCLUSIONS: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.	Vitamin D	17-26	adiponectin, C1Q and collagen domain containing	Homo sapiens	54-65
21528812-7	2011	CONCLUSIONS: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.	Vitamin D	17-26	insulin	Homo sapiens	89-96
21765616-5	2011	The amount of IL-8 secreted by NK cells was increased by IL-15 treatment from levels of 88.64 +- 21.5 to 178.9 +- 23.6 Pg/mL and was significantly reduced by 10(-6) M vitamin D(3) to levels of 59.2 +- 16.3 Pg/mL.	Vitamin D	167-176	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
21765616-6	2011	Our results indicate a novel inflammatory crosstalk between NK cells and eosinophils via IL-15/IL-8 axis that can be modulated by vitamin D(3).	Vitamin D	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
22156654-3	2011	Vitamin D administration could be a multitarget stabilizing treatment for AD since vitamin D simultaneously targets several factors leading to neurodegeneration through immunoregulatory, antioxidant and anti-ischemic actions, as well as the regulation of neurotrophic factors, acetylcholine neurotransmitter and clearance of amyloid beta peptide, and the avoidance of hyperparathyroidism.	Vitamin D	0-9	amyloid beta precursor protein	Homo sapiens	325-337
21629267-4	2011	Downregulation of Mgat1 by IL7RA*C and IL2RA*T is opposed by MGAT1 (IV(A)V(T-T)) and vitamin D(3), optimizing branching and mitigating MS risk when combined with enhanced CTLA-4 N-glycosylation by CTLA-4 Thr17.	Vitamin D	85-94	mannoside acetylglucosaminyltransferase 1	Mus musculus	18-23
22156654-3	2011	Vitamin D administration could be a multitarget stabilizing treatment for AD since vitamin D simultaneously targets several factors leading to neurodegeneration through immunoregulatory, antioxidant and anti-ischemic actions, as well as the regulation of neurotrophic factors, acetylcholine neurotransmitter and clearance of amyloid beta peptide, and the avoidance of hyperparathyroidism.	Vitamin D	83-92	amyloid beta precursor protein	Homo sapiens	325-337
20945958-6	2011	Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.	Vitamin D	49-58	insulin	Homo sapiens	132-139
21489355-8	2011	RESULTS: Vitamin D supplementation for 12 months of osteoporosis and low bone mass therapy in children caused a statistically significant increase in concentrations of the hepatic metabolite of vitamin D and a significant reduction in serum PTH levels.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	241-244
20556359-18	2011	CONCLUSION: Supplementation with higher vitamin D dosages (2,000-3,000 IU/day) is required to achieve a relevant increase of 25(OH)D and normalisation of PTH.	Vitamin D	40-49	parathyroid hormone	Homo sapiens	154-157
20688883-6	2010	RESULTS: Higher leptin levels were associated with higher PTH and lower vitamin D levels, and adjustment for vitamin D attenuated the association between leptin and PTH.	Vitamin D	109-118	parathyroid hormone	Homo sapiens	165-168
21777017-0	2011	Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	0-19
21777017-3	2011	This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	55-58
21949809-6	2011	This mechanism is supported by decreased inflammation in Pglyrp3(-/-) mice following in vivo induction of Treg cells by vitamin D or after neutralization of IL-17.	Vitamin D	120-129	peptidoglycan recognition protein 3	Mus musculus	57-64
21351666-3	2011	The best known genes related to bone density have been identified as the genes for the vitamin D, estrogen and calcitonin receptor, LRP5 and LRP6.	Vitamin D	87-96	LDL receptor related protein 5	Homo sapiens	132-136
22216097-7	2011	CONCLUSION: The results from this study suggest that improving vitamin D status may help lower risk of colorectal cancer associated with higher IGF-1/IGFBP-3 ratio or C-peptide levels.	Vitamin D	63-72	insulin like growth factor 1	Homo sapiens	144-149
22216097-7	2011	CONCLUSION: The results from this study suggest that improving vitamin D status may help lower risk of colorectal cancer associated with higher IGF-1/IGFBP-3 ratio or C-peptide levels.	Vitamin D	63-72	insulin	Homo sapiens	167-176
20688883-8	2010	Path analysis indicated that the association of leptin with PTH was mostly mediated through vitamin D, and that the association between leptin and bone turnover was independent of PTH and vitamin D.	Vitamin D	92-101	parathyroid hormone	Homo sapiens	60-63
20850786-10	2010	One year following gastric bypass surgery, 20% of patients with elevated PTH levels had normal Vit D levels.	Vitamin D	95-100	parathyroid hormone	Homo sapiens	73-76
20962148-9	2010	Daily supplementation with 25 mug vitamin D resulted in a mean increase in serum 25(OH)D of 13.3 nmol/L (P &lt; 0.01) but a decrease in fractional Ca absorption of 8.3% (P &lt; 0.05) and no significant change in fasting serum 1,25-dihydroxyvitamin D, parathyroid hormone, net Ca absorption, or Ca skeletal retention.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	251-270
20153625-4	2010	CM (10(-5) M) activated transcription of a luciferase plasmid containing the distal vitamin D responsive element (VDRE) from the human CYP3A4 gene at levels comparable to 1,25D (10(-8) M) in transfected human colon cancer cells (Caco-2).	Vitamin D	84-93	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-141
20138781-5	2010	First randomized trials demonstrate that vitamin D supplementation leads to vasodilatation and suppresses cardiovascular risk markers such as triglycerides and the inflammation marker tumor necrosis factor-alpha.	Vitamin D	41-50	tumor necrosis factor	Homo sapiens	184-211
21483558-1	2010	Over the past 2 years there has been a radical change in standard clinical practice with respect to vitamin D.	Vitamin D	100-109	EH domain containing 2	Homo sapiens	9-15
21076451-0	2010	Increased fetuin-A levels following treatment with a vitamin D analog.	Vitamin D	53-62	alpha 2-HS glycoprotein	Homo sapiens	10-18
20872152-10	2010	High-dose cholecalciferol is safe and effective in correcting vitamin D insufficiency and results in a significant reduction in PTH levels in vitamin D-insufficient children.	Vitamin D	142-151	parathyroid hormone	Homo sapiens	128-131
20817794-2	2010	Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin resistance, and markers of inflammation in patients with PCOS, raising the possibility that some of the statin effects are mediated through vitamin D.	Vitamin D	26-35	insulin	Homo sapiens	110-117
20736967-10	2010	A negative correlation between PTH and both dietary vitamin D (r=-0.46; P&lt;0.01) and calcium intake (r =-0.41; P&lt;0.001) was observed.	Vitamin D	52-61	parathyroid hormone	Homo sapiens	31-34
20736967-11	2010	CONCLUSIONS: The low calcium and vitamin D intake observed in short-stature children and adolescents was associated with biochemical results, and suggested that PTH and calcium excretion may be useful screening tests for evaluating dietary calcium and vitamin D.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	161-164
20487587-0	2010	Vitamin D-vitamin K interaction: effect of vitamin D supplementation on serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, in Danish girls.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	107-118
21090935-2	2010	The antihypertensive effects of vitamin D include suppression of renin and parathyroid hormone levels and renoprotective, anti-inflammatory and vasculoprotective properties.	Vitamin D	32-41	renin	Homo sapiens	65-70
20813185-0	2010	A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation.	Vitamin D	48-57	cell division cycle 25A	Rattus norvegicus	38-44
20094706-1	2010	UNLABELLED: Hypoparathyroidism, a disorder characterized by low parathyroid hormone (PTH), is generally treated with oral calcium and vitamin D supplementation.	Vitamin D	134-143	parathyroid hormone	Homo sapiens	85-88
20487587-0	2010	Vitamin D-vitamin K interaction: effect of vitamin D supplementation on serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, in Danish girls.	Vitamin D	43-52	bone gamma-carboxyglutamate protein	Homo sapiens	107-118
20487587-2	2010	We have recently reported that serum percentage undercarboxylated osteocalcin (%ucOC; a marker of vitamin K status) was inversely correlated with serum 25-hydroxyvitamin D (25(OH)D) concentration (reflective of vitamin D status) in healthy Danish girls (aged 11-12 years), in line with a similar relationship reported in elderly women.	Vitamin D	162-171	bone gamma-carboxyglutamate protein	Homo sapiens	66-77
20651156-4	2010	This paper will review the circumstances leading to vitamin D deficiency in the African American population and will also discuss how vitamin D deficiency can affect the renin-angiotensin system, free radical production, inflammatory processes, and carbohydrate tolerance that in turn influence vascular endothelial function and vascular structure producing increased vascular resistance.	Vitamin D	134-143	renin	Homo sapiens	170-175
20858763-0	2010	Dietary vitamin D exposure prevents obesity-induced increase in endometrial cancer in Pten+/- mice.	Vitamin D	8-17	phosphatase and tensin homolog	Mus musculus	86-90
20605845-2	2010	Vitamin D is modified in the liver and the kidney to its active form (1,25-dihydroxyvitamin D) by the 25-hydroxy vitamin D 1-hydroxylase enzyme (CYP27B1).	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	145-152
20605845-5	2010	The action of vitamin D in these tissues is implicated in the regulation of endothelial, vascular smooth muscle, and cardiac cell function, the renin-angiotensin system, inflammatory and fibrotic pathways, and immune response.	Vitamin D	14-23	renin	Homo sapiens	144-149
20890434-4	2010	Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups.	Vitamin D	102-111	defensin beta 4A	Homo sapiens	6-21
20890434-4	2010	Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups.	Vitamin D	102-111	defensin beta 4A	Homo sapiens	23-27
20890434-4	2010	Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups.	Vitamin D	102-111	cathelicidin antimicrobial peptide	Homo sapiens	47-52
20890434-4	2010	Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups.	Vitamin D	147-156	defensin beta 4A	Homo sapiens	6-21
20890434-4	2010	Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups.	Vitamin D	147-156	cathelicidin antimicrobial peptide	Homo sapiens	47-52
20723601-6	2010	Vitamin D(3) metabolites increased ALP activity and induced mineralization when osteogenic supplements (OS; l-ascorbic acid-2-phosphate+beta-glycerophosphate) were added, though the expression of osteocalcin (OC) and osteopontin (OPN) were regulated without the addition of OS.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	196-207
20723601-7	2010	CYP24 and CYP27B1 expressions were upregulated by vitamin D(3) metabolites and 25OHD(3) was converted into 1alpha,25(OH)(2)D(3) in the culture medium.	Vitamin D	50-59	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	10-17
20610636-3	2010	Laboratory studies provided a mechanism for this link on the basis of findings that vitamin D metabolites regulate the expression of cathelicidin (LL-37), which is an endogenous antimicrobial peptide with activity against Mycobacterium tuberculosis.	Vitamin D	84-93	cathelicidin antimicrobial peptide	Homo sapiens	147-152
20601288-1	2010	INTRODUCTION: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered.	Vitamin D	44-53	parathyroid hormone	Homo sapiens	125-144
20518841-5	2010	CYP27B1 encodes 1-alpha hydroxylase, responsible for conversion of the vitamin D(3) precursor into its active form, involved in the immune function.	Vitamin D	71-80	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
20515678-1	2010	BACKGROUND: Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney.	Vitamin D	65-74	renin	Homo sapiens	136-141
20800785-11	2010	Vitamin D also increases synthesis of interleukin 10 by CD4+CD25+Foxp3+ T-regulatory cells and dendritic cells, while concurrently inhibiting dendritic cell activation by downregulating expression of costimulatory molecules CD40 and CD80/86.	Vitamin D	0-9	CD4 molecule	Homo sapiens	56-59
20631996-1	2010	While the effects of calcium, phosphorus intake, and vitamin D on parathyroid hormone (PTH) have been well studied, less is known about other factors that impact PTH.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	66-85
20805274-1	2010	OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.	Vitamin D	73-82	insulin	Homo sapiens	231-238
20554701-3	2010	We have tested the ability of purified mouse 25-hydroxyvitamin D(3) 1alpha-hydroxylase (CYP27B1) to add a 1alpha-hydroxyl group to this vitamin D analog and determined whether this altered its biological activity.	Vitamin D	55-64	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	88-95
20543868-2	2010	In this study, we show that SPRY2 expression in colon cancer cells is inhibited by the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) through E-cadherin-dependent and -independent mechanisms.	Vitamin D	94-103	sprouty RTK signaling antagonist 2	Homo sapiens	28-33
20711952-10	2010	Vitamin D also enhances inhibitory effect of insulin on IGFBP-1 production.	Vitamin D	0-9	insulin	Homo sapiens	45-52
20308769-0	2010	Impact of two regimens of vitamin D supplementation on calcium - vitamin D - PTH axis of schoolgirls of Delhi.	Vitamin D	26-35	parathyroid hormone	Homo sapiens	77-80
20308769-0	2010	Impact of two regimens of vitamin D supplementation on calcium - vitamin D - PTH axis of schoolgirls of Delhi.	Vitamin D	65-74	parathyroid hormone	Homo sapiens	77-80
20595682-2	2010	CKD associates with a decrease in liver cytochrome P450 (CYP450) enzymes, and specific CYP450 isoforms mediate vitamin D(3) C-25-hydroxylation, which forms calcidiol.	Vitamin D	111-120	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	87-93
20534770-0	2010	A novel G102E mutation of CYP27B1 in a large family with vitamin D-dependent rickets type 1.	Vitamin D	57-66	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	26-33
20534770-1	2010	CONTEXT: Mutations in the CYP27B1 gene, which encodes vitamin D 1alpha-hydroxylase, are the genetic basis for vitamin D-dependent rickets type 1 (VDDR-I).	Vitamin D	54-63	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	26-33
20534770-1	2010	CONTEXT: Mutations in the CYP27B1 gene, which encodes vitamin D 1alpha-hydroxylase, are the genetic basis for vitamin D-dependent rickets type 1 (VDDR-I).	Vitamin D	54-63	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	146-150
20228174-8	2010	Adjusted for time on PD and baseline serum albumin, oral active vitamin D therapy was associated with an 80% reduced relative risk of peritonitis [hazard ratio (HR): 0.20; 95% confidence interval (CI): 0.06 to 0.64; p = 0.007)].	Vitamin D	64-73	albumin	Homo sapiens	37-50
20543868-2	2010	In this study, we show that SPRY2 expression in colon cancer cells is inhibited by the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) through E-cadherin-dependent and -independent mechanisms.	Vitamin D	94-103	cadherin 1	Homo sapiens	173-183
20488884-1	2010	A central paradox of vitamin D biology is that 1alpha,25-(OH)(2) D(3) exposure inversely relates to colorectal cancer (CRC) risk despite a capacity for activation of both pro- and anti-oncogenic mediators including osteopontin (OPN)/CD44 and E-cadherin, respectively.	Vitamin D	21-30	cadherin 1	Homo sapiens	242-252
20672993-0	2010	Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	54-73
20672993-2	2010	We aimed to examine the impact of vitamin D status and tenofovir (TDF) use on PTH levels among HIV-infected patients receiving combination antiretroviral therapy (cART).	Vitamin D	34-43	parathyroid hormone	Homo sapiens	78-81
20672993-6	2010	Among subjects with suboptimal vitamin D status, PTH values greater than or equal to the ULN (87 pg/ml) were more common among TDF users than nonusers: 41% versus 0% (p = 0.018); and median PTH was higher in TDF users: 80 pg/ml versus 55 pg/ml (p = 0.02).	Vitamin D	31-40	parathyroid hormone	Homo sapiens	49-52
20616348-9	2010	The same vitamin D analogs suppressed plasma renin activity in patients receiving chronic hemodialysis.	Vitamin D	9-18	renin	Homo sapiens	45-50
20451678-10	2010	PTH response and phosphate status (above or below median level) correctly discriminated HF type in 73.8% of patients with vitamin D deficiency.	Vitamin D	122-131	parathyroid hormone	Homo sapiens	0-3
19565355-3	2010	Eventually, only those MSCs cultured in osteogenic media enriched with vitamin D(2) and FGF9, were positive for osteocalcin by RT-PCR.	Vitamin D	71-80	bone gamma-carboxyglutamate protein	Homo sapiens	112-123
20488884-8	2010	Taken together, these data indicate that the Apc(Min/+) genotype modulates vitamin D secosteroid actions to promote functional predominance of E-cadherin tumour suppressor activity within antagonistic molecular networks.	Vitamin D	75-84	cadherin 1	Homo sapiens	143-153
20722932-3	2010	However, whether vitamin D has immunoregulatory function on TNF-alpha and chemokines expression in human monocytes is still unknown.	Vitamin D	17-26	tumor necrosis factor	Homo sapiens	60-69
20148911-1	2010	OBJECTIVE: To investigate the influence of vitamin D status on parathyroid hormone and bone mass after a 2-year supplementation of calcium alone.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	63-82
19998245-3	2010	CYP27B1 encodes 1alpha-hydroxylase, responsible for conversion of the vitamin D (3) precursor into its active form, involved in the immune function.	Vitamin D	70-79	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
20672448-9	2010	Tenofovir use was not associated with serum creatinine or eGFR overall but interacted with vitamin D status (P = 0.05 and P = 0.08, respectively), being linked to somewhat higher creatinine and lower eGFR among patients without VDD but higher eGFR in VDD patients.	Vitamin D	91-100	epidermal growth factor receptor	Homo sapiens	200-204
20672448-9	2010	Tenofovir use was not associated with serum creatinine or eGFR overall but interacted with vitamin D status (P = 0.05 and P = 0.08, respectively), being linked to somewhat higher creatinine and lower eGFR among patients without VDD but higher eGFR in VDD patients.	Vitamin D	91-100	epidermal growth factor receptor	Homo sapiens	200-204
20486209-3	2010	This review summarizes studies of vitamin D and various endpoints considered in these cohorts, including risk of cardiovascular disease, hypertension, elevated plasma C-peptide, various cancers, bone fractures, and multiple sclerosis.	Vitamin D	34-43	insulin	Homo sapiens	167-176
25949458-0	2010	Pleiotropic effects of vitamin D in an early stage of chronic kidney disease-effect on insulin resistance.	Vitamin D	23-32	insulin	Homo sapiens	87-94
20649764-8	2010	Early intervention with intravenous or pulse oral vitamin D therapy at serum iPTH &lt;300 pg/mL can control serum phosphorus, calcium-phosphorus product, and PTH levels to the target ranges and slow the progression of secondary hyperparathyroidism.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	78-81
20435648-3	2010	Monocytes exposed to vitamin D(3) for 48 h were then stimulated with a TLR9 agonist for a further 24 h. The level of IL-6 secretion was measured by ELISA.	Vitamin D	21-30	interleukin 6	Homo sapiens	117-121
20435648-4	2010	RESULTS: CD14 was up-regulated, whereas TLR2, TLR4 and TLR9 expression was down-regulated by vitamin D(3) exposure in a time-dependent manner.	Vitamin D	93-102	toll like receptor 2	Homo sapiens	40-44
20435648-6	2010	TLR9-induced IL-6 production was impaired in monocytes treated with vitamin D(3) compared with untreated cells.	Vitamin D	68-77	interleukin 6	Homo sapiens	13-17
20427486-11	2010	Vitamin D-dependent antimicrobial responses are therefore likely to be strongly influenced by DBP polymorphisms.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	94-97
20385167-2	2010	One of the signaling pathways reported to be targeted by vitamin D is the NF-kappaB pathway, which is highly active in most immune cell types, including T cells.	Vitamin D	57-66	nuclear factor kappa B subunit 1	Homo sapiens	74-83
20385167-3	2010	However, the effects of vitamin D on the NF-kappaB pathway in T cells are not fully understood.	Vitamin D	24-33	nuclear factor kappa B subunit 1	Homo sapiens	41-50
20585188-4	2010	Some clinical studies clarified the improvement of reduction in PTH levels and achievement targets for serum calcium and phosphate levels by the combined therapy with cinacalcet and vitamin D sterols, such as OPTIMA or ACHIEVE study.	Vitamin D	182-191	parathyroid hormone	Homo sapiens	64-67
20052600-8	2010	These data suggest that vitamin D fulfillment is prerequisite for the TGF-beta1 genotype in exerting its full effect on the fracture prevalence.	Vitamin D	24-33	transforming growth factor beta 1	Homo sapiens	70-79
20661477-6	2010	Pharmacological inhibition of IL-1beta release from macrophages by vitamin D(3), a potent chemopreventive agent for colorectal cancer, restored the ability of TRAIL to induce apoptosis of tumor cells cultured with macrophages.	Vitamin D	67-76	interleukin 1 beta	Homo sapiens	30-38
20661477-6	2010	Pharmacological inhibition of IL-1beta release from macrophages by vitamin D(3), a potent chemopreventive agent for colorectal cancer, restored the ability of TRAIL to induce apoptosis of tumor cells cultured with macrophages.	Vitamin D	67-76	TNF superfamily member 10	Homo sapiens	159-164
20661477-10	2010	Vitamin D(3) halts this amplifying loop by interfering with the release of IL-1beta from macrophages.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	75-83
20661477-11	2010	Accordingly, vitamin D(3) sensitizes tumor cells to TRAIL-induced apoptosis, suggesting that the therapeutic efficacy of TRAIL could be augmented by this readily available chemopreventive agent.	Vitamin D	13-22	TNF superfamily member 10	Homo sapiens	52-57
20661477-11	2010	Accordingly, vitamin D(3) sensitizes tumor cells to TRAIL-induced apoptosis, suggesting that the therapeutic efficacy of TRAIL could be augmented by this readily available chemopreventive agent.	Vitamin D	13-22	TNF superfamily member 10	Homo sapiens	121-126
20484452-0	2010	Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	56-75
20484452-2	2010	OBJECTIVES: We aimed to assess vitamin D status on the basis of 25(OH)D and its relation with parathyroid hormone (PTH) and to identify possible predictors of 25(OH)D status in young children living in a country with minimal vitamin D fortification.	Vitamin D	31-40	parathyroid hormone	Homo sapiens	94-113
20587719-0	2010	Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes: comment to Kayaniyil et al.	Vitamin D	15-24	insulin	Homo sapiens	30-37
20214677-7	2010	Patients in the vitamin D-deficient group had higher serum PTH levels than those in the vitamin D-sufficient group : 71 +/- 24 pg/mL vs. 52 +/- 18 pg/mL (P = 0.04).	Vitamin D	16-25	parathyroid hormone	Homo sapiens	59-62
20427486-2	2010	Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear.	Vitamin D	5-14	D-box binding PAR bZIP transcription factor	Homo sapiens	73-76
20444911-10	2010	Women with low vitamin D (Vit-D) had also significantly higher risk of developing depressive mood over the follow-up (hazard ratio = 2.0; 95% confidence interval = 1.2-3.2; P = 0.005).	Vitamin D	15-24	vitrin	Homo sapiens	26-29
20138990-9	2010	In addition, they may contribute to the improvement of protocols for the clinical use of vitamin D compounds, as they indicate that advanced colon cancer patients overexpressing SNAIL1 and SNAIL2 are not suitable candidates for this therapy.	Vitamin D	89-98	snail family transcriptional repressor 1	Homo sapiens	178-184
20214988-2	2010	Calbindin-D9k and calbindin-D28k are vitamin D-dependent.	Vitamin D	37-46	S100 calcium binding protein G	Homo sapiens	0-13
20214991-1	2010	Parathyroid hormone (PTH) is used as a marker of vitamin D (VD) status.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	0-19
20227497-3	2010	Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	178-185
20227497-3	2010	Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits.	Vitamin D	78-87	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	178-185
20302931-0	2010	Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	27-61
20214991-1	2010	Parathyroid hormone (PTH) is used as a marker of vitamin D (VD) status.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	21-24
20304052-5	2010	In the present study, we have determined the inhibitory effect of a potent Gemini vitamin D analog BXL0124 (1alpha,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluoro-cholecalciferol) on the ErbB2/Her-2/neu overexpressing mammary tumorigenesis.	Vitamin D	82-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	238-243
20302931-8	2010	This review covers what we have learned in the past few years about the expression and function of CAMP under physiological and pathophysiological conditions, and addresses the potential future applications of vitamin D analogues to therapeutic regulation of CAMP expression.	Vitamin D	210-219	cathelicidin antimicrobial peptide	Homo sapiens	259-263
20398761-4	2010	On the other hand, it is possible that, in some patients, a persistent vitamin D deficiency induces, in the long-term, an autonomous secretion of PTH (i.e. tertiary hyperparathyroidism).	Vitamin D	71-80	parathyroid hormone	Homo sapiens	146-149
20304051-2	2010	The objective was to measure the effect of vitamin D supplementation, in vitamin D deficient women (25(OH)D concentration&lt;50 nmol/L), on osteocalcin (OC) and C-telopeptide (CTX).	Vitamin D	43-52	bone gamma-carboxyglutamate protein	Homo sapiens	140-151
20304052-0	2010	Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.	Vitamin D	7-16	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-40
20304052-0	2010	Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.	Vitamin D	7-16	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-94
20304052-0	2010	Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.	Vitamin D	7-16	AKT serine/threonine kinase 1	Homo sapiens	95-98
20304052-0	2010	Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.	Vitamin D	7-16	mitogen-activated protein kinase 1	Homo sapiens	99-102
20304052-4	2010	We have previously shown that Gemini vitamin D analogs significantly inhibited carcinogen-induced estrogen receptor (ER)-positive mammary tumorigenesis and reduced ER-negative MCF10DCIS.com xenograft tumor growth without hypercalcemic toxicity.	Vitamin D	37-46	estrogen receptor 1	Homo sapiens	98-115
20304052-4	2010	We have previously shown that Gemini vitamin D analogs significantly inhibited carcinogen-induced estrogen receptor (ER)-positive mammary tumorigenesis and reduced ER-negative MCF10DCIS.com xenograft tumor growth without hypercalcemic toxicity.	Vitamin D	37-46	estrogen receptor 1	Homo sapiens	117-119
20304052-4	2010	We have previously shown that Gemini vitamin D analogs significantly inhibited carcinogen-induced estrogen receptor (ER)-positive mammary tumorigenesis and reduced ER-negative MCF10DCIS.com xenograft tumor growth without hypercalcemic toxicity.	Vitamin D	37-46	estrogen receptor 1	Homo sapiens	164-166
20304052-5	2010	In the present study, we have determined the inhibitory effect of a potent Gemini vitamin D analog BXL0124 (1alpha,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluoro-cholecalciferol) on the ErbB2/Her-2/neu overexpressing mammary tumorigenesis.	Vitamin D	82-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	232-237
20304052-5	2010	In the present study, we have determined the inhibitory effect of a potent Gemini vitamin D analog BXL0124 (1alpha,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluoro-cholecalciferol) on the ErbB2/Her-2/neu overexpressing mammary tumorigenesis.	Vitamin D	82-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	244-247
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	26-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	74-79
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	26-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-138
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	26-35	AKT serine/threonine kinase 1	Homo sapiens	139-142
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	26-35	mitogen-activated protein kinase 1	Homo sapiens	143-146
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	190-199	erb-b2 receptor tyrosine kinase 2	Homo sapiens	74-79
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	190-199	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-138
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	190-199	AKT serine/threonine kinase 1	Homo sapiens	139-142
20304052-8	2010	In conclusion, the Gemini vitamin D analog BXL0124 inhibits the growth of ErbB2 overexpressing mammary tumors through regulating the ErbB2/AKT/ERK signaling pathways, suggesting that Gemini vitamin D analog may be considered for translational studies.	Vitamin D	190-199	mitogen-activated protein kinase 1	Homo sapiens	143-146
20398761-6	2010	Finally, as many, otherwise normal, subjects with vitamin D insufficiency may have an increased serum PTH level we believe that those with vitamin D insufficiency should be excluded from a reference population for serum PTH levels.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	102-105
20398761-6	2010	Finally, as many, otherwise normal, subjects with vitamin D insufficiency may have an increased serum PTH level we believe that those with vitamin D insufficiency should be excluded from a reference population for serum PTH levels.	Vitamin D	139-148	parathyroid hormone	Homo sapiens	102-105
20067903-13	2010	This transcription factor may downregulate the transcription of vitamin D-dependent genes and the CaSR expression.	Vitamin D	64-73	calcium sensing receptor	Homo sapiens	98-102
20505658-5	2010	Beyond the effect on parathyroid hormone suppression, the pleiotropic effect of vitamin D has been associated with improvement of cardiovascular risk factors, including increased renin activity, hypertension, inflammation, insulin resistance, diabetes, and albuminuria.	Vitamin D	80-89	renin	Homo sapiens	179-184
20505658-5	2010	Beyond the effect on parathyroid hormone suppression, the pleiotropic effect of vitamin D has been associated with improvement of cardiovascular risk factors, including increased renin activity, hypertension, inflammation, insulin resistance, diabetes, and albuminuria.	Vitamin D	80-89	insulin	Homo sapiens	223-230
19471320-5	2010	Low-calcemic vitamin D analogs have exhibited impressive therapeutic effects in various kidney disease models, with targets ranging from the NF-kappaB pathway to the renin-angiotensin system.	Vitamin D	13-22	renin	Homo sapiens	166-171
20102676-2	2010	The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	175-194
20429698-14	2010	Higher levels of PTH in winter and the elderly may reflect an impaired vitamin D status that may affect calcium homeostasis and bone health.	Vitamin D	71-80	parathyroid hormone	Homo sapiens	17-20
20530326-5	2010	This includes a newly identified gene-environment interaction between vitamin D and the main MS-linked HLA-DRB1*1501 allele and evidence showing that vitamin D levels are significantly lower in patients with MS as compared to controls.	Vitamin D	70-79	major histocompatibility complex, class II, DR beta 1	Homo sapiens	103-111
20102676-2	2010	The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	196-199
20511061-4	2010	In T2D, vitamin D supplementation can increase insulin sensitivity and decrease inflammation.	Vitamin D	8-17	insulin	Homo sapiens	47-54
20215450-0	2010	Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes.	Vitamin D	15-24	insulin	Homo sapiens	30-37
20215450-1	2010	OBJECTIVE: To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes.	Vitamin D	60-69	insulin	Homo sapiens	120-127
20215450-6	2010	CONCLUSIONS: Vitamin D may play a role in the pathogenesis of type 2 diabetes, as 25(OH)D concentration was independently associated with both insulin sensitivity and beta-cell function among individuals at risk of type 2 diabetes.	Vitamin D	13-22	insulin	Homo sapiens	143-150
20190231-7	2010	A significant relationship was observed between serum vitamin D levels and IIa fibre area (rho = 0.56, P = 0.002), and also, as a trend, between vitamin D and type IIb fibre area (rho = 0.39, p = 0.053); between vitamin D and muscle GPX (rho = 0.40, P = 0.025) and SOD activities (rho = 0.43, P = 0.012).	Vitamin D	54-63	ATPase, class II, type 9A	Mus musculus	75-78
20428782-1	2010	We have previously reported that by inducing calcium sensing receptor (CaSR), calcitriol, the active form of vitamin D, promoted the sensitivity of the human colon carcinoma cells to anticancer drugs.	Vitamin D	109-118	calcium sensing receptor	Homo sapiens	45-69
20428782-1	2010	We have previously reported that by inducing calcium sensing receptor (CaSR), calcitriol, the active form of vitamin D, promoted the sensitivity of the human colon carcinoma cells to anticancer drugs.	Vitamin D	109-118	calcium sensing receptor	Homo sapiens	71-75
20054540-12	2010	CONCLUSIONS: Vitamin D(3) deficiency was associated with a higher preoperative PTH level and a greater risk of LOH after MIP.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	79-82
20520739-11	2010	CONCLUSIONS: Current vitamin D status was associated with tPA concentrations, and to a lesser degree with fibrinogen and D-dimer, suggesting that vitamin D status/intake may be important for maintaining antithrombotic homeostasis.	Vitamin D	21-30	fibrinogen beta chain	Homo sapiens	106-116
20190231-7	2010	A significant relationship was observed between serum vitamin D levels and IIa fibre area (rho = 0.56, P = 0.002), and also, as a trend, between vitamin D and type IIb fibre area (rho = 0.39, p = 0.053); between vitamin D and muscle GPX (rho = 0.40, P = 0.025) and SOD activities (rho = 0.43, P = 0.012).	Vitamin D	145-154	ATPase, class II, type 9B	Mus musculus	164-167
20190231-7	2010	A significant relationship was observed between serum vitamin D levels and IIa fibre area (rho = 0.56, P = 0.002), and also, as a trend, between vitamin D and type IIb fibre area (rho = 0.39, p = 0.053); between vitamin D and muscle GPX (rho = 0.40, P = 0.025) and SOD activities (rho = 0.43, P = 0.012).	Vitamin D	145-154	ATPase, class II, type 9B	Mus musculus	164-167
20190231-11	2010	Multiple regression analysis disclosed that the only parameter independently related with type IIa fibre area was serum vitamin D.	Vitamin D	120-129	ATPase, class II, type 9A	Mus musculus	95-98
19645825-8	2010	Notably, the mechanism to upregulate hCAP18 following vitamin D treatment was functional in lesional as well as in non-lesional AD indicating that the CAMP gene is normally regulated in this respect.	Vitamin D	54-63	cathelicidin antimicrobial peptide	Homo sapiens	37-43
20150028-9	2010	A few clinical trials suggest beneficial effect of vitamin D supplementation in prediabetes, including improved insulin secretion, basal fasting insulin sensitivity, and postprandial peripheral insulin resistance.	Vitamin D	51-60	insulin	Homo sapiens	112-119
20150028-9	2010	A few clinical trials suggest beneficial effect of vitamin D supplementation in prediabetes, including improved insulin secretion, basal fasting insulin sensitivity, and postprandial peripheral insulin resistance.	Vitamin D	51-60	insulin	Homo sapiens	145-152
19645825-8	2010	Notably, the mechanism to upregulate hCAP18 following vitamin D treatment was functional in lesional as well as in non-lesional AD indicating that the CAMP gene is normally regulated in this respect.	Vitamin D	54-63	cathelicidin antimicrobial peptide	Homo sapiens	151-155
19645825-9	2010	In addition, cultured primary keratinocytes from non-lesional skin of psoriasis, AD and healthy skin, upregulated hCAP18mRNA following treatment with vitamin D.	Vitamin D	150-159	cathelicidin antimicrobial peptide	Homo sapiens	114-120
20362753-0	2010	Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations?	Vitamin D	5-14	C-reactive protein	Homo sapiens	56-74
20351344-1	2010	Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited.	Vitamin D	0-9	renin	Homo sapiens	24-29
20351344-4	2010	Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m(2) in renal plasma flow versus 145 mL/min per 1.73 m(2) among those with sufficient vitamin D levels; P for trend=0.009).	Vitamin D	21-30	angiotensinogen	Homo sapiens	107-113
20351344-4	2010	Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m(2) in renal plasma flow versus 145 mL/min per 1.73 m(2) among those with sufficient vitamin D levels; P for trend=0.009).	Vitamin D	238-247	angiotensinogen	Homo sapiens	107-113
20351344-5	2010	Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant.	Vitamin D	88-97	renin	Homo sapiens	16-21
21186539-2	2010	vitamin D as a hormone regulates calcium and phosphates homeostasis, and maintains regulates calcium and phosphates homeostasis, and maintains density and strength of bones, it also regulates the following: regulates composition and function of muscles (heart and skeletal) and of skin, metabolism (fat tissue and blood lipids, insulin and blood sugar), immune functions (in infection and autoimmune diseases), and it prevents cancer diseases and regulates cognitiove functions and mood-disorders (depression, dementia).	Vitamin D	0-9	insulin	Homo sapiens	328-335
20398267-0	2010	Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women.	Vitamin D	0-9	insulin	Homo sapiens	36-43
20398267-2	2010	Although the reason for this disparity is not known, it is possible that relatively low levels of vitamin D among AA may contribute, as vitamin D has been positively associated with insulin sensitivity in some studies.	Vitamin D	98-107	insulin	Homo sapiens	182-189
20398267-2	2010	Although the reason for this disparity is not known, it is possible that relatively low levels of vitamin D among AA may contribute, as vitamin D has been positively associated with insulin sensitivity in some studies.	Vitamin D	136-145	insulin	Homo sapiens	182-189
20398267-3	2010	The objective of this study was to test the hypothesis that dietary vitamin D would be associated with a robust measure of insulin sensitivity in AA and EA women.	Vitamin D	68-77	insulin	Homo sapiens	123-130
19934619-10	2010	The role of vitamin D deficiency, the most common cause of elevated PTH in the elderly, needs to be further investigated.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	68-71
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Vitamin D	249-258	nuclear factor kappa B subunit 1	Homo sapiens	15-36
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Vitamin D	249-258	nuclear factor kappa B subunit 1	Homo sapiens	38-47
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Vitamin D	249-258	nuclear factor kappa B subunit 1	Homo sapiens	162-171
20206692-6	2010	Together, we conclude that NF-kappaB signaling is critical for vitamin D sensitivity, and dysregulation of this pathway would result in vitamin D resistance and disease progression.	Vitamin D	63-72	nuclear factor kappa B subunit 1	Homo sapiens	27-36
20406950-3	2010	It is known that the interaction of the vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25D) with its functional vitamin D receptor leads to differentiation, G(1) arrest, and increased cell survival in p53-null AML cells.	Vitamin D	40-49	tumor protein p53	Homo sapiens	205-208
20406950-5	2010	Here, we examine vitamin D signaling in AML cells MOLM-13 and OCI-AML3 expressing wild-type p53 in the presence and absence of the MDM2 antagonist nutlin-3.	Vitamin D	17-26	RUNX family transcription factor 2	Homo sapiens	66-70
20406950-6	2010	We find that 1,25D alone induces monocytic differentiation in these cell lines similar to that seen in p53-null AML cells, suggesting that the presence of wild-type p53 is compatible with activation of vitamin D signaling.	Vitamin D	202-211	tumor protein p53	Homo sapiens	165-168
20371119-1	2010	1alpha,25-Dihydroxyvitamin D(3) (VD(3)), the biologically active form of vitamin D, may have either pro- or anti-inflammatory activities because of its diverse actions on nuclear factor kappa B (NF-kappaB).	Vitamin D	19-28	nuclear factor kappa B subunit 1	Homo sapiens	171-193
20371119-1	2010	1alpha,25-Dihydroxyvitamin D(3) (VD(3)), the biologically active form of vitamin D, may have either pro- or anti-inflammatory activities because of its diverse actions on nuclear factor kappa B (NF-kappaB).	Vitamin D	19-28	nuclear factor kappa B subunit 1	Homo sapiens	195-204
20398267-9	2010	CONCLUSIONS: This study provides novel findings that dietary vitamin D and calcium were independently associated with insulin sensitivity in AA, but not EA.	Vitamin D	61-70	insulin	Homo sapiens	118-125
20075384-8	2010	In ICS-untreated participants, dexamethasone-induced MKP-1 expression increased with higher vitamin D levels, with a 0.05 (+/-0.02)-fold increase (P = 0.02) in MKP-1 expression observed for each nanogram per milliliter increase in vitamin D, a finding that occurred in the absence of a significant increase in IL-10 expression.	Vitamin D	92-101	dual specificity phosphatase 1	Homo sapiens	53-58
20075384-8	2010	In ICS-untreated participants, dexamethasone-induced MKP-1 expression increased with higher vitamin D levels, with a 0.05 (+/-0.02)-fold increase (P = 0.02) in MKP-1 expression observed for each nanogram per milliliter increase in vitamin D, a finding that occurred in the absence of a significant increase in IL-10 expression.	Vitamin D	231-240	dual specificity phosphatase 1	Homo sapiens	160-165
20208539-4	2010	Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR).	Vitamin D	41-50	phospholipase C gamma 1	Homo sapiens	13-23
20162613-13	2010	Low vitamin D is linked to severe fibrosis and low SVR on interferon (IFN)-based therapy.	Vitamin D	4-13	interferon alpha 1	Homo sapiens	70-73
19820295-0	2010	The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome.	Vitamin D	14-23	insulin	Homo sapiens	47-54
19820295-2	2010	Aim of this study was aimed to determine the effect of vitamin D replacement therapy on glucose metabolism, insulin, and androgen levels in obese, insulin-resistant women with PCOS.	Vitamin D	55-64	insulin	Homo sapiens	108-115
19820295-2	2010	Aim of this study was aimed to determine the effect of vitamin D replacement therapy on glucose metabolism, insulin, and androgen levels in obese, insulin-resistant women with PCOS.	Vitamin D	55-64	insulin	Homo sapiens	147-154
20181886-6	2010	Interestingly, Clcn5 KO mice maintained on a high vitamin D diet attenuated DSS-induced colitis.	Vitamin D	50-59	chloride channel, voltage-sensitive 5	Mus musculus	15-20
20181886-9	2010	Our studies demonstrate that the loss of Clc-5 1) exhibits IL-6-mediated immunopathogenesis, 2) significantly exacerbated DSS-induced colitis, which is influenced by dietary factors, including vitamin D, and 3) portrays distinct NF-kappaB-modulated Th1-Th17 immune dysregulation, implying a role for CLC-5 in the immunopathogenesis of UC.	Vitamin D	193-202	chloride channel, voltage-sensitive 5	Mus musculus	41-46
19878298-0	2010	Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo.	Vitamin D	27-36	cathelicidin antimicrobial peptide	Homo sapiens	114-120
19878298-0	2010	Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo.	Vitamin D	27-36	cathelicidin antimicrobial peptide	Homo sapiens	121-126
19878298-7	2010	Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	103-109
19878298-7	2010	Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	167-173
19878298-7	2010	Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter.	Vitamin D	130-139	cathelicidin antimicrobial peptide	Homo sapiens	103-109
19878298-7	2010	Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter.	Vitamin D	130-139	cathelicidin antimicrobial peptide	Homo sapiens	167-173
19878298-10	2010	In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol.	Vitamin D	197-206	cathelicidin antimicrobial peptide	Homo sapiens	62-68
19878298-10	2010	In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol.	Vitamin D	197-206	cathelicidin antimicrobial peptide	Homo sapiens	69-74
19878298-10	2010	In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol.	Vitamin D	197-206	cathelicidin antimicrobial peptide	Homo sapiens	132-138
20227041-8	2010	Thus, p53 status can determine the biological impact of vitamin D on tumor cells.	Vitamin D	56-65	tumor protein p53	Homo sapiens	6-9
20175051-0	2010	Vitamin D treatment in hemodialysis patients with low serum levels of parathyroid hormone: which is the best choice?	Vitamin D	0-9	parathyroid hormone	Homo sapiens	70-89
20144976-1	2010	BACKGROUND: Vitamin D binding protein (DBP) acts as a vitamin D carrier and an actin scavenger.	Vitamin D	54-63	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
20144976-3	2010	In the present study, the relationship between serum DBP, lipoprotein fractions and vitamin D is investigated.	Vitamin D	84-93	D-box binding PAR bZIP transcription factor	Homo sapiens	53-56
20303002-3	2010	Here we report a 16-year-old girl with RLS secondary to vitamin D deficiency (VDD) caused by chronic administration of carbamazepine.	Vitamin D	56-65	RLS1	Homo sapiens	39-42
20020446-12	2010	By down-regulating MMP-9 levels active vitamin D derivatives may attenuate deleterious effects due to excessive TNFalpha-induced proteolytic activity associated with cutaneous inflammation.	Vitamin D	39-48	tumor necrosis factor	Homo sapiens	112-120
19774457-4	2010	Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism.	Vitamin D	132-141	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	95-102
19259778-13	2010	CONCLUSION: The in vitro inhibition of transforming growth factor alpha and interleukin 8 by paricalcitol confirms the immunomodulatory properties of this vitamin D analogue.	Vitamin D	155-164	tumor necrosis factor	Homo sapiens	39-71
19259778-13	2010	CONCLUSION: The in vitro inhibition of transforming growth factor alpha and interleukin 8 by paricalcitol confirms the immunomodulatory properties of this vitamin D analogue.	Vitamin D	155-164	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
20169063-3	2010	As vitamin D deficiency is reportedly common in SLE, we hypothesized that vitamin D might play a regulatory role in the IFNalpha amplification loop in SLE.	Vitamin D	3-12	interferon alpha 1	Homo sapiens	120-128
20089790-1	2010	The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status.	Vitamin D	44-53	parathyroid hormone	Homo sapiens	106-125
20308705-1	2010	There is increasing evidence for health benefits accomplished by activated vitamin D through interaction with the vitamin D receptor (VDR) that go beyond calcium and bone homeostasis and regulation of parathyroid hormone (PTH) secretion.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	201-220
20169063-3	2010	As vitamin D deficiency is reportedly common in SLE, we hypothesized that vitamin D might play a regulatory role in the IFNalpha amplification loop in SLE.	Vitamin D	74-83	interferon alpha 1	Homo sapiens	120-128
20169063-9	2010	Monocyte-derived DCs (MDDCs) of SLE patients were normally responsive to the regulatory effects of vitamin D in vitro as evidenced by decreased activation in response to LPS stimulation in the presence of 1,25-D. Additionally, vitamin D conditioning reduced expression of IFNalpha-regulated genes by healthy donor and SLE MDDCs in response to factors in activating SLE plasma.	Vitamin D	99-108	interferon alpha 1	Homo sapiens	272-280
20169063-9	2010	Monocyte-derived DCs (MDDCs) of SLE patients were normally responsive to the regulatory effects of vitamin D in vitro as evidenced by decreased activation in response to LPS stimulation in the presence of 1,25-D. Additionally, vitamin D conditioning reduced expression of IFNalpha-regulated genes by healthy donor and SLE MDDCs in response to factors in activating SLE plasma.	Vitamin D	227-236	interferon alpha 1	Homo sapiens	272-280
20169063-12	2010	We are encouraged to support the importance of adequate vitamin D supplementation and the need for a clinical trial to assess whether vitamin D supplementation affects IFNalpha activity in vivo and, most importantly, improves clinical outcome.	Vitamin D	134-143	interferon alpha 1	Homo sapiens	168-176
19931390-0	2010	Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	48-80
19781131-0	2010	Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial.	Vitamin D	0-9	insulin	Homo sapiens	34-41
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	76-83
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	nuclear receptor subfamily 3, group C, member 1	Mus musculus	270-275
20049649-5	2010	Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D(3).	Vitamin D	201-210	cathelicidin antimicrobial peptide	Homo sapiens	23-28
20049649-5	2010	Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D(3).	Vitamin D	201-210	cathelicidin antimicrobial peptide	Homo sapiens	175-181
19781131-0	2010	Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial.	Vitamin D	0-9	insulin	Homo sapiens	104-111
19781131-2	2010	Small, observational studies suggest an action for vitamin D in improving insulin sensitivity and/or insulin secretion.	Vitamin D	51-60	insulin	Homo sapiens	74-81
19781131-3	2010	The objective of the present study was to investigate the effect of improved vitamin D status on insulin resistance (IR), utilising randomised, controlled, double-blind intervention administering 100 microg (4000 IU) vitamin D(3) (n 42) or placebo (n 39) daily for 6 months to South Asian women, aged 23-68 years, living in Auckland, New Zealand.	Vitamin D	77-86	insulin	Homo sapiens	97-104
19781131-12	2010	In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion.	Vitamin D	25-34	insulin	Homo sapiens	45-52
20056760-2	2010	DESIGN, SETTING, PARTICIPANTS, &amp; MEASUREMENTS: We conducted a randomized, blinded, 3-month trial in vitamin D-deficient CKD stage 3 and 4 patients with parathyroid hormone (PTH) values above the Kidney Disease Outcomes Quality Initiative target, comparing cholecalciferol (4000 IU/d x 1 month, then 2000 IU/d; n = 22) to doxercalciferol (1 microg/d; n = 25).	Vitamin D	104-113	parathyroid hormone	Homo sapiens	156-175
19783860-2	2010	Vitamin D(3) is converted to 1,25(OH)D(3) by CYP2R1 and CYP27B1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	56-63
20156263-3	2010	Vitamin D acts through a nuclear receptor (VDR) and increases the expression of receptor activator of nuclear factor-kappaB ligand (rankl) and muscle segment homeobox 2 (msx2) genes.	Vitamin D	0-9	TNF superfamily member 11	Felis catus	80-130
20156263-3	2010	Vitamin D acts through a nuclear receptor (VDR) and increases the expression of receptor activator of nuclear factor-kappaB ligand (rankl) and muscle segment homeobox 2 (msx2) genes.	Vitamin D	0-9	TNF superfamily member 11	Felis catus	132-137
19621386-0	2010	Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU.	Vitamin D	0-9	calcium sensing receptor	Homo sapiens	66-90
19783860-4	2010	VDR, CYP27B1 or CYP2R1 gene variants could modify the biological activity of vitamin D(3).	Vitamin D	77-86	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	5-12
19837082-0	2010	Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene.	Vitamin D	75-84	arachidonate 5-lipoxygenase	Homo sapiens	129-143
19837082-2	2010	In an activity-guided approach using reporter gene assays where the distal part of the 5-LO gene was included in the reporter gene plasmid, we localized vitamin D response elements (VDREs) within exon 10, exon 12, and intron M. We found that these newly identified VDRE sites are bound by vitamin D receptor both in vitro by gel-shift analysis and in vivo by chromatin immunoprecipitation assays.	Vitamin D	153-162	arachidonate 5-lipoxygenase	Homo sapiens	87-91
19948723-7	2010	These studies provide strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition, as Crohn"s pathogenesis is associated with attenuated NOD2 or DEFB2/HBD2 function.	Vitamin D	53-62	defensin beta 4A	Homo sapiens	221-226
19948723-7	2010	These studies provide strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition, as Crohn"s pathogenesis is associated with attenuated NOD2 or DEFB2/HBD2 function.	Vitamin D	53-62	defensin beta 4A	Homo sapiens	227-231
20439185-0	2010	Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures.	Vitamin D	0-9	interleukin 6	Homo sapiens	58-71
20008294-0	2010	Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	61-70
20008294-5	2010	We found that vitamin D induces IkappaBalpha, an NF-kappaB inhibitor, in airway epithelium and decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and CXCL10.	Vitamin D	14-23	NFKB inhibitor alpha	Homo sapiens	32-44
20008294-5	2010	We found that vitamin D induces IkappaBalpha, an NF-kappaB inhibitor, in airway epithelium and decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and CXCL10.	Vitamin D	14-23	nuclear factor kappa B subunit 1	Homo sapiens	49-58
20008294-5	2010	We found that vitamin D induces IkappaBalpha, an NF-kappaB inhibitor, in airway epithelium and decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and CXCL10.	Vitamin D	14-23	nuclear factor kappa B subunit 1	Homo sapiens	122-131
20008294-8	2010	Inhibiting NF-kappaB with an adenovirus vector that expressed a nondegradable form of IkappaBalpha mimicked the effects of vitamin D.	Vitamin D	123-132	nuclear factor kappa B subunit 1	Homo sapiens	11-20
20008294-8	2010	Inhibiting NF-kappaB with an adenovirus vector that expressed a nondegradable form of IkappaBalpha mimicked the effects of vitamin D.	Vitamin D	123-132	NFKB inhibitor alpha	Homo sapiens	86-98
20439185-0	2010	Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
19906814-2	2010	We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner.	Vitamin D	55-64	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	94-103
19921089-1	2010	Vitamin D-dependent rickets type II (VDDR-type II) is a rare disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	37-41
21139376-1	2010	The biologically active form of vitamin D, 1alpha,25-dihydroxy vitamin D3 (VD), regulates the synthesis of the bone Ca-binding proteins osteocalcin and osteopontin.	Vitamin D	32-41	bone gamma-carboxyglutamate protein	Homo sapiens	136-147
19966181-2	2010	Extrarenal conversion of 25-hydroxyvitamin D (25OHD) to the biologically active form of vitamin D, 1 alpha,25-dihydroxyvitamin D [1,25(OH)(2)D] is catalyzed in several cell types by the 1 alpha-hydroxylase (CYP27B1), but little is known about the expression or regulation of CYP27B1 in human bones.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	207-214
19906814-6	2010	The mechanism of aromatase down-regulation by calcitriol in BCa cells is therefore 2-fold: a direct repression of aromatase transcription via promoter II through the vitamin D-response elements identified in this promoter and an indirect suppression by reducing the levels of PGs.	Vitamin D	166-175	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	17-26
19966181-2	2010	Extrarenal conversion of 25-hydroxyvitamin D (25OHD) to the biologically active form of vitamin D, 1 alpha,25-dihydroxyvitamin D [1,25(OH)(2)D] is catalyzed in several cell types by the 1 alpha-hydroxylase (CYP27B1), but little is known about the expression or regulation of CYP27B1 in human bones.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	275-282
19966181-9	2010	We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)(2)D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I.	Vitamin D	132-141	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	104-111
19966181-9	2010	We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)(2)D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I.	Vitamin D	132-141	insulin like growth factor 1	Homo sapiens	160-165
19966181-9	2010	We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)(2)D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I.	Vitamin D	132-141	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	203-210
19966181-9	2010	We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)(2)D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I.	Vitamin D	132-141	insulin like growth factor 1	Homo sapiens	293-298
20505259-11	2010	The present study indicated that patients with vitamin D deficiency occasionally showed biochemical findings suggestive of PHP and that such patients could exhibit not only PHP type II pattern of response to exogenous PTH but also of type I pattern.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	218-221
20505259-12	2010	Thus our clinical observation suggests the complexity of PTH resistance in vitamin D deficiency and underscores the importance of diet to prevent the disorder.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	57-60
20055894-7	2010	Vitamin D stimulated CYP24A, BGLAP and TNFSF11 expression in hOB and these effects were modified by nontoxic LCA concentrations.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	29-34
20508384-0	2010	The administration of an active vitamin D(3) analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type Ib patients.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	109-128
20508384-2	2010	However, the effect of active vitamin D(3) on PTH truncations remains controversial.	Vitamin D	30-39	parathyroid hormone	Homo sapiens	46-49
20508384-11	2010	Possibly, active vitamin D(3) attenuates the effect of elevated calcium on PTH N-terminal truncation in PHP Ib patients.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	75-78
20055894-8	2010	LCA significantly decreased vitamin D stimulation of CYP24A, BGLAP and TNFSF11 gene expression at 72%, 79% and 56% (respectively).	Vitamin D	28-37	bone gamma-carboxyglutamate protein	Homo sapiens	61-66
20055894-9	2010	LCA alone has an agonistic effect, as has vitamin D, thus partially increasing CYP24A and BGLAP expression, but with no changes on TNFRSF11B expression.	Vitamin D	42-51	bone gamma-carboxyglutamate protein	Homo sapiens	90-95
20055894-11	2010	CONCLUSIONS: Lithocholic acid decreases the stimulatory effect of vitamin D on CYP24A, BGLAP and TNFSF11 expression in hOB.	Vitamin D	66-75	bone gamma-carboxyglutamate protein	Homo sapiens	87-92
20011094-7	2010	Vitamin D receptor gene polymorphisms and vitamin D interactions with the insulin like growth factor system may further influence glucose homeostasis.	Vitamin D	42-51	insulin	Homo sapiens	74-81
19824090-1	2009	Originally characterized as a cell-cycle inhibitor induced by vitamin D(3), the tumor suppressor vitamin-D(3) upregulated protein 1 (VDUP1) has increasingly been shown to play major physiological roles in cell differentiation and glucose metabolism.	Vitamin D	62-71	thioredoxin interacting protein	Homo sapiens	97-131
20871847-10	2010	In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P &lt; .0001), IFN-gamma (-38.9%, P &lt; .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P &lt; .0001), and IL-10 (-70.4%, P &lt; .0001).	Vitamin D	14-23	interferon gamma	Homo sapiens	121-130
20871847-10	2010	In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P &lt; .0001), IFN-gamma (-38.9%, P &lt; .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P &lt; .0001), and IL-10 (-70.4%, P &lt; .0001).	Vitamin D	14-23	interleukin 4	Homo sapiens	155-159
20871847-10	2010	In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P &lt; .0001), IFN-gamma (-38.9%, P &lt; .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P &lt; .0001), and IL-10 (-70.4%, P &lt; .0001).	Vitamin D	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
21274319-1	2010	Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased serum calcium (Ca) and inorganic phosphate concentrations, secondary hyperparathyroidism and decreased serum 25-hydroxyvitamin D (25(OH)D) levels.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	30-34
21274319-1	2010	Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased serum calcium (Ca) and inorganic phosphate concentrations, secondary hyperparathyroidism and decreased serum 25-hydroxyvitamin D (25(OH)D) levels.	Vitamin D	0-9	alkaline phosphatase, placental	Homo sapiens	96-116
21274319-1	2010	Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased serum calcium (Ca) and inorganic phosphate concentrations, secondary hyperparathyroidism and decreased serum 25-hydroxyvitamin D (25(OH)D) levels.	Vitamin D	0-9	alkaline phosphatase, placental	Homo sapiens	118-121
20639672-1	2010	Recent observational studies of patients with stage 3-5 chronic kidney disease (CKD) not undergoing dialysis have shown that even slight increases in parathyroid hormone (PTH) levels are associated with an increased cardiovascular risk, regardless of the serum levels of calcium and phosphorus and vitamin D therapy.	Vitamin D	298-307	parathyroid hormone	Homo sapiens	150-169
23112990-11	2010	CONCLUSIONS: It is concluded that vitamin D is as potent as vitamin E in increasing the activities of erythrocyte SOD and catalase in atopic dermatitis patients.	Vitamin D	34-43	catalase	Homo sapiens	122-130
19692182-5	2010	It appears that vitamin D insufficiency during pregnancy is potentially associated with increased risk of preeclampsia, insulin resistance and gestational diabetes mellitus.	Vitamin D	16-25	insulin	Homo sapiens	120-127
19515534-0	2010	Moderate alcohol intake is associated with decreased risk of insulin resistance among individuals with vitamin D insufficiency.	Vitamin D	103-112	insulin	Homo sapiens	61-68
19515534-1	2010	OBJECTIVE: To determine whether moderate alcohol intake modifies the association between low vitamin D levels and insulin resistance (IR), we hypothesized that moderate alcohol intake would have a modifying effect on IR in people with low vitamin D levels.	Vitamin D	93-102	insulin	Homo sapiens	114-121
19415373-1	2010	UNLABELLED: Although it is known that neurofibromatosis 1 (NF1) patients suffer from vitamin D deficiency and display decreased bone mineral density (BMD), a systematic clinical and histomorphometrical analysis is absent.	Vitamin D	85-94	neurofibromin 1	Homo sapiens	38-57
19415373-1	2010	UNLABELLED: Although it is known that neurofibromatosis 1 (NF1) patients suffer from vitamin D deficiency and display decreased bone mineral density (BMD), a systematic clinical and histomorphometrical analysis is absent.	Vitamin D	85-94	neurofibromin 1	Homo sapiens	59-62
19415373-2	2010	Our data demonstrate that NF1 patients display high bone turnover and accumulation of osteoid and that supplementation of vitamin D has a beneficial effect on their BMD.	Vitamin D	122-131	neurofibromin 1	Homo sapiens	26-29
19415373-4	2010	Although it has been reported that NF1 patients have decreased vitamin D serum levels, the manifestation of the disease at the bone tissue level has rarely been analyzed.	Vitamin D	63-72	neurofibromin 1	Homo sapiens	35-38
21387797-3	2010	The most probable explanation of this phenomenon is that vitamin D precursor releases hormonal form of vitamin from its binding with serum transporting protein (DBP) stimulating in this way transcription of genes in cells of target tissues.	Vitamin D	57-66	D-box binding PAR bZIP transcription factor	Homo sapiens	161-164
20003316-3	2009	Worryingly, recent observational data has highlighted an association between hypovitaminosis D and increased cardiovascular mortality, possibly mediated via vitamin D effects on insulin resistance and inflammation.	Vitamin D	157-166	insulin	Homo sapiens	178-185
20003316-4	2009	The main hypothesis of this study is that oral Vitamin D supplementation will ameliorate insulin resistance in patients with Chronic Kidney Disease stage 3 when compared to placebo.	Vitamin D	47-56	insulin	Homo sapiens	89-96
19824090-1	2009	Originally characterized as a cell-cycle inhibitor induced by vitamin D(3), the tumor suppressor vitamin-D(3) upregulated protein 1 (VDUP1) has increasingly been shown to play major physiological roles in cell differentiation and glucose metabolism.	Vitamin D	62-71	thioredoxin interacting protein	Homo sapiens	133-138
19943126-8	2009	Oral intake of 1alpha hydroxy vitamin D(3) (1alpha(OH)D(3)) in rickets patients for 4 weeks significantly increased hCAP18 expression in neutrophils compared to age-matched healthy controls without 1alpha(OH)D(3), indicating the potential of vitamin D(3) as a regulator of the innate immune response of neonates.	Vitamin D	30-39	cathelicidin antimicrobial peptide	Homo sapiens	116-122
19666939-1	2009	BACKGROUND: Toddlers in Pune, India, accustomed to low dietary calcium intake but vitamin D replete have low serum ionised calcium and inappropriately raised serum inorganic phosphorus concentrations together with elevated serum parathyroid hormone (PTH) concentrations.	Vitamin D	82-91	parathyroid hormone	Homo sapiens	229-248
19956103-2	2009	Vitamin D deficiency is likely to be one of the many environmental factors influencing T1D development and diagnosis, and, hence, the hormone receptor gene, VDR, was examined for association with T1D risk.	Vitamin D	0-9	nuclear receptor subfamily 4 group A member 1	Homo sapiens	134-150
19683963-6	2009	In particular, "hormone-like" FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined.	Vitamin D	126-135	fibroblast growth factor 21	Homo sapiens	37-42
19861511-4	2009	In the calcium, vitamin D, and calcium plus vitamin D groups relative to the placebo, p21 expression increased by 201% (P = 0.03), 242% (P = 0.005), and 25% (P = 0.47), respectively, along the full lengths of colorectal crypts after 6 months of treatment.	Vitamin D	16-25	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-89
20369636-0	2009	Hype-D up about vitamin D.	Vitamin D	16-25	FIC domain protein adenylyltransferase	Homo sapiens	0-4
20948693-1	2009	Vitamin D may have a protective role in insulin secretion and an effect on insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	40-47
19545951-7	2009	Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58.	Vitamin D	0-9	protein disulfide isomerase family A member 3	Homo sapiens	256-261
19545951-7	2009	Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58.	Vitamin D	0-9	protein disulfide isomerase family A member 3	Homo sapiens	262-267
19861511-4	2009	In the calcium, vitamin D, and calcium plus vitamin D groups relative to the placebo, p21 expression increased by 201% (P = 0.03), 242% (P = 0.005), and 25% (P = 0.47), respectively, along the full lengths of colorectal crypts after 6 months of treatment.	Vitamin D	44-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-89
19591967-5	2009	BM cultures from MIF KO mice that were treated with M-CSF and RANKL, PTH or vitamin D had significantly increased OCL number compared to cells from WT mice.	Vitamin D	76-85	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	17-20
19814732-0	2009	Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1.	Vitamin D	0-9	checkpoint kinase 1	Homo sapiens	138-157
19852851-3	2009	METHODS: Eleven candidate genes were chosen for this study, five of which code for proteins in the vitamin D metabolism pathway (CYP27A1, CYP27B1, CYP2R1, CYP24A1, GC) and six that are known to be transcriptionally regulated by vitamin D (IL10, IL1RL1, CD28, CD86, IL8, SKIIP).	Vitamin D	99-108	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	138-145
19829383-4	2009	Reflecting vitamin-D-mediated transrepression of the CYP27B1 gene by the negative vitamin D response element (nVDRE), methylation of CpG sites ((5m)CpG) is induced by vitamin D in this gene promoter.	Vitamin D	11-20	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	53-60
19829383-4	2009	Reflecting vitamin-D-mediated transrepression of the CYP27B1 gene by the negative vitamin D response element (nVDRE), methylation of CpG sites ((5m)CpG) is induced by vitamin D in this gene promoter.	Vitamin D	82-91	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	53-60
19829383-4	2009	Reflecting vitamin-D-mediated transrepression of the CYP27B1 gene by the negative vitamin D response element (nVDRE), methylation of CpG sites ((5m)CpG) is induced by vitamin D in this gene promoter.	Vitamin D	167-176	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	53-60
19821349-1	2009	BACKGROUND: Clinical guidelines recommend vitamin D compounds to suppress serum parathyroid hormone (PTH) in chronic kidney disease (CKD), however treatment may be associated with increased serum phosphorus and calcium, which are associated with increased mortality in observational studies.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	80-99
19438810-5	2009	Through screening of components secreted from keratinocytes, the vitamin D(3) analogue was found to promote TGF-beta(2) expression and ALP activity of hDPCs.	Vitamin D	65-74	transforming growth factor, beta 1	Rattus norvegicus	108-116
19438810-5	2009	Through screening of components secreted from keratinocytes, the vitamin D(3) analogue was found to promote TGF-beta(2) expression and ALP activity of hDPCs.	Vitamin D	65-74	alkaline phosphatase, placental	Homo sapiens	135-138
19531669-9	2009	After the 12-month vitamin D(3) supplementation, there was a marked decrease in [Ca(2+)](i) [105 (103-112) nmol/l, P &lt; 0.001 versus baseline], independently of the increase in 25(OH)D(3) or the decrease in PTH levels.	Vitamin D	19-28	parathyroid hormone	Homo sapiens	209-212
19821446-1	2009	BACKGROUND: Vitamin D compounds are used to suppress elevated serum parathyroid hormone (PTH) in people with chronic kidney disease (CKD).	Vitamin D	12-21	parathyroid hormone	Homo sapiens	68-87
19821446-1	2009	BACKGROUND: Vitamin D compounds are used to suppress elevated serum parathyroid hormone (PTH) in people with chronic kidney disease (CKD).	Vitamin D	12-21	parathyroid hormone	Homo sapiens	89-92
19821446-11	2009	Vitamin D compounds significantly lowered serum PTH (4 studies, 153 patients: MD -49.34 pg/mL, 95% CI -85.70 to -12.97 (-5.6 pmol/L, 95% CI -9.77 to -1.48)) and were more likely to reduce serum PTH &gt; 30% from baseline value (264 patients: RR 7.87, 95% CI 4.87 to 12.73).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	48-51
19821446-11	2009	Vitamin D compounds significantly lowered serum PTH (4 studies, 153 patients: MD -49.34 pg/mL, 95% CI -85.70 to -12.97 (-5.6 pmol/L, 95% CI -9.77 to -1.48)) and were more likely to reduce serum PTH &gt; 30% from baseline value (264 patients: RR 7.87, 95% CI 4.87 to 12.73).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	194-197
19821446-15	2009	While vitamin D compounds reduce serum PTH (49.3 pg/mL (5.6 pmol/L)) compared with placebo, the relative clinical benefits of PTH lowering versus treatment-related increases in serum phosphorus and calcium remain to be understood.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	39-42
19519975-7	2009	The present open trial suggests that fortified soft plain cheese consumed by elderly women with vitamin D insufficiency can reduce bone resorption markers by positively influencing Ca and protein economy, as expressed by decreased PTH and increased IGF-I, respectively.	Vitamin D	96-105	insulin like growth factor 1	Homo sapiens	249-254
19591967-5	2009	BM cultures from MIF KO mice that were treated with M-CSF and RANKL, PTH or vitamin D had significantly increased OCL number compared to cells from WT mice.	Vitamin D	76-85	occludin	Mus musculus	114-117
19615945-7	2009	Vitamin D(3) significantly reduced the MMP-7 (p=0.0001) and MMP-9 (p=0.0001) and increased the TIMP-1 (p=0.005) level in antigen stimulated and unstimulated cultures of PTB as compared to HC.	Vitamin D	0-9	TIMP metallopeptidase inhibitor 1	Homo sapiens	95-101
19763373-0	2009	Elevated serum PTH is independently associated with poor outcomes in older patients with hip fracture and vitamin D inadequacy.	Vitamin D	106-115	parathyroid hormone	Homo sapiens	15-18
19672573-0	2009	Does vitamin D status contribute to caveolin-1-mediated insulin sensitivity in skeletal muscle?	Vitamin D	5-14	caveolin 1	Homo sapiens	36-46
19339050-0	2009	c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.	Vitamin D	131-140	mitogen-activated protein kinase 9	Homo sapiens	0-25
19597711-0	2009	The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance.	Vitamin D	24-33	adiponectin, C1Q and collagen domain containing	Homo sapiens	57-68
19597711-1	2009	Vitamin D status assessed by serum 25-hydroxyvitamin D levels (25(OH)D) has been shown to be inversely associated with insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	119-126
19597711-3	2009	In the present study, we assessed the prevalence of inadequate vitamin D levels and its relationship to glucose tolerance status and circulating adiponectin in healthy Thai population.	Vitamin D	63-72	adiponectin, C1Q and collagen domain containing	Homo sapiens	145-156
19597711-18	2009	We demonstrated an association between insufficient vitamin D status and lower circulating adiponectin in subjects with abnormal glucose tolerance independently of adiposity which may indicate the role of adiponectin as a link between vitamin D status and insulin resistance.	Vitamin D	52-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	91-102
19597711-18	2009	We demonstrated an association between insufficient vitamin D status and lower circulating adiponectin in subjects with abnormal glucose tolerance independently of adiposity which may indicate the role of adiponectin as a link between vitamin D status and insulin resistance.	Vitamin D	235-244	adiponectin, C1Q and collagen domain containing	Homo sapiens	91-102
19597711-18	2009	We demonstrated an association between insufficient vitamin D status and lower circulating adiponectin in subjects with abnormal glucose tolerance independently of adiposity which may indicate the role of adiponectin as a link between vitamin D status and insulin resistance.	Vitamin D	235-244	adiponectin, C1Q and collagen domain containing	Homo sapiens	205-216
19584181-3	2009	OBJECTIVE: This study explores the effects of vitamin D replacement on insulin sensitivity, endothelial function, inflammation, oxidative stress, and leptin in vitamin D-deficient subjects.	Vitamin D	46-55	insulin	Homo sapiens	71-78
19339050-0	2009	c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.	Vitamin D	131-140	mitogen-activated protein kinase 9	Homo sapiens	27-31
19748465-3	2009	We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5.	Vitamin D	27-36	autophagy related 5	Homo sapiens	207-211
19667162-3	2009	There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the hepatic microsomal or mitochondrial vitamin D-25-hydroxylase (CYP27A1) and the renal mitochondrial 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) for vitamin D and 25(OH)D3 (calcidiol), respectively.	Vitamin D	90-99	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	244-251
19667156-3	2009	First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 (calcitriol) on the expression of COX-2 and 15-PGDH.	Vitamin D	47-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	154-159
19667162-11	2009	Further study of the impact of CYP27B1 splice variants on the vitamin D pathway in keratinocytes and other cell types is warranted.	Vitamin D	62-71	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	31-38
19667157-4	2009	First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 on the expression of COX-2 and 15-PGDH.	Vitamin D	47-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	141-146
19667164-3	2009	Vitamin D metabolism poses unique problems for the regulation of 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations in the tissues outside the kidney that possess 25(OH)D-1-hydroxylase [CYP27B1] and the catabolic enzyme, 1,25(OH)2D-24-hydroxylase [CYP24].	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	187-194
19667166-7	2009	1,25(OH)2D3 and calcium interact in modulating cell growth in different ways: (i) Signaling pathways from the VDR and the CaR converge on the same downstream elements, e.g. of the canonical Wnt pathway; (ii) high extracellular calcium modulates extrarenal vitamin D metabolism in favor of higher local steady-state concentrations of 1,25(OH)2D3; (iii) 1,25(OH)2D3 may up-regulate expression of the CaR and thus augment CaR-mediated antiproliferative responses to high extracellular Ca2+.	Vitamin D	256-265	calcium sensing receptor	Homo sapiens	122-125
19478099-2	2009	In the kidney, vitamin D may be important for maintaining podocyte health, preventing epithelial-to-mesenchymal transformation, and suppressing renin gene expression and inflammation.	Vitamin D	15-24	renin	Homo sapiens	144-149
19370371-1	2009	BACKGROUND: Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes.	Vitamin D	40-49	insulin	Homo sapiens	76-83
19702932-2	2009	In bone cells, the vitamin D receptor (VDR) and the steroid and xenobiotic receptor (SXR) are activated by vitamin D and vitamin K2, respectively.	Vitamin D	19-28	nuclear receptor subfamily 1 group I member 2	Homo sapiens	85-88
19340862-1	2009	BACKGROUND: The aim of this study was to investigate vitamin D deficiency as an etiology for patients with elevated parathormone (PTH) levels after parathyroidectomy.	Vitamin D	53-62	parathyroid hormone	Homo sapiens	130-133
19549742-1	2009	CONTEXT: Vitamin D status can influence insulin resistance.	Vitamin D	9-18	insulin	Homo sapiens	40-47
19382910-9	2009	In a functional test of this novel pathway, we demonstrated that vitamin D(3) was able to rescue cells from TRAIL-induced apoptosis through regulation of the PEA-15 expression and function.	Vitamin D	65-74	TNF superfamily member 10	Homo sapiens	108-113
19549742-11	2009	CONCLUSIONS: Vitamin D deficiency is highly prevalent in obese, AA female adolescents and may promote insulin resistance.	Vitamin D	13-22	insulin	Homo sapiens	102-109
19549742-12	2009	Our data suggest that a 25(OH)D concentration of 15 ng/ml or less may be the threshold by which vitamin D deficiency confers negative effects on insulin sensitivity.	Vitamin D	96-105	insulin	Homo sapiens	145-152
19811264-13	2009	Since the inhibition of TNFalpha was more effective in patients, vitamin D supplementation might be an additional therapeutical approach.	Vitamin D	65-74	tumor necrosis factor	Homo sapiens	24-32
19151911-3	2009	With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was observed.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	64-67
19151911-12	2009	RESULTS: Vitamin D insufficiency (&lt;50 nmol/L) was observed in 85% of expeditioners by 6 months when serum calcium decreased and PTH increased (p &lt; 0.01).	Vitamin D	9-18	parathyroid hormone	Homo sapiens	131-134
19592334-9	2009	It has been demonstrated that vitamin D has a high impact on congestive heart failure main risk factors as hypertension, renin-angiotensin system malfunction and atherosclerosis.	Vitamin D	30-39	renin	Homo sapiens	121-126
19178594-3	2009	The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], has previously been reported to inhibit secretion of MMP-9 in human monocytes (MN), but its influence on the secretion and gene expression of MMP and tissue inhibitors of MMP (TIMP) in M. tuberculosis-infected cells has not previously been investigated.	Vitamin D	25-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	268-272
19488670-3	2009	As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to maintain calcium homeostasis through the vitamin D endocrine system.	Vitamin D	49-58	D-box binding PAR bZIP transcription factor	Homo sapiens	76-79
19488670-3	2009	As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to maintain calcium homeostasis through the vitamin D endocrine system.	Vitamin D	145-154	D-box binding PAR bZIP transcription factor	Homo sapiens	76-79
19883895-7	2009	PTH showed a positive correlation with weight (r = 0.362, p = 0.03), lean mass (r = 0.372, p = 0.039), and a negative association with plasma concentrations of calcium (r = -0.48, p = 0.003) and 25(OH) vitamin D (r = -0.44, p = 0.014).	Vitamin D	202-211	parathyroid hormone	Homo sapiens	0-3
19662683-0	2009	Cystatin D is a candidate tumor suppressor  gene induced by vitamin D in human  colon cancer cells.	Vitamin D	60-69	cystatin D	Homo sapiens	0-10
19414624-8	2009	Higher protein expression of CYP3A4, MRP2, P-gp, and MRP4 was also observed after a 6-day treatment with other vitamin D analogs (100 nM 1alpha-hydroxyvitamin D(3),1alpha-hydroxyvitamin D(2) or Hectorol, and 25-hydroxyvitamin D(3)) in Caco-2 cells, suggesting a role of 1,25(OH)(2)D(3) and analogs in the activation of enzymes and transporters via the vitamin D receptor.	Vitamin D	111-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
19415724-5	2009	Subjects with vitamin D deficiency [25(OH)D level less than 50 nmol/L (20 ng/mL)] had higher mean values of serum C-reactive protein (CRP) (2.40 mg/L vs. 0.84 mg/L, P = 0.02) and creatinine (1.75 mg/dL vs. 1.24 mg/dL, P = 0.03) and lower serum albumin values (3.12 g/dL vs. 3.39 g/dL, P = 0.003) compared to subjects without vitamin D deficiency.	Vitamin D	14-23	C-reactive protein	Homo sapiens	114-132
19623255-7	2009	All vitamin D analogs tested blocked IL-17A induced HBD2 expression by increasing IkappaB-alpha protein and inhibition of NF-kappaB signaling.	Vitamin D	4-13	defensin beta 4A	Homo sapiens	52-56
19623255-7	2009	All vitamin D analogs tested blocked IL-17A induced HBD2 expression by increasing IkappaB-alpha protein and inhibition of NF-kappaB signaling.	Vitamin D	4-13	NFKB inhibitor alpha	Homo sapiens	82-95
19623255-8	2009	At the same time vitamin D analogs induced cathelicidin through activation of the vitamin D receptor and MEK/ERK signaling.	Vitamin D	17-26	mitogen-activated protein kinase kinase 7	Homo sapiens	105-108
19623255-8	2009	At the same time vitamin D analogs induced cathelicidin through activation of the vitamin D receptor and MEK/ERK signaling.	Vitamin D	17-26	mitogen-activated protein kinase 1	Homo sapiens	109-112
19415724-5	2009	Subjects with vitamin D deficiency [25(OH)D level less than 50 nmol/L (20 ng/mL)] had higher mean values of serum C-reactive protein (CRP) (2.40 mg/L vs. 0.84 mg/L, P = 0.02) and creatinine (1.75 mg/dL vs. 1.24 mg/dL, P = 0.03) and lower serum albumin values (3.12 g/dL vs. 3.39 g/dL, P = 0.003) compared to subjects without vitamin D deficiency.	Vitamin D	14-23	C-reactive protein	Homo sapiens	134-137
19415724-8	2009	Association of vitamin D deficiency with higher serum CRP, serum creatinine and ISS stage at time of diagnosis suggests that vitamin D deficiency may portend poorer outcomes in subjects with MM.	Vitamin D	15-24	C-reactive protein	Homo sapiens	54-57
19768253-5	2009	In obese individuals, the impaired vitamin D endocrine system, characterized by high levels of PTH and 1,25(OH)(2)D(3) could induce a negative feedback for the hepatic synthesis of 25(OH)D and also contribute to a higher intracellular calcium, which in turn secrete less insulin and deteriorate insulin sensitivity.	Vitamin D	35-44	insulin	Homo sapiens	271-278
19768253-6	2009	In hypertension, vitamin D could act on renin-angiotensin system and also in vascular function.	Vitamin D	17-26	renin	Homo sapiens	40-45
19768259-4	2009	The calcium and vitamin D content in dairy foods could have beneficial effects on glucose metabolism and renin/angiotensin system as well regulates body weight.	Vitamin D	16-25	renin	Homo sapiens	105-110
19232403-6	2009	Of note, Na/Pi-IIc KO mice display abnormal vitamin D regulation without hypophosphatemia or hyperphosphaturia.	Vitamin D	44-53	solute carrier family 34 member 3	Homo sapiens	9-18
19607716-3	2009	An ancient primate-specific Alu short interspersed element (SINE) put the human CAMP gene under the regulation of the vitamin D pathway by providing a perfect vitamin D receptor binding element (VDRE) in its promoter.	Vitamin D	118-127	cathelicidin antimicrobial peptide	Homo sapiens	80-84
19607716-6	2009	Evidence for evolutionary conservation of this regulation in additional primate lineages would provide strong evidence that the TLR2/1-vitamin D-cathelicidin pathway evolved as a biologically important immune response mechanism protecting human and non-human primates against infection.	Vitamin D	135-144	toll like receptor 2	Homo sapiens	128-134
19607716-13	2009	Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D.	Vitamin D	78-87	cathelicidin antimicrobial peptide	Homo sapiens	44-48
19607716-13	2009	Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D.	Vitamin D	187-196	cathelicidin antimicrobial peptide	Homo sapiens	44-48
19232403-7	2009	Thus, Na/Pi-IIc may be involved in regulating renal vitamin D synthesis in the proximal tubular cells.	Vitamin D	52-61	solute carrier family 34 member 3	Homo sapiens	6-15
20592793-6	2009	Vitamin D upregulates production of human cathelicidin, LL-37, which has both antimicrobial and antiendotoxin activities.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	56-61
19302999-0	2009	Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.	Vitamin D	31-40	D-box binding PAR bZIP transcription factor	Homo sapiens	58-61
19403634-10	2009	Further research is needed to clarify which population subgroups show responses of PTH, BMD, and/or calcium absorption in response to changes in vitamin D status.	Vitamin D	145-154	parathyroid hormone	Homo sapiens	83-86
19301038-2	2009	However, the effect of chronic calcium changes and different vitamin D doses on these PTH measurements remains to be defined.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	86-89
19503839-2	2009	In humans, activation of Toll-like receptor 2/1 (TLR2/1) on monocytes induces a vitamin D dependent antimicrobial activity against intracellular mycobacteria.	Vitamin D	80-89	toll like receptor 2	Homo sapiens	25-47
19503839-2	2009	In humans, activation of Toll-like receptor 2/1 (TLR2/1) on monocytes induces a vitamin D dependent antimicrobial activity against intracellular mycobacteria.	Vitamin D	80-89	toll like receptor 2	Homo sapiens	49-55
19503839-6	2009	The differential requirements for induction of DEFB4 and cathelicidin were reflected by differences in their respective promoter regions; the DEFB4 promoter had one vitamin D response element (VDRE) and two NF-kappaB sites, whereas the cathelicidin promoter had three VDREs and no NF-kappaB sites.	Vitamin D	165-174	defensin beta 4A	Homo sapiens	47-52
19503839-6	2009	The differential requirements for induction of DEFB4 and cathelicidin were reflected by differences in their respective promoter regions; the DEFB4 promoter had one vitamin D response element (VDRE) and two NF-kappaB sites, whereas the cathelicidin promoter had three VDREs and no NF-kappaB sites.	Vitamin D	165-174	defensin beta 4A	Homo sapiens	142-147
19503839-9	2009	Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen.	Vitamin D	117-126	interleukin 1 beta	Homo sapiens	92-100
19403634-6	2009	Vitamin D supplementation (without calcium) significantly lowered circulating PTH (WMD: -0.29 pmol/L; 95% CI: -0.56, -0.02; 11 RCTs; I2 = 29%), but this was not apparent in the presence of calcium supplementation.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	78-81
19056306-0	2009	Vitamin D and growth hormone regulate growth hormone/insulin-like growth factor (GH-IGF) axis gene expression in human fetal epiphyseal chondrocytes.	Vitamin D	0-9	growth hormone 1	Homo sapiens	38-52
19473635-1	2009	BACKGROUND: Falecalcitriol is a novel vitamin D analog, which has a greater potential to suppress parathyroid hormone (PTH) and a longer half-life.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	98-117
19473635-1	2009	BACKGROUND: Falecalcitriol is a novel vitamin D analog, which has a greater potential to suppress parathyroid hormone (PTH) and a longer half-life.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	119-122
19289535-0	2009	Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population.	Vitamin D	0-9	insulin	Homo sapiens	49-56
19289535-0	2009	Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population.	Vitamin D	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	73-84
19473453-0	2009	Low parathyroid hormone levels in bedridden geriatric patients with vitamin D deficiency.	Vitamin D	68-77	parathyroid hormone	Homo sapiens	4-23
19473453-9	2009	PTH remained within reference values even after 6 months in 76.2% of the patients with persistent vitamin D deficiency in the placebo group.	Vitamin D	98-107	parathyroid hormone	Homo sapiens	0-3
19473453-1	2009	OBJECTIVES: To identify the clinical conditions associated with low parathyroid hormone (PTH) in patients with vitamin D deficiency and to evaluate the stability of the blunted PTH response to vitamin D deficiency over 6 months.	Vitamin D	111-120	parathyroid hormone	Homo sapiens	68-87
19473453-1	2009	OBJECTIVES: To identify the clinical conditions associated with low parathyroid hormone (PTH) in patients with vitamin D deficiency and to evaluate the stability of the blunted PTH response to vitamin D deficiency over 6 months.	Vitamin D	111-120	parathyroid hormone	Homo sapiens	89-92
19473453-1	2009	OBJECTIVES: To identify the clinical conditions associated with low parathyroid hormone (PTH) in patients with vitamin D deficiency and to evaluate the stability of the blunted PTH response to vitamin D deficiency over 6 months.	Vitamin D	193-202	parathyroid hormone	Homo sapiens	177-180
19213756-0	2009	Relationship between vitamin D, calcium and parathyroid hormone in Cape Town.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	44-63
19213756-1	2009	AIM: The aim of this study was to test the hypothesis that vitamin D deficiency is associated with abnormal levels of calcium and parathyroid hormone (PTH).	Vitamin D	59-68	parathyroid hormone	Homo sapiens	130-149
19213756-1	2009	AIM: The aim of this study was to test the hypothesis that vitamin D deficiency is associated with abnormal levels of calcium and parathyroid hormone (PTH).	Vitamin D	59-68	parathyroid hormone	Homo sapiens	151-154
19237542-1	2009	Plasma concentrations of biologically active vitamin D (1,25-(OH)(2)D) are tightly controlled via feedback regulation of renal 1alpha-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.	Vitamin D	45-54	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	147-154
19217213-0	2009	Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians.	Vitamin D	5-14	insulin	Homo sapiens	54-61
19217213-6	2009	Controlled studies should assess the impact of optimal vitamin D supplementation, with or without added calcium, on risk factors associated with insulin resistance in Asian Indians, as well as in other highly pigmented urbanized ethnic groups that are at high risk for insulin resistance and obesity.	Vitamin D	55-64	insulin	Homo sapiens	145-152
19555519-0	2009	Vitamin D: emerging new roles in insulin sensitivity.	Vitamin D	0-9	insulin	Homo sapiens	33-40
19555519-3	2009	Several clinical intervention studies also support that vitamin D, or its active metabolite 1,25-dihydroxyvitamin D (1,25(OH)2D), improves insulin sensitivity, even in subjects with glucose metabolism parameters classified within normal ranges.	Vitamin D	56-65	insulin	Homo sapiens	139-146
19555519-6	2009	Thus, substantial evidence supports a relationship between vitamin D status and insulin sensitivity; however, the underlying mechanisms require further exploration.	Vitamin D	59-68	insulin	Homo sapiens	80-87
19321461-12	2009	Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.	Vitamin D	20-29	interleukin 6	Homo sapiens	107-111
19193728-3	2009	The mechanism whereby 1,25(OH)(2)D(3) transcriptionally suppresses renin gene expression has been elucidated; however, how vitamin D regulates AGT remains unknown.	Vitamin D	123-132	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	143-146
19193728-9	2009	In mice lacking the vitamin D receptor, AGT mRNA expression in the kidney was markedly increased compared with wild-type mice, and AGT induction in diabetic mice was suppressed by treatment with a vitamin D analog.	Vitamin D	20-29	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	40-43
19193728-9	2009	In mice lacking the vitamin D receptor, AGT mRNA expression in the kidney was markedly increased compared with wild-type mice, and AGT induction in diabetic mice was suppressed by treatment with a vitamin D analog.	Vitamin D	20-29	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	131-134
18834982-0	2009	1,25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter.	Vitamin D	14-23	vascular endothelial growth factor A	Homo sapiens	35-39
18834982-0	2009	1,25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter.	Vitamin D	14-23	vascular endothelial growth factor A	Homo sapiens	95-99
18834982-1	2009	In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)(2)D(3)) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro.	Vitamin D	65-74	vascular endothelial growth factor A	Homo sapiens	103-137
18834982-1	2009	In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)(2)D(3)) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro.	Vitamin D	65-74	vascular endothelial growth factor A	Homo sapiens	139-143
18834982-4	2009	We performed promoter transactivation analysis and we observed that, in 293T cells, VEGF promoter was activated after vitamin D treatment.	Vitamin D	118-127	vascular endothelial growth factor A	Homo sapiens	84-88
18834982-7	2009	These results could explain part of the beneficial effects of vitamin D treatment in renal patients by a possible VEGF-mediated improvement of the endothelial dysfunction.	Vitamin D	62-71	vascular endothelial growth factor A	Homo sapiens	114-118
19076060-0	2009	Role of vitamin D in up-regulating VEGF and reducing the risk of pre-eclampsia.	Vitamin D	8-17	vascular endothelial growth factor A	Homo sapiens	35-39
19188028-1	2009	There is suggestive evidence that chronic elevations of parathyroid hormone (PTH), associated with poor vitamin D status or low calcium intake, can increase risk for insulin resistance, weight gain, hypertension, and left ventricular hypertrophy, while stimulating production of acute phase reactants.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	56-75
18285809-1	2009	BACKGROUND/OBJECTIVES: Vitamin D is required for bone growth and normal insulin secretion.	Vitamin D	23-32	insulin	Homo sapiens	72-79
18285809-3	2009	We have related maternal vitamin D status in pregnancy to maternal and newborn glucose and insulin concentrations, and newborn size, in a South Indian population.	Vitamin D	25-34	insulin	Homo sapiens	91-98
19241329-2	2009	We hypothesized whether the cyclic course of vitamin D levels can be modelled with sunshine duration and would affect parathyroid hormone concentrations, but not calcium in a large patient population.	Vitamin D	45-54	parathyroid hormone	Homo sapiens	118-137
19129794-5	2009	Both 1,25(OH)(2) vitamin D and fibroblast growth factor 23 inhibit PTH gene expression and secretion.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	67-70
19390750-1	2009	OBJECTIVE: To elucidate the association between vitamin D status, C-reactive protein (CRP) and fibrinogen.	Vitamin D	48-57	C-reactive protein	Homo sapiens	86-89
19390750-1	2009	OBJECTIVE: To elucidate the association between vitamin D status, C-reactive protein (CRP) and fibrinogen.	Vitamin D	48-57	fibrinogen beta chain	Homo sapiens	95-105
19188028-1	2009	There is suggestive evidence that chronic elevations of parathyroid hormone (PTH), associated with poor vitamin D status or low calcium intake, can increase risk for insulin resistance, weight gain, hypertension, and left ventricular hypertrophy, while stimulating production of acute phase reactants.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	77-80
19154546-3	2009	Our aim was to investigate differences in serum IgE concentrations by vitamin D status [measured by 25(OH)D] and by a genetic variation in a key vitamin D activation enzyme (CYP27B1) previously shown to be associated with type 1 diabetes.	Vitamin D	145-154	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	174-181
19395331-3	2009	Vitamin D has important physiological effects aside from its effects on bone metabolism, including an important role in glucose homeostasis, insulin release and response.	Vitamin D	0-9	insulin	Homo sapiens	141-148
19389235-2	2009	Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils.	Vitamin D	30-39	cathelicidin antimicrobial peptide	Homo sapiens	109-114
19389235-3	2009	Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness.	Vitamin D	31-40	cathelicidin antimicrobial peptide	Homo sapiens	52-57
19389235-10	2009	It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status.	Vitamin D	51-60	cathelicidin antimicrobial peptide	Homo sapiens	79-84
19389235-10	2009	It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status.	Vitamin D	51-60	cathelicidin antimicrobial peptide	Homo sapiens	115-120
19389235-10	2009	It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status.	Vitamin D	148-157	cathelicidin antimicrobial peptide	Homo sapiens	79-84
19389235-10	2009	It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status.	Vitamin D	148-157	cathelicidin antimicrobial peptide	Homo sapiens	115-120
19299728-1	2009	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP).	Vitamin D	19-28	cathelicidin antimicrobial peptide	Homo sapiens	110-144
19116788-7	2009	The cell specific regulation of CYP19A1 by vitamin D, dexamethasone, and mifepristone opens the possibility for cellular selective modulation of estrogen biosynthesis within the brain.	Vitamin D	43-52	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	32-39
19329830-3	2009	Vitamin D suppresses the renin-angiotensin system, increases insulin secretion and sensitivity, protects against cardiac hypertrophy, and increases left ventricular contraction.	Vitamin D	0-9	renin	Homo sapiens	25-30
19320717-5	2009	Although the PPAR-alpha knockout had no significant effect on molar morphology, the results suggest that active PPAR-alpha signaling is required to achieve normal mineralization of molar enamel, most probably through regulation of calcium homeostasis and metabolism of vitamin D.	Vitamin D	269-278	peroxisome proliferator activated receptor alpha	Mus musculus	112-122
19320717-6	2009	Cyp27b1 was expressed in tooth germ, suggesting that tooth germ can synthesize active vitamin D.	Vitamin D	86-95	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	0-7
19019181-0	2009	Factors associated with elevated or blunted PTH response in vitamin D insufficient adults.	Vitamin D	60-69	parathyroid hormone	Homo sapiens	44-47
19019181-1	2009	OBJECTIVES: The purpose of this study was to examine factors associated with high or low parathyroid hormone (PTH) levels in relationship to vitamin D insufficiency.	Vitamin D	141-150	parathyroid hormone	Homo sapiens	89-108
19019181-1	2009	OBJECTIVES: The purpose of this study was to examine factors associated with high or low parathyroid hormone (PTH) levels in relationship to vitamin D insufficiency.	Vitamin D	141-150	parathyroid hormone	Homo sapiens	110-113
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	12-21	toll like receptor 2	Homo sapiens	52-58
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	12-21	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	182-189
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	154-163	toll like receptor 2	Homo sapiens	52-58
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	154-163	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	182-189
19122196-1	2009	The nuclear receptor vitamin D receptor (VDR) is known to associate with three vitamin D response element (VDREs)-containing regions within the CDKN1A (p21) gene region.	Vitamin D	21-30	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-150
19370277-13	2009	Patients with vitamin D deficiency had significant differences in body mass index (p=0.003), metabolic syndrome (p=0.05), high sensitive C-reactive protein (p=0.009), microalbuminuria (p=0.04), and glumerular filtration rate (p=0.02), compared to patients with sufficient vitamin D.	Vitamin D	14-23	C-reactive protein	Homo sapiens	137-155
19122196-1	2009	The nuclear receptor vitamin D receptor (VDR) is known to associate with three vitamin D response element (VDREs)-containing regions within the CDKN1A (p21) gene region.	Vitamin D	21-30	cyclin dependent kinase inhibitor 1A	Homo sapiens	152-155
19005165-1	2009	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), is a potent inducer of the antimicrobial protein cathelicidin, CAMP (LL37).	Vitamin D	19-28	cathelicidin antimicrobial peptide	Homo sapiens	133-137
18243368-0	2009	Responses of parathyroid hormone to vitamin D supplementation: a systematic review of clinical trials.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	13-32
18243368-2	2009	In this systematic review, we have analyzed the results of 52 clinical trials, including 72 intervention groups and 6290 patients, on vitamin D supplementation in order to evaluate the experimental evidence and the effects of age and chronic immobility on responses of parathyroid hormone (PTH).	Vitamin D	134-143	parathyroid hormone	Homo sapiens	269-288
18243368-7	2009	The vitamin D supplementation of the chronically immobile patients resulted in a smaller decrease in PTH levels (-8.4 vs. -17.4%, p&lt;0.001) despite a larger increase in 25-OHD levels (187.2% vs. 109.8%, p&lt;0.001).	Vitamin D	4-13	parathyroid hormone	Homo sapiens	101-104
18243368-9	2009	This meta-analysis shows that responses of PTH to vitamin D supplementation are not only determined by the baseline PTH levels and changes in vitamin D status, but also by age and mobility of the patients.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	43-46
18243368-9	2009	This meta-analysis shows that responses of PTH to vitamin D supplementation are not only determined by the baseline PTH levels and changes in vitamin D status, but also by age and mobility of the patients.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	116-119
18243368-9	2009	This meta-analysis shows that responses of PTH to vitamin D supplementation are not only determined by the baseline PTH levels and changes in vitamin D status, but also by age and mobility of the patients.	Vitamin D	142-151	parathyroid hormone	Homo sapiens	43-46
18243368-10	2009	Our results also suggest that PTH decreases quite linearly during vitamin D supplementation at any given 25-OHD level.	Vitamin D	66-75	parathyroid hormone	Homo sapiens	30-33
18243368-12	2009	In determining the sufficient doses of vitamin D supplementation and adequate 25-OHD levels, these confounding effects and the inter-individual variation in responses of PTH to vitamin D supplementation should be taken into account.	Vitamin D	177-186	parathyroid hormone	Homo sapiens	170-173
19005165-5	2009	Also consistent with macrophages, induction of trophoblastic CAMP was enhanced via intracrine conversion of 25OHD to 1,25(OH)(2)D. However, in contrast to macrophages, induction of CAMP by vitamin D in trophoblasts was not enhanced by costimulation with Toll-like receptor ligands, such as lipopolysaccharide.	Vitamin D	189-198	cathelicidin antimicrobial peptide	Homo sapiens	61-65
19005165-5	2009	Also consistent with macrophages, induction of trophoblastic CAMP was enhanced via intracrine conversion of 25OHD to 1,25(OH)(2)D. However, in contrast to macrophages, induction of CAMP by vitamin D in trophoblasts was not enhanced by costimulation with Toll-like receptor ligands, such as lipopolysaccharide.	Vitamin D	189-198	cathelicidin antimicrobial peptide	Homo sapiens	181-185
19492580-6	2009	The mother-infant pairs underwent concurrent clinical, biochemical and hormonal evaluation for calcium-vitamin D-PTH axis.	Vitamin D	103-112	parathyroid hormone	Homo sapiens	113-116
19258546-4	2009	After 6 months of treatment, Bax expression along the full lengths of crypts increased 56% (P = 0.02) in the vitamin D group and 33% in both the calcium (P = 0.31) and calcium plus vitamin D (P = 0.36) groups relative to the placebo group.	Vitamin D	109-118	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32
19258546-4	2009	After 6 months of treatment, Bax expression along the full lengths of crypts increased 56% (P = 0.02) in the vitamin D group and 33% in both the calcium (P = 0.31) and calcium plus vitamin D (P = 0.36) groups relative to the placebo group.	Vitamin D	181-190	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32
19371802-3	2009	Activated vitamin D, a hormone produced by the proximal convoluted tubule of the kidney, appears to have beneficial effects beyond suppressing parathyroid hormone (PTH).	Vitamin D	10-19	parathyroid hormone	Homo sapiens	143-162
19116321-2	2009	Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide polymorphisms (SNPs) on 25(OH)D concentrations is unclear.	Vitamin D	56-65	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
19187564-12	2009	Randomized controlled clinical trials, including different therapeutic strategies to lower PTH, e.g. calcium/vitamin D supplementation and weight reduction, are necessary to explore any cause-and-effect relationship.	Vitamin D	109-118	parathyroid hormone	Homo sapiens	91-94
19133797-1	2009	BACKGROUND: Human cathelicidin antimicrobial protein (hCAP18) is an antimicrobial and immunomodulatory peptide that has pleiotropic effects and is transcriptionally regulated by vitamin D.	Vitamin D	178-187	cathelicidin antimicrobial peptide	Homo sapiens	54-60
19133797-2	2009	Because the administration of vitamin D analogues has been linked to decreased mortality among patients with end-stage renal disease, we hypothesized that low hCAP18 levels would identify those who are at increased risk of death attributable to infection while undergoing hemodialysis.	Vitamin D	30-39	cathelicidin antimicrobial peptide	Homo sapiens	159-165
19133797-8	2009	CONCLUSIONS: In individuals initiating chronic hemodialysis, low baseline levels of hCAP18, a vitamin D-regulated antimicrobial protein, are independently associated with an increased risk of death attributable to infection.	Vitamin D	94-103	cathelicidin antimicrobial peptide	Homo sapiens	84-90
19116321-10	2009	These DBP polymorphisms explained as much of the variation in circulating 25(OH)D as did total vitamin D intake (r2 = 1.3% for DBP-1, r2 = 2.0% for DBP-2, and r2 &lt; or = 1.2% for vitamin D intake).	Vitamin D	181-190	D-box binding PAR bZIP transcription factor	Homo sapiens	6-9
19116321-12	2009	Whether DBP rare allele carriers have a different risk of vitamin D-related diseases and whether such carriers can benefit more or less from dietary interventions, vitamin D supplementation, or sun exposure need to be clarified.	Vitamin D	58-67	D-box binding PAR bZIP transcription factor	Homo sapiens	8-11
18979202-1	2009	Better understanding of the physiological role of the vitamin-D system, in particular its potential effects on inflammatory and autoimmune conditions as well as on insulin secretion and possibly also on insulin resistance, increased the interest in its potential role in prevention and control of the diabetic condition, both type-1 and -2 diabetes.	Vitamin D	54-63	insulin	Homo sapiens	164-171
18927213-8	2009	Compared with mice fed regular chow, vitamin D-deprived BALB/c mice had fewer splenic B cells and decreased interferon-gamma responses to mitogen and lacked memory T-cell responses to A-subunit protein.	Vitamin D	37-46	interferon gamma	Mus musculus	108-124
18979202-1	2009	Better understanding of the physiological role of the vitamin-D system, in particular its potential effects on inflammatory and autoimmune conditions as well as on insulin secretion and possibly also on insulin resistance, increased the interest in its potential role in prevention and control of the diabetic condition, both type-1 and -2 diabetes.	Vitamin D	54-63	insulin	Homo sapiens	203-210
19106328-9	2009	Among adults without diabetes, vitamin D status was inversely associated with surrogate fasting measures of insulin resistance.	Vitamin D	31-40	insulin	Homo sapiens	108-115
18523928-0	2009	Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications.	Vitamin D	98-107	solute carrier family 34 member 3	Homo sapiens	64-71
18523928-0	2009	Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications.	Vitamin D	98-107	solute carrier family 34 member 3	Homo sapiens	72-80
18683889-5	2009	Treatment of dermal fibroblasts with vitamin D(3) induced expression of BMP-4 (1.2 +/- 0.2, 1.7 +/- 0.2, and 1.8 +/- 0.2 relative fold increase) and BMP-6 (9.1 +/- 0.3, 23.3 +/- 2.1, and 30.4 +/- 3.0 relative fold increase) at 3, 14, and 21 days, respectively.	Vitamin D	37-46	bone morphogenetic protein 6	Homo sapiens	149-154
18981260-5	2009	The degree of the PXR-mediated locking of SMRT depends on the relative concentration of vitamin D(3) to the human PXR activator rifampicin; SMRT increased its dissociation as this ratio increased.	Vitamin D	88-97	nuclear receptor subfamily 1 group I member 2	Homo sapiens	18-21
18981260-7	2009	Thus, our present study defines the novel molecular mechanism by which PXR and CAR mediate drug interactions with vitamin D(3) to regulate the CYP24A1 gene.	Vitamin D	114-123	nuclear receptor subfamily 1, group I, member 3	Mus musculus	79-82
19270204-3	2009	Several factors have been implicated in the pathogenesis of insulin resistance, including anemia, dyslipidemia, uremia, malnutrition, excess of parathyroid hormone, vitamin D deficiency, metabolic acidosis, and increase in plasma free fatty acids and proinflammatory cytokines.	Vitamin D	165-174	insulin	Homo sapiens	60-67
19098224-4	2009	Consistent with this, VDR and SMRT are recruited to the vitamin D response element of the endogenous osteocalcin promoter in the absence of 1alpha,25-(OH)(2)D(3) in chromatin immunoprecipitation assays.	Vitamin D	56-65	bone gamma-carboxyglutamate protein	Homo sapiens	101-112
19074549-2	2009	1,25(OH)(2) vitamin D(3) [1alpha,25(OH)(2)D(3)] has antiproliferative effects on osteosarcoma cells, and a complex interregulatory situation exists between PRL and 1alpha,25(OH)(2)D(3).	Vitamin D	12-21	prolactin	Homo sapiens	156-159
19197344-0	2009	Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D.	Vitamin D	98-107	major histocompatibility complex, class II, DR beta 1	Homo sapiens	68-76
19197344-5	2009	Sequence analysis localised a single MHC vitamin D response element (VDRE) to the promoter region of HLA-DRB1.	Vitamin D	41-50	major histocompatibility complex, class II, DR beta 1	Homo sapiens	101-109
19197344-11	2009	Flow cytometric analysis showed a specific increase in the cell surface expression of HLA-DRB1 upon addition of vitamin D only in HLA-DRB1*15 bearing lymphoblastoid cells.	Vitamin D	112-121	major histocompatibility complex, class II, DR beta 1	Homo sapiens	86-94
19197344-11	2009	Flow cytometric analysis showed a specific increase in the cell surface expression of HLA-DRB1 upon addition of vitamin D only in HLA-DRB1*15 bearing lymphoblastoid cells.	Vitamin D	112-121	major histocompatibility complex, class II, DR beta 1	Homo sapiens	130-138
19125756-1	2009	AIM: To determine the short-term effect of vitamin D(3) supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men.	Vitamin D	43-52	insulin	Homo sapiens	75-82
19642305-4	2009	Overproduction of cytokines IL-1 alpha, IL-1 beta and TNF-alpha increases bone resorption, which is further accelerated by hyperparathyroidism connected with malabsorption of calcium and vitamin D.	Vitamin D	187-196	tumor necrosis factor	Homo sapiens	54-63
22461093-5	2009	Further examples include screening the presence of the HLA-B*5701 allele to prevent the hypersensitivity reactions to abacavir and the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therapy of breast cancer or that of KRAS mutation status for cetuximab or panitumumab therapy in colorectal cancer.Moreover, the application of pharmacogenetics and pharmacogenomics to therapies used in the treatment of osteoarticular diseases (e.g. rheumatoid arthritis, osteoporosis) holds great promise for tailoring therapy with clinically relevant drugs (e.g. disease-modifying antirheumatic drugs, vitamin D, and estrogens).	Vitamin D	631-640	erb-b2 receptor tyrosine kinase 2	Homo sapiens	193-198
19178708-2	2009	Potential mechanisms include involvement of vitamin D in regulation of renin-angiotensin system and manufacture and secretion of cardiac natriuretic peptides.	Vitamin D	44-53	renin	Homo sapiens	71-76
19139017-10	2009	Reverse transcription-PCR analysis showed significant up-regulation of VDR and E-cadherin, a downstream target of vitamin D action.	Vitamin D	114-123	cadherin 1	Homo sapiens	79-89
19063829-2	2009	Emerging evidence indicates that vitamin D-mediated innate immunity, particularly through enhanced expression of the human cathelicidin antimicrobial peptide (hCAP-18), is important in host defenses against respiratory tract pathogens.	Vitamin D	33-42	cathelicidin antimicrobial peptide	Homo sapiens	123-157
19063829-2	2009	Emerging evidence indicates that vitamin D-mediated innate immunity, particularly through enhanced expression of the human cathelicidin antimicrobial peptide (hCAP-18), is important in host defenses against respiratory tract pathogens.	Vitamin D	33-42	cathelicidin antimicrobial peptide	Homo sapiens	159-166
18762977-1	2009	Turkey, especially its eastern part, has been accepted as endemic for vitamin D deficiency rickets (VDDR).	Vitamin D	70-79	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	100-104
18762977-3	2009	In 2005, the Ministry of Health initiated a free vitamin D supplementation campaign nationwide for every infant to eradicate VDDR.	Vitamin D	49-58	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	125-129
18762977-11	2009	It was concluded that, although VDDR has been a continuing childhood health problem, a nationwide free vitamin D supplementation campaign initiated by the government appeared to be effective in eliminating VDDR.	Vitamin D	103-112	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	206-210
18854395-2	2009	These nonclassic tissues are therefore potential targets for the active metabolite of vitamin D, 1,25(OH)(2)D. Furthermore, many of these tissues also contain the enzyme CYP27B1 capable of producing 1,25(OH)(2)D from the circulating form of vitamin D.	Vitamin D	86-95	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	170-177
19371198-11	2009	While animal studies and smaller interventional trials in humans suggest that vitamin D supplementation improves measures of insulin sensitivity and glucose tolerance, larger interventional trials are warranted to determine if vitamin D treatment at adequate doses can prevent diabetes.	Vitamin D	78-87	insulin	Homo sapiens	125-132
18854395-2	2009	These nonclassic tissues are therefore potential targets for the active metabolite of vitamin D, 1,25(OH)(2)D. Furthermore, many of these tissues also contain the enzyme CYP27B1 capable of producing 1,25(OH)(2)D from the circulating form of vitamin D.	Vitamin D	241-250	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	170-177
19287183-3	2009	Vitamin D suppresses parathyroid hormone (PTH) secretion in part through its action on the vitamin D receptor.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	21-40
21274306-0	2009	The effect of vitamin D treatment on serum adiponectin levels in children with vitamin D deficiency rickets.	Vitamin D	14-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
21274306-0	2009	The effect of vitamin D treatment on serum adiponectin levels in children with vitamin D deficiency rickets.	Vitamin D	79-88	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
21274306-2	2009	The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR).	Vitamin D	55-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	82-93
21274306-2	2009	The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR).	Vitamin D	55-64	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	148-152
21274306-2	2009	The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR).	Vitamin D	118-127	adiponectin, C1Q and collagen domain containing	Homo sapiens	82-93
21274306-2	2009	The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR).	Vitamin D	118-127	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	148-152
18957950-0	2009	Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift?	Vitamin D	17-26	parathyroid hormone	Homo sapiens	51-70
19668299-2	2009	Namely, the use of calcium- based binders in combination with vitamin D analogues, has been shown to lead to an over-suppression of parathyroid hormone (PTH) and development of low-bone turnover adynamic bone disease (ABD).	Vitamin D	62-71	parathyroid hormone	Homo sapiens	132-151
19240808-5	2009	In the past few years, research has revealed new and mostly unsuspected roles for SXR in modulating inflammation, bone homeostasis, vitamin D metabolism, lipid homeostasis, energy homeostasis and cancer.	Vitamin D	132-141	nuclear receptor subfamily 1 group I member 2	Homo sapiens	82-85
19142273-2	2008	More recently, the nonmusculoskeletal actions of vitamin D have become increasingly documented including endocrine effect on kidneys and intestine, local autocrine effects on cell differentiation, proliferation and immune modulation, and cell membrane effects including promotion of the intestinal absorption of calcium and the secretion of insulin.	Vitamin D	49-58	insulin	Homo sapiens	341-348
19055985-3	2008	Vitamin D deficiency activates the renin-angiotensin-aldosterone system and can predispose to hypertension and left ventricular hypertrophy.	Vitamin D	0-9	renin	Homo sapiens	35-40
19055985-4	2008	Additionally, vitamin D deficiency causes an increase in parathyroid hormone, which increases insulin resistance and is associated with diabetes, hypertension, inflammation, and increased cardiovascular risk.	Vitamin D	14-23	insulin	Homo sapiens	94-101
19235038-2	2009	The association between elevated parathyroid hormone (PTH) and low 25-hydroxyvitamin D (25-OH-VitD) in plasma is used to define vitamin D deficiency, yet their associated mechanistic pathways are unclear.	Vitamin D	77-86	parathyroid hormone	Homo sapiens	33-52
20169924-1	2009	Vitamin D-binding protein (DBP) participates in the actin scavenger system, it is a carrier of vitamin D and its derivatives, it manifests the capacity to bind mainly monounsaturated and saturated fatty acids, it binds to the surface of several cells and enhances chemotactic activity of C5a of the complement.	Vitamin D	95-104	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
19034301-2	2008	Here we separated the role of vitamin D and parathyroid hormone in the regulation of renin expression in vivo by generating transgenic mice that overexpressed the human vitamin D receptor in renin-producing cells using the 4.1 kb Ren-1c gene promoter.	Vitamin D	30-39	renin	Homo sapiens	85-90
18829467-1	2008	FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion.	Vitamin D	170-179	fibroblast growth factor 21	Homo sapiens	33-38
18518931-1	2008	AIM: Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	5-24
19040987-11	2008	Vit D status affects gland size and postoperative PTH elevation.	Vitamin D	0-5	parathyroid hormone	Homo sapiens	50-53
18981129-9	2008	In contrast to induction of the antimicrobial peptide, vitamin D attenuates dsRNA-induced expression of the NF-kappaB-driven gene IL-8.	Vitamin D	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
19098950-0	2008	Vitamin D insufficiency in New Zealanders during the winter is associated with higher parathyroid hormone concentrations: implications for bone health?	Vitamin D	0-9	parathyroid hormone	Homo sapiens	86-105
19098950-1	2008	BACKGROUND: Parathyroid hormone concentration (PTH) is elevated in vitamin D insufficiency and when prolonged, this condition leads to reduced bone mass and possibly osteoporosis.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	12-31
19098950-1	2008	BACKGROUND: Parathyroid hormone concentration (PTH) is elevated in vitamin D insufficiency and when prolonged, this condition leads to reduced bone mass and possibly osteoporosis.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	47-50
19098950-2	2008	The threshold of 25-hydroxyvitamin D above which PTH plateaus, is a criterion often used to define vitamin D adequacy.	Vitamin D	27-36	parathyroid hormone	Homo sapiens	49-52
19098950-3	2008	AIMS: To determine whether the higher rates of vitamin D inadequacy reported in the winter than summer months in New Zealand also result in higher PTH concentrations.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	147-150
19015318-0	2008	RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.	Vitamin D	35-44	mitogen-activated protein kinase 14	Homo sapiens	14-21
18981132-0	2008	IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.	Vitamin D	61-70	toll like receptor 2	Homo sapiens	12-18
18981132-2	2008	In humans, one such pathway involves activation by TLR2/1L leading to the vitamin D-dependent induction of antimicrobial peptides.	Vitamin D	74-83	toll like receptor 2	Homo sapiens	51-58
18981132-6	2008	Therefore, IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.	Vitamin D	72-81	toll like receptor 2	Homo sapiens	23-29
18948436-0	2008	Vitamin D may reduce prostate cancer metastasis by several mechanisms including blocking Stat3.	Vitamin D	0-9	signal transducer and activator of transcription 3	Homo sapiens	89-94
18928396-6	2008	Furthermore, the effect of vitamin D status on CD4 cell recovery after initiation of HAART will be evaluated.	Vitamin D	27-36	CD4 molecule	Homo sapiens	47-50
18928396-16	2008	Evaluation of 25(OH)D(3) and PTH levels, especially in NNRTI-treated and dark skinned HIV-1-infected patients, is necessary to detect and treat vitamin D deficiency early.	Vitamin D	144-153	parathyroid hormone	Homo sapiens	29-32
18463127-1	2008	AIMS: The purpose of this study was to assess the vitamin D status of children with renal disease attending the outpatient clinics of our tertiary nephrology centre, allowing us to determine the prevalence of vitamin D deficiency and study its relationship with glomerular filtration rate (GFR) and serum parathyroid hormone (PTH) concentration.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	305-324
18852718-3	2008	Low serum vitamin D levels are common in the general population and cause a decline in calcium absorption, leading to low serum levels of ionized calcium, which in turn trigger the release of parathyroid hormone, promoting skeletal resorption and, eventually, bone loss or osteomalacia.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	192-211
19138995-0	2008	Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.	Vitamin D	7-16	estrogen receptor 1	Homo sapiens	35-52
19138995-0	2008	Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.	Vitamin D	7-16	estrogen receptor 1	Homo sapiens	66-83
19138995-5	2008	In vivo experiments were designed to study the inhibitory effect of selected Gemini vitamin D analogues against mammary carcinogenesis by using (a) an N-methyl-N-nitrosourea-induced estrogen receptor (ER)-positive mammary tumor model and (b) an MCF10DCIS.com xenograft model of ER-negative mammary tumors.	Vitamin D	84-93	estrogen receptor 1	Homo sapiens	182-199
19138995-5	2008	In vivo experiments were designed to study the inhibitory effect of selected Gemini vitamin D analogues against mammary carcinogenesis by using (a) an N-methyl-N-nitrosourea-induced estrogen receptor (ER)-positive mammary tumor model and (b) an MCF10DCIS.com xenograft model of ER-negative mammary tumors.	Vitamin D	84-93	estrogen receptor 1	Homo sapiens	201-203
19138995-9	2008	Our results suggest that Gemini vitamin D analogues may be potent agents for the prevention and treatment of both ER-positive and ER-negative breast cancer without hypercalcemia toxicity.	Vitamin D	32-41	estrogen receptor 1	Homo sapiens	114-116
19138995-9	2008	Our results suggest that Gemini vitamin D analogues may be potent agents for the prevention and treatment of both ER-positive and ER-negative breast cancer without hypercalcemia toxicity.	Vitamin D	32-41	estrogen receptor 1	Homo sapiens	130-132
19018724-3	2008	The regulatory function of PXR is implicated in normal physiology and diseases, such as drug-drug interactions, hepatic steatosis, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory bowel diseases.	Vitamin D	131-140	nuclear receptor subfamily 1 group I member 2	Homo sapiens	27-30
19179799-2	2008	METHODS: A T869--&gt;C polymorphism in exon 1 of the transforming growth factor-beta1 gene, which results in a Leu--&gt;Pro substitution at amino acid 10, is reported to be associated with the rate of bone loss as well as the response to active vitamin D treatment.	Vitamin D	245-254	transforming growth factor beta 1	Homo sapiens	53-85
18616960-2	2008	Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than the native hormone are preferred therapies for secondary hyperparathyroidism.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	54-57
18832725-5	2008	Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors.	Vitamin D	39-48	MAF bZIP transcription factor B	Homo sapiens	129-133
18832725-5	2008	Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors.	Vitamin D	39-48	MAF bZIP transcription factor B	Homo sapiens	255-259
18832725-6	2008	Altogether, these data allow one to conclude that the vitamin D(3)/Hox-A10 pathway supports MafB function during the induction of monocyte differentiation.	Vitamin D	54-63	MAF bZIP transcription factor B	Homo sapiens	92-96
18539154-6	2008	The immunoexpression of tumor suppressor p53 and downregulation of antiapoptotic protein BCl-2 in subsequent immunofluorescence assay further provide strong evidence for the combinatorial inhibitory actions of vanadium and vitamin D(3) against DMH-induced rat colon carcinogenesis.	Vitamin D	223-232	BCL2, apoptosis regulator	Rattus norvegicus	89-94
18821289-1	2008	INTRODUCTION: It was found that vitamin D may have a direct effect on adipocyte differentiation and metabolism and might be involved in the glucose regulation of insulin secretion, as suggested from the discovery of a nuclear localization of 1,25-(OH)(2)D(3) in pancreatic islets.	Vitamin D	32-41	insulin	Homo sapiens	162-169
18778589-5	2008	Glycemic control and insulin resistance are improved when vitamin D deficiency is corrected and calcium supplementation is adequate.	Vitamin D	58-67	insulin	Homo sapiens	21-28
18555765-12	2008	Therefore, GS is a strategic enzyme in controlling glutamate concentration in bone environment: GCs decreased the amount of this signalling molecule while vitamin D and Wnt signalling pathway increased it.	Vitamin D	155-164	glutamate-ammonia ligase	Homo sapiens	11-13
19035286-4	2008	Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression.	Vitamin D	52-61	cadherin 1	Homo sapiens	248-258
25983966-4	2008	Recent studies showed that the combination of PEIT and intravenous vitamin D pulse therapy lead to reduce serum PTH level and calcium-phosphorus products in haemodialysis patients.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	112-115
18400968-2	2008	The vitamin D receptor is distributed ubiquitously, and by binding with its receptor, vitamin D initiates a series of events that can affect cellular proliferation and differentiation, inflammation, the immune system, and the endocrine system, including the renin-angiotensin system, insulin resistance, and lipid metabolism.	Vitamin D	4-13	renin	Homo sapiens	258-263
18400968-2	2008	The vitamin D receptor is distributed ubiquitously, and by binding with its receptor, vitamin D initiates a series of events that can affect cellular proliferation and differentiation, inflammation, the immune system, and the endocrine system, including the renin-angiotensin system, insulin resistance, and lipid metabolism.	Vitamin D	4-13	insulin	Homo sapiens	284-291
18958772-1	2008	AIM: Vitamin D could have a direct effect on adipocyte differentiation and metabolism and might be involved in glucose regulation of insulin secretion.	Vitamin D	5-14	insulin	Homo sapiens	133-140
18721734-3	2008	The present study investigates the impact of DBP polymorphism on the need for vitamin D in hemodialysis patients.	Vitamin D	78-87	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
18721734-13	2008	The need for oral vitamin D differed significantly (P &lt; .01) between DBP phenotypes, and was greatest in DBP 2-2.	Vitamin D	18-27	D-box binding PAR bZIP transcription factor	Homo sapiens	72-75
18721734-13	2008	The need for oral vitamin D differed significantly (P &lt; .01) between DBP phenotypes, and was greatest in DBP 2-2.	Vitamin D	18-27	D-box binding PAR bZIP transcription factor	Homo sapiens	108-111
18721734-15	2008	More importantly, vitamin D intake differs depending on the DBP polymorphism, and is greatest for end-stage renal disease patients with a DBP 2-2 phenotype.	Vitamin D	18-27	D-box binding PAR bZIP transcription factor	Homo sapiens	60-63
18721734-15	2008	More importantly, vitamin D intake differs depending on the DBP polymorphism, and is greatest for end-stage renal disease patients with a DBP 2-2 phenotype.	Vitamin D	18-27	D-box binding PAR bZIP transcription factor	Homo sapiens	138-141
18721734-16	2008	Therefore, vitamin D treatment deserves more careful monitoring among DBP 2-2 patients with end-stage renal disease.	Vitamin D	11-20	D-box binding PAR bZIP transcription factor	Homo sapiens	70-73
18602086-0	2008	Identification of the functional vitamin D response elements in the human MDR1 gene.	Vitamin D	33-42	ATP binding cassette subfamily B member 1	Homo sapiens	74-78
18602086-7	2008	Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs).	Vitamin D	186-195	TNF receptor superfamily member 25	Homo sapiens	82-85
18689390-4	2008	The vitamin D biomarkers that have shown the most utility to date are the plasma concentration of 25-hydroxyvitamin D (supply), the plasma concentration of parathyroid hormone (function), and the presence or absence of rickets (outcome).	Vitamin D	4-13	parathyroid hormone	Homo sapiens	156-175
18463168-2	2008	Among nondialyzed patients with chronic kidney disease (CKD), oral activated vitamin D reduces parathyroid hormone levels, but the impact on clinical outcomes is unknown.	Vitamin D	77-86	parathyroid hormone	Homo sapiens	95-114
18208576-2	2008	However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT).	Vitamin D	50-59	parathyroid hormone	Homo sapiens	30-33
18667086-2	2008	There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes.	Vitamin D	41-50	insulin	Homo sapiens	62-69
18667086-6	2008	DISCUSSION: This randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects.	Vitamin D	93-102	insulin	Homo sapiens	122-129
18649741-2	2008	The enzymes that are responsible for the activation of vitamin D to 1alpha,25(OH)2D include vitamin D-25-hydroxylase (25-OHase) and 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase or CYP27BJ) and are present in cultured prostate cells.	Vitamin D	55-64	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	172-184
18208576-3	2008	AIM: We compared indices of calcium homeostasis, bone metabolism and body composition in subjects with differential PTH responses to low vitamin D levels.	Vitamin D	137-146	parathyroid hormone	Homo sapiens	116-119
18208576-11	2008	CONCLUSIONS: Effects of vitamin D insufficiency on bone is associated with the PTH responses.	Vitamin D	24-33	parathyroid hormone	Homo sapiens	79-82
18567755-1	2008	The major circulating form of vitamin D, 25-hydroxycholecalciferol (25D3), circulates bound to vitamin D-binding protein (DBP).	Vitamin D	30-39	D-box binding PAR bZIP transcription factor	Homo sapiens	122-125
18400938-4	2008	In a prospective cohort of non-Hispanic white (n = 5110), Hispanic white (n = 979), and black (n = 3214) incident hemodialysis patients, higher parathyroid hormone levels at baseline were the primary determinant of prescribing activated vitamin D therapy.	Vitamin D	237-246	parathyroid hormone	Homo sapiens	144-163
18400938-5	2008	Median parathyroid hormone was highest among black patients, who were most likely to receive activated vitamin D and at the highest dosage.	Vitamin D	103-112	parathyroid hormone	Homo sapiens	7-26
18310602-2	2008	The objective of the current study was to determine whether treatment with cinacalcet combined with low doses of vitamin D sterols improves control of both PTH and Ca x P among haemodialysis patients with secondary hyperparathyroidism (sHPT).	Vitamin D	113-122	parathyroid hormone	Homo sapiens	156-159
18038108-3	2008	INTRODUCTION: Vitamin D-binding protein (DBP) plays a critical role in the transport and metabolism of metabolites of vitamin D, including the key calciotropic hormone 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	118-127	D-box binding PAR bZIP transcription factor	Homo sapiens	41-44
18038108-10	2008	This effect may be mediated by changes in the circulating concentrations of DBP which influences free concentrations of vitamin D.	Vitamin D	120-129	D-box binding PAR bZIP transcription factor	Homo sapiens	76-79
18559548-0	2008	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.	Vitamin D	22-31	solute carrier family 25 member 18	Homo sapiens	4-7
18541802-8	2008	We have identified 3 patients with this disease who later developed MS. We propose that VDDR I and possibly other hereditary rickets mutations that influence vitamin D metabolism could be risk factors for this disease.	Vitamin D	158-167	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	88-94
18518851-4	2008	Furthermore, varying responsiveness to vitamin D and estrogen-based treatments may reflect allele variation in their signaling pathway genes (e.g., VDR or ERalpha).	Vitamin D	39-48	estrogen receptor 1	Homo sapiens	155-162
18502116-6	2008	Vitamin D receptor (vdr) and retinoid X receptor alpha (rxralpha), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased.	Vitamin D	135-144	retinoid X receptor alpha	Rattus norvegicus	29-54
18502116-6	2008	Vitamin D receptor (vdr) and retinoid X receptor alpha (rxralpha), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased.	Vitamin D	135-144	retinoid X receptor alpha	Rattus norvegicus	56-64
18519464-10	2008	The inverse relationship between 25-hydroxyvitamin D and parathyroid hormone levels suggests a physiologic impact of insufficient vitamin D levels that may contribute to low bone mass or worsen the primary bone disease.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	57-76
18156462-6	2008	RESULTS: Treatment with any of the vitamin D metabolites and 90-ET significantly decreased the serum intact-PTH level, but only the latter significantly decreased the serum Ca level.	Vitamin D	35-44	parathyroid hormone	Rattus norvegicus	108-111
18411217-8	2008	In vitro analysis showed that vitamin D(3) was found to dose-dependently suppress the protein and mRNA expressions of TLR2 and TLR4.	Vitamin D	30-39	toll like receptor 2	Homo sapiens	118-122
18411217-11	2008	And it seems possible that vitamin D may be used as a therapeutic option by modulating TLR2 and TLR4 expression of monocytes in BD.	Vitamin D	27-36	toll like receptor 2	Homo sapiens	87-91
18080320-0	2008	Two modes of ERK activation by TNF in keratinocytes: different cellular outcomes and bi-directional modulation by vitamin D.	Vitamin D	114-123	mitogen-activated protein kinase 1	Homo sapiens	13-16
18080320-0	2008	Two modes of ERK activation by TNF in keratinocytes: different cellular outcomes and bi-directional modulation by vitamin D.	Vitamin D	114-123	tumor necrosis factor	Homo sapiens	31-34
18426835-14	2008	The long-term prognostic impact of vitamin D deficiency, the most common cause of elevated PTH levels in the elderly, remains to be investigated.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	91-94
18200516-7	2008	Caspase-3 activation and PARP cleavage are registered when PBMC were treated with vitamin D derivatives.	Vitamin D	82-91	caspase 3	Homo sapiens	0-9
18200516-7	2008	Caspase-3 activation and PARP cleavage are registered when PBMC were treated with vitamin D derivatives.	Vitamin D	82-91	poly(ADP-ribose) polymerase 1	Homo sapiens	25-29
18200516-9	2008	The treatment with the vitamin D derivatives, alone or in combination with LPS or TNF-alpha, significantly decreases ICAM-1 levels both in healthy subjects and IBD patients.	Vitamin D	23-32	tumor necrosis factor	Homo sapiens	82-91
18287530-0	2008	Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.	Vitamin D	59-68	claudin 2	Homo sapiens	24-41
18287530-6	2008	These findings strongly suggest that claudin-2- and/or claudin-12-based tight junctions form paracellular Ca(2+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis.	Vitamin D	191-200	claudin 2	Homo sapiens	37-46
18289904-5	2008	PTH was moderately elevated and after 4 months of supplemental therapy with calcium and vitamin D, it decreased to the normal range.	Vitamin D	88-97	parathyroid hormone	Homo sapiens	0-3
18156462-9	2008	CONCLUSIONS: DI of vitamin D metabolites may be effective in controlling not only the PTH level, but also PTG hyperplasia, in advanced SHPT by, at least in part, apoptosis-induced cell death.	Vitamin D	19-28	parathyroid hormone	Rattus norvegicus	86-89
18504173-8	2008	Correlation both with markers of bone metabolism and vitamin D metabolites showed the important role of GH/IGF-I axis in modulating the availability of calcium in chronic conditions.	Vitamin D	53-62	insulin like growth factor 1	Homo sapiens	107-112
18239958-1	2008	UNLABELLED: As the serum calcium and glomerular filtration rate decreased, the proportion of active PTH(1-84) molecules in PTH immunoreactivity increased in serum from predialysis uremic patients, particularly those with vitamin D insufficiency.	Vitamin D	221-230	parathyroid hormone	Homo sapiens	100-103
18239958-1	2008	UNLABELLED: As the serum calcium and glomerular filtration rate decreased, the proportion of active PTH(1-84) molecules in PTH immunoreactivity increased in serum from predialysis uremic patients, particularly those with vitamin D insufficiency.	Vitamin D	221-230	parathyroid hormone	Homo sapiens	123-126
18239958-8	2008	CONCLUSION: As GFR declined with suppression of serum Ca, the proportion of active PTH molecules increased in predialysis CRF patients, particularly those with vitamin D insufficiency.	Vitamin D	160-169	parathyroid hormone	Homo sapiens	83-86
18037293-0	2008	Vitamin D supplementation and response to aromatase inhibitors in postmenopausal women with hormone-receptor positive breast cancer.	Vitamin D	0-9	nuclear receptor subfamily 4 group A member 1	Homo sapiens	92-108
18560026-6	2008	RESULTS: vitamin D inadequacy was found in 61.9% of patients and 34.6% of them or 23.8% of total patients were also having high PTH level.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	128-131
18506273-0	2008	[Prevalence of vitamin D deficiency and its correlation with PTH, biochemical bone turnover markers and bone mineral density, among patients from ambulatories].	Vitamin D	15-24	parathyroid hormone	Homo sapiens	61-64
18353060-2	2008	The aim of the present paper was to measure the effect of vitamin D, in order to see the relation between vitamin D and urinary excretion of deoxypyridinoline (DPD), serum osteocalcin (OC), calcium (Ca), inorganic phosphorus (P), and alkaline phosphatase (ALP).	Vitamin D	106-115	alkaline phosphatase, placental	Homo sapiens	234-254
18393827-6	2008	Vitamin D(3) compounds are known to influence melanocyte maturation and differentiation and also to up-regulate melanogenesis through pathways activated by specific ligand receptors, such as endothelin receptor and c-kit.	Vitamin D	0-9	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	215-220
18077140-1	2008	BACKGROUND: 1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3), the active form of vitamin D, suppresses keratinocyte proliferation, promotes keratinocyte differentiation, and induces involucrin expression.	Vitamin D	32-41	involucrin	Homo sapiens	184-194
18467787-14	2008	CONCLUSION: Mechanical stress and MAPK control CYP24 promoter activity in the presence of Vitamin D in MG63 osteoblast-like cells.	Vitamin D	90-99	mitogen-activated protein kinase 3	Homo sapiens	34-38
18353060-0	2008	Effect of different doses of vitamin D on osteocalcin and deoxypyridinoline in preterm infants.	Vitamin D	29-38	bone gamma-carboxyglutamate protein	Homo sapiens	42-53
18393917-3	2008	Treatment with calcitriol (CT), the active form of vitamin D, reduces parathyroid hormone (PTH) levels, but may result in elevations in serum calcium (Ca) and phosphorus (P), increasing the risk of cardio-vascular calcification in the HD population.	Vitamin D	51-60	parathyroid hormone	Homo sapiens	70-89
18393917-3	2008	Treatment with calcitriol (CT), the active form of vitamin D, reduces parathyroid hormone (PTH) levels, but may result in elevations in serum calcium (Ca) and phosphorus (P), increasing the risk of cardio-vascular calcification in the HD population.	Vitamin D	51-60	parathyroid hormone	Homo sapiens	91-94
18377338-3	2008	OBJECTIVE: Treatment with calcitriol, the active form of vitamin D, reduces serum parathyroid hormone (PTH) levels but may result in both hypercalcemia and hyperphosphatemia, increasing the risk of vascular calcification in CKD.	Vitamin D	57-66	parathyroid hormone	Homo sapiens	82-101
18353060-2	2008	The aim of the present paper was to measure the effect of vitamin D, in order to see the relation between vitamin D and urinary excretion of deoxypyridinoline (DPD), serum osteocalcin (OC), calcium (Ca), inorganic phosphorus (P), and alkaline phosphatase (ALP).	Vitamin D	106-115	alkaline phosphatase, placental	Homo sapiens	256-259
18287084-6	2008	Interestingly, the calcifying arteriopathy of TIF1alpha-null mutant mice shares features with the human age-related Monckeberg"s disease and, overall, the TIF1alpha-null mutant pathological phenotype supports the hypothesis that aging is promoted by increased activity of the vitamin D signaling pathway.	Vitamin D	276-285	tripartite motif-containing 24	Mus musculus	46-55
18304585-0	2008	Predominant role of 25OHD in the negative regulation of PTH expression: clinical relevance for hypovitaminosis D. Although severe deficiency of bioactive vitamin D (1,25OH2D) causes rickets, mild insufficiency of the hormone, known as hypovitaminosis D, is responsible for the occurrence of secondary hyperparathyroidism and osteoporosis.	Vitamin D	154-163	parathyroid hormone	Homo sapiens	56-59
18304585-6	2008	These results suggest that the negative feedback regulation of vitamin D on PTH gene transcription occurs not by the end-product 1,25OH2D but by its prohormone 25OHD via intracellular activation by 1alpha-hydroxylase within the parathyroid cells.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	76-79
18334925-1	2008	INTRODUCTION: Vitamin D-binding protein (also called DBP or Gc-globulin) is recognized as a multifunctional protein involved in the action scavenger system, the transport of vitamin D sterols, and the modulation of immune and inflammatory responses.	Vitamin D	174-183	D-box binding PAR bZIP transcription factor	Homo sapiens	53-56
18565252-16	2008	The resorption activity of the L OA cells was significantly inhibited by all treatments except IL-1Beta, with maximum effect observed with vitamin D(3) and PGE(2).	Vitamin D	139-148	interleukin 1 beta	Homo sapiens	95-103
18187872-6	2008	However, when subjects with the highest serum PTH levels (PTH&gt;1000 pg/ml) were excluded from the analysis, the correlation was significant between serum 25(OH)D levels and PTH, indicating that vitamin D status affects the severity of pHPT when severe cases were excluded.	Vitamin D	196-205	parathyroid hormone	Homo sapiens	46-49
18160466-0	2008	A functional common polymorphism in the vitamin D-responsive element of the GH1 promoter contributes to isolated growth hormone deficiency.	Vitamin D	40-49	growth hormone 1	Homo sapiens	76-79
18187309-2	2008	Possible mechanisms of action of vitamin D include stimulation of insulin secretion and effects on insulin sensitivity.	Vitamin D	33-42	insulin	Homo sapiens	66-73
17342165-0	2008	Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	42-61
18327422-3	2008	We have shown earlier that vitamin D(3) and retinoic acid (RA) down-regulate TACO gene transcription in a dose-dependent manner.	Vitamin D	27-36	coronin 1A	Homo sapiens	77-81
18024243-8	2008	In 39 elderly osteoporotic women on a low calcium intake and given vitamin D supplements (2000-3000 IU daily for &gt;8 months) able to increase 25(OH)D levels above 110 nMol/l, PTH levels were maintained below 35 pg/mL.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	177-180
18245894-3	2008	A T --&gt; C polymorphism in exon 1 of the transforming growth factor-beta 1 gene, which is associated with the rate of bone loss as well as the response to active vitamin D treatment, was used to select high responder to active vitamin D treatment.	Vitamin D	164-173	transforming growth factor beta 1	Homo sapiens	43-76
18245894-3	2008	A T --&gt; C polymorphism in exon 1 of the transforming growth factor-beta 1 gene, which is associated with the rate of bone loss as well as the response to active vitamin D treatment, was used to select high responder to active vitamin D treatment.	Vitamin D	229-238	transforming growth factor beta 1	Homo sapiens	43-76
18327422-6	2008	RESULTS: TACO gene down-regulation observed with vitamin D(3)/RA treatment occurred through modulation of this gene via the VDR/RXR response sequence present in the promoter region of TACO gene.	Vitamin D	49-58	coronin 1A	Homo sapiens	9-13
18327422-6	2008	RESULTS: TACO gene down-regulation observed with vitamin D(3)/RA treatment occurred through modulation of this gene via the VDR/RXR response sequence present in the promoter region of TACO gene.	Vitamin D	49-58	coronin 1A	Homo sapiens	184-188
18327422-8	2008	CONCLUSIONS: Our results elucidate the mechanism of TACO gene down-regulation observed with vitamin D(3)/RA.	Vitamin D	92-101	coronin 1A	Homo sapiens	52-56
18241717-1	2008	OBJECTIVES: A 1-hour post-thyroidectomy parathyroid hormone (PTH) level of &lt; or =8 ng/L is predictive of patients who will develop hypocalcemia and guides early supplementation with calcium and vitamin D.	Vitamin D	197-206	parathyroid hormone	Homo sapiens	40-59
18191047-18	2008	Furthermore, serum 25(OH) D was positively correlated with insulin sensitivity, which was FM mediated, but negatively correlated with HbA(1c), implying that obese children and adolescents with low vitamin D status may be at increased risk of developing impaired glucose metabolism independent of body adiposity.	Vitamin D	197-206	insulin	Homo sapiens	59-66
18193490-4	2008	Recent data have shown that vitamin D acts as a negative regulator of the renin gene and that vitamin D deficiency is followed by increased renin-angiotensin II expression.	Vitamin D	28-37	renin	Homo sapiens	74-79
18175872-4	2008	It has been reported that direct vitamin D injection into parathyroid gland (PTG) efficiently decreased PTH level without significant changes of Ca level in dialysis patients as well as in uremic animals, possibly through up-regulation of CaSR and vitamin D receptor and decrease of cell number in PTC.	Vitamin D	33-42	calcium sensing receptor	Homo sapiens	239-243
18035050-3	2008	DBP possesses high affinity for vitamin D metabolites and G-actin, but ALB does not.	Vitamin D	32-41	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
18211694-12	2008	CONCLUSION: The presence and location of the vitamin D activating enzyme CYP27B1 as well as the specific receptor for vitamin D were shown in placental sections.	Vitamin D	45-54	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	73-80
18227004-1	2008	The working group PTH-Vitamin D of the SFBC recently underlined the great intertechnic variability of parathormone (PTH) assays.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	18-21
18227004-1	2008	The working group PTH-Vitamin D of the SFBC recently underlined the great intertechnic variability of parathormone (PTH) assays.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	116-119
18238737-14	2008	Early detection of elevated PTH levels with appropriate intervention using active vitamin D therapy, even in the absence of elevated serum phosphorus and reduced serum calcium, is critical.	Vitamin D	82-91	parathyroid hormone	Homo sapiens	28-31
18193490-4	2008	Recent data have shown that vitamin D acts as a negative regulator of the renin gene and that vitamin D deficiency is followed by increased renin-angiotensin II expression.	Vitamin D	94-103	renin	Homo sapiens	140-145
18078865-14	2008	These data denote that the accelerated linear growth after treatment of nutritional vitamin D deficiency is mediated through activation of the growth hormone/IGF-I system and suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and growth hormone/IGF-I secretion.	Vitamin D	84-93	growth hormone 1	Homo sapiens	143-157
18491455-4	2008	We evaluated the association between four Vitamin D Receptor polymorphisms (i.e. those identified by the restriction enzymes BsmI, ApaI, TaqI and FokI) and serum level of C-reactive protein in 88 hemodialysis patients routinely treated with active Vitamin D (calcitriol).	Vitamin D	42-51	C-reactive protein	Homo sapiens	171-189
18078865-14	2008	These data denote that the accelerated linear growth after treatment of nutritional vitamin D deficiency is mediated through activation of the growth hormone/IGF-I system and suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and growth hormone/IGF-I secretion.	Vitamin D	84-93	insulin like growth factor 1	Homo sapiens	158-163
18078865-14	2008	These data denote that the accelerated linear growth after treatment of nutritional vitamin D deficiency is mediated through activation of the growth hormone/IGF-I system and suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and growth hormone/IGF-I secretion.	Vitamin D	84-93	growth hormone 1	Homo sapiens	291-305
18078865-14	2008	These data denote that the accelerated linear growth after treatment of nutritional vitamin D deficiency is mediated through activation of the growth hormone/IGF-I system and suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and growth hormone/IGF-I secretion.	Vitamin D	84-93	insulin like growth factor 1	Homo sapiens	306-311
18816209-1	2008	BACKGROUND: A previous study using cinacalcet, as compared to vitamin D alone, showed a better reduction response of PTH levels and a significant diminution of secondary effects.	Vitamin D	62-71	parathyroid hormone	Homo sapiens	117-120
18087055-8	2007	Compared with placebo, established vitamin D sterols were associated with an increased risk for hypercalcemia (relative risk, 2.37 [95% CI, 1.16 to 4.85]) and hyperphosphatemia (relative risk, 1.77 [CI, 1.15 to 2.74]) but did not show a consistent reduction in parathyroid hormone (PTH) levels.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	261-280
18259100-8	2008	Only 50.8% of the patients had received vitamin D(3) metabolites prior to the start of the study and at baseline they had higher i-PTH levels (600.3 +/- 360.5 vs. 489.9 +/- 292.6, p = 0.02).	Vitamin D	40-49	parathyroid hormone	Homo sapiens	131-134
18278205-7	2008	In pts with vitamin D deficiency the sensitivity of a (99m)Tc-MIBI SPECT study was lower than in those with normal vitamin D status (72% vs. 91%) and dependent on the value for PTH.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	177-180
25983951-4	2008	However, doses of vitamin D sterols required to suppress parathyroid hormone (PTH) secretion often promote hypercalcaemia and hyperphosphataemia.	Vitamin D	18-27	parathyroid hormone	Homo sapiens	57-76
18087055-8	2007	Compared with placebo, established vitamin D sterols were associated with an increased risk for hypercalcemia (relative risk, 2.37 [95% CI, 1.16 to 4.85]) and hyperphosphatemia (relative risk, 1.77 [CI, 1.15 to 2.74]) but did not show a consistent reduction in parathyroid hormone (PTH) levels.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	282-285
18087055-10	2007	For suppression of PTH, intravenous administration was superior to oral vitamin D, but higher intravenous doses were used.	Vitamin D	72-81	parathyroid hormone	Homo sapiens	19-22
18029472-0	2007	High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice.	Vitamin D	13-22	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	65-72
17936069-5	2007	In fact Vitamin D showed an additive effect on alkaline phosphatase activity and calcium content, induced by FGF-2 and TGF-beta in human osteoblast.	Vitamin D	8-17	fibroblast growth factor 2	Homo sapiens	109-114
17936069-5	2007	In fact Vitamin D showed an additive effect on alkaline phosphatase activity and calcium content, induced by FGF-2 and TGF-beta in human osteoblast.	Vitamin D	8-17	transforming growth factor beta 1	Homo sapiens	119-127
18290716-1	2007	Tissue availability of the active vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] is dependent on expression of the activating enzyme 1alpha-hydroxylase (CYP27b1) and its catabolic counterpart 24-hydroxylase (CYP24).	Vitamin D	34-43	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	167-174
18290725-7	2007	The mechanisms that limit vitamin D safety are the capacity of circulating vitamin D-binding protein and the ability to suppress 25(OH)D-1-alpha-hydroxylase.	Vitamin D	26-35	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-156
18166692-7	2007	We examined IL-6 level as a function of vitamin D status using generalized estimating equations, adjusting for covariates.	Vitamin D	40-49	interleukin 6	Homo sapiens	12-16
18166692-8	2007	RESULTS: Women deficient in vitamin D at baseline had higher IL-6 levels in the year postfracture (p=.02).	Vitamin D	28-37	interleukin 6	Homo sapiens	61-65
18166692-10	2007	CONCLUSIONS: Women with vitamin D deficiency at the time of hip fracture had higher serum IL-6 levels in the year after hip fracture.	Vitamin D	24-33	interleukin 6	Homo sapiens	90-94
17471513-2	2007	Smad 3, a downstream component of transforming growth factor-beta (TGFbeta) signaling, has been shown to act as a coactivator of VDR and to possibly regulate the vitamin D signaling pathway.	Vitamin D	162-171	transforming growth factor beta 1	Homo sapiens	34-65
17471513-2	2007	Smad 3, a downstream component of transforming growth factor-beta (TGFbeta) signaling, has been shown to act as a coactivator of VDR and to possibly regulate the vitamin D signaling pathway.	Vitamin D	162-171	transforming growth factor beta 1	Homo sapiens	67-74
18029472-6	2007	High VD3 restored expression of vitamin D-regulated genes in intestine (calbindin D(9K)) and kidney (CYP27B1, 24-hydroxylase, calbindin D(9K)) of KO mice.	Vitamin D	32-41	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	101-108
17720197-1	2007	BACKGROUND: Parathyroid hormone (PTH) replacement has been demonstrated to be superior to conventional treatment with calcium supplementation and vitamin D analogs for the treatment of hypoparathyroidism.	Vitamin D	146-155	parathyroid hormone	Rattus norvegicus	12-31
17942777-3	2007	In normal animals and humans, factors such as phosphorus and vitamin D modify the basal parathyroid hormone level and the maximal parathyroid hormone response to hypocalcemia.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	88-107
18063090-2	2007	Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	34-37
18063090-12	2007	Vitamin D deficiency is associated with postoperative elevation of PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	67-70
17908281-3	2007	This study aimed to determine vitamin D status after renal transplantation and its effect on parathyroid hormone (PTH) and bone mineral density (BMD).	Vitamin D	30-39	parathyroid hormone	Homo sapiens	93-112
17656563-3	2007	The discussion will (1) highlight the basic elements of human immune response that is responsive to vitamin D, (2) recount work relevant to the extrarenal expression of the vitamin D-1-hydroxlase (CYP27b1) in the macrophage as an initiator of the innate immune response, and (3) describe recent work on the relevance of the vitamin D intracrine-autocrine-paracrine system in a model of a common and devastating human disease, tuberculosis.	Vitamin D	100-109	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	197-204
17656563-3	2007	The discussion will (1) highlight the basic elements of human immune response that is responsive to vitamin D, (2) recount work relevant to the extrarenal expression of the vitamin D-1-hydroxlase (CYP27b1) in the macrophage as an initiator of the innate immune response, and (3) describe recent work on the relevance of the vitamin D intracrine-autocrine-paracrine system in a model of a common and devastating human disease, tuberculosis.	Vitamin D	173-182	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	197-204
17942777-3	2007	In normal animals and humans, factors such as phosphorus and vitamin D modify the basal parathyroid hormone level and the maximal parathyroid hormone response to hypocalcemia.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	130-149
17942777-7	2007	In three causes of secondary hyperparathyroidism--chronic kidney disease, vitamin D deficiency, and aging--factors that affect the dynamics of parathyroid hormone secretion are evaluated in detail.	Vitamin D	74-83	parathyroid hormone	Homo sapiens	143-162
17942777-8	2007	During recovery from vitamin D deficiency, the maximal parathyroid hormone remains elevated while the basal parathyroid hormone value rapidly becomes normal because of a shift in the set point of calcium.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	55-74
17607662-1	2007	BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Homo sapiens	185-188
17942777-8	2007	During recovery from vitamin D deficiency, the maximal parathyroid hormone remains elevated while the basal parathyroid hormone value rapidly becomes normal because of a shift in the set point of calcium.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	108-127
17607662-1	2007	BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.	Vitamin D	16-25	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	194-201
17606874-0	2007	Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.	Vitamin D	19-28	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	45-52
17932346-0	2007	Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer.	Vitamin D	42-51	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	72-79
17449905-10	2007	Remarkably, in vivo treatment with the vitamin D analogue EB1089 induced DKK-1 protein expression in SW480-ADH cells xenografted in immunodeficient mice, and a correlation was observed in the expression of VDR and DKK-1 RNA in a series of 32 human colorectal tumours.	Vitamin D	39-48	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	73-78
17595320-0	2007	Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts.	Vitamin D	64-73	insulin like growth factor binding protein 5	Homo sapiens	0-44
17965521-4	2007	The ability of CYP3A4 mRNA induction in LS180 cells was highly dependent on the site and number of vitamin D(3) and D(2) hydroxylation.	Vitamin D	99-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	15-21
17914135-5	2007	RESULTS: Vitamin D stores were inversely related gain in bone area (p &lt; 0.002), BMC (p &lt; 0.002) BMD (p &lt; 0.027), as well as to PTH levels (p &lt; 0.0001).	Vitamin D	9-18	parathyroid hormone	Homo sapiens	136-139
17449905-10	2007	Remarkably, in vivo treatment with the vitamin D analogue EB1089 induced DKK-1 protein expression in SW480-ADH cells xenografted in immunodeficient mice, and a correlation was observed in the expression of VDR and DKK-1 RNA in a series of 32 human colorectal tumours.	Vitamin D	39-48	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	214-219
17488797-1	2007	CONTEXT: Vitamin D 1alpha-hydroxylase deficiency, also known as vitamin D-dependent rickets type 1, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia and is caused by mutations of the 25-hydroxyvitamin D 1alpha-hydroxylase (1alpha-hydroxylase, CYP27B1) gene.	Vitamin D	64-73	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	291-298
17656603-10	2007	A relationship between PTH, vitamin D, and insulin sensitivity based on the HOMA index was not found in obese children.	Vitamin D	28-37	insulin	Homo sapiens	43-50
17656603-11	2007	Further longitudinal clamp studies are necessary to study the relationship between vitamin D and insulin sensitivity.	Vitamin D	83-92	insulin	Homo sapiens	97-104
17342072-1	2007	BACKGROUND: Vitamin D-binding protein (DBP) gene is well known for its function on glucose and vitamin D metabolism in human populations.	Vitamin D	95-104	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
17660614-3	2007	Recognizing the patients with activating mutations in CaSR is quite important, because these patients can exhibit unusual sensitivity to treatment of their hypocalcemia with calcium and vitamin D supplementation, with toxic effects including nephrocalcinosis, renal stones, and diminished renal function.	Vitamin D	186-195	calcium sensing receptor	Homo sapiens	54-58
16797913-3	2007	The main influence on this physiological process of active absorption has Vitamin D, acting through Vitamin D receptors (VDR) located in the mucosal wall of the intestines, thus increasing Ca absorption.	Vitamin D	74-83	VDR	Ovis aries	100-119
16797913-3	2007	The main influence on this physiological process of active absorption has Vitamin D, acting through Vitamin D receptors (VDR) located in the mucosal wall of the intestines, thus increasing Ca absorption.	Vitamin D	74-83	VDR	Ovis aries	121-124
17463418-8	2007	Vitamin D supplementation significantly enhanced the ability of participants" whole blood to restrict BCG-lux luminescence in vitro compared with placebo (mean luminescence ratio at follow-up, 0.57, vs. 0.71, respectively; 95% confidence interval for difference, 0.01-0.25; p=0.03) but did not affect antigen-stimulated IFN-gamma secretion.	Vitamin D	0-9	interferon gamma	Homo sapiens	320-329
17657282-1	2007	BACKGROUND: In addition to the regulation of calcium homeostasis, vitamin D affects the cellular immune system, targets the TNF-alpha pathway and increases vasoconstrictor response to angiotensin II.	Vitamin D	66-75	tumor necrosis factor	Rattus norvegicus	124-133
17657282-1	2007	BACKGROUND: In addition to the regulation of calcium homeostasis, vitamin D affects the cellular immune system, targets the TNF-alpha pathway and increases vasoconstrictor response to angiotensin II.	Vitamin D	66-75	angiotensinogen	Rattus norvegicus	184-198
17547711-2	2007	Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels.	Vitamin D	16-25	parathyroid hormone	Homo sapiens	79-98
17878529-2	2007	This tissue-specific expression of 1alpha-OHase may act as the pivotal link between vitamin D status (25(OH)D3 levels) and the anticancer effects of 1,25(OH)2 D3.	Vitamin D	84-93	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	35-47
17823618-8	2007	Although prolactin"s effects on calcium absorption are not directly vitamin D-dependent; a certain level of circulating vitamin D may be required for the basal expression of genes related to calcium transport.	Vitamin D	120-129	prolactin	Rattus norvegicus	9-18
17513768-0	2007	IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37.	Vitamin D	31-40	interferon gamma	Homo sapiens	0-18
17699936-1	2007	Vitamin D as a part of the endocrine system is an important component in the interaction between the kidney, bone, parathyroid hormone, and the intestine, which maintains extracellular calcium level within normal limits, in order to keep the vital physiologic process and skeletal integrity.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	115-134
17500032-0	2007	Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene.	Vitamin D	31-40	arachidonate 5-lipoxygenase	Homo sapiens	73-87
17395703-1	2007	The cytochrome P450 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27b1) plays a pivotal role in vitamin D physiology by catalyzing synthesis of active 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	30-39	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	61-68
17473068-9	2007	Vitamin D supplementation of both the proband and the baby resulted in reduction of serum PTH levels to the normal range.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	90-93
17473068-12	2007	Concomitant vitamin D deficiency modulates the severity of the presentation of FHH.	Vitamin D	12-21	calcium sensing receptor	Homo sapiens	79-82
17351276-1	2007	OBJECTIVE: Accumulating research suggests low-circulating vitamin D concentrations, i.e., 25-hydroxyvitamin-D [25(OH)D], may be associated with an increased prevalence of metabolic syndrome; however, previous studies have not accounted for parathyroid hormone (PTH) levels.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	240-259
17487428-4	2007	Here we present data demonstrating that the active metabolite of vitamin D, 1alpha,25-dihydroxy-vitamin D3, is a PARP inhibitor.	Vitamin D	65-74	poly(ADP-ribose) polymerase 1	Homo sapiens	113-117
17487428-5	2007	UV irradiation-mediated PARP activation in human keratinocytes can be inhibited by treatment with vitamin D, 7-dehydrocholesterol or 1alpha,25-dihydroxyvitamin D3.	Vitamin D	98-107	poly(ADP-ribose) polymerase 1	Homo sapiens	24-28
17487428-6	2007	Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1alpha,25-dihydroxyvitamin D3 mediates their PARP inhibitory action.	Vitamin D	69-78	poly(ADP-ribose) polymerase 1	Homo sapiens	43-47
17487428-6	2007	Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1alpha,25-dihydroxyvitamin D3 mediates their PARP inhibitory action.	Vitamin D	69-78	poly(ADP-ribose) polymerase 1	Homo sapiens	180-184
17487428-7	2007	Vitamin D may protect keratinocytes against over-activation of PARP resulting from exposure to sunlight.	Vitamin D	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	63-67
17487428-8	2007	PARP inhibition may contribute to the pharmacological and anti-inflammatory effects of vitamin D.	Vitamin D	87-96	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
17605511-11	2007	Medical management of the PTH/vitamin D/calcium and phosphorus imbalances in SHPT focus on regulating PTH levels via vitamin D therapy.	Vitamin D	30-39	parathyroid hormone	Homo sapiens	102-105
17605511-11	2007	Medical management of the PTH/vitamin D/calcium and phosphorus imbalances in SHPT focus on regulating PTH levels via vitamin D therapy.	Vitamin D	117-126	parathyroid hormone	Homo sapiens	26-29
17605511-11	2007	Medical management of the PTH/vitamin D/calcium and phosphorus imbalances in SHPT focus on regulating PTH levels via vitamin D therapy.	Vitamin D	117-126	parathyroid hormone	Homo sapiens	102-105
17547711-2	2007	Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels.	Vitamin D	16-25	parathyroid hormone	Homo sapiens	100-103
21938222-8	2007	Prevalence of vitamin D deficiency is higher (47%) in those whose workday day started earlier than in those whose workday started later (12%).In the second phase of the survey, 58 executives with low B12/ D3 values, were given vitamin B12/D3 oral supplements for a period of three months along with counseling for lifestyle modification.	Vitamin D	14-23	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	200-203
17595934-11	2007	Our data implies that enhancing vitamin-D nutrition resulting in lower serum PTH levels could potentially influence their peak bone mass.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	77-80
17277339-11	2007	CONCLUSIONS: In summary, the combination of cinacalcet and low doses of vitamin D improved significantly the control of PTH and Ca x P in patients with severe secondary hyperparathyroidism on chronic haemodialysis, without adverse effects and with lower doses of phosphate binders.	Vitamin D	72-81	parathyroid hormone	Homo sapiens	120-123
17471000-5	2007	Although the effects of vitamin D such as down-regulation of renin-angiotensin system, anti-proliferation, pro-differentiation, and immunomodulation have been reported, the mechanism of the renoprotective function remains unclear.	Vitamin D	24-33	renin	Homo sapiens	61-66
17471001-1	2007	It is well known that vitamin D deficiency and associated elevation of parathyroid hormone (PTH) are common in general population.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	71-90
17471001-5	2007	Given that vitamin D is associated with renin-angiotensin-aldosterone system and insulin resistance, intervention on vitamin D metabolism in CKD patients may have impact on clinical outcomes besides bone metabolism.	Vitamin D	11-20	renin	Homo sapiens	40-45
17433303-2	2007	We show that VitD(3) increases PLD1 gene expression through a vitamin D responsive element (VDRE) on the 5" PLD1 promoter (-260 bp to -246 bp from exon 1).	Vitamin D	62-71	phospholipase D1	Homo sapiens	31-35
17433303-2	2007	We show that VitD(3) increases PLD1 gene expression through a vitamin D responsive element (VDRE) on the 5" PLD1 promoter (-260 bp to -246 bp from exon 1).	Vitamin D	62-71	phospholipase D1	Homo sapiens	108-112
17372031-2	2007	Laboratory studies indicate that 1,25-dihydroxyvitamin D suppresses renin expression and vascular smooth muscle cell proliferation; clinical studies demonstrate an inverse association between ultraviolet radiation, a surrogate marker for vitamin D synthesis, and blood pressure.	Vitamin D	47-56	renin	Homo sapiens	68-73
17408240-2	2007	The vitamin D-induced protein-protein interactions between VDR and fluorophore (Cy3 or Cy5)-labeled TIF2 or SRC-1 were successfully detected by using a new HCHO fixing method of the protein complex on microplates.	Vitamin D	4-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-113
17397830-4	2007	The reactivation of NF-kappaB was concomitant with increased IKK activities, IKK-mediated IkappaBalpha phosphorylation, p65 phosphorylation at residues S276 and S536, p65 nuclear translocation and p65 recruitment to the NF-kappaB/vitamin D responsive element promoters.	Vitamin D	230-239	nuclear factor kappa B subunit 1	Homo sapiens	20-29
17122955-0	2007	Calcium-PTH-vitamin D axis in older patients with hip fracture.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	8-11
17431122-7	2007	Because HIF-1 is a major positive contributor in human tumorigenesis and angiogenesis, we believe that its inhibition by 1,25(OH)(2)D(3) strengthens the rationale to use vitamin D and its low-calcemic analogues in cancer chemoprevention and therapy.	Vitamin D	170-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-13
17302875-2	2007	We have suggested that non-1alpha-hydroxylated (nonactive) vitamin D analogues may present an alternative in tumour cells expressing 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-hydroxylase).	Vitamin D	59-68	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	133-174
17397543-1	2007	BACKGROUND: The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit development of inflammatory bowel disease (IBD) in IL-10 KO mice.	Vitamin D	31-40	interleukin 10	Mus musculus	132-137
17302875-4	2007	PATIENTS AND METHODS: Effects of vitamin D analogues and ketoconazole on parathyroid hormone (PTH) secretion (radioimmunoassay) and PTH mRNA expression (reverse transcription-polymerase chain reaction) were studied in primary bovine parathyroid cells.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	73-92
17339744-2	2007	In developing these guidelines, the K/DOQI apparently considered the recently established fact that control of Ca, P and PTH influences not only the development of bone lesions but also patient prognostic factors such as arteriosclerosis, ectopic calcification, and cardiovascular complications, as well as the development of various vitamin D products and analogues and new P adsorbents.	Vitamin D	334-343	parathyroid hormone	Homo sapiens	121-124
17290304-0	2007	Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.	Vitamin D	77-86	toll like receptor 2	Homo sapiens	16-20
17267205-1	2007	In a previous study we demonstrated a down-regulatory effect of vitamin D active metabolite (1,25(OH)(2)D(3)) and its vitamin D(2) analog (1,24(OH)(2)D(2)) on TNFalpha expression in macrophages.	Vitamin D	64-73	tumor necrosis factor	Mus musculus	159-167
17207995-4	2007	Active Vitamin D elicits its renal protective activity through multiple mechanisms, such as inhibiting renal inflammation, regulating renin-angiotensin system and blocking mesangial cell activation.	Vitamin D	7-16	renin	Homo sapiens	134-139
17218095-1	2007	Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D interacting complex)/Mediator complex.	Vitamin D	31-40	MYB binding protein 1a	Homo sapiens	221-225
17218095-1	2007	Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D interacting complex)/Mediator complex.	Vitamin D	31-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	226-229
17236759-9	2007	In conclusion, the modulation of the 1alpha-OHase opens up a new target for vitamin D(3) related therapies in endometrial cancer.	Vitamin D	76-85	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	37-49
17267205-1	2007	In a previous study we demonstrated a down-regulatory effect of vitamin D active metabolite (1,25(OH)(2)D(3)) and its vitamin D(2) analog (1,24(OH)(2)D(2)) on TNFalpha expression in macrophages.	Vitamin D	118-127	tumor necrosis factor	Mus musculus	159-167
17368185-9	2007	Combining these agents with higher doses of vitamin D compounds may achieve greater suppression of PTH and possibly enhance survival in patients with chronic kidney disease.	Vitamin D	44-53	parathyroid hormone	Homo sapiens	99-102
17368185-5	2007	Vitamin D analogs that inhibit PTH gene transcription and parathyroid hyperplasia, and that have less calcemic activity than 1alpha,25(OH)(2)D(3,) have provided a greater safety margin for the treatment of 2 degrees HPT, as well as enhancing the survival of CKD patients.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	31-34
17223545-4	2007	In the studies reported here, we utilized the above techniques to identify key enhancer regions that mediate the actions of vitamin D on the calcium ion channel gene TRPV6, the catabolic bone calcium-mobilizing factor gene RankL and the bone anabolic Wnt signaling pathway co-receptor gene LRP5.	Vitamin D	124-133	LDL receptor related protein 5	Homo sapiens	290-294
17118558-7	2007	Similarly, mRNA levels of vitamin D target genes ecac1, cabp-d28k and ncx-1, involved in renal calcium transport were decreased in kidney.	Vitamin D	26-35	solute carrier family 8 member A1	Rattus norvegicus	70-75
17347552-4	2007	Vitamin D-binding protein (DBP) binds, transports and activates vitamin D, which plays a major role in calcium homeostasis and bone turnover.	Vitamin D	64-73	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
17095575-2	2007	We have previously reported a novel class of negative vitamin D response element (nVDRE) called 1alphanVDRE in the human 25(OH)D31alpha-hydroxylase [1alpha(OH)ase] gene by 1alpha,25(OH)2D3-bound VDR.	Vitamin D	54-63	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	149-162
17250953-1	2007	CYP27B1 is a critical enzyme of Vitamin D biosynthesis that hydroxylates 25(OH)D(3) at the final step of the biosynthetic pathway.	Vitamin D	32-41	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
17443033-1	2007	BACKGROUND: In hemodialysis patients, adynamic bone disease has been reported to be closely associated with low levels of parathyroid hormone (PTH) due to exposure to high levels of serum calcium following the administration of calcium carbonate (CaCO3) or vitamin D agents.	Vitamin D	257-266	parathyroid hormone	Homo sapiens	122-141
17244528-4	2007	Various Ca(2+) mobilizing agents (vitamin D(3) compounds, ionomycin, ATP, and thapsigargin) inhibit the activity of mammalian target of rapamycin, a negative regulator of macroautophagy, and induce massive accumulation of autophagosomes in a Beclin 1- and Atg7-dependent manner.	Vitamin D	34-43	mechanistic target of rapamycin kinase	Homo sapiens	116-145
17029768-3	2007	We therefore investigated basal and Vitamin D-regulated expression and activity of the synthesizing (CYP27B1) and metabolizing (CYP24A1) hydroxylase in three cell lines derived from the colon, and compared this to cells from the prostate and mammary gland.	Vitamin D	36-45	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	101-108
17215573-0	2007	Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid hormone concentrations in chronic kidney disease.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	68-87
17899431-4	2007	A number of therapies aimed at reducing PTH concentration are associated with an increase of calcaemia and Ca x P product, e.g. calcium-containing phosphate binders or active vitamin D.	Vitamin D	175-184	parathyroid hormone	Homo sapiens	40-43
17237840-5	2007	Vitamin D analogs that inhibit PTH gene transcription and parathyroid hyperplasia (and have reduced calcemic activity) are a safer treatment for secondary hyperparathyroidism than calcitriol; these agents enhance the survival of patients with CKD.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	31-34
17237840-8	2007	The risk of hypercalcemia with vitamin D analog therapy is reduced by the introduction of non-calcium-based phosphate binders and cinacalcet; furthermore, recent trials indicate that early intervention with vitamin D analogs in stage 3 and 4 CKD can correct PTH levels, and could prevent renal bone disease and prolong patient survival.	Vitamin D	31-40	parathyroid hormone	Homo sapiens	258-261
17237840-8	2007	The risk of hypercalcemia with vitamin D analog therapy is reduced by the introduction of non-calcium-based phosphate binders and cinacalcet; furthermore, recent trials indicate that early intervention with vitamin D analogs in stage 3 and 4 CKD can correct PTH levels, and could prevent renal bone disease and prolong patient survival.	Vitamin D	207-216	parathyroid hormone	Homo sapiens	258-261
17456022-7	2007	While ERp57/GR58/1,25D3-MARRS receptor is a pivotal protein in many cell functions, it has yet to be determined whether-and to what extent-these phenomena are regulated by the vitamin D endocrine system.	Vitamin D	176-185	protein disulfide isomerase family A member 3	Homo sapiens	6-11
17536208-1	2007	BACKGROUND: Previous studies have shown that serum albumin or vitamin D is associated with physical performance.	Vitamin D	62-71	albumin	Homo sapiens	51-58
17046242-8	2007	These results suggest that the differential effect of Vitamin D analogs on stimulating intestinal and Caco-2 calcium transport may be in part due to its different effect on stimulating CALB3 and TRPV6 mRNA expression.	Vitamin D	54-63	S100 calcium binding protein G	Homo sapiens	185-190
17049230-0	2007	The Vitamin D analogue TX 527 blocks NF-kappaB activation in peripheral blood mononuclear cells of patients with Crohn"s disease.	Vitamin D	4-13	nuclear factor kappa B subunit 1	Homo sapiens	37-46
17079137-1	2007	Human placenta synthesizes and metabolizes 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)/calcitriol] through the activity of 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1) and 1,25(OH)(2)D(3)-24-hydroxylase (CYP24A1), the two key enzymes for Vitamin D metabolism.	Vitamin D	245-254	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	123-164
17890873-2	2007	BACKGROUND: Disturbances in mineral and vitamin D metabolism, which affect parathyroid hormone (PTH) synthesis, are well recognized in patients receiving dialysis.	Vitamin D	40-49	parathyroid hormone	Homo sapiens	75-94
17159355-0	2007	Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells.	Vitamin D	0-9	thrombospondin 1	Homo sapiens	80-96
17213855-2	2007	They demonstrate that these patients do not show vitamin D deficiency unless renal function is severely affected (GFR&lt;29 mL/min/1.73m2), while vitamin D and renal function loss are independently associated with insulin resistance.	Vitamin D	146-155	insulin	Homo sapiens	214-221
17426122-0	2007	Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene.	Vitamin D	26-35	iodothyronine deiodinase 3	Homo sapiens	96-98
17426122-0	2007	Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene.	Vitamin D	26-35	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	141-148
17426122-3	2007	The down-regulation of the CYP27B1 gene has been proposed to involve a negative vitamin D response element (nVDRE) that is located approximately 500 bp upstream from transcription start site (TSS).	Vitamin D	80-89	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	27-34
17168675-11	2006	Genomic expression profile with vitamin D indicated differential expression of gene targets such as c-JUN, JUNB, JUND, FREAC-1/FoxF1, ZNF-44/KOX7, plectin, filamin, and keratin-13, involved in antiproliferative, differentiation pathways.	Vitamin D	32-41	keratin, type I cytoskeletal 13	Sus scrofa	169-179
17003089-1	2006	CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas.	Vitamin D	13-22	parathyroid hormone	Homo sapiens	256-259
21432355-5	2006	In young adults, a high intact PTH concentration due to vitamin D insufficiency, which adversely affects their bone mass, is common, suggesting that vitamin D nutrition, as well as dietary calcium intake, should be improved.	Vitamin D	56-65	parathyroid hormone	Homo sapiens	31-34
17199880-12	2006	When the concentration of serum intact parathyroid hormone (PTH) was more than 200 pg/mL, the frequency of use of an orally administered vitamin D preparation decreased; but that of intravenous vitamin D preparation increased.	Vitamin D	137-146	parathyroid hormone	Homo sapiens	39-58
17199880-12	2006	When the concentration of serum intact parathyroid hormone (PTH) was more than 200 pg/mL, the frequency of use of an orally administered vitamin D preparation decreased; but that of intravenous vitamin D preparation increased.	Vitamin D	194-203	parathyroid hormone	Homo sapiens	39-58
16732322-6	2006	Most importantly, we have identified a vitamin D responsive element (VDRE) in the promoter region of the human KSR-1 gene, to which VDR binds in a 1,25D-dependent manner, in vitro and in vivo.	Vitamin D	39-48	kinase suppressor of ras 1	Homo sapiens	111-116
21432355-5	2006	In young adults, a high intact PTH concentration due to vitamin D insufficiency, which adversely affects their bone mass, is common, suggesting that vitamin D nutrition, as well as dietary calcium intake, should be improved.	Vitamin D	149-158	parathyroid hormone	Homo sapiens	31-34
17056528-6	2006	We report that vitamin D(3) and 1,25-(OH)(2)D(3) strongly inhibited myelin oligodendrocyte peptide (MOG(35-55))-induced EAE in C57BL/6 mice, but completely failed to inhibit EAE in mice with a disrupted IL-10 or IL-10R gene.	Vitamin D	15-24	interleukin 10	Mus musculus	203-208
16828339-3	2006	Apart from its adverse effects on bone in women and their offspring, vitamin D deficiency has the potential to cause or exacerbate heart failure through a number of mechanisms including activation of the renin-angiotensin system and increased arterial pressure.	Vitamin D	69-78	renin	Homo sapiens	204-209
17056528-11	2006	In this way, a genetic IL-10-IL-10R pathway defect could interact with an environmental risk factor, vitamin D(3) insufficiency, to increase MS risk and severity.	Vitamin D	101-110	interleukin 10	Mus musculus	23-28
17056796-1	2006	The major circulating form of vitamin D is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP).	Vitamin D	30-39	D-box binding PAR bZIP transcription factor	Homo sapiens	171-174
16960175-1	2006	BACKGROUND: Optimal vitamin D status for the prevention of osteoporosis has been inferred from examinations of the serum 25-hydroxyvitamin D [25(OH)D] concentration below which there is an increase in serum parathyroid hormone (PTH).	Vitamin D	20-29	parathyroid hormone	Homo sapiens	207-226
16697362-1	2006	The vitamin D binding protein (DBP) is the major plasma carrier protein of vitamin D and its metabolites.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
16362385-6	2006	We thus conclude that ER and VDR genes may contribute to lumbar spondylosis in a distinct manner: estrogen sensitivity influences the severity in the early phase after menopause while vitamin D plays an important role at older ages when the contribution of estrogen loss is weaker.	Vitamin D	184-193	estrogen receptor 1	Homo sapiens	22-24
17040494-1	2006	Vitamin D(3) upregulated protein 1 (VDUP1) is a 46-kDa multifunctional protein, initially isolated in HL-60 cells as a protein of which expression is upregulated by vitamin D(3) administration.	Vitamin D	165-174	thioredoxin interacting protein	Homo sapiens	0-34
17040494-1	2006	Vitamin D(3) upregulated protein 1 (VDUP1) is a 46-kDa multifunctional protein, initially isolated in HL-60 cells as a protein of which expression is upregulated by vitamin D(3) administration.	Vitamin D	165-174	thioredoxin interacting protein	Homo sapiens	36-41
17216021-5	2006	An interaction was suggested between Vitamin D metabolism and inflammation indexes through mediation of TNF-alpha which is also especially involved in osteoclastic resorption and therefore in bone loss processes.	Vitamin D	37-46	tumor necrosis factor	Homo sapiens	104-113
17020998-0	2006	Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1;Pten mutant mice.	Vitamin D	0-9	phosphatase and tensin homolog	Mus musculus	82-86
16571643-0	2006	Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1.	Vitamin D	0-9	neurofibromin 1	Homo sapiens	64-83
16571643-5	2006	The serum vitamin D concentration and number of dermal neurofibromas reported by patients with NF1 were inversely correlated (Spearman"s rho = -0.572, p<0.00001).	Vitamin D	10-19	neurofibromin 1	Homo sapiens	95-98
16571643-6	2006	The occurrence of low serum vitamin D concentrations in people with NF1, especially those with many dermal neurofibromas, may provide new pathogenic insights and have important therapeutic implications.	Vitamin D	28-37	neurofibromin 1	Homo sapiens	68-71
17142213-0	2006	Effects of ACE gene polymorphism on vitamin D therapy according to parathyroid hormone level in patients on hemodialysis.	Vitamin D	36-45	angiotensin I converting enzyme	Homo sapiens	11-14
17142213-3	2006	The aim of this study was to evaluate the association of genetic influences of angiotensinconverting enzyme (ACE) gene polymorphisms with response to vitamin D therapy among patients on hemodialysis (HD).	Vitamin D	150-159	angiotensin I converting enzyme	Homo sapiens	79-107
17142213-3	2006	The aim of this study was to evaluate the association of genetic influences of angiotensinconverting enzyme (ACE) gene polymorphisms with response to vitamin D therapy among patients on hemodialysis (HD).	Vitamin D	150-159	angiotensin I converting enzyme	Homo sapiens	109-112
16741990-0	2006	Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth.	Vitamin D	74-83	tumor protein p53	Homo sapiens	90-93
17142213-7	2006	Patients with the DD allele (group DD) of ACE gene polymorphism had (1) significantly elevated mean 5-y intact parathyroid hormone levels when compared with the non-DD group (P=.009), and (2) significantly elevated oral and intravenous 5-y cumulative doses of vitamin D.	Vitamin D	260-269	angiotensin I converting enzyme	Homo sapiens	42-45
16598763-8	2006	In conclusion, preconfluent CaCo-2 cells and THP-1 macrophages are able to induce vitamin D activity upon UVB irradiation and hence combine all parts of the vitamin D photoendocrine system, a characteristic which is therefore not keratinocyte specific.	Vitamin D	82-91	GLI family zinc finger 2	Homo sapiens	45-50
16598763-8	2006	In conclusion, preconfluent CaCo-2 cells and THP-1 macrophages are able to induce vitamin D activity upon UVB irradiation and hence combine all parts of the vitamin D photoendocrine system, a characteristic which is therefore not keratinocyte specific.	Vitamin D	157-166	GLI family zinc finger 2	Homo sapiens	45-50
16918598-6	2006	An overexpression of p18 in 1,25(OH)(2)Vitamin D(3) vs. ethanol-treated cells was determined until 30 h in SCC25.	Vitamin D	39-48	cyclin dependent kinase inhibitor 2C	Homo sapiens	21-24
16918598-8	2006	CONCLUSION: One mechanism by which 1,25(OH)(2)Vitamin D(3) controls cell growth might be the upregulation of p21.	Vitamin D	46-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	109-112
16918598-1	2006	BACKGROUND: 1Alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2) Vitamin D(3)] induces growth inhibition in squamous cell carcinoma (SCC) cell lines of the head and neck by arresting the cells in the G0/G1 phase of the cell cycle, probably due to an enhanced expression of p21, which could be demonstrated in other cell lines (JPPA, SCC9) before.	Vitamin D	57-66	cyclin dependent kinase inhibitor 1A	Homo sapiens	265-268
16918598-10	2006	The proven upregulation of p18 seems to be the responsible step for growth inhibition of 1,25(OH)(2)Vitamin D(3) in SCC25.	Vitamin D	100-109	cyclin dependent kinase inhibitor 2C	Homo sapiens	27-30
16713028-7	2006	We have proposed that PTH reference values should be established in healthy subjects with a normal vitamin D status.	Vitamin D	99-108	parathyroid hormone	Homo sapiens	22-25
16644777-1	2006	BACKGROUND: Recent guidelines suggest supplementation with ergocalciferol (vitamin D(2)) in chronic kidney disease stages 3 and 4 patients with elevated parathyroid hormone (PTH) levels and 25-hydroxyvitamin D (25OHD) levels &lt;75 nmol/l.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	153-172
16644777-1	2006	BACKGROUND: Recent guidelines suggest supplementation with ergocalciferol (vitamin D(2)) in chronic kidney disease stages 3 and 4 patients with elevated parathyroid hormone (PTH) levels and 25-hydroxyvitamin D (25OHD) levels &lt;75 nmol/l.	Vitamin D	75-84	parathyroid hormone	Homo sapiens	174-177
16613987-2	2006	Some of these effects of vitamin D are reminiscent of those orchestrated by the Wnt signaling pathway wherein stimulation of the membrane receptor Frizzled and its coreceptor LRP5 leads to activation of beta-catenin and subsequent transcription-mediated changes in osteoblast biology.	Vitamin D	25-34	LDL receptor related protein 5	Homo sapiens	175-179
16613987-7	2006	One of these sites within the Lrp5 locus was discovered to confer vitamin D response to a heterologous promoter when introduced into osteoblastic cells, permitting both the identification and characterization of the vitamin D response element located within.	Vitamin D	66-75	LDL receptor related protein 5	Homo sapiens	30-34
16613987-7	2006	One of these sites within the Lrp5 locus was discovered to confer vitamin D response to a heterologous promoter when introduced into osteoblastic cells, permitting both the identification and characterization of the vitamin D response element located within.	Vitamin D	216-225	LDL receptor related protein 5	Homo sapiens	30-34
16563471-13	2006	Vitamin D supplementation to vitamin D-deficient elderly suppresses serum PTH, increases bone mineral density and may decrease fracture incidence especially in nursing home residents.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	74-77
16563471-13	2006	Vitamin D supplementation to vitamin D-deficient elderly suppresses serum PTH, increases bone mineral density and may decrease fracture incidence especially in nursing home residents.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	74-77
17117291-7	2006	Serum PTH and bone markers are considerable higher in severely affected patients, who also have a high rate of vitamin D deficiency, and the parathyroid lesion is easier located compared with asymptomatic patients.	Vitamin D	111-120	parathyroid hormone	Homo sapiens	6-9
17117292-1	2006	The principal function of the parathyroid hormone (PTH) is maintenance of calcium plasmatic levels, withdrawing the calcium from bone tissue, reabsorbing it from the glomerular filtrate, and indirectly increasing its intestinal absorption by stimulating active vitamin D (calcitriol) production.	Vitamin D	261-270	parathyroid hormone	Homo sapiens	30-49
17117292-1	2006	The principal function of the parathyroid hormone (PTH) is maintenance of calcium plasmatic levels, withdrawing the calcium from bone tissue, reabsorbing it from the glomerular filtrate, and indirectly increasing its intestinal absorption by stimulating active vitamin D (calcitriol) production.	Vitamin D	261-270	parathyroid hormone	Homo sapiens	51-54
16956425-8	2006	Vitamin D stimulated the expression of cox-2 mRNA which was further enhanced by TNF-alpha/IL-1beta.	Vitamin D	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16868136-13	2006	CONCLUSION: In this material, low levels of 25OHD were related to higher levels of P-PTH and higher PTH:AW ratios in patients with PHPT suggesting that vitamin D deficiency increase PTH secretion activity.	Vitamin D	152-161	parathyroid hormone	Homo sapiens	100-103
16807549-1	2006	Active vitamin D compounds repress parathyroid hormone (PTH) gene transcription and block chief cell hyperplasia, making them integral tools in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	56-59
16816469-5	2006	Experimentally, active vitamin D inhibits atherogenic cellular behaviors and activation of the renin-angiotensin system.	Vitamin D	23-32	renin	Homo sapiens	95-100
16816472-1	2006	CYP27A1, CYP27B1, and CYP24A1 are members of the cytochrome P450 superfamily, and key enzymes of vitamin D(3) metabolism.	Vitamin D	97-106	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	9-16
16816472-8	2006	Surprisingly, more than 70% of the vitamin D metabolites observed in a living body were found to be the products formed by the activities of CYP27A1, CYP27B1, and CYP24A1.	Vitamin D	35-44	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	150-157
16911633-2	2006	AIMS: The aim of this study was to investigate whether supplementation with the active form of vitamin D (calcitriol) in subjects with recent-onset T1D protects residual pancreatic beta-cell function and improves glycaemic control (HbA(1c) and insulin requirement).	Vitamin D	95-104	insulin	Homo sapiens	244-251
16884395-11	2006	Assay type, patient characteristics (race, underlying renal disease) and treatment attributes (vitamin D, corticosteroids, phosphate binders) have an impact on the PTH ratio, and care should be used in interpreting assay results and making subsequent treatment decisions.	Vitamin D	95-104	parathyroid hormone	Homo sapiens	164-167
16737686-5	2006	Moreover, while the Gemini Vitamin D(3) analog Ro3582 modulated the expression of several Vitamin D target genes such as the 24-hydroxylase, CD14, osteocalcin, and osteopontin in both cell lines, Ro3582 regulated many genes involved in cell proliferation and apoptosis, cell adhesion, invasion, angiogenesis as well as cell signaling pathways, such as the BMP and TGF-beta systems, differently in the two cell lines.	Vitamin D	27-36	bone gamma-carboxyglutamate protein	Homo sapiens	147-158
16737686-5	2006	Moreover, while the Gemini Vitamin D(3) analog Ro3582 modulated the expression of several Vitamin D target genes such as the 24-hydroxylase, CD14, osteocalcin, and osteopontin in both cell lines, Ro3582 regulated many genes involved in cell proliferation and apoptosis, cell adhesion, invasion, angiogenesis as well as cell signaling pathways, such as the BMP and TGF-beta systems, differently in the two cell lines.	Vitamin D	90-99	bone gamma-carboxyglutamate protein	Homo sapiens	147-158
16886668-1	2006	Like most pharmaceutical agents, vitamin D analogs are subject to hepatic metabolism by a variety of cytochrome P450 (CYP)-based systems.	Vitamin D	33-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-116
16886668-1	2006	Like most pharmaceutical agents, vitamin D analogs are subject to hepatic metabolism by a variety of cytochrome P450 (CYP)-based systems.	Vitamin D	33-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-121
16886676-1	2006	BACKGROUND: Levels of active vitamin D (VD) are controlled by synthesis via CYP27B1 and self-induced metabolism by CYP24A1.	Vitamin D	29-38	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	76-83
16956425-8	2006	Vitamin D stimulated the expression of cox-2 mRNA which was further enhanced by TNF-alpha/IL-1beta.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	80-89
16956425-8	2006	Vitamin D stimulated the expression of cox-2 mRNA which was further enhanced by TNF-alpha/IL-1beta.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	90-98
16714211-2	2006	AIM: The aim of this study was to investigate whether KH 1060, a vitamin D analogue, could decrease tumor necrosis factor-alpha (TNF-alpha) levels in patients with inflammatory bowel disease (IBD).	Vitamin D	65-74	tumor necrosis factor	Homo sapiens	100-127
16901796-6	2006	These abnormalities were likely due to vitamin D deficiency, evidenced by a 25-hydroxyvitamin D level of 14 ng/mL, which provoked an elevation of the serum parathyroid hormone (PTH) concentration, documented by an intact PTH of 213 pg/mL (normal, 15 to 65) and a whole PTH (1-84 PTH) of 70.6 pg/mL (normal, 7 to 36).	Vitamin D	39-48	parathyroid hormone	Homo sapiens	156-175
16714211-2	2006	AIM: The aim of this study was to investigate whether KH 1060, a vitamin D analogue, could decrease tumor necrosis factor-alpha (TNF-alpha) levels in patients with inflammatory bowel disease (IBD).	Vitamin D	65-74	tumor necrosis factor	Homo sapiens	129-138
16603771-1	2006	The WSTF (Williams syndrome transcription factor) protein is involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively.	Vitamin D	73-82	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	4-8
17142943-1	2006	OBJECTIVE: To assess the effect of smoking and smoking cessation on bone density, bone remodeling markers, sex hormones, and vitamin D-PTH axis in healthy young subjects.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	135-138
17142943-7	2006	CONCLUSIONS: Tobacco increases bone resorption and affects bone mass by some alterations in sex hormone metabolism, but also importantly by alterations on the vitamin D-PTH axis.	Vitamin D	159-168	parathyroid hormone	Homo sapiens	169-172
16846786-1	2006	Osteoblast maturation is partly controlled by the interaction of 1alpha,25(OH)(2)D(3) (D3), an active metabolite of Vitamin D, with other growth factors.	Vitamin D	116-125	iodothyronine deiodinase 3	Homo sapiens	87-89
16603771-1	2006	The WSTF (Williams syndrome transcription factor) protein is involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively.	Vitamin D	73-82	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	10-48
16868893-0	2006	Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves" disease and the vitamin D status in a Polish population study.	Vitamin D	93-102	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
16425262-0	2006	Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer.	Vitamin D	21-30	androgen receptor	Homo sapiens	64-81
16425262-2	2006	We evaluate how the number of polyglutamine (CAG) repeats of the AR gene influence colorectal cancer in conjunction with vitamin D, sunshine exposure and VDR.	Vitamin D	121-130	androgen receptor	Homo sapiens	65-67
16425262-4	2006	Vitamin D intake and average hours of sunshine exposure interacted with AR genotype in men.	Vitamin D	0-9	androgen receptor	Homo sapiens	72-74
16425262-5	2006	Men with low vitamin D intake or low levels of sunshine exposure who had 23+ CAG repeats of the AR gene had the greatest risk of colon cancer.	Vitamin D	13-22	androgen receptor	Homo sapiens	96-98
16425262-6	2006	ORs for men with 23 or more CAG repeats of the AR gene and in the lowest tertile of vitamin D intake or sunshine exposure were 1.71 (95% CI 1.14, 2.56) and 1.51 (95% CI 1.09, 2.09).	Vitamin D	84-93	androgen receptor	Homo sapiens	47-49
16464653-9	2006	TM and TI patients with low 25-OH-vitamin D levels (&lt;17.8 ng/ml) presented higher serum ferritin levels (P &lt; 0.01) and higher PTH (P &lt; 0.05) compared to those with normal vitamin D.	Vitamin D	34-43	parathyroid hormone	Homo sapiens	132-135
16751687-5	2006	PTH also acts on renal tubule to promote urinary excretion of phosphate as well as production active vitamin D (1,25 [OH] 2D) .	Vitamin D	101-110	parathyroid hormone	Homo sapiens	0-3
16425262-9	2006	These data provide support for the role of vitamin D and sunshine exposure in the etiology of colorectal cancer and suggest that AR gene may modulate the association.	Vitamin D	43-52	androgen receptor	Homo sapiens	129-131
16868893-1	2006	OBJECTIVE: Vitamin D-binding protein (DBP) genetic variants have an influence on vitamin D status and, therefore, they may contribute to the development of autoimmune diseases.	Vitamin D	81-90	D-box binding PAR bZIP transcription factor	Homo sapiens	38-41
16753019-7	2006	Both mutations significantly impaired VDR ligand-binding capacity but had dissociated effects on CYP-24 and RelB promoter responses to vitamin D.	Vitamin D	135-144	RELB proto-oncogene, NF-kB subunit	Homo sapiens	108-112
16485114-12	2006	CONCLUSIONS: Our results demonstrate that the vitamin D analogue BXL-628 is able to suppress KGF-induced proliferation and invasion of AI-PC cells in vitro, prospecting a possible use of the drug, which is currently in phase II clinical studies for benign prostatic hyperplasia, in the treatment of advanced prostate cancer.	Vitamin D	46-55	fibroblast growth factor 7	Homo sapiens	93-96
16753019-9	2006	In the opposite, RelB responses to vitamin D were close to normal in L263R mutants but abolished in R391S mutants.	Vitamin D	35-44	RELB proto-oncogene, NF-kB subunit	Homo sapiens	17-21
16691293-8	2006	Combined with our previous findings that CYP3A4, not CYP24, plays the dominant role in hydroxylation of 1,25(OH)2D3 in human liver and intestine, our results indicate that SXR has a dual role in mediating vitamin D catabolism and drug-induced osteomalacia.	Vitamin D	205-214	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
16691293-8	2006	Combined with our previous findings that CYP3A4, not CYP24, plays the dominant role in hydroxylation of 1,25(OH)2D3 in human liver and intestine, our results indicate that SXR has a dual role in mediating vitamin D catabolism and drug-induced osteomalacia.	Vitamin D	205-214	nuclear receptor subfamily 1 group I member 2	Homo sapiens	172-175
16309986-1	2006	The vitamin D binding protein (DBP) is the major carrier protein for vitamin D metabolites in plasma.	Vitamin D	4-13	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
16547967-3	2006	Earlier studies have shown that in vivo treatment with vitamin D analogs ameliorates EAE in association with the inhibition of IL-12 production and Th1 differentiation.	Vitamin D	55-64	negative elongation factor complex member C/D, Th1l	Mus musculus	148-151
16547967-4	2006	The mechanisms in the regulation of Th1 response by vitamin D in EAE/MS are, however, not known.	Vitamin D	52-61	negative elongation factor complex member C/D, Th1l	Mus musculus	36-39
16547967-9	2006	These findings highlight the fact that vitamin D modulates JAK-STAT signaling pathway in IL-12/IFNgamma axis leading to Th1 differentiation and further suggest its use in the treatment of MS and other Th1 cell-mediated autoimmune diseases.	Vitamin D	39-48	interferon gamma	Mus musculus	95-103
16547967-9	2006	These findings highlight the fact that vitamin D modulates JAK-STAT signaling pathway in IL-12/IFNgamma axis leading to Th1 differentiation and further suggest its use in the treatment of MS and other Th1 cell-mediated autoimmune diseases.	Vitamin D	39-48	negative elongation factor complex member C/D, Th1l	Mus musculus	120-123
16547967-9	2006	These findings highlight the fact that vitamin D modulates JAK-STAT signaling pathway in IL-12/IFNgamma axis leading to Th1 differentiation and further suggest its use in the treatment of MS and other Th1 cell-mediated autoimmune diseases.	Vitamin D	39-48	negative elongation factor complex member C/D, Th1l	Mus musculus	201-204
16533909-8	2006	These results indicate that the activation of BMP/Smad signaling by the Gemini vitamin D(3) analog Ro3582 may be through the production of BMP ligands, including BMP-2 and BMP-6, and/or down-regulation of the inhibitory Smad6.	Vitamin D	79-88	bone morphogenetic protein 6	Homo sapiens	172-177
16309986-14	2006	In conclusion, serum 1,25(OH)(2)-vitamin D concentrations are codetermined by DBP-phenotypes and DBP-concentrations.	Vitamin D	33-42	D-box binding PAR bZIP transcription factor	Homo sapiens	78-81
16309986-14	2006	In conclusion, serum 1,25(OH)(2)-vitamin D concentrations are codetermined by DBP-phenotypes and DBP-concentrations.	Vitamin D	33-42	D-box binding PAR bZIP transcription factor	Homo sapiens	97-100
16680589-21	2006	Adequate supplementation with calcium and vitamin D, often necessary after subtotal PTX to suppress inadequate PTH and protect from recurrence, will prevent severe hypocalcemia and with the modern aluminium-diminishing dialysis regimen, development of adynamic bone disease appears less likely than feared.	Vitamin D	42-51	parathyroid hormone	Homo sapiens	111-114
16724654-2	2006	The vitamin D analog 19-Nor-1,25(OH)2-vitamin D2 (paricalcitol) and the prohormone 1alpha-OH-vitamin D2 (doxercalciferol) have been proposed as alternatives which may cause less hypercalcemia and elevated Ca x P, while still suppressing PTH.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	237-240
16789631-1	2006	In patients with pseudohypoparathyroidism, hormonal resistance first affects parathyroid hormone (PTH), which leads to calcipenia, a decrease in renal vitamin D activation, and a tendency to bone receptor remodeling.	Vitamin D	151-160	parathyroid hormone	Homo sapiens	77-96
16484501-9	2006	We performed promoter deletion analysis of the rat CYP3A9 promoter and identified one proximal vitamin D response element located at -119 to -133 from the transcriptional start site, which is responsible for a large part of the 1,25(OH)2D3 response, and two other vitamin D response elements located at -726 to -744 and at -754 to -776, which together are responsible for the increased sensitivity of CYP3A9 to 19nor-1,25(OH)2D2.	Vitamin D	95-104	cytochrome P450, family 3, subfamily a, polypeptide 9	Rattus norvegicus	51-57
16484501-9	2006	We performed promoter deletion analysis of the rat CYP3A9 promoter and identified one proximal vitamin D response element located at -119 to -133 from the transcriptional start site, which is responsible for a large part of the 1,25(OH)2D3 response, and two other vitamin D response elements located at -726 to -744 and at -754 to -776, which together are responsible for the increased sensitivity of CYP3A9 to 19nor-1,25(OH)2D2.	Vitamin D	95-104	cytochrome P450, family 3, subfamily a, polypeptide 9	Rattus norvegicus	401-407
16484501-9	2006	We performed promoter deletion analysis of the rat CYP3A9 promoter and identified one proximal vitamin D response element located at -119 to -133 from the transcriptional start site, which is responsible for a large part of the 1,25(OH)2D3 response, and two other vitamin D response elements located at -726 to -744 and at -754 to -776, which together are responsible for the increased sensitivity of CYP3A9 to 19nor-1,25(OH)2D2.	Vitamin D	264-273	cytochrome P450, family 3, subfamily a, polypeptide 9	Rattus norvegicus	51-57
16651450-2	2006	We show that menin is a transcriptional coactivator of the nuclear receptors for estrogen and vitamin D.	Vitamin D	94-103	menin 1	Homo sapiens	13-18
16674682-5	2006	On the other hand, TNAP is a reliable bone marker of vitamin D action, similar to calbindins in kidney and intestine, previously used for studies of vitamin D activity in ameloblasts.	Vitamin D	53-62	alkaline phosphatase, biomineralization associated	Rattus norvegicus	19-23
16674682-5	2006	On the other hand, TNAP is a reliable bone marker of vitamin D action, similar to calbindins in kidney and intestine, previously used for studies of vitamin D activity in ameloblasts.	Vitamin D	149-158	alkaline phosphatase, biomineralization associated	Rattus norvegicus	19-23
16596260-1	2006	The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	18-21
16596260-1	2006	The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively.	Vitamin D	63-72	calcium sensing receptor	Homo sapiens	124-128
16724947-0	2006	The role of insulin-like growth factor I components in the regulation of vitamin D.	Vitamin D	73-82	insulin like growth factor 1	Homo sapiens	12-40
16618780-0	2006	Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.	Vitamin D	21-30	mitogen-activated protein kinase 14	Homo sapiens	14-17
16618780-0	2006	Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.	Vitamin D	21-30	interleukin 6	Homo sapiens	39-52
16618780-0	2006	Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.	Vitamin D	188-197	mitogen-activated protein kinase 14	Homo sapiens	14-17
16310759-10	2006	Finally, we have proposed that PTH reference values should be established in healthy subjects with a normal vitamin D status.	Vitamin D	108-117	parathyroid hormone	Homo sapiens	31-34
16724947-4	2006	The mechanisms by which IGF-I may influence bone metabolism is not fully understood but they are a predictor of bone mass density and are positively associated with vitamin D concentrations.	Vitamin D	165-174	insulin like growth factor 1	Homo sapiens	24-29
16571177-10	2006	CONCLUSION: A high proportion of Irish postmenopausal women had low vitamin D status (&lt;50 nmol l(-1)) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers.	Vitamin D	68-77	parathyroid hormone	Homo sapiens	180-183
16549446-0	2006	Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3.	Vitamin D	85-94	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	39-46
16549446-2	2006	CYP27B1 is a cytochrome P450-containing hydroxylase expressed in kidney and other tissues that generates 1alpha,25(OH)2D3 from an inactive vitamin D precursor 25-hydroxycholecalciferol [25(OH)D3].	Vitamin D	139-148	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
16549446-9	2006	These are the first studies to demonstrate that nontransformed human mammary cells express CYP27B1, that they are growth inhibited by physiologically relevant concentrations of 25(OH)D3, and that they provide a biological mechanism linking vitamin D status to breast cancer risk.	Vitamin D	240-249	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	91-98
16455676-0	2006	Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Homo sapiens	20-28
16455676-0	2006	Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels.	Vitamin D	0-9	NFKB inhibitor alpha	Homo sapiens	52-64
16455676-2	2006	The aim of the present study is to examine whether this vitamin D inhibition of TNFalpha is mediated by its major transcription factor, nuclear factor-kappaB (NFkappaB).	Vitamin D	56-65	tumor necrosis factor	Homo sapiens	80-88
16455676-2	2006	The aim of the present study is to examine whether this vitamin D inhibition of TNFalpha is mediated by its major transcription factor, nuclear factor-kappaB (NFkappaB).	Vitamin D	56-65	nuclear factor kappa B subunit 1	Homo sapiens	159-167
16455676-7	2006	By using a reporter gene and EMSA we found that vitamin D markedly reduced NFkappaB activity.	Vitamin D	48-57	nuclear factor kappa B subunit 1	Homo sapiens	75-83
16455676-9	2006	Concurrently, vitamin D induced a significant increase in mRNA and protein levels of IkappaBalpha (approximately 6.5- and 4.5-fold, respectively).	Vitamin D	14-23	NFKB inhibitor alpha	Homo sapiens	85-97
16455676-10	2006	Elevated levels of IkappaBalpha can be explained by the vitamin D-induced prolongation of IkappaBalpha-mRNA half-life from 110 to 190 min and by the decrease in IkappaBalpha phosphorylation.	Vitamin D	56-65	NFKB inhibitor alpha	Homo sapiens	19-31
16455676-10	2006	Elevated levels of IkappaBalpha can be explained by the vitamin D-induced prolongation of IkappaBalpha-mRNA half-life from 110 to 190 min and by the decrease in IkappaBalpha phosphorylation.	Vitamin D	56-65	NFKB inhibitor alpha	Homo sapiens	90-102
16455676-10	2006	Elevated levels of IkappaBalpha can be explained by the vitamin D-induced prolongation of IkappaBalpha-mRNA half-life from 110 to 190 min and by the decrease in IkappaBalpha phosphorylation.	Vitamin D	56-65	NFKB inhibitor alpha	Homo sapiens	90-102
16455676-11	2006	CONCLUSIONS: Vitamin D up-regulates IkappaBalpha levels by increasing mRNA stability and decreasing IkappaBalpha phosphorylation.	Vitamin D	13-22	NFKB inhibitor alpha	Homo sapiens	36-48
16455676-11	2006	CONCLUSIONS: Vitamin D up-regulates IkappaBalpha levels by increasing mRNA stability and decreasing IkappaBalpha phosphorylation.	Vitamin D	13-22	NFKB inhibitor alpha	Homo sapiens	100-112
16289173-8	2006	In another study, we investigated the effects of a new Vitamin D analogue, BXL628, on invasion in response to KGF in the androgen-independent PC cell line DU145.	Vitamin D	55-64	fibroblast growth factor 7	Homo sapiens	110-113
16115686-3	2006	The goal of this study was to investigate the effect of ligating DBP with its two primary physiological ligands, Vitamin D and G-actin, on both binding to neutrophils and the ability to enhance chemotaxis to C5a.	Vitamin D	113-122	D-box binding PAR bZIP transcription factor	Homo sapiens	65-68
16646366-6	2006	The secondary hyperparathyroidism characterized by an increase of PTH associated to a low vitamin D and a normal calcium, is quite frequent.	Vitamin D	90-99	parathyroid hormone	Homo sapiens	66-69
16522742-1	2006	Farnesoid X receptor (FXR), the receptor for bile acids, including chenodeoxycholic acid (CDCA), is a member of the nuclear receptor superfamily, which also includes the receptors for retinoic acid, vitamin D (D3), thyroid hormone, thiazolidinedione and 22(R)-hydroxycholesterol.	Vitamin D	199-208	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	10-20
16483768-6	2006	Examination of the regulation of VDR target gene mRNA in DU-145 cells revealed that co-treatment of 1,25-(OH)(2)D(3) plus inhibitor of Vitamin D(3) metabolising enzymes co-ordinately upregulated CYP24, p21(waf1/cip1) and GADD45alpha.	Vitamin D	135-144	cyclin dependent kinase inhibitor 1A	Homo sapiens	202-215
16115686-3	2006	The goal of this study was to investigate the effect of ligating DBP with its two primary physiological ligands, Vitamin D and G-actin, on both binding to neutrophils and the ability to enhance chemotaxis to C5a.	Vitamin D	113-122	complement C5a receptor 1	Homo sapiens	208-211
16115686-6	2006	However, the active form of Vitamin D (1,25(OH)2D3) completely eliminated the chemotactic cofactor function of DBP.	Vitamin D	28-37	D-box binding PAR bZIP transcription factor	Homo sapiens	111-114
16115686-11	2006	These results indicate that the cell binding and co-chemotactic functions of DBP are not altered when the protein binds G-actin and/or Vitamin D.	Vitamin D	135-144	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
16467976-4	2006	Osteoblast function was measured as vitamin D-stimulated osteocalcin production and production of cytokines and factors involved in osteoclast activation and bone formation.	Vitamin D	36-45	bone gamma-carboxyglutamate protein	Homo sapiens	57-68
16467976-8	2006	Osteoblasts from osteoporotic men produced significantly less osteocalcin after vitamin D stimulation but had increased production of macrophage colony-stimulating factor (M-CSF) compared to controls.	Vitamin D	80-89	bone gamma-carboxyglutamate protein	Homo sapiens	62-73
16217589-13	2006	SCI also leads to impaired calcium and phosphate metabolism and the parathyroid hormone (PTH)-vitamin D axis.	Vitamin D	94-103	parathyroid hormone	Homo sapiens	68-87
16509457-0	2006	The impact of over-the-counter vitamin D supplements on vitamin D and parathyroid hormone levels in chronic kidney disease.	Vitamin D	31-40	parathyroid hormone	Homo sapiens	70-89
16509457-2	2006	The impact of supplementation with low-dose, nonactive forms of vitamin D (calciferol) on parathyroid hormone (PTH) levels in this population is unknown, however.	Vitamin D	64-73	parathyroid hormone	Homo sapiens	90-109
16371465-1	2006	The hormonally active form of vitamin D(3),1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is synthesized in the kidney through a tightly regulated reaction catalyzed by 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), the product of the CYP27B1 gene.	Vitamin D	30-39	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	173-214
16371465-1	2006	The hormonally active form of vitamin D(3),1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is synthesized in the kidney through a tightly regulated reaction catalyzed by 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), the product of the CYP27B1 gene.	Vitamin D	30-39	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	256-263
16439822-14	2006	CONCLUSION: This study not only confirms previous reports that despite vitamin D food supplementation a vitamin D deficiency is still a finding in elderly population in the Northern hemisphere, but also that a compensatory change in PTH levels concurrently occurs with a potential significance on bone strength and risk of fractures.	Vitamin D	104-113	parathyroid hormone	Homo sapiens	233-236
16397276-5	2006	The negative associations of vitamin D or calcium intakes with breast density were stronger among women with IGF-I levels above the median (beta = -2.8, P = 0.002 and beta = -2.5, P = 0.002, respectively) compared with those with IGF-I levels below or equal to the median (beta = -0.8, P = 0.38 and beta = -1.1, P = 0.21; P(interaction) = 0.09 and 0.16, respectively).	Vitamin D	29-38	insulin like growth factor 1	Homo sapiens	109-114
16397276-5	2006	The negative associations of vitamin D or calcium intakes with breast density were stronger among women with IGF-I levels above the median (beta = -2.8, P = 0.002 and beta = -2.5, P = 0.002, respectively) compared with those with IGF-I levels below or equal to the median (beta = -0.8, P = 0.38 and beta = -1.1, P = 0.21; P(interaction) = 0.09 and 0.16, respectively).	Vitamin D	29-38	insulin like growth factor 1	Homo sapiens	230-235
16397276-7	2006	This is the first study to report that the negative relation of vitamin D and calcium intakes with breast density may be seen primarily among women with high IGF-I or high IGFBP-3 levels.	Vitamin D	64-73	insulin like growth factor 1	Homo sapiens	158-163
16393446-18	2006	Mean vitamin D levels in the 47 patients with PTH levels above the reference range were significantly lower than vitamin D levels in the 238 patients within the reference range for PTH: mean 31.1 nmol/L, SD = 21.1 versus mean 46.5 nmol/L, SD = 24.8 (p = 0.000092).	Vitamin D	5-14	parathyroid hormone	Homo sapiens	46-49
16439822-0	2006	Seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec.	Vitamin D	37-46	parathyroid hormone	Homo sapiens	85-104
16439822-2	2006	OBJECTIVE: To identify the variability and correlation between serum levels of vitamin D and PTH in a sample of community-dwelling elderly patients in the Province of Quebec, Canada, where vitamin D and calcium are supplemented in the food.	Vitamin D	79-88	parathyroid hormone	Homo sapiens	93-96
16439822-13	2006	These low levels of vitamin D corresponded with an inverse pattern in the levels of PTH more importantly in early spring.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	84-87
17237623-6	2006	The vitamin D analogs modulated cell cycle regulators, including decreasing mRNA and protein levels of p21(Waf1/Cip1) (p21) and cyclin-dependent kinase 2 (cdk2), and increasing p27(Kip1) (p27) protein expression.	Vitamin D	4-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	103-116
16868704-2	2006	Parathyroid hormone (PTH) levels are affected by calcium, vitamin D, and phosphorus.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	0-19
16868704-2	2006	Parathyroid hormone (PTH) levels are affected by calcium, vitamin D, and phosphorus.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	21-24
17237623-6	2006	The vitamin D analogs modulated cell cycle regulators, including decreasing mRNA and protein levels of p21(Waf1/Cip1) (p21) and cyclin-dependent kinase 2 (cdk2), and increasing p27(Kip1) (p27) protein expression.	Vitamin D	4-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	103-106
17237623-7	2006	Vitamin D analogs induced apoptosis, caspase-3 cleavage and increased expression of pro-apoptotic MEKK-1.	Vitamin D	0-9	caspase 3	Homo sapiens	37-46
17237623-8	2006	Phosphorylation of Akt, MEK and ERK1/2 that promote cell growth and survival were inhibited by vitamin D analogs.	Vitamin D	95-104	AKT serine/threonine kinase 1	Homo sapiens	19-22
17237623-8	2006	Phosphorylation of Akt, MEK and ERK1/2 that promote cell growth and survival were inhibited by vitamin D analogs.	Vitamin D	95-104	mitogen-activated protein kinase kinase 7	Homo sapiens	24-27
17237623-8	2006	Phosphorylation of Akt, MEK and ERK1/2 that promote cell growth and survival were inhibited by vitamin D analogs.	Vitamin D	95-104	mitogen-activated protein kinase 3	Homo sapiens	32-38
16344723-13	2006	Because CYP3A4 is involved in the vitamin D metabolism, rickets may have been the underlying selecting factor.	Vitamin D	34-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	8-14
16538874-4	2006	It is important to remember to reduce or discontinue any medication, whether it is vitamin D, a calcium salt, or any other agent that significantly lowers PTH, especially when intact PTH levels decline rapidly (to &lt; 150 pg/mL) and serum calcium levels are higher than 10 mg/dL.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	155-158
16322405-0	2005	Functional analysis of the I.3, I.6, pII and I.4 promoters of CYP19 (aromatase) gene in human osteoblasts and their role in vitamin D and dexamethasone stimulation.	Vitamin D	124-133	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	62-67
17002490-1	2006	black triangle An oral formulation of paricalcitol has been developed for the prevention and treatment of secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease.black triangle Paricalcitol is a synthetic vitamin D analog that binds to the vitamin D receptor inducing suppression of parathyroid hormone (PTH) secretion.black triangle Oral paricalcitol was significantly more effective than placebo in treating secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease.	Vitamin D	232-241	parathyroid hormone	Homo sapiens	310-329
16413224-7	2005	When differentiation was induced by TGFbeta and vitamin D(3), 5LO expression became prominent, but expression levels of Sp1/3 and Egr-1 were the same as for control cells.	Vitamin D	48-57	arachidonate 5-lipoxygenase	Homo sapiens	62-65
16269129-7	2005	Both sterols inhibited the activity of DBP on VSMC, suggesting that vitamin D binding sites are important for initiating the activities of DBP on VSMC.	Vitamin D	68-77	D-box binding PAR bZIP transcription factor	Homo sapiens	39-42
16269129-7	2005	Both sterols inhibited the activity of DBP on VSMC, suggesting that vitamin D binding sites are important for initiating the activities of DBP on VSMC.	Vitamin D	68-77	D-box binding PAR bZIP transcription factor	Homo sapiens	139-142
16368037-13	2005	Mean vitamin D levels in the 30 patients with parathyroid hormone (PTH) levels above the reference range were significantly lower than levels in the 71 patients within the range: mean 19.9 nmol/L, SD = 16.2 versus mean 37.5 nmol/L, SD = 18.5 (p &lt; 0.0001).	Vitamin D	5-14	parathyroid hormone	Homo sapiens	46-65
16126938-8	2005	The NR ligands, vitamin D(3), trans/cis RA, glucocorticoids, and thiazolidines, induce dramatic changes in the physiology of cells harboring high Wnt/beta-catenin/Tcf activity.	Vitamin D	16-25	hepatocyte nuclear factor 4 alpha	Homo sapiens	163-166
16322405-0	2005	Functional analysis of the I.3, I.6, pII and I.4 promoters of CYP19 (aromatase) gene in human osteoblasts and their role in vitamin D and dexamethasone stimulation.	Vitamin D	124-133	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	69-78
16322405-7	2005	RESULTS: Vitamin D and dexamethasone were potent stimulators of CYP19 transcription, while testosterone and 17beta-estradiol stimulated moderately.	Vitamin D	9-18	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	64-69
19079903-1	2005	Evidence from different directions, including observational and experimental studies, points to a role of vitamin D status in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus (T2DM).	Vitamin D	106-115	insulin	Homo sapiens	165-172
19079903-4	2005	It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6.	Vitamin D	46-55	insulin	Homo sapiens	99-106
15928802-10	2005	However, after the threshold vitamin D level of 120 nmol/l, all PTH values were below 65 ng/l.	Vitamin D	29-38	parathyroid hormone	Homo sapiens	64-67
19079903-4	2005	It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6.	Vitamin D	46-55	tumor necrosis factor	Homo sapiens	356-365
19079903-4	2005	It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6.	Vitamin D	46-55	interleukin 6	Homo sapiens	371-375
19079903-4	2005	It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6.	Vitamin D	208-217	insulin	Homo sapiens	99-106
19079903-4	2005	It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6.	Vitamin D	208-217	tumor necrosis factor	Homo sapiens	356-365
19079903-4	2005	It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-alpha,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines - particularly TNF-alpha, and IL-6.	Vitamin D	208-217	interleukin 6	Homo sapiens	371-375
16002434-2	2005	The vitamin D receptor (VDR) is a ligand-regulated transcription factor that recognizes cognate vitamin D response elements (VDREs) formed by direct or everted repeats of PuG(G/T)TCA motifs separated by 3 or 6 bp (DR3 or ER6).	Vitamin D	4-13	TNF receptor superfamily member 25	Homo sapiens	214-217
16203744-9	2005	The correlations between SNAIL, CDH1, VDR and ZEB1 and the association between reduced expression of CDH1 and VDR and aggressive tumor characteristics emphasize the value of analyzing these genes in colon cancer patients for prognostic purposes and for predicting response to possible therapies with vitamin D or its analogs.	Vitamin D	300-309	cadherin 1	Homo sapiens	101-105
16278362-0	2005	Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.	Vitamin D	55-64	parathyroid hormone	Homo sapiens	27-46
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	88-97	zinc finger protein 318	Homo sapiens	463-482
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	88-97	renin	Homo sapiens	491-496
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	140-149	zinc finger protein 318	Homo sapiens	463-482
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	140-149	renin	Homo sapiens	491-496
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	140-149	zinc finger protein 318	Homo sapiens	463-482
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	140-149	renin	Homo sapiens	491-496
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	140-149	zinc finger protein 318	Homo sapiens	463-482
16221197-12	2005	The following three potential mechanisms may be important for the protective effects of vitamin D against cardiovascular disease mortality: vitamin D can inhibit various aspects of inflammation, which have been established as a key pathogenic mechanism in atherosclerosis; vitamin D exerts an antiproliferative effect on myocardial cell hypertrophy and proliferation, which underlies the pathogenesis of congestive heart failure; and vitamin D acts as a negative endocrine regulator for the renin-angiotensin system, which itself plays an important independent role in hypertension and cardiovascular health.	Vitamin D	140-149	renin	Homo sapiens	491-496
16177194-10	2005	The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice.	Vitamin D	108-117	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	47-59
16236546-2	2005	To assess the role of vitamin D receptor (VDR) in apo AI gene expression, we investigated the effect of 1alpha, 25-dihydroxycholecalciferol (1, 25-(OH)2 D3) as well as the vitamin D antagonist ZK-191784 (ZK), on apo AI gene expression and promoter activity in the human hepatoma cell line HepG2.	Vitamin D	22-31	apolipoprotein A1	Homo sapiens	50-56
16236546-5	2005	Mapping of the vitamin D response element showed that suppression required a region of the apo AI gene promoter identified previously to contain site A.	Vitamin D	15-24	apolipoprotein A1	Homo sapiens	91-97
16236546-11	2005	This effect requires the VDR as well as a vitamin D response element in the apo AI promoter.	Vitamin D	42-51	apolipoprotein A1	Homo sapiens	76-82
16197570-7	2005	These mechanisms include the inhibition of vascular smooth muscle proliferation, the suppression of vascular calcification, the down regulation of pro-inflammatory cytokines, the up regulation of anti-inflammatory cytokines, and the action of vitamin D as a negative endocrine regulator of the renin-angiotensin system.	Vitamin D	243-252	renin	Homo sapiens	294-299
16160737-13	2005	These studies emphasize that much remains to be learned regarding the normal regulation of vitamin D metabolism and bone formation in response to PTH and PTHrP in humans.	Vitamin D	91-100	parathyroid hormone	Homo sapiens	146-149
16076940-1	2005	BACKGROUND: Evidence suggests that vitamin D status in adults, as assessed by serum 25-hydroxyvitamin D (25-OHD), is positively associated with calcium absorption fraction and inversely associated with serum PTH.	Vitamin D	35-44	parathyroid hormone	Homo sapiens	208-211
16076940-8	2005	CONCLUSIONS: These data suggest that in adolescents, especially in the presence of vitamin D insufficiency, PTH secretion increases to adapt to higher rates of bone formation associated with growth.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	108-111
16370566-1	2005	Vitamin D deficiency rickets occasionally resembles pseudohypoparathyroidism type II (PHP type II) with respect to the response to exogenous PTH in the presence of hypocalcemia.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	141-144
16162105-4	2005	Recent studies have suggested that vitamin D signaling pathways may interact with and regulate TGFbeta-1 mediated events.	Vitamin D	35-44	transforming growth factor, beta 1	Rattus norvegicus	95-104
16177194-10	2005	The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice.	Vitamin D	152-161	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	47-59
16177194-12	2005	The tumor expression of VDR and 1alpha-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D.	Vitamin D	110-119	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	24-44
16323060-0	2005	Vitamin D, tamoxifen and beta-estradiol modulate breast cancer cell growth and interleukin-6 and metalloproteinase-2 production in three-dimensional co-cultures of tumor cell spheroids with endothelium.	Vitamin D	0-9	interleukin 6	Homo sapiens	79-92
16323060-4	2005	The study was also designed to investigate whether vitamin D might influence interleukin-6 (IL-6) and metalloproteinase-2 (MMP-2) production in a co-culture of T47D cell spheroids with an endothelial cell monolayer in the presence of beta-estradiol and TAM.	Vitamin D	51-60	interleukin 6	Homo sapiens	77-90
16323060-4	2005	The study was also designed to investigate whether vitamin D might influence interleukin-6 (IL-6) and metalloproteinase-2 (MMP-2) production in a co-culture of T47D cell spheroids with an endothelial cell monolayer in the presence of beta-estradiol and TAM.	Vitamin D	51-60	interleukin 6	Homo sapiens	92-96
16037412-10	2005	CONCLUSIONS: The results of the present study are in agreement with previous data supporting an association of increased PTH and decreased vitamin D metabolite concentrations with obesity.	Vitamin D	139-148	parathyroid hormone	Homo sapiens	121-124
16323060-8	2005	Addition of vitamin D further inhibited MMP-2 production, but enhanced the production of IL-6 as was shown by ELISA assay.	Vitamin D	12-21	interleukin 6	Homo sapiens	89-93
15972816-0	2005	Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1.	Vitamin D	89-98	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	44-51
16272626-6	2005	It was possible to subdue the rise of intact PTH with vitamin D.	Vitamin D	54-63	parathyroid hormone	Homo sapiens	45-48
16299679-2	2005	Parathyroid hormone (PTH) gene expression and hormone secretion is regulated mainly by serum calcium, with a post-transcriptional effect, and by vitamin D with a transcriptional effect.	Vitamin D	145-154	parathyroid hormone	Homo sapiens	0-19
16299679-2	2005	Parathyroid hormone (PTH) gene expression and hormone secretion is regulated mainly by serum calcium, with a post-transcriptional effect, and by vitamin D with a transcriptional effect.	Vitamin D	145-154	parathyroid hormone	Homo sapiens	21-24
16076355-1	2005	Activated vitamin D continues to be the major treatment for suppressing parathyroid hormone (PTH) levels in dialysis patients who have secondary hyperparathyroidism.	Vitamin D	10-19	parathyroid hormone	Homo sapiens	72-91
15964254-16	2005	Given the poor vitamin D status of young Finnish men, intervention studies of vitamin D supplementation to lower serum PTH levels and to possibly reduce the incidence of stress fractures are warranted.	Vitamin D	78-87	parathyroid hormone	Homo sapiens	119-122
16087726-2	2005	In the present report, functional mapping of the EGFR promoter in BT549 cells has revealed a sequence of DNA between nucleotide positions -536 and -478 that resembles a consensus vitamin D response element (VDRE) and confers a vitamin D response upon both the homologous and a minimal heterologous promoter.	Vitamin D	179-188	epidermal growth factor receptor	Homo sapiens	49-53
16087726-2	2005	In the present report, functional mapping of the EGFR promoter in BT549 cells has revealed a sequence of DNA between nucleotide positions -536 and -478 that resembles a consensus vitamin D response element (VDRE) and confers a vitamin D response upon both the homologous and a minimal heterologous promoter.	Vitamin D	227-236	epidermal growth factor receptor	Homo sapiens	49-53
15868280-1	2005	The major transporter of vitamin D metabolites in the circulation is the multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, vitamin D-binding protein, or DBP.	Vitamin D	25-34	D-box binding PAR bZIP transcription factor	Homo sapiens	191-194
15985530-5	2005	The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR).	Vitamin D	39-48	cathelicidin antimicrobial peptide	Homo sapiens	80-84
16229345-11	2005	Finally, PTH was inversely correlated with vitamin D intake and the animal/total calcium intake ratio (r = -0.18 and r = -0.22, p &lt; 0.01), while no significant results were achieved for the vegetable calcium.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	9-12
16061850-0	2005	Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	75-82
16261991-4	2005	Vitamin D supplementation stimulated intestinal calcium absorption with prevention of the abnormal elevation of serum PTH levels and prevented hypocalcemia in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet.	Vitamin D	0-9	parathyroid hormone	Rattus norvegicus	118-121
15551058-0	2005	Vitamin D status as the major factor determining the circulating levels of parathyroid hormone: a study in normal subjects.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	75-94
15551058-9	2005	In subjects with vitamin D insufficiency (n = 53) [25(OH)D &lt; 30 nmol/l], mean serum levels of parathyroid hormone were significantly higher (P &lt; 0.001) than those in subjects of similar age with normal vitamin status (n = 209) with all the assays employed.	Vitamin D	17-26	parathyroid hormone	Homo sapiens	97-116
15769827-0	2005	Is vitamin D indispensable for Ca2+ homeostasis: lessons from knockout mouse models?	Vitamin D	3-12	carbonic anhydrase 2	Mus musculus	31-34
15779069-9	2005	Calcium and vitamin D supplementation resulted in an increase in 25-hydroxy-vitamin D (P &lt; 0.001), 1,25-dihydroxy-vitamin D (P = 0.048) and osteocalcin (P = 0.045), whereas levels of parathyroid hormone were decreased (P = 0.007).	Vitamin D	12-21	bone gamma-carboxyglutamate protein	Homo sapiens	143-154
15904673-0	2005	Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	65-74
15904673-11	2005	We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required.	Vitamin D	48-57	tumor necrosis factor	Homo sapiens	94-103
15904673-11	2005	We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required.	Vitamin D	48-57	tumor necrosis factor	Homo sapiens	114-123
15885502-5	2005	Northern analysis of GRWD1 message levels in the myeloid cell line HL-60 undergoing differentiation induced by vitamin D(3) or retinoic acid demonstrate downregulation coincident with slowing of cellular proliferation.	Vitamin D	111-120	glutamate rich WD repeat containing 1	Homo sapiens	21-26
15843402-1	2005	In humans, loss-of-function mutations in parathyroid hormone (PTH) and 25-hydroxyvitamin D3-1alpha-hydroxylase [1alpha(OH)ase] genes lead to isolated hypoparathyroidism and vitamin D-dependent rickets type I, respectively.	Vitamin D	81-90	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	112-125
15983179-8	2005	Baseline vitamin D intake was negatively associated with serum parathyroid hormone (r = -0.29, p &lt;.0001), and not associated with bone mineral density or bone resorption.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	63-82
15820216-10	2005	Dietary vitamin D or exogenous 1,25(OH)2D3 more than doubled CaT1 mRNA levels, and this regulation was independent of dietary or serum calcium.	Vitamin D	8-17	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	61-65
15854055-0	2005	Vitamin D induces the antimicrobial protein hCAP18 in human skin.	Vitamin D	0-9	cathelicidin antimicrobial peptide	Homo sapiens	44-50
15891005-4	2005	Treatment with active vitamin D can increase vitamin D receptor expression, inhibit growth of parathyroid tumors, and reduce PTH levels in patients with hyperparathyroidism (HPT).	Vitamin D	22-31	parathyroid hormone	Homo sapiens	125-128
15960864-0	2005	Vitamin D status and its relationship with parathyroid hormone and bone mineral status in older adolescents.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	43-62
15833842-6	2005	All retained 1,25-(OH)(2) vitamin D(3)-induced expression of osteoblastic markers: collagen type I, alkaline phosphatase, and osteocalcin.	Vitamin D	26-35	bone gamma-carboxyglutamate protein	Homo sapiens	126-137
15710334-1	2005	The aim of this study was to investigate whether the vitamin D analogue KH 1060 could exert a suppressive action on Tumor necrosis factor-alpha (TNF-alpha).	Vitamin D	53-62	tumor necrosis factor	Homo sapiens	116-143
15710334-1	2005	The aim of this study was to investigate whether the vitamin D analogue KH 1060 could exert a suppressive action on Tumor necrosis factor-alpha (TNF-alpha).	Vitamin D	53-62	tumor necrosis factor	Homo sapiens	145-154
15770204-5	2005	These findings suggest that SNAIL may be associated with loss of responsiveness to vitamin D analogues and may thus be used as an indicator of patients who are unlikely to respond to this therapy.	Vitamin D	83-92	snail family transcriptional repressor 1	Homo sapiens	28-33
15578590-4	2005	We also show that LCA-VDR stimulates transcription of gene reporter constructs containing DR3 and ER6 vitamin D responsive elements (VDREs) from the human CYP3A4 gene.	Vitamin D	102-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-161
15781675-1	2005	OBJECTIVE: To establish the unique and common clinical and microscopic characteristics of the alopecias associated with vitamin D-dependent rickets (VDDR) type IIA and with hairless gene mutations.	Vitamin D	120-129	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	149-153
15781666-0	2005	19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.	Vitamin D	41-50	nuclear receptor subfamily 4 group A member 3	Homo sapiens	3-8
15781666-1	2005	Recently, we reported that a novel, noncalcemic vitamin D analogue (19-nor-1,25(OH)2D2; paricalcitol) had anticancer activity.	Vitamin D	48-57	nuclear receptor subfamily 4 group A member 3	Homo sapiens	71-76
15792756-0	2005	Intraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementation.	Vitamin D	125-134	parathyroid hormone	Homo sapiens	15-34
15698460-8	2005	Vitamin D was potentially underused in up to 34% of patients with high PTH, and overused in up to 46% of patients with low PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	71-74
15843891-7	2005	We demonstrate that apoptosis induced by gamma-radiation or the vitamin D analogue EB1089 in the non-tumourigenic human colorectal adenoma-derived S/RG/C2 cell line, was preceded by a decrease in nuclear and an increase in cytoplasmic BAG-1 expression.	Vitamin D	64-73	BAG cochaperone 1	Homo sapiens	235-240
15730407-4	2005	Instead vitamin D insufficiency is defined as the lowest threshold value for plasma 25OHD (around 50 nmol/l) that prevents secondary hyperparathyroidism, increased bone turnover, bone mineral loss, or seasonal variations in plasma PTH.	Vitamin D	8-17	parathyroid hormone	Homo sapiens	231-234
15698460-8	2005	Vitamin D was potentially underused in up to 34% of patients with high PTH, and overused in up to 46% of patients with low PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	123-126
15546903-4	2005	The ratio of rates of 24-hydroxylation of 1 alpha-hydroxyvitamin D(3) (1 alpha OHD(3)), 1 alpha OHD(2), and vitamin D(2) by CYP3A4 was 3.6/2.8/1.0.	Vitamin D	57-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130
15730054-5	2005	Studies point to a prominent role of calcium, phosphate and vitamin D as regulators of PTH and parathyroid cell proliferation.	Vitamin D	60-69	parathyroid hormone	Homo sapiens	87-90
15689574-1	2005	PTH is a major systemic regulator of the concentrations of calcium, phosphate, and active vitamin D metabolites in blood and of cellular activity in bone.	Vitamin D	90-99	parathyroid hormone	Homo sapiens	0-3
15685554-7	2005	At the long-term level, vitamin D(3) , lipopolysaccharide, thyroid hormone T(3), dexamethasone, platelet-derived growth factor, endothelin 1, and interleukin 1beta up-regulate connexin 43 protein and messenger RNA expression and enhance intercellular communication.	Vitamin D	24-33	interleukin 1 beta	Rattus norvegicus	146-163
16278774-4	2005	These are the vitamin D receptor as well as two major vitamin D metabolising enzymes, CYP27B1, responsible for synthesis of 1,25(OH)2D and CYP24, responsible for catabolism of vitamin D metabolites.	Vitamin D	54-63	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	86-93
15546903-10	2005	Thus, CYP3A4 is both a 24- and 25-hydroxylase for vitamin D(2), 1 alpha OHD(2), and 1 alpha OHD(3).	Vitamin D	50-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	6-12
15733015-1	2005	Paricalcitol (Zemplar) is a synthetic vitamin D(2) analogue that inhibits the secretion of parathyroid hormone (PTH) through binding to the vitamin D receptor.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	91-110
15691891-1	2005	The enzyme 25-hydroxyvitamin D 1alpha-hydroxylase, or CYP27B1, is the key enzyme in the two-step activation process of vitamin D to 1,25-dihydroxyvitamin D (1,25D).	Vitamin D	21-30	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	54-61
15691891-7	2005	Vitamin D deficiency resulted in an increase in both the reporter gene and CYP27B1 expression.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	75-82
15691891-8	2005	Interestingly, the increase in CYP27B1 mRNA levels was substantially higher than the increase in reporter gene expression, suggesting either that there is a post-transcriptional mechanism that increases the amount of CYP27B1 mRNA or that other regulatory elements are required to maximize the effect of vitamin D deficiency.	Vitamin D	303-312	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	31-38
15691891-8	2005	Interestingly, the increase in CYP27B1 mRNA levels was substantially higher than the increase in reporter gene expression, suggesting either that there is a post-transcriptional mechanism that increases the amount of CYP27B1 mRNA or that other regulatory elements are required to maximize the effect of vitamin D deficiency.	Vitamin D	303-312	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	217-224
15691891-9	2005	These findings demonstrate that the 1501 bp 5" flanking region of the CYP27B1 gene directs expression to the proximal convoluted tubules of the kidney and is responsible for increasing transcriptional activity when dietary calcium and vitamin D levels are depleted.	Vitamin D	235-244	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	70-77
15802034-3	2005	It is known that insulin resistance in uraemia may be improved with erythropoietin (EPO) and vitamin D therapy.	Vitamin D	93-102	insulin	Homo sapiens	17-24
15733015-1	2005	Paricalcitol (Zemplar) is a synthetic vitamin D(2) analogue that inhibits the secretion of parathyroid hormone (PTH) through binding to the vitamin D receptor.	Vitamin D	38-47	parathyroid hormone	Homo sapiens	112-115
15593122-1	2005	Vitamin D-deficient IL-10 knockout (KO) mice develop accelerated inflammatory bowel disease (IBD).	Vitamin D	0-9	interleukin 10	Mus musculus	20-25
15471965-8	2005	Treatment with vitamin D [1,25(OH)2VD]-induced D2 activity by 2- to 3-fold as early as 24 h, regardless of the level of cell confluence, but estradiol, PTH, forskolin, leptin, TNFalpha, TGFbeta, and dexamethasone did not affect D2.	Vitamin D	15-24	tumor necrosis factor	Mus musculus	176-184
15593122-2	2005	Removing dietary calcium from the diets of vitamin D-deficient IL-10 KO mice increased the severity of IBD.	Vitamin D	43-52	interleukin 10	Mus musculus	63-68
15659793-8	2004	Osteocalcin gene expression was enhanced by VD/VD-R through the vitamin D-responsive element in the promoter.	Vitamin D	64-73	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
15589699-9	2005	The widespread distribution of 1alpha-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain.	Vitamin D	70-79	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	31-43
15630441-3	2005	provide convincing evidence that PXR can also induce vitamin D deficiency and bone disease because of its ability to cross-talk with the vitamin D-responsive gene that catabolizes 25-hydroxy-vitamin D and 1,25-dihydroxyvitamin D.	Vitamin D	53-62	nuclear receptor subfamily 1 group I member 2	Homo sapiens	33-36
15630441-3	2005	provide convincing evidence that PXR can also induce vitamin D deficiency and bone disease because of its ability to cross-talk with the vitamin D-responsive gene that catabolizes 25-hydroxy-vitamin D and 1,25-dihydroxyvitamin D.	Vitamin D	137-146	nuclear receptor subfamily 1 group I member 2	Homo sapiens	33-36
15630441-4	2005	This cross-talk behavior has important health ramifications and can be mitigated through the identification and treatment of PXR-induced vitamin D deficiency.	Vitamin D	137-146	nuclear receptor subfamily 1 group I member 2	Homo sapiens	125-128
15868563-1	2005	BACKGROUND/PURPOSE: The aim of this study was to develop a surgically implantable controlled release delivery system for parathyroid hormone (PTH) that will maintain calcium homeostasis without the adverse side effects of long-term calcium and vitamin D replacement and can be used for the treatment of hypoparathyroidism.	Vitamin D	244-253	parathyroid hormone	Homo sapiens	121-140
16050413-2	2005	In this second article we will analyze the new vitamin D analogs, capable of decreasing parathyroid hormone (PTH) levels with a lower effect on intestinal calcium and phosphorus absorption.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	88-107
15574355-7	2005	Eight types of missense mutations in the CYP27B1 gene found in vitamin D-dependent rickets type I (VDDR-I) patients completely abolished the 1alpha-hydroxylase activity.	Vitamin D	63-72	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	41-48
15574355-7	2005	Eight types of missense mutations in the CYP27B1 gene found in vitamin D-dependent rickets type I (VDDR-I) patients completely abolished the 1alpha-hydroxylase activity.	Vitamin D	63-72	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	99-105
15574355-12	2005	Surprisingly, more than 70 % of the vitamin D metabolites observed in a living body were found to be the products formed by the activities of CYP27A1, CYP27B1 and CYP24A1.	Vitamin D	36-45	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	151-158
15630458-10	2005	We demonstrated that PXR binds to and transactivates the 2 proximal vitamin D-responsive elements of the human CYP24 promoter.	Vitamin D	68-77	nuclear receptor subfamily 1 group I member 2	Homo sapiens	21-24
15630458-11	2005	These data suggest that xenobiotics and drugs can modulate CYP24 gene expression and alter vitamin D(3) hormonal activity and calcium homeostasis through the activation of PXR.	Vitamin D	91-100	nuclear receptor subfamily 1 group I member 2	Homo sapiens	172-175
15780503-10	2005	PTH secretion should be down-regulated by good vitamin D status -- achieved through supplementation or regular uv exposure -- and by vegan diets moderately low in bioavailable phosphate.	Vitamin D	47-56	parathyroid hormone	Homo sapiens	0-3
15780504-5	2005	In a recent clinical trial targeting elderly chronically ill patients, administration of vitamin D reduced serum levels of both CRP and IL-6; further such studies should assess the impact of physiologically meaningful doses of vitamin D on acute phase reactants in elderly subjects likely to have poor vitamin D status.	Vitamin D	89-98	C-reactive protein	Homo sapiens	128-131
15780504-5	2005	In a recent clinical trial targeting elderly chronically ill patients, administration of vitamin D reduced serum levels of both CRP and IL-6; further such studies should assess the impact of physiologically meaningful doses of vitamin D on acute phase reactants in elderly subjects likely to have poor vitamin D status.	Vitamin D	89-98	interleukin 6	Homo sapiens	136-140
15175848-13	2005	We found that the widely used cutoff for vitamin D deficiency is associated with increasing PTH levels and is below the inflection point for a change in the slope of the regression line.	Vitamin D	41-50	parathyroid hormone	Homo sapiens	92-95
15542054-8	2004	However, a 1,25-(OH)(2)D(3) suppression of several intra-/intercellular matrix modeling proteins such as sodium/potassium ATPase, claudin 3, aquaporin 8, cadherin 17, and RhoA suggests a vitamin D regulation of tight junction permeability and paracellular calcium transport.	Vitamin D	187-196	aquaporin 8	Rattus norvegicus	141-152
15876428-0	2004	Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells.	Vitamin D	40-49	GLI family zinc finger 2	Homo sapiens	131-136
15562190-7	2004	CONCLUSIONS: These results show an inverse association between vitamin D status and diabetes, possibly involving insulin resistance, in non-Hispanic whites and Mexican Americans.	Vitamin D	63-72	insulin	Homo sapiens	113-120
15531704-0	2004	How to consider low serum vitamin D as a risk factor for insulin resistance?	Vitamin D	26-35	insulin	Homo sapiens	57-64
15876428-0	2004	Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells.	Vitamin D	90-99	GLI family zinc finger 2	Homo sapiens	131-136
15299011-0	2004	The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain.	Vitamin D	4-13	bone gamma-carboxyglutamate protein	Homo sapiens	45-56
15531500-8	2004	Serum PTH appears to be associated with increased mortality in the frail elderly independent of vitamin D status, renal function, bone mass, and measures of general health.	Vitamin D	96-105	parathyroid hormone	Homo sapiens	6-9
15299011-4	2004	Our studies demonstrate that both the distal and proximal DNase I-hypersensitive sites characteristic of the transcriptionally active OC promoter are not enhanced in the absence of a functional vitamin D response element (VDRE).	Vitamin D	194-203	bone gamma-carboxyglutamate protein	Homo sapiens	134-136
15165995-7	2004	Treatment of wild-type mice with 1,25-dihydroxyvitamin D3 or vitamin D analog markedly stimulated renal NaSi-1 mRNA expression.	Vitamin D	47-56	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	104-110
15297458-0	2004	Suppression of the human parathyroid hormone promoter by vitamin D involves displacement of NF-Y binding to the vitamin D response element.	Vitamin D	57-66	parathyroid hormone	Homo sapiens	25-44
15297458-0	2004	Suppression of the human parathyroid hormone promoter by vitamin D involves displacement of NF-Y binding to the vitamin D response element.	Vitamin D	112-121	parathyroid hormone	Homo sapiens	25-44
15297458-1	2004	An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	97-116
15297458-1	2004	An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex.	Vitamin D	50-59	parathyroid hormone	Homo sapiens	118-122
15297458-8	2004	Furthermore, findings suggest that the repressive effects of vitamin D on hPTH gene transcription may involve displacement of NF-Y binding to the proximal site by the VDR heterodimer, which subsequently attenuates synergistic transactivation.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	74-78
15165995-2	2004	One key protein involved in transcellular transport of sulfate is the sodium-sulfate cotransporter NaSi-1, and previous studies suggest that vitamin D modulates sulfate homeostasis by regulating NaSi-1 expression.	Vitamin D	141-150	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	99-105
15165995-2	2004	One key protein involved in transcellular transport of sulfate is the sodium-sulfate cotransporter NaSi-1, and previous studies suggest that vitamin D modulates sulfate homeostasis by regulating NaSi-1 expression.	Vitamin D	141-150	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	195-201
15368360-2	2004	Ids are inhibitory helix-loop-helix (HLH) transcription factors and expression of Id genes in osteoblasts is under the control of calciotropic agents such as BMP and vitamin D.	Vitamin D	166-175	iduronate 2-sulfatase	Mus musculus	0-3
15165995-6	2004	Similar results were observed in VDR knockout mice after their blood ionized calcium levels and rachitic bone phenotype were normalized by dietary means, indicating that vitamin D regulation of NaSi-1 expression and sulfate metabolism is independent of its role in calcium metabolism.	Vitamin D	170-179	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	194-200
15377346-8	2004	Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression.	Vitamin D	27-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	273-277
15336539-8	2004	The promyelocytic leukemia cell line HL60 treated with vitamin D showed higher expression of AQP9 and hypersensitivity to Trisenox and Sb(III).	Vitamin D	55-64	aquaporin 9	Homo sapiens	93-97
15577116-3	2004	There is a need to monitor serum corrected (ionized) calcium concentration and parathyroid hormone (PTH) in order to administer vitamin D and its analogues safely.	Vitamin D	128-137	parathyroid hormone	Homo sapiens	79-98
15577115-2	2004	Vitamin D therapy brings about suppression of PTH and ameliorates oseitis fibrosa.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	46-49
15322146-4	2004	The promoters of the human cathelicidin antimicrobial peptide (camp) and defensin beta2 (defB2) genes contain consensus vitamin D response elements that mediate 1,25(OH)(2)D(3)-dependent gene expression.	Vitamin D	120-129	cathelicidin antimicrobial peptide	Homo sapiens	27-61
15322146-4	2004	The promoters of the human cathelicidin antimicrobial peptide (camp) and defensin beta2 (defB2) genes contain consensus vitamin D response elements that mediate 1,25(OH)(2)D(3)-dependent gene expression.	Vitamin D	120-129	defensin beta 4A	Homo sapiens	73-87
15322146-4	2004	The promoters of the human cathelicidin antimicrobial peptide (camp) and defensin beta2 (defB2) genes contain consensus vitamin D response elements that mediate 1,25(OH)(2)D(3)-dependent gene expression.	Vitamin D	120-129	defensin beta 4A	Homo sapiens	89-94
15322208-1	2004	The active metabolite of vitamin D (1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))) is known to modulate the immune response in Th1 cell-directed diseases.	Vitamin D	25-34	negative elongation factor complex member C/D, Th1l	Mus musculus	126-129
15334367-0	2004	Elevated serum parathyroid hormone concentration in eucalcemic patients after parathyroidectomy for primary hyperparathyroidism and its relationship to vitamin D profile.	Vitamin D	152-161	parathyroid hormone	Homo sapiens	15-34
15296470-11	2004	Age, low calcium and vitamin D intakes were explanatory variables for serum PTH.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	76-79
15296474-1	2004	BACKGROUND: CYP27B1 hydroxylase catalyzes the conversion of 25 hydroxyvitamin D(3) (25OHD(3)) to 1,25(OH)(2)D(3), the most active natural vitamin D metabolite, which plays a role in the regulation of immunity and cell proliferation.	Vitamin D	70-79	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	12-19
15461740-2	2004	Data from the literature show that the majority of dialysis patients treated with traditional calcium-containing phosphorus binders and vitamin D or vitamin D analogue preparations have serum parathyroid hormone (PTH), calcium, and phosphorus levels outside these strict K/DOQI target ranges.	Vitamin D	136-145	parathyroid hormone	Homo sapiens	192-211
15461740-2	2004	Data from the literature show that the majority of dialysis patients treated with traditional calcium-containing phosphorus binders and vitamin D or vitamin D analogue preparations have serum parathyroid hormone (PTH), calcium, and phosphorus levels outside these strict K/DOQI target ranges.	Vitamin D	149-158	parathyroid hormone	Homo sapiens	192-211
15761507-0	2004	[Disturbances of calcium-PTH-vitamin D axis in chronic liver diseases].	Vitamin D	29-38	parathyroid hormone	Homo sapiens	25-28
15761507-1	2004	Disturbances in Calcium-PTH-Vitamin D axis are frequently associated with chronic liver diseases (CLD).	Vitamin D	28-37	parathyroid hormone	Homo sapiens	24-27
15761507-4	2004	Therefore, other factors (i.e. inadequate diet, reduced exposure to sun light) would be responsible for the disturbances in calcium-PTH-vitamin D axis.	Vitamin D	136-145	parathyroid hormone	Homo sapiens	132-135
15761507-7	2004	Thus, the clinical relevance of calcium-PTH-vitamin D disturbances in hepatic osteodystrophy is still under discussion.	Vitamin D	44-53	parathyroid hormone	Homo sapiens	40-43
15128933-1	2004	The synthesis of bioactive vitamin D requires hydroxylation at the 1 alpha and 25 positions by cytochrome P450 enzymes in the kidney and liver, respectively.	Vitamin D	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	95-110
15211579-1	2004	Resistance to the action of vitamin D (D) occurs in response to tumor necrosis factor-alpha (TNF-alpha), an effect mediated by nuclear factor kappa B (NfkappaB).	Vitamin D	28-37	tumor necrosis factor	Rattus norvegicus	64-91
15211579-1	2004	Resistance to the action of vitamin D (D) occurs in response to tumor necrosis factor-alpha (TNF-alpha), an effect mediated by nuclear factor kappa B (NfkappaB).	Vitamin D	28-37	tumor necrosis factor	Rattus norvegicus	93-102
15211579-3	2004	These treatments caused stable incorporation of p65 into the transcription complex bound to the vitamin D response element (VDRE) of the osteocalcin promoter.	Vitamin D	96-105	synaptotagmin 1	Rattus norvegicus	48-51
15211579-3	2004	These treatments caused stable incorporation of p65 into the transcription complex bound to the vitamin D response element (VDRE) of the osteocalcin promoter.	Vitamin D	96-105	bone gamma-carboxyglutamate protein	Rattus norvegicus	137-148
15211579-11	2004	These results show that TNF-alpha inhibition of vitamin D-action includes stable integration of p65 in the VDR transcription complex.	Vitamin D	48-57	tumor necrosis factor	Rattus norvegicus	24-33
15211579-11	2004	These results show that TNF-alpha inhibition of vitamin D-action includes stable integration of p65 in the VDR transcription complex.	Vitamin D	48-57	synaptotagmin 1	Rattus norvegicus	96-99
15323258-9	2004	Treatment with vitamin D pharmaceuticals was often limited by hyperphosphataemia, low PTH or hypercalinemia.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	86-89
15070901-6	2004	The up-regulation of DC-SIGN on THP-1 cells resembles its inducible expression on monocytes and macrophages, where DC-SIGN expression is also induced by IL-4/IL-13 and negatively regulated by TNF-alpha, LPS, and vitamin D(3).	Vitamin D	212-221	CD209 molecule	Homo sapiens	21-28
15070901-6	2004	The up-regulation of DC-SIGN on THP-1 cells resembles its inducible expression on monocytes and macrophages, where DC-SIGN expression is also induced by IL-4/IL-13 and negatively regulated by TNF-alpha, LPS, and vitamin D(3).	Vitamin D	212-221	CD209 molecule	Homo sapiens	115-122
15070901-6	2004	The up-regulation of DC-SIGN on THP-1 cells resembles its inducible expression on monocytes and macrophages, where DC-SIGN expression is also induced by IL-4/IL-13 and negatively regulated by TNF-alpha, LPS, and vitamin D(3).	Vitamin D	212-221	interleukin 4	Homo sapiens	153-157
15070901-6	2004	The up-regulation of DC-SIGN on THP-1 cells resembles its inducible expression on monocytes and macrophages, where DC-SIGN expression is also induced by IL-4/IL-13 and negatively regulated by TNF-alpha, LPS, and vitamin D(3).	Vitamin D	212-221	interleukin 13	Homo sapiens	158-163
15260882-13	2004	CONCLUSION: The highest AI for vitamin D brought summertime 25(OH)D to &gt;40 nmol/L, lowered PTH, and its use was associated with improved wellbeing.	Vitamin D	31-40	parathyroid hormone	Homo sapiens	94-97
15218361-0	2004	Growth and EGFR regulation in breast cancer cells by vitamin D and retinoid compounds.	Vitamin D	53-62	epidermal growth factor receptor	Homo sapiens	11-15
15218361-6	2004	Transfection of an EGFR promoter containing reporter plasmid demonstrated vitamin D induced changes in reporter gene activity that paralleled the changes observed in EGFR mRNA and protein.	Vitamin D	74-83	epidermal growth factor receptor	Homo sapiens	19-23
15218361-6	2004	Transfection of an EGFR promoter containing reporter plasmid demonstrated vitamin D induced changes in reporter gene activity that paralleled the changes observed in EGFR mRNA and protein.	Vitamin D	74-83	epidermal growth factor receptor	Homo sapiens	166-170
15218361-7	2004	Electrophoretic mobility shift assays using a putative vitamin D response element within this region of the EGFR promoter demonstrated specific VDR binding.	Vitamin D	55-64	epidermal growth factor receptor	Homo sapiens	108-112
15218361-8	2004	These results indicate that the vitamin D effect on EGFR expression in breast cancer cells has a transcriptional component likely mediated through a vitamin D responsive promoter sequence.	Vitamin D	32-41	epidermal growth factor receptor	Homo sapiens	52-56
15218361-8	2004	These results indicate that the vitamin D effect on EGFR expression in breast cancer cells has a transcriptional component likely mediated through a vitamin D responsive promoter sequence.	Vitamin D	149-158	epidermal growth factor receptor	Homo sapiens	52-56
15218361-9	2004	They also suggest that growth inhibition and EGFR down-regulation by vitamin D and retinoids may be related events in some breast cancer cells, but not in all.	Vitamin D	69-78	epidermal growth factor receptor	Homo sapiens	45-49
15178414-10	2004	Western blot analysis showed that the expression of androgen receptor (AR) protein was consistent with vitamin D(3) regulation of FACL3/ACS3 expression.	Vitamin D	103-112	androgen receptor	Homo sapiens	52-69
15178414-10	2004	Western blot analysis showed that the expression of androgen receptor (AR) protein was consistent with vitamin D(3) regulation of FACL3/ACS3 expression.	Vitamin D	103-112	androgen receptor	Homo sapiens	71-73
15178414-11	2004	Taken together, the data suggest that the upregulation of FACL3/ACS3 expression by vitamin D(3) is through an androgen/AR-mediated pathway and might be one of the contributions of the vitamin D(3) antiproliferative effect in prostate cancer LNCaP cells.	Vitamin D	83-92	androgen receptor	Homo sapiens	119-121
15178414-11	2004	Taken together, the data suggest that the upregulation of FACL3/ACS3 expression by vitamin D(3) is through an androgen/AR-mediated pathway and might be one of the contributions of the vitamin D(3) antiproliferative effect in prostate cancer LNCaP cells.	Vitamin D	184-193	androgen receptor	Homo sapiens	119-121
15125786-3	2004	INTRODUCTION: The multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, or vitamin D binding protein (DBP), has two functions with relation to bone tissue: it is the major carrier protein of vitamin D in the circulation, and deglycosylation converts it into a very potent macrophage- and osteoclast-activating factor (Gc-MAF).	Vitamin D	109-118	D-box binding PAR bZIP transcription factor	Homo sapiens	136-139
15186723-5	2004	PTH and vitamin D(3) induced high levels of expression of two key markers of bone formation: osteocalcin and alkaline phosphatase by MSCs.	Vitamin D	8-17	bone gamma-carboxyglutamate protein	Homo sapiens	93-104
15186723-6	2004	BMP-6 but not BMP-4 increased osteocalcin expression induced by PTH and vitamin D(3).	Vitamin D	72-81	bone morphogenetic protein 6	Homo sapiens	0-5
15186723-6	2004	BMP-6 but not BMP-4 increased osteocalcin expression induced by PTH and vitamin D(3).	Vitamin D	72-81	bone gamma-carboxyglutamate protein	Homo sapiens	30-41
15225764-1	2004	CYP27B1 (25-hydroxyvitamin D(3)-1alpha-hydroxylase) catalyzes the metabolization of 25-hydroxyvitamin D(3) to 1,25(OH)(2)D(3) the most active natural Vitamin D metabolite.	Vitamin D	150-159	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	9-50
15225794-1	2004	The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3).	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	65-69
15225761-1	2004	The enzyme 25-hydroxyvitamin D 1-hydroxylase (CYP27B1) is the rate limiting enzyme in the two-step activation process of Vitamin D to its active form 1,25-dihydroxyvitamin D (1,25D) and is located in the mitochondrial fraction of the proximal tubular cells of the kidney.	Vitamin D	121-130	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	46-53
15225761-2	2004	More recently CYP27B1 activity and expression have also been identified in a number of non-renal cells, which is suggestive of new, previously unidentified roles for Vitamin D in the human body.	Vitamin D	166-175	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	14-21
15225764-1	2004	CYP27B1 (25-hydroxyvitamin D(3)-1alpha-hydroxylase) catalyzes the metabolization of 25-hydroxyvitamin D(3) to 1,25(OH)(2)D(3) the most active natural Vitamin D metabolite.	Vitamin D	150-159	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-7
15225794-1	2004	The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3).	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	139-146
15225794-1	2004	The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3).	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	148-160
15225767-1	2004	Seventeen missense mutations of 25-hydroxyvitamin D(3) 1alpha-hydroxylase (CYP27B1) that cause Vitamin D-dependent rickets type I (VDDR-I) have been identified.	Vitamin D	95-104	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	75-82
15225829-5	2004	At early stages of renal failure, vitamin D therapy efficiently counteracts uremia- and high phosphorus-induced hyperplasia by inhibiting the increases in parathyroid-TGFalpha/EGFR co-expression.	Vitamin D	34-43	epidermal growth factor receptor	Homo sapiens	176-180
15225808-6	2004	Further, pretreatment of cultured VSMC with the Vitamin D non-calcemic analog JK 1624 F2-2 (JKF) increased ERalpha mRNA (100-200%) but decreased ERbeta mRNA (30-40%) expression as measured by real time PCR.	Vitamin D	48-57	estrogen receptor 1	Homo sapiens	107-114
15225801-1	2004	Calcitriol, the hormonal form of Vitamin D, potentiates the activity of some agents of the anti-cancer immune system including tumor necrosis factor-alpha (TNF-alpha).	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	127-154
15225801-1	2004	Calcitriol, the hormonal form of Vitamin D, potentiates the activity of some agents of the anti-cancer immune system including tumor necrosis factor-alpha (TNF-alpha).	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	156-165
15225804-4	2004	Additionally, modulation of cell proliferation by calpain inhibitors, as well as regulation of mRNA expression of VDR, 1alpha-OHase, and 24-OHase genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR, respectively.	Vitamin D	155-164	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	119-131
15225829-6	2004	In established hyperparathyroidism, characterized by highly enhanced-TGFalpha/EGFR co-expression, vitamin D therapy arrests growth by suppressing EGFR-growth signals from the plasma membrane and nuclear EGFR actions as a transactivator of the cyclin D1 gene, an important contributor to parathyroid hyperplasia in humans.	Vitamin D	98-107	epidermal growth factor receptor	Homo sapiens	78-82
15225829-6	2004	In established hyperparathyroidism, characterized by highly enhanced-TGFalpha/EGFR co-expression, vitamin D therapy arrests growth by suppressing EGFR-growth signals from the plasma membrane and nuclear EGFR actions as a transactivator of the cyclin D1 gene, an important contributor to parathyroid hyperplasia in humans.	Vitamin D	98-107	epidermal growth factor receptor	Homo sapiens	146-150
15225829-6	2004	In established hyperparathyroidism, characterized by highly enhanced-TGFalpha/EGFR co-expression, vitamin D therapy arrests growth by suppressing EGFR-growth signals from the plasma membrane and nuclear EGFR actions as a transactivator of the cyclin D1 gene, an important contributor to parathyroid hyperplasia in humans.	Vitamin D	98-107	epidermal growth factor receptor	Homo sapiens	146-150
15934135-2	2004	The mapped negative vitamin D response element (1alphanVDRE) in the human 1alpha(OH)ase gene promoter (around 530 bp) was distinct from those of the reported DR3-like nVDREs, composed of two E-box-like motifs.	Vitamin D	20-29	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	74-87
15005841-10	2004	In contrast, p values (0.003-0.096 by ANOVA) suggestive of an interaction between IL-6 -174 genotypes and years since menopause, estrogen status, dietary calcium, and vitamin D intake were observed in women (n = 819).	Vitamin D	167-176	interleukin 6	Homo sapiens	82-86
15183687-11	2004	Dex or BMP-2 treatment alone did not affect the basic osteocalcin levels, but in combination with vitamin D, BMP-2 increased the osteocalcin production, while Dex treatment completely suppressed osteocalcin production.	Vitamin D	98-107	bone gamma-carboxyglutamate protein	Homo sapiens	129-140
15070914-9	2004	Serum PTH is a predictor of time to first fall in the frail elderly independent of vitamin D status and measures of general health.	Vitamin D	83-92	parathyroid hormone	Homo sapiens	6-9
15183687-11	2004	Dex or BMP-2 treatment alone did not affect the basic osteocalcin levels, but in combination with vitamin D, BMP-2 increased the osteocalcin production, while Dex treatment completely suppressed osteocalcin production.	Vitamin D	98-107	bone gamma-carboxyglutamate protein	Homo sapiens	129-140
15214747-0	2004	The effect of vitamin D3 on CD34 progenitor cells in vitamin D deficiency rickets.	Vitamin D	14-23	CD34 molecule	Homo sapiens	28-32
15528944-0	2004	Intravenous vitamin D therapy reduces PTH-(1-84)/large C fragments ratio in chronic hemodialysis patients.	Vitamin D	12-21	parathyroid hormone	Homo sapiens	38-41
14758446-8	2004	Higher IL1 expression was detected in islets of vitamin D-deficient mice and their peritoneal macrophages had an aberrant cytokine profile (low IL1 and IL6, high IL15).	Vitamin D	48-57	interleukin 6	Mus musculus	152-155
15084353-11	2004	However, only in female-derived cells were ERalpha and ERbeta upregulated by pretreatment with Vitamin D analogs.	Vitamin D	95-104	estrogen receptor 1	Homo sapiens	43-50
15576951-4	2004	Hypercalcemia, uncontrollable hyperphosphatemia, low ALP, and low PTH might impair the vitamin D introduction.	Vitamin D	87-96	parathyroid hormone	Homo sapiens	66-69
15576961-1	2004	Adequate intakes of calcium and vitamin D are necessary to prevent vitamin D deficiency or increase of plasma parathyroid hormone (PTH) level caused by vitamin D insufficiency.	Vitamin D	32-41	parathyroid hormone	Homo sapiens	110-129
16819011-10	2004	Vitamin D insufficiency was seen among 14.5% of those participating according to traditional definition, but 50% were below [25(OH)D] of 45 nmol/l where negative correlation between [25(OH)D] and PTH became statistically significant.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	196-199
14712498-0	2004	Effect of vitamin D analog (1alpha hydroxy D5) immunoconjugated to Her-2 antibody on breast cancer.	Vitamin D	10-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-72
14871833-11	2004	In the hormone-independent and highly malignant Nb2-SFJCD1 subline, the constitutive expression of HRPAP20 was markedly reduced by exposure of the cells to dietary differentiating agents (butyrate, retinoic acid, and vitamin D(3)).	Vitamin D	217-226	NADH:ubiquinone oxidoreductase complex assembly factor 4	Rattus norvegicus	99-106
14646396-1	2004	OBJECTIVES: To compare the effects of vitamin D analogs versus calcitriol on serum levels of Ca, P and parathyroid hormone (PTH).	Vitamin D	38-47	parathyroid hormone	Rattus norvegicus	124-127
14643635-0	2004	Mycobacterium bovis infection of vitamin D-deficient NOS2-/- mice.	Vitamin D	33-42	nitric oxide synthase 2, inducible	Mus musculus	53-57
14643635-8	2004	However, effects of vitamin D on colonization, but not lesion area, were more pronounced in NOS2(+/+) mice than in NOS2(-/-) mice.	Vitamin D	20-29	nitric oxide synthase 2, inducible	Mus musculus	92-96
15528944-10	2004	CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy.	Vitamin D	306-315	parathyroid hormone	Homo sapiens	16-19
15528944-10	2004	CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy.	Vitamin D	306-315	parathyroid hormone	Homo sapiens	35-38
15528944-10	2004	CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy.	Vitamin D	306-315	parathyroid hormone	Homo sapiens	35-38
15528944-10	2004	CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy.	Vitamin D	306-315	parathyroid hormone	Homo sapiens	35-38
15033750-1	2003	Calcitriol, the hormonal form of vitamin D, inhibited caspase-3-like activation in HaCaT keratinocytes exposed to hyperosmotic and oxidative stresses, heat shock, and the inflammatory cytokine TNF.	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	193-196
14730505-2	2004	Impaired production of 1,25-dihydroxyvitamin D (calcitriol), the hormonal form of vitamin D, is a major contributor to the generation and maintenance of parathyroid hyperplasia and increased synthesis and secretion of PTH.	Vitamin D	37-46	parathyroid hormone	Homo sapiens	218-221
14592784-0	2003	PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight.	Vitamin D	119-128	parathyroid hormone	Homo sapiens	0-3
12960019-2	2003	To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR).	Vitamin D	38-47	bone gamma-carboxyglutamate protein	Rattus norvegicus	173-184
14531785-2	2003	The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH).	Vitamin D	17-26	parathyroid hormone	Homo sapiens	166-185
14531785-2	2003	The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH).	Vitamin D	17-26	parathyroid hormone	Homo sapiens	187-190
14671148-12	2003	Pegvisomant-induced normalization of serum IGF-I results in a decrease in markers of bone and soft tissue turnover to levels observed in age-matched controls, and these changes are accompanied by an increase in PTH and a decrease in 1,25-(OH)(2) vit D.	Vitamin D	246-251	insulin like growth factor 1	Homo sapiens	43-48
14531785-2	2003	The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH).	Vitamin D	80-89	parathyroid hormone	Homo sapiens	166-185
14531785-2	2003	The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH).	Vitamin D	80-89	parathyroid hormone	Homo sapiens	187-190
14531785-6	2003	The actions of active vitamin D sterols to augment intestinal absorption of both calcium and phosphorus, the effect to reduce levels of PTH, and to be a factor contributing to the rising incidence of low bone turnover (adynamic bone) are discussed.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	136-139
14592785-3	2003	Increased synthesis or intake of vitamin D can be expected to down-regulate parathyroid hormone (PTH), and to increase autocrine synthesis of its active metabolite calcitriol in certain tissues; these effects, in turn, may impact cancer risk, vascular health, immune regulation, and bone density through a variety of mechanisms.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	76-95
14592785-3	2003	Increased synthesis or intake of vitamin D can be expected to down-regulate parathyroid hormone (PTH), and to increase autocrine synthesis of its active metabolite calcitriol in certain tissues; these effects, in turn, may impact cancer risk, vascular health, immune regulation, and bone density through a variety of mechanisms.	Vitamin D	33-42	parathyroid hormone	Homo sapiens	97-100
14592785-8	2003	An overview suggests that a vegan diet supplemented with high-dose vitamin D should increase both systemic and autocrine calcitriol production while suppressing PTH secretion, and thus should represent a highly effective way to achieve the wide-ranging health protection conferred by optimal UV exposure.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	161-164
14550285-3	2003	Such a study revealed that synergistic action of vitamin D(3) and retinoic acid (RA) had inherent ability to down-regulate TACO gene transcription in human macrophages.	Vitamin D	49-58	coronin 1A	Homo sapiens	123-127
14520722-9	2003	Osteocalcin was 59.9 and 57.8 microg/l during vitamin D and placebo treatment, respectively, PINP 574 and 565 microg/l, PICP 381 and 382 microg/l, and ICTP 11.5 and 11.1 microg/l, respectively (NS).	Vitamin D	46-55	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
14557432-10	2003	High-dose vitamin D slightly increased serum osteocalcin (P &lt; 0.05) and decreased carboxy terminal propeptide type-I collagen (P &lt; 0.05) but did not affect other bone turnover markers.	Vitamin D	10-19	bone gamma-carboxyglutamate protein	Homo sapiens	45-56
14507860-0	2003	Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma.	Vitamin D	0-9	tumor protein p53	Homo sapiens	29-32
14507860-12	2003	There was an increase in staining for p53 and p21 in areas associated with cell death in specimens treated with vitamin D analogues.	Vitamin D	112-121	tumor protein p53	Homo sapiens	38-41
14557432-13	2003	The fall in CRP and IL-6 was more pronounced with the high- than low-dose vitamin D (P &lt; 0.05).	Vitamin D	74-83	C-reactive protein	Homo sapiens	12-15
14557432-13	2003	The fall in CRP and IL-6 was more pronounced with the high- than low-dose vitamin D (P &lt; 0.05).	Vitamin D	74-83	interleukin 6	Homo sapiens	20-24
15012693-5	2003	To prevent hypercalcemia, non-calcium containing phosphorus binder (sevelamer hydrochloride) and vitamin D analogues, which suppress PTH secretion with minimum calcemic action, have been developed.	Vitamin D	97-106	parathyroid hormone	Homo sapiens	133-136
14666505-20	2003	The vitamin D dose should be proportional to PTH levels, with a larger dose given as a bolus (23 ug twice or three times per week).	Vitamin D	4-13	parathyroid hormone	Homo sapiens	45-48
12968673-7	2003	The gene encoding vitamin D-binding protein (DBP), a key factor for regulating calcium homeostasis through the vitamin D endocrine system, is a probable candidate for conferring susceptibility to osteoporosis.	Vitamin D	18-27	D-box binding PAR bZIP transcription factor	Homo sapiens	45-48
13679819-0	2003	Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.	Vitamin D	16-25	negative elongation factor complex member C/D, Th1l	Mus musculus	48-51
13679819-9	2003	RESULTS: Early treatment with vitamin D augmented allergen-induced T-cell proliferation along with T(H)2 cytokine (IL-4 and IL-13) and IgE production.	Vitamin D	30-39	interleukin 13	Mus musculus	124-129
14506957-0	2003	Treatment of myoblastic C2C12 cells with BMP-2 stimulates vitamin D-induced formation of osteoclasts.	Vitamin D	58-67	bone morphogenetic protein 2	Mus musculus	41-46
12800192-0	2003	Vitamin D enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive oxygen species and mitochondria.	Vitamin D	0-9	tumor necrosis factor	Homo sapiens	54-62
12800192-1	2003	Calcitriol, the hormonal form of vitamin D, potentiates the activity of some common anticancer drugs and agents of the anticancer immune system, including tumor necrosis factor alpha (TNFalpha).	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	155-182
12800192-1	2003	Calcitriol, the hormonal form of vitamin D, potentiates the activity of some common anticancer drugs and agents of the anticancer immune system, including tumor necrosis factor alpha (TNFalpha).	Vitamin D	33-42	tumor necrosis factor	Homo sapiens	184-192
12914530-0	2003	Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase- polymerase chain reaction.	Vitamin D	31-40	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	62-69
12898515-6	2003	In combination treatments, 9-cisRA rapidly stimulated osteocalcin mRNA synthesis induced by the different vitamin D(3) compounds.	Vitamin D	106-115	bone gamma-carboxyglutamate protein	Homo sapiens	54-65
12865334-6	2003	Bone marrow cells from IL-7-deficient [IL-7 knockout (KO)] mice showed a significant (P &lt; 0.05) increase in tartrate-resistant acid phosphatase(+) OCL numbers in cultures that were stimulated with vitamin D(3) (136 +/- 13.3%), bPTH (196 +/- 18.8%), or M-CSF and RANKL (160 +/- 7.2%).	Vitamin D	200-209	interleukin 7	Mus musculus	23-27
12865334-6	2003	Bone marrow cells from IL-7-deficient [IL-7 knockout (KO)] mice showed a significant (P &lt; 0.05) increase in tartrate-resistant acid phosphatase(+) OCL numbers in cultures that were stimulated with vitamin D(3) (136 +/- 13.3%), bPTH (196 +/- 18.8%), or M-CSF and RANKL (160 +/- 7.2%).	Vitamin D	200-209	interleukin 7	Mus musculus	39-43
12874827-0	2003	The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells.	Vitamin D	15-24	CD4 molecule	Homo sapiens	80-83
12874827-13	2003	Clearly CD4+ T cells can be direct targets of vitamin D.	Vitamin D	46-55	CD4 molecule	Homo sapiens	8-11
12874827-14	2003	The targets of vitamin D in CD4+ T cells depend on the state of activation and differentiation status of the cells.	Vitamin D	15-24	CD4 molecule	Homo sapiens	28-31
12815097-4	2003	Impaired protein endocytosis in PTC of ClC-5 KO mice was demonstrated by (i) a major decreased uptake of injected 125I-beta 2-microglobulin, but not of the fluid-phase tracer, FITC-dextran, (ii) reduced labeling of endosomes by injected peroxidase and for the endogenous megalin/cubilin ligands, vitamin D- and retinol-binding proteins, and (iii) urinary appearance of low-molecular-weight proteins and the selective cubilin ligand, transferrin.	Vitamin D	296-305	chloride channel, voltage-sensitive 5	Mus musculus	39-44
12753273-4	2003	METHODS: This has led to the development of vitamin D analogs that retain the suppressive action on PTH and parathyroid gland growth, but that have less calcemic and phosphatemic activity.	Vitamin D	44-53	parathyroid hormone	Homo sapiens	100-103
12837248-6	2003	Furthermore, overexpression of WSTF could restore the impaired recruitment of VDR to vitamin D regulated promoters in fibroblasts from Williams syndrome patients.	Vitamin D	85-94	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	31-35
12850281-4	2003	The human PTHrP gene contains a sequence element homologous to the negative vitamin D response element within the parathyroid hormone gene.	Vitamin D	76-85	parathyroid hormone	Homo sapiens	114-133
12753256-1	2003	1,25-dihydroxyvitamin D [1,25(OH)2D3], the hormonal form of vitamin D, controls serum levels of parathyroid hormone (PTH) and parathyroid hyperplasia.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	96-115
12753256-1	2003	1,25-dihydroxyvitamin D [1,25(OH)2D3], the hormonal form of vitamin D, controls serum levels of parathyroid hormone (PTH) and parathyroid hyperplasia.	Vitamin D	14-23	parathyroid hormone	Homo sapiens	117-120
12746335-6	2003	In tests with other vitamin D responsive elements, such as that from the rat osteocalcin gene, lampVDR showed little or no activity.	Vitamin D	20-29	bone gamma-carboxyglutamate protein	Rattus norvegicus	77-88
12761878-3	2003	The overlap between their activities may suggest that vitamin D exerts some of its actions by modulation of KGF activities in the skin.	Vitamin D	54-63	fibroblast growth factor 7	Homo sapiens	108-111
12789152-1	2003	Vitamin D-dependent rickets type I (VDDRI) represents an autosomal recessive hereditary defect in vitamin D metabolism.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-41
12771290-2	2003	Effective clinical management includes measures to control phosphorus retention and prevent hyperphosphataemia, to maintain serum calcium concentrations within the normal range and to prevent excess parathyroid hormone (PTH) secretion by the judicious use of vitamin D sterols.	Vitamin D	259-268	parathyroid hormone	Homo sapiens	199-218
12771291-4	2003	In the myelomonocytic cell line, active vitamin D(3) is known to activate the transcription of both p21 and p27, cyclin-dependent kinase inhibitors (CDKIs), regulating the transition from the G(1) to the S phase of the cell cycle, in a VDR-dependent manner.	Vitamin D	40-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-103
12730764-0	2003	Abnormalities of the PTH-vitamin D axis and bone turnover markers in children, adolescents and adults with cystic fibrosis: comparison with healthy controls.	Vitamin D	25-34	parathyroid hormone	Homo sapiens	21-24
12789152-1	2003	Vitamin D-dependent rickets type I (VDDRI) represents an autosomal recessive hereditary defect in vitamin D metabolism.	Vitamin D	98-107	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-41
12789152-2	2003	Patients with VDDRI have mutations of chromosome 12 that affect the gene for the enzyme 1-alpha-hydroxylase, resulting in decreased levels of 1,25(OH)(2) vitamin D.	Vitamin D	154-163	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	14-19
12727200-0	2003	Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.	Vitamin D	0-9	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	35-41
12727200-0	2003	Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.	Vitamin D	72-81	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	35-41
12727200-0	2003	Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.	Vitamin D	152-161	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	35-41
12812258-8	2003	The gradient may be a trace of the demic expansion of agriculture that began about 10,000 years ago, but it may also reflect the possibility that APOE*4 carriers are less likely to develop vitamin D deficiency.	Vitamin D	189-198	apolipoprotein E	Homo sapiens	146-152
12706526-0	2003	Vitamin D(3) up-regulating protein 1 (VDUP1) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species.	Vitamin D	0-9	thioredoxin interacting protein	Mus musculus	38-43
12720534-4	2003	The effects of vitamin D and other factors on CYP19 expression were analysed by semiquantitative RT-PCR.	Vitamin D	15-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	46-51
12720534-7	2003	Vitamin D, dexamethasone, 17beta-estradiol and testosterone increased transcript levels of CYP19, whereas interleukin-1beta or tumor necrosis factor alpha decreased them.	Vitamin D	0-9	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	91-96
12720534-10	2003	CONCLUSIONS: Our results suggested that vitamin D, testosterone, estrogens and glucocorticoids regulate CYP19 gene expression in human primary osteoblasts and the main promoter used appears to be promoter I.4.	Vitamin D	40-49	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	104-109
12616536-0	2003	Modulation of TNF-alpha expression in bone marrow macrophages: involvement of vitamin D response element.	Vitamin D	78-87	tumor necrosis factor	Rattus norvegicus	14-23
12697832-3	2003	In osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by the Runx2/Cbfa1 transcription factor and is stimulated in response to vitamin D(3) via the vitamin D(3) receptor complex.	Vitamin D	178-187	bone gamma-carboxyglutamate protein	Homo sapiens	58-69
12697832-3	2003	In osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by the Runx2/Cbfa1 transcription factor and is stimulated in response to vitamin D(3) via the vitamin D(3) receptor complex.	Vitamin D	178-187	bone gamma-carboxyglutamate protein	Homo sapiens	71-73
12697832-10	2003	On the basis of these results, we propose that p300 interacts with key transcriptional regulators of the OC gene and bridges distal and proximal OC promoter sequences to facilitate responsiveness to vitamin D(3).	Vitamin D	199-208	bone gamma-carboxyglutamate protein	Homo sapiens	105-107
12689675-1	2003	Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets.	Vitamin D	27-36	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	62-69
12689675-1	2003	Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets.	Vitamin D	27-36	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	71-83
12689675-1	2003	Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets.	Vitamin D	27-36	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	128-132
12692048-1	2003	BACKGROUND AND AIMS: Vitamin D deficiency is common in patients with small intestinal resection and may lead to secondary hypersecretion of parathyroid hormone (PTH), which in turn may result in increased bone turnover rate and loss of bone mineral.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	140-159
12692048-1	2003	BACKGROUND AND AIMS: Vitamin D deficiency is common in patients with small intestinal resection and may lead to secondary hypersecretion of parathyroid hormone (PTH), which in turn may result in increased bone turnover rate and loss of bone mineral.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	161-164
12692048-2	2003	The aims of this study were to investigate the prevalence of vitamin D deficiency, as assessed by low serum concentrations of 25-hydroxyvitamin D (25(OH)D) in patients with small intestinal resection and to explore the relation of 25(OH)D to PTH, markers of bone turnover rate, and bone mineral density (BMD) in these patients.	Vitamin D	61-70	parathyroid hormone	Homo sapiens	242-245
12692048-8	2003	Vitamin D deficiency (25(OH)D concentration &lt;/=8 ng/ml) was found in 38.1% of patients and was accompanied by raised concentrations of PTH and significantly increased markers of bone resorption (p&lt;0.05).	Vitamin D	0-9	parathyroid hormone	Homo sapiens	138-141
12759877-3	2003	Because vitamin D regulates CYP19 gene expression, we also tested for an interaction with a translation start site polymorphism in the vitamin D receptor (VDR) gene.	Vitamin D	8-17	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	28-33
12746631-0	2003	Association study of the vitamin D: 1alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population.	Vitamin D	25-34	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	56-65
12674324-1	2003	The treatment of choice for pseudo-vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)2D3.	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	65-69
12674324-1	2003	The treatment of choice for pseudo-vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)2D3.	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	139-146
12674324-1	2003	The treatment of choice for pseudo-vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)2D3.	Vitamin D	35-44	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	148-160
12616536-10	2003	Next, we searched for potential vitamin D response elements (VDREs) in the promoter region (1.2 kb) of the TNF-alpha gene, and identified six such sequences.	Vitamin D	32-41	tumor necrosis factor	Rattus norvegicus	107-116
12631365-1	2003	BACKGROUND: Management of secondary hyperparathyroidism has included the use of active vitamin D or vitamin D analogs for the suppression of parathyroid hormone (PTH) secretion.	Vitamin D	87-96	parathyroid hormone	Homo sapiens	141-160
12631365-1	2003	BACKGROUND: Management of secondary hyperparathyroidism has included the use of active vitamin D or vitamin D analogs for the suppression of parathyroid hormone (PTH) secretion.	Vitamin D	100-109	parathyroid hormone	Homo sapiens	141-160
18209441-1	2003	While the effects of vitamin D, one-alphahydroxycholecalciferol (alphacalcidol) administered intravenously on the serum levels of parathormone (PTH) and calcium in dialysis patients have been well studied in the past few years, no detailed studies were conducted in patients from this part of the world.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	144-147
12637645-0	2003	Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone.	Vitamin D	43-52	parathyroid hormone	Homo sapiens	74-93
12730772-0	2003	In a population study, can parathyroid hormone aid the definition of adequate vitamin D status?	Vitamin D	78-87	parathyroid hormone	Homo sapiens	27-46
12587107-1	2003	The vitamin D(3) trial was a repeated measures randomized clinical trial for secondary hyperparathyroidism in haemodialysis patients where the efficacy of the vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups over 12 weeks.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	215-234
12587107-1	2003	The vitamin D(3) trial was a repeated measures randomized clinical trial for secondary hyperparathyroidism in haemodialysis patients where the efficacy of the vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups over 12 weeks.	Vitamin D	159-168	parathyroid hormone	Homo sapiens	215-234
12612963-4	2003	To prevent hypercalcemia, non-calcium-containing phosphorus binders and vitamin D analogues, which suppress parathyroid hormone (PTH) secretion with minimum calcemic action, have been developed.	Vitamin D	72-81	parathyroid hormone	Homo sapiens	108-127
12612964-2	2003	Vitamin D analogues have been used successfully to reduce PTH levels, but increases in serum calcium, phosphorus, and calcium x phosphorus ion product levels may occur.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	58-61
12577303-6	2003	New insight has been obtained using this technology related to the physiological significance of the vitamin D binding protein (DBP), used to transport vitamin D metabolites, as well as the physiological significance of target proteins including 25-hydroxyvitamin D(3) 24-hydroxylase (24(OH)ase), 25-hydroxyvitamin D(3)-1 alpha-hydroxylase (1 alpha-(OH)ase), VDR, and osteopontin.	Vitamin D	101-110	D site albumin promoter binding protein	Mus musculus	128-131
12586749-0	2003	Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells.	Vitamin D	117-126	dynactin subunit 6	Homo sapiens	104-107
15775101-2	2003	Active vitamin D and these analogues influence the bone turnover in hemodialysis patients and recently we often encounter the patients whose bone turnover is not high in spite of high PTH level.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	184-187
12520521-1	2003	Recent findings have indicated that calbindin-D(28k), the first known target of vitamin D action, is present in osteoblasts and protects against TNF and glucocorticoid induced apoptosis of osteoblastic cells.	Vitamin D	80-89	tumor necrosis factor	Homo sapiens	145-148
12653342-9	2003	Treatment of calcium and phosphate disturbances, including vitamin D therapy, significantly reduces insulin resistance in uremia.	Vitamin D	59-68	insulin	Homo sapiens	100-107
12520541-6	2003	Biosynthesis of CaBP is fully and CaT1 function is approximately 90% vitamin D-dependent.	Vitamin D	69-78	S100 calcium binding protein G	Homo sapiens	16-20
12711002-0	2003	Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion.	Vitamin D	12-21	estrogen receptor 1	Homo sapiens	44-61
12520534-0	2003	Vitamin D regulation of the renin-angiotensin system.	Vitamin D	0-9	renin	Homo sapiens	28-33
12711004-7	2003	The observation that the phorbol ester TPA sensitizes the Vitamin D(3)-resistant variant to the effects of 1,25-(OH)(2)D(3) suggests an important role for phosphorylation in dictating sensitivity to Vitamin D(3)-mediated apoptosis.	Vitamin D	58-67	plasminogen activator, tissue type	Homo sapiens	39-42
12711004-7	2003	The observation that the phorbol ester TPA sensitizes the Vitamin D(3)-resistant variant to the effects of 1,25-(OH)(2)D(3) suggests an important role for phosphorylation in dictating sensitivity to Vitamin D(3)-mediated apoptosis.	Vitamin D	199-208	plasminogen activator, tissue type	Homo sapiens	39-42
12616439-1	2003	We have previously shown that patients with elevated levels of parathyroid hormone (PTH) after surgery for parathyroid adenoma have normal parathyroid and renal function but demonstrate signs of remineralization of cortical bone, decreased calcium absorption, and low levels of vitamin D.	Vitamin D	278-287	parathyroid hormone	Homo sapiens	63-82
12778858-1	2003	As the chronic kidney disease patient is being managed for PTH, calcium, phosphate, vitamin D, calcium x phosphate product and bone quality an accurate PTH measurement is essential.	Vitamin D	84-93	parathyroid hormone	Homo sapiens	152-155
12393416-3	2003	Vitamin D(3) also induced phosphorylation of Smad2/3 and monocytic differentiation; however the effects were indirect, dependent on its ability to induce expression of TGF-beta1.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	168-177
14763068-2	2003	Various active metabolites of vitamin D are used as oral treatment; however, in some patients, parathyroid hormone (PTH) is not ideally suppressed.	Vitamin D	30-39	parathyroid hormone	Homo sapiens	95-114
12507780-3	2003	Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-beta 1 levels from 230+/-21 pg/ml at baseline to 295+/-40 pg/ml 6 months later.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	61-100
12507780-6	2003	IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not reach significance.	Vitamin D	37-46	interleukin 2	Homo sapiens	0-4
12507780-7	2003	Vitamin D supplementation of MS patients for 6 months was associated with increased vitamin D status and serum TGF-beta 1.	Vitamin D	0-9	transforming growth factor beta 1	Homo sapiens	111-121
12778847-8	2003	The renal and bone PTH-R1 expression is upregulated in vitamin D deficient rats and by endotoxin, interleukin-2, dexamethasone, T3, and TGF beta.	Vitamin D	55-64	parathyroid hormone	Rattus norvegicus	19-22
12899517-0	2003	A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.	Vitamin D	8-17	immediate early response 3	Homo sapiens	50-55
12778851-13	2003	CONCLUSIONS: Healthy men with higher levels of vitamin D have higher levels of SBP and DBP.	Vitamin D	47-56	D-box binding PAR bZIP transcription factor	Homo sapiens	87-90
12548389-4	2003	We review results obtained from these three mouse models and present new data on endosomal acidification and vitamin D metabolism in ClC-5 knock-out (KO) mice.	Vitamin D	109-118	chloride channel, voltage-sensitive 5	Mus musculus	133-138
12899526-2	2003	There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the vitamin D 25-hydroxylase (25-OHase) and the 1alpha-hydroxylase (1alpha-OHase).	Vitamin D	90-99	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	169-181
12899521-1	2003	The 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) is responsible for producing the active form of vitamin D, 1alpha,25-dihydroxyvitamin D.	Vitamin D	14-23	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	24-36
12899535-1	2003	Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes.	Vitamin D	33-42	interleukin 6	Homo sapiens	141-154
12899537-5	2003	The phytoestrogen genistein was shown to regulate different cytochrome P450 enzymes, a family of proteins to which both of the vitamin D-metabolizing CYP27B1 (1alpha-hydroxylase) and CYP24 (24-hydroxylase) belong.	Vitamin D	127-136	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	150-157
12908448-7	2003	Evidence has also emerged that vitamin D compounds can also affect the growth-promoting pathways initiated by two important factors involved in breast cancer cell promotion; namely the insulin-like growth factor I (IGF-I) and oestrogen-receptor (ER) pathways.	Vitamin D	31-40	insulin like growth factor 1	Homo sapiens	185-213
12899521-11	2003	In conclusion, the differential tissue expression of 1alpha-OHase gene variants and the tissue-specific regulation profile open up a new paradigm in the understanding of the role of 25-hydroxyvitamin D3 1alpha-hydroxylase gene in the regulation of vitamin D physiology.	Vitamin D	192-201	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	53-65
12432570-1	2002	In the present study, we examined whether anti-CD40+IL-4-mediated B cell proliferation and immunoglobulin synthesis is affected by vitamin D (VD) and its low-hypercalcemic analogue EB1089 in Bcells from healthy donors.	Vitamin D	131-140	interleukin 4	Homo sapiens	52-56
12470639-4	2002	Six vitamin D responsive element (VDRE)-like sequences in the promoter region of the CYP3A4 gene were then individually tested for their ability to enhance transcription.	Vitamin D	4-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91
12468132-8	2002	This may suggests that widespread supplementation with calcium and vitamin D may be required in postmenopausal women for PTH suppression and preservation of bone mass.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	121-124
15775262-7	2002	The maintenance of normacalcemia and normophosphatemia are important for the arrival into the target zone of PTH using active vitamin D.	Vitamin D	126-135	parathyroid hormone	Homo sapiens	109-112
12498308-4	2002	Hormonal responsiveness was characterized by measuring the capacity of 1,25-dihydroxyvitamin D [1,25(OH)2D], the hormonal form of vitamin D, to increase mRNA levels of the intestinal 24-hydroxylase cytochrome P-450 (CYP24).	Vitamin D	85-94	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	198-214
12454321-9	2002	RESULTS: Vitamin D status was the sole determinant of circulating MMP9 (inversely) and an independent determinant of CRP (inversely).	Vitamin D	9-18	C-reactive protein	Homo sapiens	117-120
12466393-3	2002	Here we show coincident increased expression of the vitamin D activating enzyme 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-hydroxylase) and reduced expressions of the 1,25(OH)(2)D(3) catabolizing enzyme 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-hydroxylase) in the majority of investigated parathyroid adenomas and secondary hyperplastic glands.	Vitamin D	52-61	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	80-121
12466393-3	2002	Here we show coincident increased expression of the vitamin D activating enzyme 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-hydroxylase) and reduced expressions of the 1,25(OH)(2)D(3) catabolizing enzyme 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-hydroxylase) in the majority of investigated parathyroid adenomas and secondary hyperplastic glands.	Vitamin D	52-61	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	210-251
12454321-12	2002	DISCUSSION: Vitamin-D insufficiency is associated with increased circulating MMP2,9 and CRP, correctable by supplementation.	Vitamin D	12-21	C-reactive protein	Homo sapiens	77-91
12477579-1	2002	It is known that nursing-home patients with vitamin D insufficiency have elevated serum parathyroid hormone (PTH) as well as raised serum alkaline phosphatase (ALP).	Vitamin D	44-53	parathyroid hormone	Homo sapiens	88-107
12477579-1	2002	It is known that nursing-home patients with vitamin D insufficiency have elevated serum parathyroid hormone (PTH) as well as raised serum alkaline phosphatase (ALP).	Vitamin D	44-53	parathyroid hormone	Homo sapiens	109-112
12477579-1	2002	It is known that nursing-home patients with vitamin D insufficiency have elevated serum parathyroid hormone (PTH) as well as raised serum alkaline phosphatase (ALP).	Vitamin D	44-53	alkaline phosphatase, placental	Homo sapiens	138-158
12477579-1	2002	It is known that nursing-home patients with vitamin D insufficiency have elevated serum parathyroid hormone (PTH) as well as raised serum alkaline phosphatase (ALP).	Vitamin D	44-53	alkaline phosphatase, placental	Homo sapiens	160-163
11983707-2	2002	Here we report that stress-activated protein kinases p38 and JNK trans-activate nuclear steroid vitamin D receptor (VDR) gene and increase vitamin D(3)-dependent growth inhibition in human breast cancer cells.	Vitamin D	96-105	mitogen-activated protein kinase 8	Homo sapiens	61-64
12444900-2	2002	Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vitamin D receptor (VDR) is involved in regulation of the calcium homeostasis together with PTH.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	166-169
12514921-11	2002	The correlation analysis among dietary intake and immune status, showed a positive association among vitamin A intake and vitamin D with CD4+ (r = 0.35; p &lt; 0.01) and (r = 0.51; p &lt; 0.001), respectively.	Vitamin D	122-131	CD4 molecule	Homo sapiens	137-140
12514921-12	2002	In the multivariant analysis with dependent variable (CD4 count), only vitamin D remained in the model (F = 16.99; p &lt; 0.001), with an increase of 34 (CI 95%: 5.81-167.3) CD4+ (count/uL) with each microgram of vitamin D intake, adjusted by age, sex, energy and protein intake, and anti-retroviral drugs.	Vitamin D	71-80	CD4 molecule	Homo sapiens	54-57
12514921-12	2002	In the multivariant analysis with dependent variable (CD4 count), only vitamin D remained in the model (F = 16.99; p &lt; 0.001), with an increase of 34 (CI 95%: 5.81-167.3) CD4+ (count/uL) with each microgram of vitamin D intake, adjusted by age, sex, energy and protein intake, and anti-retroviral drugs.	Vitamin D	71-80	CD4 molecule	Homo sapiens	174-177
12408227-0	2002	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells.	Vitamin D	0-9	zinc ribbon domain containing 2	Homo sapiens	39-42
12408227-0	2002	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells.	Vitamin D	0-9	zinc ribbon domain containing 2	Homo sapiens	84-87
12234297-1	2002	BACKGROUND: Calcitriol, 1,25-(OH)(2)D(3) (1,25D), the most active metabolite of vitamin D, has been used in the treatment of secondary hyperparathyroidism (SH) because it controls parathyroid gland growth and suppresses parathyroid hormone (PTH) synthesis and secretion.	Vitamin D	80-89	parathyroid hormone	Rattus norvegicus	220-239
12234297-1	2002	BACKGROUND: Calcitriol, 1,25-(OH)(2)D(3) (1,25D), the most active metabolite of vitamin D, has been used in the treatment of secondary hyperparathyroidism (SH) because it controls parathyroid gland growth and suppresses parathyroid hormone (PTH) synthesis and secretion.	Vitamin D	80-89	parathyroid hormone	Rattus norvegicus	241-244
12181175-4	2002	nVDR was inversely related to the vitamin D-induced levels of CaT1 mRNA, CaBP mRNA, PMCA mRNA, and net CaTx, with the highest induction seen in BBe.	Vitamin D	34-43	S100 calcium binding protein G	Homo sapiens	73-77
12375736-4	2002	However, the induction of osteocalcin synthesis and alkaline phosphatase activity in response to vitamin D, two characteristics of the osteoblast phenotype, were significantly antagonized by IL-1beta over a similar dose range.	Vitamin D	97-106	interleukin 1 beta	Mus musculus	191-199
12187294-2	2002	However, this could possibly influence vitamin D 25-hydroxylation because this reaction is catalyzed in part by the mitochondrial cytochrome P-450, the enzyme responsible for the 27-hydroxylation of cholesterol.	Vitamin D	39-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	130-146
11983707-0	2002	The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition.	Vitamin D	53-62	mitogen-activated protein kinase 14	Homo sapiens	4-7
11983707-0	2002	The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition.	Vitamin D	53-62	mitogen-activated protein kinase 8	Homo sapiens	12-15
11983707-2	2002	Here we report that stress-activated protein kinases p38 and JNK trans-activate nuclear steroid vitamin D receptor (VDR) gene and increase vitamin D(3)-dependent growth inhibition in human breast cancer cells.	Vitamin D	96-105	mitogen-activated protein kinase 14	Homo sapiens	53-56
12445200-0	2002	The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3.	Vitamin D	4-13	involucrin	Homo sapiens	38-48
12445200-3	2002	Within the distal regulatory region of the involucrin promoter lies an AP-1 site and an element homologous to other vitamin D response elements.	Vitamin D	116-125	involucrin	Homo sapiens	43-53
12445200-8	2002	The vitamin D response element from the involucrin gene bound the vitamin D receptor and the retinoid X receptor, but not the retinoic acid receptor, in a specific manner.	Vitamin D	4-13	involucrin	Homo sapiens	40-50
12445200-9	2002	We conclude that the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression, but the vitamin D response element provides specificity for the 1,25-dihydroxyvitamin D3 response lacking at the AP-1 site.	Vitamin D	39-48	involucrin	Homo sapiens	73-83
12445200-9	2002	We conclude that the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression, but the vitamin D response element provides specificity for the 1,25-dihydroxyvitamin D3 response lacking at the AP-1 site.	Vitamin D	39-48	involucrin	Homo sapiens	169-179
12445200-9	2002	We conclude that the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression, but the vitamin D response element provides specificity for the 1,25-dihydroxyvitamin D3 response lacking at the AP-1 site.	Vitamin D	155-164	involucrin	Homo sapiens	73-83
12445200-9	2002	We conclude that the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression, but the vitamin D response element provides specificity for the 1,25-dihydroxyvitamin D3 response lacking at the AP-1 site.	Vitamin D	155-164	involucrin	Homo sapiens	169-179
12421875-5	2002	Levels are determined by skin exposure to ultraviolet light or, to a minor extent, nutritional uptake and by subsequent conversion of the precursor vitamin D to the active hormone by the cytochrome P450 hydroxylases CYP27A1, CYP27B1 (responsible for synthesis) and CYP24 (responsible for catabolism) in liver and kidney.	Vitamin D	148-157	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	216-223
12421875-5	2002	Levels are determined by skin exposure to ultraviolet light or, to a minor extent, nutritional uptake and by subsequent conversion of the precursor vitamin D to the active hormone by the cytochrome P450 hydroxylases CYP27A1, CYP27B1 (responsible for synthesis) and CYP24 (responsible for catabolism) in liver and kidney.	Vitamin D	148-157	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	225-232
12376803-2	2002	Several advances have been made in the understanding of the pathogenesis of secondary hyperparathyroidism, particularly the critical roles of calcium, phosphorus, and vitamin D in promoting excess parathyroid hormone (PTH) synthesis and secretion, and parathyroid gland hyperplasia in renal failure.	Vitamin D	167-176	parathyroid hormone	Homo sapiens	197-216
12227689-3	2002	Recently, selective vitamin D analogs specifically designed to suppress parathyroid hormone (PTH) without causing hypercalcemia or hyperphosphatemia have shown promise for the treatment of secondary hyperparathyroidism in uremia.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	72-91
12191572-3	2002	We report the up-regulation of icb-1 transcript levels in HL-60 promyelocytic leukemia cells during their in vitro differentiation induced by all-trans retinoic acid, vitamin D(3) or DMSO.	Vitamin D	167-176	thymocyte selection associated family member 2	Homo sapiens	31-36
12357732-2	2002	Vitamin D supplementation is necessary when the plasma level of 25-hydroxy-vitamin D is below 30 nmol/l (12 pg/l) in order to avoid any increase of the plasma parathyroid hormone level.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	159-178
12077733-2	2002	In patients with humoral hypercalcemia of malignancy (HHM), it has been reported that plasma parathyroid hormone-related protein (PTHrP) and cyclic adenosine monophosphate (cAMP) levels were elevated, while plasma PTH and active vitamin D(3) levels were suppressed.	Vitamin D	229-238	parathyroid hormone	Homo sapiens	130-133
12203199-3	2002	In recent decades, our understanding of the complex interactions between calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) has increased, resulting in a rational approach to therapy in which vitamin D analogs have become an essential component.	Vitamin D	203-212	parathyroid hormone	Homo sapiens	130-133
12203199-6	2002	The occurrence of significant hypercalcemia and hyperphosphatemia limiting their use has led to the development of alternative vitamin D analogs that effectively reduce PTH secretion without causing these complications.	Vitamin D	127-136	parathyroid hormone	Homo sapiens	169-172
12203203-3	2002	Effective medical strategies to reduce PTH secretion and PTH-mediated bone turnover in sHPT (eg, controlling hyperphosphatemia, normalizing serum calcium, and administering vitamin D analogs) has decreased the need for parathyroidectomy in recent years.	Vitamin D	173-182	parathyroid hormone	Homo sapiens	57-60
12132525-0	2002	Isolated adrenocorticotropin deficiency presenting with impaired renin-angiotensin-aldosterone system and suppressed parathyroid hormone-vitamin D axis.	Vitamin D	137-146	parathyroid hormone	Homo sapiens	117-136
12132525-2	2002	She presented impaired renin-angiotensin-aldosterone (R-A-A) system and suppressed parathyroid hormone (PTH)-vitamin D system.	Vitamin D	109-118	parathyroid hormone	Homo sapiens	83-102
12122105-0	2002	Regulation of renin expression and blood pressure by vitamin D(3).	Vitamin D	53-62	renin	Homo sapiens	14-19
11991950-1	2002	The fully active dihydroxylated metabolite of vitamin D(3) induces the expression of CYP3A4 and, to a lesser extent, CYP2B6 and CYP2C9 genes in normal differentiated primary human hepatocytes.	Vitamin D	46-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91
12203199-3	2002	In recent decades, our understanding of the complex interactions between calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) has increased, resulting in a rational approach to therapy in which vitamin D analogs have become an essential component.	Vitamin D	203-212	parathyroid hormone	Homo sapiens	109-128
12051678-6	2002	Competitive (3)H-25-OH-D(3) binding curves for native DBP and DBP-actin complex were almost identical, further suggesting that vitamin D sterol- and actin-binding activities by DBP might be largely independent of each other.	Vitamin D	127-136	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
12119479-10	2002	Significant correlations between serum IGF-1 concentrations and vitamin D concentrations were noted only at 6 months.	Vitamin D	64-73	insulin like growth factor 1	Homo sapiens	39-44
11893738-0	2002	Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription.	Vitamin D	79-88	bone gamma-carboxyglutamate protein	Rattus norvegicus	35-46
11893738-6	2002	Acetylation of H4 at the OC gene is selectively increased following vitamin D(3) enhancement of OC transcription, with the most prominent changes occurring in the region between the vitamin D(3) enhancer and basal promoter.	Vitamin D	68-77	bone gamma-carboxyglutamate protein	Rattus norvegicus	25-27
11893738-6	2002	Acetylation of H4 at the OC gene is selectively increased following vitamin D(3) enhancement of OC transcription, with the most prominent changes occurring in the region between the vitamin D(3) enhancer and basal promoter.	Vitamin D	68-77	bone gamma-carboxyglutamate protein	Rattus norvegicus	96-98
11893738-6	2002	Acetylation of H4 at the OC gene is selectively increased following vitamin D(3) enhancement of OC transcription, with the most prominent changes occurring in the region between the vitamin D(3) enhancer and basal promoter.	Vitamin D	182-191	bone gamma-carboxyglutamate protein	Rattus norvegicus	25-27
11893738-7	2002	Thus, our results suggest functional linkage of H3 and H4 acetylation in specific regions of the OC promoter to chromatin remodeling that accompanies tissue-specific transcriptional activation and vitamin D enhancement of OC gene expression.	Vitamin D	197-206	bone gamma-carboxyglutamate protein	Rattus norvegicus	97-99
11893738-7	2002	Thus, our results suggest functional linkage of H3 and H4 acetylation in specific regions of the OC promoter to chromatin remodeling that accompanies tissue-specific transcriptional activation and vitamin D enhancement of OC gene expression.	Vitamin D	197-206	bone gamma-carboxyglutamate protein	Rattus norvegicus	222-224
12218287-5	2002	All-trans-retinoic acid, dithranol and the p38 mitogen-activated protein (MAP) kinase inhibitor SB220025 displayed a strong inhibitory effect on SKALP expression while cyclosporin A, dexamethasone, the vitamin D(3) derivative calcipotriol and the p38 MAP kinase inhibitor SB203580 showed only moderate inhibition.	Vitamin D	202-211	mitogen-activated protein kinase 14	Homo sapiens	43-46
12046038-9	2002	Time-dependent PTH levels were associated directly with duration of dialysis therapy and use of vitamin D and phosphate and albumin levels, but inversely with age and ionized calcium and magnesium levels (but not glucose or HbA1c levels).	Vitamin D	96-105	parathyroid hormone	Homo sapiens	15-18
12051678-6	2002	Competitive (3)H-25-OH-D(3) binding curves for native DBP and DBP-actin complex were almost identical, further suggesting that vitamin D sterol- and actin-binding activities by DBP might be largely independent of each other.	Vitamin D	127-136	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
12016314-4	2002	Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine.	Vitamin D	28-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-73
15775355-2	2002	In addition to the classic stimuli of PTH secretion such as hypocalcemia and decreased production of active vitamin D, new mechanisms has been suggested.	Vitamin D	108-117	parathyroid hormone	Homo sapiens	38-41
12050214-4	2002	The polymorphic vitamin D-binding protein (DBP) greatly facilitates vitamin D actions, and DBP alleles differ regarding their affinity for 1,25(OH)(2) D(3).	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
12111243-0	2002	Regulation of the mouse Nas1 promoter by vitamin D and thyroid hormone.	Vitamin D	41-50	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	24-28
12111243-3	2002	Mutational analysis of the Nas1 promoter resulted in identification of a direct repeat 6-type vitamin-D-responsive element (DR6 VDRE) at -525 to -508 and an imperfect inverted repeat 0-type T(3)-responsive element (IR0 T(3)RE) at -436 to -425 which conferred 1,25-(OH)(2)D(3) and T(3) responsiveness, respectively.	Vitamin D	94-103	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	27-31
11934649-2	2002	The results of our previous animal studies have suggested that the therapeutic effect of active vitamin D on bone loss after estrogen deficiency can be dissociated at least partly from its effect of enhancing intestinal calcium absorption and suppressing parathyroid hormone (PTH) secretion.	Vitamin D	96-105	parathyroid hormone	Rattus norvegicus	255-274
11964167-1	2002	1alpha,25-Dihydroxyvitamin D3-mediated transcriptional control of the bone-specific osteocalcin (OC) gene requires the integration of regulatory signals at the vitamin D-responsive element (VDRE) and flanking tissue-specific sequences.	Vitamin D	19-28	bone gamma-carboxyglutamate protein	Rattus norvegicus	84-95
11964167-1	2002	1alpha,25-Dihydroxyvitamin D3-mediated transcriptional control of the bone-specific osteocalcin (OC) gene requires the integration of regulatory signals at the vitamin D-responsive element (VDRE) and flanking tissue-specific sequences.	Vitamin D	19-28	bone gamma-carboxyglutamate protein	Rattus norvegicus	97-99
11994336-13	2002	5), the seasonal changes in vitamin D metabolism in elderly women are closely associated with small changes in serum PTH, changes in bone resorption, and BMD.	Vitamin D	28-37	parathyroid hormone	Homo sapiens	117-120
12032488-8	2002	Vitamin D compounds are believed to increase calcium absorption by inducing a calcium channel (epithelial calcium transporter or calcium transporter-1 [CaT1]) on the luminal membrane, a calcium-binding protein (Calbindin D9k) in the cytosol, and a calcium pump (plasma membrane calcium adenosine triphosphatase-1 [PMCA1]) on the basolateral membrane.	Vitamin D	0-9	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	152-156
12032488-8	2002	Vitamin D compounds are believed to increase calcium absorption by inducing a calcium channel (epithelial calcium transporter or calcium transporter-1 [CaT1]) on the luminal membrane, a calcium-binding protein (Calbindin D9k) in the cytosol, and a calcium pump (plasma membrane calcium adenosine triphosphatase-1 [PMCA1]) on the basolateral membrane.	Vitamin D	0-9	ATPase plasma membrane Ca2+ transporting 1	Rattus norvegicus	314-319
12027147-7	2002	RESULTS: A significant difference was observed between the calcium-vitamin D (CaD) and the calcium (Ca) only groups for changes occurring during the 90 days of the study in PTH (-14.5+/-40% and +2.5+/-46%) (p=0.009) and 25(OH)D (+67+/-77% and +18+/-55%) (p&lt;0.001) circulating levels.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	173-176
11890700-0	2002	Localization of a negative vitamin D response sequence in the human growth hormone gene.	Vitamin D	27-36	growth hormone 1	Homo sapiens	68-82
11912261-1	2002	Treatment with vitamin D sterols can lower plasma parathyroid hormone (PTH) in many patients with secondary hyperparathyroidism due to end-stage renal disease, but hypercalcemia, hyperphosphatemia, or both often develop during treatment.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	50-69
11875645-3	2002	We determined the expression of bcl-xL mRNA by RT-PCR, and also determined the effect of vitamin D(3) (VD3) on bcl-xL mRNA expression in cultured normal human keratinocytes by RT-PCR, and the expression of Bcl-xL in psoriatic lesions before and after topical application of VD3.	Vitamin D	89-98	BCL2 like 1	Homo sapiens	111-117
11839571-0	2002	Vitamin D arrests thyroid carcinoma cell growth and induces p27 dephosphorylation and accumulation through PTEN/akt-dependent and -independent pathways.	Vitamin D	0-9	AKT serine/threonine kinase 1	Homo sapiens	112-115
12014835-5	2002	Reduced IGF-I signalling is involved in muscle atrophy and results from decreased muscle exercise, reduced growth hormone and insulin levels, reduced vitamin D, and treatment with drugs like corticosteroids, dexamethasone, and cyclosporin.	Vitamin D	150-159	insulin like growth factor 1	Homo sapiens	8-13
11801653-3	2002	It has been established that the fat-soluble vitamin D(3) metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and its nuclear receptor, the vitamin D receptor, play an important role in the immune system primarily through the transcriptional inhibition of cytokine genes that either are required for Th1 differentiation or are products of differentiated Th1 cells.	Vitamin D	45-54	negative elongation factor complex member C/D, Th1l	Mus musculus	304-307
11801653-3	2002	It has been established that the fat-soluble vitamin D(3) metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and its nuclear receptor, the vitamin D receptor, play an important role in the immune system primarily through the transcriptional inhibition of cytokine genes that either are required for Th1 differentiation or are products of differentiated Th1 cells.	Vitamin D	45-54	negative elongation factor complex member C/D, Th1l	Mus musculus	358-361
12362981-0	2002	Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells.	Vitamin D	20-29	mitogen-activated protein kinase 3	Homo sapiens	76-82
11799400-2	2002	Here we report the 2.3 A crystal structure of DBP in complex with 25-hydroxyvitamin D3, a vitamin D3 metabolite, which reveals the vitamin D-binding site in the N-terminal part of domain I.	Vitamin D	76-85	D-box binding PAR bZIP transcription factor	Homo sapiens	46-49
11684680-3	2002	An 800-bp human OC (hOC) promoter-luciferase construct exhibited strong basal and vitamin D-induced activity in OC-positive human prostate and osteosarcoma cell lines.	Vitamin D	82-91	bone gamma-carboxyglutamate protein	Homo sapiens	16-18
11684680-3	2002	An 800-bp human OC (hOC) promoter-luciferase construct exhibited strong basal and vitamin D-induced activity in OC-positive human prostate and osteosarcoma cell lines.	Vitamin D	82-91	bone gamma-carboxyglutamate protein	Homo sapiens	21-23
11668178-4	2002	Expression of both C/EBPbeta and C/EBPdelta increases from the growth to maturation developmental stages and, like the bone-specific osteocalcin (OC) gene, is also stimulated 3-6-fold by vitamin D(3), a regulator of osteoblast differentiation.	Vitamin D	187-196	CCAAT/enhancer binding protein delta	Rattus norvegicus	33-43
11668178-4	2002	Expression of both C/EBPbeta and C/EBPdelta increases from the growth to maturation developmental stages and, like the bone-specific osteocalcin (OC) gene, is also stimulated 3-6-fold by vitamin D(3), a regulator of osteoblast differentiation.	Vitamin D	187-196	bone gamma-carboxyglutamate protein	Rattus norvegicus	133-144
12362981-5	2002	On the other hand, inhibition of cytosolic phospholipase A2 accelerated the differentiation of HL-60 cells induced by either 1,25-D3 or by the vitamin D analogs suggesting possible existence of a feedback loop between extracellular-signal regulated kinases and phospholipase A2.	Vitamin D	143-152	phospholipase A2 group IB	Homo sapiens	43-59
12097357-12	2002	However, the PKC isoform involved is PKCzeta, and its activity is inhibited, providing a mechanism for differential autocrine regulation of the cell and events in the matrix by these two vitamin D(3) metabolites.	Vitamin D	187-196	protein kinase C alpha	Homo sapiens	13-16
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	bone gamma-carboxyglutamate protein	Homo sapiens	186-197
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	S100 calcium binding protein G	Homo sapiens	228-241
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	251-255
12112004-9	2002	The effect of vitamin D (D3) on Cbfa1 mRNA expression was influenced by the duration of treatment, being inhibitory after 1 h and having a stimulatory effect after 48 h. Time course experiments indicated a stimulatory effect of D3 on Cbfa1 mRNA levels (by 2.5-fold after 48 h; P &lt; 0.01).	Vitamin D	14-23	RUNX family transcription factor 2	Homo sapiens	32-37
12006701-5	2002	Two types of vitamin D-dependent hereditary rickets (VDDR) are known to be caused by mutations in the 1alpha(OH)ase and VDR genes.	Vitamin D	13-22	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	53-57
12006701-5	2002	Two types of vitamin D-dependent hereditary rickets (VDDR) are known to be caused by mutations in the 1alpha(OH)ase and VDR genes.	Vitamin D	13-22	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	102-115
11891855-2	2002	In osseous cells expressing OC, the promoter region contains two nuclease hypersensitive sites that encompass the elements that regulate basal tissue-specific and vitamin D-enhanced OC transcription.	Vitamin D	163-172	bone gamma-carboxyglutamate protein	Rattus norvegicus	28-30
11891855-2	2002	In osseous cells expressing OC, the promoter region contains two nuclease hypersensitive sites that encompass the elements that regulate basal tissue-specific and vitamin D-enhanced OC transcription.	Vitamin D	163-172	bone gamma-carboxyglutamate protein	Rattus norvegicus	182-184
12112004-9	2002	The effect of vitamin D (D3) on Cbfa1 mRNA expression was influenced by the duration of treatment, being inhibitory after 1 h and having a stimulatory effect after 48 h. Time course experiments indicated a stimulatory effect of D3 on Cbfa1 mRNA levels (by 2.5-fold after 48 h; P &lt; 0.01).	Vitamin D	14-23	RUNX family transcription factor 2	Homo sapiens	234-239
12112013-1	2002	Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)].	Vitamin D	240-249	parathyroid hormone	Homo sapiens	51-70
12386263-2	2002	Vitamin D levels decline in the early phase of renal failure, however, through a compensatory mechanism parathyroid hormone (PTH) stimulates the production of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), calcitriol) to return it to normal circulating concentrations.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	125-128
11738120-3	2001	The Vitamin D(3) Trial was a repeated-measures, randomized clinical trial for secondary hyperparathyroidism in hemodialysis patients in which the efficacy of vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups during dialysis over 12 weeks.	Vitamin D	4-13	parathyroid hormone	Homo sapiens	214-233
12386263-12	2002	1,25-dihydroxy-22-oxavitamin D(3) (22-oxacalcitriol, OCT) is a vitamin D analogue that could control serum PTH concentrations without deleterious effects on bone.	Vitamin D	21-30	parathyroid hormone	Homo sapiens	107-110
12545685-1	2002	PURPOSE: The study objective is to determine the effectiveness of a vitamin D analogue, 1 alpha-hydroxyvitamin D2 (1 alpha-OH-D2), in inhibiting retinoblastoma in a transgenic retinoblastoma model (LH beta-Tag mouse) and to evaluate its toxicity.	Vitamin D	68-77	luteinizing hormone beta	Mus musculus	198-205
11770806-14	2001	As well as nutritional support, the new and recent therapeutic options in our team were: firstly, to avoid high doses of activated vitamin D to control PTH, as high doses are able to induce both a risk of adynamic bone disease and a direct bone cartilage toxicity: secondly, to maintain normal hemoglobin level; and thirdly, to deliver a high dialysis dose (urea, creatinine clearance) based on an individually adapted prescription.	Vitamin D	131-140	parathyroid hormone	Homo sapiens	152-155
12805727-8	2001	The channel upregulates calcium entry, with intracellular transport mediated by the mobile, vitamin D-dependent buffer, calbindin D9K, which binds and transports more than 90% of the transcellular calcium flux.	Vitamin D	92-101	S100 calcium binding protein G	Homo sapiens	120-133
11738120-3	2001	The Vitamin D(3) Trial was a repeated-measures, randomized clinical trial for secondary hyperparathyroidism in hemodialysis patients in which the efficacy of vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups during dialysis over 12 weeks.	Vitamin D	158-167	parathyroid hormone	Homo sapiens	214-233
11750096-9	2001	Despite an enhanced tendency to accumulate in G(0)/G(1), p16(INK4A)-overexpressing cells were less sensitive to induction of differentiation with vitamin D(3) or ATRA than control cells.	Vitamin D	146-155	cyclin dependent kinase inhibitor 2A	Homo sapiens	57-60
11737215-1	2001	Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).	Vitamin D	38-47	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	74-80
11750096-9	2001	Despite an enhanced tendency to accumulate in G(0)/G(1), p16(INK4A)-overexpressing cells were less sensitive to induction of differentiation with vitamin D(3) or ATRA than control cells.	Vitamin D	146-155	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-66
11723248-2	2001	We demonstrate the vitamin D analog, 19-nor-1alpha,25-dihydroxy vitamin D2, is also an effective inducer of CYP3A4 in Caco-2 cells, but with half the potency of 1,25-D3.	Vitamin D	19-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
11846329-0	2001	Relationship between disease activity and serum levels of vitamin D metabolites and parathyroid hormone in ankylosing spondylitis.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	84-103
11760027-0	2001	A case of pseudohypoparathyroidism type la complicated with growth hormone deficiency: recovery of growth hormone secretion after vitamin D therapy.	Vitamin D	130-139	growth hormone 1	Homo sapiens	60-74
11673900-7	2001	A unique feature of the AR-LUX assay is that effects on modulation of active endogenous AR-levels are reliably reflected in the luciferase induction response, as exemplified by vitamin D, all-trans-retinoic acid, epigallocatechin gallate, and forskolin.	Vitamin D	177-186	androgen receptor	Homo sapiens	24-26
11595067-0	2001	Calcium-parathyroid hormone-vitamin D axis and metabolic bone disease in chronic viral liver disease.	Vitamin D	28-37	parathyroid hormone	Homo sapiens	0-27
11853285-4	2001	The active form of vitamin D benefits bone health by enhancing osteocalcin formation, in addition vitamin D has moderate antiresorption and suppression of PTH secretion.	Vitamin D	19-28	bone gamma-carboxyglutamate protein	Homo sapiens	63-74
11853285-4	2001	The active form of vitamin D benefits bone health by enhancing osteocalcin formation, in addition vitamin D has moderate antiresorption and suppression of PTH secretion.	Vitamin D	98-107	parathyroid hormone	Homo sapiens	155-158
11592788-9	2001	RESULTS: Vitamin D supplementation decreased VDR and Smad3 protein levels.	Vitamin D	9-18	SMAD family member 3	Rattus norvegicus	53-58
11592788-11	2001	Vitamin D-treated rats had a significant (P = 0.001) reduction in bioactive renal TGF-beta(1).	Vitamin D	0-9	transforming growth factor, beta 1	Rattus norvegicus	82-90
11592788-13	2001	CONCLUSION: Our results suggest that vitamin D has a significant effect in regulating levels of bioactive TGF-beta(1) and appears to affect aspects of the TGF-beta(1) signaling system.	Vitamin D	37-46	transforming growth factor, beta 1	Rattus norvegicus	106-117
11592788-13	2001	CONCLUSION: Our results suggest that vitamin D has a significant effect in regulating levels of bioactive TGF-beta(1) and appears to affect aspects of the TGF-beta(1) signaling system.	Vitamin D	37-46	transforming growth factor, beta 1	Rattus norvegicus	106-114
11502592-0	2001	Vitamin D reduces renal NaPi-2 in PTH-infused rats: complexity of vitamin D action on renal P(i) handling.	Vitamin D	0-9	solute carrier family 34 member 1	Rattus norvegicus	24-30
11502592-0	2001	Vitamin D reduces renal NaPi-2 in PTH-infused rats: complexity of vitamin D action on renal P(i) handling.	Vitamin D	0-9	parathyroid hormone	Rattus norvegicus	34-37
11402043-1	2001	We investigated intracellular mechanisms involved in the up-regulation of plasminogen activator inhibitor I (PAI-1) synthesis by human recombinant tumor necrosis factor-alpha (TNF) during monocyte differentiation of HL-60 cells triggered by the transforming growth factor-beta1/vitamin D(3) (TGF/D3) mixture.	Vitamin D	278-287	tumor necrosis factor	Homo sapiens	176-179
11795018-15	2001	Only one patient has developed an exaggerated PTH response that has been controlled with oral vitamin D.	Vitamin D	94-103	parathyroid hormone	Homo sapiens	46-49
11402043-0	2001	Inhibition of p70(S6) kinase during transforming growth factor-beta 1/vitamin D(3)-induced monocyte differentiation of HL-60 cells allows tumor necrosis factor-alpha to stimulate plasminogen activator inhibitor-1 synthesis.	Vitamin D	70-79	ubiquitin associated and SH3 domain containing B	Homo sapiens	14-69
11520426-0	2001	Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	130-149
11402043-0	2001	Inhibition of p70(S6) kinase during transforming growth factor-beta 1/vitamin D(3)-induced monocyte differentiation of HL-60 cells allows tumor necrosis factor-alpha to stimulate plasminogen activator inhibitor-1 synthesis.	Vitamin D	70-79	tumor necrosis factor	Homo sapiens	138-165
11402043-1	2001	We investigated intracellular mechanisms involved in the up-regulation of plasminogen activator inhibitor I (PAI-1) synthesis by human recombinant tumor necrosis factor-alpha (TNF) during monocyte differentiation of HL-60 cells triggered by the transforming growth factor-beta1/vitamin D(3) (TGF/D3) mixture.	Vitamin D	278-287	tumor necrosis factor	Homo sapiens	147-174
11297596-8	2001	Compared with calcium, supplementation with vitamin D(3) and calcium resulted in an increase in serum 25OHD(3) of 72% (P &lt; 0.01), a decrease in serum PTH of 17% (P = 0.04), a decrease in systolic blood pressure (SBP) of 9.3% (P = 0.02), and a decrease in heart rate of 5.4% (P = 0.02).	Vitamin D	44-53	parathyroid hormone	Homo sapiens	153-156
11470722-0	2001	Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	31-50
11470722-4	2001	OBJECTIVE: We studied the effect of vitamin D status on serum intact parathyroid hormone (iPTH) concentrations and bone metabolism in adolescents.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	69-88
11470825-0	2001	Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.	Vitamin D	0-9	cadherin 1	Homo sapiens	87-97
11597027-0	2001	Transforming growth factor-beta1 and basic fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in vitamin-D-activated pulp cells.	Vitamin D	124-133	transforming growth factor beta 1	Homo sapiens	0-32
11597027-0	2001	Transforming growth factor-beta1 and basic fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in vitamin-D-activated pulp cells.	Vitamin D	124-133	fibroblast growth factor 2	Homo sapiens	37-67
11393167-1	2001	Mammalian alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin.	Vitamin D	123-132	alpha fetoprotein	Homo sapiens	10-27
11393167-1	2001	Mammalian alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin.	Vitamin D	123-132	alpha fetoprotein	Homo sapiens	29-32
11281654-0	2001	BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway.	Vitamin D	37-46	BAG cochaperone 1	Homo sapiens	0-5
11281654-0	2001	BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway.	Vitamin D	37-46	nuclear factor kappa B subunit 1	Homo sapiens	6-9
11281654-4	2001	Therefore, we investigated the effect of the recently isolated BAG-1 p50 on the vitamin D pathway.	Vitamin D	80-89	BAG cochaperone 1	Homo sapiens	63-68
11281654-4	2001	Therefore, we investigated the effect of the recently isolated BAG-1 p50 on the vitamin D pathway.	Vitamin D	80-89	nuclear factor kappa B subunit 1	Homo sapiens	69-72
11281654-7	2001	These results suggest that BAG-1 p50 is a novel regulator of the vitamin D signaling pathway, and its overexpression may lead to cellular resistance to 1,25(OH)2D3 therapy.	Vitamin D	65-74	BAG cochaperone 1	Homo sapiens	27-32
11281654-7	2001	These results suggest that BAG-1 p50 is a novel regulator of the vitamin D signaling pathway, and its overexpression may lead to cellular resistance to 1,25(OH)2D3 therapy.	Vitamin D	65-74	nuclear factor kappa B subunit 1	Homo sapiens	33-36
11331958-0	2001	Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to differentiation of p53-deficient MG-63 osteosarcoma cells.	Vitamin D	37-46	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-33
11331958-0	2001	Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to differentiation of p53-deficient MG-63 osteosarcoma cells.	Vitamin D	37-46	tumor protein p53	Homo sapiens	94-97
11331958-4	2001	We demonstrated that the gene encoding p21 was not only a vitamin D(3) target gene but also a vitamin K(2) target gene in the cells and that their differentiation was well related to the transcriptional activation of the p21 gene.	Vitamin D	58-67	cyclin dependent kinase inhibitor 1A	Homo sapiens	39-42
11331958-4	2001	We demonstrated that the gene encoding p21 was not only a vitamin D(3) target gene but also a vitamin K(2) target gene in the cells and that their differentiation was well related to the transcriptional activation of the p21 gene.	Vitamin D	58-67	cyclin dependent kinase inhibitor 1A	Homo sapiens	221-224
11331958-6	2001	The transcriptional activation of p21 by vitamin D(3) or vitamin K(2) in p53-deficient osteosarcoma cells demonstrated the p53-independent role of p21 in human osseous differentiation.	Vitamin D	41-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	34-37
11331958-6	2001	The transcriptional activation of p21 by vitamin D(3) or vitamin K(2) in p53-deficient osteosarcoma cells demonstrated the p53-independent role of p21 in human osseous differentiation.	Vitamin D	41-50	tumor protein p53	Homo sapiens	73-76
11331275-7	2001	The phosphorylation and expression of Akt, a kinase regulating a second cell survival pathway, was also inhibited after treatment with vitamin D(3).	Vitamin D	135-144	thymoma viral proto-oncogene 1	Mus musculus	38-41
11331275-10	2001	We propose that vitamin D(3) induces apoptosis in SCC cells by a unique mechanism involving selective caspase-dependent MEK cleavage and up-regulation of MEKK-1.	Vitamin D	16-25	mitogen-activated protein kinase kinase kinase 1	Mus musculus	154-160
11416220-1	2001	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1alpha-hydroxylase [1alpha(OH)ase] enzyme.	Vitamin D	19-28	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	174-200
11416220-1	2001	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1alpha-hydroxylase [1alpha(OH)ase] enzyme.	Vitamin D	19-28	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	202-215
11416220-5	2001	These abnormalities are similar to those described in humans with the genetic disorder vitamin D dependent rickets type I [VDDR-I; also known as pseudovitamin D-deficiency rickets (PDDR)].	Vitamin D	87-96	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	145-179
11416220-5	2001	These abnormalities are similar to those described in humans with the genetic disorder vitamin D dependent rickets type I [VDDR-I; also known as pseudovitamin D-deficiency rickets (PDDR)].	Vitamin D	87-96	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	181-185
11278818-3	2001	We investigated the molecular mechanisms by which TGF-beta and vitamin D signaling pathways interact in the regulation of the human osteocalcin promoter.	Vitamin D	63-72	bone gamma-carboxyglutamate protein	Homo sapiens	132-143
11278818-4	2001	Synergistic activation of the osteocalcin gene promoter by TGF-beta and vitamin D was observed in transient transfection experiments.	Vitamin D	72-81	bone gamma-carboxyglutamate protein	Homo sapiens	30-41
11297596-11	2001	Pearson coefficients of correlation between the change in PTH and the change in SBP were 0.49 (P &lt; 0.01) for the vitamin D(3) plus calcium group and 0.23 (P &lt; 0.01) for the calcium group.	Vitamin D	116-125	parathyroid hormone	Homo sapiens	58-61
11441291-6	2001	It has been shown that certain vitamin D analogs differ in their intracellular metabolism, nongenomic actions, pharmacokinetics, interaction with the vitamin D binding protein (DBP) or the vitamin D receptor (VDR).	Vitamin D	31-40	D-box binding PAR bZIP transcription factor	Homo sapiens	177-180
11357939-1	2001	Transforming growth factor-beta1 is an important local regulator of bone metabolism, acting downstream of estrogen and cooperatively with vitamin D.	Vitamin D	138-147	transforming growth factor beta 1	Homo sapiens	0-32
11338230-3	2001	In view of non response to calcium and vitamin D3, a possible diagnosis of VDDR I (Vitamin D-dependent rickets) was made and he was treated with calcium and calcitriol.	Vitamin D	83-92	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	75-81
11179739-10	2001	However, the ability of these agents to suppress cPLA2 activation was abrogated by co-treatment with CB1093, suggesting a role for arachidonic acid release in the caspase-independent mechanism by which vitamin D analogs prevent the protective effects of IGF-I on breast cancer cell survival.	Vitamin D	202-211	insulin like growth factor 1	Homo sapiens	254-259
11238511-24	2001	Treatment with vitamin D(3) and calcium increased serum 25OHD and decreased serum PTH significantly; the effect was greater for lower baseline serum 25OHD.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	82-85
11179739-5	2001	Pretreatment of MCF-7 and Hs578T cells with the vitamin D analogs substantially potentiated the cytotoxic effects of TNFalpha.	Vitamin D	48-57	tumor necrosis factor	Homo sapiens	117-125
11179742-2	2001	PLC-gamma1 is induced by 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)) in normal keratinocytes via a DR6-type vitamin D responsive element.	Vitamin D	44-53	phospholipase C gamma 1	Homo sapiens	0-10
11179747-1	2001	Cytochromes P450c1 and P450c24 are regulated hydroxylase enzymes that direct the bioactivation and metabolic degradation of vitamin D.	Vitamin D	124-133	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	12-18
11179723-0	2001	Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene.	Vitamin D	55-64	bone gamma-carboxyglutamate protein	Rattus norvegicus	110-121
11179723-1	2001	The vitamin D response element in the bone tissue-specific osteocalcin gene has served as a prototype for understanding molecular mechanisms regulating physiologic responsiveness of vitamin D-dependent genes in bone cells.	Vitamin D	4-13	bone gamma-carboxyglutamate protein	Rattus norvegicus	59-70
11179723-1	2001	The vitamin D response element in the bone tissue-specific osteocalcin gene has served as a prototype for understanding molecular mechanisms regulating physiologic responsiveness of vitamin D-dependent genes in bone cells.	Vitamin D	182-191	bone gamma-carboxyglutamate protein	Rattus norvegicus	59-70
11179723-4	2001	We present evidence for molecular mechanisms regulating vitamin D-dependent mediated transcription of the osteocalcin gene that involve chromatin structure of the gene and nuclear architecture.	Vitamin D	56-65	bone gamma-carboxyglutamate protein	Rattus norvegicus	106-117
11545681-10	2001	Moreover, the increase in CaT1 mRNA expression preceded by several hours the vitamin D induction of calbindin D9K, a putative cytosolic calcium transport protein.	Vitamin D	77-86	S100 calcium binding protein G	Homo sapiens	100-113
11158863-6	2001	The nephrology community is still waiting for the advent of nonhypercalcemic and nonhyperphosphatemic vitamin D analogs with PTH suppressive activity equal to the parent compound calcitriol or its immediate precursor, alfacalcidol.	Vitamin D	102-111	parathyroid hormone	Homo sapiens	125-128
11707147-4	2001	Administration of PTH in combination with antiresorptive agents such as estrogen, calcitonin, vitamin D and bisphosphonates augments its effect.	Vitamin D	94-103	parathyroid hormone	Homo sapiens	18-21
11686044-0	2001	Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24).	Vitamin D	40-49	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	83-90
11231880-18	2001	Although this polymorphism has been shown to affect the activation of vitamin D-dependent transcription, the molecular basis of the association between this polymorphism and insulin resistance remains to be determined.	Vitamin D	70-79	insulin	Homo sapiens	174-181
11165041-10	2001	These results indicate that CB1093 potentiates responsiveness of breast cancer cells to TNFalpha and suggest that ceramide and/or cPLA(2) might be involved as downstream effectors in vitamin D-mediated caspase-independent cell death.	Vitamin D	183-192	tumor necrosis factor	Homo sapiens	88-96
11172626-18	2001	The expression of CYP27B was found to be influenced by vitamin D status and parathyroid hormone.	Vitamin D	55-64	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	18-24
10967105-4	2000	BAG1L, but not shorter non-nuclear isoforms of this protein (BAG1; BAG1M/Rap46), markedly enhanced, in a ligand-dependent manner, the ability of VDR to trans-activate reporter gene plasmids containing a vitamin D response element in transient transfection assays.	Vitamin D	203-212	BAG cochaperone 1	Homo sapiens	0-4
11135373-2	2001	Because steroid hormones and growth factors significantly influence growth and differentiation properties of osteoblasts, we addressed Cbfa1 as a target gene for regulation by dexamethasone (Dex), 1,25(OH)D(3) (vitamin D(3)), 17beta-estradiol, and transforming growth factor-beta1 (TGF-beta1).	Vitamin D	211-220	RUNX family transcription factor 2	Homo sapiens	135-140
11135373-2	2001	Because steroid hormones and growth factors significantly influence growth and differentiation properties of osteoblasts, we addressed Cbfa1 as a target gene for regulation by dexamethasone (Dex), 1,25(OH)D(3) (vitamin D(3)), 17beta-estradiol, and transforming growth factor-beta1 (TGF-beta1).	Vitamin D	211-220	transforming growth factor beta 1	Homo sapiens	248-280
11135373-2	2001	Because steroid hormones and growth factors significantly influence growth and differentiation properties of osteoblasts, we addressed Cbfa1 as a target gene for regulation by dexamethasone (Dex), 1,25(OH)D(3) (vitamin D(3)), 17beta-estradiol, and transforming growth factor-beta1 (TGF-beta1).	Vitamin D	211-220	transforming growth factor beta 1	Homo sapiens	282-291
11271790-1	2001	AIMS: To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones.	Vitamin D	216-225	parathyroid hormone	Homo sapiens	167-186
11271790-1	2001	AIMS: To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones.	Vitamin D	216-225	parathyroid hormone	Homo sapiens	188-191
11384862-1	2001	Vitamin D, parathyroid hormone (PTH), and parathyroid hormone-related peptide (PTHrP) are major regulators of calcium metabolism and vitamin D can also reduce the growth of normal cells and tumor cells.	Vitamin D	133-142	parathyroid hormone-like peptide	Mus musculus	42-77
11384862-1	2001	Vitamin D, parathyroid hormone (PTH), and parathyroid hormone-related peptide (PTHrP) are major regulators of calcium metabolism and vitamin D can also reduce the growth of normal cells and tumor cells.	Vitamin D	133-142	parathyroid hormone-like peptide	Mus musculus	79-84
11384862-5	2001	Gene transcription of PTHrP per se can also be downregulated by 1,25(OH)(2)D and by low calcemic vitamin D analogs.	Vitamin D	97-106	parathyroid hormone-like peptide	Mus musculus	22-27
11384862-8	2001	This decreases the growth-inhibitory efficacy of 1,25(OH)(2)D. Studies of the capacity of vitamin D to alter PTHrP production and action and of its anti-proliferative effects can, therefore, shed important light on basic mechanisms controlling these events, and may also have major implications for clinical medicine and therapeutics.	Vitamin D	90-99	parathyroid hormone-like peptide	Mus musculus	109-114
11384870-16	2001	Vitamin D appears to upregulate androgen receptor expression, whereas androgens seem to upregulate vitamin D receptor (VDR).	Vitamin D	0-9	androgen receptor	Homo sapiens	32-49
11208041-3	2001	Two of these hormones, parathyroid hormone (PTH) and calcitriol (the active form of vitamin D), interact in multiple tissues in the body to regulate the flux of calcium and phosphorus between extra- and intracellular compartments.	Vitamin D	84-93	parathyroid hormone	Homo sapiens	23-42
11085922-0	2000	All natural DR3-type vitamin D response elements show a similar functionality in vitro.	Vitamin D	21-30	TNF receptor superfamily member 25	Homo sapiens	12-15
11085922-1	2000	The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)].	Vitamin D	4-13	TNF receptor superfamily member 25	Homo sapiens	312-315
11031222-4	2000	In vitamin D(3)-differentiated U-937 cells, thrombin-stimulated platelets increased TF expression as measured by mRNA quantification, flow cytometry, and procoagulant activity.	Vitamin D	3-12	coagulation factor II, thrombin	Homo sapiens	44-52
10948206-8	2000	These data suggest that the hnRNPA2-related VDRE-BP2 is a dominant-negative regulator of vitamin D action.	Vitamin D	89-98	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	28-35
11073568-1	2000	Chronic renal failure causes decreased vitamin D production, which profoundly alters parathyroid hormone (PTH) metabolism, and calcium and phosphorus balance.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	85-104
10924511-9	2000	Experiments with human liver microsomes and recombinantly expressed CYP2D6 strongly indicate that the microsomal 25-hydroxylation of vitamin D(3) in human liver is catalyzed by an enzyme different from CYP2D6.	Vitamin D	133-142	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	68-74
10924511-9	2000	Experiments with human liver microsomes and recombinantly expressed CYP2D6 strongly indicate that the microsomal 25-hydroxylation of vitamin D(3) in human liver is catalyzed by an enzyme different from CYP2D6.	Vitamin D	133-142	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	202-208
11029604-7	2000	After ingestion of the large dose of the vitamin D, the patient group registered a significant (P&lt;0.0001) increase in 25(OH)D3 levels, their Ad-SOS values increased (P&lt;0.0001) nearly to the mean basal value of the control group, and PTH decreased significantly (P&lt;0.0001).	Vitamin D	41-50	xylosyltransferase 2	Homo sapiens	147-150
10940510-1	2000	Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein).	Vitamin D	91-100	alpha-N-acetylgalactosaminidase	Homo sapiens	6-37
11013342-6	2000	In particular, analysis of the CYP1alpha gene has identified mutations causing the inherited disorder vitamin D-dependent rickets type 1, also known as pseudo-vitamin D deficiency rickets.	Vitamin D	102-111	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	31-40
11013342-6	2000	In particular, analysis of the CYP1alpha gene has identified mutations causing the inherited disorder vitamin D-dependent rickets type 1, also known as pseudo-vitamin D deficiency rickets.	Vitamin D	159-168	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	31-40
11013342-10	2000	Collectively, these observations have raised important new questions concerning the role of 1alpha-OHase in vitamin D signalling at a local level.	Vitamin D	108-117	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	92-104
10940510-1	2000	Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein).	Vitamin D	91-100	alpha-N-acetylgalactosaminidase	Homo sapiens	39-47
11061498-5	2000	Our results suggest that coexistent vitamin D insufficiency can obscure the diagnosis of primary hyperparathyroidism and, when treated effectively, can result in substantial short-terms gains in BMD despite persistence of the inappropriate production of PTH.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	254-257
10934643-1	2000	The genes responsible for X-linked hypophosphatemic (XLH) vitamin D-resistant rickets and the murine homolog, hypophosphatemic mice (Hyp), were identified as PHEX and Phex (phosphate-regulating gene with homology to endopeptidases on the X chromosome), respectively.	Vitamin D	58-67	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	158-162
10976917-7	2000	Stable overexpression of IDBP-1 in wild-type cells enhanced vitamin D-directed responsiveness of endogenous vitamin D-24-hydroxylase, osteopontin, and osteocalcin genes by several-fold over that observed in cells transfected with an empty vector.	Vitamin D	60-69	bone gamma-carboxyglutamate protein	Homo sapiens	151-162
10922312-0	2000	Vitamin D deficiency is implicated in reduced serum albumin concentrations in patients with end-stage renal disease.	Vitamin D	0-9	albumin	Homo sapiens	52-59
10922312-6	2000	Furthermore, the effect of supplementation with active forms of vitamin D during 4 months of hemodialysis treatment on serum albumin concentrations was retrospectively evaluated in the low-D(3) group.	Vitamin D	64-73	albumin	Homo sapiens	125-132
10922312-10	2000	Supplementation with active forms of vitamin D significantly increased serum albumin concentrations in the low-D(3) group from 3.	Vitamin D	37-46	albumin	Homo sapiens	77-84
10922312-12	2000	These findings indicate that reductions in serum albumin concentrations may be attributed, at least in part, to vitamin D deficiency in patients with end-stage renal disease.	Vitamin D	112-121	albumin	Homo sapiens	49-56
10934643-1	2000	The genes responsible for X-linked hypophosphatemic (XLH) vitamin D-resistant rickets and the murine homolog, hypophosphatemic mice (Hyp), were identified as PHEX and Phex (phosphate-regulating gene with homology to endopeptidases on the X chromosome), respectively.	Vitamin D	58-67	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	167-171
10977006-14	2000	In a multivariate model, inadequate vitamin D intake, urban dwelling, veil wearing, and high parity in women were independent predictors of hypovitaminosis D. 25(OH)D was related inversely to PTH and free DPD whereas osteocalcin achieved only a weak positive correlation with 25(OH)D. In the absence of information regarding time spent outdoors, our results show that hypovitaminosis D is common among young Lebanese people and is related mostly to low vitamin D intake.	Vitamin D	453-462	bone gamma-carboxyglutamate protein	Homo sapiens	217-228
10896790-2	2000	Recent studies have reported diametrically opposing responses in the vitamin D regulation of the mouse vs the human and rat osteocalcin genes.	Vitamin D	69-78	bone gamma-carboxyglutamate protein	Rattus norvegicus	124-135
10873663-0	2000	Vitamin D induced up-regulation of keratinocyte growth factor (FGF-7/KGF) in MCF-7 human breast cancer cells.	Vitamin D	0-9	fibroblast growth factor 7	Homo sapiens	35-61
11019490-5	2000	The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion.	Vitamin D	61-70	POU class 1 homeobox 1	Rattus norvegicus	14-19
11019490-5	2000	The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion.	Vitamin D	61-70	parathyroid hormone	Rattus norvegicus	130-133
10873663-0	2000	Vitamin D induced up-regulation of keratinocyte growth factor (FGF-7/KGF) in MCF-7 human breast cancer cells.	Vitamin D	0-9	fibroblast growth factor 7	Homo sapiens	63-68
10873663-0	2000	Vitamin D induced up-regulation of keratinocyte growth factor (FGF-7/KGF) in MCF-7 human breast cancer cells.	Vitamin D	0-9	fibroblast growth factor 7	Homo sapiens	69-72
10873663-3	2000	To determine whether vitamin D may play a role in the expression of FGF-7, we investigated FGF-7 expression in human breast cancer cells treated with 1,25-dihydroxyvitamin D3, which inhibited the growth of the cells.	Vitamin D	21-30	fibroblast growth factor 7	Homo sapiens	68-73
10873663-4	2000	By means of cDNA microarray, RT-PCR, and Western blot analysis, we have shown an increase in expression of FGF-7 on both mRNA and protein levels after vitamin D exposure.	Vitamin D	151-160	fibroblast growth factor 7	Homo sapiens	107-112
10873663-5	2000	This is the first demonstration of vitamin D regulation of FGF-7 expression and its possible involvement in mediating growth and differentiation by vitamin D.	Vitamin D	35-44	fibroblast growth factor 7	Homo sapiens	59-64
10873663-5	2000	This is the first demonstration of vitamin D regulation of FGF-7 expression and its possible involvement in mediating growth and differentiation by vitamin D.	Vitamin D	148-157	fibroblast growth factor 7	Homo sapiens	59-64
11305809-5	2000	RESULTS: The main findings were: amelioration of 1,25(OH)2D3-induced hypercalcemia by 24,25(OH)2D3, and similar suppression of PTH by the two metabolites of vitamin D when administered alone or in combination.	Vitamin D	157-166	parathyroid hormone	Rattus norvegicus	127-130
10893342-2	2000	The inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) is produced in excess in these disorders and has been shown to decrease osteoblast transcriptional responsiveness to vitamin D and to inhibit the binding of the vitamin D receptor (VDR) and its nuclear partner the retinoid X receptor (RXR) to DNA.	Vitamin D	183-192	tumor necrosis factor	Rattus norvegicus	26-53
10893342-2	2000	The inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) is produced in excess in these disorders and has been shown to decrease osteoblast transcriptional responsiveness to vitamin D and to inhibit the binding of the vitamin D receptor (VDR) and its nuclear partner the retinoid X receptor (RXR) to DNA.	Vitamin D	183-192	tumor necrosis factor	Rattus norvegicus	55-64
10893342-3	2000	Previous studies have shown that a vitamin D (VDRE) or retinoid X DNA response element (RXRE) is sufficient to confer TNF-alpha inhibition of vitamin D or retinoid-stimulated transcription in the absence of known TNF-alpha-responsive DNA sequences.	Vitamin D	35-44	tumor necrosis factor	Rattus norvegicus	118-127
10893342-3	2000	Previous studies have shown that a vitamin D (VDRE) or retinoid X DNA response element (RXRE) is sufficient to confer TNF-alpha inhibition of vitamin D or retinoid-stimulated transcription in the absence of known TNF-alpha-responsive DNA sequences.	Vitamin D	142-151	tumor necrosis factor	Rattus norvegicus	118-127
10837301-0	2000	Vitamin D status: effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	29-48
10914987-6	2000	Administration of vitamin D metabolites constitutes the most promising form of prophylaxis and should be performed with monitoring of the PTH level to avoid adynamic bone disease.	Vitamin D	18-27	parathyroid hormone	Homo sapiens	138-141
10828302-6	2000	Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses.	Vitamin D	29-38	D-box binding PAR bZIP transcription factor	Homo sapiens	422-425
10872194-2	2000	Although successful control of the parathyroid hormone (PTH) levels was achieved by treatment with vitamin D pulse therapy, the lesion progressed, invaded the maxillary sinus, and caused severe eating and speech disabilities.	Vitamin D	99-108	parathyroid hormone	Homo sapiens	35-54
10872194-2	2000	Although successful control of the parathyroid hormone (PTH) levels was achieved by treatment with vitamin D pulse therapy, the lesion progressed, invaded the maxillary sinus, and caused severe eating and speech disabilities.	Vitamin D	99-108	parathyroid hormone	Homo sapiens	56-59
10965681-1	2000	INTRODUCTION: Factors implicated in the pathogenesis of insulin resistance in chronic renal failure are: uremic toxins, exercise tolerance, metabolic acidosis, secondary hyperparathyroidism, vitamin D deficiency.	Vitamin D	191-200	insulin	Homo sapiens	56-63
10720039-9	2000	Suboptimal vitamin D nutrition stimulates parathyroid adenoma growth by a mechanism unrelated to hypocalcemia or 1,25-dihydroxyvitamin D deficiency and reduces the calcemic response to PTH, so that a higher PTH level and more parathyroid cells are needed to raise the patient"s serum calcium to the level corresponding to the increased set-point that is characteristic of the disease.	Vitamin D	11-20	parathyroid hormone	Homo sapiens	185-188
10720039-9	2000	Suboptimal vitamin D nutrition stimulates parathyroid adenoma growth by a mechanism unrelated to hypocalcemia or 1,25-dihydroxyvitamin D deficiency and reduces the calcemic response to PTH, so that a higher PTH level and more parathyroid cells are needed to raise the patient"s serum calcium to the level corresponding to the increased set-point that is characteristic of the disease.	Vitamin D	11-20	parathyroid hormone	Homo sapiens	207-210
10783492-0	2000	Parathyroid hormone may be a cancer promoter - an explanation for the decrease in cancer risk associated with ultraviolet light, calcium, and vitamin D.	Vitamin D	142-151	parathyroid hormone	Homo sapiens	0-19
10783492-3	2000	UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	73-92
10783492-3	2000	UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	94-97
10783492-3	2000	UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	159-162
10890574-2	2000	The DBP found in the emydid family of turtles is unique in that it exhibits high-affinity binding of both vitamin D and thyroxine (D/TBP).	Vitamin D	106-115	D-box binding PAR bZIP transcription factor	Homo sapiens	4-7
10678941-4	2000	A library of 1,152 Brucella suis 1330 tagged mini-Tn5 Km2 mutants, in 12 pools, was screened for intracellular survival and multiplication in vitamin D(3)-differentiated THP1 cells.	Vitamin D	142-151	GLI family zinc finger 2	Homo sapiens	170-174
10750555-0	2000	Association of transforming growth factor beta1 genotype with therapeutic response to active vitamin D for postmenopausal osteoporosis.	Vitamin D	93-102	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	42-47
10750555-1	2000	Transforming growth factor beta (TGF-beta) is an important regulator of bone metabolism, its effects being intertwined with those of estrogen and vitamin D.	Vitamin D	146-155	transforming growth factor beta 1	Homo sapiens	0-31
10750555-1	2000	Transforming growth factor beta (TGF-beta) is an important regulator of bone metabolism, its effects being intertwined with those of estrogen and vitamin D.	Vitamin D	146-155	transforming growth factor beta 1	Homo sapiens	33-41
10750555-9	2000	These results suggest that TGF-beta1 genotype is associated with both the rate of bone loss and the response to active vitamin D treatment.	Vitamin D	119-128	transforming growth factor beta 1	Homo sapiens	27-36
10692108-7	2000	The decreased vitamin D receptor expression was accompanied by reduced vitamin D responsiveness (as assessed by 24-hydroxylase mRNA induction) in postconfluent, high calcium, and 12-O-tetradecanoyl phorbol 13-acetate treated keratinocytes but not with interferon-gamma treatment.	Vitamin D	14-23	interferon gamma	Homo sapiens	252-268
10965681-12	2000	VITAMIN D DEFICIENCY: Acute and chronic intravenous 1,25-Dihydroxycholecalciferol therapy corrects insulin resistance in dialysis patients, in absence of PTH suppression.	Vitamin D	0-9	insulin	Homo sapiens	99-106
10662728-4	2000	Vitamin D-deficient, thyroparathyrodectomized rats had lower serum and higher urinary calcium concentrations compared with control animals as well as lower serum PTH and calcitonin concentrations.	Vitamin D	0-9	parathyroid hormone	Rattus norvegicus	162-165
10692523-0	2000	Vitamin D metabolite requirements in dialysed children receiving recombinant human growth hormone.	Vitamin D	0-9	growth hormone 1	Homo sapiens	83-97
10692523-1	2000	BACKGROUND: The aim of the study was to assess the requirement of active vitamin D in dialysed children during treatment with recombinant human growth hormone (rhGH).	Vitamin D	73-82	growth hormone 1	Homo sapiens	144-158
10662728-6	2000	ClC-5 mRNA and protein expression increase near to control levels in vitamin D-deficient, thyroparathyroidectomized rats injected with PTH.	Vitamin D	69-78	parathyroid hormone	Rattus norvegicus	135-138
10640426-0	2000	Cell cycle arrest induced by the vitamin D(3) analog EB1089 in NCI-H929 myeloma cells is associated with induction of the cyclin-dependent kinase inhibitor p27.	Vitamin D	33-42	dynactin subunit 6	Homo sapiens	156-159
10620374-13	2000	Successful affinity labeling of recombinant domain I (1-203) of DBP with both reagents indicated that different areas of the same vitamin D-binding pocket (domain I) were labeled.	Vitamin D	130-139	D-box binding PAR bZIP transcription factor	Homo sapiens	64-67
10620374-1	2000	The multiple physiological properties of vitamin D-binding protein (DBP) include organ-specific transportation of vitamin D(3) and its metabolites, manifested by its ability to bind vitamin D sterols with high affinity.	Vitamin D	41-50	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71
10567209-6	1999	The purified vitamin D receptor binds to the vitamin D response elements of osteopontin and osteocalcin genes as a homodimer or as a heterodimer with the retinoid X receptor-alphaDeltaAB and we were able to purify these complexes in quantities sufficient for crystallization studies.	Vitamin D	13-22	bone gamma-carboxyglutamate protein	Homo sapiens	92-103
10620374-2	2000	In the present investigation we probed the vitamin D sterol-binding pocket of human DBP with affinity labeling analogs of 25-hydroxyvitamin D(3) ?25-OH-D(3) and 1, 25-dihydroxyvitamin D(3) ?1,25(OH)(2)D(3) containing bromoacetate alkylating probe at C-3 (A-ring), C-6 (triene), C-11 (C-ring), and C-19 (exocyclic methylene) of the parent sterol.	Vitamin D	43-52	D-box binding PAR bZIP transcription factor	Homo sapiens	84-87
11256894-8	2000	In summary, in this fairly vitamin D replete population with high calcium intake, PTH was negatively associated with total body BMD.	Vitamin D	27-36	parathyroid hormone	Homo sapiens	82-85
10659699-6	1999	Furthermore, 1alpha,25(OH)2-24-oxo-20-epi-D3 induces the conformation of the vitamin D receptor similar to that induced by its parent analog and is nearly as potent as its parent in inducing transactivation of a gene construct containing the human osteocalcin vitamin D-responsive element.	Vitamin D	77-86	bone gamma-carboxyglutamate protein	Homo sapiens	248-259
10566658-1	1999	Pseudovitamin D deficiency rickets (PDDR) is an autosomal recessive disorder caused by defect in the activation of vitamin D.	Vitamin D	6-15	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
10674019-0	1999	Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	29-34
10674019-4	1999	The aim of this study was to determine the relationship between inhibition of IGF-I responsiveness and induction of apoptosis by vitamin D analogues in breast cancer cells.	Vitamin D	129-138	insulin like growth factor 1	Homo sapiens	78-83
10674019-5	1999	Vitamin D analogues EB1089 and CB1093 inhibited autonomous and IGF-I-stimulated growth of MCF-7 and T47D cells and autonomous growth of IGF-I-insensitive Hs578T cells.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	63-68
10674019-5	1999	Vitamin D analogues EB1089 and CB1093 inhibited autonomous and IGF-I-stimulated growth of MCF-7 and T47D cells and autonomous growth of IGF-I-insensitive Hs578T cells.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	136-141
10674019-7	1999	Co-treatment with vitamin D analogues prevented the anti-apoptotic effects of IGF-I.	Vitamin D	18-27	insulin like growth factor 1	Homo sapiens	78-83
10674019-11	1999	Our findings suggest that vitamin D analogues inhibit IGF-I signalling pathways to promote apoptosis in breast cancer cells.	Vitamin D	26-35	insulin like growth factor 1	Homo sapiens	54-59
10566687-8	1999	Since low concentrations of PTH are frequently associated with adynamic bone disease, our findings may have significant implications for the treatment of renal osteodystrophy with calcium and/or biologically active vitamin D analogs.	Vitamin D	215-224	parathyroid hormone	Homo sapiens	28-31
10602348-17	1999	The depression of the vitamin D-PTH system seen among smokers may represent another potential mechanism for the deleterious effects of smoking on the skeleton, and may contribute to the reported risk of osteoporosis among smokers.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	32-35
10633456-0	1999	Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate.	Vitamin D	46-55	parathyroid hormone	Rattus norvegicus	18-37
10633464-1	1999	Calcitriol, the most active metabolite of vitamin D, controls parathyroid gland growth and suppresses the synthesis and secretion of parathyroid hormone (PTH).	Vitamin D	42-51	parathyroid hormone	Homo sapiens	133-152
10633464-6	1999	In some analogs the serum binding protein (DBP) plays a key role in determining the pharmacokinetics of the vitamin D compound.	Vitamin D	108-117	D-box binding PAR bZIP transcription factor	Homo sapiens	43-46
10571682-0	1999	Vitamin D receptor interactions with the rat parathyroid hormone gene: synergistic effects between two negative vitamin D response elements.	Vitamin D	112-121	parathyroid hormone	Rattus norvegicus	45-64
10571682-1	1999	Vitamin D response elements (VDREs) that are required for negative regulation of rat parathyroid hormone (rPTH) gene expression have been characterized.	Vitamin D	0-9	parathyroid hormone	Rattus norvegicus	85-104
10571682-1	1999	Vitamin D response elements (VDREs) that are required for negative regulation of rat parathyroid hormone (rPTH) gene expression have been characterized.	Vitamin D	0-9	parathyroid hormone	Rattus norvegicus	106-110
10523637-0	1999	Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.	Vitamin D	83-92	bone gamma-carboxyglutamate protein	Rattus norvegicus	35-46
10544252-3	1999	Transient transfection analysis and in vitro DNA binding studies identified two vitamin D-responsive elements (VDRE) in the human t-PA enhancer.	Vitamin D	80-89	plasminogen activator, tissue type	Homo sapiens	130-134
10485973-11	1999	Basal vitamin D status appeared to be a determinant of the degree of the PTH response in black women, with the peak PTH level being inversely correlated with levels of 25OHD.	Vitamin D	6-15	parathyroid hormone	Homo sapiens	73-76
10516141-6	1999	It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene.	Vitamin D	88-97	ATPase, class II, type 9B	Mus musculus	149-152
10485974-1	1999	Vitamin D binding protein (DBP) is a major carrier protein for the vitamin D metabolites, but may also play an important role in osteoclast differentiation.	Vitamin D	67-76	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
10612418-5	1999	Molecular cloning of 1alpha(OH)ase from several species has revealed that this enzyme belongs to a member of the cytochrome P450 enzyme superfamily, with highest homologies to the P450 hydroxylases for vitamin D derivatives.	Vitamin D	202-211	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	21-34
10496974-6	1999	Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct.	Vitamin D	115-124	bone gamma-carboxyglutamate protein	Homo sapiens	103-114
10519395-0	1999	Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.	Vitamin D	21-30	BCL2 apoptosis regulator	Homo sapiens	80-85
10519395-7	1999	Contrary to CrmA, overexpression of an antiapoptotic protein Bcl-2 in MCF-7 cells conferred a nearly complete protection from apoptosis induced by vitamin D compounds.	Vitamin D	147-156	BCL2 apoptosis regulator	Homo sapiens	61-66
10519395-8	1999	Taken together, these data indicate that vitamin D compounds induce apoptosis via a novel caspase- and p53-independent pathway that can be inhibited by Bcl-2.	Vitamin D	41-50	tumor protein p53	Homo sapiens	103-106
10519395-8	1999	Taken together, these data indicate that vitamin D compounds induce apoptosis via a novel caspase- and p53-independent pathway that can be inhibited by Bcl-2.	Vitamin D	41-50	BCL2 apoptosis regulator	Homo sapiens	152-157
10508929-1	1999	Regulation by vitamin D(3) of expression of the genes for stanniocalcins 1 and 2 (STC-1 and STC-2) was studied and their levels were shown to be oppositely regulated in the kidney and to remain unaffected in the ovary.	Vitamin D	14-23	stanniocalcin 1	Rattus norvegicus	58-80
10508929-1	1999	Regulation by vitamin D(3) of expression of the genes for stanniocalcins 1 and 2 (STC-1 and STC-2) was studied and their levels were shown to be oppositely regulated in the kidney and to remain unaffected in the ovary.	Vitamin D	14-23	stanniocalcin 1	Rattus norvegicus	82-87
10385427-0	1999	Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas.	Vitamin D	27-36	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	68-77
10510471-0	1999	Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2.	Vitamin D	16-25	tumor necrosis factor	Homo sapiens	37-45
10427145-5	1999	We report here that the vitamin D analogue EB1089 interferes with the IGF-IR signaling pathway by attenuating IGF-I-induced tyrosine phosphorylation of IRS-1, and to a lesser extent, IRS-2.	Vitamin D	24-33	insulin like growth factor 1	Homo sapiens	70-75
10438498-8	1999	Furthermore, with stably transfected cell lines, we demonstrate that the C/EBP binding site in the CD14 promoter plays a critical role for mediating TGF-beta signaling in the synergistic activation of CD14 expression by vitamin D(3) and TGF-beta during U937 differentiation.	Vitamin D	220-229	CCAAT enhancer binding protein alpha	Homo sapiens	73-78
10428857-4	1999	CaT1 shows homology (75% amino acid sequence identity) to the apical calcium channel ECaC recently cloned from vitamin D-responsive cells of rabbit kidney and is structurally related to the capsaicin receptor and the TRP family of ion channels.	Vitamin D	111-120	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	0-4
10417310-8	1999	We show in gel-shift assays that the sequence within a putative vitamin-D-response element in the human calbindin-D9k promoter can bind expressed IPF-1/PDX-1 protein, although we cannot confirm binding of the vitamin-D-receptor protein.	Vitamin D	64-73	S100 calcium binding protein G	Homo sapiens	104-117
10454569-3	1999	Here we show that the classical growth factor insulin-like growth factor I (IGF-I) potently promotes vitamin D(3)-induced macrophage differentiation of promyeloid cells, as assessed by measurement of a coordinate increase in expression of the integrin alpha subunit CD11b, the CD14 lipopolysaccharide receptor, and the macrophage-specific esterase, alpha-naphthyl acetate esterase, as early as 24 h following initiation of terminal differentiation.	Vitamin D	101-110	insulin like growth factor 1	Homo sapiens	76-81
10454569-4	1999	Addition of IGF-I to cells undergoing vitamin D(3)-induced differentiation also leads to an early increase in expression of cyclin E, phosphorylation of the retinoblastoma tumor suppressor protein, and a doubling of the cell number.	Vitamin D	38-47	insulin like growth factor 1	Homo sapiens	12-17
10385427-8	1999	These data are consistent with the emerging hypothesis that vitamin D through its active form does not directly turn off CYP1alpha mRNA production but, rather, strongly stimulates CYP24, thereby masking CYP1alpha activity.	Vitamin D	60-69	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	121-130
10385427-8	1999	These data are consistent with the emerging hypothesis that vitamin D through its active form does not directly turn off CYP1alpha mRNA production but, rather, strongly stimulates CYP24, thereby masking CYP1alpha activity.	Vitamin D	60-69	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	203-212
10321413-4	1999	Paricalcitol is a new vitamin D analogue that is safe and effective in suppressing elevated concentrations of PTH in patients with established hyperparathyroidism who are maintained on chronic hemodialysis.	Vitamin D	22-31	parathyroid hormone	Homo sapiens	110-113
10681663-0	1999	Transcriptional and post-transcriptional regulation of PTH gene expression by vitamin D, calcium and phosphate.	Vitamin D	78-87	parathyroid hormone	Homo sapiens	55-58
10336890-3	1999	However, the same sequence separated by three nucleotides (DR3) acts as a strong vitamin D response element.	Vitamin D	81-90	TNF receptor superfamily member 25	Homo sapiens	59-62
10321839-1	1999	The sequences in the rat osteocalcin gene that lie 3" to the vitamin D response element (VDRE) contain a GGTTTGG motif (-420 to -414) that is essential for transcriptional activation of osteocalcin-CAT (OC-CAT) fusion genes by 1,25(OH)2D3.	Vitamin D	61-70	bone gamma-carboxyglutamate protein	Rattus norvegicus	25-36
10321839-1	1999	The sequences in the rat osteocalcin gene that lie 3" to the vitamin D response element (VDRE) contain a GGTTTGG motif (-420 to -414) that is essential for transcriptional activation of osteocalcin-CAT (OC-CAT) fusion genes by 1,25(OH)2D3.	Vitamin D	61-70	bone gamma-carboxyglutamate protein	Rattus norvegicus	186-197
10218951-1	1999	Circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) are dependent on activity of the renal mitochondrial cytochrome P450 enzyme, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-hydroxylase).	Vitamin D	41-50	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	169-208
10320521-1	1999	Pseudovitamin D-defiency rickets (PDDR) is an autosomal recessive disorder characterized by hypocalcemia, rickets (which are resistant to treatment with vitamin D), and low or undetectable serum levels of 1,25-dihydroxyvitamin D (1,25(OH)2D).	Vitamin D	6-15	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	34-38
10436401-12	1999	In conclusion, our data indicate that substitution with vitamin D(3) metabolites and calcium can prevent deleterious bone effects of hypoparathyroidism in hemodialysis patients and in patients with normal kidney function and may compensate for the missing PTH action.	Vitamin D	56-65	parathyroid hormone	Homo sapiens	256-259
10022617-5	1999	Indeed, the absence of hypersensitivity was accompanied by inhibition of basal and vitamin D-dependent enhancement of OC gene transcription.	Vitamin D	83-92	bone gamma-carboxyglutamate protein	Rattus norvegicus	118-120
10406465-2	1999	In pituitary GH3 cells, vitamin D increases the levels of PRL transcripts and stimulates the PRL promoter.	Vitamin D	24-33	prolactin	Rattus norvegicus	58-61
10406465-2	1999	In pituitary GH3 cells, vitamin D increases the levels of PRL transcripts and stimulates the PRL promoter.	Vitamin D	24-33	prolactin	Rattus norvegicus	93-96
10406465-3	1999	We have analyzed the role of GHF-1 and of the vitamin D receptor (VDR) to confer vitamin D responsiveness to the PRL promoter.	Vitamin D	46-55	prolactin	Homo sapiens	113-116
10406465-8	1999	Truncation of the last 12 C-terminal amino acids of VDR, which contain the ligand-dependent activation function (AF2), abolishes regulation by vitamin D, suggesting that binding of coactivators to this region mediates ligand-dependent stimulation of the PRL promoter by the receptor.	Vitamin D	143-152	prolactin	Homo sapiens	254-257
10406465-9	1999	Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor.	Vitamin D	168-177	CREB binding protein	Homo sapiens	91-111
10406465-9	1999	Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor.	Vitamin D	168-177	CREB binding protein	Homo sapiens	113-116
10356581-11	1999	Normalization of serum calcium by calcium substitution and vitamin D administration will normalize PTH and improve mineralization of the skeleton.	Vitamin D	59-68	parathyroid hormone	Homo sapiens	99-102
10222046-1	1999	A putative transcription factor binds a site adjacent to the negative vitamin D responsive element (VDRE) in the promoter region of the human parathyroid hormone gene.	Vitamin D	70-79	parathyroid hormone	Homo sapiens	142-161
10323401-1	1999	Vitamin D regulates parathyroid cell proliferation and secretion of PTH.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	68-71
9930996-2	1999	These sites overlap elements that independently or in combination contribute to basal and vitamin D-stimulated OC gene transcription.	Vitamin D	90-99	bone gamma-carboxyglutamate protein	Homo sapiens	111-113
10067845-15	1999	This finding, that differentiating agents such as vitamin D and A derivatives are potent inducers of AR, may have clinical implications in the treatment of prostate cancer.	Vitamin D	50-59	androgen receptor	Homo sapiens	101-103
10077002-1	1999	1 ,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] negatively regulates expression of the avian PTH (aPTH) gene transcript, and a vitamin D response element (VDRE) near the promoter of the aPTH gene had previously been identified.	Vitamin D	15-24	parathyroid hormone	Homo sapiens	86-89
10069185-5	1999	Based on its homology to endopeptidases, it is postulated that PHEX/Phex is involved in the activation or inactivation of a peptide hormone(s) which plays a key role in the regulation of bone mineralization, renal Pi handling and vitamin D metabolism.	Vitamin D	230-239	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	63-67
10069185-5	1999	Based on its homology to endopeptidases, it is postulated that PHEX/Phex is involved in the activation or inactivation of a peptide hormone(s) which plays a key role in the regulation of bone mineralization, renal Pi handling and vitamin D metabolism.	Vitamin D	230-239	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	68-72
9930996-0	1999	Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo.	Vitamin D	37-46	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
9930996-5	1999	We report that chromatin hyperacetylation blocks vitamin D stimulation of OC transcription and prevents a key transition in the chromatin structure of the OC gene which is required for formation of the distal DNase I hypersensitive site.	Vitamin D	49-58	bone gamma-carboxyglutamate protein	Homo sapiens	74-76
9886808-0	1999	AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation.	Vitamin D	9-18	bone gamma-carboxyglutamate protein	Rattus norvegicus	73-84
10593571-2	1999	Since the vitamin D binding protein (DBP) is the main transporter for vitamin D and DBP has immunomodulatory properties itself, we investigated three polymorphic sites within the DBP gene as candidates for type 1 diabetes susceptibility for the first time.	Vitamin D	10-19	D site albumin promoter binding protein	Mus musculus	37-40
10593571-2	1999	Since the vitamin D binding protein (DBP) is the main transporter for vitamin D and DBP has immunomodulatory properties itself, we investigated three polymorphic sites within the DBP gene as candidates for type 1 diabetes susceptibility for the first time.	Vitamin D	10-19	D site albumin promoter binding protein	Mus musculus	84-87
10593571-2	1999	Since the vitamin D binding protein (DBP) is the main transporter for vitamin D and DBP has immunomodulatory properties itself, we investigated three polymorphic sites within the DBP gene as candidates for type 1 diabetes susceptibility for the first time.	Vitamin D	10-19	D site albumin promoter binding protein	Mus musculus	84-87
10408700-8	1999	Transactivation of the human osteocalcin vitamin D response element (VDRE) by LH was not enhanced in the presence of SR11238, although the expression of E-cadherin in these cells was additively up-regulated in the presence of both compounds.	Vitamin D	41-50	bone gamma-carboxyglutamate protein	Homo sapiens	29-40
9888267-10	1999	Furthermore, vitamin D compounds, although not able to induce apoptosis when used alone, potentiate apoptosis induced by 9-cis RA in HL-60 cells and differentially regulate the expression of the apoptosis-related gene products bcl-2 and bax.	Vitamin D	13-22	BCL2 apoptosis regulator	Homo sapiens	227-232
9888267-10	1999	Furthermore, vitamin D compounds, although not able to induce apoptosis when used alone, potentiate apoptosis induced by 9-cis RA in HL-60 cells and differentially regulate the expression of the apoptosis-related gene products bcl-2 and bax.	Vitamin D	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	237-240
9868284-17	1999	In addition, the activity of these enzymes in resting zone cells, but not growth zone cells, is regulated by TGFbeta1 by increasing gene transcription, indicating that cell maturation-dependent autocrine/paracrine pathways exist for regulating vitamin D metabolite production.	Vitamin D	244-253	transforming growth factor beta 1	Homo sapiens	109-117
9886808-3	1999	The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, stimulates transcription of the tissue-specific osteocalcin (OC) gene in osteoblastic cells.	Vitamin D	21-30	bone gamma-carboxyglutamate protein	Rattus norvegicus	106-117
9886808-3	1999	The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, stimulates transcription of the tissue-specific osteocalcin (OC) gene in osteoblastic cells.	Vitamin D	21-30	bone gamma-carboxyglutamate protein	Rattus norvegicus	119-121
9886808-4	1999	The rat OC vitamin D response element contains an internal acitvating protein-1 (AP-1) site.	Vitamin D	11-20	bone gamma-carboxyglutamate protein	Rattus norvegicus	8-10
9886808-5	1999	Here, we report for the first time that this AP-1 site is critical for the transcriptional enhancement of rat osteocalcin gene expression mediated by vitamin D.	Vitamin D	150-159	bone gamma-carboxyglutamate protein	Rattus norvegicus	110-121
9886808-8	1999	These results suggest a functional interaction between the hormone receptor and nuclear oncoproteins at the rat OC vitamin D response element.	Vitamin D	115-124	bone gamma-carboxyglutamate protein	Rattus norvegicus	112-114
10048459-3	1999	The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals, and increased markedly after administration of 1,25-dihydroxyvitamin D3.	Vitamin D	47-56	POU class 1 homeobox 1	Rattus norvegicus	14-19
9916136-1	1999	A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP"s biological functions in vitamin D metabolism and action.	Vitamin D	28-37	D site albumin promoter binding protein	Mus musculus	55-58
9916136-1	1999	A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP"s biological functions in vitamin D metabolism and action.	Vitamin D	28-37	D site albumin promoter binding protein	Mus musculus	135-138
9916136-2	1999	On vitamin D-replete diets, DBP-/- mice had low levels of total serum vitamin D metabolites but were otherwise normal.	Vitamin D	3-12	D site albumin promoter binding protein	Mus musculus	28-31
9916136-2	1999	On vitamin D-replete diets, DBP-/- mice had low levels of total serum vitamin D metabolites but were otherwise normal.	Vitamin D	70-79	D site albumin promoter binding protein	Mus musculus	28-31
9916136-3	1999	When maintained on vitamin D-deficient diets for a brief period, the DBP-/-, but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency.	Vitamin D	19-28	D site albumin promoter binding protein	Mus musculus	69-72
9916136-3	1999	When maintained on vitamin D-deficient diets for a brief period, the DBP-/-, but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency.	Vitamin D	188-197	D site albumin promoter binding protein	Mus musculus	69-72
9916136-4	1999	DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver.	Vitamin D	103-112	D site albumin promoter binding protein	Mus musculus	0-3
9916136-5	1999	After an overload of vitamin D, DBP-/- mice were unexpectedly less susceptible to hypercalcemia and its toxic effects.	Vitamin D	21-30	D site albumin promoter binding protein	Mus musculus	32-35
9916136-6	1999	Peak steady-state mRNA levels of the vitamin D-dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP-/- mice.	Vitamin D	37-46	D site albumin promoter binding protein	Mus musculus	123-126
9916136-7	1999	Thus, the role of DBP is to maintain stable serum stores of vitamin D metabolites and modulate the rates of its bioavailability, activation, and end-organ responsiveness.	Vitamin D	60-69	D site albumin promoter binding protein	Mus musculus	18-21
9915868-4	1999	Vitamin D intake is a second factor, as active calcium transport is directly and proportionally dependent on the presence in the intestinal cell of calbindin D9k, the biosynthesis of which is totally vitamin D dependent.	Vitamin D	0-9	S100 calcium binding protein G	Homo sapiens	148-161
9915868-4	1999	Vitamin D intake is a second factor, as active calcium transport is directly and proportionally dependent on the presence in the intestinal cell of calbindin D9k, the biosynthesis of which is totally vitamin D dependent.	Vitamin D	200-209	S100 calcium binding protein G	Homo sapiens	148-161
10334668-8	1999	The active vitamin D metabolites alfacalcidol and calcitriol may, under some circumstances, improve anaemia and reduce epoetin dosage requirements.	Vitamin D	11-20	erythropoietin	Homo sapiens	119-126
10048459-5	1999	Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function.	Vitamin D	56-65	POU class 1 homeobox 1	Rattus norvegicus	10-15
9825725-0	1998	Nongenomic signaling by vitamin D: a new face of Src.	Vitamin D	24-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
9827697-0	1998	Additional protein factors play a role in the formation of VDR/RXR complexes on vitamin D response elements.	Vitamin D	80-89	vitamin D receptor	Sus scrofa	59-62
9837822-1	1998	Vitamin D-dependent rickets type I (VDDR-I), also known as pseudo-vitamin D-deficiency rickets, appears to result from deficiency of renal vitamin D 1alpha-hydroxylase activity.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
9837822-1	1998	Vitamin D-dependent rickets type I (VDDR-I), also known as pseudo-vitamin D-deficiency rickets, appears to result from deficiency of renal vitamin D 1alpha-hydroxylase activity.	Vitamin D	66-75	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
9972311-1	1998	The apparent high degree of homology of a blood protein with a unique dual binding affinity for two distinct hormones, thyroxin (T4) and vitamin D, isolated from a turtle, Trachemys scripta (Family Emydidae) and mammalian vitamin D binding protein (DBP) prompted further interspecific comparison to better understand the structure of functional binding sites.	Vitamin D	137-146	D-box binding PAR bZIP transcription factor	Homo sapiens	249-252
9825725-2	1998	Recently, calcitriol (the hormonal form of vitamin D) has been shown to stimulate the enzymatic activity of a nonreceptor protein tyrosine kinase, Src, in keratinocytes and colonocytes.	Vitamin D	43-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	147-150
9825725-6	1998	The synthesis of vitamin D analogs capable of selective activation or inhibition of the Src-mediated signaling pathway(s) may be a new, promising approach to expanding the therapeutic scope and clinical utility of these compounds.	Vitamin D	17-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	88-91
9846632-17	1998	Densitometric analyses indicate that the vitamin D compounds lower the bcl-2/bax ratio favouring increased susceptibility of MCF-7 cells to undergo apoptosis.	Vitamin D	41-50	BCL2 apoptosis regulator	Homo sapiens	71-76
9799830-0	1998	Gastric fundectomy in the rat: effects on mineral and bone metabolism, with emphasis on the gastrin-calcitonin-parathyroid hormone-vitamin D axis.	Vitamin D	131-140	parathyroid hormone	Rattus norvegicus	111-130
9846632-17	1998	Densitometric analyses indicate that the vitamin D compounds lower the bcl-2/bax ratio favouring increased susceptibility of MCF-7 cells to undergo apoptosis.	Vitamin D	41-50	BCL2 associated X, apoptosis regulator	Homo sapiens	77-80
9801142-1	1998	1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65.	Vitamin D	19-28	nuclear factor kappa B subunit 1	Homo sapiens	167-176
9774468-1	1998	Vitamin D-binding protein (DBP)/Gc-globulin, the major carrier of vitamin D and its metabolites in blood, is synthesized predominantly in the liver in a developmentally regulated fashion.	Vitamin D	66-75	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
9801142-1	1998	1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65.	Vitamin D	19-28	iodothyronine deiodinase 3	Homo sapiens	42-44
9801142-1	1998	1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65.	Vitamin D	19-28	nuclear factor kappa B subunit 1	Homo sapiens	215-218
9801142-1	1998	1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65.	Vitamin D	19-28	nuclear factor kappa B subunit 1	Homo sapiens	95-104
9808142-1	1998	The active metabolite of vitamin D, calcitriol [1,25(OH)2D3] suppresses parathyroid hormone (PTH) gene transcription and PTH secretion.	Vitamin D	25-34	parathyroid hormone	Rattus norvegicus	72-91
9808143-0	1998	Suppression of parathyroid hormone secretion in hemodialysis patients by a novel vitamin D analogue: 19-nor-1,25-dihydroxyvitamin D2.	Vitamin D	81-90	parathyroid hormone	Homo sapiens	15-34
9808145-2	1998	The treatment of this disorder with vitamin D compounds, such as calcitriol, although effective at suppressing parathyroid hormone (PTH) secretion, may promote the development of hypercalcemia and hyperphosphatemia, thus increasing the risk for metastatic calcification.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	111-130
9808143-0	1998	Suppression of parathyroid hormone secretion in hemodialysis patients by a novel vitamin D analogue: 19-nor-1,25-dihydroxyvitamin D2.	Vitamin D	81-90	nuclear receptor subfamily 4 group A member 3	Homo sapiens	104-109
9869191-10	1998	In HL-60 leukemic cells treated with vitamin D analogs, WAF-1 can be induced by nano- or picomolar concentrations of vitamin D analogs and correlates with the induction of a differentiated phenotype.	Vitamin D	37-46	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-61
9792587-2	1998	The objective of this study was to determine the prevalence of bone hyperresorption and parathyroid hormone (PTH)-vitamin D axis abnormalities in these patients.	Vitamin D	114-123	parathyroid hormone	Homo sapiens	88-107
9869191-10	1998	In HL-60 leukemic cells treated with vitamin D analogs, WAF-1 can be induced by nano- or picomolar concentrations of vitamin D analogs and correlates with the induction of a differentiated phenotype.	Vitamin D	117-126	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-61
9738509-2	1998	We and others have demonstrated that vitamin D analogs with little calcemic activities suppress the transcription of the parathyroid hormone-related peptide (PTHrP) gene, a major humor responsible for cancer hypercalcemia, and thereby prevent the development of hypercalcemic syndrome.	Vitamin D	37-46	parathyroid hormone-like peptide	Mus musculus	121-156
9699504-3	1998	Stimulation of phospholipase A2 in GC caused an increase in PKC, whereas inhibition of phospholipase A2 activity in RC cultures increased both basal and 24,25-(OH)2D3-induced PKC activity, suggesting that phospholipase A2 may play a central role in mediating the effects of the vitamin D metabolites on PKC.	Vitamin D	278-287	phospholipase A2 group IB	Homo sapiens	87-103
9699504-10	1998	These results demonstrate that vitamin D metabolite-induced changes in phospholipase A2 activity are directly related to changes in PKC activity.	Vitamin D	31-40	phospholipase A2 group IB	Homo sapiens	71-87
9699504-10	1998	These results demonstrate that vitamin D metabolite-induced changes in phospholipase A2 activity are directly related to changes in PKC activity.	Vitamin D	31-40	proline rich transmembrane protein 2	Homo sapiens	132-135
9738509-2	1998	We and others have demonstrated that vitamin D analogs with little calcemic activities suppress the transcription of the parathyroid hormone-related peptide (PTHrP) gene, a major humor responsible for cancer hypercalcemia, and thereby prevent the development of hypercalcemic syndrome.	Vitamin D	37-46	parathyroid hormone-like peptide	Mus musculus	158-163
9731705-2	1998	However, although a vitamin D response element (VDRE) has been reported in the promoter of the rat CaBP9k gene (at -490/-472), the CaBP9k promoter is weakly transactivated by 1,25-(OH)2D3.	Vitamin D	20-29	S100 calcium binding protein G	Homo sapiens	99-105
9731705-3	1998	Previous studies indicated that when MCF-7 cells are transfected with the rat CaBP9k VDRE ligated to the thymidine kinase promoter and treated with both 1,25-(OH)2D3 and T3 there is an enhancement of the response observed with 1,25-(OH)2D3 alone, suggesting direct cross-talk between thyroid hormone and the vitamin D endocrine system and activation via the formation of vitamin D receptor (VDR)-thyroid hormone receptor (TR) heterodimers.	Vitamin D	308-317	S100 calcium binding protein G	Homo sapiens	78-84
9718191-1	1998	The objective of this study was to compare the effect of ultraviolet radiation (UV) and oral vitamin D3 on the vitamin D status and parathyroid hormone (PTH) concentration in elderly nursing home patients.	Vitamin D	93-102	parathyroid hormone	Homo sapiens	132-151
9705822-1	1998	25-Hydroxyvitamin D3 1 alpha-hydroxylase (1 alpha-hydroxylase) catalyzes hydroxylation, mainly in the kidney, of 25-hydroxyvitamin D3 [25(OH)D3] into 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonal form of vitamin D, acting as a key enzyme of vitamin D biosynthesis.	Vitamin D	123-132	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	0-40
9697664-15	1998	This second generation vitamin D analog may have a wider therapeutic window than current vitamin D preparations, and thus may allow reduction in PTH with less hypercalcemia.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	145-148
9603973-4	1998	In vitamin D-deficient rats, the amounts of type II Na+-dependent Pi transporter (NaPi-2) protein and mRNA were decreased in the juxtamedullary kidney cortex, but not in the superficial cortex, compared with control rats.	Vitamin D	3-12	solute carrier family 34 member 1	Rattus norvegicus	82-88
9690035-2	1998	An active form of vitamin D acting as a ligand specific vitamin D receptor (VDR), 1 alpha,25(OH)2D3, is biosynthesized from cholesterol, and during this biosynthesis a renal 25-hydroxylation at the final stage by 25-hydroxyvitamin D3 1 alpha-hydroxylase is critical.	Vitamin D	18-27	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	213-253
9614081-0	1998	Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene.	Vitamin D	78-87	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	123-144
9717845-0	1998	Calreticulin inhibits vitamin D"s action on the PTH gene in vitro and may prevent vitamin D"s effect in vivo in hypocalcemic rats.	Vitamin D	22-31	parathyroid hormone	Rattus norvegicus	48-51
9603973-5	1998	The administration of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) to vitamin D-deficient rats increased the initial rate of Pi uptake as well as the amounts of NaPi-2 mRNA and protein in the juxtamedullary cortex.	Vitamin D	36-45	solute carrier family 34 member 1	Rattus norvegicus	156-162
9744151-3	1998	For example, in osteomalacia from vitamin D deficiency, bone-specific alkaline phosphatase may be grossly elevated because of enhanced osteoblastic activity, whereas the vitamin D dependent osteocalcin may be decreased.	Vitamin D	34-43	bone gamma-carboxyglutamate protein	Homo sapiens	190-201
9799895-0	1998	Vitamin D replacement in Asians with diabetes may increase insulin resistance.	Vitamin D	0-9	insulin	Homo sapiens	59-66
9556566-1	1998	We found that the human parathyroid hormone-related peptide (hPTHrP) gene contained a DNA element (nVDREhPTHrP) homologous to a negative vitamin D response element in the human parathyroid hormone gene.	Vitamin D	137-146	parathyroid hormone	Homo sapiens	24-43
9591744-9	1998	It is suggested that increasing the circulating IGF-I concentration through aggressive nutritional therapy and/or GH/IGF-I therapy with supplementation with vitamin D and/or calcium might improve bone growth and mineralization and prevent the development of osteoporosis and consequent fractures in these patients.	Vitamin D	157-166	insulin like growth factor 1	Homo sapiens	48-53
9579536-2	1998	Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified.	Vitamin D	171-180	phospholipase C gamma 1	Homo sapiens	49-71
9579536-2	1998	Previous studies from our laboratory showed that phospholipase C-gamma1 (PLC-gamma1) was upregulated transcriptionally by 1,25(OH)2D3 in normal human keratinocytes, and a vitamin D responsive element (VDRE) in its promoter region has been identified.	Vitamin D	171-180	phospholipase C gamma 1	Homo sapiens	73-83
9548563-0	1998	Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: glucocorticoid regulation of basal and vitamin D stimulated gene expression.	Vitamin D	142-151	bone gamma-carboxyglutamate protein	Rattus norvegicus	56-67
9548563-1	1998	We have examined the contribution of transcriptional mechanisms to the pleiotropic effects of glucocorticoids on basal and vitamin D stimulated expression of the developmentally regulated bone-specific osteocalcin (OC) gene.	Vitamin D	123-132	bone gamma-carboxyglutamate protein	Rattus norvegicus	202-213
9548563-1	1998	We have examined the contribution of transcriptional mechanisms to the pleiotropic effects of glucocorticoids on basal and vitamin D stimulated expression of the developmentally regulated bone-specific osteocalcin (OC) gene.	Vitamin D	123-132	bone gamma-carboxyglutamate protein	Rattus norvegicus	215-217
9591744-9	1998	It is suggested that increasing the circulating IGF-I concentration through aggressive nutritional therapy and/or GH/IGF-I therapy with supplementation with vitamin D and/or calcium might improve bone growth and mineralization and prevent the development of osteoporosis and consequent fractures in these patients.	Vitamin D	157-166	growth hormone 1	Homo sapiens	114-116
9591744-9	1998	It is suggested that increasing the circulating IGF-I concentration through aggressive nutritional therapy and/or GH/IGF-I therapy with supplementation with vitamin D and/or calcium might improve bone growth and mineralization and prevent the development of osteoporosis and consequent fractures in these patients.	Vitamin D	157-166	insulin like growth factor 1	Homo sapiens	117-122
9501950-0	1998	Relationship between disease activity and serum levels of vitamin D metabolites and PTH in rheumatoid arthritis.	Vitamin D	58-67	parathyroid hormone	Homo sapiens	84-87
9587402-2	1998	The calbindins are a family of vitamin D-dependent calcium-binding proteins found in the intestine (calbindin D-9k) and kidney (calbindin D-28k) and are thought to play a role in calcium transport and homeostasis.	Vitamin D	31-40	calbindin 1	Rattus norvegicus	4-13
9531195-7	1998	Target genes for 1,25(OH)2D3 including those encoding for the bone matrix proteins osteopontin (OPN) and osteocalcin (OCN), possess vitamin D response elements (VDRE) upstream of the transcriptional start site.	Vitamin D	132-141	bone gamma-carboxyglutamate protein	Homo sapiens	105-116
9531195-7	1998	Target genes for 1,25(OH)2D3 including those encoding for the bone matrix proteins osteopontin (OPN) and osteocalcin (OCN), possess vitamin D response elements (VDRE) upstream of the transcriptional start site.	Vitamin D	132-141	bone gamma-carboxyglutamate protein	Homo sapiens	118-121
9528951-7	1998	The amount of PiT-1 mRNA in the parathyroid of vitamin D-deficient rats was reduced compared with that in normal animals and increased markedly after administration of 1,25-dihydroxyvitamin D3.	Vitamin D	47-56	POU class 1 homeobox 1	Rattus norvegicus	14-19
9528951-9	1998	Thus, rat PiT-1 may contribute to the effects of Pi and vitamin D on parathyroid function.	Vitamin D	56-65	POU class 1 homeobox 1	Rattus norvegicus	10-15
9587160-10	1998	The modulatory effects of oestrogen and vitamin D on constitutive and bone-matrix induced IL-1 beta production by PBMCs may be of importance for bone remodelling during postmenopausal bone loss and at a site of fracture.	Vitamin D	40-49	interleukin 1 beta	Homo sapiens	90-99
11490527-8	1998	Plasma PTH concentrations were negatively correlated to dialysis duration, and to plasma concentrations of aluminum, calcium and 25 OH vitamin D but not to those of phosphate and bicarbonate.	Vitamin D	135-144	parathyroid hormone	Homo sapiens	7-10
9525348-11	1998	In summary, the increase in serum PTH in the elderly can be explained more by changes in vitamin D status than by declining renal function.	Vitamin D	89-98	parathyroid hormone	Homo sapiens	34-37
9792954-14	1998	These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene.	Vitamin D	220-229	parathyroid hormone	Homo sapiens	52-55
9514085-0	1998	Involvement of Src in the vitamin D signaling in human keratinocytes.	Vitamin D	26-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-18
9459385-0	1998	Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites.	Vitamin D	20-29	parathyroid hormone	Homo sapiens	71-90
9459385-1	1998	In this study, the effect of dietary calcium and vitamin D on serum parathyroid hormone and vitamin D metabolites was measured in 376 free-living women aged 65-77 y.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	68-87
9459385-8	1998	Serum parathyroid hormone was inversely correlated with serum calcidiol (r = -0.33, P &lt; 0.001) and the regression predicted that mean serum parathyroid hormone would be reduced in the elderly to concentrations considered normal in the young when serum calcidiol is 122 nmol/L (49 ng/mL); this would require a much higher recommended dietary allowance for vitamin D than 5 microg/d (200 IU/d).	Vitamin D	358-367	parathyroid hormone	Homo sapiens	6-25
9459385-8	1998	Serum parathyroid hormone was inversely correlated with serum calcidiol (r = -0.33, P &lt; 0.001) and the regression predicted that mean serum parathyroid hormone would be reduced in the elderly to concentrations considered normal in the young when serum calcidiol is 122 nmol/L (49 ng/mL); this would require a much higher recommended dietary allowance for vitamin D than 5 microg/d (200 IU/d).	Vitamin D	358-367	parathyroid hormone	Homo sapiens	143-162
9513092-2	1998	Both vitamin D analogues inhibited IGF-1 stimulated growth of MCF-7 cells and enhanced the production of IGFBP-3 as determined by Western-ligand blotting.	Vitamin D	5-14	insulin like growth factor 1	Homo sapiens	35-40
9509459-19	1998	Moreover, patients with low 25 (OH) vitamin D levels (n = 63) had significantly higher PTH concentrations (between 40 and 80 pg/ml, P &lt; 0.01) throughout the study period compared to patients (n = 66) with a sufficient 25(OH)D supply irrespective of graft function.	Vitamin D	36-45	parathyroid hormone	Homo sapiens	87-90
9509459-25	1998	PTH is constantly elevated for up to 2 years after kidney transplantation and is most probably related (a) to impaired graft function and (b) to suboptimal 25 OH vitamin D supply.	Vitamin D	162-171	parathyroid hormone	Homo sapiens	0-3
9792954-14	1998	These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene.	Vitamin D	220-229	parathyroid hormone 1 receptor	Homo sapiens	52-70
9541257-0	1998	Characteristics of vitamin D3 receptor (VDR) binding to the vitamin D response element (VDRE) in rat bone sialoprotein gene promoter.	Vitamin D	19-28	integrin-binding sialoprotein	Rattus norvegicus	101-118
9541257-3	1998	In previous studies, we have identified a vitamin D response element (VDRE) that is integrated with a novel inverted TATA box in the rat BSP promoter which mediates the suppression of BSP transcription (1).	Vitamin D	42-51	integrin-binding sialoprotein	Rattus norvegicus	137-140
9541257-3	1998	In previous studies, we have identified a vitamin D response element (VDRE) that is integrated with a novel inverted TATA box in the rat BSP promoter which mediates the suppression of BSP transcription (1).	Vitamin D	42-51	integrin-binding sialoprotein	Rattus norvegicus	184-187
9769714-1	1998	Pseudovitamin D-deficiency rickets (PDDR) is the first identified inborn error of vitamin D metabolism.	Vitamin D	6-15	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
9503046-7	1998	CONCLUSION: The use of both forms of vitamin D supplementation appears to be useful for patients with hypovitaminosis D, elevated PTH levels and high telopeptide excretion.	Vitamin D	37-46	parathyroid hormone	Homo sapiens	130-133
9769714-0	1998	Molecular cloning of (25-OH D)-1 alpha-hydroxylase: an approach to the understanding of vitamin D pseudo-deficiency.	Vitamin D	88-97	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	22-50
9333115-1	1997	Pseudovitamin D-deficiency rickets (PDDR) is an autosomal recessive disorder that may be due to impaired activity of 25-hydroxyvitamin D-1alpha-hydroxylase, a renal cytochrome P450 enzyme (P450[1alpha]) of the vitamin D pathway.	Vitamin D	6-15	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	36-40
9431991-4	1997	A variety of vitamin D metabolites caused the same repressive effect on IL-8 promoter activation as calcitriol.	Vitamin D	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
9431991-5	1997	However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR).	Vitamin D	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
9459182-1	1997	COUP-TF II/ARP-1 is an "orphan" steroid receptor that inhibits basal transcription, and represses trans-activation by the vitamin D, thyroid hormone and retinoid receptors.	Vitamin D	122-131	nuclear receptor subfamily 2 group F member 2	Homo sapiens	0-10
9459182-1	1997	COUP-TF II/ARP-1 is an "orphan" steroid receptor that inhibits basal transcription, and represses trans-activation by the vitamin D, thyroid hormone and retinoid receptors.	Vitamin D	122-131	nuclear receptor subfamily 2 group F member 2	Homo sapiens	11-16
9333115-9	1997	The availability of a cloned sequence for 1alpha-OHase generates novel tools for the study of the molecular etiology of PDDR, and will allow the investigation of other disturbances of vitamin D metabolism.	Vitamin D	184-193	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	42-54
9333116-0	1997	Interleukin-1alpha and beta in growth plate cartilage are regulated by vitamin D metabolites in vivo.	Vitamin D	71-80	interleukin 1 alpha	Rattus norvegicus	0-18
9333116-10	1997	Levels of IL-1beta, but not IL-1alpha, were affected by the vitamin D status of the animal.	Vitamin D	60-69	interleukin 1 beta	Rattus norvegicus	10-18
9333117-0	1997	Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes.	Vitamin D	86-95	bone gamma-carboxyglutamate protein	Homo sapiens	126-137
9333117-2	1997	In this study, we used these models to demonstrate a species difference in the regulation of the mouse and human osteocalcin genes by vitamin D.	Vitamin D	134-143	bone gamma-carboxyglutamate protein	Homo sapiens	113-124
9328351-12	1997	Increased understanding of these murine-human differences in osteocalcin regulation may shed light on the function of osteocalcin and its regulation by vitamin D in bone physiology.	Vitamin D	152-161	bone gamma-carboxyglutamate protein	Homo sapiens	61-72
9337080-3	1997	As an additional index of leukaemic cell differentiation, induction of expression of the phenotypic cell surface antigen, CD14, and the beta2-integrins, CD11b and CD18 by the vitamin D and retinoid compounds were monitored using fluorescence activated cell sorting (FACS) analyses.	Vitamin D	175-184	integrin subunit beta 2	Homo sapiens	163-167
9295274-1	1997	Renal 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] catalyzes metabolic activation of 25-hydroxyvitamin D3 into 1alpha, 25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], an active form of vitamin D, and is inhibited by 1alpha,25(OH)2D3.	Vitamin D	16-25	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	47-60
9295274-4	1997	These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR.	Vitamin D	71-80	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	106-119
9379127-0	1997	Vitamin D derivatives inhibit the mitogenic effects of IGF-I on MCF-7 human breast cancer cells.	Vitamin D	0-9	insulin like growth factor 1	Homo sapiens	55-60
9379138-7	1997	Vitamin D responsive elements (VDREs) consisting of direct hexanucleotide repeats with a spacer of three nucleotides have been identified in the promoter regions of positively controlled genes expressed in bone, such as osteocalcin, osteopontin, beta 3-integrin and vitamin D 24-OHase.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	220-231
9379127-9	1997	Our findings demonstrate that vitamin D derivatives limit responsiveness of MCF-7 cells to the mitogenic effects of IGF-I, which may be mediated by reduction of IGF-I receptor expression.	Vitamin D	30-39	insulin like growth factor 1	Homo sapiens	116-121
9285381-2	1997	We hypothesized that magnesium deficiency alters vitamin D metabolism by decreasing parathyroid hormone (PTH) response, resulting in decreased serum osteocalcin and decreased bone accretion.	Vitamin D	49-58	parathyroid hormone	Homo sapiens	84-103
9430985-0	1997	[Serum bone Gla-protein increases following short-term oral administration of active vitamin D3 in the elderly with vitamin D deficiency].	Vitamin D	85-94	bone gamma-carboxyglutamate protein	Homo sapiens	7-23
9260973-7	1997	This discussion presents the hypothesis that reduced epidermal vitamin D3 photosynthesis associated with high skin melanin content and/or decreased UV light intensity at distances from the equator, alone or when coupled with decreased dietary calcium and vitamin D, may be associated with reduced vitamin D stores and increased parathyroid hormone secretion.	Vitamin D	63-72	parathyroid hormone	Homo sapiens	328-347
9165035-14	1997	Furthermore, PTH may have a vitamin D-dependent influence on intestinal magnesium absorption.	Vitamin D	28-37	parathyroid hormone	Rattus norvegicus	13-16
9263752-1	1997	Administration of active vitamin D (calcitriol) improves insulin sensitivity in uraemic patients.	Vitamin D	25-34	insulin	Homo sapiens	57-64
9283130-0	1997	Calcitonin therapy in vitamin D intoxication.	Vitamin D	22-31	calcitonin related polypeptide alpha	Homo sapiens	0-10
9229185-4	1997	The decrease in circulating parathyroid hormone in osteoporotic patients treated with vitamin D reflects the success of the vitamin D treatment.	Vitamin D	86-95	parathyroid hormone	Homo sapiens	28-47
9229185-4	1997	The decrease in circulating parathyroid hormone in osteoporotic patients treated with vitamin D reflects the success of the vitamin D treatment.	Vitamin D	124-133	parathyroid hormone	Homo sapiens	28-47
9204985-5	1997	Fluorescence activated cell scanning (FACS) analyses indicated that the vitamin D derivatives readily induced the expression of the monocyte-associated cell surface antigen, CD14, and also the beta2-integrins, CD11b and CD18 in both cell lines after 48 h and 96 h treatment.	Vitamin D	72-81	integrin subunit beta 2	Homo sapiens	220-224
9207192-1	1997	In addition to suppressing prostate cell growth, vitamin D also up-regulates the expression of androgen receptor (AR) and prostate-specific antigen (PSA).	Vitamin D	49-58	androgen receptor	Homo sapiens	95-112
9207192-1	1997	In addition to suppressing prostate cell growth, vitamin D also up-regulates the expression of androgen receptor (AR) and prostate-specific antigen (PSA).	Vitamin D	49-58	androgen receptor	Homo sapiens	114-116
9200691-1	1997	1alpha,25-Dihydroxyvitamin D3, the vitamin D hormone, manifests its diverse biological properties by specifically binding to the vitamin D sterol-binding pockets of vitamin D-binding protein (DBP) and vitamin D receptor.	Vitamin D	19-28	D-box binding PAR bZIP transcription factor	Homo sapiens	192-195
9200691-2	1997	In the past, several affinity, photoaffinity, and chemical modification studies have been carried out to probe the vitamin D sterol-binding pocket of DBP and to evaluate the relationship between the structure of this pocket and the functions of the protein.	Vitamin D	115-124	D-box binding PAR bZIP transcription factor	Homo sapiens	150-153
9200691-8	1997	Overall, these studies suggested that the vitamin D sterol-binding pocket in DBP is sterically quite restrictive.	Vitamin D	42-51	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
9165035-0	1997	Parathyroid hormone increases bone formation and improves mineral balance in vitamin D-deficient female rats.	Vitamin D	77-86	parathyroid hormone	Rattus norvegicus	0-19
9165035-1	1997	The present study was designed to investigate whether enhanced bone formation due to intermittent PTH administration is dependent on vitamin D metabolites.	Vitamin D	133-142	parathyroid hormone	Rattus norvegicus	98-101
9165035-15	1997	Finally, short term PTH treatment is anabolic in bone of vitamin D-deficient rats when adequate mineral amounts are provided in the diet.	Vitamin D	57-66	parathyroid hormone	Rattus norvegicus	20-23
9045685-8	1997	Therefore, the 5"-flanking region of the human phospholipase C-gamma1 gene confers promoter activity and contains a DR6-type vitamin D-responsive element that mediates, at least in part, the enhanced expression of this gene in human keratinocytes by 1, 25-(OH)2D3.	Vitamin D	125-134	phospholipase C gamma 1	Homo sapiens	47-69
9150190-10	1997	Immunoblotting experiments demonstrated that all three vitamin D-related compounds induced the accumulation of insulin-like growth factor-binding protein 5 in cell-conditioned media.	Vitamin D	55-64	insulin like growth factor binding protein 5	Homo sapiens	111-155
9150190-13	1997	CONCLUSIONS AND IMPLICATIONS: Our results indicate that vitamin D-related compounds stimulate production of insulin-like growth factor-binding protein 5, thereby indirectly suppressing cell proliferation.	Vitamin D	56-65	insulin like growth factor binding protein 5	Homo sapiens	108-152
9075635-10	1997	Thus, a concerted action of the endothelial cell polypeptide ET-1 and 1,25(OH)2D3 may mediate an osteoanabolic effect of the vascular and endocrine vitamin D system.	Vitamin D	148-157	endothelin 1	Homo sapiens	61-65
9365187-5	1997	Aromatase mRNA was increasingly expressed in myeloid THP 1 cells differentiated along the monocyte/phagocyte pathway exploiting vitamin D and either granulocyte-macrophage-stimulating factor (GMCSF) or macrophage-stimulating factor (MCSF).	Vitamin D	128-137	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
9050887-1	1997	Calbindin-D28k, a calcium binding protein that is thought to act as a facilitator of calcium diffusion in intestine and kidney, is known to be regulated by vitamin D in these tissues.	Vitamin D	156-165	calbindin 1	Rattus norvegicus	0-9
9143355-1	1997	The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes.	Vitamin D	89-98	retinoid X receptor beta	Rattus norvegicus	138-146
9143355-1	1997	The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes.	Vitamin D	89-98	parathyroid hormone	Homo sapiens	299-318
9143355-1	1997	The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes.	Vitamin D	89-98	parathyroid hormone	Homo sapiens	320-323
9366495-0	1997	Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	87-126
9365187-6	1997	In long-term cultures, when sequentially exposed to vitamin D (days 0-21) and GMCSF (days 5-10) and plated on collagen, the amount of expression of aromatase mRNA steadily increased along with the increasing expression of osteopontin mRNA, alpha(v) integrin mRNA, c-fms (MCSF-receptor) mRNA and multinucleated cells developing.	Vitamin D	52-61	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	148-157
9045685-0	1997	Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element.	Vitamin D	86-95	phospholipase C gamma 1	Homo sapiens	21-43
9191975-0	1997	In vitro binding of vitamin D receptor occupied by 24R,25-dihydroxyvitamin D3 to vitamin D responsive element of human osteocalcin gene.	Vitamin D	20-29	bone gamma-carboxyglutamate protein	Homo sapiens	119-130
9062528-9	1997	In contrast, neonates with subclinical vitamin D deficiency had normalized serum PTH within 1 mo only when they were given 1000 IU ergocalciferol (25 micrograms)/d in addition to their formula.	Vitamin D	39-48	parathyroid hormone	Homo sapiens	81-84
9088064-4	1997	Based on histopathological and pathophysiological investigations, nodular hyperplasia is monoclonal neoplasia with abnormal parathyroid hormone (PTH) response to extracellular calcium and vitamin D.	Vitamin D	188-197	parathyroid hormone	Homo sapiens	124-143
9045869-0	1997	Vitamin D and gonadal steroid-resistant New World primate cells express an intracellular protein which competes with the estrogen receptor for binding to the estrogen response element.	Vitamin D	0-9	estrogen receptor 1	Homo sapiens	121-138
9045869-7	1997	We conclude that vitamin D-resistant and gonadal steroid-resistant NWP cells contain a protein(s) that may "silence" ER action by interacting directly with the ERE and interfering with ER binding.	Vitamin D	17-26	estrogen receptor 1	Homo sapiens	117-119
9045869-7	1997	We conclude that vitamin D-resistant and gonadal steroid-resistant NWP cells contain a protein(s) that may "silence" ER action by interacting directly with the ERE and interfering with ER binding.	Vitamin D	17-26	estrogen receptor 1	Homo sapiens	160-162
9191975-1	1997	We previously reported that 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] activates the human osteocalcin gene (hOC) through vitamin D receptor (VDR) and vitamin D responsive element (VDRE) in the same manner as 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2 D3] [17].	Vitamin D	44-53	bone gamma-carboxyglutamate protein	Homo sapiens	91-102
8995235-2	1997	In particular, in rat and human osteoblasts, 1,25-(OH)2D3 increases the expression of Osteocalcin by interacting, through a hormone-receptor complex, with a vitamin D-responsive element present in the promoter of the genes.	Vitamin D	157-166	bone gamma-carboxyglutamate protein	Homo sapiens	86-97
8990171-0	1997	YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene.	Vitamin D	14-23	YY1 transcription factor	Homo sapiens	0-3
8990171-0	1997	YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene.	Vitamin D	14-23	bone gamma-carboxyglutamate protein	Homo sapiens	106-117
8990171-4	1997	Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene.	Vitamin D	83-92	YY1 transcription factor	Homo sapiens	55-58
8990171-4	1997	Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene.	Vitamin D	83-92	bone gamma-carboxyglutamate protein	Homo sapiens	158-169
9013768-0	1997	DNA sequences downstream from the vitamin D response element of the rat osteocalcin gene are required for ligand-dependent transactivation.	Vitamin D	34-43	bone gamma-carboxyglutamate protein	Rattus norvegicus	72-83
9013768-1	1997	The sequences in the rat osteocalcin gene that lie 3" to the vitamin D response element (VDRE) have been shown to augment transcriptional activation by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	Vitamin D	61-70	bone gamma-carboxyglutamate protein	Rattus norvegicus	25-36
8990171-9	1997	Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.	Vitamin D	39-48	general transcription factor IIB	Homo sapiens	174-179
8990171-5	1997	We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.	Vitamin D	49-58	YY1 transcription factor	Homo sapiens	12-15
8990171-5	1997	We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.	Vitamin D	49-58	bone gamma-carboxyglutamate protein	Homo sapiens	90-101
8990171-5	1997	We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.	Vitamin D	49-58	YY1 transcription factor	Homo sapiens	129-132
8990171-5	1997	We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.	Vitamin D	157-166	YY1 transcription factor	Homo sapiens	12-15
8990171-5	1997	We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.	Vitamin D	157-166	bone gamma-carboxyglutamate protein	Homo sapiens	90-101
8990171-5	1997	We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.	Vitamin D	157-166	YY1 transcription factor	Homo sapiens	129-132
8990171-9	1997	Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.	Vitamin D	39-48	YY1 transcription factor	Homo sapiens	25-28
8990171-9	1997	Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.	Vitamin D	39-48	bone gamma-carboxyglutamate protein	Homo sapiens	64-75
27405232-6	1997	Western analysis of bcl-2 and bax protein levels revealed that combinations of the vitamin D and retinoid compounds decreased bcl-2 in HL-60 but not U937 cells, suggesting a change in the bcl-2/bax heterodimeric ratio in the former which would favour apoptosis.	Vitamin D	83-92	BCL2 apoptosis regulator	Homo sapiens	20-25
8988915-1	1997	Wintertime declines in vitamin D lead to increased concentrations of parathyroid hormone (PTH) and accelerated bone loss in postmenopausal women.	Vitamin D	23-32	parathyroid hormone	Homo sapiens	69-88
9037126-1	1997	The influence of growth hormone (GH) on calcium-phosphorus metabolism and modulation of vitamin D metabolism has been demonstrated, but the mechanism remains unclear.	Vitamin D	88-97	growth hormone 1	Homo sapiens	17-31
9037126-1	1997	The influence of growth hormone (GH) on calcium-phosphorus metabolism and modulation of vitamin D metabolism has been demonstrated, but the mechanism remains unclear.	Vitamin D	88-97	growth hormone 1	Homo sapiens	33-35
9037126-2	1997	We investigated the effect of a 6-month course of GH therapy on vitamin D and mineral metabolism in twelve GH-deficient children.	Vitamin D	64-73	growth hormone 1	Homo sapiens	50-52
9037126-11	1997	The results of this study confirmed the actions of GH on renal tubules with increases in calcium excretion and phosphorus reabsorption, and indicate that the action of GH on modulating vitamin D metabolism may be IGF-I mediated, not PTH mediated.	Vitamin D	185-194	growth hormone 1	Homo sapiens	168-170
9037126-11	1997	The results of this study confirmed the actions of GH on renal tubules with increases in calcium excretion and phosphorus reabsorption, and indicate that the action of GH on modulating vitamin D metabolism may be IGF-I mediated, not PTH mediated.	Vitamin D	185-194	insulin like growth factor 1	Homo sapiens	213-218
9328147-0	1997	Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines.	Vitamin D	0-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	32-35
9328147-5	1997	In conclusion, vitamin D analogues up-regulate p21 and p27 as an early event, which in turn could block the G1/S transition and induce growth inhibition in responsive cells.	Vitamin D	15-24	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-50
9030491-3	1997	Vitamin D supplementation in this age group improves calcium absorption, suppresses PTH, and decreases bone loss.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	84-87
27405232-6	1997	Western analysis of bcl-2 and bax protein levels revealed that combinations of the vitamin D and retinoid compounds decreased bcl-2 in HL-60 but not U937 cells, suggesting a change in the bcl-2/bax heterodimeric ratio in the former which would favour apoptosis.	Vitamin D	83-92	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33
27405232-6	1997	Western analysis of bcl-2 and bax protein levels revealed that combinations of the vitamin D and retinoid compounds decreased bcl-2 in HL-60 but not U937 cells, suggesting a change in the bcl-2/bax heterodimeric ratio in the former which would favour apoptosis.	Vitamin D	83-92	BCL2 apoptosis regulator	Homo sapiens	126-131
27405232-6	1997	Western analysis of bcl-2 and bax protein levels revealed that combinations of the vitamin D and retinoid compounds decreased bcl-2 in HL-60 but not U937 cells, suggesting a change in the bcl-2/bax heterodimeric ratio in the former which would favour apoptosis.	Vitamin D	83-92	BCL2 apoptosis regulator	Homo sapiens	126-131
27405232-6	1997	Western analysis of bcl-2 and bax protein levels revealed that combinations of the vitamin D and retinoid compounds decreased bcl-2 in HL-60 but not U937 cells, suggesting a change in the bcl-2/bax heterodimeric ratio in the former which would favour apoptosis.	Vitamin D	83-92	BCL2 associated X, apoptosis regulator	Homo sapiens	194-197
9425501-6	1997	When the 25(OH)D concentration became equal to or lower than 11.3 nmol/l (4.6 ng/ml), the PTH values reached the upper limit of normal values (55 pg/ml) found in vitamin D replete subjects.	Vitamin D	162-171	parathyroid hormone	Homo sapiens	90-93
8995749-2	1997	The safety and efficacy of the vitamin D analog, 1 alpha (OH)-vitamin D2, (1 alpha D2), which has less toxicity in animals than 1 alpha (OH)-vitamin D3, was tested in a multicenter study of 24 hemodialysis patients with secondary hyperparathyroidism [serum intact (i) PTH &gt; 400 pg/ml].	Vitamin D	31-40	parathyroid hormone	Homo sapiens	268-271
8923469-0	1996	Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.	Vitamin D	26-35	retinoid X receptor alpha	Rattus norvegicus	45-70
8968028-0	1996	Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells.	Vitamin D	13-22	bone gamma-carboxyglutamate protein	Homo sapiens	66-77
9010346-10	1996	In addition, the genomic action of each vitamin D compound was assessed in a rat osteosarcoma cell line (ROS 17/2.8) by measuring its ability to transactivate a gene construct containing the vitamin D response element of the osteocalcin gene linked to the growth hormone reporter gene.	Vitamin D	40-49	bone gamma-carboxyglutamate protein	Rattus norvegicus	225-236
9010346-10	1996	In addition, the genomic action of each vitamin D compound was assessed in a rat osteosarcoma cell line (ROS 17/2.8) by measuring its ability to transactivate a gene construct containing the vitamin D response element of the osteocalcin gene linked to the growth hormone reporter gene.	Vitamin D	191-200	bone gamma-carboxyglutamate protein	Rattus norvegicus	225-236
9435366-1	1997	Several studies have shown that vitamin D (Vit.	Vitamin D	32-41	vitrin	Homo sapiens	43-46
8933375-0	1996	Differential expression of M-CSF, LIF, and TNF-alpha genes in normal and malignant rat glial cells: regulation by lipopolysaccharide and vitamin D.	Vitamin D	137-146	tumor necrosis factor	Rattus norvegicus	43-52
8923469-0	1996	Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.	Vitamin D	26-35	bone gamma-carboxyglutamate protein	Rattus norvegicus	170-181
8822940-9	1996	The induction of WAF1 occurred at concentrations of vitamin D analogs as low as 10(-10) mol/L.	Vitamin D	52-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-21
8900396-1	1996	The binding of the 1,25-dihydroxyvitamin D3 receptor to the vitamin D response elements (VDREs) in the rat osteocalcin (OSC-DRE), mouse osteopontin (MOP-DRE), rat calbindin D-9k (CaBP-DRE), and human parathyroid hormone genes (PTH-DRE) was studied.	Vitamin D	33-42	bone gamma-carboxyglutamate protein	Rattus norvegicus	107-118
8816911-1	1996	One of the MMPs, stromelysin-1 (MMP-3) has been localized to extracellular matrix vesicles in growth plate chondrocyte cultures, suggesting involvement of this enzyme in remodeling of the extracellular matrix during endochondral development, a process which is regulated by the vitamin D metabolites, 1,25-(OH)2D3 and 24,25-(OH)2D3.	Vitamin D	278-287	matrix metallopeptidase 3	Homo sapiens	11-15
8822940-0	1996	A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia.	Vitamin D	16-25	cyclin dependent kinase inhibitor 1A	Homo sapiens	108-112
8918622-2	1996	We tested three new vitamin D analogues (CB 1093, EB 1213, GS 1725) in an attempt to identify potentially non hypercalcaemic compounds, capable of decreasing plasma parathyroid hormone (PTH) concentration.	Vitamin D	20-29	parathyroid hormone	Rattus norvegicus	165-184
9159226-0	1996	New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulin.	Vitamin D	55-64	calreticulin	Homo sapiens	193-205
9159226-4	1996	These will be reviewed with particular emphasis on the complex VDRE from the c-fos proto-oncogene promoter region and the inhibition of the vitamin D signal transduction pathway by the multifunctional protein, calreticulin.	Vitamin D	140-149	calreticulin	Homo sapiens	210-222
8765644-17	1996	Children with &lt;50 % of normal creatinine clearance should have PTH measured and activated vitamin D therapy should be started if PTH is elevated more than two to three times normal.	Vitamin D	93-102	parathyroid hormone	Homo sapiens	132-135
8768839-9	1996	These results suggest a selective modulation by vitamin D of the renal response to PTH; 1,25-(OH)2D3 facilitates PTH-induced calcium and sodium reabsorption, but does not influence PTH-induced cAMP excretion; phosphorus, potassium, and bicarbonate tubular transport, or 1 alpha-hydroxylation of 25-hydroxyvitamin D3.	Vitamin D	48-57	parathyroid hormone	Homo sapiens	83-86
8768839-9	1996	These results suggest a selective modulation by vitamin D of the renal response to PTH; 1,25-(OH)2D3 facilitates PTH-induced calcium and sodium reabsorption, but does not influence PTH-induced cAMP excretion; phosphorus, potassium, and bicarbonate tubular transport, or 1 alpha-hydroxylation of 25-hydroxyvitamin D3.	Vitamin D	48-57	parathyroid hormone	Homo sapiens	113-116
8903423-7	1996	The effects of the vitamin D compounds on the expression of two oncoproteins which may regulate apoptosis, bcl-2 and p53 were examined by Western analysis.	Vitamin D	19-28	BCL2 apoptosis regulator	Homo sapiens	107-112
8709103-1	1996	Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP).	Vitamin D	55-64	D-box binding PAR bZIP transcription factor	Homo sapiens	193-196
8842637-2	1996	The aim of this study was to evaluate the relation between maternal serum calcium and parathyroid hormone with reduced fetal growth in vitamin D deficient pregnant women.	Vitamin D	135-144	parathyroid hormone	Homo sapiens	86-105
8903423-7	1996	The effects of the vitamin D compounds on the expression of two oncoproteins which may regulate apoptosis, bcl-2 and p53 were examined by Western analysis.	Vitamin D	19-28	tumor protein p53	Homo sapiens	117-120
8903423-9	1996	In addition, the p21 protein, whose gene WAF-1 is induced by wild type p53, was also increased by both vitamin D compounds.	Vitamin D	103-112	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-20
8903423-9	1996	In addition, the p21 protein, whose gene WAF-1 is induced by wild type p53, was also increased by both vitamin D compounds.	Vitamin D	103-112	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-46
8903423-9	1996	In addition, the p21 protein, whose gene WAF-1 is induced by wild type p53, was also increased by both vitamin D compounds.	Vitamin D	103-112	tumor protein p53	Homo sapiens	71-74
8660573-1	1996	Serum vitamin D binding protein (DBP, also known as Gc-globulin) is a multifunctional protein capable of binding both vitamin D metabolites and actin.	Vitamin D	6-15	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
8603577-0	1996	Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain.	Vitamin D	10-19	bone gamma-carboxyglutamate protein	Rattus norvegicus	51-62
8761938-8	1996	In addition, the full-length VDR fusion protein was shown by gel shift analysis to bind weakly to the human osteocalcin gene vitamin D response element, an interaction greatly facilitated by addition of RXR alpha.	Vitamin D	125-134	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
8651937-9	1996	In gel shift assays, the binding of vitamin D receptor to the composite AP-1 plus vitamin-D responsive promoter region of the human osteocalcin gene after EB 1089 treatment was stronger and longer-lasting than after calcitriol treatment.	Vitamin D	82-91	bone gamma-carboxyglutamate protein	Homo sapiens	132-143
8655592-1	1996	Prior studies have shown that vitamin D regulation of protein kinase C activity (PKC) in the cell layer of chondrocyte cultures is cell maturation-dependent.	Vitamin D	30-39	protein kinase C alpha	Homo sapiens	81-84
8655592-10	1996	Moreover, the vitamin D-sensitive PKC in matrix vesicles was not dependent on calcium, whereas the vitamin D-sensitive enzyme in plasma membranes was calcium-dependent.	Vitamin D	14-23	protein kinase C alpha	Homo sapiens	34-37
8792407-1	1996	The main factors which regulate parathyroid hormone (PTH) production are calcium, phosphate, vitamin D, and estrogens.	Vitamin D	93-102	parathyroid hormone	Rattus norvegicus	32-51
8792407-1	1996	The main factors which regulate parathyroid hormone (PTH) production are calcium, phosphate, vitamin D, and estrogens.	Vitamin D	93-102	parathyroid hormone	Rattus norvegicus	53-56
8665957-7	1996	This effect was apparently mediated by stronger and longer lasting binding of the vitamin D receptor to the osteocalcin vitamin D responsive element by the 20-epi analogs.	Vitamin D	82-91	bone gamma-carboxyglutamate protein	Homo sapiens	108-119
8612541-5	1996	The inhibitory TGF beta response for each requires vitamin D response element (VDRE) sequences, although there are additional contributions from proximal basal regulatory elements.	Vitamin D	51-60	transforming growth factor, beta 1	Rattus norvegicus	15-23
8603577-1	1996	Osteocalcin (OC) is a bone-specific vitamin D- responsive protein that is developmentally expressed during osteoblast differentiation.	Vitamin D	36-45	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-11
8603577-1	1996	Osteocalcin (OC) is a bone-specific vitamin D- responsive protein that is developmentally expressed during osteoblast differentiation.	Vitamin D	36-45	bone gamma-carboxyglutamate protein	Rattus norvegicus	13-15
8603577-11	1996	Cells carrying the 1.1-kb promoter show DNase I hypersensitivity at both the basal promoter and the vitamin D response element-containing domains, locations that also exhibit DNase I hypersensitivity in the endogenous OC promoter.	Vitamin D	100-109	bone gamma-carboxyglutamate protein	Rattus norvegicus	218-220
8833143-1	1996	The hypophosphatemic (Hyp) mouse is the murine homolog of hypophosphatemic vitamin-D-resistant rickets (HYP) in human.	Vitamin D	75-84	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	22-25
8833143-1	1996	The hypophosphatemic (Hyp) mouse is the murine homolog of hypophosphatemic vitamin-D-resistant rickets (HYP) in human.	Vitamin D	75-84	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	104-107
8772587-14	1996	The maintenance of PTH within the normal range for healthy adults by vitamin D and calcium treatment might constitute an approach for the prevention of bone loss in the entire aged population.	Vitamin D	69-78	parathyroid hormone	Homo sapiens	19-22
9084672-14	1996	Further, MMP and plasminogen activator activities in MVs and PMs are regulated by vitamin D metabolites.	Vitamin D	82-91	matrix metallopeptidase 3	Homo sapiens	9-12
8840332-2	1996	There is a search for other vitamin D sterols that suppress PTH but cause less hypercalcaemia.	Vitamin D	28-37	parathyroid hormone	Homo sapiens	60-63
9084640-6	1996	The TATA box is overlapped by a vitamin D3 response element (VDRE) which appears to mediate vitamin D suppression of BSP gene transcription by competing with the TATA-binding protein (TBP) for occupancy of the site of the pre-initiation complex formation.	Vitamin D	32-41	integrin binding sialoprotein	Homo sapiens	117-120
8911879-4	1996	After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change.	Vitamin D	110-119	bone gamma-carboxyglutamate protein	Homo sapiens	54-65
8911879-4	1996	After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change.	Vitamin D	110-119	parathyroid hormone	Homo sapiens	70-73
8840303-1	1996	The main factors which regulate parathyroid hormone (PTH) production are calcium, phosphate, vitamin D and the sex steroids, estrogens and progestagins.	Vitamin D	93-102	parathyroid hormone	Rattus norvegicus	32-51
8840303-1	1996	The main factors which regulate parathyroid hormone (PTH) production are calcium, phosphate, vitamin D and the sex steroids, estrogens and progestagins.	Vitamin D	93-102	parathyroid hormone	Rattus norvegicus	53-56
8723391-4	1996	Human thyroid hormone, retinoic acid, vitamin D, and several orphan receptors prefer to work as heterodimers with retinoic X receptor (RXR).	Vitamin D	38-47	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	123-133
8632677-4	1996	The TNF inhibitors pentoxifylline(PTF) and dichloroisocoumarin (DCI) inhibited TNF synthesis by U937 cells and abrogated the increase in resistance to TNF seen with VitD(3).	Vitamin D	165-169	tumor necrosis factor	Homo sapiens	4-7
8835303-0	1995	Vitamin D-dependent seasonal variation of PTH in growing male adolescents.	Vitamin D	0-9	parathyroid hormone	Homo sapiens	42-45
8883116-1	1996	Although vitamin D supplementation in the frail elderly improves calcium absorption, suppresses parathyroid hormone, decreases bone loss and reduces the risk of fractures, such treatment may be ineffective in patients with vertebral osteoporosis, because of impaired vitamin D metabolism or resistance to the action of vitamin D metabolites on the bowel.	Vitamin D	9-18	parathyroid hormone	Homo sapiens	96-115
8835303-13	1995	Modulation of PTH secretion by vitamin D appears to be a physiological mechanism occurring during adolescence.	Vitamin D	31-40	parathyroid hormone	Homo sapiens	14-17
7588324-5	1995	Vitamin D-induced transcription was assayed in transfected ROS 17/2.8 osteosarcoma cells using chloraminphenicol acetyltransferase constructs containing the vitamin D-responsive element (VDRE) at its native locus in the rat OC promoter as well as fused to a heterologous promoter.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	224-226
7588324-6	1995	Both ST and OA inhibit VDRE-mediated and vitamin D-dependent enhancement of OC gene transcription as well as OC biosynthesis, as assessed by RIAs.	Vitamin D	41-50	bone gamma-carboxyglutamate protein	Rattus norvegicus	76-78
8522595-2	1995	A number of known modulators of bone cell function, including vitamin D, act through this receptor family, suggesting that calreticulin may regulate their action in bone cells.	Vitamin D	62-71	calreticulin	Mus musculus	123-135
8522595-4	1995	Purified calreticulin inhibited the binding of the vitamin D receptor to characterized vitamin D response elements in gel retardation assays.	Vitamin D	51-60	calreticulin	Mus musculus	9-21
8522595-8	1995	Constitutive calreticulin expression inhibited basal and vitamin D-induced expression of the osteocalcin gene, whereas osteopontin gene expression was unaffected.	Vitamin D	57-66	calreticulin	Mus musculus	13-25
8547182-7	1995	Aromatase is expressed and regulated in the human THP 1 myeloid leukemia cell line after vitamin D/GMCSF-propagated differentiation.	Vitamin D	89-98	GLI family zinc finger 2	Homo sapiens	50-55
8547182-10	1995	Vitamin D-differentiated THP 1 cells produce a net excess of estradiol in culture supernatants, if testosterone is given as aromatase substrate.	Vitamin D	0-9	GLI family zinc finger 2	Homo sapiens	25-30
8748356-10	1995	CONCLUSIONS: In selected patients with depressed PTH levels, long-term withdrawal of vitamin D during HPN increases LSBMC and levels of PTH and 1,25(OH)2D.	Vitamin D	85-94	parathyroid hormone	Homo sapiens	49-52
7485144-1	1995	The active metabolite of vitamin D, calcitriol (1 alpha,25-(OH)2D3), suppresses parathyroid hormone (PTH) gene transcription.	Vitamin D	25-34	parathyroid hormone	Rattus norvegicus	80-99
7485144-1	1995	The active metabolite of vitamin D, calcitriol (1 alpha,25-(OH)2D3), suppresses parathyroid hormone (PTH) gene transcription.	Vitamin D	25-34	parathyroid hormone	Rattus norvegicus	101-104
8748356-10	1995	CONCLUSIONS: In selected patients with depressed PTH levels, long-term withdrawal of vitamin D during HPN increases LSBMC and levels of PTH and 1,25(OH)2D.	Vitamin D	85-94	parathyroid hormone	Homo sapiens	136-139
7649081-0	1995	Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.	Vitamin D	174-183	parathyroid hormone	Rattus norvegicus	0-19
8560596-12	1995	Since all of these patients have received vitamin D therapy for long periods, we suggest that vitamin D may have prevented the deleterious effect of PTH on myocardial function.	Vitamin D	94-103	parathyroid hormone	Homo sapiens	149-152
8580878-6	1995	Calcium (3 mM) plus K+ (50 mM) greatly increased CT secretion in both the control and vitamin D-treated groups.	Vitamin D	86-95	calcitonin related polypeptide alpha	Homo sapiens	49-51
8785878-21	1995	If a genetic defect decreases the affinity of a suppressive receptor/ligand complex for the regulatory element of IL-6 or TGF-alpha, for example, then these cells could be relatively resistant to homeostatic regulation by indigenous corticosteroids, vitamin D, and retinoids.	Vitamin D	250-259	interleukin 6	Homo sapiens	114-118
7475095-1	1995	Alpha-fetoprotein (AFP) is an oncofetal protein, classified in an "albuminoid" superfamily (with albumin and Vitamin-D binding (Gc) protein) comprising molecules with three characteristic globular domains.	Vitamin D	109-118	alpha fetoprotein	Homo sapiens	0-17
7475095-1	1995	Alpha-fetoprotein (AFP) is an oncofetal protein, classified in an "albuminoid" superfamily (with albumin and Vitamin-D binding (Gc) protein) comprising molecules with three characteristic globular domains.	Vitamin D	109-118	alpha fetoprotein	Homo sapiens	19-22
7649081-1	1995	The aim of the present work was to characterize at the molecular level the mechanism of PTH resistance in a rat model of secondary hyperparathyroidism resulting from vitamin D deprivation.	Vitamin D	166-175	parathyroid hormone	Rattus norvegicus	88-91
7649081-11	1995	Normalization of PTH/PTHrp receptor mRNA expression was observed after vitamin D supplementation (D-D+ rats), but not after correction of the hypocalcemia and secondary hyperparathyroidism by oral lactose and calcium supplementation.	Vitamin D	71-80	parathyroid hormone	Rattus norvegicus	17-20
7649081-12	1995	In the epi/metaphysis, an approximately 2-fold increase in PTH/PTHrp receptor mRNA was also observed in the D-D- rats compared to the controls; this increase was partially corrected upon normalization of the calcemia and PTH levels with either vitamin D (D-D+ group) or lactose/calcium (D-Ca+ group).	Vitamin D	244-253	parathyroid hormone	Rattus norvegicus	59-62
7622489-0	1995	Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism.	Vitamin D	127-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	73-88
7640305-1	1995	The effects of two vitamin D analogs, 1,25-dihydroxyvitamin D-2 and 24-epi-1,25-dihydroxyvitamin D-2, were examined on osteocalcin gene expression in the rat osteosarcoma cell line ROS 17/28.	Vitamin D	19-28	bone gamma-carboxyglutamate protein	Rattus norvegicus	119-130
7632609-2	1995	Vitamin D-binding protein (DBP), a multifunctional, highly polymorphic glycoprotein responsible for the transport of vitamin D and for sequestering extracellular actin, was isolated from human serum and crystallized using vapour diffusion methods.	Vitamin D	117-126	D-box binding PAR bZIP transcription factor	Homo sapiens	27-30
21153172-5	1995	We have investigated the relationship between the binding affinity for human DBP and the serum level and serum half-life (t(1/2)) in rats of a series of new vitamin D analogues.	Vitamin D	157-166	D-box binding PAR bZIP transcription factor	Homo sapiens	77-80
7626513-1	1995	The transporter of vitamin D and its metabolites in blood has received increasing attention in recent years, and is recognized to be a member of a gene family that includes albumin and alpha-fetoprotein.	Vitamin D	19-28	alpha fetoprotein	Homo sapiens	185-202
7626514-4	1995	The expressed hVDR displays strict dependence on the family of retinoid X receptors (RXRs) for binding to the vitamin D-responsive element (VDRE) in the rat osteocalcin gene.	Vitamin D	110-119	bone gamma-carboxyglutamate protein	Rattus norvegicus	157-168
7566512-1	1995	The regulation of cholecystokinin and somatostatin expression by vitamin D and cyclic AMP in the rat medullary thyroid carcinoma cell line CA-77 was investigated.	Vitamin D	65-74	somatostatin	Rattus norvegicus	38-50
7611412-1	1995	The X-linked hypophosphatemic (Hyp) mouse is a model for hypophosphatemic vitamin D-resistant rickets and is a homologue of human X-linked hypophosphatemia.	Vitamin D	74-83	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	31-34
7598807-4	1995	As well as containing a vitamin D response element, the upstream region of the osteocalcin promoter also has potent basal activity in the osteoblast-like ROS17/2.8 cell line.	Vitamin D	24-33	bone gamma-carboxyglutamate protein	Rattus norvegicus	79-90
7751997-8	1995	During vitamin D treatment, serum 1,25(OH)2D values increased to supranormal concentrations in association with the restoration of the physiologic relationship of PTH to serum calcium and phosphate concentrations and urinary cAMP/creatinine ratio.	Vitamin D	7-16	parathyroid hormone	Homo sapiens	163-166
7530647-11	1995	With vitamin D present, osteocalcin levels were 4 times higher in the medium of strained cells compared to nonstrained controls.	Vitamin D	5-14	bone gamma-carboxyglutamate protein	Homo sapiens	24-35
7752465-1	1995	The synthesis of human parathyroid hormon (PTH) is controlled by extracellular Ca2+ concentration and 1,25 (OH)2D3, independently, nCaRE (negative calcium responsive element) and nVDRE (negative vitamin D responsive element) have been detected on 5" flanking region of human PTH gene.	Vitamin D	195-204	parathyroid hormone	Homo sapiens	43-46
7714065-4	1995	The measurements were repeated in 283 women after 1 yr and in 248 women after 2 yr. Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D (250HD) (+35 nmol/L) and 1,25-dehydroxyvitamin D [1,25-(OH)2D] (+7.0 pmol/L) levels and urinary calcium/creatinine ratios (+0.5%) and significantly decreased PTH(1-84) secretion (-0.74 pmol/L) after 1 yr. No effect was found for the parameters of bone turnover.	Vitamin D	84-93	parathyroid hormone	Homo sapiens	318-321
7708726-3	1995	Most important, the two specific complexes formed by porcine nuclear extract with the vitamin D response elements from either the osteocalcin gene or the rat 24-hydroxylase gene are shifted to a larger complex by both an anti-vitamin D receptor antibody and an anti-RXR antibody, leaving no doubt that in vivo the nuclear accessory factor for the vitamin D receptor in the intestine is an RXR protein.	Vitamin D	86-95	bone gamma-carboxyglutamate protein	Rattus norvegicus	130-141
7736316-0	1995	Serum intact parathyroid hormone in a random population sample of men and women: relationship to anthropometry, life-style factors, blood pressure, and vitamin D.	Vitamin D	152-161	parathyroid hormone	Homo sapiens	13-32
7626415-2	1995	Calbindin-D9k, calbindin-D28k and osteocalcin are presented as the most-extensively investigated vitamin D-dependent calcium-binding proteins.	Vitamin D	97-106	S100 calcium binding protein G	Homo sapiens	0-13
7626415-2	1995	Calbindin-D9k, calbindin-D28k and osteocalcin are presented as the most-extensively investigated vitamin D-dependent calcium-binding proteins.	Vitamin D	97-106	bone gamma-carboxyglutamate protein	Homo sapiens	34-45
7897874-0	1995	[Extraction and purification of the three major vitamin D metabolites using C18 and NH2 cartridges and measurement of 25-hydroxyvitamin D].	Vitamin D	48-57	Bardet-Biedl syndrome 9	Homo sapiens	76-79
7813631-9	1995	Although differentiation-related genes (alkaline phosphatase and osteocalcin) were up-regulated by vitamin D, culture on the collagen matrix could not overcome the inhibition of mineralization.	Vitamin D	99-108	bone gamma-carboxyglutamate protein	Rattus norvegicus	65-76
7731147-1	1995	Recent studies suggest that secondary hyperparathyroidism and/or vitamin D deficiency are responsible for the insulin resistance in chronic renal failure.	Vitamin D	65-74	insulin	Homo sapiens	110-117
8546173-1	1995	Secondary hyperparathyroidism in patients with end-stage renal disease is characterised by elevated circulating levels of parathyroid hormone, due to inadequate synthesis of calcitriol, the active metabolite of vitamin D.	Vitamin D	211-220	parathyroid hormone	Homo sapiens	122-141
7731147-6	1995	Intravenous vitamin D treatment led to a significant reduction of parathyroid hormone levels and to a complete normalization of insulin sensitivity in the hemodialysis patients.	Vitamin D	12-21	insulin	Homo sapiens	128-135
7897874-1	1995	In this study, the three major vitamin D metabolites: 25-hydroxyvitamin D [25(OH)D], 24,25-dihydroxy-vitamin D [24,25(OH)2D], 1,25-dihydroxyvitamin D [1,25(OH)2D] were clearly separated using a NH2 cartridge after acetonitrile and C18 cartridge extraction.	Vitamin D	31-40	Bardet-Biedl syndrome 9	Homo sapiens	231-234
7530313-1	1995	Alpha-fetoprotein (AFP) is an oncofetal protein classified in a super-family together with albumin and Vitamin-D binding (Gc) protein which present as globular proteins comprised of three domains.	Vitamin D	103-112	alpha fetoprotein	Homo sapiens	0-17
7530313-1	1995	Alpha-fetoprotein (AFP) is an oncofetal protein classified in a super-family together with albumin and Vitamin-D binding (Gc) protein which present as globular proteins comprised of three domains.	Vitamin D	103-112	alpha fetoprotein	Homo sapiens	19-22
7890807-5	1994	A 41 bp fragment from this region (between nucleotides -2256 and -2216) contains a sequence which is very similar to vitamin D-responsive elements identified in the osteocalcin gene.	Vitamin D	117-126	bone gamma-carboxyglutamate protein	Homo sapiens	165-176
7809144-0	1994	In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells.	Vitamin D	25-34	bone gamma-carboxyglutamate protein	Rattus norvegicus	61-72
7809144-0	1994	In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells.	Vitamin D	87-96	bone gamma-carboxyglutamate protein	Rattus norvegicus	61-72
7809144-6	1994	Our results establish in intact cells the requirement for both ligand- and receptor-dependent occupancy of the VDRE for vitamin D responsive enhancement of osteocalcin gene transcription.	Vitamin D	120-129	bone gamma-carboxyglutamate protein	Rattus norvegicus	156-167
7872065-0	1994	Activation of the human osteocalcin gene by 24R,25-dihydroxyvitamin D3 occurs through the vitamin D receptor and the vitamin D-responsive element.	Vitamin D	60-69	bone gamma-carboxyglutamate protein	Homo sapiens	24-35
7872065-1	1994	1 alpha-25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], together with vitamin D receptor (VDR), directly activates human osteocalcin (hOC) gene expression through a vitamin D-responsive element (VDRE) located in the promoter of the hOC gene.	Vitamin D	20-29	bone gamma-carboxyglutamate protein	Homo sapiens	117-128
7565453-4	1995	Significant correlations were observed between the dietary vitamin D intake and the plasma 25-OH-D or HS-PTH levels.	Vitamin D	59-68	parathyroid hormone	Homo sapiens	105-108
7565453-6	1995	These results suggest that dietary intake of sufficient amounts of vitamin D is effective for improving the vitamin D nutritional status through normalizing PTH levels.	Vitamin D	67-76	parathyroid hormone	Homo sapiens	157-160
7478147-4	1995	In at least some studies high dose intermittent bolus administration of vitamin D can reduce parathyroid hormone (PTH) secretion by a mechanism separated in time from an increase in ionized calcium (iCa2+).	Vitamin D	72-81	parathyroid hormone	Homo sapiens	93-112
7478147-4	1995	In at least some studies high dose intermittent bolus administration of vitamin D can reduce parathyroid hormone (PTH) secretion by a mechanism separated in time from an increase in ionized calcium (iCa2+).	Vitamin D	72-81	parathyroid hormone	Homo sapiens	114-117
7890807-8	1994	These results indicate that a vitamin D response element similar to that described for other vitamin D responsive genes (osteocalcin and osteopontin) does not alone mediate the repression of COL1A1 by 1,25-dihydroxyvitamin D3.	Vitamin D	30-39	bone gamma-carboxyglutamate protein	Homo sapiens	121-132
7890807-8	1994	These results indicate that a vitamin D response element similar to that described for other vitamin D responsive genes (osteocalcin and osteopontin) does not alone mediate the repression of COL1A1 by 1,25-dihydroxyvitamin D3.	Vitamin D	93-102	bone gamma-carboxyglutamate protein	Homo sapiens	121-132
7986828-0	1994	Vitamin D-dependent rickets type II: regulation of human osteocalcin gene expression in cells with defective vitamin D receptors by 1,25-dihydroxyvitamin D-3, retinoic acid, and triiodothyronine.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	57-68
7986828-1	1994	The vitamin D receptor (VDR) is a nuclear transcription factor which binds to the vitamin D response element (VDRE) of the human osteocalcin gene and regulates its expression.	Vitamin D	4-13	bone gamma-carboxyglutamate protein	Homo sapiens	129-140
7864359-1	1994	We describe a multiple assay of the three main vitamin D metabolites, 25OHD, 24,25(OH)2D, and 1,25(OH)2D, in 0.5 ml of serum, which does not require high-performance liquid chromatography.	Vitamin D	47-56	25OHD	Bos taurus	70-75
7956930-4	1994	RXR alpha-RF formed, like recombinant RXR alpha, heterodimers on DNA with vitamin D and retinoic acid but not estrogen receptors.	Vitamin D	74-83	retinoid X receptor alpha	Rattus norvegicus	0-9
7858486-6	1994	When GH was tested in combination with 1,25(OH)2D3, it tended to inhibit vitamin D-stimulated effects on differentiation markers but these effects were not statistically significant.	Vitamin D	73-82	growth hormone 1	Homo sapiens	5-7
7863823-1	1994	The mechanisms underlying the effects of recombinant human growth hormone (rhGH) on vitamin D, mineral, and bone metabolism are not known.	Vitamin D	84-93	growth hormone 1	Homo sapiens	59-73
8076631-1	1994	The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines.	Vitamin D	97-106	bone gamma-carboxyglutamate protein	Homo sapiens	161-172
8076631-1	1994	The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines.	Vitamin D	97-106	bone gamma-carboxyglutamate protein	Homo sapiens	199-210
8076631-12	1994	These results suggest that AP-1 interferes with VDR binding to the AP-1 + VDRE element and that the vitamin D responsiveness of the osteocalcin gene correlates with weak AP-1 binding and strong binding of the faster migrating VDR complex.	Vitamin D	100-109	bone gamma-carboxyglutamate protein	Homo sapiens	132-143
7922786-0	1994	Modulation of vitamin D increased H2O2 production and MAC-2 expression in the bone marrow-derived macrophages by estrogen.	Vitamin D	14-23	lectin, galactose binding, soluble 3	Mus musculus	54-59
7953986-1	1994	Carboxyterminal propeptide of type I procollagen (PICP) was measured in sera from 25 patients with osteomalacia due to privational vitamin D deficiency.	Vitamin D	131-140	collagen type I alpha 2 chain	Homo sapiens	30-48
7953986-4	1994	The normalization of serum PICP and ALP, indicating a healing process of the bone disorder, needed longer time of vitamin D and calcium therapy.	Vitamin D	114-123	alkaline phosphatase, placental	Homo sapiens	36-39
7953986-6	1994	Serum PICP and total ALP appeared to behave differently in the disease and in its response to vitamin D therapy suggesting that these two markers may represent different functions of osteoblasts in osteomalacia.	Vitamin D	94-103	alkaline phosphatase, placental	Homo sapiens	21-24
7962175-0	1994	Regulation of TNF-alpha release from bone marrow-derived macrophages by vitamin D.	Vitamin D	72-81	tumor necrosis factor	Mus musculus	14-23
11539512-9	1994	Interestingly, TGF-beta is increased by estrogen(E2), androgen, vitamin D, TGF-beta and FGF.	Vitamin D	64-73	transforming growth factor beta 1	Homo sapiens	15-23
8170472-0	1994	The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element.	Vitamin D	29-38	zinc fingers and homeoboxes 2	Homo sapiens	86-111
8194478-0	1994	Inhibition of 1,25-dihydroxyvitamin D3 stimulated osteocalcin gene transcription by tumor necrosis factor-alpha: structural determinants within the vitamin D response element.	Vitamin D	28-37	bone gamma-carboxyglutamate protein	Rattus norvegicus	50-61
8194478-0	1994	Inhibition of 1,25-dihydroxyvitamin D3 stimulated osteocalcin gene transcription by tumor necrosis factor-alpha: structural determinants within the vitamin D response element.	Vitamin D	28-37	tumor necrosis factor	Rattus norvegicus	84-111
8089197-0	1994	Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells.	Vitamin D	14-23	bone gamma-carboxyglutamate protein	Homo sapiens	84-95
8089197-1	1994	Vitamin D responsive transcription of the bone-specific osteocalcin gene differs markedly in osteosarcoma cells and normal diploid osteoblasts.	Vitamin D	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	56-67
8089197-2	1994	In osteoblasts the osteocalcin gene is transcribed, and upregulated by Vitamin D, only in post-proliferative cells, but in osteosarcoma cells expression is constitutive.	Vitamin D	71-80	bone gamma-carboxyglutamate protein	Homo sapiens	19-30
8089197-3	1994	This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter.	Vitamin D	156-165	bone gamma-carboxyglutamate protein	Homo sapiens	54-65
8089197-3	1994	This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter.	Vitamin D	156-165	bone gamma-carboxyglutamate protein	Homo sapiens	262-273
8089197-3	1994	This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter.	Vitamin D	226-235	bone gamma-carboxyglutamate protein	Homo sapiens	54-65
8089197-3	1994	This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter.	Vitamin D	226-235	bone gamma-carboxyglutamate protein	Homo sapiens	262-273
8089197-5	1994	Pore size exclusion and sedimentation velocity analyses suggest that the V1 and V2 complexes represent oligomeric protein assemblies (respectively, tetramers and trimers), and reflect primarily DNA-directed association of the monomeric protein components at the osteocalcin Vitamin D responsive element.	Vitamin D	274-283	bone gamma-carboxyglutamate protein	Homo sapiens	262-273
8089197-6	1994	UV crosslinking and methylation interference analyses of the V1 and V2 complexes at the osteocalcin Vitamin D responsive element indicate differences in protein/DNA recognition.	Vitamin D	100-109	bone gamma-carboxyglutamate protein	Homo sapiens	88-99
8089197-8	1994	Our findings suggest variations in protein/protein and protein/DNA interactions of the VDR and RXR related complexes V1 and V2 at the osteocalcin Vitamin D responsive element that reflect unique properties of the osteosarcoma and normal diploid osteoblast phenotype.	Vitamin D	146-155	bone gamma-carboxyglutamate protein	Homo sapiens	134-145
7522654-2	1994	AFP and SA exhibit a reciprocal relation during development and carry mostly fatty acids, while DBP carries vitamin D and its metabolites in the plasma.	Vitamin D	108-117	D-box binding PAR bZIP transcription factor	Homo sapiens	96-99
7522654-10	1994	The physiological role of AFP and SA would be to mediate the transfer of fatty acids into cells, while that of DBP would be to facilitate the intracellular delivery of vitamin D.	Vitamin D	168-177	D-box binding PAR bZIP transcription factor	Homo sapiens	111-114
7959906-4	1994	All three vitamin D derivatives counteracted the suppressive effect of IL-1 beta on medium insulin accumulation, 1,25-(OH)2D3 being active at concentrations down to 0.1 nM, i.e., 1-2 orders of magnitude more efficacious than the analogues.	Vitamin D	10-19	interleukin 1 beta	Rattus norvegicus	71-80
7959906-4	1994	All three vitamin D derivatives counteracted the suppressive effect of IL-1 beta on medium insulin accumulation, 1,25-(OH)2D3 being active at concentrations down to 0.1 nM, i.e., 1-2 orders of magnitude more efficacious than the analogues.	Vitamin D	10-19	insulin	Homo sapiens	91-98
8144641-1	1994	The 5"-flanking region of the rat vitamin D3 24-hydroxylase (P450cc24) gene was examined and a vitamin D-responsive element (VDRE) responsible for the 1 alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) enhancement was identified.	Vitamin D	34-43	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	61-69
8144641-8	1994	These results indicate that a direct repeat motif, AGGTGAgt-gAGGGCG, located at -151 base pairs upstream in the antisense strand binds to a heterologous dimer consisting of the VDR occupied with 1,25-(OH)2D3 and the nuclear accessory factor and that it plays a critical role in mediating the vitamin D enhancement of the rat P450cc24 gene expression.	Vitamin D	292-301	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	325-333
7510956-0	1994	Topoisomerase I-inhibition enhances vitamin D-responsive expression of the receptor for lipopolysaccharide binding protein CD 14.	Vitamin D	36-45	CD14 molecule	Homo sapiens	123-128
8126128-7	1994	These results suggest that chronic and profound hypocalcemia and/or vitamin D deficiency can stimulate endogenous PTHrP secretion via a negative feedback mechanism, although elevated iPTHrP does not normalize the decreased serum calcium levels.	Vitamin D	68-77	parathyroid hormone like hormone	Homo sapiens	114-119
8015545-4	1994	However, we have previously shown that a closely related, but distinct, element (AGTTCA; essentially the mouse osteopontin [Spp-1] vitamin D response element) acts as a high affinity target for purified hVDR in the absence of RXR.	Vitamin D	131-140	secreted phosphoprotein 1	Mus musculus	111-122
8015545-4	1994	However, we have previously shown that a closely related, but distinct, element (AGTTCA; essentially the mouse osteopontin [Spp-1] vitamin D response element) acts as a high affinity target for purified hVDR in the absence of RXR.	Vitamin D	131-140	secreted phosphoprotein 1	Mus musculus	124-129
8170473-1	1994	In this report we confirm that the putative vitamin D response element (VDRE), located between -320 and -306 in the chicken calbindin-D28K gene, is not a binding site for the vitamin D3 receptor (VDR).	Vitamin D	44-53	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	72-75
8391878-4	1993	1,25-Dihydroxyvitamin D3, another monocyte/macrophage-inducer, abated either TPA- or dbcAMP-stimulated synthesis and release of HGF in a dose-dependent manner probably via its nuclear receptor as reflected by vitamin D analog study.	Vitamin D	14-23	hepatocyte growth factor	Homo sapiens	128-131
8012094-5	1993	Vitamin D should not be administered to patients with malignancy-associated hypercalcemia, particularly that due to PTHrP-producing tumors.	Vitamin D	0-9	parathyroid hormone like hormone	Homo sapiens	116-121
8225199-7	1993	Therefore the calcitonin gene is regulated by vitamin D and estrogens, but not by calcium.	Vitamin D	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	14-24
8505313-3	1993	The immune complex phosphatase assay using the antibody demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) and a vitamin D metabolite increased the PTP activity of immunoprecipitated PTP1C to 230 and 150% of control, respectively.	Vitamin D	123-132	protein tyrosine phosphatase receptor type U	Homo sapiens	158-161
8170472-1	1994	The human vitamin D receptor (hVDR) requires another nuclear protein(s), designated receptor auxiliary factor (RAF), for optimal binding to the vitamin D-responsive element (VDRE).	Vitamin D	10-19	zinc fingers and homeoboxes 2	Homo sapiens	84-109
8419116-5	1993	In the vitamin D-deficient animals, serum PTH levels slightly, but not significantly, increased, and the levels of vitamin D metabolites abruptly fell.	Vitamin D	7-16	parathyroid hormone	Oryctolagus cuniculus	42-45
8395017-1	1993	The vitamin D receptor (VDR) binds the vitamin D-responsive element (VDRE) as a heterodimer with an unidentified receptor auxiliary factor (RAF) present in mammalian cell nuclear extracts.	Vitamin D	4-13	zinc fingers and homeoboxes 2	Homo sapiens	140-143
8170472-1	1994	The human vitamin D receptor (hVDR) requires another nuclear protein(s), designated receptor auxiliary factor (RAF), for optimal binding to the vitamin D-responsive element (VDRE).	Vitamin D	10-19	zinc fingers and homeoboxes 2	Homo sapiens	111-114
8302863-0	1994	Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene.	Vitamin D	20-29	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	69-105
22217851-7	1992	1,25-Dihydroxyvitamin D, the active metabolite of vitamin D, markedly stimulates renal P450cc24 mRNA and 24-hydroxylase activity in the intact animal and in renal cell lines.	Vitamin D	14-23	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	87-95
1360744-0	1992	Regulation of calcitonin gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat.	Vitamin D	77-86	calcitonin-related polypeptide alpha	Rattus norvegicus	14-24
1318720-2	1992	This study examined whether 1,25-(OH)2D3 regulates CaBP gene transcription by an interaction of the vitamin D receptor (VDR) with a vitamin D-responsive element (VDRE) in the CaBP promoter.	Vitamin D	100-109	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	120-123
1360744-2	1992	We now report the effect of chronic hypercalcemia, hypocalcemia, and vitamin D deficiency on calcitonin gene expression in vivo in the rat.	Vitamin D	69-78	calcitonin-related polypeptide alpha	Rattus norvegicus	93-103
8389284-5	1993	Vitamin D treatment when combined with a high level of dietary calcium resulted in an increase in plasma calcium from 6 mg/dl to greater than 10 mg/dl, a decrease in PTH mRNA of 65%, and a 6- to 8-fold increase in VDR mRNA.	Vitamin D	0-9	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	214-217
1324053-10	1992	It is concluded that, besides sharing the hypotensive effect of calcium, vitamin D treatment of SHR has an effect on the duodenum smooth muscle which might be due to calmodulin-dependent activation of calcium-dependent potassium channels.	Vitamin D	73-82	calmodulin 1	Rattus norvegicus	166-176
7681765-3	1993	In primary cultures of rat renal tubular cells, 1,25-(OH)2D3 produced a 26-fold increase in P450cc24 mRNA which was detectable at 4 h, maximal at 24 h, and returned almost to baseline by 48 h. The induction was inhibited by actinomycin D, 5,6-dichloro-1-b-D-ribofuranosyl benzimidazole (DRB), and cycloheximide, and it was specific for vitamin D compounds containing a 1-hydroxyl group.	Vitamin D	336-345	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	92-100
1376958-0	1992	Dietary restriction of calcium, phosphorus, and vitamin D elicits differential regulation of the mRNAs for avian intestinal calbindin-D28k and the 1,25-dihydroxyvitamin D3 receptor.	Vitamin D	48-57	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	147-180
1508945-4	1992	Growth hormone, which has been shown to affect intestinal Ca absorption and vitamin D metabolism, is thought to act indirectly by stimulating IGF-I.	Vitamin D	76-85	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
1661245-6	1991	The retinoic acid response element (RARE) for the rat growth hormone gene is also a thyroid hormone response element (TRE), and the AP-1 binding site of the human osteocalcin promoter is also a vitamin D response element (VDRE) and a RARE.	Vitamin D	194-203	gonadotropin releasing hormone receptor	Rattus norvegicus	54-68
8410379-1	1993	Messenger ribonucleic acid (mRNA) levels and activities of renal 25-hydroxyvitamin D3-24-hydroxylase (24-OHase) were determined in 3 groups of rats: vitamin D-deficient, normal, and 1 alpha-hydroxyvitamin D3 (1 alpha OHD3)-administered rats.	Vitamin D	75-84	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	102-110
2224592-1	1990	Vitamin D and its metabolites are tightly bound to the serum vitamin D-binding protein (DBP) and only the free hormone is considered to be physiologically active.	Vitamin D	0-9	GC, vitamin D binding protein	Rattus norvegicus	61-86
1727425-1	1992	For the quantitative analysis of vitamin D-dependent 28-kDa calcium-binding protein (calbindin-D) in the CNS, we have established a highly sensitive immunoassay method.	Vitamin D	33-42	calbindin	Oryctolagus cuniculus	85-94
1314319-0	1992	Induction of the fms proto-oncogene product in HL-60 cells by vitamin D: a flow cytometric analysis.	Vitamin D	62-71	colony stimulating factor 1 receptor	Homo sapiens	17-35
8410379-7	1993	In vitamin D-deficient rats, renal 25-hydroxyvitamin D3-1 alpha-hydroxylase activity was markedly elevated and 24-OHase activity was completely abolished.	Vitamin D	3-12	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	111-119
1985037-1	1991	A myosinlike 105-110-kilodalton calmodulin-binding protein, brush border myosin I, found in the intestinal brush border has been linked to two seemingly disparate but possibly interacting functions of the brush border, namely, microvillar motility and vitamin D regulated calcium transport.	Vitamin D	252-261	myosin IA	Homo sapiens	60-81
1662118-3	1991	This protein, termed RXR beta, forms heterodimers with RAR, preferentially increasing its DNA binding and transcriptional activity on promoters containing retinoic acid, but not thyroid hormone or vitamin D, response elements.	Vitamin D	197-206	retinoid X receptor beta	Homo sapiens	21-29
2142491-13	1990	This suggests that LHRH agonists may induce a change in other pituitary hormones involved in vitamin D regulation.	Vitamin D	93-102	gonadotropin releasing hormone 1	Homo sapiens	19-23
1985037-3	1991	On the other hand, a more specialized function such as participation in vitamin D regulated calcium transport might dictate a more restricted tissue distribution for brush border myosin I.	Vitamin D	72-81	myosin IA	Homo sapiens	166-187
33237074-9	2020	Vitamin D deficiency also lowered the placental protein levels of pro-angiogenic proteins VEGF and Flt-1 (p < 0.05 and p < 0.01, respectively), while the levels of these proteins in the VDS-PE group were similar to those in the control group.	Vitamin D	0-9	Fms related receptor tyrosine kinase 1	Rattus norvegicus	99-104
33237074-11	2020	CONCLUSION: A low dose vitamin D supplementation given from pre-pregnancy and throughout pregnancy was beneficial in reducing the blood pressure and normalizing the placental levels of VEGF and Flt-1.	Vitamin D	23-32	Fms related receptor tyrosine kinase 1	Rattus norvegicus	194-199
1761574-2	1991	The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), produced a concentration-dependent reduction in the synthesis of aggrecan as monitored by histochemical staining of the matrix, incorporation of [35S]sulfate, and the level of aggrecan core protein.	Vitamin D	25-34	aggrecan	Rattus norvegicus	252-273
1665202-5	1991	We find that the VDRF protein binds strongly and specifically to direct repeats constituting a vitamin D response element from the mouse osteopontin (Spp-1) promoter region but weakly to the human osteocalcin vitamin D response element.	Vitamin D	95-104	secreted phosphoprotein 1	Mus musculus	137-148
32322939-5	2020	PH was defined as hypoparathormonemia (<=12 pg/mL) or the need for calcium/vitamin D supplementation to achieve normal calcium levels for more than 12 months.	Vitamin D	75-84	phenylalanine hydroxylase	Homo sapiens	0-2
1665202-5	1991	We find that the VDRF protein binds strongly and specifically to direct repeats constituting a vitamin D response element from the mouse osteopontin (Spp-1) promoter region but weakly to the human osteocalcin vitamin D response element.	Vitamin D	95-104	secreted phosphoprotein 1	Mus musculus	150-155
33816359-4	2021	Vitamin D may be protective against acute respiratory tract infections, as it regulates the inflammatory cytokine response of respiratory epithelial cells and macrophages, suppress CS and other manifestations seen in SARS-Cov-2.	Vitamin D	0-9	citrate synthase	Homo sapiens	181-183
2036965-1	1991	The mouse kidney is a unique tissue since both vitamin D-dependent calcium binding proteins (calbindin-D9k and calbindin-D28k) are present in the same cells of the distal convoluted tubule.	Vitamin D	47-56	S100 calcium binding protein G	Mus musculus	93-106
28083039-6	2016	Dependent sample t-test was used to see the significant effect of vitamin D supplementation on pre- intervention vitamin D levels, 6MWD and Pro-BNP.	Vitamin D	66-75	natriuretic peptide B	Homo sapiens	144-147
28083039-12	2016	CONCLUSION: Vitamin D supplementation decreases the severity of HF as reflected by reduction in serum pro-BNP levels and significant increase in six minutes" walk distance.	Vitamin D	12-21	natriuretic peptide B	Homo sapiens	106-109
33767430-9	2021	These findings suggest that macrophages harbour a vitamin D-primed innate defence mechanism, involving CRIg.	Vitamin D	50-59	V-set and immunoglobulin domain containing 4	Homo sapiens	103-107
34657267-0	2022	Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model.	Vitamin D	10-19	TNF superfamily member 11	Rattus norvegicus	43-48
2174892-5	1990	The purified VDR associated with a specific synthetic DNA sequence comprising the vitamin D response element as assayed through bandshift analysis.	Vitamin D	82-91	vitamin D3 receptor	Oryctolagus cuniculus	13-16
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interleukin 5	Homo sapiens	263-267
2174892-8	1990	These studies, together with our previous experiments that demonstrate reconstitution of a vitamin D-dependent transcription system in yeast, show that the VDR can be produced and purified from yeast in a functional form.	Vitamin D	91-100	vitamin D3 receptor	Oryctolagus cuniculus	156-159
34919268-3	2022	This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency.	Vitamin D	167-176	glutamyl aminopeptidase	Homo sapiens	107-110
2394711-2	1990	MGP is also expressed at high levels in heart, kidney, and lung and is up-regulated by vitamin D in bone cells.	Vitamin D	87-96	matrix Gla protein	Homo sapiens	0-3
34758675-8	2021	CONCLUSION: Vitamin D-related improvement of insulin signalling and insulin regulation of glucose metabolism in the rat heart is accompanied by the decrease of blood NEFA level and dysregulation of cardiac FOXO1 signalling.	Vitamin D	12-21	forkhead box O1	Rattus norvegicus	206-211
34460994-15	2021	Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level.	Vitamin D	153-162	transforming growth factor, beta 1	Mus musculus	93-102
34536747-0	2021	Role of vitamin D/VDR nuclear translocation in down-regulation of NF-kappaB/NLRP3/caspase-1 axis in lupus nephritis.	Vitamin D	8-17	caspase 1	Mus musculus	82-91
34950826-5	2021	The requirement for a vitamin D receptor for the photoprotective actions of 1,25(OH)2D3 and of naturally occurring CYP11A1-derived vitamin D-related compounds may explain why mice lacking the vitamin D receptor in skin are more susceptible to UV-induced skin cancers, whereas mice lacking the 1alpha-hydroxylase and thus unable to make 1,25(OH)2D3 are not more susceptible.	Vitamin D	131-140	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	115-122
34185245-0	2021	Vitamin D promotes autophagy in AML cells by inhibiting miR-17-5p-induced Beclin-1 overexpression.	Vitamin D	0-9	microRNA 17	Homo sapiens	56-65
33234810-8	2021	RESULTS: Patients with vitamin D deficency had higher values of Alx@75 and PWV values (20.9 +- 9 vs. 16.8 +- 6.9, P = 0.018 and 8.37 +- 1.16 vs. 6.9 +- 0.9, P = 0.001, respectively) despite similar 24-hour ambulatory BP monitoring in both groups.	Vitamin D	23-32	hematopoietic SH2 domain containing	Homo sapiens	64-67
33234810-11	2021	CONCLUSION: Vitamin D deficiency is associated with increased arterial stiffness in newly diagnosed hypertensive patients in terms of increased PWV and Alx@75 values.	Vitamin D	12-21	hematopoietic SH2 domain containing	Homo sapiens	152-155
34185245-8	2021	Finally, through rescue assays, miR-17-5p facilitated the ability of cell proliferation, inhibited autophagy and apoptosis by modulating Beclin-1 in HL-60 cells following the treatment of 4 muM vitamin D.	Vitamin D	194-203	microRNA 17	Homo sapiens	32-41
34680413-7	2021	We demonstrated that a combination of butyrate and active vitamin D (1 alpha, 25-dihydroxyvitamin D3) synergically reduced the severity of Salmonella colitis in C57BL/6 mice and reduced cecal inflammatory mIL-6, mIL-8, mTNF-alpha, and mIL-1beta mRNA expression, but enhanced the antimicrobial peptide mhBD-3 mRNA, compared to a single treatment.	Vitamin D	58-67	chemokine (C-X-C motif) ligand 15	Mus musculus	212-217
34185245-9	2021	Vitamin D promoted autophagy in AML cells by modulating miR-17-5p and Beclin-1.	Vitamin D	0-9	microRNA 17	Homo sapiens	56-65
34388585-4	2021	METHODS: First, to evaluate the physiological conditions required for MBP activity, we examined the bone and mineral phenotypes of mice that suffer from insufficient calcium absorption due to a lack of intestinal vitamin D signaling.	Vitamin D	213-222	myelin basic protein	Mus musculus	70-73
34731356-1	2022	Endocrine and paracrine fibroblast growth factor 23 (FGF23) is a protein predominantly produced by bone cells with strong impact on phosphate and vitamin D metabolism by targeting the kidney.	Vitamin D	146-155	fibroblast growth factor 23	Rattus norvegicus	24-51
34731356-1	2022	Endocrine and paracrine fibroblast growth factor 23 (FGF23) is a protein predominantly produced by bone cells with strong impact on phosphate and vitamin D metabolism by targeting the kidney.	Vitamin D	146-155	fibroblast growth factor 23	Rattus norvegicus	53-58
34621292-12	2021	We also discovered a novel association in a SNP downstream of CYP2J2 (rs10789082), a gene involved in 25-hydroxylation of vitamin D, with vitamin D in pregnant women (Beta=-7.68/G-allele, p=1.5x10-8), but not their offspring.	Vitamin D	122-131	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	62-68
34948139-8	2021	Moreover, oral therapy with active forms of vitamin D suppressed arthritis in LAIR-1 sufficient DR1 mice, but were ineffective in LAIR-1-/- deficient mice.	Vitamin D	44-53	down-regulator of transcription 1	Mus musculus	96-99
34821697-1	2021	Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system.	Vitamin D	0-9	renin	Rattus norvegicus	87-92
34842603-5	2021	The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former.	Vitamin D	40-49	interleukin 33	Homo sapiens	107-112
34842603-5	2021	The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former.	Vitamin D	40-49	interleukin 37	Homo sapiens	114-119
34842603-5	2021	The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former.	Vitamin D	167-176	interleukin 33	Homo sapiens	107-112
34842603-5	2021	The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former.	Vitamin D	167-176	interleukin 37	Homo sapiens	114-119
34842603-8	2021	Taken together, the results of this study suggest that modulating expression of IL-33, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs with vitamin D supplementation may serve as a novel therapeutic to attenuate inflammation and cartilage degeneration in osteoarthritis.	Vitamin D	131-140	interleukin 33	Homo sapiens	80-85
34917354-2	2022	Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-beta signaling pathway.	Vitamin D	93-102	transforming growth factor alpha	Homo sapiens	131-139
34621292-12	2021	We also discovered a novel association in a SNP downstream of CYP2J2 (rs10789082), a gene involved in 25-hydroxylation of vitamin D, with vitamin D in pregnant women (Beta=-7.68/G-allele, p=1.5x10-8), but not their offspring.	Vitamin D	138-147	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	62-68
34546511-2	2022	Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7alpha-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain.	Vitamin D	45-54	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	192-199
34643152-0	2021	25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFbeta-mediated nuclear translocation mechanism of YAP/TAZ.	Vitamin D	7-16	transforming growth factor alpha	Homo sapiens	73-80
34679063-5	2021	Here, we aimed to study the regulatory effects of Gal-3 on vitamin-D-regulated osteoclastogenesis and bone resorption in chicken.	Vitamin D	59-68	galectin 3	Gallus gallus	50-55
34458299-0	2021	The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-beta Dependent: A Proposed Anti-inflammatory Role in Airway Disease.	Vitamin D	40-49	transforming growth factor alpha	Homo sapiens	70-78
34721296-0	2021	Overlapping Phenotypes Associated With CYP24A1, SLC34A1, and SLC34A3 Mutations: A Cohort Study of Patients With Hypersensitivity to Vitamin D.	Vitamin D	132-141	solute carrier family 34 member 1	Homo sapiens	48-55
34721296-1	2021	Mutations in CYP24A1 (vitamin D 24-hydroxylase) and SLC34A1 (renal phosphate transporter NPT2a) cause autosomal recessive Infantile Hypercalcemia type 1 and 2, illustrating links between vitamin D and phosphate metabolism.	Vitamin D	187-196	solute carrier family 34 member 1	Homo sapiens	52-59
34643152-0	2021	25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFbeta-mediated nuclear translocation mechanism of YAP/TAZ.	Vitamin D	7-16	Yes1 associated transcriptional regulator	Homo sapiens	125-128
34389701-11	2021	CONCLUSIONS: Daily consumption of vitamin D-fortified yogurt drink for 12 weeks resulted in an increase in circulating concentrations of SIRT1 and SIRT6 in T2D subjects and D+Ca-fortified yogurt drink was more in favor of SIRT6 increment.	Vitamin D	34-43	sirtuin 6	Homo sapiens	147-152
33825665-0	2021	TRPV1 channels as a newly identified target for vitamin D.	Vitamin D	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
34143450-6	2021	Torin-1 (5 mg/kg/day), an mTOR inhibitor, significantly decreased aortic medial calcification accompanied with decreased expression of osteogenic markers like osteopontin (OSP) and runt-related transcription factor 2 (RUNX2) and upregulation of smooth muscle 22alpha (SM22-alpha) in mice receiving high dose of Vitamin D (500 000 IU/kg/day).	Vitamin D	311-320	secreted phosphoprotein 1	Mus musculus	159-170
34143450-6	2021	Torin-1 (5 mg/kg/day), an mTOR inhibitor, significantly decreased aortic medial calcification accompanied with decreased expression of osteogenic markers like osteopontin (OSP) and runt-related transcription factor 2 (RUNX2) and upregulation of smooth muscle 22alpha (SM22-alpha) in mice receiving high dose of Vitamin D (500 000 IU/kg/day).	Vitamin D	311-320	secreted phosphoprotein 1	Mus musculus	172-175
34817518-2	2021	We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFalpha, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency.	Vitamin D	133-142	C1q and TNF related 9	Homo sapiens	80-86
34817518-2	2021	We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFalpha, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency.	Vitamin D	213-222	C1q and TNF related 9	Homo sapiens	80-86
34817518-6	2021	RESULTS: In this study, there was a significant difference in CTRP-9, TNFalpha, total thiol (TT), native thiol (NT), DIS (disulfide), TT/DIS, and NT/DIS levels in vitamin D groups (p<0.05).	Vitamin D	163-172	C1q and TNF related 9	Homo sapiens	62-68
34817518-8	2021	CONCLUSIONS: It was determined that vitamin D deficiency causes a significant decrease in CTRP-9 level and a significant increase in TNFalpha level, as well as an increase in thiol/disulfide hemostasis in favor of disulfide, which may be a risk factor for increased oxidative stress.	Vitamin D	36-45	C1q and TNF related 9	Homo sapiens	90-96
35524469-0	2022	Modulatory effects of vitamin D on IL-33/ST2 immune axis in Guillain-Barre syndrome...Quo Vadis?	Vitamin D	22-31	interleukin 33	Homo sapiens	35-40
35318258-9	2022	1alpha,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression.	Vitamin D	37-46	programmed cell death 1	Homo sapiens	129-134
35418365-8	2022	RESULTS: Our results suggest that (1) there is a relationship between vitamin D deficiency and the onset of BPPV and (2) hypovitaminosis correction is able to reduce both the number of patients relapsing and the number of relapses per patient.	Vitamin D	70-79	benign paroxysmal positional vertigo	Homo sapiens	108-112
35250286-2	2022	Saudi Arabia (SA) is a sunny region; however, ample amount of data reported the increased prevalence of vitamin D deficiency along with T2DM.	Vitamin D	104-113	acyl-CoA synthetase medium chain family member 3	Homo sapiens	14-16
35250286-3	2022	Thus, this study aimed to compare vitamin D deficiency between healthy and T2DM patients in SA, alongside with the risk factors associated with that.	Vitamin D	34-43	acyl-CoA synthetase medium chain family member 3	Homo sapiens	92-94
2596609-5	1989	In vitamin D-deficient rat animals, G6PD activity in the middle part of the villus was approximately 60% lower than in normal animals [10.05 +/- 0.35 vs. 3.95 +/- 0.26 (means +/- SE) A585.min-1.micron-3 X 10(5), P less than 0.001] with reduced NADPH utilization via the H2 pathway (8.39 +/- 0.49 vs. 2.73 +/- 0.43 A585.min-1.micron-3 X 10(5), P less than 0.001) but not the H1 pathway (1.65 +/- 0.17 vs. 1.22 +/- 0.19 A585.min-1.micron-3 X 10(5), P = NS).	Vitamin D	3-12	glucose-6-phosphate dehydrogenase	Rattus norvegicus	36-40
2596609-6	1989	Intraperitoneal administration of 1,25(OH)2D3 (500 pmol) to vitamin D-deficient animals resulted in increased G6PD activity within 30 min (4.09 +/- 0.38 vs. 5.51 +/- 0.39 A585.min-1.micron-3 X 10(5), P less than 0.05), attaining normal levels within 2 h. The H2 but not the H1 pathway of NADPH utilization increased significantly in response to 1,25(OH)2D3.	Vitamin D	60-69	glucose-6-phosphate dehydrogenase	Rattus norvegicus	110-114
2766482-2	1989	Recently, a new extracellular pool of unsaturated fatty acids including arachidonate has been found in relation to group-specific component (Gc), a vitamin D-binding plasma protein that sequesters monomeric G-actin.	Vitamin D	148-157	GC, vitamin D binding protein	Rattus norvegicus	115-147
2544409-3	1989	The present studies were undertaken to investigate the ability of EGF to accelerate the postnatal induction of the vitamin D-dependent intestinal calcium-binding protein, calbindin-D9k.	Vitamin D	115-124	epidermal growth factor like 1	Rattus norvegicus	66-69
2544409-15	1989	The mechanism of EGF"s action to stimulate calcium absorption appears to involve a maturation effect on the vitamin D-dependent pathway.	Vitamin D	108-117	epidermal growth factor like 1	Rattus norvegicus	17-20
2786849-3	1989	To examine this, we studied the effect of 1,25(OH)2D3 on VSMC growth and found that this substance suppressed VSMC [3H]thymidine uptake; furthermore, this vitamin D metabolite also suppressed the stimulatory effect of epidermal growth factor (EGF) on VSMC proliferation.	Vitamin D	155-164	epidermal growth factor like 1	Rattus norvegicus	218-241
2786849-3	1989	To examine this, we studied the effect of 1,25(OH)2D3 on VSMC growth and found that this substance suppressed VSMC [3H]thymidine uptake; furthermore, this vitamin D metabolite also suppressed the stimulatory effect of epidermal growth factor (EGF) on VSMC proliferation.	Vitamin D	155-164	epidermal growth factor like 1	Rattus norvegicus	243-246
2786849-4	1989	The concomitant presence of this substance appeared to be required for its action on VSMC growth since cells pretreated with the vitamin D metabolite for up to 72 hours and then washed of the substance grew normally and responded to EGF.	Vitamin D	129-138	epidermal growth factor like 1	Rattus norvegicus	233-236
2474048-1	1989	Vitamin D may regulate pituitary function, as there are selective effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on gene expression in clonal pituitary tumour cells, and on TRH-induced TSH release in normal rat pituitary cells in vitro.	Vitamin D	0-9	thyrotropin releasing hormone	Rattus norvegicus	177-180
3342744-3	1988	The developmental appearance of vitamin D-dependent calcium-binding protein (calbindin-D9k) and alkaline phosphatase was studied in oc mutant and normal mice from birth to weaning, as were serum concentrations of 25-hydroxyvitamin D3 (25OHD3), 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], calcium, and phosphorus.	Vitamin D	32-41	S100 calcium binding protein G	Mus musculus	77-90
33825665-3	2021	Our recent discovery that vitamin D is a partial agonist of the Transient Receptor Potential Vanilloid family 1 (TRPV1) channel may provide new insights as to how this important vitamin exerts its biological effects either independently or in addition to the nuclear vitamin D receptor.	Vitamin D	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-111
3586497-0	1987	Parathyroid hormone-stimulated calcium absorption in cTAL from vitamin D-deficient rabbits.	Vitamin D	63-72	parathyroid hormone	Oryctolagus cuniculus	0-19
33825665-3	2021	Our recent discovery that vitamin D is a partial agonist of the Transient Receptor Potential Vanilloid family 1 (TRPV1) channel may provide new insights as to how this important vitamin exerts its biological effects either independently or in addition to the nuclear vitamin D receptor.	Vitamin D	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
33825665-4	2021	In this review, we discuss the literature surrounding this apparent discrepancy in vitamin D signaling and compare vitamin D with known TRPV1 ligands with respect to their binding to TRPV1.	Vitamin D	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	183-188
33825665-5	2021	Furthermore, we provide evidence supporting the notion that this novel vitamin D/TRPV1 axis may explain some of the beneficial actions of this vitamin in disease states where TRPV1 expression and vitamin D deficiency are known to overlap.	Vitamin D	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
33825665-5	2021	Furthermore, we provide evidence supporting the notion that this novel vitamin D/TRPV1 axis may explain some of the beneficial actions of this vitamin in disease states where TRPV1 expression and vitamin D deficiency are known to overlap.	Vitamin D	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	175-180
33825665-5	2021	Furthermore, we provide evidence supporting the notion that this novel vitamin D/TRPV1 axis may explain some of the beneficial actions of this vitamin in disease states where TRPV1 expression and vitamin D deficiency are known to overlap.	Vitamin D	196-205	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
34857198-5	2021	Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications.	Vitamin D	18-27	progesterone immunomodulatory binding factor 1	Homo sapiens	214-250
34857198-5	2021	Novel findings of Vitamin D suggest that along with regulation of cell growth, neuroprotective and mood-stabilizing effects, it regulates the immune response also modulate cytokine Interleukin-6 (IL-6) by inducing progesterone-induced blocking factor (PIBF), given the IL-6 levels are considerably high in COVID-19 patients which increases the further complications.	Vitamin D	18-27	progesterone immunomodulatory binding factor 1	Homo sapiens	252-256
34558256-8	2021	An increase in TGF-beta levels was noted among patients using vitamin D supplementation, which may suggest a mechanism by which cholecalciferol may improve MS prognosis.	Vitamin D	62-71	transforming growth factor alpha	Homo sapiens	15-23
3710080-7	1986	Phospholipase A activity was low in homogenates of isolated cells and high in scrapings; this was reduced in intestinal scrapings of vitamin D-deficient rats.	Vitamin D	133-142	phospholipase A and acyltransferase 1	Rattus norvegicus	0-15
34502422-8	2021	Recently, it was shown that active vitamin D, i.e., 1,25-dihydroxyvitamin D or 1,25(OH)2D, was necessary to maintain Lgr5+ intestinal stem cells, actively cycling under physiological conditions.	Vitamin D	35-44	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	117-121
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	98-107	autophagy related 5	Mus musculus	52-56
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	165-174	autophagy related 5	Mus musculus	52-56
34445700-12	2021	Vitamin D defends against SARS-CoV-2 through a complex mechanism through interactions between the modulation of innate and adaptive immune reactions, ACE2 expression, and inhibition of the renin-angiotensin system (RAS).	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	150-154
34445632-2	2021	Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-beta1.	Vitamin D	10-19	transforming growth factor, beta 1	Mus musculus	85-94
34445632-2	2021	Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-beta1.	Vitamin D	21-26	transforming growth factor, beta 1	Mus musculus	85-94
34445632-3	2021	This study was designed to determine whether the noncalcemic vit D analog, 17,20S(OH)2pD, suppresses fibrosis and mediators of the TGF-beta1 pathway in the bleomycin (BLM) model of fibrosis.	Vitamin D	61-66	transforming growth factor, beta 1	Mus musculus	131-140
34445530-4	2021	The aim of this study was to evaluate the effect of vitamin D on the expression of IL-33, IL-37, macrophages, and caspase-1 in the neointimal tissue of coronary artery in Yucatan microswine with vitamin D deficient, sufficient, and supplemented status.	Vitamin D	52-61	interleukin 33	Homo sapiens	83-88
34445530-4	2021	The aim of this study was to evaluate the effect of vitamin D on the expression of IL-33, IL-37, macrophages, and caspase-1 in the neointimal tissue of coronary artery in Yucatan microswine with vitamin D deficient, sufficient, and supplemented status.	Vitamin D	52-61	interleukin 37	Homo sapiens	90-95
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	72-81	interleukin 33	Homo sapiens	24-29
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	72-81	interleukin 37	Homo sapiens	34-39
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	72-81	interleukin 33	Homo sapiens	295-300
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	264-273	interleukin 33	Homo sapiens	24-29
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	264-273	interleukin 37	Homo sapiens	34-39
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	264-273	interleukin 33	Homo sapiens	295-300
34445530-7	2021	Increased expression of IL-33 and IL-37 in the neointimal tissue of the vitamin D deficient, as compared to the sufficient and supplemented microswine, as revealed by histological evaluation and semi-quantitative analysis, suggested the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37.	Vitamin D	264-273	interleukin 37	Homo sapiens	305-310
34183042-14	2021	Vitamin D reduced the phospho-NF-kappaB/p65 expression in the TNF-alpha-treated NP cells.	Vitamin D	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	40-43
34175885-11	2021	Treatment of vitamin D deficiency may be an effective way to improve bone strength in AS patients with hip involvement.	Vitamin D	13-22	hedgehog interacting protein	Homo sapiens	103-106
34150829-0	2021	Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury.	Vitamin D	24-33	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	67-73
34080787-0	2021	Vitamin D and Vitamin D-binding protein and risk of bladder cancer: A nested case-control study in the Norwegian Janus Serum Bank Cohort.	Vitamin D	0-9	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	125-129
34065735-10	2021	Vitamin D increases the bioavailability and expression of ACE2, which may be responsible for trapping and inactivating the virus.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	58-62
34065735-13	2021	In conclusion, vitamin D defends the body against SARS-CoV-2 through a novel complex mechanism that operates through interactions between the activation of both innate and adaptive immunity, ACE2 expression, and inhibition of the RAS system.	Vitamin D	15-24	angiotensin converting enzyme 2	Homo sapiens	191-195
35526529-11	2022	ChIP assays demonstrated the presence of a vitamin D response element (VDRE) in the nestin promoter, and paricalcitol enhanced the binding of VDR to VDRE.	Vitamin D	43-52	nestin	Mus musculus	84-90
35510742-0	2022	The effect of vitamin D supplementation on outcomes following total hip or knee arthroplasty surgery: a rapid systematic review of current evidence.	Vitamin D	14-23	hedgehog interacting protein	Homo sapiens	68-71
35510742-1	2022	Purpose: Vitamin D deficiency has been linked to poorer outcomes following hip (THR) and knee (TKR) replacement.	Vitamin D	9-18	hedgehog interacting protein	Homo sapiens	75-78
35079976-6	2022	CONCLUSIONS: The production of calcitriol is compromised after elective hip replacement surgery, leading to reduced levels of active vitamin D in the serum.	Vitamin D	133-142	hedgehog interacting protein	Homo sapiens	72-75
35339636-9	2022	Vitamin D inhibited mesenchymal transition in MCs and suppressed thrombospondin-1 expression via vitamin D receptor/Smad3 competition, contributing to the marked reduction in peritoneal dissemination in vivo.	Vitamin D	0-9	SMAD family member 3	Homo sapiens	116-121
35418433-1	2022	OBJECTIVE: To assess the association of serum vitamin D (VD) levels and Helicobacter pylori (H. pylori) cytotoxic-associated gene A (CagA) seropositivity, and further explore potential effect modifiers in this association.	Vitamin D	46-55	S100 calcium binding protein A8	Homo sapiens	133-137
35406129-13	2022	Lack of vitamin D signaling increases mortality in a model of overactivation of the IR by impairing lipid metabolism.	Vitamin D	8-17	insulin receptor	Mus musculus	84-86
35366947-0	2022	Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia.	Vitamin D	0-9	fructose bisphosphatase 1	Mus musculus	20-24
35091320-1	2022	OBJECTIVES: Fibroblast growth factor 23 (FGF23) controls the production and degradation of biologically active vitamin D, 1,25(OH)2D3, and phosphate reabsorption in the kidney as a hormone synthesized by bone cells.	Vitamin D	111-120	fibroblast growth factor 23	Rattus norvegicus	12-39
35091320-1	2022	OBJECTIVES: Fibroblast growth factor 23 (FGF23) controls the production and degradation of biologically active vitamin D, 1,25(OH)2D3, and phosphate reabsorption in the kidney as a hormone synthesized by bone cells.	Vitamin D	111-120	fibroblast growth factor 23	Rattus norvegicus	41-46
35216422-5	2022	RESULTS: at 6 months, although vitamin D and/or calcium did not significantly increase serum calcium levels, vitamin D and calcium supplementation significantly worsened aorta and renal artery calcification in Abcc6-/- mice.	Vitamin D	109-118	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Mus musculus	210-215
35252193-4	2022	In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related gamma-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation.	Vitamin D	27-36	anoctamin 1	Rattus norvegicus	69-76
35205153-1	2022	Angiogenin (ANG), a multifunctional protein known to induce blood vessel formation, is a potential biomarker for cardiovascular diseases; however, whether it is affected by vitamin D supplementation is not known.	Vitamin D	173-182	angiogenin	Homo sapiens	0-10
35205153-9	2022	Vitamin D supplementation may modestly affect ANG levels.	Vitamin D	0-9	angiogenin	Homo sapiens	46-49
35132380-0	2022	Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling.	Vitamin D	15-24	CREB regulated transcription coactivator 2	Mus musculus	76-82
35434279-12	2022	Finally, vitamin D supplementation for 10 weeks to AVD-deficient mice restored nNOS immunoreactivity to that seen in in control mice.	Vitamin D	9-18	nitric oxide synthase 1, neuronal	Mus musculus	79-83
35057792-13	2022	Activated MLPH + /CD206 + M2 macrophages secreted TGF-beta1 and are sensitive to Vitamin D treatment.	Vitamin D	81-90	transforming growth factor, beta 1	Mus musculus	50-59
35045292-5	2022	We show that JAK2-mediated STAT3 phosphorylation is specific to vitamin D stimulation.	Vitamin D	64-73	Janus kinase 2	Homo sapiens	13-17
35045292-7	2022	Most importantly, pharmacological inhibition of JAK2 reverts vitamin D-induced tolerogenic properties of DCs.	Vitamin D	61-70	Janus kinase 2	Homo sapiens	48-52
35053224-8	2022	Furthermore, given that vitamin D enhanced the shedding of ACE2, some studies reported that vitamin D treatment is associated with prognosis improvement in COVID-19.	Vitamin D	24-33	angiotensin converting enzyme 2	Homo sapiens	59-63
35053224-8	2022	Furthermore, given that vitamin D enhanced the shedding of ACE2, some studies reported that vitamin D treatment is associated with prognosis improvement in COVID-19.	Vitamin D	92-101	angiotensin converting enzyme 2	Homo sapiens	59-63
35096006-9	2021	Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6.	Vitamin D	75-84	protein tyrosine phosphatase receptor type U	Homo sapiens	147-152
2560171-2	1989	Calmodulin inhibitors block vitamin D-induced Ca2+ transport in the gut and phosphorus uptake in renal BBMV"s.	Vitamin D	28-37	calmodulin 1	Rattus norvegicus	0-10
2840181-2	1988	We investigated whether vitamin D itself or a metabolite of vitamin D was responsible for modulating the activity of vitamin D-25-hydroxylase.	Vitamin D	24-33	cytochrome P450, family 2, subfamily r, polypeptide 1	Rattus norvegicus	117-141
2840181-2	1988	We investigated whether vitamin D itself or a metabolite of vitamin D was responsible for modulating the activity of vitamin D-25-hydroxylase.	Vitamin D	60-69	cytochrome P450, family 2, subfamily r, polypeptide 1	Rattus norvegicus	117-141
34590760-11	2021	This study concludes that MAPKs/AP-1 pathway is involved in AMD-induced lung inflammation and that vitamin D and/or losartan could be used as a prophylactic agent to prevent AMD-induced lung toxicity.	Vitamin D	99-108	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-36
34884710-0	2021	The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis.	Vitamin D	15-24	interleukin 33	Homo sapiens	46-51
34884710-8	2021	Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent.	Vitamin D	27-36	interleukin 33	Homo sapiens	54-59
34884710-11	2021	Our data indicated that vitamin D can modulate IL-33 signaling, opening up new perspectives for our understanding of the mechanism of vitamin D action in psoriasis therapy.	Vitamin D	24-33	interleukin 33	Homo sapiens	47-52
34884710-11	2021	Our data indicated that vitamin D can modulate IL-33 signaling, opening up new perspectives for our understanding of the mechanism of vitamin D action in psoriasis therapy.	Vitamin D	134-143	interleukin 33	Homo sapiens	47-52
34784554-9	2021	Vitamin D increased ACE2 expression and Ang-1-7 plasma levels and also decreased Ang II level in plasma.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	20-24
34784554-9	2021	Vitamin D increased ACE2 expression and Ang-1-7 plasma levels and also decreased Ang II level in plasma.	Vitamin D	0-9	angiopoietin 1	Homo sapiens	40-47
34844012-3	2022	Indeed, in these different species, enzymes metabolizing vitamin D (CYP27A1, CYP27B1 and CYP2R1) have been demonstrated in this tissue.	Vitamin D	57-66	cytochrome P450 family 27 subfamily B member 1	Equus caballus	77-84
34619249-6	2021	In non-PCOS controls, plasma ACE2 decreased from vitamin D insufficiency to deficiency (p < 0.05).	Vitamin D	49-58	angiotensin converting enzyme 2	Homo sapiens	29-33
34619249-9	2021	In addition, decreased plasma ACE2 levels were seen in vitamin D deficiency in non-PCOS controls, which may predispose these vitamin D deficient subjects to increased cardiovascular risk and susceptibility to infectious agents such as COVID-19 where this is a risk factor.	Vitamin D	55-64	angiotensin converting enzyme 2	Homo sapiens	30-34
34619249-9	2021	In addition, decreased plasma ACE2 levels were seen in vitamin D deficiency in non-PCOS controls, which may predispose these vitamin D deficient subjects to increased cardiovascular risk and susceptibility to infectious agents such as COVID-19 where this is a risk factor.	Vitamin D	125-134	angiotensin converting enzyme 2	Homo sapiens	30-34
34769269-2	2021	Vitamin D derivatives with high VDR affinity and resistance to CYP24A1-mediated metabolism could be good therapeutic agents.	Vitamin D	0-9	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	63-70
34769269-7	2021	One of our original vitamin D derivatives, which displays high affinity VDR binding and resistance to CYP24A1-dependent metabolism, has shown good therapeutic effects in Vdr (R270L) rats, although further analysis is needed.	Vitamin D	20-29	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	102-109
3754871-2	1986	The present studies were performed to further characterize a mouse yolk sac protein which is similar or identical to the vitamin D-dependent intestinal calcium-binding protein (CaBP).	Vitamin D	121-130	S100 calcium binding protein G	Mus musculus	152-175
34616834-1	2021	This study provides novel insights into mechanisms of traffic-related air pollution-induced allergy by down-regulation via complement regulators (CFI, PROS1 and PLG) and its interaction with vitamin D deficiency via the complement inhibitor PLG https://bit.ly/3x0jYOw.	Vitamin D	191-200	plasminogen	Homo sapiens	161-164
34616834-1	2021	This study provides novel insights into mechanisms of traffic-related air pollution-induced allergy by down-regulation via complement regulators (CFI, PROS1 and PLG) and its interaction with vitamin D deficiency via the complement inhibitor PLG https://bit.ly/3x0jYOw.	Vitamin D	191-200	plasminogen	Homo sapiens	241-244
3754871-2	1986	The present studies were performed to further characterize a mouse yolk sac protein which is similar or identical to the vitamin D-dependent intestinal calcium-binding protein (CaBP).	Vitamin D	121-130	S100 calcium binding protein G	Mus musculus	177-181
34081342-4	2021	We aimed to elucidate the possible association of vitamin D deficiency with the PD-1/PD-L1 axis and inflammatory response in LN patients, as well as, the relationship between PD-1/PD-L1 axis and chemokine C-X-C motif ligand 12 (CXCL12).	Vitamin D	50-59	C-X-C motif chemokine ligand 12	Homo sapiens	205-226
34081342-10	2021	Moreover, CXCL12 was negatively correlated with the PD-1/PD-L1 axis and vitamin D concentration.	Vitamin D	72-81	C-X-C motif chemokine ligand 12	Homo sapiens	10-16
3754871-11	1986	The in vitro response of yolk sac CaBP to calcitriol is the first evidence of a vitamin D effect on the fetal membranes and suggests one function for calcitriol receptors in these tissues.	Vitamin D	80-89	S100 calcium binding protein G	Mus musculus	34-38
6332645-3	1984	Enzymes required for the synthesis of the new metabolite are absent in the vitamin D deplete animal but are induced along with the 25-hydroxyvitamin-D3 24-hydroxylase by vitamin D repletion.	Vitamin D	75-84	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	131-166
34508344-9	2021	In combination with vitamin D, flavonoids possibly activate nuclear factor erythroid-derived-2-related factor 2 that downregulates ACE2 expression in cells.	Vitamin D	20-29	angiotensin converting enzyme 2	Homo sapiens	131-135
6332645-3	1984	Enzymes required for the synthesis of the new metabolite are absent in the vitamin D deplete animal but are induced along with the 25-hydroxyvitamin-D3 24-hydroxylase by vitamin D repletion.	Vitamin D	170-179	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	131-166
34399781-6	2021	The results of linear regression on the relationship between 25-OH-vitamin D serum level and FTO and IRX3 genes expression based on FTO genotypes for rs9930506 indicated that in AA/AG genotype carriers, serum 25-OH-vitamin D level was positively associated with FTO gene expression (B = 0.07, p = 0.02) and inversely associated with IRX3 gene expression (B = - 0.07, p = 0.03).	Vitamin D	215-224	iroquois homeobox 3	Homo sapiens	101-105
6299202-1	1983	The ability of four vitamin D analogs to inhibit the liver microsomal vitamin D-25-hydroxylase was determined.	Vitamin D	20-29	cytochrome P450, family 2, subfamily r, polypeptide 1	Rattus norvegicus	70-94
34458299-4	2021	Research Question: To understand the relationship between vitamin D, lung AAT levels and T lymphocytes further we investigated whether TGF-beta is required as a co-factor for 1,25(OH)2D3-induced upregulation of AAT by vitamin D in CD8+ T cells in vitro and correlated circulating vitamin D levels with lung AAT levels in vivo.	Vitamin D	218-227	transforming growth factor alpha	Homo sapiens	135-143
34362362-1	2021	BACKGROUND: This study aimed to investigate, if different physiological concentrations of vitamin D (25(OH)D3) and single nucleotide polymorphisms in vitamin D receptor (VDR) gene have an impact on gene expression in human periodontal ligament (hPDL) fibroblasts induced by simulated orthodontic compressive strain.	Vitamin D	90-99	programmed cell death 1	Homo sapiens	245-249
34817518-0	2021	An evaluation of the relationship between vitamin D level and CTRP-9, tumor necrosis factor-alpha, thiol-disulfide hemostasis in women.	Vitamin D	42-51	C1q and TNF related 9	Homo sapiens	62-68
34817518-1	2021	OBJECTIVE: Many chronic diseases such as malignancy, cardiovascular diseases, endothelial dysfunction, and autoimmune diseases, which have been shown to be related to vitamin D in various studies; have similar relations with CTRP-9, TNFalpha, and thiol-disulfide hemostasis.	Vitamin D	167-176	C1q and TNF related 9	Homo sapiens	225-231
34733753-6	2021	Results: PBM at 1 and 2 J/cm2 combined with vitamin D significantly promoted HDPSCs proliferation through MTT assay and odontogenic differentiation through gene expression of VEGF, BMP-2, and DSPP levels (P < 0.0001).	Vitamin D	44-53	bone morphogenetic protein 2	Homo sapiens	181-186
34733753-6	2021	Results: PBM at 1 and 2 J/cm2 combined with vitamin D significantly promoted HDPSCs proliferation through MTT assay and odontogenic differentiation through gene expression of VEGF, BMP-2, and DSPP levels (P < 0.0001).	Vitamin D	44-53	dentin sialophosphoprotein	Homo sapiens	192-196
34208589-7	2021	Moreover, vitamin D strengthens the DNA repair process, and regulates apoptosis and autophagy of cancer cells as well as signaling pathways involved in tumorigenesis i.e., tumor growth factor beta (TGFbeta), insulin-like growth factor (IGF) and Wnt-beta-Cathenin.	Vitamin D	10-19	transforming growth factor alpha	Homo sapiens	198-205
35619053-0	2022	Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice.	Vitamin D	11-20	retinoid X receptor alpha	Mus musculus	98-102
35619053-2	2022	The MAVIDOS study has demonstrated that vitamin D supplementation leads to reduced RXRA DNA methylation.	Vitamin D	40-49	retinoid X receptor alpha	Mus musculus	83-87
35500429-8	2022	The levels of IL-1beta, TNF-alpha, and NF-kB p65 in knee OA patients with vitamin D insufficiency were significantly higher compared with the knee OA patients with sufficient vitamin D (P < 0.05).	Vitamin D	74-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	45-48
35500429-9	2022	Based on the linear regression analysis, serum vitamin D levels were inversely correlated with IL-1beta, TNF-alpha, hs-CRP, and NF-kB p65 levels (P < 0.0001).	Vitamin D	47-56	RELA proto-oncogene, NF-kB subunit	Homo sapiens	134-137
35242513-0	2022	The effect of vitamin D deficiency on the RANKL/OPG ratio in rats.	Vitamin D	14-23	TNF superfamily member 11	Rattus norvegicus	42-47
35242513-1	2022	The aim of this study was to determine the effect of vitamin D deficiency on the RANKL/OPG ((Receptor Activator of Nuclear Factor Kappa B Ligand/Osteoprotegerin) ratio in the serum blood levels.	Vitamin D	53-62	TNF superfamily member 11	Rattus norvegicus	81-86
35242513-1	2022	The aim of this study was to determine the effect of vitamin D deficiency on the RANKL/OPG ((Receptor Activator of Nuclear Factor Kappa B Ligand/Osteoprotegerin) ratio in the serum blood levels.	Vitamin D	53-62	TNF superfamily member 11	Rattus norvegicus	93-144
35242513-6	2022	The serum RANKL levels and RANKL/OPG ratio in rats, were negatively affected by the deficiency of vitamin D.	Vitamin D	98-107	TNF superfamily member 11	Rattus norvegicus	10-15
35242513-6	2022	The serum RANKL levels and RANKL/OPG ratio in rats, were negatively affected by the deficiency of vitamin D.	Vitamin D	98-107	TNF superfamily member 11	Rattus norvegicus	27-32
34779388-7	2022	However, the concentration of free vitamin D was independently associated with SBP (95% CI -2.691 ~ -0.210; p = 0.022) (Table 3), but not with DBP (95% CI -0.934 ~ 0.285; p = 0.293).	Vitamin D	35-44	selenium binding protein 1	Homo sapiens	79-82
2683727-2	1989	These are 1) complexity of the domain of bone health, 2) difficulty in detecting bone fragility in vivo, 3) difficulty in detecting useful changes in bone mass, 4) remodeling transients, and 5) lack of standards for assessing adequacy of vitamin D nutriture in elderly subjects.	Vitamin D	238-247	VPS52 subunit of GARP complex	Homo sapiens	6-11
2777759-0	1989	Transcriptional regulation of the parathyroid hormone-related peptide gene by glucocorticoids and vitamin D in a human C-cell line.	Vitamin D	98-107	parathyroid hormone like hormone	Homo sapiens	34-69
2777759-5	1989	We found that both the synthetic glucocorticoid, dexamethasone, and the active vitamin D metabolite, 1,25-dihydroxyvitamin D3, decreased steady-state PTHRP mRNA levels in TT cells in a time- and dose-dependent fashion.	Vitamin D	79-88	parathyroid hormone like hormone	Homo sapiens	150-155
2777759-9	1989	These findings indicate that the PTHRP gene is under the transcriptional control of glucocorticoids and vitamin D in a cell line with prototypical neuroendocrine features.	Vitamin D	104-113	parathyroid hormone like hormone	Homo sapiens	33-38
2460662-9	1988	This work demonstrates, for the first time, that epitopes of vitamin D-inducible 28kDa-CaBp and human erythrocyte Ca++-Mg++ ATPase pump are present in the same cells of the human kidney.	Vitamin D	61-70	dynein axonemal heavy chain 8	Homo sapiens	124-130
3166829-4	1988	Vitamin D deficiency resulted in elevated serum PTH values but did not produce significant changes in serum Ca levels, femur length, femur ash weight to body weight ratio, or tibial breaking strength.	Vitamin D	0-9	parathyroid hormone	Oryctolagus cuniculus	48-51
2891728-0	1988	Regulation of calcitonin gene transcription by vitamin D metabolites in vivo in the rat.	Vitamin D	47-56	calcitonin-related polypeptide alpha	Rattus norvegicus	14-24
3251041-4	1988	In spite of this hypocalcemia, a significant rise in plasma CT levels was observed within 5 min in D+ animals and within 30 min in D- animals after injection of the vitamin D metabolite.	Vitamin D	165-174	calcitonin-related polypeptide alpha	Rattus norvegicus	60-62
2850461-6	1988	In vitamin D-replete rats, 0.05 U/h CT as well as 0.5 U/h CT caused a stimulation of tubular Ca reabsorption.	Vitamin D	3-12	calcitonin-related polypeptide alpha	Rattus norvegicus	36-38
2850461-6	1988	In vitamin D-replete rats, 0.05 U/h CT as well as 0.5 U/h CT caused a stimulation of tubular Ca reabsorption.	Vitamin D	3-12	calcitonin-related polypeptide alpha	Rattus norvegicus	58-60
2850461-10	1988	These results demonstrate that CT stimulates renal tubular Ca reabsorption, and that vitamin D status modulates the responsiveness of renal tubules to CT.	Vitamin D	85-94	calcitonin-related polypeptide alpha	Rattus norvegicus	151-153
3689395-3	1987	alpha-Tubulin mRNA was elevated in vitamin D-deficient (-D) chicks and those treated with 1,25(OH)2D3 for 1-10 h prior to sacrifice, but declined precipitously 15-20 h after hormone, and in normal birds.	Vitamin D	35-44	tubulin alpha-5 chain	Gallus gallus	0-13
3478171-5	1987	These results suggest that the hormonal form of vitamin D regulates the biosynthesis of osteopontin, possibly at the level of transcription.	Vitamin D	48-57	secreted phosphoprotein 1	Rattus norvegicus	88-99
3838942-1	1985	Vitamin D metabolites are able to change plasma calcitonin (CT) levels, but nothing is known about a possible effect at the CT gene level.	Vitamin D	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	60-62
3838942-1	1985	Vitamin D metabolites are able to change plasma calcitonin (CT) levels, but nothing is known about a possible effect at the CT gene level.	Vitamin D	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	48-58
6479099-0	1984	Low levels of intestinal vitamin D-dependent calcium-binding protein in juvenile X-linked hypophosphatemic mice.	Vitamin D	25-34	S100 calcium binding protein G	Mus musculus	45-68
6086274-6	1984	The vitamin D-deficient, low calcium diet led to a significant and comparable increase in serum PTH and urinary excretion of cAMP in +/Y and Hyp/Y, suggesting that the mutant strain had an appropriate PTH response to the diet-induced fall in serum calcium.	Vitamin D	4-13	parathyroid hormone	Mus musculus	96-99
6086274-6	1984	The vitamin D-deficient, low calcium diet led to a significant and comparable increase in serum PTH and urinary excretion of cAMP in +/Y and Hyp/Y, suggesting that the mutant strain had an appropriate PTH response to the diet-induced fall in serum calcium.	Vitamin D	4-13	parathyroid hormone	Mus musculus	201-204
6610503-2	1984	Vitamin D metabolites were rapidly extracted from plasma by using Sep-Pak C18 cartridges and separated into fractions on Sep-Pak SIL cartridges.	Vitamin D	0-9	STIL centriolar assembly protein	Homo sapiens	129-132
6897034-3	1982	In vitamin D-deficient chicks, the activities of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase were markedly higher in the crypt cells than in the villus cells.	Vitamin D	3-12	ornithine decarboxylase	Gallus gallus	49-72
6897034-3	1982	In vitamin D-deficient chicks, the activities of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase were markedly higher in the crypt cells than in the villus cells.	Vitamin D	3-12	ornithine decarboxylase	Gallus gallus	74-77
7460832-0	1981	The mechanism of the action of growth hormone on vitamin D metabolism in the rat.	Vitamin D	49-58	gonadotropin releasing hormone receptor	Rattus norvegicus	31-45
437784-0	1979	Neuraminidase treatment reveals sialic acid differences in certain genetic variants of the Gc system (vitamin-D-binding protein).	Vitamin D	102-111	neuraminidase 1	Homo sapiens	0-13
867174-0	1977	Serum levels of 25-hydroxycholecalciferol as a diagnostic aid in vitamin D deficiency states.	Vitamin D	65-74	activation induced cytidine deaminase	Homo sapiens	58-61
33713690-5	2021	This highly polymorphic protein is not only the major transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites, but also participates in the transport of the 25(OH)D into the cell via a megalin/cubilin complex.	Vitamin D	133-142	LDL receptor related protein 2	Homo sapiens	230-237
33895875-3	2021	Fibroblast growth factor 23 (FGF23) is a paracrine and endocrine mediator produced by bone cells and regulates phosphate and vitamin D metabolism in the kidney.	Vitamin D	125-134	fibroblast growth factor 23	Rattus norvegicus	0-27
33895875-3	2021	Fibroblast growth factor 23 (FGF23) is a paracrine and endocrine mediator produced by bone cells and regulates phosphate and vitamin D metabolism in the kidney.	Vitamin D	125-134	fibroblast growth factor 23	Rattus norvegicus	29-34
33990955-6	2021	Hence, vitamin D deficiency can exacerbate COVID-19, via its effects on ACE2.	Vitamin D	7-16	angiotensin converting enzyme 2	Homo sapiens	72-76
33760197-0	2021	MicroRNA-378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells.	Vitamin D	51-60	rosbin, round spermatid basic protein 1	Mus musculus	42-47
4083532-2	1985	This protein is similar or identical to vitamin D-dependent intestinal CaBP and these proteins have been implicated in the molecular mechanisms of intestinal calcium absorption and transplacental calcium transport.	Vitamin D	40-49	S100 calcium binding protein G	Mus musculus	71-75
6688913-14	1983	Compared to growth hormone, which is the major bone growth stimulating agent, the influences on bone formation of the vitamin D metabolites were minor and predominantly negative.	Vitamin D	118-127	gonadotropin releasing hormone receptor	Rattus norvegicus	12-26
3838303-1	1985	We have reported that the duodenal ornithine decarboxylase activity and the tissue content of putrescine increase markedly after a single intravenous injection of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3) into vitamin D-deficient chicks (Shinki, T., Takahashi, N., Miyaura, C., Samejima, K., Nishii, Y., and Suda, T. (1981) Biochem.	Vitamin D	183-192	ornithine decarboxylase 1	Homo sapiens	35-58
33865853-9	2021	Taken together, our data indicate that Cyp24a1 KO rats are valuable for metabolic studies of vitamin D and its analogs.	Vitamin D	93-102	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	39-46
7061707-13	1982	Therefore, due to the different affinities of DBP for the various metabolites of vitamin D, only 1,25(OH)(2)D(3) is extracted in vitro in significant amounts by bone of normal adult dogs, in the presence of DBP.	Vitamin D	81-90	D-box binding PAR bZIP transcription factor	Canis lupus familiaris	46-49
33927639-8	2021	In cardiac tissue, vitamin D treatment induces an elevation significantly of the mRNA expression of Pgc1-alpha, Mfn-1, and Drp-1 genes (p = 0.001).	Vitamin D	19-28	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	100-110
33927639-8	2021	In cardiac tissue, vitamin D treatment induces an elevation significantly of the mRNA expression of Pgc1-alpha, Mfn-1, and Drp-1 genes (p = 0.001).	Vitamin D	19-28	mitofusin 1	Mus musculus	112-117
33716989-10	2021	Vitamin D deficiency was associated with decreased CD80 and IFN-gamma in PCOS and IL-12 in both groups (p<0.05).	Vitamin D	0-9	CD80 molecule	Homo sapiens	51-55
6326677-6	1984	Thus, although the vitamin D-dependent CaBPs and calmodulin are similar in that they are small, acidic, calcium-binding proteins, these two classes of proteins are biochemically and immunochemically distinct.	Vitamin D	19-28	calmodulin 1	Rattus norvegicus	49-59
6324177-2	1983	Incubation of these cells with the vitamin D metabolite at 10 nM for 5 days produced marked stimulation in adherence and ingestion of Staphylococcus aureus (645% of control) and of C3b receptor (CR1) expression (292% of control) and a slight increase in hexose monophosphate shunt activity without changing cell growth rates or Fc fragment receptor expression.	Vitamin D	35-44	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	195-198
6175546-0	1982	Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation.	Vitamin D	0-9	tyrosinase	Rattus norvegicus	35-45
6678614-1	1983	The amount of reducing equivalents from NADPH generated by glucose 6-phosphate dehydrogenase activity (G6PD) used in mixed function oxidation (pathway I) or in reductive biosynthesis (pathway II) has been determined by cytochemical methods and microdensitometry in cells from the pars recta (PR) and distal convoluted tubule (DCT) of the kidney and from centrilobular (CL) and periportal (PP) hepatocytes from rats fed a normal or a vitamin D-deficient diet.	Vitamin D	433-442	glucose-6-phosphate dehydrogenase	Rattus norvegicus	59-92
6678614-1	1983	The amount of reducing equivalents from NADPH generated by glucose 6-phosphate dehydrogenase activity (G6PD) used in mixed function oxidation (pathway I) or in reductive biosynthesis (pathway II) has been determined by cytochemical methods and microdensitometry in cells from the pars recta (PR) and distal convoluted tubule (DCT) of the kidney and from centrilobular (CL) and periportal (PP) hepatocytes from rats fed a normal or a vitamin D-deficient diet.	Vitamin D	433-442	glucose-6-phosphate dehydrogenase	Rattus norvegicus	103-107
33977215-8	2021	The vitamin D receptor (VDR) is important for vitamin D metabolism; however, there is much more to understand about VDR in chickens.	Vitamin D	4-13	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	24-27
33671779-12	2021	The density of AT1R staining was the highest in the male Vitamin D deficient group.	Vitamin D	57-66	angiotensin II receptor, type 1a	Rattus norvegicus	15-19
6175546-10	1982	The relationship observed between the vitamin D status of animals and tyrosinase activity of skin could provide an effective feed-back control for protection against UV and vitamin D intoxication.	Vitamin D	38-47	tyrosinase	Rattus norvegicus	70-80
6175546-4	1982	In contrast, the induction of tyrosinase activity provoked by UV radiation was greater in vitamin-D-fed than in vitamin-D-deficient rats.	Vitamin D	90-99	tyrosinase	Rattus norvegicus	30-40
6175546-10	1982	The relationship observed between the vitamin D status of animals and tyrosinase activity of skin could provide an effective feed-back control for protection against UV and vitamin D intoxication.	Vitamin D	173-182	tyrosinase	Rattus norvegicus	70-80
6175546-4	1982	In contrast, the induction of tyrosinase activity provoked by UV radiation was greater in vitamin-D-fed than in vitamin-D-deficient rats.	Vitamin D	112-121	tyrosinase	Rattus norvegicus	30-40
6175546-7	1982	The pretreatment of rats with phosphodiesterase inhibitor potentiated the effect of vitamin D on skin tyrosinase activity.	Vitamin D	84-93	tyrosinase	Rattus norvegicus	102-112
6894454-2	1981	The metabolic disposition of the plasma binding protein (DBP) for vitamin D and its metabolites was studied in adult rabbits.	Vitamin D	66-75	vitamin D-binding protein	Oryctolagus cuniculus	57-60
6895593-2	1981	The duodenal ornithine decarboxylase activity decreased in animals fed a vitamin D-deficient diet and its retarded activity was increased dose-dependently by a single injection of cholecalciferol.	Vitamin D	73-82	ornithine decarboxylase	Gallus gallus	13-36
33241290-8	2021	In the 4C study cohort, treatment over a mean period of 9 months with active vitamin D was associated with increased FGF23 and phosphate and decreased sKlotho and eGFR compared with vitamin D naive controls, whereas LV mass index did not differ between groups.	Vitamin D	77-86	fibroblast growth factor 23	Rattus norvegicus	117-122
32679589-4	2021	Vitamin D can induce the expression of angiotensin-converting enzyme 2 and regulate the immune system through different mechanisms.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	39-70
6894454-15	1981	The molar excess of DBP to 25(OH)D3 in plasma, and the relatively rapid turnover of DBP indicate that a high capacity, high affinity, and dynamic transport mechanism for vitamin D sterols exists in rabbit plasma.	Vitamin D	170-179	vitamin D-binding protein	Oryctolagus cuniculus	20-23
6247135-1	1980	The influence of the vitamin D status on the concentration of the serum vitamin D-binding protein was studied.	Vitamin D	21-30	GC, vitamin D binding protein	Rattus norvegicus	72-97
6894454-15	1981	The molar excess of DBP to 25(OH)D3 in plasma, and the relatively rapid turnover of DBP indicate that a high capacity, high affinity, and dynamic transport mechanism for vitamin D sterols exists in rabbit plasma.	Vitamin D	170-179	vitamin D-binding protein	Oryctolagus cuniculus	84-87
4276472-10	1974	The altered response of bone cells in uremic rats given vitamin D was postulated to be due to the elevated serum phosphorus and greater release of calcitonin from thyroid C cells.	Vitamin D	56-65	calcitonin-related polypeptide alpha	Rattus norvegicus	147-157
33488605-9	2020	Emerging evidence suggests a functional link between vitamin D and the IL-33/ST2 axis, which acts through hormonal influences and immune-mediated effects, as well as cellular and metabolic functions.	Vitamin D	53-62	interleukin 33	Homo sapiens	71-76
33869246-10	2021	In addition, the restoration of vitamin D levels reestablished the amount of MCP1 and the renal expressions of CD68+ and CD3+ cells in the VDD+IRI+R rats.	Vitamin D	32-41	Cd68 molecule	Rattus norvegicus	111-115
33413534-0	2021	Are vitamin D and vitamin D receptor levels different in children with developmental dysplasia of the hip?	Vitamin D	4-13	hedgehog interacting protein	Homo sapiens	102-105
33596463-0	2021	Altered expression of the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 under the context of prostate aging and pathologies.	Vitamin D	26-35	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	69-76
33578174-0	2021	Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia.	Vitamin D	17-26	MYD88 innate immune signal transduction adaptor	Homo sapiens	97-102
33201249-9	2021	A total of 155 (18%) developed delirium, and the risk was higher in vitamin D-deficient patients (odds ratio (OR) 1.48, 95% confidence interval (CI) 1.04 to 2.12; p = 0.03).	Vitamin D	68-77	olfactory receptor family 4 subfamily N member 2	Homo sapiens	98-118
33409846-7	2021	SARS-CoV-2, by using the well-known angiotensin-converting enzyme 2 by the protein spike, as the host receptor to enter into alveolar, myocardial, and renal epithelial cells, can be disrupted by vitamin D.	Vitamin D	195-204	angiotensin converting enzyme 2	Homo sapiens	36-67
33785437-1	2021	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is a potent regulator of immune function, promoting anti-inflammatory, tolerogenic T cell responses by modulating antigen presentation by dendritic cells (DC).	Vitamin D	19-28	decorin	Mus musculus	217-219
33409846-7	2021	SARS-CoV-2, by using the well-known angiotensin-converting enzyme 2 by the protein spike, as the host receptor to enter into alveolar, myocardial, and renal epithelial cells, can be disrupted by vitamin D.	Vitamin D	195-204	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	83-88
32909857-3	2021	The present study aims to examine whether COX-1 and COX-2 were implicated in endothelial dysfunction in hypertension and calcitriol, an active form of vitamin D preserved endothelial function through regulating COX expression.	Vitamin D	151-160	cytochrome c oxidase subunit 8A	Homo sapiens	42-45
33856702-1	2021	Genetic causes of vitamin D-related hypercalcemia are known to involve mutation of 25-hydroxyvitamin D-24-hydroxylase CYP24A1 or the sodium phosphate co-transporter SLC34A1; which result in excessive 1,25-(OH)2 D hormonal action.	Vitamin D	18-27	solute carrier family 34 member 1	Homo sapiens	165-172
33856702-3	2021	In this case-control study, we used precision vitamin D metabolite profiling based on LC-MS/MS of an expanded range of vitamin D metabolites - to screen German and French cohorts of hypercalcemia patients, to identify patients with altered vitamin D metabolism where involvement of CYP24A1 or SLC34A1 mutation had been ruled out, and possessed normal 25-OH-D3 :24,25-(OH)2 D3 ratios.	Vitamin D	46-55	solute carrier family 34 member 1	Homo sapiens	293-300
33849913-2	2021	Vitamin D is a potential prevention therapy for both Er+ and Er- disease and is safe with few side effects.	Vitamin D	0-9	epiregulin	Homo sapiens	53-55
33849913-2	2021	Vitamin D is a potential prevention therapy for both Er+ and Er- disease and is safe with few side effects.	Vitamin D	0-9	epiregulin	Homo sapiens	61-63
33757126-6	2022	Overexpression of SMOC1 attenuated warfarin-induced AVIC calcification but promoted high calcium/phosphate or vitamin D-induced AVIC and aortic valve calcification by regulating BMP2 signalling both in vitro and in vivo.	Vitamin D	110-119	SPARC related modular calcium binding 1	Homo sapiens	18-23
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	solute carrier family 2 member 4	Homo sapiens	56-61
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	solute carrier family 2 member 4	Homo sapiens	202-207
33258437-5	2021	We found several studies which indicated that supplemental vitamin C, vitamin D, vitamin E, and zinc may be useful adjuncts in DF treatment.	Vitamin D	70-79	complement factor D	Homo sapiens	127-129
33791129-11	2021	Conclusion: Vitamin D deficiency is highly prevalent among patients on hemodialysis with or without DM2.	Vitamin D	12-21	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	100-103
32990980-2	2021	Vitamin D (VitD) can upregulate ACE2 and has an antagonistic effect on Renin, which exerts a vasodilatation and anti-inflammatory effect against coronavirus disease (COVID-19).	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	32-36
33712053-4	2021	RESULTS: Our results showed that vitamin D receptor (VDR), as a mediator of most actions of 1,25-dihydroxyvitamin D3, glucose trasporter-4 (GLUT4),and fatty acid binding protein-4 (FABP4) was expressed in vitamin D-treated hASCs.	Vitamin D	33-42	solute carrier family 2 member 4	Homo sapiens	118-138
33712053-4	2021	RESULTS: Our results showed that vitamin D receptor (VDR), as a mediator of most actions of 1,25-dihydroxyvitamin D3, glucose trasporter-4 (GLUT4),and fatty acid binding protein-4 (FABP4) was expressed in vitamin D-treated hASCs.	Vitamin D	33-42	solute carrier family 2 member 4	Homo sapiens	140-145
33693593-0	2021	Vitamin D regulates CXCL12/CXCR4 and epithelial-to-mesenchymal transition in a model of breast cancer metastasis to lung.	Vitamin D	0-9	C-X-C motif chemokine ligand 12	Homo sapiens	20-26
33664952-4	2021	Vitamin D played a role in inhibiting HMGB1 secretion in the animal study.	Vitamin D	0-9	high mobility group box 1	Homo sapiens	38-43
33664952-11	2021	Conclusions: Strong negative correlation between VDR and HMGB1 in different immunodeficiency statuses suggesting an important role of vitamin D in inflammation control in HIV infection.	Vitamin D	134-143	high mobility group box 1	Homo sapiens	57-62
32416695-0	2021	High prevalence of vitamin D deficiency and correlation with cystatin-C and other cardiovascular and renal risk biomarkers in patients with type 2 diabetes mellitus complicated with hypertension.	Vitamin D	19-28	cystatin C	Homo sapiens	61-71
33693593-3	2021	We investigate here the action mechanism for vitamin D in lung metastasis in the same non-immunodeficient model and demonstrate it involves the control of epithelial to mesenchymal transition as well as interactions between chemokine CXCL12 and its receptor CXCR4.	Vitamin D	45-54	chemokine (C-X-C motif) ligand 12	Mus musculus	234-240
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	30-34
33693593-6	2021	In vivo, dietary vitamin D deficiency maintains high levels of Zeb1 and p-STAT3 in cells from primary mammary tumors, and increases CXCL12 expression in lung stroma by 64%.	Vitamin D	17-26	C-X-C motif chemokine ligand 12	Homo sapiens	132-138
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	178-182
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	89-98	angiotensin converting enzyme 2	Homo sapiens	30-34
33693593-7	2021	In lung metastases, vitamin D deficiency increases CXCL12/CXCR4 co-localization by a factor of 2.5.	Vitamin D	20-29	C-X-C motif chemokine ligand 12	Homo sapiens	51-57
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	89-98	angiotensin converting enzyme 2	Homo sapiens	178-182
33159645-8	2021	Other vitamin D-related genes (including DHCR7/NADSYN1, CYP2R1, CYP27A1, CYP3A4, CYP27B1, CYP24A1, Megalin-DAB2-Cubilin, FGF-23, and Klotho) have been less investigated and achieved more conflicting evidence.	Vitamin D	6-15	LDL receptor related protein 2	Homo sapiens	99-106
33159645-8	2021	Other vitamin D-related genes (including DHCR7/NADSYN1, CYP2R1, CYP27A1, CYP3A4, CYP27B1, CYP24A1, Megalin-DAB2-Cubilin, FGF-23, and Klotho) have been less investigated and achieved more conflicting evidence.	Vitamin D	6-15	DAB adaptor protein 2	Homo sapiens	107-111
33030742-11	2021	In term placentas, PAPP-A expression was lower among participants with first trimester vitamin D insufficiency (p=0.009; n=30) but no correlation was found between plasma 25-hydroxyvitamin D and mRNA expression of CYP24A1 (p=0.67) and CYP27B1 (p=0.34).	Vitamin D	87-96	pappalysin 1	Homo sapiens	19-25
33408861-6	2021	Overexpression of CEA and PDGF was noted in the carcinogenic group, while expression of CEA and PDGF in the prophylactic, vitamin D and indomethacin and 5-FU groups were markedly reduced.	Vitamin D	122-131	CEA cell adhesion molecule 20	Rattus norvegicus	88-91
32613681-0	2021	Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.	Vitamin D	13-22	angiotensin converting enzyme 2	Homo sapiens	121-125
33247302-11	2021	CONCLUSIONS: In the elderly, low vitamin D status was associated with low-frequency and speech-frequency HL.	Vitamin D	33-42	lipase C, hepatic type	Homo sapiens	105-107
33205696-10	2021	Moreover, in patients with vitamin D deficiency, the expression of TJ proteins (Occludin, claudin-1, ZO-1 and JAM-1) in the intestinal mucosa was reduced, and Treg cells in the peripheral blood were decreased, while Th17 cells were increased compared to those with vitamin D sufficiency and controls.	Vitamin D	27-36	occludin	Homo sapiens	80-88
33341448-5	2021	RESULTS: Across all tumour stages, vitamin D-deficient patients had the highest median levels of IL-6 (8.3 pg/mL, range 0.7-91), YKL-40 (177 ng/ml, range 25-5279) and CRP (15.5 mg/L, range 0.8-384).	Vitamin D	35-44	chitinase 3 like 1	Homo sapiens	129-135
33247302-12	2021	Low vitamin D status may be a potential risk factor for age-related HL.	Vitamin D	4-13	lipase C, hepatic type	Homo sapiens	68-70
32423279-11	2021	Vitamin D increased stromal cyclooxygenase-2 expression that may have an effect on increasing mucosal damage.	Vitamin D	0-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	28-44
32773651-4	2021	Effects of vitamin D on SBP or DBP were analyzed using mixed-effects models.	Vitamin D	11-20	selenium binding protein 1	Homo sapiens	24-27
32613681-9	2021	Experimentally, vitamin D increases the ratio of angiotensin-converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.	Vitamin D	16-25	angiotensin converting enzyme 2	Homo sapiens	49-80
32613681-9	2021	Experimentally, vitamin D increases the ratio of angiotensin-converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.	Vitamin D	16-25	angiotensin converting enzyme 2	Homo sapiens	82-86
33554929-10	2021	Additional studies on seasonal variation in BPPV are required in terms of not only vitamin D levels but also other associated factors.	Vitamin D	83-92	benign paroxysmal positional vertigo	Homo sapiens	44-48
33259938-9	2021	These data suggested that vitamin D/VDR could alleviate cisplatin-induced acute renal injury partly by inhibiting NF-kappaB-mediated NLRP3/Caspase-1/GSDMD pyroptosis.	Vitamin D	26-35	caspase 1	Mus musculus	139-148
33309619-0	2021	Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC).	Vitamin D	0-9	histidine rich calcium binding protein	Homo sapiens	90-93
32827684-1	2020	BACKGROUND: The role of FoxP3, a master regulator of T regulatory cells,in allergicdiseases such as asthma is of immense importance yet the effect of its gene variants on the disease predisposition is not fully understood.We studied the association of FoxP3 polymorphisms (-2383C/T and -3279 C/A) in allergic asthma patients and their correlation with serum IL-4, IL-13, Total IgE, and Vitamin D levels.	Vitamin D	386-395	forkhead box P3	Homo sapiens	24-29
33309619-6	2021	RESULTS: Vitamin D significantly suppressed the expression of HRC in liver fibrosis model both in vivo and in vitro (P<0.01).	Vitamin D	9-18	histidine rich calcium binding protein	Homo sapiens	62-65
33365026-1	2020	Context: Autoimmune polyglandular syndrome (APS-2: autoimmune Addison"s disease or type 1 diabetes) is conferred by predisposing HLA molecules, vitamin D deficiency, and heritable susceptibility.	Vitamin D	144-153	nudix hydrolase 10	Homo sapiens	44-49
33309619-8	2021	However, Vitamin D can significantly reverse the levels of TGF-beta1, Smad3 and p-smad3 caused by HRC in vitro.	Vitamin D	9-18	SMAD family member 3	Homo sapiens	70-75
33365026-8	2020	Expression of IL-23A and vitamin D pathway genes VDR and CYP27B1 varied by HLA genotype and was lower in healthy individuals with high-risk HLA (p = 0.0025; p = 0.04), while healthy controls with low-risk HLA showed a stronger IL-10 and CD14 expression (p = 0.01; p = 0.03).	Vitamin D	25-34	CD14 molecule	Homo sapiens	237-241
33309619-8	2021	However, Vitamin D can significantly reverse the levels of TGF-beta1, Smad3 and p-smad3 caused by HRC in vitro.	Vitamin D	9-18	SMAD family member 3	Homo sapiens	82-87
33309619-8	2021	However, Vitamin D can significantly reverse the levels of TGF-beta1, Smad3 and p-smad3 caused by HRC in vitro.	Vitamin D	9-18	histidine rich calcium binding protein	Homo sapiens	98-101
33309619-9	2021	Furthermore, the overexpression of HRC in cell lines can attenuate the function of Vitamin D, suggesting that VD played a role by regulating HRC.	Vitamin D	83-92	histidine rich calcium binding protein	Homo sapiens	35-38
33309619-11	2021	CONCLUSIONS: Vitamin D can delay hepatic fibrosis by reducing activation of hepatic stellate cells and TGF-beta/Smad signaling through negative regulation of HRC.	Vitamin D	13-22	transforming growth factor alpha	Homo sapiens	103-111
33288743-5	2020	Moreover, we show that the vitamin D analogue ZK168281 enhances the interaction between VDR and WBP4 in the cytosol, and normalizes the expression of VDR target genes and serum calcium levels in 1alpha,25(OH)2D3-intoxicated mice.	Vitamin D	27-36	WW domain binding protein 4	Mus musculus	96-100
33309619-11	2021	CONCLUSIONS: Vitamin D can delay hepatic fibrosis by reducing activation of hepatic stellate cells and TGF-beta/Smad signaling through negative regulation of HRC.	Vitamin D	13-22	histidine rich calcium binding protein	Homo sapiens	158-161
33452895-1	2021	We investigated the effect of vitamin D supplementation on the expression of muscle vitamin D receptor (VDR) and cross-sectional area (CSA) in patients with a distal radius fracture (DRF).	Vitamin D	30-39	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	135-138
31365935-1	2020	OBJECTIVE:  To examine the association of vitamin D insufficiency and risk of pregnancy-induced hypertension (PIH) among human immunodeficiency virus (HIV)-infected pregnant women.	Vitamin D	42-51	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	110-113
33452895-11	2021	Significant increases in VDR expression and CSA were observed in vitamin D-deficient patients [25(OH)D] < 20 ng/mL, but not in vitamin D-non-deficient patients.	Vitamin D	65-74	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	44-47
31365935-2	2020	STUDY DESIGN:  This is a retrospective cohort study evaluating the impact of low maternal vitamin D levels on PIH and perinatal outcomes among HIV-infected pregnant women receiving care at an urban HIV center from 1991 to 2014.	Vitamin D	90-99	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	110-113
33452895-13	2021	CONCLUSION: Vitamin D supplementation may increase muscle VDR expression and CSA in patients with a DRF, especially in vitamin D-deficient patients.	Vitamin D	12-21	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	77-80
31365935-10	2020	CONCLUSION:  Lower bioactive vitamin D levels are related to PIH in HIV-infected women.	Vitamin D	29-38	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	61-64
33452895-14	2021	The increase in CSA without an increase in VDR expression in some patients indicates that the effect of vitamin D supplementation on muscle mass could be mediated by indirect effect of serum vitamin D restoration and by VDR.	Vitamin D	104-113	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	16-19
33452895-14	2021	The increase in CSA without an increase in VDR expression in some patients indicates that the effect of vitamin D supplementation on muscle mass could be mediated by indirect effect of serum vitamin D restoration and by VDR.	Vitamin D	191-200	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	16-19
33305808-3	2021	Here we describe that frataxin-deficient dorsal root ganglia neurons display low levels of ferredoxin 1, a mitochondrial Fe/S cluster-containing protein that interacts with frataxin and, interestingly, is essential for the synthesis of calcitriol, the active form of vitamin D.	Vitamin D	267-276	frataxin	Homo sapiens	22-30
32574107-5	2020	The redness at the inoculation site of bacillus Calmette-Guerin, a specific feature of Kawasaki disease, is reproduced by activation of the STING pathway, which is inhibited upstream by aspirin, intravenous immunoglobulins, and Vitamin-D.	Vitamin D	228-237	stimulator of interferon response cGAMP interactor 1	Homo sapiens	140-145
33519486-11	2020	Conversely, the estimated intake of vitamin D was negatively correlated with the expression of the highest number of circulating miRNAs, particularly miR-1277-5p (rho = -0.393) and miR-144-3p (rho = -0.393).	Vitamin D	36-45	microRNA 1277	Homo sapiens	150-158
33463692-2	2021	We conducted a two-sample Mendelian randomization (MR) study to investigate the causal relationship between genetically determined serum vitamin D levels and hip/knee OA.	Vitamin D	137-146	hedgehog interacting protein	Homo sapiens	96-99
33364287-7	2021	The role of hypovitaminosis D in the pathogenesis of uterine leiomyomata is discussed, including epidemiology data demonstrating a link between ethnicity and risk and the proven mechanisms by which vitamin D controls oestrogen and progesterone receptor expression and influences other signalling pathways involved in the pathogenesis of leiomyomas.	Vitamin D	198-207	progesterone receptor	Homo sapiens	231-252
33224249-2	2020	The objective of the current study was to determine the effects of vitamin D supplementation during a weight-loss intervention on the levels of omentin-1, spexin, lipid profiles, and inflammatory factors in obese and overweight participants.	Vitamin D	67-76	spexin hormone	Homo sapiens	155-161
33304315-0	2020	Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta).	Vitamin D	10-19	class II, major histocompatibility complex, transactivator	Rattus norvegicus	143-148
32675738-6	2020	Acknowledging the possible benefits and risks of nonsteroidal anti-inflammatory drug usage in chronic pain patients, and the supplementation of vitamin D may also aid in treating post-infected patients.	Vitamin D	144-153	activation induced cytidine deaminase	Homo sapiens	163-166
33463118-4	2020	In this study, the impacts of calcitriol, the active form of vitamin D, on the methylation of the conserved non-coding sequence 2 (CNS2) region of the forkhead box P3 (Foxp3) gene promoter, were evaluated.	Vitamin D	61-70	Tyr RPE enhancer	Mus musculus	131-135
32654062-15	2020	The BPPV peak in winter might be related to reduced physical activity and low vitamin D.	Vitamin D	78-87	benign paroxysmal positional vertigo	Homo sapiens	4-8
33304315-0	2020	Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta).	Vitamin D	10-19	class II, major histocompatibility complex, transactivator	Rattus norvegicus	150-156
33463118-8	2020	Vitamin D Intervention significantly (p<0.05) could increase the expression of Foxp3, IL-10, and TGF-beta1 gene in the CD4+ T cells of mice comparing with the control group.	Vitamin D	0-9	transforming growth factor, beta 1	Mus musculus	97-106
33463118-9	2020	Meanwhile, methylation of the CNS2 region of Foxp3 promoter was significantly decreased in three of ten CpG sites in the vitamin D group compared to the control group.	Vitamin D	121-130	Tyr RPE enhancer	Mus musculus	30-34
33304315-2	2020	Moreover, it has been shown that vitamin D downregulates major histocompatibility complex (MHC) class II expression in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. We here report about the impact of a dietary vitamin D supplementation on EAE in the rat strains having functionally relevant allelic variations in the CIITA (Mhc2ta) gene, a master regulator of MHC class II expression.	Vitamin D	33-42	class II, major histocompatibility complex, transactivator	Rattus norvegicus	343-348
33304315-2	2020	Moreover, it has been shown that vitamin D downregulates major histocompatibility complex (MHC) class II expression in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. We here report about the impact of a dietary vitamin D supplementation on EAE in the rat strains having functionally relevant allelic variations in the CIITA (Mhc2ta) gene, a master regulator of MHC class II expression.	Vitamin D	33-42	class II, major histocompatibility complex, transactivator	Rattus norvegicus	350-356
33289915-5	2020	Loss-of-function mutations in the genes CYP24A1 and SLC34A1, involved in vitamin D metabolism leading to hypercalcemia could not be found in this patient.	Vitamin D	73-82	solute carrier family 34 member 1	Homo sapiens	52-59
33304315-5	2020	Immunopathological studies revealed vitamin D dose-dependent effect on demyelination and inflammatory infiltration of the central nervous system (CNS), expression of MHC class II and CIITA, as well as downregulation of a range of pro-inflammatory genes.	Vitamin D	36-45	class II, major histocompatibility complex, transactivator	Rattus norvegicus	183-188
33030073-4	2020	According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk.	Vitamin D	36-45	angiotensin converting enzyme 2	Homo sapiens	66-70
33142828-4	2020	Through its interactions with a multitude of cells, vitamin D may have several ways to reduce the risk of acute respiratory tract infections and COVID-19: reducing the survival and replication of viruses, reducing risk of inflammatory cytokine production, increasing angiotensin-converting enzyme 2 concentrations, and maintaining endothelial integrity.	Vitamin D	52-61	angiotensin converting enzyme 2	Homo sapiens	267-298
33030073-4	2020	According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk.	Vitamin D	36-45	angiopoietin 1	Homo sapiens	71-78
33030073-4	2020	According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk.	Vitamin D	36-45	RIEG2	Homo sapiens	147-150
32936248-4	2020	Vitamin D deficiency was associated with increased aortic expression of osteopontin and matrix metalloproteinase-2 and -9 than controls.	Vitamin D	0-9	secreted phosphoprotein 1	Mus musculus	72-83
32902017-16	2021	Moreover, a decrease in CYP27B1 protein expression, correlated with a reduction of serum 25(OH)D2 , may indicate a compromised vitamin D metabolism after high-intensity exercise.	Vitamin D	127-136	cytochrome P450 family 27 subfamily B member 1	Equus caballus	24-31
33077435-0	2020	Recombinant Human Bone Morphogenetic Protein-2 Improves Spine Fusion in a Vitamin D-Deficient Rat Model.	Vitamin D	74-83	bone morphogenetic protein 2	Homo sapiens	18-46
33126642-9	2020	Furthermore, the expression of smad7 was downregulated by doxorubicin and improved by pirfenidone or vitamin D.	Vitamin D	101-110	SMAD family member 7	Mus musculus	31-36
32982524-8	2020	Patients suffering from hip and knee periprosthetic joint infection seem to have lower vitamin D levels compared to those with aseptic loosening of implants.	Vitamin D	87-96	hedgehog interacting protein	Homo sapiens	24-27
32899479-8	2020	In conclusion, professional basketball players had a high prevalence of vitamin D insufficiency.	Vitamin D	72-81	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	47-50
33130670-12	2020	The registered effects of vitamin D are explained with its direct stimulating of the expression and synthesis of Klotho protein and limiting FGF23 hyperproduction.	Vitamin D	26-35	fibroblast growth factor 23	Rattus norvegicus	141-146
32736832-6	2020	AT1R antagonists and vitamin D increase the expression of ACE2 independently.	Vitamin D	21-30	angiotensin converting enzyme 2	Homo sapiens	58-62
32649928-6	2020	Repression of endogenous H19 caused multiple phenotypes in cultivated murine cardiomyocytes including enhanced cardiomyocyte apoptosis, at least partly through attenuated vitamin D signalling.	Vitamin D	171-180	H19, imprinted maternally expressed transcript	Mus musculus	25-28
32603782-0	2020	Vitamin D modulates E-cadherin turnover by regulating TGF-beta and Wnt signalings during EMT-mediated myofibroblast differentiation in A459 cells.	Vitamin D	0-9	transforming growth factor alpha	Homo sapiens	54-62
32736832-7	2020	Besides, vitamin D suppresses the compensatory increase in renin levels following the inhibition of the renin-angiotensin system by AT1R antagonists.	Vitamin D	9-18	angiotensin II receptor type 1	Homo sapiens	132-136
32705172-9	2020	Whereas, vitamin D increased the protein expression of Bcl-2 and Ki67 and GPx, as well as the p-ERK1/2/ERK1/2 ratio, in NEC mice.	Vitamin D	9-18	mitogen-activated protein kinase 3	Mus musculus	96-102
32705172-9	2020	Whereas, vitamin D increased the protein expression of Bcl-2 and Ki67 and GPx, as well as the p-ERK1/2/ERK1/2 ratio, in NEC mice.	Vitamin D	9-18	mitogen-activated protein kinase 3	Mus musculus	103-109
32705172-10	2020	Furthermore, vitamin D improved cell viability, increased the ratio of p-ERK1/2/ERK1/2, inhibited apoptosis, and decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha in LPS-treated IEC-6 cells.	Vitamin D	13-22	mitogen activated protein kinase 3	Rattus norvegicus	73-79
32705172-10	2020	Furthermore, vitamin D improved cell viability, increased the ratio of p-ERK1/2/ERK1/2, inhibited apoptosis, and decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha in LPS-treated IEC-6 cells.	Vitamin D	13-22	mitogen activated protein kinase 3	Rattus norvegicus	80-86
32681429-4	2020	It is known that several androgen-metabolizing P450s (CYP3A4/5/43 and CYP2B6) and P450 enzymes (CYP2R1, CYP27A1, CYP27B1, CYP24A1, CYP3A4, CYP2J2), which are necessary for vitamin D metabolism, are expressed in the prostate.	Vitamin D	172-181	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	70-76
32584474-6	2020	Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.	Vitamin D	70-79	angiotensin converting enzyme 2	Homo sapiens	44-48
32982524-1	2020	Introduction: The aim of this study was to evaluate the effect of perioperative vitamin D levels in terms of functional results, patient-related outcome measures (PROMs) and infection risk after hip or knee replacement.	Vitamin D	80-89	hedgehog interacting protein	Homo sapiens	195-198
32485309-17	2020	In vitro cell experiments, when cell was stimulated with vitamin D, the expressions of NF-kappaB and IL-8 in cells were lower.	Vitamin D	57-66	chemokine (C-X-C motif) ligand 15	Mus musculus	101-105
32429643-10	2020	Conclusion: Vitamin D deficiency may be a contributor to recurrent pregnancy loss and suggests that the supplementation of women with Vitamin D pre-pregnancy may be protective against URPL via affecting Tregs signature genes, FOXP3 and GITR.	Vitamin D	134-143	forkhead box P3	Homo sapiens	226-231
33210060-13	2020	We suggest that in mouse the CYP2R1 repression in the liver plays an important role in obesity-induced vitamin D deficiency.	Vitamin D	103-112	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	29-35
32655486-1	2020	Objective: The correlation between benign paroxysmal positional vertigo (BPPV) and vitamin D levels was controversial.	Vitamin D	83-92	benign paroxysmal positional vertigo	Homo sapiens	73-77
32628073-7	2020	In vitamin D-sufficient mice, we found that both oral and subcutaneous administration of 1 nmol 25OHD-Gluc induced expression of Cyp24 mRNA in the colon whereas 25OHD did not.	Vitamin D	3-12	glucosidase, beta, acid	Mus musculus	102-106
32628073-10	2020	Our findings suggest that 25OHD-Gluc, a vitamin D metabolite found in bile, induces VDR-mediated responses in the colon by crossing the apical membrane of the colon epithelium.	Vitamin D	40-49	glucosidase, beta, acid	Mus musculus	32-36
32655486-11	2020	For both male and female patients with BPPV aged <40 years and female patients with BPPV aged 40-49 and 60-69 years, the lower vitamin D level is a risk factor for BPPV.	Vitamin D	127-136	benign paroxysmal positional vertigo	Homo sapiens	39-43
32655486-11	2020	For both male and female patients with BPPV aged <40 years and female patients with BPPV aged 40-49 and 60-69 years, the lower vitamin D level is a risk factor for BPPV.	Vitamin D	127-136	benign paroxysmal positional vertigo	Homo sapiens	84-88
32679840-7	2020	These effects, together with the dampening of intracellular TGF-beta, might result in an overall anti-tumor effect, thus supporting the administration of vitamin D in PDAC patients.	Vitamin D	154-163	transforming growth factor alpha	Homo sapiens	60-68
32655486-11	2020	For both male and female patients with BPPV aged <40 years and female patients with BPPV aged 40-49 and 60-69 years, the lower vitamin D level is a risk factor for BPPV.	Vitamin D	127-136	benign paroxysmal positional vertigo	Homo sapiens	84-88
31957666-2	2020	This study aimed to assess the effect of vitamin D on serum levels of proangiogenic factors, visfatin and vascular endothelial growth factor (VEGF), in patients with UC.	Vitamin D	41-50	nicotinamide phosphoribosyltransferase	Homo sapiens	93-101
32360595-0	2020	VITAMIN D REGULATION OF HAS2, HYALURONAN SYNTHESIS AND METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS.	Vitamin D	0-9	hyaluronan synthase 2	Homo sapiens	24-28
31815524-0	2020	Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK/mTOR signaling pathway.	Vitamin D	7-16	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	92-96
31815524-7	2020	VD treatment elevated p-AMPK/AMPK and decreased p-mTOR/mTOR, and it increased LC3II/LC3I, increased the protein level of Beclin-1, but decreased p62 according to Western blot analysis.	Vitamin D	0-2	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	24-28
31815524-7	2020	VD treatment elevated p-AMPK/AMPK and decreased p-mTOR/mTOR, and it increased LC3II/LC3I, increased the protein level of Beclin-1, but decreased p62 according to Western blot analysis.	Vitamin D	0-2	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	29-33
31815524-9	2020	Meanwhile, AMPK inhibitor Compound C and autophagy inhibitor 3-methyladenine (3-MA) reversed these changes following VD treatment.	Vitamin D	117-119	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	11-15
31815524-12	2020	This study provided evidence that active VD might activate chondrocyte autophagy to reduce OA inflammation via activating the AMPK/mTOR signaling pathway.	Vitamin D	41-43	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	126-130
31957666-6	2020	In patients with vitamin D insufficiency, visfatin increase was significantly lower in the intervention versus placebo group.	Vitamin D	17-26	nicotinamide phosphoribosyltransferase	Homo sapiens	42-50
32508805-13	2020	Important for cellular therapies requiring isolation of Tregs, the absolute number of beta7+CD4+CD25+FOXP3+Tregs was positively associated with 25(OH)vitamin D3 (R 2 = 0.0208, r = 0.184, p = 0.021) whereas the absolute numbers of CLA+CD4+CD25+FOXP3+Tregs in the periphery were not influenced by vitamin D status.	Vitamin D	150-159	interleukin 2 receptor subunit alpha	Homo sapiens	96-100
31957666-7	2020	There was an inverse correlation between serum 25(OH)D and visfatin in the subgroup with vitamin D insufficiency.	Vitamin D	89-98	nicotinamide phosphoribosyltransferase	Homo sapiens	59-67
32508805-13	2020	Important for cellular therapies requiring isolation of Tregs, the absolute number of beta7+CD4+CD25+FOXP3+Tregs was positively associated with 25(OH)vitamin D3 (R 2 = 0.0208, r = 0.184, p = 0.021) whereas the absolute numbers of CLA+CD4+CD25+FOXP3+Tregs in the periphery were not influenced by vitamin D status.	Vitamin D	150-159	forkhead box P3	Homo sapiens	101-106
31961707-7	2020	Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells.	Vitamin D	87-92	SMAD family member 3	Homo sapiens	167-172
31957666-8	2020	CONCLUSION: Vitamin D might be beneficial in decreasing proangiogenic factors such as visfatin in UC patients with low 25(OH)D levels.	Vitamin D	12-21	nicotinamide phosphoribosyltransferase	Homo sapiens	86-94
31953167-7	2020	Interestingly, men with impaired Leydig cell function and vitamin D deficiency had a significantly lower hCG-mediated increase in total and free testosterone compared with vitamin D sufficient men (p &lt; 0.05).	Vitamin D	58-67	hypertrichosis 2 (generalised, congenital)	Homo sapiens	105-108
31953167-7	2020	Interestingly, men with impaired Leydig cell function and vitamin D deficiency had a significantly lower hCG-mediated increase in total and free testosterone compared with vitamin D sufficient men (p &lt; 0.05).	Vitamin D	172-181	hypertrichosis 2 (generalised, congenital)	Homo sapiens	105-108
32001361-11	2020	These TF, in turn, would be interacting with regions that present polymorphisms in the general population which might explain the pathological phenotypes associated with altered vitamin D metabolism.	Vitamin D	178-187	inositol 1,4,5-triphosphate receptor 3	Mus musculus	6-8
31953167-9	2020	In conclusion, vitamin D deficiency is associated with lower testosterone/estradiol ratio in young men and lower Leydig cell sensitivity after hCG-stimulation in men with impaired gonadal function.	Vitamin D	15-24	hypertrichosis 2 (generalised, congenital)	Homo sapiens	143-146
32047095-7	2020	However, when including a set of cases with intellectual disability but not ASD (N=179), we observed a suggestive interaction between decreased levels of neonatal vitamin D and a specific maternal genotype near the PKN2 gene.	Vitamin D	163-172	protein kinase N2	Homo sapiens	215-219
32268827-11	2021	CONCLUSION: For patients with vitamin D sufficiency, the diagnostic accuracy of a single measurement of parathyroid hormone 2 h after thyroidectomy is an excellent indicator for predicting transient hypoparathyroidism.	Vitamin D	30-39	parathyroid hormone 2	Homo sapiens	104-125
32189072-1	2020	Bone cells secrete fibroblast growth factor 23 (FGF23), a hormone that inhibits the synthesis of active vitamin D (1,25(OH)2D3) and induces phosphate excretion in the kidney.	Vitamin D	104-113	fibroblast growth factor 23	Rattus norvegicus	19-46
32189072-1	2020	Bone cells secrete fibroblast growth factor 23 (FGF23), a hormone that inhibits the synthesis of active vitamin D (1,25(OH)2D3) and induces phosphate excretion in the kidney.	Vitamin D	104-113	fibroblast growth factor 23	Rattus norvegicus	48-53
32014085-2	2020	We tested the hypothesis that vitamin D deficiency increases the risk for colitis-associated colon cancer (CAC) by using an established CAC mouse model, 129-Smad3tm1Par/J(Smad3-/-) mice, which have defective transforming growth factor beta-signaling and develop colitis and CAC after the administration of dextran sodium sulfate (DSS).	Vitamin D	30-39	SMAD family member 3	Mus musculus	157-162
31982424-11	2020	Also, Vitamin D analogue significantly increased expression of Nrf2 and its downstream effectors (HO-1 and GSH), improved serum levels of total 25-hydroxyvitamin D and calcium, decreased neuro-inflammation and Amyloid beta load as well as hyperphosphorylation of MAPK-38, ERK1/2 and tau proteins were also observed.	Vitamin D	6-15	mitogen activated protein kinase 3	Rattus norvegicus	263-267
31982424-11	2020	Also, Vitamin D analogue significantly increased expression of Nrf2 and its downstream effectors (HO-1 and GSH), improved serum levels of total 25-hydroxyvitamin D and calcium, decreased neuro-inflammation and Amyloid beta load as well as hyperphosphorylation of MAPK-38, ERK1/2 and tau proteins were also observed.	Vitamin D	6-15	mitogen activated protein kinase 3	Rattus norvegicus	272-278
32014085-7	2020	Unexpectedly, DSS-treated Smad3-/- mice fed a vitamin D-null diet had improved survival, decreased colon tumor incidence (8% compared with 36%), and reduced the incidence and severity of colonic dysplasia compared with mice fed the control diet.	Vitamin D	46-55	SMAD family member 3	Mus musculus	26-31
31770575-2	2020	The megalin-cubilin endocytotic system constitutes a key transport structure, with a modulating role in vitamin D metabolism.	Vitamin D	104-113	LDL receptor related protein 2	Homo sapiens	4-11
32183826-9	2020	In addition, serum vitamin D levels were positively correlated with VDR and HOXA10 protein levels in the endometrium.	Vitamin D	19-28	homeobox A10	Homo sapiens	76-82
31705962-5	2020	Vitamin D deficiency or insufficiency also led to a decrease in expression of both myosin and actin-associated proteins (Myh1, Myh2, Myh7, Tnnc1& Tnnt1), which are essential for generation of the mechanical force needed for muscle contraction.	Vitamin D	0-9	myosin heavy chain 1	Rattus norvegicus	121-125
31705962-5	2020	Vitamin D deficiency or insufficiency also led to a decrease in expression of both myosin and actin-associated proteins (Myh1, Myh2, Myh7, Tnnc1& Tnnt1), which are essential for generation of the mechanical force needed for muscle contraction.	Vitamin D	0-9	myosin heavy chain 7	Rattus norvegicus	133-137
31705962-5	2020	Vitamin D deficiency or insufficiency also led to a decrease in expression of both myosin and actin-associated proteins (Myh1, Myh2, Myh7, Tnnc1& Tnnt1), which are essential for generation of the mechanical force needed for muscle contraction.	Vitamin D	0-9	troponin T1, slow skeletal type	Rattus norvegicus	146-151
31982424-0	2020	Active Form of Vitamin D Analogue Mitigates Neurodegenerative Changes in Alzheimer"s Disease in Rats by Targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways.	Vitamin D	15-24	mitogen activated protein kinase 3	Rattus norvegicus	138-141
31721480-11	2020	Vitamin D repletion attenuated elevated expression of beige adipose cell biomarkers (UCP-1, CD137, Tmem26, and Tbx1) as well as aberrant expression of molecules implicated in adipose tissue browning (Cox2, Pgf2alpha, and NF-kappaB pathway) in inguinal white adipose tissue in Ctns-/- mice.	Vitamin D	0-9	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	85-90
32111053-6	2020	We found a significant association between vitamin D deficiency and three SNPs of the IL7R gene, namely rs987107 (P-value = 0.047), rs3194051 (P-value = 0.03), and rs1494571 (P-value = 0.036), in addition to two SNPs of CD40, namely rs1883832 and rs6074022 (P-value = 0.049 for both).	Vitamin D	43-52	interleukin 7 receptor	Homo sapiens	86-90
32111053-6	2020	We found a significant association between vitamin D deficiency and three SNPs of the IL7R gene, namely rs987107 (P-value = 0.047), rs3194051 (P-value = 0.03), and rs1494571 (P-value = 0.036), in addition to two SNPs of CD40, namely rs1883832 and rs6074022 (P-value = 0.049 for both).	Vitamin D	43-52	CD40 molecule	Homo sapiens	220-224
31721480-11	2020	Vitamin D repletion attenuated elevated expression of beige adipose cell biomarkers (UCP-1, CD137, Tmem26, and Tbx1) as well as aberrant expression of molecules implicated in adipose tissue browning (Cox2, Pgf2alpha, and NF-kappaB pathway) in inguinal white adipose tissue in Ctns-/- mice.	Vitamin D	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	200-204
31642155-5	2020	Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry.	Vitamin D	0-9	high mobility group box 1	Homo sapiens	155-160
31629064-12	2020	Here we will review our studies that have defined a finely balanced homeostatic control mechanism employed by PTH and FGF23 with catastrophic toxicity protection from 1,25(OH)2D3 in the genomic regulation of vitamin D metabolism and its accompanied control of mineral maintenance.	Vitamin D	208-217	parathyroid hormone	Mus musculus	110-113
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	Fas ligand (TNF superfamily, member 6)	Mus musculus	300-304
32448110-0	2020	A Pre-Post Study of Vitamin D Supplements effects on Urinary megalin: The emerging predictive role of megalin in diabetic nephropathy progression.	Vitamin D	20-29	LDL receptor related protein 2	Homo sapiens	61-68
32448110-1	2020	INTRODUCTION: Megalin is a renal proximal tubular protein that reabsorbs vitamin D from glomerular filtrates.	Vitamin D	73-82	LDL receptor related protein 2	Homo sapiens	14-21
32448110-3	2020	This study aimed at testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN) patients with vitamin D hypovitaminosis.	Vitamin D	42-51	LDL receptor related protein 2	Homo sapiens	75-82
32448110-3	2020	This study aimed at testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN) patients with vitamin D hypovitaminosis.	Vitamin D	133-142	LDL receptor related protein 2	Homo sapiens	75-82
32448110-7	2020	Principally, pellet urinary megalin associated positively (p < 0.05) with vitamin D hypovitaminosis and the albumin-to-creatinine ratio (ACR) but negatively (p < 0.05) with Ca2+ and body mass index (BMI).	Vitamin D	74-83	LDL receptor related protein 2	Homo sapiens	28-35
32042409-0	2020	The Eurasian lactase persistence variant LCT-13910 C/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to sunlight.	Vitamin D	74-83	lactase	Homo sapiens	13-20
32448110-8	2020	CONCLUSION: Vitamin D supplementation could elucidate underlying pathophysiological mechanisms and a prognostic significance of urinary megalin association with DN, obesity/MetS-related dyslipidemia, and hyperglycemia modification.	Vitamin D	12-21	LDL receptor related protein 2	Homo sapiens	136-143
32448110-8	2020	CONCLUSION: Vitamin D supplementation could elucidate underlying pathophysiological mechanisms and a prognostic significance of urinary megalin association with DN, obesity/MetS-related dyslipidemia, and hyperglycemia modification.	Vitamin D	12-21	ETS variant transcription factor 3	Homo sapiens	173-177
32042409-2	2020	Individuals with this genetic lactase persistence (LP) variant generally consume more milk and have been shown to have higher levels of serum vitamin D.	Vitamin D	142-151	lactase	Homo sapiens	30-37
31145174-9	2020	Also, vitamin D supplementation significantly improved BDI (beta -2.76; 95% CI, -3.97 to -1.55; P &lt; 0.001) compared with the placebo.	Vitamin D	6-15	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	60-67
31739978-6	2020	MAIN OUTCOME MEASURE(S): Vitamin D effect in xenograft tissue was assessed by monitoring tumor size (18F-FDG positron-emission tomography/computerized tomography and macroscopic examination), cell proliferation (immunohistochemistry and quantitative real-time polymerase chain reaction [qRT-PCR]), ECM (Western blot), transforming growth factor (TGF) beta3 (qRT-PCR), and apoptosis (Westrn blot and TUNEL).	Vitamin D	25-34	transforming growth factor beta 3	Homo sapiens	318-356
32457281-0	2020	Vitamin D regulates cell viability, migration and proliferation by suppressing galectin-3 (Gal-3) gene in ovarian cancer cells.	Vitamin D	0-9	galectin 3	Homo sapiens	79-89
31739978-11	2020	Similarly, long-term high-dose vitamin D significantly reduced TGF-beta3 expression.	Vitamin D	31-40	transforming growth factor beta 3	Homo sapiens	63-72
32457281-0	2020	Vitamin D regulates cell viability, migration and proliferation by suppressing galectin-3 (Gal-3) gene in ovarian cancer cells.	Vitamin D	0-9	galectin 3	Homo sapiens	91-96
31698703-4	2019	In contrast, many of these new biological effects of vitamin D compounds, including regulation of the circadian clock and many metabolic functions, are mediated by other vitamin D metabolites, including 20-hydroxyvitamin D and 20,23-dihydroxyvitamin D, and involve their binding to the aryl hydrocarbon receptor (AhR) and retinoid-orphan receptor (ROR).	Vitamin D	53-62	aryl hydrocarbon receptor	Homo sapiens	286-311
32457281-8	2020	Gal-3 was overexpressed in ovarian cancer, which could induce the viability, migration and proliferation ability of ovarian cancer cells, and these effects were abrogated by vitamin D downregulating the expression of Gal-3 gene.	Vitamin D	174-183	galectin 3	Homo sapiens	0-5
32457281-8	2020	Gal-3 was overexpressed in ovarian cancer, which could induce the viability, migration and proliferation ability of ovarian cancer cells, and these effects were abrogated by vitamin D downregulating the expression of Gal-3 gene.	Vitamin D	174-183	galectin 3	Homo sapiens	217-222
32457281-9	2020	Therefore, our results support that vitamin D may suppress Gal-3-induced viability, migration and proliferation ability of ovarian cancer cells, which suggests that the use of vitamin D may have beneficial effects in preventing and treating ovarian cancer.	Vitamin D	36-45	galectin 3	Homo sapiens	59-64
32457281-9	2020	Therefore, our results support that vitamin D may suppress Gal-3-induced viability, migration and proliferation ability of ovarian cancer cells, which suggests that the use of vitamin D may have beneficial effects in preventing and treating ovarian cancer.	Vitamin D	176-185	galectin 3	Homo sapiens	59-64
31698703-4	2019	In contrast, many of these new biological effects of vitamin D compounds, including regulation of the circadian clock and many metabolic functions, are mediated by other vitamin D metabolites, including 20-hydroxyvitamin D and 20,23-dihydroxyvitamin D, and involve their binding to the aryl hydrocarbon receptor (AhR) and retinoid-orphan receptor (ROR).	Vitamin D	53-62	aryl hydrocarbon receptor	Homo sapiens	313-316
31698703-4	2019	In contrast, many of these new biological effects of vitamin D compounds, including regulation of the circadian clock and many metabolic functions, are mediated by other vitamin D metabolites, including 20-hydroxyvitamin D and 20,23-dihydroxyvitamin D, and involve their binding to the aryl hydrocarbon receptor (AhR) and retinoid-orphan receptor (ROR).	Vitamin D	170-179	aryl hydrocarbon receptor	Homo sapiens	286-311
31698703-4	2019	In contrast, many of these new biological effects of vitamin D compounds, including regulation of the circadian clock and many metabolic functions, are mediated by other vitamin D metabolites, including 20-hydroxyvitamin D and 20,23-dihydroxyvitamin D, and involve their binding to the aryl hydrocarbon receptor (AhR) and retinoid-orphan receptor (ROR).	Vitamin D	170-179	aryl hydrocarbon receptor	Homo sapiens	313-316
31805709-2	2019	The aim of this study was to determine whether omega-3 FA and cholecalciferol have effects on vitamin D metabolism related to CYP27B1 and 24-hydroxylase (CYP24) activities in the kidney and liver of 5/6 nephrectomy (Nx) rats.	Vitamin D	94-103	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	126-152
31635074-4	2019	The results demonstrated an improvement of the insulin signalling pathway upon treatment with vitamin D alone, with significant increases in IR, PI3K, GLUT3, GLUT4 expression levels, as well as AKT phosphorylation and glucose uptake, while GSK3beta and TAU expression levels was decreased significantly.	Vitamin D	94-103	solute carrier family 2 member 4	Homo sapiens	158-163
31805709-2	2019	The aim of this study was to determine whether omega-3 FA and cholecalciferol have effects on vitamin D metabolism related to CYP27B1 and 24-hydroxylase (CYP24) activities in the kidney and liver of 5/6 nephrectomy (Nx) rats.	Vitamin D	94-103	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	154-159
31449775-7	2019	At 6 months, Abcc6-/- mice exposed to vitamin D and calcium supplementation developed massive Randall"s plaque when compared with control Abcc6-/- mice (P &lt; 0.01).	Vitamin D	38-47	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	Mus musculus	13-18
31394158-13	2019	Treatment with vitamin D reduced Smo mRNA levels and suppressed hepatic Gli1 mRNA and protein levels.	Vitamin D	15-24	GLI family zinc finger 1	Rattus norvegicus	72-76
31635074-4	2019	The results demonstrated an improvement of the insulin signalling pathway upon treatment with vitamin D alone, with significant increases in IR, PI3K, GLUT3, GLUT4 expression levels, as well as AKT phosphorylation and glucose uptake, while GSK3beta and TAU expression levels was decreased significantly.	Vitamin D	94-103	glycogen synthase kinase 3 beta	Homo sapiens	240-248
31687010-0	2019	Assessment of Serum Vitamin D Levels in Patients with Vitiligo in Jordan: A Case-Control Study.	Vitamin D	20-29	VAMAS6	Homo sapiens	54-62
31565984-1	2021	PURPOSE: To assess the correlation between the comorbidities, such as hypertension, diabetes, thyroid disorders, hearing loss, hyperlipidemia, and vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) and to determine the high-risk groups for recurrence of symptoms.	Vitamin D	147-156	benign paroxysmal positional vertigo	Homo sapiens	210-214
31687010-4	2019	Objectives: The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo.	Vitamin D	59-68	VAMAS6	Homo sapiens	93-101
31687010-4	2019	Objectives: The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo.	Vitamin D	135-144	VAMAS6	Homo sapiens	175-183
31687010-7	2019	Serum vitamin D level was measured for both vitiligo patients and controls, results were compared, and statistical analysis was done to compare the results.	Vitamin D	6-15	VAMAS6	Homo sapiens	44-52
31582399-9	2019	CONCLUSION: Vitamin D enhances IFN-beta induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-beta alone.	Vitamin D	12-21	interferon beta 1	Homo sapiens	122-130
31554468-0	2019	Insufficiency and deficiency of vitamin D in elderly patients with fragility fractures of the hip in the Japanese population.	Vitamin D	32-41	hedgehog interacting protein	Homo sapiens	94-97
31323164-13	2019	The finding of increased anti-inflammatory property by 1,25(OH)2 D3 through promotion of VDR and miR-126-3p expression in ECs provide plausible evidence that vitamin D deficiency and downregulation of VDR expression could contribute to increased inflammatory phenotypic changes in maternal vasculature in preeclampsia.	Vitamin D	158-167	microRNA 1263	Homo sapiens	97-107
31434255-6	2019	We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9).	Vitamin D	133-142	LDL receptor related protein 2	Homo sapiens	165-169
31430707-1	2019	BACKGROUND: Although modulation of the vitamin D receptor (VDR) and endothelin-A receptor (ETAR) has previously been reported to offer renoprotection against cisplatin-induced nephrotoxicity, the possible interaction between the ET-1 and vitamin D pathways remains obscure.	Vitamin D	39-48	endothelin receptor type A	Rattus norvegicus	91-95
30813712-1	2019	OBJECTIVES: The purpose of the present study was to examine the effect of serum vitamin D concentrations on the longterm recurrence rates of benign paroxysmal positional vertigo (BPPV) patients.	Vitamin D	80-89	benign paroxysmal positional vertigo	Homo sapiens	179-183
30813712-9	2019	CONCLUSION: The present study investigated the recurrence rates of BPPV in patients for a long time without limiting the sex, age, or locations of semicircular canals and it could be seen that serum vitamin D concentrations significantly affected the recurrence of BPPV.	Vitamin D	199-208	benign paroxysmal positional vertigo	Homo sapiens	67-71
30813712-9	2019	CONCLUSION: The present study investigated the recurrence rates of BPPV in patients for a long time without limiting the sex, age, or locations of semicircular canals and it could be seen that serum vitamin D concentrations significantly affected the recurrence of BPPV.	Vitamin D	199-208	benign paroxysmal positional vertigo	Homo sapiens	265-269
31524100-7	2021	Results: Vitamin D supplementation significantly mitigated the observed aging-related reduction in brain BDNF level and activities of AChE and antioxidant enzymes and elevation in malondialdehyde level and caspase-3 activity compared to control groups.	Vitamin D	9-18	caspase 3	Rattus norvegicus	206-215
31125456-4	2019	Further, we demonstrate that the expression of CAII and CAIX in these cells is significantly up-regulated by the biologically active metabolites of vitamin A (all-trans retinoic acid) and vitamin D (1alpha,25-dihydroxyvitamin D3 ), respectively.	Vitamin D	188-197	carbonic anhydrase 9	Homo sapiens	56-60
31427443-14	2019	Furthermore, vitamin D concentration was inversely correlated with TGF-beta/Smad signaling and EMT in COPD patients, suggesting EMT as a vital mediator of COPD development in patients with low vitamin D concentrations.	Vitamin D	13-22	transforming growth factor alpha	Homo sapiens	67-75
31289106-0	2019	Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate.	Vitamin D	115-124	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	41-61
30968397-0	2019	Congenital lamellar ichthyosis in Tunisia associated with vitamin D rickets caused by a founder nonsense mutation in the TGM1 gene.	Vitamin D	58-67	transglutaminase 1	Homo sapiens	121-125
32982524-9	2020	Conclusion: The necessity of pre-operative correction of vitamin D levels to achieve better functional results and minimize the risk of infection following hip and knee arthroplasty remains inconclusive.	Vitamin D	57-66	hedgehog interacting protein	Homo sapiens	156-159
32604067-10	2020	Vitamin D and 17beta-estradiol showed neuroprotective effects by decreasing OVX-induced apoptosis and neuronal damage, regulating the AMPK/NF-kappaB signaling pathway, and reducing the proinflammatory cytokines (IL-1beta, IL-6, and TNFalpha), as well as iNOS and COX-2 in the hippocampus of OVX rats.	Vitamin D	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	263-268
32884429-0	2020	Vitamin D level and its relation to muscle and fat mass in adult male Arabs.	Vitamin D	0-9	FAT atypical cadherin 1	Homo sapiens	47-50
33842001-0	2021	Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.	Vitamin D	29-38	histidine rich calcium binding protein	Homo sapiens	68-106
33842001-3	2021	Objectives: Our study aims to investigate the ability of vitamin D in the regulation of HRC and the role of HRC playing in lung cancer.	Vitamin D	57-66	histidine rich calcium binding protein	Homo sapiens	88-91
33842001-6	2021	Results: Vitamin D inhibited HRC expression and H460 cell migration and proliferation, and promoted apoptosis compared with controls.	Vitamin D	9-18	histidine rich calcium binding protein	Homo sapiens	29-32
32839838-11	2021	CONCLUSION: This meta-analysis indicated that female gender, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency were risk factors for BPPV recurrence.	Vitamin D	128-137	benign paroxysmal positional vertigo	Homo sapiens	171-175
32824266-7	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3/calcitriol upregulated stemness-related genes (LGR5, LRIG1, SMOC2, and MSI1) in normal rectum organoids, while it downregulated differentiation marker genes (TFF2 and MUC2).	Vitamin D	11-20	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	109-113
32824266-7	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3/calcitriol upregulated stemness-related genes (LGR5, LRIG1, SMOC2, and MSI1) in normal rectum organoids, while it downregulated differentiation marker genes (TFF2 and MUC2).	Vitamin D	11-20	leucine rich repeats and immunoglobulin like domains 1	Homo sapiens	115-120
32824266-7	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3/calcitriol upregulated stemness-related genes (LGR5, LRIG1, SMOC2, and MSI1) in normal rectum organoids, while it downregulated differentiation marker genes (TFF2 and MUC2).	Vitamin D	11-20	SPARC related modular calcium binding 2	Homo sapiens	122-127
32824266-7	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3/calcitriol upregulated stemness-related genes (LGR5, LRIG1, SMOC2, and MSI1) in normal rectum organoids, while it downregulated differentiation marker genes (TFF2 and MUC2).	Vitamin D	11-20	musashi RNA binding protein 1	Homo sapiens	133-137
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	mitofusin 1	Mus musculus	114-127
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	mitofusin 1	Mus musculus	129-135
32767348-5	2020	Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections.	Vitamin D	40-49	progesterone-induced blocking factor	None	63-99
32767348-5	2020	Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections.	Vitamin D	40-49	pibf	None	101-105
32413483-9	2020	The inhibitory or stimulatory effects of vitamin D on AGE receptors are mediated by various signaling pathways, MAPK/NF-kappaB, ADAM10/MMP9 and AT1R.	Vitamin D	41-50	ADAM metallopeptidase domain 10	Homo sapiens	128-134
32413483-9	2020	The inhibitory or stimulatory effects of vitamin D on AGE receptors are mediated by various signaling pathways, MAPK/NF-kappaB, ADAM10/MMP9 and AT1R.	Vitamin D	41-50	angiotensin II receptor type 1	Homo sapiens	144-148
32706793-4	2020	We attempted to rescue the Memo1 cKO phenotype by depleting phosphate or vitamin D from the diet, but did not observe any effect on survival.	Vitamin D	73-82	mediator of cell motility 1	Mus musculus	27-32
31289106-1	2019	Metabolic deactivation of 1,25(OH)2D3 is initiated by modification of the vitamin-D side chain, as carried out by the mitochondrial cytochrome P450 24A1 (CYP24A1).	Vitamin D	74-83	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	132-152
31289106-1	2019	Metabolic deactivation of 1,25(OH)2D3 is initiated by modification of the vitamin-D side chain, as carried out by the mitochondrial cytochrome P450 24A1 (CYP24A1).	Vitamin D	74-83	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	154-161
31289106-2	2019	In addition to its role in vitamin-D metabolism, CYP24A1 is involved in catabolism of vitamin-D analogs, thereby reducing their efficacy.	Vitamin D	27-36	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	49-56
31289106-2	2019	In addition to its role in vitamin-D metabolism, CYP24A1 is involved in catabolism of vitamin-D analogs, thereby reducing their efficacy.	Vitamin D	86-95	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	49-56
31053643-8	2019	These findings define a finely balanced homeostatic mechanism involving PTH and FGF23 together with protection from 1,25(OH)2D3 toxicity that is responsible for both adaptive vitamin D metabolism and mineral regulation.	Vitamin D	175-184	parathyroid hormone	Mus musculus	72-75
31446716-4	2019	There are certain specific associations between vitamin D and IL-33/ST2 in the pathogenesis of AR.	Vitamin D	48-57	interleukin 33	Homo sapiens	62-67
30737776-12	2019	Interestingly, vitamin D showed an inverse association with proteinuria and a strong correlation with T cell MICA mRNA levels.	Vitamin D	15-24	MHC class I polypeptide-related sequence A	Homo sapiens	109-113
31275989-0	2019	Active Vitamin D and Vitamin D Receptor Help Prevent High Glucose Induced Oxidative Stress of Renal Tubular Cells via AKT/UCP2 Signaling Pathway.	Vitamin D	7-16	uncoupling protein 2	Homo sapiens	122-126
31275989-2	2019	We here tested the hypothesis that active vitamin D is able to up-regulate AKT/UCP2 signaling to alleviate oxidative stress of renal tubular cell line HK2.	Vitamin D	42-51	uncoupling protein 2	Homo sapiens	79-83
31426337-1	2019	Vitamin D (Vit.D) is involved in cellular proliferation and differentiation and regulation of the renin gene, which are important aspects of nephrogenesis and quiescence of renal health in adulthood.	Vitamin D	0-9	renin	Rattus norvegicus	98-103
30833469-8	2019	Moreover, fasting upregulated the vitamin D catabolizing CYP24A1 in the kidney through the PGC-1alpha-ERRalpha pathway.	Vitamin D	34-43	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	91-101
30950492-0	2019	The effect of dietary vitamin D supplementation on sodium-dependent phosphate uptake and expression of NaPi-IIb in the small intestine of weanling pigs.	Vitamin D	22-31	solute carrier family 34 member 2	Homo sapiens	103-111
30529760-0	2019	The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice.	Vitamin D	61-70	suppressor of mammary tumors 1	Mus musculus	4-12
30529760-0	2019	The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice.	Vitamin D	61-70	parathyroid hormone	Mus musculus	81-100
30529760-4	2019	In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway.	Vitamin D	199-208	suppressor of mammary tumors 1	Mus musculus	89-97
30529760-4	2019	In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway.	Vitamin D	199-208	parathyroid hormone	Mus musculus	219-238
30529760-4	2019	In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway.	Vitamin D	199-208	parathyroid hormone	Mus musculus	240-243
30529760-8	2019	This impairment was a result of genetic differences and occurred only in females, but the elevated PTH levels could be overcome with either calcium or vitamin D dietary supplementation.	Vitamin D	151-160	parathyroid hormone	Mus musculus	99-102
30881337-3	2019	Several studies have shown a relationship between BPPV and vitamin D deficiency, but no studies have compared serum levels of vitamin D between canalolithiasis and cupulolithiasis patients.	Vitamin D	59-68	benign paroxysmal positional vertigo	Homo sapiens	50-54
31304705-12	2019	Abnormal liver enzymes viz alanine aminotransferase, alkaline phosphatase and gamma glutamyl transferase were associated with higher rates of deficient vitamin D levels.	Vitamin D	152-161	glutamic--pyruvic transaminase	Homo sapiens	27-51
29603070-6	2019	High Ca/P/VitD treatment induced vascular calcification only in CKD rats, suppressed serum parathyroid hormone levels and led to higher sclerostin, DKK1 and FGF23 serum levels.	Vitamin D	10-14	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	148-152
29603070-6	2019	High Ca/P/VitD treatment induced vascular calcification only in CKD rats, suppressed serum parathyroid hormone levels and led to higher sclerostin, DKK1 and FGF23 serum levels.	Vitamin D	10-14	fibroblast growth factor 23	Rattus norvegicus	157-162
30399417-10	2019	However, vitamin D deficiency also resulted in more MMP12 protein in broncho-alveolar lavage and a shift in mRNA expression of MMP12/TIMP1 (p = 0.038) and MMP9/TIMP1 (p = 0.024) ratio towards more protease activity.	Vitamin D	9-18	matrix metallopeptidase 12	Mus musculus	52-57
30399417-10	2019	However, vitamin D deficiency also resulted in more MMP12 protein in broncho-alveolar lavage and a shift in mRNA expression of MMP12/TIMP1 (p = 0.038) and MMP9/TIMP1 (p = 0.024) ratio towards more protease activity.	Vitamin D	9-18	matrix metallopeptidase 12	Mus musculus	127-132
30399417-10	2019	However, vitamin D deficiency also resulted in more MMP12 protein in broncho-alveolar lavage and a shift in mRNA expression of MMP12/TIMP1 (p = 0.038) and MMP9/TIMP1 (p = 0.024) ratio towards more protease activity.	Vitamin D	9-18	matrix metallopeptidase 9	Mus musculus	155-159
30476590-0	2019	Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells.	Vitamin D	0-9	platelet activating factor receptor	Homo sapiens	101-136
30476590-0	2019	Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells.	Vitamin D	0-9	platelet activating factor receptor	Homo sapiens	138-142
30645018-0	2019	Vitamin D Protects Against Alcohol-Induced Liver Cell Injury Within an NRF2-ALDH2 Feedback Loop.	Vitamin D	0-9	aldehyde dehydrogenase 2 family member	Homo sapiens	76-81
30809535-0	2019	Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys.	Vitamin D	0-9	aquaporin 1	Mus musculus	39-44
30809535-8	2019	In addition, AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue.	Vitamin D	153-162	aquaporin 1	Mus musculus	13-18
30723466-3	2019	Feeding Cyp KO mice D- diets reduced vitamin D levels and prevented synthesis of 1,25D.	Vitamin D	37-46	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	8-11
30678199-0	2019	Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults.	Vitamin D	18-27	matrix Gla protein	Homo sapiens	54-72
30144460-8	2019	Vitamin-D treatment restored/increased DAT-ir levels (P &lt; 0.0001) in CMS rat NAc (core/ shell), compared to levels in fluoxetine treated and non-treated CMS rats.	Vitamin D	0-9	solute carrier family 6 member 3	Rattus norvegicus	39-42
31210105-8	2019	CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-gamma, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes.	Vitamin D	80-89	solute carrier family 2 member 4	Homo sapiens	196-201
31293618-5	2019	In this study, we analyzed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor, including FCER1A, MS4A2, FCER1G, VDR, GC, CYP2R1, CYP27A1, CYP27B1, CYP24A1, RXRA, RXRB, RXRG, IL4, IL4R, IL13, and IL13RA1.	Vitamin D	73-82	Fc epsilon receptor Ia	Homo sapiens	137-143
31566129-1	2019	To the best of our knowledge, this is the first study to compare circulating IL-25 and IL-33 levels with vitamin D synthesis in the literature.	Vitamin D	105-114	interleukin 33	Homo sapiens	87-92
31293618-5	2019	In this study, we analyzed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor, including FCER1A, MS4A2, FCER1G, VDR, GC, CYP2R1, CYP27A1, CYP27B1, CYP24A1, RXRA, RXRB, RXRG, IL4, IL4R, IL13, and IL13RA1.	Vitamin D	73-82	Fc epsilon receptor Ig	Homo sapiens	152-158
31275989-13	2019	Conclusions: siVDR, AKT inhibitor, and UCP2 inhibitor elevated the ROS and apoptosis of HK2 cells while attenuating the mitochondrial membrane potential, suggesting that vitamin D protects renal tubular cell from high glucose by AKT/UCP2 signaling pathway.	Vitamin D	170-179	uncoupling protein 2	Homo sapiens	39-43
30584976-10	2019	RESULTS: BDNF level increased while c-fos, Bax and caspase-3 levels decreased (p &lt; 0.0001, in all) in the hippocampal neurons of the groups that were pre-treated with vitamin D before the administration of PTZ and KA, in comparison with the PTZ and KA groups.	Vitamin D	170-179	caspase 3	Rattus norvegicus	51-60
31275989-13	2019	Conclusions: siVDR, AKT inhibitor, and UCP2 inhibitor elevated the ROS and apoptosis of HK2 cells while attenuating the mitochondrial membrane potential, suggesting that vitamin D protects renal tubular cell from high glucose by AKT/UCP2 signaling pathway.	Vitamin D	170-179	uncoupling protein 2	Homo sapiens	233-237
30661440-6	2019	Increased MAP1LC3B/LC3 expression corroborated with complete autolysosome formation detected by electron microscopy and correlated with degradation of SQSTM1/p62 in the skin following vitamin D treatment.	Vitamin D	184-193	microtubule-associated protein 1 light chain 3 beta	Mus musculus	10-18
30661440-6	2019	Increased MAP1LC3B/LC3 expression corroborated with complete autolysosome formation detected by electron microscopy and correlated with degradation of SQSTM1/p62 in the skin following vitamin D treatment.	Vitamin D	184-193	sequestosome 1	Mus musculus	151-157
30661440-6	2019	Increased MAP1LC3B/LC3 expression corroborated with complete autolysosome formation detected by electron microscopy and correlated with degradation of SQSTM1/p62 in the skin following vitamin D treatment.	Vitamin D	184-193	sequestosome 1	Mus musculus	158-161
29936100-1	2019	BACKGROUND: Recent literature suggests that children who are vitamin D deficient are uniquely susceptible to the effects of traffic-related air pollution (TRAP) exposure.	Vitamin D	61-70	CD40 antigen	Mus musculus	155-159
29936100-3	2019	OBJECTIVE: We sought to determine whether vitamin D supplementation mitigates the effect of TRAP exposure on asthma development, asthma exacerbation, and/or airway inflammation and to determine the timing of vitamin D supplementation that confers maximal health benefit.	Vitamin D	42-51	CD40 antigen	Mus musculus	92-96
29936100-6	2019	Prenatal and postnatal vitamin D supplementation significantly attenuated the development of AHR and decreased pulmonary accumulation of TH2/TH17 cells after coexposure to TRAP and allergen but not to allergen alone.	Vitamin D	23-32	CD40 antigen	Mus musculus	172-176
30661440-7	2019	Specifically, pharmacological inhibition of autophagy increased UV-induced apoptosis, suppressed M2 macs recruitment, and prevented vitamin D downregulation of Tnf and Mmp9 in the skin.	Vitamin D	132-141	matrix metallopeptidase 9	Mus musculus	168-172
29936100-8	2019	CONCLUSIONS: Our data establish that vitamin D confers protection against asthma development specifically in the context of TRAP exposure.	Vitamin D	37-46	CD40 antigen	Mus musculus	124-128
30661440-9	2019	Mechanistically, vitamin D signaling activated M2-autophagy regulators Klf4, Pparg, and Arg1.	Vitamin D	17-26	peroxisome proliferator activated receptor gamma	Mus musculus	77-82
31994527-2	2019	The results of recent research demonstrated the decrease of bone mineral density, level of vitamin D and estrogen in blood serum in patients with BPPV.	Vitamin D	91-100	benign paroxysmal positional vertigo	Homo sapiens	146-150
30661440-9	2019	Mechanistically, vitamin D signaling activated M2-autophagy regulators Klf4, Pparg, and Arg1.	Vitamin D	17-26	arginase, liver	Mus musculus	88-92
30813930-9	2019	Mechanistically, vitamin D inactivates nuclear factor-kappaB (NF-kappaB) pathway and up-regulates von Hippel-Lindau (VHL) levels, leading to HIF-1alpha reduction.	Vitamin D	17-26	von Hippel-Lindau tumor suppressor	Homo sapiens	98-115
29308676-0	2018	Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin-angiotensin inhibition.	Vitamin D	0-9	renin	Rattus norvegicus	100-105
29308676-4	2018	Vitamin D caused more reduction in monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGFbeta-1), and renin-angiotensin levels that gave better kidney function compared to the DM + L group.	Vitamin D	0-9	renin	Rattus norvegicus	123-128
29308676-5	2018	CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.	Vitamin D	12-21	renin	Rattus norvegicus	149-154
29308676-5	2018	CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.	Vitamin D	182-191	renin	Rattus norvegicus	149-154
30778159-0	2019	Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients.	Vitamin D	47-56	LDL receptor related protein 2	Homo sapiens	26-33
30778159-4	2019	This study investigated the significance of urinary C-megalin excretion in vitamin D metabolism in 153 pre-dialysis CKD patients.	Vitamin D	75-84	LDL receptor related protein 2	Homo sapiens	54-61
30527918-5	2018	A detailed understanding of the radiographic appearance of pseudofractures and their development is, therefore, necessary to aid a diagnosis of vitamin D deficiency.	Vitamin D	144-153	activation induced cytidine deaminase	Homo sapiens	125-128
31235107-9	2019	CONCLUSION: The significant negative and positive correlations of vitamin D with HbA1c and calcium, respectively suggests that vitamin D supplementation would be of potential therapeutic value in clinical settings for controlling of type 2 diabetes and more importantly its complications.	Vitamin D	66-75	hemoglobin subunit alpha 1	Homo sapiens	81-85
31235107-9	2019	CONCLUSION: The significant negative and positive correlations of vitamin D with HbA1c and calcium, respectively suggests that vitamin D supplementation would be of potential therapeutic value in clinical settings for controlling of type 2 diabetes and more importantly its complications.	Vitamin D	127-136	hemoglobin subunit alpha 1	Homo sapiens	81-85
29313404-3	2019	This study aimed to determine the relation between platelet aggregation, vitamin D and HbA1c among healthy individuals and those with Type 2 DM (T2DM).	Vitamin D	73-82	hemoglobin subunit alpha 1	Homo sapiens	87-91
30408125-10	2018	Of note, serum levels of C-reactive protein, IL-6 and soluble CD14 were significantly higher in patients with versus without severe vitamin D deficiency, and serum levels of soluble CD14 levels declined in patients with de novo supplementation of vitamin D (median 2.15 vs. 1.87 ng/mL, P = 0.002).	Vitamin D	247-256	CD14 molecule	Homo sapiens	182-186
30350999-2	2018	Vitamin D plays a critical role in the development of liver fibrosis as it inhibits transforming growth factor beta1 (TGFbeta1)-induced excessive deposition of ECM in activated hepatic stellate cells (HSCs).	Vitamin D	0-9	transforming growth factor, beta 1	Mus musculus	84-116
30400889-9	2018	Compared with non-users, vitamin D users was associated with a lower risk of death in multivariate Cox model (HR 0.91 [95% CI, 0.87-0.95]) and after propensity score matching (HR 0.94 [95% CI, 0.90-0.98]).	Vitamin D	25-34	cytochrome c oxidase subunit 8A	Homo sapiens	99-102
30350999-2	2018	Vitamin D plays a critical role in the development of liver fibrosis as it inhibits transforming growth factor beta1 (TGFbeta1)-induced excessive deposition of ECM in activated hepatic stellate cells (HSCs).	Vitamin D	0-9	transforming growth factor, beta 1	Mus musculus	118-126
30302575-10	2018	In contrast, when the recurrent BPPV groups were compared with the non-recurrent BPPV groups, the statistical analysis showed significantly lower level of vitamin D among the recurrence BPPV groups (SMD = - 4.47; 95% CI - 7.55 to - 1.29).	Vitamin D	155-164	benign paroxysmal positional vertigo	Homo sapiens	32-36
30356853-7	2018	The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17.	Vitamin D	151-160	interleukin 5	Homo sapiens	303-307
30302575-10	2018	In contrast, when the recurrent BPPV groups were compared with the non-recurrent BPPV groups, the statistical analysis showed significantly lower level of vitamin D among the recurrence BPPV groups (SMD = - 4.47; 95% CI - 7.55 to - 1.29).	Vitamin D	155-164	benign paroxysmal positional vertigo	Homo sapiens	81-85
30302575-10	2018	In contrast, when the recurrent BPPV groups were compared with the non-recurrent BPPV groups, the statistical analysis showed significantly lower level of vitamin D among the recurrence BPPV groups (SMD = - 4.47; 95% CI - 7.55 to - 1.29).	Vitamin D	155-164	benign paroxysmal positional vertigo	Homo sapiens	81-85
30302575-11	2018	CONCLUSION: Although a negative vitamin D imbalance has been reported among some BPPV patients, this review analysis failed to establish a relationship between the occurrence of BPPV and low vitamin D level.	Vitamin D	32-41	benign paroxysmal positional vertigo	Homo sapiens	81-85
30302575-12	2018	However, low vitamin D level was significantly evident among patients with recurrent episodes of BPPV.	Vitamin D	13-22	benign paroxysmal positional vertigo	Homo sapiens	97-101
30364193-7	2018	Notably, some of these regions harbor genes, such as CYP27A1, CYP2J2, GC, SNAI2, and PIM1, that are directly involved in vitamin D metabolic pathway.	Vitamin D	121-130	cytochrome P450 2J2	Bos taurus	62-68
30287811-0	2018	Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study.	Vitamin D	53-62	insulin like growth factor binding protein 2	Homo sapiens	28-35
29960865-11	2018	Plasma level of 1,25 (OH)2 D3, an active form of vitamin D, was decreased in K-G6pc-/- mice.	Vitamin D	49-58	glucose-6-phosphatase, catalytic	Mus musculus	79-83
30287811-9	2018	CONCLUSIONS: The high Vitamin D status correlated with the serological upregulation of IGFBP-2 in males and IGFBP-3 in females with obesity and may constitute surrogate markers of risk reduction of cardiometabolic disease.	Vitamin D	22-31	insulin like growth factor binding protein 2	Homo sapiens	87-94
29558205-2	2018	In both disorders, fibroblast growth factor 23 (FGF23), a bone-derived hormone regulating phosphate and vitamin D metabolism, becomes chronically elevated.	Vitamin D	104-113	fibroblast growth factor 23	Rattus norvegicus	19-46
29331667-0	2018	Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats.	Vitamin D	0-9	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	67-73
29331667-1	2018	This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration.	Vitamin D	55-64	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	91-139
29331667-1	2018	This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration.	Vitamin D	55-64	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	141-147
30216504-8	2018	Atg7 relative expression showed significant ( P &lt; 0.01) direct correlation with vitamin D serum levels and body mass index in osteoporotic group.	Vitamin D	83-92	autophagy related 7	Homo sapiens	0-4
30216977-4	2018	Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-kappaB) pathway, and immune cells.	Vitamin D	36-45	dual specificity phosphatase 10	Homo sapiens	149-173
30216977-4	2018	Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-kappaB) pathway, and immune cells.	Vitamin D	36-45	dual specificity phosphatase 10	Homo sapiens	175-179
29558205-2	2018	In both disorders, fibroblast growth factor 23 (FGF23), a bone-derived hormone regulating phosphate and vitamin D metabolism, becomes chronically elevated.	Vitamin D	104-113	fibroblast growth factor 23	Rattus norvegicus	48-53
30095022-13	2018	However, there were significant changes in muscle strength and muscle CSA from baseline in the vitamin D supplementation group.	Vitamin D	95-104	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	70-73
30138371-5	2018	RESULTS: We identified three vitamin D associated genes that were differentially expressed between RA and non-RA patients: Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) (FC = 1.47; p = 0.006), Nuclear Receptor Co-repressor 1 (NCOR1) (FC = 1,21; p = 0.005) and paraoxonases 2 (PON2) (FC = -1.37; p = 0.01).	Vitamin D	29-38	growth arrest and DNA damage inducible alpha	Homo sapiens	180-187
28823627-8	2018	BMD in the hip was independently associated with BMI (0.13 [95% CI, 0.09 to 0.18]; p < 0.001) and vitamin-D levels (-0.41 [95% CI, -0.76 to -0.06]; p = 0.03).	Vitamin D	98-107	hedgehog interacting protein	Homo sapiens	11-14
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	programmed cell death 1	Homo sapiens	136-139
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	CD80 molecule	Homo sapiens	165-169
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	CD86 molecule	Homo sapiens	171-175
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	forkhead box P3	Homo sapiens	177-182
30271082-0	2018	Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/beta-catenin signalling pathway.	Vitamin D	29-38	Wnt family member 1	Rattus norvegicus	95-98
29944852-8	2018	The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues.	Vitamin D	4-13	transforming growth factor, beta 1	Mus musculus	108-116
29944852-8	2018	The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues.	Vitamin D	4-13	matrix metallopeptidase 9	Mus musculus	121-126
30048002-8	2018	CONCLUSION: The vitamin D metabolite 1,25(OH)2 D was inversely associated with disease activity and positively associated with ACPA in treatment naive and inflammatory active early RA.	Vitamin D	16-25	proteinase 3	Homo sapiens	127-131
29742726-9	2018	Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes.	Vitamin D	104-113	insulin like growth factor binding protein 2	Homo sapiens	43-50
28004271-0	2018	Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring.	Vitamin D	9-18	peroxisome proliferator activated receptor gamma	Mus musculus	97-145
28004271-0	2018	Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring.	Vitamin D	9-18	peroxisome proliferator activated receptor gamma	Mus musculus	147-156
29467625-0	2018	Effect of Vitamin D in HN9.10e Embryonic Hippocampal Cells and in Hippocampus from MPTP-Induced Parkinson"s Disease Mouse Model.	Vitamin D	10-19	MT-RNR2 like 9 (pseudogene)	Homo sapiens	23-26
31038034-7	2018	Meta-analysis on 26 studies with 1789 type 2 diabetic subjects showed that vitamin D significantly reduced systolic blood pressure (SBP; -0.97 mmHg, 95 % CI: -1.94, -0.001, P = 0.050), but not diastolic blood pressure (DBP; -0.10 mmHg, 95 % CI: -0.22, 0.02, P = 0.087).	Vitamin D	75-84	selenium binding protein 1	Homo sapiens	132-135
31038034-8	2018	Subgroup analyses showed that administration of vitamin D in patients with baseline serum 25-hydroxy vitamin D &lt; 50 nmol/l and baseline SBP &lt; 140 mmHg significantly reduced SBP.	Vitamin D	48-57	selenium binding protein 1	Homo sapiens	139-142
31038034-8	2018	Subgroup analyses showed that administration of vitamin D in patients with baseline serum 25-hydroxy vitamin D &lt; 50 nmol/l and baseline SBP &lt; 140 mmHg significantly reduced SBP.	Vitamin D	48-57	selenium binding protein 1	Homo sapiens	179-182
31038034-9	2018	Moreover, the patients who received vitamin D without Ca co-supplementation showed significant reduction in SBP.	Vitamin D	36-45	selenium binding protein 1	Homo sapiens	108-111
31038034-11	2018	This study demonstrated that vitamin D improved SBP in type 2 diabetic patients.	Vitamin D	29-38	selenium binding protein 1	Homo sapiens	48-51
29313442-11	2018	When 25(OH) vitamin D was introduced into the mentioned model, OPG was no longer a significant predictor of TBI and was replaced in the model with vitamin D (beta = 0.009, p = 0.001).	Vitamin D	12-21	TNF receptor superfamily member 11b	Homo sapiens	63-66
29159450-5	2018	Transcripts associated with vitamin D hydroxylation (Cyp24A1, Cyp27A1, Cyp27B1) were regulated by diet at local tissue sites.	Vitamin D	28-37	cytochrome P450 family 27 subfamily A member 1	Sus scrofa	62-69
29159450-5	2018	Transcripts associated with vitamin D hydroxylation (Cyp24A1, Cyp27A1, Cyp27B1) were regulated by diet at local tissue sites.	Vitamin D	28-37	cytochrome P450 family 27 subfamily B member 1	Sus scrofa	71-78
29301185-9	2017	Multivariate regression analysis revealed that daylight outdoor hours (beta=2.948, P=0.003) and vitamin D intake (beta=2.865, P=0.003) affected the 25(OH)D level; the presence of type 1 diabetes or urinary VDBP excretion was not significant.	Vitamin D	96-105	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	114-120
29285447-0	2017	Role of Parathyroid Hormone in Determination of Fat Mass in Patients with Vitamin D Deficiency.	Vitamin D	74-83	FAT atypical cadherin 1	Homo sapiens	48-51
28703134-1	2017	Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor.	Vitamin D	55-64	SMAD family member 3	Homo sapiens	135-140
29088291-2	2017	Vitamin D is activated by 25-hydroxylase (CYP2R1) and 1-alpha-hydroxylase (CYP27B1) and is degraded by 24-hydroxylase (CYP24A1).	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Sus scrofa	75-82
29088291-5	2017	Vitamin D-metabolizing enzymes CYP2R1, CYP27B1, and CYP24A1, vitamin D binding protein GC, and vitamin D receptor VDR were expressed in the endometrium in a pregnancy stage-specific manner as well as in conceptus and chorioallantoic tissues during pregnancy.	Vitamin D	0-9	cytochrome P450 family 27 subfamily B member 1	Sus scrofa	39-46
29930537-12	2018	Cholecalciferol prevented prednisolone-elicited disturbances of the RANKL/RANK/OPG, which correlated with improved bioavailability and vitamin D signaling through VDR.	Vitamin D	135-144	TNF superfamily member 11	Rattus norvegicus	68-73
28961553-7	2017	HbA1c concentration had a slight and insignificant decrease following vitamin D intake.	Vitamin D	70-79	hemoglobin alpha, adult chain 1	Rattus norvegicus	0-4
29930537-14	2018	Our findings suggest that prednisolone-induced abnormalities in GR and RANKL/RANK/OPG signaling pathways are associated with the impairments of vitamin D auto/paracrine system in BM cells and can be ameliorated by cholecalciferol supplementation.	Vitamin D	144-153	TNF superfamily member 11	Rattus norvegicus	71-76
29217467-13	2018	The vitamin D-DBP as well as vitamin D-albumin complexes are filtered through the glomeruli and re-uptaken by megalin in the proximal tubule.	Vitamin D	4-13	LDL receptor related protein 2	Homo sapiens	110-117
29568200-5	2018	RESULTS: Employing microarray assays, a total of 267 genes were identified that were significantly up- or downregulated in PBMCs of WT-NOD2 patients, compared to healthy donors after challenge with vitamin D and/or a combination of LPS and PGN (P &lt; 0.05; threshold: &gt;= 2-fold change).	Vitamin D	198-207	nucleotide binding oligomerization domain containing 2	Homo sapiens	135-139
28576736-7	2017	Together the data may have broad implications for the immunotherapeutic properties of vitamin D in skin homeostasis, and implicate arginase-1 upregulation as a previously unreported mechanism by which vitamin D exerts anti-inflammatory effects in humans.	Vitamin D	201-210	arginase 1	Homo sapiens	131-141
29371396-1	2018	Mitochondrial cytochromes P450 (P450s) are responsible for important metabolic reactions, including steps involved in steroid and vitamin D metabolism.	Vitamin D	130-139	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	26-30
29371396-2	2018	The mitochondrial P450 24A1 (CYP24A1) is responsible for deactivation of the bioactive form of vitamin D, 1,25(OH)2D3.	Vitamin D	95-104	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	18-22
28099429-7	2017	However, Th17 cytokine suppressor IL-27 was significantly increased by hypothermia, negating the IL-27 correlation with vitamin D observed in normothermic HIE infants.	Vitamin D	120-129	interleukin 27	Homo sapiens	97-102
29037825-0	2018	Vitamin D prevents lipid accumulation in murine muscle through regulation of PPARgamma and perilipin-2 expression.	Vitamin D	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	77-86
29257249-0	2018	Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NF-kappaB signaling pathway.	Vitamin D	0-9	high mobility group box 1	Mus musculus	66-71
29067058-0	2017	Effect of Vitamin D supplementation on reduction in levels of HbA1 in patients recently diagnosed with type 2 Diabetes Mellitus having asymptomatic Vitamin D deficiency.	Vitamin D	10-19	hemoglobin subunit alpha 1	Homo sapiens	62-66
28595560-2	2018	In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.	Vitamin D	19-28	matrix metallopeptidase 2	Homo sapiens	60-64
28595560-7	2018	RESULTS: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05).	Vitamin D	41-50	matrix metallopeptidase 2	Homo sapiens	9-14
28595560-8	2018	In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04).	Vitamin D	30-39	matrix metallopeptidase 2	Homo sapiens	73-78
28595560-10	2018	CONCLUSION: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction.	Vitamin D	39-48	matrix metallopeptidase 2	Homo sapiens	74-79
29067058-0	2017	Effect of Vitamin D supplementation on reduction in levels of HbA1 in patients recently diagnosed with type 2 Diabetes Mellitus having asymptomatic Vitamin D deficiency.	Vitamin D	148-157	hemoglobin subunit alpha 1	Homo sapiens	62-66
29067058-1	2017	OBJECTIVE: To study the effect of Vitamin D supplementation on reduction in level of HbA1 in patients recently diagnosed with diabetes mellitus Type II having asymptomatic Vitamin D deficiency.	Vitamin D	34-43	hemoglobin subunit alpha 1	Homo sapiens	85-89
29653812-6	2018	Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P &lt; .05 for all).	Vitamin D	0-9	apolipoprotein C2	Homo sapiens	261-267
29067058-1	2017	OBJECTIVE: To study the effect of Vitamin D supplementation on reduction in level of HbA1 in patients recently diagnosed with diabetes mellitus Type II having asymptomatic Vitamin D deficiency.	Vitamin D	172-181	hemoglobin subunit alpha 1	Homo sapiens	85-89
28670298-4	2017	Our studies show that while transdifferentiation of preosteoblasts occurred on exposure to adipogenic media, the effect of vitamin D treatment was synergistic resulting in several hundred fold increase in adipocyte transcription factors C/EBPalpha and peroxisome proliferator-activated receptor-gamma (P &lt; 0.001) along with an increase in markers of adipogenesis and accumulation of lipid droplets in cells.	Vitamin D	123-132	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	237-247
28818673-7	2018	Our results indicate that vitamin D may influence remyelination by mechanisms involving an increase in calretinin expression and potentially other calcium binding proteins.	Vitamin D	26-35	calbindin 2	Mus musculus	103-113
28595623-12	2017	In addition, the mRNA and protein expression levels of Fas and FasL were significantly elevated in the models (P &lt; 0.05), which were significantly declined by vitamin D (P &lt; 0.05).	Vitamin D	162-171	Fas ligand	Rattus norvegicus	63-67
29237505-5	2017	Vitamin D conditioned MoDCs showed a reduced expression of co-stimulatory and antigen presenting molecules, as well as a reduced capability of endocytose ovalbumin.	Vitamin D	0-9	ovalbumin	Bos taurus	154-163
29084522-1	2017	BACKGROUND: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility.	Vitamin D	12-21	natriuretic peptide B	Homo sapiens	92-118
28595623-13	2017	CONCLUSION: Vitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in DCM rats, which might be used as a potential effective therapy for the disease.	Vitamin D	12-21	Fas ligand	Rattus norvegicus	71-75
29084522-1	2017	BACKGROUND: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility.	Vitamin D	12-21	natriuretic peptide B	Homo sapiens	120-123
28238617-1	2017	BACKGROUND: Given both lipoprotein (Lp)(a) and vitamin D have been found to be associated with coronary heart disease (CHD) risk and a biochemical link between vitamin D and cholesterol on atherosclerosis has been proposed, we hypothesised there could exist an interaction between Lp(a) and vitamin D on the severity of CHD.	Vitamin D	160-169	lipoprotein(a)	Homo sapiens	23-41
29088772-6	2017	Vitamin D treatment inhibited HFE mRNA expression, and down-regulation of HFE by transfecting small interfering RNA suppressed PC-3 human prostate cancer cell proliferation and wound healing ability.	Vitamin D	0-9	homeostatic iron regulator	Homo sapiens	30-33
28238617-1	2017	BACKGROUND: Given both lipoprotein (Lp)(a) and vitamin D have been found to be associated with coronary heart disease (CHD) risk and a biochemical link between vitamin D and cholesterol on atherosclerosis has been proposed, we hypothesised there could exist an interaction between Lp(a) and vitamin D on the severity of CHD.	Vitamin D	160-169	lipoprotein(a)	Homo sapiens	23-41
28470739-7	2017	Total vitamin D dose per kg bodyweight correlated with the down-modulation of the co-stimulatory receptor CD86 on mDCs.	Vitamin D	6-15	CD86 molecule	Homo sapiens	106-110
29088772-7	2017	In contrast, vitamin D treatment induced TUSC3 expression, and silencing TUSC3 promoted prostate cancer cell growth and migration.	Vitamin D	13-22	tumor suppressor candidate 3	Homo sapiens	41-46
27584938-3	2017	We review the data that vitamin D, a pleiotropic hormone, is essential for Lgr5 stem cell functions by signaling through the vitamin D receptor.	Vitamin D	24-33	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	75-79
28339837-0	2017	Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats.	Vitamin D	0-9	fibroblast growth factor 23	Rattus norvegicus	39-44
28339837-0	2017	Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats.	Vitamin D	0-9	fibroblast growth factor receptor 4	Rattus norvegicus	45-50
28470390-0	2017	Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.	Vitamin D	102-111	solute carrier family 34 member 1	Homo sapiens	34-41
28220196-10	2017	We found that low serum 25(OH) vitamin D level was significantly associated with the risk of total fractures (RR 1.25, 95% CI 1.06-1.43; I 2 = 31.3%, p for heterogeneity = 0.15) and hip fractures (RR 1.48, 95% CI 1.29-1.68; I 2 = 0%, p for heterogeneity = 0.51).	Vitamin D	31-40	ribonucleotide reductase catalytic subunit M1	Homo sapiens	110-114
28274898-4	2017	In this study, we aimed to investigate the role of osteoporosis and vitamin D in the etiology of BPPV by comparing BPPV patients with hospital-based controls.	Vitamin D	68-77	benign paroxysmal positional vertigo	Homo sapiens	97-101
28274898-9	2017	RESULTS: In this study, the rates of osteoporosis and vitamin D deficiency detected in BPPV patients were reasonably high.	Vitamin D	54-63	benign paroxysmal positional vertigo	Homo sapiens	87-91
28220196-10	2017	We found that low serum 25(OH) vitamin D level was significantly associated with the risk of total fractures (RR 1.25, 95% CI 1.06-1.43; I 2 = 31.3%, p for heterogeneity = 0.15) and hip fractures (RR 1.48, 95% CI 1.29-1.68; I 2 = 0%, p for heterogeneity = 0.51).	Vitamin D	31-40	ribonucleotide reductase catalytic subunit M1	Homo sapiens	197-201
28220196-11	2017	The hip fracture risk was increased by 40% for each SD decrease in serum 25(OH) vitamin D level (RR 1.40, 95% CI 1.20-1.61; I 2 = 0%, p for heterogeneity = 0.51).	Vitamin D	80-89	ribonucleotide reductase catalytic subunit M1	Homo sapiens	97-101
28143686-0	2017	Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3.	Vitamin D	0-9	CD86 molecule	Rattus norvegicus	114-118
28396965-0	2017	Racial disparity in vitamin D status may explain racial disparity in survival from estrogen and progesterone receptor-positive breast cancer.	Vitamin D	20-29	progesterone receptor	Homo sapiens	96-117
28143686-0	2017	Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3.	Vitamin D	0-9	caspase 3	Rattus norvegicus	123-132
28143686-7	2017	Administration of vitamin D in combination with HFD significantly decreased BW gain, decreased the serum levels of both calcium and CRP, increased the serum level of IL-10, improved the general histological appearance of the spleen, and decreased the expression of both CD86 and caspase-3 in the spleen in comparison with results seen in the HFD-C group.	Vitamin D	18-27	CD86 molecule	Rattus norvegicus	270-274
28143686-7	2017	Administration of vitamin D in combination with HFD significantly decreased BW gain, decreased the serum levels of both calcium and CRP, increased the serum level of IL-10, improved the general histological appearance of the spleen, and decreased the expression of both CD86 and caspase-3 in the spleen in comparison with results seen in the HFD-C group.	Vitamin D	18-27	caspase 3	Rattus norvegicus	279-288
27671249-0	2017	Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats.	Vitamin D	29-38	secreted phosphoprotein 1	Rattus norvegicus	116-127
28132894-0	2017	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Vitamin D	0-9	SREBF chaperone	Homo sapiens	103-107
28665937-8	2017	Treatment with 25 or 1,25 vitamin D decreased IL-6 and TLR9.	Vitamin D	26-35	toll like receptor 9	Homo sapiens	55-59
28665937-9	2017	CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-gamma, TLR7 and TLR9 expression.	Vitamin D	53-62	toll like receptor 9	Homo sapiens	127-131
28670298-4	2017	Our studies show that while transdifferentiation of preosteoblasts occurred on exposure to adipogenic media, the effect of vitamin D treatment was synergistic resulting in several hundred fold increase in adipocyte transcription factors C/EBPalpha and peroxisome proliferator-activated receptor-gamma (P &lt; 0.001) along with an increase in markers of adipogenesis and accumulation of lipid droplets in cells.	Vitamin D	123-132	peroxisome proliferator activated receptor gamma	Mus musculus	252-300
28368445-0	2017	Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts.	Vitamin D	0-9	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	56-61
28368445-14	2017	Inhibition of caspase-3 cleavage and ROCK1 activation, together with upregulation of eNOS expression, could be the potential cellular/molecular mechanism(s) of vitamin D protective effects on placental trophoblasts.	Vitamin D	160-169	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	37-42
27423437-0	2017	Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort.	Vitamin D	0-9	forkhead box P3	Homo sapiens	37-42
27987058-7	2017	Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2).	Vitamin D	64-73	transforming growth factor, beta 1	Mus musculus	166-174
28542407-9	2017	Multivariate analysis conformed to a marked influence on both YKL-40 and hsCRP by SigmaOCP (p&lt;0.001/p&lt;0.001) and SigmaPCBs (p&lt;0.001/p = 0.001) after adjusting for age, BMI, vitamin D, alcohol and smoking.	Vitamin D	182-191	chitinase 3 like 1	Homo sapiens	62-68
27423437-0	2017	Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort.	Vitamin D	0-9	forkhead box P3	Homo sapiens	69-74
28160341-0	2017	Vitamin D regulates immunoglobulin mucin domain molecule-4 expression in dendritic cells.	Vitamin D	0-9	LOC100508689	Homo sapiens	35-40
28065683-8	2017	DM1 and DM2 patients display a high frequency of skin abnormalities, the most common of which correlate with genotype severity and serum vitamin D levels.	Vitamin D	137-146	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	8-11
28045548-2	2017	Vitamin D (vD) induces NOD2 gene expression, enhancing immunity, while deficiency impairs intestinal epithelial integrity, increasing inflammation.	Vitamin D	0-9	nucleotide-binding oligomerization domain containing 2	Mus musculus	23-27
28727342-4	2017	Other factors may contribute to higher fracture risk in overweight patients, notably higher frequency of falls and lower bioavailability of vitamin D stoked in fat.	Vitamin D	140-149	FAT atypical cadherin 1	Homo sapiens	160-163
28395329-12	2017	These results suggest that upregulation of eNOSSer1177 and AktSer473 phosphorylation and inhibition of ROCK1 cleavage in EC and modulation of eNOS and caveolin-1 expression in MP could be plausible mechanisms of vitamin D protective effects on ECs.	Vitamin D	212-221	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	103-108
28399539-0	2017	Pigment Epithelium-Derived Factor Declines in Response to an Oral Glucose Load and Is Correlated with Vitamin D and BMI but Not Diabetes Status in Children and Young Adults.	Vitamin D	102-111	serpin family F member 1	Homo sapiens	0-33
28412753-10	2017	Vitamin D treatment, but not placebo, decreased the expression of the T cell activation marker CD69 from 42% (31 - 62%) to 33% (19 - 54%)(p = 0.01).	Vitamin D	0-9	CD69 molecule	Homo sapiens	95-99
28412753-12	2017	CONCLUSIONS: Vitamin D treatment increases CD4+CD25+int T cells ability to up-regulate PD-1 in response to activation and reduces the CD69 expression in CD patients.	Vitamin D	13-22	interleukin 2 receptor subunit alpha	Homo sapiens	47-51
28412753-12	2017	CONCLUSIONS: Vitamin D treatment increases CD4+CD25+int T cells ability to up-regulate PD-1 in response to activation and reduces the CD69 expression in CD patients.	Vitamin D	13-22	CD69 molecule	Homo sapiens	134-138
28399539-5	2017	RESULTS: PEDF was positively correlated with BMI and systolic blood pressure and negatively correlated with vitamin D.	Vitamin D	108-117	serpin family F member 1	Homo sapiens	9-13
28399539-6	2017	Upon multivariable analysis, BMI and vitamin D were independent predictors of PEDF.	Vitamin D	37-46	serpin family F member 1	Homo sapiens	78-82
28399539-7	2017	Prior to adjustment, PEDF was highest in T2D patients (7,168.9 +- 4417.4 ng/mL) and lowest in individuals with T1D (2,967.7 +- 947.1 ng/mL) but did not differ by diagnosis when adjusted for BMI and vitamin D.	Vitamin D	198-207	serpin family F member 1	Homo sapiens	21-25
28358908-8	2017	Plasma level of IL-7 was correlated with corrected QT interval (QTc) and gooseflesh skin withdrawal symptom score, while level of ADAM10 was correlated with plasma concentrations of vitamin D metabolite, nicotine metabolite, and R-methadone.	Vitamin D	182-191	ADAM metallopeptidase domain 10	Homo sapiens	130-136
28241127-5	2017	We found that vitamin D upregulated pattern recognition receptors, TLR2, and NOD2, and induced the antimicrobial human neutrophil peptides (HNP1-3) and LL-37, resulting in increased killing of pneumococci in a vitamin D receptor-dependent manner.	Vitamin D	14-23	nucleotide binding oligomerization domain containing 2	Homo sapiens	77-81
28353634-7	2017	In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1alpha, PGC1alpha, PPARalpha, VLCAD, LCAD, MCAD, and UCP1.	Vitamin D	13-22	acyl-CoA dehydrogenase, long chain	Rattus norvegicus	147-151
28241127-8	2017	Moreover, vitamin D lowered inflammatory cytokine production by infected neutrophils via IL-4 production and the induction of suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3, leading to the suppression of NF-kappaB signaling.	Vitamin D	10-19	suppressor of cytokine signaling 3	Homo sapiens	186-192
27496319-5	2016	Both in silico and previous genome-wide analyses suggested that vitamin D (VD) may regulate intestinal UGT1A expression.	Vitamin D	64-73	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	103-108
27423437-7	2017	The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio.	Vitamin D	52-61	forkhead box P3	Homo sapiens	81-86
27423437-7	2017	The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio.	Vitamin D	52-61	forkhead box P3	Homo sapiens	136-141
27423437-13	2017	The FoxP3+/IL-17A ratio in SLE patients after 6 months of vitamin D supplementation was higher than that in the baseline (p &lt; 0.001).	Vitamin D	58-67	forkhead box P3	Homo sapiens	4-9
26290513-12	2016	CONCLUSION: The presence of PSC was found to be an independent risk factor for vitamin D deficiency in UC patients with IPAA.	Vitamin D	79-88	PSC	Homo sapiens	28-31
28381350-2	2017	Intentional weight loss may alter vitamin D status and, conversely, vitamin D supplementation has been hypothesized to aid in weight loss.	Vitamin D	68-77	activation induced cytidine deaminase	Homo sapiens	119-122
26348136-3	2016	Most notably, Mmp13 is regulated by the vitamin D hormone (1,25(OH)2D3), parathyroid hormone (PTH), and several cytokines.	Vitamin D	40-49	matrix metallopeptidase 13	Mus musculus	14-19
28138564-12	2017	Expression of the extracellular receptor of vitamin D binding protein, LRP2, was positively associated with West African ancestry and inversely associated with tissue 25(OH)D concentrations in AAs.	Vitamin D	44-53	LDL receptor related protein 2	Homo sapiens	71-75
28138564-14	2017	The relationships between vitamin D binding protein LRP2 and vitamin D metabolites suggest that the prohormone is actively transported into the prostate, followed by intraprostatic conversion to the active hormone, rather than passive diffusion.	Vitamin D	26-35	LDL receptor related protein 2	Homo sapiens	52-56
28138564-14	2017	The relationships between vitamin D binding protein LRP2 and vitamin D metabolites suggest that the prohormone is actively transported into the prostate, followed by intraprostatic conversion to the active hormone, rather than passive diffusion.	Vitamin D	61-70	LDL receptor related protein 2	Homo sapiens	52-56
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	LDL receptor related protein 2	Homo sapiens	219-223
27783938-0	2016	Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.	Vitamin D	0-9	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	98-103
27903510-0	2017	Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension.	Vitamin D	0-9	angiotensin II receptor, type 1a	Rattus norvegicus	39-42
27903510-2	2017	We found that vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE.	Vitamin D	14-23	angiotensin II receptor, type 1a	Rattus norvegicus	48-51
27903510-5	2017	Therefore, we hypothesized that vitamin D would reduce PE factors during AT1-AA-induced hypertension and could lower blood pressure in a model of hypertension during pregnancy without PE features.	Vitamin D	32-41	angiotensin II receptor, type 1a	Rattus norvegicus	73-76
28367920-6	2017	Patients with vitamin D deficiency had a significantly higher neutrophil percentage, but significantly lower lymphocyte percentage and count as well as proportion of CD19 positive lymphocytes (CD19+).	Vitamin D	14-23	CD19 molecule	Homo sapiens	166-170
28367920-6	2017	Patients with vitamin D deficiency had a significantly higher neutrophil percentage, but significantly lower lymphocyte percentage and count as well as proportion of CD19 positive lymphocytes (CD19+).	Vitamin D	14-23	CD19 molecule	Homo sapiens	193-197
28894811-13	2016	CONCLUSION: Vitamin D is assumed to affect BPPV as a recurrence factor independent of age, gender, follow-up period, and type of BPPV.	Vitamin D	12-21	benign paroxysmal positional vertigo	Homo sapiens	43-47
27784812-7	2017	In this regard, some of the injurious effects of vitamin D deficiency such as myocardial hypertrophy and high blood pressure seem linked to increased renin-angiotensin activity.	Vitamin D	49-58	renin	Rattus norvegicus	150-155
27799758-0	2016	The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis.	Vitamin D	24-33	COPD	Homo sapiens	38-42
28100331-1	2017	OBJECTIVE: To investigate the changes in the mRNA and protein expression of high-mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), and nuclear factor-kappa B (NF-kappaB) in lung tissues of asthmatic mice and the interventional effect of vitamin D.	Vitamin D	246-255	high mobility group box 1	Mus musculus	103-108
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	autophagy related 16 like 1	Homo sapiens	112-119
27799758-2	2016	However, the association between serum vitamin D and COPD is not well studied.	Vitamin D	39-48	COPD	Homo sapiens	53-57
27799758-3	2016	This updated systematic review and meta-analysis aimed to assess the relationship between vitamin D and the risk, severity, and exacerbation of COPD.	Vitamin D	90-99	COPD	Homo sapiens	144-148
27973447-7	2016	Vitamin D also shifted the pro-inflammatory/anti-inflammatory balance towards an anti-inflammatory phenotype and increased the CD14 expression on monocytes (p = 0.008) in response to LPS but not HK19F stimulation.	Vitamin D	0-9	CD14 molecule	Homo sapiens	127-131
27799758-8	2016	Meta-analysis showed that lower serum vitamin D levels were found in COPD patients than in controls (SMD: -0.69, 95% CI: -1.00, -0.38, P&lt;0.001), especially in severe COPD (SMD: -0.87, 95% CI: -1.51, -0.22, P=0.001) and COPD exacerbation (SMD: -0.43, 95% CI: -0.70, -0.15, P=0.002).	Vitamin D	38-47	COPD	Homo sapiens	69-73
26290513-2	2016	Whether vitamin D levels are further lowered in patients with concomitant IPAA and primary sclerosing cholangitis (PSC) is not known.	Vitamin D	8-17	PSC	Homo sapiens	115-118
27799758-8	2016	Meta-analysis showed that lower serum vitamin D levels were found in COPD patients than in controls (SMD: -0.69, 95% CI: -1.00, -0.38, P&lt;0.001), especially in severe COPD (SMD: -0.87, 95% CI: -1.51, -0.22, P=0.001) and COPD exacerbation (SMD: -0.43, 95% CI: -0.70, -0.15, P=0.002).	Vitamin D	38-47	COPD	Homo sapiens	169-173
26290513-3	2016	The aim of this study was to evaluate the presence of PSC as a risk factor for vitamin D deficiency in patients with UC and IPAA.	Vitamin D	79-88	PSC	Homo sapiens	54-57
27799758-8	2016	Meta-analysis showed that lower serum vitamin D levels were found in COPD patients than in controls (SMD: -0.69, 95% CI: -1.00, -0.38, P&lt;0.001), especially in severe COPD (SMD: -0.87, 95% CI: -1.51, -0.22, P=0.001) and COPD exacerbation (SMD: -0.43, 95% CI: -0.70, -0.15, P=0.002).	Vitamin D	38-47	COPD	Homo sapiens	169-173
26290513-10	2016	PSC occurred in 49 (75.4%) of the 65 patients with vitamin D deficiency.	Vitamin D	51-60	PSC	Homo sapiens	0-3
27799758-9	2016	Vitamin D deficiency was associated with increased risk of COPD (OR: 1.77, 95% CI: 1.18, 2.64, P=0.006) and with COPD severity (OR: 2.83, 95% CI: 2.00, 4.00, P&lt;0.001) but not with COPD exacerbation (OR: 1.17, 95% CI: 0.86, 1.59, P=0.326).	Vitamin D	0-9	COPD	Homo sapiens	59-63
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	C-X-C motif chemokine receptor 3	Homo sapiens	72-77
27799758-9	2016	Vitamin D deficiency was associated with increased risk of COPD (OR: 1.77, 95% CI: 1.18, 2.64, P=0.006) and with COPD severity (OR: 2.83, 95% CI: 2.00, 4.00, P&lt;0.001) but not with COPD exacerbation (OR: 1.17, 95% CI: 0.86, 1.59, P=0.326).	Vitamin D	0-9	COPD	Homo sapiens	113-117
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	C-X-C motif chemokine receptor 3	Homo sapiens	94-99
27799758-9	2016	Vitamin D deficiency was associated with increased risk of COPD (OR: 1.77, 95% CI: 1.18, 2.64, P=0.006) and with COPD severity (OR: 2.83, 95% CI: 2.00, 4.00, P&lt;0.001) but not with COPD exacerbation (OR: 1.17, 95% CI: 0.86, 1.59, P=0.326).	Vitamin D	0-9	COPD	Homo sapiens	113-117
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	C-C motif chemokine receptor 4	Homo sapiens	173-177
27799758-11	2016	CONCLUSION: Serum vitamin D levels were inversely associated with COPD risk, severity, and exacerbation.	Vitamin D	18-27	COPD	Homo sapiens	66-70
27799758-12	2016	Vitamin D deficiency is associated with increased risk of COPD and severe COPD but not with COPD exacerbation.	Vitamin D	0-9	COPD	Homo sapiens	58-62
27799758-12	2016	Vitamin D deficiency is associated with increased risk of COPD and severe COPD but not with COPD exacerbation.	Vitamin D	0-9	COPD	Homo sapiens	74-78
27799758-12	2016	Vitamin D deficiency is associated with increased risk of COPD and severe COPD but not with COPD exacerbation.	Vitamin D	0-9	COPD	Homo sapiens	74-78
27574921-5	2016	Although, the majority of vitamin D metabolism is mediated by 24-hydoxylase (CYP24A1), it is not clear why the formation of calcitroic acid was not observed in the presence of recombinant CYP24A1 enzyme.	Vitamin D	26-35	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	77-84
27799758-13	2016	It is worth considering assay methods in the heterogeneity sources analysis of association between vitamin D deficiency and COPD.	Vitamin D	99-108	COPD	Homo sapiens	124-128
27785371-9	2016	Osteoclast fusion transcripts transmembrane 7 subfamily member 4 (tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1 (nfatc1) where downregulated in response to vitamin D metabolites.	Vitamin D	171-180	dendrocyte expressed seven transmembrane protein	Homo sapiens	30-64
28531780-0	2016	Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study.	Vitamin D	0-9	VAMAS6	Homo sapiens	78-86
28531780-0	2016	Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study.	Vitamin D	41-50	VAMAS6	Homo sapiens	78-86
28531780-3	2016	Little is known about the association of vitiligo and vitamin D.	Vitamin D	54-63	VAMAS6	Homo sapiens	41-49
28531780-4	2016	We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients.	Vitamin D	37-46	VAMAS6	Homo sapiens	81-89
28531780-13	2016	Oral vitamin D supplementation might be useful for children with vitiligo who are also deficient in vitamin D.	Vitamin D	5-14	VAMAS6	Homo sapiens	65-73
27785371-9	2016	Osteoclast fusion transcripts transmembrane 7 subfamily member 4 (tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1 (nfatc1) where downregulated in response to vitamin D metabolites.	Vitamin D	171-180	dendrocyte expressed seven transmembrane protein	Homo sapiens	66-72
27198744-7	2016	The mean maternal vitamin D level was significantly lower in the NTD group (20.65+-10.25nmol/L) than in the control group (28.30+-13.82nmol/L; P&lt;0.001).	Vitamin D	18-27	fuzzy planar cell polarity protein	Homo sapiens	65-68
27399878-0	2016	The NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration in Male Mice.	Vitamin D	32-41	cytochrome b-245, beta polypeptide	Mus musculus	18-22
27399878-10	2016	Vitamin D in a Nox2-dependent manner activated MAPKs, and these are known to contribute to SDF1 induction.	Vitamin D	0-9	cytochrome b-245, beta polypeptide	Mus musculus	15-19
27399878-10	2016	Vitamin D in a Nox2-dependent manner activated MAPKs, and these are known to contribute to SDF1 induction.	Vitamin D	0-9	chemokine (C-X-C motif) ligand 12	Mus musculus	91-95
27207502-13	2016	CONCLUSIONS: Our results, indicating the inhibition of cytokine levels and the regulation of claudin-2, claudin-4, and claudin-7 by 1,25(OH)2D3, suggest that vitamin D may represent a potential therapeutic agent for the treatment of active UC.	Vitamin D	158-167	claudin 7	Homo sapiens	119-128
27198744-8	2016	Vitamin D deficiency was recorded for 53 (78%) women in the NTD group and 39 (61%) in the control group.	Vitamin D	0-9	fuzzy planar cell polarity protein	Homo sapiens	60-63
27632366-1	2016	The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species.	Vitamin D	82-91	transient receptor potential cation channel subfamily V member 5	Canis lupus familiaris	141-146
27198744-9	2016	Vitamin D insufficiency was recorded for 15 (22%) women in the NTD group and 20 (31%) in the control group.	Vitamin D	0-9	fuzzy planar cell polarity protein	Homo sapiens	63-66
27222384-6	2016	Compared to either factor alone, treatment of fibroblasts with both vitamin D and low concentration of TGFbeta1 increased gene expression of TGFbeta1, connective tissue growth factor, and fibronectin 1, and enhanced fibroblast migration, myofibroblast formation, and collagen production.	Vitamin D	68-77	cellular communication network factor 2	Homo sapiens	151-182
27483306-10	2016	CONCLUSIONS: Higher vitamin D status may protect the endothelium through reduced dyslipidaemia and increased HGF.	Vitamin D	20-29	hepatocyte growth factor	Homo sapiens	109-112
27790417-9	2016	RANKL had a significant decrease in calcium plus vitamin D plus Estrogen group compared to control and calcium plus vitamin D groups.	Vitamin D	49-58	TNF superfamily member 11	Rattus norvegicus	0-5
27790417-9	2016	RANKL had a significant decrease in calcium plus vitamin D plus Estrogen group compared to control and calcium plus vitamin D groups.	Vitamin D	116-125	TNF superfamily member 11	Rattus norvegicus	0-5
27790417-12	2016	CONCLUSION: The results showed that intake of calcium and vitamin D and estrogen at determined dose led to an increase in OPG and RANKL cytokines reduction which ultimately led to an increase in bone mineral density.	Vitamin D	58-67	TNF superfamily member 11	Rattus norvegicus	130-135
27579147-7	2016	Bioinformatic analysis revealed multiple candidate genes for both PTH and vitamin D, including CUBN, MGAT3, and NFKBIA.	Vitamin D	74-83	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	101-106
27579147-8	2016	Targeted association analysis identified NEBL as a candidate gene for vitamin D and FNDC3B for PTH.	Vitamin D	70-79	nebulette	Homo sapiens	41-45
27579147-9	2016	We observed significant associations between a variant in MXD1 and vitamin D only when an interaction with the delta15N value was included.	Vitamin D	67-76	MAX dimerization protein 1	Homo sapiens	58-62
32699567-3	2016	In this study, we characterize the effects of vitamin D-deficiency and sufficiency on the cutaneous expression of TREM-1, TREM-2, VDR, HMGB1, and RAGE.	Vitamin D	46-55	MOK protein kinase	Sus scrofa	146-150
26994969-2	2016	We found that calbindin-D9k null (knockout) pups generated from calbindin-D9k knockout females fed a vitamin D-deficient, low-calcium (0.47%) diet develop transient alopecia.	Vitamin D	101-110	S100 calcium binding protein G	Mus musculus	14-27
27624533-1	2016	Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphorus (P) and vitamin D metabolism.	Vitamin D	80-89	fibroblast growth factor 23	Rattus norvegicus	0-27
27624533-1	2016	Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphorus (P) and vitamin D metabolism.	Vitamin D	80-89	fibroblast growth factor 23	Rattus norvegicus	29-34
27624533-4	2016	We also assessed changes in renal mRNA expression of vitamin D metabolizing enzymes and type II sodium-phosphate (Na/Pi) cotransporters, since these are regulated by FGF23.	Vitamin D	53-62	fibroblast growth factor 23	Rattus norvegicus	166-171
27757201-13	2016	CONCLUSION: The findings of this study indicate that the normalization of serum vitamin D significantly reduces BPPV recurrences.	Vitamin D	80-89	benign paroxysmal positional vertigo	Homo sapiens	112-116
30603307-8	2017	Moreover, vitamin D deficiency decreased the mRNA levels of insulin-like growth factor-1, fibroblast growth factor-2 and osteoglycin in muscle of diabetic mice.	Vitamin D	10-19	insulin-like growth factor 1	Mus musculus	60-116
27133915-5	2016	The combination of vitamin D &amp; resveratrol completely reversed tunicamycin and Abeta25-35 induced cytotoxicity in SH-SY5Y cells, as well as elevation in ER stress markers (i.e.GRP78, p-eIF2alpha and CHOP), insulin signaling disruption (i.e. elevation in p-IRS-1serine307 and reduction in p-Akt serine473) and tau phosphorylation (i.e. reduction in p-GSK3beta serine9, and elevation in p-Tau serine396 &amp;404).	Vitamin D	19-28	glycogen synthase kinase 3 beta	Homo sapiens	354-362
26994969-9	2016	Our results show that in calbindin-D9k knockout pups, a maternal vitamin D-deficient/low-calcium diet leads to transient noncicatricial alopecia.	Vitamin D	65-74	S100 calcium binding protein G	Mus musculus	25-38
27382272-9	2016	CONCLUSION: When elderly patients have coronary artery disease with AECOPD, vitamin D levels were obviously lower and were negatively correlated with the BNP.	Vitamin D	76-85	natriuretic peptide B	Homo sapiens	154-157
27314336-7	2016	Furthermore, our study confirms a deregulation of the vitamin D system: among the transcription factors that potentially regulate the deregulated genes, we find TCF3 and SP1 that are both involved in vitamin D3-induced p27Kip1 expression.	Vitamin D	54-63	transcription factor 3	Homo sapiens	161-165
27173620-9	2016	We concluded that liver has the capacity for an active vitamin D catabolism in different populations of liver cells, especially in sinusoidal endothelial cells, through an expression of CYP24.	Vitamin D	55-64	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	186-191
26691308-0	2016	Vitamin D improves diabetic nephropathy in rats by inhibiting renin and relieving oxidative stress.	Vitamin D	0-9	renin	Rattus norvegicus	62-67
26691308-2	2016	Vitamin D may be important in maintaining podocyte health, preventing epithelial-to-mesenchymal transformation, and suppressing renin gene expression and inflammation, but its mechanism requires clarification.	Vitamin D	0-9	renin	Rattus norvegicus	128-133
26691308-8	2016	Vitamin D inhibited the compensatory increase in renin expression.	Vitamin D	0-9	renin	Rattus norvegicus	49-54
26691308-12	2016	CONCLUSIONS: Vitamin D combined with angiotensin II type 1 receptor blockers exerts a synergistic effect on the treatment of DN, not only by inhibiting renin but also by reducing oxidative stress and increasing the renal antioxidant capacity.	Vitamin D	13-22	renin	Rattus norvegicus	152-157
27026514-0	2016	Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma.	Vitamin D	64-73	Fc epsilon receptor II	Homo sapiens	38-42
27041081-7	2016	Furthermore, both vitamin D forms induced an expansion of CD25hi cells and upregulated their expression of CTLA-4 and Foxp3 regulatory markers.	Vitamin D	18-27	interleukin 2 receptor subunit alpha	Homo sapiens	58-62
27041081-7	2016	Furthermore, both vitamin D forms induced an expansion of CD25hi cells and upregulated their expression of CTLA-4 and Foxp3 regulatory markers.	Vitamin D	18-27	forkhead box P3	Homo sapiens	118-123
27001276-10	2016	Taken together, we provide evidence that vitamin D balance in the presence of hyperglycemia is strongly associated with serum adiponectin levels and reduced renal renin-angiotensin system signaling.	Vitamin D	41-50	renin	Rattus norvegicus	163-168
26462119-11	2016	The novel findings provide the conceptual support that persistent FOXO1 activation may be responsible for insulin resistance and impaired glucose metabolism in vitamin D signaling-deficient mice, as well as evidence for the utility of vitamin D supplementation for intervention in DM2.	Vitamin D	235-244	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	281-284
26932723-0	2016	Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer"s disease.	Vitamin D	0-9	insulin-like growth factor 1	Mus musculus	34-38
26778482-6	2016	In vivo, LC supplementation increased GSH and protein and mRNA expression of VDBP and vitamin D 25-hydroxylase (CYP2R1) in the liver, and simultaneously resulted in elevated blood levels of LC and GSH, as well as increases in VDBP and 25(OH) vitamin D levels, and decreased inflammatory biomarkers in ZDF rats compared with those in placebo-supplemented ZDF rats consuming a similar diet.	Vitamin D	86-95	cytochrome P450, family 2, subfamily r, polypeptide 1	Rattus norvegicus	112-118
26448381-10	2015	This vitamin D rise was associated with highly significant improvement in concentrations of fasting blood sugar (FBS), fasting insulin, HbA1c%, and HOMA-beta-cell function in diabetic and non-diabetic controls.	Vitamin D	5-14	hemoglobin subunit alpha 1	Homo sapiens	136-140
27121020-8	2016	The expression of pulmonary surfactant-associated protein B (SP-B) and peroxiredoxin 5 (PRDX5) were reduced in P7 lungs of vitamin D deficient mice, while the production of collagen type Iota alpha 1 (COL1A1) was higher in lungs of vitamin D deficient mice.	Vitamin D	123-132	peroxiredoxin 5	Mus musculus	71-86
27121020-8	2016	The expression of pulmonary surfactant-associated protein B (SP-B) and peroxiredoxin 5 (PRDX5) were reduced in P7 lungs of vitamin D deficient mice, while the production of collagen type Iota alpha 1 (COL1A1) was higher in lungs of vitamin D deficient mice.	Vitamin D	123-132	peroxiredoxin 5	Mus musculus	88-93
26430465-10	2015	Vitamin-D intake and resistance training increased strength/CSA in elderly compared to young (p = 0.008).	Vitamin D	0-9	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	60-63
27121020-8	2016	The expression of pulmonary surfactant-associated protein B (SP-B) and peroxiredoxin 5 (PRDX5) were reduced in P7 lungs of vitamin D deficient mice, while the production of collagen type Iota alpha 1 (COL1A1) was higher in lungs of vitamin D deficient mice.	Vitamin D	232-241	peroxiredoxin 5	Mus musculus	88-93
26376849-8	2015	Furthermore, early signs of emphysema were only observed in CS-exposed vitamin D deficient mice, which was accompanied by elevated levels of MMP-12 in the lung.	Vitamin D	71-80	matrix metallopeptidase 12	Mus musculus	141-147
27121284-0	2016	Vitamin D levels in children with familial Mediterranean fever.	Vitamin D	0-9	MEFV innate immuity regulator, pyrin	Homo sapiens	34-62
27121284-1	2016	BACKGROUND: This study aimed to determine whether vitamin D deficiency is more common in children with familial Mediterranean fever (FMF) than in healthy individuals.	Vitamin D	50-59	MEFV innate immuity regulator, pyrin	Homo sapiens	103-131
26392765-0	2015	Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis.	Vitamin D	0-9	COPD	Homo sapiens	56-60
26977044-4	2016	The aim of this study was to measure the influence of the amount of two SPF 30 sunscreens on pre-vitamin D formation in a cuvette with 7-dehydrocholesterol.	Vitamin D	97-106	survival motor neuron domain containing 1	Homo sapiens	72-78
26392765-12	2015	The four randomized studies showed that vitamin D intake provided benefit for COPD patients.	Vitamin D	40-49	COPD	Homo sapiens	78-82
26392765-14	2015	Vitamin D supplementation may prevent COPD exacerbation.	Vitamin D	0-9	COPD	Homo sapiens	38-42
26700731-0	2016	Vitamin D modulates tissue factor and protease-activated receptor 2 expression in vascular smooth muscle cells.	Vitamin D	0-9	F2R like trypsin receptor 1	Homo sapiens	38-67
24973969-1	2015	Several studies indicated the association between benign paroxysmal positional vertigo (BPPV) with osteoporosis and vitamin D deficiency implying that abnormal calcium metabolism may underlie BPPV.	Vitamin D	116-125	benign paroxysmal positional vertigo	Homo sapiens	88-92
26878191-1	2016	FGF23 regulates renal phosphate and vitamin D metabolism.	Vitamin D	36-45	fibroblast growth factor 23	Rattus norvegicus	0-5
24973969-1	2015	Several studies indicated the association between benign paroxysmal positional vertigo (BPPV) with osteoporosis and vitamin D deficiency implying that abnormal calcium metabolism may underlie BPPV.	Vitamin D	116-125	benign paroxysmal positional vertigo	Homo sapiens	192-196
24973969-2	2015	The aim of the present study is to confirm the correlation between BPPV and both decrease in bone mineral density (BMD) and vitamin D deficiency.	Vitamin D	124-133	benign paroxysmal positional vertigo	Homo sapiens	67-71
24973969-13	2015	Moreover, low levels of vitamin D were related to development of BPPV while very low levels were associated with recurrence of BPPV.	Vitamin D	24-33	benign paroxysmal positional vertigo	Homo sapiens	65-69
26765264-0	2016	The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.	Vitamin D	77-86	T cell activation RhoGTPase activating protein	Homo sapiens	44-49
24973969-14	2015	The co-occurrence of two morbidities is not by itself supportive of a relationship, but the cumulating studies correlating between BPPV and both vitamin D deficiency and low BMD indicate the investigation and treatment of those disorders in cases with recurrent BPPV.	Vitamin D	145-154	benign paroxysmal positional vertigo	Homo sapiens	131-135
26765264-0	2016	The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.	Vitamin D	77-86	interleukin 2 receptor subunit alpha	Homo sapiens	54-59
26765264-5	2016	We identify IL2RA and TAGAP as novel vitamin D target genes.	Vitamin D	37-46	interleukin 2 receptor subunit alpha	Homo sapiens	12-17
26765264-5	2016	We identify IL2RA and TAGAP as novel vitamin D target genes.	Vitamin D	37-46	T cell activation RhoGTPase activating protein	Homo sapiens	22-27
26413189-0	2015	A vitamin D analog inhibits Th2 cytokine- and TGFbeta -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis.	Vitamin D	2-11	transforming growth factor, beta 1	Mus musculus	46-53
26413189-0	2015	A vitamin D analog inhibits Th2 cytokine- and TGFbeta -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis.	Vitamin D	121-130	transforming growth factor, beta 1	Mus musculus	46-53
26927460-1	2016	INTRODUCTION: This study was aimed to determine the relationship between vitamin D and soluble vitamin D receptor (VDR) levels and brucellosis, a common infection in Turkey, in which the cellular immune system is important in the course of the disease.	Vitamin D	73-82	vitamin D3 receptor	Meleagris gallopavo	95-113
26413189-11	2015	In addition to the previously reported immunosuppressive effect, the vitamin D analog OCT might be effective to treat scleroderma, in part through inhibition of Th2 cytokine- and TGFbeta-induced POSTN expression.	Vitamin D	69-78	transforming growth factor, beta 1	Mus musculus	179-186
25312909-0	2015	Modulating effects of WT1 on interferon-beta-vitamin D association in MS.	Vitamin D	45-54	interferon beta 1	Homo sapiens	29-44
26130027-6	2016	Total MGP was 19 % higher with calcimimetics (21.5 vs. 18.1 mcg/L, p = 0.04) and 54 % higher with calcium acetate (27.9 vs. 18.1 mcg/L, p = 0.003); no difference was found with vitamin D analogs (21.1 vs. 18.3 mcg/L, p = 0.43).	Vitamin D	177-186	matrix Gla protein	Homo sapiens	6-9
25312909-1	2015	OBJECTIVE: To investigate whether those genes involved in the vitamin D pathway modulate the relationship between 25-hydroxyvitamin D (25(OH)D) and IFN-beta, the relationship between IFN-beta and sun in predicting 25(OH)D, and the interaction between IFN-beta and 25(OH)D in modulating relapse risk in patients with MS. METHODS: Prospective cohort study of 169 participants with MS and genotype data followed 2002-2005.	Vitamin D	62-71	interferon beta 1	Homo sapiens	148-156
25312909-10	2015	These findings indicate that WT1 variants may play a role in altering the effects of IFN-beta on vitamin D in MS.	Vitamin D	97-106	interferon beta 1	Homo sapiens	85-93
26793305-10	2015	YKL-40 level decreased with rising vitamin D level in Inuit (Inuit diet P = 0 002; mixed diet P = 0 011).	Vitamin D	35-44	chitinase 3 like 1	Homo sapiens	0-6
25350782-8	2015	CONCLUSION: The findings of the study showed that the weekly administration of 50 000 IU of oral vitamin D for 8 weeks as an adjunct supplement of antihypertensive drugs in patients with vitamin D deficiency could help prevent vitamin D deficiency and aid control of SBP, DBP, and MAP.	Vitamin D	97-106	selenium binding protein 1	Homo sapiens	267-270
26793305-11	2015	YKL-40 was lower in groups with higher vitamin D levels after adjusting for other factors known to influence inflammation (P &lt; 0 001).	Vitamin D	39-48	chitinase 3 like 1	Homo sapiens	0-6
26793305-14	2015	Vitamin D levels were inversely associated with YKL-40 levels, but no association with hsCRP was found.	Vitamin D	0-9	chitinase 3 like 1	Homo sapiens	48-54
25457999-0	2015	Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33.	Vitamin D	0-9	interleukin 33	Homo sapiens	71-76
27141540-1	2015	BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.	Vitamin D	12-21	insulin receptor	Homo sapiens	201-205
25294851-0	2015	The induction of C/EBPbeta contributes to vitamin D inhibition of ADAM17 expression and parathyroid hyperplasia in kidney disease.	Vitamin D	42-51	CCAAT enhancer binding protein beta	Homo sapiens	17-26
25294851-1	2015	BACKGROUND: In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-alpha (TGFalpha) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid hormone (PTH) and also reductions in vitamin D receptor (VDR) that limit vitamin D suppression of SHPT.	Vitamin D	255-264	transforming growth factor alpha	Homo sapiens	118-126
26214382-8	2015	Local androgen regulation in the skin of the CYP11A1 gene, which encodes a crucial enzyme that metabolizes cholesterol, 7DHC, and vitamin D, appeared to contribute to the gender differences in UVB-induced vitamin D production and to its reversal of vitamin D deficiency.	Vitamin D	130-139	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	45-52
25897656-3	2015	Porcine rotavirus (PRV) infection alone resulted in a significant increase in CYP27B1 mRNA, which augmented the production of active vitamin D.	Vitamin D	133-142	cytochrome P450 family 27 subfamily B member 1	Sus scrofa	78-85
26214382-8	2015	Local androgen regulation in the skin of the CYP11A1 gene, which encodes a crucial enzyme that metabolizes cholesterol, 7DHC, and vitamin D, appeared to contribute to the gender differences in UVB-induced vitamin D production and to its reversal of vitamin D deficiency.	Vitamin D	205-214	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	45-52
26214382-8	2015	Local androgen regulation in the skin of the CYP11A1 gene, which encodes a crucial enzyme that metabolizes cholesterol, 7DHC, and vitamin D, appeared to contribute to the gender differences in UVB-induced vitamin D production and to its reversal of vitamin D deficiency.	Vitamin D	205-214	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	45-52
25961000-9	2015	The above results demonstrate that active vitamin D promoted M1 phenotype switching to M2 via the VDR-PPARgamma pathway.	Vitamin D	42-51	peroxisome proliferator activated receptor gamma	Mus musculus	102-111
26392310-5	2015	At two months of age, Pmca1(EKO) mice fed a 0.81% calcium, 0.34% phosphorus, normal vitamin D diet had reduced whole body bone mineral density (P &lt; 0.037), and reduced femoral bone mineral density (P &lt; 0.015).	Vitamin D	84-93	ATPase, Ca++ transporting, plasma membrane 1	Mus musculus	22-27
25551576-7	2014	Our data are consistent with involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon and vitamin D.	Vitamin D	146-155	leukocyte immunoglobulin like receptor B2	Homo sapiens	53-57
24781050-0	2014	Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn"s disease.	Vitamin D	23-32	nucleotide binding oligomerization domain containing 2	Homo sapiens	36-40
24781050-3	2014	Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene expression and its downstream function.	Vitamin D	0-9	nucleotide binding oligomerization domain containing 2	Homo sapiens	76-80
24961547-2	2014	This study examined the hypothesis that the levels of vitamin D and LC correlate with those of GSH in the blood of type 2 diabetic patients (T2D), and that vitamin D and LC upregulate glutamate-cysteine ligase (GCLC), which catalyzes GSH biosynthesis, in cultured monocytes.	Vitamin D	156-165	glutamate-cysteine ligase catalytic subunit	Homo sapiens	211-215
24961547-8	2014	Cell culture studies demonstrate that supplementation with vitamin D and LC significantly increased GCLC expression and GSH formation in control and high-glucose-treated monocytes.	Vitamin D	59-68	glutamate-cysteine ligase catalytic subunit	Homo sapiens	100-104
24644045-1	2014	UNLABELLED: The association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated, despite experimental evidence supporting an important role of vitamin D in liver pathophysiology.	Vitamin D	36-45	HCC	Homo sapiens	83-86
25089825-5	2014	Fgfr1Dmp1-cKO-null mice exhibited a 50% reduction in FGF23 expression in bone and 3-fold reduction in serum FGF23 concentrations, as well as reductions in sclerostin (Sost), phosphate regulating endopeptidase on X chromosome (PHEX or Phex), matrix extracellular phosphoglycoprotein (Mepe), and Dmp1 transcripts, but had no demonstrable alterations in phosphate or vitamin D homeostasis or skeletal morphology.	Vitamin D	364-373	fibroblast growth factor receptor 1	Mus musculus	0-13
25089825-5	2014	Fgfr1Dmp1-cKO-null mice exhibited a 50% reduction in FGF23 expression in bone and 3-fold reduction in serum FGF23 concentrations, as well as reductions in sclerostin (Sost), phosphate regulating endopeptidase on X chromosome (PHEX or Phex), matrix extracellular phosphoglycoprotein (Mepe), and Dmp1 transcripts, but had no demonstrable alterations in phosphate or vitamin D homeostasis or skeletal morphology.	Vitamin D	364-373	dentin matrix protein 1	Mus musculus	5-9
25090260-2	2014	The purpose of this study was to measure the vitamin D status of children with Familial Mediterranean Fever (FMF) and compare it to their healthy peers.	Vitamin D	45-54	MEFV innate immuity regulator, pyrin	Homo sapiens	79-107
24894000-10	2014	Improved vitamin D status as a result of feeding 25OHD3 increased the number of mitotically active (Pax7+;BrdU+) SC (P = 0.01) and tended to increase the density of Pax7+ SC (P = 0.07) in the PM muscles of broilers on d 21 and 35, respectively.	Vitamin D	9-18	paired box 7	Gallus gallus	100-104
24894000-10	2014	Improved vitamin D status as a result of feeding 25OHD3 increased the number of mitotically active (Pax7+;BrdU+) SC (P = 0.01) and tended to increase the density of Pax7+ SC (P = 0.07) in the PM muscles of broilers on d 21 and 35, respectively.	Vitamin D	9-18	paired box 7	Gallus gallus	165-169
24854954-8	2014	In primary human peripheral blood mononuclear cells from 71 prediabetic subjects of a vitamin D(3) intervention study (VitDmet) CD97, LRRC8A, SLC37A2 and NRIP1 can be used as transcriptomic biomarkers for classifying human individuals for their possible benefit from vitamin D(3) supplementation.	Vitamin D	86-95	nuclear receptor interacting protein 1	Homo sapiens	154-159
24854954-9	2014	In particular, NRIP1 exceeds the potential of the previously identified marker CD14 by more than 40% and seems to be a well-suited molecular marker for the vitamin D(3) status in the hematopoietic system.	Vitamin D	156-165	nuclear receptor interacting protein 1	Homo sapiens	15-20
25237378-3	2014	The aim of the current study therefore is to investigate if vitamin D modulates the expression and activation of MMP-2 and MMP-9 in human lung fibroblasts (HFL-1) cells.	Vitamin D	60-69	matrix metallopeptidase 2	Homo sapiens	113-118
24895985-1	2014	PURPOSE: In the context of osteoimmunology in Crohn"s disease, an association was hypothesized among vitamin D and members of the TNF-alpha family, known as the RANK (receptor-activator of nuclear factor- kappaB)-RANK ligand-osteoprotegerin pathway.	Vitamin D	101-110	TNF receptor superfamily member 11b	Homo sapiens	225-240
24072555-1	2014	BACKGROUND: Vitamin D attenuates uremic cardiac hypertrophy, possibly by suppressing the myocardial renin-angiotensin system (RAS) and fibroblast growth factors (FGFs).	Vitamin D	12-21	renin	Rattus norvegicus	100-105
24262718-8	2014	In addition, vitamin D treatment significantly (P &lt; .05) decreased monocyte-induced p-IkappaBalpha in cytosol and NFkappaB-p65 in the nucleus and increased IkappaBalpha in cytosol in UtSM cells.	Vitamin D	13-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	117-129
24381012-8	2014	In both HOD patients and CCl4-treated mice, an altered vitamin D metabolism with decreased CYP27A1, CYP2R1, vitamin D-binding protein GC and increased 7-dehydrocholesterol reductase hepatic gene expression, results in decreased 25-OH vitamin D serum levels.	Vitamin D	55-64	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	100-106
25004831-6	2014	Results showed that vitamin D produced a significant reduction in the sera of lipid profile, CRP, and adhesion molecules, associated with a non-significant change in serum calcium and a significant increase in the body level of vitamin D3.	Vitamin D	20-29	C-reactive protein	Oryctolagus cuniculus	93-96
24760528-0	2014	Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-beta expression in the lungs of female BALB/c mice.	Vitamin D	0-9	transforming growth factor, beta 1	Mus musculus	105-113
24760528-10	2014	Both vitamin D-deficient male and female mice had reduced TGF-beta levels in BALF.	Vitamin D	5-14	transforming growth factor, beta 1	Mus musculus	58-66
24760528-11	2014	Vitamin D deficiency did not have an effect on ASM density in E17.5 mice, however, expression of TGF-beta1 and TGF-beta receptor I was downregulated in vitamin D-deficient female fetal mice.	Vitamin D	152-161	transforming growth factor, beta 1	Mus musculus	97-106
24760528-11	2014	Vitamin D deficiency did not have an effect on ASM density in E17.5 mice, however, expression of TGF-beta1 and TGF-beta receptor I was downregulated in vitamin D-deficient female fetal mice.	Vitamin D	152-161	transforming growth factor, beta 1	Mus musculus	97-105
24760528-12	2014	Decreased expression of TGF-beta1 and TGF-beta receptor I during early lung development in vitamin D-deficient mice may contribute to airway remodeling and AHR in vitamin D-deficient adult female mice.	Vitamin D	91-100	transforming growth factor, beta 1	Mus musculus	24-33
24760528-12	2014	Decreased expression of TGF-beta1 and TGF-beta receptor I during early lung development in vitamin D-deficient mice may contribute to airway remodeling and AHR in vitamin D-deficient adult female mice.	Vitamin D	91-100	transforming growth factor, beta 1	Mus musculus	24-32
25911112-0	2015	Vitamin D-binding protein is required for the protective effects of vitamin D in renal fibroblasts and is phosphorylated in diabetic rats.	Vitamin D	68-77	GC, vitamin D binding protein	Rattus norvegicus	0-25
25911112-1	2015	Serum vitamin D is bound to vitamin D-binding protein (DBP).	Vitamin D	6-15	GC, vitamin D binding protein	Rattus norvegicus	28-53
24760528-12	2014	Decreased expression of TGF-beta1 and TGF-beta receptor I during early lung development in vitamin D-deficient mice may contribute to airway remodeling and AHR in vitamin D-deficient adult female mice.	Vitamin D	163-172	transforming growth factor, beta 1	Mus musculus	24-33
25911112-10	2015	Moreover, DBP is required for vitamin D-induced attenuation of HG-induced renin in NRK-49F cells.	Vitamin D	30-39	renin	Rattus norvegicus	74-79
24760528-12	2014	Decreased expression of TGF-beta1 and TGF-beta receptor I during early lung development in vitamin D-deficient mice may contribute to airway remodeling and AHR in vitamin D-deficient adult female mice.	Vitamin D	163-172	transforming growth factor, beta 1	Mus musculus	24-32
24594696-1	2014	OBJECTIVES: Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD).	Vitamin D	12-21	COPD	Homo sapiens	101-105
26037400-0	2015	Vitamin D levels in multiple sclerosis patients: Association with TGF-beta2, TGF-betaRI, and TGF-betaRII expression.	Vitamin D	0-9	transforming growth factor beta receptor 2	Homo sapiens	93-104
24594696-2	2014	Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity.	Vitamin D	8-17	COPD	Homo sapiens	63-67
24203351-0	2015	Is there any association between thrombosis and tissue factor pathway inhibitor levels in patients with vitamin D deficiency?	Vitamin D	104-113	tissue factor pathway inhibitor	Homo sapiens	48-79
24203351-1	2015	OBJECTIVE: The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI).	Vitamin D	74-83	tissue factor pathway inhibitor	Homo sapiens	119-150
24203351-1	2015	OBJECTIVE: The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI).	Vitamin D	74-83	tissue factor pathway inhibitor	Homo sapiens	152-156
24203351-9	2015	CONCLUSION: Further studies are needed for evaluation of the role of TFPI in hemostasis and thrombotic process in patients with vitamin D deficiency.	Vitamin D	128-137	tissue factor pathway inhibitor	Homo sapiens	69-73
24594696-3	2014	We investigated the association between vitamin D status and prevalent and incident COPD in the general population.	Vitamin D	40-49	COPD	Homo sapiens	84-88
26132203-12	2015	It is speculated that the relationship of sunlight exposure with MS might be due to vitamin D availability, and is deserving of further study.	Vitamin D	84-93	MS	Homo sapiens	65-67
24594696-7	2014	We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders.	Vitamin D	65-74	COPD	Homo sapiens	96-100
24594696-8	2014	CONCLUSIONS: We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.	Vitamin D	94-103	COPD	Homo sapiens	115-119
24410734-0	2014	Decreased vitamin D levels in children with familial Mediterranean fever.	Vitamin D	10-19	MEFV innate immuity regulator, pyrin	Homo sapiens	44-72
25833209-7	2015	Compared to the full population, those with vitamin D levels were more likely to be white, PS 1 or 2, to have undergone mastectomy, and to have an ER + tumor.	Vitamin D	44-53	taste 2 receptor member 62 pseudogene	Homo sapiens	91-100
24410734-1	2014	OBJECTIVES: To determine the frequency of vitamin D deficiency in children with familial Mediterranean fever (FMF) and to investigate the factors associated with low vitamin D status.	Vitamin D	42-51	MEFV innate immuity regulator, pyrin	Homo sapiens	80-108
24410734-1	2014	OBJECTIVES: To determine the frequency of vitamin D deficiency in children with familial Mediterranean fever (FMF) and to investigate the factors associated with low vitamin D status.	Vitamin D	42-51	MEFV innate immuity regulator, pyrin	Homo sapiens	110-113
24269661-2	2014	Vitamin D compounds also modulate the response to estradiol-17beta (E2) and the expression mRNAs of estrogen receptors (ERalpha and ERbeta), VDR, 25-hydroxy vitamin D3 1-alpha hydroxylase (1OHase) and lipoxygenases (12LO and 15LO).	Vitamin D	0-9	estrogen receptor 2	Homo sapiens	132-138
25326845-0	2015	Vitamin D prevents the intestinal fibrosis via induction of vitamin D receptor and inhibition of transforming growth factor-beta1/Smad3 pathway.	Vitamin D	0-9	SMAD family member 3	Mus musculus	130-135
24355624-8	2014	CONCLUSIONS: Since both models program for obesity and increased bone mass, and leptin increases plasma vitamin D levels, probably leptin is the link between obesity and higher bone mass.	Vitamin D	104-113	leptin	Rattus norvegicus	80-86
25326845-9	2015	RESULTS: Vitamin D significantly reduced the histological scoring, ECM and collagen productions in the colons and decreased the levels of TGF-beta1, Smad-3, p-Smad3 and Collagen I in SEMF.	Vitamin D	9-18	transforming growth factor, beta 1	Mus musculus	138-147
25326845-9	2015	RESULTS: Vitamin D significantly reduced the histological scoring, ECM and collagen productions in the colons and decreased the levels of TGF-beta1, Smad-3, p-Smad3 and Collagen I in SEMF.	Vitamin D	9-18	SMAD family member 3	Mus musculus	149-155
25326845-9	2015	RESULTS: Vitamin D significantly reduced the histological scoring, ECM and collagen productions in the colons and decreased the levels of TGF-beta1, Smad-3, p-Smad3 and Collagen I in SEMF.	Vitamin D	9-18	SMAD family member 3	Mus musculus	159-164
25326845-12	2015	CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction.	Vitamin D	13-22	transforming growth factor, beta 1	Mus musculus	181-190
25326845-12	2015	CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction.	Vitamin D	13-22	SMAD family member 3	Mus musculus	191-196
25326845-12	2015	CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction.	Vitamin D	77-86	transforming growth factor, beta 1	Mus musculus	181-190
25326845-12	2015	CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction.	Vitamin D	77-86	SMAD family member 3	Mus musculus	191-196
24355624-8	2014	CONCLUSIONS: Since both models program for obesity and increased bone mass, and leptin increases plasma vitamin D levels, probably leptin is the link between obesity and higher bone mass.	Vitamin D	104-113	leptin	Rattus norvegicus	131-137
25448743-0	2015	CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds.	Vitamin D	60-69	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	0-7
24326417-11	2014	Vitamin D deficiency in BN rats correlates with maternal renal CYP24a1 upregulation followed by CYP27b1 upregulation.	Vitamin D	0-9	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	63-70
25500070-9	2015	Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect.	Vitamin D	146-155	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	97-103
25541438-0	2015	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.	Vitamin D	57-66	hes family bHLH transcription factor 1	Homo sapiens	0-4
25541438-11	2015	In conclusion, the Gemini vitamin D analog, BXL0124, represses the tumor-initiating subpopulation by HES1-mediated inhibition of Notch1 signaling.	Vitamin D	26-35	hes family bHLH transcription factor 1	Homo sapiens	101-105
25597951-9	2015	Consistent with this, vitamin D-induced expression of transient receptor potential cation channel, subfamily V, member 6 mRNA was reduced in the colon of CAC; APC(Delta580/Delta580) mice.	Vitamin D	22-31	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	54-120
24334408-0	2014	Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes.	Vitamin D	0-9	dentin matrix protein 1	Mus musculus	20-43
25597952-5	2015	Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%).	Vitamin D	63-72	mutS homolog 2	Homo sapiens	175-179
25294851-9	2015	CONCLUSION: In SHPT, correction of vitamin D and calcitriol deficiency induces parathyroid C/EBPbeta to efficaciously attenuate the severe ADAM17/TGFalpha synergy, which drives PTG enlargement and high PTH.	Vitamin D	35-44	CCAAT enhancer binding protein beta	Homo sapiens	91-100
25294851-9	2015	CONCLUSION: In SHPT, correction of vitamin D and calcitriol deficiency induces parathyroid C/EBPbeta to efficaciously attenuate the severe ADAM17/TGFalpha synergy, which drives PTG enlargement and high PTH.	Vitamin D	35-44	transforming growth factor alpha	Homo sapiens	146-154
25737638-0	2015	Effect of vitamin D therapy on interleukin-6, visfatin, and hyaluronic acid levels in chronic hepatitis C Egyptian patients.	Vitamin D	10-19	nicotinamide phosphoribosyltransferase	Homo sapiens	46-54
25510482-0	2015	Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells.	Vitamin D	39-48	forkhead box P3	Homo sapiens	141-146
25510482-6	2015	Altogether, vitamin D-deficient TB patients expressed a weak antimicrobial response but an IL-21 associated expansion of IgG-secreting B cells combined with a rise in FoxP3(+) regulatory T cells at the local site of infection.	Vitamin D	12-21	forkhead box P3	Homo sapiens	167-172
25486937-7	2014	Our group has synthesized a novel vitamin D analogue (EM1) bearing an alkynylphosphonate moiety that combines the low calcemic properties of phosphonates with the decreased metabolic inactivation due to the presence of a triple bond between C-23 and C-24.	Vitamin D	34-43	nucleolin	Homo sapiens	241-245
25530010-11	2015	The findings obtained indicate that increased vitamin D and calcium intakes are effective in increasing mineral (Ca and P) content in the growing bone of obese mice and that the hormonal mechanism of this effect may involve the vitamin D-PTH axis.	Vitamin D	46-55	parathyroid hormone	Mus musculus	238-241
25530010-11	2015	The findings obtained indicate that increased vitamin D and calcium intakes are effective in increasing mineral (Ca and P) content in the growing bone of obese mice and that the hormonal mechanism of this effect may involve the vitamin D-PTH axis.	Vitamin D	228-237	parathyroid hormone	Mus musculus	238-241
25548714-0	2014	Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D 2 (300,000 IU).	Vitamin D	72-81	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	11-21
25396269-8	2015	Our data indicate that out of the variants in 29 different genes analyzed, variants of 11 genes, including EXOC2, TYR, and TYRP1, have the highest impact on vitamin D status.	Vitamin D	157-166	exocyst complex component 2	Homo sapiens	107-112
24135500-8	2014	If vitamin D and its metabolites are implicated in endometriosis-associated infertility, it is likely through interference with HOXA10 gene expression.	Vitamin D	3-12	homeobox A10	Homo sapiens	128-134
25737686-9	2014	Cox"s regression analysis showed that active vitamin D treatment was associated with a significantly lower risk of all-cause mortality (RR = 0.399, 95% CI 0.185-0.862, p = 0.019) and cardiovascular mortality (RR = 0.295, 95% CI 0.094-0.93, p = 0.037).	Vitamin D	45-54	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
25061262-3	2014	We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways.	Vitamin D	28-37	interleukin 33	Homo sapiens	75-80
25366113-0	2014	Multiple sclerosis: effects of IFN-beta treatment on vitamin D levels in multiple sclerosis are modified by genetic variants.	Vitamin D	53-62	interferon beta 1	Homo sapiens	31-39
24404569-8	2013	RESULTS: Multivariable Cox regression analyses with age as underlying time axis and delayed entry showed lower mortality risk with higher vitamin D levels and this was essentially unaffected by adjustment for liver enzyme levels with hazard ratio, 0.96 (95% confidence interval, 0.93e0.99) for a 10 nmol/L higher vitamin D level.	Vitamin D	138-147	cytochrome c oxidase subunit 8A	Homo sapiens	23-26
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	nuclear receptor corepressor 2	Homo sapiens	216-221
23954214-3	2013	We studied the effect of vitamin D supplementation in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of MS, at three different developmental stages in rats.	Vitamin D	25-34	myelin oligodendrocyte glycoprotein	Rattus norvegicus	54-89
24788893-1	2014	Vitamin D analogues can reduce TGF-beta pro-fibrotic signaling in dermal fibroblasts, but they may also induce a potentially pro-fibrotic thymic stromal lymphopoietin (TSLP)-dependent Th2 cytokine local response.	Vitamin D	0-9	thymic stromal lymphopoietin	Mus musculus	168-172
24673126-3	2014	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], has been shown to increase the frequency of Foxp3(+) CD4(+) T regulatory (Treg) cells when present at high concentrations or under strong T-cell stimulation in culture.	Vitamin D	19-28	forkhead box P3	Homo sapiens	119-124
23954214-3	2013	We studied the effect of vitamin D supplementation in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of MS, at three different developmental stages in rats.	Vitamin D	25-34	myelin oligodendrocyte glycoprotein	Rattus norvegicus	91-94
24630484-2	2014	To investigate the effect of vitamin D derivatives on adhesion molecules and MMPs in colonic biopsies of IBD patients.	Vitamin D	29-38	matrix metallopeptidase 2	Homo sapiens	77-81
23665342-2	2013	Both vitamin D and melatonin are essential mediators of the effect of sunlight in health, and as such are candidates to play a key role in MS. We hypothesized that vitamin D and melatonin may have related influences in patients with MS. METHODS: In a randomized, double blind study of 40 IFN-beta treated MS patients, 21 patients were assigned to 800 IU of vitamin D3 per day (low dose), while 19 patients received 4,370 IU vitamin D3 per day (high dose) for one year.	Vitamin D	164-173	interferon beta 1	Homo sapiens	288-296
24630484-7	2014	The expression of MMP-9, MMP-2, and MMP-3 decreases in the presence of vitamin D derivatives in UC and CD with the exception of 1,25(OH)2D3 that does not affect the levels of MMP-9 and MMP-2 in CD.	Vitamin D	71-80	matrix metallopeptidase 2	Homo sapiens	25-30
24630484-8	2014	Vitamin D derivatives always affect MMP-9, MMP-2 and ICAM-1 in PBMC of UC and CD patients.	Vitamin D	0-9	matrix metallopeptidase 2	Homo sapiens	43-48
24630484-9	2014	CONCLUSIONS: Based on the increased expression of ICAM-1, MAdCAM-1 and MMP-2,-9,-3 in IBD, our study suggests that vitamin D derivatives may be effective in the management of these diseases.	Vitamin D	115-124	matrix metallopeptidase 2	Homo sapiens	71-76
25016144-5	2014	When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis.	Vitamin D	106-115	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	46-49
23736055-0	2013	A genomewide association study identified CYP2J2 as a gene controlling serum vitamin D status in beef cattle.	Vitamin D	77-86	cytochrome P450 2J2	Bos taurus	42-48
25016144-6	2014	This preliminary study suggests the use of vitamin D as prophylaxis for tuberculosis in high DM2 endemic countries.	Vitamin D	43-52	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	93-96
23736055-15	2013	CYP2J2 should be considered a prime candidate for understanding both genetic and physiological factors affecting serum 25OHD concentrations in cattle and, therefore, vitamin D status.	Vitamin D	166-175	cytochrome P450 2J2	Bos taurus	0-6
24719373-0	2014	Does low vitamin D amplify the association of COPD with total and cardiovascular disease mortality?	Vitamin D	9-18	COPD	Homo sapiens	46-50
24719373-1	2014	BACKGROUND: Chronic obstructive pulmonary disease (COPD) has been shown to be associated with lower levels of vitamin D, and the latter has been associated with total and cardiovascular disease (CVD) mortality.	Vitamin D	110-119	COPD	Homo sapiens	51-55
23250517-3	2013	The goal of this study is to show the presence of 25 hydroxy vitamin D3-24 hydroxylase (24OHase) which is essential for vitamin D catabolism in hippocampal and cortical neurons.	Vitamin D	61-70	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	88-95
24719373-2	2014	HYPOTHESIS: We hypothesized that lower vitamin D levels will further enhance the association of COPD and its severity with total and CVD mortality.	Vitamin D	39-48	COPD	Homo sapiens	96-100
24719373-7	2014	RESULTS: From Cox regression, unadjusted HRs increased successively with increasing COPD severity and decreasing vitamin D group to 4.5 (95% CI: 3.3-6.1) for total and 3.4 (95% CI: 2.2-5.3) for CVD mortality among those with moderate/severe COPD who were in the first tertile of vitamin D.	Vitamin D	113-122	COPD	Homo sapiens	241-245
24719373-7	2014	RESULTS: From Cox regression, unadjusted HRs increased successively with increasing COPD severity and decreasing vitamin D group to 4.5 (95% CI: 3.3-6.1) for total and 3.4 (95% CI: 2.2-5.3) for CVD mortality among those with moderate/severe COPD who were in the first tertile of vitamin D.	Vitamin D	279-288	COPD	Homo sapiens	84-88
24719373-9	2014	CONCLUSIONS: Lower levels of vitamin D may be associated with further increases in total and CVD mortality associated with COPD; however, age and cardiovascular risk factors appear to explain much of this association.	Vitamin D	29-38	COPD	Homo sapiens	123-127
23250517-12	2013	Higher gene expression of 24OHase and VDR might indicate "higher requirement of vitamin D" in hippocampus and potential consequences of vitamin D deficiency in cognitive decline, neurodegeneration, and Alzheimer"s disease.	Vitamin D	80-89	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	26-33
23250517-12	2013	Higher gene expression of 24OHase and VDR might indicate "higher requirement of vitamin D" in hippocampus and potential consequences of vitamin D deficiency in cognitive decline, neurodegeneration, and Alzheimer"s disease.	Vitamin D	136-145	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	26-33
23669253-11	2013	Vitamin D-treated rats showed a significant decrease in plasma CK level, phosphorylation of AMPK, p38, ERK1/2, IKK, and IkappaB, and gene expression of IL-6 and TNF-alpha.	Vitamin D	0-9	mitogen activated protein kinase 14	Rattus norvegicus	98-101
25048368-0	2014	Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.	Vitamin D	0-9	renin	Rattus norvegicus	128-133
25048368-2	2014	Vitamin D has been associated with renal and cardiovascular diseases because of its effects on oxidative stress, lipid metabolism and renin-angiotensin-aldosterone system (RAAS).	Vitamin D	0-9	renin	Rattus norvegicus	134-139
23669253-11	2013	Vitamin D-treated rats showed a significant decrease in plasma CK level, phosphorylation of AMPK, p38, ERK1/2, IKK, and IkappaB, and gene expression of IL-6 and TNF-alpha.	Vitamin D	0-9	mitogen activated protein kinase 3	Rattus norvegicus	103-109
24726754-5	2014	We measured levels of tumor necrosis factor (TNF)alpha in liver tissues from patients with PSC and the effects of exposure to active vitamin D (1,25[OH]2D3) on expression of CD28.	Vitamin D	133-142	CD28 molecule	Homo sapiens	174-178
23767916-0	2013	Vitamin D supplementation for patients with multiple sclerosis treated with interferon-beta: a randomized controlled trial assessing the effect on flu-like symptoms and immunomodulatory properties.	Vitamin D	0-9	interferon beta 1	Homo sapiens	76-91
24939880-4	2014	Microarray analysis of rat ICC tissues showed vitamin D supplementation modulated the expressions of several unique genes, including lipocalin 2 (Lcn2), confirmed by RT-qPCR and immunohistochemical (IHC) staining.	Vitamin D	46-55	lipocalin 2	Rattus norvegicus	133-144
24939880-4	2014	Microarray analysis of rat ICC tissues showed vitamin D supplementation modulated the expressions of several unique genes, including lipocalin 2 (Lcn2), confirmed by RT-qPCR and immunohistochemical (IHC) staining.	Vitamin D	46-55	lipocalin 2	Rattus norvegicus	146-150
24926881-11	2014	Up-regulation of TLR2, TLR4 and dectin-1was observed in the lungs and AMs from vitamin D deficient mice both at baseline and after A. fumigatus exposure.	Vitamin D	79-88	toll-like receptor 2	Mus musculus	17-21
23767916-12	2013	CONCLUSION: Vitamin D supplementation to IFN-beta treated PwMS, at the doses used, seems safe and associated with dose-dependent changes in IL-17 serum levels, while not affecting IFN-beta related FLS.	Vitamin D	12-21	interferon beta 1	Homo sapiens	41-49
23439304-2	2013	It has been shown that vitamin D deficiency is associated with increased OX40L expression in peripheral CD11c(+) cells and controls Th2 responses to Aspergillus fumigatus in vitro in cystic fibrosis (CF) patients with allergic bronchopulmonary aspergillosis (ABPA).	Vitamin D	23-32	integrin subunit alpha X	Homo sapiens	104-109
24681654-9	2014	The proportion of CD25hi CD4 cells from patients with CD increased in the presence of vitamin D.	Vitamin D	86-95	interleukin 2 receptor subunit alpha	Homo sapiens	18-22
23439304-3	2013	To investigate if vitamin D deficiency regulated OX40L and Th2 responses in vivo, we examined the effect of nutritional vitamin D deficiency on costimulatory molecules in CD11c(+) cells and A. fumigatus-induced Th2 responses.	Vitamin D	120-129	integrin subunit alpha X	Homo sapiens	171-176
24251869-4	2014	RESULTS: Vit D (10 IU/kg/60 days) significantly (p &lt; 0.05) decreased fasting plasma glucose, ketoacidosis (decreased non-esterified fatty acid and beta-hydroxyl butyric acid), pro-inflammatory interleukin-6, HbA1c in T1D and T2D and insulin resistance index by 33% in T2D.	Vitamin D	9-14	hemoglobin alpha, adult chain 1	Rattus norvegicus	211-215
23439304-4	2013	Vitamin D-deficient mice showed increased expression of OX40L on lung CD11c(+) cells, and OX40L was critical for enhanced Th2 responses to A. fumigatus in vivo.	Vitamin D	0-9	tumor necrosis factor (ligand) superfamily, member 4	Mus musculus	56-61
23439304-4	2013	Vitamin D-deficient mice showed increased expression of OX40L on lung CD11c(+) cells, and OX40L was critical for enhanced Th2 responses to A. fumigatus in vivo.	Vitamin D	0-9	integrin subunit alpha X	Homo sapiens	70-75
23436065-9	2013	The combination of vitamin A and vitamin D markedly enhanced the expression of Bax and reduced the expression of Cyclin D1 by real time-PCR and western blot assay.	Vitamin D	33-42	cyclin D1	Homo sapiens	113-122
24862751-10	2014	The four-month lag for attaining vitamin D sufficiency in 90% of infants in the SDR group may have clinical implications and should be further investigated.	Vitamin D	33-42	caveolae associated protein 2	Homo sapiens	80-83
23449998-5	2013	The IFN-gamma-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-beta and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.	Vitamin D	33-42	interferon beta 1	Homo sapiens	101-109
24619416-0	2014	Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4.	Vitamin D	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	19-24
23322908-3	2013	Furthermore, vitamin D supplements appear to have a beneficial clinical effect on AD by regulating micro-RNA, enhancing toll-like receptors, modulating vascular endothelial factor expression, modulating angiogenin, and advanced glycation end products.	Vitamin D	13-22	angiogenin	Homo sapiens	203-213
24619416-3	2014	We found that the active form of vitamin D, 1,25(OH)2D produces dose-dependent inhibition of COX-2 expression in murine macrophages under both basal and LPS-stimulated conditions and suppresses proinflammatory mediators induced by LPS.	Vitamin D	33-42	cytochrome c oxidase II, mitochondrial	Mus musculus	93-98
24619416-8	2014	Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-kappaB/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease.	Vitamin D	26-35	cytochrome c oxidase II, mitochondrial	Mus musculus	122-127
24619416-8	2014	Our results indicate that vitamin D restrains macrophage-mediated inflammatory processes by suppressing the Akt/NF-kappaB/COX-2 pathway, suggesting that vitamin D supplementation might be utilized for adjunctive therapy for inflammatory disease.	Vitamin D	153-162	cytochrome c oxidase II, mitochondrial	Mus musculus	122-127
23021843-2	2013	Different approaches to the determination of vitamin D using affinity based biosensors, are described herein; firstly, an immunosensor based on SPR transduction was realized for direct determination of vitamin D, obtaining a LOD of 2 mug/ml which unfortunately is too far from the needs in clinical analysis.	Vitamin D	45-54	sepiapterin reductase	Homo sapiens	144-147
24146318-1	2014	BACKGROUND: In order for vitamin D to signal and regulate inflammatory pathways, it must bind to its receptor (VDR) which must heterodimerize with the retinoid X receptor alpha (RXRalpha).	Vitamin D	25-34	retinoid X receptor alpha	Mus musculus	151-176
24146318-1	2014	BACKGROUND: In order for vitamin D to signal and regulate inflammatory pathways, it must bind to its receptor (VDR) which must heterodimerize with the retinoid X receptor alpha (RXRalpha).	Vitamin D	25-34	retinoid X receptor alpha	Mus musculus	178-186
23021843-2	2013	Different approaches to the determination of vitamin D using affinity based biosensors, are described herein; firstly, an immunosensor based on SPR transduction was realized for direct determination of vitamin D, obtaining a LOD of 2 mug/ml which unfortunately is too far from the needs in clinical analysis.	Vitamin D	202-211	sepiapterin reductase	Homo sapiens	144-147
23021843-3	2013	In order to enhance the sensitivity, the vitamin D was modified with gold nanoparticles (AuNPs): the binding of 25OHD with AuNPs determines the amplification of SPR signal, allowing to lower the LOD down to 1 mug/ml, doubling the sensitivity.	Vitamin D	41-50	sepiapterin reductase	Homo sapiens	161-164
23868949-0	2014	Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis.	Vitamin D	79-88	protein kinase C beta	Homo sapiens	28-31
23021843-4	2013	An alternative SPR method, based on the indirect determination of vitamin D by means of Vitamin D Binding Protein (VDBP), led to a further sensitivity increase reaching a LOD of 45 ng/ml which is really close to the fixed accomplishment.	Vitamin D	66-75	sepiapterin reductase	Homo sapiens	15-18
24494048-8	2013	The fact that UV-induced vitamin D may reduce the risk of CMM complicates the discussion.	Vitamin D	25-34	dysplastic nevus syndrome	Homo sapiens	58-61
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Vitamin D	194-203	fibroblast growth factor 21	Mus musculus	91-96
22683512-7	2013	It also explores how CAF concentration is influenced by vitamin D supplementation and physical exercise.	Vitamin D	56-65	lysine acetyltransferase 2B	Homo sapiens	21-24
24180595-8	2014	Whereas the levels of Der p 1-induced IL-10 and TGF-beta were similar between IT groups, the mean fluorescence intensity of Foxp3 was highest in the SCIT + vitamin D group compared with others at the 12th month.	Vitamin D	156-165	forkhead box P3	Homo sapiens	124-129
24326417-5	2014	BN rats had a pregnancy-dependent upregulation of CYP24a1 expression, a key enzyme that inactivates vitamin D metabolites.	Vitamin D	100-109	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	50-57
22683512-15	2013	Vitamin D supplementation and physical exercise were significantly associated with a reduction in CAF concentration, especially in participants with initially high CAF concentrations.	Vitamin D	0-9	lysine acetyltransferase 2B	Homo sapiens	98-101
24468256-8	2014	Transcription factors PU.1 and interferon regulatory factor 4 were downregulated by vitamin D but not GATA3 and c-MAF.	Vitamin D	84-93	interferon regulatory factor 4	Homo sapiens	31-61
22683512-15	2013	Vitamin D supplementation and physical exercise were significantly associated with a reduction in CAF concentration, especially in participants with initially high CAF concentrations.	Vitamin D	0-9	lysine acetyltransferase 2B	Homo sapiens	164-167
24468256-9	2014	When PBMCs from patients with positive radioallergosorbent test results were stimulated with dust mite allergen, vitamin D decreased IL-9, IL-5, and IL-13 in T-helper cells (CD4(+)).	Vitamin D	113-122	interleukin 9	Homo sapiens	133-137
24468256-9	2014	When PBMCs from patients with positive radioallergosorbent test results were stimulated with dust mite allergen, vitamin D decreased IL-9, IL-5, and IL-13 in T-helper cells (CD4(+)).	Vitamin D	113-122	interleukin 5	Homo sapiens	139-143
22683512-18	2013	CAF concentration is reduced by vitamin D supplementation and physical exercise and therefore suggests a potentially positive effect on NMJs.	Vitamin D	32-41	lysine acetyltransferase 2B	Homo sapiens	0-3
23451204-1	2013	The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism.	Vitamin D	209-218	fibroblast growth factor 23	Rattus norvegicus	25-52
25171473-1	2014	BACKGROUND AND OBJECTIVE: Deficiency of vitamin D could be a major cause of colon cancer as suggested as early as 1980 by Drs.	Vitamin D	40-49	sushi repeat containing protein X-linked	Homo sapiens	122-125
23451204-1	2013	The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism.	Vitamin D	209-218	fibroblast growth factor 23	Rattus norvegicus	54-59
22926646-4	2012	Although the renoprotective mechanism of active vitamin D in previous studies has been mainly attributed to the suppression of renin, OCT did not affect renal levels of renin or angiotensin II.	Vitamin D	48-57	renin	Rattus norvegicus	127-132
23112173-2	2012	Vitamin D signaling can suppress expression of genes regulated by c-MYC, a transcription factor that controls epidermal differentiation and cell proliferation and whose activity is frequently elevated in cancer.	Vitamin D	0-9	myelocytomatosis oncogene	Mus musculus	68-71
23112173-10	2012	Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D.	Vitamin D	145-154	myelocytomatosis oncogene	Mus musculus	39-42
23112173-10	2012	Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D.	Vitamin D	145-154	myelocytomatosis oncogene	Mus musculus	70-73
22932684-8	2012	Vitamin D(3) induced pro-MMP-2 activity (1.29 +- 0.17) and VEGF mRNA levels (1.74 +- 0.73) in ECFCs.	Vitamin D	0-9	matrix metallopeptidase 2	Homo sapiens	25-30
22932684-11	2012	Consequently, vitamin D(3) significantly promoted angiogenesis in ECFCs in vitro possibly due to an increase in VEGF expression and pro-MMP-2 activity.	Vitamin D	14-23	matrix metallopeptidase 2	Homo sapiens	136-141
22930691-1	2012	Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalacia.	Vitamin D	256-265	dentin matrix protein 1	Mus musculus	0-23
22930691-1	2012	Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalacia.	Vitamin D	256-265	dentin matrix protein 1	Mus musculus	25-29
22589201-1	2012	Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an apical membrane calcium (Ca) channel in the small intestine proposed to be essential for vitamin D-regulated intestinal Ca absorption.	Vitamin D	170-179	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	0-66
22589201-1	2012	Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an apical membrane calcium (Ca) channel in the small intestine proposed to be essential for vitamin D-regulated intestinal Ca absorption.	Vitamin D	170-179	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	68-73
22827382-9	2012	Associated with the decrease in AMH expression by vitamin D, follicle-stimulating hormone receptor mRNA is increased.	Vitamin D	50-59	anti-Mullerian hormone	Gallus gallus	32-35
22954915-1	2012	OBJECTIVE: To survey the prevalence of vitamin D deficiency in patients with chronic obstructive pulmonary disease (COPD) and to determine the impact of vitamin D deficiency on the quality of life in COPD patients.	Vitamin D	39-48	COPD	Homo sapiens	116-120
22954915-9	2012	2) The prevalence of vitamin D deficiency was 52.78% in the AECOPD group and that was 39.47% in the stable COPD group.	Vitamin D	21-30	COPD	Homo sapiens	62-66
22954915-10	2012	The total prevalence of vitamin D deficiency was 45.95% in COPD patients.	Vitamin D	24-33	COPD	Homo sapiens	59-63
22954915-13	2012	3) The prevalence of vitamin D deficiency in the AECOPD group was significantly higher than that in the control group (P&lt;0.01) and the prevalence of vitamin D deficiency in the stable COPD group was significantly higher than that in the control group (P&lt;0.05).	Vitamin D	21-30	COPD	Homo sapiens	51-55
22954915-17	2012	CONCLUSION: Vitamin D deficiency is highly prevalent in COPD patients.	Vitamin D	12-21	COPD	Homo sapiens	56-60
22954915-18	2012	Vitamin D deficiency may have negative impact on the life quality in COPD patients.	Vitamin D	0-9	COPD	Homo sapiens	69-73
23467804-11	2012	Future studies will clarify the effect of vitamin D compounds on expression and function of potential key regulators of skin aging, such as TAp63 or the IGF-1 signaling pathway.	Vitamin D	42-51	insulin-like growth factor 1	Mus musculus	153-158
22728934-4	2012	Neutralization of FGF23 led to sustained reductions in secondary HPT, including decreased parathyroid hormone, increased vitamin D, increased serum calcium, and normalization of bone markers such as cancellous bone volume, trabecular number, osteoblast surface, osteoid surface, and bone-formation rate.	Vitamin D	121-130	fibroblast growth factor 23	Rattus norvegicus	18-23
22474172-4	2012	We show here that treatment of human intestine-derived Caco-2 cells with vitamin D(3) markedly increased endogenous OATP1A2 mRNA and protein levels.	Vitamin D	73-82	solute carrier organic anion transporter family member 1A2	Homo sapiens	116-123
22474172-11	2012	We showed that expression of the SLCO1A2 gene is induced by vitamin D(3) at the transcriptional level through the VDR.	Vitamin D	60-69	solute carrier organic anion transporter family member 1A2	Homo sapiens	33-40
22474172-12	2012	Our results suggest that pharmacological administration of vitamin D(3) may allow modulation of intestinal absorption of OATP1A2 transport substrates.	Vitamin D	59-68	solute carrier organic anion transporter family member 1A2	Homo sapiens	121-128
22529297-0	2012	1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region.	Vitamin D	13-22	forkhead box P3	Homo sapiens	33-38
22301548-8	2012	Moreover, in BMM from MKP1(-/-) mice, the inhibition of LPS-induced p38 phosphorylation by vitamin D was completely abolished.	Vitamin D	91-100	mitogen-activated protein kinase 14	Mus musculus	68-71
22250148-0	2012	Severe vitamin D deficiency: a prerequisite for COPD responsiveness to vitamin D supplementation?	Vitamin D	7-16	COPD	Homo sapiens	48-52
22300961-10	2012	Analysing combined effects, a significant impact of low 25-OH vitamin D levels on sustained virological response were only seen in patients with the unfavourable NR1I1 CCA (bAt) haplotype (OR for non-SVR 3.55; 95% CI 1.005, 12.57; P=0.049).	Vitamin D	62-71	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	173-176
22212905-1	2011	Astrogorgiadiol is a naturally occurring Vitamin D analogue that, in cell culture, downregulates the production of the cytokine osteopontin (OPN).	Vitamin D	41-50	secreted phosphoprotein 1	Mus musculus	128-139
22212905-1	2011	Astrogorgiadiol is a naturally occurring Vitamin D analogue that, in cell culture, downregulates the production of the cytokine osteopontin (OPN).	Vitamin D	41-50	secreted phosphoprotein 1	Mus musculus	141-144
21615392-12	2011	Ethnic background, sex, age, body weight and SNPs in CYP24A1 and PLCB1 were independent determinants of plasma vitamin D levels.	Vitamin D	111-120	phospholipase C beta 1	Homo sapiens	65-70
24192346-5	2014	Additionally, neprilysin (NEP) expression is downregulated resulting in a decreased NEP activity further enhancing the effect of decreased vitamin D on the Abeta level.	Vitamin D	139-148	membrane metallo endopeptidase	Mus musculus	14-24
24192346-5	2014	Additionally, neprilysin (NEP) expression is downregulated resulting in a decreased NEP activity further enhancing the effect of decreased vitamin D on the Abeta level.	Vitamin D	139-148	membrane metallo endopeptidase	Mus musculus	26-29
24192346-5	2014	Additionally, neprilysin (NEP) expression is downregulated resulting in a decreased NEP activity further enhancing the effect of decreased vitamin D on the Abeta level.	Vitamin D	139-148	membrane metallo endopeptidase	Mus musculus	84-87
22014969-10	2011	In multivariable analyses adjusting for age and race norms, vitamin D deficiency was associated with the presence of moderate-severe UI (POR 1.8, 95% CI 1.1, 3.0) and at least 1 LUTS (POR 1.4, 95% CI 1.0, 2.0).	Vitamin D	60-69	ADP ribosylation factor interacting protein 2	Homo sapiens	137-142
23674177-9	2013	Multiple regression analysis showed that among BPPV subjects, there was positive correlation between P1NP and sNTX and a negative correlation between P1NP and vitamin D level.	Vitamin D	159-168	benign paroxysmal positional vertigo	Homo sapiens	47-51
24251203-7	2013	The results indicate a potential antidiabetic function of vitamin D on GLUT1, GLUT4, VDR, and IR by improving receptor gene expression suggesting a role for vitamin D in regulation of expression of the glucose transporters in muscle cells.	Vitamin D	58-67	insulin receptor	Homo sapiens	94-96
22014969-10	2011	In multivariable analyses adjusting for age and race norms, vitamin D deficiency was associated with the presence of moderate-severe UI (POR 1.8, 95% CI 1.1, 3.0) and at least 1 LUTS (POR 1.4, 95% CI 1.0, 2.0).	Vitamin D	60-69	ADP ribosylation factor interacting protein 2	Homo sapiens	184-189
21682758-3	2011	VDR-knockout mice suffer from cardiovascular disease (CVD), and various experimental studies suggest cardiovascular protection by vitamin D, including antiatherosclerotic, anti-inflammatory and direct cardio-protective actions, beneficial effects on classic cardiovascular risk factors as well as suppression of parathyroid hormone (PTH) levels.	Vitamin D	130-139	parathyroid hormone	Mus musculus	312-331
24970730-0	2013	Maternal vitamin D deficiency programmes adult renal renin gene expression and renal function.	Vitamin D	9-18	renin	Rattus norvegicus	53-58
24970730-1	2013	Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression.	Vitamin D	62-71	renin	Rattus norvegicus	0-5
24970730-1	2013	Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression.	Vitamin D	62-71	renin	Rattus norvegicus	93-98
24970730-2	2013	We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained.	Vitamin D	39-48	renin	Rattus norvegicus	84-89
24970730-11	2013	We conclude that maternal vitamin D depletion upregulates fetal renal renin gene expression and this persists into adulthood where, in males only, there is evidence of sodium retention and compromised renal function.	Vitamin D	26-35	renin	Rattus norvegicus	70-75
21398497-8	2011	Surprisingly, other steroid hormones (progesterone, estradiol, and vitamin D; 10(-7) M) significantly increased SP-B mRNA levels, suggesting a common pathway of steroid hormone action on SP-B mRNA stability.	Vitamin D	67-76	surfactant protein B	Homo sapiens	112-116
23733667-4	2013	Because patients with Hb E/beta-thalassemia are so clinically diverse, the prevalence of vitamin D deficiency might differ among Hb E/beta-thalassemia patients.	Vitamin D	89-98	hemoglobin subunit epsilon 1	Homo sapiens	22-26
23733667-4	2013	Because patients with Hb E/beta-thalassemia are so clinically diverse, the prevalence of vitamin D deficiency might differ among Hb E/beta-thalassemia patients.	Vitamin D	89-98	hemoglobin subunit epsilon 1	Homo sapiens	129-133
23733667-9	2013	CONCLUSIONS: Our results highlight the importance of monitoring serum vitamin D levels in children with Hb E/beta-thalassemia regardless of their clinical severity or the amount of sunlight they are exposed to.	Vitamin D	70-79	hemoglobin subunit epsilon 1	Homo sapiens	104-108
21398497-8	2011	Surprisingly, other steroid hormones (progesterone, estradiol, and vitamin D; 10(-7) M) significantly increased SP-B mRNA levels, suggesting a common pathway of steroid hormone action on SP-B mRNA stability.	Vitamin D	67-76	surfactant protein B	Homo sapiens	187-191
21419242-12	2011	However, in vitamin D-treated primary rat osteoblast cells E+RLX increased OPG protein and reduced the RANKL/OPG protein ratio.	Vitamin D	12-21	TNF superfamily member 11	Rattus norvegicus	103-108
23872713-5	2013	Expression levels of the sodium phosphate transporter Npt2a and the vitamin D-metabolizing enzymes Cyp24a1 and Cyp27b1 were modulated in kidneys of animals dosed with the pan-FGFR inhibitor.	Vitamin D	68-77	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	99-106
21595846-0	2011	Role of megalin and cubilin in the metabolism of vitamin D(3).	Vitamin D	49-58	LDL receptor related protein 2	Homo sapiens	8-15
21605467-0	2011	Predominance of Th2 polarization by vitamin D through a STAT6-dependent mechanism.	Vitamin D	36-45	signal transducer and activator of transcription 6	Mus musculus	56-61
24019477-10	2013	Our results support the idea that the CYP2R1 is the major enzyme responsible for 25-hydroxylation of vitamin D, but clearly a second, as-yet unknown, enzyme is another contributor to this important step in vitamin D activation.	Vitamin D	101-110	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	38-44
24019477-10	2013	Our results support the idea that the CYP2R1 is the major enzyme responsible for 25-hydroxylation of vitamin D, but clearly a second, as-yet unknown, enzyme is another contributor to this important step in vitamin D activation.	Vitamin D	206-215	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	38-44
23923049-4	2013	The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues.	Vitamin D	66-75	CD14 molecule	Homo sapiens	10-14
23923049-4	2013	The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues.	Vitamin D	138-147	CD14 molecule	Homo sapiens	10-14
23923049-5	2013	However, in a ranking of the samples concerning their expected response to vitamin D only the top half showed a positive correlation between the changes of CD14 or THBD mRNA and serum 25(OH)D3 concentrations.	Vitamin D	75-84	CD14 molecule	Homo sapiens	156-160
21605467-10	2011	CONCLUSIONS: These results of vitamin D promoting a Th2 shift through upstream GATA-3 and STAT6 transcription factors shed mechanistic understanding on the utility of vitamin D in MS.	Vitamin D	30-39	signal transducer and activator of transcription 6	Mus musculus	90-95
23770363-0	2013	Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.	Vitamin D	0-9	glutathione-disulfide reductase	Homo sapiens	52-73
21605467-10	2011	CONCLUSIONS: These results of vitamin D promoting a Th2 shift through upstream GATA-3 and STAT6 transcription factors shed mechanistic understanding on the utility of vitamin D in MS.	Vitamin D	167-176	signal transducer and activator of transcription 6	Mus musculus	90-95
21280209-7	2011	Transfection of HEK cells with SR-BI, Cluster Determinant 36 and Niemann-Pick C1 Like 1 significantly enhanced vitamin D uptake, which was significantly decreased by the addition of Block Lipid Transport-1, sulfo-N-succinimidyl oleate (Cluster Determinant 36 inhibitor) or ezetimibe glucuronide, respectively.	Vitamin D	111-120	scavenger receptor class B, member 1	Mus musculus	31-36
23426901-0	2013	Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget"s disease.	Vitamin D	39-48	activating transcription factor 7	Homo sapiens	8-12
21463608-7	2011	While all three doses of BMP-2 acted similarly in reinforcing the effect of vitamin D(3), vitamin D(3) dose-dependently augmented the osteogenic effect of BMP-2.	Vitamin D	76-85	bone morphogenetic protein 2	Homo sapiens	25-30
23179257-11	2013	Vitamin D deficiency was found in 11.1, 22.2 and 55.6 % of Gr1, 2 and 3.	Vitamin D	0-9	semaphorin 4D	Homo sapiens	59-71
23436936-5	2013	Deletion of miR-155 attenuates vitamin D suppression of LPS-induced inflammation, confirming that 1,25(OH)2D3 stimulates suppressor of cytokine signaling 1 by downregulating miR-155.	Vitamin D	31-40	microRNA 155	Mus musculus	12-19
21463608-7	2011	While all three doses of BMP-2 acted similarly in reinforcing the effect of vitamin D(3), vitamin D(3) dose-dependently augmented the osteogenic effect of BMP-2.	Vitamin D	90-99	bone morphogenetic protein 2	Homo sapiens	155-160
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	gap junction protein alpha 1	Homo sapiens	190-201
21463608-8	2011	When BMP-2 was constantly treated, vitamin D(3) effect did not differ depending on the period of vitamin D(3) treatment.	Vitamin D	35-44	bone morphogenetic protein 2	Homo sapiens	5-10
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	toll like receptor 10	Homo sapiens	291-297
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	gap junction protein alpha 1	Homo sapiens	56-67
23012315-7	2013	Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta.	Vitamin D	29-38	gap junction protein alpha 1	Homo sapiens	67-78
23012315-7	2013	Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta.	Vitamin D	29-38	gap junction protein alpha 1	Homo sapiens	116-127
21289245-3	2011	OBJECTIVE: To examine the effect of 1,25-dihydroxyvitamin D(3) (vitamin D(3)) on TGF-beta3-induced fibrosis-related protein expression in immortalized human uterine leiomyoma (HuLM) cells.	Vitamin D	50-59	transforming growth factor beta 3	Homo sapiens	81-90
21289245-6	2011	Western blots as well as immunofluorescence analyses were used to verify the effect of vitamin D(3) on TGF-beta3-induced Smad activation involved in extracellular matrix protein synthesis and deposition, which ultimately lead to tissue fibrosis.	Vitamin D	87-96	transforming growth factor beta 3	Homo sapiens	103-112
21289245-7	2011	RESULTS: We observed that TGF-beta3 induced fibronectin and collagen type 1 protein expression in HuLM cells, and that effect was suppressed by vitamin D(3).	Vitamin D	144-153	transforming growth factor beta 3	Homo sapiens	26-35
23650781-10	2013	Responders to ribavirin plus pegylated interferon alpha 2a therapy had significantly higher vitamin D levels than non-responders.	Vitamin D	92-101	interferon alpha 2	Homo sapiens	39-58
21289245-8	2011	TGF-beta3 also induced protein expression of plasminogen activator inhibitor-1, an important TGF-beta target, in HuLM cells, which was also inhibited by vitamin D(3).	Vitamin D	153-162	transforming growth factor beta 3	Homo sapiens	0-9
21289245-9	2011	Additionally, TGF-beta3 induced phosphorylation of Smad2 as well as nuclear translocation of Smad2 and Smad3 in HuLM cells, whereas vitamin D significantly reduced all these TGF-beta3-mediated effects.	Vitamin D	132-141	transforming growth factor beta 3	Homo sapiens	174-183
21289245-10	2011	Therefore, our results suggest that vitamin D(3) has consistently reduced TGF-beta3 effects that are involved in the process of fibrosis in human leiomyoma cells.	Vitamin D	36-45	transforming growth factor beta 3	Homo sapiens	74-83
23096068-5	2013	Furthermore, patients with BPPV showed a higher prevalence of decreased serum vitamin D (&lt;20 ng/ml, 80.0 vs. 60.1 %, p &lt; 0.001) than the controls.	Vitamin D	78-87	benign paroxysmal positional vertigo	Homo sapiens	27-31
23096068-7	2013	Our study demonstrated an association between idiopathic BPPV and decreased serum vitamin D.	Vitamin D	82-91	benign paroxysmal positional vertigo	Homo sapiens	57-61
21507305-0	2011	[Effect of maternal vitamin D deficiency on lung morphogenesis and platelet-derived growth factor-A expression in rat offspring].	Vitamin D	20-29	platelet derived growth factor subunit A	Rattus norvegicus	67-99
23096068-8	2013	Decreased serum vitamin D may be a risk factor of BPPV.	Vitamin D	16-25	benign paroxysmal positional vertigo	Homo sapiens	50-54
22740316-0	2013	The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.	Vitamin D	4-13	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	114-119
21507305-10	2011	The levels of PDGF-A mRNA and protein in lungs of fetal and neonatal rats from the vitamin D deficiency group were significantly lower than the controls (P&lt;0.05).	Vitamin D	83-92	platelet derived growth factor subunit A	Rattus norvegicus	14-20
21507305-11	2011	CONCLUSIONS: Maternal vitamin D deficiency during pregnancy may inhibit the development of lung morphogenesis and PDGF-A expression in late fetal and neonatal rats.	Vitamin D	22-31	platelet derived growth factor subunit A	Rattus norvegicus	114-120
21507305-12	2011	The low expression of PDGF-A may be involved in the inhibitory effect of vitamin D deficiency on the lung development.	Vitamin D	73-82	platelet derived growth factor subunit A	Rattus norvegicus	22-28
23392891-3	2013	In this study, we test the hypothesis that the TauT gene is regulated by vitamin D(3) (VD(3)) and retinoic acid (RA) via activation of the vitamin D receptor (VDR) and retinoic acid receptor (RXR).	Vitamin D	73-82	solute carrier family 6 member 6	Homo sapiens	47-51
21177529-1	2011	FGFs have traditionally been associated with cell proliferation, morphogenesis, and development; yet, a subfamily of FGFs (FGF19, -21, and -23) functions as hormones to regulate glucose, lipid, phosphate, and vitamin D metabolism with impact on energy balance and aging.	Vitamin D	209-218	fibroblast growth factor 19	Homo sapiens	123-128
23752060-5	2013	CONCLUSION: Beta amyloid may disrupt the vitamin D-VDR pathway and cause defective utilization of vitamin D by suppressing the level of the VDR and elevating the level of 24OHase.	Vitamin D	98-107	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	171-178
20736132-0	2011	Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.	Vitamin D	0-9	catechol-O-methyltransferase	Homo sapiens	70-98
23875809-6	2013	RESULTS: Improvement of vitamin D status in DD and CDD groups, compared to PD, resulted in a significant increase in Apo A1 (mean changes 0.22 +- 0.38, 0.20 +- 0.27 and 0.01 +- 0.35 g/L, respectively, p = 0.047) and a significant decrease in serum Lp(a) (mean changes -0.08 +- 0.30, -0.08 +- 0.31, and 0.14 +- 0.25 mumol/L, respectively, p = 0.011).	Vitamin D	24-33	lipoprotein(a)	Homo sapiens	248-253
20736132-11	2011	Vitamin D inhibited extracellular signal-regulated kinase activation and down-regulated the expression of BCL-2, BCL-w, CDK1, and PCNA.	Vitamin D	0-9	BCL2 like 2	Homo sapiens	113-118
20736132-12	2011	Western blot, RT-PCR, and enzyme assay of COMT demonstrated inhibitory effects of vitamin D on COMT expression and enzyme activity.	Vitamin D	82-91	catechol-O-methyltransferase	Homo sapiens	42-46
20736132-12	2011	Western blot, RT-PCR, and enzyme assay of COMT demonstrated inhibitory effects of vitamin D on COMT expression and enzyme activity.	Vitamin D	82-91	catechol-O-methyltransferase	Homo sapiens	95-99
23859041-5	2013	DUSP genes interacted with carbohydrates, mutagen index, calories, calcium, vitamin D, lycopene, dietary fats, folic acid, and selenium.	Vitamin D	76-85	dual specificity phosphatase 5	Homo sapiens	0-4
20736132-13	2011	Silencing endogenous COMT expression abolished vitamin D-mediated inhibition of HuLM cell proliferation.	Vitamin D	47-56	catechol-O-methyltransferase	Homo sapiens	21-25
20969950-6	2011	In addition, local vitamin D metabolite concentrations in unmyelinated sensory neurons may be controlled through expression of CYP27B1 and CYP24.	Vitamin D	19-28	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	139-144
23909735-5	2013	This suggests megalin and Dab2 play a central role in uptake of vitamin D and may predict actions of vitamin D in extra-renal tissues.	Vitamin D	64-73	LDL receptor related protein 2	Homo sapiens	14-21
23909735-5	2013	This suggests megalin and Dab2 play a central role in uptake of vitamin D and may predict actions of vitamin D in extra-renal tissues.	Vitamin D	64-73	DAB adaptor protein 2	Homo sapiens	26-30
23909735-5	2013	This suggests megalin and Dab2 play a central role in uptake of vitamin D and may predict actions of vitamin D in extra-renal tissues.	Vitamin D	101-110	LDL receptor related protein 2	Homo sapiens	14-21
23909735-5	2013	This suggests megalin and Dab2 play a central role in uptake of vitamin D and may predict actions of vitamin D in extra-renal tissues.	Vitamin D	101-110	DAB adaptor protein 2	Homo sapiens	26-30
20969950-11	2011	Therefore, unmyelinated CGRP-positive neurons appear to have a distinct vitamin D phenotype with hormonally-regulated ligand and receptor levels.	Vitamin D	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
23074218-0	2012	Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes.	Vitamin D	0-9	solute carrier family 2 member 4	Homo sapiens	23-44
20531451-8	2010	Thus, our findings suggest that dysregulation of CYP24 may be a significant mechanism contributing to vitamin D insufficiency and resistance to vitamin D therapy in CKD.	Vitamin D	144-153	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	49-54
23074218-0	2012	Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes.	Vitamin D	0-9	solute carrier family 2 member 4	Homo sapiens	46-51
22537546-10	2012	EAT from vitamin D-deficient group had significantly higher expression of TNF-alpha, IL-6, MCP-1, and decreased adiponectin in association with increased inflammatory cellular infiltrate.	Vitamin D	9-18	tumor necrosis factor	Sus scrofa	74-83
22537546-10	2012	EAT from vitamin D-deficient group had significantly higher expression of TNF-alpha, IL-6, MCP-1, and decreased adiponectin in association with increased inflammatory cellular infiltrate.	Vitamin D	9-18	interleukin 6	Sus scrofa	85-89
22537547-0	2012	Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation.	Vitamin D	0-9	prohibitin	Mus musculus	57-67
22537547-12	2012	There was significantly increased expression of TNF-alpha and decreased expression of VDR and prohibitin in the lung of vitamin D-deficient mouse model of allergic airway inflammation.	Vitamin D	120-129	prohibitin	Mus musculus	94-104
20531451-8	2010	Thus, our findings suggest that dysregulation of CYP24 may be a significant mechanism contributing to vitamin D insufficiency and resistance to vitamin D therapy in CKD.	Vitamin D	102-111	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	49-54
20432439-7	2010	Mammalian two-hybrid and co-immunoprecipitation assays revealed a vitamin-D-independent interaction between steroid receptor co-activator-1 (SRC-1) and RXRalpha that was reduced by MAPK activation and was restored in RWPE2 cells by mutating S32 and T82 in the RXRalpha AF-1 domain.	Vitamin D	66-75	nuclear receptor coactivator 1	Homo sapiens	108-139
22211698-7	2012	These results suggest that the IL-17-induced pro-inflammatory reaction is enhanced by the activation of PAR2 in keratinocytes, and that the effect of PAR2 is differentially modulated by cyclosporine A, the active form of vitamin D(3)  and glucocorticoids.	Vitamin D	221-230	F2R like trypsin receptor 1	Homo sapiens	150-154
20432439-7	2010	Mammalian two-hybrid and co-immunoprecipitation assays revealed a vitamin-D-independent interaction between steroid receptor co-activator-1 (SRC-1) and RXRalpha that was reduced by MAPK activation and was restored in RWPE2 cells by mutating S32 and T82 in the RXRalpha AF-1 domain.	Vitamin D	66-75	nuclear receptor coactivator 1	Homo sapiens	141-146
20647695-7	2010	Vitamin D increased calcium staining in thoracic aortas and hearts and the expression levels of osteopontin and osteocalcin in mice.	Vitamin D	0-9	secreted phosphoprotein 1	Mus musculus	96-107
22025118-5	2012	Treatment with both vitamin D analogues decreased bone morphogenetic protein 2 but did not modify Runx-2.	Vitamin D	20-29	bone morphogenetic protein 2	Rattus norvegicus	50-78
22623742-5	2012	Mice on dietary vitamin D(3) restriction that responded with an elevation in PTH have an increased risk of infection if they lack 1,25-D3.	Vitamin D	16-25	parathyroid hormone	Mus musculus	77-80
22623742-6	2012	These results identify PTH/PTHrP as a variable that serves to compensate for inadequate vitamin D during activation of antimicrobial peptide production.	Vitamin D	88-97	parathyroid hormone	Mus musculus	23-26
20347976-0	2010	Vitamin D analogues targeting CYP24 in chronic kidney disease.	Vitamin D	0-9	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	30-35
22405472-0	2012	Different doses of supplemental vitamin D maintain interleukin-5 without altering skeletal muscle strength: a randomized, double-blind, placebo-controlled study in vitamin D sufficient adults.	Vitamin D	32-41	interleukin 5	Homo sapiens	51-64
22405472-9	2012	Supplemental vitamin D at 200 IU maintained serum 25(OH)D concentrations and increased IL-5 (P &lt; 0.05).	Vitamin D	13-22	interleukin 5	Homo sapiens	87-91
20347976-1	2010	The cytochrome P450 enzyme 24-hydroxylase (CYP24) plays a critical role in regulating levels of vitamin D hormone.	Vitamin D	96-105	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	4-41
20347976-1	2010	The cytochrome P450 enzyme 24-hydroxylase (CYP24) plays a critical role in regulating levels of vitamin D hormone.	Vitamin D	96-105	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	43-48
20347976-2	2010	Aberrant expression of CYP24 has been implicated in vitamin D insufficiency and resistance to vitamin D therapy.	Vitamin D	52-61	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	23-28
20347976-2	2010	Aberrant expression of CYP24 has been implicated in vitamin D insufficiency and resistance to vitamin D therapy.	Vitamin D	94-103	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	23-28
22207345-0	2012	A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D.	Vitamin D	55-64	ataxia telangiectasia mutated	Mus musculus	43-46
20347976-3	2010	We have demonstrated amplified CYP24 expression in uremic rats, suggesting that CYP24 has an etiological role in vitamin D insufficiency commonly associated with chronic kidney disease (CKD).	Vitamin D	113-122	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	31-36
22207345-9	2012	Together, our findings identify a novel vitamin D-mediated chemopreventive mechanism involving a positive feedback loop between the DNA repair proteins ATM and VDR.	Vitamin D	40-49	ataxia telangiectasia mutated	Mus musculus	152-155
20347976-3	2010	We have demonstrated amplified CYP24 expression in uremic rats, suggesting that CYP24 has an etiological role in vitamin D insufficiency commonly associated with chronic kidney disease (CKD).	Vitamin D	113-122	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	80-85
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	CD14 molecule	Homo sapiens	182-186
20347976-8	2010	These studies indicate that CYP24 inhibition can increase cellular responsiveness to vitamin D hormone and potentiate vitamin D therapy.	Vitamin D	85-94	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	28-33
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	protein C receptor	Homo sapiens	315-345
20347976-8	2010	These studies indicate that CYP24 inhibition can increase cellular responsiveness to vitamin D hormone and potentiate vitamin D therapy.	Vitamin D	118-127	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	28-33
22615584-4	2012	We recently reported that complete ablation of PTH from Fgf23(-/-) mice ameliorated the phenotype in Fgf23(-/-)/PTH(-/-) mice by suppressing serum vitamin D and calcium levels.	Vitamin D	147-156	parathyroid hormone	Mus musculus	47-50
20332274-0	2010	Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients.	Vitamin D	23-32	mutS homolog 2	Homo sapiens	45-49
22615584-4	2012	We recently reported that complete ablation of PTH from Fgf23(-/-) mice ameliorated the phenotype in Fgf23(-/-)/PTH(-/-) mice by suppressing serum vitamin D and calcium levels.	Vitamin D	147-156	parathyroid hormone	Mus musculus	112-115
22536772-3	2012	CKD patients also have higher risk of vitamin D deficiency, due to urinary loss associated with proteinuria and possible down-regulation of megalin in the proximal tubular cells.	Vitamin D	38-47	LDL receptor related protein 2	Homo sapiens	140-147
21907315-4	2011	Typically, the pro-differentiation effects of HGF have required cooperative action with regulatory factors such as vitamin D or bone matrix material.	Vitamin D	115-124	hepatocyte growth factor	Homo sapiens	46-49
20332274-4	2010	After 6 months of treatment, MSH2 expression along the full lengths of crypts increased by 61% (P = 0.11) and 30% (P = 0.36) in the vitamin D and calcium groups, respectively, relative to the placebo group.	Vitamin D	132-141	mutS homolog 2	Homo sapiens	29-33
20332274-5	2010	The estimated calcium and vitamin D treatment effects were more pronounced in the upper 40% of crypts (differentiation zone) in which MSH2 expression increased by 169% (P = 0.04) and 107% (P = 0.13) in the vitamin D and calcium groups, respectively.	Vitamin D	26-35	mutS homolog 2	Homo sapiens	134-138
20332274-5	2010	The estimated calcium and vitamin D treatment effects were more pronounced in the upper 40% of crypts (differentiation zone) in which MSH2 expression increased by 169% (P = 0.04) and 107% (P = 0.13) in the vitamin D and calcium groups, respectively.	Vitamin D	206-215	mutS homolog 2	Homo sapiens	134-138
20147522-0	2010	Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.	Vitamin D	129-138	cyclin dependent kinase 2	Homo sapiens	21-46
21896668-0	2011	PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin D and calcium levels.	Vitamin D	91-100	parathyroid hormone	Mus musculus	0-3
19961857-0	2010	Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.	Vitamin D	74-83	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	21-28
21880026-4	2011	Although, the epidemiologic evidence regarding the association of vitamin D and hepatocellular carcinoma (HCC) is still inconclusive, biochemical evidence clearly indicates that HCC cells are responsive to the inhibitory effect of vitamin D and its analogs.	Vitamin D	66-75	HCC	Homo sapiens	106-109
21880026-4	2011	Although, the epidemiologic evidence regarding the association of vitamin D and hepatocellular carcinoma (HCC) is still inconclusive, biochemical evidence clearly indicates that HCC cells are responsive to the inhibitory effect of vitamin D and its analogs.	Vitamin D	231-240	HCC	Homo sapiens	178-181
21458521-7	2011	Over expression of an active EGFR in vitamin D sensitive ovarian cancer cells caused resistance to 1,25(OH)(2)D(3)-induced growth suppression and diminished the hormonal regulation of cyclin D1, cyclin E, Skp2 and p27, a group of cell cycle regulators that mediate 1,25(OH)(2)D(3)-induced cell cycle arrest at G1-S checkpoint.	Vitamin D	37-46	cyclin D1	Homo sapiens	184-193
21458521-7	2011	Over expression of an active EGFR in vitamin D sensitive ovarian cancer cells caused resistance to 1,25(OH)(2)D(3)-induced growth suppression and diminished the hormonal regulation of cyclin D1, cyclin E, Skp2 and p27, a group of cell cycle regulators that mediate 1,25(OH)(2)D(3)-induced cell cycle arrest at G1-S checkpoint.	Vitamin D	37-46	S-phase kinase associated protein 2	Homo sapiens	205-209
19961857-1	2010	Cytochrome P450 (CYP) 24A1 catalyzes the side-chain oxidation of the hormonal form of vitamin D.	Vitamin D	86-95	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	0-26
19961857-2	2010	Expression of CYP24A1 is up-regulated to attenuate vitamin D signaling associated with calcium homeostasis and cellular growth processes.	Vitamin D	51-60	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	14-21
21901171-7	2011	In addition, increased levels of miR-26a potentiate the antiproliferative effects of 1,25-dihydroxyvitamin D(3) (VitD) and stimulate myeloid differentiation.	Vitamin D	113-117	microRNA 26a-1	Homo sapiens	33-40
19961857-3	2010	The development of therapeutics for disorders linked to vitamin D insufficiency would be greatly facilitated by structural knowledge of CYP24A1.	Vitamin D	56-65	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	136-143
19948723-2	2010	Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin D(3), robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells.	Vitamin D	27-36	nucleotide binding oligomerization domain containing 2	Homo sapiens	129-133
21273498-0	2011	Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States.	Vitamin D	39-48	hemoglobin subunit alpha 1	Homo sapiens	93-97
19948723-2	2010	Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin D(3), robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells.	Vitamin D	27-36	nucleotide binding oligomerization domain containing 2	Homo sapiens	134-140
19948723-2	2010	Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin D(3), robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells.	Vitamin D	27-36	nucleotide binding oligomerization domain containing 2	Homo sapiens	141-145
19948723-7	2010	These studies provide strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition, as Crohn"s pathogenesis is associated with attenuated NOD2 or DEFB2/HBD2 function.	Vitamin D	53-62	nucleotide binding oligomerization domain containing 2	Homo sapiens	213-217
21169421-1	2011	Vitamin D compounds regulate PTH at the transcriptional level, presumably via binding to the vitamin D receptor (VDR), but the exact mechanism is presently unclear.	Vitamin D	0-9	parathyroid hormone	Mus musculus	29-32
21169421-2	2011	We recently reported that the several vitamin D prohormones with low VDR affinity suppressed PTH, even when their activation was inhibited, raising the possibility that their actions may be VDR independent.	Vitamin D	38-47	parathyroid hormone	Mus musculus	93-96
21169421-5	2011	Full suppression of PTH by the native vitamin D hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25 (OH)(2)D(3)], required 2 days, consistent with a transcriptional mechanism, and was reversible, indicating that reduced PTH was not attributable to cell death.	Vitamin D	38-47	parathyroid hormone	Mus musculus	20-23
19648938-1	2009	As of May 1, 2009, Pubmed listed approximately 30,000 citations on the topic of vitamin D in humans, highlighting the medical community"s avid interest in this field.	Vitamin D	80-89	protein kinase C delta	Homo sapiens	6-11
21169421-5	2011	Full suppression of PTH by the native vitamin D hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25 (OH)(2)D(3)], required 2 days, consistent with a transcriptional mechanism, and was reversible, indicating that reduced PTH was not attributable to cell death.	Vitamin D	38-47	parathyroid hormone	Mus musculus	220-223
21169421-7	2011	These findings 1) are the first direct demonstration of the role of the VDR in regulation of PTH by 1alpha,25(OH)(2)D(3), 2) confirm that the suppressive actions of the vitamin D prohormones are mediated by the VDR, and 3) introduce a novel organ culture model that allows the ex vivo study of the function of parathyroid glands from transgenic animals.	Vitamin D	169-178	parathyroid hormone	Mus musculus	93-96
20736132-14	2011	CONCLUSION(S): Vitamin D inhibits growth of HuLM cells through the down-regulation of PCNA, CDK1, and BCL-2 and suppresses COMT expression and activity in HuLM cells.	Vitamin D	15-24	catechol-O-methyltransferase	Homo sapiens	123-127
20800785-11	2010	Vitamin D also increases synthesis of interleukin 10 by CD4+CD25+Foxp3+ T-regulatory cells and dendritic cells, while concurrently inhibiting dendritic cell activation by downregulating expression of costimulatory molecules CD40 and CD80/86.	Vitamin D	0-9	interleukin 2 receptor subunit alpha	Homo sapiens	60-64
20800785-11	2010	Vitamin D also increases synthesis of interleukin 10 by CD4+CD25+Foxp3+ T-regulatory cells and dendritic cells, while concurrently inhibiting dendritic cell activation by downregulating expression of costimulatory molecules CD40 and CD80/86.	Vitamin D	0-9	CD40 molecule	Homo sapiens	224-228
20800785-11	2010	Vitamin D also increases synthesis of interleukin 10 by CD4+CD25+Foxp3+ T-regulatory cells and dendritic cells, while concurrently inhibiting dendritic cell activation by downregulating expression of costimulatory molecules CD40 and CD80/86.	Vitamin D	0-9	CD80 molecule	Homo sapiens	233-237
20554701-1	2010	20,23-Dihydroxyvitamin D(3) [20,23(OH)(2)D(3)] is a biologically active metabolite produced by the action of cytochrome P450scc (CYP11A1) on vitamin D(3).	Vitamin D	15-24	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	129-136
19629189-5	2009	The calcium assimilation hypothesis suggests that carriers of the lactase persistence allele(s) (LCT*P) are favoured in high-latitude regions, where sunshine is insufficient to allow accurate vitamin-D synthesis.	Vitamin D	192-201	lactase	Homo sapiens	66-73
19241402-0	2009	New insights on therapy with vitamin D analogs targeting the intracellular pathways that control repigmentation in human vitiligo.	Vitamin D	29-38	VAMAS6	Homo sapiens	121-129
20399919-2	2010	The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a crucial regulator of this process and increases the expression of the transient receptor potential vanilloid 6 (Trpv6) calcium channel that mediates calcium transfer across the intestinal apical membrane.	Vitamin D	19-28	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	151-191
20399919-2	2010	The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a crucial regulator of this process and increases the expression of the transient receptor potential vanilloid 6 (Trpv6) calcium channel that mediates calcium transfer across the intestinal apical membrane.	Vitamin D	19-28	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	193-198
19241402-2	2009	A number of studies have recently reported that the treatment with vitamin D compounds or their combination with ultraviolet light or corticosteroids enhances repigmentation in vitiligo; however, the causal relationship at the cellular and molecular levels has not so far been investigated.	Vitamin D	67-76	VAMAS6	Homo sapiens	177-185
19299728-8	2009	Following treatment with 19 kDa, expression of hCAP: 1) correlated with 25OHD levels in serum culture supplements (R = 0.649, p &lt; 0.001); 2) was significantly enhanced by exogenous 25OHD (5 nM); and 3) was significantly enhanced with serum from vivo vitamin D-supplemented patients.	Vitamin D	253-262	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	47-54
20701717-2	2010	The complex metabolic abnormalities observed in CKD such as vitamin D deficiency, obesity, metabolic acidosis, inflammation, and accumulation of "uremic toxins" are believed to contribute to the etiology of IR and acquired defects in the insulin-receptor signaling pathway in this patient population.	Vitamin D	60-69	insulin receptor	Homo sapiens	238-254
19106481-1	2009	The effect(s) of oral calcium and vitamin D(3) were examined on the expression of duodenal and renal active calcium transport genes, i.e., calbindin-D9k (CaBP-9k) and calbindin-D28k (CaBP-28k), transient receptor potential cation channels (TRPV5 and TRPV6), Na(+)/Ca(2+) exchanger 1 (NCX1) and plasma membrane calcium ATPase 1b (PMCA1b), in CaBP-9k KO mice.	Vitamin D	34-43	S100 calcium binding protein G	Mus musculus	139-152
18981260-5	2009	The degree of the PXR-mediated locking of SMRT depends on the relative concentration of vitamin D(3) to the human PXR activator rifampicin; SMRT increased its dissociation as this ratio increased.	Vitamin D	88-97	nuclear receptor corepressor 2	Homo sapiens	42-46
20030662-0	2010	Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood.	Vitamin D	9-18	leukocyte immunoglobulin like receptor B2	Homo sapiens	81-85
20030662-4	2010	OBJECTIVE: To evaluate the association between prenatal vitamin D supplementation and tolerogenic antigen-presenting cells in cord blood (CB) as determined by mRNA measurement of immunoglobulin-like transcripts (ILT)3 and ILT4.	Vitamin D	56-65	leukocyte immunoglobulin like receptor B2	Homo sapiens	222-226
20030662-9	2010	RESULTS: Maternal vitamin D supplementation during pregnancy was associated with an increase in the gene expression of ILT3 (P=0.012) and ILT4 (P&lt;0.001).	Vitamin D	18-27	leukocyte immunoglobulin like receptor B2	Homo sapiens	138-142
18981260-5	2009	The degree of the PXR-mediated locking of SMRT depends on the relative concentration of vitamin D(3) to the human PXR activator rifampicin; SMRT increased its dissociation as this ratio increased.	Vitamin D	88-97	nuclear receptor corepressor 2	Homo sapiens	140-144
20030662-11	2010	CONCLUSIONS: Vitamin D supplementation during pregnancy may increase the mRNA levels of ILT3 and ILT4 in CB.	Vitamin D	13-22	leukocyte immunoglobulin like receptor B2	Homo sapiens	97-101
19301089-11	2009	In group 1 (risedronate plus calcium/vitamin D-treated patients), serum levels of RANKL and IL-1beta significantly decreased and the level of osteoprotegerin significantly increased after three and 6 months, but no significant difference was found in TNF-alpha level.	Vitamin D	37-46	TNF receptor superfamily member 11b	Homo sapiens	142-157
20138028-1	2010	The tumor suppressor vitamin D(3) up-regulated protein 1 (VDUP1) is expressed throughout the developing and mature Drosophila nervous system, but its regulatory pathways are not well understood.	Vitamin D	21-30	Vitamin D[[3]] up-regulated protein 1	Drosophila melanogaster	58-63
19073396-10	2008	CONCLUSION: In female patients elastase 1 in feces confirm the grade of vitamin D supply, and thus show a vitamin D subset3-deficiency, depending on the loss of stool content.	Vitamin D	72-81	chymotrypsin like elastase 1	Homo sapiens	31-41
19073396-10	2008	CONCLUSION: In female patients elastase 1 in feces confirm the grade of vitamin D supply, and thus show a vitamin D subset3-deficiency, depending on the loss of stool content.	Vitamin D	106-115	chymotrypsin like elastase 1	Homo sapiens	31-41
19857615-0	2010	Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis.	Vitamin D	125-134	bone morphogenetic protein 2	Homo sapiens	167-171
19779497-0	2010	p73 is essential for vitamin D-mediated osteoblastic differentiation.	Vitamin D	21-30	tumor protein p73	Homo sapiens	0-3
19073396-11	2008	There seems to be a connection here between the loss of exocrine function and may be even the characteristic of sterol-binding of elastase 1 in the pancreas, which seems to be relevant for vitamin D-supply.	Vitamin D	189-198	chymotrypsin like elastase 1	Homo sapiens	130-140
19779497-8	2010	Together, our data implicate a novel function for p73 in vitamin D-mediated differentiation of human osteosarcoma cells.	Vitamin D	57-66	tumor protein p73	Homo sapiens	50-53
18829467-1	2008	FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion.	Vitamin D	170-179	fibroblast growth factor 19	Homo sapiens	0-5
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	pro-opiomelanocortin-alpha	Mus musculus	20-24
18829467-1	2008	FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion.	Vitamin D	170-179	fibroblast growth factor 19	Homo sapiens	26-31
18832725-5	2008	Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors.	Vitamin D	39-48	homeobox A10	Homo sapiens	117-124
18769117-0	2008	HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling.	Vitamin D	88-97	histone deacetylase 3	Homo sapiens	0-5
20110921-0	2010	Does serum osteoprotegerin level relate to fragility fracture in elderly women with low vitamin D status?	Vitamin D	88-97	TNF receptor superfamily member 11b	Homo sapiens	11-26
20008294-5	2010	We found that vitamin D induces IkappaBalpha, an NF-kappaB inhibitor, in airway epithelium and decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and CXCL10.	Vitamin D	14-23	interferon beta 1	Homo sapiens	153-161
19683963-6	2009	In particular, "hormone-like" FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined.	Vitamin D	126-135	fibroblast growth factor 19	Homo sapiens	30-35
18769117-5	2008	Gene expression profiling of SW480 revealed that HDAC3 shRNA impacted the expression of genes in the Wnt and vitamin D signaling pathways.	Vitamin D	109-118	histone deacetylase 3	Homo sapiens	49-54
19474191-1	2009	1Alpha,25(OH)(2) vitamin D(3) [1,25(OH)(2)D(3)] increases serum Ca(2+) concentration in vivo, an action counteracted by activation of the Ca(2+)-sensing receptor (CaSR), which decreases parathyroid hormone (PTH) secretion and increases renal Ca(2+) excretion.	Vitamin D	17-26	calcium-sensing receptor	Mus musculus	163-167
18769117-10	2008	We propose that HDAC3 overexpression alters the epigenetic programming of colon cancer cells to impact intracellular Wnt signaling and their sensitivity to external growth regulation by vitamin D.	Vitamin D	186-195	histone deacetylase 3	Homo sapiens	16-21
19474191-1	2009	1Alpha,25(OH)(2) vitamin D(3) [1,25(OH)(2)D(3)] increases serum Ca(2+) concentration in vivo, an action counteracted by activation of the Ca(2+)-sensing receptor (CaSR), which decreases parathyroid hormone (PTH) secretion and increases renal Ca(2+) excretion.	Vitamin D	17-26	parathyroid hormone	Mus musculus	207-210
18633342-3	2008	Time-dependent Cox regression models, after adjustment for potential confounders, showed that the 7,203 patients who received oral active vitamin D had significant reductions in overall, cardiovascular, infectious and neoplastic mortality compared to the 8,801 patients that had not received vitamin D.	Vitamin D	138-147	cytochrome c oxidase subunit 8A	Homo sapiens	15-18
17568787-3	2008	Disturbances in calcium and vitamin D metabolism that arise owing to CKD diminish the level of activation of the CaSR, leading to increases in PTH secretion, PTH synthesis, and parathyroid gland hyperplasia.	Vitamin D	28-37	calcium-sensing receptor	Mus musculus	113-117
19264720-1	2009	Our goal was to determine if breastfeeding provides any protection against urinary tract infection (UTI) and if vitamin D supplementation imposes any additional risks for UTI in infants &lt; 3 months of age.	Vitamin D	112-121	alpha-1-microglobulin/bikunin precursor	Homo sapiens	171-174
19264720-6	2009	Vitamin D supplementation increased the UTI risk, with a relative risk of 1.76 (1.07-2.91, P &lt; .05).	Vitamin D	0-9	alpha-1-microglobulin/bikunin precursor	Homo sapiens	40-43
19264720-7	2009	However, only formula-fed infants showed an increased risk of UTI after vitamin D supplementation.	Vitamin D	72-81	alpha-1-microglobulin/bikunin precursor	Homo sapiens	62-65
18550936-4	2008	We also found that a novel nonsense polymorphism in the aminopeptidase-A gene was associated with hypertension among postmenopausal women (hazard ratio, 1.54; 95% CI, 1.01-2.37), women with inadequate calcium intake (hazard ratio, 2.47; 95% CI, 1.29-4.72) and, marginally, women with inadequate vitamin D intake.	Vitamin D	295-304	glutamyl aminopeptidase	Homo sapiens	56-72
19546862-9	2009	Animal studies have implicated a role for TRPV5 in idiopathic hypercalciuria and vitamin D-dependent rickets, although these observations have not been confirmed in patients.	Vitamin D	81-90	transient receptor potential cation channel subfamily V member 5	Homo sapiens	42-47
18550936-5	2008	In addition, angiotensin-converting enzyme and AT1R A1166C polymorphisms were associated or marginally associated with incident hypertension among postmenopausal women and those with inadequate calcium and vitamin D intakes.	Vitamin D	206-215	angiotensin II receptor type 1	Homo sapiens	47-51
18029472-6	2007	High VD3 restored expression of vitamin D-regulated genes in intestine (calbindin D(9K)) and kidney (CYP27B1, 24-hydroxylase, calbindin D(9K)) of KO mice.	Vitamin D	32-41	S100 calcium binding protein G	Mus musculus	72-86
19246678-8	2009	Here, we show that high expression levels of OPN in acute myocarditis are associated with consecutive development of extensive fibrosis that can be reduced by treatment with a vitamin D analog.	Vitamin D	176-185	secreted phosphoprotein 1	Mus musculus	45-48
17449905-3	2007	We report that 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], the most active vitamin D metabolite, increases the level of DKK-1 RNA and protein in human SW480-ADH colon cancer cells.	Vitamin D	34-43	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	121-126
17591692-8	2007	Furthermore, impairment of agonist-stimulated activity by SMRT depletion is specific to ERalpha and not observed for receptors for vitamin D, androgen, or thyroid hormone.	Vitamin D	131-140	nuclear receptor corepressor 2	Homo sapiens	58-62
19176352-8	2009	These data indicate that vitamin D is involved in energy metabolism and adipocyte biology in vivo in part through regulation of beta-oxidation and UCP expression.	Vitamin D	25-34	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	147-150
17855664-8	2007	Targeted down-regulation of NCoR1 and SMRT by small interference RNA was able to restore CWR22R-2 response to vitamin D.	Vitamin D	110-119	nuclear receptor corepressor 2	Homo sapiens	38-42
18797846-5	2009	Besides, decreased expression levels of cyp2r1 and cyp27b1 (-26 and -39%, respectively, P &lt; 0.01) were measured in liver and kidney suggesting a physiological adaptation in response to the rise in vitamin D level.	Vitamin D	200-209	cytochrome P450, family 2, subfamily r, polypeptide 1	Rattus norvegicus	40-46
19280452-4	2009	In the presence of 4MP, DAS, or the anti-oxidants vitamin D or catalase, there was a substantial decrease in the ability of ethanol to stimulate CCN2 mRNA expression and a concomitant decrease in CCN2-positive PSC.	Vitamin D	50-59	cellular communication network factor 2	Mus musculus	145-149
19280452-4	2009	In the presence of 4MP, DAS, or the anti-oxidants vitamin D or catalase, there was a substantial decrease in the ability of ethanol to stimulate CCN2 mRNA expression and a concomitant decrease in CCN2-positive PSC.	Vitamin D	50-59	cellular communication network factor 2	Mus musculus	196-200
17855664-9	2007	Together, we showed that increased NCoR1 and SMRT expression in CWR22R-2 cells resulted in reduced VDR-mediated transcriptional activity and attenuated antiproliferative response to vitamin D.	Vitamin D	182-191	nuclear receptor corepressor 2	Homo sapiens	45-49
17346947-5	2007	In addition, the highly Ca(2+)-selective channel, TRPV5, contributes to several acquired mineral (dys)regulation, such as diabetes mellitus (DM), acid-base disorders, diuretics, immunosuppressant agents, and vitamin D analogues-associated Ca(2+) imbalance whereas TRPV4 may function as an osmoreceptor in kidney and participate in the regulation of sodium and water balance.	Vitamin D	208-217	transient receptor potential cation channel subfamily V member 5	Homo sapiens	50-55
19139565-3	2009	Here we have shown that TLR9 is highly expressed by human Treg secreting the antiinflammatory cytokine IL-10 induced following stimulation of blood and tissue CD3+ T cells in the presence of 1alpha,25-dihydroxyvitamin D3 (1alpha25VitD3), the active form of Vitamin D, with or without the glucocorticoid dexamethasone.	Vitamin D	257-266	toll like receptor 9	Homo sapiens	24-28
18683889-5	2009	Treatment of dermal fibroblasts with vitamin D(3) induced expression of BMP-4 (1.2 +/- 0.2, 1.7 +/- 0.2, and 1.8 +/- 0.2 relative fold increase) and BMP-6 (9.1 +/- 0.3, 23.3 +/- 2.1, and 30.4 +/- 3.0 relative fold increase) at 3, 14, and 21 days, respectively.	Vitamin D	37-46	bone morphogenetic protein 4	Homo sapiens	72-77
19098224-4	2009	Consistent with this, VDR and SMRT are recruited to the vitamin D response element of the endogenous osteocalcin promoter in the absence of 1alpha,25-(OH)(2)D(3) in chromatin immunoprecipitation assays.	Vitamin D	56-65	nuclear receptor corepressor 2	Homo sapiens	30-34
17207766-0	2007	Hybrid homology modeling and mutational analysis of cytochrome P450C24A1 (CYP24A1) of the Vitamin D pathway: insights into substrate specificity and membrane bound structure-function.	Vitamin D	90-99	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	52-72
18767932-1	2009	Cell proliferation and PTH secretion in the parathyroid gland are known to be regulated by vitamin D and extracellular calcium.	Vitamin D	91-100	parathyroid hormone	Mus musculus	23-26
17207766-0	2007	Hybrid homology modeling and mutational analysis of cytochrome P450C24A1 (CYP24A1) of the Vitamin D pathway: insights into substrate specificity and membrane bound structure-function.	Vitamin D	90-99	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	74-81
17207766-1	2007	Cytochrome P450C24A1 (CYP24A1), a peripheral inner mitochondrial membrane hemoprotein and candidate oncogene, regulates the side-chain metabolism and biological function of vitamin D and many of its related analog drugs.	Vitamin D	173-182	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	0-20
17207766-1	2007	Cytochrome P450C24A1 (CYP24A1), a peripheral inner mitochondrial membrane hemoprotein and candidate oncogene, regulates the side-chain metabolism and biological function of vitamin D and many of its related analog drugs.	Vitamin D	173-182	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	22-29
19399172-5	2009	Signals emanating from CD40 are important, as CD40(-/-) DCs treated with B7-DC XAb (DC(XAb)) activated DAP12, but failed to activate NFkappaB, and were not protected from cell death upon cytokine withdrawal or treatment with Vitamin D(3).	Vitamin D	225-234	CD40 molecule	Homo sapiens	23-27
17224269-9	2007	In conclusion, our findings demonstrate that expression of sCLU modulates growth regulatory effects of 1,25(OH)(2)D(3) in prostate cancer indicating that CLU interferes with vitamin D signalling pathways.	Vitamin D	174-183	clusterin	Homo sapiens	60-63
17254779-3	2007	Amazingly, there is ample precedence for the antiproliferative action of vitamin-D-related compounds and their role as endocrine suppressors of renin biosynthesis.	Vitamin D	73-82	renin	Rattus norvegicus	144-149
19073913-1	2008	The requirement for TRPV6 for vitamin D-dependent intestinal calcium absorption in vivo has been examined by using vitamin D-deficient TRPV6 null mice and littermate wild-type mice.	Vitamin D	30-39	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	20-25
19073913-1	2008	The requirement for TRPV6 for vitamin D-dependent intestinal calcium absorption in vivo has been examined by using vitamin D-deficient TRPV6 null mice and littermate wild-type mice.	Vitamin D	115-124	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	135-140
19073913-5	2008	These and previous results using calbindin D9k null mutant mice illustrate that molecular events in the intestinal calcium absorption process in response to the active form of vitamin D remain to be defined.	Vitamin D	176-185	S100 calcium binding protein G	Mus musculus	33-46
17267207-5	2007	In contrast, renal 25-hydroxyvitamin D 24-hydroxylase (CYP24) mRNA levels increased as dietary vitamin D increased achieving maximum levels in animals receiving 500 ng vitamin D/day.	Vitamin D	29-38	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	55-60
17267207-5	2007	In contrast, renal 25-hydroxyvitamin D 24-hydroxylase (CYP24) mRNA levels increased as dietary vitamin D increased achieving maximum levels in animals receiving 500 ng vitamin D/day.	Vitamin D	95-104	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	55-60
19083488-8	2008	In conclusion, elevated whey protein, calcium, and vitamin D intake resulted in reduced accumulation of body fat mass and increased lean mass, with a commensurate increase in insulin receptor expression, regardless of the level of calories from fat or sucrose.	Vitamin D	51-60	insulin receptor	Rattus norvegicus	175-191
16927309-7	2007	Interestingly, TGFbeta and Vitamin D-mediated transcription of osteoblast genes (except for osteopontin) required the presence of Runx2.	Vitamin D	27-36	secreted phosphoprotein 1	Mus musculus	92-103
19035286-0	2008	Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.	Vitamin D	0-9	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	79-87
18559986-9	2008	These data suggest that the regulation of extracellular matrix mineralization by DMP1 is coupled to renal phosphate handling and vitamin D metabolism through a DMP1-dependent regulation of FGF23 production by osteocytes.	Vitamin D	129-138	dentin matrix protein 1	Mus musculus	81-85
18559986-9	2008	These data suggest that the regulation of extracellular matrix mineralization by DMP1 is coupled to renal phosphate handling and vitamin D metabolism through a DMP1-dependent regulation of FGF23 production by osteocytes.	Vitamin D	129-138	dentin matrix protein 1	Mus musculus	160-164
17168675-11	2006	Genomic expression profile with vitamin D indicated differential expression of gene targets such as c-JUN, JUNB, JUND, FREAC-1/FoxF1, ZNF-44/KOX7, plectin, filamin, and keratin-13, involved in antiproliferative, differentiation pathways.	Vitamin D	32-41	JunB proto-oncogene, AP-1 transcription factor subunit	Sus scrofa	107-111
17168675-11	2006	Genomic expression profile with vitamin D indicated differential expression of gene targets such as c-JUN, JUNB, JUND, FREAC-1/FoxF1, ZNF-44/KOX7, plectin, filamin, and keratin-13, involved in antiproliferative, differentiation pathways.	Vitamin D	32-41	FOXF1	Sus scrofa	127-132
18348265-0	2008	Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog.	Vitamin D	86-95	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	24-40
18348265-0	2008	Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog.	Vitamin D	86-95	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	42-47
16842832-6	2006	Recombinant human CYP2J2 was overexpressed in Escherichia coli, purified, and assayed for vitamin D 25-hydroxylation activity.	Vitamin D	90-99	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	18-24
18852532-1	2008	BACKGROUND: Vitamin D compounds are effective in managing elevated PTH levels in secondary hyperparathyroidism (SHPT) of renal failure.	Vitamin D	12-21	parathyroid hormone	Mus musculus	67-70
18626245-10	2008	Furthermore, the findings in the index case present interesting novel aspects, including a previously undescribed coexistence of the 3-kb STX16 deletion and AHO-like features and a clinical course complicated by concomitant 25-[OH]-vitamin D deficiency, which may have resulted, at least partly, from long-term use of antiepileptic drugs.	Vitamin D	232-241	syntaxin 16	Homo sapiens	138-143
16842832-8	2006	Interestingly, human CYP2J2 hydroxylated vitamin D2, an exogenous vitamin D, at a higher rate than it did vitamin D3, an endogenous vitamin D, whereas, rat CYP2J3 hydroxylated vitamin D3 (1.4 min(-1)) more efficiently than vitamin D2 (0.86 min(-1)).	Vitamin D	41-50	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
16842832-8	2006	Interestingly, human CYP2J2 hydroxylated vitamin D2, an exogenous vitamin D, at a higher rate than it did vitamin D3, an endogenous vitamin D, whereas, rat CYP2J3 hydroxylated vitamin D3 (1.4 min(-1)) more efficiently than vitamin D2 (0.86 min(-1)).	Vitamin D	66-75	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	21-27
16889531-4	2006	Interestingly, vitamin D and RA demonstrated a consistent, dose-dependent enhancement of osteogenesis and upregulated osteoblast specific markers including osteopontin and osteocalcin.	Vitamin D	15-24	secreted phosphoprotein 1	Mus musculus	156-167
18615397-7	2008	It seems that in DM2 patients the most purposeful strategy could be the popularization of healthy attitudes aiming the elimination of unfavorable dietetic and environmental factors, such as low physical activity, smoking, and low vitamin D intake, as well as education against falls.	Vitamin D	230-239	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	17-20
18182065-6	2008	Intestinal CaBP-9k is involved in intestinal calcium absorption, and is regulated at the transcriptional and post-transcriptional levels by 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D.	Vitamin D	154-163	S100 calcium binding protein G	Mus musculus	11-18
17237623-6	2006	The vitamin D analogs modulated cell cycle regulators, including decreasing mRNA and protein levels of p21(Waf1/Cip1) (p21) and cyclin-dependent kinase 2 (cdk2), and increasing p27(Kip1) (p27) protein expression.	Vitamin D	4-13	cyclin dependent kinase 2	Homo sapiens	128-153
18565252-13	2008	Treatment of L OA osteoblasts with osteotropic factors revealed that the OPG/RANKL mRNA expression ratio was significantly reduced by vitamin D(3) and significantly increased by TNF-alpha, PTH and PGE(2), while IL-1Beta demonstrated no effect.	Vitamin D	134-143	TNF receptor superfamily member 11b	Homo sapiens	73-76
17237623-6	2006	The vitamin D analogs modulated cell cycle regulators, including decreasing mRNA and protein levels of p21(Waf1/Cip1) (p21) and cyclin-dependent kinase 2 (cdk2), and increasing p27(Kip1) (p27) protein expression.	Vitamin D	4-13	cyclin dependent kinase 2	Homo sapiens	155-159
17237623-7	2006	Vitamin D analogs induced apoptosis, caspase-3 cleavage and increased expression of pro-apoptotic MEKK-1.	Vitamin D	0-9	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	98-104
18040268-8	2008	OPG secretion was upregulated by anti-CD3 antibody stimulation or incubation with interleukin (IL)-4, IL-1beta, TNF-alpha, GM-CSF, and vitamin D(3).	Vitamin D	135-144	TNF receptor superfamily member 11b	Homo sapiens	0-3
16323060-4	2005	The study was also designed to investigate whether vitamin D might influence interleukin-6 (IL-6) and metalloproteinase-2 (MMP-2) production in a co-culture of T47D cell spheroids with an endothelial cell monolayer in the presence of beta-estradiol and TAM.	Vitamin D	51-60	matrix metallopeptidase 2	Homo sapiens	123-128
18211694-13	2008	The latter, together with findings demonstrating specific effects of calcitriol acting through the VDR and the cAMP/PKA signaling pathway upon hCG expression and secretion, indicate that there is a functional vitamin D endocrine system in the placenta, and recognize calcitriol as an autocrine regulator of hCG.	Vitamin D	209-218	hypertrichosis 2 (generalised, congenital)	Homo sapiens	143-146
16323060-8	2005	Addition of vitamin D further inhibited MMP-2 production, but enhanced the production of IL-6 as was shown by ELISA assay.	Vitamin D	12-21	matrix metallopeptidase 2	Homo sapiens	40-45
18211694-13	2008	The latter, together with findings demonstrating specific effects of calcitriol acting through the VDR and the cAMP/PKA signaling pathway upon hCG expression and secretion, indicate that there is a functional vitamin D endocrine system in the placenta, and recognize calcitriol as an autocrine regulator of hCG.	Vitamin D	209-218	hypertrichosis 2 (generalised, congenital)	Homo sapiens	307-310
15836435-7	2005	We report, in the present study, the identification of a site located at -171/-163, about 30 bp upstream of the vitamin D response element-1 in the CYP24 proximal promoter.	Vitamin D	112-121	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	148-153
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	246-282
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	284-295
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	peroxisome proliferator activated receptor gamma	Mus musculus	301-349
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	peroxisome proliferator activated receptor gamma	Mus musculus	351-361
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	peroxisome proliferator activated receptor gamma	Mus musculus	392-402
18254883-3	2008	The latter action may reflect a vitamin D-induced decrease in endogenous PPAR gamma ligand availability and a competition between VDR and PPAR gamma for a limiting amount of retinoid X receptor (RXR), a common heterodimeric binding partner of both nuclear receptors.	Vitamin D	32-41	peroxisome proliferator activated receptor gamma	Mus musculus	73-83
15836435-8	2005	This sequence, 5"-TGTCGGTCA-3", is critical for 1,25D induction of CYP24 and is therefore termed the vitamin D stimulatory element.	Vitamin D	101-110	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	67-72
15849313-0	2005	The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements.	Vitamin D	59-68	potassium voltage-gated channel interacting protein 3	Homo sapiens	14-19
17849744-14	2007	Vitamin D insufficiency was associated with increased age, BMI, and SBP, and decreased HDL-C.	Vitamin D	0-9	selenium binding protein 1	Homo sapiens	68-71
17470996-4	2007	1alpha hydroxylase plays a key role for final activation of vitamin D, which is canonically regulated by parathyroid hormone (PTH) .	Vitamin D	60-69	parathyroid hormone	Mus musculus	105-124
17470996-4	2007	1alpha hydroxylase plays a key role for final activation of vitamin D, which is canonically regulated by parathyroid hormone (PTH) .	Vitamin D	60-69	parathyroid hormone	Mus musculus	126-129
15849313-3	2005	In this work, we find that DREAM stimulates basal and ligand-dependent activation of promoters containing vitamin D and retinoic acid response elements (VDREs and RAREs), consisting of direct repeats of the sequence AGT/GTCA spaced by 3 or 5 nt, respectively.	Vitamin D	106-115	potassium voltage-gated channel interacting protein 3	Homo sapiens	27-32
17339340-1	2007	Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis.	Vitamin D	157-166	fibroblast growth factor 19	Homo sapiens	47-52
15605102-0	2004	[Expression of OPG and RANKL at protein level in human periodontal ligament cells and the effect of 1alpha,25(OH)(2) vitamin D(3) on the secretion of OPG protein in vitro].	Vitamin D	117-126	TNF receptor superfamily member 11b	Homo sapiens	150-153
17207617-0	2007	Differential expression of prohibitin is correlated with dual action of Vitamin D as a proliferative and antiproliferative hormone in breast epithelial cells.	Vitamin D	72-81	prohibitin 1	Homo sapiens	27-37
17207617-3	2007	Other binding sites for EGR and GR which are also Vitamin D target genes were identified in this region, indicating that prohibitin is a potential target gene for Vitamin D.	Vitamin D	50-59	prohibitin 1	Homo sapiens	121-131
17207617-3	2007	Other binding sites for EGR and GR which are also Vitamin D target genes were identified in this region, indicating that prohibitin is a potential target gene for Vitamin D.	Vitamin D	163-172	prohibitin 1	Homo sapiens	121-131
17207617-4	2007	The combination of multiple binding sites also provides a basis for a possible dual regulation of prohibitin by Vitamin D.	Vitamin D	112-121	prohibitin 1	Homo sapiens	98-108
17207617-5	2007	Prohibitin upregulation by 1alpha(OH)D(5) treatment at both transcription and translation level was observed in Vitamin D sensitive BT474 breast cancer cells, in which 1alpha(OH)D(5) significantly inhibited cell proliferation in normal culture condition.	Vitamin D	112-121	prohibitin 1	Homo sapiens	0-10
15322146-1	2004	The hormonal form of vitamin D(3), 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), is an immune system modulator and induces expression of the TLR coreceptor CD14.	Vitamin D	21-30	CD14 molecule	Homo sapiens	156-160
17207617-6	2007	On the other hand, prohibitin down-regulation accompanied with Vitamin D mediated maintenance of proliferation of breast epithelial cells was observed under stressed condition.	Vitamin D	63-72	prohibitin 1	Homo sapiens	19-29
17207617-7	2007	These results demonstrated that Vitamin D mediated antiproliferative activity in unstressed condition and growth maintaining activity under stressed condition involve differential expression of prohibitin.	Vitamin D	32-41	prohibitin 1	Homo sapiens	194-204
15178414-2	2004	Based on cDNA microarray results, we found that long-chain fatty-acid-CoA ligase 3 (FACL3/ACS3) might play an important role in vitamin D(3) and androgen regulation of LNCaP cell growth.	Vitamin D	128-137	acyl-CoA synthetase long chain family member 3	Homo sapiens	48-82
15178414-2	2004	Based on cDNA microarray results, we found that long-chain fatty-acid-CoA ligase 3 (FACL3/ACS3) might play an important role in vitamin D(3) and androgen regulation of LNCaP cell growth.	Vitamin D	128-137	acyl-CoA synthetase long chain family member 3	Homo sapiens	84-89
16855859-7	2007	Two other vitamin D(3) metabolites, 25(OH)D(3) and 24,25(OH)(2)D(3, )also enhanced p38 phosphorylation, and to a similar extent than 1alpha,25(OH)(2)D(3), an ability that is lost with ageing.	Vitamin D	10-19	mitogen activated protein kinase 14	Rattus norvegicus	83-86
15178414-2	2004	Based on cDNA microarray results, we found that long-chain fatty-acid-CoA ligase 3 (FACL3/ACS3) might play an important role in vitamin D(3) and androgen regulation of LNCaP cell growth.	Vitamin D	128-137	acyl-CoA synthetase long chain family member 3	Homo sapiens	90-94
15178414-9	2004	The upregulation of FACL3/ACS3 expression by vitamin D(3) was recovered by the addition of DHT in DCC-serum medium.	Vitamin D	45-54	acyl-CoA synthetase long chain family member 3	Homo sapiens	20-25
15178414-9	2004	The upregulation of FACL3/ACS3 expression by vitamin D(3) was recovered by the addition of DHT in DCC-serum medium.	Vitamin D	45-54	acyl-CoA synthetase long chain family member 3	Homo sapiens	26-30
15200683-0	2004	Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed.	Vitamin D	12-21	potassium calcium-activated channel subfamily N member 4	Homo sapiens	66-70
17129178-5	2007	Trpv6 encodes a Ca(2+)-permeable cation channel responsible for vitamin D-dependent intestinal Ca(2+) absorption.	Vitamin D	64-73	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	0-5
17161336-4	2006	The effects of the vitamin D system on calcium and bone homeostasis are largely mediated by promoting active intestinal calcium transport via the induction of the epithelial calcium channel TRPV6.	Vitamin D	19-28	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	190-195
15200683-5	2004	RESULTS: hIK1 mRNA expression in human keratinocytes and skin was increased in response to anti-proliferative/pro-differentiating stimuli (elevated calcium and Vitamin D).	Vitamin D	160-169	potassium calcium-activated channel subfamily N member 4	Homo sapiens	9-13
16502312-5	2006	Cytochrome P450 (CYP27A1, CYP2R1, CYP27B1, CYP24A1) enzymes involved in vitamin D metabolism and two vitamin D(3)-target genes (ECaC1, CaBP-D9K) were assessed by real time RT-PCR in liver and kidneys.	Vitamin D	72-81	cytochrome P450, family 2, subfamily r, polypeptide 1	Rattus norvegicus	26-32
16502312-5	2006	Cytochrome P450 (CYP27A1, CYP2R1, CYP27B1, CYP24A1) enzymes involved in vitamin D metabolism and two vitamin D(3)-target genes (ECaC1, CaBP-D9K) were assessed by real time RT-PCR in liver and kidneys.	Vitamin D	72-81	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	43-50
15225765-2	2004	As a result, CYP24 is an important multifunctional regulatory enzyme that maintains essential tissue-levels of Vitamin D hormone.	Vitamin D	111-120	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	13-18
16502312-12	2006	This work shows for the first time that DU acute contamination modulates both activity and expression of CYP enzymes involved in vitamin D metabolism in liver and kidney, and consequently affects vitamin D target genes levels.	Vitamin D	129-138	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	105-108
16502312-12	2006	This work shows for the first time that DU acute contamination modulates both activity and expression of CYP enzymes involved in vitamin D metabolism in liver and kidney, and consequently affects vitamin D target genes levels.	Vitamin D	196-205	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	105-108
15225769-0	2004	Emerging insights into the coactivator role of NCoA62/SKIP in Vitamin D-mediated transcription.	Vitamin D	62-71	SNW domain containing 1	Homo sapiens	47-53
15225769-4	2004	Chromatin immunoprecipitation studies show that NCoA62/SKIP is recruited in a 1,25-(OH)(2)D(3)-dependent manner to native Vitamin D responsive gene promoters and it enters these promoter complexes after VDR and SRC entry.	Vitamin D	122-131	SNW domain containing 1	Homo sapiens	48-54
15225829-5	2004	At early stages of renal failure, vitamin D therapy efficiently counteracts uremia- and high phosphorus-induced hyperplasia by inhibiting the increases in parathyroid-TGFalpha/EGFR co-expression.	Vitamin D	34-43	transforming growth factor alpha	Homo sapiens	167-175
16849588-0	2006	Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells.	Vitamin D	37-46	prohibitin 1	Homo sapiens	0-10
16849588-2	2006	In this report, we evaluated the functional significance of prohibitin in relation to the cellular response to vitamin D.	Vitamin D	111-120	prohibitin 1	Homo sapiens	60-70
15225829-6	2004	In established hyperparathyroidism, characterized by highly enhanced-TGFalpha/EGFR co-expression, vitamin D therapy arrests growth by suppressing EGFR-growth signals from the plasma membrane and nuclear EGFR actions as a transactivator of the cyclin D1 gene, an important contributor to parathyroid hyperplasia in humans.	Vitamin D	98-107	transforming growth factor alpha	Homo sapiens	69-77
16849588-4	2006	Prohibitin up-regulation by 1alpha(OH)D5 treatment at both transcriptional and translational levels was confirmed by real-time reverse transcription-PCR and Western blot analysis in breast cancer cells, identifying prohibitin as a vitamin D target gene.	Vitamin D	231-240	prohibitin 1	Homo sapiens	0-10
16849588-4	2006	Prohibitin up-regulation by 1alpha(OH)D5 treatment at both transcriptional and translational levels was confirmed by real-time reverse transcription-PCR and Western blot analysis in breast cancer cells, identifying prohibitin as a vitamin D target gene.	Vitamin D	231-240	prohibitin 1	Homo sapiens	215-225
15225829-6	2004	In established hyperparathyroidism, characterized by highly enhanced-TGFalpha/EGFR co-expression, vitamin D therapy arrests growth by suppressing EGFR-growth signals from the plasma membrane and nuclear EGFR actions as a transactivator of the cyclin D1 gene, an important contributor to parathyroid hyperplasia in humans.	Vitamin D	98-107	cyclin D1	Homo sapiens	243-252
16849588-6	2006	In MCF-7 cells expressing tetracycline-inducible prohibitin (Tet-On model), the overexpression of prohibitin inhibited cell proliferation and enhanced vitamin D-induced antiproliferative activity.	Vitamin D	151-160	prohibitin 1	Homo sapiens	49-59
16849588-6	2006	In MCF-7 cells expressing tetracycline-inducible prohibitin (Tet-On model), the overexpression of prohibitin inhibited cell proliferation and enhanced vitamin D-induced antiproliferative activity.	Vitamin D	151-160	prohibitin 1	Homo sapiens	98-108
15225838-4	2004	In the neonatal rat, low prenatal vitamin D(3) in utero leads to increased brain size, altered brain shape, enlarged ventricles, reduced expression of nerve growth factors, reduced expression of the low affinity p75 receptor and increased cellular proliferation.	Vitamin D	34-43	nerve growth factor receptor	Rattus norvegicus	212-215
15183687-11	2004	Dex or BMP-2 treatment alone did not affect the basic osteocalcin levels, but in combination with vitamin D, BMP-2 increased the osteocalcin production, while Dex treatment completely suppressed osteocalcin production.	Vitamin D	98-107	bone morphogenetic protein 2	Homo sapiens	109-114
15040831-0	2004	FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis.	Vitamin D	32-41	fibroblast growth factor 23	Rattus norvegicus	0-6
16886681-8	2006	Treatment with 1,25(OH)2D3 modulated CLU"s expression in vitamin D-responsive but not in -resistant melanoma cell lines.	Vitamin D	57-66	clusterin	Homo sapiens	37-40
16464653-10	2006	Moreover, TM patients with low 25-OH-vitamin D levels were significantly older (P &lt; 0.05) and had higher GPT (P &lt; 0.05) than patients with normal vitamin D.	Vitamin D	37-46	glutamic--pyruvic transaminase	Homo sapiens	108-111
16533909-8	2006	These results indicate that the activation of BMP/Smad signaling by the Gemini vitamin D(3) analog Ro3582 may be through the production of BMP ligands, including BMP-2 and BMP-6, and/or down-regulation of the inhibitory Smad6.	Vitamin D	79-88	SMAD family member 1	Homo sapiens	50-54
16533909-8	2006	These results indicate that the activation of BMP/Smad signaling by the Gemini vitamin D(3) analog Ro3582 may be through the production of BMP ligands, including BMP-2 and BMP-6, and/or down-regulation of the inhibitory Smad6.	Vitamin D	79-88	bone morphogenetic protein 2	Homo sapiens	162-167
15040831-2	2004	FGF-23 caused a reduction in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia.	Vitamin D	49-58	fibroblast growth factor 23	Rattus norvegicus	0-6
15040831-3	2004	This study indicates that FGF-23 is a potent regulator of the vitamin D and phosphate metabolism.	Vitamin D	62-71	fibroblast growth factor 23	Rattus norvegicus	26-32
16566955-1	2006	The Radial Distribution Function (RDF) approach has been applied to the study of the chick intestinal VDR affinity of 49 Vitamin D analogues.	Vitamin D	121-130	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	102-105
15040831-11	2004	FGF-23 reduced renal mRNA for 25-hydroxyvitamin D-1alpha-hydroxylase and increased that for 25-hydroxyvitamin D-24-hydroxylase starting at 1 h. In addition, an injection of calcitriol into normal mice increased the serum FGF-23 level within 4 h. CONCLUSIONS: FGF-23 regulates NaPi-2a independently of PTH and the serum 1,25(OH)2D level by controlling renal expressions of key enzymes of the vitamin D metabolism.	Vitamin D	40-49	fibroblast growth factor 23	Rattus norvegicus	0-6
16502013-2	2006	Cyclooxygenase-2 expression is regulated by retinoic acid receptors, which form heterodimers with vitamin D receptors and vitamin D.	Vitamin D	98-107	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-16
16522742-1	2006	Farnesoid X receptor (FXR), the receptor for bile acids, including chenodeoxycholic acid (CDCA), is a member of the nuclear receptor superfamily, which also includes the receptors for retinoic acid, vitamin D (D3), thyroid hormone, thiazolidinedione and 22(R)-hydroxycholesterol.	Vitamin D	199-208	nuclear receptor subfamily 1 group H member 4	Homo sapiens	22-25
16483768-6	2006	Examination of the regulation of VDR target gene mRNA in DU-145 cells revealed that co-treatment of 1,25-(OH)(2)D(3) plus inhibitor of Vitamin D(3) metabolising enzymes co-ordinately upregulated CYP24, p21(waf1/cip1) and GADD45alpha.	Vitamin D	135-144	growth arrest and DNA damage inducible alpha	Homo sapiens	221-232
15040831-12	2004	In conclusion, FGF-23 is a potent regulator of phosphate and vitamin D homeostasis.	Vitamin D	61-70	fibroblast growth factor 23	Rattus norvegicus	15-21
14961167-1	2004	Matrix-Gla Protein (MGP) is a strong inhibitor of vascular calcification, the expression of which is vitamin D dependent.	Vitamin D	101-110	matrix Gla protein	Homo sapiens	0-18
16243370-3	2006	This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR).	Vitamin D	39-48	parathyroid hormone like hormone	Homo sapiens	73-78
16160737-13	2005	These studies emphasize that much remains to be learned regarding the normal regulation of vitamin D metabolism and bone formation in response to PTH and PTHrP in humans.	Vitamin D	91-100	parathyroid hormone like hormone	Homo sapiens	154-159
16055326-0	2005	Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog.	Vitamin D	89-98	RB transcriptional corepressor 1	Homo sapiens	24-56
16043444-6	2005	Regression analyses showed that women were more likely to be vitamin D deficient than men (odds ratio (OR) 2.1) and deficiency was associated with limiting longstanding illness (OR 3.57), manual social classes (OR 2.4), poor general health (OR 1.92) and body mass index&lt;25 kg/m2 (OR 2.02), and was 67% more likely among informants in the winter/autumn.	Vitamin D	61-70	olfactory receptor family 6 subfamily B member 2	Homo sapiens	91-110
15905361-3	2005	In this study, we identified a direct role of vitamin D in the regulation of HOXA10 in primary human endometrial stromal cells, the human endometrial stromal cell line (HESC), and in the human myelomonocytic cell line, U937.	Vitamin D	46-55	homeobox A10	Homo sapiens	77-83
15905361-10	2005	Direct regulation of HOXA10 by vitamin D has implications for fertility and myeloid differentiation.	Vitamin D	31-40	homeobox A10	Homo sapiens	21-27
15883024-0	2005	Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal.	Vitamin D	0-9	transient receptor potential cation channel subfamily V member 5	Homo sapiens	36-41
15752725-8	2005	Based on these results, the enzyme(s) responsible for the epimerization of vitamin D(3) at C-3 are thought to be located in microsomes and different from cytochrome P450 and HSE.	Vitamin D	75-84	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	174-177
15531762-12	2005	Therefore, we proposed there was a feedback loop existing among serum phosphorus, 1alpha,25(OH)(2)D(3), and FGF-23, in which the novel phosphate-regulating bone-kidney axis integrated with the parathyroid hormone-vitamin D(3) axis in regulating phosphate homeostasis.	Vitamin D	213-222	fibroblast growth factor 23	Rattus norvegicus	108-114
15831076-7	2005	The factors that control PTHrP production via interaction with the promoters are growth factors, androgens, vitamin D analogs, and adenoviral proteins.	Vitamin D	108-117	parathyroid hormone like hormone	Homo sapiens	25-30
15456794-1	2004	Calbindin (CaBP)-D28k and CaBP-D9k are cytosolic vitamin D-dependent calcium-binding proteins long thought to play an important role in transepithelial calcium transport.	Vitamin D	49-58	S100 calcium binding protein G	Mus musculus	11-15
15456794-1	2004	Calbindin (CaBP)-D28k and CaBP-D9k are cytosolic vitamin D-dependent calcium-binding proteins long thought to play an important role in transepithelial calcium transport.	Vitamin D	49-58	S100 calcium binding protein G	Mus musculus	26-34
14988426-8	2004	We show that Nurr1 and vitamin D activate the OPN promoter in a synergistic fashion, whereas Nurr1-mediated transactivation of the OPN promoter is repressed by estrogen-related receptors.	Vitamin D	23-32	secreted phosphoprotein 1	Mus musculus	46-49
14758446-8	2004	Higher IL1 expression was detected in islets of vitamin D-deficient mice and their peritoneal macrophages had an aberrant cytokine profile (low IL1 and IL6, high IL15).	Vitamin D	48-57	interleukin 1 complex	Mus musculus	7-10
14758446-8	2004	Higher IL1 expression was detected in islets of vitamin D-deficient mice and their peritoneal macrophages had an aberrant cytokine profile (low IL1 and IL6, high IL15).	Vitamin D	48-57	interleukin 1 complex	Mus musculus	144-147
15084353-11	2004	However, only in female-derived cells were ERalpha and ERbeta upregulated by pretreatment with Vitamin D analogs.	Vitamin D	95-104	estrogen receptor 2	Homo sapiens	55-61
14678293-4	2004	Numerous cytokines and hormones (TGF-beta, PTH, vitamin D, glucocorticoids and oestrogens) exert their effects on osteoclastogenesis by regulating the production of OPG.	Vitamin D	48-57	TNF receptor superfamily member 11b	Homo sapiens	165-168
14679186-5	2003	Here, we demonstrate that mice lacking TRPV5 display diminished active Ca2+ reabsorption despite enhanced vitamin D levels, causing severe hypercalciuria.	Vitamin D	106-115	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	39-44
14507860-0	2003	Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma.	Vitamin D	0-9	RB transcriptional corepressor 1	Homo sapiens	83-97
14507860-1	2003	PURPOSE: To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma.	Vitamin D	47-56	RB transcriptional corepressor 1	Homo sapiens	97-111
12865334-7	2003	In contrast, in vitro osteoclast formation in bone marrow from IL-7R-deficient (IL-7R KO) mice showed a significant decrease in tartrate-resistant acid phosphatase(+) OCL numbers in cultures that were stimulated with vitamin D(3), PTH, RANKL, or M-CSF and RANKL.	Vitamin D	217-226	interleukin 7 receptor	Mus musculus	63-68
12865334-7	2003	In contrast, in vitro osteoclast formation in bone marrow from IL-7R-deficient (IL-7R KO) mice showed a significant decrease in tartrate-resistant acid phosphatase(+) OCL numbers in cultures that were stimulated with vitamin D(3), PTH, RANKL, or M-CSF and RANKL.	Vitamin D	217-226	interleukin 7 receptor	Mus musculus	80-85
12890894-5	2003	As expected, vitamin D(2) and vitamin D(3) were found to be selective inhibitors of mammalian DNA polymerase alpha (pol alpha) with IC(50) values of 123 and 96 micro M, respectively.	Vitamin D	13-22	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	94-114
12890894-5	2003	As expected, vitamin D(2) and vitamin D(3) were found to be selective inhibitors of mammalian DNA polymerase alpha (pol alpha) with IC(50) values of 123 and 96 micro M, respectively.	Vitamin D	13-22	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	116-125
12890894-5	2003	As expected, vitamin D(2) and vitamin D(3) were found to be selective inhibitors of mammalian DNA polymerase alpha (pol alpha) with IC(50) values of 123 and 96 micro M, respectively.	Vitamin D	30-39	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	94-114
12890894-5	2003	As expected, vitamin D(2) and vitamin D(3) were found to be selective inhibitors of mammalian DNA polymerase alpha (pol alpha) with IC(50) values of 123 and 96 micro M, respectively.	Vitamin D	30-39	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	116-125
12890894-7	2003	Interestingly, vitamin D(3)-3beta-sulfate was a much stronger pol alpha inhibitor with an IC(50) value of 7.1 micro M. Vitamin D(2), vitamin D(3), and vitamin D(3)-3beta-sulfate could prevent the growth of NUGC-3 human gastric cancer cells with LD(50) values of 133, 77, and 44 micro M, respectively, but provitamin D(2) and provitamin D(3) could not.	Vitamin D	119-128	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	62-71
12890894-7	2003	Interestingly, vitamin D(3)-3beta-sulfate was a much stronger pol alpha inhibitor with an IC(50) value of 7.1 micro M. Vitamin D(2), vitamin D(3), and vitamin D(3)-3beta-sulfate could prevent the growth of NUGC-3 human gastric cancer cells with LD(50) values of 133, 77, and 44 micro M, respectively, but provitamin D(2) and provitamin D(3) could not.	Vitamin D	15-24	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	62-71
12850281-4	2003	The human PTHrP gene contains a sequence element homologous to the negative vitamin D response element within the parathyroid hormone gene.	Vitamin D	76-85	parathyroid hormone like hormone	Homo sapiens	10-15
12759183-4	2003	Using cultured embryonic hippocampal cells and explants we found the addition of vitamin D(3) significantly decreases the percentage of cultured hippocampal cells undergoing mitosis in conjunction with increases in both neurite outgrowth and NGF production.	Vitamin D	81-90	nerve growth factor	Rattus norvegicus	242-245
14961167-1	2004	Matrix-Gla Protein (MGP) is a strong inhibitor of vascular calcification, the expression of which is vitamin D dependent.	Vitamin D	101-110	matrix Gla protein	Homo sapiens	20-23
12671190-4	2003	A recent study suggests that megalin, a member of the LDLR gene family that mediates the cellular uptake of vitamin D carrier protein, may also modulate vitamin D-related gene transcription through sequestration of a component of the vitamin D receptor transcriptional complex.	Vitamin D	108-117	LDL receptor related protein 2	Homo sapiens	29-36
12671190-4	2003	A recent study suggests that megalin, a member of the LDLR gene family that mediates the cellular uptake of vitamin D carrier protein, may also modulate vitamin D-related gene transcription through sequestration of a component of the vitamin D receptor transcriptional complex.	Vitamin D	153-162	LDL receptor related protein 2	Homo sapiens	29-36
15609106-0	2004	Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity.	Vitamin D	0-9	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Mus musculus	52-59
12520535-8	2003	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular ECaC2 or TRPV6) is strongly vitamin D dependent and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D dependent active calcium absorption.	Vitamin D	135-144	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	107-112
12520535-8	2003	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular ECaC2 or TRPV6) is strongly vitamin D dependent and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D dependent active calcium absorption.	Vitamin D	135-144	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	116-121
14506229-4	2003	A DR3-type vitamin D response element was identified in the fourth exon of GADD45 that forms a complex with the vitamin D receptor.retinoid X receptor heterodimer in electrophoresis mobility shift assays and mediates the dose-dependent induction of luciferase activity by 1,25-dihydroxyvitamin D3 in reporter assays.	Vitamin D	11-20	growth arrest and DNA damage inducible alpha	Homo sapiens	75-81
12559378-2	2003	In both a single-dosing study with normal rats and a repeated-dosing study with hypercalcemic rats (induced by chronic vitamin-D dosing), we consistently observed that the hypocalcemic effect of calcitonin was greater when the drug was given at 14 h after lights on than that at 2 h after lights on.	Vitamin D	119-128	calcitonin-related polypeptide alpha	Rattus norvegicus	195-205
12393416-3	2003	Vitamin D(3) also induced phosphorylation of Smad2/3 and monocytic differentiation; however the effects were indirect, dependent on its ability to induce expression of TGF-beta1.	Vitamin D	0-9	SMAD family member 2	Homo sapiens	45-52
12954644-0	2003	Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.	Vitamin D	0-9	cyclin dependent kinase 2	Homo sapiens	104-108
12548017-4	2002	Interestingly, low concentrations of derivatives of vitamin D, which were insufficient to induce any detectable changes in the cell cycle traverse, markedly increased the levels of total pRb, which was highly phosphorylated.	Vitamin D	52-61	RB transcriptional corepressor 1	Homo sapiens	187-190
12408227-0	2002	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells.	Vitamin D	0-9	S-phase kinase associated protein 2	Homo sapiens	93-97
14607878-5	2003	Using a monoclonal antibody to the vitamin D receptor (VDR) as a VDR agonist, we confirmed that activation of the vitamin D pathway profoundly depresses antigen-specific, but not mitogenic, bovine peripheral blood T-cell responses (proliferation and gamma interferon production).	Vitamin D	35-44	vitamin D receptor	Bos taurus	55-58
14607878-5	2003	Using a monoclonal antibody to the vitamin D receptor (VDR) as a VDR agonist, we confirmed that activation of the vitamin D pathway profoundly depresses antigen-specific, but not mitogenic, bovine peripheral blood T-cell responses (proliferation and gamma interferon production).	Vitamin D	35-44	vitamin D receptor	Bos taurus	65-68
14569082-5	2003	Furthermore, several putative vitamin D-responsive elements were detected upstream of the mouse TRPV6 start codon, and 1,25(OH)(2)D(3) treatment significantly increased renal TRPV6 mRNA and protein expression.	Vitamin D	30-39	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	96-101
14569082-5	2003	Furthermore, several putative vitamin D-responsive elements were detected upstream of the mouse TRPV6 start codon, and 1,25(OH)(2)D(3) treatment significantly increased renal TRPV6 mRNA and protein expression.	Vitamin D	30-39	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	175-180
12796488-3	2003	2MD stimulates the expression of several vitamin D-sensitive genes including 25-hydroxyvitamin D3-24 hydroxylase (Cyp24), osteopontin and receptor activator of NF kappa B ligand and suppresses osteoprotegerin at concentrations two logs lower than that for 1,25(OH)2D3.	Vitamin D	41-50	TNF receptor superfamily member 11b	Homo sapiens	193-208
12929933-11	2003	The induction of rickets by a vitamin D-deficient diet reduced the expression levels of gelatinase B in the growth plate of 12-day-old chickens but did not affect the expression of gelatinase A mRNA.	Vitamin D	30-39	matrix metallopeptidase 9	Mus musculus	88-100
12727200-0	2003	Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.	Vitamin D	0-9	parathyroid hormone like hormone	Homo sapiens	106-111
12727200-0	2003	Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.	Vitamin D	72-81	parathyroid hormone like hormone	Homo sapiens	106-111
12727200-0	2003	Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.	Vitamin D	152-161	parathyroid hormone like hormone	Homo sapiens	106-111
12480707-6	2003	Moreover, siRNA-mediated AML1/MTG8 suppression results in changes in cell shape and, in combination with TGF beta(1)/vitamin D(3), severely reduces clonogenicity of Kasumi-1 cells.	Vitamin D	117-126	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	30-34
12670492-8	2003	The results implicate that both CYP2D25 and CYP27A1 contribute to the 25-hydroxylation in hepatocytes and are important in the bioactivation of vitamin D(3).	Vitamin D	144-153	cytochrome P450 family 27 subfamily A member 1	Sus scrofa	44-51
12788662-11	2003	The addition of monoclonal anti-TGF-beta(1) antibody to the medium of RM4 cells exposed to vitamin D(3) alone or in combination with MEL increased the [3H]thymidine uptake compared to the correspondent cells cultured without antibody.	Vitamin D	91-100	transforming growth factor, beta 1	Mus musculus	32-42
12711007-0	2003	Identification of a Vitamin D response element in the human insulin receptor gene promoter.	Vitamin D	20-29	insulin receptor	Homo sapiens	60-76
12711007-1	2003	The present study was designed to explore the possible presence and location of Vitamin D response elements (VDREs) in the human insulin receptor (hIR) gene promoter.	Vitamin D	80-89	insulin receptor	Homo sapiens	129-145
12584041-10	2003	In a separate 6-month prospective study of 14 heart transplant recipients receiving calcium and vitamin D serum OPG levels fell by 41% (P = 0.0004) after 3 months and 47% (P = 0.0001) after 6 months following cardiac transplantation.	Vitamin D	96-105	TNF receptor superfamily member 11b	Homo sapiens	112-115
12467655-5	2003	The excess of vitamin D stimulates CaBP synthesis and calcium and phosphate absorption, producing hypercalcemia and/or hyperphosphatemia.	Vitamin D	14-23	S100 calcium binding protein G	Bos taurus	35-39
12432570-1	2002	In the present study, we examined whether anti-CD40+IL-4-mediated B cell proliferation and immunoglobulin synthesis is affected by vitamin D (VD) and its low-hypercalcemic analogue EB1089 in Bcells from healthy donors.	Vitamin D	131-140	CD40 molecule	Homo sapiens	47-51
12372434-1	2002	Vitamin D-24-hydroxylase (CYP24) is one of the enzymes responsible for vitamin D metabolism.	Vitamin D	71-80	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	26-31
12372434-3	2002	CYP24 is also involved in the breakdown of 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], the active form of vitamin D(3).	Vitamin D	62-71	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	0-5
12372434-9	2002	These unexpected results suggest that CYP24 is involved in functions other than the regulation of vitamin D metabolism.	Vitamin D	98-107	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	38-43
12144717-1	2002	The work presented here examines the possible effects of nutritional deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat.	Vitamin D	141-150	GC, vitamin D binding protein	Rattus norvegicus	172-197
15775398-2	2002	For example, vitamin D(3) was reported to enhance vascular calcification by suppressing PTHrP action that is an inhibitor of calcification.	Vitamin D	13-22	parathyroid hormone like hormone	Homo sapiens	88-93
12202471-1	2002	VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women.	Vitamin D	39-48	cytochrome c oxidase subunit 8A	Homo sapiens	0-4
12054486-6	2002	In rats fed a 0.47% calcium diet (+Ca) supplemented with vitamin D (4 microg/day), exogenous 1,25-(OH)(2)D(3) suppressed renal 1alpha-OHase and stimulated the 24-OHase.	Vitamin D	57-66	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	159-167
12054486-8	2002	In contrast, vitamin D was fully able to stimulate intestinal 24-OHase.	Vitamin D	13-22	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	62-70
12139403-6	2002	Vitamin D (1,25-(OH)2D3) and thyroid hormone (T3) led to an increase in Nas1 promoter activity in OK cells.	Vitamin D	0-9	solute carrier family 13 member 1	Homo sapiens	72-76
12139403-7	2002	Mutational analysis of the Nas1 promoter resulted in identification of a direct repeat 6-type vitamin-D-responsive element (DR6 VDRE) at -525 to -508 and an imperfect inverted repeat 0-type T3 responsive element (IRO T3RE) at -426 to -425 which conferred 1,25-(OH)2D3 and T3 responsiveness respectively.	Vitamin D	94-103	solute carrier family 13 member 1	Homo sapiens	27-31
12139403-8	2002	These findings suggest for vitamin D and thyroid hormone regulation of NaS(i)-1, may provide important clues to the physiological control of sulfate homeostasis.	Vitamin D	27-36	solute carrier family 13 member 1	Homo sapiens	71-79
11717447-6	2001	Dogs with an inherited disorder affecting cubilin biosynthesis exhibit abnormal vitamin D metabolism.	Vitamin D	80-89	cubilin	Canis lupus familiaris	42-49
11687634-8	2001	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular CaT1) is strongly vitamin D-dependent, and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D-dependent active calcium absorption.	Vitamin D	125-134	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	107-111
11687634-8	2001	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular CaT1) is strongly vitamin D-dependent, and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D-dependent active calcium absorption.	Vitamin D	277-286	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	107-111
11687634-8	2001	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular CaT1) is strongly vitamin D-dependent, and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D-dependent active calcium absorption.	Vitamin D	277-286	S100 calcium binding protein G	Mus musculus	197-211
11577149-3	2001	The results in this paper show that the mechanism of stimulation by porins of THP-1 cells enriched in CD14 receptor after treatment with 1,25-dihydroxyvitamin D(3) (vitamin D(3)) is independent of this receptor, but is partially dependent on CD11a/18 integrins.	Vitamin D	151-160	CD14 molecule	Homo sapiens	102-106
12198242-2	2002	To understand regulatory mechanisms involved, we asked whether the inducible cAMP early repressor (ICER), which serves as a dominant negative regulator of cAMP-induced transcription in other endocrine systems, may similarly play a role in modulation of vitamin D hormone action.	Vitamin D	253-262	cAMP responsive element modulator	Rattus norvegicus	67-97
12198242-2	2002	To understand regulatory mechanisms involved, we asked whether the inducible cAMP early repressor (ICER), which serves as a dominant negative regulator of cAMP-induced transcription in other endocrine systems, may similarly play a role in modulation of vitamin D hormone action.	Vitamin D	253-262	cAMP responsive element modulator	Rattus norvegicus	99-103
12198242-5	2002	The vitamin D response element is sufficient for the PKA enhancement of VDR-mediated transcription and is also sufficient to observe the inhibitory effect of ICER.	Vitamin D	4-13	cAMP responsive element modulator	Rattus norvegicus	158-162
12198242-7	2002	This study provides evidence for the first time that ICER has a key regulatory role in the PKA enhancement of VDR transcription and therefore in the cross-talk between the PKA signaling pathway and the vitamin D endocrine system.	Vitamin D	202-211	cAMP responsive element modulator	Rattus norvegicus	53-57
12145693-0	2002	Combination of 22-oxa-1,25-dihydroxyvitamin D(3), a vitamin D(3) derivative, with vitamin K(2) (VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells.	Vitamin D	36-45	OXA1L mitochondrial inner membrane protein	Homo sapiens	18-23
12145693-3	2002	A novel synthetic vitamin D(3)derivative, 22-oxa-1,25-dihydroxyvitamin D(3) (OCT: oxacarcitriol) shows a more potent differentiation-inducing ability among myeloid leukemia cells in vitro with much lesser extent of the induction of hypercalcemia in vivo as compared to the effects of 1alpha,25(OH)(2)D(3).	Vitamin D	18-27	OXA1L mitochondrial inner membrane protein	Homo sapiens	45-50
12093529-6	2002	In contrast to the fact that the plasma/serum concentration of the former is much lower than that of the latter, the hydroxylation at the C-23 position was considered to be the important side-chain modification of 25(OH)D(3) to excrete the excess vitamin D(3) in man.	Vitamin D	247-256	nucleolin	Homo sapiens	138-142
11991950-1	2002	The fully active dihydroxylated metabolite of vitamin D(3) induces the expression of CYP3A4 and, to a lesser extent, CYP2B6 and CYP2C9 genes in normal differentiated primary human hepatocytes.	Vitamin D	46-55	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	117-123
10875229-1	2000	The promoter of the calbindin-D 9k (CaBP9k) gene, previously analyzed in transgenic mice, contains all of the information necessary for expression of a transgene similar to the endogenous gene and also for an appropriate response to vitamin D.	Vitamin D	233-242	S100 calcium binding protein G	Mus musculus	20-34
10875229-1	2000	The promoter of the calbindin-D 9k (CaBP9k) gene, previously analyzed in transgenic mice, contains all of the information necessary for expression of a transgene similar to the endogenous gene and also for an appropriate response to vitamin D.	Vitamin D	233-242	S100 calcium binding protein G	Mus musculus	36-42
10875229-2	2000	In the present study we first investigated the role of a putative vitamin D-responsive element (9k/VDRE), located at nucleotides -489 to -445 on the rat CaBP9k promoter gene, using transgenic mice.	Vitamin D	66-75	S100 calcium binding protein G	Mus musculus	153-159
10875229-7	2000	These data together with the fact that vitamin D-responsive sequences are present in a two-module region (from -3731 to -2894 and/or -117 to +365) and that this region does not contain any classical VDRE show that the CaBP9k gene is submitted to a non-conventional control by vitamin D.	Vitamin D	39-48	S100 calcium binding protein G	Mus musculus	218-224
10875229-7	2000	These data together with the fact that vitamin D-responsive sequences are present in a two-module region (from -3731 to -2894 and/or -117 to +365) and that this region does not contain any classical VDRE show that the CaBP9k gene is submitted to a non-conventional control by vitamin D.	Vitamin D	276-285	S100 calcium binding protein G	Mus musculus	218-224
10825392-1	2000	The vitamin D receptor (VDR) is the nuclear receptor for 1, 25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] that acts as a ligand-dependent transcription factor via combined contact with coactivator proteins (steroid receptor coactivator-1, transcriptional intermediary factor 2, and receptor associated coactivator 3) and specific DNA binding sites [vitamin D response elements (VDREs)].	Vitamin D	4-13	nuclear receptor coactivator 2	Homo sapiens	241-278
10662728-5	2000	ClC-5 mRNA and protein levels in the cortex decrease in vitamin D-deficient, thyroparathyroidectomized rats compared with both control and vitamin D-deficient animals.	Vitamin D	56-65	chloride voltage-gated channel 5	Rattus norvegicus	0-5
10662728-5	2000	ClC-5 mRNA and protein levels in the cortex decrease in vitamin D-deficient, thyroparathyroidectomized rats compared with both control and vitamin D-deficient animals.	Vitamin D	139-148	chloride voltage-gated channel 5	Rattus norvegicus	0-5
10662728-6	2000	ClC-5 mRNA and protein expression increase near to control levels in vitamin D-deficient, thyroparathyroidectomized rats injected with PTH.	Vitamin D	69-78	chloride voltage-gated channel 5	Rattus norvegicus	0-5
10617584-2	2000	Transcription of the rat CYP24 gene is induced by 1, 25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) through two vitamin D response elements (VDREs).	Vitamin D	65-74	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	25-30
11595822-1	2000	Vitamin D and retinoic acid (RA) receptors (VDRs and RARs, respectively), bind as heterodimers with the retinoid X receptor (RXR) to hormone response elements (HREs) in target genes.	Vitamin D	0-9	arginyl-tRNA synthetase 1	Homo sapiens	53-57
10550414-0	1999	A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.	Vitamin D	2-11	nerve growth factor	Rattus norvegicus	43-62
10441375-6	1999	Also, mRNA and protein levels of calbindin-D9k were similar in vitamin D-deficient wild-type and op/op mice as well as in wild-type and op/op mice treated with 1, 25-dihydroxyvitamin D(3).	Vitamin D	63-72	S100 calcium binding protein G	Mus musculus	33-46
10234571-2	1999	Several analogs were examined for their effects on DNA binding of the vitamin D receptor (VDR) homodimer complex with the murine osteopontin vitamin D response element.	Vitamin D	70-79	secreted phosphoprotein 1	Mus musculus	129-140
10068443-1	1999	Vitamin D receptor (VDR) regulates the expression of vitamin D-dependent genes upon binding to its cognate ligand, 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	53-62	vitamin D receptor	Bos taurus	0-18
10068443-1	1999	Vitamin D receptor (VDR) regulates the expression of vitamin D-dependent genes upon binding to its cognate ligand, 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	53-62	vitamin D receptor	Bos taurus	20-23
9801142-1	1998	1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65.	Vitamin D	19-28	RELA proto-oncogene, NF-kB subunit	Homo sapiens	223-226
12003610-1	2002	BACKGROUND: Although calcitriol (1,25-dihydroxycholecalciferol) and vitamin D(2) inhibit retinoblastoma growth in the athymic (nude) mouse xenograft (Y-79 cell line) model of retinoblastoma, they can cause severe toxicity.	Vitamin D	68-77	RB transcriptional corepressor 1	Homo sapiens	89-103
12003610-12	2002	CONCLUSION: A vitamin D analogue, 1alpha-OH-D(2), inhibits tumor growth in this xenograft model of retinoblastoma with less toxicity than calcitriol and vitamin D(2).	Vitamin D	14-23	RB transcriptional corepressor 1	Homo sapiens	99-113
9824486-0	1998	Vitamin D differentially regulates B7.1 and B7.2 expression on human peripheral blood monocytes.	Vitamin D	0-9	CD86 molecule	Homo sapiens	44-48
9784422-0	1998	Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines.	Vitamin D	78-87	TNF receptor superfamily member 11b	Homo sapiens	0-15
11832333-8	2002	Our data also suggest that the effect of 1,25-(OH)(2) vitamin D(3) on NaP(i)-IIb expression is at least partially mediated by gene transcription in suckling rats.	Vitamin D	54-63	solute carrier family 34 member 2	Homo sapiens	70-80
9738509-0	1998	Effect of combination treatment with a vitamin D analog (OCT) and a bisphosphonate (AHPrBP) in a nude mouse model of cancer-associated hypercalcemia.	Vitamin D	39-48	plexin A2	Mus musculus	57-60
11741335-2	2001	Vitamin D-responsive elements (VDRE) were detected in the promoter sequence of human ECaC1 and regulation of ECaC by the steroid hormone 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) has been postulated.	Vitamin D	0-9	transient receptor potential cation channel subfamily V member 5	Homo sapiens	85-90
9603973-1	1998	Identification of a vitamin D-responsive element in the human NAPi-3 gene.	Vitamin D	20-29	solute carrier family 34 member 1	Homo sapiens	62-68
9603973-7	1998	A deletion and mutation analysis of the NaPi-3 gene promoter identified the vitamin D-responsive element as the sequence 5"-GGGGCAGCAAGGGCA-3" nucleotides -1977 to -1963 relative to the transcription start site.	Vitamin D	76-85	solute carrier family 34 member 1	Homo sapiens	40-46
11527993-5	2001	Conversely, monocytic differentiation with vitamin D(3) inhibited surface expression and SDF-1-mediated chemotaxis, even as it induced [(35)S]GTPgammaS binding and calcium flux by more than twofold.	Vitamin D	43-52	C-X-C motif chemokine ligand 12	Homo sapiens	89-94
11331275-4	2001	Here, we demonstrate that the growth-promoting/pro-survival signaling molecule mitogen-activated protein kinase kinase (MEK) is cleaved in a caspase-dependent manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D(3).	Vitamin D	259-268	midkine	Mus musculus	79-118
9556566-0	1998	A negative vitamin D response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D.	Vitamin D	11-20	parathyroid hormone like hormone	Homo sapiens	55-90
11331275-4	2001	Here, we demonstrate that the growth-promoting/pro-survival signaling molecule mitogen-activated protein kinase kinase (MEK) is cleaved in a caspase-dependent manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D(3).	Vitamin D	259-268	midkine	Mus musculus	120-123
11331275-10	2001	We propose that vitamin D(3) induces apoptosis in SCC cells by a unique mechanism involving selective caspase-dependent MEK cleavage and up-regulation of MEKK-1.	Vitamin D	16-25	midkine	Mus musculus	120-123
11331275-11	2001	Additional evidence is provided that vitamin D(3)-induced apoptosis may be mediated via p38 MAPK.	Vitamin D	37-46	mitogen-activated protein kinase 14	Mus musculus	88-96
9556566-0	1998	A negative vitamin D response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D.	Vitamin D	105-114	parathyroid hormone like hormone	Homo sapiens	55-90
9556566-1	1998	We found that the human parathyroid hormone-related peptide (hPTHrP) gene contained a DNA element (nVDREhPTHrP) homologous to a negative vitamin D response element in the human parathyroid hormone gene.	Vitamin D	137-146	parathyroid hormone like hormone	Homo sapiens	24-59
11278818-10	2001	Thus the molecular mechanism, whereby Smad3 and VDR mediate cross-talk between the TGF-beta and vitamin D signaling pathways, requires both a VDRE and a SBE located in close proximity to the target promoter.	Vitamin D	96-105	SMAD family member 3	Homo sapiens	38-43
9556566-1	1998	We found that the human parathyroid hormone-related peptide (hPTHrP) gene contained a DNA element (nVDREhPTHrP) homologous to a negative vitamin D response element in the human parathyroid hormone gene.	Vitamin D	137-146	parathyroid hormone like hormone	Homo sapiens	61-67
9553126-0	1998	Identification of a vitamin D response element in the proximal promoter of the chicken carbonic anhydrase II gene.	Vitamin D	20-29	carbonic anhydrase 2	Gallus gallus	87-108
11295155-9	2001	Vitamin D offers a protection from genotoxic effects of Vitamin D deficiency by increasing the insulin receptor gene expression and BSP (bone sialoprotein), bone-remodeling by decreasing the osteopontin (OPN) m-RNAs, maintaining the normal epidermal structure and enamel matrix.	Vitamin D	0-9	insulin receptor	Homo sapiens	95-111
11295155-9	2001	Vitamin D offers a protection from genotoxic effects of Vitamin D deficiency by increasing the insulin receptor gene expression and BSP (bone sialoprotein), bone-remodeling by decreasing the osteopontin (OPN) m-RNAs, maintaining the normal epidermal structure and enamel matrix.	Vitamin D	56-65	insulin receptor	Homo sapiens	95-111
9553126-7	1998	Mutations provided evidence that the 1, 25-(OH)2D3-mediated activation of the carbonic anhydrase II gene is mediated by VDR.RXR heterodimers bound to a DR3-type vitamin D response element with sequence AGGGCAtggAGTTCG.	Vitamin D	161-170	carbonic anhydrase 2	Gallus gallus	78-99
11231338-5	2001	Recently, NaSi-1 was shown to be regulated at the protein and mRNA level by a number of factors, such as vitamin D, dietary sulfate, glucocorticoids and thyroid hormones, which are known to modulate sulfate reabsorption in vivo.	Vitamin D	105-114	solute carrier family 13 member 1	Homo sapiens	10-16
9553126-7	1998	Mutations provided evidence that the 1, 25-(OH)2D3-mediated activation of the carbonic anhydrase II gene is mediated by VDR.RXR heterodimers bound to a DR3-type vitamin D response element with sequence AGGGCAtggAGTTCG.	Vitamin D	161-170	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	120-123
9541123-7	1998	At 41 degrees C, gp330/megalin mRNA expression was significantly increased compared with cells incubated at 34 degrees C. CONCLUSION: The results indicate a correlation between exposure to retinoic acid or vitamin D or induction of cell differentiation (by retinoic acid/cAMP in F9 cells or inhibition of SV40 transcription in IRPTCs) and an increase in gp330/megalin protein and mRNA expression.	Vitamin D	206-215	LDL receptor related protein 2	Homo sapiens	17-22
11311530-10	2001	Gel shift analyses evaluated with the murine osteopontin vitamin D response element indicated a specific, bound receptor-containing complex from hippocampal extracts.	Vitamin D	57-66	secreted phosphoprotein 1	Mus musculus	45-56
9541123-7	1998	At 41 degrees C, gp330/megalin mRNA expression was significantly increased compared with cells incubated at 34 degrees C. CONCLUSION: The results indicate a correlation between exposure to retinoic acid or vitamin D or induction of cell differentiation (by retinoic acid/cAMP in F9 cells or inhibition of SV40 transcription in IRPTCs) and an increase in gp330/megalin protein and mRNA expression.	Vitamin D	206-215	LDL receptor related protein 2	Homo sapiens	23-30
9541123-7	1998	At 41 degrees C, gp330/megalin mRNA expression was significantly increased compared with cells incubated at 34 degrees C. CONCLUSION: The results indicate a correlation between exposure to retinoic acid or vitamin D or induction of cell differentiation (by retinoic acid/cAMP in F9 cells or inhibition of SV40 transcription in IRPTCs) and an increase in gp330/megalin protein and mRNA expression.	Vitamin D	206-215	LDL receptor related protein 2	Homo sapiens	354-359
9541123-7	1998	At 41 degrees C, gp330/megalin mRNA expression was significantly increased compared with cells incubated at 34 degrees C. CONCLUSION: The results indicate a correlation between exposure to retinoic acid or vitamin D or induction of cell differentiation (by retinoic acid/cAMP in F9 cells or inhibition of SV40 transcription in IRPTCs) and an increase in gp330/megalin protein and mRNA expression.	Vitamin D	206-215	LDL receptor related protein 2	Homo sapiens	360-367
9792954-14	1998	These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene.	Vitamin D	220-229	parathyroid hormone like hormone	Homo sapiens	56-61
9792954-14	1998	These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene.	Vitamin D	220-229	parathyroid hormone like hormone	Homo sapiens	187-192
9337080-4	1997	Following 96-hr treatment of U937 and HL-60 cells with 5 x 10(-10) M of the vitamin D derivatives, a striking increase in CD14 antigen expression was apparent, indicating the promotion by these compounds of a monocyte/macrophage lineage of cells.	Vitamin D	76-85	CD14 molecule	Homo sapiens	122-126
9337080-11	1997	However, analysis of CD14 revealed a dramatic diminution in HL-60 cells treated with the combinations of the vitamin D derivatives and the retinoids.	Vitamin D	109-118	CD14 molecule	Homo sapiens	21-25
9213220-4	1997	Interestingly, the simultaneous expression of the native vitamin D receptor and the retinoid X receptor beta resulted in a ligand independent transactivation of the lacZ reporter gene coupled to a mouse osteopontin vitamin D response element.	Vitamin D	57-66	secreted phosphoprotein 1	Mus musculus	203-214
9213220-6	1997	Furthermore, transactivating activity of a Gal4-fused vitamin D receptor was induced by vitamin D in a one-hybrid system devoid of retinoid X receptors.	Vitamin D	54-63	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	43-47
9226545-1	1997	The monoglucuronides of vitamin D, 25-hydroxyvitamin D and the corresponding pro-forms were subjected to enzymatic hydrolysis using beta-glucuronidase, and substrate specificities were found in the examined enzymes originating from different sources, which were determined using reversed-phase high-performance liquid chromatography with UV detection.	Vitamin D	24-33	glucuronidase beta	Homo sapiens	132-150
9108352-9	1997	Overexpression of HES-1 suppressed the vitamin D-dependent upregulation of osteopontin gene expression in these cells.	Vitamin D	39-48	secreted phosphoprotein 1	Rattus norvegicus	75-86
9099905-0	1997	The noncalcemic vitamin D analogues EB1089 and 22-oxacalcitriol interact with the vitamin D receptor and suppress parathyroid hormone-related peptide gene expression.	Vitamin D	16-25	parathyroid hormone like hormone	Homo sapiens	114-149
9225109-2	1997	Previously, it has been shown that vitamin D status affects chick kidney PKI activity: a 5- to 10-fold increase in PKI activity was observed in kidneys of chronically vitamin D-deficient chicks and treatment with 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) in cultured kidney cells resulted in a 95% decrease in PKI activity.	Vitamin D	35-44	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	73-76
9225109-2	1997	Previously, it has been shown that vitamin D status affects chick kidney PKI activity: a 5- to 10-fold increase in PKI activity was observed in kidneys of chronically vitamin D-deficient chicks and treatment with 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) in cultured kidney cells resulted in a 95% decrease in PKI activity.	Vitamin D	35-44	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	115-118
9225109-2	1997	Previously, it has been shown that vitamin D status affects chick kidney PKI activity: a 5- to 10-fold increase in PKI activity was observed in kidneys of chronically vitamin D-deficient chicks and treatment with 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) in cultured kidney cells resulted in a 95% decrease in PKI activity.	Vitamin D	167-176	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	73-76
9225109-2	1997	Previously, it has been shown that vitamin D status affects chick kidney PKI activity: a 5- to 10-fold increase in PKI activity was observed in kidneys of chronically vitamin D-deficient chicks and treatment with 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) in cultured kidney cells resulted in a 95% decrease in PKI activity.	Vitamin D	167-176	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	115-118
9225109-6	1997	PKI mRNA steady-state levels are downregulated by 47% in kidneys from vitamin D-replete chicks as compared to vitamin D-deficient chicks.	Vitamin D	70-79	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	0-3
9225109-6	1997	PKI mRNA steady-state levels are downregulated by 47% in kidneys from vitamin D-replete chicks as compared to vitamin D-deficient chicks.	Vitamin D	110-119	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	0-3
9392437-1	1997	The human mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily, which includes receptors for retinoic acid, vitamin D, and other steroids, such as the glucocorticoids (which bind the glucocorticoid receptor, GR).	Vitamin D	151-160	nuclear receptor subfamily 3 group C member 2	Homo sapiens	10-36
9392437-1	1997	The human mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily, which includes receptors for retinoic acid, vitamin D, and other steroids, such as the glucocorticoids (which bind the glucocorticoid receptor, GR).	Vitamin D	151-160	nuclear receptor subfamily 3 group C member 2	Homo sapiens	38-40
8923469-0	1996	Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.	Vitamin D	26-35	secreted phosphoprotein 1	Rattus norvegicus	186-197
8806764-1	1996	Vitamin D binding protein (DBP) plays an essential role in the vitamin D hormone endocrine system in sequestering vitamin D3 and its metabolites with high affinity, and transporting them to various target organs and tissues.	Vitamin D	63-72	GC, vitamin D binding protein	Rattus norvegicus	0-25
7592714-11	1995	Calcium depletion of the medium blunted the IGF-I effect but not that of human 1-34 parathyroid hormone 5 x 10(-8) M. IGF-I thus appears to be the first example of a physiological calcium-dependent regulator of the renal metabolism of vitamin D.	Vitamin D	235-244	insulin-like growth factor 1	Mus musculus	118-123
21153172-0	1995	Pharmacokinetic studies of vitamin D analogues: relationship to vitamin D binding protein (DBP).	Vitamin D	27-36	GC, vitamin D binding protein	Rattus norvegicus	64-89
7798277-0	1994	Evidence for the uptake of a vitamin D analogue (OCT) by a human carcinoma and its effect of suppressing the transcription of parathyroid hormone-related peptide gene in vivo.	Vitamin D	29-38	parathyroid hormone like hormone	Homo sapiens	126-161
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Vitamin D	69-78	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	130-148
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Vitamin D	69-78	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	150-153
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Vitamin D	69-78	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	159-162
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Vitamin D	38-47	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	127-145
8089147-2	1994	This report describes purification of a receptor for 1 alpha,25-(OH)2D3 (VDR) located in the basal-lateral membrane (BLM) of vitamin D-replete chick intestinal epithelium, which is implicated in the nongenomic stimulation of calcium transport (transcaltachia).	Vitamin D	125-134	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	73-76
10609555-6	2000	The expression of the three vitamin D-regulated genes calbindin-D28k, 1,25-dihydroxyvitamin D3-24-hydroxylase (24-OHase), and vitamin D receptor (VDR) were quantified in rat kidney homogenates by real-time reverse transcription-polymerase chain reaction.	Vitamin D	28-37	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	111-119
10620374-2	2000	In the present investigation we probed the vitamin D sterol-binding pocket of human DBP with affinity labeling analogs of 25-hydroxyvitamin D(3) ?25-OH-D(3) and 1, 25-dihydroxyvitamin D(3) ?1,25(OH)(2)D(3) containing bromoacetate alkylating probe at C-3 (A-ring), C-6 (triene), C-11 (C-ring), and C-19 (exocyclic methylene) of the parent sterol.	Vitamin D	43-52	complement C6	Homo sapiens	264-267
10438498-8	1999	Furthermore, with stably transfected cell lines, we demonstrate that the C/EBP binding site in the CD14 promoter plays a critical role for mediating TGF-beta signaling in the synergistic activation of CD14 expression by vitamin D(3) and TGF-beta during U937 differentiation.	Vitamin D	220-229	CD14 molecule	Homo sapiens	99-103
10438498-8	1999	Furthermore, with stably transfected cell lines, we demonstrate that the C/EBP binding site in the CD14 promoter plays a critical role for mediating TGF-beta signaling in the synergistic activation of CD14 expression by vitamin D(3) and TGF-beta during U937 differentiation.	Vitamin D	220-229	CD14 molecule	Homo sapiens	201-205
10417310-8	1999	We show in gel-shift assays that the sequence within a putative vitamin-D-response element in the human calbindin-D9k promoter can bind expressed IPF-1/PDX-1 protein, although we cannot confirm binding of the vitamin-D-receptor protein.	Vitamin D	64-73	pancreatic and duodenal homeobox 1	Homo sapiens	146-151
10406465-9	1999	Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor.	Vitamin D	168-177	nuclear receptor coactivator 1	Homo sapiens	40-78
10406465-9	1999	Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor.	Vitamin D	168-177	nuclear receptor coactivator 1	Homo sapiens	80-85
10224118-6	1999	As a consequence, overexpression of steroid receptor coactivator-1 increased vitamin D-dependent transactivation by VDR but not by the K246A mutant.	Vitamin D	77-86	nuclear receptor coactivator 1	Homo sapiens	36-66
9916136-6	1999	Peak steady-state mRNA levels of the vitamin D-dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP-/- mice.	Vitamin D	37-46	S100 calcium binding protein G	Mus musculus	57-70
9492037-0	1998	The noncalcemic vitamin D analogs EB1089 and 22-oxacalcitriol suppress serum-induced parathyroid hormone-related peptide gene expression in a lung cancer cell line.	Vitamin D	16-25	parathyroid hormone like hormone	Homo sapiens	85-120
9541123-4	1998	Similarly, an increase in gp330/megalin mRNA expression was seen in JEG-3 cells cultured with vitamin D and retinoids, as well as when F9 cells were differentiated by incubation with retinoic acid and cAMP.	Vitamin D	94-103	LDL receptor related protein 2	Homo sapiens	26-31
9541123-4	1998	Similarly, an increase in gp330/megalin mRNA expression was seen in JEG-3 cells cultured with vitamin D and retinoids, as well as when F9 cells were differentiated by incubation with retinoic acid and cAMP.	Vitamin D	94-103	LDL receptor related protein 2	Homo sapiens	32-39
9337080-8	1997	Treatment of U937 cell cultures with the vitamin D compounds and the retinoids resulted in cooperative effects on induction of differentiation, with correlation by both NBT reduction and FACS analyses of CD14 antigen expression.	Vitamin D	41-50	CD14 molecule	Homo sapiens	204-208
9204985-5	1997	Fluorescence activated cell scanning (FACS) analyses indicated that the vitamin D derivatives readily induced the expression of the monocyte-associated cell surface antigen, CD14, and also the beta2-integrins, CD11b and CD18 in both cell lines after 48 h and 96 h treatment.	Vitamin D	72-81	CD14 molecule	Homo sapiens	174-178
9204985-7	1997	When U937 and HL-60 cell cultures were cotreated for 48 h with the vitamin D compounds and GM-CSF and analysed by FACS, enhanced effects on CD14 and CD11b induction were observed compared to those of the compounds alone.	Vitamin D	67-76	CD14 molecule	Homo sapiens	140-144
8940000-0	1996	Functional assessment of two vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase gene.	Vitamin D	29-38	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	70-105
8939905-0	1996	Transcriptional synergism between vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) promoter.	Vitamin D	34-43	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	75-110
8939905-0	1996	Transcriptional synergism between vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) promoter.	Vitamin D	34-43	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	112-117
8939905-2	1996	The functional activities of three possible vitamin D response elements (VDREs), located on the antisense strand of the rat CYP24 promoter, were investigated by transient expression of native and mutant promoter constructs in COS-1, JTC-12, and ROS 17/2.8 cells.	Vitamin D	44-53	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	124-129
8933375-0	1996	Differential expression of M-CSF, LIF, and TNF-alpha genes in normal and malignant rat glial cells: regulation by lipopolysaccharide and vitamin D.	Vitamin D	137-146	colony stimulating factor 1	Rattus norvegicus	27-32
8900396-1	1996	The binding of the 1,25-dihydroxyvitamin D3 receptor to the vitamin D response elements (VDREs) in the rat osteocalcin (OSC-DRE), mouse osteopontin (MOP-DRE), rat calbindin D-9k (CaBP-DRE), and human parathyroid hormone genes (PTH-DRE) was studied.	Vitamin D	33-42	secreted phosphoprotein 1	Mus musculus	136-147
8766903-3	1996	Calcitriol, the active metabolite of vitamin D, induces the synthesis of calbindin, a Ca(2+)-binding protein which seems to be involved in transcellular Ca(2+)-transport, increases the number of Ca(2+)-transport components in the apical membrane, but is without direct influence on Ca(2+)-pumps of the basolateral membrane.	Vitamin D	37-46	calbindin 1	Sus scrofa	73-82
18406732-5	1996	In addition, regulatory studies of the TRH gene by T(3) should be relevant to other hormone receptor interactions with DNA sequences in general, as glucocorticoids, mineralocorticoids, sex steroids, vitamin D, and retinoic acid are ligands for homologous receptor proteins in the nuclear receptor superfamily.	Vitamin D	199-208	thyrotropin releasing hormone	Homo sapiens	39-42
9011759-0	1996	Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells.	Vitamin D	0-9	tyrosine hydroxylase	Mus musculus	38-58
8524311-0	1996	Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid.	Vitamin D	0-9	gonadotropin releasing hormone receptor	Rattus norvegicus	49-63
8524311-2	1996	Incubation of pituitary GH4C1 cells with nanomolar concentrations of vitamin D markedly reduces the response of the rat growth hormone mRNA to thyroid hormone triiodothyronine (T3) and RA.	Vitamin D	69-78	gonadotropin releasing hormone receptor	Rattus norvegicus	120-134
8785878-21	1995	If a genetic defect decreases the affinity of a suppressive receptor/ligand complex for the regulatory element of IL-6 or TGF-alpha, for example, then these cells could be relatively resistant to homeostatic regulation by indigenous corticosteroids, vitamin D, and retinoids.	Vitamin D	250-259	transforming growth factor alpha	Homo sapiens	122-131
7730337-7	1995	The expression of a Ng/RC3-luciferase fusion construct (-1508/+256) in transfected 293 cells was stimulated by phorbol 12-myristate 13-acetate (PMA), but not by cAMP, arachidonic acid, vitamin D, retinoic acid, or thyroxines T3 and T4.	Vitamin D	185-194	neurogranin	Homo sapiens	23-26
7923831-1	1994	OBJECTIVE: Parathyroid hormone-related protein (PTHrP) is recognized as a major pathogenetic factor of humoral hypercalcaemia of malignancy but its action on vitamin D metabolism is controversial.	Vitamin D	158-167	parathyroid hormone like hormone	Homo sapiens	11-46
7923831-1	1994	OBJECTIVE: Parathyroid hormone-related protein (PTHrP) is recognized as a major pathogenetic factor of humoral hypercalcaemia of malignancy but its action on vitamin D metabolism is controversial.	Vitamin D	158-167	parathyroid hormone like hormone	Homo sapiens	48-53
8089197-3	1994	This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter.	Vitamin D	156-165	immunoglobulin kappa variable 1-5	Homo sapiens	209-218
8089197-3	1994	This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter.	Vitamin D	226-235	immunoglobulin kappa variable 1-5	Homo sapiens	209-218
8089197-5	1994	Pore size exclusion and sedimentation velocity analyses suggest that the V1 and V2 complexes represent oligomeric protein assemblies (respectively, tetramers and trimers), and reflect primarily DNA-directed association of the monomeric protein components at the osteocalcin Vitamin D responsive element.	Vitamin D	274-283	immunoglobulin kappa variable 1-5	Homo sapiens	73-82
8089197-6	1994	UV crosslinking and methylation interference analyses of the V1 and V2 complexes at the osteocalcin Vitamin D responsive element indicate differences in protein/DNA recognition.	Vitamin D	100-109	immunoglobulin kappa variable 1-5	Homo sapiens	61-70
8089197-8	1994	Our findings suggest variations in protein/protein and protein/DNA interactions of the VDR and RXR related complexes V1 and V2 at the osteocalcin Vitamin D responsive element that reflect unique properties of the osteosarcoma and normal diploid osteoblast phenotype.	Vitamin D	146-155	immunoglobulin kappa variable 1-5	Homo sapiens	117-126
8389284-5	1993	Vitamin D treatment when combined with a high level of dietary calcium resulted in an increase in plasma calcium from 6 mg/dl to greater than 10 mg/dl, a decrease in PTH mRNA of 65%, and a 6- to 8-fold increase in VDR mRNA.	Vitamin D	0-9	parathyroid hormone	Gallus gallus	166-169
8179318-2	1994	The purified receptor is homogeneous, and is bound by 1,25-dihydroxyvitamin D3 with a Kd of 5 x 10(-10) M. The isolated receptor binds to the osteocalcin vitamin D response element in the presence of porcine intestinal nuclear extract stripped of endogenous vitamin D receptor as well.	Vitamin D	68-77	vitamin D receptor	Rattus norvegicus	258-276
8415688-3	1993	An electrophoretic mobility-shift analysis demonstrated that VDR, derived from extracts of the small intestines of vitamin D-deficient rats, is capable of binding a vitamin D response element (DRE).	Vitamin D	115-124	vitamin D receptor	Rattus norvegicus	61-64
8415688-3	1993	An electrophoretic mobility-shift analysis demonstrated that VDR, derived from extracts of the small intestines of vitamin D-deficient rats, is capable of binding a vitamin D response element (DRE).	Vitamin D	165-174	vitamin D receptor	Rattus norvegicus	61-64
7690968-8	1993	We conclude that CYP27 is capable of 24-, 25-, and 26(27)-hydroxylation of vitamin D analogs and that the nature of products is partially dictated by the side chain of the substrate.	Vitamin D	75-84	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	17-22
7690968-9	1993	This work has revealed that the cytochrome P-450 CYP27 may be important in the metabolism of vitamin D analogs used as drugs.	Vitamin D	93-102	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	49-54
8394128-6	1993	Transient transfection of osteosarcoma cells with a reporter vector containing a vitamin D responsive element derived from the rat osteocalcin gene yields equivalent transcriptional activation in the presence of either 1,25(OH)2D3 or OCT. Further experiments performed at various 1,25(OH)2D3 concentrations to assess the relationship between receptor phosphorylation and transcriptional activity in intact cells showed a positive correlation between these two parameters, indicating that the 1,25(OH)2D3 hormone stimulates VDR phosphorylation and transcriptional activation in parallel.	Vitamin D	81-90	vitamin D receptor	Rattus norvegicus	523-526
8254580-2	1993	The vitamin D receptor requires an accessory protein for binding to the vitamin D responsive element (VDRE) in the osteocalcin gene.	Vitamin D	4-13	bone gamma-carboxyglutamate protein 2	Mus musculus	115-126
8385999-7	1993	Thus, dietary calcium is required for vitamin D to up-regulate the renal vitamin D receptor level.	Vitamin D	38-47	vitamin D receptor	Rattus norvegicus	73-91
1466160-4	1992	The concentrations of two vitamin D-dependent calcium-binding proteins were also decreased: a low duodenal calbindin-D 9K concentration corresponding to the low intestinal active calcium absorption and a low serum osteocalcin concentration, corresponding to a low bone formation and highly correlated with serum IGF-I concentration.	Vitamin D	26-35	S100 calcium binding protein G	Rattus norvegicus	107-121
1466160-4	1992	The concentrations of two vitamin D-dependent calcium-binding proteins were also decreased: a low duodenal calbindin-D 9K concentration corresponding to the low intestinal active calcium absorption and a low serum osteocalcin concentration, corresponding to a low bone formation and highly correlated with serum IGF-I concentration.	Vitamin D	26-35	insulin-like growth factor 1	Rattus norvegicus	312-317
7679502-0	1993	Vitamin D and adaptation to dietary calcium and phosphate deficiencies increase intestinal plasma membrane calcium pump gene expression.	Vitamin D	0-9	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	91-119
1655516-3	1991	Changes of ANF tissue and blood levels under dietary deficiency and treatment with 1,25-D3 suggest direct genomic actions of vitamin D on myoendocrine cells of the atrium for the regulation of ANF manufacture and secretion.	Vitamin D	125-134	natriuretic peptide type A	Mus musculus	193-196
7679502-1	1993	The effect of vitamin D and other variables on the synthesis of the chicken intestinal plasma membrane calcium pump (PMCA) mRNA was assessed.	Vitamin D	14-23	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	87-115
2019796-4	1991	We have investigated the effect of 1,25,(OH)2D3 on mesangial cell growth and found that this vitamin D metabolite suppresses the proliferation of mouse mesangial cells as assessed by mesangial cell tritiated thymidine uptake and by cell counts; this substance also antagonizes the mitogenic effect of epidermal growth factor on mesangial cell growth.	Vitamin D	93-102	epidermal growth factor	Mus musculus	301-324
7679502-1	1993	The effect of vitamin D and other variables on the synthesis of the chicken intestinal plasma membrane calcium pump (PMCA) mRNA was assessed.	Vitamin D	14-23	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	117-121
7679502-6	1993	Northern analysis with the chicken PMCA DNA indicated that repletion of vitamin D-deficient chickens with vitamin D increased PMCA mRNAs in the duodenum, jejunum, ileum, and colon.	Vitamin D	72-81	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	35-39
7679502-6	1993	Northern analysis with the chicken PMCA DNA indicated that repletion of vitamin D-deficient chickens with vitamin D increased PMCA mRNAs in the duodenum, jejunum, ileum, and colon.	Vitamin D	72-81	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	126-130
7679502-6	1993	Northern analysis with the chicken PMCA DNA indicated that repletion of vitamin D-deficient chickens with vitamin D increased PMCA mRNAs in the duodenum, jejunum, ileum, and colon.	Vitamin D	106-115	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	35-39
7679502-6	1993	Northern analysis with the chicken PMCA DNA indicated that repletion of vitamin D-deficient chickens with vitamin D increased PMCA mRNAs in the duodenum, jejunum, ileum, and colon.	Vitamin D	106-115	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	126-130
2251793-5	1990	Thus, the effects of T-2 toxin on the vitamin D-dependent endocrine system were manifested as development of the vitamin, secondary deficiency, as resistance of I-hydroxylase 25OHD3 to regulating effect of parath hormone as well as inhibition of interaction between the complexes 1,25(OH)2D3-receptor and chromatin.	Vitamin D	38-47	brachyury 2	Rattus norvegicus	21-24
33237074-9	2020	Vitamin D deficiency also lowered the placental protein levels of pro-angiogenic proteins VEGF and Flt-1 (p < 0.05 and p < 0.01, respectively), while the levels of these proteins in the VDS-PE group were similar to those in the control group.	Vitamin D	0-9	vascular endothelial growth factor A	Rattus norvegicus	90-94
33237074-11	2020	CONCLUSION: A low dose vitamin D supplementation given from pre-pregnancy and throughout pregnancy was beneficial in reducing the blood pressure and normalizing the placental levels of VEGF and Flt-1.	Vitamin D	23-32	vascular endothelial growth factor A	Rattus norvegicus	185-189
7679502-7	1993	After injection of 1,25-dihydroxyvitamin D3 intravenously into vitamin D-deficient chickens, duodenal PMCA mRNA tended to increase by 2 hr, reached a maximum at about 16 hr, and returned to baseline levels at 48 hr.	Vitamin D	33-42	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	102-106
7679502-9	1993	These results indicate that vitamin D and specific variables that affect calcium absorption through the vitamin D-endocrine system increase intestinal PMCA gene expression.	Vitamin D	28-37	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	151-155
24943330-0	2014	Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease.	Vitamin D	0-9	heart and neural crest derivatives expressed 2	Mus musculus	29-32
7679502-9	1993	These results indicate that vitamin D and specific variables that affect calcium absorption through the vitamin D-endocrine system increase intestinal PMCA gene expression.	Vitamin D	104-113	ATPase plasma membrane Ca2+ transporting 1	Gallus gallus	151-155
24943330-9	2014	CONCLUSION: Peri-natal vitamin D deficiency alone has immunomodulatory effects including Th2 skewing and reduced IL-10-secreting T regulatory cells, exaggerated with additional allergen exposure.	Vitamin D	23-32	heart and neural crest derivatives expressed 2	Mus musculus	89-92
1321435-3	1992	In addition, a vitamin D-responsive increase in OC gene transcription is accompanied by enhanced non-vitamin D receptor-mediated protein-DNA interactions in the "TATA" box region (nucleotides -44 to +23), which also contains a potential glucocorticoid responsive element.	Vitamin D	15-24	vitamin D receptor	Rattus norvegicus	101-119
1542030-3	1992	However, in the vitamin D-replete rat, administration of 1,25(OH)2D3 results in an induction of both calbindin and VDR mRNA in these tissues.	Vitamin D	16-25	vitamin D receptor	Rattus norvegicus	115-118
34352263-7	2022	Importantly, vitamin D and acitretin partly restored the PAD1 defect caused by IL-22.	Vitamin D	13-22	peptidyl arginine deiminase 1	Homo sapiens	57-61
1584219-7	1992	In cerebellum, the same set of DH sites was observed in the presence or absence of 1,25-(OH)2D3 treatment, reflecting the vitamin D-independent expression of the calbindin gene in this tissue.	Vitamin D	122-131	calbindin 1	Homo sapiens	162-171
34953963-2	2022	Our previous studies revealed that vitamin D deficiency promotes beta-amyloid (Abeta) deposition in the APP/PS1 mouse brains, while supplemented with a specific agonist of vitamin D receptor (VDR), paricalcitol (PAL), significantly reduced Abeta production via promoting the lysosomal degradation of beta-site APP cleavage enzyme 1 (BACE1).	Vitamin D	35-44	amyloid beta (A4) precursor protein	Mus musculus	79-84
34953963-2	2022	Our previous studies revealed that vitamin D deficiency promotes beta-amyloid (Abeta) deposition in the APP/PS1 mouse brains, while supplemented with a specific agonist of vitamin D receptor (VDR), paricalcitol (PAL), significantly reduced Abeta production via promoting the lysosomal degradation of beta-site APP cleavage enzyme 1 (BACE1).	Vitamin D	35-44	presenilin 1	Mus musculus	108-111
34953963-2	2022	Our previous studies revealed that vitamin D deficiency promotes beta-amyloid (Abeta) deposition in the APP/PS1 mouse brains, while supplemented with a specific agonist of vitamin D receptor (VDR), paricalcitol (PAL), significantly reduced Abeta production via promoting the lysosomal degradation of beta-site APP cleavage enzyme 1 (BACE1).	Vitamin D	35-44	amyloid beta (A4) precursor protein	Mus musculus	240-245
34953963-2	2022	Our previous studies revealed that vitamin D deficiency promotes beta-amyloid (Abeta) deposition in the APP/PS1 mouse brains, while supplemented with a specific agonist of vitamin D receptor (VDR), paricalcitol (PAL), significantly reduced Abeta production via promoting the lysosomal degradation of beta-site APP cleavage enzyme 1 (BACE1).	Vitamin D	35-44	beta-site APP cleaving enzyme 1	Mus musculus	333-338
34657267-0	2022	Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model.	Vitamin D	10-19	TNF receptor superfamily member 11B	Rattus norvegicus	39-42
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interleukin 1 alpha	Homo sapiens	119-127
34944511-0	2021	New Variants of the Cytochrome P450 2R1 (CYP2R1) Gene in Individuals with Severe Vitamin D-Activating Enzyme 25(OH)D Deficiency.	Vitamin D	81-90	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	20-39
1312945-1	1992	Purified porcine erythrocyte membrane Ca(2+)-ATPase and 3":5"-cyclic nucleotide phosphodiesterase were stimulated in a dose-dependent, saturable manner with the vitamin D-dependent calcium binding protein from rat kidney, calbindin-D28k (CaBP-D28k).	Vitamin D	161-170	S100 calcium binding protein G	Rattus norvegicus	238-242
34944511-0	2021	New Variants of the Cytochrome P450 2R1 (CYP2R1) Gene in Individuals with Severe Vitamin D-Activating Enzyme 25(OH)D Deficiency.	Vitamin D	81-90	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	41-47
34944511-2	2021	Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D).	Vitamin D	96-105	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-19
34944511-2	2021	Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D).	Vitamin D	96-105	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	21-27
34944511-2	2021	Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D).	Vitamin D	96-105	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	44-50
34944511-4	2021	We performed Sanger sequencing of three selected fragments of the CYP2R1 gene (Ch11: 14878000-14878499; Ch11: 14880058-14880883 and Ch11: 14885321-14886113) that affect the binding of substrates to this enzyme and analyzed the possible involvement of genetic variation in these regions with an increased risk of vitamin D deficiency in healthy Polish individuals.	Vitamin D	312-321	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	66-72
1869447-1	1991	This electron microscope study describes the subcellular occurrence and distribution of immunoreactive calbindin-D9K in the trabecular metaphyseal and compact cortical bone of normal rats, rachitic vitamin-D-deficient rats, and rachitic rats given 1,25-(OH)2D3.	Vitamin D	198-207	S100 calcium binding protein G	Rattus norvegicus	103-116
34536747-0	2021	Role of vitamin D/VDR nuclear translocation in down-regulation of NF-kappaB/NLRP3/caspase-1 axis in lupus nephritis.	Vitamin D	8-17	NLR family, pyrin domain containing 3	Mus musculus	76-81
34453946-0	2021	zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D.	Vitamin D	123-132	zinc finger, MIZ-type containing 1a	Danio rerio	0-6
34453946-9	2021	Finally, we showed that the loss of Zmiz1a decreased the capacity of the embryos to respond to vitamin D, indicating additional participation of Zmiz1a as a mediator of vitamin D activity.	Vitamin D	95-104	zinc finger, MIZ-type containing 1a	Danio rerio	36-42
34453946-9	2021	Finally, we showed that the loss of Zmiz1a decreased the capacity of the embryos to respond to vitamin D, indicating additional participation of Zmiz1a as a mediator of vitamin D activity.	Vitamin D	95-104	zinc finger, MIZ-type containing 1a	Danio rerio	145-151
34453946-9	2021	Finally, we showed that the loss of Zmiz1a decreased the capacity of the embryos to respond to vitamin D, indicating additional participation of Zmiz1a as a mediator of vitamin D activity.	Vitamin D	169-178	zinc finger, MIZ-type containing 1a	Danio rerio	145-151
2305880-2	1990	Vitamin D metabolites, serum calcium and phosphorus levels, and the developmental appearance of vitamin D-dependent intestinal calcium binding protein (calbindin-D9k) was studied in normal and mutant rats of tl stock from 7 to 35 days of age.	Vitamin D	96-105	S100 calcium binding protein G	Rattus norvegicus	152-165
34197883-6	2021	Thus, in addition to their classical antioxidative properties usually associated with mitochondrial effects, it is known that MEL and vitamin D modulate the expression and activity of Cu/Zn-dependent SOD isoforms, MTs and CP; function as copper chelators and regulate genomic and non-genomic mechanisms related to the zinc transport.	Vitamin D	134-143	ceruloplasmin	Homo sapiens	222-224
33771629-0	2021	PARACOCCIDIOIDES brasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro.	Vitamin D	77-86	interleukin 32	Homo sapiens	38-43
34274437-8	2021	The aggravation of cerebral ischemia caused by vitamin D deficiency is possibly due to up-regulating GRP78 and down-regulating CHOP in brain tissue.	Vitamin D	47-56	DNA-damage inducible transcript 3	Rattus norvegicus	127-131
34279814-1	2022	The genetic background and vitamin D supplementation can affect irisin levels in Prader-Willi syndrome.	Vitamin D	27-36	fibronectin type III domain containing 5	Homo sapiens	64-70
34474718-10	2021	There was a negative relationship between the levels of vitamin D and the severity of asthma (Kendall tau = -0.146; p < 0.001).	Vitamin D	56-65	microtubule associated protein tau	Homo sapiens	102-105
34906413-7	2022	The associations of CYP2R1 polymorphisms and risks of vitamin D deficiency (VDD) were analyzed by logistic regression.	Vitamin D	54-63	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	20-26
34242778-17	2021	The prevalence of vitamin D deficiency (VDD) was 35.8% at V1 and 32.4% at V2.	Vitamin D	18-27	nibrin	Homo sapiens	71-76
34919352-1	2022	BACKGROUND: Many studies in dairy cows are towards calcium homeostasis and there is a lack of knowledge about the effect of vitamin D in preventing insulin resistance and improving energy balance in the transition period of dairy cows.	Vitamin D	124-133	insulin	Bos taurus	148-155
34062067-10	2021	LMF1 concentration correlated positively with vitamin D level in dialyzed patients.	Vitamin D	46-55	lipase maturation factor 1	Homo sapiens	0-4
34460994-15	2021	Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level.	Vitamin D	153-162	forkhead box P3	Mus musculus	74-80
34460994-15	2021	Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level.	Vitamin D	153-162	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	224-227
34454533-1	2021	BACKGROUND: This study aimed to examine the effect of yoga training combined with vitamin D supplementation on the expression of survival-related genes in leukocytes and psycho-physical status in breast cancer survivors.	Vitamin D	82-91	castor zinc finger 1	Homo sapiens	129-145
34851599-3	2021	In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma).	Vitamin D	33-42	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	71-78
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	98-107	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	33-36
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	98-107	beclin 1, autophagy related	Mus musculus	38-46
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	98-107	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	72-75
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	165-174	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	33-36
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	165-174	beclin 1, autophagy related	Mus musculus	38-46
34466017-8	2021	The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group.	Vitamin D	165-174	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	72-75
34615940-9	2021	Children with BA have impaired vitamin D activation due to CYP2R1 deficiency.	Vitamin D	31-40	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	59-65
34484304-0	2021	Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.	Vitamin D	24-33	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	47-53
34583869-2	2021	The disease is caused principally by PHEX mutations leading to increased concentrations of circulating intact FGF23, hence renal phosphate wasting, hypophosphatemia, and decreased circulating levels of 1,25(OH)2 vitamin D.	Vitamin D	212-221	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	37-41
34484304-2	2021	Objective: This study aims to investigate whether 11 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (CYP2R1, CYP24A1, and CYP27B1) are associated with the risk of NAFLD.	Vitamin D	105-114	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	142-148
34154571-8	2021	CONCLUSION: In conclusion, the results of the current study support a possible favorable effect of vitamin D on increase AMH expression by acting on the AMH gene promoter.	Vitamin D	99-108	anti-Mullerian hormone	Homo sapiens	121-124
34154571-8	2021	CONCLUSION: In conclusion, the results of the current study support a possible favorable effect of vitamin D on increase AMH expression by acting on the AMH gene promoter.	Vitamin D	99-108	anti-Mullerian hormone	Homo sapiens	153-156
34154571-9	2021	Therefore, it is possible that vitamin D increases AMH levels without changing the antral follicle count/ovarian reserve.	Vitamin D	31-40	anti-Mullerian hormone	Homo sapiens	51-54
34207794-0	2021	Vitamin D Supplementation Regulates Postoperative Serum Levels of PD-L1 in Patients with Digestive Tract Cancer and Improves Survivals in the Highest Quintile of PD-L1: A Post Hoc Analysis of the AMATERASU Randomized Controlled Trial.	Vitamin D	0-9	CD274 molecule	Homo sapiens	66-71
34207794-1	2021	Because vitamin D responsive elements have been found to be located in the PD-L1 gene, vitamin D supplementation was hypothesized to regulate serum PD-L1 levels and thus alter survival time of cancer patients.	Vitamin D	8-17	CD274 molecule	Homo sapiens	75-80
34207794-1	2021	Because vitamin D responsive elements have been found to be located in the PD-L1 gene, vitamin D supplementation was hypothesized to regulate serum PD-L1 levels and thus alter survival time of cancer patients.	Vitamin D	87-96	CD274 molecule	Homo sapiens	75-80
34207794-1	2021	Because vitamin D responsive elements have been found to be located in the PD-L1 gene, vitamin D supplementation was hypothesized to regulate serum PD-L1 levels and thus alter survival time of cancer patients.	Vitamin D	87-96	CD274 molecule	Homo sapiens	148-153
34207794-5	2021	Vitamin D supplementation significantly (p = 0.0008) up-regulated serum PD-L1 levels in the lowest quintile (Q1), whereas it significantly (p = 0.0001) down-regulated them in the highest quintile (Q5), and it did not either up- or down-regulate them in the middle quintiles (Q2-Q4).	Vitamin D	0-9	CD274 molecule	Homo sapiens	72-77
34207794-6	2021	Significant effects of vitamin D supplementation, compared with placebo on death (HR, 0.34; 95% CI, 0.12-0.92) and relapse/death (HR, 0.37; 95% CI, 0.15-0.89) were observed in the highest quintile (Q5) of serum PD-L1, whereas significant effects were not observed in other quintiles (Pinteraction = 0.02 for death, Pinteraction = 0.04 for relapse/death).	Vitamin D	23-32	CD274 molecule	Homo sapiens	211-216
34207794-7	2021	Vitamin D supplementation significantly reduced the risk of relapse/death to approximately one-third in the highest quintile of serum PD-L1.	Vitamin D	0-9	CD274 molecule	Homo sapiens	134-139
34093899-0	2021	Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis.	Vitamin D	32-41	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	73-79
34093899-2	2021	DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes.	Vitamin D	43-52	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	10-16
34267439-0	2021	Relation between Vitamin D Level and Cyclin-Dependent Kinase-1 Gene Expression in Egyptian Patients with Lupus Nephritis and their Impact on Disease Activity.	Vitamin D	17-26	cyclin dependent kinase 1	Homo sapiens	37-62
34267439-3	2021	The aim of this study was to determine the relation between vitamin D level and CDK-1 in lupus nephritis patients and their impact on disease activity.	Vitamin D	60-69	cyclin dependent kinase 1	Homo sapiens	80-85
34267439-7	2021	There was a non-significant inverse correlation between vitamin D and CDK-1 (before RO-3306 addition) and a positive correlation after RO-3306.	Vitamin D	56-65	cyclin dependent kinase 1	Homo sapiens	70-75
34347981-0	2021	A Critical Review of the Therapeutic Potential of Vitamin D-Mediated Suppression of miRNA222-Associated Metabolic Defects in Polycystic Ovarian Syndrome.	Vitamin D	50-59	microRNA 222	Homo sapiens	84-92
34347981-8	2021	Thus our primary objective is to research the therapeutic efficacy of vitamin D in the suppression of miR222 and, secondary to miR222, mediated molecular pathways involving insulin resistance and metabolic defects, which influence ovarian activity, anovula-tion, and finally infertility.	Vitamin D	70-79	microRNA 222	Homo sapiens	102-108
34347981-8	2021	Thus our primary objective is to research the therapeutic efficacy of vitamin D in the suppression of miR222 and, secondary to miR222, mediated molecular pathways involving insulin resistance and metabolic defects, which influence ovarian activity, anovula-tion, and finally infertility.	Vitamin D	70-79	microRNA 222	Homo sapiens	127-133
35510742-1	2022	Purpose: Vitamin D deficiency has been linked to poorer outcomes following hip (THR) and knee (TKR) replacement.	Vitamin D	9-18	transketolase like 1	Homo sapiens	95-98
35349717-10	2022	CONCLUSIONS: Our results provide evidence that statin use may lower serum concentrations of iron, zinc, magnesium and potassium, PCSK9 inhibitors may increase serum vitamin D, and ezetimibe may increase serum calcium and retinol concentrations.	Vitamin D	165-174	proprotein convertase subtilisin/kexin type 9	Homo sapiens	129-134
35334282-5	2022	Patients with vitamin D deficiency show worse renal function reflected by postoperative glomerular filtration rate (GFR) and more release of proinflammatory cytokine IL-1beta and IL-18.	Vitamin D	14-23	interleukin 1 alpha	Homo sapiens	166-174
35413571-13	2022	Between Study Days 1 and 15, ALC-078 animals had increased concentrations of vitamin D (12.2 vs. 8.7 ng/mL, P = 0.0006), and vitamin E (4.3 vs. 2.5 mg/L, P = 0.03).	Vitamin D	77-86	allantoicase	Homo sapiens	29-32
35166042-3	2022	Given that vitamin D has been recently suggested to be protective in neurodegeneration, the aim of our study was to investigate astrocyte and neuron vitamin D pathway alterations and their correlation with alpha-Synuclein aggregates (ie, oligomers and fibrils) in human brain obtained from PD patients.	Vitamin D	149-158	synuclein alpha	Homo sapiens	206-221
35474468-0	2022	Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio).	Vitamin D	0-9	preproinsulin	Danio rerio	20-27
35403296-9	2022	After vitamin D supplementation for 90 days, T2DM patients had a 2-fold increase of GSH levels, from 2.72 +- 0.84 to 5.76 +- 3.19 mumol/ml, the concentration of MCP-1 decreased from 51.11 +- 20.86 to 25.42 +- 13.06 pg/ml, and IL-8 also decreased from 38.21 +- 21.76 to 16.05 +- 8.99 pg/ml.	Vitamin D	6-15	C-C motif chemokine ligand 2	Homo sapiens	161-166
35403296-10	2022	In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP-1 and IL-8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM.	Vitamin D	43-52	C-C motif chemokine ligand 2	Homo sapiens	128-133
35470763-7	2022	Our results demonstrated that maternal vitamin D deficiency increased anxiety and depression-related behaviors, increased levels of TNF-alpha and IL-1beta in serum, and decreased prefrontal protein expressions of BDNF and VDR in adult male offspring.	Vitamin D	39-48	vitamin D receptor	Rattus norvegicus	222-225
35470763-9	2022	CONCLUSION: It seems that developmental vitamin D deficiency disrupts brain development and has a long-lasting effect on VDR and BDNF signaling in the rat brain resulting in neuropsychiatric disorders in offspring.	Vitamin D	40-49	vitamin D receptor	Rattus norvegicus	121-124
35461467-0	2022	Induced pluripotent stem cells from homozygous Runx2-deficient mice show poor response to vitamin D during osteoblastic differentiation.	Vitamin D	90-99	runt related transcription factor 2	Mus musculus	47-52
35461467-9	2022	Insufficient response to vitamin D in Runx2-/- cells was also observed.	Vitamin D	25-34	runt related transcription factor 2	Mus musculus	38-43
34490746-11	2021	FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention.	Vitamin D	64-73	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	0-3
35157949-11	2022	CONCLUSIONS: Taken together, our results suggest that, by inhibiting the over-activation of astrocytes and increasing BDNF and neuron protection, vitamin D treatment ameliorates coal-dust-induced depressive and anxiety-like behavior, which is the first evidence that vitamin D may be a new approach for treating mood disorders caused by particulate matter.	Vitamin D	146-155	brain derived neurotrophic factor	Mus musculus	118-122
35498406-0	2022	Vitamin D Reduces Thyroid Cancer Cells Migration Independently From the Modulation of CCL2 and CXCL8 Chemokines Secretion.	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	86-90
35498406-5	2022	The aim of the present study was to investigate if vitamin D could modulate both thyroid cancer cell migration and their ability to secrete CCL2 and CXCL8.	Vitamin D	51-60	C-C motif chemokine ligand 2	Homo sapiens	140-144
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	49-53
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	110-114
35498406-11	2022	Future studies specifically designed at clarifying the pathways involved in the different inhibitory effects of vitamin D on CCL2 and CXCL8 in thyroid cancer cells appear worthwhile.	Vitamin D	112-121	C-C motif chemokine ligand 2	Homo sapiens	125-129
34680413-7	2021	We demonstrated that a combination of butyrate and active vitamin D (1 alpha, 25-dihydroxyvitamin D3) synergically reduced the severity of Salmonella colitis in C57BL/6 mice and reduced cecal inflammatory mIL-6, mIL-8, mTNF-alpha, and mIL-1beta mRNA expression, but enhanced the antimicrobial peptide mhBD-3 mRNA, compared to a single treatment.	Vitamin D	58-67	interleukin 1 alpha	Mus musculus	235-244
35401010-9	2022	It was observed that the T2DM patients with vitamin-D deficiency had significantly lower FNDC-5 mRNA expression (p=0.03) when compared with those with sufficient vitamin-D level.	Vitamin D	44-53	fibronectin type III domain containing 5	Homo sapiens	89-95
34338991-1	2021	Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3).	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	63-81
34338991-1	2021	Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3).	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	83-86
34669872-0	2021	Comment on "Vitamin D status influences cytokine production and MALAT1 expression from the PBMCs of patients with coronary artery disease and healthy controls".	Vitamin D	12-21	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	64-70
35531196-4	2022	Patients with CP are at an increased risk of vitamin D deficiency and as a result reduced bone mineral density, bone fragility, osteopenia, and rickets.	Vitamin D	45-54	ceruloplasmin	Homo sapiens	14-16
35531196-5	2022	The present review aims to combine and summarize available evidence, regarding the epidemiology, underlying contributing factors, clinical consequences, and treatment interventions of vitamin D deficiency in children with CP.	Vitamin D	184-193	ceruloplasmin	Homo sapiens	222-224
35619572-2	2022	The aim of this study is to evaluate the association between FF vitamin D levels and baseline anti-Mullerian hormone (AMH) / ART outcomes.	Vitamin D	64-73	anti-Mullerian hormone	Homo sapiens	118-121
34354449-1	2021	Background: Group-specific component (GC) and cytochrome P450 Family 2 Subfamily R Member 1 (CYP2R1) genes are one of the vital genes involved in the vitamin D (vitD) metabolic pathway.	Vitamin D	150-159	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	46-91
35619572-5	2022	Multivariable linear regression analysis was used to assess the association between baseline AMH and FF vitamin D levels with adjustment for basal FSH and serum vitamin D levels.	Vitamin D	104-113	anti-Mullerian hormone	Homo sapiens	93-96
35619572-5	2022	Multivariable linear regression analysis was used to assess the association between baseline AMH and FF vitamin D levels with adjustment for basal FSH and serum vitamin D levels.	Vitamin D	161-170	anti-Mullerian hormone	Homo sapiens	93-96
35619572-6	2022	RESULTS: Both the AMH and serum vitamin D were significant predictors for FF vitamin D.	Vitamin D	77-86	anti-Mullerian hormone	Homo sapiens	18-21
35132380-0	2022	Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling.	Vitamin D	15-24	sirtuin 1	Mus musculus	0-5
34354449-1	2021	Background: Group-specific component (GC) and cytochrome P450 Family 2 Subfamily R Member 1 (CYP2R1) genes are one of the vital genes involved in the vitamin D (vitD) metabolic pathway.	Vitamin D	150-159	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	93-99
35057792-12	2022	A new subset of macrophages with M2-type polarization double expressed MLPH + /CD206 + was found in mice having pneumoconiosis but markedly decreased after the Vitamin D treatment.	Vitamin D	160-169	melanophilin	Mus musculus	71-75
34246812-7	2021	Gene expression profiles for other known fibroblast immune mediators (SAA3 and CCL20) did not show significant differences between haplotypes but NOS2 gene expression was significantly elevated in response to vitamin D, even above the level detected in response to both TLR ligands.	Vitamin D	209-218	serum amyloid A 3	Bos taurus	70-74
35057792-13	2022	Activated MLPH + /CD206 + M2 macrophages secreted TGF-beta1 and are sensitive to Vitamin D treatment.	Vitamin D	81-90	melanophilin	Mus musculus	10-14
34991614-7	2022	RESULTS: Women with preeclampsia had 14.5% lower serum vitamin D levels than women in the control group (16.5 ng/ml vs. 19 ng/ml, p = 0.014) with 64.5% higher sFlt-1 levels (11,600 pg/ml vs. 7050 pg/ml, p < 0.001) and greater than 2 times higher endoglin levels (18.6 ng/ml vs. 8.7 ng/ml, < 0.001).	Vitamin D	55-64	endoglin	Homo sapiens	246-254
34343538-6	2022	Specific polymorphisms of vitamin D family genes were found to correlate with uveitis in ankylosing spondylitis, Behcet"s disease, VKH, and HLA B27-positive patients.	Vitamin D	26-35	major histocompatibility complex, class I, B	Homo sapiens	140-147
35011732-5	2022	In future, vitamin D and/or biotherapies targeting the IL1beta pathway may improve muscle wasting and subsequently CMBD, but this remains to be proven.	Vitamin D	11-20	interleukin 1 alpha	Homo sapiens	55-62
34137732-10	2021	To date, this is the largest cohort series analyzeing CYP2R1-related 25-hydroxylase deficiency worldwide, supporting its major role in 25-hydroxylation of vitamin-D.	Vitamin D	155-164	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	54-60
34859252-2	2022	This study aimed to summarize previous studies on the associations of vitamin D levels with the risk of gestational diabetes mellitus (GDM), pre-eclampsia (PE), gestational hypertension (GH), and caesarean section (C-section), and to clarify the dose-response trends.	Vitamin D	70-79	gamma-glutamyl hydrolase	Homo sapiens	187-189
35096006-9	2021	Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6.	Vitamin D	75-84	interferon alpha inducible protein 6	Homo sapiens	164-168
34377241-10	2021	AMA decreased NEFH (neurofilament protein) and MAP2 (microtubule binding protein) expression in offspring hippocampus, but vitamin D supplementation before pregnancy promoted NEFH and MAP2.	Vitamin D	123-132	neurofilament, heavy polypeptide	Mus musculus	14-18
2525134-1	1989	The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], inhibits the proliferation of T lymphocytes and production of growth-promoting factors (including interleukin-2) (IL2) in CTLL2 murine cells.	Vitamin D	21-30	interleukin 2	Mus musculus	171-184
2525134-1	1989	The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], inhibits the proliferation of T lymphocytes and production of growth-promoting factors (including interleukin-2) (IL2) in CTLL2 murine cells.	Vitamin D	21-30	interleukin 2	Mus musculus	187-190
34377241-10	2021	AMA decreased NEFH (neurofilament protein) and MAP2 (microtubule binding protein) expression in offspring hippocampus, but vitamin D supplementation before pregnancy promoted NEFH and MAP2.	Vitamin D	123-132	neurofilament, heavy polypeptide	Mus musculus	175-179
34143450-6	2021	Torin-1 (5 mg/kg/day), an mTOR inhibitor, significantly decreased aortic medial calcification accompanied with decreased expression of osteogenic markers like osteopontin (OSP) and runt-related transcription factor 2 (RUNX2) and upregulation of smooth muscle 22alpha (SM22-alpha) in mice receiving high dose of Vitamin D (500 000 IU/kg/day).	Vitamin D	311-320	runt related transcription factor 2	Mus musculus	181-216
2471520-0	1989	Methylation of the vitamin D-dependent CaBP gene (calbindin 9 Kd) does not mediate tissue or vitamin D regulation.	Vitamin D	19-28	S100 calcium binding protein G	Rattus norvegicus	39-43
34143450-6	2021	Torin-1 (5 mg/kg/day), an mTOR inhibitor, significantly decreased aortic medial calcification accompanied with decreased expression of osteogenic markers like osteopontin (OSP) and runt-related transcription factor 2 (RUNX2) and upregulation of smooth muscle 22alpha (SM22-alpha) in mice receiving high dose of Vitamin D (500 000 IU/kg/day).	Vitamin D	311-320	runt related transcription factor 2	Mus musculus	218-223
34143450-6	2021	Torin-1 (5 mg/kg/day), an mTOR inhibitor, significantly decreased aortic medial calcification accompanied with decreased expression of osteogenic markers like osteopontin (OSP) and runt-related transcription factor 2 (RUNX2) and upregulation of smooth muscle 22alpha (SM22-alpha) in mice receiving high dose of Vitamin D (500 000 IU/kg/day).	Vitamin D	311-320	transgelin	Mus musculus	268-278
34696567-6	2021	Sea fish, as the main dietary vitamin D source, were known to 58% of respondents.	Vitamin D	30-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
2618862-0	1989	Structure of the rat vitamin D-induced calbindin-D9K gene and evolution of the EF-hand calcium-binding protein family.	Vitamin D	21-30	S100 calcium binding protein G	Rattus norvegicus	39-52
35574655-3	2022	Researchers have reported that vitamin D deficiency is associated with brain calcification and reduction in calcification occurs with vitamin D receptor agonist calcitriol through upregulation of SLC20A2.	Vitamin D	31-40	solute carrier family 20 member 2	Homo sapiens	196-203
2511166-6	1989	Calbindin-D9K immunoreactivity was low or absent from the cytoplasm of osteocytes in trabecular bone from severely vitamin D-deficient rats and restored in vitamin D-deficient rats given a single dose of 1,25(OH)2-VitD3.	Vitamin D	115-124	S100 calcium binding protein G	Rattus norvegicus	0-13
2511166-6	1989	Calbindin-D9K immunoreactivity was low or absent from the cytoplasm of osteocytes in trabecular bone from severely vitamin D-deficient rats and restored in vitamin D-deficient rats given a single dose of 1,25(OH)2-VitD3.	Vitamin D	156-165	S100 calcium binding protein G	Rattus norvegicus	0-13
2511166-7	1989	Thus, the synthesis of immunoreactive calbindin-D9K by osteoblasts and osteocytes in trabecular bone is vitamin D-dependent.	Vitamin D	104-113	S100 calcium binding protein G	Rattus norvegicus	38-51
35619053-0	2022	Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice.	Vitamin D	11-20	runt related transcription factor 2	Mus musculus	91-96
3260120-1	1988	Previous reports of the distribution of calbindin, a 28 kDa vitamin D-induced calcium-binding protein, in the mammalian peripheral vestibular system postulated that this protein was involved in the calcium-dependent mechanisms occurring in the hair cells and ganglion cells.	Vitamin D	60-69	calbindin 1	Homo sapiens	40-49
35631274-3	2022	This explorative study aims to investigate whether myostatin and irisin are associated with metabolic parameters, including the vitamin D status in pediatric patients with severe obesity.	Vitamin D	128-137	fibronectin type III domain containing 5	Homo sapiens	65-71
3476614-10	1987	In developing rat molars, the time-course of appearance of CaBP, a protein dependent for its synthesis on the vitamin D endocrine system in other organ systems, suggests a potential direct role of this hormonal system in enamel mineralization.	Vitamin D	110-119	S100 calcium binding protein G	Rattus norvegicus	59-63
35134855-0	2022	Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling.	Vitamin D	88-97	microtubule associated protein tau	Homo sapiens	39-42
3688432-1	1987	A sensitive dot immunobinding assay has been developed for the quantitative determination of vitamin D-dependent calcium-binding protein (calbindin-D28k; CaBP) in rat and human kidney and brain.	Vitamin D	93-102	S100 calcium binding protein G	Rattus norvegicus	154-158
35134855-10	2022	Summary Sentence: Progesterone and interferon tau regulate phosphate, calcium, and vitamin D signaling during the ovine peri-implantation period.	Vitamin D	83-92	microtubule associated protein tau	Homo sapiens	46-49
35443443-14	2022	A weak negative correlation of IL-1 and TNF-alpha was seen with vitamin D in diabetics without nephropathy, whereas IL-6 had a weak negative correlation with vitamin D in diabetics with nephropathy.	Vitamin D	64-73	interleukin 1 alpha	Homo sapiens	31-35
3780535-1	1986	The in vivo stimulation of vitamin D-dependent calcium-binding protein (9 K CaBP) synthesis by 1,25-dihydroxycholecalciferol [1,25(OH)2D3] in the rat duodenum has been analyzed using a specific [32P]complementary DNA probe for rat 9 K CaBP and inhibitors of RNA transcription (actinomycin D, alpha-amanitin) or protein synthesis (cycloheximide).	Vitamin D	27-36	S100 calcium binding protein G	Rattus norvegicus	76-80
3780535-1	1986	The in vivo stimulation of vitamin D-dependent calcium-binding protein (9 K CaBP) synthesis by 1,25-dihydroxycholecalciferol [1,25(OH)2D3] in the rat duodenum has been analyzed using a specific [32P]complementary DNA probe for rat 9 K CaBP and inhibitors of RNA transcription (actinomycin D, alpha-amanitin) or protein synthesis (cycloheximide).	Vitamin D	27-36	S100 calcium binding protein G	Rattus norvegicus	235-239
35099571-0	2022	Vitamin D can reduce severity in COVID-19 through regulation of PD-L1.	Vitamin D	0-9	CD274 molecule	Homo sapiens	64-69
3779381-1	1986	Rat brain vitamin D-dependent calcium-binding protein (D-CaBP) was assessed for vitamin D dependency, calcium binding and ultrastructural localization within neurons.	Vitamin D	10-19	S100 calcium binding protein G	Rattus norvegicus	57-61
35099571-12	2022	Thus, vitamin D supplementation could eliminate the suppressive effect of PD-L1 on CD4+ and CD8+ T cells, preventing lymphopenia and reducing disease severity and mortality in patients infected with COVID-19.	Vitamin D	6-15	CD274 molecule	Homo sapiens	74-79
35091041-5	2022	We previously demonstrated that vitamin D rescues the aberrant NF-kappaB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo.	Vitamin D	32-41	methyl CpG binding protein 2	Mus musculus	115-120
2943279-1	1986	The vitamin D-dependent, calcium-binding protein from rat kidney, calbindin D28k (renal CaBP) specifically stimulates Ca,Mg-ATPase activity of human erythrocyte plasma membranes in a dose-dependent, calcium-sensitive manner.	Vitamin D	4-13	S100 calcium binding protein G	Rattus norvegicus	88-92
35091041-5	2022	We previously demonstrated that vitamin D rescues the aberrant NF-kappaB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo.	Vitamin D	32-41	methyl CpG binding protein 2	Mus musculus	312-317
3459646-1	1986	The vitamin D-dependent calcium-binding protein (CaBP), cholecalcin or calbindin, is one of the best documented molecular expressions of 1,25-dihydroxyvitamin D, the hormonal metabolite of vitamin D.	Vitamin D	4-13	S100 calcium binding protein G	Rattus norvegicus	56-67
35091041-5	2022	We previously demonstrated that vitamin D rescues the aberrant NF-kappaB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo.	Vitamin D	175-184	methyl CpG binding protein 2	Mus musculus	312-317
35091041-6	2022	Here, we have identified over 200 genes whose dysregulated expression in the Mecp2+/- cortex is modulated by dietary vitamin D.	Vitamin D	117-126	methyl CpG binding protein 2	Mus musculus	77-82
35091041-8	2022	Further, there is a disruption in the homeostasis of the vitamin D synthesis pathway in Mecp2+/- mice, and motor and anxiety-like behavioral phenotypes in Mecp2+/- mice correlate with circulating vitamin D levels.	Vitamin D	57-66	methyl CpG binding protein 2	Mus musculus	88-93
3503543-1	1986	The effect of parathyroid hormone (PTH) on the time course of glucose-6-phosphate dehydrogenase (G6PD) activity in the distal convoluted tubule of a vitamin D-depleted guinea pig was determined using quantitative cytochemistry.	Vitamin D	149-158	glucose-6-phosphate 1-dehydrogenase	Cavia porcellus	62-95
3503543-1	1986	The effect of parathyroid hormone (PTH) on the time course of glucose-6-phosphate dehydrogenase (G6PD) activity in the distal convoluted tubule of a vitamin D-depleted guinea pig was determined using quantitative cytochemistry.	Vitamin D	149-158	glucose-6-phosphate 1-dehydrogenase	Cavia porcellus	97-101
35091041-8	2022	Further, there is a disruption in the homeostasis of the vitamin D synthesis pathway in Mecp2+/- mice, and motor and anxiety-like behavioral phenotypes in Mecp2+/- mice correlate with circulating vitamin D levels.	Vitamin D	57-66	methyl CpG binding protein 2	Mus musculus	155-160
35091041-8	2022	Further, there is a disruption in the homeostasis of the vitamin D synthesis pathway in Mecp2+/- mice, and motor and anxiety-like behavioral phenotypes in Mecp2+/- mice correlate with circulating vitamin D levels.	Vitamin D	196-205	methyl CpG binding protein 2	Mus musculus	88-93
3509739-1	1986	We investigated the stimulation of creatine kinase (CK) and ornithine decarboxylase (ODC) by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] in doses ranging from 1.625 to 6500 pmol in 4-week-old vitamin D-deficient chicks.	Vitamin D	107-116	ornithine decarboxylase 1	Rattus norvegicus	60-83
3509739-1	1986	We investigated the stimulation of creatine kinase (CK) and ornithine decarboxylase (ODC) by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] in doses ranging from 1.625 to 6500 pmol in 4-week-old vitamin D-deficient chicks.	Vitamin D	107-116	ornithine decarboxylase 1	Rattus norvegicus	85-88
35091041-8	2022	Further, there is a disruption in the homeostasis of the vitamin D synthesis pathway in Mecp2+/- mice, and motor and anxiety-like behavioral phenotypes in Mecp2+/- mice correlate with circulating vitamin D levels.	Vitamin D	196-205	methyl CpG binding protein 2	Mus musculus	155-160
35213326-2	2022	Here, we investigate the relation between CHC use and vitamin D metabolism to elucidate its clinical interpretation.	Vitamin D	54-63	clathrin heavy chain	Homo sapiens	42-45
3753716-0	1986	In situ detection of vitamin D-induced calcium-binding protein (9-kDa CaBP) messenger RNA in rat duodenum.	Vitamin D	21-30	S100 calcium binding protein G	Rattus norvegicus	64-74
3753716-1	1986	We have previously described the molecular cloning of a cDNA fragment synthesized from rat duodenal mRNA coding for a 9000-dalton vitamin D-induced calcium-binding protein (9-kDa CaBP) (3).	Vitamin D	130-139	S100 calcium binding protein G	Rattus norvegicus	148-184
35213326-12	2022	CONCLUSION: This confirms a clinical impact of CHC on vitamin D levels in adolescents.	Vitamin D	54-63	clathrin heavy chain	Homo sapiens	47-50
35405984-1	2022	Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	44-52
3940928-0	1986	Changes in the concentrations of parathyroid hormone and ionic calcium in the plasma of laying hens during the egg cycle in relation to dietary deficiencies of calcium and vitamin D.	Vitamin D	172-181	parathyroid hormone	Gallus gallus	33-52
35405984-1	2022	Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism.	Vitamin D	78-87	hepcidin antimicrobial peptide	Homo sapiens	44-52
35352989-9	2022	When examining PA and BMI as continuous variables, OR for vitamin D deficiency were 0.95 (95% confidence interval (CI): 0.93-0.96) per 250 MET-minutes/week increment in PA, and 1.20 (95% CI: 1.17-1.23) per 2 kg/m2 increment in BMI.	Vitamin D	58-67	SAFB like transcription modulator	Homo sapiens	139-142
3885666-18	1985	The synthesis of D-CaBP is dependent upon vitamin D.	Vitamin D	42-51	S100 calcium binding protein G	Rattus norvegicus	19-23
34348356-4	2022	Vitamin D has been shown to regulate mucosa-resident cell populations such as Th17 or innate lymphoid cells and critical mucosal cytokine IL-22; however, their therapeutic potential has not been put to test in preclinical mouse models.	Vitamin D	0-9	interleukin 22	Mus musculus	138-143
4038405-0	1985	Vitamin D status regulates 25-hydroxyvitamin D3-1 alpha-hydroxylase and its responsiveness to parathyroid hormone in the chick.	Vitamin D	0-9	parathyroid hormone	Gallus gallus	94-113
6334780-9	1984	Our findings showed vitamin D metabolites to be present in human CSF.	Vitamin D	20-29	colony stimulating factor 2	Homo sapiens	65-68
6547026-1	1984	The in vitro incubation of chick renal cells with parathyroid hormone (PTH) resulted in the inhibition of Na+-dependent phosphate uptake when the cells were isolated from 1,25-dihydroxycholecalciferol 1,25-dihydroxycholecalciferol [1,25-(OH)2D3]-repleted chicks but not when the cells came from vitamin D-deficient animals.	Vitamin D	295-304	parathyroid hormone	Gallus gallus	50-69
6689055-0	1983	Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite.	Vitamin D	64-73	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-17
6196546-1	1983	To extend our previous observations on the regulation of CaBP biosynthesis by 1,25-dihydroxyvitamin D3, we have studied the specific mRNA encoding this protein in vitamin D-deficient and in vitamin D-repleted rats as well as the rate of its induction after a single injection of 1,25(OH)2D3 to vitamin D-deficient animals.	Vitamin D	92-101	S100 calcium binding protein G	Rattus norvegicus	57-61
6196546-3	1983	CaBP-mRNA activity and cytoplasmic CaBP (measured by radioimmunoassay), dramatically decreased in rats previously fed a vitamin D-free diet for 5 weeks but neither parameter was zero.	Vitamin D	120-129	S100 calcium binding protein G	Rattus norvegicus	0-4
6196546-3	1983	CaBP-mRNA activity and cytoplasmic CaBP (measured by radioimmunoassay), dramatically decreased in rats previously fed a vitamin D-free diet for 5 weeks but neither parameter was zero.	Vitamin D	120-129	S100 calcium binding protein G	Rattus norvegicus	35-39
6196546-4	1983	In vitamin D-deficient rats, a single injection of 1,25(OH)2D3 led to an increase in CaBP-mRNA activity within 2 h. This CaBP-mRNA activity peaked at about 4-6 h and thereafter declined to low value by 48 h, and the changes in mRNA activity always preceded the changes in cytosolic CaBP concentration.	Vitamin D	3-12	S100 calcium binding protein G	Rattus norvegicus	85-89
6196546-4	1983	In vitamin D-deficient rats, a single injection of 1,25(OH)2D3 led to an increase in CaBP-mRNA activity within 2 h. This CaBP-mRNA activity peaked at about 4-6 h and thereafter declined to low value by 48 h, and the changes in mRNA activity always preceded the changes in cytosolic CaBP concentration.	Vitamin D	3-12	S100 calcium binding protein G	Rattus norvegicus	121-125
6196546-4	1983	In vitamin D-deficient rats, a single injection of 1,25(OH)2D3 led to an increase in CaBP-mRNA activity within 2 h. This CaBP-mRNA activity peaked at about 4-6 h and thereafter declined to low value by 48 h, and the changes in mRNA activity always preceded the changes in cytosolic CaBP concentration.	Vitamin D	3-12	S100 calcium binding protein G	Rattus norvegicus	121-125
6604524-2	1983	In the epiphysis there was a 6.4-fold increase in ornithine decarboxylase activity 5 h after a single injection of 24R,25-dihydroxycholecalciferol but not of 24S,25-dihydroxycholecalciferol or other vitamin D metabolites.	Vitamin D	199-208	ornithine decarboxylase 1	Rattus norvegicus	50-73
6245328-0	1980	Gas--liquid chromatographic determination of vitamin D in multiple vitamin tablets and their raw materials.	Vitamin D	45-54	gastrin	Homo sapiens	0-3
6245329-0	1980	Gas--liquid chromatographic determination of vitamin D.	Vitamin D	45-54	gastrin	Homo sapiens	0-3
443430-7	1979	The observed changes in calcium active transport with age and diet may be explained by the parallel changes in the vitamin D-dependent CaBP content of the intestine.	Vitamin D	115-124	S100 calcium binding protein G	Rattus norvegicus	135-139
743617-2	1978	Daily administration of vitamin D for 11 days decreased PNMT activity and increased adrenal norepinephrine, whereas adrenal epinephrine remained unaffected.	Vitamin D	24-33	phenylethanolamine-N-methyltransferase	Rattus norvegicus	56-60
734693-1	1978	Since intestinal calcium-binding protein (CaBP) can be regarded as an expression of the hormone-like action of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the duodenal enterocyte we have investigated the potential biological activity of 25R and 25S,26-(OH)2D3 (two recently synthesized epimers of vitamin D3 metabolite) to promote intestinal CaBP production as compared to bone calcium mobilization in vitamin D and calcium-deficient rats.	Vitamin D	125-134	S100 calcium binding protein G	Rattus norvegicus	42-46
24077-6	1978	Although more lead bound to the higher molecular weight fraction and more calcium bound to the lower molecular weight vitamin D-induced CaBP, substantial amounts of lead and calcium were found in both fractions.	Vitamin D	118-127	S100 calcium binding protein G	Rattus norvegicus	136-140
828536-2	1976	Vitamin D-dependent CaBP isolated from Rat renal cortex (rCaBP) was measured in phosphorus-depleted (OP) and control (C) Rats, either vitamin D-deficient (OD) or vitamin D-supplemented (1 or 10 i.	Vitamin D	0-9	S100 calcium binding protein G	Rattus norvegicus	20-24
828536-2	1976	Vitamin D-dependent CaBP isolated from Rat renal cortex (rCaBP) was measured in phosphorus-depleted (OP) and control (C) Rats, either vitamin D-deficient (OD) or vitamin D-supplemented (1 or 10 i.	Vitamin D	0-9	S100 calcium binding protein G	Rattus norvegicus	57-62
828536-5	1976	The results indicated that phosphorus deprivation resulted in the increase in the vitamin D-dependent rCaBP as well as in the intestinal CaBP.	Vitamin D	82-91	S100 calcium binding protein G	Rattus norvegicus	102-107
828536-5	1976	The results indicated that phosphorus deprivation resulted in the increase in the vitamin D-dependent rCaBP as well as in the intestinal CaBP.	Vitamin D	82-91	S100 calcium binding protein G	Rattus norvegicus	103-107
828536-6	1976	As a marked hypercalciuria was noted in all OP Rats and as the rCaBP activity was high in vitamin D-supplemented Rats and hardly detectable in vitamin D-deficient Rats, the implication of the rCaBP in the large hypercalciuria can be definitely ruled out.	Vitamin D	90-99	S100 calcium binding protein G	Rattus norvegicus	63-68
828536-6	1976	As a marked hypercalciuria was noted in all OP Rats and as the rCaBP activity was high in vitamin D-supplemented Rats and hardly detectable in vitamin D-deficient Rats, the implication of the rCaBP in the large hypercalciuria can be definitely ruled out.	Vitamin D	90-99	S100 calcium binding protein G	Rattus norvegicus	192-197
828536-10	1976	The high CaBP activity probably resulting from the renal synthesis of 1,25-dihydroxycholecalciferol stimulated by phosphorus-deprivation could represent the molecular basis of the calcium tubular reabsorption increased by vitamin D.	Vitamin D	222-231	S100 calcium binding protein G	Rattus norvegicus	9-13
13475342-0	1957	The effect of vitamin D upon bone mineralization of Ca45 and Sr89 as chlorides and as phosphopeptides.	Vitamin D	14-23	LUC7 like	Homo sapiens	61-65
33942213-10	2021	CONCLUSION: Vitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway.	Vitamin D	12-21	fibronectin 1	Rattus norvegicus	68-79
34348356-10	2022	Daily vitamin D injections ameliorated intestinal inflammation and elevated intestinal IL-22 levels compared with control groups.	Vitamin D	6-15	interleukin 22	Mus musculus	87-92
35228490-3	2022	Vitamin D deficiency is prevalent among patients of ACS.	Vitamin D	0-9	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	52-55
34004333-0	2021	Analysis of the effect of vitamin D supplementation and sex on Vdr, Cyp2r1 and Cyp27b1 gene expression in Wistar rats" tissues.	Vitamin D	26-35	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	79-86
2551904-2	1989	We have used specific cDNAs to the rat vitamin D receptor (VDR) and to the mammalian vitamin D-dependent calcium-binding proteins (calbindin-D9k in intestine and calbindin-D28k in kidney) in order to obtain a better understanding of the regulation of the VDR gene and its relationship to calbindin gene expression.	Vitamin D	39-48	vitamin D receptor	Rattus norvegicus	59-62
34004333-7	2021	However, we noticed evident downregulation of Cyp27b1 gene by vitamin D supplementation in the liver and kidney in a dose-dependent manner.	Vitamin D	62-71	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	46-53
34002827-0	2021	Vitamin D and iron levels correlate weakly with hepcidin levels in postoperative patients with digestive neoplasms undergoing open abdominal surgery.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	48-56
34002827-2	2021	Vitamin D impacts hepcidin levels.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	18-26
2551904-5	1989	Vitamin D-deficient rats responded to dexamethasone treatment (100 micrograms/100 g of body weight/day for 4 days) with a 2.5-fold increase in intestinal VDR mRNA which was accompanied by a 4-fold decrease in intestinal calbindin-D9k mRNA.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	154-157
34002827-8	2021	CONCLUSIONS: The correlations between vitamin D and hepcidin levels, as well as between hepcidin and serum iron levels, are weak.	Vitamin D	38-47	hepcidin antimicrobial peptide	Homo sapiens	52-60
34002827-9	2021	Interindividual variability in iron-hepcidin-vitamin D regulation might be wide and other regulatory mechanisms might also play important roles in inflammatory anemia modulation in the perioperative period.	Vitamin D	45-54	hepcidin antimicrobial peptide	Homo sapiens	36-44
33596158-0	2021	l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes.	Vitamin D	36-45	C-C motif chemokine ligand 2	Homo sapiens	91-96
2551904-5	1989	Vitamin D-deficient rats responded to dexamethasone treatment (100 micrograms/100 g of body weight/day for 4 days) with a 2.5-fold increase in intestinal VDR mRNA which was accompanied by a 4-fold decrease in intestinal calbindin-D9k mRNA.	Vitamin D	0-9	S100 calcium binding protein G	Rattus norvegicus	220-233
2544409-3	1989	The present studies were undertaken to investigate the ability of EGF to accelerate the postnatal induction of the vitamin D-dependent intestinal calcium-binding protein, calbindin-D9k.	Vitamin D	115-124	S100 calcium binding protein G	Rattus norvegicus	171-184
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Vitamin D	61-70	C-C motif chemokine ligand 2	Homo sapiens	265-299
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Vitamin D	61-70	C-C motif chemokine ligand 2	Homo sapiens	301-306
3290175-1	1988	Previous reports on calbindin, a 28 kDa vitamin D-induced calcium-binding protein, located in the mammalian peripheral vestibular system indicated that it is specifically distributed and postulated that it could play a role in the electrophysiological functioning of the sensory cells.	Vitamin D	40-49	calbindin 1	Homo sapiens	20-29
33476473-0	2021	Does vitamin D deficiency predispose to keloids via dysregulation of koebnerisin (S100A15)?	Vitamin D	5-14	S100 calcium binding protein A7A	Homo sapiens	82-89
3258818-0	1988	The effects of vitamin D metabolites on phospholipase A2 activity of growth zone and resting zone cartilage cells in vitro.	Vitamin D	15-24	phospholipase A2 group IB	Rattus norvegicus	40-56
32812524-12	2021	These results provide experimental evidence that long-term vitamin D deficiency promotes renal fibrosis and functional impairment, at least partially, through aggravating TGF-beta/Smad2/3-mediated EMT in middle-aged male mice.	Vitamin D	59-68	transforming growth factor alpha	Mus musculus	171-179
33484559-8	2021	Patients with hypoparathyroidism had higher CD3 -CD56 + natural killer (NK) cell count, which inversely correlated with calcium, PTH, and vitamin D levels.	Vitamin D	138-147	neural cell adhesion molecule 1	Homo sapiens	49-53
3258818-7	1988	The data suggest that changes in membrane fluidity due to phospholipase A2 activity may play a role in regulating alkaline phosphatase activity in response to vitamin D metabolites and that this regulation in GC and RC may proceed by different mechanisms.	Vitamin D	159-168	phospholipase A2 group IB	Rattus norvegicus	58-74
3259542-0	1988	1 alpha,25-Dihydroxyvitamin D3 and a novel vitamin D analogue MC 903 are potent inhibitors of human interleukin 1 in vitro.	Vitamin D	20-29	interleukin 1 alpha	Homo sapiens	100-113
33878208-0	2021	Role of vitamin D-vitamin D receptor signaling on hyperoxia-induced bronchopulmonary dysplasia in neonatal rats.	Vitamin D	8-17	vitamin D receptor	Rattus norvegicus	18-36
3425609-2	1987	One form, caused by the Hyp gene, is a counterpart of human X-linked hypophosphatemic "vitamin D-resistant rickets".	Vitamin D	87-96	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	24-27
33878208-11	2021	CONCLUSION: Vitamin D exerts protective effects on hyperoxia-induced BPD in neonatal rats by regulating vitamin D-VDR signaling pathways.	Vitamin D	12-21	vitamin D receptor	Rattus norvegicus	114-117
33878208-11	2021	CONCLUSION: Vitamin D exerts protective effects on hyperoxia-induced BPD in neonatal rats by regulating vitamin D-VDR signaling pathways.	Vitamin D	104-113	vitamin D receptor	Rattus norvegicus	114-117
3041108-8	1987	22-Hydroxyvitamin D3 and various vitamin D sterols were bound to vitamin D binding protein in the following order: 25-hydroxyvitamin D3.	Vitamin D	10-19	GC vitamin D binding protein	Gallus gallus	65-90
34017509-13	2021	Vitamin D level was significantly negatively correlated with IL-4, suggesting that vitamin D was closely related to inflammation.	Vitamin D	83-92	interleukin 4	Mus musculus	61-65
33418034-11	2021	They also provide evidence for PDIA3-mediated anti-inflammatory effects of vitamin D and vitamin D analog in these settings.	Vitamin D	75-84	protein disulfide isomerase associated 3	Mus musculus	31-36
33418034-11	2021	They also provide evidence for PDIA3-mediated anti-inflammatory effects of vitamin D and vitamin D analog in these settings.	Vitamin D	89-98	protein disulfide isomerase associated 3	Mus musculus	31-36
3144322-1	1987	The effect of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) on glucose-6-phosphate dehydrogenase (G6PD) activity in the distal convoluted tubule of a vitamin D-depleted guinea pig was determined using quantitative cytochemistry.	Vitamin D	148-157	glucose-6-phosphate 1-dehydrogenase	Cavia porcellus	96-100
33756086-0	2021	Does vitamin D affect the association between FTO rs9939609 polymorphism and depression?	Vitamin D	5-14	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	46-49
3030988-1	1987	1 alpha,25-Dihydroxyvitamin D3, a hormonally active form of vitamin D, induces anchorage-independent growth of BALB/3T3 A31-1-1 and NIH/3T3 cells with concomitant increase of their mRNA level of c-Ki-ras but not of c-Ha-ras or c-myc, through a receptor-mediated mechanism.	Vitamin D	20-29	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	195-203
33756086-8	2021	Serum vitamin D level had no effect on the association between FTO genotype and depression.Conclusion: A-allele of FTO rs9939609 polymorphism might be associated with depression independent of serum vitamin D level.	Vitamin D	6-15	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	115-118
33305626-0	2021	The modulating effects of vitamin D on the activity of beta-catenin in the endometrium of women with endometriosis: a randomized exploratory trial.	Vitamin D	26-35	catenin beta 1	Homo sapiens	55-67
3091093-1	1986	Cholecalciferol (calcitriol) the active hormonal form of vitamin D induces the synthesis of at least two intracellular calcium-binding proteins (Ka = 10(6) M-1), the cholecalcins (CaBP) in mammals.	Vitamin D	57-66	S100 calcium binding protein G	Rattus norvegicus	180-184
33305626-1	2021	AIMS: The aim of this prospective study was to investigate the effects of vitamin D on the expression and activity of beta-catenin, as the key molecule of the Wnt/beta-catenin signaling pathway, in endometriosis women.	Vitamin D	74-83	catenin beta 1	Homo sapiens	118-130
33305626-1	2021	AIMS: The aim of this prospective study was to investigate the effects of vitamin D on the expression and activity of beta-catenin, as the key molecule of the Wnt/beta-catenin signaling pathway, in endometriosis women.	Vitamin D	74-83	catenin beta 1	Homo sapiens	163-175
33305626-8	2021	CONCLUSIONS: It seems vitamin D can change the activity of beta-catenin protein in the endometrial cells of endometriosis patients.	Vitamin D	22-31	catenin beta 1	Homo sapiens	59-71
33305626-9	2021	Further studies on the therapeutic potential of vitamin D in modifying the beta-catenin activity in endometriosis patients are warranted.	Vitamin D	48-57	catenin beta 1	Homo sapiens	75-87
33139887-9	2021	In boys, LEAP-2 was positively correlated with leptin and negatively with vitamin D levels.	Vitamin D	74-83	liver enriched antimicrobial peptide 2	Homo sapiens	9-15
3509739-0	1986	Activity of ornithine decarboxylase and creatine kinase in soft and hard tissue of vitamin D-deficient chicks following parenteral application of 1,25-dihydroxyvitamin D3 or 24R,25-dihydroxyvitamin D3.	Vitamin D	83-92	ornithine decarboxylase 1	Rattus norvegicus	12-35
6546644-2	1984	Vitamin D deficiency abolished net calcium absorption [J net, -2 +/- 2 vs. 12 +/- 2 (SE) nmol X cm-2 X h-1, P less than 0.001], and 10 ng of 1,25(OH)2D3 raised J net to levels found in normal rats.	Vitamin D	0-9	solute carrier family 6 member 2	Rattus norvegicus	31-34
33642417-8	2021	In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration.	Vitamin D	31-40	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	121-127
33241290-9	2021	CONCLUSIONS: Active vitamin D ameliorates cardiac remodelling and normalizes renal Klotho expression in 5/6Nx rats but does not improve the cardiac phenotype in children with CKD Stages 3-5.	Vitamin D	20-29	Klotho	Rattus norvegicus	83-89
6546644-2	1984	Vitamin D deficiency abolished net calcium absorption [J net, -2 +/- 2 vs. 12 +/- 2 (SE) nmol X cm-2 X h-1, P less than 0.001], and 10 ng of 1,25(OH)2D3 raised J net to levels found in normal rats.	Vitamin D	0-9	solute carrier family 6 member 2	Rattus norvegicus	57-64
6693984-2	1984	CD1 mice were fed vitamin D-deficient or control diets containing 1.2% calcium and 0.5% phosphorus 8-12 weeks prior to breeding.	Vitamin D	18-27	CD1 antigen complex	Mus musculus	0-3
33197518-11	2021	The effect of vitamin D on NSCLC cells A549 and NCI-H1975 was correlated with the PI3K/AKT/mTOR signaling pathway.	Vitamin D	14-23	mechanistic target of rapamycin kinase	Mus musculus	91-95
6602556-4	1983	The level of CaBP, the vitamin D-dependent cytosolic calcium-binding protein (Mr, approximately or equal to 9,000), corresponded to the magnitude of the saturable component.	Vitamin D	23-32	S100 calcium binding protein G	Rattus norvegicus	13-17
32917645-3	2021	We tested the effects of supplemental vitamin D (1,000 I.U./day) and/or calcium (1,200 mg/day) on COX-2 and 15-HPGD expression in the morphologically-normal rectal mucosa from 62 colorectal adenoma patients in a placebo-controlled chemoprevention trial.	Vitamin D	38-47	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	111-115
32195696-2	2021	CCL20 is a potential therapeutic target in carcinogenesis, which mediates the protective effect of vitamin D or vitamin D analogue in autoimmune and cancer diseases.	Vitamin D	99-108	chemokine (C-C motif) ligand 20	Mus musculus	0-5
32195696-2	2021	CCL20 is a potential therapeutic target in carcinogenesis, which mediates the protective effect of vitamin D or vitamin D analogue in autoimmune and cancer diseases.	Vitamin D	112-121	chemokine (C-C motif) ligand 20	Mus musculus	0-5
32530517-9	2021	Mechanical loading showed a significant interaction with vitamin D deficiency with regard to mRNA expression of Vdr and Esr1.	Vitamin D	57-66	vitamin D receptor	Rattus norvegicus	112-115
32530517-9	2021	Mechanical loading showed a significant interaction with vitamin D deficiency with regard to mRNA expression of Vdr and Esr1.	Vitamin D	57-66	estrogen receptor 1	Rattus norvegicus	120-124
32474936-6	2021	The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin.	Vitamin D	19-28	secreted phosphoprotein 1	Homo sapiens	148-159
33415106-0	2020	Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling via Induction of G-CSF.	Vitamin D	0-9	colony stimulating factor 3	Homo sapiens	127-132
32769953-0	2020	VITAMIN D STATUS IS ASSOCIATED WITH HEPCIDIN AND HEMOGLOBIN CONCENTRATIONS IN PATIENTS WITH SEVERE TRAUMATIC INJURY.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	36-44
32769953-2	2020	Vitamin D has been shown to reduce proinflammatory cytokines and hepcidin concentrations.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	65-73
33331582-0	2020	Vitamin D status influences cytokine production and MALAT1 expression from the PBMCs of patients with coronary artery disease and healthy controls.	Vitamin D	0-9	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	52-58
33331582-7	2020	However, a lower level of MALAT1 and CD36 was observed in PBMCs of vitamin D deficient (<15 ng/ml) CAD and NCAD participants.	Vitamin D	67-76	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	26-32
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	26-35	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	79-85
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	26-35	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	208-214
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	79-85
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	208-214
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	79-85
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	208-214
33216035-4	2021	Further, vitamin D promotes the expression of LRP1 and P-gp in AD-animal model brains.	Vitamin D	9-18	phosphoglycolate phosphatase	Homo sapiens	55-59
33186385-4	2020	METHODS: We carried out a case-control study aimed to assess vitamin D serum levels together with the distribution of VDR FokI and BsmI in a population of 116 pregnant women with gestational hypertension (GH) and 69 normotensive pregnant women (CTR).	Vitamin D	61-70	gamma-glutamyl hydrolase	Homo sapiens	205-207
33186385-7	2020	Regression analysis showed that GH was significantly (p = 0.031) linked to vitamin D status.	Vitamin D	75-84	gamma-glutamyl hydrolase	Homo sapiens	32-34
33186385-8	2020	Vitamin D deficiency was associated with a threefold-increased risk of developing GH, while a normal vitamin D status was protective against this pregnancy disorder.	Vitamin D	0-9	gamma-glutamyl hydrolase	Homo sapiens	82-84
32915988-0	2020	Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis.	Vitamin D	15-24	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	50-56
32915988-1	2020	BACKGROUND: Studies on organ-specific autoimmune endocrine disorders showed correlations between disease risks and vitamin D pathways gene variants, such as CYP27B1 rs10877012 and rs4646536, or CYP2R1 rs10741657 single nucleotide polymorphisms.	Vitamin D	115-124	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	194-200
33000217-0	2020	Vitamin D receptor knockdown attenuates the antiproliferative, pro-apoptotic and anti-invasive effect of vitamin D by activating the Wnt/beta-catenin signaling pathway in papillary thyroid cancer.	Vitamin D	105-114	catenin beta 1	Homo sapiens	137-149
33000217-3	2020	Therefore, the present study aimed to determine the role of the VDR and its association with Wnt/beta-catenin signaling in vitamin D-treated PTC cells.	Vitamin D	123-132	catenin beta 1	Homo sapiens	97-109
33000217-11	2020	In conclusion, the present study revealed that VDR-KD attenuated the antiproliferative, pro-apoptotic and anti-invasive effects of vitamin D in PTC by activating the Wnt/beta-catenin signaling pathway.	Vitamin D	131-140	catenin beta 1	Homo sapiens	170-182
33107041-12	2021	Therefore, the mRNA levels of MCP-1 and IL-8 in hPDLCs were significantly decreased through the vitamin D pathway.	Vitamin D	96-105	C-C motif chemokine ligand 2	Homo sapiens	30-35
32911795-2	2020	Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1alpha-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review.	Vitamin D	41-50	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	163-169
32700398-6	2020	The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID-19 [19.00 ng/mL1 (95% confidence interval (CI) 18.41-19.59) vs. 20.55 (95% CI: 20.32-20.78)].	Vitamin D	16-25	L1 cell adhesion molecule	Mus musculus	125-128
33130670-3	2020	The purpose of the study was to identify the ability of vitamin D and tamoxifen estrogen receptor modulator to affect Klotho protein synthesis (under hypoxia in vitro modeling in brain and heart cells).	Vitamin D	56-65	Klotho	Rattus norvegicus	118-124
33130670-11	2020	Vitamin D (10-7) addition to the incubation medium of cardiomyocytes and neurocytes resulted in the increase of Klotho protein content by 56% on average, with 36% and 42% reduction of Ntz concentration, respectively.	Vitamin D	0-9	Klotho	Rattus norvegicus	112-118
33130670-12	2020	The registered effects of vitamin D are explained with its direct stimulating of the expression and synthesis of Klotho protein and limiting FGF23 hyperproduction.	Vitamin D	26-35	Klotho	Rattus norvegicus	113-119
32939414-11	2020	Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma.	Vitamin D	122-131	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	150-157
32939414-11	2020	Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma.	Vitamin D	122-131	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	159-166
32604067-8	2020	Using the method of immunofluorescent staining and western blot, vitamin D and 17beta-estradiol were demonstrated to upregulate each other"s receptors, including VDR, ERalpha, and ERbeta in the hippocampus of OVX rats.	Vitamin D	65-74	vitamin D receptor	Rattus norvegicus	162-165
32604067-8	2020	Using the method of immunofluorescent staining and western blot, vitamin D and 17beta-estradiol were demonstrated to upregulate each other"s receptors, including VDR, ERalpha, and ERbeta in the hippocampus of OVX rats.	Vitamin D	65-74	estrogen receptor 1	Rattus norvegicus	167-174
32604067-8	2020	Using the method of immunofluorescent staining and western blot, vitamin D and 17beta-estradiol were demonstrated to upregulate each other"s receptors, including VDR, ERalpha, and ERbeta in the hippocampus of OVX rats.	Vitamin D	65-74	estrogen receptor 2	Rattus norvegicus	180-186
32705172-8	2020	In NEC mice, vitamin D reduced intestinal tissue damage, decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha, and decreased the protein expression of cleaved caspase-3 and MDA.	Vitamin D	13-22	interleukin 1 alpha	Mus musculus	96-104
32485309-18	2020	The autophagic flux and TNF-alpha, IL-1beta, IL-6 and LC3BII in vitamin D group were significantly lower than those in vitamin D deficiency group.	Vitamin D	64-73	interleukin 1 alpha	Mus musculus	35-43
32824839-0	2020	Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?	Vitamin D	0-9	toll like receptor 4	Homo sapiens	141-145
32764491-8	2020	These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway.	Vitamin D	173-182	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	68-74
32467291-7	2020	Ingenuity pathway analysis was performed to identify upstream regulators and downstream signaling pathway genes differentially regulated by vitamin D, including TP63 and vitamin D receptor (VDR) mediated canonical pathways in particular.	Vitamin D	140-149	tumor protein p63	Homo sapiens	161-165
32251673-0	2020	Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-beta induced epithelial to mesenchymal transition.	Vitamin D	0-9	transforming growth factor alpha	Mus musculus	116-124
32251673-7	2020	Moreover, vitamin D inhibited EMT in response to TGF-beta, which was vitamin D receptor dependent.	Vitamin D	10-19	transforming growth factor alpha	Mus musculus	49-57
32251673-8	2020	In conclusion, vitamin D attenuates lung injury via stimulating ATII cells proliferation and migration, reducing epithelial cell apoptosis and inhibits TGF-beta induced EMT.	Vitamin D	15-24	transforming growth factor alpha	Mus musculus	152-160
32006872-12	2020	Altogether, these data support the hypothesis that FGF23 could drive vitamin D metabolism in the laying hen, as previously documented in other species and explain the tight link between P and Ca metabolisms.	Vitamin D	69-78	fibroblast growth factor 23	Gallus gallus	51-56
32452516-0	2020	Vitamin D-vitamin D receptor system downregulates expression of uncoupling proteins in brown adipocyte through interaction with hairless protein.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	10-28
32452516-2	2020	Moreover, vitamin D deficiency upregulated the expression of uncoupling protein 3 (Ucp3) in white adipose tissue and brown adipose tissue.	Vitamin D	10-19	uncoupling protein 3	Rattus norvegicus	61-81
32452516-2	2020	Moreover, vitamin D deficiency upregulated the expression of uncoupling protein 3 (Ucp3) in white adipose tissue and brown adipose tissue.	Vitamin D	10-19	uncoupling protein 3	Rattus norvegicus	83-87
32534577-5	2020	We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR).	Vitamin D	69-78	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	113-119
32102946-4	2020	We selected 21 SNPs in vitamin D-related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1, DHCR7, NADSYN1) to test genotype and genotype-treatment interactions in relation to prostate cancer.	Vitamin D	23-32	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	67-73
32529108-6	2020	In adolescents with obesity, 25(OH) vitamin D was inversely associated with leptin even after adjustment for body mass index (BMI) (r = -0.340, p = 0.009).	Vitamin D	36-45	leptin	Homo sapiens	76-82
32529108-10	2020	Conclusions: Adolescents with obesity had lower 25(OH) vitamin D, which may be associated with higher leptin levels.	Vitamin D	55-64	leptin	Homo sapiens	102-108
32529108-11	2020	Vitamin D supplementation may lead to HbA1c and leptin reductions, but also to an increase in LDL-C.	Vitamin D	0-9	leptin	Homo sapiens	48-54
32636886-9	2020	However, CTX positively correlated with vitamin D in both premenopausal (Spearman"s r = 0.228, P < 0.01) and postmenopausal (Spearman"s r = 0.244, P < 0.05) women.	Vitamin D	40-49	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	9-12
32636886-11	2020	Although vitamin D does not show any association with BMD, it affects bone remodeling, which is reflected by changes in the bone formation marker PINP and the bone resorption marker CTX.	Vitamin D	9-18	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	182-185
32366390-0	2020	Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/beta-Catenin Pathways.	Vitamin D	12-21	catenin beta 1	Homo sapiens	119-131
32366390-7	2020	CONCLUSION: Noncalcemic vitamin D hydroxyderivatives demonstrated antitumor activities against OSCC comparable to those of 1,25(OH)2D3 Their activities against SHH and the WNT/beta-catenin pathways provide insight for a possible target for OSCC treatment.	Vitamin D	24-33	sonic hedgehog signaling molecule	Homo sapiens	160-163
32366390-7	2020	CONCLUSION: Noncalcemic vitamin D hydroxyderivatives demonstrated antitumor activities against OSCC comparable to those of 1,25(OH)2D3 Their activities against SHH and the WNT/beta-catenin pathways provide insight for a possible target for OSCC treatment.	Vitamin D	24-33	catenin beta 1	Homo sapiens	176-188
31945466-8	2020	A chromatin immunoprecipitation assay identified two vitamin D response elements in the upstream region of the megalin gene that seemed to contribute to its expression.	Vitamin D	53-62	low density lipoprotein receptor-related protein 2	Mus musculus	111-118
32111498-4	2020	In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.	Vitamin D	102-111	heat shock protein family B (small) member 1	Homo sapiens	121-126
32111498-7	2020	RESULTS: The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p <0.001) as well as between RDW and serum PAB (r = 0.120 and p <0.001).	Vitamin D	62-71	heat shock protein family B (small) member 1	Homo sapiens	81-86
32111498-9	2020	The results showed increasing 1 unit of serum vitamin D can cause 3% decreases in anti hsp 27 values (OR = 0.97; CI 95% (0.96-0.99); p = 0.004).	Vitamin D	46-55	heat shock protein family B (small) member 1	Homo sapiens	87-93
32111498-12	2020	CONCLUSION: The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases.	Vitamin D	47-56	heat shock protein family B (small) member 1	Homo sapiens	157-162
32047095-6	2020	We also found suggestive cross-associated loci for neonatal and maternal vitamin D near immune genes, such as CXCL6-IL8 and ACKR1 We found no interactions with ASD.	Vitamin D	73-82	C-X-C motif chemokine ligand 6	Homo sapiens	110-115
31809868-0	2020	Obesity and leptin influence vitamin D metabolism and action in human marrow stromal cells.	Vitamin D	29-38	leptin	Homo sapiens	12-18
31809868-13	2020	In addition, leptin downregulated CYP24A1 and upregulated CYP27B1, CYP27A1 and VDR, which play vital roles in vitamin D metabolism.	Vitamin D	110-119	leptin	Homo sapiens	13-19
31809868-13	2020	In addition, leptin downregulated CYP24A1 and upregulated CYP27B1, CYP27A1 and VDR, which play vital roles in vitamin D metabolism.	Vitamin D	110-119	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	67-74
31809868-15	2020	This research demonstrates links between obesity, vitamin D metabolism, and osteoblastogenesis by which leptin"s direct effects on D-metabolism and osteoblast differentiation in hMSCs may protect bone from low s25(OH)D in obese subjects.	Vitamin D	50-59	leptin	Homo sapiens	104-110
32231239-1	2020	Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR.	Vitamin D	35-44	vitamin D receptor	Rattus norvegicus	64-82
32231239-1	2020	Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR.	Vitamin D	35-44	vitamin D receptor	Rattus norvegicus	84-87
32231239-1	2020	Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR.	Vitamin D	35-44	vitamin D receptor	Rattus norvegicus	103-106
32231239-1	2020	Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR.	Vitamin D	35-44	vitamin D receptor	Rattus norvegicus	103-106
31982586-1	2020	In this study, beta-cyclodextrin (beta-CD) molecules are used as molecular reservoirs and grafted onto chitosan molecules for calcitriol (VD3) loading, which is a hormonally active metabolite of vitamin D.	Vitamin D	195-204	adrenocortical dysplasia	Mus musculus	34-41
32219064-0	2020	Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation.	Vitamin D	38-47	maternally expressed 3	Homo sapiens	20-24
32219064-0	2020	Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation.	Vitamin D	38-47	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	105-110
32219064-8	2020	Clinical data demonstrated that MEG3 was positively associated with serum vitamin D concentrations in patients with CRC.	Vitamin D	74-83	maternally expressed 3	Homo sapiens	32-36
32219064-10	2020	These results indicate that vitamin D-activated MEG3 suppresses aerobic glycolysis in CRC cells via degradation of c-Myc.	Vitamin D	28-37	maternally expressed 3	Homo sapiens	48-52
32219064-10	2020	These results indicate that vitamin D-activated MEG3 suppresses aerobic glycolysis in CRC cells via degradation of c-Myc.	Vitamin D	28-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	115-120
6775702-1	1980	The vitamin D metabolite, 24,25-dihydroxyvitamin D-3, is made from 25-hydroxyvitamin D-3 by an enzyme (25-hydroxyvitamin D-3 24-hydroxylase) located in the renal mitochondria of vitamin D and calcium-replete chicks.	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Gallus gallus	103-139
32319119-2	2020	Vitamin D is converted to the relatively inactive metabolite, 25-hydroxyvitamin D3 [25(OH)D3 ], by CYP27A1 and CYP2R1 in the liver, then to 1,25(OH)2 D3 by a specific, mitochondrial enzyme, CYP27B1 (1alpha-hydroxylase) that is present primarily in the kidney.	Vitamin D	0-9	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	99-106
32319119-2	2020	Vitamin D is converted to the relatively inactive metabolite, 25-hydroxyvitamin D3 [25(OH)D3 ], by CYP27A1 and CYP2R1 in the liver, then to 1,25(OH)2 D3 by a specific, mitochondrial enzyme, CYP27B1 (1alpha-hydroxylase) that is present primarily in the kidney.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	111-117
32147032-0	2020	The effect of intramuscular megadose of vitamin D injections on E-selectin, CRP and biochemical parameters in vitamin D-deficient patients with type-2 diabetes mellitus: A randomized controlled trial.	Vitamin D	40-49	selectin E	Homo sapiens	64-74
6775702-1	1980	The vitamin D metabolite, 24,25-dihydroxyvitamin D-3, is made from 25-hydroxyvitamin D-3 by an enzyme (25-hydroxyvitamin D-3 24-hydroxylase) located in the renal mitochondria of vitamin D and calcium-replete chicks.	Vitamin D	41-50	cytochrome P450 family 24 subfamily A member 1	Gallus gallus	103-139
6774968-1	1980	Two immunologically similar, probably identical, binding proteins for vitamin D and its metabolites (DBP1 and DBP2) were isolated separately from rat serum after approximately 180-fold purification by novel procedures using Blue Sepharose CL-6B chromatography.	Vitamin D	70-79	DEAH-box helicase 16	Rattus norvegicus	110-114
31544572-5	2020	Vitamin D3 supplementation with HFD significantly increased the exploration of the novel object and the discrimination index and attenuated the alterations in the prefrontal cortex CAT and Achase expression.Conclusions: The present findings support the potential effect of vitamin D on recognition memory and cholinergic transmission in the prefrontal cortex and add to the pathophysiology of HFD consumption.	Vitamin D	273-282	acetylcholinesterase	Rattus norvegicus	189-195
564862-1	1978	Embryonic chick duodena were incubated, in vitro, for two days in the presence of vitamin D analogues and metabolites and the ability of PTH to potentiate the vitamin-D-dependent synthesis of CaBP measured.	Vitamin D	159-168	parathyroid hormone	Gallus gallus	137-140
31587178-3	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) acts as an anti-proliferative agent in human cancer by inhibiting the Wnt/beta-catenin pathway through the vitamin D receptor (VDR).	Vitamin D	11-20	catenin beta 1	Homo sapiens	155-167
31705962-3	2020	Vitamin D deficiency resulted in reduced levels of phosphorylated mTOR, and suppressed mTOR-dependent phosphorylation of 4E-BP1 and p70-S6K, implying a decrease in activity of the protein synthesis machinery.	Vitamin D	0-9	ribosomal protein S6 kinase B1	Rattus norvegicus	132-139
31705962-5	2020	Vitamin D deficiency or insufficiency also led to a decrease in expression of both myosin and actin-associated proteins (Myh1, Myh2, Myh7, Tnnc1& Tnnt1), which are essential for generation of the mechanical force needed for muscle contraction.	Vitamin D	0-9	myosin heavy chain 2	Rattus norvegicus	127-131
49052-3	1975	We show that the products of both Gc alleles, proteins Gc 1 and Gc 2 (distinguished electrophoretically), bind substantial quantities of vitamin D and 25-hydroxyvitamin D.	Vitamin D	137-146	solute carrier family 25 member 22	Homo sapiens	55-68
31972209-0	2020	The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway.	Vitamin D	61-70	BTB domain and CNC homolog 1	Rattus norvegicus	130-135
1167739-1	1975	Analytical gel electrophoresis of the vitamin D-dependent intestinal calcium-binding protein (CaBP) has demonstrated two protein bands (1 and 2) of similar molecular weight and similar specific binding activity.	Vitamin D	38-47	S100 calcium binding protein G	Rattus norvegicus	94-98
31838186-0	2020	In vitro studies revealed a downregulation of Wnt/beta-catenin cascade by active vitamin D and TX 527 analog in a Kaposi"s sarcoma cellular model.	Vitamin D	81-90	catenin beta 1	Homo sapiens	50-62
1208380-2	1975	The yield of previtamins and, consequently, vitamins D was higher with the use of erythemic lamps with luminophore E-2 and luminophore E-3 than with the use of lamps PRK-2.	Vitamin D	44-54	small nucleolar RNA, H/ACA box 63	Homo sapiens	135-138
32259002-2	2020	Some studies suggest that vitamin D may influence Anti-Mullerian hormone (AMH) and antral follicle count (AFC) as an ovarian reserve.	Vitamin D	26-35	anti-Mullerian hormone	Homo sapiens	74-77
32259002-3	2020	Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC.	Vitamin D	64-73	anti-Mullerian hormone	Homo sapiens	77-80
32033527-0	2020	Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.	Vitamin D	0-9	fibronectin type III domain containing 5	Homo sapiens	42-48
33625596-0	2021	SNP rs12794714 of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case-control study.	Vitamin D	50-59	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	18-24
32033527-1	2020	BACKGROUND: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-gamma coactivator 1alpha (PGC-1alpha) and irisin levels and these improvements may reduce insulin resistance (IR).	Vitamin D	12-21	fibronectin type III domain containing 5	Homo sapiens	122-128
32033527-2	2020	The aim was to assess the effects of vitamin D supplementation on SIRT1, irisin, and IR in overweight/obese type 2 diabetes (T2D) patients.	Vitamin D	37-46	fibronectin type III domain containing 5	Homo sapiens	73-79
33792853-10	2021	Experimental studies have demonstrated that low vitamin D may be implicated in adipose tissue differentiation and growth leading to obesity either by regulation of gene expression or through modulation of parathyroid hormone, calcium, and leptin.	Vitamin D	48-57	leptin	Homo sapiens	239-245
32012190-2	2020	The objectives in this study were to investigate whether two functional polymorphisms in GC and CYP2R1, respectively, previously shown to predict vitamin D concentrations, were associated with risk of colorectal cancer; and further, to assess gene-environment interaction between the polymorphisms and intake of vitamin D through diet and supplementation in relation to risk of colorectal cancer.	Vitamin D	146-155	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	96-102
32012190-2	2020	The objectives in this study were to investigate whether two functional polymorphisms in GC and CYP2R1, respectively, previously shown to predict vitamin D concentrations, were associated with risk of colorectal cancer; and further, to assess gene-environment interaction between the polymorphisms and intake of vitamin D through diet and supplementation in relation to risk of colorectal cancer.	Vitamin D	312-321	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	96-102
30649593-11	2020	CONCLUSIONS: Vitamin D may increase adiponectin and leptin concentrations in overweight/obese and vitamin D-deficient adults.	Vitamin D	13-22	leptin	Homo sapiens	52-58
33715104-0	2021	Two novel CYP2R1 mutations in a family with vitamin D-dependent rickets type 1b.	Vitamin D	44-53	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	10-16
30649593-11	2020	CONCLUSIONS: Vitamin D may increase adiponectin and leptin concentrations in overweight/obese and vitamin D-deficient adults.	Vitamin D	98-107	leptin	Homo sapiens	52-58
32053841-0	2020	Differential Impact of Insulin Sensitizers vs. Anti-Androgen on Serum Leptin Levels in Vitamin D Replete PCOS Women: A Six Month Open Labeled Randomized Study.	Vitamin D	87-96	leptin	Homo sapiens	70-76
32053841-2	2020	The study endeavors to comprehend the differential impact of insulin sensitizers vs. anti-androgen on serum leptin levels among women with PCOS rendered vitamin D replete with high VD oral supplement.	Vitamin D	153-162	leptin	Homo sapiens	108-114
33715104-1	2021	PURPOSE: Vitamin D-dependent rickets type 1b (VDDR1b) is a very rare autosomal recessive disorder caused by mutations in CYP2R1 that produces 25-hydroxylase.	Vitamin D	9-18	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	121-127
34044669-1	2022	OBJECTIVE: The main aim of this prospective study was to investigate the relationship between intrafollicular vitamin D and anti-Mullerian hormone (AMH) concentration and its impact on oocyte quality and developmental competence.	Vitamin D	110-119	anti-Mullerian hormone	Homo sapiens	148-151
30926948-2	2020	To date, whether there is an association between vitamin D and leptin levels independent from adiposity remains uncertain.	Vitamin D	49-58	leptin	Homo sapiens	63-69
30926948-8	2020	One-year increases in 25(OH) vitamin D levels were inversely correlated with 1-year changes in leptin levels (r = -0.41, p < 0.001).	Vitamin D	29-38	leptin	Homo sapiens	95-101
31756344-9	2020	CONCLUSION: Active vitamin D supplementation could potentially impede hepatocyte senescence and apoptosis via suppression of the p53 pathway, thus preventing the progression of NAFLD.	Vitamin D	19-28	transformation related protein 53, pseudogene	Mus musculus	129-132
34045549-0	2021	Vitamin D stimulates miR-26b-5p to inhibit placental COX-2 expression in preeclampsia.	Vitamin D	0-9	microRNA 26b	Homo sapiens	21-28
31924826-9	2020	Supplementation of 25-vitamin D was able to reduce the expression of TRL4, cathelicidin, and MCP-1 in the uremic environment.	Vitamin D	19-31	C-C motif chemokine ligand 2	Homo sapiens	93-98
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	monoamine oxidase A	Homo sapiens	269-288
31907356-5	2020	The reduction of miR-26a/b expression was also detected in the oral epithelium of vitamin D deficient or VDR knockout mice.	Vitamin D	82-91	microRNA 26a-1	Mus musculus	17-26
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	monoamine oxidase A	Homo sapiens	290-295
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Vitamin D	124-133	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	79-82
32441198-5	2020	Regarding CEA, there was no significant difference between the four groups at the end of intervention (P > .05).Conclusion: Results show that co-supplementation of vitamin D and omega-3 fatty acids co-supplementation, in colorectal cancer patients have beneficial impacts on inflammation and tumor marker CEA.	Vitamin D	164-173	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	10-13
33578174-0	2021	Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia.	Vitamin D	17-26	toll like receptor 4	Homo sapiens	92-96
32441198-5	2020	Regarding CEA, there was no significant difference between the four groups at the end of intervention (P > .05).Conclusion: Results show that co-supplementation of vitamin D and omega-3 fatty acids co-supplementation, in colorectal cancer patients have beneficial impacts on inflammation and tumor marker CEA.	Vitamin D	164-173	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	305-308
33693593-5	2021	Vitamin D treatment also inhibits p-STAT3, Zeb1 and vimentin by 52%, 75% and 77% respectively, and increases E-cadherin by 87%.	Vitamin D	0-9	vimentin	Homo sapiens	52-60
33692290-4	2021	Vitamin D increases regulatory T (Treg) cells which promote tolerance to allergens and prevent allergic inflammation, inducing the expression of filaggrin and cathelicidin in keratinocytes.	Vitamin D	0-9	filaggrin	Homo sapiens	145-154
31744213-0	2019	Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.	Vitamin D	0-9	sirtuin 1	Mus musculus	49-54
31744213-7	2019	Thus, we suggest that the observed protective effect of vitamin D on muscle fat accumulation and mitochondrial dysfunction in a positive manner via modulating AMPK/SIRT1 activation.	Vitamin D	56-65	sirtuin 1	Mus musculus	164-169
31463983-8	2019	Moreover, vitamin D deficiency significantly attenuated alcohol-induced sterol-regulated element-binding protein (SREBP)-1c activation, which regulates genes for hepatic fatty acid (FA) and TAG synthesis, and the expression of its target genes fatty acid synthase (Fasn) and acetyl-coenzyme- A carboxylase (Acc).	Vitamin D	10-19	sterol regulatory element binding transcription factor 1	Mus musculus	72-123
31463983-9	2019	In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation.	Vitamin D	13-22	carnitine palmitoyltransferase 1a, liver	Mus musculus	220-263
31463983-9	2019	In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation.	Vitamin D	13-22	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	265-316
33720865-5	2021	OBJECTIVE: We aimed at studying the s.otolin-1 as biomarker and significance of vit-D in BPPV.	Vitamin D	80-85	otolin 1	Homo sapiens	38-46
31824622-0	2019	Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis.	Vitamin D	0-9	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	20-26
33720865-10	2021	The relationship between the serum Otolin-1 and Vitamin-D was not statistically significant.	Vitamin D	48-57	otolin 1	Homo sapiens	35-43
33656700-0	2021	The genetic background and vitamin D supplementation can affect irisin levels in Prader-Willi syndrome.	Vitamin D	27-36	fibronectin type III domain containing 5	Homo sapiens	64-70
31824622-3	2019	The aim of this study was to investigate the effect of vitamin D on CTLA-4 gene expression in whole blood samples of patients with UC.	Vitamin D	55-64	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	68-74
31824622-7	2019	CTLA-4 fold changes were significantly higher in the vitamin D group compared with the placebo group (median +- IQR: 1.21 +- 2.3 vs. 1.00 +- 1.5, respectively; p = 0.007).	Vitamin D	53-62	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	0-6
31824622-8	2019	CONCLUSION The results of this study revealed that vitamin D administration in patients with UC enhances the CTLA-4 gene expression.	Vitamin D	51-60	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	109-115
31394158-8	2019	Vitamin D alleviated obstructive cholestatic damage as illustrated by total bilirubin as well as gamma glutamyl transferase (gamma-GT) serum levels.	Vitamin D	0-9	gamma-glutamyltransferase 1	Rattus norvegicus	97-123
31394158-8	2019	Vitamin D alleviated obstructive cholestatic damage as illustrated by total bilirubin as well as gamma glutamyl transferase (gamma-GT) serum levels.	Vitamin D	0-9	gamma-glutamyltransferase 1	Rattus norvegicus	125-133
33656700-11	2021	Our study revealed that in pediatric PWS the 25(OH) vitamin-D levels affected irisin serum concentration.	Vitamin D	52-61	fibronectin type III domain containing 5	Homo sapiens	78-84
33656700-12	2021	Indeed, patients who were not supplemented with vitamin D showed lower irisin levels than controls and patients performing the supplementation.	Vitamin D	48-57	fibronectin type III domain containing 5	Homo sapiens	71-77
33656700-13	2021	Multiple regression analysis showed that irisin levels in pediatric and adult PWS were predicted by the genetic background and 25(OH)-vitamin D levels, whereas in a group of 29 adult PWS also by intelligent quotient.	Vitamin D	134-143	fibronectin type III domain containing 5	Homo sapiens	41-47
30084276-2	2019	We aimed to investigate the association of serum PSA concentration with vitamin D and total oxidant/antioxidant levels.	Vitamin D	72-81	aminopeptidase puromycin sensitive	Homo sapiens	49-52
33656700-14	2021	CONCLUSION: We demonstrated the possible role of genetic background and vitamin-D supplementation on irisin serum levels in PWS patients.	Vitamin D	72-81	fibronectin type III domain containing 5	Homo sapiens	101-107
33619114-0	2021	Correction for Alam et al., Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.	Vitamin D	70-79	folate receptor 1 (adult)	Mus musculus	125-146
30316967-5	2019	Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D.	Vitamin D	163-172	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	110-116
30316967-5	2019	Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D.	Vitamin D	163-172	SEC23 homolog A, COPII coat complex component	Homo sapiens	127-133
33541709-6	2021	Hub genes, such as amyloid beta precursor protein (APP), CDH2, SPP1, and STC2, were significantly associated with functions related to extracellular matrix organization and vitamin D response.	Vitamin D	173-182	secreted phosphoprotein 1	Homo sapiens	63-67
31522448-6	2019	Vitamin D administration significantly reduced the monocyte chemoattractant protein (MCP)-1 concentrations in the HFD + vitamin D group compared with the HFD group and reduced liver Transforming growth factor beta (TGF-beta) levels in both vitamin D-treated groups (p&lt;0.05).	Vitamin D	0-9	C-C motif chemokine ligand 2	Rattus norvegicus	51-91
33637199-3	2021	identify HBEGF as a paracrine/autocrine factor in the proximal tubules of mice that mimics the inductive effect of FGF23 on the vitamin D-catabolizing enzyme 24-hydroxylase through a common mitogen-activated protein kinase-dependent pathway.	Vitamin D	128-137	heparin-binding EGF-like growth factor	Mus musculus	9-14
31405087-7	2019	The prevalence ratio (PR) of vitamin D deficiency decreased by 2% per year of age (PR 0.98; 95% CI (0.97, 0.99); p = 0.004) and was 1.6 times higher in those with low/sedentary, compared to moderate/high, physical activity levels (PR 1.64; 95% CI (1.12, 2.39); p = 0.011).	Vitamin D	29-38	transmembrane protein 37	Homo sapiens	231-235
31173888-0	2019	Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4+ T cells in asthmatic patients.	Vitamin D	62-71	leptin	Homo sapiens	6-12
33557015-5	2021	Vitamin D and adipokines, such as leptin and adiponectin, are possible mediators connecting obesity and SLE.	Vitamin D	0-9	leptin	Homo sapiens	34-40
31173888-7	2019	Interestingly, the in vitro immunomodulatory effects of vitamin D were inversely correlated with serum leptin levels.	Vitamin D	56-65	leptin	Homo sapiens	103-109
31173888-9	2019	The deleterious effects of leptin may also be due to its ability to counter-regulate the immunosuppressive effects of vitamin D.	Vitamin D	118-127	leptin	Homo sapiens	27-33
33472116-8	2021	After vitamin D, the CTX levels increased to comparable levels in controls (0.99 +- 0.57 ng/ml), and those of OPG decreased to levels that did not differ from controls (4.9 +- 5.1 pmol/L).	Vitamin D	6-15	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	21-24
30624776-0	2019	A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls.	Vitamin D	41-50	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	13-19
30624776-0	2019	A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls.	Vitamin D	98-107	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	13-19
30624776-12	2019	CONCLUSION: Based on our findings, it appears that the rs10741657 variant of the CYP2R1 gene modulates the response to high-dose of vitamin D supplementation.	Vitamin D	132-141	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	81-87
33036796-1	2021	OBJECTIVE: To study whether vitamin D (VitD) inhibits cell proliferation and Wnt/beta-catenin and transforming growth factor-beta (TGFbeta) signaling pathways in uterine leiomyomas independent of mediator complex subunit 12 (MED12) mutation status.	Vitamin D	28-37	catenin beta 1	Homo sapiens	81-93
30683615-5	2019	Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency.	Vitamin D	160-169	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	72-78
33058307-3	2021	METHODS: By using quantitative real-time polymerase chain reaction (qRT-PCR), we analyzed the expression ratio of CYP2R1, CYP27A1 and CYP27B1 genes within the vitamin D metabolic pathway in a total of 75 colorectal cancer (CRC) tissues compared to the adjacent tissues.	Vitamin D	159-168	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	114-120
30731172-8	2019	Topical steroids alone or in combination with topical vitamin D analogues were suggested for nail psoriasis limited to the nail bed.	Vitamin D	54-63	CD244 molecule	Homo sapiens	93-97
33058307-3	2021	METHODS: By using quantitative real-time polymerase chain reaction (qRT-PCR), we analyzed the expression ratio of CYP2R1, CYP27A1 and CYP27B1 genes within the vitamin D metabolic pathway in a total of 75 colorectal cancer (CRC) tissues compared to the adjacent tissues.	Vitamin D	159-168	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	122-129
30731172-8	2019	Topical steroids alone or in combination with topical vitamin D analogues were suggested for nail psoriasis limited to the nail bed.	Vitamin D	54-63	CD244 molecule	Homo sapiens	123-127
33325123-0	2021	Vitamin D rescues pancreatic beta cell dysfunction due to iron overload via elevation of the vitamin D receptor and maintenance of Ca2+ homeostasis.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	93-111
30830987-8	2019	BRD4 plays a critical role in histone modification and gene transcription, and cDNA expression profiling, using kidneys from Brd4+/M149T and Brd4+/+ mice, revealed differential expression of genes involved in vitamin D metabolism, cell differentiation, and apoptosis.	Vitamin D	209-218	bromodomain containing 4	Mus musculus	0-4
30830987-8	2019	BRD4 plays a critical role in histone modification and gene transcription, and cDNA expression profiling, using kidneys from Brd4+/M149T and Brd4+/+ mice, revealed differential expression of genes involved in vitamin D metabolism, cell differentiation, and apoptosis.	Vitamin D	209-218	bromodomain containing 4	Mus musculus	125-129
30830987-8	2019	BRD4 plays a critical role in histone modification and gene transcription, and cDNA expression profiling, using kidneys from Brd4+/M149T and Brd4+/+ mice, revealed differential expression of genes involved in vitamin D metabolism, cell differentiation, and apoptosis.	Vitamin D	209-218	bromodomain containing 4	Mus musculus	141-145
33486191-5	2021	We previously reported that treatment of mice with the active vitamin D analogue ED71, also known as eldecalcitol, inhibited HIF1alpha accumulation in osteoclasts.	Vitamin D	62-71	hypoxia inducible factor 1, alpha subunit	Mus musculus	125-134
30867220-0	2019	Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.	Vitamin D	97-106	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	13-34
30867220-0	2019	Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer.	Vitamin D	97-106	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	36-43
30867220-3	2019	We hypothesized that low CYP27A1 expression is associated with high cholesterol synthesis, low vitamin D signaling, and higher risk of lethal prostate cancer.	Vitamin D	95-104	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	25-32
33519717-0	2020	Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health.	Vitamin D	20-29	resistin	Homo sapiens	34-42
30668811-0	2019	Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer.	Vitamin D	0-9	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	19-26
33519717-3	2020	This study aimed to investigate the association between vitamin D and serum resistin levels in postmenopausal non-osteoporotic and osteoporotic females.	Vitamin D	56-65	resistin	Homo sapiens	76-84
30659895-8	2019	RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels.	Vitamin D	9-13	collagen type III alpha 1 chain	Homo sapiens	147-153
33519717-11	2020	There was a significant negative correlation between serum resistin and vitamin D in postmenopausal females (rho = -0.182, p = 0.021) and osteoporotic group (rho = -0.253, p = 0.019) but non-significant in non-osteoporotic group (rho = -0.077, p = 0.509).	Vitamin D	72-81	resistin	Homo sapiens	59-67
33519717-12	2020	Serum vitamin D was found to be independent predictor of serum resistin levels, accounting for only 3% variance.	Vitamin D	6-15	resistin	Homo sapiens	63-71
33519717-13	2020	Conclusion: Serum vitamin D levels were low while serum resistin levels were high in postmenopausal osteoporotic females and vitamin D is a negative predictor of serum resistin levels.	Vitamin D	125-134	resistin	Homo sapiens	168-176
33291213-6	2020	In addition, vitamin D treatments within in vitro cell lines have observed a reduced C-MYC expression and increased retinoblastoma protein levels that also result in G1/G0 arrest.	Vitamin D	13-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-90
30997352-0	2019	Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C. Background and Objective: Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states.	Vitamin D	50-59	hepcidin antimicrobial peptide	Homo sapiens	133-141
30997352-6	2019	Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = -0.37).	Vitamin D	223-232	hepcidin antimicrobial peptide	Homo sapiens	6-14
32736831-0	2020	Nutritional Quality"s Key Role in the Odds of Overweight in Adults with rs9939609 Polymorphism of FTO Gene- the Role of Manganese and Vitamin D.	Vitamin D	134-143	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	98-101
30616171-3	2019	The treatment with 100 ng/mL vitamin D remarkably reduced the thickness of the airway smooth muscle, collagen deposition, and the alpha-smooth muscle actin (alpha-SMA) mass and airway inflammation.	Vitamin D	29-38	actin gamma 2, smooth muscle	Rattus norvegicus	157-166
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	34-43	catenin beta 1	Rattus norvegicus	67-79
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	34-43	Wnt family member 2	Rattus norvegicus	57-60
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	34-43	catenin beta 1	Rattus norvegicus	298-310
32736831-11	2020	CONCLUSIONS: Intake of vitamin D from sunlight and its nutritional sources and adequate intake of Mn from a wide range of vegetables, legumes, seeds, and grains might be solutions for some overweight cases with FTO rs9939609 polymorphism.	Vitamin D	23-32	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	211-214
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	244-253	catenin beta 1	Rattus norvegicus	67-79
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	244-253	Wnt family member 2	Rattus norvegicus	57-60
32947396-9	2020	In the presence of Notch blocker LY-411575, RES could not restore VDR expression or secreted vitamin D levels in HCE-T cells exposed to hyperosmolar conditions, whereas recombinant Jagged1 restored vitamin D and VDR levels.	Vitamin D	198-207	jagged canonical Notch ligand 1	Homo sapiens	181-188
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	244-253	catenin beta 1	Rattus norvegicus	298-310
30616171-6	2019	These results suggested that administration of vitamin D alleviated the airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	47-56	Wnt family member 2	Rattus norvegicus	135-138
30616171-6	2019	These results suggested that administration of vitamin D alleviated the airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	47-56	catenin beta 1	Rattus norvegicus	139-151
30465855-1	2019	Vitamin D and TGF-beta exert opposite effects on epithelial-mesenchymal EMT transition.	Vitamin D	0-9	IL2 inducible T cell kinase	Homo sapiens	72-75
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	IL2 inducible T cell kinase	Homo sapiens	156-159
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	IL2 inducible T cell kinase	Homo sapiens	342-345
33227961-5	2020	Here we review the mechanisms by which 1,25(OH)2D3 inhibits Wnt/beta-catenin signaling and, conversely, how the activated Wnt/beta-catenin pathway may abrogate vitamin D action.	Vitamin D	160-169	catenin beta 1	Homo sapiens	126-138
30777056-0	2019	A genetic variant of CYP2R1 identified in a cat with type 1B vitamin D-dependent rickets: a case report.	Vitamin D	61-70	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	21-27
30777056-7	2019	Examination of the DNA sequences of CYP2R1 and CYP27B1 genes, which are genes linked with vitamin D metabolism, showed a CYP2R1 frameshift mutation in exon 5 (where T is deleted at position c.1386).	Vitamin D	90-99	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	36-42
30777056-7	2019	Examination of the DNA sequences of CYP2R1 and CYP27B1 genes, which are genes linked with vitamin D metabolism, showed a CYP2R1 frameshift mutation in exon 5 (where T is deleted at position c.1386).	Vitamin D	90-99	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	121-127
30777056-10	2019	CONCLUSIONS: To the best of our knowledge, the present case is the first description of type 1B vitamin D-dependent rickets linked with a genetic variant of CYP2R1 in a cat.	Vitamin D	96-105	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	157-163
30792871-0	2019	A novel PHEX mutation associated with vitamin D-resistant rickets.	Vitamin D	38-47	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	8-12
30597484-1	2019	Background: Sodium-glucose cotransporter-2 inhibitors promote glycosuria, resulting in possible effects on calcium, phosphate, and vitamin D homeostasis.	Vitamin D	131-140	solute carrier family 5 member 2	Homo sapiens	12-42
30733856-0	2019	Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/beta-catenin and other signal transduction pathways.	Vitamin D	70-79	catenin beta 1	Homo sapiens	119-131
28825325-0	2019	Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	56-59
30594355-8	2019	Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status.	Vitamin D	54-63	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Bos taurus	89-96
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	84-93	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	134-141
30723466-0	2019	Vitamin D Is Required for ILC3 Derived IL-22 and Protection From Citrobacter rodentium Infection.	Vitamin D	0-9	interleukin 22	Mus musculus	39-44
30723466-10	2019	IL-22 treatment of D- WT mice eliminated the need for vitamin D to clear the C. rodentium infection.	Vitamin D	54-63	interleukin 22	Mus musculus	0-5
33227961-6	2020	The available data suggest that interaction between Wnt/beta-catenin signaling and the vitamin D system is at the crossroads in solid cancers and may have therapeutic applications.	Vitamin D	87-96	catenin beta 1	Homo sapiens	56-68
33239907-1	2020	Purpose: Although the explanation for inconsistencies in the reported association between serum 25-hydroxyvitamin D [25(OH)D] levels and chronic pain (CP) has not yet been determined, understanding this discrepancy is necessary for the development of vitamin D supplementation as an effective treatment for CP.	Vitamin D	106-115	ceruloplasmin	Homo sapiens	151-153
33330279-14	2020	Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role.	Vitamin D	209-218	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	345-351
33304315-7	2020	Thereby, our data provide evidence of a modulatory effect of vitamin D in context of genetic variances in the Vra4 locus/Mhc2ta gene in MS-like neuroinflammation, with potential relevance for the human demyelinating disease.	Vitamin D	61-70	class II major histocompatibility complex transactivator	Homo sapiens	121-127
33038456-10	2020	The results of the multiple linear regression analysis indicate that vitamin D and HOMA are independent factors that significantly affect leptin and adiponectin levels, contrary to VAI.	Vitamin D	69-78	leptin	Homo sapiens	138-144
33064344-5	2021	RESULTS: Using a knock-in GFP reporter for the expression of the vitamin D target gene and negative regulator cyp24a1, we identified active vitamin D signaling in adult zebrafish fins during tissue homeostasis and regeneration.	Vitamin D	140-149	cytochrome P450, family 24, subfamily A, polypeptide 1	Danio rerio	110-117
32681429-4	2020	It is known that several androgen-metabolizing P450s (CYP3A4/5/43 and CYP2B6) and P450 enzymes (CYP2R1, CYP27A1, CYP27B1, CYP24A1, CYP3A4, CYP2J2), which are necessary for vitamin D metabolism, are expressed in the prostate.	Vitamin D	172-181	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	96-102
32681429-4	2020	It is known that several androgen-metabolizing P450s (CYP3A4/5/43 and CYP2B6) and P450 enzymes (CYP2R1, CYP27A1, CYP27B1, CYP24A1, CYP3A4, CYP2J2), which are necessary for vitamin D metabolism, are expressed in the prostate.	Vitamin D	172-181	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	104-111
32344004-1	2020	Mutations in CYP2R1 and CYP27A1 involved in the conversion of Cholecalciferol into Calcidiol were associated with the impaired 25-hydroxylase activity therefore affecting the Vitamin D metabolism.	Vitamin D	175-184	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	13-19
32344004-1	2020	Mutations in CYP2R1 and CYP27A1 involved in the conversion of Cholecalciferol into Calcidiol were associated with the impaired 25-hydroxylase activity therefore affecting the Vitamin D metabolism.	Vitamin D	175-184	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	24-31
32715032-3	2020	We recently suggested that the mediating mechanism may be a down-regulation of the vitamin D co-activator heat-shock protein (Hsp)90beta.	Vitamin D	83-92	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-136
32325367-0	2020	Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin.	Vitamin D	82-91	leptin	Homo sapiens	132-138
32314188-0	2020	Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling.	Vitamin D	0-9	signal transducer and activator of transcription 6	Homo sapiens	89-95
32314188-2	2020	The aim of this study was to determine whether vitamin D, which regulates the integrity of the epithelial barrier by expressing TJ proteins, reduces claudin-2 (Cl-2) levels by inhibiting Stat-6 phosphorylation and whether it increases claudin-4 (Cl-4) levels by blocking Smad-7 activity.	Vitamin D	47-56	signal transducer and activator of transcription 6	Homo sapiens	187-193
32314188-10	2020	CONCLUSIONS: Our results indicate that the effects of vitamin D on Cl-2 and Cl-4 are mediated by p-Stat-6 and Smad-7 signal, respectively.	Vitamin D	54-63	signal transducer and activator of transcription 6	Homo sapiens	99-105
32323557-8	2020	RESULTS: The average number of positive cells for caspases 2 and 3 were less in vitamin D group (P = .006 and P < .001, respectively).	Vitamin D	80-89	caspase 2	Homo sapiens	50-66
32555299-6	2020	Serum hepcidin level was correlated with the serum 25-hydroxy vitamin D level, which was in turn positively related to the femoral Z score.	Vitamin D	62-71	hepcidin antimicrobial peptide	Homo sapiens	6-14
32512862-4	2020	On multivariate analyses adjusting serum 25-hydroxyvitamin D, vitamin D supplementation, sarcopenia, body mass index, age, sex, cancer loci, stage, and adjuvant chemotherapy, patients with SPARC levels lower than the median level had a significantly higher risk for death than those with higher levels (hazard ratio, 2.25; 95% confidence interval, 1.25-4.05; p = 0.007), whereas there were no significant associations with other outcomes including recurrence.	Vitamin D	51-60	secreted protein acidic and cysteine rich	Homo sapiens	189-194
32517587-11	2020	The SNP frequency in CYP2R1 (rs10741657) and DBP (rs2282679) in the vitamin D deficient group was significantly higher than in the control group (p-values < 0.001 and 0.01 respectively).	Vitamin D	68-77	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	21-27
32020783-8	2020	RESULTS: In activity-limited mice, vitamin D deficiency accelerated the decrease in GA muscle weight, muscle fiber CSA, and grip strength and increased the protein expression of MuRF1, MAFbx, and FOXO3a (all P &lt; 0.05).	Vitamin D	35-44	F-box protein 32	Mus musculus	185-190
30723466-11	2019	Vitamin D is required for early IL-22 production from ILC3 cells and protection from enteric infection with C. rodentium.	Vitamin D	0-9	interleukin 22	Mus musculus	32-37
32228128-12	2020	CONCLUSION: The association between IL-1beta rs16944 genotype and CXCL10 levels was modified by the levels of ascorbic acid, alpha-tocopherol and vitamin D.	Vitamin D	146-155	interleukin 1 alpha	Homo sapiens	36-44
30285234-0	2019	The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to vitamin D.	Vitamin D	136-145	interferon regulatory factor 8	Homo sapiens	63-67
30285234-4	2019	We show these genes are responsive to vitamin D: ZMIZ1 expression increased and IRF8 expression decreased, and this response was affected by genotype in different cell subsets.	Vitamin D	38-47	interferon regulatory factor 8	Homo sapiens	80-84
30285234-6	2019	These data indicate that vitamin D regulation of ZMIZ1 and IRF8 in DCs and monocytes contribute to latitude-dependent autoimmune disease risk.	Vitamin D	25-34	interferon regulatory factor 8	Homo sapiens	59-63
32481491-4	2020	While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting.	Vitamin D	42-51	anti-Mullerian hormone	Homo sapiens	110-113
30881469-11	2019	This suggests that glucose stimulated insulin secretion in INS1E beta cells appears to be related to the type of vitamin D metabolite treatment.	Vitamin D	113-122	insulin 1	Rattus norvegicus	59-63
32481491-6	2020	The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH.	Vitamin D	119-128	anti-Mullerian hormone	Homo sapiens	133-136
30246883-7	2019	RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group.	Vitamin D	9-18	C-C motif chemokine ligand 2	Homo sapiens	147-152
30246883-7	2019	RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group.	Vitamin D	9-18	interleukin 1 alpha	Homo sapiens	165-173
30246883-7	2019	RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group.	Vitamin D	9-18	toll like receptor 4	Homo sapiens	189-194
30246883-10	2019	CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease.	Vitamin D	28-37	C-C motif chemokine ligand 2	Homo sapiens	159-164
30246883-10	2019	CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease.	Vitamin D	68-77	C-C motif chemokine ligand 2	Homo sapiens	159-164
32481491-8	2020	Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH.	Vitamin D	105-114	anti-Mullerian hormone	Homo sapiens	119-122
32481491-9	2020	However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman"s ovulatory status.	Vitamin D	95-104	anti-Mullerian hormone	Homo sapiens	130-133
31210105-8	2019	CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-gamma, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes.	Vitamin D	80-89	insulin receptor substrate 1	Homo sapiens	187-191
31210105-8	2019	CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-gamma, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes.	Vitamin D	80-89	low density lipoprotein receptor	Homo sapiens	268-272
32481491-9	2020	However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman"s ovulatory status.	Vitamin D	95-104	anti-Mullerian hormone	Homo sapiens	201-204
30584976-10	2019	RESULTS: BDNF level increased while c-fos, Bax and caspase-3 levels decreased (p &lt; 0.0001, in all) in the hippocampal neurons of the groups that were pre-treated with vitamin D before the administration of PTZ and KA, in comparison with the PTZ and KA groups.	Vitamin D	170-179	BCL2 associated X, apoptosis regulator	Rattus norvegicus	43-46
32481491-9	2020	However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman"s ovulatory status.	Vitamin D	187-196	anti-Mullerian hormone	Homo sapiens	130-133
31016149-10	2019	Conclusions: Vitamin D supplementation in VDD children resulted in decrease in both bone formation (P1NP) and resorption (CTx).	Vitamin D	13-22	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	122-125
32481491-9	2020	However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman"s ovulatory status.	Vitamin D	187-196	anti-Mullerian hormone	Homo sapiens	201-204
32481491-10	2020	Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) -0.53, 95% CI -0.91 to -0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003).	Vitamin D	48-57	anti-Mullerian hormone	Homo sapiens	6-9
32393583-0	2020	Vitamin D supplementation rescues aberrant NF-kappaB pathway activation and partially ameliorates Rett syndrome phenotypes in Mecp2 mutant mice.	Vitamin D	0-9	methyl CpG binding protein 2	Mus musculus	126-131
30456544-9	2019	On stepwise multiple regression analysis, only E-selectin was associated with vitamin D levels (beta = - 0.324; p = 0.002).	Vitamin D	78-87	selectin E	Homo sapiens	47-57
30456544-10	2019	CONCLUSION: Vitamin D deficiency was common in kidney transplant recipients in North India, associated with low FGF23 and high E-selectin.	Vitamin D	12-21	selectin E	Homo sapiens	127-137
32393583-3	2020	Here, we investigate whether the known NF-kappaB pathway inhibitor vitamin D ameliorates neuronal phenotypes in Mecp2-mutant mice.	Vitamin D	67-76	methyl CpG binding protein 2	Mus musculus	112-117
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	17-26	methyl CpG binding protein 2	Mus musculus	106-111
29936100-5	2019	RESULTS: DEP and allergen coexposure resulted in increased airway hyperresponsiveness (AHR) and accumulation of pathogenic TH2/TH17 cells in the lungs of vitamin D-deficient mice compared with control mice.	Vitamin D	154-163	heart and neural crest derivatives expressed 2	Mus musculus	123-126
29936100-6	2019	Prenatal and postnatal vitamin D supplementation significantly attenuated the development of AHR and decreased pulmonary accumulation of TH2/TH17 cells after coexposure to TRAP and allergen but not to allergen alone.	Vitamin D	23-32	heart and neural crest derivatives expressed 2	Mus musculus	137-140
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	17-26	methyl CpG binding protein 2	Mus musculus	222-227
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	17-26	methyl CpG binding protein 2	Mus musculus	222-227
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	17-26	methyl CpG binding protein 2	Mus musculus	222-227
30137362-3	2019	Furthermore, vitamin D receptor (VDR) and vitamin D-metabolizing enzymes [cytochrome 450 (CYP)] expression in adipose tissue (AT) might affect AT insulin sensitivity.	Vitamin D	13-22	peptidylprolyl isomerase G	Homo sapiens	90-93
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	186-195	methyl CpG binding protein 2	Mus musculus	106-111
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	186-195	methyl CpG binding protein 2	Mus musculus	222-227
30879014-0	2019	Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-gamma/HO-1 Pathway.	Vitamin D	0-9	heme oxygenase 1	Homo sapiens	105-109
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	186-195	methyl CpG binding protein 2	Mus musculus	222-227
30879014-9	2019	These findings also suggest that vitamin D protected EPCs from AngII-induced vascular injury via the activation of the PPAR-gamma/HO-1 signaling pathway.	Vitamin D	33-42	heme oxygenase 1	Homo sapiens	130-134
32393583-5	2020	We identify that vitamin D rescues aberrant NF-kappaB pathway activation and reduced neurite outgrowth of Mecp2 knockdown cortical neurons in vitro Further, dietary supplementation with vitamin D in early symptomatic male Mecp2 hemizygous null and female Mecp2 heterozygous mice ameliorates reduced neocortical dendritic morphology and soma size phenotypes, and modestly improves reduced lifespan of Mecp2-nulls.	Vitamin D	186-195	methyl CpG binding protein 2	Mus musculus	222-227
32393583-9	2020	Here, we identify that the known NF-kappaB inhibitor vitamin D reduces the aberrant NF-kappaB signaling in Mecp2 knockdown neurons, and partially ameliorates neuronal size and complexity phenotypes in both male and female Mecp2-mutant mice.	Vitamin D	53-62	methyl CpG binding protein 2	Mus musculus	107-112
30120973-0	2018	Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis.	Vitamin D	35-44	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	11-17
32393583-9	2020	Here, we identify that the known NF-kappaB inhibitor vitamin D reduces the aberrant NF-kappaB signaling in Mecp2 knockdown neurons, and partially ameliorates neuronal size and complexity phenotypes in both male and female Mecp2-mutant mice.	Vitamin D	53-62	methyl CpG binding protein 2	Mus musculus	222-227
30120973-1	2018	BACKGROUND AND OBJECTIVE: CYP2R1 is a key gene in the vitamin D metabolic pathway.	Vitamin D	54-63	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	26-32
30120973-2	2018	It has been suggested that CYP2R1 gene variants in European populations are associated with concentrations of 25(OH)D, a biomarker of vitamin D levels and status in peripheral blood.	Vitamin D	134-143	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	27-33
32115644-0	2020	Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis.	Vitamin D	91-100	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	26-32
30120973-4	2018	The objective of this meta-analysis was to evaluate the association between CYP2R1 gene variants and 25(OH)D levels and vitamin D status.	Vitamin D	120-129	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	76-82
30120973-16	2018	CONCLUSION: Published articles provide evidence supporting a major role for the rs10741657 polymorphism of the CYP2R1 gene in determining 25(OH)D levels and the presence of vitamin D deficiency.	Vitamin D	173-182	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	111-117
31783150-2	2020	The active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D), regulates myeloid cell biology and previous research showed that in mouse models 1,25(OH)2D reduced the tumor level of CD34+ cells, an MDSC precursor, and reduced metastasis.	Vitamin D	19-28	CD34 antigen	Mus musculus	187-191
30314996-0	2018	Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/beta-catenin signaling.	Vitamin D	0-9	catenin beta 1	Homo sapiens	121-133
30314996-16	2018	Vitamin D-induced VDR expression increased the sensitivity of MCF-7 stem cells to tamoxifen by inhibiting Wnt/beta-catenin signaling.	Vitamin D	0-9	catenin beta 1	Homo sapiens	110-122
31721480-10	2020	Repletion of vitamin D partially or fully normalized food intake, weight gain, gain of fat, and lean mass, improved energy homeostasis, and attenuated perturbations of uncoupling proteins and adenosine triphosphate content in adipose tissue and muscle in Ctns-/- mice.	Vitamin D	13-22	cystinosis, nephropathic	Mus musculus	255-259
31721480-11	2020	Vitamin D repletion attenuated elevated expression of beige adipose cell biomarkers (UCP-1, CD137, Tmem26, and Tbx1) as well as aberrant expression of molecules implicated in adipose tissue browning (Cox2, Pgf2alpha, and NF-kappaB pathway) in inguinal white adipose tissue in Ctns-/- mice.	Vitamin D	0-9	T-box 1	Mus musculus	111-115
30526863-0	2018	Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.	Vitamin D	73-82	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	45-51
31721480-11	2020	Vitamin D repletion attenuated elevated expression of beige adipose cell biomarkers (UCP-1, CD137, Tmem26, and Tbx1) as well as aberrant expression of molecules implicated in adipose tissue browning (Cox2, Pgf2alpha, and NF-kappaB pathway) in inguinal white adipose tissue in Ctns-/- mice.	Vitamin D	0-9	cystinosis, nephropathic	Mus musculus	276-280
29308676-0	2018	Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin-angiotensin inhibition.	Vitamin D	0-9	Klotho	Rattus norvegicus	78-84
29308676-4	2018	Vitamin D caused more reduction in monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGFbeta-1), and renin-angiotensin levels that gave better kidney function compared to the DM + L group.	Vitamin D	0-9	C-C motif chemokine ligand 2	Rattus norvegicus	35-69
31721480-12	2020	Vitamin D repletion normalized skeletal muscle fibre size and improved in vivo muscle function in Ctns-/- mice.	Vitamin D	0-9	cystinosis, nephropathic	Mus musculus	98-102
29308676-5	2018	CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.	Vitamin D	12-21	vitamin D receptor	Rattus norvegicus	124-127
31721480-17	2020	Mechanistically, vitamin D repletion attenuates adipose tissue browning and muscle wasting in Ctns-/- mice via multiple cellular and molecular mechanisms.	Vitamin D	17-26	cystinosis, nephropathic	Mus musculus	94-98
29308676-5	2018	CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.	Vitamin D	12-21	Klotho	Rattus norvegicus	129-135
29308676-5	2018	CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.	Vitamin D	182-191	vitamin D receptor	Rattus norvegicus	124-127
31756344-0	2020	Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.	Vitamin D	7-16	transformation related protein 53, pseudogene	Mus musculus	125-128
32918225-4	2020	Interestingly, a crosstalk between vitamin D and p53 signaling has been demonstrated that occurs at different levels, has genome-wide implications, and is of high importance for many malignancies, including non-melanoma skin cancer.	Vitamin D	35-44	transformation related protein 53, pseudogene	Mus musculus	49-52
30072546-0	2018	Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources.	Vitamin D	48-57	insulin like growth factor binding protein 3	Homo sapiens	62-69
30072546-2	2018	Preclinical studies found that vitamin D regulates IGFBP-3 expression, although evidence from epidemiologic studies is conflicting.	Vitamin D	31-40	insulin like growth factor binding protein 3	Homo sapiens	51-58
30072546-4	2018	Observational and MR analyses were conducted to assess the relationship between inactive vitamin D [25(OH)D] and IGFBP-3 using data from the ProtecT study (1,366 cases;1,071 controls) and summary statistics from the CHARGE consortium (n = 18,995).	Vitamin D	89-98	insulin like growth factor binding protein 3	Homo sapiens	113-120
32918225-9	2020	A third level of interaction is documented by the ability of vitamin D compounds to regulate the expression of the murine double minute (MDM2) gene in dependence of the presence of wild-type p53.	Vitamin D	61-70	transformed mouse 3T3 cell double minute 2	Mus musculus	137-141
32918225-9	2020	A third level of interaction is documented by the ability of vitamin D compounds to regulate the expression of the murine double minute (MDM2) gene in dependence of the presence of wild-type p53.	Vitamin D	61-70	transformation related protein 53, pseudogene	Mus musculus	191-194
33164936-9	2020	Leukocyte TL was significantly higher, while serum 8-OXO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p <  0.001).	Vitamin D	122-131	8-oxoguanine DNA glycosylase	Homo sapiens	61-65
31866999-8	2019	In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion.	Vitamin D	13-22	interleukin 1 alpha	Homo sapiens	108-116
31690667-9	2019	In vitro functional validation studies showed that elevated vitamin D-VDR signaling inhibited Wnt/beta-catenin signaling genes.	Vitamin D	60-69	catenin beta 1	Homo sapiens	98-110
31470109-0	2019	UV increases skin-derived 1alpha,25-dihydroxyvitamin D3 production, leading to MMP-1 expression by altering the balance of vitamin D and cholesterol synthesis from 7-dehydrocholesterol.	Vitamin D	45-54	matrix metallopeptidase 1	Homo sapiens	79-84
31470109-2	2019	Keratinocytes express both 25-hydroxylase (CYP27A1 and CYP2R1) and 1alpha-hydroxylase (CYP27B1), critical enzymes involved in active vitamin D synthesis.	Vitamin D	133-142	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	43-50
31470109-2	2019	Keratinocytes express both 25-hydroxylase (CYP27A1 and CYP2R1) and 1alpha-hydroxylase (CYP27B1), critical enzymes involved in active vitamin D synthesis.	Vitamin D	133-142	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	55-61
31702812-6	2019	In addition, the levels of IL-4, IL-6 and IL-10 in the BMDCs from the vitamin D-deficient mice were significantly decreased compared with the control mice, while the levels of tumor necrosis factor-alpha, IL-5, IL-2, IL-12 and interferon-gamma were significantly increased.	Vitamin D	70-79	interleukin 4	Mus musculus	27-31
31824492-6	2019	Activating the CAMP pathway using Vitamin D in hMDM1 resulted in a cathelicidin-mediated-Leishmania restriction.	Vitamin D	34-43	Mdm1 nuclear protein	Homo sapiens	47-52
31430707-1	2019	BACKGROUND: Although modulation of the vitamin D receptor (VDR) and endothelin-A receptor (ETAR) has previously been reported to offer renoprotection against cisplatin-induced nephrotoxicity, the possible interaction between the ET-1 and vitamin D pathways remains obscure.	Vitamin D	39-48	vitamin D receptor	Rattus norvegicus	59-62
30840757-0	2019	Vitamin D Decreases Hepcidin and Inflammatory Markers in Newly Diagnosed Inflammatory Bowel Disease Pediatric Patients- A Prospective Study.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	20-28
30840757-2	2019	However, it has been shown that vitamin D suppresses hepcidin expression.	Vitamin D	32-41	hepcidin antimicrobial peptide	Homo sapiens	53-61
30840757-11	2019	Following vitamin D treatment serum hepcidin concentration decreased significantly.	Vitamin D	10-19	hepcidin antimicrobial peptide	Homo sapiens	36-44
31524100-7	2021	Results: Vitamin D supplementation significantly mitigated the observed aging-related reduction in brain BDNF level and activities of AChE and antioxidant enzymes and elevation in malondialdehyde level and caspase-3 activity compared to control groups.	Vitamin D	9-18	acetylcholinesterase	Rattus norvegicus	134-138
31583252-5	2019	Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients.	Vitamin D	172-181	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	110-116
31245891-0	2019	Vitamin D attenuates myocardial ischemia-reperfusion injury by inhibiting inflammation via suppressing the RhoA/ROCK/NF-kB pathway.	Vitamin D	0-9	nuclear factor kappa B subunit 1	Rattus norvegicus	117-122
30993743-1	2019	BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D.	Vitamin D	87-96	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	149-155
30993743-3	2019	We aimed at investigating the family-based association between SNPs of CYP2R1 and CYP27B1 and vitamin D deficiency.	Vitamin D	94-103	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	71-77
31207920-8	2019	Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D.	Vitamin D	238-247	angiopoietin like 4	Homo sapiens	10-18
31163658-1	2019	Deficiency in vitamin D (Vit D) has been widely associated with several musculoskeletal diseases.	Vitamin D	14-23	vitrin	Rattus norvegicus	25-28
30661440-6	2019	Increased MAP1LC3B/LC3 expression corroborated with complete autolysosome formation detected by electron microscopy and correlated with degradation of SQSTM1/p62 in the skin following vitamin D treatment.	Vitamin D	184-193	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	14-17
31001917-0	2019	Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.	Vitamin D	14-23	UDP glucuronosyltransferase family 2 member A1 complex locus	Homo sapiens	70-78
30889441-5	2019	The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis.	Vitamin D	104-113	tensin 2	Mus musculus	45-48
30889441-5	2019	The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis.	Vitamin D	104-113	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	53-58
30508644-0	2019	Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen.	Vitamin D	17-26	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	57-61
30184270-6	2018	In addition, the CYP1A1 gene, responsible for the hydroxylation of 17beta-estradiol, estrone, and vitamin D, was also mutated in all three sisters and one unrelated patient.	Vitamin D	98-107	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	17-23
30167938-0	2019	Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes.	Vitamin D	0-9	monoamine oxidase A	Homo sapiens	51-70
30206310-0	2018	Vitamin D protects human melanocytes against oxidative damage by activation of Wnt/beta-catenin signaling.	Vitamin D	0-9	catenin beta 1	Homo sapiens	83-95
30206310-7	2018	Using ex vivo cell models, we further showed that vitamin D positively modulated beta-catenin signaling at both translational and posttranslational levels in melanocytes under oxidative stress.	Vitamin D	50-59	catenin beta 1	Homo sapiens	81-93
30206310-8	2018	Like WNT agonists, vitamin D significantly inhibited ROS accumulation and cell apoptosis in H2O2-treated melanocytes and promoted their proliferative and migratory activity, while the protective effects of vitamin D against oxidative stress were abolished by beta-catenin silencing in melanocytes.	Vitamin D	19-28	catenin beta 1	Homo sapiens	259-271
30167938-8	2019	Vitamin D significantly improved vascular function, mitigated oxidative stress and decreased MAO-A expression in diabetic vascular preparations.	Vitamin D	0-9	monoamine oxidase A	Homo sapiens	93-98
30206310-9	2018	Furthermore, beta-catenin deficiency also blocked the activation of Nrf2 and MITF as well as the inhibition of apoptosis induced by vitamin D.	Vitamin D	132-141	catenin beta 1	Homo sapiens	13-25
30167938-9	2019	In conclusion, MAO-A is induced in diabetic aortas and vitamin D can improve diabetes-induced endothelial dysfunction by modulating the MAO-A expression.	Vitamin D	55-64	monoamine oxidase A	Homo sapiens	136-141
30206310-11	2018	Our work also provides new insights into the mechanism of vitamin D against vitiligo, in which vitamin D protects melanocytes against oxidative stress by activating Wnt/beta-catenin signaling.	Vitamin D	58-67	catenin beta 1	Homo sapiens	169-181
30206310-11	2018	Our work also provides new insights into the mechanism of vitamin D against vitiligo, in which vitamin D protects melanocytes against oxidative stress by activating Wnt/beta-catenin signaling.	Vitamin D	95-104	catenin beta 1	Homo sapiens	169-181
30606768-2	2019	Vitamin D signaling regulates c-MYC expression and turnover in vitro and in vivo, which is highly significant as epidemiologic data link vitamin D deficiency to increased cancer incidence.	Vitamin D	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	30-35
30328681-0	2018	Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status.	Vitamin D	88-97	presenilin 1	Mus musculus	63-66
30606768-2	2019	Vitamin D signaling regulates c-MYC expression and turnover in vitro and in vivo, which is highly significant as epidemiologic data link vitamin D deficiency to increased cancer incidence.	Vitamin D	137-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	30-35
30515164-0	2018	Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D.	Vitamin D	181-190	lactotransferrin	Bos taurus	7-18
30791479-5	2019	The vitamin-D analogue, calcipotriol, induced increased expression of the neuronal vitamin D-dependent calcium-binding protein, calbindin-D28k, and this significantly decreased the occurrence of alpha-syn aggregates in cells with transiently raised intracellular free Ca, thereby increasing viability.	Vitamin D	4-13	synuclein alpha	Homo sapiens	195-204
30487754-3	2018	Therefore, we investigated the direct effects of VD3 at the specific preantral and antral stages of follicular development, and tested the hypothesis that vitamin D receptor (VDR) and enzymes critical for vitamin D biosynthesis are expressed in the primate ovary.	Vitamin D	155-164	vitamin D receptor	Macaca mulatta	175-178
30287151-5	2019	Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES).	Vitamin D	129-138	C-C motif chemokine ligand 2	Homo sapiens	407-441
28783999-7	2018	IL-2, Ig-A, and Ig-G levels are significant increased in the vitamin D supplementation group compared with the control group (p &lt; .05) (3).	Vitamin D	61-70	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	6-10
30287151-5	2019	Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES).	Vitamin D	129-138	C-C motif chemokine ligand 2	Homo sapiens	442-447
30760247-2	2019	Interleukin (IL)-15 and IL-32 play roles in the vitamin D-mediated tuberculosis (TB) defense mechanism.	Vitamin D	48-57	interleukin 32	Homo sapiens	24-29
29339180-0	2018	Leptin blocks the inhibitory effect of vitamin D on adipogenesis and cell proliferation in 3T3-L1 adipocytes.	Vitamin D	39-48	leptin	Mus musculus	0-6
30760247-13	2019	CONCLUSIONS: Our preliminary data showed that the levels of the vitamin D-related cytokines IL-15 and IL-32 differed between active TB patients and LTBI subjects.	Vitamin D	64-73	interleukin 32	Homo sapiens	102-107
30208925-7	2018	The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform.	Vitamin D	60-69	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	98-105
30458994-0	2019	Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/beta-catenin pathway.	Vitamin D	70-79	catenin beta 1	Homo sapiens	88-100
30208925-7	2018	The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform.	Vitamin D	60-69	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	116-122
30458994-1	2019	OBJECTIVE: To assess the effect of vitamin D (VitD) on human uterine leiomyomas through Wnt/beta-catenin pathway inhibition, apoptosis induction, and cell growth arrest.	Vitamin D	35-44	catenin beta 1	Homo sapiens	92-104
30088172-3	2018	The aim of our study was to investigate the association of SNPs in CYP27A1, CYP24A1, and RXR- alpha genes, vitamin D status, and MS risk.	Vitamin D	107-116	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	67-74
30522147-4	2019	In the present study, PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to September 2017 for trials that evaluated the effect of vitamin D supplementation on prostate specific antigen (PSA) response, mortality, and its possible side effects in participants with prostate cancer.	Vitamin D	152-161	kallikrein related peptidase 3	Homo sapiens	181-206
30522147-4	2019	In the present study, PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to September 2017 for trials that evaluated the effect of vitamin D supplementation on prostate specific antigen (PSA) response, mortality, and its possible side effects in participants with prostate cancer.	Vitamin D	152-161	kallikrein related peptidase 3	Homo sapiens	208-211
30270688-9	2018	A significant decrease during treatment with vitamin D was also observed for cytokeratin-18 fragments compared with placebo.	Vitamin D	45-54	keratin 18	Homo sapiens	77-91
30522147-8	2019	Single arm trials revealed that vitamin D supplementation had a modest effect on PSA response proportion: 19% of those enrolled had at least a 50% reduction in PSA by the end of treatment (95% CI: 7% to 31%; p=0.002).	Vitamin D	32-41	kallikrein related peptidase 3	Homo sapiens	81-84
30522147-8	2019	Single arm trials revealed that vitamin D supplementation had a modest effect on PSA response proportion: 19% of those enrolled had at least a 50% reduction in PSA by the end of treatment (95% CI: 7% to 31%; p=0.002).	Vitamin D	32-41	kallikrein related peptidase 3	Homo sapiens	160-163
30138371-5	2018	RESULTS: We identified three vitamin D associated genes that were differentially expressed between RA and non-RA patients: Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) (FC = 1.47; p = 0.006), Nuclear Receptor Co-repressor 1 (NCOR1) (FC = 1,21; p = 0.005) and paraoxonases 2 (PON2) (FC = -1.37; p = 0.01).	Vitamin D	29-38	nuclear receptor corepressor 1	Homo sapiens	213-244
30138371-5	2018	RESULTS: We identified three vitamin D associated genes that were differentially expressed between RA and non-RA patients: Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) (FC = 1.47; p = 0.006), Nuclear Receptor Co-repressor 1 (NCOR1) (FC = 1,21; p = 0.005) and paraoxonases 2 (PON2) (FC = -1.37; p = 0.01).	Vitamin D	29-38	nuclear receptor corepressor 1	Homo sapiens	246-251
30522147-9	2019	Although before-after studies showed that vitamin D increases the PSA response proportion, it does not seem that patients with prostate cancer benefit from high dose vitamin D supplementation and it should not be recommended for the treatment.	Vitamin D	42-51	kallikrein related peptidase 3	Homo sapiens	66-69
31266036-1	2019	BACKGROUND: Vitamin D (VD) was suggested to have both direct and indirect effects on modifying lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity.	Vitamin D	12-21	lipoprotein lipase	Homo sapiens	196-214
29795199-2	2018	Recently, it has been shown that vitamin D suppresses hepcidin expression.	Vitamin D	33-42	hepcidin antimicrobial peptide	Homo sapiens	54-62
29795199-3	2018	Our hypothesis was that hepcidin levels inversely correlate with vitamin D levels in anemic children during acute infection.	Vitamin D	65-74	hepcidin antimicrobial peptide	Homo sapiens	24-32
29947534-0	2018	Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice.	Vitamin D	0-9	endothelin 1	Mus musculus	22-34
29947534-0	2018	Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice.	Vitamin D	0-9	endothelin receptor type B	Mus musculus	36-40
29947534-0	2018	Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice.	Vitamin D	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	42-46
29947534-1	2018	We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO).	Vitamin D	85-94	endothelin 1	Mus musculus	32-36
29947534-1	2018	We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO).	Vitamin D	85-94	endothelin receptor type B	Mus musculus	37-41
29947534-1	2018	We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO).	Vitamin D	85-94	nitric oxide synthase 3, endothelial cell	Mus musculus	42-46
29947534-10	2018	Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions.	Vitamin D	0-9	endothelin 1	Mus musculus	35-39
29947534-10	2018	Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions.	Vitamin D	0-9	endothelin receptor type B	Mus musculus	41-45
29947534-10	2018	Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions.	Vitamin D	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	50-54
29947534-13	2018	Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression.	Vitamin D	0-9	endothelin 1	Mus musculus	109-113
29947534-13	2018	Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression.	Vitamin D	0-9	endothelin receptor type B	Mus musculus	114-118
29947534-13	2018	Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression.	Vitamin D	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	123-127
29930537-12	2018	Cholecalciferol prevented prednisolone-elicited disturbances of the RANKL/RANK/OPG, which correlated with improved bioavailability and vitamin D signaling through VDR.	Vitamin D	135-144	TNF receptor superfamily member 11B	Rattus norvegicus	79-82
29930537-14	2018	Our findings suggest that prednisolone-induced abnormalities in GR and RANKL/RANK/OPG signaling pathways are associated with the impairments of vitamin D auto/paracrine system in BM cells and can be ameliorated by cholecalciferol supplementation.	Vitamin D	144-153	TNF receptor superfamily member 11B	Rattus norvegicus	82-85
29355791-10	2018	Vitamin D replacement after VDD could partially restore the muscle volume, muscle fiber size, and intramyonuclear VDR concentration levels (p&lt;.05) of the paraspinal muscles.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	114-117
29355791-12	2018	Vitamin D replacement contributes to the recovery from atrophy and restoration of intramyonuclear VDR concentration in VDD status.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	98-101
29881333-5	2018	For vitamin D deficiency groups, OVA-specific IgE and IL-4 levels were significantly increased, while IFN-gamma levels were unchanged.	Vitamin D	4-13	interleukin 4	Mus musculus	54-58
29881333-6	2018	Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression of the tight junction protein between adjacent epithelial cells and the percentages of CD4+CD25+Foxp3+Treg cell in spleen and mesenteric lymph nodes.	Vitamin D	0-9	forkhead box P3	Mus musculus	202-207
29754817-0	2018	Vitamin D Switches BAF Complexes to Protect beta Cells.	Vitamin D	0-9	b-associated fitness	Mus musculus	19-22
29755836-12	2018	CONCLUSIONS: Vitamin D deficiency is associated with the degree of luminal stenosis and burden of CAD in women undergoing coronary angiography.	Vitamin D	13-22	aconitate decarboxylase 1	Homo sapiens	98-101
29229305-3	2018	The regulatory effects of vitamin D on Wnt/beta-catenin pathway were demonstrated by previous studies.	Vitamin D	26-35	catenin beta 1	Homo sapiens	43-55
29533337-0	2018	A Relationship Between Blood Levels of Otolin-1 and Vitamin D.	Vitamin D	52-61	otolin 1	Homo sapiens	39-47
29533337-2	2018	Since otoconia degeneration contributes to iBPPV and a lack of vitamin D may impact otoconia structure and integrity, we proposed a negative association between vitamin D levels and levels of a proposed circulatory biomarker for otolithic degeneration, otolin-1.	Vitamin D	161-170	otolin 1	Homo sapiens	253-261
29533337-11	2018	There was a negative correlation between vitamin D and otolin-1 levels of subjects over 70 (r = -0.36, p = 0.036).	Vitamin D	41-50	otolin 1	Homo sapiens	55-63
29533337-12	2018	CONCLUSION: Our results demonstrate a relationship between vitamin D and otolin-1.	Vitamin D	59-68	otolin 1	Homo sapiens	73-81
29470176-3	2018	However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD.	Vitamin D	177-186	insulin like growth factor binding protein 3	Homo sapiens	118-162
29470176-3	2018	However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD.	Vitamin D	177-186	insulin like growth factor binding protein 3	Homo sapiens	164-171
29470176-11	2018	The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D.	Vitamin D	85-94	insulin like growth factor binding protein 3	Homo sapiens	20-27
29568200-7	2018	In a larger cohort of patients and controls, a disease-associated expression pattern, with higher transcript levels in vitamin D-treated PBMCs from patients, was observed for three of these genes, CLEC5A (P &lt; 0.030), lysozyme (LYZ; P &lt; 0.047) and TREM1 (P &lt; 0.023).	Vitamin D	119-128	triggering receptor expressed on myeloid cells 1	Homo sapiens	253-258
29520786-9	2018	IL-8 and monocyte chemotactic protein-1 mRNA expression could be suppressed by the vitamin D pathway.	Vitamin D	83-92	C-C motif chemokine ligand 2	Homo sapiens	9-39
28870774-8	2018	In total, VDR sites with GABPA co-localization may control some 450 vitamin D target genes.	Vitamin D	68-77	GA binding protein transcription factor subunit alpha	Homo sapiens	25-30
29037825-0	2018	Vitamin D prevents lipid accumulation in murine muscle through regulation of PPARgamma and perilipin-2 expression.	Vitamin D	0-9	predicted gene 12551	Mus musculus	91-102
29469965-2	2018	Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Canis lupus familiaris	64-82
29469965-2	2018	Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Canis lupus familiaris	84-87
29426300-3	2018	Vitamin D was recently shown to reduce serum hepcidin concentrations in healthy individuals.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	45-53
29426300-14	2018	Future studies are needed to assess if nutritional forms of vitamin D affect hepcidin concentrations in CKD.	Vitamin D	60-69	hepcidin antimicrobial peptide	Homo sapiens	77-85
31902860-7	2019	The general linear and noncondition logistical regression model were employed to explore the association between vitamin D and both muscle mass and grip strength.	Vitamin D	113-122	glutamate receptor interacting protein 1	Homo sapiens	148-152
29018141-7	2018	In the presence of vitamin D, C-Ret mRNA and protein expression were increased.	Vitamin D	19-28	ret proto-oncogene	Homo sapiens	30-35
29018141-8	2018	The chromatin immunoprecipitation results suggested that C-Ret is directly regulated by vitamin D via VDR.	Vitamin D	88-97	ret proto-oncogene	Homo sapiens	57-62
29018141-12	2018	These data extend our knowledge of the diverse and important roles played by vitamin D in dopamine physiology.-Pertile, R. A. N., Cui, X., Hammond, L., Eyles, D. W. Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.	Vitamin D	165-174	ret proto-oncogene	Homo sapiens	194-197
29291611-15	2018	In addition, the expression of select IBS genetic biomarkers, including tryptophan hydroxylase 1, was modulated by vitamin D.	Vitamin D	115-124	tryptophan hydroxylase 1	Homo sapiens	72-96
29999169-0	2018	Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells.	Vitamin D	164-173	low density lipoprotein receptor-related protein 2	Mus musculus	129-136
29999169-0	2018	Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells.	Vitamin D	164-173	low density lipoprotein receptor-related protein 2	Mus musculus	129-136
29737807-7	2018	Vitamin D was highly correlated with DPN, DN, diabetes duration, age, sex, fasting plasma glucose, blood urea nitrogen, total cholesterol, low density lipoprotein cholesterol, 24-h urinary microalbumin, and beta-2 microglobulin (r=-0.34 ~ -0.133, p&lt;0.05).	Vitamin D	0-9	beta-2-microglobulin	Homo sapiens	207-227
29804528-0	2018	Genetic Variants of CYP2R1 Are Key Regulators of Serum Vitamin D Levels and Incidence of Myocardial Infarction in Middle-Aged Egyptians.	Vitamin D	55-64	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	20-26
29804528-5	2018	CYP2R1 is the major 25-hydroxylase enzyme that is responsible for the 1st activation step of vitamin D.	Vitamin D	93-102	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
29804528-6	2018	OBJECTIVE: to investigate the contribution of polymorphisms in CYP2R1 gene to vitamin D deficiency and incidence of MI in Egyptians.	Vitamin D	78-87	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	63-69
29138801-2	2018	Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor.	Vitamin D	48-57	vitamin D receptor	Rattus norvegicus	109-127
28433688-0	2018	Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells.	Vitamin D	0-9	interleukin 23 receptor	Homo sapiens	28-42
29504336-0	2018	Vitamin D Deficiency In Pakistan: Tip Of Iceberg.	Vitamin D	0-9	TOR signaling pathway regulator	Homo sapiens	34-37
29504336-11	2018	CONCLUSIONS: Vitamin D deficiency is affecting the Pakistani population irrespective of age and gender, and the results of this study have demonstrated that vitamin D deficiency in Pakistan is the tip of iceberg..	Vitamin D	157-166	TOR signaling pathway regulator	Homo sapiens	197-200
29653812-6	2018	Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P &lt; .05 for all).	Vitamin D	0-9	apolipoprotein C3	Homo sapiens	269-276
29169581-11	2018	At baseline, those with vitamin D&gt;25nmol/L performed better on verbal fluency (beta=2.46, 95%CI=0.53,4.40) and TMT-B time (beta=-18.23, 95%CI=-32.86,-3.61), with higher executive function (beta=1.40, 95%CI=0.44,2.37).	Vitamin D	24-33	tubulin beta 4B class IVb	Homo sapiens	82-88
29208234-8	2017	In other cell types S1PR2 is regulated by vitamin D; here we found that treatment with 1,25(OH)2D3 for 48 or 72 h reduces S1PR2 (4-fold; &lt;0.05), but not R1 and R3, expression.	Vitamin D	42-51	sphingosine-1-phosphate receptor 2	Homo sapiens	20-25
29208234-11	2017	Importantly, expression of S1PR2, and therefore S1P function, can be down-regulated by vitamin D.	Vitamin D	87-96	sphingosine-1-phosphate receptor 2	Homo sapiens	27-32
29186865-4	2017	The organic anion transporter 1 (OAT-1) overexpressing ciPTEC line presented 1alpha-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR), responsible for vitamin D activation, degradation and function, respectively.	Vitamin D	136-145	solute carrier family 22 member 6	Homo sapiens	4-31
29186865-4	2017	The organic anion transporter 1 (OAT-1) overexpressing ciPTEC line presented 1alpha-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR), responsible for vitamin D activation, degradation and function, respectively.	Vitamin D	136-145	solute carrier family 22 member 6	Homo sapiens	33-38
29038561-8	2017	DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele.	Vitamin D	92-101	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	7-13
29042790-9	2017	The serum vitamin D level in the "positive for CAD" group was 20.98 ng/mL, significantly lower than the level in the "negative for CAD" group (30.47 ng/mL; P&lt;0.001).	Vitamin D	10-19	aconitate decarboxylase 1	Homo sapiens	47-51
28674792-7	2017	Adipose tissue MCP-1 concentration also reduced in HFD + vitamin D group compared with HFD group.	Vitamin D	57-66	C-C motif chemokine ligand 2	Rattus norvegicus	15-20
28922414-2	2017	Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers.	Vitamin D	0-9	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	153-157
28922414-4	2017	We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE.	Vitamin D	21-30	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	107-111
28470739-9	2017	There was a trend towards decreased mucosal-associated invariant T cells (MAIT) cell frequency in patients receiving vitamin D and free serum 25-hydroxyvitamin D (free-s25OHD) correlated positively with CD38 expression by these cells.	Vitamin D	117-126	CD38 molecule	Homo sapiens	203-207
28229278-0	2017	Consumption of vitamin D-fortified yogurt drink increased leptin and ghrelin levels but reduced leptin to ghrelin ratio in type 2 diabetes patients: a single blind randomized controlled trial.	Vitamin D	15-24	leptin	Homo sapiens	58-64
28229278-0	2017	Consumption of vitamin D-fortified yogurt drink increased leptin and ghrelin levels but reduced leptin to ghrelin ratio in type 2 diabetes patients: a single blind randomized controlled trial.	Vitamin D	15-24	leptin	Homo sapiens	96-102
31902860-12	2019	The present study demonstrated a positive association between serum vitamin D status and skeletal muscle mass and grip strength in patients on peritoneal dialysis.	Vitamin D	68-77	glutamate receptor interacting protein 1	Homo sapiens	114-118
28229278-1	2017	PURPOSE: This study aimed to evaluate the effect of daily consumption of vitamin D-fortified yogurt drink (doogh) in comparison with plain doogh on appetite-regulating hormones including leptin and ghrelin in type 2 diabetes (T2D) patients.	Vitamin D	73-82	leptin	Homo sapiens	187-193
28872092-1	2017	The biological effects mediated by vitamin D and vitamin D receptor (VDR) are involved in the regulation of multiple pathophysiologic processes, including calcium phosphorus metabolism, immune regulation, anti-inflammation, anti-infection and cancer prevention, etc.	Vitamin D	35-44	vitamin D receptor	Felis catus	69-72
30557404-3	2018	In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0.28); p21 expression alone and relative to mib-1 expression increased 29% (P = 0.06) and 73% (P = 0.06), respectively; and bax expression relative to mib-1 expression increased 58% (P = 0.21).	Vitamin D	7-16	H3 histone pseudogene 16	Homo sapiens	157-160
28798354-5	2017	Enpp1 ttw/ttw mice also exhibited significantly reduced renal Klotho expression under phosphate overload conditions, and aging phenotypes in these mice were rescued by Klotho overexpression, a low vitamin D diet or vitamin D receptor knockout.	Vitamin D	197-206	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	0-5
30557404-6	2018	These pilot study results support further investigation of whether 1) vitamin D and calcium promote colorectal epithelial cell differentiation, reduce proliferation, and promote apoptosis in the normal-appearing human colorectal mucosa, 2) vitamin D and calcium act as chemopreventive agents against colorectal neoplasms, and 3) mib-1, p21, and bax are potential "treatable", pre-neoplastic, biomarkers of risk for colorectal neoplasms.	Vitamin D	240-249	H3 histone pseudogene 16	Homo sapiens	336-339
30248338-4	2018	The mRNA levels of hepatic VDR- and vitamin D-related genes [cytochrome P450 (CYP) 2R1, CYP27A1, and CYP3A4] were higher in NAFL patients compared with normal liver subjects.	Vitamin D	36-45	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	61-86
27402475-1	2017	BACKGROUND &amp; AIMS: In vitro studies suggest that vitamin D may reduce hepcidin expression and pro-inflammatory cytokine release from monocytes.	Vitamin D	53-62	hepcidin antimicrobial peptide	Homo sapiens	74-82
28853522-0	2017	[THE EFFECT OF VITAMIN D ON THE EXPRESSION OF ADAMTS13 IN CULTURED ENDOTHELIAL CELLS EXPOSED TO A DIABETIC-LIKE ENVIRONMENT].	Vitamin D	15-24	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	46-54
28853522-7	2017	This study evaluated the role of vitamin D on ADAMTS13 activity in human umbilical vein endothelial cells (HUVEC) exposed to a diabetic-like environment.	Vitamin D	33-42	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	46-54
28853522-13	2017	Normalization of ADAMTS13 by vitamin D may contribute to improvement in hypercoagulability.	Vitamin D	29-38	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	17-25
30248338-4	2018	The mRNA levels of hepatic VDR- and vitamin D-related genes [cytochrome P450 (CYP) 2R1, CYP27A1, and CYP3A4] were higher in NAFL patients compared with normal liver subjects.	Vitamin D	36-45	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	88-95
30405883-3	2018	In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D.	Vitamin D	54-63	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	94-100
28575224-12	2017	Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity.	Vitamin D	102-111	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	269-275
30405883-3	2018	In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D.	Vitamin D	156-165	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	94-100
28509078-10	2017	Compared to baseline, vascular cell adhesion molecule-1 and E-selectin levels decreased significantly in vitamin D treated subjects; however, there were no significant differences between two groups.	Vitamin D	105-114	selectin E	Homo sapiens	60-70
30287811-0	2018	Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study.	Vitamin D	53-62	insulin like growth factor binding protein 3	Homo sapiens	40-47
27671249-0	2017	Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats.	Vitamin D	29-38	CD44 molecule (Indian blood group)	Rattus norvegicus	146-150
30287811-7	2018	As surrogate markers to these processes, the insulin-like growth factor binding protein -2  (IGFBP-2) was upregulated in males, whereas   IGFBP-3 was upregulated in females from the high Vitamin D status.	Vitamin D	187-196	insulin like growth factor binding protein 3	Homo sapiens	138-145
27987058-7	2017	Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2).	Vitamin D	64-73	interleukin 4	Mus musculus	157-161
30287811-9	2018	CONCLUSIONS: The high Vitamin D status correlated with the serological upregulation of IGFBP-2 in males and IGFBP-3 in females with obesity and may constitute surrogate markers of risk reduction of cardiometabolic disease.	Vitamin D	22-31	insulin like growth factor binding protein 3	Homo sapiens	108-115
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	65-71
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	75-82
28913556-7	2018	Vitamin D decreased the number of CD103+ DCs among LPMCs (p = 0.006).	Vitamin D	0-9	integrin subunit alpha E	Homo sapiens	34-39
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	262-269
28913556-8	2018	Furthermore, vitamin D induced mRNA expression of TGF-beta (p = 0.048), TNF-alpha (p = 0.006) and PD-L1 (p = 0.02) and tended to induce IL-10 expression (p = 0.06).	Vitamin D	13-22	CD274 molecule	Homo sapiens	98-103
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	CD274 molecule	Homo sapiens	141-146
28186657-0	2017	Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium, and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease.	Vitamin D	15-24	fibroblast growth factor 23	Canis lupus familiaris	63-90
28186657-8	2017	All vitamin D metabolites were negatively correlated with PTH, FGF-23, and phosphorus concentrations (r: -0.39 to -0.64; P &lt; .01).	Vitamin D	4-13	fibroblast growth factor 23	Canis lupus familiaris	63-69
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	nuclear factor of activated T cells 2	Homo sapiens	184-190
28913556-10	2018	CONCLUSION: High-dose vitamin D supplementation is well tolerated by healthy subjects and has a direct effect on the CD103+ DCs, local cytokine and surface marker mRNA expression in the colonic mucosa, suggestive of a shift towards a more tolerogenic milieu.	Vitamin D	22-31	integrin subunit alpha E	Homo sapiens	117-122
28422993-9	2017	Anti-inflammatory vitamin D interfered with the IL-1beta release and suppressed caspase-5 in keratinocytes and in psoriatic skin lesions.	Vitamin D	18-27	caspase 5	Homo sapiens	80-89
30271082-0	2018	Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/beta-catenin signalling pathway.	Vitamin D	29-38	catenin beta 1	Rattus norvegicus	99-111
30539132-1	2018	Vitamin D concentrations corresponding to 75 nmol/L 25(OH)D have been associated with maintained muscle function, growth and regeneration, optimal bone health and immunology in athletes.	Vitamin D	0-9	immunoglobulin kappa variable 3D-7	Homo sapiens	50-59
28415985-5	2017	Patients were genotyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020, rs2282679), CYP2R1 (rs2060793, rs12794714), CYP27B1 (rs10877012), and DHCR7 (rs12785878).	Vitamin D	51-60	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	130-136
28120456-7	2017	Because vitamin D-induced hypercalcaemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcaemia on renal sodium and water handling.	Vitamin D	8-17	endothelin 1	Mus musculus	75-92
29864718-5	2018	On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.	Vitamin D	19-28	CD274 molecule	Homo sapiens	42-47
28412753-9	2017	RESULTS: PD-1 expression upon T cell stimulation was increased in CD4+CD25+int T cells in vitamin D treated CD patients from 19% (range 10 - 39%) to 29% (11 - 79%)(p = 0.03) compared with placebo-treated patients.	Vitamin D	90-99	interleukin 2 receptor subunit alpha	Sus scrofa	70-74
28376103-0	2017	Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: A randomised double-blinded, placebo-control trial.	Vitamin D	14-23	dipeptidyl peptidase 4	Homo sapiens	72-78
28376103-7	2017	We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV.	Vitamin D	35-44	dipeptidyl peptidase 4	Homo sapiens	184-190
29684480-0	2018	Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D.	Vitamin D	15-24	fetuin B	Homo sapiens	0-8
28376103-13	2017	Our important finding revealed that upon correction of vitamin D insufficiency or deficiency, the serum IP-10 and DPP IV levels were decreased significantly as compare to the placebo group (delta changes; 83.27 vs -133.80; 95% CI [-326.910, -40.758], p = 0.0125, and 271.04 vs -518.69; 95% CI [-1179,15, -59.781], p = 0.0305, respectively.	Vitamin D	55-64	dipeptidyl peptidase 4	Homo sapiens	114-120
29684480-0	2018	Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D.	Vitamin D	89-98	fetuin B	Homo sapiens	0-8
28232093-0	2017	Epigenomic PU.1-VDR crosstalk modulates vitamin D signaling.	Vitamin D	40-49	Spi-1 proto-oncogene	Homo sapiens	11-15
28944524-6	2018	However, after 24 weeks irrespective of initial randomization, vitamin D increased in patients with severe obstructive sleep apnea (9.56 +- 5.51 ng mL-1 , P = 0.045) and in sleepy patients (14.0 +- 4.69 ng mL-1 , P = 0.007).	Vitamin D	63-72	L1 cell adhesion molecule	Mus musculus	148-152
28338939-0	2017	It Remains Unknown Whether Filaggrin Gene Mutations Evolved to Increase Cutaneous Synthesis of Vitamin D.	Vitamin D	95-104	filaggrin	Homo sapiens	27-36
28338939-3	2017	Importantly, FLG mutation carriers have 10% increased serum vitamin D concentrations compared to controls.	Vitamin D	60-69	filaggrin	Homo sapiens	13-16
28944524-6	2018	However, after 24 weeks irrespective of initial randomization, vitamin D increased in patients with severe obstructive sleep apnea (9.56 +- 5.51 ng mL-1 , P = 0.045) and in sleepy patients (14.0 +- 4.69 ng mL-1 , P = 0.007).	Vitamin D	63-72	L1 cell adhesion molecule	Mus musculus	206-210
29212401-8	2018	In conclusions with administration and increasing the amount of vitamin D serum levels, the serum levels of AMH have increased.	Vitamin D	64-73	anti-Mullerian hormone	Homo sapiens	108-111
27821544-0	2017	Phosphate and Vitamin D Prevent Periodontitis in X-Linked Hypophosphatemia.	Vitamin D	14-23	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	49-74
29742726-9	2018	Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes.	Vitamin D	104-113	insulin like growth factor 2	Homo sapiens	35-41
29742726-9	2018	Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes.	Vitamin D	104-113	insulin like growth factor binding protein 3	Homo sapiens	62-69
28904495-0	2017	To Study the Vitamin D Levels in Infertile Females and Correlation of Vitamin D Deficiency with AMH Levels in Comparison to Fertile Females.	Vitamin D	70-79	anti-Mullerian hormone	Homo sapiens	96-99
29742726-12	2018	This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction.	Vitamin D	83-92	insulin like growth factor binding protein 3	Homo sapiens	58-65
28904495-2	2017	Vitamin D regulates antimullerian hormone (AMH), FSH, mRNA, and expression of genes in reproductive tissues, implicating a role in female reproduction.	Vitamin D	0-9	anti-Mullerian hormone	Homo sapiens	43-46
28904495-3	2017	AIMS: To study the vitamin D levels in infertile females and to know the correlation of vitamin D deficiency (VDD) with serum AMH in infertile females compare to fertile females.	Vitamin D	88-97	anti-Mullerian hormone	Homo sapiens	126-129
29742726-12	2018	This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction.	Vitamin D	173-182	insulin like growth factor binding protein 3	Homo sapiens	58-65
28904495-9	2017	STATISTICAL ANALYSIS USED: To analyze the correlation between vitamin D and AMH linear regression test and for comparison of both the groups, two sample t tests were used.	Vitamin D	62-71	anti-Mullerian hormone	Homo sapiens	76-79
28904495-11	2017	In vitamin D deficient cases, the mean for vitamin D was 6.18 +- 2.09 and AMH was 1.94 +- 1.30.	Vitamin D	3-12	anti-Mullerian hormone	Homo sapiens	74-77
29742726-13	2018	Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population.	Vitamin D	113-122	insulin like growth factor binding protein 3	Homo sapiens	46-53
28904495-12	2017	In vitamin D deficient controls, the mean for vitamin D was 4.85 +- 3.02 and AMH was 3.47 +- 2.59.	Vitamin D	3-12	anti-Mullerian hormone	Homo sapiens	77-80
28353634-7	2017	In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1alpha, PGC1alpha, PPARalpha, VLCAD, LCAD, MCAD, and UCP1.	Vitamin D	13-22	carnitine palmitoyltransferase 1A	Rattus norvegicus	113-122
28353634-7	2017	In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1alpha, PGC1alpha, PPARalpha, VLCAD, LCAD, MCAD, and UCP1.	Vitamin D	13-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	135-144
28008453-0	2018	Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.	Vitamin D	55-64	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	24-30
28300755-6	2017	Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells.	Vitamin D	0-9	matrix metallopeptidase 1	Homo sapiens	66-70
28300755-6	2017	Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells.	Vitamin D	0-9	kallikrein related peptidase 7	Homo sapiens	114-118
28008453-10	2018	CONCLUSIONS: The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination (GC1F/1F), and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS.	Vitamin D	157-166	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	133-139
29290431-3	2018	In the intracrine vitamin D pathway, pathogen recognition receptors upregulate CYP27B1 mRNA that encodes for the enzyme that converts 25-hydroxyvitamin D [25(OH)D3] to the active vitamin D hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	18-27	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Bos taurus	79-86
28296915-0	2017	Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study.	Vitamin D	25-34	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	43-49
28296915-11	2017	This study provides evidence that not only vitamin D level but also genetic variation of CYP2R1 in the vitamin D cascade influences host immune response in chronic HBV infection.	Vitamin D	103-112	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	89-95
29290431-3	2018	In the intracrine vitamin D pathway, pathogen recognition receptors upregulate CYP27B1 mRNA that encodes for the enzyme that converts 25-hydroxyvitamin D [25(OH)D3] to the active vitamin D hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	144-153	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Bos taurus	79-86
28029003-0	2017	Effect of Vitamin D Status on Von Willebrand Factor and ADAMTS13 in Diabetic Patients on Chronic Hemodialysis.	Vitamin D	10-19	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	56-64
29178579-2	2018	VDR is a ligand transcription factor and mediates the actions of calcitriol, the active product of vitamin D synthesis.	Vitamin D	99-108	vitamin D receptor	Canis lupus familiaris	0-3
28382877-4	2017	In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped.	Vitamin D	27-36	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	84-90
29243851-8	2018	In conclusion, vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.	Vitamin D	15-24	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	90-94
29116467-2	2018	1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, is known to inhibit expression of CYP27B1, which is very similar in structure and function to CYP27A1, the synthesizing enzyme of 27HC.	Vitamin D	14-23	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	168-175
28222027-0	2017	Vitamin D modulates the expression of HLA-DR and CD38 after in vitro activation of T-cells.	Vitamin D	0-9	CD38 molecule	Homo sapiens	49-53
29116467-7	2018	CONCLUSIONS: Vitamin D supplementation can decrease circulating 27HC of breast cancer patients, likely by CYP27A1 inhibition.	Vitamin D	13-22	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	106-113
31038028-11	2018	Current evidence suggests that vitamin D supplementation in conjunction with standard of care (e.g. chemotherapy, radiation therapy) may confer clinical benefits such as a decrease in serum PSA levels and VDR expression but further research is required to ascertain these results.	Vitamin D	31-40	kallikrein related peptidase 3	Homo sapiens	190-193
27977320-1	2017	Context: The vitamin D receptor (VDR) and enzymes involved in activation (CYP2R1, CYP27B1) and inactivation (CYP24A1) of vitamin D are expressed in ovary, testes, and spermatozoa.	Vitamin D	13-22	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	74-80
28063949-0	2017	Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice.	Vitamin D	0-9	sirtuin 1	Mus musculus	67-72
28028727-10	2017	Low 25-(OH)-vitamin D levels were associated with female sex (OR 1.74, 95% CI 1.59-2.42), current smoking (OR 2.21, 95% CI 1.47-3.39), education (OR 1.1, 95% CI 1.06-1.13), physical activity (OR 1.74, 95% CI 1.31-2.23), and high levels of glycated hemoglobin (OR 1.16, 95% CI 1.07-1.25).	Vitamin D	12-21	olfactory receptor family 4 subfamily F member 16	Homo sapiens	146-152
28063949-8	2017	This study demonstrates a novel molecular mechanism by which vitamin-D can prevent oxidative stress and upregulates glucose uptake via SIRT1/AMPK/IRS1/GLUT4 cascade in HG-treated adipocytes and in adipose tissue of HFD diabetic mice.	Vitamin D	61-70	sirtuin 1	Mus musculus	135-140
28063949-8	2017	This study demonstrates a novel molecular mechanism by which vitamin-D can prevent oxidative stress and upregulates glucose uptake via SIRT1/AMPK/IRS1/GLUT4 cascade in HG-treated adipocytes and in adipose tissue of HFD diabetic mice.	Vitamin D	61-70	insulin receptor substrate 1	Mus musculus	146-150
28374624-7	2017	Furthermore, high serum leptin was negatively associated with vitamin D and physical performance.	Vitamin D	62-71	leptin	Homo sapiens	24-30
27537342-1	2017	The present study investigated the associations between serum vitamin D levels and carotid intima-media thickness (CIMT), carotid plaque and atherosclerosis in 71 Korean adults.	Vitamin D	62-71	CIMT	Homo sapiens	115-119
27254743-0	2017	Effects of supplemental calcium and vitamin D on the APC/beta-catenin pathway in the normal colorectal mucosa of colorectal adenoma patients.	Vitamin D	36-45	catenin beta 1	Homo sapiens	57-69
28374624-8	2017	CONCLUSIONS: Serum leptin levels were correlated with low vitamin D, reduced muscle strength and functional impairment, suggesting that serum leptin might serve as a biomarker reflecting physical performance in OA patients.	Vitamin D	58-67	leptin	Homo sapiens	19-25
27254743-5	2017	These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, beta-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	31-40	catenin beta 1	Homo sapiens	96-108
27254743-5	2017	These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, beta-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	31-40	catenin beta 1	Homo sapiens	328-340
29160418-13	2017	These data demonstrated an association between serum vitamin D levels and outcomes of obese asthma, and indicated that NLRP3 inflammasome may play a role in this disorder.	Vitamin D	53-62	NLR family, pyrin domain containing 3	Mus musculus	119-124
28122601-12	2017	CONCLUSIONS: The loss of muscle mass in slow muscles in the absence of vitamin D signaling is due to elevated levels of phosphorylated Stat3 that leads to an increase in Myostatin signaling, which in turn decreases protein synthesis and fiber size through the phosphorylation of p70S6K and rpS6, respectively.	Vitamin D	71-80	myostatin	Mus musculus	170-179
29088291-2	2017	Vitamin D is activated by 25-hydroxylase (CYP2R1) and 1-alpha-hydroxylase (CYP27B1) and is degraded by 24-hydroxylase (CYP24A1).	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Sus scrofa	42-48
27773703-13	2017	The purified LCA-positive glycoform megalin had higher binding activity for RBP and vitamin D-binding protein than did WGA-positive glycoform megalin.	Vitamin D	84-93	low density lipoprotein receptor-related protein 2	Mus musculus	36-43
29088291-5	2017	Vitamin D-metabolizing enzymes CYP2R1, CYP27B1, and CYP24A1, vitamin D binding protein GC, and vitamin D receptor VDR were expressed in the endometrium in a pregnancy stage-specific manner as well as in conceptus and chorioallantoic tissues during pregnancy.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Sus scrofa	31-37
28903788-1	2017	Vitamin D could modulate pathways leading to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).	Vitamin D	0-9	peripheral myelin protein 22	Homo sapiens	93-100
28123720-13	2017	However, in vitamin D-treated mice, the thymus indexes, the ratios of CD4+/CD8+, secretion of IL-2 and the proliferation index of spleen T lymphocytes were significantly increased (P&lt;0.05).	Vitamin D	12-21	interleukin 2	Mus musculus	94-98
28123720-15	2017	These results indicate that vitamin D supplementation can improve immune recovery in immunosuppressant mice by stimulating T-cell proliferation and elevating IL-2 production.	Vitamin D	28-37	interleukin 2	Mus musculus	158-162
27060335-3	2017	Mutations in CYP27B1 cause 1alpha-hydroxylase deficiency, also known as vitamin D dependent rickets type I or hereditary pseudo-vitamin D deficient rickets; very rare mutations in CYP2R1 can cause 25-hydroxylase deficiency.	Vitamin D	72-81	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	180-186
28961553-0	2017	Vitamin D increases IGF-I and insulin levels in experimental diabetic rats.	Vitamin D	0-9	insulin-like growth factor 1	Rattus norvegicus	20-25
27060335-3	2017	Mutations in CYP27B1 cause 1alpha-hydroxylase deficiency, also known as vitamin D dependent rickets type I or hereditary pseudo-vitamin D deficient rickets; very rare mutations in CYP2R1 can cause 25-hydroxylase deficiency.	Vitamin D	128-137	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	180-186
28961553-2	2017	The aim of this study is to examine the effect of vitamin D intake on the serum levels of glucose, insulin, and IGF-I in experimental diabetic rats.	Vitamin D	50-59	insulin-like growth factor 1	Rattus norvegicus	112-117
27813049-1	2016	The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues.	Vitamin D	63-72	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	111-117
28961553-8	2017	In addition, a significant decline was observed in the serum IGF-I level of STZ-treated rats in comparison to the controls, which was compensated in the vitamin D group.	Vitamin D	153-162	insulin-like growth factor 1	Rattus norvegicus	61-66
27813049-8	2016	Carriers of the G-allele of the rs2060793 SNP in the CYP2R1 gene, a genotype previously associated with rickets, had lower levels of CYP2R1 mRNA.In conclusion, this study suggest that the kidneys rather than the liver, may be of importance for fetal vitamin D metabolism, even for the 25-hydroxylation, during the first trimester.	Vitamin D	250-259	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	53-59
27813049-8	2016	Carriers of the G-allele of the rs2060793 SNP in the CYP2R1 gene, a genotype previously associated with rickets, had lower levels of CYP2R1 mRNA.In conclusion, this study suggest that the kidneys rather than the liver, may be of importance for fetal vitamin D metabolism, even for the 25-hydroxylation, during the first trimester.	Vitamin D	250-259	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	133-139
28961553-9	2017	The serum vitamin D concentration was positively correlated to the changes in IGF-I level by Pearson test.	Vitamin D	10-19	insulin-like growth factor 1	Rattus norvegicus	78-83
28961553-10	2017	CONCLUSIONS: These data showed for the first time that vitamin D intake could significantly improve fasting plasma glucose, insulin, and IGF-I in an experimental type 1 diabetes model.	Vitamin D	55-64	insulin-like growth factor 1	Rattus norvegicus	137-142
27473561-0	2017	CYP2R1 mutations causing vitamin D-deficiency rickets.	Vitamin D	25-34	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
27569350-6	2016	A self-organizing map approach subdivided the vitamin D-sensitive CTCF sites into seven classes that can be distinguished by participation in DNA loop formation, binding to open chromatin, carrying binding motifs for CTCF or its relative BORIS, overlap with transcription start site (TSS) regions and binding of VDR.	Vitamin D	46-55	CCCTC-binding factor like	Homo sapiens	238-243
27473561-1	2017	CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D].	Vitamin D	91-100	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
26319202-2	2016	However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems.	Vitamin D	19-28	multidrug resistance protein 1	Ovis aries	83-97
27473561-7	2017	We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D.	Vitamin D	89-98	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	54-60
27473561-7	2017	We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D.	Vitamin D	162-171	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	54-60
26429395-2	2016	Since adipocytes express VDR and obesity is a known risk factor for cancer, vitamin D actions in adipose tissue may contribute to its cancer protective effects.	Vitamin D	76-85	WD and tetratricopeptide repeats 1	Mus musculus	97-104
27473561-11	2017	In silico analyses predicted impaired CYP2R1 folding or reduced interaction with substrate vitamin D by L99P and K242N mutations, respectively.	Vitamin D	91-100	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	38-44
27473561-16	2017	We conclude that mutations in CYP2R1 are responsible for an atypical form of vitamin D-deficiency rickets, which has been classified as vitamin D dependent rickets type 1B (VDDR1B, MIM 600081).	Vitamin D	77-86	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	30-36
27716192-0	2016	Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.	Vitamin D	26-35	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	76-82
27716192-0	2016	Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.	Vitamin D	26-35	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	178-184
27473561-16	2017	We conclude that mutations in CYP2R1 are responsible for an atypical form of vitamin D-deficiency rickets, which has been classified as vitamin D dependent rickets type 1B (VDDR1B, MIM 600081).	Vitamin D	136-145	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	30-36
27716192-13	2016	CONCLUSIONS: Screening of four Vitamin D pathway genes in 39 VKH patients shows that a potentially pathogenic sequence variant in CYP2R1 may cause VKH in a subset of patients.	Vitamin D	31-40	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	130-136
27576086-4	2017	The affinities of the synthesized vitamin D analogs to the full-length recombinant rat VDR were examined, as well as their differentiating and transcriptional activities.	Vitamin D	34-43	vitamin D receptor	Rattus norvegicus	87-90
27379733-9	2016	CONCLUSIONS: DPP4-Is treatment is associated with improved vitamin D balance in people with type 2 diabetes; our findings suggest that vitamin D may underlie the link between DPP4-Is and bone metabolism.	Vitamin D	59-68	dipeptidyl peptidase 4	Homo sapiens	13-17
27379733-9	2016	CONCLUSIONS: DPP4-Is treatment is associated with improved vitamin D balance in people with type 2 diabetes; our findings suggest that vitamin D may underlie the link between DPP4-Is and bone metabolism.	Vitamin D	135-144	dipeptidyl peptidase 4	Homo sapiens	175-179
28159673-0	2017	RIPK1 binds to vitamin D receptor and decreases vitamin D-induced growth suppression.	Vitamin D	15-24	receptor interacting serine/threonine kinase 1	Homo sapiens	0-5
28698476-2	2017	Vitamin D (Vit D) regulates AMH production in vitro, but its role as a regulator of ovarian AMH production is contentious.	Vitamin D	0-9	anti-Mullerian hormone	Homo sapiens	28-31
26997468-2	2016	A few in vitro studies showed that the bioactive form of vitamin D is able to modulate the expression of the anti-Mullerian hormone (AMH) gene.	Vitamin D	57-66	anti-Mullerian hormone	Homo sapiens	109-131
26997468-2	2016	A few in vitro studies showed that the bioactive form of vitamin D is able to modulate the expression of the anti-Mullerian hormone (AMH) gene.	Vitamin D	57-66	anti-Mullerian hormone	Homo sapiens	133-136
28370465-6	2017	These findings uncover crosstalk between the BMP-Smad1 and RANKL-NF-kappaB pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health.	Vitamin D	146-155	SMAD family member 1	Mus musculus	49-54
27321391-2	2016	We described that Candida albicans (Ca) aggravates experimental autoimmune encephalomyelitis (EAE) that is a model to study MS. We also observed that vaccination with a myelin peptide (MOG) in the presence of vitamin D (VitD) protected mice against EAE.	Vitamin D	209-218	myelin oligodendrocyte glycoprotein	Mus musculus	185-188
28370465-6	2017	These findings uncover crosstalk between the BMP-Smad1 and RANKL-NF-kappaB pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health.	Vitamin D	146-155	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	59-64
28287278-4	2017	The aim of this study was to assess a possible association between the levels of HCY and vitamin D and the carotid intima-media thickness (cIMT), which is a known marker for subclinical atherosclerosis in patients with OSA.	Vitamin D	89-98	CIMT	Homo sapiens	139-143
27435264-9	2016	In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression.	Vitamin D	31-40	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154
28537499-0	2017	Vitamin D improves the content of TGF-beta and IGF-1 in intervertebral disc of diabetic rats.	Vitamin D	0-9	insulin-like growth factor 1	Rattus norvegicus	47-52
27573000-5	2016	Other proteins modulated by vitamin D play important roles in calcium regulation e.g., calbindin 1 (CALB1) and transient receptor potential cation channel 6 (TRPV6).	Vitamin D	28-37	calbindin 1	Homo sapiens	87-98
28537499-13	2017	And Vitamin D prevented the discs by improving the content of TGF-beta and IGF-1.	Vitamin D	4-13	insulin-like growth factor 1	Rattus norvegicus	75-80
27573000-5	2016	Other proteins modulated by vitamin D play important roles in calcium regulation e.g., calbindin 1 (CALB1) and transient receptor potential cation channel 6 (TRPV6).	Vitamin D	28-37	calbindin 1	Homo sapiens	100-105
28545072-10	2017	KLF-10 levels tended to be higher in EPCs exposed to vitamin D, with no differences in angiopoietic markers.	Vitamin D	53-62	Kruppel like factor 10	Homo sapiens	0-6
28475114-6	2017	The transcription of specific adipogenesis orchestrating genes, such as aP2, peroxisome proliferator-activated receptor gamma (PPAR-gamma), and that of adipocyte-specific genes, including lipoprotein lipase (LPL) and acyl-CoA thioesterase 2 (ACOT2), was significantly inhibited in cells that had been treated in the presence of melatonin and vitamin D, alone or in combination.	Vitamin D	342-351	lipoprotein lipase	Homo sapiens	208-211
28251655-6	2017	After vitamin D supplementation, the change in 25(OH)D, 24,25(OH)2 D3 and VMR was associated with the change in calcium absorption, PTH and CTX.	Vitamin D	6-15	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	140-143
28259644-6	2017	RESULTS: In the PreDM group, compared with those in the vitamin D sufficient subgroup, vitamin D insufficient subgroup and vitamin D deficient subgroup had higher concentrations of hs-CRP and leptin (P&lt;0.05).	Vitamin D	87-96	leptin	Homo sapiens	192-198
28259644-6	2017	RESULTS: In the PreDM group, compared with those in the vitamin D sufficient subgroup, vitamin D insufficient subgroup and vitamin D deficient subgroup had higher concentrations of hs-CRP and leptin (P&lt;0.05).	Vitamin D	87-96	leptin	Homo sapiens	192-198
28259644-10	2017	CONCLUSIONS: 25(OH) D3 status in PreDM individuals was inversely correlated with concentrations of hs-CRP and leptin, suggesting their involvement in the inflammation response between vitamin D status and PreDM.	Vitamin D	184-193	leptin	Homo sapiens	110-116
27567005-10	2017	The active vitamin D hormone, 1,25(OH)2 D3 likely increased calcification in aortic smooth muscle cells perhaps by directly modulating expression of Alpl, Rankl, and Opg.	Vitamin D	11-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	155-160
28029182-6	2017	Second, vitamin D-induced aorta vascular calcification rate in Nedd4fl/fl ;SM22alpha-Cre mice was significantly higher than their wild-type littermates.	Vitamin D	8-17	transgelin	Mus musculus	75-84
28029182-7	2017	Nedd4fl/fl ;SM22alpha-Cre mice showed a development of vascular calcification even at very low-level injection of vitamin D, but this was not exhibited in wild-type littermates.	Vitamin D	114-123	transgelin	Mus musculus	12-21
28318372-7	2017	ASM/Ht2 were positively associated with vitamin D levels, but negatively associated with white blood cell counts and HOMA-IR by multiple regression analysis.	Vitamin D	40-49	H19 imprinted maternally expressed transcript	Homo sapiens	0-3
28392579-13	2017	In pre-menopausal women the opposite was the case: although there was no correlation between age and breast density, higher vitamin D levels tended to be associated with lower breast density (p = 0.06 for ACR 2 vs. ACR 4) in this smaller sample (n = 412).	Vitamin D	124-133	acrosin	Homo sapiens	205-208
28392579-13	2017	In pre-menopausal women the opposite was the case: although there was no correlation between age and breast density, higher vitamin D levels tended to be associated with lower breast density (p = 0.06 for ACR 2 vs. ACR 4) in this smaller sample (n = 412).	Vitamin D	124-133	acrosin	Homo sapiens	215-218
28392579-14	2017	When vitamin D-rich food and food supplements were also taken into account, regular intake of vitamin D preparations was associated with lower breast density; this association achieved borderline statistical significance (p = 0.05 for ACR 3 vs. ACR 4).	Vitamin D	94-103	acrosin	Homo sapiens	235-238
28392579-14	2017	When vitamin D-rich food and food supplements were also taken into account, regular intake of vitamin D preparations was associated with lower breast density; this association achieved borderline statistical significance (p = 0.05 for ACR 3 vs. ACR 4).	Vitamin D	94-103	acrosin	Homo sapiens	245-248
28392579-15	2017	When the analysis also took menopausal status into account, the breast density of pre-menopausal women was lower following regular vitamin D intake and this lower breast density of pre-menopausal women was statistically highly significant (p &lt; 0.001 for ACR 1 and ACR 2 vs. ACR 4, respectively).	Vitamin D	131-140	peroxiredoxin 5	Homo sapiens	257-262
28392579-15	2017	When the analysis also took menopausal status into account, the breast density of pre-menopausal women was lower following regular vitamin D intake and this lower breast density of pre-menopausal women was statistically highly significant (p &lt; 0.001 for ACR 1 and ACR 2 vs. ACR 4, respectively).	Vitamin D	131-140	acrosin	Homo sapiens	257-260
28392579-15	2017	When the analysis also took menopausal status into account, the breast density of pre-menopausal women was lower following regular vitamin D intake and this lower breast density of pre-menopausal women was statistically highly significant (p &lt; 0.001 for ACR 1 and ACR 2 vs. ACR 4, respectively).	Vitamin D	131-140	acrosin	Homo sapiens	267-270
28089917-8	2017	Expression of the miR processing ribonuclease, DICER1, positively correlated with vitamin D metabolite levels in the clinical trial specimens.	Vitamin D	82-91	dicer 1, ribonuclease III	Homo sapiens	47-53
28143686-0	2017	Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3.	Vitamin D	0-9	interleukin 10	Rattus norvegicus	86-100
28143686-7	2017	Administration of vitamin D in combination with HFD significantly decreased BW gain, decreased the serum levels of both calcium and CRP, increased the serum level of IL-10, improved the general histological appearance of the spleen, and decreased the expression of both CD86 and caspase-3 in the spleen in comparison with results seen in the HFD-C group.	Vitamin D	18-27	interleukin 10	Rattus norvegicus	166-171
26038244-0	2017	Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status.	Vitamin D	57-66	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	21-27
26038244-5	2017	Of the 4 genes, 2 genes, CYP2R1 (rs10741657) and GC (rs2282679), demonstrated a significant association related to vitamin D status.	Vitamin D	115-124	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	25-31
28817810-0	2017	TGF-beta1 is Involved in Vitamin D-Induced Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Regulating the ERK/JNK Pathway.	Vitamin D	25-34	mitogen-activated protein kinase 8	Rattus norvegicus	140-143
28817810-13	2017	TGF-beta1 might be implicated in the vitamin D-induced alterations of BMSCs through regulating ERK/JNK pathway.	Vitamin D	37-46	mitogen-activated protein kinase 8	Rattus norvegicus	99-102
29074823-4	2017	The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D].	Vitamin D	39-48	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	90-96
29074823-4	2017	The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D].	Vitamin D	167-176	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	90-96
27225617-0	2017	The Effect of Treatment of Vitamin D Deficiency on the Level of P-Selectin and hs-CRP in Patients With Thromboembolism: A Pilot Randomized Clinical Trial.	Vitamin D	27-36	selectin P	Homo sapiens	64-74
28241127-5	2017	We found that vitamin D upregulated pattern recognition receptors, TLR2, and NOD2, and induced the antimicrobial human neutrophil peptides (HNP1-3) and LL-37, resulting in increased killing of pneumococci in a vitamin D receptor-dependent manner.	Vitamin D	14-23	HNP1	Homo sapiens	140-146
28241127-8	2017	Moreover, vitamin D lowered inflammatory cytokine production by infected neutrophils via IL-4 production and the induction of suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3, leading to the suppression of NF-kappaB signaling.	Vitamin D	10-19	cytokine inducible SH2 containing protein	Homo sapiens	126-158
28241127-8	2017	Moreover, vitamin D lowered inflammatory cytokine production by infected neutrophils via IL-4 production and the induction of suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3, leading to the suppression of NF-kappaB signaling.	Vitamin D	10-19	cytokine inducible SH2 containing protein	Homo sapiens	160-164
28241127-8	2017	Moreover, vitamin D lowered inflammatory cytokine production by infected neutrophils via IL-4 production and the induction of suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3, leading to the suppression of NF-kappaB signaling.	Vitamin D	10-19	suppressor of cytokine signaling 1	Homo sapiens	175-181
26745966-7	2016	On multivariable analysis, the association between length of ICU stay and vitamin D deficiency remained significant, even after adjusting for key baseline variables, diagnosis, illness severity (PIM-2), PELOD, and need for fluid boluses, ventilation, inotropes and mortality [adjusted mean difference (95 % CI): 3.5 days (0.50-6.53); p = 0.024].	Vitamin D	74-83	Pim-2 proto-oncogene, serine/threonine kinase	Homo sapiens	195-200
27450565-2	2016	It has been shown that in neonatal rats maternally deprived of vitamin D, dopamine (DA) turnover is decreased with associated reductions in one catabolic enzyme, catechol-o-methyl transferase (COMT).	Vitamin D	63-72	catechol-O-methyltransferase	Rattus norvegicus	162-191
27450565-2	2016	It has been shown that in neonatal rats maternally deprived of vitamin D, dopamine (DA) turnover is decreased with associated reductions in one catabolic enzyme, catechol-o-methyl transferase (COMT).	Vitamin D	63-72	catechol-O-methyltransferase	Rattus norvegicus	193-197
27632366-1	2016	The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species.	Vitamin D	82-91	transient receptor potential cation channel subfamily V member 6	Canis lupus familiaris	148-153
27632366-1	2016	The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species.	Vitamin D	82-91	vitamin D receptor	Canis lupus familiaris	206-209
29634094-10	2016	Animal studies confirmed the impact of vitamin D-enriched diet on the reduction in amyloid deposits, AP peptide levels and inflammatory reactions as well as on the increase in the level of neurotrophic factor within the brains of AP protein precursor (APPP) - transgenic mice.	Vitamin D	39-48	LIM homeobox protein 2	Mus musculus	101-103
26303194-11	2016	Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.	Vitamin D	99-108	proprotein convertase subtilisin/kexin type 1	Homo sapiens	74-77
27790417-12	2016	CONCLUSION: The results showed that intake of calcium and vitamin D and estrogen at determined dose led to an increase in OPG and RANKL cytokines reduction which ultimately led to an increase in bone mineral density.	Vitamin D	58-67	TNF receptor superfamily member 11B	Rattus norvegicus	122-125
26319202-2	2016	However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems.	Vitamin D	19-28	multidrug resistance protein 1	Ovis aries	99-103
27037788-12	2016	Vitamin D insufficiency (25OHD &lt;=20 ng mL(-1) ) was associated with global cognitive impairment (OR 1.56, P = 0.028).	Vitamin D	0-9	L1 cell adhesion molecule	Mus musculus	42-48
27374117-8	2016	Furthermore, vitamin D deficiency caused upregulation of the mRNA expression of tumor necrosis factor-alpha, hypoxia-inducible factor-1alpha and its downstream target lysyl oxidase in mesenteric PVAT.	Vitamin D	13-22	hypoxia inducible factor 1, alpha subunit	Mus musculus	109-140
26319202-2	2016	However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems.	Vitamin D	19-28	multidrug resistance protein 1	Ovis aries	105-109
27570856-8	2016	The CYP2R1 rs10741657 gene showed that AG and GG allele carriers had significant risk of vitamin D deficiency.	Vitamin D	89-98	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	4-10
26319202-2	2016	However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems.	Vitamin D	19-28	multidrug resistance protein 1	Ovis aries	111-116
27570856-11	2016	CONCLUSION: The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency.	Vitamin D	142-151	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	99-105
26592177-4	2016	An increased intake of vitamin D3 in a high fat diet-induced obesity mouse model is associated with a decreased weight of white adipose tissue due to induction of apoptosis and the improved blood markers related to adiposity, diabetes, and vitamin D status (plasma concentrations of glucose, insulin, adiponectin, 25-hydroxyvitamin D, and 1,25(OH)2D3).	Vitamin D	23-32	adiponectin, C1Q and collagen domain containing	Mus musculus	301-312
27437780-6	2016	Relation of vitamin D with serum vaspin and omentin levels was determined in these groups.	Vitamin D	12-21	intelectin 1	Homo sapiens	44-51
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	189-195
27437780-8	2016	Omentin levels correlated significantly and negatively with the vitamin D and vaspin levels, but there was a significant positive correlation between omentin and PTH (r=-0.626, p&lt;0.001; r=-0.867, p&lt;0.001; r=0.461, P&lt;0.001, respectively).	Vitamin D	64-73	intelectin 1	Homo sapiens	0-7
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	205-212
27437780-12	2016	The results of this study suggested that there was a significant, positive correlation between serum vitamin D levels and vaspin, whereas a significant, negative correlation between vitamin D levels and omentin.	Vitamin D	182-191	intelectin 1	Homo sapiens	203-210
27252374-7	2016	Vitamin D supplementation of the Ca and P deficient diet considerably augmented transcription of TLR2b, TLR4, CATH1, and CATHB1 and predominantly Th2 cytokines in spleen.	Vitamin D	0-9	toll like receptor 4	Gallus gallus	104-108
26994969-5	2016	Ha1 expression is lost during catagen in all mice but recovers more slowly in the knockout pups on the vitamin D-deficient, low-calcium diet.	Vitamin D	103-112	keratin 31	Mus musculus	0-3
27252374-7	2016	Vitamin D supplementation of the Ca and P deficient diet considerably augmented transcription of TLR2b, TLR4, CATH1, and CATHB1 and predominantly Th2 cytokines in spleen.	Vitamin D	0-9	cathelicidin-1	Gallus gallus	110-115
27184385-8	2016	Critically, knockdown of SLC20A2 gene and protein with CRISPR technology in SaOs2 cells significantly ablated vitamin D mediated inhibition of calcification.	Vitamin D	110-119	solute carrier family 20 member 2	Homo sapiens	25-32
27252374-7	2016	Vitamin D supplementation of the Ca and P deficient diet considerably augmented transcription of TLR2b, TLR4, CATH1, and CATHB1 and predominantly Th2 cytokines in spleen.	Vitamin D	0-9	cathelicidin B1	Gallus gallus	121-127
27184385-10	2016	It also suggests that vitamin D might be used to regulate SLC20A2 gene expression, as well as reduce brain calcification which occurs in Fahr"s disease and normal aging.	Vitamin D	22-31	solute carrier family 20 member 2	Homo sapiens	58-65
27252374-8	2016	Supplementation of the control diet with vitamin D downregulated TLR4 transcription, and dose-dependently increased CATH1, CATHB1, Th1, and Th2 cytokine transcription (Th2&gt;Th1).	Vitamin D	41-50	toll like receptor 4	Gallus gallus	65-69
27252374-8	2016	Supplementation of the control diet with vitamin D downregulated TLR4 transcription, and dose-dependently increased CATH1, CATHB1, Th1, and Th2 cytokine transcription (Th2&gt;Th1).	Vitamin D	41-50	cathelicidin-1	Gallus gallus	116-121
27252374-8	2016	Supplementation of the control diet with vitamin D downregulated TLR4 transcription, and dose-dependently increased CATH1, CATHB1, Th1, and Th2 cytokine transcription (Th2&gt;Th1).	Vitamin D	41-50	cathelicidin B1	Gallus gallus	123-129
27160686-2	2016	SNPs in CYP2R1, which encodes a vitamin D 25-hydroxylase enzyme, are known to influence vitamin D status, but their potential role in determining susceptibility to TB has not previously been investigated in any setting.	Vitamin D	32-41	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	8-14
27783938-0	2016	Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.	Vitamin D	0-9	X-box binding protein 1	Homo sapiens	109-114
27121020-8	2016	The expression of pulmonary surfactant-associated protein B (SP-B) and peroxiredoxin 5 (PRDX5) were reduced in P7 lungs of vitamin D deficient mice, while the production of collagen type Iota alpha 1 (COL1A1) was higher in lungs of vitamin D deficient mice.	Vitamin D	123-132	surfactant associated protein B	Mus musculus	18-59
27379733-0	2016	Dipeptidyl peptidase-4 inhibitors and bone metabolism: is vitamin D the link?	Vitamin D	58-67	dipeptidyl peptidase 4	Homo sapiens	0-22
27121020-8	2016	The expression of pulmonary surfactant-associated protein B (SP-B) and peroxiredoxin 5 (PRDX5) were reduced in P7 lungs of vitamin D deficient mice, while the production of collagen type Iota alpha 1 (COL1A1) was higher in lungs of vitamin D deficient mice.	Vitamin D	123-132	surfactant associated protein B	Mus musculus	61-65
27121020-8	2016	The expression of pulmonary surfactant-associated protein B (SP-B) and peroxiredoxin 5 (PRDX5) were reduced in P7 lungs of vitamin D deficient mice, while the production of collagen type Iota alpha 1 (COL1A1) was higher in lungs of vitamin D deficient mice.	Vitamin D	232-241	surfactant associated protein B	Mus musculus	18-59
26778336-9	2016	CONCLUSION: We propose that in obese rat adipocytes, 1,25(OH)2 D down-regulates VDR, resulting in vitamin D resistance, characterized by higher Cyp27b1/1alpha-Hydroxylase and adipogenesis.	Vitamin D	98-107	vitamin D receptor	Rattus norvegicus	80-83
27379733-3	2016	Aim of this study investigated the relationship between treatment with DPP4-Is and vitamin D balance in patients with type 2 diabetes.	Vitamin D	83-92	dipeptidyl peptidase 4	Homo sapiens	71-75
27377727-4	2016	This regulatory role of vitamin D is supported by both Klotho and Nrf2.	Vitamin D	24-33	Klotho	Rattus norvegicus	55-61
27377727-5	2016	A decline in the vitamin D/Klotho/Nrf2 regulatory network may enhance the ageing process, and this is well illustrated by the age-related decline in cognition in rats that can be reversed by administering vitamin D.	Vitamin D	17-26	Klotho	Rattus norvegicus	27-33
27003919-0	2016	Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency.	Vitamin D	61-70	serpin family C member 1	Homo sapiens	42-50
27377727-5	2016	A decline in the vitamin D/Klotho/Nrf2 regulatory network may enhance the ageing process, and this is well illustrated by the age-related decline in cognition in rats that can be reversed by administering vitamin D.	Vitamin D	205-214	Klotho	Rattus norvegicus	27-33
30603307-7	2017	Vitamin D deficiency augmented the decreases in Pax7 mRNA levels and the increases in muscle RING-Finger Protein-1 and atrogin-1 mRNA levels induced by diabetes in the gastrocnemius muscle of mice.	Vitamin D	0-9	F-box protein 32	Mus musculus	119-128
27003919-7	2016	The relevance of the vitamin D pathway on the regulation of SERPINC1 was confirmed in a cell model.	Vitamin D	21-30	serpin family C member 1	Homo sapiens	60-68
27424705-3	2016	Very few case reports in the literature support Vitamin D deficiency as a cause of proximal RTA.	Vitamin D	48-57	MAS related GPR family member F	Homo sapiens	92-95
27003919-8	2016	Incubation of HepG2 with paricalcitol, a vitamin D analog, increased dose-dependently the levels of SERPINC1transcripts and antithrombin released to the conditioned medium.	Vitamin D	41-50	serpin family C member 1	Homo sapiens	100-108
27003919-9	2016	This study shows further evidence of the transcriptional regulation of SERPINC1 by vitamin D and first describes the functional and pathological relevance of mutations affecting VDRE of this gene.	Vitamin D	83-92	serpin family C member 1	Homo sapiens	71-79
26700731-0	2016	Vitamin D modulates tissue factor and protease-activated receptor 2 expression in vascular smooth muscle cells.	Vitamin D	0-9	coagulation factor III, tissue factor	Homo sapiens	20-33
27424705-4	2016	We present a case of a young female who presented with proximal RTA and Fanconi syndrome and excellently responded to Vitamin D replacement.	Vitamin D	118-127	MAS related GPR family member F	Homo sapiens	64-67
26700731-2	2016	Because vascular smooth muscle cell (VSMC)-derived tissue factor (TF) is suggested to be critical for arterial thrombosis, we investigated whether the vitamin D molecules calcitriol and paricalcitol could reduce the expression of TF induced by the proinflammatory cytokine TNF-alpha in human aortic VSMCs.	Vitamin D	151-160	coagulation factor III, tissue factor	Homo sapiens	66-68
27314336-7	2016	Furthermore, our study confirms a deregulation of the vitamin D system: among the transcription factors that potentially regulate the deregulated genes, we find TCF3 and SP1 that are both involved in vitamin D3-induced p27Kip1 expression.	Vitamin D	54-63	cyclin dependent kinase inhibitor 1B	Homo sapiens	219-226
26700731-2	2016	Because vascular smooth muscle cell (VSMC)-derived tissue factor (TF) is suggested to be critical for arterial thrombosis, we investigated whether the vitamin D molecules calcitriol and paricalcitol could reduce the expression of TF induced by the proinflammatory cytokine TNF-alpha in human aortic VSMCs.	Vitamin D	151-160	coagulation factor III, tissue factor	Homo sapiens	230-232
27203211-7	2016	Serum 25(OH)D was inversely associated with LPS-stimulated VDR expression and with baseline or vitamin D-induced TREM-1 expression, adjusting for age, self-rated health, and functional status.	Vitamin D	95-104	triggering receptor expressed on myeloid cells 1	Homo sapiens	113-119
26700731-6	2016	Our data suggest that inflammation promotes a prothrombotic state through the up-regulation of TF function in VSMCs and that the beneficial cardiovascular effects of vitamin D may be partially due to decreases in TF expression and its activity in VSMCs.	Vitamin D	166-175	coagulation factor III, tissue factor	Homo sapiens	213-215
27041081-7	2016	Furthermore, both vitamin D forms induced an expansion of CD25hi cells and upregulated their expression of CTLA-4 and Foxp3 regulatory markers.	Vitamin D	18-27	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	107-113
26425827-5	2016	Vitamin D correlated with blood IgM and IgG3, while RBP correlated with IgG4 and IgA.	Vitamin D	0-9	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	40-44
27038530-9	2016	In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95%CI: -4.08, 0.23; p=0.080).	Vitamin D	70-79	leptin	Homo sapiens	38-44
27904547-0	2016	The effect of vitamin D administration on serum leptin and adiponectin levels in end-stage renal disease patients on hemodialysis with vitamin D deficiency: A placebo-controlled double-blind clinical trial.	Vitamin D	14-23	leptin	Homo sapiens	48-54
27904547-4	2016	The goal of this study was to find the effect of vitamin D administration on serum levels of leptin and adiponectin in ESRD patients.	Vitamin D	49-58	leptin	Homo sapiens	93-99
27904547-11	2016	This study showed that vitamin D administration is associated with an increase in adiponectin and a decrease in leptin level in ESRD patients.	Vitamin D	23-32	leptin	Homo sapiens	112-118
27038530-10	2016	However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95%CI: 0.08, 2.02; p=0.033).	Vitamin D	123-132	leptin	Homo sapiens	99-105
26462119-11	2016	The novel findings provide the conceptual support that persistent FOXO1 activation may be responsible for insulin resistance and impaired glucose metabolism in vitamin D signaling-deficient mice, as well as evidence for the utility of vitamin D supplementation for intervention in DM2.	Vitamin D	160-169	forkhead box O1	Mus musculus	66-71
26340892-0	2015	Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice.	Vitamin D	0-9	myostatin	Mus musculus	123-132
26932723-0	2016	Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer"s disease.	Vitamin D	0-9	estrogen receptor 1 (alpha)	Mus musculus	25-29
26340892-9	2015	Vitamin D-deficient mice also showed increases in myostatin and the atrophy marker E3-ubiqutin ligase MuRF1.	Vitamin D	0-9	myostatin	Mus musculus	50-59
26340892-12	2015	Although suggested in earlier in vitro work, this study is the first to report an in vivo association between vitamin D, myostatin, and the regulation of muscle mass.	Vitamin D	110-119	myostatin	Mus musculus	121-130
26446064-1	2016	OBJECTIVE: To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.	Vitamin D	22-31	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	98-104
26255277-7	2015	Furthermore, preliminary investigation of vitamin D"s contribution to beta-defensin expression in vivo revealed that intramammary 1,25D treatment of lactating cows increased BNBD7 expression in mammary macrophages.	Vitamin D	42-51	beta-defensin 7	Bos taurus	174-179
24997582-0	2015	Vitamin D and melatonin protect the cell"s viability and ameliorate the CCl4 induced cytotoxicity in HepG2 and Hep3B hepatoma cell lines.	Vitamin D	0-9	C-C motif chemokine ligand 4	Homo sapiens	72-76
25724814-1	2015	BACKGROUND: A recent study in children demonstrated that the rs9939609 single-nucleotide polymorphism in the fat mass and obesity (FTO) gene influences prospective weight gain, however, only in those who were vitamin D-deficient.	Vitamin D	209-218	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	131-134
24997582-4	2015	This study was planned to evaluate antioxidant and cytoprotective activity of melatonin and Vitamin D in CCl4 induced cytotoxicity in HepG2 and Hep3B hepatoma cell lines.	Vitamin D	92-101	C-C motif chemokine ligand 4	Homo sapiens	105-109
24997582-5	2015	Based on the cytotoxicity assay, melatonin and Vitamin D were evaluated for cytotoprotective potential against CCl4 induced toxicity in HepG2 and Hep3B liver cell lines by monitoring cell viability, LPO and glutathione (GSH) level.	Vitamin D	47-56	C-C motif chemokine ligand 4	Homo sapiens	111-115
24997582-9	2015	As a result, both melatonin and Vitamin D administration during CCl4 exposure protected liver cells from CCl4 induced cell damage.	Vitamin D	32-41	C-C motif chemokine ligand 4	Homo sapiens	64-68
24997582-9	2015	As a result, both melatonin and Vitamin D administration during CCl4 exposure protected liver cells from CCl4 induced cell damage.	Vitamin D	32-41	C-C motif chemokine ligand 4	Homo sapiens	105-109
25724814-12	2015	CONCLUSIONS: Our data suggest that presurgery vitamin D levels influence the size of genotype effects of FTO rs9939609 on RYGB surgery-induced weight loss in obese patients.	Vitamin D	46-55	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	105-108
26314252-0	2015	The expression of RNA helicase DDX5 is transcriptionally upregulated by calcitriol through a vitamin D response element in the proximal promoter in SiHa cervical cells.	Vitamin D	93-102	DEAD-box helicase 5	Homo sapiens	31-35
26202912-15	2015	WIDER IMPLICATIONS OF THE FINDINGS: At present, while in vitro studies suggest vitamin D has the potential to modify AMH production, clinical study findings are conflicting.	Vitamin D	79-88	anti-Mullerian hormone	Homo sapiens	117-120
26314252-3	2015	In silico analysis revealed the presence of two putative vitamin D response elements (VDREs) in the DDX5 promoter region.	Vitamin D	57-66	DEAD-box helicase 5	Homo sapiens	100-104
26202912-16	2015	If vitamin D does influence AMH production, this could have important therapeutic implications.	Vitamin D	3-12	anti-Mullerian hormone	Homo sapiens	28-31
26348637-10	2015	The results strengthen the hypothesis that megalin and cubilin are likely involved in the secretory pathway of vitamin D into tear fluid by the duct cells.	Vitamin D	111-120	low density lipoprotein receptor-related protein 2	Mus musculus	43-50
26623002-4	2015	RESULTS: Patients with normal carotid intima-media thickness (CIMT) had sufficient vitamin D.	Vitamin D	83-92	CIMT	Homo sapiens	62-66
26623002-6	2015	There was a statistically significant difference in the serum level of vitamin D between patients with increased CIMT, and those with normal intima, with a decreased level in the first group.	Vitamin D	71-80	CIMT	Homo sapiens	113-117
26623002-8	2015	There was a statistically significant correlation in left CIMT between the vitamin D sufficiency group and the vitamin D insufficiency group, with higher values in the second group.	Vitamin D	75-84	CIMT	Homo sapiens	58-62
26623002-8	2015	There was a statistically significant correlation in left CIMT between the vitamin D sufficiency group and the vitamin D insufficiency group, with higher values in the second group.	Vitamin D	111-120	CIMT	Homo sapiens	58-62
26623002-10	2015	CONCLUSIONS: Decreased vitamin D levels in patients with diabetes lead to increased CIMT.	Vitamin D	23-32	CIMT	Homo sapiens	84-88
25604607-3	2015	FGF19 regulates bile acid biosynthesis in the bile duct, glucose metabolism and vitamin D and phosphate homeostasis, raises the metabolic rate, reduces body weight, and ameliorates diabetes in mice.	Vitamin D	80-89	fibroblast growth factor 15	Mus musculus	0-5
26664101-11	2015	The applied training resulted in a blood Hjv increase, which was inversely correlated with the vitamin D concentration.	Vitamin D	95-104	hemojuvelin BMP co-receptor	Homo sapiens	41-44
25957423-0	2015	Role of vitamin D in improvement in changes of podocyte P-cadherin/beta-catenin complex induced by diabetic conditions.	Vitamin D	8-17	cadherin 3	Mus musculus	56-66
26545199-9	2015	CONCLUSION: Levels of the antimicrobial peptides HNP1-3 and LCN2 are lower in nasal secretions in asthmatics and are not substantially affected by a short-term treatment with active vitamin D.	Vitamin D	182-191	HNP1	Homo sapiens	49-53
26251265-2	2015	Active vitamin D (1alpha,25-dihydroxyvitamin D3; 1,25(OH)2 D3) up-regulates CD4(+) T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti-inflammatory adenosine.	Vitamin D	7-16	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	132-136
25957423-1	2015	INTRODUCTION: This study aimed to investigate the effect of vitamin D on the pathologic changes of podocyte beta-catenin and P-cadherin and podocyte permeability induced by diabetic conditions.	Vitamin D	60-69	cadherin 3	Mus musculus	125-135
25957423-6	2015	Advanced glycosylation end products also decreased P-cadherin protein amount by 22.9% and 59.1% (P &lt;.01) at 24 hours, respectively, which was improved by vitamin D.	Vitamin D	157-166	cadherin 3	Mus musculus	51-61
25912039-3	2015	The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-gamma, IL-17 and induction of IL-4.	Vitamin D	23-32	interleukin 4	Mus musculus	143-147
26347486-13	2015	Additionally, intramuscular expression of cytochrome P450 27B1, an enzyme related to vitamin D metabolism, was significantly higher at 1 and 3 h after exercise (P &lt; 0.05) compared with the control group.	Vitamin D	85-94	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	42-62
25912039-9	2015	Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-gamma, while inducing IL-4 and IL-10, would be beneficial.	Vitamin D	46-55	interleukin 4	Mus musculus	174-178
25495336-5	2015	RESULTS: Treatment with 30 ng/mL of vitamin D3, corresponding to an optimal plasma concentration of vitamin D, for 24 h had no effect on PDL cell number and morphology but increased PDL cell osteopontin and osteocalcin mRNA expression by about 70 and 40%, respectively, and, moreover, treatment with vitamin D3 for 48 h enhanced PDL cell alkaline phosphatase activity by about two times showing that vitamin D3 exerts pro-osteogenic effects in human PDL cells.	Vitamin D	36-45	secreted phosphoprotein 1	Homo sapiens	191-202
26413189-0	2015	A vitamin D analog inhibits Th2 cytokine- and TGFbeta -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis.	Vitamin D	2-11	heart and neural crest derivatives expressed 2	Mus musculus	28-31
26298324-0	2015	Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease.	Vitamin D	0-9	forkhead box P3	Mus musculus	96-101
26413189-11	2015	In addition to the previously reported immunosuppressive effect, the vitamin D analog OCT might be effective to treat scleroderma, in part through inhibition of Th2 cytokine- and TGFbeta-induced POSTN expression.	Vitamin D	69-78	heart and neural crest derivatives expressed 2	Mus musculus	161-164
25041340-5	2015	It is suggested that there was a concurrent change in a factor that operated to counteract the effect of increased body weight on grip strength, a prime candidate being a decrease in levels of serum vitamin D.	Vitamin D	199-208	glutamate receptor interacting protein 1	Homo sapiens	130-134
26111345-6	2015	We also found a vitamin D response element in Dicer promoter that interacts in vitro to vitamin D and retinoid X receptors.	Vitamin D	16-25	dicer 1, ribonuclease III	Homo sapiens	46-51
26111345-6	2015	We also found a vitamin D response element in Dicer promoter that interacts in vitro to vitamin D and retinoid X receptors.	Vitamin D	88-97	dicer 1, ribonuclease III	Homo sapiens	46-51
26111345-9	2015	In summary, the data indicate that in SiHa cells, calcitriol stimulates the expression of Dicer possibly through the vitamin D response element located in its promoter.	Vitamin D	117-126	dicer 1, ribonuclease III	Homo sapiens	90-95
26037400-0	2015	Vitamin D levels in multiple sclerosis patients: Association with TGF-beta2, TGF-betaRI, and TGF-betaRII expression.	Vitamin D	0-9	transforming growth factor beta receptor 1	Homo sapiens	77-87
25279449-11	2015	CONCLUSIONS: In addition to non-genetic factors, SNPs in the vitamin D pathway seem to have a role in HCV-2/3 therapy outcomes.	Vitamin D	61-70	BMP binding endothelial regulator	Homo sapiens	102-107
26379918-1	2015	BACKGROUND AND OBJECTIVE: Leptin and vitamin D play an important role in obesity development and metabolic effects; however, the association between leptin and vitamin D is not well studied in Saudi subjects.	Vitamin D	160-169	leptin	Homo sapiens	149-155
25687676-4	2015	RESULTS: Negative correlations between vitamin D intake with plasminogen activator inhibitor-1 (PAI-1) (r=-0.69; p=0.01) and vascular cell adhesion molecule (VCAM-1) (r=-0.82; p=0.001) were found in the population analyzed.	Vitamin D	39-48	serpin family E member 1	Homo sapiens	61-94
26379918-7	2015	In males, vitamin D levels were positively associated with leptin (r = 0.196, P&lt;0.05).	Vitamin D	10-19	leptin	Homo sapiens	59-65
26379918-8	2015	CONCLUSION: Vitamin D was positively associated with serum leptin in male Saudi subjects.	Vitamin D	12-21	leptin	Homo sapiens	59-65
26379918-9	2015	Additionally, male subjects were found to be dyslipidemic, which might be a responsible factor for this discordant association between vitamin D and leptin in Saudi population.	Vitamin D	135-144	leptin	Homo sapiens	149-155
25687676-4	2015	RESULTS: Negative correlations between vitamin D intake with plasminogen activator inhibitor-1 (PAI-1) (r=-0.69; p=0.01) and vascular cell adhesion molecule (VCAM-1) (r=-0.82; p=0.001) were found in the population analyzed.	Vitamin D	39-48	serpin family E member 1	Homo sapiens	96-101
25236689-8	2015	Together these data provide the first evidence that vitamin D deficiency affects disease development in twi mice and that vitamin D3 supplementation has the potential to improve the efficacy of KD therapeutics.	Vitamin D	52-61	galactosylceramidase	Mus musculus	104-107
26134669-0	2015	Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.	Vitamin D	0-9	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	74-80
26227001-8	2015	RESULTS: Vitamin D treatment decreased mean corpuscular volume, reticulocyte count, and plasma erythropoietin levels.	Vitamin D	9-18	erythropoietin	Mus musculus	95-109
26109925-6	2015	Test #2 involved a low biological contrast situation comparing the plasma of rats fed a diet either supplemented or not with vitamin D.	Vitamin D	125-134	decapping mRNA 1A	Rattus norvegicus	0-7
25882990-3	2015	OBJECTIVES: To examine the relationship between miR-21 expression and vitamin D in aorta and bone in atherosclerotic disease.	Vitamin D	70-79	microRNA 21	Homo sapiens	48-54
25882990-11	2015	Vitamin D deficient patients had greater expression of miR-21 in aorta compared with non-deficient patients (p = 0.03).	Vitamin D	0-9	microRNA 21	Homo sapiens	55-61
25882990-12	2015	Increasing CRP and vitamin D deficiency were independent predictors of miR-21 expression in aorta.	Vitamin D	19-28	microRNA 21	Homo sapiens	71-77
25882990-14	2015	CONCLUSION: In atherosclerosis, miR-21 is increased in the aorta and associated with vitamin D deficiency.	Vitamin D	85-94	microRNA 21	Homo sapiens	32-38
25882990-15	2015	Vitamin D deficiency may influence aberrant miR-21 expression in vasculature and bone contributing to the concurrent development of atherosclerosis and osteoporosis.	Vitamin D	0-9	microRNA 21	Homo sapiens	44-50
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	4-13	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	162-169
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	4-13	peroxisome proliferator activated receptor alpha	Homo sapiens	286-290
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	162-169
25551576-7	2014	Our data are consistent with involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon and vitamin D.	Vitamin D	146-155	leukocyte immunoglobulin like receptor B4	Homo sapiens	44-48
26290720-7	2014	RESULTS: The active form of vitamin D (1, 25 (OH)2D3) when administered to cultured equine chondrocytes at two different concentrations significantly increased the expression of Sox 9 at both.	Vitamin D	28-37	SRY-box transcription factor 9	Equus caballus	178-183
26290720-9	2014	CONCLUSIONS: The increased expression of Sox 9, in equine articular chondrocytes in vitro, in response to the active form of vitamin D suggests that this compound could be utilized to inhibit the progressive de-differentiation that is normally observed in these cells.	Vitamin D	125-134	SRY-box transcription factor 9	Equus caballus	41-46
25168880-0	2014	Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers.	Vitamin D	15-24	matrix metallopeptidase 1	Homo sapiens	75-79
25093461-3	2014	Moreover, LH modulates the Leydig expression of CYP2R1, the key enzyme involved in vitamin D (Vit D) 25-hydroxylation.	Vitamin D	83-92	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	48-54
25087094-5	2014	When vitamin D was applied at a concentration of 1 x 10(-7) and 1 x 10(-6) mol/L on A549, PC9, SPC-A1, and H1650 cells for 72 h, no inhibition occurred on cell proliferation.	Vitamin D	5-14	proprotein convertase subtilisin/kexin type 9	Homo sapiens	90-93
25280486-2	2014	The active vitamin D metabolite, calcitriol, and astemizole, a promising antineoplastic drug, target EAG1 by inhibiting its expression and blocking ion currents, respectively.	Vitamin D	11-20	potassium voltage-gated channel, subfamily H (eag-related), member 1	Mus musculus	101-105
24184699-4	2014	In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients.	Vitamin D	65-74	C-C motif chemokine ligand 2	Homo sapiens	108-112
24184871-5	2014	Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1).	Vitamin D	41-50	C-C motif chemokine ligand 2	Homo sapiens	147-177
24184871-5	2014	Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1).	Vitamin D	41-50	C-C motif chemokine ligand 2	Homo sapiens	179-184
24239508-11	2014	These genes possess vitamin D response elements (VDRE) adjacent to TCF/beta-catenin response elements and are regulated by both VDR and beta-catenin signaling.	Vitamin D	20-29	catenin beta 1	Homo sapiens	71-83
24239508-11	2014	These genes possess vitamin D response elements (VDRE) adjacent to TCF/beta-catenin response elements and are regulated by both VDR and beta-catenin signaling.	Vitamin D	20-29	catenin beta 1	Homo sapiens	136-148
24190367-9	2014	CONCLUSION: The association between PSA and sUV may only be evident at low solar UV irradiance, and this effect may be independent of serum vitamin D levels.	Vitamin D	140-149	kallikrein related peptidase 3	Homo sapiens	36-39
24974387-0	2014	Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial.	Vitamin D	25-34	kallikrein related peptidase 3	Homo sapiens	39-42
25088927-3	2014	Thioredoxin-interacting protein (TXNIP), also known as vitamin D-upregulated protein or thioredoxin-binding-protein-2, functions as a physiological inhibitor of Trx, and pathological suppression of Trx by TXNIP has been demonstrated in diabetes and cardiovascular diseases.	Vitamin D	55-64	thioredoxin	Homo sapiens	161-164
25088927-3	2014	Thioredoxin-interacting protein (TXNIP), also known as vitamin D-upregulated protein or thioredoxin-binding-protein-2, functions as a physiological inhibitor of Trx, and pathological suppression of Trx by TXNIP has been demonstrated in diabetes and cardiovascular diseases.	Vitamin D	55-64	thioredoxin	Homo sapiens	198-201
25237378-0	2014	Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells.	Vitamin D	0-9	complement factor H related 1	Homo sapiens	98-103
25237378-3	2014	The aim of the current study therefore is to investigate if vitamin D modulates the expression and activation of MMP-2 and MMP-9 in human lung fibroblasts (HFL-1) cells.	Vitamin D	60-69	complement factor H related 1	Homo sapiens	156-161
24924628-5	2014	1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells.	Vitamin D	19-28	myogenic differentiation 1	Mus musculus	110-114
24924628-5	2014	1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells.	Vitamin D	19-28	myogenin	Mus musculus	116-124
24558199-3	2014	Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE.	Vitamin D	31-40	tryptophan hydroxylase 1	Homo sapiens	244-248
24732451-0	2014	Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.	Vitamin D	31-40	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	44-51
25987250-6	2015	After vitamin D overload, arterial SMCs in Runx2(f/f) mice expressed Runx2, underwent osteogenic phenotype change, and developed severe AMC.	Vitamin D	6-15	runt related transcription factor 2	Mus musculus	43-48
25987250-6	2015	After vitamin D overload, arterial SMCs in Runx2(f/f) mice expressed Runx2, underwent osteogenic phenotype change, and developed severe AMC.	Vitamin D	6-15	runt related transcription factor 2	Mus musculus	69-74
25987250-7	2015	In contrast, vitamin D-treated Runx2(DeltaSM) mice had no Runx2 in blood vessels, maintained SMC phenotype, and did not develop AMC.	Vitamin D	13-22	runt related transcription factor 2	Mus musculus	31-36
25942481-0	2015	CYP2R1 Mutations Impair Generation of 25-hydroxyvitamin D and Cause an Atypical Form of Vitamin D Deficiency.	Vitamin D	88-97	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
25942481-3	2015	OBJECTIVE: This study aimed to determine the prevalence of CYP2R1 mutations in Nigerian children with familial rickets and vitamin D deficiency and assess the functional effect on 25-hydroxylase activity.	Vitamin D	123-132	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	59-65
25942481-5	2015	MAIN OUTCOME MEASURES: Function of mutant CYP2R1 genes as assessed in vivo by serum 25-hydroxyvitamin D values after administration of vitamin D and in vitro by analysis of mutant forms of the CYP2R1.	Vitamin D	94-103	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	42-48
25942481-9	2015	CONCLUSION: These studies confirm that CYP2R1 is the principal 25-hydroxylase in humans and demonstrate that CYP2R1 alleles have dosage-dependent effects on vitamin D homeostasis.	Vitamin D	157-166	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	39-45
25942481-9	2015	CONCLUSION: These studies confirm that CYP2R1 is the principal 25-hydroxylase in humans and demonstrate that CYP2R1 alleles have dosage-dependent effects on vitamin D homeostasis.	Vitamin D	157-166	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	109-115
25942481-10	2015	CYP2R1 mutations cause a novel form of genetic vitamin D deficiency with semidominant inheritance.	Vitamin D	47-56	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
26107738-4	2015	Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23.	Vitamin D	21-30	interleukin 23 subunit alpha	Homo sapiens	159-164
26107738-6	2015	Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23.	Vitamin D	98-107	interleukin 23 subunit alpha	Homo sapiens	156-161
24787057-2	2014	Although the mechanism by which a deficit confers risk is unknown, vitamin D is a potent transcriptional modulator and can regulate proline dehydrogenase (PRODH) expression.	Vitamin D	67-76	proline dehydrogenase 1	Homo sapiens	132-153
24787057-2	2014	Although the mechanism by which a deficit confers risk is unknown, vitamin D is a potent transcriptional modulator and can regulate proline dehydrogenase (PRODH) expression.	Vitamin D	67-76	proline dehydrogenase 1	Homo sapiens	155-160
24384092-3	2014	After prolactin stimulation, only full-length Stat5a interacts with the vitamin D and retinoid X receptors, whereas only Delta5 Stat5a interacts with activating protein 1-2 and specificity protein 1.	Vitamin D	72-81	signal transducer and activator of transcription 5A	Homo sapiens	46-52
24381012-8	2014	In both HOD patients and CCl4-treated mice, an altered vitamin D metabolism with decreased CYP27A1, CYP2R1, vitamin D-binding protein GC and increased 7-dehydrocholesterol reductase hepatic gene expression, results in decreased 25-OH vitamin D serum levels.	Vitamin D	55-64	C-C motif chemokine ligand 4	Homo sapiens	25-29
24381012-8	2014	In both HOD patients and CCl4-treated mice, an altered vitamin D metabolism with decreased CYP27A1, CYP2R1, vitamin D-binding protein GC and increased 7-dehydrocholesterol reductase hepatic gene expression, results in decreased 25-OH vitamin D serum levels.	Vitamin D	108-117	C-C motif chemokine ligand 4	Homo sapiens	25-29
25097830-0	2014	The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes.	Vitamin D	12-21	hepcidin antimicrobial peptide	Homo sapiens	45-53
25097830-6	2014	Recently, hepcidin levels were found to be inversely correlated with vitamin D status in CKD.	Vitamin D	69-78	hepcidin antimicrobial peptide	Homo sapiens	10-18
25097830-7	2014	The aim of this study was to investigate the role of vitamin D in the regulation of hepcidin expression in vitro and in vivo.	Vitamin D	53-62	hepcidin antimicrobial peptide	Homo sapiens	84-92
25097830-8	2014	This study reports that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is associated with decreased hepcidin and increased ferroportin expression in lipopolysaccharide (LPS) stimulated THP-1 cells.	Vitamin D	38-47	hepcidin antimicrobial peptide	Homo sapiens	134-142
24414254-1	2014	Vitamin D (vit D) has anti-inflammatory properties and modulates lung growth, but whether vit D can prevent lung injury after exposure to antenatal inflammation is unknown.	Vitamin D	0-9	vitrin	Rattus norvegicus	11-14
24204002-0	2014	Suppression of iron-regulatory hepcidin by vitamin D.	Vitamin D	43-52	hepcidin antimicrobial peptide	Homo sapiens	31-39
25870995-6	2015	The most striking change was in HIV+ HAART+ patients, where increased frequencies of antigen-specific T cells expressing macrophage inflammatory protein (MIP)-1beta - an important anti-HIV blocking chemokine - were observed, with a concomitant increase in plasma MIP-1beta, both of which correlated significantly with vitamin D levels.	Vitamin D	318-327	C-C motif chemokine ligand 4	Homo sapiens	121-164
24204002-8	2014	This response was associated with a 34% decrease in circulating levels of hepcidin within 24 hours of vitamin D supplementation (P&lt;0.05).	Vitamin D	102-111	hepcidin antimicrobial peptide	Homo sapiens	74-82
24204002-9	2014	These data show that vitamin D is a potent regulator of the hepcidin-ferroportin axis in humans and highlight a potential new strategy for the management of anemia in patients with low vitamin D and/or CKD.	Vitamin D	21-30	hepcidin antimicrobial peptide	Homo sapiens	60-68
24587115-0	2014	Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults.	Vitamin D	47-56	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	19-25
24326417-11	2014	Vitamin D deficiency in BN rats correlates with maternal renal CYP24a1 upregulation followed by CYP27b1 upregulation.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	96-103
24447085-13	2014	The GC1s haplotype is associated with higher VDBP levels, resulting in less freely available vitamin D.	Vitamin D	93-102	solute carrier family 25 member 22	Homo sapiens	4-7
24130335-6	2014	Vitamin D status significantly modified FTO effects (P for interaction = 0.02).	Vitamin D	0-9	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	40-43
24130335-8	2014	Our data suggest that FTO rs9939609 affects child weight gain, and genotype effects are more pronounced among children with insufficient vitamin D levels.	Vitamin D	137-146	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	22-25
24466411-3	2014	In the earliest vertebrates (lamprey), vitamin D metabolism and VDR may well have originated from a duplication of a common PRX/VDR ancestor gene as part of a xenobiotic detoxification pathway.	Vitamin D	39-48	periaxin	Homo sapiens	124-127
24730053-3	2014	METHODS: Twenty-three single-nucleotide polymorphisms (SNPs) of five vitamin D-related genes (CYP27A1, CYP2R1, CYP27B1, GC and VDR) were genotyped in 1442 Chinese children with eczema and 1231 non-allergic controls.	Vitamin D	69-78	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	94-101
24730053-3	2014	METHODS: Twenty-three single-nucleotide polymorphisms (SNPs) of five vitamin D-related genes (CYP27A1, CYP2R1, CYP27B1, GC and VDR) were genotyped in 1442 Chinese children with eczema and 1231 non-allergic controls.	Vitamin D	69-78	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	103-109
24730053-11	2014	CONCLUSION: A vitamin D-related SNP rs4674343 on CYP27A1 was found to be protective against atopic eczema.	Vitamin D	14-23	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	49-56
23941558-6	2014	We next demonstrated that vitamin D, 25(OH)D, and 1,25(OH)2D significantly reduced prostaglandin (PG)E2 production by human lung fibroblasts (HFL-1) but had no effect on transforming growth factor beta1, vascular endothelial growth factor, or fibronectin production.	Vitamin D	26-35	complement factor H related 1	Homo sapiens	142-147
24192346-0	2014	Impact of Vitamin D on amyloid precursor protein processing and amyloid-beta peptide degradation in Alzheimer"s disease.	Vitamin D	10-19	amyloid beta (A4) precursor protein	Mus musculus	23-48
24056290-4	2013	Vitamin D also exerts its effect on respiratory diseases through cell signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the Wnt/beta-catenin signaling pathway, prostaglandins, reactive oxygen species, and nitric oxide synthase.	Vitamin D	0-9	catenin beta 1	Homo sapiens	180-192
26090872-2	2015	Our objective was to determine whether vitamin D deficiency in older adults is associated with reduced thickness of the ganglion cell complex (GCC) and of the retinal nerve fibre layer (RNFL), as measured with high-definition optical coherence tomography (HD-OCT).	Vitamin D	39-48	plexin A2	Homo sapiens	259-262
24958015-4	2015	The treatment of C57BL mice with vitamin D significantly preserves postoperative cognitive function, markedly inhibits surgery-induced interleukin (IL)-17, IL-6, transforming growth factor beta (TGF-beta), and retinoic acid-related orphan receptor (RORgammat) production, and obviously induces IL-10 and forkhead box p3 (Foxp3) expression.	Vitamin D	33-42	forkhead box P3	Mus musculus	304-319
24958015-4	2015	The treatment of C57BL mice with vitamin D significantly preserves postoperative cognitive function, markedly inhibits surgery-induced interleukin (IL)-17, IL-6, transforming growth factor beta (TGF-beta), and retinoic acid-related orphan receptor (RORgammat) production, and obviously induces IL-10 and forkhead box p3 (Foxp3) expression.	Vitamin D	33-42	forkhead box P3	Mus musculus	321-326
25447737-9	2015	hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing.	Vitamin D	78-87	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	0-6
25447737-10	2015	In this way hnRNPC may provide an additional mechanism for the fine-tuning of vitamin D-regulated target gene expression.	Vitamin D	78-87	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	12-18
25500070-9	2015	Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect.	Vitamin D	146-155	hydroxysteroid (17-beta) dehydrogenase 2	Rattus norvegicus	84-91
25597951-9	2015	Consistent with this, vitamin D-induced expression of transient receptor potential cation channel, subfamily V, member 6 mRNA was reduced in the colon of CAC; APC(Delta580/Delta580) mice.	Vitamin D	22-31	APC, WNT signaling pathway regulator	Mus musculus	159-162
25597952-5	2015	Statistically significant proportional tissue increases in the vitamin D group relative to the placebo group were found in bax (51%), p21 (141%), APC (48%), E-cadherin (78%), MSH2 (179%), the CaSR (39%), and CYP27B1 (159%).	Vitamin D	63-72	H3 histone pseudogene 16	Homo sapiens	134-137
25730676-1	2015	1,25 Dihydroxyvitamin D3 (1,25D) is a hormone produced from vitamin D through two hydroxylating steps catalyzed successively in the liver by the vitamin D 25-hydroxylase Cyp2R1 and in the kidney by the 25-hydroxyvitamin D3 1alpha-hydroxylase Cyp27B1.	Vitamin D	14-23	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	145-169
25730676-1	2015	1,25 Dihydroxyvitamin D3 (1,25D) is a hormone produced from vitamin D through two hydroxylating steps catalyzed successively in the liver by the vitamin D 25-hydroxylase Cyp2R1 and in the kidney by the 25-hydroxyvitamin D3 1alpha-hydroxylase Cyp27B1.	Vitamin D	14-23	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	170-176
25730676-9	2015	However, the fate of Cyp2R1 that catalyzes the first enzymatic reaction of the vitamin D metabolism has not received attention.	Vitamin D	79-88	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	21-27
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	51-57
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	82-89
24620922-7	2015	RESULTS: Vitamin D deficiency (&lt;20 ng mL(-1) ) was found in 72.3% of subjects, but FGF-23 levels were normal [74 (58-97) RU per mL].	Vitamin D	9-18	L1 cell adhesion molecule	Mus musculus	41-47
25448751-14	2015	Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	39-45
25519225-0	2015	Genetic mutation of p53 and suppression of the miR-17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling.	Vitamin D	139-148	miR-17-92a-1 cluster host gene	Homo sapiens	47-56
25519225-7	2015	Mechanistic studies indicated that the selective toxicity of miR-17~92 polycistron inactivation was the consequence of derepression of vitamin D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1alpha,25-dihydroxyvitamin D3 metabolic pathway.	Vitamin D	135-144	miR-17-92a-1 cluster host gene	Homo sapiens	61-70
24274704-0	2013	Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.	Vitamin D	0-9	sphingosine-1-phosphate phosphatase 2	Homo sapiens	21-26
25336523-1	2014	Despite the presence of vitamin D receptor (VDR) in endothelial cells, the effect of vitamin D on endothelial function is unknown.	Vitamin D	24-33	vitamin D receptor	Rattus norvegicus	44-47
24274704-8	2013	CONCLUSIONS: SGPP2, a sphingosine-1-phosphate phosphatase, is a novel vitamin D-responsive gene associated with lung function.	Vitamin D	70-79	sphingosine-1-phosphate phosphatase 2	Homo sapiens	13-18
24628370-1	2014	BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG) could have opposing effects on cancer risk, as mutations are associated with both 10% higher serum vitamin D levels, which may protect against cancer, and with impaired skin barrier function, which may lead to higher cancer susceptibility.	Vitamin D	166-175	filaggrin	Homo sapiens	46-55
24076413-0	2013	1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration?	Vitamin D	14-23	HtrA serine peptidase 1	Macaca mulatta	34-39
24628370-1	2014	BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG) could have opposing effects on cancer risk, as mutations are associated with both 10% higher serum vitamin D levels, which may protect against cancer, and with impaired skin barrier function, which may lead to higher cancer susceptibility.	Vitamin D	166-175	filaggrin	Homo sapiens	62-65
25290078-3	2014	Treatment of day 5 zebrafish larvae with inactive 25D (5-150 nM) or active 1,25D (0.1-10 nM) induced dose responsive expression (15-95-fold) of the vitamin D-target gene cyp24a1 relative to larvae treated with vehicle, suggesting the presence of Cyp27b1 activity.	Vitamin D	148-157	cytochrome P450, family 24, subfamily A, polypeptide 1	Danio rerio	170-177
25346170-2	2014	Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal inflammation and ossification (involving cytokines such as IL-23 and sclerostin).	Vitamin D	36-45	interleukin 23 subunit alpha	Homo sapiens	199-204
25208829-4	2014	In addition, a novel association was observed at age 6 with SNPs on chromosome 7p15 near NPY (age 6: rs156299, P=1.3 x 10(-6)) that could be of functional interest in highlighting alternative pathways for vitamin D metabolism in this age group and merits further analysis in other cohort studies.	Vitamin D	205-214	neuropeptide Y	Homo sapiens	89-92
25405862-0	2014	Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	101-107
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	77-86	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	145-198
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	77-86	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	200-206
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	345-354	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	145-198
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	345-354	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	200-206
25405862-10	2014	Interestingly, two of the CYP2R1 SNPs (rs10500804 and rs12794714) and one GC SNP (rs1155563) were found to correlate with vitamin D in Arab population exclusively signifying their importance in this population.	Vitamin D	122-131	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	26-32
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	nuclear receptor coactivator 3	Homo sapiens	140-145
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	nuclear receptor corepressor 1	Homo sapiens	261-266
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	tumor protein p53 binding protein 1	Homo sapiens	268-275
25252917-0	2014	Vitamin D suppresses leptin stimulation of cancer growth through microRNA.	Vitamin D	0-9	leptin	Homo sapiens	21-27
25312721-0	2014	Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts.	Vitamin D	12-21	leptin	Homo sapiens	48-54
24128439-0	2014	DNA methylation levels of CYP2R1 and CYP24A1 predict vitamin D response variation.	Vitamin D	53-62	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	26-32
24128439-12	2014	Our findings indicate that baseline DNA methylation levels of CYP2R1 and CYP24A1 may predict vitamin D response variation.	Vitamin D	93-102	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	62-68
25356124-0	2014	Ribavirin induced anaemia: the effect of vitamin D supplementation on erythropoietin and erythrocyte indices in normal Wistar rat.	Vitamin D	41-50	erythropoietin	Rattus norvegicus	70-84
24630484-9	2014	CONCLUSIONS: Based on the increased expression of ICAM-1, MAdCAM-1 and MMP-2,-9,-3 in IBD, our study suggests that vitamin D derivatives may be effective in the management of these diseases.	Vitamin D	115-124	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	58-66
25143364-5	2014	Weighted gene coexpression network analysis revealed an association between the cytokine interleukin-32 (IL-32) and the vitamin D antimicrobial pathway in a network of interferon-gamma- and IL-15-induced "defense response" genes.	Vitamin D	120-129	interleukin 32	Homo sapiens	105-110
25143364-6	2014	IL-32 induced the vitamin D-dependent antimicrobial peptides cathelicidin and DEFB4 and to generate antimicrobial activity in vitro, dependent on the presence of adequate 25-hydroxyvitamin D. In addition, the IL-15-induced defense response macrophage gene network was integrated with ranked pairwise comparisons of gene expression from five different clinical data sets of latent compared with active tuberculosis or healthy controls and a coexpression network derived from gene expression in patients with tuberculosis undergoing chemotherapy.	Vitamin D	18-27	interleukin 32	Homo sapiens	0-5
24622764-9	2014	On the other hand, patients who underwent SG showed significantly increased ICTP levels (P &lt; 0.05), and the change in OPN was positively correlated with the change in ICTP and negatively with the change in vitamin D after surgery (P &lt; 0.05).	Vitamin D	209-218	secreted phosphoprotein 1	Homo sapiens	121-124
24756047-7	2014	For clinical cardiovascular risk factors, mutivariable regression analyses showed that low vitamin D level was best predictor of c-IMT.	Vitamin D	91-100	CIMT	Homo sapiens	129-134
24917821-2	2014	Vitamin D- and p53-signaling pathways have a significant impact on spontaneous or carcinogen-induced malignant transformation of cells, with VDR and p53 representing important tumor suppressors.	Vitamin D	0-9	transformation related protein 53, pseudogene	Mus musculus	149-152
24917821-9	2014	A third level of interaction is documented by the ability of vitamin D compounds to regulate the expression of the murine double minute 2 (MDM2) gene in dependence of the presence of wild-type p53.	Vitamin D	61-70	transformed mouse 3T3 cell double minute 2	Mus musculus	115-137
24917821-9	2014	A third level of interaction is documented by the ability of vitamin D compounds to regulate the expression of the murine double minute 2 (MDM2) gene in dependence of the presence of wild-type p53.	Vitamin D	61-70	transformed mouse 3T3 cell double minute 2	Mus musculus	139-143
24917821-9	2014	A third level of interaction is documented by the ability of vitamin D compounds to regulate the expression of the murine double minute 2 (MDM2) gene in dependence of the presence of wild-type p53.	Vitamin D	61-70	transformation related protein 53, pseudogene	Mus musculus	193-196
24686054-3	2014	The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing, and immune response of murine microglial cultures after stimulation with the Toll-like receptor (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), poly(I C) (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9).	Vitamin D	65-74	toll-like receptor 3	Mus musculus	300-304
24693993-0	2014	Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.	Vitamin D	25-34	collectrin, amino acid transport regulator	Rattus norvegicus	0-6
24693993-0	2014	Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.	Vitamin D	25-34	insulin 1	Rattus norvegicus	38-43
24693993-2	2014	Analysis of the INS-1 cell proteome using stable isotope labeling by amino acids in cell culture (SILAC) in combination with LC-MS identified Tmem27 as the one of most robustly (up to seven-fold) upregulated proteins after treatment with the active metabolite of vitamin D, 1,25-(OH)2D3.	Vitamin D	263-272	insulin 1	Rattus norvegicus	16-21
24693993-2	2014	Analysis of the INS-1 cell proteome using stable isotope labeling by amino acids in cell culture (SILAC) in combination with LC-MS identified Tmem27 as the one of most robustly (up to seven-fold) upregulated proteins after treatment with the active metabolite of vitamin D, 1,25-(OH)2D3.	Vitamin D	263-272	collectrin, amino acid transport regulator	Rattus norvegicus	142-148
25031721-7	2014	Real-time PCR analysis indicated that, when TGF-beta1 was over-expressed in diabetic nephropathy, the expressions of MCP-1 and CTGF were also up-regulated, which would be decreased by the treatment of vitamin D.	Vitamin D	201-210	cellular communication network factor 2	Rattus norvegicus	127-131
25031721-8	2014	On the other hand, when TGF-beta1 was interfered in DN, the expressions of MCP-1 and CTGF were relatively down-regulated, which would be further lowered by vitamin D administration.	Vitamin D	156-165	cellular communication network factor 2	Rattus norvegicus	85-89
25031721-9	2014	The mRNA expression of VDR was elevated by vitamin D treatment in these diabetic nephropathy models.	Vitamin D	43-52	vitamin D receptor	Rattus norvegicus	23-26
24562971-7	2014	RESULTS: A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels.	Vitamin D	100-109	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	130-136
24606102-5	2014	OBJECTIVE: The objective of the study was to evaluate the effect of 1,25 dihydroxyvitamin D3 (vit D3) supplementation on serum sRAGE and AMH in vitamin D-deficient women with PCOS.	Vitamin D	82-91	anti-Mullerian hormone	Homo sapiens	137-140
24808866-7	2014	Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation.	Vitamin D	31-40	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	141-147
24619416-0	2014	Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4.	Vitamin D	0-9	thioesterase superfamily member 4	Mus musculus	75-108
24619416-7	2014	A functional vitamin D-responsive element in the THEM4 promoter was identified by chromatin immunoprecipitation and luciferase reporter assay.	Vitamin D	13-22	thioesterase superfamily member 4	Mus musculus	49-54
24497297-3	2014	Cytochrome P450 2R1 (CYP2R1) is a microsomal vitamin D 25-hydroxylase which plays an important role in converting dietary vitamin D to active metabolite, 25-(OH)D3.	Vitamin D	45-54	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-19
24497297-3	2014	Cytochrome P450 2R1 (CYP2R1) is a microsomal vitamin D 25-hydroxylase which plays an important role in converting dietary vitamin D to active metabolite, 25-(OH)D3.	Vitamin D	45-54	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	21-27
25097830-10	2014	Further, we show that high-dose vitamin D therapy impacts systemic hepcidin levels in subjects with early stage CKD.	Vitamin D	32-41	hepcidin antimicrobial peptide	Homo sapiens	67-75
25097830-11	2014	These data suggest that improvement in vitamin D status is associated with lower systemic concentrations of hepcidin in subjects with CKD.	Vitamin D	39-48	hepcidin antimicrobial peptide	Homo sapiens	108-116
25097830-12	2014	In conclusion, vitamin D regulates the hepcidin-ferroportin axis in macrophages which may facilitate iron egress.	Vitamin D	15-24	hepcidin antimicrobial peptide	Homo sapiens	39-47
25097830-13	2014	Improvement in vitamin D status in patients with CKD may reduce systemic hepcidin levels and may ameliorate anemia of CKD.	Vitamin D	15-24	hepcidin antimicrobial peptide	Homo sapiens	73-81
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Vitamin D	194-203	fibroblast growth factor 15	Mus musculus	41-44
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Vitamin D	194-203	fibroblast growth factor 15	Mus musculus	77-85
24468256-8	2014	Transcription factors PU.1 and interferon regulatory factor 4 were downregulated by vitamin D but not GATA3 and c-MAF.	Vitamin D	84-93	Spi-1 proto-oncogene	Homo sapiens	22-26
24313624-0	2014	Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells.	Vitamin D	5-14	CD38 molecule	Homo sapiens	44-48
25506471-2	2014	More recently hnRNP C has also been shown to function as a DNA binding protein exerting a dominant-negative effect on transcriptional responses to the vitamin D hormone,1,25-dihydroxyvitamin D (1,25(OH)2D), via interaction in cis with vitamin D response elements (VDREs).	Vitamin D	151-160	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	14-21
25506471-2	2014	More recently hnRNP C has also been shown to function as a DNA binding protein exerting a dominant-negative effect on transcriptional responses to the vitamin D hormone,1,25-dihydroxyvitamin D (1,25(OH)2D), via interaction in cis with vitamin D response elements (VDREs).	Vitamin D	183-192	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	14-21
24200978-0	2014	Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese.	Vitamin D	18-27	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	62-68
24734087-0	2014	Plasma Vitamin D Status and Its Correlation with Risk Factors of Thrombosis, P-selectin and hs-CRP Level in Patients with Venous Thromboembolism; the First Study of Iranian Population.	Vitamin D	7-16	selectin P	Homo sapiens	77-87
24734087-3	2014	To the best of our knowledge, this was the first investigation on venous thromboembolism (VTE) subjects that assessed the correlation of vitamin D level with plasma P-selectin, hs-CRP, and risk factors of thrombosis.	Vitamin D	137-146	selectin P	Homo sapiens	165-175
24284821-0	2014	Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice.	Vitamin D	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	28-61
24192346-3	2014	The aim of our study is to elucidate the impact of 25(OH) vitamin D3 on amyloid precursor protein processing in mice and N2A cells utilizing very moderate and physiological vitamin D hypovitaminosis in the range of 20-30% compared to wild-type mice.	Vitamin D	58-67	amyloid beta (A4) precursor protein	Mus musculus	72-97
24192346-5	2014	Additionally, neprilysin (NEP) expression is downregulated resulting in a decreased NEP activity further enhancing the effect of decreased vitamin D on the Abeta level.	Vitamin D	139-148	amyloid beta (A4) precursor protein	Mus musculus	156-161
23813327-6	2013	Our results indicate that vitamin D has protective effects on diabetes-induced aortic injury and attenuates the expressions of TLR4, MyD88, and NF-kappaB in diabetic rats.	Vitamin D	26-35	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	133-138
23789983-2	2013	Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF-I serum values in population-based cohorts of healthy subjects.	Vitamin D	0-9	insulin like growth factor binding protein 3	Homo sapiens	59-66
24007780-5	2013	Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06).	Vitamin D	10-19	C-C motif chemokine ligand 2	Homo sapiens	112-117
23789983-3	2013	The modulation of IGF-I and IGFBP-3 concentrations by vitamin D may impact recombinant human (rh) GH dosing for the treatment of GHD.	Vitamin D	54-63	insulin like growth factor binding protein 3	Homo sapiens	28-35
23859635-4	2013	The goal of this survey was to investigate the relation between vitamin D level and level of PAI-1 as a thrombotic marker.	Vitamin D	64-73	serpin family E member 1	Homo sapiens	93-98
23250517-0	2013	Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	68-71
23250517-0	2013	Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement.	Vitamin D	58-67	vitamin D receptor	Rattus norvegicus	68-71
23250517-1	2013	Vitamin D receptor (VDR) and the enzymes involved in bioactivation of vitamin D, shown to be expressed in the central nervous system, particularly in areas affected by neurodegenerative disorders, especially in hippocampus.	Vitamin D	70-79	vitamin D receptor	Rattus norvegicus	0-18
23250517-1	2013	Vitamin D receptor (VDR) and the enzymes involved in bioactivation of vitamin D, shown to be expressed in the central nervous system, particularly in areas affected by neurodegenerative disorders, especially in hippocampus.	Vitamin D	70-79	vitamin D receptor	Rattus norvegicus	20-23
23250517-12	2013	Higher gene expression of 24OHase and VDR might indicate "higher requirement of vitamin D" in hippocampus and potential consequences of vitamin D deficiency in cognitive decline, neurodegeneration, and Alzheimer"s disease.	Vitamin D	80-89	vitamin D receptor	Rattus norvegicus	38-41
23250517-12	2013	Higher gene expression of 24OHase and VDR might indicate "higher requirement of vitamin D" in hippocampus and potential consequences of vitamin D deficiency in cognitive decline, neurodegeneration, and Alzheimer"s disease.	Vitamin D	136-145	vitamin D receptor	Rattus norvegicus	38-41
23837623-9	2013	In contrast, CYP2R1, which 25-hydroxylates vitamin D, is under balancing selection and we found no evidence of recent selection pressure on GC, which is responsible for vitamin D transport.	Vitamin D	43-52	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	13-19
23906633-6	2013	Here we show, using human patient samples from individuals with hereditary vitamin D resistant rickets, that the VDR directly inhibits the expression of uncoupling protein-1 (UCP1), the critical protein for uncoupling fatty acid oxidation in brown fat and burning energy.	Vitamin D	75-84	uncoupling protein 1	Homo sapiens	153-179
23669253-13	2013	Therefore, we concluded that vitamin D may play a pivotal role in exercise-induced muscle damage and inflammation through the modulation of MAPK and NF-kappaB involved with VDR.	Vitamin D	29-38	vitamin D receptor	Rattus norvegicus	173-176
23636220-4	2013	Single-nucleotide polymorphisms (SNPs) in the DHCR7/NADSYN1 (nicotinamide adenine dinucleotide synthase 1) and CYP2R1 loci, previously associated with circulating vitamin D levels, were tested in UK RA cases (n=3870) and controls (n=8430).	Vitamin D	163-172	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	111-117
23274116-2	2013	In order to further explore this class of pharmacologically important vitamin D compounds we have decided to synthesize analogs characterized by the presence of two A-ring exocyclic methylene groups attached to C-2 and C-10.	Vitamin D	70-79	complement C2	Homo sapiens	211-214
23410597-1	2013	As a continuation of our studies on structure-activity relationship of vitamin D compounds we synthesized new calcitriol analogs characterized by the presence of an exomethylene substituent at C-2.	Vitamin D	71-80	complement C2	Homo sapiens	193-196
23416104-0	2013	Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone.	Vitamin D	35-44	complement C2	Homo sapiens	19-22
23416104-2	2013	In our previous paper, we reported the synthesis of various C-2 substituted vitamin D derivatives (2b-2i) with a 2,2-dimethylcyclopentanone unit in the CD-ring side chains, and that the derivatives have strong activity for enhancing bone growth.	Vitamin D	76-85	complement C2	Homo sapiens	60-63
23319826-6	2013	RESULTS: In a linear regression model adjusting for month of blood sampling, age, and sex, vitamin D concentrations were predicted by GC genotype (P &lt; 0.001), CYP2R1 genotype (P = 0.068), and DHCR7 genotype (P &lt; 0.001), with a coefficient of determination (r(2)) of 0.175.	Vitamin D	91-100	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	162-168
23439304-2	2013	It has been shown that vitamin D deficiency is associated with increased OX40L expression in peripheral CD11c(+) cells and controls Th2 responses to Aspergillus fumigatus in vitro in cystic fibrosis (CF) patients with allergic bronchopulmonary aspergillosis (ABPA).	Vitamin D	23-32	TNF superfamily member 4	Homo sapiens	73-78
23439304-5	2013	In in vitro assays, vitamin D treatment led to vitamin D receptor (VDR) binding in the promoter region of OX40L and significantly decreased the promoter activity of the OX40L promoter.	Vitamin D	20-29	TNF superfamily member 4	Homo sapiens	106-111
23439304-5	2013	In in vitro assays, vitamin D treatment led to vitamin D receptor (VDR) binding in the promoter region of OX40L and significantly decreased the promoter activity of the OX40L promoter.	Vitamin D	20-29	TNF superfamily member 4	Homo sapiens	169-174
23439304-6	2013	In addition, vitamin D altered NF-kappaB p50 binding in the OX40L promoter that may be responsible for repression of OX40L expression.	Vitamin D	13-22	TNF superfamily member 4	Homo sapiens	60-65
23439304-6	2013	In addition, vitamin D altered NF-kappaB p50 binding in the OX40L promoter that may be responsible for repression of OX40L expression.	Vitamin D	13-22	TNF superfamily member 4	Homo sapiens	117-122
23439304-7	2013	These data show that vitamin D can act directly on OX40L, which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX40L.	Vitamin D	21-30	TNF superfamily member 4	Homo sapiens	51-56
23439304-7	2013	These data show that vitamin D can act directly on OX40L, which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX40L.	Vitamin D	21-30	TNF superfamily member 4	Homo sapiens	157-162
23439304-7	2013	These data show that vitamin D can act directly on OX40L, which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX40L.	Vitamin D	122-131	TNF superfamily member 4	Homo sapiens	51-56
23439304-7	2013	These data show that vitamin D can act directly on OX40L, which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX40L.	Vitamin D	122-131	TNF superfamily member 4	Homo sapiens	157-162
23212742-1	2013	Long-term therapy with certain drugs, especially cytochrome P450 (P450; CYP)-inducing agents, confers an increased risk of osteomalacia that is attributed to vitamin D deficiency.	Vitamin D	158-167	peptidylprolyl isomerase G	Homo sapiens	72-75
23435685-3	2013	Vitamin D (vitD) and analogs have been shown to suppress TNF-alpha-induced IL-1alpha in human keratinocytes (KCs).	Vitamin D	0-9	interleukin 1 alpha	Homo sapiens	75-84
23109222-2	2013	Our hypothesis was that there is a relation between GH, IGF-I, and 25(OH)D; and that vitamin D supplementation may have an effect on the levels of GH, IGF-I, and IGF-I/IGFBP-3 ratio.	Vitamin D	85-94	insulin like growth factor binding protein 3	Homo sapiens	168-175
23109222-7	2013	Vitamin D status was an independent predictor of GH-IGF-I axis and supplementation with vitamin D decreased IGF-I/IGFBP-3 ratio in subjects without severe obesity.	Vitamin D	88-97	insulin like growth factor binding protein 3	Homo sapiens	114-121
23311753-5	2013	We performed cocultures of primary human mesenchymal stem cells (hMSCs) and human osteoblasts (hOBs) with myeloma cells, which resulted in an inhibition of the vitamin D-dependent differentiation of osteoblast precursors.	Vitamin D	160-169	leptin	Homo sapiens	95-99
23322908-4	2013	Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-beta peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression.	Vitamin D	0-9	heme oxygenase 1	Homo sapiens	205-221
22583563-5	2013	Serum 25(OH)D concentrations and genetic polymorphisms in vitamin D metabolism pathway enzymes (cytochrome P450 (CYP) 2R1, 3A4, 27B1, 24A1; vitamin D binding protein (also known as group-specific component, GC); and vitamin D receptor) were measured using stored biospecimens.	Vitamin D	58-67	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	96-121
23160964-2	2013	Vitamin D has been shown to regulate energy metabolism, but the relationship between vitamin D and leptin is unclear.	Vitamin D	85-94	leptin	Mus musculus	99-105
23160964-4	2013	To address this question, we determined the effect of vitamin D on leptin expression in vivo and ex vivo.	Vitamin D	54-63	leptin	Mus musculus	67-73
23160964-5	2013	One-week treatment of WT mice with the vitamin D analog RO-27-5646 led to a significant increase in adipose leptin mRNA transcript and serum leptin levels.	Vitamin D	39-48	leptin	Mus musculus	108-114
23160964-5	2013	One-week treatment of WT mice with the vitamin D analog RO-27-5646 led to a significant increase in adipose leptin mRNA transcript and serum leptin levels.	Vitamin D	39-48	leptin	Mus musculus	141-147
23320821-0	2013	Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study.	Vitamin D	25-34	lipoprotein lipase	Homo sapiens	0-18
23690781-9	2013	These results suggest a role for IGFBP-3 in 1, 25-D3 apoptotic signalling and that impaired secretion of IGFBP-3 may be involved in acquired resistance to vitamin D in breast cancer.	Vitamin D	155-164	insulin like growth factor binding protein 3	Homo sapiens	105-112
24358684-6	2013	Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production.	Vitamin D	0-9	interleukin 23 subunit alpha	Homo sapiens	35-40
24348557-6	2013	Various genetic factors and environmental factors such as obesity, smoking, and vitamin D deficiency which have been shown to correlate with serum AMH levels and also display significant racial/ethnic variations are discussed in this review.	Vitamin D	80-89	anti-Mullerian hormone	Homo sapiens	147-150
23232694-4	2013	We studied TFIIH-dependent transactivation by nuclear receptor for vitamin D (VDR) and thyroid in cells from these patients.	Vitamin D	67-76	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	11-16
23190755-0	2013	Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	61-67
23232694-5	2013	The vitamin D stimulation ratio of CYP24 and osteopontin was associated with specific pairs of mutations (reduced in 5, elevated in 1) but not correlated with distinct clinical phenotypes.	Vitamin D	4-13	secreted phosphoprotein 1	Homo sapiens	45-56
23923049-4	2013	The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues.	Vitamin D	66-75	thrombomodulin	Homo sapiens	19-33
23923049-4	2013	The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues.	Vitamin D	66-75	thrombomodulin	Homo sapiens	35-39
23923049-4	2013	The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues.	Vitamin D	138-147	thrombomodulin	Homo sapiens	19-33
23923049-4	2013	The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues.	Vitamin D	138-147	thrombomodulin	Homo sapiens	35-39
23923049-5	2013	However, in a ranking of the samples concerning their expected response to vitamin D only the top half showed a positive correlation between the changes of CD14 or THBD mRNA and serum 25(OH)D3 concentrations.	Vitamin D	75-84	thrombomodulin	Homo sapiens	164-168
23190755-7	2013	Two nonsynonymous SNPs in GC and 4 SNPs in CYP2R1 were strongly associated with 25(OH)D in individuals whose blood was drawn in summer (P &lt;= 0.002) but not winter months and, independently, in individuals with vitamin D intakes &gt;=400 (P &lt;= 0.004) but not &lt;400 IU/d (10 mug/d).	Vitamin D	213-222	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	43-49
23770363-0	2013	Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	116-121
24522025-9	2013	Vitamin D have direct effect on AMH production, and thus increase longer maintenance of ovarian reserve in the patients with its higher concentration.	Vitamin D	0-9	anti-Mullerian hormone	Homo sapiens	32-35
23877860-0	2013	LPS and HIV gp120 modulate monocyte/macrophage CYP27B1 and CYP24A1 expression leading to vitamin D consumption and hypovitaminosis D in HIV-infected individuals.	Vitamin D	89-98	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	12-17
23877860-3	2013	PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS).	Vitamin D	99-108	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	268-273
23169318-3	2013	We systemically evaluated the association of 89 tagging and candidate-based GSVs in six major vitamin D metabolism pathway genes (VDR, GC, CYP24A1, CYP27A1, CYP27B1 and CYP2R1) and the circulating serum vitamin D level with overall survival (OS) and second primary cancer (SPC) in 522 Stages I-II radiation-treated patients with HNC.	Vitamin D	94-103	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	148-155
23206285-2	2012	The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present.	Vitamin D	19-28	catenin beta 1	Homo sapiens	70-82
23169318-3	2013	We systemically evaluated the association of 89 tagging and candidate-based GSVs in six major vitamin D metabolism pathway genes (VDR, GC, CYP24A1, CYP27A1, CYP27B1 and CYP2R1) and the circulating serum vitamin D level with overall survival (OS) and second primary cancer (SPC) in 522 Stages I-II radiation-treated patients with HNC.	Vitamin D	94-103	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	169-175
23169318-8	2013	Serum vitamin D levels were significantly lower in patients carrying the minor alleles of GC:rs4588 and CYP2R1:rs10500804.	Vitamin D	6-15	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	104-110
23112173-10	2012	Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D.	Vitamin D	145-154	MAX dimerization protein 1	Mus musculus	43-47
22855339-0	2012	Mutation of the CYP2R1 vitamin D 25-hydroxylase in a Saudi Arabian family with severe vitamin D deficiency.	Vitamin D	23-32	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	16-22
22855339-1	2012	CONTEXT: Inherited forms of vitamin D deficiency are rare causes of rickets and to date have been traced to mutations in three genes, VDR, encoding the 1alpha,25-dihydroxyvitamin D receptor, CYP27B1, encoding the vitamin D 1alpha-hydroxylase, and CYP2R1, encoding a microsomal vitamin D 25-hydroxylase.	Vitamin D	28-37	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	247-253
22855339-1	2012	CONTEXT: Inherited forms of vitamin D deficiency are rare causes of rickets and to date have been traced to mutations in three genes, VDR, encoding the 1alpha,25-dihydroxyvitamin D receptor, CYP27B1, encoding the vitamin D 1alpha-hydroxylase, and CYP2R1, encoding a microsomal vitamin D 25-hydroxylase.	Vitamin D	28-37	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	277-301
23572530-0	2013	Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14.	Vitamin D	0-9	mediator complex subunit 14	Homo sapiens	129-156
22801813-0	2012	The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children.	Vitamin D	51-60	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	8-14
23548573-3	2013	In this study, we examined production of 25-hydroxylated vitamin D using whole recombinant yeast cells that expressed CYP2R1.	Vitamin D	57-66	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	118-124
23303458-6	2013	Vitamin D, another epidermal signal, enhanced TGF-beta1-mediated beta-catenin induction and promoted the expression of multiple epithelial genes by LCs.	Vitamin D	0-9	catenin beta 1	Homo sapiens	65-77
22801813-3	2012	Our objective was to identify the relationship among three vitamin D-related genes (GC, CYP2R1 and DHCR7/NADSYN1) and the levels of 25(OH)D in northeastern Han Chinese children.	Vitamin D	59-68	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	88-94
22508713-3	2012	The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels.	Vitamin D	33-42	anti-Mullerian hormone	Homo sapiens	4-7
23219444-10	2013	The genomic and epigenomic approach reinforce the crucial roles played by the DHCR7, CYP2R1, and CYP24A1 genes in vitamin D metabolism.	Vitamin D	114-123	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	85-91
23614044-0	2013	Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis.	Vitamin D	40-49	major histocompatibility complex, class I, B	Homo sapiens	78-85
22508713-3	2012	The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels.	Vitamin D	33-42	anti-Mullerian hormone	Homo sapiens	111-114
22508713-3	2012	The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels.	Vitamin D	75-84	anti-Mullerian hormone	Homo sapiens	4-7
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	C-C motif chemokine ligand 2	Homo sapiens	101-106
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	toll like receptor 4	Homo sapiens	136-141
22508713-3	2012	The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels.	Vitamin D	75-84	anti-Mullerian hormone	Homo sapiens	111-114
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	toll like receptor 5	Homo sapiens	147-152
22508713-11	2012	Change in AMH level correlated with the initial AMH level and the magnitude of change in vitamin D levels (r = 0.36, P = 0.004).	Vitamin D	89-98	anti-Mullerian hormone	Homo sapiens	10-13
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	43-48
23012315-7	2013	Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta.	Vitamin D	29-38	C-C motif chemokine ligand 2	Homo sapiens	49-54
22508713-13	2012	CONCLUSION: Vitamin D may be a positive regulator of AMH production in adults, and vitamin D deficiency may confound clinical decisions based on AMH.	Vitamin D	12-21	anti-Mullerian hormone	Homo sapiens	53-56
23012315-7	2013	Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta.	Vitamin D	29-38	toll like receptor 4	Homo sapiens	56-61
22334534-3	2012	Vitamin D contributes to pulmonary health and promotes regulatory immune pathways, therefore its influence on CD200 and CD200R was investigated.	Vitamin D	0-9	CD200 molecule	Homo sapiens	110-115
23337117-5	2013	Importantly, depletion or inhibition of CTSL with vitamin D or specific inhibitors stabilized 53BP1 and increased genomic instability in response to radiation and poly(adenosine diphosphate-ribose) polymerase inhibitors, compromising proliferation.	Vitamin D	50-59	tumor protein p53 binding protein 1	Homo sapiens	94-99
22334534-10	2012	CONCLUSIONS: The capacity of 1alpha,25-dihydroxyvitamin D3 to induce CD200 expression by peripheral and respiratory tract T cells identifies an additional pathway via which vitamin D can restrain inflammation in the airways to maintain respiratory health.	Vitamin D	48-57	CD200 molecule	Homo sapiens	69-74
23160964-7	2013	These data demonstrate that 1,25-dihydroxyvitamin D stimulates adipose leptin production in a VDR-dependent manner, suggesting that vitamin D may affect energy homeostasis through direct regulation of leptin expression.	Vitamin D	42-51	leptin	Mus musculus	71-77
22520928-11	2012	In contrast, a high concentration of calcitriol (1,25-dihydroxyvitamin D(3), the active form of vitamin D(3)) or its analog MC903 upregulated total TSLP significantly but not the long-form, and did not induce the release of TSLP.	Vitamin D	63-72	thymic stromal lymphopoietin	Homo sapiens	148-152
23160964-7	2013	These data demonstrate that 1,25-dihydroxyvitamin D stimulates adipose leptin production in a VDR-dependent manner, suggesting that vitamin D may affect energy homeostasis through direct regulation of leptin expression.	Vitamin D	42-51	leptin	Mus musculus	201-207
22499501-5	2012	We selected 97 single-nucleotide polymorphisms (SNPs) in genomic regions with high linkage disequilibrium (tagSNPs) to represent common genetic variation among seven vitamin D-related genes (CYP27A1, CYP2R1, CYP27B1, GC, CYP24A1, RXRA, and VDR).	Vitamin D	166-175	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	191-198
23149414-0	2013	Vitamin D directly regulates Mdm2 gene expression in osteoblasts.	Vitamin D	0-9	transformed mouse 3T3 cell double minute 2	Mus musculus	29-33
23607098-0	2013	In vivo determination of vitamin d function using transgenic mice carrying a human osteocalcin luciferase reporter gene.	Vitamin D	25-34	bone gamma-carboxyglutamate protein 2	Mus musculus	83-94
22785457-4	2012	In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels.	Vitamin D	99-108	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	152-158
23752060-2	2013	The aim of this study was to determine the expression of the vitamin D receptor (VDR), 25-hydroxyvitamin D3 24-hydroxylase (an accelerator of vitamin D catabolism), and the L-type voltage-sensitive calcium channel A1C (LVSCC-A1C) in hippocampal neurons in response to beta amyloid and vitamin D treatments to test the protective effects of vitamin D and the probable effects of beta amyloid on vitamin D catabolism.	Vitamin D	61-70	vitamin D receptor	Rattus norvegicus	81-84
23752060-5	2013	CONCLUSION: Beta amyloid may disrupt the vitamin D-VDR pathway and cause defective utilization of vitamin D by suppressing the level of the VDR and elevating the level of 24OHase.	Vitamin D	41-50	vitamin D receptor	Rattus norvegicus	51-54
21710586-0	2012	Serum inverts and improves the fluorescence response of an aptamer beacon to various vitamin D analytes.	Vitamin D	85-94	ubiquitin like 5	Homo sapiens	67-73
23752060-5	2013	CONCLUSION: Beta amyloid may disrupt the vitamin D-VDR pathway and cause defective utilization of vitamin D by suppressing the level of the VDR and elevating the level of 24OHase.	Vitamin D	98-107	vitamin D receptor	Rattus norvegicus	140-143
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	10-19	CD83 molecule	Homo sapiens	101-105
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	55-64	CD83 molecule	Homo sapiens	101-105
21710586-2	2012	The aptamer beacon exhibited a mild "lights on" reaction in buffer as a function of increasing concentrations of several vitamin D analogues and metabolites, with a limit of detection of approximately 200 ng/mL, and was not specific for any particular congener.	Vitamin D	121-130	ubiquitin like 5	Homo sapiens	12-18
23043189-12	2012	However, in patients with vitamin D deficiency, an approximately 25% greater fall in the bone resorption marker CTX is seen with its administration.	Vitamin D	26-35	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	112-115
21710586-4	2012	We hypothesized that this drastic change in fluorescence behaviour was due to the presence of creatinine and urea in serum, which might destabilize the quenched beacon, causing an increase in fluorescence followed by decreasing fluorescence as a function of vitamin D concentrations that may bind and quench increasingly greater fractions of the denatured beacons.	Vitamin D	258-267	ubiquitin like 5	Homo sapiens	161-167
22035960-1	2011	In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status.	Vitamin D	149-158	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	30-34
23012375-4	2012	Vitamin D-sufficient patients (&gt;=30 ng/ml 25(OH)D) had lower monocyte endoplasmic reticulum (ER) stress, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of monocyte adhesion molecules PSGL-1, beta(1)-integrin, and beta(2)-integrin compared with patients with 25(OH)D levels of &lt;30 ng/ml.	Vitamin D	0-9	selectin P ligand	Homo sapiens	229-235
21750527-7	2011	Furthermore, we demonstrate that treatment with vitamin D stabilizes 53BP1 and promotes DNA DSBs repair via inhibition of CTSL, providing an as yet unsuspected link between vitamin D action and DNA repair.	Vitamin D	48-57	tumor protein p53 binding protein 1	Homo sapiens	69-74
21654390-3	2011	RECENT FINDINGS: Findings from large-scale genome-wide association meta-analyses on 25(OH)D confirmed the associations for loci nearby genes encoding vitamin D binding protein (GC, group component), 7-dehydrochlesterol reductase (DHCR7), 25-hydroxylase (CYP2R1) and 24-hydroxylase (CYP24A1), all influencing key sites for vitamin D metabolism.	Vitamin D	150-159	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	254-260
21419242-12	2011	However, in vitamin D-treated primary rat osteoblast cells E+RLX increased OPG protein and reduced the RANKL/OPG protein ratio.	Vitamin D	12-21	TNF receptor superfamily member 11B	Rattus norvegicus	75-78
21419242-12	2011	However, in vitamin D-treated primary rat osteoblast cells E+RLX increased OPG protein and reduced the RANKL/OPG protein ratio.	Vitamin D	12-21	TNF receptor superfamily member 11B	Rattus norvegicus	109-112
21605467-0	2011	Predominance of Th2 polarization by vitamin D through a STAT6-dependent mechanism.	Vitamin D	36-45	heart and neural crest derivatives expressed 2	Mus musculus	16-19
21605467-1	2011	BACKGROUND: Vitamin D has several reported immunomodulatory properties including the reduced generation of pro-inflammatory CD4+ T helper 1 (Th1) cells and the increase in levels of the anti-inflammatory Th2 subset.	Vitamin D	12-21	heart and neural crest derivatives expressed 2	Mus musculus	204-207
21605467-5	2011	RESULTS: We report that the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 {1,25(OH)2D3}, consistently generates human and murine Th2 cells in culture, frequently leaving unchanged the levels of Th1/Th17 cytokines.	Vitamin D	56-65	heart and neural crest derivatives expressed 2	Mus musculus	147-150
21605467-10	2011	CONCLUSIONS: These results of vitamin D promoting a Th2 shift through upstream GATA-3 and STAT6 transcription factors shed mechanistic understanding on the utility of vitamin D in MS.	Vitamin D	30-39	heart and neural crest derivatives expressed 2	Mus musculus	52-55
21605467-10	2011	CONCLUSIONS: These results of vitamin D promoting a Th2 shift through upstream GATA-3 and STAT6 transcription factors shed mechanistic understanding on the utility of vitamin D in MS.	Vitamin D	30-39	GATA binding protein 3	Mus musculus	79-85
21605467-10	2011	CONCLUSIONS: These results of vitamin D promoting a Th2 shift through upstream GATA-3 and STAT6 transcription factors shed mechanistic understanding on the utility of vitamin D in MS.	Vitamin D	167-176	heart and neural crest derivatives expressed 2	Mus musculus	52-55
21605467-10	2011	CONCLUSIONS: These results of vitamin D promoting a Th2 shift through upstream GATA-3 and STAT6 transcription factors shed mechanistic understanding on the utility of vitamin D in MS.	Vitamin D	167-176	GATA binding protein 3	Mus musculus	79-85
21463608-9	2011	However, when vitamin D(3) was constantly treated, the BMP was more effective when treated for the last 7 days than when treated for the first 7 days.	Vitamin D	14-23	bone morphogenetic protein 1	Homo sapiens	55-58
21289245-8	2011	TGF-beta3 also induced protein expression of plasminogen activator inhibitor-1, an important TGF-beta target, in HuLM cells, which was also inhibited by vitamin D(3).	Vitamin D	153-162	serpin family E member 1	Homo sapiens	45-78
21350098-8	2011	Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P &lt; .05).	Vitamin D	19-28	toll like receptor 4	Homo sapiens	82-86
21067507-6	2011	Emerging experimental data suggest that vitamin D may protect podocytes by targeting multiple pathways, including the renin-angiotensin system, Wnt/beta-catenin pathway and pro-apoptotic pathway.	Vitamin D	40-49	catenin beta 1	Homo sapiens	148-160
20736132-11	2011	Vitamin D inhibited extracellular signal-regulated kinase activation and down-regulated the expression of BCL-2, BCL-w, CDK1, and PCNA.	Vitamin D	0-9	cyclin dependent kinase 1	Homo sapiens	120-124
20736132-11	2011	Vitamin D inhibited extracellular signal-regulated kinase activation and down-regulated the expression of BCL-2, BCL-w, CDK1, and PCNA.	Vitamin D	0-9	proliferating cell nuclear antigen	Homo sapiens	130-134
22111014-3	2011	There are still too few conclusive reports about conspicuous vitamin D metabolism according to pancreatic fecal elastase 1 (FE1) in obese patients.	Vitamin D	61-70	chymotrypsin like elastase 3B	Homo sapiens	106-122
22111014-3	2011	There are still too few conclusive reports about conspicuous vitamin D metabolism according to pancreatic fecal elastase 1 (FE1) in obese patients.	Vitamin D	61-70	chymotrypsin like elastase 3B	Homo sapiens	124-127
22111014-12	2011	In obese females, pancreatic FE1 in feces confirms the extent of vitamin D supply, and thus shows a vitamin D(3) deficiency, depending on the loss of stool content.	Vitamin D	65-74	chymotrypsin like elastase 3B	Homo sapiens	29-32
22111014-12	2011	In obese females, pancreatic FE1 in feces confirms the extent of vitamin D supply, and thus shows a vitamin D(3) deficiency, depending on the loss of stool content.	Vitamin D	100-109	chymotrypsin like elastase 3B	Homo sapiens	29-32
20969950-2	2011	We analyzed female rat dorsal root ganglia (DRG) for vitamin receptor (VDR) and the vitamin D metabolizing enzymes CYP27B1 and CYP24.	Vitamin D	84-93	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	115-122
20969950-6	2011	In addition, local vitamin D metabolite concentrations in unmyelinated sensory neurons may be controlled through expression of CYP27B1 and CYP24.	Vitamin D	19-28	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	127-134
20649944-0	2011	Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. In immune-competent patients, higher vitamin D levels predicted sustained viral response (SVR) following interferon (INF) and ribavirin therapy for chronic hepatitis C. This study aimed to verify the influence of vitamin D serum levels and/or vitamin D supplementation in predicting SVR rates for recurrent hepatitis C (RHC).	Vitamin D	0-9	cobalamin binding intrinsic factor	Homo sapiens	199-215
20649944-0	2011	Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. In immune-competent patients, higher vitamin D levels predicted sustained viral response (SVR) following interferon (INF) and ribavirin therapy for chronic hepatitis C. This study aimed to verify the influence of vitamin D serum levels and/or vitamin D supplementation in predicting SVR rates for recurrent hepatitis C (RHC).	Vitamin D	131-140	cobalamin binding intrinsic factor	Homo sapiens	199-215
20688883-6	2010	RESULTS: Higher leptin levels were associated with higher PTH and lower vitamin D levels, and adjustment for vitamin D attenuated the association between leptin and PTH.	Vitamin D	72-81	leptin	Homo sapiens	16-22
20688883-6	2010	RESULTS: Higher leptin levels were associated with higher PTH and lower vitamin D levels, and adjustment for vitamin D attenuated the association between leptin and PTH.	Vitamin D	109-118	leptin	Homo sapiens	154-160
20081878-8	2010	Exposure to vitamin D resulted in increased expression of IDO, an enzyme responsible for tryptophan metabolism that is upregulated in tolerizing DCs.	Vitamin D	12-21	indoleamine 2,3-dioxygenase 1	Homo sapiens	58-61
20531451-4	2010	As expected, CYP24 decreased whereas CYP27B1 increased when normal animals were rendered vitamin D deficient.	Vitamin D	89-98	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	37-44
20488884-1	2010	A central paradox of vitamin D biology is that 1alpha,25-(OH)(2) D(3) exposure inversely relates to colorectal cancer (CRC) risk despite a capacity for activation of both pro- and anti-oncogenic mediators including osteopontin (OPN)/CD44 and E-cadherin, respectively.	Vitamin D	21-30	secreted phosphoprotein 1	Homo sapiens	215-226
20488884-1	2010	A central paradox of vitamin D biology is that 1alpha,25-(OH)(2) D(3) exposure inversely relates to colorectal cancer (CRC) risk despite a capacity for activation of both pro- and anti-oncogenic mediators including osteopontin (OPN)/CD44 and E-cadherin, respectively.	Vitamin D	21-30	secreted phosphoprotein 1	Homo sapiens	228-231
20334872-3	2010	Vitamin D inhibits growth of canine mast cell tumours (MCTs) in vitro, presumably due to ligand-mediated activation of the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Canis lupus familiaris	123-141
20334872-3	2010	Vitamin D inhibits growth of canine mast cell tumours (MCTs) in vitro, presumably due to ligand-mediated activation of the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Canis lupus familiaris	143-146
20647695-7	2010	Vitamin D increased calcium staining in thoracic aortas and hearts and the expression levels of osteopontin and osteocalcin in mice.	Vitamin D	0-9	bone gamma-carboxyglutamate protein 2	Mus musculus	112-123
20036769-7	2010	Examples of LC1/MS2 analyses of triacylglycerols (TAGs), sphingolipids, and vitamin D are given, as well as an example of an LC2/MS2 experiment that is used to perform analysis of both polar and non-polar lipids in a total lipid extract.	Vitamin D	76-85	MS2	Homo sapiens	16-19
20357029-6	2010	The main findings were as follow: 1) FGF23-dependent phosphaturic activity in Npt2a KO mice is dependent on renal Npt2c and PiT-2 protein; 2) in DKO mice, renal P(i) reabsorption is not further decreased by FGF23M, but renal vitamin D synthesis is suppressed; and 3) downregulation of intestinal Npt2b may be mediated by a factor(s) other than 1,25(OH)(2)D(3).	Vitamin D	225-234	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	78-83
20111885-6	2010	By contrast, vitamin D increased PAD1-3 mRNA amounts, with distinct kinetics, but neither the proteins nor the deimination rate.	Vitamin D	13-22	peptidyl arginine deiminase 1	Homo sapiens	33-37
20043299-1	2010	The activity of beta-catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon.	Vitamin D	96-105	catenin beta 1	Homo sapiens	16-28
20208539-0	2010	Vitamin D controls T cell antigen receptor signaling and activation of human T cells.	Vitamin D	0-9	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	19-42
19783860-2	2010	Vitamin D(3) is converted to 1,25(OH)D(3) by CYP2R1 and CYP27B1.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	45-51
19783860-4	2010	VDR, CYP27B1 or CYP2R1 gene variants could modify the biological activity of vitamin D(3).	Vitamin D	77-86	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	16-22
25302107-10	2010	There were significantly more covered than non-covered women with a vitamin D concentration lower than 30 ng/ml (OR6.2; 95% CI: 1,8-21,7; p &lt; 0,05).	Vitamin D	68-77	olfactory receptor family 2 subfamily H member 1	Homo sapiens	113-118
19426197-1	2009	OBJECTIVE: To determine the effectiveness of vitamin D therapy in patients with asymptomatic, prostate-specific antigen (PSA)-progression of prostate cancer.	Vitamin D	45-54	kallikrein related peptidase 3	Homo sapiens	94-125
19426197-3	2009	Vitamin D therapy was discontinued on disease progression as assessed by symptoms or serum PSA increase.	Vitamin D	0-9	kallikrein related peptidase 3	Homo sapiens	91-94
19426197-4	2009	The response to therapy was judged from changes in PSA level from the pretreatment baseline to 3 months after starting vitamin D therapy.	Vitamin D	119-128	kallikrein related peptidase 3	Homo sapiens	51-54
19426197-5	2009	RESULTS: Of the 26 patients, five (20%) responded to vitamin D; the mean (range) reduction in PSA level was 45.3 (15.9-95.1)%, and mean duration of response was 4-5 months.	Vitamin D	53-62	kallikrein related peptidase 3	Homo sapiens	94-97
19861511-5	2009	There were no statistically significant changes in the expression of either MIB-1 or hTERT in the crypts overall; however, the proportion of hTERT, but not MIB-1, expression that extended into the upper 40% of the crypts was reduced by 15% (P = 0.02) in the vitamin D plus calcium group relative to the placebo.	Vitamin D	258-267	telomerase reverse transcriptase	Homo sapiens	141-146
19615945-7	2009	Vitamin D(3) significantly reduced the MMP-7 (p=0.0001) and MMP-9 (p=0.0001) and increased the TIMP-1 (p=0.005) level in antigen stimulated and unstimulated cultures of PTB as compared to HC.	Vitamin D	0-9	matrix metallopeptidase 7	Homo sapiens	39-44
20021806-0	2009	[Effect of vitamin D supplementation in early life on the expression of interleukin-10 and intercellular adhesion molecule-1 in rat asthma model].	Vitamin D	11-20	interleukin 10	Rattus norvegicus	72-86
19667162-3	2009	There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the hepatic microsomal or mitochondrial vitamin D-25-hydroxylase (CYP27A1) and the renal mitochondrial 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) for vitamin D and 25(OH)D3 (calcidiol), respectively.	Vitamin D	90-99	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	141-165
19667162-3	2009	There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the hepatic microsomal or mitochondrial vitamin D-25-hydroxylase (CYP27A1) and the renal mitochondrial 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) for vitamin D and 25(OH)D3 (calcidiol), respectively.	Vitamin D	90-99	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	167-174
19667162-3	2009	There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the hepatic microsomal or mitochondrial vitamin D-25-hydroxylase (CYP27A1) and the renal mitochondrial 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) for vitamin D and 25(OH)D3 (calcidiol), respectively.	Vitamin D	141-150	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	167-174
19414758-10	2009	The in vivo expansion of Ag-specific Treg with the topical application of the vitamin D analog calcipotriol followed by transcutaneous immunization is a simple method to augment functional Ag-specific CD4(+)CD25(+)Foxp3(+) Treg populations and mimics Ag-specific UV-induced tolerance.	Vitamin D	78-87	forkhead box P3	Mus musculus	214-219
19056816-0	2009	Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells.	Vitamin D	19-28	anti-Mullerian hormone	Homo sapiens	79-109
19056816-0	2009	Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells.	Vitamin D	19-28	anti-Mullerian hormone	Homo sapiens	111-114
19056816-0	2009	Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells.	Vitamin D	19-28	anti-Mullerian hormone	Homo sapiens	140-143
19056816-4	2009	We identified a 15-bp sequence, GGGTGAgcaGGGACA, in the MIS promoter that was highly similar to direct repeat 3-type vitamin D response elements (VDREs).	Vitamin D	117-126	anti-Mullerian hormone	Homo sapiens	56-59
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	12-21	toll like receptor 4	Homo sapiens	92-96
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	154-163	toll like receptor 4	Homo sapiens	92-96
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	114-123	nuclear receptor co-repressor 2	Mus musculus	153-157
18539154-6	2008	The immunoexpression of tumor suppressor p53 and downregulation of antiapoptotic protein BCl-2 in subsequent immunofluorescence assay further provide strong evidence for the combinatorial inhibitory actions of vanadium and vitamin D(3) against DMH-induced rat colon carcinogenesis.	Vitamin D	223-232	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	41-44
18711112-9	2008	The modification of past sun exposure by MC1R genotype provides further support that ultraviolet radiation or derivatives such as vitamin D may be causally related to a reduced MS risk.	Vitamin D	130-139	melanocortin 1 receptor	Homo sapiens	41-45
22561756-0	2012	Vitamin D-mediated regulation of CYP21A2 transcription - a novel mechanism for vitamin D action.	Vitamin D	0-9	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	33-40
22561756-0	2012	Vitamin D-mediated regulation of CYP21A2 transcription - a novel mechanism for vitamin D action.	Vitamin D	79-88	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	33-40
22561756-5	2012	The mechanism for the effects of vitamin D on the CYP21A2 promoter was studied using chromatin immunoprecipitation assay, mutagenesis and gene silencing by siRNA.	Vitamin D	33-42	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	50-57
22561756-8	2012	We identified a vitamin D response element in the CYP21A2 promoter.	Vitamin D	16-25	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	50-57
22561756-10	2012	When this sequence was deleted, the effect of 1alpha,25-dihydroxyvitamin D(3) was abolished, indicating that this sequence in the CYP21A2 promoter functions as a vitamin D response element.	Vitamin D	65-74	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	130-137
22561756-12	2012	GENERAL SIGNIFICANCE: This paper reports data important for the understanding of the mechanisms for vitamin D-mediated suppression of gene expression as well as for the vitamin D-mediated effects on CYP21A2.	Vitamin D	169-178	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	199-206
22964475-7	2012	In the calcium/vitamin D(3)-supplemented group, beta-catenin decreased 11% (P = 0.20), E-cadherin increased 51% (P = 0.08), and the APC/beta-catenin score increased 16% (P = 0.26).	Vitamin D	15-24	catenin beta 1	Homo sapiens	136-148
22964475-8	2012	These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	43-52	catenin beta 1	Homo sapiens	65-77
22964475-8	2012	These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	43-52	catenin beta 1	Homo sapiens	308-320
22964475-8	2012	These results support (i) that calcium and vitamin D modify APC, beta-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms, (ii) calcium and vitamin D as potential chemopreventive agents against colorectal neoplasms, and (iii) the potential of APC, beta-catenin, and E-cadherin expression as modifiable, preneoplastic risk biomarkers for colorectal neoplasms.	Vitamin D	200-209	catenin beta 1	Homo sapiens	308-320
22801788-3	2012	Vitamin D also exerts protective effects against SLE through non-genomic factors, such as ultraviolet radiation (UV) exposure, matrix metalloproteinase (MMPs), heme oxygenase-1 (HO-1), the prostaglandins (PGs), cyclooxygenase-2 (COX-2), and oxidative stress.	Vitamin D	0-9	heme oxygenase 1	Homo sapiens	160-176
22800603-5	2012	In HCs, vitamin D(3) significantly suppressed the MCP-1 mRNA expression of CFA stimulated cells (p=0.0027), while no such effect was observed in PTB patients.	Vitamin D	8-17	C-C motif chemokine ligand 2	Homo sapiens	50-55
22476084-5	2012	As further support that this novel interactor might be involved in vitamin D-stimulated transcriptional regulation, we demonstrate that VDR and DDX5 co-localize within the nuclei of HaCaT keratinocytes and sub-cellular protein fractions.	Vitamin D	67-76	DEAD-box helicase 5	Homo sapiens	144-148
23063903-1	2012	CYP2R1 (25alpha-hydroxylase) catalyzes vitamin D(3) to 25-hydroxyvitamin D(3), while the CYP27B1 (1alpha-hydroxylase) catalyzes the 25(OH)D(3) to 1, 25(OH)(2)D(3).	Vitamin D	39-48	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
22508713-13	2012	CONCLUSION: Vitamin D may be a positive regulator of AMH production in adults, and vitamin D deficiency may confound clinical decisions based on AMH.	Vitamin D	83-92	anti-Mullerian hormone	Homo sapiens	145-148
22508713-14	2012	Vitamin D deficiency should be considered when serum AMH levels are obtained for diagnosis.	Vitamin D	0-9	anti-Mullerian hormone	Homo sapiens	53-56
18534255-1	2008	Vitamin D (VD), is a steroid hormone with multiple functions in the central nervous system (CNS), producing numerous physiological effects mediated by its receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	165-168
18649741-1	2008	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D (1alpha,25(OH)2D), inhibits proliferation and induces the differentiation of prostate cells in culture, attenuates tumor growth in animal models, and decreases prostate specific antigen (PSA) levels in prostate cancer patients.	Vitamin D	19-28	kallikrein related peptidase 3	Homo sapiens	219-250
18511070-2	2008	CYP2R1 catalyzes the initial step converting vitamin D into 25-hydroxyvitamin D.	Vitamin D	45-54	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
18212051-10	2008	The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene.	Vitamin D	41-50	insulin-like growth factor binding protein 3	Mus musculus	4-11
18212051-10	2008	The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene.	Vitamin D	41-50	insulin-like growth factor binding protein 3	Mus musculus	178-185
17911404-10	2007	This defines a novel function of FGF23 in addition to the previously established roles in controlling vitamin D and Pi metabolism.	Vitamin D	102-111	fibroblast growth factor 23	Bos taurus	33-38
17855664-8	2007	Targeted down-regulation of NCoR1 and SMRT by small interference RNA was able to restore CWR22R-2 response to vitamin D.	Vitamin D	110-119	nuclear receptor corepressor 1	Homo sapiens	28-33
17855664-9	2007	Together, we showed that increased NCoR1 and SMRT expression in CWR22R-2 cells resulted in reduced VDR-mediated transcriptional activity and attenuated antiproliferative response to vitamin D.	Vitamin D	182-191	nuclear receptor corepressor 1	Homo sapiens	35-40
17933711-9	2007	Furthermore, fecal elastase 1 of patients correlated the same way with both D-vitamins (p &lt;0.01).	Vitamin D	76-86	chymotrypsin like elastase 3B	Homo sapiens	13-29
17130524-7	2007	In addition, nuclear receptor cofactors NCoR1 and SRC1 that could potentially affect VDR action were also low in both MDA-MB231 and S30 cells in comparison with ER-positive, vitamin D-sensitive BT474 cells.	Vitamin D	174-183	nuclear receptor corepressor 1	Homo sapiens	40-45
17292862-1	2007	CYP27A1 catalyzes vitamin D(3) 25-hydroxylation and further hydroxylation at C-1alpha, C-24 or C-26(27).	Vitamin D	18-27	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
17267207-4	2007	The renal levels of 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) mRNA were highest in animal groups fed on vitamin D between 0 and 300 ng/day.	Vitamin D	30-39	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	60-67
16927309-7	2007	Interestingly, TGFbeta and Vitamin D-mediated transcription of osteoblast genes (except for osteopontin) required the presence of Runx2.	Vitamin D	27-36	runt related transcription factor 2	Mus musculus	130-135
17392597-8	2007	Collectively, these results indicate that vitamin D analogs modulate CK in skeletal tissues and up-regulate its response and sensitivity to E2 and to SERM in these tissues, possibly via an increase in ERalpha protein.	Vitamin D	42-51	estrogen receptor 1	Rattus norvegicus	201-208
22594500-10	2012	The change in expression of miR-221 from baseline to 12 months (ddCp value) was also significantly different between the vitamin D and placebo group (P =0.04), mainly due to a change in the placebo group.	Vitamin D	121-130	microRNA 221	Homo sapiens	28-35
17071612-4	2006	Here we describe the purification, molecular cloning, and expression of this vitamin D resistance-causing, competitive response element-binding protein (REBiP) hnRNP C1/C2.	Vitamin D	77-86	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	160-171
22547651-4	2012	Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs.	Vitamin D	0-9	thrombomodulin	Homo sapiens	94-99
17071612-7	2006	Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2.	Vitamin D	101-110	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	391-402
17148678-5	2006	In addition, loss of vitamin D activities from Fgf-23-/- mice reverses the severe hyperphosphatemia to hypophosphatemia, attributable to increased urinary phosphate wasting in Fgf-23-/-/1alpha(OH)ase-/- mice, possibly as a consequence of decreased expression of NaPi2a.	Vitamin D	21-30	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	262-268
22210453-5	2012	We also examined the ability of CYP27A1 to metabolize 20-hydroxyvitamin D3 (20(OH)D3), a novel non-calcemic form of vitamin D derived from CYP11A1 action on vitamin D3 which has anti-proliferative activity on keratinocytes, leukemic and myeloid cells.	Vitamin D	64-73	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	32-39
17056528-6	2006	We report that vitamin D(3) and 1,25-(OH)(2)D(3) strongly inhibited myelin oligodendrocyte peptide (MOG(35-55))-induced EAE in C57BL/6 mice, but completely failed to inhibit EAE in mice with a disrupted IL-10 or IL-10R gene.	Vitamin D	15-24	myelin oligodendrocyte glycoprotein	Mus musculus	100-103
22065093-1	2012	OBJECTIVES: To identify relationships between vitamin D serum levels and the presence of autoantibodies directed against vitamin D and levels of interleukin(IL)-17 and IL-23 in patients with systemic lupus erythematosus (SLE).	Vitamin D	46-55	interleukin 23 subunit alpha	Homo sapiens	168-173
22065093-14	2012	However, serum concentrations of IL-23 were lower in patients with vitamin D deficiency (p = 0.037).	Vitamin D	67-76	interleukin 23 subunit alpha	Homo sapiens	33-38
17056528-6	2006	We report that vitamin D(3) and 1,25-(OH)(2)D(3) strongly inhibited myelin oligodendrocyte peptide (MOG(35-55))-induced EAE in C57BL/6 mice, but completely failed to inhibit EAE in mice with a disrupted IL-10 or IL-10R gene.	Vitamin D	15-24	interleukin 10 receptor, alpha	Mus musculus	212-218
17056528-11	2006	In this way, a genetic IL-10-IL-10R pathway defect could interact with an environmental risk factor, vitamin D(3) insufficiency, to increase MS risk and severity.	Vitamin D	101-110	interleukin 10 receptor, alpha	Mus musculus	29-35
17029789-12	2006	Collectively, these results indicate that Vitamin D analogs modulate cell energy homeostasis in vascular tissues through induction of CK and up regulation of the response and sensitivity of CK in vascular tissues to E2 and to SERMs, possibly through via an increase in ERalpha protein in female derived organs.	Vitamin D	42-51	estrogen receptor 1	Rattus norvegicus	269-276
21801466-0	2012	Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells.	Vitamin D	38-47	phosphatase and tensin homolog	Homo sapiens	147-179
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	thrombomodulin	Homo sapiens	271-275
22213318-2	2012	Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys.	Vitamin D	62-71	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	109-133
22143249-6	2012	The mechanism underlying the renal and cardiovascular protection involves regulation of multiple signaling pathways by vitamin D including nuclear factor kappaB, Wnt/beta-catenin and the renin-angiotensin system.	Vitamin D	119-128	catenin beta 1	Homo sapiens	166-178
16842832-8	2006	Interestingly, human CYP2J2 hydroxylated vitamin D2, an exogenous vitamin D, at a higher rate than it did vitamin D3, an endogenous vitamin D, whereas, rat CYP2J3 hydroxylated vitamin D3 (1.4 min(-1)) more efficiently than vitamin D2 (0.86 min(-1)).	Vitamin D	41-50	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	156-162
22028071-10	2012	Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 beta.	Vitamin D	14-23	C-C motif chemokine ligand 2	Homo sapiens	158-163
22028071-10	2012	Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 beta.	Vitamin D	14-23	C-C motif chemokine ligand 4	Homo sapiens	169-179
16842832-8	2006	Interestingly, human CYP2J2 hydroxylated vitamin D2, an exogenous vitamin D, at a higher rate than it did vitamin D3, an endogenous vitamin D, whereas, rat CYP2J3 hydroxylated vitamin D3 (1.4 min(-1)) more efficiently than vitamin D2 (0.86 min(-1)).	Vitamin D	66-75	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	156-162
22866178-8	2012	However, vitamin D supplementation markedly enhanced TLR2/1L-induced responses in MDMs e.g. IL-6, IL-12 and IL-23 among Caucasians but not in the Dene participants.	Vitamin D	9-18	interleukin 23 subunit alpha	Homo sapiens	108-113
16741990-0	2006	Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth.	Vitamin D	74-83	peptide deformylase, mitochondrial	Homo sapiens	0-23
16918822-1	2006	INTRODUCTION: Vitamin D is essential for calcium metabolism as well as for fracture prevention, and a recent review suggested that the optimal serum 25(OH)D lies in the region of 50-80 nmol L-1 (20-32 ng mL-1).	Vitamin D	14-23	L1 cell adhesion molecule	Mus musculus	190-193
23896933-0	2011	19F NMR study on the complex of fluorinated vitamin D derivatives with vitamin D receptor: elucidation of the conformation of vitamin D ligands accommodated in the receptor.	Vitamin D	44-53	vitamin D receptor	Rattus norvegicus	71-89
23896933-2	2011	The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD.	Vitamin D	19-28	vitamin D receptor	Rattus norvegicus	34-52
23896933-2	2011	The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD.	Vitamin D	19-28	vitamin D receptor	Rattus norvegicus	54-57
23896933-2	2011	The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD.	Vitamin D	19-28	vitamin D receptor	Rattus norvegicus	187-190
23896933-2	2011	The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD.	Vitamin D	34-43	vitamin D receptor	Rattus norvegicus	54-57
16889531-4	2006	Interestingly, vitamin D and RA demonstrated a consistent, dose-dependent enhancement of osteogenesis and upregulated osteoblast specific markers including osteopontin and osteocalcin.	Vitamin D	15-24	bone gamma-carboxyglutamate protein 2	Mus musculus	172-183
23896933-6	2011	The fluorinated vitamin D derivatives showed marked changes in the chemical shift (Delta4-19.7 ppm) upon VDR-complex formation, and the ab initio MO method suggested that van der Waals interactions play a major role in the complex formation.	Vitamin D	16-25	vitamin D receptor	Rattus norvegicus	105-108
16533909-0	2006	A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells.	Vitamin D	8-17	bone morphogenetic protein 1	Homo sapiens	39-65
16500955-1	2006	Human CYP27A1 is a mitochondrial cytochrome P450, which is principally found in the liver and plays important roles in the biological activation of vitamin D(3) and in the biosynthesis of bile acids.	Vitamin D	148-157	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	6-13
21908411-11	2011	CONCLUSIONS: Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function.	Vitamin D	19-28	H19 imprinted maternally expressed transcript	Homo sapiens	89-92
16521124-1	2006	The vitamin D receptor (VDR) is believed to mediate different biologic actions of vitamin D3, an active metabolite of vitamin D, through regulation of gene expression after binding to specific DNA-response element (VDRE) on target genes.	Vitamin D	4-13	vitamin D receptor	Rattus norvegicus	24-27
21898591-9	2011	Chromatin immunoprecipitation on chip and transfection studies revealed a functional vitamin D response element in the second intron of cbs.	Vitamin D	85-94	cystathionine beta-synthase	Mus musculus	136-139
22040820-3	2011	Such vitamin D action for bone tissue is recapitulated in intact animals, while vitamin D is well known to potentiate bone resorption by inducing gene of RANKL an osteoclastic inducer.	Vitamin D	5-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	154-159
22040820-3	2011	Such vitamin D action for bone tissue is recapitulated in intact animals, while vitamin D is well known to potentiate bone resorption by inducing gene of RANKL an osteoclastic inducer.	Vitamin D	80-89	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	154-159
21613813-9	2011	We observed a significant decrease of fasting and stimulated glucose (V3, p&lt;0.05) and C-peptide levels (V2 and 3, p&lt;0.001) after vitamin D treatment.	Vitamin D	135-144	T cell receptor gamma variable 9	Homo sapiens	89-115
21653679-4	2011	Interestingly, one of the most highly upregulated genes by vitamin D(3) was the proinflammatory cytokine interleukin-1alpha (IL-1alpha).	Vitamin D	59-68	interleukin 1 alpha	Homo sapiens	105-123
21653679-4	2011	Interestingly, one of the most highly upregulated genes by vitamin D(3) was the proinflammatory cytokine interleukin-1alpha (IL-1alpha).	Vitamin D	59-68	interleukin 1 alpha	Homo sapiens	125-134
21653679-5	2011	Systems biology analyses supported a central role for IL-1alpha in the vitamin D(3) response in PrP/SCs.	Vitamin D	71-80	interleukin 1 alpha	Homo sapiens	54-63
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	48-57	interleukin 1 alpha	Homo sapiens	28-37
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	166-175	interleukin 1 alpha	Homo sapiens	28-37
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	166-175	interleukin 1 alpha	Homo sapiens	120-129
21653679-7	2011	These studies establish a system to study the molecular profile of PrP/SC differentiation, proliferation, and senescence, and they point to an important new role for IL-1alpha in vitamin D(3) signaling in PrP/SCs.	Vitamin D	179-188	interleukin 1 alpha	Homo sapiens	166-175
21762639-10	2011	CONCLUSIONS: Abnormalities in phosphate and vitamin D metabolism were associated with increased hepcidin levels independently of eGFR in CKD patients.	Vitamin D	44-53	hepcidin antimicrobial peptide	Homo sapiens	96-104
21656831-10	2011	Upon multiple adjusted linear regression analysis, prostate size correlated with BMI and serum PSA (both P &lt; 0.001), and serum PSA levels correlated with BMI and prostate size (P = 0.007, P &lt; 0.001, respectively), but neither variable correlated with PTH, vitamin D, or serum calcium levels.	Vitamin D	262-271	aminopeptidase puromycin sensitive	Homo sapiens	130-133
21472188-0	2011	Synthesis of C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation, especially biological effect on bone by modification at the C-2 position.	Vitamin D	29-38	complement C2	Homo sapiens	13-16
21472188-0	2011	Synthesis of C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation, especially biological effect on bone by modification at the C-2 position.	Vitamin D	29-38	complement C2	Homo sapiens	170-173
21472188-1	2011	In order to obtain vitamin D derivatives, which have strong activity for enhancing bone growth, we designed vitamin D derivatives with various substitutions at the C-2 position.	Vitamin D	19-28	complement C2	Homo sapiens	164-167
21472188-1	2011	In order to obtain vitamin D derivatives, which have strong activity for enhancing bone growth, we designed vitamin D derivatives with various substitutions at the C-2 position.	Vitamin D	108-117	complement C2	Homo sapiens	164-167
20655720-11	2011	In conclusion, vitamin D(3) shows a potential therapeutic effect in normalizing diabetes-induced alterations in cholinergic, insulin and vitamin D receptor and maintains a normal glucose transport and utilisation in the cortex.	Vitamin D	15-24	vitamin D receptor	Rattus norvegicus	137-155
16517748-10	2006	Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes.	Vitamin D	41-50	interleukin 1 receptor antagonist	Homo sapiens	131-137
16517748-10	2006	Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes.	Vitamin D	41-50	interleukin 1 alpha	Homo sapiens	141-150
16582618-3	2006	A recent study from our laboratory showed that expression of the gene encoding p19(INK4D) is induced by the hormonal form of vitamin D(3) and by retinoids, both of which signal through related nuclear receptor transcription factors.	Vitamin D	125-134	cyclin dependent kinase inhibitor 2D	Homo sapiens	79-82
16582618-3	2006	A recent study from our laboratory showed that expression of the gene encoding p19(INK4D) is induced by the hormonal form of vitamin D(3) and by retinoids, both of which signal through related nuclear receptor transcription factors.	Vitamin D	125-134	cyclin dependent kinase inhibitor 2D	Homo sapiens	83-88
16371465-6	2006	Upon administration of a diet low in calcium and devoid of any form of vitamin D(3), beta-galactosidase activity was detected in the kidneys of the -/- and +/- mice and in placentas harvested from -/- females bred with -/- males.	Vitamin D	71-80	galactosidase, beta 1	Mus musculus	85-103
16242929-5	2006	Osteocalcin was also up-regulated in a dose-dependent manner, suggesting that the three Vitamin D analogs have the equal potencies on bone formation.	Vitamin D	88-97	bone gamma-carboxyglutamate protein 2	Mus musculus	0-11
17237623-6	2006	The vitamin D analogs modulated cell cycle regulators, including decreasing mRNA and protein levels of p21(Waf1/Cip1) (p21) and cyclin-dependent kinase 2 (cdk2), and increasing p27(Kip1) (p27) protein expression.	Vitamin D	4-13	cyclin dependent kinase inhibitor 1B	Homo sapiens	177-186
17237623-6	2006	The vitamin D analogs modulated cell cycle regulators, including decreasing mRNA and protein levels of p21(Waf1/Cip1) (p21) and cyclin-dependent kinase 2 (cdk2), and increasing p27(Kip1) (p27) protein expression.	Vitamin D	4-13	interferon alpha inducible protein 27	Homo sapiens	177-180
16371233-0	2006	Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells.	Vitamin D	11-20	serpin family E member 1	Homo sapiens	50-83
16371233-10	2006	CONCLUSION: These results demonstrate that vitamin D analogs suppress PAI-1 in SMC, but not in CAEC.	Vitamin D	43-52	serpin family E member 1	Homo sapiens	70-75
16371233-11	2006	Suppression of PAI-1 in SMC may be one of the factors contributing to the survival benefits of vitamin D analog therapy in CKD patients.	Vitamin D	95-104	serpin family E member 1	Homo sapiens	15-20
16239345-11	2005	We conclude that vitamin D-regulated relB transcription in DCs is controlled by chromatin remodeling by means of recruitment of complexes including HDAC3.	Vitamin D	17-26	histone deacetylase 3	Mus musculus	148-153
16189633-1	2005	BACKGROUND: 1,25-dihydroxy-22-ovavitamin D(3) (22-oxacalcitriol, OCT) was recently introduced commercially as an analogue of 1,25 (OH)(2) vitamin D(3), but one which has less pronounced calcemic activity.	Vitamin D	33-42	plexin A2	Homo sapiens	65-68
15836435-9	2005	The vitamin D stimulatory element, a target for the JNK module, and an Ets-1 binding site were shown to be vital for synergy between PMA and 1,25D.	Vitamin D	4-13	mitogen-activated protein kinase 8	Rattus norvegicus	52-55
15878768-1	2005	BACKGROUND: Vitamin D might have an influence on glucose concentrations, due to the presence of VDR receptors on the pancreas.	Vitamin D	12-21	vitamin D receptor	Rattus norvegicus	96-99
15749627-0	2005	Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse after definitive therapy.	Vitamin D	31-40	kallikrein related peptidase 3	Homo sapiens	76-79
21598808-0	2011	Increased vitamin D serum levels correlate with clinical improvement of rheumatic diseases after Dead Sea climatotherapy.	Vitamin D	10-19	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
21598808-10	2011	CONCLUSIONS: Climatotherapy at the Dead Sea induces significant changes in vitamin D.	Vitamin D	75-84	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	40-43
21176770-10	2011	In mice LPS stimulated PAI-1 expression in the heart and macrophages, and the stimulation was blunted by pre-treatment with a vitamin D analog.	Vitamin D	126-135	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	23-28
21176770-12	2011	Inhibition of PAI-1 production may contribute to the reno- and cardio-protective effects of vitamin D.	Vitamin D	92-101	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	14-19
20980705-0	2011	Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression.	Vitamin D	0-9	coagulation factor III, tissue factor	Homo sapiens	85-98
20980705-7	2011	The effect of vitamin D (1,25-dihydroxyvitamin D, 10 nm) on anti-beta2GPI-Abs mediated TF expression was analysed by immunoblot.	Vitamin D	14-23	apolipoprotein H	Homo sapiens	65-73
20980705-7	2011	The effect of vitamin D (1,25-dihydroxyvitamin D, 10 nm) on anti-beta2GPI-Abs mediated TF expression was analysed by immunoblot.	Vitamin D	14-23	coagulation factor III, tissue factor	Homo sapiens	87-89
20980705-9	2011	In vitro vitamin D inhibited the expression of TF induced by anti-beta2GPI-antibodies.	Vitamin D	9-18	coagulation factor III, tissue factor	Homo sapiens	47-49
20980705-9	2011	In vitro vitamin D inhibited the expression of TF induced by anti-beta2GPI-antibodies.	Vitamin D	9-18	apolipoprotein H	Homo sapiens	66-74
20980705-11	2011	Vitamin D inhibits anti-beta2GPI-mediated TF expression in vitro.	Vitamin D	0-9	apolipoprotein H	Homo sapiens	24-32
20980705-11	2011	Vitamin D inhibits anti-beta2GPI-mediated TF expression in vitro.	Vitamin D	0-9	coagulation factor III, tissue factor	Homo sapiens	42-44
20980705-12	2011	Thus, vitamin D deficiency might be associated with decreased inhibition of TF expression and increased coagulation in APS.	Vitamin D	6-15	coagulation factor III, tissue factor	Homo sapiens	76-78
22135503-2	2011	Sun exposure, the natural source of vitamin D, is the main risk factor for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).	Vitamin D	36-45	serpin family B member 3	Homo sapiens	131-134
20736132-14	2011	CONCLUSION(S): Vitamin D inhibits growth of HuLM cells through the down-regulation of PCNA, CDK1, and BCL-2 and suppresses COMT expression and activity in HuLM cells.	Vitamin D	15-24	proliferating cell nuclear antigen	Homo sapiens	86-90
20736132-14	2011	CONCLUSION(S): Vitamin D inhibits growth of HuLM cells through the down-regulation of PCNA, CDK1, and BCL-2 and suppresses COMT expression and activity in HuLM cells.	Vitamin D	15-24	cyclin dependent kinase 1	Homo sapiens	92-96
22216097-7	2011	CONCLUSION: The results from this study suggest that improving vitamin D status may help lower risk of colorectal cancer associated with higher IGF-1/IGFBP-3 ratio or C-peptide levels.	Vitamin D	63-72	insulin like growth factor binding protein 3	Homo sapiens	150-157
22174918-2	2011	LRP2 knockout mice showed severe vitamin D deficiency and bone disease, indicating the involvement of LRP2 in the preservation of vitamin D metabolites and delivery of the precursor to the kidney for the generation of 1alpha,25(OH)(2)D(3).	Vitamin D	33-42	low density lipoprotein receptor-related protein 2	Mus musculus	0-4
22174918-2	2011	LRP2 knockout mice showed severe vitamin D deficiency and bone disease, indicating the involvement of LRP2 in the preservation of vitamin D metabolites and delivery of the precursor to the kidney for the generation of 1alpha,25(OH)(2)D(3).	Vitamin D	130-139	low density lipoprotein receptor-related protein 2	Mus musculus	0-4
22174918-2	2011	LRP2 knockout mice showed severe vitamin D deficiency and bone disease, indicating the involvement of LRP2 in the preservation of vitamin D metabolites and delivery of the precursor to the kidney for the generation of 1alpha,25(OH)(2)D(3).	Vitamin D	130-139	low density lipoprotein receptor-related protein 2	Mus musculus	102-106
20974859-0	2010	Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression.	Vitamin D	0-9	DNA-damage inducible transcript 3	Mus musculus	58-82
20974859-0	2010	Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression.	Vitamin D	0-9	DNA-damage inducible transcript 3	Mus musculus	84-88
15749627-3	2005	We investigated the effect of the nutrient vitamin D (cholecalciferol), a biochemical precursor of calcitriol, on PSA levels and the rate of rise of PSA in these patients.	Vitamin D	43-52	kallikrein related peptidase 3	Homo sapiens	114-117
15659788-12	2004	VD/VD-R binds to the vitamin D-responsive element (VDRE) on the target genes.	Vitamin D	21-30	vitamin D receptor	Rattus norvegicus	3-7
15663994-7	2004	Androgens, retinoids, glucocorticoids, estrogens and agonists of PPAR directly or indirectly impact Vitamin D signaling pathways, and vice versa.	Vitamin D	100-109	peroxisome proliferator activated receptor alpha	Homo sapiens	65-69
20820764-9	2010	hOBs from young individuals responded to stimulation with vitamin D with a more pronounced increase in alkaline phosphatase: 107 +- 17% vs. 43 +- 5%, P &lt; 0.01.	Vitamin D	58-67	leptin	Homo sapiens	0-4
20711952-8	2010	Vitamin D stimulates ovarian steroidogenesis and IGFBP-1 production in human ovarian cells likely acting via vitamin D receptor.	Vitamin D	0-9	insulin like growth factor binding protein 1	Homo sapiens	49-56
20711952-10	2010	Vitamin D also enhances inhibitory effect of insulin on IGFBP-1 production.	Vitamin D	0-9	insulin like growth factor binding protein 1	Homo sapiens	56-63
15377346-8	2004	Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression.	Vitamin D	27-36	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	228-233
15207741-0	2004	Vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways.	Vitamin D	0-9	Fas ligand	Homo sapiens	19-29
20493879-4	2010	In silico screening of the MYC gene locus identified six putative binding sites [vitamin D response elements (VDREs)] for the vitamin D receptor (VDR).	Vitamin D	81-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-30
20214986-0	2010	Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer.	Vitamin D	11-20	toll like receptor 4	Homo sapiens	41-45
20214986-9	2010	We present several signaling pathways commonly regulated by vitamin D compounds and highlight their regulation on TLR4.	Vitamin D	60-69	toll like receptor 4	Homo sapiens	114-118
20030662-0	2010	Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood.	Vitamin D	9-18	leukocyte immunoglobulin like receptor B4	Homo sapiens	72-76
20030662-4	2010	OBJECTIVE: To evaluate the association between prenatal vitamin D supplementation and tolerogenic antigen-presenting cells in cord blood (CB) as determined by mRNA measurement of immunoglobulin-like transcripts (ILT)3 and ILT4.	Vitamin D	56-65	leukocyte immunoglobulin like receptor B4	Homo sapiens	179-217
14963110-0	2004	Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.	Vitamin D	31-40	insulin like growth factor binding protein 3	Homo sapiens	71-115
20030662-9	2010	RESULTS: Maternal vitamin D supplementation during pregnancy was associated with an increase in the gene expression of ILT3 (P=0.012) and ILT4 (P&lt;0.001).	Vitamin D	18-27	leukocyte immunoglobulin like receptor B4	Homo sapiens	119-123
20030662-11	2010	CONCLUSIONS: Vitamin D supplementation during pregnancy may increase the mRNA levels of ILT3 and ILT4 in CB.	Vitamin D	13-22	leukocyte immunoglobulin like receptor B4	Homo sapiens	88-92
19857615-0	2010	Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis.	Vitamin D	125-134	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	143-148
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	serum/glucocorticoid regulated kinase 1	Mus musculus	111-114
19621386-0	2010	Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU.	Vitamin D	0-9	thymidylate synthetase	Homo sapiens	169-189
14963110-3	2004	The purpose of this study was to determine the molecular mechanism involved in 1,25-(OH)2D3 regulation of IGFBP-3 expression and to identify the putative vitamin D response element (VDRE) in the IGFBP-3 promoter.	Vitamin D	154-163	insulin like growth factor binding protein 3	Homo sapiens	195-202
20871847-10	2010	In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P &lt; .0001), IFN-gamma (-38.9%, P &lt; .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P &lt; .0001), and IL-10 (-70.4%, P &lt; .0001).	Vitamin D	14-23	colony stimulating factor 2	Homo sapiens	90-96
15086558-6	2004	A 3-17-fold upregulation of IFI27 mRNA expression was observed when keratinocytes were stimulated with IFN-gamma, TNF-alpha, or TGF-beta1 while retinoids and vitamin D downregulated its expression.	Vitamin D	158-167	interferon alpha inducible protein 27	Homo sapiens	28-33
20097959-6	2009	We show that the activity type I 5"-deiodinase was significantly decreased in livers of animals treated with vitamin D.	Vitamin D	109-118	iodothyronine deiodinase 1	Rattus norvegicus	26-46
14705237-1	2004	OBJECTIVE: The homologous upregulation produced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on vitamin D receptor (VDR) levels, and the effects produced by the heterologous agents hydrocortisone or deflazacort, alone or in conjunction with this vitamin D metabolite, were studied in rat osteoblastic UMR-106 osteosarcoma cells.	Vitamin D	65-74	vitamin D receptor	Rattus norvegicus	93-111
19924301-0	2009	Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines.	Vitamin D	39-48	transcription factor 4	Mus musculus	11-16
19419316-1	2009	X-linked hypophosphatemia (XLH), characterized by renal phosphate wasting, is the most common cause of vitamin D-resistant rickets.	Vitamin D	103-112	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	27-30
14705237-1	2004	OBJECTIVE: The homologous upregulation produced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on vitamin D receptor (VDR) levels, and the effects produced by the heterologous agents hydrocortisone or deflazacort, alone or in conjunction with this vitamin D metabolite, were studied in rat osteoblastic UMR-106 osteosarcoma cells.	Vitamin D	65-74	vitamin D receptor	Rattus norvegicus	113-116
12972427-1	2003	The signaling/oncogenic activity of beta-catenin can be repressed by the activation of nuclear receptors such as the vitamin A, vitamin D, and androgen receptors.	Vitamin D	128-137	catenin beta 1	Homo sapiens	36-48
19666701-5	2009	PCFT mRNA levels are increased in Caco-2 cells treated with 1,25-dihydroxyvitamin D(3) (vitamin D(3)) in a dose-dependent fashion, and the duodenal rat Pcft mRNA expression is induced by vitamin D(3) ex vivo.	Vitamin D	74-83	solute carrier family 46 member 1	Homo sapiens	0-4
19666701-5	2009	PCFT mRNA levels are increased in Caco-2 cells treated with 1,25-dihydroxyvitamin D(3) (vitamin D(3)) in a dose-dependent fashion, and the duodenal rat Pcft mRNA expression is induced by vitamin D(3) ex vivo.	Vitamin D	88-97	solute carrier family 46 member 1	Homo sapiens	0-4
19666701-5	2009	PCFT mRNA levels are increased in Caco-2 cells treated with 1,25-dihydroxyvitamin D(3) (vitamin D(3)) in a dose-dependent fashion, and the duodenal rat Pcft mRNA expression is induced by vitamin D(3) ex vivo.	Vitamin D	88-97	solute carrier family 46 member 1	Homo sapiens	152-156
19666701-6	2009	The PCFT promoter region is transactivated by the vitamin D receptor (VDR) and its heterodimeric partner retinoid X receptor-alpha (RXRalpha) in the presence of vitamin D(3).	Vitamin D	50-59	solute carrier family 46 member 1	Homo sapiens	4-8
12954644-0	2003	Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.	Vitamin D	0-9	cyclin dependent kinase inhibitor 1B	Homo sapiens	78-85
19666701-9	2009	Mutational promoter analyses confirmed that the PCFT(-1694/-1680) motif mediates a transcriptional response to vitamin D(3).	Vitamin D	111-120	solute carrier family 46 member 1	Homo sapiens	48-52
19666701-11	2009	In conclusion, vitamin D(3) and VDR increase intestinal PCFT expression, resulting in enhanced cellular folate uptake.	Vitamin D	15-24	solute carrier family 46 member 1	Homo sapiens	56-60
12796488-3	2003	2MD stimulates the expression of several vitamin D-sensitive genes including 25-hydroxyvitamin D3-24 hydroxylase (Cyp24), osteopontin and receptor activator of NF kappa B ligand and suppresses osteoprotegerin at concentrations two logs lower than that for 1,25(OH)2D3.	Vitamin D	41-50	secreted phosphoprotein 1	Homo sapiens	122-133
19667156-3	2009	First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 (calcitriol) on the expression of COX-2 and 15-PGDH.	Vitamin D	47-56	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	164-171
19382910-6	2009	In silico promoter analysis revealed conserved binding sites for vitamin D(3) receptor, suggesting a strong vitamin D(3) dependency of the PEA-15 promoter.	Vitamin D	65-74	proliferation and apoptosis adaptor protein 15	Homo sapiens	139-145
12716897-3	2003	Here we define the role of the Ski/N-CoR interaction in Ski-mediated repression of TGF-beta and vitamin D signaling.	Vitamin D	96-105	SKI proto-oncogene	Homo sapiens	31-34
19382910-7	2009	PEA-15 up-regulation by vitamin D(3) could be confirmed by Western blot in two different cell lines.	Vitamin D	24-33	proliferation and apoptosis adaptor protein 15	Homo sapiens	0-6
19382910-9	2009	In a functional test of this novel pathway, we demonstrated that vitamin D(3) was able to rescue cells from TRAIL-induced apoptosis through regulation of the PEA-15 expression and function.	Vitamin D	65-74	proliferation and apoptosis adaptor protein 15	Homo sapiens	158-164
18797846-5	2009	Besides, decreased expression levels of cyp2r1 and cyp27b1 (-26 and -39%, respectively, P &lt; 0.01) were measured in liver and kidney suggesting a physiological adaptation in response to the rise in vitamin D level.	Vitamin D	200-209	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	51-58
12716897-3	2003	Here we define the role of the Ski/N-CoR interaction in Ski-mediated repression of TGF-beta and vitamin D signaling.	Vitamin D	96-105	nuclear receptor corepressor 1	Homo sapiens	35-40
12716897-3	2003	Here we define the role of the Ski/N-CoR interaction in Ski-mediated repression of TGF-beta and vitamin D signaling.	Vitamin D	96-105	SKI proto-oncogene	Homo sapiens	56-59
19444937-15	2009	Accumulation of damage on DNA and telomeres cause both aging and cancer, moreover the signalling pathways seem to converge on tumour suppressor protein, p53, which seems to be regulated by vitamin D.	Vitamin D	189-198	transformation related protein 53, pseudogene	Mus musculus	153-156
12716897-4	2003	We show that Ski can negatively regulate vitamin D-mediated transcription by directly interacting with the vitamin D receptor.	Vitamin D	41-50	SKI proto-oncogene	Homo sapiens	13-16
19444937-18	2009	Also NF-kappaB and telomerase reverse transcriptase (TERT) might be molecular mechanisms mediating vitamin D action in aging and cancer.	Vitamin D	99-108	telomerase reverse transcriptase	Mus musculus	19-51
12716897-5	2003	More importantly, a Ski single point mutant lacking N-CoR binding revealed that the Ski/N-CoR interaction is essential for repression of vitamin D signaling, but, surprisingly, not TGF-beta signaling.	Vitamin D	137-146	SKI proto-oncogene	Homo sapiens	20-23
19444937-18	2009	Also NF-kappaB and telomerase reverse transcriptase (TERT) might be molecular mechanisms mediating vitamin D action in aging and cancer.	Vitamin D	99-108	telomerase reverse transcriptase	Mus musculus	53-57
18683889-3	2009	However, involvement of BMP signaling in vitamin D(3)-mediated osteoinduction has not been reported.	Vitamin D	41-50	bone morphogenetic protein 1	Homo sapiens	24-27
18683889-9	2009	Taken together, these results suggest that BMP signaling plays a role in the induction of an osteoblastic phenotype in human dermal fibroblasts in response to vitamin D(3) stimulation.	Vitamin D	159-168	bone morphogenetic protein 1	Homo sapiens	43-46
19035286-4	2008	Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression.	Vitamin D	52-61	catenin beta 1	Homo sapiens	127-139
12716897-5	2003	More importantly, a Ski single point mutant lacking N-CoR binding revealed that the Ski/N-CoR interaction is essential for repression of vitamin D signaling, but, surprisingly, not TGF-beta signaling.	Vitamin D	137-146	SKI proto-oncogene	Homo sapiens	84-87
19035286-4	2008	Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression.	Vitamin D	52-61	catenin beta 1	Homo sapiens	214-226
12716897-5	2003	More importantly, a Ski single point mutant lacking N-CoR binding revealed that the Ski/N-CoR interaction is essential for repression of vitamin D signaling, but, surprisingly, not TGF-beta signaling.	Vitamin D	137-146	nuclear receptor corepressor 1	Homo sapiens	88-93
12759887-8	2003	If fecal elastase 1 in patients was below 200 micro g/g, then the BMD and vitamin D(3) values were also significantly decreased compared to those with fecal elastase 1 above 200 micro g/g.	Vitamin D	74-83	chymotrypsin like elastase 3B	Homo sapiens	3-19
18660672-9	2008	Further investigations on endocrine axes mediated by the Klotho family and FGF19 subfamily members are expected to provide new insights into the molecular mechanisms by which the endocrine fibroblast growth factors regulate bile acid, energy, and phosphate/vitamin D metabolism.	Vitamin D	257-266	fibroblast growth factor 15	Mus musculus	75-80
12480707-6	2003	Moreover, siRNA-mediated AML1/MTG8 suppression results in changes in cell shape and, in combination with TGF beta(1)/vitamin D(3), severely reduces clonogenicity of Kasumi-1 cells.	Vitamin D	117-126	RUNX family transcription factor 1	Homo sapiens	25-29
18502116-6	2008	Vitamin D receptor (vdr) and retinoid X receptor alpha (rxralpha), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased.	Vitamin D	135-144	vitamin D receptor	Rattus norvegicus	0-18
18502116-6	2008	Vitamin D receptor (vdr) and retinoid X receptor alpha (rxralpha), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased.	Vitamin D	135-144	vitamin D receptor	Rattus norvegicus	20-23
12670492-4	2003	Inhibition experiments indicated that tolterodine and 7 alpha-hydroxy-4-cholesten-3-one were selective inhibitors of the CYP2D25- and CYP27A-mediated 25-hydroxylation of vitamin D(3), respectively.	Vitamin D	170-179	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	121-128
18411217-8	2008	In vitro analysis showed that vitamin D(3) was found to dose-dependently suppress the protein and mRNA expressions of TLR2 and TLR4.	Vitamin D	30-39	toll like receptor 4	Homo sapiens	127-131
12670492-8	2003	The results implicate that both CYP2D25 and CYP27A1 contribute to the 25-hydroxylation in hepatocytes and are important in the bioactivation of vitamin D(3).	Vitamin D	144-153	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	32-39
18411217-11	2008	And it seems possible that vitamin D may be used as a therapeutic option by modulating TLR2 and TLR4 expression of monocytes in BD.	Vitamin D	27-36	toll like receptor 4	Homo sapiens	96-100
12520521-1	2003	Recent findings have indicated that calbindin-D(28k), the first known target of vitamin D action, is present in osteoblasts and protects against TNF and glucocorticoid induced apoptosis of osteoblastic cells.	Vitamin D	80-89	calbindin 1	Homo sapiens	36-45
12899516-9	2003	1,25(OH)2D regulates gene expression by activating the vitamin D receptor (VDR), a transcription factor, which, in combination with the retinoid X receptor (RXR) or retinoid A receptor (RAR), binds to its vitamin D response elements (VDRE) in the promoters of genes whose expression it regulates.	Vitamin D	55-64	retinoic acid receptor alpha	Homo sapiens	165-184
12899516-9	2003	1,25(OH)2D regulates gene expression by activating the vitamin D receptor (VDR), a transcription factor, which, in combination with the retinoid X receptor (RXR) or retinoid A receptor (RAR), binds to its vitamin D response elements (VDRE) in the promoters of genes whose expression it regulates.	Vitamin D	55-64	retinoic acid receptor alpha	Homo sapiens	186-189
12388409-11	2002	In conclusion, AQP3, AQP2, and p-AQP2 are downregulated and are likely to play critical roles in the development of polyuria associated with vitamin D-induced hypercalcemia.	Vitamin D	141-150	aquaporin 3 (Gill blood group)	Rattus norvegicus	15-19
17981260-0	2008	Relationship of vitamin D with calbindin D9k and D28k expression in ameloblasts.	Vitamin D	16-25	S100 calcium binding protein G	Rattus norvegicus	31-44
17981260-1	2008	OBJECTIVE: Calbindin D9k (CB9k) and D28k (CB28k) are intracellular soluble calcium-binding proteins, whose expressions are considered to be regulated by vitamin D.	Vitamin D	153-162	S100 calcium binding protein G	Rattus norvegicus	11-24
12388409-11	2002	In conclusion, AQP3, AQP2, and p-AQP2 are downregulated and are likely to play critical roles in the development of polyuria associated with vitamin D-induced hypercalcemia.	Vitamin D	141-150	aquaporin 2	Rattus norvegicus	21-25
17974622-1	2008	We have previously shown that the active form of vitamin D, 1,25 dihydroxyvitamin D3 [1,25(OH)(2)D(3)], has both genomic and rapid nongenomic effects in heart cells; however, the subcellular localization of the vitamin D receptor (VDR) in heart has not been studied.	Vitamin D	49-58	vitamin D receptor	Rattus norvegicus	211-229
12388409-11	2002	In conclusion, AQP3, AQP2, and p-AQP2 are downregulated and are likely to play critical roles in the development of polyuria associated with vitamin D-induced hypercalcemia.	Vitamin D	141-150	aquaporin 2	Rattus norvegicus	33-37
17974622-1	2008	We have previously shown that the active form of vitamin D, 1,25 dihydroxyvitamin D3 [1,25(OH)(2)D(3)], has both genomic and rapid nongenomic effects in heart cells; however, the subcellular localization of the vitamin D receptor (VDR) in heart has not been studied.	Vitamin D	49-58	vitamin D receptor	Rattus norvegicus	231-234
15775365-1	2002	Maxacalcitol, 1alpha,25-dihydroxy-22-oxavitamin D(3) (OCT), is a new synthetic analogue of 1alpha,25 (OH)(2)vitamin D(3) (1alpha,25 (OH)(2)D(3)), to be used for the treatment of secondary hyperparathyroidism.	Vitamin D	40-49	plexin A2	Homo sapiens	54-57
11834737-0	2002	A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands.	Vitamin D	30-39	vitamin D receptor	Rattus norvegicus	107-125
18213391-2	2008	Many epidermal genes induced by beta-catenin, including the stem cell marker keratin 15, contain vitamin D response elements (VDREs) and several are induced independently of TCF/Lef.	Vitamin D	97-106	catenin beta 1	Homo sapiens	32-44
18290716-9	2007	In either case, the 1,25(OH)(2)D ligand is required for the VDR to heterodimerize with the retinoid x receptor and compete away the dominant-negative acting, heterogeneous nuclear ribonucleoprotein (hnRNP)-related, vitamin D response element-binding proteins that inhibit hormone-directed transactivation of genes.	Vitamin D	215-224	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	158-197
17457036-5	2007	Various Ca(2+) mobilizing agents (vitamin D compounds, thapsigargin, ATP and ionomycin) activate MPK via activation of Ca(2+)/calmodulin-dependent kinase kinase-beta (CaMKK-beta), and his pathway is required for Ca(2+)-induced autophagy.	Vitamin D	34-43	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	167-177
12223078-6	2002	Inhibiting the inducible expression of TF by monocytes can be achieved by "deactivating" cytokines, such as interleukin (IL)-4, -10 and -13, or by certain prostanoids; by drugs that modify signal transduction, such as pentoxifylline, retinoic acid or vitamin D(3), or by antisense oligonucleotides.	Vitamin D	251-260	coagulation factor III, tissue factor	Homo sapiens	39-41
17470996-3	2007	Megalin-null mouse harbors similar bone phenotype to vitamin D deficiency.	Vitamin D	53-62	low density lipoprotein receptor-related protein 2	Mus musculus	0-7
11717447-4	2001	Knockout mice lacking the endocytic receptor megalin lose 25(OH) vitamin D(3) in the urine and develop bone disease.	Vitamin D	65-74	low density lipoprotein receptor-related protein 2	Mus musculus	45-52
17257576-6	2007	In contrast, the normal increase in C/EBPbeta protein that occurs shortly after the induction of differentiation occurs both in the presence and absence of vitamin D compounds, and the C/EBPbeta protein appears functional with respect to DNA binding and nuclear localization.	Vitamin D	156-165	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	36-45
11406617-10	2001	Antibodies against vitamin D and retinoic acid receptors used in supershift experiments showed that these nuclear receptors are involved in the regulation of decorin gene expression in articular chondrocytes.	Vitamin D	19-28	decorin	Homo sapiens	158-165
17234669-9	2007	CONCLUSIONS: Direct injection of OCT into the PTG enables the administration of the highly concentrated drug for specific binding to nuclear vitamin D binding sites, including VDR of PTC, which markedly suppresses the parathyroid hormone, improves the response to calcium and vitamin D and induces apoptosis in PTC.	Vitamin D	141-150	vitamin D receptor	Rattus norvegicus	176-179
11597934-0	2001	Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D.	Vitamin D	73-82	TNF receptor superfamily member 11B	Rattus norvegicus	0-15
17234669-9	2007	CONCLUSIONS: Direct injection of OCT into the PTG enables the administration of the highly concentrated drug for specific binding to nuclear vitamin D binding sites, including VDR of PTC, which markedly suppresses the parathyroid hormone, improves the response to calcium and vitamin D and induces apoptosis in PTC.	Vitamin D	276-285	vitamin D receptor	Rattus norvegicus	176-179
11597934-5	2001	Treatment for 96 hours with vitamin D caused widespread alizarin red staining for calcification in the aorta and the femoral, mesenteric, hepatic, renal, and carotid arteries, and osteoprotegerin completely prevented calcification in each of these arteries and reduced the levels of calcium and phosphate in the abdominal aorta to control levels (P&lt;0.001).	Vitamin D	28-37	TNF receptor superfamily member 11B	Rattus norvegicus	180-195
11597934-8	2001	Therefore, we conclude that doses of osteoprotegerin that inhibit bone resorption are able to potently inhibit the calcification of arteries that is induced by warfarin treatment and by vitamin D treatment.	Vitamin D	186-195	TNF receptor superfamily member 11B	Rattus norvegicus	37-52
16950800-9	2007	An interaction between the Bsm1 polymorphism and total vitamin D intake on SCC was observed, with the highest risk seen in women with the BB genotype and high vitamin D intake (OR=2.38; 95% CI=1.22-4.62) (P, interaction=0.08).	Vitamin D	55-64	serpin family B member 3	Homo sapiens	75-78
11389974-0	2001	Vitamin D(3) enhances the expression of I-mfa, an inhibitor of the MyoD family, in osteoblasts.	Vitamin D	0-9	MyoD family inhibitor	Mus musculus	40-45
16950800-9	2007	An interaction between the Bsm1 polymorphism and total vitamin D intake on SCC was observed, with the highest risk seen in women with the BB genotype and high vitamin D intake (OR=2.38; 95% CI=1.22-4.62) (P, interaction=0.08).	Vitamin D	159-168	serpin family B member 3	Homo sapiens	75-78
16950800-10	2007	This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC.	Vitamin D	121-130	serpin family B member 3	Homo sapiens	174-177
11237747-8	2001	NGFI-B nuclear receptors have been implicated in retinoic acid, vitamin D, and thyroid hormone signaling.	Vitamin D	64-73	nuclear receptor subfamily 4, group A, member 1	Mus musculus	0-6
17123747-0	2007	Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin.	Vitamin D	16-25	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	Mus musculus	89-96
17159355-0	2007	Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells.	Vitamin D	0-9	serpin family E member 1	Homo sapiens	45-78
17159355-0	2007	Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells.	Vitamin D	0-9	thrombomodulin	Homo sapiens	101-115
17020998-0	2006	Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1;Pten mutant mice.	Vitamin D	0-9	NK3 homeobox 1	Mus musculus	75-81
11400211-8	2001	microESI-MS analyses of RXR alpha in the presence of an osteopontin vitamin D DNA response element (OP-VDRE) showed RXR alpha homodimer/OP-VDRE complexes.	Vitamin D	68-77	secreted phosphoprotein 1	Homo sapiens	56-67
16995817-9	2006	Vitamin D-mediated osteoclastogenesis was examined in vitro using OSVDR osteoblasts and osteoblastic RANKL: osteoprotegerin (OPG) examined in vivo and in vitro after vitamin D treatment.	Vitamin D	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	101-106
16995817-12	2006	The vitamin D-mediated reduction in OPG expression was reduced in OSVDR osteoblasts in vivo and in vitro, resulting in a reduced RANKL/OPG ratio in OSVDR compared with wildtype, after exposure to vitamin D.	Vitamin D	4-13	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	129-134
11074597-0	2000	Binding of 1alpha,25-dihydroxyvitamin D(3) to annexin II: effect of vitamin D metabolites and calcium.	Vitamin D	30-39	annexin A2	Homo sapiens	46-56
16988533-6	2006	The therapeutic implication is that vitamin D supplementation in the range of 2000 IU/d, a dose comparable to the effect of summer, can benefit men monitored for rising PSA.	Vitamin D	36-45	kallikrein related peptidase 3	Homo sapiens	169-172
16613987-2	2006	Some of these effects of vitamin D are reminiscent of those orchestrated by the Wnt signaling pathway wherein stimulation of the membrane receptor Frizzled and its coreceptor LRP5 leads to activation of beta-catenin and subsequent transcription-mediated changes in osteoblast biology.	Vitamin D	25-34	catenin beta 1	Homo sapiens	203-215
11031222-4	2000	In vitamin D(3)-differentiated U-937 cells, thrombin-stimulated platelets increased TF expression as measured by mRNA quantification, flow cytometry, and procoagulant activity.	Vitamin D	3-12	coagulation factor III, tissue factor	Homo sapiens	84-86
16502312-5	2006	Cytochrome P450 (CYP27A1, CYP2R1, CYP27B1, CYP24A1) enzymes involved in vitamin D metabolism and two vitamin D(3)-target genes (ECaC1, CaBP-D9K) were assessed by real time RT-PCR in liver and kidneys.	Vitamin D	72-81	cytochrome P450, family 27, subfamily a, polypeptide 1	Rattus norvegicus	17-24
16502312-5	2006	Cytochrome P450 (CYP27A1, CYP2R1, CYP27B1, CYP24A1) enzymes involved in vitamin D metabolism and two vitamin D(3)-target genes (ECaC1, CaBP-D9K) were assessed by real time RT-PCR in liver and kidneys.	Vitamin D	72-81	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	34-41
16816472-1	2006	CYP27A1, CYP27B1, and CYP24A1 are members of the cytochrome P450 superfamily, and key enzymes of vitamin D(3) metabolism.	Vitamin D	97-106	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
16816472-8	2006	Surprisingly, more than 70% of the vitamin D metabolites observed in a living body were found to be the products formed by the activities of CYP27A1, CYP27B1, and CYP24A1.	Vitamin D	35-44	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	141-148
16816477-3	2006	Our studies aimed particularly at separating the differentiation-inducing effect/cell growth-inhibitory effect and the calcemic effect of active vitamin D led to the development of two characteristic analogs, OCT and ED-71.	Vitamin D	145-154	plexin A2	Homo sapiens	209-212
10891358-0	2000	Metabolism of vitamin D(3) by human CYP27A1.	Vitamin D	14-23	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	36-43
16533909-8	2006	These results indicate that the activation of BMP/Smad signaling by the Gemini vitamin D(3) analog Ro3582 may be through the production of BMP ligands, including BMP-2 and BMP-6, and/or down-regulation of the inhibitory Smad6.	Vitamin D	79-88	bone morphogenetic protein 1	Homo sapiens	46-49
16533909-8	2006	These results indicate that the activation of BMP/Smad signaling by the Gemini vitamin D(3) analog Ro3582 may be through the production of BMP ligands, including BMP-2 and BMP-6, and/or down-regulation of the inhibitory Smad6.	Vitamin D	79-88	bone morphogenetic protein 1	Homo sapiens	139-142
16533909-8	2006	These results indicate that the activation of BMP/Smad signaling by the Gemini vitamin D(3) analog Ro3582 may be through the production of BMP ligands, including BMP-2 and BMP-6, and/or down-regulation of the inhibitory Smad6.	Vitamin D	79-88	SMAD family member 6	Homo sapiens	220-225
10891358-5	2000	These results suggest that human CYP27A1 catalyzes multiple reactions and multiple-step metabolism toward vitamin D(3).	Vitamin D	106-115	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	33-40
10875229-0	2000	Transgenic analysis of the response of the rat calbindin-D 9k gene to vitamin D.	Vitamin D	70-79	S100 calcium binding protein G	Rattus norvegicus	47-61
10825392-1	2000	The vitamin D receptor (VDR) is the nuclear receptor for 1, 25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] that acts as a ligand-dependent transcription factor via combined contact with coactivator proteins (steroid receptor coactivator-1, transcriptional intermediary factor 2, and receptor associated coactivator 3) and specific DNA binding sites [vitamin D response elements (VDREs)].	Vitamin D	4-13	nuclear receptor coactivator 3	Homo sapiens	284-317
16584175-1	2006	Cytochrome P450 27A1 (P450 27A1 or CYP27A1) is an important enzyme that participates in different pathways of cholesterol degradation as well as in the activation of vitamin D(3).	Vitamin D	166-175	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	35-42
10702588-3	2000	The extra vitamin D resulted in greater serum 25(OH)D (51 +/- 3, vs. control of 21 +/- 2 nmol/L), and kidney mRNA for vitamin D receptor [VDR mRNA] (P = 0.	Vitamin D	10-19	vitamin D receptor	Rattus norvegicus	118-136
16457860-3	2006	Our research has focused on the rapid effects of 1alpha,25(OH)(2) Vitamin D(3) [1,25D] on L-type Ca(2+) [L-Ca] and DIDS-sensitive Cl(-) channels in osteoblasts.	Vitamin D	66-75	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	105-109
16522169-4	2006	A dose-related effect of blueberry, green tea, catechin, carnosine, and vitamin D(3) was observed on proliferation with human bone marrow as compared with human granulocyte-macrophage colony-stimulating factor (hGM-CSF).	Vitamin D	72-81	colony stimulating factor 2	Homo sapiens	161-209
10702588-3	2000	The extra vitamin D resulted in greater serum 25(OH)D (51 +/- 3, vs. control of 21 +/- 2 nmol/L), and kidney mRNA for vitamin D receptor [VDR mRNA] (P = 0.	Vitamin D	10-19	vitamin D receptor	Rattus norvegicus	138-141
10640426-0	2000	Cell cycle arrest induced by the vitamin D(3) analog EB1089 in NCI-H929 myeloma cells is associated with induction of the cyclin-dependent kinase inhibitor p27.	Vitamin D	33-42	proliferating cell nuclear antigen	Homo sapiens	122-128
10724336-3	2000	In view of our previous studies showing up-regulation of vitamin D receptors (VDR) in the duodenal mucosa and in osteoblasts, the present study was designed to address a possible interaction between estrogen and the vitamin D endocrine system in the colonic mucosa.	Vitamin D	57-66	vitamin D receptor	Rattus norvegicus	78-81
16213938-5	2005	RESULTS: Vitamin D(3) with or without docetaxel was similarly effective in reducing CD34(+) cell levels within the spleen, lymph nodes, and tumor.	Vitamin D	9-18	CD34 antigen	Mus musculus	84-88
10567209-6	1999	The purified vitamin D receptor binds to the vitamin D response elements of osteopontin and osteocalcin genes as a homodimer or as a heterodimer with the retinoid X receptor-alphaDeltaAB and we were able to purify these complexes in quantities sufficient for crystallization studies.	Vitamin D	13-22	secreted phosphoprotein 1	Homo sapiens	76-87
10527952-10	1999	The levels of type III Na/P(i) co-transporter PiT-2 mRNA were increased 24 and 48 h after 1,25-(OH)(2)D(3) administration to vitamin D-deficient animals, whereas PiUS and the type IIb Na/P(i) co-transporter mRNA levels were unchanged.	Vitamin D	125-134	solute carrier family 20 member 2	Rattus norvegicus	46-51
10508929-1	1999	Regulation by vitamin D(3) of expression of the genes for stanniocalcins 1 and 2 (STC-1 and STC-2) was studied and their levels were shown to be oppositely regulated in the kidney and to remain unaffected in the ovary.	Vitamin D	14-23	stanniocalcin 2	Rattus norvegicus	92-97
10430650-4	1999	However, a simultaneous 8-week administration of conjugated estrogens, bisphosphonate, and vitamin D(3) analog markedly augmented the BMC values to 110.3%, 110.1%, and 114.4%, respectively, of those in the rats treated with the GnRH agonist alone.	Vitamin D	91-100	gonadotropin releasing hormone 1	Rattus norvegicus	228-232
10404392-1	1999	The ability of vitamin D receptor-retinoid X receptor (VDR-RXR) heterodimers to induce a DNA bend upon binding to various vitamin D response elements (VDRE) has been investigated by circular permutation and phasing analysis.	Vitamin D	15-24	vitamin D receptor	Rattus norvegicus	55-58
10342883-0	1999	Vitamin D represses retinoic acid-dependent transactivation of the retinoic acid receptor-beta2 promoter: the AF-2 domain of the vitamin D receptor is required for transrepression.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	129-147
10342883-3	1999	Incubation with vitamin D markedly reduced the response to RA caused by transcriptional interference of the vitamin D receptor (VDR) on the RARE.	Vitamin D	16-25	vitamin D receptor	Rattus norvegicus	108-126
10342883-3	1999	Incubation with vitamin D markedly reduced the response to RA caused by transcriptional interference of the vitamin D receptor (VDR) on the RARE.	Vitamin D	16-25	vitamin D receptor	Rattus norvegicus	128-131
10342883-5	1999	Overexpression of RXR in GH4C1 cells, as well as incubation with BMS649 (a RXR-specific ligand), increased the inhibitory effect of vitamin D, suggesting that the VDR/RXR heterodimer is the repressive species and that titration of RXR is not responsible for this inhibition.	Vitamin D	132-141	vitamin D receptor	Rattus norvegicus	163-166
10342883-7	1999	Furthermore, the ability to mediate transrepression by vitamin D was strongly decreased when a mutant VDR in which the last 12 C-terminal aminoacids have been deleted (VDR deltaAF-2) was used.	Vitamin D	55-64	vitamin D receptor	Rattus norvegicus	102-105
10342883-7	1999	Furthermore, the ability to mediate transrepression by vitamin D was strongly decreased when a mutant VDR in which the last 12 C-terminal aminoacids have been deleted (VDR deltaAF-2) was used.	Vitamin D	55-64	vitamin D receptor	Rattus norvegicus	168-171
10342883-8	1999	Because this region contains the domain responsible for ligand-dependent recruitment of coactivators, titration of common coactivators for VDR and RAR could be involved in the inhibitory effect of vitamin D.	Vitamin D	197-206	vitamin D receptor	Rattus norvegicus	139-142
9886808-0	1999	AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation.	Vitamin D	9-18	vitamin D receptor	Rattus norvegicus	29-32
9886808-0	1999	AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation.	Vitamin D	9-18	vitamin D receptor	Rattus norvegicus	85-88
9735329-3	1998	Moreover, this activation of PKC-betaII by 1,25-dihydroxyvitamin D3 treatment of isolated colonocytes was shown to be lost in cells from vitamin D-deficient rats and, at least partially, restored by repleting these animals with this secosteroid for 7 days.	Vitamin D	57-66	phospholipase C, beta 2	Rattus norvegicus	29-39
9749832-10	1998	These results indicate that a critical nucleotide sequence is necessary for the binding to the VDR and for mediating the vitamin D effect, and suggest the different regulation between the rat and human 24-hydroxylase gene.	Vitamin D	121-130	vitamin D receptor	Rattus norvegicus	95-98
9720659-10	1998	These results support the role of beta2m as a regulator of bone metabolism and its potential use as a marker of high bone turnover in post-menopausal women, specially in elderly women with vitamin D deficiency and secondary hyperparathyroidism.	Vitamin D	189-198	beta-2-microglobulin	Homo sapiens	34-40
9528970-1	1998	We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats.	Vitamin D	26-35	vitamin D receptor	Rattus norvegicus	117-135
9528970-1	1998	We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats.	Vitamin D	69-78	vitamin D receptor	Rattus norvegicus	117-135
9528970-4	1998	Vitamin D deficiency decreased VDR mRNA in all three tissues.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	31-34
9528970-5	1998	Treatment with vitamin D or calcium-lactose reestablished the VDR mRNA content of the epidermis, but not that of the kidneys, and only the calcium-lactose diet increased duodenal VDR mRNA.	Vitamin D	15-24	vitamin D receptor	Rattus norvegicus	62-65
9528970-5	1998	Treatment with vitamin D or calcium-lactose reestablished the VDR mRNA content of the epidermis, but not that of the kidneys, and only the calcium-lactose diet increased duodenal VDR mRNA.	Vitamin D	15-24	vitamin D receptor	Rattus norvegicus	179-182
9528970-8	1998	The expression of VDR was decreased by vitamin D deficiency and returned to control values after vitamin D or calcium supplementation.	Vitamin D	39-48	vitamin D receptor	Rattus norvegicus	18-21
9528970-8	1998	The expression of VDR was decreased by vitamin D deficiency and returned to control values after vitamin D or calcium supplementation.	Vitamin D	97-106	vitamin D receptor	Rattus norvegicus	18-21
9528970-9	1998	Vitamin D treatment, but not calcium, induced VDR expression in the normally immature population.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	46-49
9528970-10	1998	Vitamin D and calcium, therefore, have distinct, tissue-specific effects on VDR.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	76-79
9541257-0	1998	Characteristics of vitamin D3 receptor (VDR) binding to the vitamin D response element (VDRE) in rat bone sialoprotein gene promoter.	Vitamin D	19-28	vitamin D receptor	Rattus norvegicus	40-43
9333117-0	1997	Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes.	Vitamin D	86-95	bone gamma-carboxyglutamate protein 2	Mus musculus	12-23
15528275-0	2005	Identification of a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 preadipocytes.	Vitamin D	31-40	insulin induced gene 2	Mus musculus	72-79
9333117-12	1997	This species difference in vitamin D regulation of osteocalcin appears to result from the failure of 1,25(OH)2D3 to transcriptionally activate the mouse osteocalcin gene.	Vitamin D	27-36	bone gamma-carboxyglutamate protein 2	Mus musculus	51-62
9333117-12	1997	This species difference in vitamin D regulation of osteocalcin appears to result from the failure of 1,25(OH)2D3 to transcriptionally activate the mouse osteocalcin gene.	Vitamin D	27-36	bone gamma-carboxyglutamate protein 2	Mus musculus	153-164
9213220-4	1997	Interestingly, the simultaneous expression of the native vitamin D receptor and the retinoid X receptor beta resulted in a ligand independent transactivation of the lacZ reporter gene coupled to a mouse osteopontin vitamin D response element.	Vitamin D	57-66	retinoid X receptor beta	Mus musculus	84-108
9112412-5	1997	Several lines of evidence are presented that suggest this response is caused by sequence specific properties of the mouse OC vitamin D response element.	Vitamin D	125-134	bone gamma-carboxyglutamate protein 2	Mus musculus	122-124
15485861-4	2004	The decrease is not due to transcriptional repression through the putative vitamin D response element present in the 5" regulatory region of hTERT gene.	Vitamin D	75-84	telomerase reverse transcriptase	Homo sapiens	141-146
15211579-11	2004	These results show that TNF-alpha inhibition of vitamin D-action includes stable integration of p65 in the VDR transcription complex.	Vitamin D	48-57	vitamin D receptor	Rattus norvegicus	107-110
9168939-2	1997	The regulation of the vitamin D catabolism by Pi, GH and IGF-I is less clear.	Vitamin D	22-31	insulin-like growth factor 1	Rattus norvegicus	57-62
15235930-1	2004	BACKGROUND: Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue.	Vitamin D	60-69	plexin A2	Homo sapiens	44-47
9108352-9	1997	Overexpression of HES-1 suppressed the vitamin D-dependent upregulation of osteopontin gene expression in these cells.	Vitamin D	39-48	hes family bHLH transcription factor 1	Rattus norvegicus	18-23
9108352-10	1997	Vitamin D suppression of HES-1 gene expression was also observed in normal rat calvaria-derived osteoblast-enriched cells.	Vitamin D	0-9	hes family bHLH transcription factor 1	Rattus norvegicus	25-30
9058197-3	1997	Because the actions of 1,25-(OH)2D3 are mediated through the vitamin D receptor (VDR), that is a DNA binding transcription factor, vitamin D regulated genes should have VDR binding sites in their regulatory regions.	Vitamin D	61-70	vitamin D receptor	Rattus norvegicus	169-172
9058197-4	1997	In this paper, we describe a novel vitamin D response element (VDRE)-containing sequence, clone 3, which was isolated through binding to VDR.	Vitamin D	35-44	vitamin D receptor	Rattus norvegicus	63-66
8761946-1	1996	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)transactivates the avian beta 3 integrin gene whose promoter contains at least two vitamin D response elements, one of which is in close proximity to a candidate AP1 site (TGACTCA).	Vitamin D	14-23	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	63-69
7575591-0	1995	Binding of vitamin D to low-density-lipoprotein (LDL) and LDL receptor-mediated pathway into cells.	Vitamin D	11-20	low density lipoprotein receptor	Homo sapiens	58-70
7558419-7	1995	This suggests that VDR mRNA abundance could nevertheless be important for vitamin-D-related c-myc-independent growth control in Caco-2 cells.	Vitamin D	74-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
7622489-0	1995	Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism.	Vitamin D	127-136	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	98-103
7615822-1	1995	The genomic action of calcitriol (1,25-dihydroxy-vitamin D3) is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs).	Vitamin D	49-58	vitamin D receptor	Rattus norvegicus	125-128
7798277-0	1994	Evidence for the uptake of a vitamin D analogue (OCT) by a human carcinoma and its effect of suppressing the transcription of parathyroid hormone-related peptide gene in vivo.	Vitamin D	29-38	plexin A2	Homo sapiens	49-52
7890807-8	1994	These results indicate that a vitamin D response element similar to that described for other vitamin D responsive genes (osteocalcin and osteopontin) does not alone mediate the repression of COL1A1 by 1,25-dihydroxyvitamin D3.	Vitamin D	30-39	secreted phosphoprotein 1	Homo sapiens	137-148
7890807-8	1994	These results indicate that a vitamin D response element similar to that described for other vitamin D responsive genes (osteocalcin and osteopontin) does not alone mediate the repression of COL1A1 by 1,25-dihydroxyvitamin D3.	Vitamin D	93-102	secreted phosphoprotein 1	Homo sapiens	137-148
7929052-6	1994	Thus, homologation of carbons 26 and 27 of the vitamin D compound likely sterically hinders vitamin D 25-hydroxylase.	Vitamin D	47-56	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	92-116
8170472-1	1994	The human vitamin D receptor (hVDR) requires another nuclear protein(s), designated receptor auxiliary factor (RAF), for optimal binding to the vitamin D-responsive element (VDRE).	Vitamin D	10-19	vitamin D receptor	Homo sapiens	30-34
14978251-6	2004	Vitamin D stimulated endogenous SULT2A1 expression and induced transfected human, mouse, and rat SULT2A1 promoters in liver and intestinal cells upon cotransfection with VDR.	Vitamin D	0-9	sulfotransferase family 2A member 1	Rattus norvegicus	97-104
14978251-6	2004	Vitamin D stimulated endogenous SULT2A1 expression and induced transfected human, mouse, and rat SULT2A1 promoters in liver and intestinal cells upon cotransfection with VDR.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	170-173
16982574-7	2004	Characteristic examples are the metabolic pathways of the corticotropin-releasing hormone/propiomelanocortin axis, steroidogenesis, vitamin D and retinoids.	Vitamin D	132-141	corticotropin releasing hormone	Homo sapiens	58-89
12960019-2	2003	To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR).	Vitamin D	38-47	vitamin D receptor	Rattus norvegicus	58-61
12960019-2	2003	To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR).	Vitamin D	38-47	vitamin D receptor	Rattus norvegicus	215-218
12893881-9	2003	Both DRIP205 and SRC-3 potentiated vitamin D-induced transcription in proliferating cells, but during differentiation, DRIP205 was no longer effective.	Vitamin D	35-44	nuclear receptor coactivator 3	Homo sapiens	17-22
12925957-0	2003	Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk.	Vitamin D	145-154	insulin like growth factor binding protein 3	Homo sapiens	43-49
14507860-0	2003	Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma.	Vitamin D	0-9	H3 histone pseudogene 16	Homo sapiens	34-37
14507860-12	2003	There was an increase in staining for p53 and p21 in areas associated with cell death in specimens treated with vitamin D analogues.	Vitamin D	112-121	H3 histone pseudogene 16	Homo sapiens	46-49
15775165-3	2003	The direct effects of vitamin D on skeletal muscle cells include induction of transcription factors such as c-myc (genomic action) ;and activation of Ca channels, Src tyrosine kinase and MAP kinase (non-genomic action).	Vitamin D	22-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
12746312-0	2003	Vitamin D and dexamethasone inversely regulate parathyroid hormone-induced regulator of G protein signaling-2 expression in osteoblast-like cells.	Vitamin D	0-9	regulator of G-protein signaling 2	Rattus norvegicus	75-109
12761878-0	2003	Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes.	Vitamin D	0-9	fibroblast growth factor receptor 2	Homo sapiens	43-78
12742547-6	2003	Excessive non-toxic Vitamin D(3) supplementation resulted in decreased bone remodeling and focal enlargement of the growth plate with morphology resembling those induced by administration of CT.	Vitamin D	20-29	calcitonin	Canis lupus familiaris	191-193
12671190-4	2003	A recent study suggests that megalin, a member of the LDLR gene family that mediates the cellular uptake of vitamin D carrier protein, may also modulate vitamin D-related gene transcription through sequestration of a component of the vitamin D receptor transcriptional complex.	Vitamin D	108-117	low density lipoprotein receptor	Homo sapiens	54-58
12671190-4	2003	A recent study suggests that megalin, a member of the LDLR gene family that mediates the cellular uptake of vitamin D carrier protein, may also modulate vitamin D-related gene transcription through sequestration of a component of the vitamin D receptor transcriptional complex.	Vitamin D	153-162	low density lipoprotein receptor	Homo sapiens	54-58
12757166-11	2003	There seems to be a connection between inflammatory pancreas destruction (Cambridge classification), exocrine insufficiency (fecal elastase 1), and perhaps even the characteristics of sterol-binding of pancreatic elastase 1, which seems to be relevant for vitamin D supply.	Vitamin D	256-265	chymotrypsin like elastase 3B	Homo sapiens	202-223
12759576-8	2003	However, the expression of vitamin D-dependent P21 gene on the mRNA level was not decreased in these cancers.	Vitamin D	27-36	H3 histone pseudogene 16	Homo sapiens	47-50
12899526-2	2003	There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the vitamin D 25-hydroxylase (25-OHase) and the 1alpha-hydroxylase (1alpha-OHase).	Vitamin D	90-99	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	105-129
12899535-1	2003	Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes.	Vitamin D	33-42	interleukin 1 alpha	Homo sapiens	123-136
12371967-7	2002	CONCLUSIONS: Expression profiling confirms a crucial role for megalin in renal vitamin D metabolism.	Vitamin D	79-88	low density lipoprotein receptor-related protein 2	Mus musculus	62-69
12372416-0	2002	Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells.	Vitamin D	0-9	colony stimulating factor 1	Homo sapiens	54-59
12408227-0	2002	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells.	Vitamin D	0-9	phosphatase and tensin homolog	Homo sapiens	113-117
12198242-5	2002	The vitamin D response element is sufficient for the PKA enhancement of VDR-mediated transcription and is also sufficient to observe the inhibitory effect of ICER.	Vitamin D	4-13	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	53-56
12198242-5	2002	The vitamin D response element is sufficient for the PKA enhancement of VDR-mediated transcription and is also sufficient to observe the inhibitory effect of ICER.	Vitamin D	4-13	vitamin D receptor	Rattus norvegicus	72-75
12198242-7	2002	This study provides evidence for the first time that ICER has a key regulatory role in the PKA enhancement of VDR transcription and therefore in the cross-talk between the PKA signaling pathway and the vitamin D endocrine system.	Vitamin D	202-211	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	91-94
12198242-7	2002	This study provides evidence for the first time that ICER has a key regulatory role in the PKA enhancement of VDR transcription and therefore in the cross-talk between the PKA signaling pathway and the vitamin D endocrine system.	Vitamin D	202-211	vitamin D receptor	Rattus norvegicus	110-113
12198242-7	2002	This study provides evidence for the first time that ICER has a key regulatory role in the PKA enhancement of VDR transcription and therefore in the cross-talk between the PKA signaling pathway and the vitamin D endocrine system.	Vitamin D	202-211	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	172-175
12145693-3	2002	A novel synthetic vitamin D(3)derivative, 22-oxa-1,25-dihydroxyvitamin D(3) (OCT: oxacarcitriol) shows a more potent differentiation-inducing ability among myeloid leukemia cells in vitro with much lesser extent of the induction of hypercalcemia in vivo as compared to the effects of 1alpha,25(OH)(2)D(3).	Vitamin D	18-27	plexin A2	Homo sapiens	77-80
11991950-1	2002	The fully active dihydroxylated metabolite of vitamin D(3) induces the expression of CYP3A4 and, to a lesser extent, CYP2B6 and CYP2C9 genes in normal differentiated primary human hepatocytes.	Vitamin D	46-55	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	128-134
15775358-4	2002	The work on OCT and MC903 vigorously stimulated research world-wide in the development of vitamin D analogs into pharmaceutical products.	Vitamin D	90-99	plexin A2	Homo sapiens	12-15
15775359-1	2002	1alpha,25-dihydroxy-22-oxavitamin D(3) (maxacalcitol;OCT), a vitamin D analogue with reduced calcemic activity, showed potency 10 times greater than 1alpha,25 (OH) (2)D(3) in differentiation induction of HL-60 cells.	Vitamin D	26-35	plexin A2	Homo sapiens	53-56
15775360-12	2002	In conclusion, our results suggest that OCT is a useful vitamin D(3) analogue, which has a potentially larger therapeutic window than that of 1,25 (OH) (2)D(3) and which is available for IV/oral, for the management of secondary hyperparathyroidism.	Vitamin D	56-65	plexin A2	Homo sapiens	40-43
11834737-7	2002	The synthetic vitamin D analog KH1060 is a more potent stimulator of transcription and inducer of VDRE binding of VDR/RXR in the presence of nuclear factors isolated from ROS 17/2.8 osteoblast-like cells than the natural ligand 1,25-(OH)(2)D(3).	Vitamin D	14-23	vitamin D receptor	Rattus norvegicus	98-101
11839571-0	2002	Vitamin D arrests thyroid carcinoma cell growth and induces p27 dephosphorylation and accumulation through PTEN/akt-dependent and -independent pathways.	Vitamin D	0-9	interferon alpha inducible protein 27	Homo sapiens	60-63
11839571-0	2002	Vitamin D arrests thyroid carcinoma cell growth and induces p27 dephosphorylation and accumulation through PTEN/akt-dependent and -independent pathways.	Vitamin D	0-9	phosphatase and tensin homolog	Homo sapiens	107-111
11830528-19	2002	Our results indicate that a noncalcemic analogue of vitamin D can significantly decrease intestinal tumor load in Apc(min) mice without severe toxic side effects and suggest that these compounds may have utility as chemopreventive agents in groups at high-risk for colon cancer.	Vitamin D	52-61	APC, WNT signaling pathway regulator	Mus musculus	114-117
12362981-4	2002	The induction of leukemia cell differentiation in response to the analogs of vitamin D was inhibited by LY294002 (phosphatidylinositol 3-kinase inhibitor), PD98059 (inhibitor of MEK1,2, an upstream regulator of extracellular-signal regulated kinase) and rapamycin (p70S6K inhibitor) pointing out that activation of signal transduction pathways unrelated to nVDR is necessary for differentiation.	Vitamin D	77-86	mitogen-activated protein kinase kinase 1	Homo sapiens	178-184
12362981-4	2002	The induction of leukemia cell differentiation in response to the analogs of vitamin D was inhibited by LY294002 (phosphatidylinositol 3-kinase inhibitor), PD98059 (inhibitor of MEK1,2, an upstream regulator of extracellular-signal regulated kinase) and rapamycin (p70S6K inhibitor) pointing out that activation of signal transduction pathways unrelated to nVDR is necessary for differentiation.	Vitamin D	77-86	ribosomal protein S6 kinase B1	Homo sapiens	265-271
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	secreted phosphoprotein 1	Homo sapiens	199-210
12489183-2	2002	The present study is devoted to amelogenin, enamelin, ameloblastin, and dentin sialophosphoprotein (DSPP) expression in both the epithelium and mesenchyme of vitamin D-deficient rat incisors.	Vitamin D	158-167	dentin sialophosphoprotein	Rattus norvegicus	100-104
11751074-7	2002	CONCLUSIONS: Our findings suggest a coordinate regulation of Phex mRNA expression in lungs and bone and vitamin D metabolism during GH- and IGF-I-stimulated growth.	Vitamin D	104-113	insulin-like growth factor 1	Rattus norvegicus	140-145
11703581-12	2001	Parathyroid hormone, vitamin D(3), calcium, phosphate and some cytokines increase OPN expression in vitro or in vivo, whereas female sex hormones and angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists decrease OPN expression in some renal damage states.	Vitamin D	21-30	secreted phosphoprotein 1	Homo sapiens	82-85
11604234-0	2001	Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells.	Vitamin D	24-33	insulin like growth factor 2	Homo sapiens	68-97
11592788-9	2001	RESULTS: Vitamin D supplementation decreased VDR and Smad3 protein levels.	Vitamin D	9-18	vitamin D receptor	Rattus norvegicus	45-48
11433085-2	2001	Conventional treatment of XLH with oral phosphate and vitamin D is associated with increased urinary calcium excretion and nephrocalcinosis.	Vitamin D	54-63	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	26-29
11295155-9	2001	Vitamin D offers a protection from genotoxic effects of Vitamin D deficiency by increasing the insulin receptor gene expression and BSP (bone sialoprotein), bone-remodeling by decreasing the osteopontin (OPN) m-RNAs, maintaining the normal epidermal structure and enamel matrix.	Vitamin D	0-9	secreted phosphoprotein 1	Homo sapiens	191-202
11295155-9	2001	Vitamin D offers a protection from genotoxic effects of Vitamin D deficiency by increasing the insulin receptor gene expression and BSP (bone sialoprotein), bone-remodeling by decreasing the osteopontin (OPN) m-RNAs, maintaining the normal epidermal structure and enamel matrix.	Vitamin D	0-9	secreted phosphoprotein 1	Homo sapiens	204-207
11295155-11	2001	The supportive role of Vitamin D in placental function is also evident by its influence on human placental lactogen (hpl) gene transcription accompanied by increase hpl m-RNA levels.	Vitamin D	23-32	galectin 1	Homo sapiens	117-120
11295155-11	2001	The supportive role of Vitamin D in placental function is also evident by its influence on human placental lactogen (hpl) gene transcription accompanied by increase hpl m-RNA levels.	Vitamin D	23-32	galectin 1	Homo sapiens	165-168
11179749-0	2001	Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D(3): CYP27 in epidermis completes the set of essential vitamin D(3)-hydroxylases.	Vitamin D	81-90	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	95-100
11172626-0	2001	Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review).	Vitamin D	48-57	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	0-15
11311530-12	2001	In combination with reports of a neuroprotective role for vitamin D in hippocampal cell survival, these data suggest that the endogenous vitamin D receptor may mitigate processes related to cellular homeostasis, perhaps through a calcium buffering mechanism.	Vitamin D	58-67	vitamin D receptor	Rattus norvegicus	137-155
11104746-1	2000	BACKGROUND: We have recently found that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], exerts anticoagulant effects by upregulating the expression of an anticoagulant glycoprotein, thrombomodulin (TM), and downregulating the expression of a critical coagulation factor, tissue factor (TF), in monocytic cells including human peripheral monocytes.	Vitamin D	68-77	thrombomodulin	Homo sapiens	224-238
11104746-1	2000	BACKGROUND: We have recently found that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], exerts anticoagulant effects by upregulating the expression of an anticoagulant glycoprotein, thrombomodulin (TM), and downregulating the expression of a critical coagulation factor, tissue factor (TF), in monocytic cells including human peripheral monocytes.	Vitamin D	68-77	coagulation factor III, tissue factor	Homo sapiens	313-326
11104746-1	2000	BACKGROUND: We have recently found that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], exerts anticoagulant effects by upregulating the expression of an anticoagulant glycoprotein, thrombomodulin (TM), and downregulating the expression of a critical coagulation factor, tissue factor (TF), in monocytic cells including human peripheral monocytes.	Vitamin D	68-77	coagulation factor III, tissue factor	Homo sapiens	328-330
10924511-2	2000	The metabolic activation of the prohormone vitamin D(3) requires a 25-hydroxylation that has been reported to be catalyzed by both mitochondrial CYP27A and a microsomal vitamin D(3) 25-hydroxylase in the liver.	Vitamin D	43-52	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	169-196
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Vitamin D	69-78	C-terminal Src kinase	Gallus gallus	14-24
10875240-4	2000	Cell-associated IGFBP-3, and immunoreactive IGFBP-3 species of 20 kDa and 30 kDa were also increased in response to vitamin D plus DHT.	Vitamin D	116-125	insulin like growth factor binding protein 3	Homo sapiens	16-23
10875240-4	2000	Cell-associated IGFBP-3, and immunoreactive IGFBP-3 species of 20 kDa and 30 kDa were also increased in response to vitamin D plus DHT.	Vitamin D	116-125	insulin like growth factor binding protein 3	Homo sapiens	44-51
10875240-5	2000	A combination of vitamin D and DHT increased DNA synthesis in LNCaP cells 3-fold, and this was at least partly mediated by endogenous IGFBP-3 because anti-IGFBP-3 IgG, but not nonimmune serum IgG, reduced the stimulatory effect of vitamin D and DHT from 293 +/- 11.6% to 161 +/- 30.7% of control levels (P &lt; 0.0001).	Vitamin D	17-26	insulin like growth factor binding protein 3	Homo sapiens	134-141
10875240-5	2000	A combination of vitamin D and DHT increased DNA synthesis in LNCaP cells 3-fold, and this was at least partly mediated by endogenous IGFBP-3 because anti-IGFBP-3 IgG, but not nonimmune serum IgG, reduced the stimulatory effect of vitamin D and DHT from 293 +/- 11.6% to 161 +/- 30.7% of control levels (P &lt; 0.0001).	Vitamin D	17-26	insulin like growth factor binding protein 3	Homo sapiens	155-162
10875240-5	2000	A combination of vitamin D and DHT increased DNA synthesis in LNCaP cells 3-fold, and this was at least partly mediated by endogenous IGFBP-3 because anti-IGFBP-3 IgG, but not nonimmune serum IgG, reduced the stimulatory effect of vitamin D and DHT from 293 +/- 11.6% to 161 +/- 30.7% of control levels (P &lt; 0.0001).	Vitamin D	231-240	insulin like growth factor binding protein 3	Homo sapiens	134-141
10875240-6	2000	Basal and DHT plus vitamin D-stimulated thymidine incorporation was significantly increased by 50 ng/ml human plasma-derived purified IGFBP-3.	Vitamin D	19-28	insulin like growth factor binding protein 3	Homo sapiens	134-141
10809755-7	2000	Vitamin D(3) and interferon-gamma, which stimulate differentiation of HL-60 cells into monocyte-like cells, also induced VacA sensitivity and expression of RPTPbeta mRNA, whereas 1.	Vitamin D	0-9	protein tyrosine phosphatase receptor type Z1	Homo sapiens	156-164
10677578-8	2000	Furthermore, as shown in gel mobility shift assays, both compounds clearly induced VDR binding to vitamin D response elements.	Vitamin D	98-107	vitamin D receptor	Rattus norvegicus	83-86
10677586-9	2000	Although earlier extensive structure-activity studies of vitamin D analogues showed stereochemistry at the C-1, C-3, and C-20 of 1alpha,25(OH)(2)D(3) to be the key structural motif for vitamin D action, our results clearly demonstrated that stereochemistry at the C-2 is also an important structural motif for vitamin D action and imply that 2-methyl substitution possibly induces conformational changes in ring A depending upon the combinations of configurations of the C-1 and C-3 hydroxyl groups with C-20 stereochemistry.	Vitamin D	57-66	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	107-115
10677586-9	2000	Although earlier extensive structure-activity studies of vitamin D analogues showed stereochemistry at the C-1, C-3, and C-20 of 1alpha,25(OH)(2)D(3) to be the key structural motif for vitamin D action, our results clearly demonstrated that stereochemistry at the C-2 is also an important structural motif for vitamin D action and imply that 2-methyl substitution possibly induces conformational changes in ring A depending upon the combinations of configurations of the C-1 and C-3 hydroxyl groups with C-20 stereochemistry.	Vitamin D	57-66	complement C2	Homo sapiens	121-124
10677586-9	2000	Although earlier extensive structure-activity studies of vitamin D analogues showed stereochemistry at the C-1, C-3, and C-20 of 1alpha,25(OH)(2)D(3) to be the key structural motif for vitamin D action, our results clearly demonstrated that stereochemistry at the C-2 is also an important structural motif for vitamin D action and imply that 2-methyl substitution possibly induces conformational changes in ring A depending upon the combinations of configurations of the C-1 and C-3 hydroxyl groups with C-20 stereochemistry.	Vitamin D	185-194	complement C2	Homo sapiens	121-124
10677586-9	2000	Although earlier extensive structure-activity studies of vitamin D analogues showed stereochemistry at the C-1, C-3, and C-20 of 1alpha,25(OH)(2)D(3) to be the key structural motif for vitamin D action, our results clearly demonstrated that stereochemistry at the C-2 is also an important structural motif for vitamin D action and imply that 2-methyl substitution possibly induces conformational changes in ring A depending upon the combinations of configurations of the C-1 and C-3 hydroxyl groups with C-20 stereochemistry.	Vitamin D	185-194	complement C2	Homo sapiens	121-124
10694472-2	2000	The expression of p27(Kip1) has been shown to be controlled by a posttranslational mechanism, although vitamin D(3) and neuronal differentiation can also induce its mRNA.	Vitamin D	103-112	interferon alpha inducible protein 27	Homo sapiens	18-21
10694472-2	2000	The expression of p27(Kip1) has been shown to be controlled by a posttranslational mechanism, although vitamin D(3) and neuronal differentiation can also induce its mRNA.	Vitamin D	103-112	cyclin dependent kinase inhibitor 1B	Homo sapiens	22-26
10767176-1	2000	Lowe oculocerebrorenal syndrome (OCRL) (MIM 309000) is a rare X-linked multisystem disorder characterized by congenital cataracts, muscular hypotonia, areflexia, mental retardation, maladaptive behavior, renal tubular dysfunction, vitamin-D-resistant rickets, and scoliosis.	Vitamin D	231-240	OCRL inositol polyphosphate-5-phosphatase	Homo sapiens	33-37
10609555-6	2000	The expression of the three vitamin D-regulated genes calbindin-D28k, 1,25-dihydroxyvitamin D3-24-hydroxylase (24-OHase), and vitamin D receptor (VDR) were quantified in rat kidney homogenates by real-time reverse transcription-polymerase chain reaction.	Vitamin D	28-37	vitamin D receptor	Rattus norvegicus	126-144
10609555-6	2000	The expression of the three vitamin D-regulated genes calbindin-D28k, 1,25-dihydroxyvitamin D3-24-hydroxylase (24-OHase), and vitamin D receptor (VDR) were quantified in rat kidney homogenates by real-time reverse transcription-polymerase chain reaction.	Vitamin D	28-37	vitamin D receptor	Rattus norvegicus	146-149
10427145-5	1999	We report here that the vitamin D analogue EB1089 interferes with the IGF-IR signaling pathway by attenuating IGF-I-induced tyrosine phosphorylation of IRS-1, and to a lesser extent, IRS-2.	Vitamin D	24-33	insulin receptor substrate 1	Homo sapiens	152-157
10427145-5	1999	We report here that the vitamin D analogue EB1089 interferes with the IGF-IR signaling pathway by attenuating IGF-I-induced tyrosine phosphorylation of IRS-1, and to a lesser extent, IRS-2.	Vitamin D	24-33	insulin receptor substrate 2	Homo sapiens	183-188
10460470-1	1999	Vitamin D through its receptor (VDR) plays a major role in bone mineral metabolism.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	32-35
10419474-9	1999	Our study further showed that after all-trans-retinoic acid priming, AML2 expression could be augmented by vitamin D(3).	Vitamin D	107-116	RUNX family transcription factor 3	Homo sapiens	69-73
10409630-3	1999	Cell proliferation was significantly inhibited by the vitamin D analog 22-oxa-1,25-dihydroxyvitamin D(3) (22-oxacalcitriol; OCT) rather than by 1,25-dihydroxyvitamin D(3) (1, 25(OH)(2)D(3)) in a dose-dependent manner.	Vitamin D	54-63	plexin A2	Homo sapiens	124-127
10409630-9	1999	These results suggest that the vitamin D analog OCT induces smooth muscle phenotypic alterations and that this phenomenon was mediated through the induction of RII in cultured mesangial cells.	Vitamin D	31-40	plexin A2	Homo sapiens	48-51
10510732-3	1999	Relative to the limits of normalcy, fasting serum levels of gastrin were low, but normal for calcium, phosphorus, parathyroid hormone, calcitonin and vitamin D, while the level of total alkaline phosphatase was elevated; fasting urine pH and calcium were low, while phosphorus and net acid were high.	Vitamin D	150-159	gastrin	Homo sapiens	60-67
10433180-3	1999	The aim of this observational study was to determine whether vitamin D and calcium dysregulation contribute to the development of follicular arrest in women with PCO, resulting in reproductive and menstrual dysfunction.	Vitamin D	61-70	PCOS1	Homo sapiens	162-165
10052453-5	1999	Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.	Vitamin D	92-101	low density lipoprotein receptor-related protein 2	Mus musculus	0-7
9891040-7	1999	Such selective interaction of coactivators with VDR may specify the array of biological actions of a vitamin D analog like OCT, possibly through activating a particular set of target gene promoters.	Vitamin D	101-110	plexin A2	Homo sapiens	123-126
10609868-1	1999	Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR).	Vitamin D	24-33	retinoic acid receptor alpha	Homo sapiens	253-275
10609868-1	1999	Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR).	Vitamin D	24-33	retinoic acid receptor alpha	Homo sapiens	277-280
9893164-0	1999	Antitumor effect of vitamin D-binding protein-derived macrophage activating factor on Ehrlich ascites tumor-bearing mice.	Vitamin D	20-29	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	54-82
9768646-0	1998	A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets.	Vitamin D	52-61	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	2-6
9720659-4	1998	The purpose of our study was to determine the relationship between beta2m and vitamin D status in post-menopausal women.	Vitamin D	78-87	beta-2-microglobulin	Homo sapiens	67-73
9513092-0	1998	Growth inhibition of both MCF-7 and Hs578T human breast cancer cell lines by vitamin D analogues is associated with increased expression of insulin-like growth factor binding protein-3.	Vitamin D	77-86	insulin like growth factor binding protein 3	Homo sapiens	140-184
9513092-2	1998	Both vitamin D analogues inhibited IGF-1 stimulated growth of MCF-7 cells and enhanced the production of IGFBP-3 as determined by Western-ligand blotting.	Vitamin D	5-14	insulin like growth factor binding protein 3	Homo sapiens	105-112
9513092-7	1998	These findings suggest a role for IGFBP-3 in the growth inhibitory effects of vitamin D analogues.	Vitamin D	78-87	insulin like growth factor binding protein 3	Homo sapiens	34-41
9701451-10	1998	It is also implied that synthetic retinoids and vitamin D derivatives will provide very useful means to control distinct targets--TM and TF genes--at the level of transcription.	Vitamin D	48-57	coagulation factor III, tissue factor	Homo sapiens	137-139
9211344-1	1997	The biological action of calcitriol is mostly mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of target genes.	Vitamin D	117-126	vitamin D receptor	Rattus norvegicus	107-110
9204985-4	1997	In contrast, induction of leukaemic cell differentiation with 1 ng/ml GM-CSF after 96 h was less effective when compared with the vitamin D derivatives used individually.	Vitamin D	130-139	colony stimulating factor 2	Homo sapiens	70-76
9204985-8	1997	These co-operative effects may occur as a consequence of molecular events which involve the transcription by vitamin D receptors (VDR) of genes required for the responsiveness of immature cells to factors such as GM-CSF, and place these and other related vitamin D analogues as potential therapeutic agents in the treatment of leukaemia.	Vitamin D	109-118	colony stimulating factor 2	Homo sapiens	213-219
9207192-1	1997	In addition to suppressing prostate cell growth, vitamin D also up-regulates the expression of androgen receptor (AR) and prostate-specific antigen (PSA).	Vitamin D	49-58	kallikrein related peptidase 3	Homo sapiens	122-153
9013769-0	1997	The N-terminal domain of transcription factor IIB is required for direct interaction with the vitamin D receptor and participates in vitamin D-mediated transcription.	Vitamin D	94-103	cilia and flagella associated protein 20	Homo sapiens	25-49
9328147-0	1997	Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines.	Vitamin D	0-9	interferon alpha inducible protein 27	Homo sapiens	40-43
9328147-5	1997	In conclusion, vitamin D analogues up-regulate p21 and p27 as an early event, which in turn could block the G1/S transition and induce growth inhibition in responsive cells.	Vitamin D	15-24	interferon alpha inducible protein 27	Homo sapiens	55-58
8940000-7	1996	These results demonstrate that VDRE-1 is a stronger mediator of vitamin D function than VDRE-2 due to the presence of the accessory element -169/-155 located adjacent to VDRE-1, although VDRE-2 exhibits a smaller dissociation constant for the vitamin D receptor-retinoid X receptor complex than VDRE-1.	Vitamin D	64-73	vitamin D receptor	Rattus norvegicus	243-261
8913867-4	1996	To determine whether the 1 beta-hydroxymethyl analogs induced a VDR-mediated transcription, we tested the induction of reporter gene expression through the osteocalcin vitamin D response element (VDRE) in ROS 17/2.8 cells and the induction of binding activity of VDR to VDRE in COS-1 cells.	Vitamin D	168-177	vitamin D receptor	Rattus norvegicus	64-67
8913867-4	1996	To determine whether the 1 beta-hydroxymethyl analogs induced a VDR-mediated transcription, we tested the induction of reporter gene expression through the osteocalcin vitamin D response element (VDRE) in ROS 17/2.8 cells and the induction of binding activity of VDR to VDRE in COS-1 cells.	Vitamin D	168-177	vitamin D receptor	Rattus norvegicus	196-199
8914020-1	1996	The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes.	Vitamin D	107-116	vitamin D receptor	Rattus norvegicus	97-100
8754789-1	1996	The aim of this study was to investigate the expression pattern of 1, 25-dihydroxyvitamin D3 receptor (VDR) and vitamin D-responsive gene expression during the steps of hard tissue formation in oro-facial development.	Vitamin D	82-91	vitamin D receptor	Rattus norvegicus	103-106
8622645-6	1996	Although VDR can bind as a homodimer to the osteopontin gene vitamin D response element, we find that a RXR-VDR heterodimer must be the transactivating species from the element in vivo, since RXR enhances and 9-cis RA and other RXR-specific ligands attenuate this induction.	Vitamin D	61-70	secreted phosphoprotein 1	Homo sapiens	44-55
8860739-1	1996	Calbindin-D, a vitamin D-dependent calcium-binding protein of 28 kD, is found predominantly in the distal tubules of the kidney and central nervous system tissues in humans.	Vitamin D	15-24	calbindin 1	Homo sapiens	0-9
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	FBJ osteosarcoma oncogene	Mus musculus	156-161
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	FBJ osteosarcoma oncogene	Mus musculus	184-189
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	FBJ osteosarcoma oncogene	Mus musculus	204-209
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	FBJ osteosarcoma oncogene	Mus musculus	270-275
7577156-14	1995	The genomic action of vitamin D, in vitro, resulted in the synthesis of nuclear VDR and calbindins-D.	Vitamin D	22-31	vitamin D receptor	Rattus norvegicus	80-83
7602380-2	1995	Previous studies have shown that in enterocytes this Ca(2+)-pumping ATPase could be stimulated by vitamin D-dependent Ca(2+)-binding protein, calbindin-D9k, in ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA)-free solutions.	Vitamin D	98-107	S100 calcium binding protein G	Rattus norvegicus	142-155
7579059-2	1995	The effect of the vitamin D metabolite on the proliferative responses of macrophages to the cytokine colony-stimulating factor-1 (CSF-1) has been studied.	Vitamin D	18-27	colony stimulating factor 1	Homo sapiens	101-128
7579059-2	1995	The effect of the vitamin D metabolite on the proliferative responses of macrophages to the cytokine colony-stimulating factor-1 (CSF-1) has been studied.	Vitamin D	18-27	colony stimulating factor 1	Homo sapiens	130-135
7651755-1	1995	The aim of this study was to investigate whether 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D, regulates the expression of rat placental calbindin-D9K mRNA.	Vitamin D	63-72	S100 calcium binding protein G	Rattus norvegicus	167-180
21153145-2	1995	Here we demonstrate that the vitamin D analogs, 25(OH)(2)-16-ene-23-yne-D(3) and 1alpha, 24S-(OH)(2)-22-en-26, 27-dehydro-vitamin D(3), which have been shown by others to bind to the intracellular vitamin D receptor (VDR), have similar effects to 1, 25(OH)(2)D(3) in increasing ALPA of IEC-6 cells.	Vitamin D	29-38	vitamin D receptor	Rattus norvegicus	197-215
21153145-2	1995	Here we demonstrate that the vitamin D analogs, 25(OH)(2)-16-ene-23-yne-D(3) and 1alpha, 24S-(OH)(2)-22-en-26, 27-dehydro-vitamin D(3), which have been shown by others to bind to the intracellular vitamin D receptor (VDR), have similar effects to 1, 25(OH)(2)D(3) in increasing ALPA of IEC-6 cells.	Vitamin D	29-38	vitamin D receptor	Rattus norvegicus	217-220
21153145-3	1995	A third vitamin D analog, 25-(OH)-16-ene-23-yne-D(3) (AT), which activates membrane 1,25(OH)(2)D(3) effects, but binds poorly to the intracellular VDR, did not stimulate ALPA of IEC-6 cells.	Vitamin D	8-17	vitamin D receptor	Rattus norvegicus	147-150
7819220-0	1995	Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene expression.	Vitamin D	42-51	vitamin D receptor	Rattus norvegicus	62-65
8538212-7	1995	In normal mice, and in mice carrying a targeted apc gene mutation, we recently increased colonic polypoid hyperplasias by a Western-style diet containing low calcium and vitamin D.	Vitamin D	170-179	APC, WNT signaling pathway regulator	Mus musculus	48-51
7988455-11	1994	These results indicate that 1,25-(OH)2D3 stimulates the synthesis and release of hPL by a mechanism involving hPL gene transcription and support a role for vitamin D and the VDR in placental function.	Vitamin D	156-165	galectin 1	Homo sapiens	81-84
7836898-0	1994	A vitamin D analogue KH 1060 activates the protein kinase C-c-fos signalling pathway to stimulate epidermal proliferation in murine skin.	Vitamin D	2-11	FBJ osteosarcoma oncogene	Mus musculus	60-65
8267583-4	1993	Moreover, since rat liver nuclear extract contains retinoid X receptors and possibly other auxiliary factors capable of forming heterodimers with hVDR that in turn associate with vitamin D responsive elements, we hypothesize that like DNA binding, 1,25(OH)2D3 binding to hVDR requires the cooperation of a co-receptor or some uncharacterized receptor activating/stabilizing factor.	Vitamin D	179-188	vitamin D receptor	Homo sapiens	146-150
8514854-0	1993	A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo.	Vitamin D	2-11	parathyroid hormone-like hormone	Rattus norvegicus	39-74
8514854-7	1993	Additionally, reduced levels of tumor PTHRP mRNA and of plasma iPTHRP were observed compared with controls in both vitamin D- and EB1089-treated rats.	Vitamin D	115-124	parathyroid hormone-like hormone	Rattus norvegicus	38-43
8514854-10	1993	These studies demonstrate that 1,25(OH)2D3 and a low calcemic vitamin D analogue are potent inhibitors of PTHRP production in vivo.	Vitamin D	62-71	parathyroid hormone-like hormone	Rattus norvegicus	106-111
8482081-0	1993	Detection of the 9-kDa vitamin D-dependent calbindin gene in a fruit bat (Rousettus aegyptiacus) fibroblast cell line.	Vitamin D	23-32	calbindin 1	Mus musculus	43-52
8382345-3	1993	We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha).	Vitamin D	34-43	vitamin D receptor	Homo sapiens	95-113
8382345-3	1993	We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha).	Vitamin D	34-43	vitamin D receptor	Homo sapiens	115-118
8382345-3	1993	We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha).	Vitamin D	34-43	vitamin D receptor	Homo sapiens	148-151
8382345-3	1993	We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha).	Vitamin D	34-43	retinoid X receptor alpha	Homo sapiens	160-185
8382345-3	1993	We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha).	Vitamin D	34-43	retinoid X receptor alpha	Homo sapiens	187-196
8382345-4	1993	The motif GGGTGA arranged as a direct repeat with a spacing of six nucleotides or as a palindrome without spacing, or as an inverted palindrome with a 12-nucleotide spacing, confers vitamin D inducibility mediated by VDR alone.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	217-220
8381969-9	1993	Such protein-DNA interactions at the VDRE are consistent with repression of competency for vitamin D-mediated transcriptional enhancement in proliferating osteoblasts expressing high levels of Fos and Jun.	Vitamin D	91-100	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	193-196
1442201-12	1992	Serum calcium and phosphorus levels were lower and alkaline phosphatase levels were higher in VDP- hosts compared with normal animals or those treated with vitamin D metabolites.	Vitamin D	156-165	USO1 vesicle transport factor	Rattus norvegicus	94-97
1312760-1	1992	The mechanisms by which glucocorticoids (GC) inhibit some actions of vitamin D [1,25-(OH)2D3] are not well understood, but there is growing evidence that GC alter vitamin D receptor (VDR) number.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	183-186
1300345-4	1992	It is concluded that PTH, probably in concomitant with other factors such as vitamin D or parathyroid hypertensive factor, has a permissive effect in the development and the maintenance of hypertension in GHR.	Vitamin D	77-86	growth hormone receptor	Homo sapiens	205-208
1999168-12	1991	In contrast, MGP expression was stimulated in the chronic vitamin D-treated cultures similar to acute treatments.	Vitamin D	58-67	matrix Gla protein	Rattus norvegicus	13-16
2065866-0	1991	Developmental control over vitamin-D-induced calbindin gene expression during early differentiation of chicken jejunal enterocytes.	Vitamin D	27-36	calbindin 1	Gallus gallus	45-54
2065866-1	1991	In situ hybridization and immunocytochemical techniques have been used to examine the distribution of vitamin-D-induced calbindin mRNA and calbindin protein in enterocytes lining the crypts and villi of chicken small intestine.	Vitamin D	102-111	calbindin 1	Gallus gallus	120-129
1846564-3	1991	We used human osteosarcoma cells (MG-63) and measured hVDR and GR mRNA levels after androgen, estrogen, glucocorticoid, progesterone, thyroid hormone, vitamin A and vitamin D treatments.	Vitamin D	165-174	vitamin D receptor	Homo sapiens	54-65
1900844-3	1991	Evidence is presented for a model which postulates that genes transcribed post-proliferatively are suppressed during cell growth by binding of the Fos/Jun protein complex to AP-1 promoter sites associated with vitamin D responsive elements of several genes encoding osteoblast phenotype markers (Type I collagen, alkaline phosphatase, osteocalcin).	Vitamin D	210-219	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-150
2124710-0	1990	Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.	Vitamin D	42-51	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-28
2124710-0	1990	Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.	Vitamin D	42-51	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-92
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-61
2124710-3	1990	We present evidence that AP-1 (HeLa cell-activating protein 1) sites residing within two promoter elements of the osteocalcin gene bind the Fos-Jun protein complex: the osteocalcin box (OC box; nucleotides -99 to -76), which contains a CCAAT motif as a central element and influences tissue-specific basal levels of osteocalcin gene transcription, and the vitamin D-responsive element (VDRE; nucleotides -462 to -440), which mediates enhancement of osteocalcin gene transcription.	Vitamin D	356-365	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-143
2124710-7	1990	These results support a model in which coordinate occupancy of the AP-1 sites in the VDRE and OC box in proliferating osteoblasts may suppress both basal level and vitamin D-enhanced osteocalcin gene transcription as well as transcription of other genes associated with osteoblast differentiation--a phenomenon we describe as phenotype suppression.	Vitamin D	164-173	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-71
2241170-14	1990	The present results demonstrate that intestinal tissue levels of calbindin D and its mRNA respond similarly to vitamin D repletion and dietary Ca restriction as well as the combination of these stimuli.	Vitamin D	111-120	calbindin 1	Gallus gallus	65-74
2344392-3	1990	The intestinal concentration of calbindin was increased 30-fold by 1,25-(OH)2D3 in chicks treated with oestradiol and fed a vitamin D-deficient diet.	Vitamin D	124-133	calbindin 1	Gallus gallus	32-41
2155346-2	1990	Vitamin D or its metabolites are dissolved in 100 microliters methanol and 10 M HC1 in 2-butanol is used as the reagent for isomerization.	Vitamin D	0-9	CYCS pseudogene 39	Homo sapiens	80-83
33798678-2	2021	Transcriptional regulation of REN has been linked to enhancer-promoter crosstalk, cAMP response element-binding protein (CREB), the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and a less well-characterized intronic silencer element.	Vitamin D	153-162	cAMP responsive element binding protein 1	Homo sapiens	82-119
33798678-2	2021	Transcriptional regulation of REN has been linked to enhancer-promoter crosstalk, cAMP response element-binding protein (CREB), the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and a less well-characterized intronic silencer element.	Vitamin D	153-162	cAMP responsive element binding protein 1	Homo sapiens	121-125
33771629-0	2021	PARACOCCIDIOIDES brasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro.	Vitamin D	77-86	interleukin 15	Homo sapiens	65-70
33819635-0	2021	Authors" reply: Vitamin D sufficiency and COVID-19: is vitamin D binding protein (and its polymorphism) the missing link?	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	55-80
33801744-1	2021	Vitamin D deficiency has adverse effects on renal allograft outcomes, and polymorphisms of genes encoding vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) are defined to play a role in these conditions.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	133-137
33801744-1	2021	Vitamin D deficiency has adverse effects on renal allograft outcomes, and polymorphisms of genes encoding vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) are defined to play a role in these conditions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	143-161
33801744-1	2021	Vitamin D deficiency has adverse effects on renal allograft outcomes, and polymorphisms of genes encoding vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) are defined to play a role in these conditions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	163-166
33772215-0	2021	The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials.	Vitamin D	14-23	fibroblast growth factor 23	Homo sapiens	27-54
33810258-1	2021	BACKGROUND: Seven weeks of high-dose vitamin D treatment decreases intestinal IL17A and IFN-gamma mRNA expression in active Crohn"s disease (CD).	Vitamin D	37-46	interleukin 17A	Homo sapiens	78-83
34563663-0	2022	Vitamin D decreases pancreatic iron overload in type 2 diabetes through the NF-kappaB-DMT1 pathway.	Vitamin D	0-9	RoBo-1	Rattus norvegicus	86-90
34563663-5	2022	Moreover, vitamin D alleviated iron accumulation and apoptosis in pancreatic cells of ZDF rats, accompanied by lowered divalent metal transporter 1 (DMT1) expression.	Vitamin D	10-19	RoBo-1	Rattus norvegicus	119-147
34563663-5	2022	Moreover, vitamin D alleviated iron accumulation and apoptosis in pancreatic cells of ZDF rats, accompanied by lowered divalent metal transporter 1 (DMT1) expression.	Vitamin D	10-19	RoBo-1	Rattus norvegicus	149-153
34563663-9	2022	Our study showed that iron overload in pancreas may contribute to T2D pathogenesis and uncovered a potentially protective role for vitamin D on iron deposition of diabetic pancreas through NF-kappaB- DMT1 signaling.	Vitamin D	131-140	RoBo-1	Rattus norvegicus	200-204
34710560-0	2022	The effect of vitamin D supplementation on serum levels of fibroblast growth factor- 23: A systematic review and meta-analysis of randomized controlled trials.	Vitamin D	14-23	fibroblast growth factor 23	Homo sapiens	59-87
34710560-2	2022	This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to investigate the effect of vitamin D supplementation on serum levels of FGF-23.	Vitamin D	116-125	fibroblast growth factor 23	Homo sapiens	161-167
34710560-3	2022	PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched, from database inception to November 2020, for RCTs that evaluated the effects of native or active vitamin D supplementation on serum levels of FGF-23 in adults.	Vitamin D	174-183	fibroblast growth factor 23	Homo sapiens	219-225
34861286-16	2022	SIGNIFICANCE: Pirfenidone and vitamin D demonstrated a viable approach to suppress the nephrotoxicity initiated by doxorubicin through inhibiting the JNK1 and MCP-1 pathways.	Vitamin D	30-39	mitogen-activated protein kinase 8	Mus musculus	150-154
34764490-0	2022	Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells.	Vitamin D	10-19	negative elongation factor complex member C/D	Homo sapiens	72-75
34597852-6	2022	Low vitamin D levels were associated with a high CD8/Treg ratio; increased serum levels and T-cell production of proinflammatory cytokines; and a gene expression signature of unrestrained T-cell proliferation and epigenetic modulation through the PRC2/EZH2 complex.	Vitamin D	4-13	CD8a molecule	Homo sapiens	49-52
34534339-4	2021	Uptake of 25(OH)D3 led to a significant upregulation of vitamin D metabolizing CYP24A1 mRNA levels, indicating that kidney organoids possess a feedback mechanism to control active vitamin D (1,25(OH)2D3) levels.	Vitamin D	56-65	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	79-86
34534339-4	2021	Uptake of 25(OH)D3 led to a significant upregulation of vitamin D metabolizing CYP24A1 mRNA levels, indicating that kidney organoids possess a feedback mechanism to control active vitamin D (1,25(OH)2D3) levels.	Vitamin D	180-189	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	79-86
34886758-7	2021	The immune function of vitamin D is explained in part by the presence of its receptor (VDR) and its activating enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) in immune cells.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	87-90
34977255-1	2021	Vitamin D is an important hormone involved in various physiologic processes, and its activity is linked to binding with vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	120-138
34977255-1	2021	Vitamin D is an important hormone involved in various physiologic processes, and its activity is linked to binding with vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	140-143
34977255-2	2021	Genetic polymorphisms in the VDR gene could modulate the expression or function of the receptor and, consequently, alter the effects of vitamin D.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	29-32
34977255-3	2021	Variants in VDR gene have been associated with susceptibility to many illnesses sensitive to vitamin D administration and to autoimmune disorders, but no data are available regarding autoimmune connective tissue diseases in Italian population.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	12-15
34919268-3	2022	This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency.	Vitamin D	167-176	vitamin D receptor	Homo sapiens	57-60
34343413-6	2021	RESULTS: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data.	Vitamin D	183-192	vitamin D receptor	Homo sapiens	129-147
34460994-15	2021	Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level.	Vitamin D	153-162	interleukin 17A	Mus musculus	46-51
34944566-6	2021	The review presents the molecular genetic mechanisms of the effect of vitamin D on adipose tissue resident T lymphocytes and the characteristics of vitamin D receptor expression, and analyzes the phenotypic and functional characteristics of potentially pathogenic T lymphocytes in relation to the development of obesity and its associated complications.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	148-166
34950833-1	2021	Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements.	Vitamin D	48-57	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	107-125
34950833-1	2021	Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements.	Vitamin D	48-57	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-130
34950833-1	2021	Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements.	Vitamin D	216-225	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	107-125
34950833-1	2021	Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements.	Vitamin D	216-225	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-130
34833489-13	2021	Real-time polymerase chain reaction results demonstrated that the mRNA expression levels of RUNX2, OCN, and COL1A1 were significantly increased when vitamin D was added to the culture.	Vitamin D	149-158	collagen type I alpha 1 chain	Homo sapiens	108-114
34950829-0	2021	Vitamin D Actions: The Lung Is a Major Target for Vitamin D, FGF23, and Klotho.	Vitamin D	0-9	klotho	Homo sapiens	72-78
34950829-3	2021	The expression of the vitamin D receptor by different cell types in the lung and the fact that those cells respond to vitamin D or can locally produce vitamin D indicate that the lung represents a target for vitamin D actions.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	22-40
34950829-3	2021	The expression of the vitamin D receptor by different cell types in the lung and the fact that those cells respond to vitamin D or can locally produce vitamin D indicate that the lung represents a target for vitamin D actions.	Vitamin D	208-217	vitamin D receptor	Homo sapiens	22-40
34950832-1	2021	1,25(OH)2D3, the biologically active form of vitamin D3, is a major regulator of mineral and bone homeostasis and exerts its actions through binding to the vitamin D receptor (VDR), a ligand-activated transcription factor that can directly modulate gene expression in vitamin D-target tissues such as the intestine, kidney, and bone.	Vitamin D	268-277	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	156-174
34950832-1	2021	1,25(OH)2D3, the biologically active form of vitamin D3, is a major regulator of mineral and bone homeostasis and exerts its actions through binding to the vitamin D receptor (VDR), a ligand-activated transcription factor that can directly modulate gene expression in vitamin D-target tissues such as the intestine, kidney, and bone.	Vitamin D	268-277	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	176-179
34830234-3	2021	Accordingly, these techniques have established that the vitamin D hormone modulates sets of cell-type specific genes via an initial action that involves rapid binding of the VDR-ligand complex to multiple enhancer elements at open chromatin sites that drive the expression of individual genes.	Vitamin D	56-65	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	174-177
34851599-3	2021	In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma).	Vitamin D	33-42	vitamin D receptor	Homo sapiens	152-170
34851599-3	2021	In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma).	Vitamin D	33-42	vitamin D receptor	Homo sapiens	172-175
34851599-3	2021	In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma).	Vitamin D	33-42	RAR related orphan receptor A	Homo sapiens	219-256
34956480-1	2021	OBJECTIVE: To explore the molecular mechanism underlying the effect of maternal vitamin D (Vit D) supplementation before pregnancy in advanced maternal age (AMA) mice on the offspring"s cognitive function.	Vitamin D	80-89	vitrin	Mus musculus	91-94
34617343-2	2021	It has also been reported that vitamin D deficiency may play a role in this, possibly because of the multi-gene regulatory function of the vitamin D receptor.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	139-157
34617343-8	2021	All the included studies found that supplementation of vitamin D (D2 and D3 ), regardless of dosage, increased 25(OH)D levels compared to a placebo.	Vitamin D	55-64	immunoglobulin heavy diversity 2-15	Homo sapiens	66-75
34562689-8	2021	RESULTS: Age, gender, Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score III (SAPS3) and season of admission were identified by the LASSO regression analysis as significant predictors of vitamin D severe deficiency at ICU admission.	Vitamin D	214-223	protein phosphatase 6 regulatory subunit 3	Homo sapiens	105-110
34723751-0	2021	Vitamin D binding protein and its polymorphisms may explain the link between vitamin D deficiency and COVID-19.	Vitamin D	77-86	GC vitamin D binding protein	Homo sapiens	0-25
34950826-5	2021	The requirement for a vitamin D receptor for the photoprotective actions of 1,25(OH)2D3 and of naturally occurring CYP11A1-derived vitamin D-related compounds may explain why mice lacking the vitamin D receptor in skin are more susceptible to UV-induced skin cancers, whereas mice lacking the 1alpha-hydroxylase and thus unable to make 1,25(OH)2D3 are not more susceptible.	Vitamin D	131-140	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	22-40
34950826-5	2021	The requirement for a vitamin D receptor for the photoprotective actions of 1,25(OH)2D3 and of naturally occurring CYP11A1-derived vitamin D-related compounds may explain why mice lacking the vitamin D receptor in skin are more susceptible to UV-induced skin cancers, whereas mice lacking the 1alpha-hydroxylase and thus unable to make 1,25(OH)2D3 are not more susceptible.	Vitamin D	131-140	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	192-210
34664810-4	2021	Vitamin D (Vit D) is the main supplementary factor for the immune system.	Vitamin D	0-9	vitrin	Mus musculus	11-14
34680413-9	2021	This suggests combined benefits of butyrate and active vitamin D on Salmonella colitis through VDR-mediated antibacterial and anti-inflammatory responses.	Vitamin D	55-64	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	95-98
34551710-11	2021	VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039).	Vitamin D	46-55	vitamin D receptor	Homo sapiens	0-3
34584434-2	2021	Therefore, the relationship between the pathogenesis of type 1 diabetes and the genetic variants of Vitamin D receptor, which is involved in the activity of Vitamin D, was studied extensively in different populations.	Vitamin D	157-166	vitamin D receptor	Homo sapiens	100-118
34621292-11	2021	GWAS analysis identified rs4588, a missense variant in the group-specific component (GC) gene encoding vitamin D binding protein (VDBP), and its defining haplotype, as a risk factor for low antenatal (Beta=-8.56/T-allele, p=1.0x10-9) and cord blood vitamin D (Beta=-3.22/T-allele, p=1.0x10-8) in all three ethnicities.	Vitamin D	249-258	GC vitamin D binding protein	Homo sapiens	103-128
34572935-4	2021	Although there were no significant differences, the risk of relapse was lower in the vitamin D group than in the placebo group in the higher half of CD45RO+ memory T cells (8.9% vs. 19.2%), and of CD8+ cytotoxic T cells (11.3% vs. 22.5%).	Vitamin D	85-94	protein tyrosine phosphatase receptor type C	Homo sapiens	149-155
34421816-1	2021	Background: It has been demonstrated that vitamin D receptor (VDR), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver disease (NAFLD) by regulating VD level and its biological effects.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	42-60
34421816-1	2021	Background: It has been demonstrated that vitamin D receptor (VDR), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver disease (NAFLD) by regulating VD level and its biological effects.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	62-65
34159811-2	2021	Previous studies conducted in an intestinal epithelial-specific vitamin D receptor (VDR) knockout model suggest that a lack of vitamin D signaling causes a reduction in intestinal autophagy.	Vitamin D	127-136	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	64-82
34159811-2	2021	Previous studies conducted in an intestinal epithelial-specific vitamin D receptor (VDR) knockout model suggest that a lack of vitamin D signaling causes a reduction in intestinal autophagy.	Vitamin D	127-136	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	84-87
34159811-6	2021	However, Paneth cells of vitamin D deficient mice were morphologically abnormal and had an accumulation of the autophagy adaptor protein p62 which was not present in the total crypt epithelium.	Vitamin D	25-34	nucleoporin 62	Mus musculus	137-140
34246812-7	2021	Gene expression profiles for other known fibroblast immune mediators (SAA3 and CCL20) did not show significant differences between haplotypes but NOS2 gene expression was significantly elevated in response to vitamin D, even above the level detected in response to both TLR ligands.	Vitamin D	209-218	nitric oxide synthase 2	Bos taurus	146-150
34389701-0	2021	The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes.	Vitamin D	30-39	sirtuin 1	Homo sapiens	121-137
34389701-2	2021	This study aimed to evaluate the effects of daily intake of vitamin D-fortified yogurt drink, either with or without added calcium, on serum adiponectin, sirtuins (SIRT)1 and 6.	Vitamin D	60-69	sirtuin 1	Homo sapiens	154-176
34389701-11	2021	CONCLUSIONS: Daily consumption of vitamin D-fortified yogurt drink for 12 weeks resulted in an increase in circulating concentrations of SIRT1 and SIRT6 in T2D subjects and D+Ca-fortified yogurt drink was more in favor of SIRT6 increment.	Vitamin D	34-43	sirtuin 1	Homo sapiens	137-142
34315477-10	2021	However, genetically regulated 25(OH)D deficiency due to vitamin D synthesis gene (DHCR7) may influence the risk of T2D.	Vitamin D	57-66	7-dehydrocholesterol reductase	Homo sapiens	83-88
34296353-1	2022	Fibroblast growth factor 23 (FGF-23), a hormone mainly secreted by osteocytes and osteoblasts, regulates phosphate and vitamin D levels.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	0-27
34296353-1	2022	Fibroblast growth factor 23 (FGF-23), a hormone mainly secreted by osteocytes and osteoblasts, regulates phosphate and vitamin D levels.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	29-35
34210242-8	2021	CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1.	Vitamin D	12-21	brain derived neurotrophic factor	Homo sapiens	161-165
34210242-8	2021	CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1.	Vitamin D	12-21	sirtuin 1	Homo sapiens	185-190
34111685-7	2021	The opposite, expression of CYP24A1 (vitamin D degrading enzyme), was significantly higher in IgAN-P in comparison with controls (p = 0.0003).	Vitamin D	37-46	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	28-35
34265491-1	2021	AIMS: Current study aimed to evaluate the effect of vitamin D supplementation on flow-mediated dilatation (FMD), oxidized LDL (oxLDL) and intracellular adhesion molecule 1 (ICAM1) in type 2 diabetic patients with hypertension.	Vitamin D	52-61	intercellular adhesion molecule 1	Homo sapiens	138-171
34265491-1	2021	AIMS: Current study aimed to evaluate the effect of vitamin D supplementation on flow-mediated dilatation (FMD), oxidized LDL (oxLDL) and intracellular adhesion molecule 1 (ICAM1) in type 2 diabetic patients with hypertension.	Vitamin D	52-61	intercellular adhesion molecule 1	Homo sapiens	173-178
34265491-6	2021	In the vitamin D group, oxLDL and ICAM1 significantly decreased and FMD increased significantly in both groups (p < 0.001).	Vitamin D	7-16	intercellular adhesion molecule 1	Homo sapiens	34-39
34265491-7	2021	The level of oxLDL (p = 0.017) and ICAM1 (p < 0.001) were significantly lower in the vitamin D group than the placebo group and FMD (p < 0.001) was significantly higher in the vitamin D group.	Vitamin D	85-94	intercellular adhesion molecule 1	Homo sapiens	35-40
34265491-7	2021	The level of oxLDL (p = 0.017) and ICAM1 (p < 0.001) were significantly lower in the vitamin D group than the placebo group and FMD (p < 0.001) was significantly higher in the vitamin D group.	Vitamin D	176-185	intercellular adhesion molecule 1	Homo sapiens	35-40
34265491-8	2021	CONCLUSIONS: Vitamin D supplementation of 2000 IU/d for 12 weeks can improve endothelial function and decrease ICAM1 and oxLDL in type 2 diabetic patients with hypertension.	Vitamin D	13-22	intercellular adhesion molecule 1	Homo sapiens	111-116
34249156-15	2021	The NF is a bioavailable source of the biologically active metabolite of vitamin D, i.e. 1,25-dihydroxyvitamin D.	Vitamin D	73-82	neurofascin	Homo sapiens	4-6
34097028-6	2021	A Vitamin D panel revealed a severely elevated parathyroid hormone level.	Vitamin D	2-11	parathyroid hormone	Felis catus	47-66
34759139-2	2021	The serum 25-hydroxyvitamin D (25(OH)D) level was 13.4 +- 0.8 ng / mL and it markedly increased to 29.6 +- 0.9 ng / mL after daily 1000-IU vitamin D-fortified milk intake for 6 months.	Vitamin D	139-148	thrombopoietin	Mus musculus	116-118
34980721-1	2021	CYP24A1 regulates serum vitamin D (VD) levels by inactivating 25(OH)2D3, which is the precursor of the active form of VD (1alpha,25(OH)2D3), and CYP24A1 expression is controlled by multiple calcemic factors such as 1alpha,25(OH)2D3, calcium, and phosphate.	Vitamin D	24-33	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
34980721-1	2021	CYP24A1 regulates serum vitamin D (VD) levels by inactivating 25(OH)2D3, which is the precursor of the active form of VD (1alpha,25(OH)2D3), and CYP24A1 expression is controlled by multiple calcemic factors such as 1alpha,25(OH)2D3, calcium, and phosphate.	Vitamin D	24-33	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-152
34139712-0	2021	Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study).	Vitamin D	64-73	vitamin D receptor	Homo sapiens	15-33
8216267-0	1993	RXR-independent action of the receptors for thyroid hormone, retinoid acid and vitamin D on inverted palindromes.	Vitamin D	79-88	retinoid X receptor alpha	Homo sapiens	0-3
8395017-1	1993	The vitamin D receptor (VDR) binds the vitamin D-responsive element (VDRE) as a heterodimer with an unidentified receptor auxiliary factor (RAF) present in mammalian cell nuclear extracts.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
34139712-1	2021	BACKGROUND/AIM: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	248-266
34139712-1	2021	BACKGROUND/AIM: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	268-271
8392065-10	1993	Mutation of serine 51 to glycine (S51G) or to aspartic acid (S51D), as well as altering the basic residues flanking serine 51, abolished the interaction of hVDR with the vitamin D-responsive element (VDRE) as monitored by gel mobility shift analysis.	Vitamin D	170-179	vitamin D receptor	Homo sapiens	156-160
34139712-6	2021	CONCLUSIONS: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	65-68
34139712-6	2021	CONCLUSIONS: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine.	Vitamin D	167-176	vitamin D receptor	Homo sapiens	65-68
34387450-1	2021	OBJECTIVE: To evaluate the association polymorphisms in genes coding for enzymes involved in vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) with the risk of multiple sclerosis (MS).	Vitamin D	93-102	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	137-144
8381251-6	1993	We now speculate that the discrepancy in VDR quantitation by binding and immunoblot analysis in the B95-8 New World primate cell line results from the presence of an intracellular, vitamin D metabolite binding moiety in this cell line that competes with the VDR for metabolite binding.	Vitamin D	181-190	vitamin D3 receptor	Callithrix jacchus	41-44
8381251-6	1993	We now speculate that the discrepancy in VDR quantitation by binding and immunoblot analysis in the B95-8 New World primate cell line results from the presence of an intracellular, vitamin D metabolite binding moiety in this cell line that competes with the VDR for metabolite binding.	Vitamin D	181-190	vitamin D3 receptor	Callithrix jacchus	258-261
34522720-1	2021	Vitamin D receptor (VDR) executes the main biological functions of its ligand vitamin D.	Vitamin D	78-87	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
1335319-6	1992	These results indicate that the vitamin D-resistance in Hyp mice is not caused by hypophosphatemia, per se, and may result from a fundamental molecular defect in vitamin D action at the intestine which could be related to ineffective up-regulation of VDR mRNA by 1,25(OH)2D3.	Vitamin D	32-41	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	251-254
34522720-1	2021	Vitamin D receptor (VDR) executes the main biological functions of its ligand vitamin D.	Vitamin D	78-87	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
34522720-2	2021	VDR/vitamin D plays critical roles in regulating host immunity, maintaining barrier functions, and shaping gut microbiome.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
34291138-11	2021	Thus, monitoring the methylation status of specific VDR promoter region might help stratify the high-risk individuals who could potentially benefit from vitamin D dietary supplementation.	Vitamin D	153-162	vitamin D receptor	Homo sapiens	52-55
1337119-5	1992	VDR complexes recognize vitamin D responsive element on DNA, two tandemly repeated hexanucleotide sequences separated by three base pairs.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	0-3
35595176-3	2022	The mechanisms that underpin the link between low 25(OH)D3 and sarcopenia are yet to be fully understood but several lines of evidence have highlighted the importance of both genomic and non-genomic effects of active vitamin D (1,25-dihydroxyvitamin D (1,25(OH)2D3)) and its nuclear vitamin D receptor (VDR), in skeletal muscle functioning.	Vitamin D	217-226	vitamin D receptor	Homo sapiens	283-301
1459360-8	1992	Previously it was suggested that inefficient translation to calbindin mRNA might take place in basal villus enterocytes 48 h after vitamin D injection.	Vitamin D	131-140	calbindin 1	Gallus gallus	60-69
35595176-3	2022	The mechanisms that underpin the link between low 25(OH)D3 and sarcopenia are yet to be fully understood but several lines of evidence have highlighted the importance of both genomic and non-genomic effects of active vitamin D (1,25-dihydroxyvitamin D (1,25(OH)2D3)) and its nuclear vitamin D receptor (VDR), in skeletal muscle functioning.	Vitamin D	217-226	vitamin D receptor	Homo sapiens	303-306
35490953-5	2022	Significant differences existed in the increase of CD4+ and CD8+ T cells based on vitamin D levels.	Vitamin D	82-91	CD8a molecule	Homo sapiens	60-63
1525046-0	1992	Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein.	Vitamin D	62-71	GC vitamin D binding protein	Homo sapiens	94-119
35490953-6	2022	Vitamin D sufficiency group had a significantly higher increase of CD4+ T cells during 6 months of anti-TB treatment and CD8+ T cells after 4 months of anti-TB treatment than the other groups.	Vitamin D	0-9	CD8a molecule	Homo sapiens	121-124
1297829-0	1992	Tissue-specific production of the third component of complement(C3) by vitamin D in bone.	Vitamin D	71-80	complement C3	Homo sapiens	53-66
35490953-8	2022	Conclusions Through null effects on sputum smear conversion, vitamin D may have a beneficial effect on the increase of CD4+ and CD8+ T cells during anti-TB treatment.	Vitamin D	61-70	CD8a molecule	Homo sapiens	128-131
35524469-0	2022	Modulatory effects of vitamin D on IL-33/ST2 immune axis in Guillain-Barre syndrome...Quo Vadis?	Vitamin D	22-31	ST2	Homo sapiens	41-44
35620310-11	2022	Moreover, linear regression analysis indicated that BDNF levels were inversely correlated with serum vitamin D levels.	Vitamin D	101-110	brain derived neurotrophic factor	Homo sapiens	52-56
1655763-6	1991	Recombinant hVDR generated a specific protein-DNA complex with a duplex oligomer containing a vitamin D-responsive element (VDRE) in gel mobility shift assays.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	12-16
35620310-12	2022	Furthermore, vitamin D supplementation significantly increased vitamin D serum levels and decreased BDNF serum levels in diabetic patients.	Vitamin D	13-22	brain derived neurotrophic factor	Homo sapiens	100-104
35607362-7	2022	We also observed that although the total daily PUFA dosage that exhibited beneficial effects was in the range of 0.7-2 g EPA and 0.4-0.8 g DHA daily, with an administration period of three weeks to four months, positive vitamin D-based supplementation effects were observed after administering doses of 2000 IU/day or 50,000 IU/week between 8 weeks and 24 months.	Vitamin D	220-229	pumilio RNA binding family member 3	Homo sapiens	47-51
1652893-1	1991	Vitamin D-dependent rickets type II is a hereditary disease resulting from a defective vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	87-105
1868452-0	1991	K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.	Vitamin D	109-118	KRAS proto-oncogene, GTPase	Rattus norvegicus	0-5
1868452-8	1991	These findings suggest that alterations in K-ras mutations may be one possible mechanism by which calcium and vitamin D status influence colonic carcinogenesis in this experimental model.	Vitamin D	110-119	KRAS proto-oncogene, GTPase	Rattus norvegicus	43-48
35099571-8	2022	It is known that the numbers of CD4+ and CD8+ T lymphocytes decrease in vitamin D deficiency while vitamin D supplementation increases CD + 4 lymphocytes.	Vitamin D	72-81	CD4 molecule	Sus scrofa	32-35
1655638-1	1991	C57Bl/6 female mice fed a Vitamin D (VIT-D)-deficient diet had serum levels of 25-hydroxyvitamin D decreasing with the time of diet exposure (3 and 8 weeks).	Vitamin D	26-35	vitrin	Mus musculus	37-40
35099571-8	2022	It is known that the numbers of CD4+ and CD8+ T lymphocytes decrease in vitamin D deficiency while vitamin D supplementation increases CD + 4 lymphocytes.	Vitamin D	72-81	CD8a molecule	Homo sapiens	41-44
2224592-1	1990	Vitamin D and its metabolites are tightly bound to the serum vitamin D-binding protein (DBP) and only the free hormone is considered to be physiologically active.	Vitamin D	0-9	D-box binding PAR bZIP transcription factor	Rattus norvegicus	88-91
35099571-8	2022	It is known that the numbers of CD4+ and CD8+ T lymphocytes decrease in vitamin D deficiency while vitamin D supplementation increases CD + 4 lymphocytes.	Vitamin D	99-108	CD8a molecule	Homo sapiens	41-44
35099571-12	2022	Thus, vitamin D supplementation could eliminate the suppressive effect of PD-L1 on CD4+ and CD8+ T cells, preventing lymphopenia and reducing disease severity and mortality in patients infected with COVID-19.	Vitamin D	6-15	CD8a molecule	Homo sapiens	92-95
35196255-2	2022	Key components of the vitamin D system, notably the vitamin D receptor (VDR) and the vitamin D activating enzyme (1alpha-hydroxylase), are present in a wide array of tissues, notably macrophages, dendritic cells and T lymphocytes (T cells) from the immune system.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	52-70
33815294-9	2021	In children with severe or refractory symptoms, FGF23 inhibition using burosumab may provide superior outcomes compared to conventional medical therapy with phosphate supplements and active vitamin D analogues.	Vitamin D	190-199	fibroblast growth factor 23	Homo sapiens	48-53
35196255-2	2022	Key components of the vitamin D system, notably the vitamin D receptor (VDR) and the vitamin D activating enzyme (1alpha-hydroxylase), are present in a wide array of tissues, notably macrophages, dendritic cells and T lymphocytes (T cells) from the immune system.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	72-75
35406694-1	2022	Vitamin D receptor (VDR) executes most of the biological functions of vitamin D.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	0-18
33803480-4	2021	Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	301-304
35406694-1	2022	Vitamin D receptor (VDR) executes most of the biological functions of vitamin D.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	20-23
33806559-3	2021	VDR gene polymorphism can influence individual predisposition to OP and response to vitamin D supplementation.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	0-3
35338345-8	2022	We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression.	Vitamin D	18-27	claudin 5	Mus musculus	111-120
33761087-4	2021	In this study, we evaluated the mRNA expression of VDR and PDIA3 involved in vitamin D signaling in cell lines representing different stages of PCa (PNT2, P4E6, LNCaP, DU145 and PC3).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	51-54
35338345-8	2022	We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression.	Vitamin D	18-27	claudin 5	Mus musculus	165-174
35405966-1	2022	The vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the transcription factor vitamin D receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	120-138
33232874-1	2021	Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs / alpha-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D.	Vitamin D	258-267	fibroblast growth factor 23	Homo sapiens	109-136
33232874-1	2021	Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs / alpha-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D.	Vitamin D	258-267	fibroblast growth factor 23	Homo sapiens	138-144
35405966-1	2022	The vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the transcription factor vitamin D receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	140-143
35405966-3	2022	Thus, the epigenome and transcriptome of VDR-expressing cells is directly affected by vitamin D.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	41-44
35318513-2	2022	Vitamin D in skin, through its receptors (VDR), regulates cell growth, differentiation, immune response and exerts both stimulatory and protective effects on melanocytes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	42-45
33813457-1	2021	OBJECTIVE: The aim: The objective of the study was to investigate the polymorphism of the vitamin D receptor (VDR) BsmI gene in children with growth hormone deficiency and the level of their vitamin D supply.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	110-113
35318513-3	2022	The gene sequence encoding VDR has polymorphic forms such as ApaI and TaqI that may affect vitamin D actions.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	27-30
35238975-2	2022	Furthermore, substantial progress has been made in the analysis of vitamin D metabolites and related biomarkers, such as vitamin D binding protein.	Vitamin D	67-76	GC vitamin D binding protein	Homo sapiens	121-146
33233840-1	2020	The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis.	Vitamin D	123-132	fibroblast growth factor 23	Homo sapiens	25-52
33233840-1	2020	The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis.	Vitamin D	123-132	fibroblast growth factor 23	Homo sapiens	54-59
24943330-5	2014	RESULTS: Neonatal mice that had in utero and early-life vitamin D deficiency had significantly increased pulmonary CD3(+) CD4(+) T1ST2(+) cells and reduced CD4(+) IL-10(+) cells.	Vitamin D	56-65	interleukin 1 receptor-like 1	Mus musculus	129-134
35218301-12	2022	CONCLUSION: Vitamin D maybe an alternative to acitretin in the treatment of congenital ichthyosis where it reduces the expression of RORgammat and IL-17.	Vitamin D	12-21	interleukin 17A	Homo sapiens	147-152
23662440-6	2012	Inhibitors of rennin-angiotensin system (rosiglitazone, angiotensin-converting enzyme inhibitors) and proper vitamin D supplementation may also up-regulate Klotho expression.	Vitamin D	109-118	klotho	Homo sapiens	156-162
23662440-9	2012	Proper supplementation with vitamin D increase the concentration of substrate for local 1,25(OH)2D synthesis 25(OH)D, which directly suppress PTH, increase Klotho, and decrease FGF-23 by proanabolic action on bone.	Vitamin D	28-37	klotho	Homo sapiens	156-162
23662440-9	2012	Proper supplementation with vitamin D increase the concentration of substrate for local 1,25(OH)2D synthesis 25(OH)D, which directly suppress PTH, increase Klotho, and decrease FGF-23 by proanabolic action on bone.	Vitamin D	28-37	fibroblast growth factor 23	Homo sapiens	177-183
35318258-8	2022	RESULTS: We show that serum level of vitamin D is negatively correlated with expression of programmed cell death-1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), but positively correlated with CD28 expression on CD8+ and Vgamma9Vdelta2+ T cells in patients with NSCLC.	Vitamin D	37-46	hepatitis A virus cellular receptor 2	Homo sapiens	236-241
12694466-3	2003	Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	19-37
12694466-3	2003	Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	39-42
35318258-8	2022	RESULTS: We show that serum level of vitamin D is negatively correlated with expression of programmed cell death-1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), but positively correlated with CD28 expression on CD8+ and Vgamma9Vdelta2+ T cells in patients with NSCLC.	Vitamin D	37-46	CD28	Sus scrofa	275-279
12694466-3	2003	Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	96-99
35318258-9	2022	1alpha,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	86-89
34352263-7	2022	Importantly, vitamin D and acitretin partly restored the PAD1 defect caused by IL-22.	Vitamin D	13-22	interleukin 22	Homo sapiens	79-84
35318258-9	2022	1alpha,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression.	Vitamin D	37-46	hepatitis A virus cellular receptor 2	Homo sapiens	136-140
35218642-7	2022	Higher levels of vitamin D can increase levels of anti-inflammatory mediators, CD4+ T lymphocytes and CD8+ T lymphocytes and CD3+ T lymphocytes in intratumoral tissue.	Vitamin D	17-26	CD8a molecule	Homo sapiens	102-105
34864062-9	2022	Moreover, it has been demonstrated that altered gene expression of VDR and 1,25D3-membrane-associated rapid response steroid-binding (1,25D3-MARRS) receptor influences the role of vitamin D within neurons and allows them to be more prone to degeneration.	Vitamin D	180-189	vitamin D receptor	Homo sapiens	67-81
35202418-9	2022	After vitamin D supplementation 25(OH)D, 1,25(OH)2D, PTH and VDBP levels were changed significantly compared to the placebo group.	Vitamin D	6-15	GC vitamin D binding protein	Homo sapiens	61-65
34779254-0	2022	Vitamin D supplementation induces CatG-mediated CD4+ T cell inactivation and restores pancreatic beta-cell function in mice with type 1 diabetes.	Vitamin D	0-9	CD4 antigen	Mus musculus	48-51
34979905-1	2022	BACKGROUND: Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).	Vitamin D	48-57	vitamin D receptor	Homo sapiens	132-158
34727512-2	2022	Vitamin D replete (VDR) status may prevent significant postparathyroidectomy hypocalcaemia; however, reports from previous studies are conflicting.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	19-22
34973430-0	2022	Immunomodulatory effect of vitamin D on the STATs and transcription factors of CD4+ T cell subsets in pregnant women with preeclampsia.	Vitamin D	27-36	signal transducer and activator of transcription 1	Homo sapiens	44-49
34973430-1	2022	This study evaluated the in vitro modulatory effect of vitamin D (VD) on T cells, by determining the expression of STATs and the transcription factors of each CD4+ T cell subsets.	Vitamin D	55-64	signal transducer and activator of transcription 1	Homo sapiens	115-120
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interleukin 17A	Homo sapiens	145-150
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interleukin 10	Homo sapiens	256-261
34735369-1	2021	BACKGROUND AND OBJECTIVES: CYP24A1 encodes a 24-hydroxylase involved in vitamin D catabolism, whose loss-of-function results in vitamin D-dependent hypercalcemia.	Vitamin D	72-81	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	27-34
34735369-1	2021	BACKGROUND AND OBJECTIVES: CYP24A1 encodes a 24-hydroxylase involved in vitamin D catabolism, whose loss-of-function results in vitamin D-dependent hypercalcemia.	Vitamin D	128-137	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	27-34
34836309-0	2021	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.	Vitamin D	20-29	intercellular adhesion molecule 1	Homo sapiens	177-182
34836309-9	2021	The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1.	Vitamin D	84-93	intercellular adhesion molecule 1	Homo sapiens	183-188
34749737-0	2021	The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection.	Vitamin D	14-23	interferon	None	59-69
34727991-11	2021	If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	63-66
34727991-11	2021	If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	105-108
34727991-11	2021	If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes.	Vitamin D	215-224	vitamin D receptor	Homo sapiens	105-108
34732414-2	2021	Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	35-53
34732414-2	2021	Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	55-58
34147708-3	2021	Elevated FGF23 results in renal phosphate wasting and compromised vitamin D activation, ultimately resulting in osteomalacia.	Vitamin D	66-75	fibroblast growth factor 23	Homo sapiens	9-14
34486787-4	2021	Here, it is aimed to investigate the effect of vitamin D-related polymorphisms (VDBP and VDR) and cholesterol-related variants of ApoE on Turkish MS patients.	Vitamin D	47-56	GC vitamin D binding protein	Homo sapiens	80-84
34486787-4	2021	Here, it is aimed to investigate the effect of vitamin D-related polymorphisms (VDBP and VDR) and cholesterol-related variants of ApoE on Turkish MS patients.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	89-92
34185245-0	2021	Vitamin D promotes autophagy in AML cells by inhibiting miR-17-5p-induced Beclin-1 overexpression.	Vitamin D	0-9	beclin 1	Homo sapiens	74-82
34185245-8	2021	Finally, through rescue assays, miR-17-5p facilitated the ability of cell proliferation, inhibited autophagy and apoptosis by modulating Beclin-1 in HL-60 cells following the treatment of 4 muM vitamin D.	Vitamin D	194-203	beclin 1	Homo sapiens	137-145
34185245-9	2021	Vitamin D promoted autophagy in AML cells by modulating miR-17-5p and Beclin-1.	Vitamin D	0-9	beclin 1	Homo sapiens	70-78
34324883-0	2021	Vitamin D deficiency attenuates endothelial function by reducing antioxidant activity and vascular eNOS expression in the rat microcirculation.	Vitamin D	0-9	nitric oxide synthase 3	Rattus norvegicus	99-103
34324883-10	2021	In conclusion, vitamin D deficiency impaired microvascular vasodilation, associated with eNOS downregulation and reduced antioxidant activity.	Vitamin D	15-24	nitric oxide synthase 3	Rattus norvegicus	89-93
34461573-3	2021	The aim of this study was to investigate the effects of vitamin D (25-hydroxy cholecalciferol (D3)) and estradiol on PAD2 gene expression level and its catalytic activity in rat C6 glioma cells.	Vitamin D	56-65	peptidyl arginine deiminase 2	Homo sapiens	117-121
34461573-7	2021	Conversely, vitamin D downregulated significantly the PAD2 gene expression level (P < 0.015) and its activity (P < 0.017).	Vitamin D	12-21	peptidyl arginine deiminase 2	Homo sapiens	54-58
34461573-8	2021	The study results suggested that estradiol conversely with vitamin D increases the activity of the PAD2 enzyme so that it might develop multiple sclerosis, especially in women.	Vitamin D	59-68	peptidyl arginine deiminase 2	Homo sapiens	99-103
34510707-0	2021	The complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine.	Vitamin D	34-43	ATP binding cassette subfamily G member 8	Homo sapiens	18-23
34450383-19	2021	CONCLUSION: To our knowledge, this study provided the first evidence that vitamin D suppressed GC cell growth both in vitro and in vivo through downregulating CD44.	Vitamin D	74-83	CD44 antigen	Mus musculus	159-163
34717752-17	2021	These data indicate the importance of megalin in BMMSCs for vitamin D"s role in skeletal health.	Vitamin D	60-69	LDL receptor related protein 2	Rattus norvegicus	38-45
34829802-2	2021	Vitamin D binding protein (DBP) is coded by the GC gene, is involved in the transport of vitamin D, and includes a number of isoforms based on single nucleotide polymorphisms (SNPs) in the coding region at rs7041 and rs4855.	Vitamin D	89-98	GC vitamin D binding protein	Homo sapiens	0-25
34835929-4	2021	RECENT FINDINGS: various cells (i.e., neurons, astrocytes, and microglia) within the central nervous system (CNS) express vitamin D receptors (VDR).	Vitamin D	122-131	vitamin D receptor	Homo sapiens	143-146
34661844-6	2022	After adjusting for potentially confounding factors, vitamin D had strong negative associations with serum concentrations of acrylamide hemoglobin adducts (HbAA, HbGA, and HbAA + HbGA).	Vitamin D	53-62	hemoglobin subunit gamma 1	Homo sapiens	162-166
34661844-6	2022	After adjusting for potentially confounding factors, vitamin D had strong negative associations with serum concentrations of acrylamide hemoglobin adducts (HbAA, HbGA, and HbAA + HbGA).	Vitamin D	53-62	hemoglobin subunit gamma 1	Homo sapiens	179-183
34661844-7	2022	The RCS plots demonstrated that vitamin D was inversely and nonlinearly associated with HbAA and HbAA + HbGA while inversely and linearly associated with HbGA, and also a striking difference when vitamin D was lower than 60 nmol/L.	Vitamin D	32-41	hemoglobin subunit gamma 1	Homo sapiens	104-108
34661844-7	2022	The RCS plots demonstrated that vitamin D was inversely and nonlinearly associated with HbAA and HbAA + HbGA while inversely and linearly associated with HbGA, and also a striking difference when vitamin D was lower than 60 nmol/L.	Vitamin D	32-41	hemoglobin subunit gamma 1	Homo sapiens	154-158
34661844-7	2022	The RCS plots demonstrated that vitamin D was inversely and nonlinearly associated with HbAA and HbAA + HbGA while inversely and linearly associated with HbGA, and also a striking difference when vitamin D was lower than 60 nmol/L.	Vitamin D	196-205	hemoglobin subunit gamma 1	Homo sapiens	104-108
34721296-0	2021	Overlapping Phenotypes Associated With CYP24A1, SLC34A1, and SLC34A3 Mutations: A Cohort Study of Patients With Hypersensitivity to Vitamin D.	Vitamin D	132-141	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	39-46
34721296-1	2021	Mutations in CYP24A1 (vitamin D 24-hydroxylase) and SLC34A1 (renal phosphate transporter NPT2a) cause autosomal recessive Infantile Hypercalcemia type 1 and 2, illustrating links between vitamin D and phosphate metabolism.	Vitamin D	187-196	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	13-20
34721296-1	2021	Mutations in CYP24A1 (vitamin D 24-hydroxylase) and SLC34A1 (renal phosphate transporter NPT2a) cause autosomal recessive Infantile Hypercalcemia type 1 and 2, illustrating links between vitamin D and phosphate metabolism.	Vitamin D	187-196	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	22-46
34979905-1	2022	BACKGROUND: Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).	Vitamin D	48-57	vitamin D receptor	Homo sapiens	160-163
35145798-17	2022	In this case report, we want to highlight the paramount importance of adequate tumor screening in adult patients with acquired hypophosphatemia, and the crucial lead that phosphate and vitamin D regulating hormones (FGF23) have for suspecting TIO.	Vitamin D	185-194	fibroblast growth factor 23	Homo sapiens	216-221
34304574-1	2021	BACKGROUND: the biological activity of vitamin D depends on the activity of its receptor or VDR.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	92-95
34304574-4	2021	Secondly, it was to verify if the status of some metabolic factors (oxidative stress, inflammation, lipid profile, and glycemia) in the serum, and gender-adjusted vitamin D levels are independent factors with an influence on the VDR methylation profile.	Vitamin D	163-172	vitamin D receptor	Homo sapiens	229-232
34304574-9	2021	CONCLUSION: we conclude that the methylation profile of the VDR gene is not influenced by the different BsmI polymorphism genotypes, and that serum vitamin D and serum markers of oxidative stress and inflammation can modulate this profile.	Vitamin D	148-157	vitamin D receptor	Homo sapiens	60-63
34950827-1	2021	Apart from its phosphaturic action, the bone-derived hormone fibroblast growth factor-23 (FGF23) is also an essential regulator of vitamin D metabolism.	Vitamin D	131-140	fibroblast growth factor 23	Homo sapiens	61-88
34950827-1	2021	Apart from its phosphaturic action, the bone-derived hormone fibroblast growth factor-23 (FGF23) is also an essential regulator of vitamin D metabolism.	Vitamin D	131-140	fibroblast growth factor 23	Homo sapiens	90-95
34950827-2	2021	The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules.	Vitamin D	104-113	fibroblast growth factor 23	Homo sapiens	25-30
34950827-2	2021	The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules.	Vitamin D	104-113	fibroblast growth factor 23	Homo sapiens	52-57
35092374-1	2022	BACKGROUND: The vitamin D receptor (VDR) is responsible for mediating the effects of vitamin D through regulation of other gene transcriptions.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	16-34
34950827-2	2021	The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules.	Vitamin D	229-238	fibroblast growth factor 23	Homo sapiens	25-30
34950827-2	2021	The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules.	Vitamin D	229-238	fibroblast growth factor 23	Homo sapiens	52-57
34950827-4	2021	The importance of FGF23 as regulator of vitamin D metabolism is underscored by the fact that in the absence of FGF23 signaling, the tight control of renal 1alpha-hydroxylase fails, resulting in overproduction of 1,25(OH)2D in mice and men.	Vitamin D	40-49	fibroblast growth factor 23	Mus musculus	18-23
34950827-5	2021	During recent years, big strides have been made toward a more complete understanding of the mechanisms underlying the FGF23-mediated regulation of vitamin D metabolism, especially at the genomic level.	Vitamin D	147-156	fibroblast growth factor 23	Homo sapiens	118-123
34950827-8	2021	The purpose of this review is to highlight our current understanding of the molecular mechanisms underlying the regulation of vitamin D metabolism by FGF23, and to discuss the role of these mechanisms in physiology and pathophysiology.	Vitamin D	126-135	fibroblast growth factor 23	Homo sapiens	150-155
34642495-0	2022	Correction: The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials.	Vitamin D	26-35	fibroblast growth factor 23	Homo sapiens	39-66
35092374-1	2022	BACKGROUND: The vitamin D receptor (VDR) is responsible for mediating the effects of vitamin D through regulation of other gene transcriptions.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	36-39
34274437-8	2021	The aggravation of cerebral ischemia caused by vitamin D deficiency is possibly due to up-regulating GRP78 and down-regulating CHOP in brain tissue.	Vitamin D	47-56	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	101-106
34995987-3	2022	RESULTS: 83% of the subjects had vitamin D deficiency further associated with VDR gene polymorphism (P 0.000).	Vitamin D	33-42	vitamin D receptor	Homo sapiens	78-81
35337634-1	2022	Cubilin (CUBN), the intrinsic factor-vitamin B12 receptor is a large endocytic protein involved in various physiological functions: vitamin B12 uptake in the gut; reabsorption of albumin and maturation of vitamin D in the kidney; nutrient delivery during embryonic development.	Vitamin D	205-214	cubilin	Homo sapiens	0-7
35337634-1	2022	Cubilin (CUBN), the intrinsic factor-vitamin B12 receptor is a large endocytic protein involved in various physiological functions: vitamin B12 uptake in the gut; reabsorption of albumin and maturation of vitamin D in the kidney; nutrient delivery during embryonic development.	Vitamin D	205-214	cubilin	Homo sapiens	9-13
35337634-1	2022	Cubilin (CUBN), the intrinsic factor-vitamin B12 receptor is a large endocytic protein involved in various physiological functions: vitamin B12 uptake in the gut; reabsorption of albumin and maturation of vitamin D in the kidney; nutrient delivery during embryonic development.	Vitamin D	205-214	cubilin	Homo sapiens	20-57
2553800-1	1989	We developed an immunohistochemical method for visualization of vitamin D (VDR) and estrogen receptors (ER) in cryostat sections, using monoclonal antibodies (MAb) to the vitamin D receptor and estrogen receptor, respectively.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	75-78
2804448-1	1989	The presence of the 28K vitamin D-dependent, calcium-binding protein (28K calbindin) was investigated by immunocytochemistry in normal thyroid glands and parathyroid glands of rats, guinea pigs, rabbits and men, as well as in human thyroid medullary carcinomas and human parathyroid adenomas.	Vitamin D	24-33	hippocalcin	Rattus norvegicus	45-68
2804448-1	1989	The presence of the 28K vitamin D-dependent, calcium-binding protein (28K calbindin) was investigated by immunocytochemistry in normal thyroid glands and parathyroid glands of rats, guinea pigs, rabbits and men, as well as in human thyroid medullary carcinomas and human parathyroid adenomas.	Vitamin D	24-33	hippocalcin	Rattus norvegicus	74-83
2656246-1	1989	The endogenous inhibitor of cAMP-dependent protein kinase (PKI) in chick kidney is regulated by the vitamin D status of the animal.	Vitamin D	100-109	tyrosine kinase 2	Gallus gallus	43-57
2656246-1	1989	The endogenous inhibitor of cAMP-dependent protein kinase (PKI) in chick kidney is regulated by the vitamin D status of the animal.	Vitamin D	100-109	tyrosine kinase 2	Gallus gallus	59-62
2542376-7	1989	These data provide evidence for the presence of a vitamin D microendocrine system in endothelial cells, consisting of the VDR and a 1 alpha-hydroxylase enzyme capable of producing 1,25(OH)2D3.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	122-125
2752207-3	1989	In X-linked hypophosphatemic mice (Hyp mice) maintained on a standard diet containing vitamin D, the basal level of intestinal calbindin-D28K was much lower (average 65.13 +/- 7.39%) than that in breeding pairs of normal mice maintained under the same conditions.	Vitamin D	86-95	calbindin 1	Mus musculus	127-131
2752207-4	1989	Although the mean intestinal level of calbindin-D28K was as low as 118.23 +/- 20.08 (SD) ng/mg protein in vitamin D-deficient mice (-D), the level of this protein was markedly increased to the control level (198.68 +/- 9.98 vs. 198.49 +/- 14.29 ng/mg protein of control) (P less than 0.001) in response to the administration of vitamin D3 (1000 I.U.	Vitamin D	106-115	calbindin 1	Mus musculus	38-42
2752207-6	1989	These results indicate that calbindin-D28K, biochemically indistinguishable from the chick intestinal calbindin-D28K, is present in the mouse intestine, and that the lower amount of this protein in the Hyp mouse intestine may, at least in part, be responsible for the resistance to the effects of vitamin D.	Vitamin D	297-306	calbindin 1	Mus musculus	28-32
2537329-12	1989	In summary, this vitamin D-dependent rickets, type II, kindred has a defect in the DNA-binding domain of VDR.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	105-108
3368450-3	1988	Immunoblotting and immunoprecipitation experiments with this antiserum indicate that BPP23 is a calcium-binding protein very similar, if not identical, to avian calbindin, the 28-kDa vitamin D-dependent calcium-binding protein.	Vitamin D	183-192	calbindin 1	Gallus gallus	161-170
3258165-0	1988	The plasma binding protein for vitamin D is a site of discrimination against vitamin D-2 compounds by the chick.	Vitamin D	31-40	dopamine receptor D2	Gallus gallus	85-88
2831435-7	1988	This was a much shorter half-life than that exhibited by other vitamin D metabolites and was expected because of the poor affinity 10-oxo-D3 has for the plasma vitamin D binding protein.	Vitamin D	63-72	GC vitamin D binding protein	Homo sapiens	160-185
3298546-1	1987	The Ca2+-binding proteins parvalbumin (Mr = 12K) and calbindin D28K [previously designated vitamin D-dependent Ca2+-binding protein (Mr = 28K)] are neuronal markers, but their functional roles in mammalian brain are unknown.	Vitamin D	91-100	parvalbumin	Homo sapiens	26-37
3040201-1	1987	The active vitamin D metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] causes marked suppression of both pre-proparathyroid hormone messenger RNA (pre-proPTH mRNA) and parathyroid hormone (PTH) secretion.	Vitamin D	11-20	parathyroid hormone	Bos taurus	112-131
3030988-1	1987	1 alpha,25-Dihydroxyvitamin D3, a hormonally active form of vitamin D, induces anchorage-independent growth of BALB/3T3 A31-1-1 and NIH/3T3 cells with concomitant increase of their mRNA level of c-Ki-ras but not of c-Ha-ras or c-myc, through a receptor-mediated mechanism.	Vitamin D	20-29	Harvey rat sarcoma virus oncogene	Mus musculus	215-223
3780539-1	1986	Administration of 650 pmol 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] to vitamin D-deficient chicks increased adenylate cyclase activity in the basolateral membrane of duodenal epithelial cells within 24 h. This increase in enzymatic activity was accompanied by an increase in calmodulin content of the basolateral membrane.	Vitamin D	41-50	calmodulin 2	Gallus gallus	274-284
2845731-10	1986	The incubation of GR cells with other vitamin D metabolites such as 25-hydroxyvitamin D3 (25(OH)D3) at a concentration of 10(-9) M does not significantly alter cell growth or morphology.	Vitamin D	38-47	interferon activated gene 205	Mus musculus	86-88
3463988-1	1986	Vitamin D-dependent 28-kDa calcium-binding protein (CaBP28) cDNA clones were isolated from a chicken intestinal library.	Vitamin D	0-9	calbindin 1	Gallus gallus	52-58
34578994-2	2021	This study aimed to assess a relationship between the VDR genotypes, plasma concentrations of vitamin D metabolites, and the occurrence of cardiovascular and metabolic disorders.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	54-57
34551392-7	2021	Learning points: Infantile hypercalcaemia type 1 (IIH) is an autosomal recessive disorder characterised by homozygous mutations in the CYP24A1 gene that encodes the 24-hydroxylase enzyme used to convert active vitamin D metabolites such as 1,25-(OH)2-vitamin D into their inactive form.	Vitamin D	210-219	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	135-142
34578960-0	2021	Investigating the Role of Functional Polymorphism of Maternal and Neonatal Vitamin D Binding Protein in the Context of 25-Hydroxyvitamin D Cutoffs as Determinants of Maternal-Neonatal Vitamin D Status Profiles in a Sunny Mediterranean Region.	Vitamin D	184-193	GC vitamin D binding protein	Homo sapiens	75-100
34578782-12	2021	The children in our study had a favorable VDR gene genotype, however the effect of VDR gene promoter activity might not be revealed due to very low vitamin D and calcium intake to stimulate intestinal calcium absorption which in turn affects HAZ.	Vitamin D	148-157	vitamin D receptor	Homo sapiens	83-86
34578802-2	2021	Vitamin D, mediated through the vitamin D receptor (VDR), has been identified as a protective nutrient against ionizing radiation (IR)-induced damage.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	32-50
34578802-2	2021	Vitamin D, mediated through the vitamin D receptor (VDR), has been identified as a protective nutrient against ionizing radiation (IR)-induced damage.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	52-55
34578802-4	2021	We first found that vitamin D induced VDR expression and inhibited IR-induced DNA damage and apoptosis in vitro.	Vitamin D	20-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	38-41
34484304-0	2021	Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.	Vitamin D	24-33	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	55-62
34484304-2	2021	Objective: This study aims to investigate whether 11 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (CYP2R1, CYP24A1, and CYP27B1) are associated with the risk of NAFLD.	Vitamin D	105-114	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	150-157
3755394-3	1986	This study was designed to determine whether calmodulin, the ubiquitous cell protein that binds and mediates many of the regulatory functions of Ca2+, plays a role in the regulation of renal vitamin D metabolism.	Vitamin D	191-200	calmodulin 2	Gallus gallus	45-55
3755394-4	1986	The calmodulin antagonists trifluoperazine (TFP), Janssen R24571, and the naphthalene sulfonamides W5 and W7 inhibited conversion of 25OHD3 to 1,25-(OH)2D3 by isolated renal tubules from vitamin D-deficient chicks in a dose-dependent manner (ED50: TFP, 12 mumol/liter; R24571, 10 mumol/liter; W7, 30 mumol/liter; W5, 75 mumol/liter).	Vitamin D	187-196	calmodulin 2	Gallus gallus	4-14
3768308-1	1986	It is well recognized that the vitamin D binding protein (DBP) is important for the transport of vitamin D, 25-hydroxyvitamin D (25-OH-D), and its metabolites.	Vitamin D	31-40	D-box binding PAR bZIP transcription factor	Rattus norvegicus	58-61
3732632-5	1986	The decreased concentrations of vitamin D metabolites in the adult Bantu diabetic patients may be partly explained by a concomitant decrease in the concentration of vitamin D-binding protein, possibly due to insulin deficiency.	Vitamin D	32-41	GC vitamin D binding protein	Homo sapiens	165-190
3713442-6	1986	Vitamin D sterols, such as 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, and 25,26-dihydroxyvitamin D3, are bound with high affinity by a plasma alpha-globulin - VDBP, also known as group-specific component (Gc).	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	165-169
3519280-5	1986	Parvalbumin was found to be independent of the vitamin D status of the animal since its concentration remained unchanged in kidney extracts of normal, rachitic and vitamin D-replete rats.	Vitamin D	164-173	parvalbumin	Rattus norvegicus	0-11
34221146-5	2021	The Panel notes that the upper level (UL) for one age group, i.e. children aged 4-10 years, is exceeded by 4%, when summing up the highest P95 estimate for the background diet (including food supplements) and the highest P95 estimate for vitamin D from the NF under the proposed uses and maximum use levels.	Vitamin D	238-247	neurofascin	Homo sapiens	257-259
2939728-4	1986	Active calcium transport varies directly and proportionately with the content of calcium-binding protein (CaBP), a specific molecular expression of the action of vitamin D.	Vitamin D	162-171	hippocalcin	Rattus norvegicus	81-104
34191826-3	2021	Given the long cold seasons with people wearing more clothes and reduced UV exposure, we aimed to study the association between the vitamin D metabolism-related gene CYP24A1 polymorphism and CRC susceptibility.	Vitamin D	132-141	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	166-173
2939728-4	1986	Active calcium transport varies directly and proportionately with the content of calcium-binding protein (CaBP), a specific molecular expression of the action of vitamin D.	Vitamin D	162-171	hippocalcin	Rattus norvegicus	106-110
34191826-10	2021	Individuals with CYP24A1 gene polymorphism may have an increased barrier for vitamin D absorption, thus contributing to the risk of CRC development.	Vitamin D	77-86	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	17-24
34206371-3	2021	The nuclear vitamin D receptor (VDR) is crucial for the phenotypic effects of vitamin D hydroxyderivatives.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	12-30
3949675-12	1986	The results demonstrated that the organoids maintained their differentiated function and tissuelike morphology for extended periods in vitro and therefore represent a suitable model system for studies on the long-term modulation of PTH secretion by vitamin D metabolites, ions, and other agents.	Vitamin D	249-258	parathyroid hormone	Bos taurus	232-235
34206371-3	2021	The nuclear vitamin D receptor (VDR) is crucial for the phenotypic effects of vitamin D hydroxyderivatives.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	32-35
34206371-8	2021	These results indicate that expression of VDR is important for the inhibition of melanoma growth induced by activated forms of vitamin D.	Vitamin D	127-136	vitamin D receptor	Homo sapiens	42-45
34203792-8	2021	Burosumab binds circulating intact FGF23 and blocks its biological effects in target tissues, resulting in increased serum inorganic phosphate (Pi) concentrations and increased conversion of inactive vitamin D to active 1,25-vitD.	Vitamin D	200-209	fibroblast growth factor 23	Homo sapiens	35-40
2999182-0	1986	Relationships among vitamin D, 25-hydroxyvitamin D, and vitamin D-binding protein concentrations in the plasma and milk of human subjects.	Vitamin D	20-29	GC vitamin D binding protein	Homo sapiens	56-81
34268038-20	2021	Interestingly, FGF-23 is shown to have a potential cardiovascular (CV) morbidity and mortality through various mechanisms like activation of myocardial FGF-23 receptors, endothelial dysfunction, inflammation, and altered phosphorus and vitamin D metabolisms.	Vitamin D	236-245	fibroblast growth factor 23	Homo sapiens	15-21
34150829-0	2021	Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury.	Vitamin D	24-33	glial fibrillary acidic protein	Rattus norvegicus	57-61
6321190-1	1984	Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR).	Vitamin D	97-106	vitamin D receptor	Homo sapiens	127-130
34072725-6	2021	Recent advances in demonstrating the important functions of vitamin D/vitamin D receptor (VDR) signaling in the regulation of stromal reprogramming, the microbiome, and immune response and the emergence of checkpoint immunotherapy provide opportunities for using vitamin D or its analogues as an adjunct for pancreatic cancer intervention.	Vitamin D	263-272	vitamin D receptor	Homo sapiens	90-93
6633158-0	1983	Evidence that sodium deprivation influences vitamin D dependent rat renal calcium binding protein.	Vitamin D	44-53	hippocalcin	Rattus norvegicus	74-97
34073299-6	2021	Apps were shown to be a valid tool to measure the dietary intake of vitamin D (r = 0.84) and calcium (r = 0.63).	Vitamin D	68-77	cathepsin B	Homo sapiens	0-4
34113565-4	2021	Vitamin D elucidates its biological responses by binding the vitamin D receptor; thus, promoting skeletal mineralization, and maintain calcium homeostasis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	61-79
34093899-0	2021	Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis.	Vitamin D	32-41	7-dehydrocholesterol reductase	Homo sapiens	63-68
34093899-2	2021	DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes.	Vitamin D	43-52	7-dehydrocholesterol reductase	Homo sapiens	0-5
34093587-1	2021	The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	126-144
34093587-1	2021	The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	146-149
34069442-5	2021	Activation of VDR with vitamin D (VitD), either calcitriol or its synthetic analog EB1089, sensitized MCF-7-derived, antiestrogen-resistant LCC9 human breast cancer cells to TAM, and attenuated increased UPR and pro-survival autophagy.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	14-17
34066482-3	2021	Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	123-141
34066482-6	2021	Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues.	Vitamin D	145-154	vitamin D receptor	Homo sapiens	15-33
34091780-3	2021	This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell and thus counters cancer in blood.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	39-42
34091780-3	2021	This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell and thus counters cancer in blood.	Vitamin D	13-22	retinoid X receptor alpha	Homo sapiens	43-46
34091780-10	2021	Also, the mRNA expression of VDR showed a positive and non-significant relationship with vitamin D levels and RXR expression (p > 0.05).	Vitamin D	89-98	vitamin D receptor	Homo sapiens	29-32
34251342-2	2021	It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	102-120
34251342-2	2021	It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	122-125
34540161-6	2021	Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group.	Vitamin D	24-33	thrombopoietin	Mus musculus	53-55
34540161-6	2021	Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group.	Vitamin D	24-33	thrombopoietin	Mus musculus	87-89
34408615-2	2021	Adjunctive vitamin D therapy may activate the Wnt/beta-catenin pathway that results in cell differentiation and proliferation via stem cell signalling.	Vitamin D	11-20	catenin (cadherin associated protein), beta 1	Mus musculus	50-62
34408615-7	2021	Results: beta-catenin and KRT20 showed a significant increase in the proliferation index of vitamin D at a dose of 0.6 mug/25.0 g (91.50 +- 4.09 and 48.75 +- 2.28, respectively; p < 0.05) compared to the colitis group.	Vitamin D	92-101	catenin (cadherin associated protein), beta 1	Mus musculus	9-21
34937516-1	2021	OBJECTIVE: To study the relationship between vitamin D deficiency, VDR gene polymorphism rs10735810 (A > G), and a missed abortion in the first trimester of gestation; to determine the predictors of its risk.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	67-70
35526529-11	2022	ChIP assays demonstrated the presence of a vitamin D response element (VDRE) in the nestin promoter, and paricalcitol enhanced the binding of VDR to VDRE.	Vitamin D	43-52	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	142-145
35334282-5	2022	Patients with vitamin D deficiency show worse renal function reflected by postoperative glomerular filtration rate (GFR) and more release of proinflammatory cytokine IL-1beta and IL-18.	Vitamin D	14-23	interleukin 18	Homo sapiens	179-184
35166042-4	2022	METHODS: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4).	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	65-72
35166042-4	2022	METHODS: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	78-81
35339045-2	2022	Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway expressed by activated T helper (Th) cells have been identified as MS risk genes by genome-wide association studies, CYP27B1 (25(OH)D3 1-alpha-hydroxylase) and CYP24A1 (1,25(OH)2D3 24-alpha-hydroxylase).	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	310-317
35339045-2	2022	Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway expressed by activated T helper (Th) cells have been identified as MS risk genes by genome-wide association studies, CYP27B1 (25(OH)D3 1-alpha-hydroxylase) and CYP24A1 (1,25(OH)2D3 24-alpha-hydroxylase).	Vitamin D	132-141	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	310-317
35401802-3	2022	However, only a limited number of studies have described the key role of vitamin D receptor (VDR) in the regulation of the functions of vitamin D and the potential effect of single nucleotide polymorphisms (SNPs) of the VDR gene.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	73-91
35401802-3	2022	However, only a limited number of studies have described the key role of vitamin D receptor (VDR) in the regulation of the functions of vitamin D and the potential effect of single nucleotide polymorphisms (SNPs) of the VDR gene.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	93-96
35401803-3	2022	Vitamin D and its subsequent pathway plays a key role in skin metabolism and homeostasis, with alterations in the level of vitamin D receptor (VDR) seen within pathological scars.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	123-141
35401803-3	2022	Vitamin D and its subsequent pathway plays a key role in skin metabolism and homeostasis, with alterations in the level of vitamin D receptor (VDR) seen within pathological scars.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	143-146
35254654-9	2022	Dual-luciferase assay confirmed that VDR could bind candidate vitamin D responsive elements (VDREs) in upstream region of Hsd3b1, and enhance gene expression.	Vitamin D	62-71	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	37-40
35202799-1	2022	Immune cells express the vitamin D receptor (VDR) and are therefore vitamin D targets.	Vitamin D	68-77	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	25-43
35202799-1	2022	Immune cells express the vitamin D receptor (VDR) and are therefore vitamin D targets.	Vitamin D	68-77	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	45-48
35339636-9	2022	Vitamin D inhibited mesenchymal transition in MCs and suppressed thrombospondin-1 expression via vitamin D receptor/Smad3 competition, contributing to the marked reduction in peritoneal dissemination in vivo.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	97-115
35349224-1	2022	BACKGROUND: Vitamin D-binding protein or group-specific component (Gc) is the major plasma carrier protein of Vitamin D.	Vitamin D	110-119	GC vitamin D binding protein	Homo sapiens	12-37
6633158-7	1983	The decrease in renal CaBP in rats fed the low sodium diet suggests for the first time that sodium is required for vitamin D dependent distal tubular calcium transport processes.	Vitamin D	115-124	hippocalcin	Rattus norvegicus	22-26
35470763-7	2022	Our results demonstrated that maternal vitamin D deficiency increased anxiety and depression-related behaviors, increased levels of TNF-alpha and IL-1beta in serum, and decreased prefrontal protein expressions of BDNF and VDR in adult male offspring.	Vitamin D	39-48	brain-derived neurotrophic factor	Rattus norvegicus	213-217
35470763-9	2022	CONCLUSION: It seems that developmental vitamin D deficiency disrupts brain development and has a long-lasting effect on VDR and BDNF signaling in the rat brain resulting in neuropsychiatric disorders in offspring.	Vitamin D	40-49	brain-derived neurotrophic factor	Rattus norvegicus	129-133
6617574-9	1983	These studies indicate that the vitamin D-dependent intestinal CaBP in hypophysectomized rats is regulated by GH and provide further evidence that the pituitary may be involved in regulating vitamin D-dependent intestinal adaptations.	Vitamin D	32-41	hippocalcin	Rattus norvegicus	63-67
35546959-9	2022	Vitamin D levels were lower in the symptomatic group (18.1 ng/mL +- 8.1 ng/mL) than the asymptomatic group (25.9 ng/mL +- 7.1 ng/mL) with a p-value of 0.000.	Vitamin D	0-9	thrombopoietin	Mus musculus	62-64
35546959-9	2022	Vitamin D levels were lower in the symptomatic group (18.1 ng/mL +- 8.1 ng/mL) than the asymptomatic group (25.9 ng/mL +- 7.1 ng/mL) with a p-value of 0.000.	Vitamin D	0-9	thrombopoietin	Mus musculus	75-77
6688582-1	1983	A calcium-binding protein (CaBP) similar to rat duodenal vitamin D-dependent CaBP was identified in rat uterus.	Vitamin D	57-66	hippocalcin	Rattus norvegicus	77-81
35546959-9	2022	Vitamin D levels were lower in the symptomatic group (18.1 ng/mL +- 8.1 ng/mL) than the asymptomatic group (25.9 ng/mL +- 7.1 ng/mL) with a p-value of 0.000.	Vitamin D	0-9	thrombopoietin	Mus musculus	116-118
35546959-9	2022	Vitamin D levels were lower in the symptomatic group (18.1 ng/mL +- 8.1 ng/mL) than the asymptomatic group (25.9 ng/mL +- 7.1 ng/mL) with a p-value of 0.000.	Vitamin D	0-9	thrombopoietin	Mus musculus	129-131
6947252-5	1981	These results suggest that the known amino acid sequence homology among calmodulin, troponin C, and S100b may be reflected in a similar functional domain present in these proteins but absent in parvalbumin and vitamin D-dependent protein.	Vitamin D	210-219	S100 calcium binding protein B	Bos taurus	100-105
35468986-1	2022	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	108-126
35468986-1	2022	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	128-131
6263587-11	1981	The CaBP synthesis in placenta and fetal membranes are vitamin D-dependent, and their regulation differs from that of intestinal CaBP.	Vitamin D	55-64	hippocalcin	Rattus norvegicus	4-8
35625724-2	2022	Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	12-15
204359-3	1978	The accumulation of cholecalciferol metabolites in the parotid gland was shown to be functional, as a calcium-binding protein was found to be present in the gland, possessing similar properties to the renal vitamin D-dependent calcium-binding protein.	Vitamin D	207-216	hippocalcin	Rattus norvegicus	227-250
35245207-2	2022	It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D3-vitamin D receptor (VDR)-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	94-115
35245207-2	2022	It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D3-vitamin D receptor (VDR)-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	117-120
35462022-9	2022	Vitamin D supplementation is recommended from the onset as a transcription factor to improve VDR and CAMP gene expression in leprosy patients.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	93-96
139939-0	1977	Renal calcium binding protein in the diabetic and vitamin D-depleted rat.	Vitamin D	50-59	hippocalcin	Rattus norvegicus	6-29
35517045-3	2022	Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	0-18
139939-4	1977	This contrasts markedly with responses of the duodenal protein to the same stimuli: (a) there was marked depression of duodenal calcium binding protein by vitamin D depletion and diabetes; (b) duodenal calcium binding protein was restored by vitamin D treatment of depleted rats.	Vitamin D	155-164	hippocalcin	Rattus norvegicus	128-151
35517045-3	2022	Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	20-23
35517045-9	2022	We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk VDR genotypes.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	193-196
139939-4	1977	This contrasts markedly with responses of the duodenal protein to the same stimuli: (a) there was marked depression of duodenal calcium binding protein by vitamin D depletion and diabetes; (b) duodenal calcium binding protein was restored by vitamin D treatment of depleted rats.	Vitamin D	242-251	hippocalcin	Rattus norvegicus	202-225
402385-1	1977	This study reports the development of a specific and sensitive radioimmunoassay and a simple and accurate radial immunodiffusion (RID) assay for the human serum-binding protein for vitamin D and its metabolites (DBP).	Vitamin D	181-190	growth hormone receptor	Homo sapiens	155-176
35456315-1	2022	Vitamin D analogs (VDAs) may directly inhibit the growth of normal and malignant (derived from acute lymphoblastic leukemia (ALL)) B cells, as both types of cells express vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	171-189
982945-4	1976	A further fall of the CaBP level, of the labelled calcium absorption and of the serumal Ca and P is observed with simultaneous action on the organism of the proteins and vitamin "D" deficiency.	Vitamin D	170-180	hippocalcin	Rattus norvegicus	22-26
35456315-1	2022	Vitamin D analogs (VDAs) may directly inhibit the growth of normal and malignant (derived from acute lymphoblastic leukemia (ALL)) B cells, as both types of cells express vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	191-194
35404942-0	2022	Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults.	Vitamin D	33-42	interleukin 17A	Homo sapiens	96-102
1208380-2	1975	The yield of previtamins and, consequently, vitamins D was higher with the use of erythemic lamps with luminophore E-2 and luminophore E-3 than with the use of lamps PRK-2.	Vitamin D	44-54	cystatin 12, pseudogene	Homo sapiens	115-118
1139439-9	1975	The results suggest that nutritional deficiencies from the rachitogenic diet, in addition to vitamin-D deficiency, inhibited CaBP synthesis.	Vitamin D	93-102	hippocalcin	Rattus norvegicus	125-129
35172759-9	2022	CONCLUSION: In hospitalized older adults with COVID-19, tomographic pulmonary involvement > 50%, anemia, vitamin D below 40 ng/mL, and CRP above 80 mg/L were independent risk factors for progression to SRF/MV.	Vitamin D	105-114	serum response factor	Homo sapiens	202-205
35252193-4	2022	In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related gamma-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation.	Vitamin D	27-36	gamma-glutamyl carboxylase	Rattus norvegicus	232-236
35252193-4	2022	In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related gamma-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation.	Vitamin D	27-36	matrix Gla protein	Rattus norvegicus	265-283
35252193-4	2022	In the rat epididymis, the vitamin D-related calcium-dependent TRPV6-TMEM16A channel-coupler has been shown to be involved in fluid transport, and, in a spatially complementary manner, vitamin K2-related gamma-glutamyl carboxylase (GGCX)-dependent carboxylation of matrix Gla protein (MGP) plays an essential role in promoting calcium-dependent protein aggregation.	Vitamin D	27-36	matrix Gla protein	Rattus norvegicus	285-288
35204769-6	2022	This study aimed to evaluate the vitamin D contribution in the expression of VDR and CYP27B1, involved in the conversion of an inactive to an active form of vitamin D in the infected macrophages using M. tuberculosis as an infection model.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	77-80
1139440-3	1975	Pigs made rachitic by a diet deficient in calcium and in vitamin D had concentrations of intestinal CaBP no less than values obtained on control pigs.	Vitamin D	57-66	S100 calcium binding protein G	Sus scrofa	100-104
35204769-6	2022	This study aimed to evaluate the vitamin D contribution in the expression of VDR and CYP27B1, involved in the conversion of an inactive to an active form of vitamin D in the infected macrophages using M. tuberculosis as an infection model.	Vitamin D	157-166	vitamin D receptor	Homo sapiens	77-80
35204769-7	2022	The expression of LL37 and the nucleus translocation of VDR were evaluated as the readout of the response of vitamin D and determined if those processes are affected by glucose concentrations.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	56-59
33895119-2	2021	However, for the implementation of a vitamin D based cancer therapy the increased deactivation of calcitriol in cancer cells by overexpressed CYP24A1 hydroxylase should be suppressed.	Vitamin D	37-46	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	142-149
35204769-9	2022	The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	64-67
35204769-9	2022	The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	113-116
31291127-2	2021	The activated form of vitamin D (1 alpha,25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	73-91
35282483-1	2022	CYP24A1 is an enzyme that inactivates vitamin D and encodes vitamin D 24-hydroxylase.	Vitamin D	38-47	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
35282483-1	2022	CYP24A1 is an enzyme that inactivates vitamin D and encodes vitamin D 24-hydroxylase.	Vitamin D	38-47	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-84
33853023-1	2021	The hypercalcemic effects of the hormone 1alpha,25-dihydroxyvitamin D3 (calcitriol) and most of known vitamin D metabolites and analogs call for the development of non secosteroidal vitamin D receptor (VDR) ligands as new selective and noncalcemic agonists for treatment of hyperproliferative diseases.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	182-200
35063211-2	2022	The relation of vitamin D and its blood carrier, vitamin D binding protein (VDBP), to mental health is still unknown.	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	49-74
35063211-2	2022	The relation of vitamin D and its blood carrier, vitamin D binding protein (VDBP), to mental health is still unknown.	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	76-80
35090436-1	2022	BACKGROUND: Tumor-induced osteomalacia (TIO) is a rare, acquired disease of renal phosphate wasting and disturbed vitamin D homeostasis as a result of the action of a phosphaturic protein - FGF-23, produced by a neoplasm.	Vitamin D	114-123	fibroblast growth factor 23	Homo sapiens	190-196
32627088-1	2021	BACKGROUND: Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	71-89
35084728-0	2022	The effect of vitamin D on GATA3 gene expression in peripheral blood mononuclear cells in allergic asthma.	Vitamin D	14-23	GATA binding protein 3	Homo sapiens	27-32
35084728-6	2022	In this study, given its immunomodulatory properties, we aimed to investigate the effects of different concentrations of vitamin D on GATA3 gene expression in peripheral blood mononuclear cells (PBMCs), including Th2 cells, and compare GATA3 expression levels between PBMCs taken from allergic asthmatic patients and healthy controls.	Vitamin D	121-130	GATA binding protein 3	Homo sapiens	134-139
35084728-9	2022	In addition, in the control group, cells co-cultured with vitamin D had a significantly increased GATA3 expression.	Vitamin D	58-67	GATA binding protein 3	Homo sapiens	98-103
35084728-11	2022	By contrast, incubation with vitamin D at the concentration of 10-6 M slightly decreased the expression of GATA3 among patients.	Vitamin D	29-38	GATA binding protein 3	Homo sapiens	107-112
35084728-12	2022	CONCLUSION: In summary, it is likely that vitamin D should regulate GATA3 gene expression in the PBMCs in a dose-dependent manner.	Vitamin D	42-51	GATA binding protein 3	Homo sapiens	68-73
32627088-1	2021	BACKGROUND: Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	91-94
34045549-15	2021	The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	76-79
34045549-15	2021	The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	165-168
34045549-15	2021	The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	76-79
34045549-15	2021	The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	165-168
34013750-3	2021	Skeletal muscle expresses the vitamin D receptor (VDR), which responds to the active form of vitamin D, 1,25-dihydroxyvitamin D3 by altering gene expression in target cells.	Vitamin D	30-39	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	50-53
34015387-0	2021	Vitamin D status in Hashimoto"s thyroiditis and its association with vitamin D receptor genetic variants.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	69-87
34015387-13	2021	Moreover, patients with FokI AA genotype have statistically higher levels of 25-OH-vitamin D3 suggesting VDR dysfunction even in patients expressing normal level of vitamin D.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	105-108
35208518-5	2022	In Hashimoto"s disease, vitamin D deficiency appears to be correlated with a higher titer of anti-TPO antibodies and with thyroid volume, and supplementation was associated with reduction of antibodies in some studies.	Vitamin D	24-33	thyroid peroxidase	Homo sapiens	98-101
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	81-99
34935629-2	2022	It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	53-71
34935629-2	2022	It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	73-76
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	101-104
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	tryptophan hydroxylase 2	Homo sapiens	144-168
34054418-5	2021	The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism.	Vitamin D	31-40	tryptophan hydroxylase 2	Homo sapiens	170-174
33420892-12	2021	CONCLUSIONS: The prevalence of vitamin D deficiency was higher in patients with eGFR 30 - < 60 mL/min/1.73 m2 than those with eGFR >= 60 mL/min/1.73 m2.	Vitamin D	31-40	thrombopoietin	Mus musculus	95-97
35386604-17	2022	Similarities in the biochemical profiles of HHRH and CYP24A1 deficiency suggest elevated active vitamin D and hypercalciuria may be potential cystogenic factors.	Vitamin D	96-105	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	53-60
35057792-12	2022	A new subset of macrophages with M2-type polarization double expressed MLPH + /CD206 + was found in mice having pneumoconiosis but markedly decreased after the Vitamin D treatment.	Vitamin D	160-169	mannose receptor, C type 1	Mus musculus	79-84
35057792-13	2022	Activated MLPH + /CD206 + M2 macrophages secreted TGF-beta1 and are sensitive to Vitamin D treatment.	Vitamin D	81-90	mannose receptor, C type 1	Mus musculus	18-23
33420892-12	2021	CONCLUSIONS: The prevalence of vitamin D deficiency was higher in patients with eGFR 30 - < 60 mL/min/1.73 m2 than those with eGFR >= 60 mL/min/1.73 m2.	Vitamin D	31-40	thrombopoietin	Mus musculus	137-139
34979083-2	2022	A significant regulator of vitamin-D metabolism is the inactivating function of the mitochondrial enzyme cytochrome P450 24A1 (CYP24A1).	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	105-125
34979083-2	2022	A significant regulator of vitamin-D metabolism is the inactivating function of the mitochondrial enzyme cytochrome P450 24A1 (CYP24A1).	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	127-134
34979083-10	2022	Taken together, this work presents an example of production of a challenging human CYP as well as providing details regarding hydrophobic modulation of a CYP-Adx complex that is critical to human vitamin-D metabolism.	Vitamin D	196-205	ferredoxin 1	Homo sapiens	158-161
33206298-2	2021	Previous studies analyzing 1alpha-hydroxylase or vitamin D receptor (Vdr) knockout mice revealed active vitamin D as a promising agent inhibiting LVH progression.	Vitamin D	49-58	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	69-72
35045292-3	2022	In this study, we report the occurrence of vitamin D-specific DNA demethylation and transcriptional activation at VDR binding sites associated with the acquisition of tolerogenesis in vitro.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	114-117
35055118-1	2022	The purpose of the study was to investigate the role of vitamin D binding protein (VDBP, DBP) and its polymorphism in the vitamin D pathway and human health.	Vitamin D	122-131	GC vitamin D binding protein	Homo sapiens	56-81
35055118-1	2022	The purpose of the study was to investigate the role of vitamin D binding protein (VDBP, DBP) and its polymorphism in the vitamin D pathway and human health.	Vitamin D	122-131	GC vitamin D binding protein	Homo sapiens	83-87
33172802-3	2021	The study aimed to analyze the relationship between ApaI and FokI polymorphisms of the VDR gene, serum vitamin D concentration, and BMD in patients with IBD.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	87-90
35055118-4	2022	Vitamin D binding protein bonds vitamin D and its metabolites and transports them to target tissues.	Vitamin D	32-41	GC vitamin D binding protein	Homo sapiens	0-25
35055118-8	2022	In this review, we aim to systematize the knowledge regarding the occurrence of diseases and their relationship with vitamin D deficiencies, which may be caused by polymorphisms in the VDBP gene.	Vitamin D	117-126	GC vitamin D binding protein	Homo sapiens	185-189
33866723-1	2021	OBJECTIVE: To evaluate the vitamin D receptor (VDR) gene polymorphisms and vitamin D levels in inactive hepatitis B virus (HBV) carriers.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	47-50
35057541-0	2022	Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	0-18
35057541-0	2022	Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	20-23
35057541-2	2022	VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	0-3
35057541-2	2022	VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	170-173
33792238-2	2021	Additionally, FGF23 interacts with vitamin D and parathyroid hormone in a complex metabolic pathway whose detailed mechanisms are still not clear in human physiology and disease.	Vitamin D	35-44	fibroblast growth factor 23	Homo sapiens	14-19
35053549-0	2022	Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	16-19
35057465-5	2022	Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements.	Vitamin D	179-188	vitamin D receptor	Homo sapiens	148-151
33784444-6	2021	Klotho protein participates in the regulation of several biological activities, including regulation of calcium-phosphate homeostasis and PTH as well as vitamin D metabolism.	Vitamin D	153-162	klotho	Mus musculus	0-6
35053218-10	2022	Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome.	Vitamin D	113-122	fibroblast growth factor 23	Homo sapiens	77-82
35053218-10	2022	Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome.	Vitamin D	113-122	klotho	Homo sapiens	162-168
35096006-9	2021	Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6.	Vitamin D	75-84	lipocalin 2	Homo sapiens	127-131
35096006-9	2021	Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6.	Vitamin D	75-84	major histocompatibility complex, class I, C	Homo sapiens	133-138
35096006-9	2021	Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6.	Vitamin D	75-84	allograft inflammatory factor 1 like	Homo sapiens	140-145
33753848-0	2021	A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	120-123
2505765-0	1989	Relations between vitamin D and fatty acid binding properties of vitamin D-binding protein.	Vitamin D	18-27	GC vitamin D binding protein	Bos taurus	65-90
33753848-8	2021	In conclusion, a directional network containing 47 partly novel primary VDR target transcription factors describes secondary responses in a highly complex vitamin D signaling cascade.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	72-75
33693593-0	2021	Vitamin D regulates CXCL12/CXCR4 and epithelial-to-mesenchymal transition in a model of breast cancer metastasis to lung.	Vitamin D	0-9	C-X-C motif chemokine receptor 4	Homo sapiens	27-32
2542952-0	1989	Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis.	Vitamin D	58-67	parvalbumin	Rattus norvegicus	0-11
33693593-3	2021	We investigate here the action mechanism for vitamin D in lung metastasis in the same non-immunodeficient model and demonstrate it involves the control of epithelial to mesenchymal transition as well as interactions between chemokine CXCL12 and its receptor CXCR4.	Vitamin D	45-54	chemokine (C-X-C motif) receptor 4	Mus musculus	258-263
33693593-5	2021	Vitamin D treatment also inhibits p-STAT3, Zeb1 and vimentin by 52%, 75% and 77% respectively, and increases E-cadherin by 87%.	Vitamin D	0-9	zinc finger E-box binding homeobox 1	Homo sapiens	43-47
33693593-6	2021	In vivo, dietary vitamin D deficiency maintains high levels of Zeb1 and p-STAT3 in cells from primary mammary tumors, and increases CXCL12 expression in lung stroma by 64%.	Vitamin D	17-26	zinc finger E-box binding homeobox 1	Homo sapiens	63-67
33693593-7	2021	In lung metastases, vitamin D deficiency increases CXCL12/CXCR4 co-localization by a factor of 2.5.	Vitamin D	20-29	C-X-C motif chemokine receptor 4	Homo sapiens	58-63
33249478-1	2021	CONTEXT: Human cytochrome P450 24 subfamily A member 1 (CYP24A1) loss-of-function mutations result in impaired activity of the 24-hydroxylase involved in vitamin D catabolism, thus inducing a vitamin D-dependent hypercalcemia.	Vitamin D	154-163	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	15-54
33249478-1	2021	CONTEXT: Human cytochrome P450 24 subfamily A member 1 (CYP24A1) loss-of-function mutations result in impaired activity of the 24-hydroxylase involved in vitamin D catabolism, thus inducing a vitamin D-dependent hypercalcemia.	Vitamin D	154-163	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	56-63
33249478-1	2021	CONTEXT: Human cytochrome P450 24 subfamily A member 1 (CYP24A1) loss-of-function mutations result in impaired activity of the 24-hydroxylase involved in vitamin D catabolism, thus inducing a vitamin D-dependent hypercalcemia.	Vitamin D	192-201	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	15-54
33249478-1	2021	CONTEXT: Human cytochrome P450 24 subfamily A member 1 (CYP24A1) loss-of-function mutations result in impaired activity of the 24-hydroxylase involved in vitamin D catabolism, thus inducing a vitamin D-dependent hypercalcemia.	Vitamin D	192-201	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	56-63
33690841-14	2021	Overexpression of intestinal epithelial VDR and vitamin D treatment resulted in a significantly increased Claudin-15.	Vitamin D	48-57	claudin 15	Mus musculus	106-116
33535006-15	2021	1,25-Vit D3 modulates fibroblast vitamin D enzymes through both the VDR and Pdia3 pathways in a species-dependent manner.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	68-71
33658032-8	2021	Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement.	Vitamin D	23-32	CD8a molecule	Homo sapiens	137-140
33658032-8	2021	Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement.	Vitamin D	23-32	CD8a molecule	Homo sapiens	172-175
33541709-6	2021	Hub genes, such as amyloid beta precursor protein (APP), CDH2, SPP1, and STC2, were significantly associated with functions related to extracellular matrix organization and vitamin D response.	Vitamin D	173-182	cadherin 2	Homo sapiens	57-61
33541709-6	2021	Hub genes, such as amyloid beta precursor protein (APP), CDH2, SPP1, and STC2, were significantly associated with functions related to extracellular matrix organization and vitamin D response.	Vitamin D	173-182	stanniocalcin 2	Homo sapiens	73-77
33418104-1	2021	The specific binding of active vitamin-D to the vitamin-D receptor (VDR) is closely related to the onset of immunological diseases.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	48-66
2851378-6	1988	The effect of vitamin D metabolites on cyclic AMP production was also observed in the presence of serum proteins and should be taken into account if unextracted plasma is assayed in the renal cortical membrane system for PTH bioactivity.	Vitamin D	14-23	parathyroid hormone	Canis lupus familiaris	221-224
2848683-4	1988	Renal membranes of vitamin D-deficient rats with secondary hyperparathyroidism had a reduced PLP-stimulated as well as PTH-stimulated adenylate cyclase response.	Vitamin D	19-28	parathyroid hormone-like hormone	Rattus norvegicus	93-96
33418104-1	2021	The specific binding of active vitamin-D to the vitamin-D receptor (VDR) is closely related to the onset of immunological diseases.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	68-71
33593830-4	2021	There is a plausible biological explanation since high-dose bolus replacement induces long-term expression of the catabolic enzyme 24-hydroxylase and fibroblast growth factor 23, both of which have vitamin D inactivating effects.	Vitamin D	198-207	fibroblast growth factor 23	Homo sapiens	150-177
3170556-1	1988	The potential calcium-binding protein p9Ka is related to S-100 protein and the vitamin D-dependent intestinal calcium-binding protein.	Vitamin D	79-88	S100 calcium-binding protein A4	Rattus norvegicus	38-42
3049577-2	1988	Studies of vitamin D-dependent 28-kilodalton calcium binding protein (calbindin D28) have been hindered by difficulties in purifying large amounts of the protein.	Vitamin D	11-20	hippocalcin	Rattus norvegicus	45-68
2889789-1	1987	The aetiology of the rise in plasma calbindin-D9K (vitamin D-induced calcium-binding protein; CaBP), following insulin-induced hypoglycaemia, was studied in the pig.	Vitamin D	51-60	S100 calcium binding protein G	Sus scrofa	36-49
3478696-0	1987	Calbindin-D in peripheral nerve cells is vitamin D and calcium dependent.	Vitamin D	41-50	calbindin 1	Gallus gallus	0-9
3478696-1	1987	The vitamin D-induced calcium-binding protein calbindin-D (CaBP) was localized immunohistochemically in some but not all of the cell bodies and axons within the intestinalis nerve of the chicken.	Vitamin D	4-13	calbindin 1	Gallus gallus	46-55
3595520-0	1987	Regulation by dietary calcium of vitamin D-dependent calcium-binding protein and active calcium transport in the small intestine of lactating rats.	Vitamin D	33-42	hippocalcin	Rattus norvegicus	53-76
3595520-1	1987	To test the hypothesis that vitamin D-dependent calcium-binding protein (CaBP) and active calcium (Ca) transport in the small intestine of vitamin D-replete lactating rats are regulated by dietary Ca intake, pregnant rats were given a high Ca (1.6% Ca and 1.4% phosphorus) or low Ca (0.1% Ca and 0.4% phosphorus) diet starting 3 days before delivery.	Vitamin D	28-37	hippocalcin	Rattus norvegicus	48-71
3595520-1	1987	To test the hypothesis that vitamin D-dependent calcium-binding protein (CaBP) and active calcium (Ca) transport in the small intestine of vitamin D-replete lactating rats are regulated by dietary Ca intake, pregnant rats were given a high Ca (1.6% Ca and 1.4% phosphorus) or low Ca (0.1% Ca and 0.4% phosphorus) diet starting 3 days before delivery.	Vitamin D	28-37	hippocalcin	Rattus norvegicus	73-77
3036623-3	1987	However, dexamethasone appeared to exert a significant, though modest, stimulatory influence upon calbindin-mRNA accumulation in the vitamin D-deficient (-D) intestine when measured 12 h after administration.	Vitamin D	133-142	calbindin 1	Gallus gallus	98-107
3036623-6	1987	Dexamethasone treatment of vitamin D-replete (+D) chicks resulted in a depression of calbindin-mRNA accumulation; levels were depressed to baseline with 250 nmol/bird.	Vitamin D	27-36	calbindin 1	Gallus gallus	85-94
33159963-1	2021	Fibroblast Growth Factor 23 (FGF23) is a bone-derived hormone that reduces kidney phosphate reabsorption and 1,25(OH)2 vitamin D synthesis via its required co-receptor alpha-Klotho.	Vitamin D	119-128	fibroblast growth factor 23	Mus musculus	0-27
33159963-1	2021	Fibroblast Growth Factor 23 (FGF23) is a bone-derived hormone that reduces kidney phosphate reabsorption and 1,25(OH)2 vitamin D synthesis via its required co-receptor alpha-Klotho.	Vitamin D	119-128	fibroblast growth factor 23	Mus musculus	29-34
33637199-3	2021	identify HBEGF as a paracrine/autocrine factor in the proximal tubules of mice that mimics the inductive effect of FGF23 on the vitamin D-catabolizing enzyme 24-hydroxylase through a common mitogen-activated protein kinase-dependent pathway.	Vitamin D	128-137	fibroblast growth factor 23	Mus musculus	115-120
33623633-13	2021	In conclusion, vitamin D deficiency causes eNOS downregulation and oxidative stress, thereby impairing the vascular function and posing an additional risk for microvascular complications in diabetes.	Vitamin D	15-24	nitric oxide synthase 3	Rattus norvegicus	43-47
33340772-6	2021	Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA.	Vitamin D	50-59	TNF superfamily member 11	Homo sapiens	102-107
3676238-4	1986	The 5-week vitamin D repletion (25 micrograms cholecalciferol/kg diet) regimen restored plasma Ca, P and alkaline phosphatase (EC 3.1.3.1) to normal, decreased PTH and markedly and rapidly increased plasma 25-hydroxycholecalciferol (25-OHD, sevenfold after 4 d) and 1,25-dihydroxycholecalciferol (1, 25(OH)2D3, 1.8-fold after 4 d).	Vitamin D	11-20	parathyroid hormone	Sus scrofa	160-163
33340772-6	2021	Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA.	Vitamin D	50-59	basic transcription factor 3 pseudogene 11	Homo sapiens	164-167
33340772-6	2021	Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA.	Vitamin D	50-59	TNF superfamily member 11	Homo sapiens	168-173
33340772-6	2021	Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA.	Vitamin D	50-59	C-X-C motif chemokine ligand 10	Homo sapiens	184-190
3755869-0	1986	Localization of vitamin D-dependent active Ca2+ transport in rat duodenum and relation to CaBP.	Vitamin D	16-25	hippocalcin	Rattus norvegicus	90-94
33036796-1	2021	OBJECTIVE: To study whether vitamin D (VitD) inhibits cell proliferation and Wnt/beta-catenin and transforming growth factor-beta (TGFbeta) signaling pathways in uterine leiomyomas independent of mediator complex subunit 12 (MED12) mutation status.	Vitamin D	28-37	Wnt family member 4	Homo sapiens	77-80
3755869-7	1986	It is concluded that vitamin D exerts its major regulation of active calcium transport in the rat duodenum via CaBP on transport steps beyond brush-border entry.	Vitamin D	21-30	hippocalcin	Rattus norvegicus	111-115
33259938-9	2021	These data suggested that vitamin D/VDR could alleviate cisplatin-induced acute renal injury partly by inhibiting NF-kappaB-mediated NLRP3/Caspase-1/GSDMD pyroptosis.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	36-39
33044390-2	2021	Mutations in the vitamin D receptor (VDR) gene can substantially affect serum vitamin D levels or alter its functionality, and can consequently increase susceptibility to developing MS.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
2427577-5	1986	To additionally define the oligosaccharide structure and identify precursors in biosynthetic pathways, DAF was studied in the HL-60 cell line differentiated by vitamin D toward monocytes.	Vitamin D	160-169	CD55 molecule (Cromer blood group)	Homo sapiens	103-106
3459646-0	1986	Distribution of vitamin D-dependent calcium-binding protein messenger ribonucleic acid in rat placenta and duodenum.	Vitamin D	16-25	hippocalcin	Rattus norvegicus	36-59
3459646-1	1986	The vitamin D-dependent calcium-binding protein (CaBP), cholecalcin or calbindin, is one of the best documented molecular expressions of 1,25-dihydroxyvitamin D, the hormonal metabolite of vitamin D.	Vitamin D	4-13	hippocalcin	Rattus norvegicus	24-47
3459646-1	1986	The vitamin D-dependent calcium-binding protein (CaBP), cholecalcin or calbindin, is one of the best documented molecular expressions of 1,25-dihydroxyvitamin D, the hormonal metabolite of vitamin D.	Vitamin D	4-13	hippocalcin	Rattus norvegicus	49-53
33188595-11	2021	CONCLUSIONS: The VMR was independent of VDBP concentration, whereas VDBP was strongly directly associated with the individual vitamin D metabolite concentrations.	Vitamin D	126-135	GC vitamin D binding protein	Homo sapiens	68-72
3503543-9	1986	The present data demonstrate that the cytochemical bioassay of PTH in a vitamin D-depleted animal is based on a dose-dependent difference in the time course of G6PD activity.	Vitamin D	72-81	parathyroid hormone	Bos taurus	63-66
3503543-9	1986	The present data demonstrate that the cytochemical bioassay of PTH in a vitamin D-depleted animal is based on a dose-dependent difference in the time course of G6PD activity.	Vitamin D	72-81	glucose-6-phosphate dehydrogenase	Bos taurus	160-164
33452895-1	2021	We investigated the effect of vitamin D supplementation on the expression of muscle vitamin D receptor (VDR) and cross-sectional area (CSA) in patients with a distal radius fracture (DRF).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	84-102
3753932-2	1986	The nuclei sampled were those in which receptors for 1,25-(OH)2D3 and/or vitamin D-dependent CaBP have been localized.	Vitamin D	73-82	hippocalcin	Rattus norvegicus	93-97
3753932-3	1986	Significant elevations in CAT activity were found in the arcuatemedian eminence and in the bed nucleus of the stria terminalis of rats made vitamin D replete by eight daily ip injections of 100 or 200 ng 1,25-(OH)2D3 as well as by constant intraventricular (ivi) infusion of 25 ng 1,25-(OH)2D3 for 7 days.	Vitamin D	140-149	choline O-acetyltransferase	Rattus norvegicus	26-29
33452895-1	2021	We investigated the effect of vitamin D supplementation on the expression of muscle vitamin D receptor (VDR) and cross-sectional area (CSA) in patients with a distal radius fracture (DRF).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	104-107
3958856-1	1986	Vitamin D binding protein (DBP) is the major carrier for vitamin D and its metabolites in serum.	Vitamin D	57-66	GC vitamin D binding protein	Homo sapiens	0-25
33452895-2	2021	Significant increases in VDR expression and CSA were observed, especially in vitamin D-deficient patients.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	25-28
33452895-4	2021	We evaluated the change in VDR expression and CSA in the forearm muscles following vitamin D supplementation in patients with a DRF.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	27-30
33452895-11	2021	Significant increases in VDR expression and CSA were observed in vitamin D-deficient patients [25(OH)D] < 20 ng/mL, but not in vitamin D-non-deficient patients.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	25-28
33452895-13	2021	CONCLUSION: Vitamin D supplementation may increase muscle VDR expression and CSA in patients with a DRF, especially in vitamin D-deficient patients.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	58-61
33452895-14	2021	The increase in CSA without an increase in VDR expression in some patients indicates that the effect of vitamin D supplementation on muscle mass could be mediated by indirect effect of serum vitamin D restoration and by VDR.	Vitamin D	104-113	vitamin D receptor	Homo sapiens	220-223
33453021-15	2021	The ALP MD was - 10.81 U/L (95% CI - 13.98, - 7.63), which indicated Vitamin D supplementation reduced its level.	Vitamin D	69-78	ATHS	Homo sapiens	4-7
33453021-17	2021	CONCLUSION: Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria.	Vitamin D	12-21	ATHS	Homo sapiens	115-118
33453021-17	2021	CONCLUSION: Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria.	Vitamin D	64-73	ATHS	Homo sapiens	115-118
33305808-3	2021	Here we describe that frataxin-deficient dorsal root ganglia neurons display low levels of ferredoxin 1, a mitochondrial Fe/S cluster-containing protein that interacts with frataxin and, interestingly, is essential for the synthesis of calcitriol, the active form of vitamin D.	Vitamin D	267-276	ferredoxin 1	Homo sapiens	91-103
33520985-2	2020	Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D.	Vitamin D	151-160	fibroblast growth factor 23	Mus musculus	31-36
33436077-2	2021	The active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, through the interaction with vitamin D receptor, exerts different activities on the innate and adaptive immune system, among which suppression of inflammation and promotion of tolerogenic responses.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	90-108
33469344-1	2021	Purpose: To investigate the association between vitamin D receptor (VDR) gene polymorphisms and vitamin D deficiency, overweightness/obesity, and metabolic syndrome (MetS) in a cohort of Han children residing in Hangzhou, China.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	68-71
33437393-5	2020	The second aim of this study is to investigate whether vitamin D levels are correlated with ECP or not.	Vitamin D	55-64	ribonuclease A family member 3	Homo sapiens	92-95
33376592-2	2020	Because vitamin D plays an important role in bone metabolism and immune system modulation, the aim of this study was to evaluate the influence of polymorphisms in vitamin D receptor genes (VDR) in the development of SpA.	Vitamin D	8-17	vitamin D receptor	Homo sapiens	163-181
33553988-1	2021	The hormonal vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)2D], produced in kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis.	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	137-155
33553988-1	2021	The hormonal vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)2D], produced in kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis.	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	157-160
33553988-2	2021	VDR is a ligand-controlled transcription factor that obligatorily heterodimerizes with retinoid X receptor (RXR) to target vitamin D responsive elements (VDREs) in the vicinity of vitamin D-regulated genes.	Vitamin D	123-132	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
33553988-2	2021	VDR is a ligand-controlled transcription factor that obligatorily heterodimerizes with retinoid X receptor (RXR) to target vitamin D responsive elements (VDREs) in the vicinity of vitamin D-regulated genes.	Vitamin D	180-189	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
32844222-0	2020	Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes.	Vitamin D	0-9	inducible T cell costimulator	Homo sapiens	36-40
32844222-0	2020	Vitamin D Supplementation modulates ICOS+ and ICOS- regulatory T cell in siblings of Children with Type 1 Diabetes.	Vitamin D	0-9	inducible T cell costimulator	Homo sapiens	46-50
32844222-11	2020	At baseline, in S subjects, a decreasing trend in Th17 and Treg/ICOS + values (p&0.05) from vitamin D deficiency to sufficiency was observed; 25(OH)D levels were negative predictors of Treg/ICOS + (R-square: 0.301) and Th17 percentages (R-square: 0.138).	Vitamin D	92-101	inducible T cell costimulator	Homo sapiens	64-68
33045433-0	2020	Insulin Sensitizing Effects of Vitamin D Repletion Mediated by Adipocyte Vitamin D Receptor: Studies in humans and mice.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	73-91
33045433-10	2020	Ad-VDR-KO mice mirrored the vitamin D deficient humans, displaying increased adipose tissue fibrosis and inflammation and hepatic insulin resistance.	Vitamin D	28-37	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	3-6
32430147-1	2020	BACKGROUND: Fibroblast growth factor 23 (FGF23), an important regulator of phosphate and vitamin D metabolism, has also been suggested to perform metabolic functions.	Vitamin D	89-98	fibroblast growth factor 23	Homo sapiens	12-39
32430147-1	2020	BACKGROUND: Fibroblast growth factor 23 (FGF23), an important regulator of phosphate and vitamin D metabolism, has also been suggested to perform metabolic functions.	Vitamin D	89-98	fibroblast growth factor 23	Homo sapiens	41-46
33330279-3	2020	Different variants in the loci of the genes responsible for the synthesis, hydroxylation, and transport of vitamin D (such as DHCR7, CYP2R1, CYP24A1, and GC), as well as VDR gene polymorphisms may also be associated with the risk of vitamin D deficiency.	Vitamin D	107-116	7-dehydrocholesterol reductase	Homo sapiens	126-131
33330279-14	2020	Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role.	Vitamin D	209-218	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	353-360
33330279-14	2020	Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role.	Vitamin D	209-218	vitamin D receptor	Homo sapiens	390-393
32391587-0	2020	Association of pre-diagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D-binding protein isoforms.	Vitamin D	30-39	GC vitamin D binding protein	Homo sapiens	124-149
3000745-5	1986	We have used a sensitive parameter for vitamin D action, the stimulation of creatine kinase BB (CKBB) activity, to measure the response of kidneys from vitamin D-deficient or normal rats.	Vitamin D	39-48	creatine kinase B	Rattus norvegicus	76-94
3000745-5	1986	We have used a sensitive parameter for vitamin D action, the stimulation of creatine kinase BB (CKBB) activity, to measure the response of kidneys from vitamin D-deficient or normal rats.	Vitamin D	39-48	creatine kinase B	Rattus norvegicus	96-100
3000745-5	1986	We have used a sensitive parameter for vitamin D action, the stimulation of creatine kinase BB (CKBB) activity, to measure the response of kidneys from vitamin D-deficient or normal rats.	Vitamin D	152-161	creatine kinase B	Rattus norvegicus	76-94
33202670-6	2020	Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	27-45
3000745-5	1986	We have used a sensitive parameter for vitamin D action, the stimulation of creatine kinase BB (CKBB) activity, to measure the response of kidneys from vitamin D-deficient or normal rats.	Vitamin D	152-161	creatine kinase B	Rattus norvegicus	96-100
3000745-9	1986	The stimulation of CKBB by vitamin D metabolites occurred in all the zones of the kidneys.	Vitamin D	27-36	creatine kinase B	Rattus norvegicus	19-23
3000745-11	1986	The increase of CKBB activity caused by the two vitamin D metabolites at different stages of development, closely correlated with changes in the presence of the 1,25(OH)2D3 receptor or the 24,25(OH)2D3 binding protein, suggests a specific role for each metabolite during renal development.	Vitamin D	48-57	creatine kinase B	Rattus norvegicus	16-20
33202670-6	2020	Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	47-50
4039542-6	1985	Utilizing vitamin D-deficient serum, serum depleted of the vitamin D-binding protein was not distinguishable from control serum in supporting the growth of human fibroblasts in vitro.	Vitamin D	10-19	GC vitamin D binding protein	Homo sapiens	59-84
33131491-2	2020	We hypothesized that vitamin D intake should refer to vitamin D receptor (VDR) expression.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	74-77
33131491-15	2020	It is expected that a more individualized vitamin D intake and a more accurate prognosis assessment can be recommended for BC patients based on the VDR expression.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	148-151
33275093-0	2020	Vitamin D increases the production of IL-10 by regulatory T cells in patients with systemic sclerosis.	Vitamin D	0-9	interleukin 10	Homo sapiens	38-43
32529210-11	2020	Vitamin D status was misclassified in 7 samples by the Roche assay and 3 by the IDS assay.	Vitamin D	0-9	iduronate 2-sulfatase	Homo sapiens	80-83
32737774-4	2020	In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting.	Vitamin D	46-55	TLR2	Sus scrofa	214-218
33126642-0	2020	Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways.	Vitamin D	16-25	chemokine (C-C motif) ligand 2	Mus musculus	134-168
33126642-0	2020	Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways.	Vitamin D	16-25	mitogen-activated protein kinase 8	Mus musculus	173-196
33126642-11	2020	Current data demonstrate that pirfenidone and vitamin D represent an attractive approach to ameliorate the cardiac fibrosis produced by doxorubicin through inhibiting both JNK1 signaling and MCP-1 inflammatory pathways, thus preserving heart function.	Vitamin D	46-55	mitogen-activated protein kinase 8	Mus musculus	172-176
33126642-11	2020	Current data demonstrate that pirfenidone and vitamin D represent an attractive approach to ameliorate the cardiac fibrosis produced by doxorubicin through inhibiting both JNK1 signaling and MCP-1 inflammatory pathways, thus preserving heart function.	Vitamin D	46-55	chemokine (C-C motif) ligand 2	Mus musculus	191-196
33091918-3	2021	Vitamin D has an immune-regulatory role and suppresses IL-17 production via direct transcriptional inhibition of IL-17 gene expression.	Vitamin D	0-9	interleukin 17A	Homo sapiens	55-60
33091918-3	2021	Vitamin D has an immune-regulatory role and suppresses IL-17 production via direct transcriptional inhibition of IL-17 gene expression.	Vitamin D	0-9	interleukin 17A	Homo sapiens	113-118
33091918-4	2021	OBJECTIVE: To explore the relationship of IL-17 and vitamin D levels with LP, and the possible inter-relationship between IL-17 and vitamin D.	Vitamin D	52-61	interleukin 17A	Homo sapiens	42-47
33091918-12	2021	However, a direct relationship between IL-17 and vitamin D deficiency could not be clarified.	Vitamin D	49-58	interleukin 17A	Homo sapiens	39-44
33132636-2	2020	Vitamin D receptor (VDR) is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH patients.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	0-18
33132636-2	2020	Vitamin D receptor (VDR) is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH patients.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	20-23
33132636-4	2020	It is known that VDR can interact with other ligands such as bile acids in addition to vitamin D, and its expression can be induced by fatty acids, and insulin.	Vitamin D	87-96	vitamin D receptor	Homo sapiens	17-20
33112809-2	2020	High FGF23 causes hypophosphataemia, reduced active vitamin D concentration and clinically manifests as rickets in children and osteomalacia in children and adults.	Vitamin D	52-61	fibroblast growth factor 23	Homo sapiens	5-10
33841529-0	2020	Association between Serum Vitamin D Concentration Status and Matrix Metalloproteinase-9 in Patients Undergoing Elective Percutaneous Coronary Intervention.	Vitamin D	26-35	matrix metallopeptidase 9	Homo sapiens	61-87
33841529-4	2020	According to the prevalence of vitamin D deficiency in our country, Iran, we aimed to evaluate the relationship between vitamin D status and the level of MMP-9 in patients undergoing percutaneous coronary intervention.	Vitamin D	120-129	matrix metallopeptidase 9	Homo sapiens	154-159
33841529-9	2020	The analysis showed that serum MMP-9 levels were higher in patients with lower vitamin-D concentrations.	Vitamin D	79-88	matrix metallopeptidase 9	Homo sapiens	31-36
33841529-10	2020	A significant inverse correlation was found between MMP-9 concentration and 25 (OH) vitamin D level (P = 0.039).	Vitamin D	84-93	matrix metallopeptidase 9	Homo sapiens	52-57
32721035-15	2020	In summary, we provide evidence that vitamin D is a novel endogenous regulator of TRPV1 channel activity that may play an important physiological role in addition to its known effects through the canonical nuclear vitamin D receptor pathway.	Vitamin D	37-46	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	214-232
33007912-0	2020	Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.	Vitamin D	0-9	glutamate receptor interacting protein 1	Mus musculus	32-36
33007912-0	2020	Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.	Vitamin D	0-9	glutamate receptor interacting protein 1	Mus musculus	47-51
32952100-9	2021	H-scores for VDR, Claudin-2 and E-cadherin were significantly lower in patients with vitamin D deficiency compared to patients with normal vitamin D level.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	13-16
32952100-10	2021	There were positive correlations between 25-OH vitamin D level and H-scores for VDR, E-cadherin and Claudin-2 in patient group.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	80-83
32952100-13	2021	Furthermore, deficiency of vitamin D was related to decreased expression of VDR and epithelial barrier proteins E-cadherin and Claudin-2.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	76-79
32986367-1	2020	BACKGROUND: Vitamin D inhibits cell proliferation via the vitamin D receptor (VDR), which may affect breast cancer risk.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	58-76
32986367-1	2020	BACKGROUND: Vitamin D inhibits cell proliferation via the vitamin D receptor (VDR), which may affect breast cancer risk.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	78-81
32654294-1	2020	The genomic actions of the vitamin D are mediated via its biologically most potent metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and the transcription factor vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	169-187
32654294-1	2020	The genomic actions of the vitamin D are mediated via its biologically most potent metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and the transcription factor vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	189-192
32654294-7	2020	Furthermore, also VDR seems to play a role in membrane-based responses to vitamin D.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	18-21
32592616-3	2020	The role of vitamin D is mediated by vitamin D receptors (VDR) in target cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	37-56
32592616-3	2020	The role of vitamin D is mediated by vitamin D receptors (VDR) in target cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	58-61
32775008-0	2020	Variants in SNAI1, AMDHD1 and CUBN in vitamin D pathway genes are associated with breast cancer risk: a large-scale analysis of 14 GWASs in the DRIVE study.	Vitamin D	38-47	cubilin	Homo sapiens	30-34
6490638-4	1984	Formation of the satellite cluster of CaBP in response to high doses of 1,25-dihydroxyvitamin D3 occurred in young rats which had been maintained on a vitamin D-deficient diet for 2 weeks, as well as in older rats which had been maintained on the same diet for 5 months.	Vitamin D	86-95	hippocalcin	Rattus norvegicus	38-42
31789949-3	2020	The aim of the current study is to evaluate the association between vitamin D status and vitamin D binding protein (VDBP) levels with serum cytokine and lipopolysaccharide binding protein (LBP) and to examine their role on disease severity and cirrhotics" mortality.	Vitamin D	68-77	GC vitamin D binding protein	Homo sapiens	89-114
6089793-1	1984	The amount of skin calcium-binding protein, evaluated using a sensitive radioimmunoassay and indirect immunofluorescence, was decreased in vitamin-D deficient rats and increased after one week vitamin D3 or 1 alpha-hydroxyvitamin D3 treatment.	Vitamin D	139-148	hippocalcin	Rattus norvegicus	19-42
6089793-2	1984	In vitamin D replete and in vitamin D-deficient animals, skin calcium-binding protein was not sensitive to changes in dietary and/or serum calcium concentrations.	Vitamin D	28-37	hippocalcin	Rattus norvegicus	62-85
31789949-3	2020	The aim of the current study is to evaluate the association between vitamin D status and vitamin D binding protein (VDBP) levels with serum cytokine and lipopolysaccharide binding protein (LBP) and to examine their role on disease severity and cirrhotics" mortality.	Vitamin D	68-77	GC vitamin D binding protein	Homo sapiens	116-120
31789949-3	2020	The aim of the current study is to evaluate the association between vitamin D status and vitamin D binding protein (VDBP) levels with serum cytokine and lipopolysaccharide binding protein (LBP) and to examine their role on disease severity and cirrhotics" mortality.	Vitamin D	68-77	lipopolysaccharide binding protein	Homo sapiens	153-187
6378596-1	1984	A sensitive double antibody RIA has been developed for the 28,000 mol wt rat renal vitamin D-dependent calcium-binding protein.	Vitamin D	83-92	hippocalcin	Rattus norvegicus	103-126
31789949-3	2020	The aim of the current study is to evaluate the association between vitamin D status and vitamin D binding protein (VDBP) levels with serum cytokine and lipopolysaccharide binding protein (LBP) and to examine their role on disease severity and cirrhotics" mortality.	Vitamin D	68-77	lipopolysaccharide binding protein	Homo sapiens	189-192
6378596-5	1984	The concentration of CaBP in the vitamin D-replete rat kidney is 7.3 +/- 1.0 (mean +/- SEM) micrograms/mg protein.	Vitamin D	33-42	hippocalcin	Rattus norvegicus	21-25
6378596-6	1984	In vitamin D-deficient rats the level of renal CaBP is 2.6 +/- 0.3 micrograms/mg protein.	Vitamin D	3-12	hippocalcin	Rattus norvegicus	47-51
32418499-1	2020	FGF-23 (fibroblast growth factor 23) regulates phosphorus and vitamin D.	Vitamin D	62-71	fibroblast growth factor 23	Homo sapiens	0-6
6423230-5	1984	In support of the first line of thought we report here the simultaneous occurrence of two different very high affinity Ca2+ binding proteins [vitamin-D-dependent CaBP = VD CaBP and parvalbumin = PV] in bones and teeth.	Vitamin D	142-151	parvalbumin	Homo sapiens	181-192
32418499-1	2020	FGF-23 (fibroblast growth factor 23) regulates phosphorus and vitamin D.	Vitamin D	62-71	fibroblast growth factor 23	Homo sapiens	8-35
32323557-9	2020	There was an increase in serum levels of IL-10 after 3 days from vitamin D treatment before surgery (vitamin D group = 4.4 +- 4.9 ng/mL and control group = 1 +- 0.5 ng/mL, P = .001).	Vitamin D	65-74	interleukin 10	Homo sapiens	41-46
32323557-9	2020	There was an increase in serum levels of IL-10 after 3 days from vitamin D treatment before surgery (vitamin D group = 4.4 +- 4.9 ng/mL and control group = 1 +- 0.5 ng/mL, P = .001).	Vitamin D	101-110	interleukin 10	Homo sapiens	41-46
32323557-10	2020	After operation, IL-10 increased in both groups, higher level in vitamin D group (P < .001).	Vitamin D	65-74	interleukin 10	Homo sapiens	17-22
6849391-9	1983	CaBP and the saturable transport process were highly correlated, further proof that both are vitamin D dependent.	Vitamin D	93-102	hippocalcin	Rattus norvegicus	0-4
32464532-11	2020	CONCLUSIONS: Our results suggest that GC-rs4588 is associated with lower serum 25(OH)D concentration in both Malaysian CWE and healthy children, while VDR-rs7975232A is associated with lower risk of vitamin D deficiency in Malaysian CWE of Malay ethnicity.	Vitamin D	199-208	vitamin D receptor	Homo sapiens	151-154
6299054-0	1982	Vitamin-D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats.	Vitamin D	0-9	gastrin	Rattus norvegicus	57-64
32884689-12	2020	Variants of GC (rs1155563) and CYP24A1 (rs6013897) were significantly associated with both 25(OH)D concentrations and vitamin D deficiency among pregnant women, respectively.	Vitamin D	118-127	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	31-38
6299054-0	1982	Vitamin-D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats.	Vitamin D	0-9	gastrin	Rattus norvegicus	66-73
6299054-0	1982	Vitamin-D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats.	Vitamin D	0-9	gastrin	Rattus norvegicus	66-73
6802844-0	1982	Alterations of the gamma-carboxyglutamic acid and osteocalcin concentrations in vitamin D-deficient chick bone.	Vitamin D	80-89	bone gamma-carboxyglutamate protein	Gallus gallus	50-61
6802844-5	1982	Surprisingly, the osteocalcin concentration is decreased 50% in vitamin D-deficient bone.	Vitamin D	64-73	bone gamma-carboxyglutamate protein	Gallus gallus	18-29
6802844-6	1982	From this we infer that accumulated Gla-containing protein in vitamin D-deficient and poorly mineralized bone may possibly represent a precursor of osteocalcin.	Vitamin D	62-71	bone gamma-carboxyglutamate protein	Gallus gallus	148-159
6894152-2	1981	The influence of the serum binding protein (DBP) for vitamin D and its metabolites on the concentration of its main ligands, 25-hydroxyvitamin D(3) (25-OHD(3)) and 1,25-dihydroxyvitamin D(3) (1,25-[OH](2)D(3)) was studied.	Vitamin D	53-62	growth hormone receptor	Homo sapiens	21-42
6893597-1	1980	The approximate association constants of the plasma vitamin D binding globulin (Gc-globulin) for 25-hydroxycholecalciferol (25(OH)D3) and the plasma 25(OH)D3 binding capacities were measured in samples from 123 patients with a variety of disorders.	Vitamin D	52-61	GC vitamin D binding protein	Homo sapiens	80-91
6774968-14	1980	The immunoprecipitation studies of DBP in rat serum showed that DBPs were common main transport proteins for naturally occurring vitamin D and its metabolites, and that DBP played some, but not a principal, role in the transport of synthetic 1 alpha-hydroxyvitamin D3.	Vitamin D	129-138	D-box binding PAR bZIP transcription factor	Rattus norvegicus	35-38
6774968-14	1980	The immunoprecipitation studies of DBP in rat serum showed that DBPs were common main transport proteins for naturally occurring vitamin D and its metabolites, and that DBP played some, but not a principal, role in the transport of synthetic 1 alpha-hydroxyvitamin D3.	Vitamin D	129-138	D-box binding PAR bZIP transcription factor	Rattus norvegicus	64-67
6246805-0	1980	Effects of vitamin D metabolites on bovine parathyroid hormone release in vitro.	Vitamin D	11-20	parathyroid hormone	Bos taurus	43-62
6767899-0	1980	Purification, characterization, and quantitation of the human serum binding protein for vitamin D and its metabolites.	Vitamin D	88-97	growth hormone receptor	Homo sapiens	62-83
494993-1	1979	A radioimmunoassay for porcine parathyroid hormone has been developed and applied to measure immunoreactive parathyroid hormone (PTH) in plasma of pigs with hereditary vitamin D dependency rickets (VDDR) (pseudovitamin D deficiency rickets).	Vitamin D	168-177	parathyroid hormone	Sus scrofa	129-132
469372-1	1979	This study evaluates the role of vitamin D metabolites in the genesis of the skeletal resistance to the calcemic action of PTH in uremia.	Vitamin D	33-42	parathyroid hormone	Canis lupus familiaris	123-126
438610-10	1979	Azotemic osteodystrophy characterized by a raised serum ALP and a prominent bone isoenzyme predicted a good response to vitamin D, and the decrease in serum ALP following vitamin D was the result of a reduction in the bone isoenzyme.	Vitamin D	171-180	ATHS	Homo sapiens	157-160
659599-1	1978	We studied the effects of vitamin D metabolites on parathyroid hormone (PTH) secretion.	Vitamin D	26-35	parathyroid hormone	Canis lupus familiaris	51-70
659599-1	1978	We studied the effects of vitamin D metabolites on parathyroid hormone (PTH) secretion.	Vitamin D	26-35	parathyroid hormone	Canis lupus familiaris	72-75
31446814-4	2021	The vitamin D receptor (VDR) is a crucial mediator of the pleiotropic cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
33713690-4	2021	Vitamin D and all its metabolites are circulating in blood bound to vitamin D binding protein, (VDBP).	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	68-93
33713690-4	2021	Vitamin D and all its metabolites are circulating in blood bound to vitamin D binding protein, (VDBP).	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	96-100
33705950-0	2021	Adequacy of calcium and vitamin D reduces inflammation, beta-catenin signaling, and dysbiotic Parasutterela bacteria in the colon of C57BL/6 mice fed a Western-style diet.	Vitamin D	24-33	catenin (cadherin associated protein), beta 1	Mus musculus	56-68
33647520-1	2021	Mature osteoclasts express the vitamin D receptor (VDR) and are able to respond to active vitamin D (1alpha, 25-dihydroxyvitamin D3; 1,25(OH)2D3) by regulating cell maturation and activity.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	51-54
33734544-4	2021	(VDD) and (VDI) were defined by vitamin D levels of <20 ng/ml and 21-30 ng/ml, respectively.	Vitamin D	32-41	VDI	Homo sapiens	11-14
33734544-5	2021	The mean vitamin D levels pre-HSCT, day +30, and +100 were suggestive of VDI, but normalized thereafter.	Vitamin D	9-18	VDI	Homo sapiens	73-76
34003583-1	2022	Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol, the active form of vitamin D.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	112-115
34055103-3	2021	It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases.	Vitamin D	41-50	fibroblast growth factor 23	Homo sapiens	92-97
33965570-8	2021	Given that the biological effects of D3 rely on its activation, and the binding of 1, 25(OH)2D3 to VDR in specific tissues, our findings provide novel insights into the possible role of vitamin D in the development and progression of influenza.	Vitamin D	186-195	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	99-102
31914352-8	2021	Deficient vitamin D state was associated with higher serum Th1 and Th2 cytokines compared to insufficient state, but the highest cytokine levels were observed in normal vitamin D state.	Vitamin D	10-19	negative elongation factor complex member C/D	Homo sapiens	59-62
31914352-9	2021	There was significant positive correlation between serum vitamin D and Th1 cytokines IL-2 and IL-8 as well as Th2 cytokines (ILs-3, 4, 5 and 9), but negative correlation with IL-13Conclusions: Serum Vitamin D and cytokines were lower in a sample of Nigerian children with asthma than controls.	Vitamin D	57-66	negative elongation factor complex member C/D	Homo sapiens	71-74
33760197-0	2021	MicroRNA-378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells.	Vitamin D	51-60	microRNA 378d	Mus musculus	0-13
33453076-2	2021	This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	98-116
33453076-2	2021	This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	118-121
33453076-2	2021	This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.	Vitamin D	46-55	GC vitamin D binding protein	Homo sapiens	158-183
33453076-8	2021	CONCLUSIONS: We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	165-168
33928687-0	2021	The effect of vitamin D supplementation on fibroblast growth factor-23 in patients with chronic kidney disease: A systematic review and meta-analysis.	Vitamin D	14-23	fibroblast growth factor 23	Homo sapiens	43-70
33928687-1	2021	This is a meta-analysis of randomized controlled trials (RCTs) investigating the effects of oral vitamin D supplementation on serum fibroblast growth factor-23 (FGF23) concentrations in patients with chronic kidney disease (CKD).	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	132-159
33928687-1	2021	This is a meta-analysis of randomized controlled trials (RCTs) investigating the effects of oral vitamin D supplementation on serum fibroblast growth factor-23 (FGF23) concentrations in patients with chronic kidney disease (CKD).	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	161-166
33928687-8	2021	However, further high-quality trials are required to identify the influence of oral vitamin D supplementation on FGF23 levels in patients with CKD.	Vitamin D	84-93	fibroblast growth factor 23	Homo sapiens	113-118
33879066-7	2021	In subgroup analysis, circulating VDBP was lower in MS patients (Ln-VDBP (mugr/ml): 3.64 +- 0.91 vs. 5.31 +- 0.77, p = 0.0001) even after adjusting for vitamin D levels, body mass index, and taking vitamin D supplement.	Vitamin D	152-161	GC vitamin D binding protein	Homo sapiens	34-38
33879066-7	2021	In subgroup analysis, circulating VDBP was lower in MS patients (Ln-VDBP (mugr/ml): 3.64 +- 0.91 vs. 5.31 +- 0.77, p = 0.0001) even after adjusting for vitamin D levels, body mass index, and taking vitamin D supplement.	Vitamin D	198-207	GC vitamin D binding protein	Homo sapiens	34-38
32884689-14	2020	Genetic mutants in the vitamin D pathway (GC and CYP24A1) were significantly associated with 25(OH)D levels in pregnant women in Eastern and Central China.	Vitamin D	23-32	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	49-56
32545801-2	2020	The active form of vitamin D (1,25(OH)2D3), which acts via its nuclear hormone receptor, vitamin D receptor (VDR), has been implicated in the treatment of Abeta pathology, and is thus considered as a neuroprotective agent.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	89-107
32545801-2	2020	The active form of vitamin D (1,25(OH)2D3), which acts via its nuclear hormone receptor, vitamin D receptor (VDR), has been implicated in the treatment of Abeta pathology, and is thus considered as a neuroprotective agent.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	109-112
32582667-6	2020	The bioactive form of vitamin D (aVD; 1, 25-Dihydroxyvitamin D3), which inhibits pro-inflammatory transcription factor NF-kappaB via the intracellular nuclear hormone receptor vitamin D receptor (VDR), was stably loaded into poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) filomicelles.	Vitamin D	22-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	176-194
32582667-6	2020	The bioactive form of vitamin D (aVD; 1, 25-Dihydroxyvitamin D3), which inhibits pro-inflammatory transcription factor NF-kappaB via the intracellular nuclear hormone receptor vitamin D receptor (VDR), was stably loaded into poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) filomicelles.	Vitamin D	22-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	196-199
31907922-4	2020	Treatment of cells with the active vitamin D metabolite 1,25(OH)2 D3 , results in transcriptional activation of the CYP24A1 gene, which encodes a 24-hydroxylase enzyme, that is, essential for physiological control of vitamin D3 levels.	Vitamin D	35-44	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	116-123
32020783-8	2020	RESULTS: In activity-limited mice, vitamin D deficiency accelerated the decrease in GA muscle weight, muscle fiber CSA, and grip strength and increased the protein expression of MuRF1, MAFbx, and FOXO3a (all P &lt; 0.05).	Vitamin D	35-44	tripartite motif-containing 63	Mus musculus	178-183
32213352-8	2020	Increased VDR and decreased CRAMP expression are consistent with previously reported associations between vitamin D deficiency, immune dysregulation, and suicidal behavior, and should lead to future studies uncovering novel interactive targets for suicide prevention.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	10-13
32228128-10	2020	Among those with the GA genotype, elevated CXCL10 levels were observed with higher than median ascorbic acid (beta = 0.004 +- 0.002, P = 0.047) or higher than median vitamin D status (beta = 0.003 +- 0.002, P = 0.044).	Vitamin D	166-175	C-X-C motif chemokine ligand 10	Homo sapiens	43-49
32228128-12	2020	CONCLUSION: The association between IL-1beta rs16944 genotype and CXCL10 levels was modified by the levels of ascorbic acid, alpha-tocopherol and vitamin D.	Vitamin D	146-155	C-X-C motif chemokine ligand 10	Homo sapiens	66-72
31959263-3	2020	In 699 healthy 8-11-year-old children, we genotyped SNPs in vitamin D-related genes (DHCR7 (rs12785878, rs3829251); GC (rs4588, rs7041, rs12512631); CYP2R1 (rs10741657, rs10500804, rs156292); CYP27B1 (rs10877012); CYP24A1 (rs2296241); VDR (rs757343, rs2228570, rs11568820)).	Vitamin D	60-69	7-dehydrocholesterol reductase	Homo sapiens	85-90
31959263-10	2020	However, VDR polymorphisms modified associations between vitamin D and some cardiometabolic markers in children.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	9-12
31959263-11	2020	This warrants further investigation of the role of VDR in the relationship between vitamin D-status and cardiometabolic risk.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	51-54
32471257-2	2020	Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	57-75
32471257-2	2020	Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	77-80
32471257-2	2020	Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	108-111
32414363-1	2020	AIMS: Vitamin D measurement is a composite of vitamin D2 (25(OH)D2) and D3 (25(OH)D3) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D2 supplements.	Vitamin D	6-15	immunoglobulin heavy diversity 2-15	Homo sapiens	54-56
32157737-3	2020	FGF23 is a hormone controlling renal phosphate and vitamin D metabolism.	Vitamin D	51-60	fibroblast growth factor 23	Mus musculus	0-5
31506976-7	2020	Under the chronic inflammation conditions of the DIO model, VDR activation by the vitamin D analog calcipotriol reduced liver inflammation and hepatic steatosis, significantly improving insulin sensitivity.	Vitamin D	82-91	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	60-63
31506976-11	2020	Conclusion: Activation of liver macrophage VDR by vitamin D ligands ameliorates liver inflammation, steatosis and insulin resistance.	Vitamin D	50-59	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	43-46
32229699-1	2020	The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH)2D3).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	45-48
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	3-12	vitamin D receptor	Homo sapiens	59-77
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	3-12	vitamin D receptor	Homo sapiens	79-82
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	3-12	vitamin D receptor	Homo sapiens	85-88
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	3-12	vitamin D receptor	Homo sapiens	85-88
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	79-82
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	85-88
33863283-2	2021	As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	85-88
33856702-1	2021	Genetic causes of vitamin D-related hypercalcemia are known to involve mutation of 25-hydroxyvitamin D-24-hydroxylase CYP24A1 or the sodium phosphate co-transporter SLC34A1; which result in excessive 1,25-(OH)2 D hormonal action.	Vitamin D	18-27	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	118-125
33935807-9	2021	Additionally, VDR knockdown results in decreased mitochondrial oxidative capacity and ATP production, suggesting that vitamin D is crucial for mitochondrial oxidative phosphorylation capacity; an important driver of muscle regeneration.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	14-17
33927639-8	2021	In cardiac tissue, vitamin D treatment induces an elevation significantly of the mRNA expression of Pgc1-alpha, Mfn-1, and Drp-1 genes (p = 0.001).	Vitamin D	19-28	collapsin response mediator protein 1	Mus musculus	123-128
33837680-1	2021	OBJECTIVES: X-linked hypophosphatemic rickets (XLH) is a congenital fibroblast growth factor (FGF)23-related metabolic bone disease that is treated with active vitamin D and phosphate as conventional therapies.	Vitamin D	160-169	fibroblast growth factor 23	Homo sapiens	94-100
33845559-18	2021	Vitamin D deficient patients needed a longer duration of hospitalization, more up gradation of antibiotics, PICU admissions, had more CPAP requirement, longer duration of PICU stay and longer duration of CPAP requirements as compared to vitamin D sufficient group.	Vitamin D	0-9	centromere protein J	Homo sapiens	134-138
33845559-18	2021	Vitamin D deficient patients needed a longer duration of hospitalization, more up gradation of antibiotics, PICU admissions, had more CPAP requirement, longer duration of PICU stay and longer duration of CPAP requirements as compared to vitamin D sufficient group.	Vitamin D	0-9	centromere protein J	Homo sapiens	204-208
33897704-5	2021	Its etiology is based on the one hand on polymorphisms within genes affecting the vitamin D system, causing susceptibility towards developing low vitamin D responsiveness and autoimmune diseases; on the other hand it is based on a blockade of vitamin D receptor signaling, e.g. through pathogen infections.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	243-261
33823058-0	2021	Exercise acutely increases vitamin D receptor (VDR) expression in T-lymphocytes in vitamin D deficient men, independent of age.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	47-50
33823058-4	2021	Moderate intensity cycling exercise increases vitamin D receptor expression in vitamin D deficient men, independent of age, presenting a strategy to combat the vitamin D epidemic.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	46-64
33823058-5	2021	ABSTRACT: Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR).	Vitamin D	10-19	vitamin D receptor	Homo sapiens	112-130
33823058-5	2021	ABSTRACT: Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR).	Vitamin D	10-19	vitamin D receptor	Homo sapiens	132-135
33917614-2	2021	Single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and vitamin D binding protein (GC gene) may interfere with vitamin D activity.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	62-65
32229699-3	2020	Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios.	Vitamin D	210-219	vitamin D receptor	Homo sapiens	94-97
32229699-3	2020	Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios.	Vitamin D	210-219	vitamin D receptor	Homo sapiens	163-166
32229699-6	2020	The number of persistent and transient VDR sites was found to be the main discriminator for sorting these TADs into five classes carrying vitamin D target genes involved in distinct biological processes.	Vitamin D	138-147	vitamin D receptor	Homo sapiens	39-42
32229699-7	2020	In conclusion, specific regulation of biological processes by vitamin D depends on differences in time-dependent VDR binding.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	113-116
32004705-2	2020	Vitamin D (1,25(OH)2D) is an important mediator of skeletal homeostasis that mediates its effect by binding to vitamin D receptor (VDR), a steroid family receptor and modulates various downstream pathways.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	111-129
32004705-2	2020	Vitamin D (1,25(OH)2D) is an important mediator of skeletal homeostasis that mediates its effect by binding to vitamin D receptor (VDR), a steroid family receptor and modulates various downstream pathways.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	131-134
32004706-0	2020	Fibroblast growth factor 23 counters vitamin D metabolism and action in human mesenchymal stem cells.	Vitamin D	37-46	fibroblast growth factor 23	Homo sapiens	0-27
32004706-3	2020	In this study, we tested the hypothesis that FGF23 inhibits vitamin D metabolism and action in hMSCs.	Vitamin D	60-69	fibroblast growth factor 23	Homo sapiens	45-50
32004706-8	2020	In vitro, rhFGF23 countered vitamin D-stimulated osteoblast differentiation of hMSCs by reducing the vitamin D receptor, CYP27B1/1alpha-hydroxylase, biosynthesis of 1alpha,25(OH)2D3, and signaling through BMP-7.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	101-119
32004706-8	2020	In vitro, rhFGF23 countered vitamin D-stimulated osteoblast differentiation of hMSCs by reducing the vitamin D receptor, CYP27B1/1alpha-hydroxylase, biosynthesis of 1alpha,25(OH)2D3, and signaling through BMP-7.	Vitamin D	28-37	bone morphogenetic protein 7	Homo sapiens	205-210
32004706-9	2020	These data demonstrate that dysregulated vitamin D metabolism in hMSCs may contribute to impaired osteoblastogenesis and altered bone and mineral metabolism in CKD subjects due to elevated FGF23.	Vitamin D	41-50	fibroblast growth factor 23	Homo sapiens	189-194
32032687-3	2020	Select stone formers may be at increased risk for recurrence with vitamin D supplementation, possibly from CYP24A1 gene mutations.	Vitamin D	66-75	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	107-114
32440968-0	2020	1,25(OH)D vitamin D promotes NOS2 expression in response to bacterial and viral PAMPs in primary bovine salivary gland fibroblasts.	Vitamin D	10-19	nitric oxide synthase 2	Bos taurus	29-33
32440968-9	2020	Their vitamin D-mediated enhancement of NOS2 expression warrants further investigation in saliva as a potential mechanism to boost oral immunity against infectious agents.	Vitamin D	6-15	nitric oxide synthase 2	Bos taurus	40-44
32353972-3	2020	The first hint of the significant role of vitamin D on the immune system was made by the discovery of the presence of the vitamin D receptor on almost all cells of the immune system.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	122-140
32349265-2	2020	At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	83-101
32349265-2	2020	At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	103-106
32045827-0	2020	Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor.	Vitamin D	7-16	fibroblast growth factor 23	Mus musculus	49-76
32045827-0	2020	Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor.	Vitamin D	7-16	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	120-138
32045827-0	2020	Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor.	Vitamin D	21-30	fibroblast growth factor 23	Mus musculus	49-76
32045827-0	2020	Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor.	Vitamin D	21-30	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	120-138
33029248-1	2020	Context: Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	68-86
33217447-1	2021	BACKGROUND: Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	77-95
33217447-1	2021	BACKGROUND: Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
33029248-1	2020	Context: Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	88-91
31889334-6	2020	Recent findings also suggest that part of the anti-cancer effects of vitamin D within squamous cell carcinoma - a type of skin cancer most directly linked to sun exposure - involves the DDIT4-mTOR catabolic signaling pathway to enhance cell autophagy.	Vitamin D	69-78	DNA damage inducible transcript 4	Homo sapiens	186-191
33000285-1	2021	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules.	Vitamin D	110-119	fibroblast growth factor 23	Homo sapiens	0-27
31210464-3	2020	Indeed, Vitamin D, through its receptor (VDR), decreases keratinocyte proliferation, improve their differentiation and modulate both cutaneous innate (antimicrobial activity and antigen presentation)and adaptative immunity (T and B lymphocyte function).	Vitamin D	8-17	vitamin D receptor	Homo sapiens	41-44
33000285-1	2021	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules.	Vitamin D	110-119	fibroblast growth factor 23	Homo sapiens	29-34
33002425-1	2021	BACKGROUND: Vitamin D is a steroid hormone that exerts its actions through ligation of the vitamin D receptor (VDR), a transcription factor of the nuclear receptor family.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	91-109
33002425-1	2021	BACKGROUND: Vitamin D is a steroid hormone that exerts its actions through ligation of the vitamin D receptor (VDR), a transcription factor of the nuclear receptor family.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	111-114
31770575-0	2020	Association between CUBN gene variants, type 2 diabetes and vitamin D concentrations in an elderly Greek population.	Vitamin D	60-69	cubilin	Homo sapiens	20-24
31770575-2	2020	The megalin-cubilin endocytotic system constitutes a key transport structure, with a modulating role in vitamin D metabolism.	Vitamin D	104-113	cubilin	Homo sapiens	12-19
31783153-0	2020	A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression.	Vitamin D	18-27	cathelicidin antimicrobial peptide	Mus musculus	42-76
31783153-2	2020	Mice and other mammals lack the vitamin D response element (VDRE) in their CAMP promoters.	Vitamin D	32-41	cathelicidin antimicrobial peptide	Mus musculus	75-79
32743796-2	2021	Vitamin D influences the expression of several genes in various pathways, including the CYP24A1 gene in the vitamin D metabolism pathway.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	88-95
31982424-0	2020	Active Form of Vitamin D Analogue Mitigates Neurodegenerative Changes in Alzheimer"s Disease in Rats by Targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways.	Vitamin D	15-24	Kelch-like ECH-associated protein 1	Rattus norvegicus	114-119
32743796-2	2021	Vitamin D influences the expression of several genes in various pathways, including the CYP24A1 gene in the vitamin D metabolism pathway.	Vitamin D	108-117	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	88-95
32743796-5	2021	Our results indicated that the transcription of CYP24A1, PFDN4, and nearby lncRNAs was affected by vitamin D treatment in HCT-116 and HT-29 cell lines.	Vitamin D	99-108	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	48-55
31982424-3	2020	The present study was conducted to evaluate the effects of active vitamin D analogue, Maxacalcitol, on Keap1-Nrf2 signaling pathway in experimental Alzheimer"s disease in rats.	Vitamin D	66-75	Kelch-like ECH-associated protein 1	Rattus norvegicus	103-108
32743796-5	2021	Our results indicated that the transcription of CYP24A1, PFDN4, and nearby lncRNAs was affected by vitamin D treatment in HCT-116 and HT-29 cell lines.	Vitamin D	99-108	prefoldin subunit 4	Homo sapiens	57-62
31629064-0	2020	Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression.	Vitamin D	27-36	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	107-114
31629064-12	2020	Here we will review our studies that have defined a finely balanced homeostatic control mechanism employed by PTH and FGF23 with catastrophic toxicity protection from 1,25(OH)2D3 in the genomic regulation of vitamin D metabolism and its accompanied control of mineral maintenance.	Vitamin D	208-217	fibroblast growth factor 23	Mus musculus	118-123
32082243-5	2020	Since IL-34 is critical to the homeostasis of microglia, and was previously shown to be induced in endothelial cells by vitamin D, we investigated IL-34 as the potential anti-inflammatory molecule induced in neurons by vitamin D.	Vitamin D	120-129	interleukin 34	Mus musculus	6-11
33035687-2	2021	Fibroblast growth factor 23 (FGF23), a hormone involved in phosphate, vitamin D and iron homeostasis, is linked to LVH and HF.	Vitamin D	70-79	fibroblast growth factor 23	Homo sapiens	0-27
33035687-2	2021	Fibroblast growth factor 23 (FGF23), a hormone involved in phosphate, vitamin D and iron homeostasis, is linked to LVH and HF.	Vitamin D	70-79	fibroblast growth factor 23	Homo sapiens	29-34
32648639-3	2021	Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	93-111
32648639-3	2021	Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	113-116
32715368-1	2021	INTRODUCTION: Vitamin D works by binding to vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	44-62
32715368-1	2021	INTRODUCTION: Vitamin D works by binding to vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	64-67
33624437-0	2021	Vitamin D Inhibits Adipokine Production and Inflammatory Signaling Through the Vitamin D Receptor in Human Adipocytes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	79-97
33624437-4	2021	Using RNA interference, we examined whether the vitamin D receptor (VDR) mediated vitamin D actions on adipokine expression and inflammatory signaling pathways in human adipocytes.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	68-71
33624437-11	2021	CONCLUSION: Vitamin D acts through VDR to inhibit inflammatory pathways and adipokine expression in human adipocytes.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	35-38
33692822-12	2021	Interpretation: Our results suggested that DHCR7 rs12785878 T>C might be associated with an increased risk of EOAD in the Chinese population, while other polymorphisms related to vitamin D insufficiency might not be.	Vitamin D	179-188	7-dehydrocholesterol reductase	Homo sapiens	43-48
33671779-11	2021	The intensity of eNOS immunostaining was decreased in Vitamin D deficient females.	Vitamin D	54-63	nitric oxide synthase 3	Rattus norvegicus	17-21
33241290-10	2021	This discrepancy may be due to further enhancement of circulating FGF23 and faster progression of CKD associated with reduced sKlotho and higher serum phosphate in vitamin D-treated patients.	Vitamin D	164-173	fibroblast growth factor 23	Homo sapiens	66-71
33728195-1	2021	Introduction In circulation, 99% vitamin D is transported by binding to vitamin D binding protein (VDBP) and albumin.	Vitamin D	33-42	GC vitamin D binding protein	Homo sapiens	72-97
33728195-1	2021	Introduction In circulation, 99% vitamin D is transported by binding to vitamin D binding protein (VDBP) and albumin.	Vitamin D	33-42	GC vitamin D binding protein	Homo sapiens	99-103
33488605-6	2020	The production of anti-osteoclastogenic cytokines, e.g., IL-4 and IL-10, is promoted by IL-33 and vitamin D, which are stimulators of both regulatory and Th2 cells.	Vitamin D	98-107	interleukin 10	Homo sapiens	66-71
33488605-9	2020	Emerging evidence suggests a functional link between vitamin D and the IL-33/ST2 axis, which acts through hormonal influences and immune-mediated effects, as well as cellular and metabolic functions.	Vitamin D	53-62	ST2	Homo sapiens	77-80
33435598-7	2021	Furthermore, statistically higher levels of interleukin-22 were observed in the group of children with vitamin D deficiency (p = 0.01), suggesting a proinflammatory alert state.	Vitamin D	103-112	interleukin 22	Homo sapiens	44-58
33405236-3	2021	Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D-VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	146-149
33405236-3	2021	Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D-VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases.	Vitamin D	193-202	vitamin D receptor	Homo sapiens	146-149
33397237-9	2021	Of note, the DHA has higher binding interactions to the mutated VDR (PDB id: 3VT7) when compared to the standard Vitamin-D.	Vitamin D	113-122	vitamin D receptor	Homo sapiens	64-67
32917645-6	2021	After 1 year of treatment, the mean COX-2/15-HPGD expression ratio in full-length crypts proportionately decreased 47% in the vitamin D group (P = 0.001), 46% in the calcium group (P = 0.002), and 34% in the calcium + vitamin D group (P = 0.03), relative to the placebo group.	Vitamin D	126-135	carbonyl reductase 1	Homo sapiens	42-49
32917645-7	2021	Among individuals with the functional vitamin D-binding protein isoform DBP2 (GC rs4588*A), the COX-2/15-HPDG ratio decreased 70% (P = 0.0006), 75% (P = 0.0002), and 60% (P = 0.006) in the vitamin D, calcium, and combined supplementation groups, respectively, relative to placebo.	Vitamin D	38-47	DEAH-box helicase 16	Homo sapiens	72-76
32917645-7	2021	Among individuals with the functional vitamin D-binding protein isoform DBP2 (GC rs4588*A), the COX-2/15-HPDG ratio decreased 70% (P = 0.0006), 75% (P = 0.0002), and 60% (P = 0.006) in the vitamin D, calcium, and combined supplementation groups, respectively, relative to placebo.	Vitamin D	189-198	DEAH-box helicase 16	Homo sapiens	72-76
32917645-8	2021	These results show that vitamin D and calcium favorably modulate the balance of expression of COX-2 and 15-HPGD-biomarkers of inflammation that are strongly linked to colorectal carcinogenesis-in the normal-appearing colorectal mucosa of colorectal adenoma patients (perhaps especially those with the DBP2 isoform).	Vitamin D	24-33	carbonyl reductase 1	Homo sapiens	104-111
32917645-8	2021	These results show that vitamin D and calcium favorably modulate the balance of expression of COX-2 and 15-HPGD-biomarkers of inflammation that are strongly linked to colorectal carcinogenesis-in the normal-appearing colorectal mucosa of colorectal adenoma patients (perhaps especially those with the DBP2 isoform).	Vitamin D	24-33	DEAH-box helicase 16	Homo sapiens	301-305
32503403-9	2021	CONCLUSION: Since vitamin D is capable of regulating the immune homeostasis and decreasing the autoimmune process through its receptor (VDR), it is regarded as a potential target for RA.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	136-139
33246082-0	2021	Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.	Vitamin D	39-48	retinoid X receptor alpha	Homo sapiens	19-22
32287103-3	2021	The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	53-71
32287103-3	2021	The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	73-76
32474936-6	2021	The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	91-109
32474936-6	2021	The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	111-114
32082243-5	2020	Since IL-34 is critical to the homeostasis of microglia, and was previously shown to be induced in endothelial cells by vitamin D, we investigated IL-34 as the potential anti-inflammatory molecule induced in neurons by vitamin D.	Vitamin D	219-228	interleukin 34	Mus musculus	147-152
32082243-7	2020	However, neutralizing IL-34 in vitamin D neuronal conditioned media only impacted IL-6 and not the broader anti-inflammatory phenotype of microglia.	Vitamin D	31-40	interleukin 34	Mus musculus	22-27
32013162-11	2020	In conclusion, vitamin D supplementation favourably enhanced GPx1 levels in adult Arabs with prediabetes, particularly in males.	Vitamin D	15-24	glutathione peroxidase 1	Homo sapiens	61-65
31942011-8	2020	In sum, our results show that vitamin D/VDR signaling induces miR-27a/b in oral lichen planus.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	40-43
32918226-2	2020	The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	107-125
32918226-2	2020	The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	127-130
32990627-1	2020	BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been reported in patients with ulcerative colitis, and polymorphism in the gene encoding the vitamin D binding protein can affect the characteristics of vitamin D binding protein, thus affecting the level and function of vitamin D in vivo.	Vitamin D	27-36	GC vitamin D binding protein	Homo sapiens	145-170
32990627-1	2020	BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been reported in patients with ulcerative colitis, and polymorphism in the gene encoding the vitamin D binding protein can affect the characteristics of vitamin D binding protein, thus affecting the level and function of vitamin D in vivo.	Vitamin D	145-154	GC vitamin D binding protein	Homo sapiens	205-230
31972611-4	2020	We investigated the expression of miR-346 and its 2 target genes, the receptor of vitamin D (VDR), and the tumor necrosis factor-alpha (TNF-alpha), which are known to modulate carcinogenesis.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	93-96
32370709-2	2020	During pregnancy, vitamin D homeostasis is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations.	Vitamin D	18-27	GC vitamin D binding protein	Homo sapiens	131-156
32370709-7	2020	An association between Vitamin D deficiency during pregnancy and a reduction in fetal brain development has been widely described and correlated with alteration in the expression of brain-derived neurotrophic factor.	Vitamin D	23-32	brain derived neurotrophic factor	Homo sapiens	182-215
31739978-5	2020	INTERVENTION(S): Mice were treated with vitamin D (0.5 mug/kg/d or 1 mug/kg/d) or vehicle for 21 or 60 days.	Vitamin D	40-49	opioid receptor, delta 1	Mus musculus	62-68
31102703-0	2020	Sex-specific role of CYP24A1 rs2762939 in the risk of essential hypertension based on the serum vitamin D and total renin concentrations.	Vitamin D	96-105	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	21-28
31593305-13	2020	Several studies show that 1,25-dihydroxyvitamin D3 and vitamin D analogs (synthetic vitamin D-like compounds) suppress proliferation and migration in human VDR-expressing glioma cell lines.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	156-159
31593305-13	2020	Several studies show that 1,25-dihydroxyvitamin D3 and vitamin D analogs (synthetic vitamin D-like compounds) suppress proliferation and migration in human VDR-expressing glioma cell lines.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	156-159
31704050-6	2020	Mean concentrations of serum bone measures in the vitamin D group were calcium (2.2 +- 0.1 mmol/L), phosphorus (1.7 +- 0.2 mmol/L), and ALK-P (178.7 +- 40.7 IU/L).	Vitamin D	50-59	ALK receptor tyrosine kinase	Homo sapiens	136-139
31866999-8	2019	In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	71-74
31748273-0	2019	Vitamin D binding protein is required to utilize skin-generated vitamin D.	Vitamin D	64-73	vitamin D binding protein	Mus musculus	0-25
31748273-5	2019	It has been assumed that cutaneous vitamin D is transported into the circulation by vitamin D binding protein (DBP), but experimental evidence is lacking.	Vitamin D	35-44	vitamin D binding protein	Mus musculus	84-109
31292859-3	2019	Recent evidence suggests vitamin D has a critical role in maintaining heart health through activation of the vitamin D receptor expressed in cardiomyocytes, and vitamin D deficiency may be implicated in the pathophysiology of HFrEF through activation of the renin-angiotensin system, impaired calcium handling, exaggerated inflammation, secondary hyperparathyroidism, pro-fibrotic properties, and proatherogenic potential.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	109-127
31398293-0	2019	Contribution of CYP27B1 and CYP24A1 Genetic Variations to the Incidence of Acute Coronary Syndrome and to Vitamin D Serum Level.	Vitamin D	106-115	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	28-35
32743932-8	2021	RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use.	Vitamin D	162-171	fibroblast growth factor 23	Homo sapiens	40-45
32743932-8	2021	RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use.	Vitamin D	229-238	fibroblast growth factor 23	Homo sapiens	40-45
33205696-10	2021	Moreover, in patients with vitamin D deficiency, the expression of TJ proteins (Occludin, claudin-1, ZO-1 and JAM-1) in the intestinal mucosa was reduced, and Treg cells in the peripheral blood were decreased, while Th17 cells were increased compared to those with vitamin D sufficiency and controls.	Vitamin D	27-36	claudin 1	Homo sapiens	90-99
33205696-10	2021	Moreover, in patients with vitamin D deficiency, the expression of TJ proteins (Occludin, claudin-1, ZO-1 and JAM-1) in the intestinal mucosa was reduced, and Treg cells in the peripheral blood were decreased, while Th17 cells were increased compared to those with vitamin D sufficiency and controls.	Vitamin D	27-36	F11 receptor	Homo sapiens	110-115
31690667-3	2019	As patients with melanoma commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signaling and replicated the findings in The Cancer Genome Atlas metastases.	Vitamin D	192-201	vitamin D receptor	Homo sapiens	202-205
31690667-8	2019	Vitamin D deficiency (<25 nmol/L ~ 10 ng/mL) shortened survival in primary melanoma in a VDR-dependent manner.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	89-92
31690667-9	2019	In vitro functional validation studies showed that elevated vitamin D-VDR signaling inhibited Wnt/beta-catenin signaling genes.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	70-73
32153675-0	2019	Effects of Vitamin D Supplements on IL-10 and INFgamma Levels in Patients with Multiple Sclerosis: a Systematic Review and Meta-Analysis.	Vitamin D	11-20	interleukin 10	Homo sapiens	36-41
33372187-2	2020	Vitamin D has been shown to stimulate the expression of the tryptophan hydroxylase 2 (TPH2) gene, which is the rate-limiting enzyme for serotonin production in the brain.	Vitamin D	0-9	tryptophan hydroxylase 2	Homo sapiens	60-84
33372187-2	2020	Vitamin D has been shown to stimulate the expression of the tryptophan hydroxylase 2 (TPH2) gene, which is the rate-limiting enzyme for serotonin production in the brain.	Vitamin D	0-9	tryptophan hydroxylase 2	Homo sapiens	86-90
32153675-2	2019	Objective: To conduct a systematic review and meta-analysis to estimate the effect of vitamin D supplements on IL-10 and INFgamma levels in patients with multiple sclerosis.	Vitamin D	86-95	interleukin 10	Homo sapiens	111-116
33424930-1	2020	Fibroblast growth factor 23 (FGF23), which is involved in the regulation of vitamin D, is an emerging independent risk factor for cardiovascular diseases.	Vitamin D	76-85	fibroblast growth factor 23	Homo sapiens	0-27
32153675-14	2019	More clinical trials are further needed to evaluate the effects of vitamin D supplements on IL-10 and INFgamma levels in patients with multiple sclerosis.	Vitamin D	67-76	interleukin 10	Homo sapiens	92-97
33424930-1	2020	Fibroblast growth factor 23 (FGF23), which is involved in the regulation of vitamin D, is an emerging independent risk factor for cardiovascular diseases.	Vitamin D	76-85	fibroblast growth factor 23	Homo sapiens	29-34
31702812-0	2019	BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D-deficient mice.	Vitamin D	91-100	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	72-75
31702812-7	2019	Furthermore, the expression levels of vitamin D receptor (VDR) and CYP27B1 protein in the BMDCs from the vitamin D-deficient mice were decreased compared with the control.	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-61
31747871-9	2019	Furthermore, RNAseq analyses revealed that the expression of genes for Maf family transcription factors, vitamin D receptors, and Dicps proteins is altered in tlr2 mutants with or without infection.	Vitamin D	105-114	toll-like receptor 2	Danio rerio	159-163
33004198-3	2020	RESULTS: Twelve studies in total, including 130,676 and 476 subjects, were analysed for the association between serum vitamin D levels and VDR polymorphisms with glaucoma, respectively.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	139-142
33004198-4	2020	Collectively, it was found that glaucoma patients have lower levels of vitamin D compared to controls (SMD=-1.16, 95% CI=-1.56--0.76, P<0.00001).	Vitamin D	71-80	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	103-109
33004198-7	2020	In addition, the vitamin D signalling cascade may be a contributing factor in developing glaucoma, which is supported by the evidence that b allele carriers of VDR BsmI exhibited an increase in the risk of glaucoma.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	160-163
31651513-16	2019	VD may regulate the formation and differentiation of adipocytes through the VDR and PPARgamma pathways and participate in the occurrence of GDM.	Vitamin D	0-2	vitamin D receptor	Homo sapiens	76-79
32771696-13	2020	The VDR is a viable target of muscle maintenance through testable Vitamin D molecules, as active molecules and analogs.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	4-7
31635074-4	2019	The results demonstrated an improvement of the insulin signalling pathway upon treatment with vitamin D alone, with significant increases in IR, PI3K, GLUT3, GLUT4 expression levels, as well as AKT phosphorylation and glucose uptake, while GSK3beta and TAU expression levels was decreased significantly.	Vitamin D	94-103	solute carrier family 2 member 3	Homo sapiens	151-156
33199033-0	2020	High-dose vitamin D administration and resistance exercise training attenuate the progression of obesity and improve skeletal muscle function in obese p62-deficient mice.	Vitamin D	10-19	nucleoporin 62	Mus musculus	151-154
32337495-2	2020	However, it is unknown whether this association depends on the functional GC-rs4588*A (Thr436Lys) variant encoding the vitamin D-binding protein-2 (DBP2) isoform, which may affect vitamin D status and bioavailability.	Vitamin D	119-128	DEAH-box helicase 16	Homo sapiens	148-152
33199033-10	2020	In conclusion, VitD administration attenuated the progression of obesity and preserved skeletal muscle function in p62-deficient mice.	Vitamin D	15-19	nucleoporin 62	Mus musculus	115-118
33331582-8	2020	Furthermore, the vitamin D deficient (<15 ng/ml) group showed a significantly higher plasma level of IL-6, IL-10, and IL-22 compared to the non-deficient (>=15 ng/ml) group.	Vitamin D	17-26	interleukin 10	Homo sapiens	107-112
33331582-8	2020	Furthermore, the vitamin D deficient (<15 ng/ml) group showed a significantly higher plasma level of IL-6, IL-10, and IL-22 compared to the non-deficient (>=15 ng/ml) group.	Vitamin D	17-26	interleukin 22	Homo sapiens	118-123
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	26-35	interleukin 22	Homo sapiens	220-225
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	interleukin 22	Homo sapiens	136-141
32117550-4	2019	Prescribing supplementary vitamin D as a part of the MS treatment plan can increase G6PD gene expression.	Vitamin D	26-35	glucose-6-phosphate dehydrogenase	Homo sapiens	84-88
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	interleukin 22	Homo sapiens	220-225
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	interleukin 22	Homo sapiens	136-141
33331582-10	2020	CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.	Vitamin D	154-163	interleukin 22	Homo sapiens	220-225
32117550-5	2019	The aim of this study was to determine the serum level of G6PD in patients with MS and NMO and its relationship with vitamin D, since it is yet to be explored thoroughly.	Vitamin D	117-126	glucose-6-phosphate dehydrogenase	Homo sapiens	58-62
33255834-2	2020	Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	39-57
32117550-11	2019	G6PD serum level was significantly higher in patients with MS who had previously consumed supplementary vitamin D compared to those who had not.	Vitamin D	104-113	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
33255834-2	2020	Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	59-62
32117550-13	2019	Also, supplementary vitamin D may induce favorable results on the G6PD level.	Vitamin D	20-29	glucose-6-phosphate dehydrogenase	Homo sapiens	66-70
33216035-3	2021	Vitamin D deficit and polymorphisms of the vitamin D receptor (VDR) gene are associated with high prevalence of mild cognitive impairment (MCI) and AD.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-61
31636627-1	2019	Vitamin D, together with its nuclear receptor (VDR), plays an important role in modulating the immune response, decreasing the inflammatory process.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	47-50
33216035-3	2021	Vitamin D deficit and polymorphisms of the vitamin D receptor (VDR) gene are associated with high prevalence of mild cognitive impairment (MCI) and AD.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	63-66
33216035-11	2021	CONCLUSION: We propose that the response to vitamin D treatment will depend on VDR polymorphisms, being more efficient in carriers of protective alleles of Apa I polymorphism.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	79-82
33186385-2	2020	Vitamin D action takes place through vitamin D receptor (VDR) activation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	37-55
33186385-2	2020	Vitamin D action takes place through vitamin D receptor (VDR) activation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	57-60
33186385-11	2020	CONCLUSIONS: Despite being preliminary, these findings suggest that genotyping of pregnant women for VDR polymorphisms may be useful for a tailored vitamin D supplementation strategy.	Vitamin D	148-157	vitamin D receptor	Homo sapiens	101-104
31582399-9	2019	CONCLUSION: Vitamin D enhances IFN-beta induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-beta alone.	Vitamin D	12-21	negative elongation factor complex member C/D	Homo sapiens	93-96
31274211-9	2019	Vitamin D seems to inhibit Th1 immune responses and have no effect on Th2 responses.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	27-30
33037402-5	2020	Differential methylation of Vitamin D Receptor binding sites and MS risk genes was assessed from this and using pyrosequencing for the vitamin D regulated MS risk gene ZMIZ1.	Vitamin D	135-144	vitamin D receptor	Homo sapiens	28-46
33289915-5	2020	Loss-of-function mutations in the genes CYP24A1 and SLC34A1, involved in vitamin D metabolism leading to hypercalcemia could not be found in this patient.	Vitamin D	73-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	40-47
33000217-0	2020	Vitamin D receptor knockdown attenuates the antiproliferative, pro-apoptotic and anti-invasive effect of vitamin D by activating the Wnt/beta-catenin signaling pathway in papillary thyroid cancer.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	0-18
31377240-0	2019	Vitamin D sterols increase FGF23 expression by stimulating osteoblast and osteocyte maturation in CKD bone.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	27-32
33000217-3	2020	Therefore, the present study aimed to determine the role of the VDR and its association with Wnt/beta-catenin signaling in vitamin D-treated PTC cells.	Vitamin D	123-132	vitamin D receptor	Homo sapiens	64-67
33000217-11	2020	In conclusion, the present study revealed that VDR-KD attenuated the antiproliferative, pro-apoptotic and anti-invasive effects of vitamin D in PTC by activating the Wnt/beta-catenin signaling pathway.	Vitamin D	131-140	vitamin D receptor	Homo sapiens	47-50
32940108-3	2020	Vitamin D binding protein (VDBP) has important functions, including transporting vitamin D and its metabolites to target cells.	Vitamin D	81-90	GC vitamin D binding protein	Homo sapiens	0-25
31415247-2	2019	In patients with thrombotic state and vitamin D deficiency, vitamin D analogs and vitamin D receptor activators have been determined as adjunctive anticoagulant treatment in previous studies.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	82-100
32940108-3	2020	Vitamin D binding protein (VDBP) has important functions, including transporting vitamin D and its metabolites to target cells.	Vitamin D	81-90	GC vitamin D binding protein	Homo sapiens	27-31
31250032-5	2019	Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects.	Vitamin D	38-47	advanced glycosylation end-product specific receptor	Homo sapiens	62-66
33084400-2	2020	Vitamin D receptor (VDR) is abundantly expressed in the distal region of small intestine, where the Paneth cells are enriched, suggesting that vitamin D signaling may modulates the intestinal Paneth cells and their production of defensins to restrain microbiome growth in the small intestine.	Vitamin D	143-152	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
33084400-2	2020	Vitamin D receptor (VDR) is abundantly expressed in the distal region of small intestine, where the Paneth cells are enriched, suggesting that vitamin D signaling may modulates the intestinal Paneth cells and their production of defensins to restrain microbiome growth in the small intestine.	Vitamin D	143-152	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
31250032-6	2019	This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D.	Vitamin D	164-173	advanced glycosylation end-product specific receptor	Homo sapiens	137-141
33060436-10	2021	However, IL-10 significantly increased after vitamin D supplementation.	Vitamin D	45-54	interleukin 10	Homo sapiens	9-14
31326626-0	2019	Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism.	Vitamin D	51-60	KRAS proto-oncogene, GTPase	Homo sapiens	92-96
31326626-0	2019	Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	122-125
33162978-4	2020	In an open pilot trial we aimed to improve efficacy of GAD-alum treatment using lymph-node administration in combination with oral vitamin D.	Vitamin D	131-140	glutamate decarboxylase 1	Homo sapiens	55-58
31326626-5	2019	The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs).	Vitamin D	171-180	KRAS proto-oncogene, GTPase	Homo sapiens	67-71
31326626-5	2019	The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs).	Vitamin D	171-180	vitamin D receptor	Homo sapiens	97-100
31187385-9	2019	Expression of LINC00346 was inversely correlated with vitamin D levels only in male epileptic patients (r = -0.58, P = 0.011).	Vitamin D	54-63	p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript	Homo sapiens	14-23
33133014-2	2020	The biologically active form of vitamin D, calcitriol, exerts anticancer effects in many cell types, both alone and in combination with chemotherapy drugs, through binding to vitamin D receptor (VDR); however, the role of calcitriol in MPM is still unknown.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	175-193
33133014-2	2020	The biologically active form of vitamin D, calcitriol, exerts anticancer effects in many cell types, both alone and in combination with chemotherapy drugs, through binding to vitamin D receptor (VDR); however, the role of calcitriol in MPM is still unknown.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	195-198
31187385-10	2019	Expression of SNHG6 was correlated with vitamin D levels in male controls but no other subgroups (r = 0.51, P = 0.044).	Vitamin D	40-49	small nucleolar RNA host gene 6	Homo sapiens	14-19
33424090-10	2020	The concentration of anti-TPO and anti-TG antibodies were statistically significant higher in patients with vitamin D deficiency (p< 0,001).	Vitamin D	108-117	thyroid peroxidase	Homo sapiens	26-29
31359379-5	2019	In addition, lower level of vitamin D strongly increased the risk of CAD (15 +- 11.02 vs. 21.3 +- 18 mug/L, p = 0.043) and AMVC (12.1 +- 13.1 vs.21.3 +- 18 mug/L, p = 0.014) development in individuals carrying T/T genotype of VDBP 7041 T&gt;G gene polymorphism.	Vitamin D	28-37	GC vitamin D binding protein	Homo sapiens	226-230
32846212-8	2020	Moreover, the neuroprotective effects of vitamin D and dehydroepiandrosterone (DHEA) are mediated through the binding to vitamin D receptor (VDR) and several intracellular and membrane receptors, respectively.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	141-144
32936248-4	2020	Vitamin D deficiency was associated with increased aortic expression of osteopontin and matrix metalloproteinase-2 and -9 than controls.	Vitamin D	0-9	matrix metallopeptidase 2	Mus musculus	88-121
31359379-8	2019	Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G&gt;A and rs7T41&gt;G VDBP genes polymorphisms.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	129-132
31359379-8	2019	Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G&gt;A and rs7T41&gt;G VDBP genes polymorphisms.	Vitamin D	85-94	GC vitamin D binding protein	Homo sapiens	165-169
31548577-2	2019	CYP24A1 expression regulates cellular response to vitamin D, which has antitumor effects against breast cancer.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
31524100-7	2021	Results: Vitamin D supplementation significantly mitigated the observed aging-related reduction in brain BDNF level and activities of AChE and antioxidant enzymes and elevation in malondialdehyde level and caspase-3 activity compared to control groups.	Vitamin D	9-18	brain-derived neurotrophic factor	Rattus norvegicus	105-109
31524100-10	2021	Augmenting brain BDNF seems to be a key mechanism through which vitamin D counteracts age-related brain dysfunction.	Vitamin D	64-73	brain-derived neurotrophic factor	Rattus norvegicus	17-21
31583252-5	2019	Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients.	Vitamin D	172-181	7-dehydrocholesterol reductase	Homo sapiens	103-108
31583252-5	2019	Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients.	Vitamin D	172-181	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	127-134
31583252-5	2019	Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients.	Vitamin D	172-181	vitamin D receptor	Homo sapiens	140-143
31701079-9	2019	Our results suggest an upregulation of the VDR-1,25(OH)2D complex bioavailability in GDM-d placentas, possibly reflecting a compensatory mechanism aiming to ensure that vitamin D can exert its genomic and nongenomic effects in the target cells of the placental-fetal unit.	Vitamin D	169-178	vitamin D receptor	Homo sapiens	43-46
31261249-2	2019	The overproduction of fibroblast growth factor 23 causes a paraneoplastic syndrome characterized by hyperphosphaturia, hypophosphatemia, hypovitaminosis D, and vitamin D refractory rickets/osteomalacia, effects that disappear with tumor removal.	Vitamin D	160-169	fibroblast growth factor 23	Homo sapiens	22-49
31245891-0	2019	Vitamin D attenuates myocardial ischemia-reperfusion injury by inhibiting inflammation via suppressing the RhoA/ROCK/NF-kB pathway.	Vitamin D	0-9	ras homolog family member A	Rattus norvegicus	107-111
31591986-1	2019	BACKGROUND: The proposed role of Vitamin D Receptor (VDR) in various cancers underscores the importance of vitamin D compounds as a novel therapeutic agent in the prevention of occurrence and progression of cancer.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	33-51
31591986-1	2019	BACKGROUND: The proposed role of Vitamin D Receptor (VDR) in various cancers underscores the importance of vitamin D compounds as a novel therapeutic agent in the prevention of occurrence and progression of cancer.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	53-56
31446716-4	2019	There are certain specific associations between vitamin D and IL-33/ST2 in the pathogenesis of AR.	Vitamin D	48-57	ST2	Homo sapiens	68-71
31555149-3	2019	Active vitamin D mediates its function via the vitamin D receptor (Vdr), which is a ligand-activated transcription factor.	Vitamin D	7-16	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	47-65
31555149-3	2019	Active vitamin D mediates its function via the vitamin D receptor (Vdr), which is a ligand-activated transcription factor.	Vitamin D	7-16	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	67-70
31461904-3	2019	FGF23 is a bone-derived hormone that is essential for regulating vitamin D and phosphate homeostasis.	Vitamin D	65-74	fibroblast growth factor 23	Homo sapiens	0-5
33029399-0	2020	Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil).	Vitamin D	15-24	vitamin D receptor	Homo sapiens	59-62
33029399-4	2020	The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	4-7
33029399-4	2020	The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	114-132
33029399-4	2020	The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D.	Vitamin D	114-123	vitamin D receptor	Homo sapiens	4-7
33029399-5	2020	Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	161-164
32911690-6	2020	Interestingly, the increased IL-18 only decreased by vitamin D addition in endothelial cells but not in RPE cells, suggesting a main antiangiogenic role under inflammatory conditions.	Vitamin D	53-62	interleukin 18	Homo sapiens	29-34
32911795-2	2020	Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1alpha-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	300-318
32899460-2	2020	The depletion of vitamin D seems to play a role in the fragilization of old persons, and genetic polymorphisms of the vitamin D receptor (VDR) gene seem to be involved in regulating the vitamin D pathway.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	138-141
32899880-3	2020	However, the observation of seasonal changes in blood pressure and the subsequent identification of vitamin D receptor (VDR) and 1alpha-hydroxylase in cardiomyocytes, as well as endothelial and vascular smooth muscle cells, implicated a role of vitamin D in the cardiovascular system.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	120-123
32673820-7	2020	The AMP levels of GCF and gingival tissue in the vitamin D deficient group was lower compared to sufficient serum 25(OH)D within gingivitis and CP groups.	Vitamin D	49-58	guanylate cyclase 2F, retinal	Homo sapiens	18-21
32673820-9	2020	Regression analysis showed that the periodontal disease status, serum vitamin D concentration were independent predictors for elevated GCF AMP levels.	Vitamin D	70-79	guanylate cyclase 2F, retinal	Homo sapiens	135-138
32939414-11	2020	Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma.	Vitamin D	122-131	vitamin D receptor	Homo sapiens	59-62
32939414-11	2020	Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma.	Vitamin D	122-131	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	168-176
32939414-11	2020	Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma.	Vitamin D	202-211	vitamin D receptor	Homo sapiens	59-62
32705172-8	2020	In NEC mice, vitamin D reduced intestinal tissue damage, decreased the mRNA expression of IL-6, IL-1beta and TNF-alpha, and decreased the protein expression of cleaved caspase-3 and MDA.	Vitamin D	13-22	caspase 3	Mus musculus	168-177
32705172-9	2020	Whereas, vitamin D increased the protein expression of Bcl-2 and Ki67 and GPx, as well as the p-ERK1/2/ERK1/2 ratio, in NEC mice.	Vitamin D	9-18	antigen identified by monoclonal antibody Ki 67	Mus musculus	65-69
32867971-1	2020	It has been demonstrated that vitamin D (Vit D) included in diets offers a beneficial effect by improving innate immune responses in chickens.	Vitamin D	30-39	vitrin	Gallus gallus	41-44
32982979-6	2020	FGF23 acts on the kidneys through partner fibroblast growth factor receptors (FGFRs) and the co-receptor Klotho to promote phosphaturia via a downregulation of phosphate transporters, as well as the control of vitamin D metabolizing enzymes to reduce blood 1,25D.	Vitamin D	210-219	fibroblast growth factor 23	Homo sapiens	0-5
32855522-0	2021	The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials.	Vitamin D	14-23	fibroblast growth factor 23	Homo sapiens	27-54
32855522-2	2021	We therefore aimed to synthesize the evidence for the effect of vitamin D administration on circulating FGF23 concentrations.	Vitamin D	64-73	fibroblast growth factor 23	Homo sapiens	104-109
32855522-6	2021	The weighted mean difference in FGF23 in the vitamin D versus placebo group was +21 pg/ml (95% CI: 13-28 pg/ml; P < 0.001) with considerable heterogeneity among studies (I2 = 99%).	Vitamin D	45-54	fibroblast growth factor 23	Homo sapiens	32-37
32855522-8	2021	Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001).	Vitamin D	48-57	fibroblast growth factor 23	Homo sapiens	14-19
32855522-8	2021	Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001).	Vitamin D	69-78	fibroblast growth factor 23	Homo sapiens	14-19
32855522-8	2021	Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001).	Vitamin D	69-78	fibroblast growth factor 23	Homo sapiens	14-19
32855522-8	2021	Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001).	Vitamin D	69-78	fibroblast growth factor 23	Homo sapiens	14-19
32855522-10	2021	In conclusion, this meta-analysis of RCTs demonstrates that vitamin D administration of >2000 IU/d vitamin D or activated vitamin D significantly increased concentrations of the cardiovascular risk marker FGF23, especially in patients with end-stage kidney/heart failure.	Vitamin D	60-69	fibroblast growth factor 23	Homo sapiens	205-210
32855522-10	2021	In conclusion, this meta-analysis of RCTs demonstrates that vitamin D administration of >2000 IU/d vitamin D or activated vitamin D significantly increased concentrations of the cardiovascular risk marker FGF23, especially in patients with end-stage kidney/heart failure.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	205-210
32855522-10	2021	In conclusion, this meta-analysis of RCTs demonstrates that vitamin D administration of >2000 IU/d vitamin D or activated vitamin D significantly increased concentrations of the cardiovascular risk marker FGF23, especially in patients with end-stage kidney/heart failure.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	205-210
32982966-2	2020	The alpha-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism.	Vitamin D	119-128	klotho	Homo sapiens	10-16
32982966-2	2020	The alpha-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	45-72
32982966-2	2020	The alpha-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	74-79
32847384-0	2022	Methylation Status of VDR Gene and its Association with Vitamin D Status and VDR Gene Expression in Pediatric Tuberculosis Disease.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	22-25
32847384-2	2022	Therefore, we aimed to study the effect of vitamin D receptor (VDR) gene methylation on plasma vitamin D level and the expression of the VDR gene in children with active-TB disease.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	63-66
32847384-6	2022	The VDR hypermethylation is significantly associated with reduced vitamin D level and decreased expression level of VDR gene.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	4-7
32824958-0	2020	Relationships between Total, Free and Bioavailable Vitamin D and Vitamin D Binding Protein in Early Pregnancy with Neonatal Outcomes: A Retrospective Cohort Study.	Vitamin D	51-60	GC vitamin D binding protein	Homo sapiens	65-90
32829285-1	2020	Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer.	Vitamin D	266-275	transient receptor potential cation channel subfamily V member 6	Homo sapiens	0-40
32829285-1	2020	Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer.	Vitamin D	266-275	transient receptor potential cation channel subfamily V member 6	Homo sapiens	42-47
32764491-8	2020	These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway.	Vitamin D	173-182	7-dehydrocholesterol reductase	Homo sapiens	57-62
32764491-8	2020	These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway.	Vitamin D	173-182	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	79-86
32408752-6	2020	Furthermore, the significant negative correlation between vitamin D level and CD8+ cell percentage, PLT, CRP and D-dimers was seen.	Vitamin D	58-67	CD8a molecule	Homo sapiens	78-81
32628073-10	2020	Our findings suggest that 25OHD-Gluc, a vitamin D metabolite found in bile, induces VDR-mediated responses in the colon by crossing the apical membrane of the colon epithelium.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	84-87
32467291-7	2020	Ingenuity pathway analysis was performed to identify upstream regulators and downstream signaling pathway genes differentially regulated by vitamin D, including TP63 and vitamin D receptor (VDR) mediated canonical pathways in particular.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	170-188
32467291-7	2020	Ingenuity pathway analysis was performed to identify upstream regulators and downstream signaling pathway genes differentially regulated by vitamin D, including TP63 and vitamin D receptor (VDR) mediated canonical pathways in particular.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	190-193
32627899-4	2020	Vitamin D deficient (VitD-Def) subjects (25(OH)D3 level < 26 ng/mL) expressed significant downregulation of vitamin D receptor (VDR) on monocytes as compared to controls (P < .0001), and VDR expression was well-associated with serum 25(OH)D3 levels.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	108-126
32627899-4	2020	Vitamin D deficient (VitD-Def) subjects (25(OH)D3 level < 26 ng/mL) expressed significant downregulation of vitamin D receptor (VDR) on monocytes as compared to controls (P < .0001), and VDR expression was well-associated with serum 25(OH)D3 levels.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	128-131
32627899-4	2020	Vitamin D deficient (VitD-Def) subjects (25(OH)D3 level < 26 ng/mL) expressed significant downregulation of vitamin D receptor (VDR) on monocytes as compared to controls (P < .0001), and VDR expression was well-associated with serum 25(OH)D3 levels.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	187-190
32843916-4	2020	We review a role of the vitamin D signaling through its receptor of vitamin D receptor (Vdr) in these processes.	Vitamin D	24-33	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	68-86
32843916-4	2020	We review a role of the vitamin D signaling through its receptor of vitamin D receptor (Vdr) in these processes.	Vitamin D	24-33	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	88-91
32699341-7	2020	We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells.	Vitamin D	17-26	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	81-84
32686744-0	2020	The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	43-46
32686744-4	2020	The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	170-173
32660374-8	2021	The serum endocan level was found to be positively correlated with BMI and vitamin D levels in the BC group (p = 0.043 and p = 0.023, respectively).	Vitamin D	75-84	endothelial cell specific molecule 1	Homo sapiens	10-17
32664376-1	2020	BACKGROUND: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirectly via influencing the concentrations of biologically active vitamin D metabolites.	Vitamin D	191-200	GC vitamin D binding protein	Homo sapiens	12-37
32664376-1	2020	BACKGROUND: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirectly via influencing the concentrations of biologically active vitamin D metabolites.	Vitamin D	191-200	GC vitamin D binding protein	Homo sapiens	39-43
32635656-1	2020	Vitamin D is a fat-soluble vitamin that is metabolized by the liver into 25-hydroxyvitamin D [25(OH)D] and then by the kidney into 1,25-dihydroxyvitamin D [1,25(OH)2D], which activates the vitamin D receptor expressed in various cells, including immune cells, for an overall immunostimulatory effect.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	189-207
32251673-6	2020	Vitamin D promoted primary human ATII cells proliferation through the PI3K/AKT signaling pathway and activation of vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	115-133
32251673-6	2020	Vitamin D promoted primary human ATII cells proliferation through the PI3K/AKT signaling pathway and activation of vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	135-138
32251673-7	2020	Moreover, vitamin D inhibited EMT in response to TGF-beta, which was vitamin D receptor dependent.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	69-87
32513031-2	2020	FGF19 and FGF21 regulate bile acid and energy homeostasis, respectively, whereas FGF23 regulates vitamin D and phosphate homeostasis.	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	81-86
32605590-2	2020	Excess FGF23 activity leads to increased phosphate excretion in the kidneys - mediated by downregulation of renal tubular phosphate transporters - and reduced phosphate absorption in the intestines - due to impaired vitamin D activation.	Vitamin D	216-225	fibroblast growth factor 23	Homo sapiens	7-12
32655262-5	2020	Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action.	Vitamin D	63-72	fibroblast growth factor 23	Homo sapiens	0-27
32655262-5	2020	Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action.	Vitamin D	63-72	fibroblast growth factor 23	Homo sapiens	29-35
32452516-0	2020	Vitamin D-vitamin D receptor system downregulates expression of uncoupling proteins in brown adipocyte through interaction with hairless protein.	Vitamin D	0-9	HR, lysine demethylase and nuclear receptor corepressor	Rattus norvegicus	128-144
32560347-2	2020	Vitamin D deficiency has been largely associated with various types of solid and non-solid human cancers, and the almost ubiquitous expression of vitamin D receptor (VDR) has always led to suppose a crucial role of vitamin D in cancer.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	166-169
32553153-1	2020	Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues.	Vitamin D	91-100	GC vitamin D binding protein	Homo sapiens	0-25
32553153-1	2020	Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues.	Vitamin D	91-100	GC vitamin D binding protein	Homo sapiens	27-30
32553153-1	2020	Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues.	Vitamin D	91-100	GC vitamin D binding protein	Homo sapiens	70-81
32534577-0	2020	Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	20-23
32534577-5	2020	We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR).	Vitamin D	69-78	NAD synthetase 1	Homo sapiens	91-98
32534577-5	2020	We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR).	Vitamin D	69-78	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
32534577-5	2020	We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR).	Vitamin D	69-78	vitamin D receptor	Homo sapiens	121-124
32462983-2	2021	Vitamin D receptor (VDR) is a part of the nuclear receptor family exerts vitamin D activation to maintain calcium/phosphorous homeostasis and bone metabolism.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	0-18
32462983-2	2021	Vitamin D receptor (VDR) is a part of the nuclear receptor family exerts vitamin D activation to maintain calcium/phosphorous homeostasis and bone metabolism.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	20-23
32462983-3	2021	The reduction of VDR activity leads to vitamin D deficiency.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	17-20
31815524-7	2020	VD treatment elevated p-AMPK/AMPK and decreased p-mTOR/mTOR, and it increased LC3II/LC3I, increased the protein level of Beclin-1, but decreased p62 according to Western blot analysis.	Vitamin D	0-2	beclin 1	Homo sapiens	121-129
31815524-7	2020	VD treatment elevated p-AMPK/AMPK and decreased p-mTOR/mTOR, and it increased LC3II/LC3I, increased the protein level of Beclin-1, but decreased p62 according to Western blot analysis.	Vitamin D	0-2	nucleoporin 62	Homo sapiens	145-148
32102946-4	2020	We selected 21 SNPs in vitamin D-related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1, DHCR7, NADSYN1) to test genotype and genotype-treatment interactions in relation to prostate cancer.	Vitamin D	23-32	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	75-82
32102946-4	2020	We selected 21 SNPs in vitamin D-related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1, DHCR7, NADSYN1) to test genotype and genotype-treatment interactions in relation to prostate cancer.	Vitamin D	23-32	7-dehydrocholesterol reductase	Homo sapiens	93-98
30221569-2	2020	Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	0-18
30221569-2	2020	Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	20-23
30221569-3	2020	Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitamin D in pregnancy.	Vitamin D	95-104	vitamin D receptor	Homo sapiens	20-23
30221569-10	2020	By changing the expression and the activity of VDR gene, which leads to the change in expression of vitamin D-responsive genes, these polymorphisms and haplotypes could possibly have an effect on immune system in the female reproductive tract.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	47-50
32478379-1	2020	STUDY QUESTION: Is there any relationship between vitamin D [25 (OH) vitamin D], total plasma homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in women with recurrent pregnancy losses (RPL)?	Vitamin D	50-59	methylenetetrahydrofolate reductase	Homo sapiens	148-153
30789807-0	2020	Association Between Bat Vitamin D Receptor 3" Haplotypes and Vitamin D Levels at Baseline and a Lower Response After Increased Vitamin D Supplementation and Exposure to Sunlight.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	24-42
30789807-1	2020	Objective: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	166-169
31450606-3	2019	Epidemiological and genetic association studies demonstrate that VITD may have a protective role in AMD, while single nucleotide polymorphisms in the vitamin D metabolism gene (CYP24A1) increase the risk of AMD.	Vitamin D	150-159	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	177-184
30987555-0	2020	The Association between Vitamin D Deficiency and variants of Vitamin D Binding protein gene among Healthy Iranian Adults.	Vitamin D	24-33	GC vitamin D binding protein	Homo sapiens	61-86
30987555-2	2020	The aim of this study was to demonstrate that vitamin D deficiency may be due to variants of vitamin D binding protein (DBP) among otherwise healthy Iranian adults.	Vitamin D	46-55	GC vitamin D binding protein	Homo sapiens	93-118
31406210-4	2019	Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma.	Vitamin D	98-107	integrin subunit alpha M	Homo sapiens	135-140
31868234-2	2020	Binding of the active vitamin D metabolite, 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) to the vitamin D receptor (VDR) induces conformational changes in its C-terminal domain enabling competency for interaction with physiologically relevant coactivators, including SRC-1.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	93-111
31868234-2	2020	Binding of the active vitamin D metabolite, 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) to the vitamin D receptor (VDR) induces conformational changes in its C-terminal domain enabling competency for interaction with physiologically relevant coactivators, including SRC-1.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	113-116
32020783-8	2020	RESULTS: In activity-limited mice, vitamin D deficiency accelerated the decrease in GA muscle weight, muscle fiber CSA, and grip strength and increased the protein expression of MuRF1, MAFbx, and FOXO3a (all P &lt; 0.05).	Vitamin D	35-44	forkhead box O3	Mus musculus	196-202
31926498-0	2019	Serum Level of IL 10 is Significantly Increased in Allergic Rhinitis Patients on Subcutaneous Immunotherapy and Vitamin D Supplementation.	Vitamin D	112-121	interleukin 10	Homo sapiens	15-20
32097682-3	2020	It has been demonstrated, that vitamin D conjugates, linked via a hydroxyl group at C11, might be promising for the development of highly specific antibodies to be employed in competitive protein binding assays.	Vitamin D	31-40	RNA polymerase III subunit K	Homo sapiens	84-87
31926498-4	2019	Objective of this study was to assess role of Vitamin D supplementation with SCIT in inducing tolerance to pollen, increasing IL10 and improving symptoms in AR patients.	Vitamin D	46-55	interleukin 10	Homo sapiens	126-130
32283207-1	2020	Intestinal calcium (Ca) absorption depends upon vitamin D signaling through the vitamin D receptor (VDR) in the proximal and distal intestine while lower VDR content causes intestinal resistance to 1,25 dihydroxyvitamin D (1,25(OH)2 D) action.	Vitamin D	48-57	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	80-98
32283207-1	2020	Intestinal calcium (Ca) absorption depends upon vitamin D signaling through the vitamin D receptor (VDR) in the proximal and distal intestine while lower VDR content causes intestinal resistance to 1,25 dihydroxyvitamin D (1,25(OH)2 D) action.	Vitamin D	48-57	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	100-103
31926498-9	2019	In conclusion, serum level of IL 10 is significantly increased in AR patients on SCIT and Vitamin D supplementation.	Vitamin D	90-99	interleukin 10	Homo sapiens	30-35
31037817-1	2019	FGF-23 is a 32 kDa protein that is a key regulator of phosphorus and vitamin D metabolism.	Vitamin D	69-78	fibroblast growth factor 23	Homo sapiens	0-6
32278787-7	2020	The best affinity score (-11.0 kcal/mol) was obtained for flucythrinate with the nuclear receptor for vitamin D (VDR).	Vitamin D	102-111	vitamin D receptor	Homo sapiens	113-116
32536905-1	2020	Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	81-99
32536905-1	2020	Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	101-104
32443760-1	2020	Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM).	Vitamin D	54-63	GC vitamin D binding protein	Homo sapiens	0-25
32443760-1	2020	Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM).	Vitamin D	54-63	GC vitamin D binding protein	Homo sapiens	27-31
32546996-1	2020	Introduction: The vitamin D binding protein (VDBP, also known as GC-globulin) and vitamin D deficiency have been associated with chronic obstructive pulmonary disease (COPD).	Vitamin D	18-27	GC vitamin D binding protein	Homo sapiens	45-49
32546996-1	2020	Introduction: The vitamin D binding protein (VDBP, also known as GC-globulin) and vitamin D deficiency have been associated with chronic obstructive pulmonary disease (COPD).	Vitamin D	18-27	GC vitamin D binding protein	Homo sapiens	65-76
32455017-0	2020	Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy.	Vitamin D	76-85	mechanistic target of rapamycin kinase	Rattus norvegicus	14-18
32455017-9	2020	Conclusion: It has been concluded that vitamin D is a potent adjuvant therapy in treatment of DN via downregulation of mTOR gene expression, stimulation of autophagy, and antioxidant, anti-inflammatory, and hypotensive effects.	Vitamin D	39-48	mechanistic target of rapamycin kinase	Rattus norvegicus	119-123
31961707-0	2020	TGF-beta1 promotes vitamin D-induced prostaglandin E2 synthesis by upregulating vitamin D receptor expression in human granulosa-lutein cells.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	80-98
31961707-1	2020	There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	103-117
31961707-1	2020	There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	119-122
31961707-7	2020	Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells.	Vitamin D	87-92	vitamin D receptor	Homo sapiens	67-70
31870913-3	2020	The aim of this study was to evaluate the effect of maternal and neonatal VDR polymorphisms (ApaI, TaqI, BsmI, FokI, Tru9I) on maternal and neonatal vitamin D status.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	74-77
32405607-1	2020	Context: alphaKlotho is a hormone and co-receptor for fibroblast growth factor 23 (FGF23), a hormone that downregulates active vitamin D synthesis and promotes phosphate excretion.	Vitamin D	127-136	fibroblast growth factor 23	Homo sapiens	54-81
32405607-1	2020	Context: alphaKlotho is a hormone and co-receptor for fibroblast growth factor 23 (FGF23), a hormone that downregulates active vitamin D synthesis and promotes phosphate excretion.	Vitamin D	127-136	fibroblast growth factor 23	Homo sapiens	83-88
32049653-0	2020	Hereditary vitamin D-resistant rickets: a report of four cases with two novel variants in the VDR gene and successful use of intermittent intravenous calcium via a peripheral route.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	94-97
32049653-1	2020	Background Hereditary vitamin D-resistant rickets (HVDRR) is caused by vitamin D receptor (VDR) defects.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	71-89
32049653-1	2020	Background Hereditary vitamin D-resistant rickets (HVDRR) is caused by vitamin D receptor (VDR) defects.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	52-55
32344842-10	2020	Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (p < 0.05).	Vitamin D	186-195	TNF receptor superfamily member 1B	Homo sapiens	62-94
32344842-10	2020	Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (p < 0.05).	Vitamin D	186-195	TNF receptor superfamily member 1B	Homo sapiens	96-101
32344842-10	2020	Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (p < 0.05).	Vitamin D	186-195	interleukin 10	Homo sapiens	138-152
32344842-10	2020	Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (p < 0.05).	Vitamin D	186-195	interleukin 10	Homo sapiens	154-159
32045827-4	2020	Therefore, we investigated vitamin D-induced FGF23 production in osteocyte-like cells derived from MC3T3-E1 osteocyte progenitor cells.	Vitamin D	27-36	fibroblast growth factor 23	Mus musculus	45-50
32045827-5	2020	We also investigated differences in the induction of FGF23 by 1alpha,25-dihydroxyvitamin D and various vitamin D analogs.	Vitamin D	81-90	fibroblast growth factor 23	Mus musculus	53-58
32045827-9	2020	Therefore, the induction of FGF23 in osteocytes by vitamin D may be primarily mediated via VDR.	Vitamin D	51-60	fibroblast growth factor 23	Mus musculus	28-33
32045827-9	2020	Therefore, the induction of FGF23 in osteocytes by vitamin D may be primarily mediated via VDR.	Vitamin D	51-60	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	91-94
32045827-13	2020	Therefore, an appropriate vitamin D analog should be chosen for each patient with mineral and bone disorder, considering its effect on FGF23 production.	Vitamin D	26-35	fibroblast growth factor 23	Homo sapiens	135-140
32047095-6	2020	We also found suggestive cross-associated loci for neonatal and maternal vitamin D near immune genes, such as CXCL6-IL8 and ACKR1 We found no interactions with ASD.	Vitamin D	73-82	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	124-129
32355520-1	2020	To clarify the regulation of astragalus on the aging BMSCs model and the effect of astragalus on Vitamin D (VD)-FGF23-Klotho axis.	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	112-117
32355520-1	2020	To clarify the regulation of astragalus on the aging BMSCs model and the effect of astragalus on Vitamin D (VD)-FGF23-Klotho axis.	Vitamin D	97-106	klotho	Homo sapiens	118-124
31686401-1	2020	PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	162-180
31686401-1	2020	PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	182-185
31686401-1	2020	PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile.	Vitamin D	121-124	vitamin D receptor	Homo sapiens	162-180
31686401-1	2020	PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile.	Vitamin D	121-124	vitamin D receptor	Homo sapiens	182-185
31940280-1	2020	The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes.	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	152-170
31940280-1	2020	The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes.	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	172-175
31940280-1	2020	The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes.	Vitamin D	63-72	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	152-170
31940280-1	2020	The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes.	Vitamin D	63-72	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	172-175
31809868-13	2020	In addition, leptin downregulated CYP24A1 and upregulated CYP27B1, CYP27A1 and VDR, which play vital roles in vitamin D metabolism.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	79-82
31881310-2	2020	Transepithelial intestinal Ca absorption is mediated by 1,25-dihydroxyvitamin D (1,25(OH)2D, calcitriol) through the vitamin D receptor (VDR).	Vitamin D	70-79	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	137-140
30965119-0	2019	Presence of the vitamin D inactivating enzyme CYP24A1 in human sperm and prediction of the success of intrauterine insemination: A prospective study.	Vitamin D	16-25	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	46-53
32489362-4	2020	Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	117-120
32489362-8	2020	However, the effect of VDR gene polymorphism on vitamin D levels was not found in patients of CSU.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	23-26
31982424-11	2020	Also, Vitamin D analogue significantly increased expression of Nrf2 and its downstream effectors (HO-1 and GSH), improved serum levels of total 25-hydroxyvitamin D and calcium, decreased neuro-inflammation and Amyloid beta load as well as hyperphosphorylation of MAPK-38, ERK1/2 and tau proteins were also observed.	Vitamin D	6-15	heme oxygenase 1	Rattus norvegicus	98-110
29300914-14	2019	Increased neurogenesis in klotho KO mice may be secondary to the activation of other pathways altered in the model, such as vitamin D.	Vitamin D	124-133	klotho	Mus musculus	26-32
32213983-5	2020	They were rapidly induced (4-6 h) upon VDR activation by 10 nM VitD or 100 microM lithocholic acid (LCA).	Vitamin D	63-67	vitamin D receptor	Homo sapiens	39-42
31177749-10	2019	The median (P(25), P(75)) serum vitamin D was 16.0 (13.5, 18.5) and 17.4 (14.3, 20.5) ng/ml, respectively.	Vitamin D	32-41	tubulin polymerization promoting protein	Homo sapiens	12-17
32208427-12	2020	Stress fracture risk in RM recruits is impacted by the interaction of VDR genotype with vitamin D status.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	70-73
32051143-0	2020	Vitamin D receptor targets hepatocyte nuclear factor 4alpha and mediates protective effects of vitamin D in nonalcoholic fatty liver disease.	Vitamin D	95-104	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
30903715-10	2019	In vitro analysis showed that adding different concentrations of active vitamin D increased the Treg/Th17 ratio, also the mRNA levels of the vitamin D receptor and the metabolic enzyme CYP24A1 increased significantly.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	141-159
32051143-6	2020	Liver-specific VDR deletion significantly exacerbated HFD- or MCD-induced hepatic steatosis and insulin resistance and also diminished the protective effect of vitamin D supplementation on NAFLD.	Vitamin D	160-169	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	15-18
32051143-8	2020	These results suggest that vitamin D ameliorates NAFLD and metabolic abnormalities by activating hepatic VDR, leading to its interaction with HNF4alpha.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	105-108
32051143-8	2020	These results suggest that vitamin D ameliorates NAFLD and metabolic abnormalities by activating hepatic VDR, leading to its interaction with HNF4alpha.	Vitamin D	27-36	hepatic nuclear factor 4, alpha	Mus musculus	142-151
32051143-9	2020	Our findings highlight a potential value of using vitamin D for preventing and managing NAFLD by targeting VDR.	Vitamin D	50-59	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	107-110
30903715-10	2019	In vitro analysis showed that adding different concentrations of active vitamin D increased the Treg/Th17 ratio, also the mRNA levels of the vitamin D receptor and the metabolic enzyme CYP24A1 increased significantly.	Vitamin D	72-81	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	185-192
32184381-0	2020	Correction: Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3.	Vitamin D	12-21	lipocalin 2	Homo sapiens	103-107
31028080-6	2019	Analysis of the VDR cistrome in RWPE1 prostate epithelial cells revealed vitamin D-mediated regulation of multiple cancer-relevant pathways.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	16-19
32184381-0	2020	Correction: Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3.	Vitamin D	12-21	ribosomal protein S3	Homo sapiens	155-159
32183826-2	2020	This study was designed to assess how expression of the endometrial vitamin D receptor (VDR) and CYP27B1, a vitamin D metabolizing enzyme, change during the menstrual cycle in women of reproductive age.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	88-91
32183826-9	2020	In addition, serum vitamin D levels were positively correlated with VDR and HOXA10 protein levels in the endometrium.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	68-71
30905091-1	2019	BACKGROUND: Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	63-81
31255367-3	2020	The aim of this study was to examine the association between vitamin D status and circulating Lp-PLA2 levels in subjects with type 2 diabetes mellitus.	Vitamin D	61-70	phospholipase A2 group VII	Homo sapiens	94-101
31255367-7	2020	The vitamin D insufficiency group had higher serum LP-PLA2 levels than the vitamin D sufficiency group (t=-2.765, p=.005).	Vitamin D	4-13	phospholipase A2 group VII	Homo sapiens	51-58
31255367-8	2020	A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=-0.364, p=0.009).	Vitamin D	80-89	phospholipase A2 group VII	Homo sapiens	53-60
30905091-1	2019	BACKGROUND: Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	83-86
31940245-2	2020	The biological actions of vitamin D are carried out via the binding of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3) to the vitamin D receptor (VDR).	Vitamin D	26-35	vitamin D receptor	Homo sapiens	119-137
30905091-5	2019	VDR chromatin immunoprecipitation-sequencing was performed to identify vitamin D genomic targets in primary prostate epithelial cells.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	0-3
31940245-2	2020	The biological actions of vitamin D are carried out via the binding of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3) to the vitamin D receptor (VDR).	Vitamin D	26-35	vitamin D receptor	Homo sapiens	139-142
31940245-10	2020	In summary, we highlight a direct role for the VDR in regulating skeletal muscle mitochondrial respiration in vitro, providing a potential mechanism as to how vitamin D deficiency might impact upon skeletal muscle oxidative capacity.	Vitamin D	159-168	vitamin D receptor	Homo sapiens	47-50
31179282-1	2019	Vitamin D possesses renoprotective effects beyond mineral metabolism, potentially reducing arterial blood pressure and inflammation and vitamin D enzymes (CYP24A1 and CYP27B1) as well as vitamin D receptor (VDR) contribute to its homeostasis.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	155-162
31179282-1	2019	Vitamin D possesses renoprotective effects beyond mineral metabolism, potentially reducing arterial blood pressure and inflammation and vitamin D enzymes (CYP24A1 and CYP27B1) as well as vitamin D receptor (VDR) contribute to its homeostasis.	Vitamin D	136-145	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	155-162
31241425-8	2020	After UM, the significant up-regulation of TNF-alpha and hsa-miR-155 and down-regulation of IL-1beta were observed in the group with vitamin D supplementation.	Vitamin D	133-142	microRNA 155	Homo sapiens	61-68
31191300-11	2019	Our data indicate that supplementation with vitamin D may reduce systemic inflammation and when combined with surgery and early postsurgical rehabilitation, it may decrease the intensity of pain in LBP patients undergoing PLIF.	Vitamin D	44-53	lipopolysaccharide binding protein	Homo sapiens	198-201
31544572-5	2020	Vitamin D3 supplementation with HFD significantly increased the exploration of the novel object and the discrimination index and attenuated the alterations in the prefrontal cortex CAT and Achase expression.Conclusions: The present findings support the potential effect of vitamin D on recognition memory and cholinergic transmission in the prefrontal cortex and add to the pathophysiology of HFD consumption.	Vitamin D	273-282	choline O-acetyltransferase	Rattus norvegicus	181-184
31587178-3	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) acts as an anti-proliferative agent in human cancer by inhibiting the Wnt/beta-catenin pathway through the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	188-206
31587178-3	2020	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) acts as an anti-proliferative agent in human cancer by inhibiting the Wnt/beta-catenin pathway through the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	208-211
31191300-12	2019	Data indicate that LBP patients undergoing spine surgery should use vitamin D perioperatively as a supplement.	Vitamin D	68-77	lipopolysaccharide binding protein	Homo sapiens	19-22
31682937-0	2020	Inhibition of Niemann-Pick C1-like protein 1 by ezetimibe reduces uptake of deuterium-labeled vitamin D in mice.	Vitamin D	94-103	NPC1 like intracellular cholesterol transporter 1	Mus musculus	14-44
31108908-4	2019	Thus, the aims of this study were to examine the muscle function following administration of high doses of vitamin D.	Vitamin D	107-116	histocompatibility 40	Mus musculus	93-97
31682937-2	2020	Recent data from in vitro experiments have described Niemann-Pick C1-like protein 1 (Npc1l1) as an important sterol transporter for vitamin D absorption.	Vitamin D	132-141	NPC1 like intracellular cholesterol transporter 1	Mus musculus	53-83
31682937-2	2020	Recent data from in vitro experiments have described Niemann-Pick C1-like protein 1 (Npc1l1) as an important sterol transporter for vitamin D absorption.	Vitamin D	132-141	NPC1 like intracellular cholesterol transporter 1	Mus musculus	85-91
31682937-13	2020	To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.	Vitamin D	76-85	NPC1 like intracellular cholesterol transporter 1	Mus musculus	13-19
31682937-13	2020	To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.	Vitamin D	76-85	NPC1 like intracellular cholesterol transporter 1	Mus musculus	118-124
31972209-0	2020	The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway.	Vitamin D	61-70	heme oxygenase 1	Rattus norvegicus	137-141
31108908-12	2019	HIGH animals consumed significantly more food than the CON animals, such that they ingested more than a year"s worth of vitamin D in four weeks.	Vitamin D	120-129	histocompatibility 40	Mus musculus	0-4
31134092-5	2019	The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	243-246
32127758-3	2020	It is not yet clear whether the level of vitamin D and its receptor, vitamin D receptor (VDR), in the blood are helpful factors in the diagnosis of CRC.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	89-92
31134092-5	2019	The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	243-246
32102680-6	2020	DISCUSSION: We hypothesize that vitamin D and magnesium co-supplementation may provide a new adjuvant therapy through modulation of BDNF, inflammation, and SIRT1 in obese women.	Vitamin D	32-41	brain derived neurotrophic factor	Homo sapiens	132-136
32102680-6	2020	DISCUSSION: We hypothesize that vitamin D and magnesium co-supplementation may provide a new adjuvant therapy through modulation of BDNF, inflammation, and SIRT1 in obese women.	Vitamin D	32-41	sirtuin 1	Homo sapiens	156-161
31134092-6	2019	VDR is known to regulate the expression of more than 200 genes across a wide array of tissues in the human body and may play a role in controlling the Vitamin D levels.	Vitamin D	151-160	vitamin D receptor	Homo sapiens	0-3
31134092-7	2019	Moreover, reduced Vitamin D level and downregulation of VDR have been linked to gut dysbiosis, highlighting an intriguing role for the gut microbiome in the Vitamin D metabolism.	Vitamin D	157-166	vitamin D receptor	Homo sapiens	56-59
30730049-2	2019	The vitamin D receptor (VDR) has a crucial role in the pathogenesis of this disease because it mediates the functions of vitamin D in the immune system.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
31926093-1	2020	Background Hereditary vitamin D resistant rickets (HVDRR) is a bone disorder characterized by a phenotype of rickets with onset at early stage of life with elevated alkaline phosphatase, hypocalcemia, hypophosphatemia, hyperparathyroidism and elevated levels of 1,25-dihydroxyvitamin D (calcitriol) as a consequence of the resistance of the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	341-359
31926093-1	2020	Background Hereditary vitamin D resistant rickets (HVDRR) is a bone disorder characterized by a phenotype of rickets with onset at early stage of life with elevated alkaline phosphatase, hypocalcemia, hypophosphatemia, hyperparathyroidism and elevated levels of 1,25-dihydroxyvitamin D (calcitriol) as a consequence of the resistance of the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	52-55
32102427-7	2020	There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample.	Vitamin D	70-79	TNF receptor superfamily member 1B	Homo sapiens	59-65
30813741-1	2019	BACKGROUND: Fibroblast growth factor 23 (FGF23), a potent regulator of phosphate and vitamin D metabolism, is a new biomarker of kidney, bone and cardiovascular disorders.	Vitamin D	85-94	fibroblast growth factor 23	Homo sapiens	12-39
32042037-2	2020	A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	143-146
30813741-1	2019	BACKGROUND: Fibroblast growth factor 23 (FGF23), a potent regulator of phosphate and vitamin D metabolism, is a new biomarker of kidney, bone and cardiovascular disorders.	Vitamin D	85-94	fibroblast growth factor 23	Homo sapiens	41-46
32042037-2	2020	A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS.	Vitamin D	124-133	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	162-169
31001917-2	2019	We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC).	Vitamin D	92-101	vitamin D receptor	Homo sapiens	62-65
32033527-0	2020	Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.	Vitamin D	0-9	sirtuin 1	Homo sapiens	35-40
32033527-1	2020	BACKGROUND: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-gamma coactivator 1alpha (PGC-1alpha) and irisin levels and these improvements may reduce insulin resistance (IR).	Vitamin D	12-21	sirtuin 1	Homo sapiens	40-49
32033527-1	2020	BACKGROUND: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-gamma coactivator 1alpha (PGC-1alpha) and irisin levels and these improvements may reduce insulin resistance (IR).	Vitamin D	12-21	sirtuin 1	Homo sapiens	51-56
32033527-2	2020	The aim was to assess the effects of vitamin D supplementation on SIRT1, irisin, and IR in overweight/obese type 2 diabetes (T2D) patients.	Vitamin D	37-46	sirtuin 1	Homo sapiens	66-71
31642155-5	2020	Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	67-70
30714636-4	2019	Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	36-54
31651575-7	2020	Secondary analyses suggest that the effect of Vitamin D on post-MVC pain outcomes may be influenced by genetic variation in IL-10 and NLRP3.	Vitamin D	46-55	interleukin 10	Homo sapiens	124-129
32013162-0	2020	Vitamin D Supplementation Is Associated with Increased Glutathione Peroxidase-1 Levels in Arab Adults with Prediabetes.	Vitamin D	0-9	glutathione peroxidase 1	Homo sapiens	55-79
32013162-2	2020	This interventional study aimed to investigate the effects of vitamin D supplementation on glutathione peroxidase 1 (GPx1) levels and other parameters in Arab adults with prediabetes.	Vitamin D	62-71	glutathione peroxidase 1	Homo sapiens	91-115
32013162-2	2020	This interventional study aimed to investigate the effects of vitamin D supplementation on glutathione peroxidase 1 (GPx1) levels and other parameters in Arab adults with prediabetes.	Vitamin D	62-71	glutathione peroxidase 1	Homo sapiens	117-121
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	256-259
30714636-4	2019	Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	71-89
30714636-4	2019	Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-94
31998239-1	2019	Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	58-83
30714636-12	2019	In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	55-58
30714636-12	2019	In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	118-121
30889441-2	2019	Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes.	Vitamin D	35-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	46-64
30654105-0	2019	Mammary-specific ablation of Cyp24a1 inhibits development, reduces proliferation and increases sensitivity to vitamin D.	Vitamin D	110-119	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	29-36
31614180-12	2020	At E14, the osteoblasts started to express the receptor for activated vitamin D (VDR).	Vitamin D	70-79	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	81-84
30654105-7	2019	In summary, Cyp24a1 within MECs plays an important role in modulating postnatal and pregnancy-associated mammary gland development which provides support for inhibiting CYP24 A1 as a potential approach to activating the vitamin D pathway in breast cancer prevention and therapy.	Vitamin D	220-229	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	12-19
31312865-1	2020	This special issue article will focus on morphologic and functional roles of vitamin D in muscle, from strength to contraction to development and ageing and will characterise the controversy of VDR"s expression in skeletal muscle, central to our understanding of vitamin D"s effects on this tissue.	Vitamin D	263-272	vitamin D receptor	Homo sapiens	194-197
30654105-7	2019	In summary, Cyp24a1 within MECs plays an important role in modulating postnatal and pregnancy-associated mammary gland development which provides support for inhibiting CYP24 A1 as a potential approach to activating the vitamin D pathway in breast cancer prevention and therapy.	Vitamin D	220-229	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	169-177
30690074-0	2019	Vitamin D (1,25(OH)2D3) induces alpha-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.	Vitamin D	0-9	interleukin 10	Homo sapiens	120-125
30983779-1	2019	Background: Vitamin D, an important hormone required by the body, exerts its biological effects through Vitamin D receptors (VDRs) present on target cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	104-123
32497792-1	2020	BACKGROUND: Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome.	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	50-68
32497792-1	2020	BACKGROUND: Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome.	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	70-73
31006279-2	2020	The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	65-83
30983779-15	2019	Conclusions: The study determined Vitamin D Receptors (VDR) in PDL tissue after supplementation of Vitamin D.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	55-58
31006279-2	2020	The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	85-88
30606768-10	2019	Collectively, these data show that the VDR and FBW7 are mutual cofactors, and provide a mechanistic basis for the cancer-preventive actions of vitamin D.	Vitamin D	143-152	vitamin D receptor	Homo sapiens	39-42
30606768-11	2019	IMPLICATIONS: The key findings show that the VDR and the E3 ligase FBW7 regulate each other"s functions in transcriptional regulation and control of protein turnover, respectively, and provide a molecular basis for cancer-preventive actions of vitamin D.Visual Overview: http://mcr.aacrjournals.org/content/17/3/709/F1.large.jpg.	Vitamin D	244-253	vitamin D receptor	Homo sapiens	45-48
32013346-0	2020	Vitamin D - Deglycosylated Vitamin D Binding Protein Dimer: Positive Synergistic Effects on Recognition, Activation, Phagocytosis and Oxidative Stress on Macrophages.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	27-52
32013346-7	2020	25(OH) vitamin D levels of VDBP (20.7 nmol/mg; p < 0.001) and dgVDBP (28.8 +/- 3.9 nmol/mL; p < 0.001) was significantly lower than of VitD~dgVDBP (324.0 +/- 12.8 nmol/mL).	Vitamin D	7-16	GC vitamin D binding protein	Homo sapiens	27-31
32013346-11	2020	CONCLUSIONS: VitD~dgVDBP (Il-42) showed higher macrophage activation and lower oxidative burst than VitD free dgVDBP (GcMaf) and VDBP (Gc) which may result from a synergistic effect by presenting protein bound Vitamin D better to macrophages.	Vitamin D	210-219	GC vitamin D binding protein	Homo sapiens	20-24
30796319-7	2019	The associations among DHCR7, vitamin D and lipid profile followed a seasonal pattern, decreased DHCR7 (p = 0.008) and vitamin D (p < 0.001) and increased total-cholesterol (p = 0.025) being found in winter/spring.	Vitamin D	119-128	7-dehydrocholesterol reductase	Homo sapiens	23-28
30295181-1	2020	Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium.	Vitamin D	213-222	cubilin	Homo sapiens	0-5
30295181-1	2020	Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium.	Vitamin D	213-222	cubilin	Homo sapiens	6-43
30295181-1	2020	Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium.	Vitamin D	213-222	cubilin	Homo sapiens	53-57
30796319-8	2019	Increasing vitamin D upon TNFalpha-blockade paralleled RA clinical improvement (r = -0.610, p = 0.027) and DHCR7 elevation (r = 0.766, p = 0.002).	Vitamin D	11-20	7-dehydrocholesterol reductase	Homo sapiens	107-112
32504501-4	2020	PURPOSE OF REVIEW: This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central nervous system.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	178-181
30796319-9	2019	In conclusion, vitamin D-related polymorphisms and DHCR7 are pivotal to understand the complex, seasonal associations between vitamin D and lipid profile in RA.	Vitamin D	126-135	7-dehydrocholesterol reductase	Homo sapiens	51-56
30778159-9	2019	Although 1,25(OH)2D and 24,25(OH)2D are decreased in CKD patient serum, our findings suggest that PTH and FGF23 retain their effects to regulate vitamin D metabolism even in the kidneys of these patients, while production of 1,25(OH)2D and 24,25(OH)2D from 25(OH)D is restricted due to either impairment of megalin-mediated reabsorption of the 25(OH)D-DBP complex or reduced renal mass.	Vitamin D	145-154	fibroblast growth factor 23	Homo sapiens	106-111
30287151-3	2019	Vitamin D exerts its pharmacological effects primarily via vitamin D receptor, whose activation inhibits the renin-angiotensin system, a key culprit for DN under hyperglycemia.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	59-77
30287151-5	2019	Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES).	Vitamin D	129-138	C-C motif chemokine ligand 5	Homo sapiens	525-531
30760247-13	2019	CONCLUSIONS: Our preliminary data showed that the levels of the vitamin D-related cytokines IL-15 and IL-32 differed between active TB patients and LTBI subjects.	Vitamin D	64-73	interleukin 15	Homo sapiens	92-97
31557081-0	2020	NOVEL VDR MUTATIONS IN PATIENTS WITH VITAMIN D-DEPENDENT RICKETS TYPE 2A: A MILD DISEASE PHENOTYPE CAUSED BY A NOVEL CANONICAL SPLICE-SITE MUTATION.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	6-9
30317548-3	2019	The aim of this study was to establish whether high-dose vitamin D supplementation reduces serum levels of NFL.	Vitamin D	57-66	neurofilament light chain	Homo sapiens	107-110
31557081-1	2020	Objective: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor gene (VDR), leading to end-organ resistance to 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	122-140
31557081-1	2020	Objective: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor gene (VDR), leading to end-organ resistance to 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	147-150
30317548-8	2019	In the subgroup of patients not receiving disease-modifying therapy, NFL decreased by 30.9% to week 48% and 32.6% to week 96 from baseline in the vitamin D group as compared to the placebo group (P = 0.06 for both time points).	Vitamin D	146-155	neurofilament light chain	Homo sapiens	69-72
30578920-0	2019	Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice.	Vitamin D	34-43	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	77-84
31792684-3	2020	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	162-180
31792684-3	2020	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	182-185
31792684-3	2020	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR).	Vitamin D	70-79	vitamin D receptor	Homo sapiens	162-180
31792684-3	2020	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR).	Vitamin D	70-79	vitamin D receptor	Homo sapiens	182-185
30145365-3	2019	OBJECTIVES: To investigate associations of PUFA plasma levels and dietary intake with asthma and allergy at age 3 years in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial.	Vitamin D	151-160	pumilio RNA binding family member 3	Homo sapiens	43-47
31792685-6	2020	FGF23 also decreases 1,25-dihydroxyvitamin D levels by regulating the expression of vitamin D-metabolizing enzymes, which results in reduced intestinal phosphate absorption.	Vitamin D	35-44	fibroblast growth factor 23	Homo sapiens	0-5
31792685-9	2020	These results indicate that FGF23 is a physiological regulator of phosphate and vitamin D metabolism and indispensable for the maintenance of serum phosphate levels.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	28-33
31124381-0	2020	Effect of Cholecalciferol Supplementation on Treatment Response and IL-10 Level in Vitamin D Deficient Parthenium Dermatitis Patients: A Randomized Double-Blind Placebo-Controlled Trial.	Vitamin D	83-92	interleukin 10	Homo sapiens	68-73
31124381-8	2020	The relatively higher increase in IL-10 level observed in the vitamin D group was statistically insignificant compared to placebo group.	Vitamin D	62-71	interleukin 10	Homo sapiens	34-39
30145365-11	2019	Antenatal vitamin D could modulate the effect of early childhood PUFA on risk of asthma and allergy.	Vitamin D	10-19	pumilio RNA binding family member 3	Homo sapiens	65-69
31740231-1	2020	CYP24A1, an essential gene in regulation of vitamin D, has been reported to play an important role in enhancing immune activity and inhibiting tumorigenesis.	Vitamin D	44-53	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
30278216-2	2019	Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	115-133
33211920-7	2020	A survey of pregnant women was conducted and the maternal serum total vitamin D [25 (OH) D2 and D3] level was determined by enzyme immunoassay.	Vitamin D	70-79	immunoglobulin heavy diversity 2-15	Homo sapiens	89-98
30278216-2	2019	Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	135-138
32368685-1	2019	Introduction: The biological actions of vitamin D are mediated through vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	71-89
30278216-2	2019	Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	232-235
32368685-1	2019	Introduction: The biological actions of vitamin D are mediated through vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	91-94
30278216-2	2019	Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	135-138
32844632-0	2020	[Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region].	Vitamin D	21-30	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	54-61
30278216-2	2019	Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	232-235
32844632-3	2020	OBJECTIVE: To evaluate the relationship between vitamin D status and polymorphisms of the genes encoding enzymes of the vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) in patients with MS. MATERIAL AND METHODS: Caucasians born and living in the Altai region of the Russian Federation, 90 patients with relapsing-remitting MS and 87 volunteers without MS took part in the study.	Vitamin D	48-57	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	164-171
31389312-3	2019	Since the vitamin D receptor (VDR) is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	30-33
31599948-1	2019	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone involved in the control of phosphate (P) homeostasis and vitamin D metabolism.	Vitamin D	119-128	fibroblast growth factor 23	Mus musculus	0-27
31532316-9	2019	Immune histochemical examination showed homogenous distribution of vitamin D and VDR expression in syncytiotrophoblasts, cytotrophoblasts and chorion villus stroma.Vitamin D expression relative area was 10,3% which is statistically different from the induced abortion group - 15,4% (p<0,01).	Vitamin D	164-173	vitamin D receptor	Homo sapiens	81-84
31599948-1	2019	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone involved in the control of phosphate (P) homeostasis and vitamin D metabolism.	Vitamin D	119-128	fibroblast growth factor 23	Mus musculus	29-34
31541729-1	2019	During our ongoing studies of vitamin D, we focused on the vitamin D3 side-chain 24-position, which is the major metabolic site of human CYP24A1.	Vitamin D	30-39	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	137-144
31532316-13	2019	Also in missed abortion group, positively significant correlation has been determined between the level of vitamin D in blood and VDR relative area expression (r = 0,412).	Vitamin D	107-116	vitamin D receptor	Homo sapiens	130-133
31061278-4	2019	The in vivo study showed vitamin D deficiency increased the expressions of MMP-9 and MMP-13 in rat articular cartilage, and the increase was inhibited by 1alpha,25(OH)2D3 supplementation.	Vitamin D	25-34	matrix metallopeptidase 9	Rattus norvegicus	75-80
31465293-0	2019	The role of vitamin D replacement therapy in serum FGF23 concentration in children with myelomeningocele compared with healthy children - a preliminary study.	Vitamin D	12-21	fibroblast growth factor 23	Homo sapiens	51-56
31465293-1	2019	Background Fibroblast growth factor 23 (FGF23) is a recently discovered bone-derived regulator of vitamin D metabolism and phosphate homeostasis.	Vitamin D	98-107	fibroblast growth factor 23	Homo sapiens	11-38
31465293-1	2019	Background Fibroblast growth factor 23 (FGF23) is a recently discovered bone-derived regulator of vitamin D metabolism and phosphate homeostasis.	Vitamin D	98-107	fibroblast growth factor 23	Homo sapiens	40-45
31061278-4	2019	The in vivo study showed vitamin D deficiency increased the expressions of MMP-9 and MMP-13 in rat articular cartilage, and the increase was inhibited by 1alpha,25(OH)2D3 supplementation.	Vitamin D	25-34	matrix metallopeptidase 13	Rattus norvegicus	85-91
31465293-4	2019	We aimed to investigate the influence of vitamin D replacement therapy on serum FGF23 concentration in children with MMC and compare the results with healthy participants.	Vitamin D	41-50	fibroblast growth factor 23	Homo sapiens	80-85
31465293-10	2019	In MMC children we found a significant decrease in median serum FGF23 after vitamin D replacement therapy (from 42.1 to 0 RU/mL, p < 0.001).	Vitamin D	76-85	fibroblast growth factor 23	Homo sapiens	64-69
31061278-7	2019	Thus, vitamin D intake may inhibit MMP activities and take part in the process of articular cartilage degeneration and osteoarthritis progression.	Vitamin D	6-15	matrix metallopeptidase 9	Rattus norvegicus	35-38
31465293-15	2019	Vitamin D replacement therapy decreases FGF23 concentrations in MMC children, although further studies are still warranted to gain detailed insight on the FGF23 in the MMC population.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	40-45
32040900-5	2019	The concentrations of secretory immunoglobulin A, lipopolysaccharide, binding protein and the level of total antioxidant activity are reduced in the oral fluid of people with vitamin D deficiency, but the number of intermediate products of lyoperoxidation increases.	Vitamin D	175-184	lipopolysaccharide binding protein	Homo sapiens	50-85
31731733-9	2019	Moreover, the studies for an adopted vitamin D supplementation due to breast cancer focality type must be enlarged to fully comprehend the remarkable and interesting role played by the vitamin D receptor.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	185-203
31769259-9	2019	Excessive 1,25(OH)2D3 formation in klotho-deficient NH4Cl-treated mice leads to an amazing surge of exploratory behavior, lack of anxiety and decreased depression, effects dissipated by low vitamin D diet.	Vitamin D	190-199	klotho	Mus musculus	35-41
31589177-6	2019	Genetic and experimental evidence suggests that vitamin D and the vitamin D receptor (VDR) may influence the gut microbiome in health and disease.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	86-89
30557404-3	2018	In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0.28); p21 expression alone and relative to mib-1 expression increased 29% (P = 0.06) and 73% (P = 0.06), respectively; and bax expression relative to mib-1 expression increased 58% (P = 0.21).	Vitamin D	7-16	MIB E3 ubiquitin protein ligase 1	Homo sapiens	114-119
30557404-6	2018	These pilot study results support further investigation of whether 1) vitamin D and calcium promote colorectal epithelial cell differentiation, reduce proliferation, and promote apoptosis in the normal-appearing human colorectal mucosa, 2) vitamin D and calcium act as chemopreventive agents against colorectal neoplasms, and 3) mib-1, p21, and bax are potential "treatable", pre-neoplastic, biomarkers of risk for colorectal neoplasms.	Vitamin D	240-249	MIB E3 ubiquitin protein ligase 1	Homo sapiens	329-334
30248338-3	2018	The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid.	Vitamin D	200-209	vitamin D receptor	Homo sapiens	95-98
30248338-3	2018	The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid.	Vitamin D	200-209	angiopoietin like 8	Homo sapiens	114-141
30248338-3	2018	The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid.	Vitamin D	200-209	angiopoietin like 8	Homo sapiens	143-150
30248338-3	2018	The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid.	Vitamin D	200-209	vitamin D receptor	Homo sapiens	182-185
30326825-7	2018	Vitamin D signaling pathway activation was evaluated by measuring the expression levels of VDR, CYP24A1, Tumor necrosis factor alpha (TNFalpha) and cathelicidin (CAMP) by qRT-PCR.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-94
30326825-7	2018	Vitamin D signaling pathway activation was evaluated by measuring the expression levels of VDR, CYP24A1, Tumor necrosis factor alpha (TNFalpha) and cathelicidin (CAMP) by qRT-PCR.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	96-103
30356853-7	2018	The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17.	Vitamin D	4-13	negative elongation factor complex member C/D	Homo sapiens	225-228
30356853-7	2018	The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17.	Vitamin D	151-160	negative elongation factor complex member C/D	Homo sapiens	225-228
30356853-7	2018	The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17.	Vitamin D	151-160	interleukin 10	Homo sapiens	310-315
30356853-7	2018	The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17.	Vitamin D	151-160	interleukin 17A	Homo sapiens	321-326
30405883-3	2018	In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D.	Vitamin D	54-63	7-dehydrocholesterol reductase	Homo sapiens	76-81
30405883-3	2018	In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D.	Vitamin D	156-165	7-dehydrocholesterol reductase	Homo sapiens	76-81
30405883-10	2018	In conclusion, DHCR7 rs12785878 and GC rs4588, but not CYP2R1 rs10741657, are significantly associated with vitamin D levels.	Vitamin D	108-117	7-dehydrocholesterol reductase	Homo sapiens	15-20
30286109-1	2018	The level of the vitamin D in the bloodstream is regulated by cytochrome P450 enzyme 24-hydroxylase A1 (CYP24A1).	Vitamin D	17-26	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	62-102
30286109-1	2018	The level of the vitamin D in the bloodstream is regulated by cytochrome P450 enzyme 24-hydroxylase A1 (CYP24A1).	Vitamin D	17-26	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
30286109-2	2018	Over expression of CYP24A1 enzyme is correlated with vitamin D deficiency and resistance to vitamin D therapy.	Vitamin D	53-62	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	19-26
30286109-2	2018	Over expression of CYP24A1 enzyme is correlated with vitamin D deficiency and resistance to vitamin D therapy.	Vitamin D	92-101	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	19-26
30286109-5	2018	Posner et al., (2010) first time reported two new vitamin D analogues namely CTA-091 and CTA-018 to inhibit CYP24A1.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	108-115
28913556-8	2018	Furthermore, vitamin D induced mRNA expression of TGF-beta (p = 0.048), TNF-alpha (p = 0.006) and PD-L1 (p = 0.02) and tended to induce IL-10 expression (p = 0.06).	Vitamin D	13-22	interleukin 10	Homo sapiens	136-141
28913556-9	2018	Multivariate factor analysis discriminated between pre- and post-vitamin D supplementation with a combined increased qPCR expression of PD1, PD-L1, TGF-beta, IL-10, CD80, CD86, FOXP3, NFATc2 and cathelicidin.	Vitamin D	65-74	interleukin 10	Homo sapiens	158-163
30233662-1	2018	It has been demonstrated that 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1) is a key enzyme that neutralizes vitamin D activity, which may have an anti-tumor effect.	Vitamin D	109-118	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	67-74
30233662-2	2018	Therefore, the aim of the current study was to explore the effect of the active metabolite of vitamin D, 1,25-dihydroxyvitamin D (1,25-D3) on thyroid cancer cells following the downregulation of CYP24A1.	Vitamin D	94-103	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	195-202
29964038-0	2018	Vitamin D Regulation of the Uridine Phosphorylase 1 Gene and Uridine-Induced DNA Damage in Colon in African Americans and European Americans.	Vitamin D	0-9	uridine phosphorylase 1	Mus musculus	28-51
29964038-2	2018	1alpha,25(OH)2D3 vitamin D (the active form of vitamin D) induces transcription of the uridine phosphorylase gene (UPP1) in colon tissues of European Americans but to a lesser extent in colon tissues of African Americans.	Vitamin D	17-26	uridine phosphorylase 1	Mus musculus	115-119
29964038-2	2018	1alpha,25(OH)2D3 vitamin D (the active form of vitamin D) induces transcription of the uridine phosphorylase gene (UPP1) in colon tissues of European Americans but to a lesser extent in colon tissues of African Americans.	Vitamin D	47-56	uridine phosphorylase 1	Mus musculus	115-119
30234384-3	2018	Vitamin D, a secosteroid hormone, interacts with its nuclear receptor vitamin D receptor (VDR) to regulate crucial biological processes, such as bone metabolism and immune function modulation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	70-88
30234384-3	2018	Vitamin D, a secosteroid hormone, interacts with its nuclear receptor vitamin D receptor (VDR) to regulate crucial biological processes, such as bone metabolism and immune function modulation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	90-93
30319189-3	2018	Therefore the present study was aimed to investigate the pattern of allelic variants of VDR gene polymorphism (FokI and BsmI), its influence on vitamin D levels and bone mineral density (BMD) in North Indian postmenopausal women with osteoporosis for possible genetic association.	Vitamin D	144-153	vitamin D receptor	Homo sapiens	88-91
29885880-9	2018	CONCLUSION: Calcipotriol induces local structure rearrangements in VDR that could possibly translate into a superior clinical potential to execute important non-classical vitamin D effects such as inhibition of HCV replication.	Vitamin D	171-180	vitamin D receptor	Homo sapiens	67-70
31729346-1	2018	Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	166-184
31034649-1	2019	The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 , and regulates various physiologic processes, such as bone and calcium metabolism, cellular proliferation and differentiation, and immunity.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
31729346-1	2018	Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	186-189
31729346-1	2018	Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor.	Vitamin D	120-129	vitamin D receptor	Homo sapiens	166-184
31729346-1	2018	Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor.	Vitamin D	120-129	vitamin D receptor	Homo sapiens	186-189
31351131-14	2019	CYP11B1 levels were also significantly increased by VitD treatment.	Vitamin D	52-56	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	0-7
30273386-7	2018	Our data suggest that the lack of vitamin D signalling in normocalcaemic vitamin D receptor mutants has no major detrimental effect on cardiac function and outcome post-myocardial infarction.	Vitamin D	34-43	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	73-91
31415769-1	2019	AIMS: Vitamin D and its receptor, vitamin D receptor (VDR), have renoprotection effect against diabetic nephropathy (DN).	Vitamin D	6-15	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	34-52
31415769-1	2019	AIMS: Vitamin D and its receptor, vitamin D receptor (VDR), have renoprotection effect against diabetic nephropathy (DN).	Vitamin D	6-15	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	54-57
29944852-8	2018	The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues.	Vitamin D	4-13	interleukin 17A	Mus musculus	101-106
31463983-9	2019	In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation.	Vitamin D	13-22	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	318-323
30271381-2	2018	Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis.	Vitamin D	48-57	sirtuin 1	Homo sapiens	0-9
30271381-2	2018	Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis.	Vitamin D	48-57	sirtuin 1	Homo sapiens	31-36
31557141-5	2019	Moreover, vitamin D supplementation seems to be effective in reducing the levels of thyroid peroxidase (TPO) antibodies both in patients with deficiency and with normal concentrations of vitamin D.	Vitamin D	10-19	thyroid peroxidase	Homo sapiens	84-102
31557141-5	2019	Moreover, vitamin D supplementation seems to be effective in reducing the levels of thyroid peroxidase (TPO) antibodies both in patients with deficiency and with normal concentrations of vitamin D.	Vitamin D	10-19	thyroid peroxidase	Homo sapiens	104-107
30271381-3	2018	Aim of the present study was to investigate common single nucleotide polymorphisms (SNP"s) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.	Vitamin D	246-255	sirtuin 1	Homo sapiens	179-187
31557141-5	2019	Moreover, vitamin D supplementation seems to be effective in reducing the levels of thyroid peroxidase (TPO) antibodies both in patients with deficiency and with normal concentrations of vitamin D.	Vitamin D	187-196	thyroid peroxidase	Homo sapiens	84-102
31557141-5	2019	Moreover, vitamin D supplementation seems to be effective in reducing the levels of thyroid peroxidase (TPO) antibodies both in patients with deficiency and with normal concentrations of vitamin D.	Vitamin D	187-196	thyroid peroxidase	Homo sapiens	104-107
30205552-1	2018	Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	61-79
31559105-4	2019	In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation, inflammation and fibrosis, to the vitamin D/vitamin D receptor (VD/VDR) axis, showing a strong association between hypovitaminosis D and the diagnosis of NAFLD.	Vitamin D	172-181	vitamin D receptor	Homo sapiens	205-208
30205552-1	2018	Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	81-84
31559105-4	2019	In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation, inflammation and fibrosis, to the vitamin D/vitamin D receptor (VD/VDR) axis, showing a strong association between hypovitaminosis D and the diagnosis of NAFLD.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	205-208
34025836-13	2021	In UC, higher vitamin D concentrations were associated with lower IL-17 concentrations.	Vitamin D	14-23	interleukin 17A	Homo sapiens	66-71
31508781-14	2019	Studies investigating the roles of vitamin D and LL-37 in the immune response and their associations with VDR polymorphisms and disease susceptibility are necessary.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	106-109
30316967-5	2019	Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D.	Vitamin D	163-172	NAD synthetase 1	Homo sapiens	95-102
30316967-5	2019	Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D.	Vitamin D	163-172	7-dehydrocholesterol reductase	Homo sapiens	103-108
30316967-5	2019	Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D.	Vitamin D	163-172	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	118-125
29183808-2	2018	Vitamin D exerts its genomic actions via the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D3 receptor	Cricetulus griseus	45-63
30887870-4	2019	Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients.	Vitamin D	125-134	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	86-92
30887870-4	2019	Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	94-97
30887870-8	2019	In addition, we identified gene-gene interactions between variants in genes KL, CYP27B1 and VDR related to vitamin D-metabolism and low-BMD in TS-patients.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	92-95
30371149-2	2018	Supplementation with active vitamin D has been proposed to have vasoprotective potential in CKD , not only by direct effects on the endothelium but also by an increment of alpha-Klotho.	Vitamin D	28-37	klotho	Homo sapiens	178-184
29782843-6	2018	At physiological concentrations, active vitamin D maintains a normal rate of bone resorption and formation through the RANKL/OPG signal.	Vitamin D	40-49	TNF superfamily member 11	Homo sapiens	119-124
29782843-6	2018	At physiological concentrations, active vitamin D maintains a normal rate of bone resorption and formation through the RANKL/OPG signal.	Vitamin D	40-49	basic transcription factor 3 pseudogene 11	Homo sapiens	125-128
29633705-2	2018	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism.	Vitamin D	100-109	fibroblast growth factor 23	Homo sapiens	0-27
29633705-2	2018	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism.	Vitamin D	100-109	fibroblast growth factor 23	Homo sapiens	29-34
29702263-5	2018	The purpose of this study was to examine the effects of vitamin D metabolites (VDM) on the expression of estrogen receptors (ERs), VDR, and 1OHase mRNA, and to evaluate the inhibitory effect of low doses of sorafenib in combination with cDtboc and VDM on cell proliferation in cultured human papillary thyroid carcinoma (PTC).	Vitamin D	56-65	vitamin D receptor	Homo sapiens	131-134
30200275-0	2018	Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	100-103
30200275-7	2018	On the other hand, the expression of VDR and its splicing variants and other vitamin D related genes (RXR, PDIA3, CYP3A4, CYP2R1, CYP27B1, CYP24A1 and CYP11A1) was detected in WM98 and A375 melanomas with the transcript levels being modulated by vitamin D analogs.	Vitamin D	77-86	retinoid X receptor alpha	Homo sapiens	102-105
30200275-7	2018	On the other hand, the expression of VDR and its splicing variants and other vitamin D related genes (RXR, PDIA3, CYP3A4, CYP2R1, CYP27B1, CYP24A1 and CYP11A1) was detected in WM98 and A375 melanomas with the transcript levels being modulated by vitamin D analogs.	Vitamin D	246-255	vitamin D receptor	Homo sapiens	37-40
30410834-3	2018	Due to the close association of vitamin D with the brain, it has been found that in the pathophysiology of several neuropsychiatric disorders vitamin D receptor (VDR) polymorphism plays a significant role.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	142-160
30410834-3	2018	Due to the close association of vitamin D with the brain, it has been found that in the pathophysiology of several neuropsychiatric disorders vitamin D receptor (VDR) polymorphism plays a significant role.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	162-165
30150667-1	2018	Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	140-158
30150667-1	2018	Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	160-163
30142216-4	2018	Therefore, we investigated the relationship between vitamin D levels and brain phenotypes in psychotic disorders, and assessed possible interactions with genetic variants in vitamin D receptor (VDR) and other genetic variants that play a role in vitamin D levels in the body.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	194-197
30107003-6	2018	The vitamin D receptor gene (VDR) was selected, and the interactions of genetic variation in VDR with circulating vitamin D levels and gemcitabine treatment were evaluated.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	29-32
31599133-9	2019	Conventional therapy for XLH and other disorders of FGF23-mediated hypophosphatemia involves multiple daily doses of oral phosphate salts and active vitamin D analogs, such as calcitriol or alfacalcidol.	Vitamin D	149-158	fibroblast growth factor 23	Homo sapiens	52-57
31434255-6	2019	We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9).	Vitamin D	133-142	cubilin	Homo sapiens	171-175
31434255-6	2019	We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9).	Vitamin D	133-142	nuclear receptor coactivator 7	Homo sapiens	177-182
31434255-6	2019	We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9).	Vitamin D	133-142	histone deacetylase 9	Homo sapiens	188-193
31300316-1	2019	Lithocholic acid (2) was identified as the second endogenous ligand of vitamin D receptor (VDR), though its binding affinity to VDR and its vitamin D activity are very weak compared to those of the active metabolite of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (1).	Vitamin D	71-80	vitamin D receptor	Homo sapiens	91-94
31395070-10	2019	CONCLUSIONS: Findings of this study showed that genetic variation in the VDR gene was associated with changes in cardio-metabolic parameters in breast cancer survivors, supplemented with vitamin D3, results could provide a novel insight into better understanding of which subset of individuals benefit most from normalization of vitamin D status.	Vitamin D	187-196	vitamin D receptor	Homo sapiens	73-76
30916559-5	2019	The nearly 150 crystal structures of VDR"s ligand-binding domain with various vitamin D compounds allow a detailed molecular understanding of their action.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	37-40
32542086-3	2020	Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated.	Vitamin D	55-64	klotho	Homo sapiens	165-171
32542086-3	2020	Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated.	Vitamin D	219-228	klotho	Homo sapiens	165-171
31043390-0	2019	Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	122-140
31043390-0	2019	Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	142-145
29575677-1	2018	The active form of vitamin D (1alpha,25-dihydroxyvitamin D) acts as a steroid hormone and binds to the vitamin D receptor.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	103-121
30321335-2	2019	Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	114-132
30321335-2	2019	Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	134-137
31125456-4	2019	Further, we demonstrate that the expression of CAII and CAIX in these cells is significantly up-regulated by the biologically active metabolites of vitamin A (all-trans retinoic acid) and vitamin D (1alpha,25-dihydroxyvitamin D3 ), respectively.	Vitamin D	188-197	carbonic anhydrase 2	Homo sapiens	47-51
30018005-0	2018	The impact of the vitamin D-modulated epigenome on VDR target gene regulation.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	51-54
31029431-14	2019	CONCLUSION(S): The VDR is expressed throughout the organs of reproduction, suggesting a role for vitamin D in reproduction.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	19-22
30018005-1	2018	The micronutrient vitamin D significantly modulates the human epigenome via enhancing genome-wide the rate of accessible chromatin and vitamin D receptor (VDR) binding.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	135-153
30018005-1	2018	The micronutrient vitamin D significantly modulates the human epigenome via enhancing genome-wide the rate of accessible chromatin and vitamin D receptor (VDR) binding.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	155-158
31344716-1	2019	OBJECTIVE:  To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM).	Vitamin D	49-58	vitamin D receptor	Homo sapiens	69-72
29402723-0	2018	Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNgamma levels and cathelicidin expression.	Vitamin D	73-82	interleukin 10	Homo sapiens	113-118
31053643-8	2019	These findings define a finely balanced homeostatic mechanism involving PTH and FGF23 together with protection from 1,25(OH)2D3 toxicity that is responsible for both adaptive vitamin D metabolism and mineral regulation.	Vitamin D	175-184	fibroblast growth factor 23	Mus musculus	80-85
29402723-8	2018	RESULTS: Serum levels of IL-10 and IFNgamma increased significantly in the group of patients with vitamin D supplementation, while IL-5, IL-9, and IL-13 decreased significantly.	Vitamin D	98-107	interleukin 10	Homo sapiens	25-30
29533153-3	2018	Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	0-18
28944524-0	2018	Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham-controlled trial.	Vitamin D	11-20	centromere protein J	Homo sapiens	60-64
30065237-2	2018	Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]).	Vitamin D	0-9	brain derived neurotrophic factor	Homo sapiens	34-46
29965969-5	2018	Both IL-15 and IL-10 induce MPhi differentiation, but IL-15 induces primary human monocytes to differentiate into antimicrobial MPhi (IL-15 MPhi) that robustly express the vitamin D pathway.	Vitamin D	172-181	interleukin 15	Homo sapiens	54-59
29965969-5	2018	Both IL-15 and IL-10 induce MPhi differentiation, but IL-15 induces primary human monocytes to differentiate into antimicrobial MPhi (IL-15 MPhi) that robustly express the vitamin D pathway.	Vitamin D	172-181	interleukin 15	Homo sapiens	54-59
29965969-6	2018	However, how vitamin D status alters IL-15 MPhi phenotype and function is unknown.	Vitamin D	13-22	interleukin 15	Homo sapiens	37-42
29965969-8	2018	The presence of physiological levels of 25D during differentiation of IL-15 MPhi led to a significant vitamin D-dependent antimicrobial response against intracellular Mycobacterium leprae but did not change the phenotype or phagocytic function of these MPhi.	Vitamin D	102-111	interleukin 15	Homo sapiens	70-75
29965969-9	2018	These data suggest that activation of the vitamin D pathway during IL-15 MPhi differentiation augments the antimicrobial response against M. leprae infection.	Vitamin D	42-51	interleukin 15	Homo sapiens	67-72
29574933-0	2018	The association of serum FGF23 and non-alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients.	Vitamin D	87-96	fibroblast growth factor 23	Homo sapiens	25-30
29574933-11	2018	In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver.	Vitamin D	39-48	fibroblast growth factor 23	Homo sapiens	144-149
29574933-11	2018	In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver.	Vitamin D	154-163	fibroblast growth factor 23	Homo sapiens	25-30
30066819-1	2018	OBJECTIVE: To verify the relationship between polymorphisms of the vitamin D receptor gene (VDR), clinical findings, and serum vitamin D (VD) levels in asthmatics.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	92-95
29875733-3	2018	The model describes, how VDR"s spatio-temporal binding profile provides key insight into the pleiotropic action of vitamin D.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	25-28
29951549-2	2018	1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR).	Vitamin D	44-53	vitamin D receptor	Homo sapiens	135-153
29951549-2	2018	1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR).	Vitamin D	44-53	vitamin D receptor	Homo sapiens	155-158
29951549-4	2018	In turn, VDR/RXR binds to DNA sequences termed vitamin D response elements in target genes, regulating gene transcription.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	9-12
29951549-4	2018	In turn, VDR/RXR binds to DNA sequences termed vitamin D response elements in target genes, regulating gene transcription.	Vitamin D	47-56	retinoid X receptor alpha	Homo sapiens	13-16
29686092-8	2018	We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers" milk.	Vitamin D	188-197	ectodysplasin A receptor	Homo sapiens	33-37
29686092-9	2018	This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.	Vitamin D	212-221	ectodysplasin A receptor	Homo sapiens	40-44
29686092-9	2018	This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.	Vitamin D	212-221	stearoyl-CoA desaturase	Homo sapiens	96-117
29686092-9	2018	This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.	Vitamin D	212-221	stearoyl-CoA desaturase	Homo sapiens	119-123
29486367-13	2018	CONCLUSIONS: After a 14-day lag, a single high dose of vitamin D led to greater production of 24,25(OH)2D3, presumably via induction of the 24-hydroxylase enzyme (CYP24A1), relative to the 25(OH)D3 value than did daily vitamin D supplementation, and this effect persisted for at least 28days after vitamin D administration.	Vitamin D	55-64	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	163-170
29176261-3	2018	But their exact relationship with clinical patients is still elusive, which inspired us to explore the potential association of vitamin D receptor (VDR) expression on circulating EPCs and serum vitamin D levels among patients with coronary artery disease (CAD).	Vitamin D	128-137	vitamin D receptor	Homo sapiens	148-151
30920112-1	2019	In mutant mice, reduced levels of Klotho promoted high levels of active vitamin D in the serum.	Vitamin D	72-81	klotho	Mus musculus	34-40
30920112-2	2019	Genetic or dietary manipulations that diminished active vitamin D alleviated aging-related phenotypes caused by Klotho down-regulation.	Vitamin D	56-65	klotho	Mus musculus	112-118
30920112-6	2019	These observations suggest that higher basal expression of an enzyme required for catabolizing vitamin D renders B6-kl/kl mice less susceptible to changes in Klotho expression, providing a plausible explanation for the lack of aging phenotypes on C57BL/6 strain.	Vitamin D	95-104	klotho	Mus musculus	158-164
30308088-4	2019	In the process we explore the mechanisms postulated to explain the action of these vitamin D analogues including action through the vitamin D receptor, action through other receptors e.g. FAM57B2 and dual action on transcriptional processes.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	132-150
30613854-1	2019	INTRODUCTION: X-linked hypophosphatemic rickets (XLH) can occasionally cause premature fusion of cranial sutures through an increased level of fibroblast growth factor 23 (FGF-23), which leads to the dysregulation of phosphate and vitamin D metabolism.	Vitamin D	231-240	fibroblast growth factor 23	Homo sapiens	143-170
30613854-1	2019	INTRODUCTION: X-linked hypophosphatemic rickets (XLH) can occasionally cause premature fusion of cranial sutures through an increased level of fibroblast growth factor 23 (FGF-23), which leads to the dysregulation of phosphate and vitamin D metabolism.	Vitamin D	231-240	fibroblast growth factor 23	Homo sapiens	172-178
32022412-0	2019	Are soluble ST2 levels influenced by vitamin D and/or the seasons?	Vitamin D	37-46	ST2	Homo sapiens	12-15
30731117-8	2019	It would be important to reconsider VDR as a pivotal molecule that mediates inter-organ communication to broaden the application of vitamin D signal modulators.	Vitamin D	132-141	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	36-39
30977086-0	2019	Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	27-30
30977086-5	2019	In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants.	Vitamin D	234-243	vitamin D receptor	Homo sapiens	35-38
29388391-8	2018	BAZ1A has been associated with neurodevelopmental impairment and dysregulation of several pathways including vitamin D metabolism.	Vitamin D	109-118	bromodomain adjacent to zinc finger domain 1A	Homo sapiens	0-5
31485552-4	2019	FGF23-mediated forms of hypophosphatemia are characterized by phosphaturia and low or low-normal calcitriol concentrations, and unlike nutritional rickets, these cannot be cured with nutritional vitamin D supplementation.	Vitamin D	195-204	fibroblast growth factor 23	Homo sapiens	0-5
31485552-7	2019	Historically phosphate supplementation and therapy using analogs of highly active vitamin D (eg, calcitriol, alfacalcidol, paricalcitol, eldecalcitol) have been used to manage conditions involving hypophosphatemia; however, recently a neutralizing antibody for FGF23 (burosumab) has emerged as a promising treatment agent for FGF23-mediated disorders.	Vitamin D	82-91	fibroblast growth factor 23	Homo sapiens	261-266
29657326-3	2018	Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	154-172
31485552-7	2019	Historically phosphate supplementation and therapy using analogs of highly active vitamin D (eg, calcitriol, alfacalcidol, paricalcitol, eldecalcitol) have been used to manage conditions involving hypophosphatemia; however, recently a neutralizing antibody for FGF23 (burosumab) has emerged as a promising treatment agent for FGF23-mediated disorders.	Vitamin D	82-91	fibroblast growth factor 23	Homo sapiens	326-331
29657326-3	2018	Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	174-177
31205465-0	2019	Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-gamma Functional Module of Autophagy in Rheumatoid Arthritis.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	65-68
29388046-3	2018	METHOD: We identified all studies that assessed the changes of TPO-Ab and Tg-Ab in patients with AIT under the treatment of vitamin D from PubMed, Embase, The Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and VIP Database.	Vitamin D	124-133	thyroid peroxidase	Homo sapiens	63-66
30833469-8	2019	Moreover, fasting upregulated the vitamin D catabolizing CYP24A1 in the kidney through the PGC-1alpha-ERRalpha pathway.	Vitamin D	34-43	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	57-64
29388046-5	2018	The results showed that Vitamin D supplementation significantly dropped TPO-Ab titers [three studies, random effects standardized mean difference (SMD): -1.11, 95% CI -1.52 to -0.70, P &lt; 0.01] at six months, but not at no more than 3 months [random effects SMD: -0.12, 95% CI: -0.69 to 0.44, P = 0.67].	Vitamin D	24-33	thyroid peroxidase	Homo sapiens	72-75
31071734-0	2019	Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto"s Thyroiditis?	Vitamin D	25-34	thyroid peroxidase	Homo sapiens	71-74
29388046-8	2018	CONCLUSIONS: The current evidence suggests that vitamin D supplementation could decrease serum TPO-Ab and Tg-Ab titers of patients with AIT in the short-term (about six months).	Vitamin D	48-57	thyroid peroxidase	Homo sapiens	95-98
31193232-4	2019	We therefore queried whether FoxO3a participates in vitamin D-mediated regulation of calcium transport pathways or matrix calcification, independent of reactive oxygen species (ROS) formation.	Vitamin D	52-61	forkhead box O3	Mus musculus	29-35
28004271-0	2018	Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring.	Vitamin D	9-18	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	162-180
28004271-0	2018	Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring.	Vitamin D	9-18	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	182-185
28008453-0	2018	Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	15-19
31058117-1	2019	Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease.	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	0-27
28008453-10	2018	CONCLUSIONS: The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination (GC1F/1F), and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS.	Vitamin D	157-166	GC vitamin D binding protein	Homo sapiens	59-63
31058117-1	2019	Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease.	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	29-35
29456680-11	2018	The results showed that children with bronchial asthma are often accompanied by different degrees of changes in VDR gene polymorphism, which is negatively correlated with the severity of asthma, so vitamin D should be strengthened to ameliorate the prognosis of children.	Vitamin D	198-207	vitamin D receptor	Homo sapiens	112-115
30718230-5	2019	Interfering VDR signals, such as low vitamin D diet and VDR deficiency in donor cells as well as macrophage depletion prevented myelofibrosis in this model.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	12-15
31089432-1	2019	Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia.	Vitamin D	79-88	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	44-51
31089432-1	2019	Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia.	Vitamin D	107-116	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	44-51
31089432-8	2019	The panel of vitamin D metabolites evaluated by liquid chromatography showed the typical profile of CYP24A1 mutations, namely, low 24,25(OH)2D3, elevated 25(OH)D3:24,25(OH)2D3 ratio, and undetectable 1,24,25(OH)3D3.	Vitamin D	13-22	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	100-107
31089432-11	2019	Conclusion: CYP24A1 gene mutations should be considered in cases of PTH-independent hypercalcemia, once that more common causes (hypercalcemia of malignancy, granulomatous diseases, and vitamin D intoxication) have been ruled out.	Vitamin D	186-195	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	12-19
30668811-0	2019	Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	41-48
30969078-2	2019	In our study we aimed to investigate the correlations among urothelial type bladder cancer polymorphisms, ApaI, BsmI, FokI, and TaqI, prevalently observed in the vitamin D receptor (VDR) gene and plasma vitamin D levels in a Turkish population.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	182-185
31084433-6	2019	Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues.	Vitamin D	40-49	interleukin 22	Homo sapiens	108-113
31084433-6	2019	Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues.	Vitamin D	40-49	interleukin 17A	Homo sapiens	144-149
30830277-2	2019	It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	83-86
30830277-10	2019	CONCLUSION: Based on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	105-108
28870465-0	2018	Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue.	Vitamin D	71-80	interleukin 17A	Mus musculus	14-19
28870465-2	2018	OBJECTIVE: We sought to clarify whether and how the topical vitamin D analogue calcipotriol (CAL) controls the IL-17A-mediated pathogenesis of murine psoriasis-like dermatitis in vivo.	Vitamin D	60-69	interleukin 17A	Mus musculus	111-117
29290431-6	2018	Immune activation of the intracrine vitamin D pathway, including induction of inducible nitric oxide synthase and beta-defensin gene expression by 1,25(OH)2D3, has been documented in the mammary glands of lactating dairy cows.	Vitamin D	36-45	nitric oxide synthase 2	Bos taurus	78-109
29433089-2	2018	These physiological actions caused by vitamin D are triggered by the specific binding of vitamin D to its receptor (VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	116-119
29433089-2	2018	These physiological actions caused by vitamin D are triggered by the specific binding of vitamin D to its receptor (VDR).	Vitamin D	89-98	vitamin D receptor	Homo sapiens	116-119
29433089-3	2018	Here we investigated the specific interactions and binding affinities between VDR and vitamin D derivatives, using ab initio fragment molecular orbital (FMO) calculations.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	78-81
28710021-4	2018	Here we review our recent findings in this area, including our data revealing that reduction of the expression of the vitamin D receptor (Vdr) within BCa cells accelerates primary tumor growth and enables the development of metastases, demonstrating a tumor autonomous effect of vitamin D signaling to suppress BCa metastases.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	138-141
28734987-3	2018	Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues.	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	0-25
28734987-3	2018	Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues.	Vitamin D	122-131	GC vitamin D binding protein	Homo sapiens	0-25
29506625-0	2018	VDBP, VDR Mutations and Other Factors Related With Vitamin D Metabolism May Be Associated With Type 1 Diabetes Mellitus.	Vitamin D	51-60	GC vitamin D binding protein	Homo sapiens	0-4
29506625-0	2018	VDBP, VDR Mutations and Other Factors Related With Vitamin D Metabolism May Be Associated With Type 1 Diabetes Mellitus.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	6-9
29506625-3	2018	Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism.	Vitamin D	83-92	GC vitamin D binding protein	Homo sapiens	110-114
29506625-3	2018	Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	120-138
29506625-3	2018	Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	140-143
29506625-10	2018	When the relation between the risk factors and mutations were investigated, it was found that VDBP, free vitamin D and bioactive vitamin D were significantly associated with rs7041 mutation in VDBP whereas HDL was significantly associated with rs2228570 mutation in VDR.	Vitamin D	105-114	GC vitamin D binding protein	Homo sapiens	193-197
29506625-10	2018	When the relation between the risk factors and mutations were investigated, it was found that VDBP, free vitamin D and bioactive vitamin D were significantly associated with rs7041 mutation in VDBP whereas HDL was significantly associated with rs2228570 mutation in VDR.	Vitamin D	129-138	GC vitamin D binding protein	Homo sapiens	193-197
29506625-10	2018	When the relation between the risk factors and mutations were investigated, it was found that VDBP, free vitamin D and bioactive vitamin D were significantly associated with rs7041 mutation in VDBP whereas HDL was significantly associated with rs2228570 mutation in VDR.	Vitamin D	129-138	vitamin D receptor	Homo sapiens	266-269
29483716-3	2018	CYP24A1 is the gene encoding vitamin D 24 hydroxylase and is a vitamin D responsive gene.	Vitamin D	29-38	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
29415666-2	2018	Therefore, the aim of this study was to examine the influence of vitamin D receptor (VDR) polymorphisms on secondary hyperparathyroidism and its association with vitamin D levels in black and white South African study participants.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	85-88
29467625-8	2018	Notably N-cadherin, implicated in activity for dendritic outgrowth, is upregulated by vitamin D.	Vitamin D	86-95	cadherin 2	Mus musculus	8-18
29128634-3	2018	Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	98-116
29128634-3	2018	Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	118-121
29243851-3	2018	Appraisal of the liver revealed an up-regulation of mRNA expressions of the small heterodimer partner (Shp) and attenuation of Cyp7a1, which contributed to hypercholesterolemia in vitamin D-deficiency.	Vitamin D	180-189	nuclear receptor subfamily 0, group B, member 2	Mus musculus	103-106
29230954-4	2018	Vitamin D exerts its effect through vitamin D receptors (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	57-60
31038028-11	2018	Current evidence suggests that vitamin D supplementation in conjunction with standard of care (e.g. chemotherapy, radiation therapy) may confer clinical benefits such as a decrease in serum PSA levels and VDR expression but further research is required to ascertain these results.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	205-208
29416220-2	2018	Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	58-76
29416220-2	2018	Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	78-81
29416220-3	2018	Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	46-49
29342138-2	2018	This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and vitamin D homeostasis.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	32-37
29342166-12	2018	Consistently, a significantly decreased activation of the SCAP/SREBP lipogenic pathway and lower levels of CML protein adducts and RAGE expression were observed in skeletal muscle of animals treated with vitamin D.	Vitamin D	204-213	SREBF chaperone	Mus musculus	58-62
29342166-13	2018	Collectively, these data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-kappaB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements.	Vitamin D	39-48	SREBF chaperone	Mus musculus	122-126
29342166-13	2018	Collectively, these data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-kappaB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements.	Vitamin D	238-247	SREBF chaperone	Mus musculus	122-126
29032145-1	2018	Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	109-112
31259360-1	2019	Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	90-108
31259360-1	2019	Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	110-113
30639520-0	2019	Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: Implications for the cytokine response.	Vitamin D	0-9	microRNA 155	Homo sapiens	34-41
29658431-2	2019	The circulating biologically active form of vitamin D is regulated by the catabolic mechanism of cytochrome P450 24-hydroxylase (CYP24A1) enzyme.	Vitamin D	44-53	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	129-136
29658431-3	2019	The over-expression of CYP24A1 negatively regulates the vitamin D level, which is the causative agent of chronic kidney disease, osteoporosis and several types of cancers.	Vitamin D	56-65	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	23-30
30553931-1	2019	Calcitroic acid, the excretory form of vitamin D, is the terminal product of a 5-step pathway catalyzed by CYP24A1, commencing with C24-hydroxylation of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3).	Vitamin D	39-48	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	107-114
30659895-8	2019	RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels.	Vitamin D	9-13	collagen type I alpha 1 chain	Homo sapiens	139-145
30659895-8	2019	RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels.	Vitamin D	9-13	vitamin D receptor	Homo sapiens	364-382
30659895-8	2019	RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels.	Vitamin D	9-13	vitamin D receptor	Homo sapiens	384-387
29621752-1	2018	BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	12-39
29621752-1	2018	BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	41-47
29301185-9	2017	Multivariate regression analysis revealed that daylight outdoor hours (beta=2.948, P=0.003) and vitamin D intake (beta=2.865, P=0.003) affected the 25(OH)D level; the presence of type 1 diabetes or urinary VDBP excretion was not significant.	Vitamin D	96-105	GC vitamin D binding protein	Homo sapiens	206-210
29080642-2	2017	For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)2D and 0.03% for 25(OH)D) is free, with more than 99% bound to the vitamin D binding protein (DBP) and albumin (approximately 85% and 15%, respectively).	Vitamin D	8-17	GC vitamin D binding protein	Homo sapiens	128-153
29220424-3	2017	Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810].	Vitamin D	28-37	GC vitamin D binding protein	Homo sapiens	166-191
29220424-3	2017	Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810].	Vitamin D	28-37	GC vitamin D binding protein	Homo sapiens	193-196
29220424-3	2017	Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810].	Vitamin D	28-37	vitamin D receptor	Homo sapiens	271-289
28803336-10	2017	This study is the first to achieve lung-specific overexpression of VDR in TG mice: an interesting animal model useful for studying the relation between airway cell inflammation and vitamin D signaling.	Vitamin D	181-190	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	67-70
28589382-3	2017	We analyzed gene and protein expression of VDR and PR and gene expression of vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzymes in follicular cancer cells and the adjacent non-neoplastic thyroid tissue (NNTT).	Vitamin D	77-86	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	115-122
29176823-9	2017	This suggested complex might also include VDR, which greatly contributes to Ca+2 hemostasis with its ligand vitamin D.	Vitamin D	108-117	vitamin D receptor	Homo sapiens	42-45
29177013-7	2017	Serum BDNF level was significantly higher in Vit D deficient group (p = 0.001), and was decreased in the OVX + HD.	Vitamin D	45-50	brain-derived neurotrophic factor	Rattus norvegicus	6-10
29209434-6	2017	The studies presented in this review suggest that whether vitamin D may have beneficial effects in disease course or not, may be dependent on factors such as ethnicity, gender, diet, vitamin D receptor (VDR) polymorphisms and sunlight exposure.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	183-201
29209434-6	2017	The studies presented in this review suggest that whether vitamin D may have beneficial effects in disease course or not, may be dependent on factors such as ethnicity, gender, diet, vitamin D receptor (VDR) polymorphisms and sunlight exposure.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	203-206
29160418-12	2017	Vitamin D levels correlated negatively with body weight, lung resistance levels at 25 mg/mL of methacholine, total inflammatory cells, and IL-1beta and IL-17 concentrations in BALF.	Vitamin D	0-9	interleukin 17A	Mus musculus	152-157
29127362-0	2017	Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	23-26
29127362-1	2017	The functional study of different mutations on vitamin D receptor (VDR) gene causing hereditary vitamin D-resistant rickets (HVDRR) remains limited.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	67-70
28703134-1	2017	Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	164-182
28945992-0	2017	Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control.	Vitamin D	60-69	leukocyte immunoglobulin like receptor B1	Homo sapiens	22-27
28945992-0	2017	Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control.	Vitamin D	60-69	microRNA 152	Homo sapiens	29-36
28945992-5	2017	Circulating levels of miR-7 (sixfold reduction, P=.01), miR-152 (1.5-fold increase, P=.03), and miR-192 (1.7-fold reduction, P=.026) displayed significant treatment-by-time interactions between the placebo- and the vitamin-D-treated groups.	Vitamin D	215-224	leukocyte immunoglobulin like receptor B1	Homo sapiens	22-27
28945992-6	2017	Plasma levels of miR-7 were reduced in the vitamin D and increased in the placebo group.	Vitamin D	43-52	leukocyte immunoglobulin like receptor B1	Homo sapiens	17-22
29088291-3	2017	Vitamin D is transported by vitamin D-binding protein (group-specific component, GC) through the bloodstream and regulates cellular actions by binding to vitamin D receptor (VDR).	Vitamin D	0-9	GC vitamin D binding protein	Sus scrofa	28-53
29046816-2	2017	A better understanding of vitamin D metabolism, particularly vitamin D binding protein, is important when elucidating this relationship.	Vitamin D	26-35	GC vitamin D binding protein	Homo sapiens	61-86
28836398-11	2017	Although the individuals taking part in this study had normal levels of vitamin D, the increase in VDR expression levels may perhaps be a response to a defect in vitamin D processing.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	99-102
28836398-13	2017	Of course, further studies are required to identify the mechanism of action of vitamin D by analyzing genes involved in its signaling pathway, particularly VDR and CYP24A1.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	156-159
28836398-13	2017	Of course, further studies are required to identify the mechanism of action of vitamin D by analyzing genes involved in its signaling pathway, particularly VDR and CYP24A1.	Vitamin D	79-88	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	164-171
30941131-0	2019	The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	108-111
28786835-6	2017	The function of the RAGE receptor is inter-twined with Toll-like receptor (TLR) signalling and vitamin D levels.	Vitamin D	95-104	advanced glycosylation end-product specific receptor	Homo sapiens	20-24
31011579-2	2019	Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	104-122
28130182-8	2017	Treatment of BEC with 10muM cholecalciferol led to increases in both CYP24A1 and CFTR mRNA levels, even when added to the apical surface of cells grown in an air-liquid interface, suggesting that topical administration of vitamin D could be used therapeutically.	Vitamin D	222-231	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	69-76
31011579-2	2019	Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	134-137
31011579-13	2019	In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	96-99
31011579-13	2019	In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	96-99
28130182-8	2017	Treatment of BEC with 10muM cholecalciferol led to increases in both CYP24A1 and CFTR mRNA levels, even when added to the apical surface of cells grown in an air-liquid interface, suggesting that topical administration of vitamin D could be used therapeutically.	Vitamin D	222-231	cystic fibrosis transmembrane conductance regulator	Mus musculus	81-85
28330721-1	2017	Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	93-111
28330721-1	2017	Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	113-116
28552837-7	2017	In the mild CTS patients, vitamin D levels were significantly lower than those electrophysiologically normal patients (P=0.003).	Vitamin D	26-35	transthyretin	Homo sapiens	12-15
30890957-3	2019	Moreover, the nearly ubiquitous expression of VDR enabled vitamin D to acquire additional physiological functions, such as the support of the innate immune system in its defense against microbes.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	46-49
30832722-3	2019	This study was designed to examine the effects on vitamin D supplementation on serum levels of vitamin D receptor (VDR), fibrogenic factors, and fibrogenic microRNAs (MiR) in NAFLD patients.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	95-113
28552837-9	2017	There was no significant relationship between the pain and vitamin D levels in the normal group, while vitamin D level was significantly lower in the mild CTS group (P=0.730 and P=0.002; respectively).	Vitamin D	103-112	transthyretin	Homo sapiens	155-158
30832722-3	2019	This study was designed to examine the effects on vitamin D supplementation on serum levels of vitamin D receptor (VDR), fibrogenic factors, and fibrogenic microRNAs (MiR) in NAFLD patients.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	115-118
30832722-9	2019	DISCUSSION: This is the first randomized controlled trial that will determine the effect of vitamin D supplementation on serum levels of VDR, fibrogenic factors, and fibrogenic MiRs in NAFLD patients.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	137-140
28552837-10	2017	DISCUSSION: Vitamin D deficiency increases the pain intensity in patients with CTS.	Vitamin D	12-21	transthyretin	Homo sapiens	79-82
30399417-11	2019	Overall, vitamin D deficient mice resolved NTHi infection faster with a faster resolution of local lung inflammation, possibly through upregulation of CRAMP.	Vitamin D	9-18	cathelicidin antimicrobial peptide	Mus musculus	151-156
28552837-12	2017	Further studies involving analyses of post-vitamin D replacement therapy are warranted to confirm the association between vitamin D deficiency and pain due to CTS.	Vitamin D	122-131	transthyretin	Homo sapiens	159-162
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	255-273
29022486-7	2017	However, further studies focusing on the vitamin D receptor variants and haplotypes effects on vitamin D and vitamin D receptor concentrations, activities, and functionalities are needed.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	109-127
30465855-2	2019	Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	275-278
30476590-0	2019	Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells.	Vitamin D	0-9	intercellular adhesion molecule 1	Homo sapiens	54-87
30476590-0	2019	Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells.	Vitamin D	0-9	intercellular adhesion molecule 1	Homo sapiens	89-95
30796319-1	2019	Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D.	Vitamin D	118-127	7-dehydrocholesterol reductase	Homo sapiens	38-68
28843271-11	2017	Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	108-126
30796319-1	2019	Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D.	Vitamin D	118-127	7-dehydrocholesterol reductase	Homo sapiens	70-75
30796319-2	2019	Our aim was to evaluate the impact of vitamin D-related polymorphisms and DHCR7 levels in the association between vitamin D deficiency and altered lipid profile in rheumatoid arthritis (RA).	Vitamin D	114-123	7-dehydrocholesterol reductase	Homo sapiens	74-79
30258921-0	2017	Association of vitamin D receptor gene polymorphism (VDR) with vitamin D deficiency, metabolic and inflammatory markers in Egyptian obese women.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	53-56
28825325-0	2019	Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats.	Vitamin D	0-9	nitric oxide synthase 3	Rattus norvegicus	65-69
30321476-0	2019	Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial.	Vitamin D	12-21	retinoid X receptor alpha	Homo sapiens	65-69
30321476-1	2019	We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass.	Vitamin D	77-86	retinoid X receptor alpha	Homo sapiens	131-156
30321476-1	2019	We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass.	Vitamin D	77-86	retinoid X receptor alpha	Homo sapiens	158-162
30321476-2	2019	In this study, we used an existing randomized trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation.	Vitamin D	101-110	retinoid X receptor alpha	Homo sapiens	159-163
28751957-11	2017	As expected, subjects with e-GFR &lt; 60 had significantly lower 1,25 (OH) vitamin D levels and significantly elevated PTH-intact.	Vitamin D	75-84	Rap guanine nucleotide exchange factor 5	Homo sapiens	29-32
30594355-8	2019	Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status.	Vitamin D	54-63	GC vitamin D binding protein	Bos taurus	98-123
30594355-8	2019	Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status.	Vitamin D	54-63	interferon gamma	Bos taurus	135-139
30205156-3	2019	The major circulating form of vitamin D is 25(OH)D and both D2 and D3 forms are routinely measured by LC/MS/MS to assess vitamin D status, due to their relatively long half-lives and much higher concentrations compared to 1alpha,25(OH)2D.	Vitamin D	121-130	immunoglobulin heavy diversity 2-15	Homo sapiens	60-69
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	84-93	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	125-132
30205156-11	2019	With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease.	Vitamin D	225-234	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	125-132
28576565-0	2017	The expression of VDR mRNA but not NF-kappaB surprisingly decreased after vitamin D treatment in multiple sclerosis patients.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	18-21
28576565-1	2017	BACKGROUND AND PURPOSE: The aim of this study was to investigate the expression levels of vitamin D receptor (VDR) and NF-kappaB mRNAs in vitamin D (VD) supplemented multiple sclerosis (MS) patients.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	110-113
30696596-1	2019	Unraveling the vitamin D - RANKL association.	Vitamin D	15-24	TNF superfamily member 11	Homo sapiens	27-32
28706201-5	2017	DHCR7 encodes an enzyme important in cutaneous synthesis of vitamin D and DHCR7 mutations are believed to be important for early humans to adapt to Northern Europe where residents have reduced ultraviolet-B exposure and tend to have light skin color.	Vitamin D	60-69	7-dehydrocholesterol reductase	Homo sapiens	0-5
30696596-3	2019	The discovery of receptor activator of nuclear factor kB (RANK) and RANK binding ligand (RANKL) uncovered the bone homeostasis and molecular mechanism by which multiple compounds (including vitamin D) regulated osteoclast differentiation; a function mediated by osteoblastic cells and osteoclast-precursor cells.	Vitamin D	190-199	TNF superfamily member 11	Homo sapiens	68-87
30696596-3	2019	The discovery of receptor activator of nuclear factor kB (RANK) and RANK binding ligand (RANKL) uncovered the bone homeostasis and molecular mechanism by which multiple compounds (including vitamin D) regulated osteoclast differentiation; a function mediated by osteoblastic cells and osteoclast-precursor cells.	Vitamin D	190-199	TNF superfamily member 11	Homo sapiens	89-94
30696596-4	2019	HYPOTHESIS: In a country burdened by vitamin D deficiency, causal relation between hypovitaminosis D and GCTB was hypothesized based on the vitamin D mediated RANKL expression and osteoclastogenesis, as India is also a population with higher incidence of GCTB as compared to Western populations described in the literature.	Vitamin D	140-149	TNF superfamily member 11	Homo sapiens	159-164
30696596-5	2019	The possibility of vitamin D regulated osteoclastogenesis in GCTB is postulated on the evidence from molecular research linking it to the RANK/RANKL/OPG pathway.	Vitamin D	19-28	TNF superfamily member 11	Homo sapiens	143-148
30696596-5	2019	The possibility of vitamin D regulated osteoclastogenesis in GCTB is postulated on the evidence from molecular research linking it to the RANK/RANKL/OPG pathway.	Vitamin D	19-28	basic transcription factor 3 pseudogene 11	Homo sapiens	149-152
30696596-11	2019	DISCUSSION: The differential expression of RANKL and OPG in response to levels of vitamin D has been established.	Vitamin D	82-91	TNF superfamily member 11	Homo sapiens	43-48
30696596-11	2019	DISCUSSION: The differential expression of RANKL and OPG in response to levels of vitamin D has been established.	Vitamin D	82-91	basic transcription factor 3 pseudogene 11	Homo sapiens	53-56
31149190-2	2017	Vitamin D action is mediated through vitamin D receptor (VDR), which acts as a transcription factor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	37-55
30678432-2	2019	Vitamin D has been hypothesized to lower the risk of breast cancer via the nuclearvitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	102-105
30809535-0	2019	Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys.	Vitamin D	0-9	aquaporin 4	Mus musculus	49-54
30809535-8	2019	In addition, AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue.	Vitamin D	153-162	aquaporin 4	Mus musculus	54-59
31149190-2	2017	Vitamin D action is mediated through vitamin D receptor (VDR), which acts as a transcription factor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	57-60
31149190-14	2017	Conclusion: The results provide new insights of Cdx-2 polymorphism is involved in vitamin D deficiency, highlighting the important role of epigenetic modification of vitamin D receptor and male infertility along with the genetic context.	Vitamin D	82-91	caudal type homeobox 2	Homo sapiens	48-53
30285234-5	2019	The IL10/IL12 ratio in tolerogenic DCs increased with vitamin D.	Vitamin D	54-63	interleukin 10	Homo sapiens	4-8
31149190-14	2017	Conclusion: The results provide new insights of Cdx-2 polymorphism is involved in vitamin D deficiency, highlighting the important role of epigenetic modification of vitamin D receptor and male infertility along with the genetic context.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	166-184
28899076-0	2017	Letter to the Editor: The Effect of Genetic Factors on the Response to Vitamin D Supplementation May Be Mediated by Vitamin D-Binding Protein Concentrations.	Vitamin D	71-80	GC vitamin D binding protein	Homo sapiens	116-141
30963970-10	2019	CONCLUSION: The presence of the TT allele of the SNP rs2228570 of the VDR gene and the SNP rs731236 of the CC genotype was associated with the presence of osteopenia and decreased bone mineral density alongside malfunctions of vitamin D.	Vitamin D	227-236	vitamin D receptor	Homo sapiens	70-73
28242261-2	2017	These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	98-116
31298160-5	2019	Via activating the VDR, vitamin D has direct effects on the epigenome and the expression of more than 1000 genes in most human tissues and cell types.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	19-22
31298160-6	2019	CONCLUSIONS: The pleiotropic action of vitamin D in health and disease prevention is explained through complex gene regulatory events of the transcription factor VDR.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	162-165
31333100-3	2019	Recent research has been focusing on the role of vitamin D in the pathogenesis of endometriosis, basing on the evidence of the presence of vitamin D receptor and the enzymes required for vitamin D synthesis in the ectopic endometrium.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	139-157
31333100-7	2019	RESULTS: The relationship between endometriosis and Vitamin D has been analyzed through the evaluation of vitamin D serum level, the polymorphism of vitamin D receptor and the role of vitamin D-binding protein in patient with endometriosis.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	149-167
31566129-1	2019	To the best of our knowledge, this is the first study to compare circulating IL-25 and IL-33 levels with vitamin D synthesis in the literature.	Vitamin D	105-114	interleukin 25	Homo sapiens	77-82
28242261-2	2017	These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	118-121
30584976-10	2019	RESULTS: BDNF level increased while c-fos, Bax and caspase-3 levels decreased (p &lt; 0.0001, in all) in the hippocampal neurons of the groups that were pre-treated with vitamin D before the administration of PTZ and KA, in comparison with the PTZ and KA groups.	Vitamin D	170-179	brain-derived neurotrophic factor	Rattus norvegicus	9-13
28242261-2	2017	These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	118-121
30584976-10	2019	RESULTS: BDNF level increased while c-fos, Bax and caspase-3 levels decreased (p &lt; 0.0001, in all) in the hippocampal neurons of the groups that were pre-treated with vitamin D before the administration of PTZ and KA, in comparison with the PTZ and KA groups.	Vitamin D	170-179	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-41
28242261-3	2017	In the present study, we investigated the interactions between VDR and vitamin D derivatives using ab initio molecular simulation, in order to elucidate the reason for the significant difference in their effects on VDR activity.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	63-66
30456544-10	2019	CONCLUSION: Vitamin D deficiency was common in kidney transplant recipients in North India, associated with low FGF23 and high E-selectin.	Vitamin D	12-21	fibroblast growth factor 23	Homo sapiens	112-117
28242261-3	2017	In the present study, we investigated the interactions between VDR and vitamin D derivatives using ab initio molecular simulation, in order to elucidate the reason for the significant difference in their effects on VDR activity.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	215-218
30137362-3	2019	Furthermore, vitamin D receptor (VDR) and vitamin D-metabolizing enzymes [cytochrome 450 (CYP)] expression in adipose tissue (AT) might affect AT insulin sensitivity.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	33-36
28242261-5	2017	This finding will be helpful for proposing new vitamin D derivatives as a potent modulator or inhibitor against VDR.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	112-115
28388568-2	2017	Moreover, plasma vitamin D was also found significantly associated with the concentration of vitamin D binding protein (VDBP).	Vitamin D	17-26	GC vitamin D binding protein	Homo sapiens	93-118
29981368-2	2019	Many mechanistic studies show that the active vitamin D metabolite (1alpha,25-dihydroxyvitamin D3 or calcitriol) inhibits proliferation and promotes epithelial differentiation of human colon carcinoma cell lines that express vitamin D receptor (VDR) via the regulation of a high number of genes.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	225-243
29981368-2	2019	Many mechanistic studies show that the active vitamin D metabolite (1alpha,25-dihydroxyvitamin D3 or calcitriol) inhibits proliferation and promotes epithelial differentiation of human colon carcinoma cell lines that express vitamin D receptor (VDR) via the regulation of a high number of genes.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	245-248
28388568-2	2017	Moreover, plasma vitamin D was also found significantly associated with the concentration of vitamin D binding protein (VDBP).	Vitamin D	17-26	GC vitamin D binding protein	Homo sapiens	120-124
28695056-5	2017	mTOR mRNA levels were higher (P=0.036) and LC3 mRNA levels were lower (P&lt;0.001) in severe vitamin D deficiency group compared to vitamin D insufficiency group.	Vitamin D	93-102	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	43-46
28695056-6	2017	The counts of CD4+ T cells and the CD4/CD8 ratio were significantly higher in severe vitamin D deficiency group compared to vitamin D insufficiency group (P=0.001, P&lt;0.001,respectively).	Vitamin D	85-94	CD8a molecule	Homo sapiens	39-42
30671219-3	2019	Vitamin D receptors (VDR) genetic variants may be related to vitamin D status and BMD.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	0-19
28617856-0	2017	The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	25-28
30671219-3	2019	Vitamin D receptors (VDR) genetic variants may be related to vitamin D status and BMD.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	21-24
30671219-4	2019	Objectives: To evaluate the effect of VDR genetic variants on vitamin D levels and BMD in betaTM Egyptian patients supplemented with vitamin D.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	38-41
30671219-4	2019	Objectives: To evaluate the effect of VDR genetic variants on vitamin D levels and BMD in betaTM Egyptian patients supplemented with vitamin D.	Vitamin D	133-142	vitamin D receptor	Homo sapiens	38-41
30959383-1	2019	OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.	Vitamin D	122-131	GC vitamin D binding protein	Homo sapiens	68-93
28617856-2	2017	The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance.	Vitamin D	134-143	vitamin D receptor	Homo sapiens	89-92
28721141-2	2017	This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other.	Vitamin D	93-102	GC vitamin D binding protein	Homo sapiens	170-195
30099788-7	2019	In univariable analyses, vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant incidence rate ratio (IRR 1.52, 95% CI 1.08-2.15, P = 0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P = 0.034).	Vitamin D	25-34	insulin receptor related receptor	Homo sapiens	148-151
30099788-7	2019	In univariable analyses, vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant incidence rate ratio (IRR 1.52, 95% CI 1.08-2.15, P = 0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P = 0.034).	Vitamin D	25-34	insulin receptor related receptor	Homo sapiens	267-270
30729229-2	2019	Loss-of-function mutations in CYP24A1 result in impaired dehydroxylation of active vitamin D (calcitriol).	Vitamin D	83-92	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
28721141-2	2017	This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other.	Vitamin D	93-102	GC vitamin D binding protein	Homo sapiens	197-201
30314996-0	2018	Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/beta-catenin signaling.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	18-36
28177670-12	2017	In conclusion, vitamin D can be demonstrated as a promising cardioprotective agent in MI and PPAR-gamma significantly contributes toward vitamin-D-mediated protection.	Vitamin D	137-146	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	93-103
30314996-9	2018	Vitamin D enhanced VDR expression and induced DNA damage.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	19-22
30314996-16	2018	Vitamin D-induced VDR expression increased the sensitivity of MCF-7 stem cells to tamoxifen by inhibiting Wnt/beta-catenin signaling.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	18-21
28335003-3	2017	We investigated whether variation in binding of a transcription factor, the vitamin D receptor (VDR), whose activating ligand vitamin D has been proposed as a modifiable factor in multiple disorders, could explain any of these associations.	Vitamin D	76-85	vitamin D receptor	Homo sapiens	96-99
29153269-3	2018	Plasma 25(OH)D levels and genetic variants in vitamin D pathway (NADSYN1/DHCR7, GC, CYP3A4, CYP2R1, CYP27A1, CYP27B1, VDR, CYP24A1, and LRP2) were measured using the blood sample collected at the first trimester.	Vitamin D	46-55	NAD synthetase 1	Homo sapiens	65-72
29153269-8	2018	Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements.	Vitamin D	113-122	NAD synthetase 1	Homo sapiens	12-19
29153269-8	2018	Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements.	Vitamin D	113-122	7-dehydrocholesterol reductase	Homo sapiens	20-25
29153269-14	2018	CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China.	Vitamin D	32-41	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	63-70
29153269-14	2018	CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China.	Vitamin D	32-41	NAD synthetase 1	Homo sapiens	76-83
29153269-14	2018	CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China.	Vitamin D	32-41	7-dehydrocholesterol reductase	Homo sapiens	84-89
28335003-11	2017	Replicated VDR-BVs associated with these disorders could represent causal disease risk alleles whose effect may be modifiable by vitamin D levels.	Vitamin D	129-138	vitamin D receptor	Homo sapiens	11-14
28177161-0	2017	VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D Treatment-Induced Increase in Bone Mass by Suppressing Bone Resorption.	Vitamin D	51-60	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
29481636-7	2018	Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	44-49
29481636-8	2018	Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients.	Vitamin D	44-53	klotho	Homo sapiens	6-12
29481636-10	2018	In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m2.	Vitamin D	44-53	klotho	Homo sapiens	85-91
28615947-4	2017	Another important player in regulating mineral metabolism is vitamin D receptor (VDR), which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	81-84
29481636-10	2018	In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m2.	Vitamin D	44-53	thrombopoietin	Mus musculus	106-108
29481636-11	2018	Conclusions: Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.	Vitamin D	13-22	klotho	Homo sapiens	50-56
29481636-11	2018	Conclusions: Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.	Vitamin D	13-22	fibroblast growth factor 23	Homo sapiens	132-137
28615947-5	2017	Serum phosphate levels influence fibroblast growth factor 23 (FGF-23) production, a phosphatonin that modulates serum phosphate reabsorption, PTH synthesis, and vitamin D production.	Vitamin D	161-170	fibroblast growth factor 23	Homo sapiens	33-60
28615947-5	2017	Serum phosphate levels influence fibroblast growth factor 23 (FGF-23) production, a phosphatonin that modulates serum phosphate reabsorption, PTH synthesis, and vitamin D production.	Vitamin D	161-170	fibroblast growth factor 23	Homo sapiens	62-68
28615947-6	2017	Current therapeutic approaches consist of 1) phosphate intake control by diet or phosphate binders, 2) vitamin D by VDR activation, and 3) calcimimetic agents that activate CaSR.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	116-119
29088772-1	2017	Vitamin D is an important modulator of cellular proliferation through the vitamin D receptor (VDR) that binds to DNA in the regulatory sequences of target genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	74-92
30555810-2	2018	Homozygous or heterozygous mutations in the vitamin D receptor (VDR) gene leading to complete or partial target organ resistance to the action of 1alpha, 25-dihydroxyvitamin D3 (the active form of vitamin D) are responsible for HVDRR.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	64-67
29088772-1	2017	Vitamin D is an important modulator of cellular proliferation through the vitamin D receptor (VDR) that binds to DNA in the regulatory sequences of target genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	94-97
28385183-3	2017	Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez in Mexico City.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	81-84
30455079-17	2018	Overall, our results suggest that activating the vitamin D pathway could be a mechanism to decrease STAT1 and 3 activation and inflammatory cytokine output in NK-LGLL patients.	Vitamin D	49-58	signal transducer and activator of transcription 1	Homo sapiens	100-111
29660161-1	2018	BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking.	Vitamin D	82-91	fibroblast growth factor 23	Homo sapiens	12-39
29660161-1	2018	BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking.	Vitamin D	82-91	fibroblast growth factor 23	Homo sapiens	41-47
28385183-3	2017	Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez in Mexico City.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	81-84
29660161-1	2018	BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking.	Vitamin D	82-91	klotho	Homo sapiens	53-59
28009432-1	2017	INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC).	Vitamin D	140-149	vitamin D receptor	Homo sapiens	14-32
29377305-1	2018	Calcium binding protein calbindin-D28K (CaBP28K) mediates the relationship between vitamin D and calcium, but its mechanism remains unclear during bone formation.	Vitamin D	83-92	calbindin 1	Mus musculus	24-28
28009432-1	2017	INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC).	Vitamin D	140-149	vitamin D receptor	Homo sapiens	34-37
28009432-1	2017	INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC).	Vitamin D	140-149	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	85-92
28009432-1	2017	INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC).	Vitamin D	164-173	vitamin D receptor	Homo sapiens	14-32
30217676-1	2018	Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism.	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	0-33
28009432-1	2017	INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC).	Vitamin D	164-173	vitamin D receptor	Homo sapiens	34-37
28009432-1	2017	INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC).	Vitamin D	164-173	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	85-92
27567005-10	2017	The active vitamin D hormone, 1,25(OH)2 D3 likely increased calcification in aortic smooth muscle cells perhaps by directly modulating expression of Alpl, Rankl, and Opg.	Vitamin D	11-20	alkaline phosphatase, liver/bone/kidney	Mus musculus	149-153
30405444-1	2018	Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and vitamin D metabolism.	Vitamin D	72-81	fibroblast growth factor 23	Mus musculus	0-27
27567005-10	2017	The active vitamin D hormone, 1,25(OH)2 D3 likely increased calcification in aortic smooth muscle cells perhaps by directly modulating expression of Alpl, Rankl, and Opg.	Vitamin D	11-20	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	166-169
30405444-1	2018	Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and vitamin D metabolism.	Vitamin D	72-81	fibroblast growth factor 23	Mus musculus	29-34
27584938-3	2017	We review the data that vitamin D, a pleiotropic hormone, is essential for Lgr5 stem cell functions by signaling through the vitamin D receptor.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	125-143
30405444-4	2018	We examined the folic acid-induced AKI (FA-AKI) mouse model to determine whether other organs contribute to the increase in plasma FGF23 and assessed the vitamin D axis as a possible trigger for increased Fgf23 gene expression.	Vitamin D	154-163	fibroblast growth factor 23	Mus musculus	205-210
27978548-2	2017	Objective: To investigate whether common variants in 7 vitamin D and calcium pathway genes (VDR, GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, and CASR) modify the effects of vitamin D3 or calcium supplementation on colorectal adenoma recurrence.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	92-95
30588186-6	2018	Our results show that melatonin and vitamin D are able to modulate ADSCs commitment towards osteogenic phenotype through the upregulation of HDAC1, SIRT 1 and 2, unfolding an epigenetic regulation in stem cell differentiation and opening novel strategies for future therapeutic balancing of stem cell fate toward adipogenic or osteogenic phenotype.	Vitamin D	36-45	sirtuin 1	Homo sapiens	148-160
30364193-7	2018	Notably, some of these regions harbor genes, such as CYP27A1, CYP2J2, GC, SNAI2, and PIM1, that are directly involved in vitamin D metabolic pathway.	Vitamin D	121-130	snail family transcriptional repressor 2	Bos taurus	74-79
28456639-6	2017	The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D.	Vitamin D	37-46	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
30296271-5	2018	Significant difference in the number of CCR7+ cells was observed in the EAT from vitamin D-deficient swine compared to vitamin D-sufficient or -supplemented swine.	Vitamin D	81-90	C-C motif chemokine receptor 7	Sus scrofa	40-44
30296271-5	2018	Significant difference in the number of CCR7+ cells was observed in the EAT from vitamin D-deficient swine compared to vitamin D-sufficient or -supplemented swine.	Vitamin D	119-128	C-C motif chemokine receptor 7	Sus scrofa	40-44
28456639-6	2017	The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D.	Vitamin D	171-180	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
28206978-3	2017	Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	146-164
28696084-2	2018	BACKGROUND: The presence of the vitamin D receptor (VDR) has been recently demonstrated in human muscle supporting the theory of a role of vitamin D in the proliferation and differentiation of muscle cells.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	52-55
29964038-9	2018	RESULTS: Vitamin D increased levels of UPP1 mRNA, protein, and enzymatic activity and increased vitamin D receptor binding to the UPP1 promoter in young adult mouse colonic cells, LS174T cells, and organoids.	Vitamin D	9-18	uridine phosphorylase 1	Mus musculus	39-43
29964038-9	2018	RESULTS: Vitamin D increased levels of UPP1 mRNA, protein, and enzymatic activity and increased vitamin D receptor binding to the UPP1 promoter in young adult mouse colonic cells, LS174T cells, and organoids.	Vitamin D	9-18	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	96-114
29964038-9	2018	RESULTS: Vitamin D increased levels of UPP1 mRNA, protein, and enzymatic activity and increased vitamin D receptor binding to the UPP1 promoter in young adult mouse colonic cells, LS174T cells, and organoids.	Vitamin D	9-18	uridine phosphorylase 1	Mus musculus	130-134
29964038-13	2018	CONCLUSIONS: We found vitamin D to increase expression of UPP1, leading to reduce uridine-induced DNA damage, in colon cells and organoids.	Vitamin D	22-31	uridine phosphorylase 1	Mus musculus	58-62
29964038-15	2018	Differences in expression of UPP1 in response to vitamin D could contribute to the increased risk of CRC in African Americans.	Vitamin D	49-58	uridine phosphorylase 1	Mus musculus	29-33
28425954-6	2017	We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	97-100
30364037-1	2018	The biologically active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D) and its receptor, the vitamin D receptor (VDR), play roles in maintaining oral immunity and the integrity of the periodontium.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	102-120
30364037-1	2018	The biologically active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D) and its receptor, the vitamin D receptor (VDR), play roles in maintaining oral immunity and the integrity of the periodontium.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	122-125
27989685-1	2017	BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses.	Vitamin D	52-61	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	119-137
30217807-1	2018	BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	12-39
30217807-1	2018	BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	41-46
30217807-12	2018	CONCLUSIONS: Common genetic variants located near genes involved in vitamin D metabolism and renal phosphate transport are associated with differences in circulating FGF23 concentrations.	Vitamin D	68-77	fibroblast growth factor 23	Homo sapiens	166-171
29885880-5	2018	RESULTS: The structurally related vitamin D analogs calcipotriol and tacalcitiol, but not calcitriol itself, suppressed HCV replication in a VDR-dependent manner.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	141-144
27989685-1	2017	BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses.	Vitamin D	52-61	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	139-142
28005440-13	2017	Vitamin D may decrease fasting C3.	Vitamin D	0-9	complement C3	Homo sapiens	31-33
28068558-1	2017	This study aimed to discover genetic variants in the entire 101 kB vitamin D receptor (VDR) gene for vitamin D deficiency in a group of postmenopausal Filipino women using targeted next generation sequencing (TNGS) approach in a case-control study design.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	87-90
29857077-3	2018	The VDR gene was found to regulate the immunomodulatory effects of vitamin D and it enhances the innate immunity system.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	4-7
29339180-11	2018	However, since it inhibits the conversion of 25(OH)D to 1,25(OH)2D and VDR mRNA long-term, it could decrease the vitamin D response in adipocytes, leading to greater adipogenesis.	Vitamin D	113-122	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	71-74
30208925-7	2018	The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform.	Vitamin D	60-69	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-96
30208925-7	2018	The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	128-131
28068558-9	2017	These findings show the power of TNGS in identifying sequence variations in a very large gene and the surprising results obtained in this study greatly expand the catalog of known VDR sequence variants that may represent an important clue in the emergence of vitamin D deficiency.	Vitamin D	259-268	vitamin D receptor	Homo sapiens	180-183
28089917-8	2017	Expression of the miR processing ribonuclease, DICER1, positively correlated with vitamin D metabolite levels in the clinical trial specimens.	Vitamin D	82-91	membrane associated ring-CH-type finger 8	Homo sapiens	18-21
30886976-0	2018	Vitamin D in individuals before onset of rheumatoid arthritis - relation to vitamin D binding protein and its associated genetic variants.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	76-101
28196884-0	2017	Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis .	Vitamin D	32-41	Cd4 molecule	Rattus norvegicus	53-56
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	37-46	sirtuin 1	Homo sapiens	58-63
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	37-46	sirtuin 1	Homo sapiens	114-119
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	104-113	sirtuin 1	Homo sapiens	58-63
28196884-4	2017	Using transcriptome, methylome, and pathway analyses in CD4+ T cells, we show that vitamin D affects multiple signaling and metabolic pathways critical for T-cell activation and differentiation into Th1 and Th17 subsets in vivo.	Vitamin D	83-92	Cd4 molecule	Rattus norvegicus	56-59
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	104-113	sirtuin 1	Homo sapiens	114-119
28196884-5	2017	Namely, Jak/Stat, Erk/Mapk, and Pi3K/Akt/mTor signaling pathway genes were down-regulated upon vitamin D supplementation.	Vitamin D	95-104	mechanistic target of rapamycin kinase	Rattus norvegicus	41-45
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	104-113	sirtuin 1	Homo sapiens	58-63
30271381-11	2018	The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.	Vitamin D	104-113	sirtuin 1	Homo sapiens	114-119
29183808-2	2018	Vitamin D exerts its genomic actions via the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D3 receptor	Cricetulus griseus	65-68
28245892-9	2017	The 9 % of children who reported taking vitamin D-containing supplements in the previous month had higher 25(OH)D concentrations (OR 6 9 nmol/l; 95 % CI 1 1, 12 7 nmol/l) relative to those who did not.	Vitamin D	40-49	olfactory receptor family 2 subfamily J member 4 pseudogene	Homo sapiens	130-136
30186518-9	2018	Key points: Vitamin D insufficiency prevalence is increasing worldwide and presents with similar comorbidities and risk factors to OSAS.The nonskeletal actions of vitamin D may contribute to the development of OSAS through immune system modulation, myopathy and inflammation.Studies evaluating serum vitamin D concentrations in OSAS patients and the effect of CPAP treatment report contradictory results, often influenced by confounding factors, such as obesity.There appears to be potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease, a comorbidity common in both conditions.	Vitamin D	12-21	centromere protein J	Homo sapiens	360-364
27732326-6	2017	Results: Two single nucleotide polymorphisms (SNPs), rs3755967 (GC) and rs11603330 (DHCR7), were associated with higher risk of low vitamin D status [odds ratio (95% confidence interval) per minor allele, 1.27 (1.18 to 1.36) and 1.16 (1.08 to 1.25), respectively].	Vitamin D	132-141	7-dehydrocholesterol reductase	Homo sapiens	84-89
30186518-9	2018	Key points: Vitamin D insufficiency prevalence is increasing worldwide and presents with similar comorbidities and risk factors to OSAS.The nonskeletal actions of vitamin D may contribute to the development of OSAS through immune system modulation, myopathy and inflammation.Studies evaluating serum vitamin D concentrations in OSAS patients and the effect of CPAP treatment report contradictory results, often influenced by confounding factors, such as obesity.There appears to be potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease, a comorbidity common in both conditions.	Vitamin D	163-172	centromere protein J	Homo sapiens	360-364
30018118-9	2018	Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment.Conclusions: In patients with NSCLC, vitamin D supplementation may improve survival of patients with early-stage lung adenocarcinoma with lower 25(OH)D levels.	Vitamin D	194-203	caudal type homeobox 2	Homo sapiens	55-59
28003380-2	2017	The active form of vitamin D [1,25(OH)2D] regulates B cells in vitro and mice without the vitamin D receptor (VDR knockout [KO]) have high serum IgE.	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	110-113
30274014-2	2018	Alteration of circulating vitamin D (VD) and its carrier vitamin D binding protein (VDBP) have been reported in certain types of cancers and may play a role in the course of the disease.	Vitamin D	26-35	GC vitamin D binding protein	Homo sapiens	57-82
30274014-2	2018	Alteration of circulating vitamin D (VD) and its carrier vitamin D binding protein (VDBP) have been reported in certain types of cancers and may play a role in the course of the disease.	Vitamin D	26-35	GC vitamin D binding protein	Homo sapiens	84-88
28003380-10	2017	Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.	Vitamin D	17-26	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	12-15
28065683-8	2017	DM1 and DM2 patients display a high frequency of skin abnormalities, the most common of which correlate with genotype severity and serum vitamin D levels.	Vitamin D	137-146	DM1 protein kinase	Homo sapiens	0-3
30150419-4	2018	However, several active metabolites of vitamin D can exert both direct action, mainly via vitamin D3 receptor trans-activation and indirect actions on several other tissues by an endocrine, autocrine and paracrine manners.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	90-109
27905210-1	2017	In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability.	Vitamin D	91-100	GC vitamin D binding protein	Homo sapiens	117-142
30246694-5	2018	RESULTS: Vitamin D supplementation significantly reduced the IL-17 and MDA serum levels (P&lt;0.05) and observably increased the TAC and IL-10 serum levels (P&lt;0.05), compared with the placebo group.	Vitamin D	9-18	interleukin 17A	Homo sapiens	61-66
30246694-5	2018	RESULTS: Vitamin D supplementation significantly reduced the IL-17 and MDA serum levels (P&lt;0.05) and observably increased the TAC and IL-10 serum levels (P&lt;0.05), compared with the placebo group.	Vitamin D	9-18	interleukin 10	Homo sapiens	137-142
29074824-2	2017	Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	170-188
30246694-6	2018	Comparing different bowel habit subtypes, we observed that it was only in diarrhea predominant IBS (IBS-D) that vitamin D supplementation was able to significantly reduce the serum levels of TNF-alpha and IL-17 (P&lt;0.05).	Vitamin D	112-121	interleukin 17A	Homo sapiens	205-210
30246694-7	2018	However, in all subtypes, IL-10 and TAC increased, while MDA decreased (P&lt;0.05) in vitamin D group, compared to the placebo group.	Vitamin D	86-95	interleukin 10	Homo sapiens	26-31
29074824-2	2017	Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	189-192
29074824-2	2017	Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	170-188
29074824-2	2017	Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	189-192
29996975-13	2018	CONCLUSIONS: An oral glucose load in vitamin D deficient patients with impaired glucose metabolism decreased FGF23 concentrations, which cannot be attributed to changes in insulin concentration.	Vitamin D	37-46	fibroblast growth factor 23	Homo sapiens	109-114
29074824-3	2017	The biological significance of 1alpha,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic beta cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	48-51
29074824-3	2017	The biological significance of 1alpha,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic beta cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others.	Vitamin D	273-282	vitamin D receptor	Homo sapiens	48-51
29074824-4	2017	Although 1alpha,25(OH)2D3-VDR signalling in classical target organs of vitamin D has been extensively studied, its precise function in these target organs still needs further investigation.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	26-29
29861059-1	2018	Fibroblast growth factor 23 (FGF23) is a proteohormone regulating renal phosphate transport and vitamin D metabolism as well as inducing left heart hypertrophy.	Vitamin D	96-105	fibroblast growth factor 23	Mus musculus	0-27
29861059-1	2018	Fibroblast growth factor 23 (FGF23) is a proteohormone regulating renal phosphate transport and vitamin D metabolism as well as inducing left heart hypertrophy.	Vitamin D	96-105	fibroblast growth factor 23	Mus musculus	29-34
29074825-6	2017	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3[1,25(OH)2D3], acts as a physiological VDR ligand, and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity, and cardiovascular function.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	98-101
27855629-2	2017	Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	30-33
30157946-2	2018	The aim of this study was to investigate if VDBP is affected by high dose vitamin D supplementation and if VDBP-levels correlate with free 25-OHD.	Vitamin D	74-83	GC vitamin D binding protein	Homo sapiens	44-48
27915991-2	2017	The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
29949513-2	2018	The circulating active form of vitamin D, 1,25-dihydroxyvitamin D, binds to the vitamin D receptor (VDR), which heterodimerizes with the retinoid X receptor to regulate the expression of target genes.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	80-98
29949513-2	2018	The circulating active form of vitamin D, 1,25-dihydroxyvitamin D, binds to the vitamin D receptor (VDR), which heterodimerizes with the retinoid X receptor to regulate the expression of target genes.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	100-103
29949513-2	2018	The circulating active form of vitamin D, 1,25-dihydroxyvitamin D, binds to the vitamin D receptor (VDR), which heterodimerizes with the retinoid X receptor to regulate the expression of target genes.	Vitamin D	31-40	retinoid X receptor alpha	Homo sapiens	137-156
28954273-4	2017	OBJECTIVE: To evaluate a possible regulatory effect of vitamin D on IL-17 and their relation to disease activity in vitiligo.	Vitamin D	55-64	interleukin 17A	Homo sapiens	68-73
29949513-3	2018	Inactivating mutations in the VDR gene cause hereditary vitamin D-resistant rickets (HVDRR), a rare disorder characterized by an early onset of rickets, growth retardation, skeletal deformities, hypocalcemia, hypophosphatemia and secondary hyperparathyroidism, and in some cases alopecia.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	30-33
30150596-0	2018	Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	84-102
30138371-3	2018	Therefore, we wanted to search for differences in expression of genes involved in the vitamin D receptor (VDR) activation pathway and genes that are known to alter upon vitamin D stimulation, in the aortic adventitia of CAD patients with and without RA.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	106-109
28954273-7	2017	Multivariable regression was performed to evaluate the relationship between IL-17 and vitamin D levels with the demographic data on the patients, revealing a nonsignificant relationship (p &gt; 0.05).	Vitamin D	86-95	interleukin 17A	Homo sapiens	76-81
30103977-1	2018	Vitamin D receptor (VDR) and its ligand Vitamin D, play a crucial role in regulating multiple pathways for maintaining vascular health.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	20-23
27033542-7	2017	There was a statistically significant inverse correlation between vitamin D status [defined by quartiles of measured values as well as commonly accepted cutoffs of serum 25(OH)D] and severity of the disease, as reflected by higher PTH and BSAP, but not by meeting the latest guidelines for parathyroidectomy.	Vitamin D	66-75	paired box 5	Homo sapiens	239-243
30093913-1	2018	Background: The aim in this study was to investigate the effect of vitamin D (25(OH)D3) supplementation on heat shock protein 60 (HSP 60) and other inflammatory markers (IL-17, TNF-alpha, PAB) in patients with coronary heart disease (CHD).	Vitamin D	67-76	heat shock protein family D (Hsp60) member 1	Homo sapiens	107-128
29264978-3	2017	Among the hypotheses of menstrual dysfunction with vitamin D deficiency, neurohumoral regulation of the hypothalamic-pituitary-ovarian system is considered to be essential due to the localization of vitamin D receptors (VDR), unlike other vitamins, in the nuclei of various tissues and organs.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	199-218
30093913-1	2018	Background: The aim in this study was to investigate the effect of vitamin D (25(OH)D3) supplementation on heat shock protein 60 (HSP 60) and other inflammatory markers (IL-17, TNF-alpha, PAB) in patients with coronary heart disease (CHD).	Vitamin D	67-76	heat shock protein family D (Hsp60) member 1	Homo sapiens	130-136
28293436-2	2017	Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties.	Vitamin D	37-46	GC vitamin D binding protein	Homo sapiens	0-25
30202762-1	2018	Objectives: To investigate if vitamin D receptor (VDR) gene polymorphisms and circulating vitamin D levels are associated with pelvic floor disorders (PFDs).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	50-53
30202762-8	2018	Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	147-150
30202762-8	2018	Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D.	Vitamin D	243-252	vitamin D receptor	Homo sapiens	147-150
28293436-7	2017	The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p &lt; 0.05, Student"s t-test) that were strongly associated with idiopathic fetal growth restriction (p &lt; 0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p = 0.295, Pearson"s correlation).	Vitamin D	61-70	GC vitamin D binding protein	Homo sapiens	259-284
26620085-1	2016	FGF23 is essential for the homeostasis of phosphate, and vitamin D.	Vitamin D	57-66	fibroblast growth factor 23	Homo sapiens	0-5
29936834-1	2018	We designed and synthesized vitamin D analogues with an electrophile as covalent modifiers for the vitamin D receptor (VDR).	Vitamin D	28-37	vitamin D receptor	Homo sapiens	99-117
29936834-1	2018	We designed and synthesized vitamin D analogues with an electrophile as covalent modifiers for the vitamin D receptor (VDR).	Vitamin D	28-37	vitamin D receptor	Homo sapiens	119-122
29936834-2	2018	Novel vitamin D analogues 1-4 have an electrophilic enone group at the side chain for conjugate addition to His301 or His393 in the VDR.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	132-135
29936834-9	2018	We successfully synthesized vitamin D analogues that form a covalent bond with VDR-LBD.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	79-82
27161894-13	2016	CONCLUSIONS: Restoration of vitamin D status of patients undergoing dialysis promoted upregulation of CYP27B1 and VDR expression in monocytes and a decrease in circulating inflammatory markers.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	114-117
29987250-0	2018	Vitamin D"s Effect on the Proliferation and Inflammation of Human Intervertebral Disc Cells in Relation to the Functional Vitamin D Receptor Gene FokI Polymorphism.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	122-140
26729468-1	2016	AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3.	Vitamin D	51-60	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-35
29986424-1	2018	The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and regulates calcium and bone metabolism.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
29420306-7	2018	Results While comparing the results of medium-high dose (5 mug/kg) and high dose (10 mug/kg) vitamin D administration to that of the control group, it was observed that serum antioxidant status and annexin V levels decreased and glomerular mesenchial matrix ratio increased in kidney (p&lt;0.05).	Vitamin D	93-102	annexin A5	Mus musculus	198-207
26729468-1	2016	AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3.	Vitamin D	51-60	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	158-163
26729468-1	2016	AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3.	Vitamin D	93-102	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-35
26729468-1	2016	AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3.	Vitamin D	93-102	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	158-163
29977597-1	2018	Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	146-165
27273785-10	2016	CONCLUSIONS: Vitamin D deficiency was associated with pulmonary function deficits among obese children, but not among normal-weight children with asthma, an association that was independent of Th1 and Th2 serum inflammatory measures.	Vitamin D	13-22	negative elongation factor complex member C/D	Homo sapiens	193-196
29977597-1	2018	Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	167-170
27879395-1	2016	Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of alpha-Klotho (alpha-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney.	Vitamin D	166-175	fibroblast growth factor 23	Mus musculus	29-35
29899561-2	2018	In this study, we found that at a physiological concentration, 25(OH)D3 (25D3), the precursor of 1,25D3 and an inactive form of vitamin D because of its much weaker binding activity to the vitamin D receptor (VDR) compared with 1,25D3, had a gene expression profile similar to that of 1,25D3 in prostate cancer LNCaP cells.	Vitamin D	128-137	vitamin D receptor	Homo sapiens	189-207
29946298-1	2018	Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/alpha-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism.	Vitamin D	180-189	fibroblast growth factor 23	Homo sapiens	0-27
29946298-1	2018	Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/alpha-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism.	Vitamin D	180-189	fibroblast growth factor 23	Homo sapiens	29-35
27879395-1	2016	Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of alpha-Klotho (alpha-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney.	Vitamin D	166-175	klotho	Mus musculus	90-102
27895587-4	2016	Vitamin D receptor (VDR) is highly expressed in the ileum of the small intestine, which prompted us to test a hypothesis that vitamin D signaling may determine the enterotype of gut microbiota through regulating the intestinal interface.	Vitamin D	126-135	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
29788141-1	2018	Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	67-85
29788141-1	2018	Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	87-90
27812184-2	2016	Fibroblast growth factor 23 (FGF23) is a hormone that inhibits vitamin D activation yet few studies examined whether FGF23 is associated with cognitive impairment.	Vitamin D	63-72	fibroblast growth factor 23	Homo sapiens	0-27
27812184-2	2016	Fibroblast growth factor 23 (FGF23) is a hormone that inhibits vitamin D activation yet few studies examined whether FGF23 is associated with cognitive impairment.	Vitamin D	63-72	fibroblast growth factor 23	Homo sapiens	29-34
29634094-1	2016	The pleiotropism of vitamin D is due to the presence of vitamin D receptor in the cells of nearly all tissues and organs within the human body, including the CNS.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	56-74
29634094-12	2016	Vitamin D is worth consideration since by inducing the expression of VDR gene it leads, among others, to the silencing of the transcription of the gene encoding the AOAPP and thus inhibits its cleavage into peptides that form amyloid deposits.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	69-72
27098343-10	2016	When administered together with endogenous vitamin D metabolites, dexamethasone and efavirenz counteracted the 1,25D3 -mediated up-regulation of CYP24A1, which inactivates 1,25D3 .	Vitamin D	43-52	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-152
29874855-1	2018	Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	0-18
29874855-1	2018	Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	20-23
27357804-0	2016	Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor alpha.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	110-135
29922235-1	2018	Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	0-18
29922235-1	2018	Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	20-23
26906498-8	2016	A correlation analysis demonstrated that endocan levels were positively correlated with body mass index (BMI), thyroid-stimulating hormone (TSH), anti-thyroid peroxidase, and anti-thyroglobulin and negatively correlated with free thyroid hormone 4 (FT4) and vitamin D levels.	Vitamin D	258-267	endothelial cell specific molecule 1	Homo sapiens	41-48
29767851-7	2018	Lower 25-OHD levels were also associated with increased expression of CYP3A4, and with decreased expression of GC (also termed DBP) and VDR, three genes involved in vitamin D metabolism.	Vitamin D	165-174	vitamin D receptor	Homo sapiens	136-139
29726119-7	2018	Additionally, genotyping of 296 SNPs in the same subjects resulted in findings that 27 SNPs, predominantly in CYP24A1 and VDR genes, were significantly associated with lung cancer status, affected mRNA expression, and modulated vitamin D levels.	Vitamin D	228-237	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	110-117
27454349-6	2016	Expert opinion: There is an increasing appreciation of the impact of vitamin D and its receptor VDR not only in bone biology, but also for metabolic diseases, immunological disorders, and cancer.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	96-99
29726119-7	2018	Additionally, genotyping of 296 SNPs in the same subjects resulted in findings that 27 SNPs, predominantly in CYP24A1 and VDR genes, were significantly associated with lung cancer status, affected mRNA expression, and modulated vitamin D levels.	Vitamin D	228-237	vitamin D receptor	Homo sapiens	122-125
29452294-3	2018	We evaluated the impact of polymorphisms in genes (CYP27B1, CYP24A1, VDBP and VDR) related to vitamin D pathway on sofosbuvir and GS-331007 plasma levels in HCV mono-infected patients at one month of treatment.	Vitamin D	94-103	GC vitamin D binding protein	Homo sapiens	69-73
29452294-3	2018	We evaluated the impact of polymorphisms in genes (CYP27B1, CYP24A1, VDBP and VDR) related to vitamin D pathway on sofosbuvir and GS-331007 plasma levels in HCV mono-infected patients at one month of treatment.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	78-81
27535015-3	2016	Polymorphisms in vitamin D receptor (VDR) gene can influence the expression of vitamin D in individuals.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
29778131-2	2018	Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	0-18
27898971-8	2016	From d 0 to 35 in the nursery, pigs from sows fed increasing vitamin D had increased (quadratic, &lt; 0.003) ADG and ADFI, but G:F was similar regardless of maternal vitamin D regimen.	Vitamin D	61-70	ADG	Sus scrofa	109-112
29778131-2	2018	Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	20-23
29778131-9	2018	CONCLUSIONS: VDR is an important receptor in the pathogenesis of UC, and optimizing vitamin D levels could have a therapeutic role in UC.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	13-16
29217467-5	2018	In the circulation, vitamin D - like other steroid hormones - is bound tightly to a special carrier - vitamin D-binding protein (DBP).	Vitamin D	20-29	GC vitamin D binding protein	Homo sapiens	102-127
26343449-2	2016	As the VDR is widely distributed in nearly all cells of the body, it implies that the vitamin D endocrine system may regulate many cell types and functions.	Vitamin D	86-95	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	7-10
26523676-6	2016	Primary and secondary vitamin D target genes being up- and down-regulated were related to changes in the epigenome of THP-1 cells, such as 1,25(OH)2D3-dependent chromatin opening and modulation of the genome-wide association of the transcription factors VDR and CCCTC-binding factor (CTCF) with their respective genomic binding sites.	Vitamin D	22-31	CCCTC-binding factor	Homo sapiens	262-282
29130299-2	2018	A nuclear receptor (VDR) mediates vitamin D actions in a lot of organs like bowel, bone, kidney, breast, gonads, pancreas, brain, cardiovascular and immune systems.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	20-23
26523676-6	2016	Primary and secondary vitamin D target genes being up- and down-regulated were related to changes in the epigenome of THP-1 cells, such as 1,25(OH)2D3-dependent chromatin opening and modulation of the genome-wide association of the transcription factors VDR and CCCTC-binding factor (CTCF) with their respective genomic binding sites.	Vitamin D	22-31	CCCTC-binding factor	Homo sapiens	284-288
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	7-dehydrocholesterol reductase	Homo sapiens	182-187
29538679-12	2018	WIDER IMPLICATIONS OF THE FINDINGS: This study suggests that there is a relationship between AGEs and their receptors (RAGE and sRAGE) with vitamin D.	Vitamin D	140-149	long intergenic non-protein coding RNA 914	Homo sapiens	119-123
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	239-246
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	vitamin D receptor	Homo sapiens	248-251
26686945-3	2016	We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	157-166	retinoid X receptor alpha	Homo sapiens	256-260
27554639-7	2016	A reduction in TAZ can also enhance the sensitivity of tumor cells to vitamin D by regulating the p53/CYP24A1 pathway.	Vitamin D	70-79	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	102-109
29790402-1	2018	AIM: Vitamin D (VD) influences genetic expression through its receptor (VDR).	Vitamin D	5-14	vitamin D receptor	Homo sapiens	72-75
27803671-3	2016	The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D3), bound to its receptor, the vitamin D receptor (VDR) regulates the expression of hundreds of different genes in a cell- and tissue-specific manner.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	95-113
29501468-13	2018	In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-gamma.	Vitamin D	24-33	interleukin 10	Homo sapiens	76-81
29881333-6	2018	Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression of the tight junction protein between adjacent epithelial cells and the percentages of CD4+CD25+Foxp3+Treg cell in spleen and mesenteric lymph nodes.	Vitamin D	0-9	CD4 antigen	Mus musculus	193-196
30134801-0	2018	Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study.	Vitamin D	32-41	fibroblast growth factor 23	Homo sapiens	26-31
30134801-3	2018	We therefore sought evidence for dysregulation of the PTH-FGF23-vitamin D axis in RRMS.	Vitamin D	64-73	fibroblast growth factor 23	Homo sapiens	58-63
30134801-12	2018	CONCLUSIONS: This study revealed a dysequilibrium of the PTH-FGF23-vitamin D axis in RRMS, with lower plasma PTH, higher plasma iFGF23 and a lower serum 1,25(OH)2D to 25OHD ratio in RRMS compared with HC subjects.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	61-66
27803671-3	2016	The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D3), bound to its receptor, the vitamin D receptor (VDR) regulates the expression of hundreds of different genes in a cell- and tissue-specific manner.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	115-118
27477355-1	2016	Vitamin D was found to be involved in liver fibrosis modulation through binding to its receptor (VDR) halting many fibrotic pathways.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
29760049-1	2018	Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy.	Vitamin D	96-105	fibroblast growth factor 23	Homo sapiens	0-27
29760049-1	2018	Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy.	Vitamin D	96-105	fibroblast growth factor 23	Homo sapiens	29-34
27477355-2	2016	Targeting vitamin D-VDR axis using vitamin D analogs may represent an efficient strategy for liver fibrosis treatment .	Vitamin D	10-19	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
29886473-4	2018	The increased FGF23 levels gradually lead to myocardial hypertrophy, inflammatory, vascular calcification, and low level of vitamin D, which contribute to the progress of CKD, cardiovascular complications and even death.	Vitamin D	124-133	fibroblast growth factor 23	Homo sapiens	14-19
27725127-0	2016	Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients.	Vitamin D	0-9	interleukin 17A	Homo sapiens	30-35
27785371-9	2016	Osteoclast fusion transcripts transmembrane 7 subfamily member 4 (tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1 (nfatc1) where downregulated in response to vitamin D metabolites.	Vitamin D	171-180	nuclear factor of activated T cells 1	Homo sapiens	78-126
29910802-10	2018	Vitamin D levels were insufficient in 50% of old individuals and correlated positively with total CD8+ T cells and negatively with CD8+ EMRA T cells.	Vitamin D	0-9	CD8a molecule	Homo sapiens	98-101
29910802-10	2018	Vitamin D levels were insufficient in 50% of old individuals and correlated positively with total CD8+ T cells and negatively with CD8+ EMRA T cells.	Vitamin D	0-9	CD8a molecule	Homo sapiens	131-134
27785371-9	2016	Osteoclast fusion transcripts transmembrane 7 subfamily member 4 (tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1 (nfatc1) where downregulated in response to vitamin D metabolites.	Vitamin D	171-180	nuclear factor of activated T cells 1	Homo sapiens	128-134
29910802-12	2018	Considering the limitations of the study as size of the sample and lack of functional assays, it was found that vitamin D in old individuals was correlated to some features of the immune system, mainly in the CD8 compartment.	Vitamin D	112-121	CD8a molecule	Homo sapiens	209-212
27495287-8	2016	RESULTS: After 6 weeks of oral sodium bicarbonate, the median FGF23 increased significantly from 150.9 RU/mL (IQR 107.7-267.43) to 191.4 RU/mL (IQR 132.6-316.9) (p = 0.048) and this persisted after excluding participants who received activated vitamin D.	Vitamin D	244-253	fibroblast growth factor 23	Homo sapiens	62-67
29432829-3	2018	With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	93-111
29432829-3	2018	With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	113-116
27215149-1	2016	INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn.	Vitamin D	86-95	fibroblast growth factor 23	Homo sapiens	14-41
29720668-1	2018	Fibroblast growth factor 23 (FGF23) plays critical roles in phosphate handling and vitamin D metabolism in the kidney.	Vitamin D	83-92	fibroblast growth factor 23	Mus musculus	0-27
29720668-1	2018	Fibroblast growth factor 23 (FGF23) plays critical roles in phosphate handling and vitamin D metabolism in the kidney.	Vitamin D	83-92	fibroblast growth factor 23	Mus musculus	29-34
27215149-1	2016	INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn.	Vitamin D	86-95	fibroblast growth factor 23	Homo sapiens	43-48
28164608-1	2016	BACKGROUND: The actions of Vitamin D in different tissues, including breast tissue, are mediated by vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	100-118
29519954-2	2018	We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	110-137
29519954-2	2018	We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	139-144
28164608-1	2016	BACKGROUND: The actions of Vitamin D in different tissues, including breast tissue, are mediated by vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	120-123
26302679-0	2016	Granuloma formation after oil-soluble vitamin D injection for lip augmentation - case report.	Vitamin D	38-47	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	62-65
27338176-1	2016	OBJECTIVE: Vitamin D acts through vitamin D receptor (VDR) and has promising beneficial effects in the development and progression of multiple sclerosis (MS).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	34-52
27338176-1	2016	OBJECTIVE: Vitamin D acts through vitamin D receptor (VDR) and has promising beneficial effects in the development and progression of multiple sclerosis (MS).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	54-57
27471592-2	2016	The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	211-214
27471592-2	2016	The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process.	Vitamin D	67-76	ORAI calcium release-activated calcium modulator 1	Homo sapiens	316-321
30603307-7	2017	Vitamin D deficiency augmented the decreases in Pax7 mRNA levels and the increases in muscle RING-Finger Protein-1 and atrogin-1 mRNA levels induced by diabetes in the gastrocnemius muscle of mice.	Vitamin D	0-9	paired box 7	Mus musculus	48-52
30603307-7	2017	Vitamin D deficiency augmented the decreases in Pax7 mRNA levels and the increases in muscle RING-Finger Protein-1 and atrogin-1 mRNA levels induced by diabetes in the gastrocnemius muscle of mice.	Vitamin D	0-9	tripartite motif-containing 63	Mus musculus	86-114
27306067-15	2016	Vitamin D may have a limited effect on CD8+ T cells by decreasing interferon-gamma expression.	Vitamin D	0-9	CD8a molecule	Homo sapiens	39-42
27307163-2	2016	Established vitamin D effects are renal and intestinal resorption of calcium and phosphate for optimal bone mineral density; however, the widespread distribution of the vitamin D receptor (VDR), a member of the nuclear steroid hormone receptor family, provides extensive evidence for additional pleiotropic effects of the vitamin D ligand.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	169-187
27307163-2	2016	Established vitamin D effects are renal and intestinal resorption of calcium and phosphate for optimal bone mineral density; however, the widespread distribution of the vitamin D receptor (VDR), a member of the nuclear steroid hormone receptor family, provides extensive evidence for additional pleiotropic effects of the vitamin D ligand.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	189-192
27307163-2	2016	Established vitamin D effects are renal and intestinal resorption of calcium and phosphate for optimal bone mineral density; however, the widespread distribution of the vitamin D receptor (VDR), a member of the nuclear steroid hormone receptor family, provides extensive evidence for additional pleiotropic effects of the vitamin D ligand.	Vitamin D	169-178	vitamin D receptor	Homo sapiens	189-192
27154546-2	2016	Vitamin D-dependent rickets type II (VDDRII) is a congenital disease caused by inactivating mutations in the VDR The condition is treated with high doses of calcitriol, but the therapeutic effects of other synthetic VD3 analogs have not yet been investigated.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	109-112
27239732-15	2016	The anti-inflammatory potential of VDR activation in vitamin D insufficient patients is highly selective and appears to be mediated by an effect on calcineurin-mediated responses.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	35-38
26939683-0	2016	Fibroblast growth factor-23 and renin-angiotensin system levels in vitamin-D-dependent rickets type I.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	0-37
26864938-2	2016	Initially discovered as a regulator of phosphate and vitamin D homeostasis, FGF23 has now been implicated in several pathophysiological mechanisms that may negatively impact the cardiovascular and renal systems.	Vitamin D	53-62	fibroblast growth factor 23	Homo sapiens	76-81
27272846-0	2016	Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes.	Vitamin D	21-30	BRCA1 DNA repair associated	Homo sapiens	80-85
27272846-0	2016	Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes.	Vitamin D	21-30	BRCA2 DNA repair associated	Homo sapiens	89-94
27272846-3	2016	The purpose of this investigation was to evaluate the association of thyroid gland function and vitamin D with BC in patients with BRCA mutations.	Vitamin D	96-105	BRCA1 DNA repair associated	Homo sapiens	131-135
27272846-8	2016	A significantly increased level of vitamin D in BRCA2-mutation carriers compared to those without mutation (p=0.02) was detected.	Vitamin D	35-44	BRCA2 DNA repair associated	Homo sapiens	48-53
27272846-12	2016	Vitamin D was significantly elevated in BRCA2-mutation carriers and the observation of a better tumor grade in this group could be consistent with the ability of vitamin D to inhibit growth and induce differentiation.	Vitamin D	0-9	BRCA2 DNA repair associated	Homo sapiens	40-45
27272846-12	2016	Vitamin D was significantly elevated in BRCA2-mutation carriers and the observation of a better tumor grade in this group could be consistent with the ability of vitamin D to inhibit growth and induce differentiation.	Vitamin D	162-171	BRCA2 DNA repair associated	Homo sapiens	40-45
27065588-0	2016	Vitamin D Receptor (VDR) Gene Polymorphisms (FokI, BsmI) and their Relation to Vitamin D Status in Pediatrics betaeta Thalassemia Major.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	20-23
27065588-3	2016	Expression and activation of the vitamin D receptor (VDR) are necessary for the effects of vitamin D, in which several single nucleotide polymorphisms have been identified especially (FokI, BsmI).	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
27065588-9	2016	In conclusion, these results suggest that the VDR (FokI, BsmI) gene polymorphisms influence vitamin D status, (Ff,ff), BB genotypes had lower vitamin D levels, so they might influence risk of development of bone diseases in beta thalassemia major.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	46-49
27065588-9	2016	In conclusion, these results suggest that the VDR (FokI, BsmI) gene polymorphisms influence vitamin D status, (Ff,ff), BB genotypes had lower vitamin D levels, so they might influence risk of development of bone diseases in beta thalassemia major.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	46-49
27139837-6	2016	Among vitamin D pathway gene polymorphisms, VDR FokI T&gt;C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	44-47
27403909-2	2016	FGF23 together with its cofactor, alpha-Klotho protein, plays a pivotal role in calcium-phosphorus metabolism in patients with CKD by decreasing secretion of active metabolite of vitamin D and antagonizing phosphate resorption in renal tubules.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	0-5
26715761-0	2016	Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF.	Vitamin D	26-35	CCCTC-binding factor	Homo sapiens	101-105
26715761-1	2016	The physiological functions of vitamin D are mediated by its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	152-170
26715761-1	2016	The physiological functions of vitamin D are mediated by its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	172-175
27245104-1	2016	In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	107-125
27245104-1	2016	In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	127-130
27245104-2	2016	Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	42-49
27245104-2	2016	Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D.	Vitamin D	130-139	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	42-49
27245104-2	2016	Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D.	Vitamin D	130-139	vitamin D receptor	Homo sapiens	67-70
27041081-6	2016	Both forms of vitamin D reduced the expression of pathogenic Th17 markers and their secretion of pro-inflammatory cytokines (IL-17A, IFN-gamma).	Vitamin D	14-23	interleukin 17A	Homo sapiens	125-131
27052925-1	2016	BACKGROUND AND AIMS: 1alpha,25-dihydroxyvitamin-D3, the biologically active vitamin D, plays a central role in several metabolic pathways through the binding to the vitamin D receptor (VDR).	Vitamin D	76-85	vitamin D receptor	Homo sapiens	165-183
28673024-8	2018	A CYP3A43 genotype, previously implicated in cancer, is strongly associated with biomarkers of vitamin D metabolism.	Vitamin D	95-104	cytochrome P450 family 3 subfamily A member 43	Homo sapiens	2-9
27052925-1	2016	BACKGROUND AND AIMS: 1alpha,25-dihydroxyvitamin-D3, the biologically active vitamin D, plays a central role in several metabolic pathways through the binding to the vitamin D receptor (VDR).	Vitamin D	76-85	vitamin D receptor	Homo sapiens	185-188
27001276-10	2016	Taken together, we provide evidence that vitamin D balance in the presence of hyperglycemia is strongly associated with serum adiponectin levels and reduced renal renin-angiotensin system signaling.	Vitamin D	41-50	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	126-137
27114922-1	2016	INTRODUCTION: We studied the frequencies of the 3" and 5"-end vitamin D receptor (VDR) gene polymorphisms and their correlation with bone mineral density (BMD) in Egyptian pediatric acute lymphoblastic leukemia (ALL) patients receiving calcium and vitamin D supplements.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	82-85
28994020-3	2018	Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	141-159
27114922-2	2016	The purpose of this study is to find out the relation between VDR polymorphism and the response to vitamin D intake in pediatric ALL cases who receive corticosteroid therapy which predispose to osteoporosis.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	62-65
29392411-0	2018	Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D.	Vitamin D	115-124	interleukin 9	Mus musculus	62-75
27134818-2	2016	Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with "traditional" feedback loops for mineral metabolism.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	57-84
28892641-3	2018	Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn might affect its serum levels and CAD incidence.	Vitamin D	48-57	GC vitamin D binding protein	Homo sapiens	0-25
28892641-3	2018	Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn might affect its serum levels and CAD incidence.	Vitamin D	48-57	GC vitamin D binding protein	Homo sapiens	27-31
27134818-2	2016	Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with "traditional" feedback loops for mineral metabolism.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	86-91
26932723-7	2016	The differentially expressed genes are not all direct targets of the vitamin D-VDR pathway and it appears that vitamin D action engages in the crosstalk with estrogen and insulin signaling.	Vitamin D	69-78	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	79-82
26774929-8	2016	For the first time, we showed that calcitroic acid, the assumed inactive final metabolite of vitamin D, was able to activate VDR-mediated transcription to a higher magnitude than bile acid LCA.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	125-128
29458003-0	2018	FGF 23, PTH and vitamin D status in end stage renal disease patients affected by VDR FokI and BsmI variants.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	81-84
26315479-0	2016	A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults.	Vitamin D	31-40	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	57-64
29435763-1	2018	Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)2D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	196-214
29435763-1	2018	Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)2D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	216-219
28808527-4	2016	The present ligand is the first secosteroidal analog with the carborane unit that efficiently binds to VDR and functions as an agonist with 1,25D-like potency in transcriptional assay on vitamin D target genes.	Vitamin D	187-196	vitamin D receptor	Homo sapiens	103-106
29435763-9	2018	These actions demonstrate the critical role of vitamin D in regulating skeletal homeostasis both indirectly and directly via the 1,25(OH)2D/VDR system.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	140-143
26784540-1	2016	Overexpression of FGF23 results in hypophosphatemic rickets, which is characterized by renal phosphate wasting, inappropriately low circulating levels of the active form of vitamin D, and skeletal abnormalities.	Vitamin D	173-182	fibroblast growth factor 23	Homo sapiens	18-23
26784540-3	2016	In this issue of the JCI, Bai and colleagues demonstrate that deletion or inhibition of CYP24A1, which initiates degradation of the active form of vitamin D, ameliorates skeletal abnormalities in two mouse models of hypophosphatemic rickets.	Vitamin D	147-156	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	88-95
26446365-1	2016	Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	89-107
26446365-1	2016	Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	109-112
26501157-4	2016	Clinicians should be aware that even therapeutic doses of vitamin D can prove harmful for patients with CYP24A1 mutations.	Vitamin D	58-67	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
26238339-2	2016	We hypothesised that cells overexpressing CYP24A1 have growth advantage and a diet rich in vitamin D and soy would restore sensitivity to the anti-tumourigenic effects of vitamin D.	Vitamin D	171-180	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	42-49
26355700-1	2015	Active forms of vitamin D regulate the expression of multiple genes that play essential roles in calcium and phosphate homeostasis, cell differentiation, and the immune system via the vitamin D receptor (VDR).	Vitamin D	16-25	vitamin D receptor	Homo sapiens	184-202
26355700-1	2015	Active forms of vitamin D regulate the expression of multiple genes that play essential roles in calcium and phosphate homeostasis, cell differentiation, and the immune system via the vitamin D receptor (VDR).	Vitamin D	16-25	vitamin D receptor	Homo sapiens	204-207
26355700-7	2015	Our results on chimeric luciferases containing the LBDs of mutant VDRs derived from patients with vitamin D-dependent type II rickets indicated that our system could detect a conformational change of the LBD of the VDR likely based on a positional change of the helix 12, which occurs upon ligand binding.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	66-69
26501255-12	2015	We also suggest that vitamin D-based therapies may represent an adjuvant strategy in treatment for bladder cancers expressing VDR.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	126-129
26196951-1	2015	CONTEXT: Vitamin D binding protein (DBP) is an important determinant of bioavailable vitamin D (BAVD) and may provide clues to racial variation in osteoporosis and atherosclerosis.	Vitamin D	85-94	GC vitamin D binding protein	Homo sapiens	9-34
25878189-5	2015	The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	4-7
26422470-1	2015	Hereditary 1, 25-dihydroxyvitamin D-resistant rickets (HVDRR), a rare recessive disease, is caused by mutation in the VDR gene encoding the vitamin D receptor leading to the resistance to vitamin D.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	140-158
26276877-2	2015	IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells.	Vitamin D	64-73	interleukin 10	Homo sapiens	0-5
26276877-3	2015	In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner.	Vitamin D	56-65	interleukin 10	Homo sapiens	237-242
26346690-1	2015	BACKGROUND: Polymorphisms in the vitamin D receptor (VDR) gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
25931412-5	2015	Active vitamin D analogs, capable of binding the vitamin D receptor evoking vitamin D-related biological effects, are mandatorily employed in hypoparathyroidism and kidney failure with impaired 1alpha-hydroxylation.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	49-67
25641222-8	2015	Vitamin D analogues may provide a therapeutic choice for patients with high VDR expression in tumours but a low vitamin D level in the circulation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	76-79
26637501-9	2015	Also, anti-TPO levels were significantly higher in 186/218 vitamin D deficient HT patients compared to 32/218 HT patients with no vitamin D deficiency (364 +- 181IU/mL versus 115.8 +- 37.1IU/mL, P&lt;0.0001).	Vitamin D	59-68	thyroid peroxidase	Homo sapiens	11-14
26637501-9	2015	Also, anti-TPO levels were significantly higher in 186/218 vitamin D deficient HT patients compared to 32/218 HT patients with no vitamin D deficiency (364 +- 181IU/mL versus 115.8 +- 37.1IU/mL, P&lt;0.0001).	Vitamin D	130-139	thyroid peroxidase	Homo sapiens	11-14
26637501-10	2015	Supplementation of CF in 186 vitamin D deficient HT patients caused a significant decrease (20.3%) in serum anti-TPO levels.	Vitamin D	29-38	thyroid peroxidase	Homo sapiens	113-116
26637501-14	2015	After 4 months of CF supplementation in the 186 HT patients with vitamin D deficiency, a significant decrease (20.3%) of serum anti-TPO levels was found.	Vitamin D	65-74	thyroid peroxidase	Homo sapiens	132-135
26348637-10	2015	The results strengthen the hypothesis that megalin and cubilin are likely involved in the secretory pathway of vitamin D into tear fluid by the duct cells.	Vitamin D	111-120	cubilin (intrinsic factor-cobalamin receptor)	Mus musculus	55-62
25748032-2	2015	Vitamin D also regulates mineral homeostasis and upregulates klotho expression.	Vitamin D	0-9	klotho	Homo sapiens	61-67
25168424-5	2015	Active vitamin D sterols increase FGF23 levels, whereas therapy with calcimimetics decreases FGF23 levels.	Vitamin D	7-16	fibroblast growth factor 23	Homo sapiens	34-39
26184408-2	2015	By binding the active vitamin D hormone to the vitamin D receptor (VDR), it acts as a nuclear transcription factor (Bouillon et al., Endocr Rev 29(6):726-776, 2008).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	47-65
25873267-0	2015	Effect of Cinacalcet and Vitamin D Analogs on Fibroblast Growth Factor-23 during the Treatment of Secondary Hyperparathyroidism.	Vitamin D	25-34	fibroblast growth factor 23	Homo sapiens	46-73
25873267-10	2015	Changes in FGF-23 in the vitamin D analog but not the cinacalcet arm were correlated with changes in Ca (cinacalcet: r=0.11, P=0.30; vitamin D analog: r=0.32, P&lt;0.01) and P (cinacalcet: r=0.19, P=0.07; vitamin D analog: r=0.49, P&lt;0.001).	Vitamin D	25-34	fibroblast growth factor 23	Homo sapiens	11-17
25873267-10	2015	Changes in FGF-23 in the vitamin D analog but not the cinacalcet arm were correlated with changes in Ca (cinacalcet: r=0.11, P=0.30; vitamin D analog: r=0.32, P&lt;0.01) and P (cinacalcet: r=0.19, P=0.07; vitamin D analog: r=0.49, P&lt;0.001).	Vitamin D	133-142	fibroblast growth factor 23	Homo sapiens	11-17
25873267-10	2015	Changes in FGF-23 in the vitamin D analog but not the cinacalcet arm were correlated with changes in Ca (cinacalcet: r=0.11, P=0.30; vitamin D analog: r=0.32, P&lt;0.01) and P (cinacalcet: r=0.19, P=0.07; vitamin D analog: r=0.49, P&lt;0.001).	Vitamin D	133-142	fibroblast growth factor 23	Homo sapiens	11-17
25873267-11	2015	Changes in FGF-23 were correlated with changes in CaxP in both arms (cinacalcet: r=0.26, P=0.01; vitamin D analog: r=0.57, P&lt;0.001).	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	11-17
25873267-15	2015	It is possible that effects of cinacalcet and vitamin D analogs on FGF-23 may be mediated indirectly by other effects on bone and mineral metabolism.	Vitamin D	46-55	fibroblast growth factor 23	Homo sapiens	67-73
26046642-4	2015	The goal of this study was to determine the prevalence of vitamin D deficiency (hypovitaminosis D) and its association with serum calcium, phosphorus, and parathyroid hormone (PTH) concentrations, disease severity, and mortality in hospitalized newborn foals.	Vitamin D	58-67	parathyroid hormone	Equus caballus	155-174
26009175-4	2015	This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways.	Vitamin D	5-14	klotho	Homo sapiens	100-106
26009175-4	2015	This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways.	Vitamin D	61-70	klotho	Homo sapiens	100-106
25938686-0	2015	Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	87-90
29428204-2	2018	And 24-hydroxylase encoded by CYP24A1 is the very enzyme that degrades the active vitamin D metabolite.	Vitamin D	82-91	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
25510525-1	2015	Vitamin D is associated with skeletal muscle physiology and function and may play a role in intramuscular inflammation, possibly via the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	137-155
29549592-5	2018	In the present study, we evaluated vitamin D serum concentration as well as expression of vitamin D receptor (VDR) gene and genes encoding for vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1) and deactivating enzyme 24-hyroxylase (CYP24A1) in epileptic patients compared with healthy individuals.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	110-113
29229305-0	2018	Expression and shedding of CD44 in the endometrium of women with endometriosis and modulating effects of vitamin D: A randomized exploratory trial.	Vitamin D	105-114	CD44 molecule (Indian blood group)	Homo sapiens	27-31
29371396-2	2018	The mitochondrial P450 24A1 (CYP24A1) is responsible for deactivation of the bioactive form of vitamin D, 1,25(OH)2D3.	Vitamin D	95-104	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	29-36
25510525-1	2015	Vitamin D is associated with skeletal muscle physiology and function and may play a role in intramuscular inflammation, possibly via the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	157-160
25536521-10	2015	The results of this study elucidate a possible pathway for crosstalk between two nutritionally derived lipids, vitamin D and resveratrol, both of which converge on VDR signaling.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	164-167
29593729-8	2018	The development of new genetic tools using next-generation sequencing: e.g., chromatin immunoprecipitation sequencing (ChIP-seq) and the accompanying rapid progress of epigenomics has made it possible to recognize that the association between vitamin D and MS could be based on the extensive and characteristic genomic binding of the vitamin D receptor (VDR).	Vitamin D	243-252	vitamin D receptor	Homo sapiens	334-352
29593729-8	2018	The development of new genetic tools using next-generation sequencing: e.g., chromatin immunoprecipitation sequencing (ChIP-seq) and the accompanying rapid progress of epigenomics has made it possible to recognize that the association between vitamin D and MS could be based on the extensive and characteristic genomic binding of the vitamin D receptor (VDR).	Vitamin D	243-252	vitamin D receptor	Homo sapiens	354-357
29599772-0	2018	The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23.	Vitamin D	39-48	fibroblast growth factor 23	Mus musculus	68-95
29599772-11	2018	The microbiota through FGF23 regulates vitamin D metabolism.	Vitamin D	39-48	fibroblast growth factor 23	Mus musculus	23-28
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	interleukin 10	Homo sapiens	90-95
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	interleukin 17A	Homo sapiens	96-102
29324259-9	2018	RESULTS: Higher serum vitamin D levels positively correlated with higher ratios of IL-4 + IL-10/IL-17A + TNF-alpha (r = 0.37, P &lt; .01), and IL-4 + IL-10/IL-6 + TNF-alpha (r = 0.32, P &lt; .01).	Vitamin D	22-31	interleukin 10	Homo sapiens	150-155
28874334-10	2018	Further identification of as many disease-causing mutations in the CYP24A1 gene as possible can help identification of predisposed individuals in whom vitamin-D supplementation should be reconsidered.	Vitamin D	151-160	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	67-74
29416576-0	2018	Association of SIRT-1 Gene Polymorphism and Vitamin D Level in Egyptian Patients With Rheumatoid Arthritis.	Vitamin D	44-53	sirtuin 1	Homo sapiens	15-21
29416576-1	2018	Background: We investigated SIRT-1 genetic variant and its association with vitamin D level in Egyptian patients with rheumatoid arthritis (RA).	Vitamin D	76-85	sirtuin 1	Homo sapiens	28-34
26155287-1	2015	PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	108-126
28795342-0	2018	Effect of Cholecalciferol therapy on serum FGF23 in vitamin D deficient patients: a randomized clinical trial.	Vitamin D	52-61	fibroblast growth factor 23	Homo sapiens	43-48
28795342-2	2018	However, the effect of Cholecalciferol therapy on FGF23 serum level in patients with vitamin D deficiency has not been studied, yet.	Vitamin D	85-94	fibroblast growth factor 23	Homo sapiens	50-55
28795342-6	2018	However, delta values of serum 25(OH)D3, 1,25(OH)2D3 and FGF23 in vitamin D treated group were more than the placebo-treated ones (P &lt; 0.001, P = 0.002, and P = 0.04, respectively).	Vitamin D	66-75	fibroblast growth factor 23	Homo sapiens	57-62
26155287-1	2015	PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	128-131
25377645-2	2015	As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	39-42
28602960-3	2018	Mutations in human VDR (hVDR) cause hereditary vitamin D resistant rickets, a genetic syndrome characterized by hypocalcemia, hyperparathyroidism and rickets resulting from dysregulation of mineral homeostasis.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	19-22
28870774-2	2018	VDR is the nuclear receptor for the biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	61-70	vitamin D receptor	Homo sapiens	0-3
28870774-8	2018	In total, VDR sites with GABPA co-localization may control some 450 vitamin D target genes.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	10-13
25377645-2	2015	As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D.	Vitamin D	113-122	vitamin D receptor	Homo sapiens	39-42
28951226-3	2018	Active vitamin D downregulates macrophage JNK activation, suppressing oxidized LDL cholesterol uptake and foam cell formation and promoting an anti-inflammatory phenotype.	Vitamin D	7-16	mitogen-activated protein kinase 8	Mus musculus	42-45
26296372-1	2015	Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	0-27
28951226-9	2018	We have previously shown that peritoneal macrophages obtained from LDLR-/- mice fed vitamin D-deficient HFD diets have higher foam cell formation compared to those from mice on vitamin D-sufficient HFD.	Vitamin D	84-93	low density lipoprotein receptor	Mus musculus	67-71
26296372-1	2015	Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	29-34
26296372-2	2015	It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis.	Vitamin D	55-64	fibroblast growth factor 23	Homo sapiens	100-105
29287957-3	2018	VDR antagonists and partial agonists have been developed based on the secosteroid scaffold of vitamin D.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	0-3
26296372-2	2015	It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis.	Vitamin D	106-115	fibroblast growth factor 23	Homo sapiens	34-39
29018141-8	2018	The chromatin immunoprecipitation results suggested that C-Ret is directly regulated by vitamin D via VDR.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	102-105
26296372-2	2015	It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis.	Vitamin D	106-115	fibroblast growth factor 23	Homo sapiens	100-105
25234352-11	2015	The higher circulating VDBP concentrations and higher vitamin D catabolic rate among Caucasian Americans observed here appear to be consistent with lower bone mineral density and racial and ethnic differences in vitamin D-inducing cytokines.	Vitamin D	212-221	GC vitamin D binding protein	Homo sapiens	23-27
29233860-4	2018	Vitamin D receptor (VDR) expression is common to multiple immune cell types, and thus, pathway analysis of gene expression using data from multiple related models provides an inclusive perspective on the immunomodulatory impact of vitamin D.	Vitamin D	231-240	vitamin D receptor	Homo sapiens	0-18
29382742-7	2018	These findings uncover an important link between androgens and vitamin D homeostasis and suggest that therapeutic modulation of Pgr may be used to treat vitamin D deficiency and related disorders.	Vitamin D	63-72	progesterone receptor	Mus musculus	128-131
26045671-0	2015	Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis.	Vitamin D	57-66	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	19-26
29358755-2	2018	24-hydroxylase encoded by CYP24A1 is the enzyme that degrades the active vitamin D metabolite.	Vitamin D	73-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	26-33
26029210-0	2015	Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation.	Vitamin D	84-93	CD44 molecule (Indian blood group)	Homo sapiens	21-25
29032145-1	2018	Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	89-107
25712257-2	2015	The objectives were to (1) establish if increasing doses of vitamin D (VD) results in a proportionate dose-response in C-3 epimer; and (2) determine the biological response of bone to C-3 epimer treatment.	Vitamin D	60-69	complement C3	Rattus norvegicus	119-122
29315215-2	2018	We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women.	Vitamin D	78-87	7-dehydrocholesterol reductase	Homo sapiens	210-215
29315215-2	2018	We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women.	Vitamin D	186-195	7-dehydrocholesterol reductase	Homo sapiens	210-215
25616026-7	2015	Increased maternal dietary vitamin D was associated with significant increases in IL-10 release by AEC after stimulation with TNF-alpha/IL-1beta (P = 0.024) or HDM (P = 0.049).	Vitamin D	27-36	interleukin 10	Homo sapiens	82-87
30143987-4	2018	As VDR and the enzyme 1-alpha-hydroxylase are expressed in most immune cells, vitamin D modulates the phagocytic activity of macrophages and natural killer cells.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	3-6
30143987-6	2018	In contrast, vitamin D suppresses differentiation and maturation of antigen-presenting dendritic cells and B lymphocytes, and it inhibits proliferation of Th1 and Th17 cells.	Vitamin D	13-22	negative elongation factor complex member C/D	Homo sapiens	155-158
26066475-1	2015	PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	19-46
30269113-3	2018	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3[1,25(OH)2D3], is a potent VDR ligand, and contributes to the maintenance of calcium homeostasis by enhancing intestinal calcium absorption, renal calcium reabsorption and bone resorption.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	86-89
30269115-4	2018	The main physiological function of FGF23 is to suppress phosphate reabsorption and active vitamin D production in the proximal tubule of the kidney, thereby lowering serum concentration of inorganic phosphate.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	35-40
26066475-1	2015	PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	48-53
30269119-2	2018	Animal studies using mice model such as vitamin D deficiency and global and conditional VDR knock out(KO)mice have disclosed that the physiological role of vitamin D strongly depends on the calcium balance.	Vitamin D	156-165	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	88-91
25957423-0	2015	Role of vitamin D in improvement in changes of podocyte P-cadherin/beta-catenin complex induced by diabetic conditions.	Vitamin D	8-17	catenin (cadherin associated protein), beta 1	Mus musculus	67-79
25957423-1	2015	INTRODUCTION: This study aimed to investigate the effect of vitamin D on the pathologic changes of podocyte beta-catenin and P-cadherin and podocyte permeability induced by diabetic conditions.	Vitamin D	60-69	catenin (cadherin associated protein), beta 1	Mus musculus	108-120
25912039-3	2015	The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-gamma, IL-17 and induction of IL-4.	Vitamin D	23-32	interleukin 17A	Mus musculus	120-125
29110598-11	2018	Sirtuin1 is elevated by naturally occurring anti-oxidant and anti-inflammatory compounds such as resveratrol, trans-delta-viniferin, vitamin D and more.	Vitamin D	133-142	sirtuin 1	Homo sapiens	0-8
25912039-9	2015	Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-gamma, while inducing IL-4 and IL-10, would be beneficial.	Vitamin D	46-55	interleukin 17A	Mus musculus	138-143
25874538-11	2015	Vitamin D supplemented groups and rats with PTH-tissue ablation showed modestly increased parenchymal abundance of glial-fibrillary acidic protein (GFAP), a marker of astroglial activation.	Vitamin D	0-9	glial fibrillary acidic protein	Rattus norvegicus	115-146
29371756-4	2018	In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group.	Vitamin D	30-39	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	123-130
29371756-7	2018	Our results suggest that age-related alterations in renal alpha-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.	Vitamin D	138-147	klotho	Mus musculus	64-70
25874538-11	2015	Vitamin D supplemented groups and rats with PTH-tissue ablation showed modestly increased parenchymal abundance of glial-fibrillary acidic protein (GFAP), a marker of astroglial activation.	Vitamin D	0-9	glial fibrillary acidic protein	Rattus norvegicus	148-152
25849303-1	2015	Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	66-84
30938651-1	2018	Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations at the level of the vitamin D receptor ( VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	114-132
30938651-1	2018	Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations at the level of the vitamin D receptor ( VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
30938651-6	2018	Treatment success depended on the position of the mutation within the VDR protein: children with the p.R391S mutation had a favorable outcome but maintained alopecia totalis, while 1 child with the p.H397P mutation and normal hair had no response to very high doses of vitamin D.	Vitamin D	269-278	vitamin D receptor	Homo sapiens	70-73
30212831-10	2018	In addition, plasma active vitamin D levels were significantly increased in Akp3-/- mice compared with wild-type animals.	Vitamin D	27-36	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	76-80
27966076-7	2018	However, vitamin D metabolism encoding genes of CYP27B1 and CYP24A1 and predicting MS risk gene of HLA-DRB1*15:01 define its fate as well.	Vitamin D	9-18	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-67
30300431-9	2018	Vitamin D has an effect on bone remodeling through its receptor and its polymorphisms: Apa1, Bsm1, Taq1, Fok1 and Cdx2.	Vitamin D	0-9	caudal type homeobox 2	Homo sapiens	114-118
29021285-5	2017	Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy.	Vitamin D	266-275	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	113-120
29021285-5	2017	Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy.	Vitamin D	304-313	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	113-120
29021285-5	2017	Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy.	Vitamin D	304-313	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	113-120
29021285-5	2017	Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy.	Vitamin D	304-313	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	113-120
29278636-2	2017	The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	56-75
29278636-2	2017	The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	77-80
29278636-2	2017	The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	77-80
28492801-7	2017	Calcitriol highly induced its target gene, CYP24A1, indicating that the genomic vitamin D pathway is active in tumorgrafts.	Vitamin D	80-89	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	43-50
28407346-1	2017	Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	76-79
28407346-1	2017	Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	76-79
28407346-1	2017	Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	245-248
28954197-0	2017	Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-109
29038561-8	2017	DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele.	Vitamin D	92-101	7-dehydrocholesterol reductase	Homo sapiens	0-5
29062180-11	2017	VDR gene polymorphism was found to be associated with MFI cases as compared to controls and the serum level of vitamin D was also decreased in MFI cases than in controls (p value &lt; 0.05).	Vitamin D	111-120	vitamin D receptor	Homo sapiens	0-3
27693422-0	2017	Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORalpha and RORgamma.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	93-96
27693422-0	2017	Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORalpha and RORgamma.	Vitamin D	35-44	RAR related orphan receptor A	Homo sapiens	121-129
27693422-1	2017	The classical pathway of vitamin D activation follows the sequence D3 25(OH)D3 1,25(OH)2D3 with the final product acting on the receptor for vitamin D (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	152-155
27693422-1	2017	The classical pathway of vitamin D activation follows the sequence D3 25(OH)D3 1,25(OH)2D3 with the final product acting on the receptor for vitamin D (VDR).	Vitamin D	141-150	vitamin D receptor	Homo sapiens	152-155
27693422-13	2017	We suggest that the identification of large number of endogenously produced alternative hydroxy-metabolites of D3 that are biologically active, and of possible alternative receptors, may offer an explanation for the pleiotropic and diverse activities of vitamin D, previously assigned solely to 1,25(OH)2D3 and VDR.	Vitamin D	254-263	vitamin D receptor	Homo sapiens	311-314
27693423-2	2017	In recent years the spectrum of vitamin D target organs has expanded and a reproductive role is supported by the presence of the vitamin D receptor (VDR) and the vitamin D metabolizing enzymes in the gonads, reproductive tract, and human spermatozoa.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	129-147
27693423-2	2017	In recent years the spectrum of vitamin D target organs has expanded and a reproductive role is supported by the presence of the vitamin D receptor (VDR) and the vitamin D metabolizing enzymes in the gonads, reproductive tract, and human spermatozoa.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	149-152
27693423-2	2017	In recent years the spectrum of vitamin D target organs has expanded and a reproductive role is supported by the presence of the vitamin D receptor (VDR) and the vitamin D metabolizing enzymes in the gonads, reproductive tract, and human spermatozoa.	Vitamin D	129-138	vitamin D receptor	Homo sapiens	149-152
27693423-3	2017	Interestingly, expression levels of VDR and the vitamin D inactivating enzyme CYP24A1 in human spermatozoa serve as positive predictive markers of semen quality and are higher expressed in spermatozoa from normal than infertile men.	Vitamin D	48-57	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	78-85
27693423-8	2017	The VDR is ubiquitously expressed and activated vitamin D is a regulator of insulin, aromatase, and osteocalcin.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	4-7
29096595-1	2017	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone.	Vitamin D	174-183	fibroblast growth factor 23	Homo sapiens	0-27
29096595-1	2017	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone.	Vitamin D	174-183	fibroblast growth factor 23	Homo sapiens	29-34
29870623-1	2017	Background and purpose: This study aimed to assess the correlation between vitamin D deficiency and electrophysiological findings and pain level in patients with symptoms of carpal tunnel syndrome (CTS).	Vitamin D	75-84	transthyretin	Homo sapiens	198-201
29870623-5	2017	Results: Although the rate of CTS in the patients with a low vitamin D level was found to be high, no statistically significant correlation was observed between low vitamin D level and the frequency and severity of CTS.	Vitamin D	61-70	transthyretin	Homo sapiens	30-33
29870623-6	2017	Additionally, the pain and functional loss ratio induced by CTS was found to be higher in the group with a lower vitamin D level than in the group with normal levels.	Vitamin D	113-122	transthyretin	Homo sapiens	60-63
29870623-7	2017	Conclusion: Low vitamin D levels may increase the severity of CTS symptoms.	Vitamin D	16-25	transthyretin	Homo sapiens	62-65
29870623-8	2017	Treatment of vitamin D deficiency in patients with CTS can play a role in reducing pain and disability.	Vitamin D	13-22	transthyretin	Homo sapiens	51-54
28922414-2	2017	Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers.	Vitamin D	0-9	carbonyl reductase 1	Homo sapiens	114-151
28579119-5	2017	The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes.	Vitamin D	252-261	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	143-150
28579119-5	2017	The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes.	Vitamin D	252-261	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	143-150
28579120-4	2017	Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	36-54
28579120-4	2017	Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	56-59
28579120-6	2017	The transcriptional activity of vitamin D occurs via the nuclear VDR.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	65-68
28579120-8	2017	The VDR is present in the developing and adult brain where it mediates the effects of vitamin D on brain development and function.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	4-7
28602863-5	2017	Vitamin D receptor number decreases with aging in several organs involved in calcium metabolism and 1alpha-hydroxylase activity decreases mainly due to a decrease in renal function reducing vitamin D activation.	Vitamin D	190-199	vitamin D receptor	Homo sapiens	0-18
28902929-9	2017	These results indicated that vitamin D concentrations in the decidua are associated with inflammatory cytokine production, suggesting that vitamin D and VDR may play a role in the etiology of RSA.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	153-156
28768705-2	2017	In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1.	Vitamin D	8-17	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	217-224
25849303-1	2015	Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	86-89
28712921-1	2017	The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH)2D3).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	45-48
28712921-4	2017	Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios.	Vitamin D	210-219	vitamin D receptor	Homo sapiens	94-97
28712921-4	2017	Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios.	Vitamin D	210-219	vitamin D receptor	Homo sapiens	163-166
25849303-3	2015	VDR is a critical component of the vitamin D pathway and different common single nucleotide polymorphisms have been identified.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	0-3
28712921-7	2017	The number of persistent and transient VDR sites was found to be the main discriminator for sorting these TADs into five classes carrying vitamin D target genes involved in distinct biological processes.	Vitamin D	138-147	vitamin D receptor	Homo sapiens	39-42
28712921-8	2017	In conclusion, specific regulation of biological processes by vitamin D depends on differences in time-dependent VDR binding.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	113-116
25849303-8	2015	Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested.	Vitamin D	0-9	caudal type homeobox 2	Homo sapiens	71-75
28710799-4	2017	Vitamin D plays an important role in glucose homeostasis and insulin secretion through transcriptional mechanisms mediated by its receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	140-143
28710799-7	2017	The aim of this study was to evaluate the effect of hyperglycemia on VDR OGlcNAcylation and its effects on vitamin D-mediated transcription.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	69-72
25849303-8	2015	Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	76-79
25849303-10	2015	Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative).	Vitamin D	87-96	caudal type homeobox 2	Homo sapiens	46-50
28492133-4	2017	However, because of vagaries in the measurement of VDBP in particular and the assumption of a constant affinity of VDBP for the vitamin D metabolites (which has been shown to be problematic), calculated values have proved suspect.	Vitamin D	128-137	GC vitamin D binding protein	Homo sapiens	115-119
25849303-10	2015	Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative).	Vitamin D	87-96	vitamin D receptor	Homo sapiens	51-54
25849303-11	2015	These results suggest that Cdx2 polymorphism may be a potential biomarker for vitamin D treatment in breast cancer, independently of the VDR receptor expression.	Vitamin D	78-87	caudal type homeobox 2	Homo sapiens	27-31
25695404-3	2015	The human KL gene encodes the alpha-Klotho protein, which is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D.	Vitamin D	144-153	klotho	Homo sapiens	10-12
28578001-1	2017	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], acts as a ligand for the vitamin D receptor (VDR), and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity and cardiovascular function.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	100-118
28578001-1	2017	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], acts as a ligand for the vitamin D receptor (VDR), and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity and cardiovascular function.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	120-123
28578001-4	2017	Our prior study has demonstrated that 1,25(OH)2D3 induces TRPV6 mRNA expression at lower concentrations than for induction of CYP24A1, a VDR target gene involved in vitamin D inactivation, in intestinal SW480 cells, suggesting an additional mechanism for vitamin D signaling on TRPV6 induction.	Vitamin D	165-174	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	126-133
28578001-4	2017	Our prior study has demonstrated that 1,25(OH)2D3 induces TRPV6 mRNA expression at lower concentrations than for induction of CYP24A1, a VDR target gene involved in vitamin D inactivation, in intestinal SW480 cells, suggesting an additional mechanism for vitamin D signaling on TRPV6 induction.	Vitamin D	165-174	vitamin D receptor	Homo sapiens	137-140
25695404-3	2015	The human KL gene encodes the alpha-Klotho protein, which is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D.	Vitamin D	144-153	klotho	Homo sapiens	36-42
25637936-6	2015	DHCR7 is important for both cholesterol and vitamin D synthesis, and we have identified a novel layer of regulation, whereby its activity is controlled by DHCR24.	Vitamin D	44-53	7-dehydrocholesterol reductase	Homo sapiens	0-5
28636886-1	2017	The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	85-103
28636886-1	2017	The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	105-108
28636886-1	2017	The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	145-148
28636886-1	2017	The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes.	Vitamin D	27-36	retinoid X receptor alpha	Homo sapiens	156-175
28636886-1	2017	The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes.	Vitamin D	27-36	retinoid X receptor alpha	Homo sapiens	177-180
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	cubilin	Homo sapiens	112-116
28732681-1	2017	Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described.	Vitamin D	104-113	GC vitamin D binding protein	Homo sapiens	0-25
28732681-1	2017	Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described.	Vitamin D	195-204	GC vitamin D binding protein	Homo sapiens	0-25
25784096-15	2015	CONCLUSION: Vitamin D may modulate the expression of IL-27 and IL-33 in the spinal cord of EAE mice and also ameliorate the clinical symptoms of the disease.	Vitamin D	12-21	interleukin 27	Mus musculus	53-58
28070798-5	2017	Moreover, the expression of the vitamin D receptor (VDR) in these cells suggests a local action of vitamin D in the immune response.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	52-55
25784096-15	2015	CONCLUSION: Vitamin D may modulate the expression of IL-27 and IL-33 in the spinal cord of EAE mice and also ameliorate the clinical symptoms of the disease.	Vitamin D	12-21	interleukin 33	Mus musculus	63-68
25457999-0	2015	Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33.	Vitamin D	0-9	ST2	Homo sapiens	41-44
28814738-2	2017	Using a virtual screening platform to search novel chemical probes that activate the vitamin D signaling, we report discovery of novel non-steroidal small-molecule compounds that activate the vitamin D receptor (VDR), but are devoid of hypercalcemia.	Vitamin D	85-94	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	192-210
25201000-0	2015	Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	23-30
28814738-2	2017	Using a virtual screening platform to search novel chemical probes that activate the vitamin D signaling, we report discovery of novel non-steroidal small-molecule compounds that activate the vitamin D receptor (VDR), but are devoid of hypercalcemia.	Vitamin D	85-94	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	212-215
28814738-7	2017	Furthermore, VDR 4-1 therapy significantly suppressed cardiac hypertrophy and progression to heart failure in both vitamin D deficient and normal mice without inducing significant hypercalcemia.	Vitamin D	115-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	13-16
27396287-12	2017	Similarly, low levels of dietary vitamin D were associated with increased MNBN frequency in cord blood [middle tertile IRR = 1.08 (0.78, 1.47), lower tertile IRR = 1.51 (1.06, 2.14)].	Vitamin D	33-42	insulin receptor related receptor	Homo sapiens	119-122
27396287-12	2017	Similarly, low levels of dietary vitamin D were associated with increased MNBN frequency in cord blood [middle tertile IRR = 1.08 (0.78, 1.47), lower tertile IRR = 1.51 (1.06, 2.14)].	Vitamin D	33-42	insulin receptor related receptor	Homo sapiens	158-161
28470390-0	2017	Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.	Vitamin D	102-111	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	23-30
28575224-12	2017	Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity.	Vitamin D	102-111	7-dehydrocholesterol reductase	Homo sapiens	34-39
28575224-12	2017	Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity.	Vitamin D	102-111	GC vitamin D binding protein	Homo sapiens	343-368
25201000-1	2015	OBJECTIVE: The aims of the present study were to examine gene and protein expression of the vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzyme in human papillary thyroid cancer (PTC), furthermore, to investigate the association between CYP24A1 expression and numerous clinical, histological parameters and somatic oncogene mutation status of thyroid tumor tissues.	Vitamin D	92-101	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	130-137
25201000-1	2015	OBJECTIVE: The aims of the present study were to examine gene and protein expression of the vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzyme in human papillary thyroid cancer (PTC), furthermore, to investigate the association between CYP24A1 expression and numerous clinical, histological parameters and somatic oncogene mutation status of thyroid tumor tissues.	Vitamin D	92-101	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	288-295
25499229-2	2015	Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR).	Vitamin D	23-32	vitamin D receptor	Homo sapiens	65-83
28256004-1	2017	BACKGROUND AND OBJECTIVE: Vitamin D-binding protein (DBP) is a highly expressed plasma protein with many important functions, including transport of vitamin D metabolites, sequestration of actin, control of bone metabolism and modulation of immune and inflammatory responses.	Vitamin D	149-158	GC vitamin D binding protein	Homo sapiens	26-51
25499229-2	2015	Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR).	Vitamin D	23-32	vitamin D receptor	Homo sapiens	85-88
25499229-4	2015	The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	39-42
25662556-10	2015	Apoptosis induction of VDR+ cells in oral precancerous lesions and OSCC by natural vitamin D or synthetic vitamin D compounds could be useful for chemoprevention.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	23-26
28786260-0	2017	Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit?	Vitamin D	0-9	vitamin D receptor	Homo sapiens	38-56
28786260-0	2017	Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit?	Vitamin D	0-9	vitamin D receptor	Homo sapiens	58-61
28670298-5	2017	Vitamin D treatment was also accompanied by 100-fold to 700-fold increases in vitamin D receptor expression during the treatment period (P &lt; 0.001).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	78-96
25662556-10	2015	Apoptosis induction of VDR+ cells in oral precancerous lesions and OSCC by natural vitamin D or synthetic vitamin D compounds could be useful for chemoprevention.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	23-26
25294851-0	2015	The induction of C/EBPbeta contributes to vitamin D inhibition of ADAM17 expression and parathyroid hyperplasia in kidney disease.	Vitamin D	42-51	ADAM metallopeptidase domain 17	Homo sapiens	66-72
25730037-1	2015	The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	51-54
28465245-8	2017	High levels of VDR in human gastric cancer tissues and cancer cell lines implicated that vitamin D could display more potent pharmacological action against malignant cells.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	15-18
28617856-16	2017	CONCLUSION: VDR BsmI polymorphism was significantly associated with vitamin D deficiency and insulin resistance, but not with obesity in this population.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	12-15
25620699-1	2015	The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	177-195
28524342-8	2017	On the contrary, serum DHEAS was significantly affected by vitamin D (MD -32.24 mug/dL, 95% CI -32.24 to -14.01) an effect which was mainly affected by the vitamin D vs placebo comparison.	Vitamin D	59-68	sulfotransferase family 2A member 1	Homo sapiens	23-28
28524342-8	2017	On the contrary, serum DHEAS was significantly affected by vitamin D (MD -32.24 mug/dL, 95% CI -32.24 to -14.01) an effect which was mainly affected by the vitamin D vs placebo comparison.	Vitamin D	156-165	sulfotransferase family 2A member 1	Homo sapiens	23-28
25620699-1	2015	The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	197-200
27987058-7	2017	Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2).	Vitamin D	64-73	mannose receptor, C type 1	Mus musculus	239-244
25495694-5	2015	Our results indicate that repression by calcitriol occurs at the transcriptional level and involves a functional negative vitamin D response element (nVDRE) E-box type in the hEAG1 promoter.	Vitamin D	122-131	potassium voltage-gated channel subfamily H member 1	Homo sapiens	175-180
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	275-282
28243735-2	2017	Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	142-160
28243735-2	2017	Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	162-165
25563643-1	2015	BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism.	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	24-51
28243735-2	2017	Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	162-165
28332200-4	2017	The binding of vitamin D to dendritic cells (DCs) through vitamin D receptors inhibits the action of IL-12 on DCs, resulting in the downregulation of Th1 and Th17.	Vitamin D	15-24	negative elongation factor complex member C/D	Homo sapiens	150-153
25563643-1	2015	BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism.	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	53-58
25630909-5	2015	Furthermore, the mRNAs of natriuretic peptides, neutrophil gelatinase-associated lipocalin, hREN, and rRen were increased by vitamin D depletion.	Vitamin D	125-134	lipocalin 2	Homo sapiens	48-90
27715403-5	2017	Calcitriol, the active form of vitamin D, has been shown to decrease STAT1 and STAT3 phosphorylation in cancer cell lines and autoimmune disease mouse models.	Vitamin D	31-40	signal transducer and activator of transcription 1	Mus musculus	69-74
26319903-3	2015	VDR is a crucial mediator for the cellular effects of vitamin D and conflicting data have been reported for most malignancies.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	0-3
28464004-12	2017	In fully adjusted models, vitamin D associations with abnormal biomarker levels persisted for IL-6 levels and CX3CR1+ and CCR2+ phenotypes.	Vitamin D	26-35	C-X3-C motif chemokine receptor 1	Homo sapiens	110-116
25446019-0	2015	Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations.	Vitamin D	97-106	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-121
28431765-4	2017	The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	86-104
28431765-4	2017	The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	106-109
28095044-2	2017	Vitamin D3 undergoes conversion through a multitude of enzymatic reactions described within the paper, and vitamin D levels are dependent on many factors including the vitamin D binding protein (DBP).	Vitamin D	107-116	GC vitamin D binding protein	Homo sapiens	168-193
25446019-1	2015	Loss-of-function mutations of CYP24A1, the enzyme that converts the major circulating and active forms of vitamin D to inactive metabolites, recently have been implicated in idiopathic infantile hypercalcemia.	Vitamin D	106-115	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
25279449-3	2015	Vitamin D seems to influence antiviral response in chronic hepatitis C and its pathway is controlled by polymorphic genes such as CYP27B1, CYP24A1 and VDR.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	139-146
25773805-1	2015	Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	82-85
28177523-2	2017	The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	147-165
28177523-2	2017	The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	167-170
28177523-2	2017	The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	184-187
25961000-9	2015	The above results demonstrate that active vitamin D promoted M1 phenotype switching to M2 via the VDR-PPARgamma pathway.	Vitamin D	42-51	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	98-101
25685788-2	2015	Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	42-45
25530521-2	2015	Fibroblast growth factor 23 (FGF23) is a hormone mainly produced by osteocytes and regulates phosphate and vitamin D metabolism by binding to Klotho-FGF receptor complex.	Vitamin D	107-116	fibroblast growth factor 23	Homo sapiens	0-27
25530521-2	2015	Fibroblast growth factor 23 (FGF23) is a hormone mainly produced by osteocytes and regulates phosphate and vitamin D metabolism by binding to Klotho-FGF receptor complex.	Vitamin D	107-116	fibroblast growth factor 23	Homo sapiens	29-34
25530521-3	2015	Most diseases previously called vitamin D-resistant rickets/osteomalacia or familial hypophosphatemic rickets/osteomalacia have been shown to be caused by excess actions of FGF23.	Vitamin D	32-41	fibroblast growth factor 23	Homo sapiens	173-178
25791938-10	2015	CONCLUSIONS: This study showed vitamin D supplementation to be an effective treatment in reducing AD severity in children through normalization of the Th1 and Th2 interleukin serum pattern.	Vitamin D	31-40	negative elongation factor complex member C/D	Homo sapiens	151-154
26451144-2	2015	The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) and common inflammatory markers after administration of paricalcitol, a vitamin D analog, in vivo and in vitro.	Vitamin D	65-74	lipocalin 2	Homo sapiens	139-181
26451144-2	2015	The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) and common inflammatory markers after administration of paricalcitol, a vitamin D analog, in vivo and in vitro.	Vitamin D	65-74	lipocalin 2	Homo sapiens	183-187
25984539-0	2015	Vitamin D deficiency contributes to the reduction and impaired function of naive CD45RA+ regulatory T cell in chronic heart failure.	Vitamin D	0-9	protein tyrosine phosphatase receptor type C	Homo sapiens	81-85
26304832-2	2015	Idiopathic infantile hypercalcemia is caused by mutations of the CYP24A1 gene, which regulates vitamin D activity.	Vitamin D	95-104	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	65-72
25637898-3	2015	It is caused by a tumor that produces fibroblast growth factor 23, a hormone that decreases the tubular phosphate reabsorption and impairs renal hydroxylation of vitamin D.	Vitamin D	162-171	fibroblast growth factor 23	Homo sapiens	38-65
25985946-4	2015	Vitamin D signals through the vitamin D receptor (VDR), a specific zinc-finger nuclear receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	30-48
25985946-4	2015	Vitamin D signals through the vitamin D receptor (VDR), a specific zinc-finger nuclear receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	50-53
25985946-5	2015	The functions of vitamin D are characterized as genomic, mediated through the VDR transcriptional effects inside the cell nucleus, and non-genomic, when the VDR induces rapid signaling, situated on the cell membrane and/or cytoplasm.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	78-81
25985946-5	2015	The functions of vitamin D are characterized as genomic, mediated through the VDR transcriptional effects inside the cell nucleus, and non-genomic, when the VDR induces rapid signaling, situated on the cell membrane and/or cytoplasm.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	157-160
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	187-194
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	276-279
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	281-284
25292315-0	2015	The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats.	Vitamin D	27-36	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	18-23
26241700-7	2015	Overall, CYP24A1 polymorphisms may influence the development of advanced lesions, and modify the effect of vitamin D metabolites on adenoma recurrence.	Vitamin D	107-116	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	9-16
25546457-9	2014	Accordingly, treatment of HaCaT cells with vitamin D downregulated both subunits, suggesting that VDR may inhibit the respiratory chain and redirect TCA intermediates toward biosynthesis, thus contributing to the metabolic switch that is typical of cancer cells.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	98-101
25541958-1	2014	BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	90-108
25541958-1	2014	BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	110-113
25541958-1	2014	BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis.	Vitamin D	62-71	GC vitamin D binding protein	Homo sapiens	119-144
25541958-1	2014	BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	110-113
25463121-11	2014	Change in 25(OH)D and IL-17 levels were independent predictors of the change in FMD measurements following vitamin D replacement.	Vitamin D	107-116	interleukin 17A	Homo sapiens	22-27
25137505-1	2014	PURPOSE OF REVIEW: To highlight recently published data about the vitamin D status of athletes, and effect of vitamin D supplementation on muscle strength and performance in the athletic population.The vitamin D receptor exists in skeletal muscle, and muscle weakness has been reported in individuals who are severely deficient [25(OH)D &lt;25 nmol/l].	Vitamin D	66-75	vitamin D receptor	Homo sapiens	202-220
25137505-1	2014	PURPOSE OF REVIEW: To highlight recently published data about the vitamin D status of athletes, and effect of vitamin D supplementation on muscle strength and performance in the athletic population.The vitamin D receptor exists in skeletal muscle, and muscle weakness has been reported in individuals who are severely deficient [25(OH)D &lt;25 nmol/l].	Vitamin D	110-119	vitamin D receptor	Homo sapiens	202-220
24668555-4	2014	Vitamin D inhibits IFN-gamma and IL-17 production while inducing regulatory T cells.	Vitamin D	0-9	interleukin 17A	Homo sapiens	33-38
25059118-2	2014	Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	73-91
25059118-2	2014	Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	93-96
25353337-10	2014	VDR ApaI aa genotype was positively associated with well-controlled asthma according to GINA and C-ACT questionnaire and negatively associated with decreased limitation in daily activities in asthmatic children, further supporting the importance of Vitamin D pathway in asthma.	Vitamin D	249-258	vitamin D receptor	Homo sapiens	0-3
25087094-5	2014	When vitamin D was applied at a concentration of 1 x 10(-7) and 1 x 10(-6) mol/L on A549, PC9, SPC-A1, and H1650 cells for 72 h, no inhibition occurred on cell proliferation.	Vitamin D	5-14	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	95-101
24184871-8	2014	The absence of SR-A1 prevented the increased macrophage adhesion and migration induced by vitamin D deficiency.	Vitamin D	90-99	steroid receptor RNA activator 1	Homo sapiens	15-20
24239508-1	2014	The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), suppresses the proliferation while promoting the differentiation of keratinocytes through the vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	170-188
24239508-1	2014	The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), suppresses the proliferation while promoting the differentiation of keratinocytes through the vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	190-193
24239508-11	2014	These genes possess vitamin D response elements (VDRE) adjacent to TCF/beta-catenin response elements and are regulated by both VDR and beta-catenin signaling.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	49-52
25148392-4	2014	Docking experiments on the inhibitors in the CYP24A1 enzyme active site suggest the compounds reach the active site through the vitamin D access tunnel and are exposed to multiple hydrophobic residues.	Vitamin D	128-137	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	45-52
25230725-0	2014	Vitamin D-binding protein controls T cell responses to vitamin D.	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	0-25
25356106-0	2014	High GPX1 expression promotes esophageal squamous cell carcinoma invasion, migration, proliferation and cisplatin-resistance but can be reduced by vitamin D.	Vitamin D	147-156	glutathione peroxidase 1	Homo sapiens	5-9
25228524-3	2014	It is claimed that vitamin D inhibits immunological reactions with Th1 and Th17 lymphocytes.	Vitamin D	19-28	negative elongation factor complex member C/D	Homo sapiens	67-70
25228524-6	2014	It was observed that vitamin D had a beneficial influence on diseases connected with excessive activation of Th1 lymphocytes, such as multiple sclerosis, rheumatoid arthritis, non-specific enteritis, diabetes type 1 or psoriasis.	Vitamin D	21-30	negative elongation factor complex member C/D	Homo sapiens	109-112
24926821-3	2014	The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	113-116
24926821-3	2014	The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form.	Vitamin D	38-47	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	195-202
25194407-2	2014	The aim of present study was to evaluate the relationship between vitamin D receptor (VDR) gene FokI and ApaI polymorphisms with serum levels of fetuin-A, vitamin D, and intact PTH in hemodialysis patients.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	86-89
25194407-10	2014	CONCLUSIONS: Our study shows that increased serum level of PTH and decreased fetuin-A and vitamin D levels may increase susceptibility of atherosclerosis in patients with hemodialysis through VDR gene FokI and ApaI polymorphisms.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	192-195
25198236-0	2014	Changes of fibroblast growth factor 23 (FGF23) levels following calcitriol treatment in a vitamin D deficient patient.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	11-38
25198236-0	2014	Changes of fibroblast growth factor 23 (FGF23) levels following calcitriol treatment in a vitamin D deficient patient.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	40-45
24742873-10	2014	Stratification according to study characteristics showed that publication year, age, gender, estimated vitamin D levels and latitude moderated significantly association between VDR polymorphisms and T1D disease.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	177-180
24947687-8	2014	CONCLUSIONS: The determinants of the serum FGF-23 level in MHD patients without residual renal function were age, serum phosphate, Ca, iPTH levels, the active vitamin D dose and the GNRI.	Vitamin D	159-168	fibroblast growth factor 23	Homo sapiens	43-49
24325596-1	2014	BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	77-95
24325596-1	2014	BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	97-100
24325596-1	2014	BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	97-100
25147936-2	2014	We identified a variant (R21L) in exon 2 of the GC globulin gene, which is involved in the transportation of vitamin D metabolites and acts as a chemotaxic factor; this variant was co-segregated within the family.	Vitamin D	109-118	GC vitamin D binding protein	Homo sapiens	48-59
25148115-10	2014	SUMMARY: Patients with preeclampsia displayed lower vitamin D serum levels in response to seasonal changes.The regulation of placental CYP24A1, but not of the VDR or CYP27B1 might be altered in preeclampsia.	Vitamin D	52-61	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	135-142
25285313-6	2014	The vitamin D response element was significantly enriched in this system, indicating a direct regulation of this gene interaction network through the vitamin D receptor.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	150-168
31084485-3	2017	The aim of this study is to explore the associations between vitamin D (FOKI) receptor gene polymorphism (VDR) and vitamin D deficiency (VDD) and chronic musculoskeletal pain.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	106-109
24854954-8	2014	In primary human peripheral blood mononuclear cells from 71 prediabetic subjects of a vitamin D(3) intervention study (VitDmet) CD97, LRRC8A, SLC37A2 and NRIP1 can be used as transcriptomic biomarkers for classifying human individuals for their possible benefit from vitamin D(3) supplementation.	Vitamin D	86-95	solute carrier family 37 member 2	Homo sapiens	142-149
25237378-3	2014	The aim of the current study therefore is to investigate if vitamin D modulates the expression and activation of MMP-2 and MMP-9 in human lung fibroblasts (HFL-1) cells.	Vitamin D	60-69	matrix metallopeptidase 9	Homo sapiens	123-128
28324001-0	2017	CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations.	Vitamin D	57-66	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	97-104
28324001-1	2017	Context: The P450 enzyme CYP24A1 is the principal inactivator of vitamin D metabolites.	Vitamin D	65-74	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	25-32
24920722-1	2014	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone that promotes urinary phosphate excretion and regulates vitamin D metabolism.	Vitamin D	118-127	fibroblast growth factor 23	Homo sapiens	12-39
28186657-0	2017	Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium, and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease.	Vitamin D	15-24	parathyroid hormone	Canis lupus familiaris	42-61
24920722-1	2014	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone that promotes urinary phosphate excretion and regulates vitamin D metabolism.	Vitamin D	118-127	fibroblast growth factor 23	Homo sapiens	41-47
28109821-1	2017	OBJECTIVE: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults.	Vitamin D	31-40	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-96
28109821-1	2017	OBJECTIVE: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults.	Vitamin D	117-126	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-96
24924628-5	2014	1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells.	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	170-188
28362172-5	2017	Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined.	Vitamin D	19-28	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	54-61
24924628-5	2014	1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells.	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	190-193
24768180-3	2014	To assess for association between polymorphisms of vitamin-D pathway genes CYP27B1, vitamin-D binding protein (VDBP) and VDR with HIV-1 infection, disease progression to acquired immunodeficiency syndrome (AIDS) was analysed according to CDC93 criteria in a cohort of 185 HIV-1 seroprevalent patients belonging to the injection drug users.	Vitamin D	51-60	GC vitamin D binding protein	Homo sapiens	111-115
28290237-15	2017	Lower vitamin D status has been found in HT patients than in controls, and inverse relationships of serum vitamin D with TPO/Tg antibodies have been reported.	Vitamin D	106-115	thyroid peroxidase	Homo sapiens	121-124
28290237-16	2017	However, other data and the lack of trial evidence suggest that low vitamin D status is more likely the result of autoimmune disease processes that include vitamin D receptor dysfunction.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	156-174
24768180-3	2014	To assess for association between polymorphisms of vitamin-D pathway genes CYP27B1, vitamin-D binding protein (VDBP) and VDR with HIV-1 infection, disease progression to acquired immunodeficiency syndrome (AIDS) was analysed according to CDC93 criteria in a cohort of 185 HIV-1 seroprevalent patients belonging to the injection drug users.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	121-124
24976054-3	2014	alpha-kl (- / -) mice display multiple aging related phenotypes including atherosclerosis, cardiovascular/soft tissue calcifications, pulmonary emphysema, osteopenia, and senile atrophy of skin ; such age-related organ pathologies are associated with biochemical changes in blood, including severe hyperphosphatemia, elevated serum FGF23 and1,25 (OH) 2 Vitamin D levels.	Vitamin D	353-362	klotho	Mus musculus	0-8
28460457-2	2017	Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	66-84
28460457-2	2017	Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	86-89
24893882-0	2014	Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway.	Vitamin D	48-57	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	26-33
28460457-10	2017	This new mechanism of VDR action in breast cancer cells contrasts the known anti-proliferative nuclear actions of the VDR-vitamin D ligand complex.	Vitamin D	122-131	vitamin D receptor	Homo sapiens	22-25
28460457-10	2017	This new mechanism of VDR action in breast cancer cells contrasts the known anti-proliferative nuclear actions of the VDR-vitamin D ligand complex.	Vitamin D	122-131	vitamin D receptor	Homo sapiens	118-121
28415985-5	2017	Patients were genotyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020, rs2282679), CYP2R1 (rs2060793, rs12794714), CYP27B1 (rs10877012), and DHCR7 (rs12785878).	Vitamin D	51-60	7-dehydrocholesterol reductase	Homo sapiens	188-193
24893882-1	2014	CYP24A1 is the multicatalytic cytochrome P450 responsible for the catabolism of vitamin D via the C23- and C24-oxidation pathways.	Vitamin D	80-89	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
24470103-0	2014	Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice.	Vitamin D	82-91	fibroblast growth factor 23	Mus musculus	9-36
28242615-1	2017	CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D.	Vitamin D	45-54	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
28242615-1	2017	CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D.	Vitamin D	178-187	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
24470103-12	2014	These results suggest that increased levels of circulating FGF23 in pathological conditions such as Hyp mice exerts direct effects on the placenta and affects fetal vitamin D metabolism via the regulation of Cyp24a1 expression.	Vitamin D	165-174	fibroblast growth factor 23	Mus musculus	59-64
28284354-1	2017	Vitamin D binding protein (DBP) gene encodes for Gc, an alpha2 globulin that transports vitamin D metabolites in serum.	Vitamin D	88-97	GC vitamin D binding protein	Homo sapiens	0-25
24823836-4	2014	Lower level of vitamin D resulted in reduced vitamin D receptor and increased expression of pro-inflammatory genes in the colon at 3 months, lower numbers of colonic Bacteroides/Prevotella at postnatal day 21 and higher serum LPS concentration at adulthood.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	45-63
28443031-1	2017	The vitamin D receptor (VDR) knockout (KO) mouse is a common model to unravel novel metabolic functions of vitamin D.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
24922628-1	2014	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	12-39
28376103-0	2017	Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: A randomised double-blinded, placebo-control trial.	Vitamin D	14-23	C-X-C motif chemokine ligand 10	Homo sapiens	62-67
28376103-5	2017	Vitamin D suppressed expression of IP-10 from monocytes in vitro.	Vitamin D	0-9	C-X-C motif chemokine ligand 10	Homo sapiens	35-40
28376103-7	2017	We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV.	Vitamin D	35-44	negative elongation factor complex member C/D	Homo sapiens	156-159
24922628-1	2014	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	41-47
28376103-7	2017	We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV.	Vitamin D	35-44	C-X-C motif chemokine ligand 10	Homo sapiens	175-180
28376103-13	2017	Our important finding revealed that upon correction of vitamin D insufficiency or deficiency, the serum IP-10 and DPP IV levels were decreased significantly as compare to the placebo group (delta changes; 83.27 vs -133.80; 95% CI [-326.910, -40.758], p = 0.0125, and 271.04 vs -518.69; 95% CI [-1179,15, -59.781], p = 0.0305, respectively.	Vitamin D	55-64	C-X-C motif chemokine ligand 10	Homo sapiens	104-109
28232093-0	2017	Epigenomic PU.1-VDR crosstalk modulates vitamin D signaling.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	16-19
24693968-4	2014	Individual transgenic mouse strains selectively expressed BAC-derived mouse or human VDR proteins in appropriate vitamin D target tissues, thereby recapitulating the tissue-specific expression of endogenous mouse VDR.	Vitamin D	113-122	vitamin D receptor	Homo sapiens	85-88
25031885-1	2014	Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex.	Vitamin D	108-117	fibroblast growth factor 23	Homo sapiens	0-27
28325259-2	2017	Following binding of the active form of vitamin D, i.e., 1,25(OH)2D3 (also known as calcitriol) and interaction with co-activators and co-repressors, VDR regulates the expression of several different genes.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	150-153
28325259-3	2017	Although relatively little work has been carried out on VDR in human cancers, several epidemiological studies suggest that low circulating levels of vitamin D are associated with both an increased risk of developing specific cancer types and poor outcome in patients with specific diagnosed cancers.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	56-59
25031885-1	2014	Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex.	Vitamin D	108-117	fibroblast growth factor 23	Homo sapiens	29-34
24702903-9	2014	CONCLUSION: This study may support a future platform for the study of vitamin D during pregnancy and treatment of selective target populations with vitamin D and/or VDR "tissue-specific therapeutic intervention" for prevention of PTB.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	165-168
28093570-7	2017	Vitamin D supplementation in the HFD group significantly reduced body weight, NF-kappaB concentrations, BBB permeability and increased BDNF concentrations in the hippocampus.	Vitamin D	0-9	brain-derived neurotrophic factor	Rattus norvegicus	135-139
28093570-8	2017	CONCLUSIONS: Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-kappaB and elevation of BDNF concentrations and modulation of the BBB permeability in rats" hippocampus.	Vitamin D	13-22	brain-derived neurotrophic factor	Rattus norvegicus	113-117
24558199-3	2014	Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE.	Vitamin D	31-40	tryptophan hydroxylase 2	Homo sapiens	125-149
28301319-1	2017	BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	121-139
28301319-1	2017	BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	53-56
24558199-3	2014	Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE.	Vitamin D	31-40	tryptophan hydroxylase 2	Homo sapiens	151-155
24558199-3	2014	Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE.	Vitamin D	175-184	tryptophan hydroxylase 2	Homo sapiens	125-149
28355272-3	2017	In order to identify potential mechanisms underlying vitamin D effects in MS, we profiled epigenetic changes in vitamin D receptor (VDR) gene to identify genomic regulatory elements relevant to MS pathogenesis.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	112-130
24558199-3	2014	Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE.	Vitamin D	175-184	tryptophan hydroxylase 2	Homo sapiens	151-155
28355272-3	2017	In order to identify potential mechanisms underlying vitamin D effects in MS, we profiled epigenetic changes in vitamin D receptor (VDR) gene to identify genomic regulatory elements relevant to MS pathogenesis.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	132-135
24557774-2	2014	A number of studies have sought to define an association for disease with sequence variation in the VDR gene, encoding the ligand-activated nuclear hormone receptor for vitamin D.	Vitamin D	169-178	vitamin D receptor	Homo sapiens	100-103
28325820-1	2017	Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression.	Vitamin D	87-96	vitamin D receptor	Homo sapiens	0-18
24614234-4	2014	Fibroblast growth factor 23 (FGF23) is a bone-derived phosphaturic factor that regulates vitamin D and inorganic phosphate metabolism in the kidney.	Vitamin D	89-98	fibroblast growth factor 23	Mus musculus	0-27
28300755-6	2017	Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells.	Vitamin D	0-9	matrix metallopeptidase 28	Homo sapiens	72-77
28300755-6	2017	Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells.	Vitamin D	0-9	kallikrein related peptidase 4	Homo sapiens	82-92
28296915-6	2017	Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped.	Vitamin D	27-36	7-dehydrocholesterol reductase	Homo sapiens	70-75
28296915-6	2017	Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	190-193
24614234-4	2014	Fibroblast growth factor 23 (FGF23) is a bone-derived phosphaturic factor that regulates vitamin D and inorganic phosphate metabolism in the kidney.	Vitamin D	89-98	fibroblast growth factor 23	Mus musculus	29-34
24803805-4	2014	The active form of vitamin D, 1,25(OH)D3, acts on T cells to promote T helper (Th)2/regulatory T responses over Th1/Th17 responses; suppresses dendritic cell inflammatory activity; induces antibacterial activity; and regulates cytokine production in favor of an anti-inflammatory response.	Vitamin D	19-28	negative elongation factor complex member C/D	Homo sapiens	112-115
24518185-1	2014	OBJECTIVE: Mutations in the 24-hydroxylase gene, CYP24A1, have recently been reported to cause idiopathic infantile hypercalcemia (IIH), a rare disease presenting in the first year of life that is characterized by increased sensitivity to vitamin D, leading to severe symptomatic hypercalcemia.	Vitamin D	239-248	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	28-42
28242709-4	2017	Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in BC cells that correlates with increased survival in patients; strikingly, this signature is present in the normal mammary gland and is progressively lost in patients with metastatic BC.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	18-21
24518185-1	2014	OBJECTIVE: Mutations in the 24-hydroxylase gene, CYP24A1, have recently been reported to cause idiopathic infantile hypercalcemia (IIH), a rare disease presenting in the first year of life that is characterized by increased sensitivity to vitamin D, leading to severe symptomatic hypercalcemia.	Vitamin D	239-248	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	49-56
28253304-13	2017	Of the vitamin D-related genes, only CYP24A1 gene rs6013897 was associated with total hip BMD, but the association was weak and needs confirmation in other studies.	Vitamin D	7-16	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44
24571812-1	2014	AIM: Vitamin D performs its actions through the vitamin D receptor (VDR), which acts as a transcriptional factor.	Vitamin D	5-14	vitamin D receptor	Homo sapiens	48-66
28382877-4	2017	In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped.	Vitamin D	27-36	7-dehydrocholesterol reductase	Homo sapiens	124-176
28382877-4	2017	In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped.	Vitamin D	27-36	NAD synthetase 1	Homo sapiens	177-184
24571812-1	2014	AIM: Vitamin D performs its actions through the vitamin D receptor (VDR), which acts as a transcriptional factor.	Vitamin D	5-14	vitamin D receptor	Homo sapiens	68-71
28063327-10	2017	CONCLUSION: Newly diagnosed LN patients demonstrated elevated FGF23 levels that were positively correlated to urinary MCP1, independently of vitamin D levels and kidney function.	Vitamin D	141-150	fibroblast growth factor 23	Homo sapiens	62-67
24606079-7	2014	Vitamin D status was a significant predictor of the IL-6 to IL-10 cytokine ratio, and those participants defined as deficient were significantly more likely to have an IL-6 to IL-10 ratio &gt;2:1 compared with those defined as sufficient.	Vitamin D	0-9	interleukin 10	Homo sapiens	60-65
24606079-8	2014	CONCLUSIONS: This study demonstrated significant associations between low vitamin D status and markers of inflammation (including the ratio of IL-6 to IL-10) within elderly adults.	Vitamin D	74-83	interleukin 10	Homo sapiens	151-156
24647396-0	2014	Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.	Vitamin D	8-17	low density lipoprotein receptor	Mus musculus	116-128
28131132-1	2017	Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	0-27
28131132-1	2017	Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	29-34
24647396-2	2014	We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR(-/-)) mice fed a diet low in vitamin D.	Vitamin D	113-122	low density lipoprotein receptor	Mus musculus	56-68
24795646-3	2014	The description of increased vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) expression in macrophages following a pathogen challenge, has underlined the importance of intracrine vitamin D as key mediator of innate immune function.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	49-52
27017221-1	2017	The fibroblast growth factor (FGF) 23/Klotho axis is a principal regulator of phosphate hemostasis and vitamin D metabolism, but limited data is available on its role in the central nervous system.	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	4-37
27017221-1	2017	The fibroblast growth factor (FGF) 23/Klotho axis is a principal regulator of phosphate hemostasis and vitamin D metabolism, but limited data is available on its role in the central nervous system.	Vitamin D	103-112	klotho	Homo sapiens	38-44
27977320-1	2017	Context: The vitamin D receptor (VDR) and enzymes involved in activation (CYP2R1, CYP27B1) and inactivation (CYP24A1) of vitamin D are expressed in ovary, testes, and spermatozoa.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	33-36
27977320-1	2017	Context: The vitamin D receptor (VDR) and enzymes involved in activation (CYP2R1, CYP27B1) and inactivation (CYP24A1) of vitamin D are expressed in ovary, testes, and spermatozoa.	Vitamin D	13-22	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	109-116
24550213-8	2014	As proof of concept, the top upregulated gene was CYP24A1, a well-established vitamin D-responsive gene.	Vitamin D	78-87	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	50-57
27864003-0	2017	Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	99-117
27864003-1	2017	Hereditary vitamin D-resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	77-95
27864003-1	2017	Hereditary vitamin D-resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
24851888-14	2014	Using Logistic regression analysis, it was found that mutant genotype (GA/AA) of VDR (Bsm I) played an independently protective role in UC (OR = 0.328, P = 0.028) while mutant genotype (TC/CC) of VDR (Fok I) and vitamin D deficiency (&lt;50.0 nmol/L) had an interaction in UC (OR = 2.070, P = 0.006).	Vitamin D	212-221	vitamin D receptor	Homo sapiens	81-84
27864003-7	2017	Of the 33 vitamin D analogs, 5 showed much higher affinities for the mutant VDR (R274L) than 1alpha,25(OH)2D3, and 2alpha-[2-(tetrazol-2-yl)ethyl]-1alpha,25-(OH)2D3 showed the highest affinity.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	76-79
27043843-1	2017	Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	82-100
27043843-1	2017	Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	102-105
24378747-9	2014	Furthermore, there is increasing evidence that the activity of DHCR7 may affect chronic liver diseases by influencing vitamin D levels.	Vitamin D	118-127	7-dehydrocholesterol reductase	Homo sapiens	63-68
27423437-7	2017	The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio.	Vitamin D	52-61	interleukin 17A	Homo sapiens	102-108
27423437-7	2017	The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio.	Vitamin D	52-61	interleukin 17A	Homo sapiens	143-149
27423437-13	2017	The FoxP3+/IL-17A ratio in SLE patients after 6 months of vitamin D supplementation was higher than that in the baseline (p &lt; 0.001).	Vitamin D	58-67	interleukin 17A	Homo sapiens	11-17
27618536-14	2017	Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 and increased transcription of the catabolic gene CYP24A1 observed.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	159-166
24670704-0	2014	Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status [Short Communication].	Vitamin D	76-85	C-X-C motif chemokine ligand 10	Homo sapiens	16-22
27535551-4	2017	Furthermore, raising serum calcium levels in Cyp27b1-depleted mice directly increased FGF23 levels and indirectly enhanced the action of ambient vitamin D metabolites via the vitamin D receptor.	Vitamin D	145-154	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	175-193
24670704-6	2014	However, CXCL10 levels should be interpreted taking into account the baseline serum vitamin D levels of the TB patients.	Vitamin D	84-93	C-X-C motif chemokine ligand 10	Homo sapiens	9-15
28110703-1	2017	Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers.	Vitamin D	75-84	fibroblast growth factor 23	Homo sapiens	0-27
24736069-11	2014	Treatment with TSA increased H3K4me2 and H3K9ac and simultaneously decreased H3K9me2 at the CYP24A1 promoter and treatment with 5-Aza and/or TSA increased the recruitment of vitamin D receptor (VDR) to vitamin D response elements (VDRE) of the CYP24A1 promoter.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	194-197
28110703-1	2017	Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers.	Vitamin D	75-84	fibroblast growth factor 23	Homo sapiens	29-34
24736069-11	2014	Treatment with TSA increased H3K4me2 and H3K9ac and simultaneously decreased H3K9me2 at the CYP24A1 promoter and treatment with 5-Aza and/or TSA increased the recruitment of vitamin D receptor (VDR) to vitamin D response elements (VDRE) of the CYP24A1 promoter.	Vitamin D	174-183	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	244-251
24318991-2	2014	The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
27896829-2	2017	The role of vitamin D in autoimmune diseases has increased significantly in the recent past from its functions in calcium and phosphate homoeostasis, and it is now involved in the regulations and proliferations of Th1 and Th17 lymphocyte.	Vitamin D	12-21	negative elongation factor complex member C/D	Homo sapiens	214-217
27896829-8	2017	Vitamin D supplementation assists in autoimmune disorders by making qualitative and quantitative changes in the immune system (downregulation of Th1 and upregulations of Th2 cells).	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	145-148
24398649-0	2014	Effect of vitamin D supplementation on cathelicidin, IFN-gamma, IL-4 and Th1/Th2 transcription factors in young healthy females.	Vitamin D	10-19	negative elongation factor complex member C/D	Homo sapiens	73-76
28025137-1	2017	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	218-236
28025137-1	2017	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	238-241
24038189-1	2014	Bone is clearly a target of vitamin D and as expected, the vitamin D receptor (VDR) is expressed in osteoblasts.	Vitamin D	28-37	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	59-77
27856242-2	2017	Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	28-46
24038189-1	2014	Bone is clearly a target of vitamin D and as expected, the vitamin D receptor (VDR) is expressed in osteoblasts.	Vitamin D	28-37	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	79-82
24269661-1	2014	Primary cultures of human bone and vascular cells respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis (DNA) and energy metabolism measured by creatine kinase specific activity (CK) via binding to vitamin D receptors (VDR) which are expressed in these cells.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	237-256
27856242-2	2017	Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	48-51
24269661-1	2014	Primary cultures of human bone and vascular cells respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis (DNA) and energy metabolism measured by creatine kinase specific activity (CK) via binding to vitamin D receptors (VDR) which are expressed in these cells.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	258-261
24269661-2	2014	Vitamin D compounds also modulate the response to estradiol-17beta (E2) and the expression mRNAs of estrogen receptors (ERalpha and ERbeta), VDR, 25-hydroxy vitamin D3 1-alpha hydroxylase (1OHase) and lipoxygenases (12LO and 15LO).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	141-144
24316428-2	2014	Vitamin D elicits its bioactive actions by binding to its receptor, vitamin D receptor (VDR), on target cells and organs.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	68-86
28512681-7	2017	We also revealed an inverse association between the serum vitamin D and the percentage of CD8+ cells (p &lt; 0.05; r = 0.62) in atopic dermatitis.	Vitamin D	58-67	CD8a molecule	Homo sapiens	90-93
24316428-2	2014	Vitamin D elicits its bioactive actions by binding to its receptor, vitamin D receptor (VDR), on target cells and organs.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	88-91
28123720-2	2017	Vitamin D receptor has been shown to be expressed in several types of immune cells suggesting vitamin D may have immune regulatory roles.	Vitamin D	94-103	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
24248540-1	2014	The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
28123720-13	2017	However, in vitamin D-treated mice, the thymus indexes, the ratios of CD4+/CD8+, secretion of IL-2 and the proliferation index of spleen T lymphocytes were significantly increased (P&lt;0.05).	Vitamin D	12-21	CD4 antigen	Mus musculus	70-73
27407090-2	2017	Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	0-18
24447085-4	2014	Measured vitamin D is largely bound to vitamin D-binding protein (VDBP); VDBP levels are influenced by its gene (GC) haplotype.	Vitamin D	9-18	GC vitamin D binding protein	Homo sapiens	39-64
27407090-2	2017	Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	20-23
27407090-10	2017	The present findings of VDR expression are consistent with our previous results of circulating vitamin D biomarkers, which provide two converging lines of evidence supporting the putative benefits of vitamin D against aggressive breast cancer.	Vitamin D	200-209	vitamin D receptor	Homo sapiens	24-27
24447085-4	2014	Measured vitamin D is largely bound to vitamin D-binding protein (VDBP); VDBP levels are influenced by its gene (GC) haplotype.	Vitamin D	9-18	GC vitamin D binding protein	Homo sapiens	66-70
27915991-2	2017	The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression.	Vitamin D	113-122	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	4-22
27915991-2	2017	The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression.	Vitamin D	113-122	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
27915991-5	2017	In addition to epidemiological studies on vitamin D status, genome-wide analyses and cellular and animal experiments have shown that VDR is involved in the prevention of inflammatory bowel disease (IBD) and colorectal cancer (CRC).	Vitamin D	42-51	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	133-136
27915991-6	2017	VDR deletion in mice exaggerates colitis and colon tumorigenesis in experimental models, and treatment of mice with synthetic vitamin D analogues ameliorates pathological changes in these diseases.	Vitamin D	126-135	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
24447085-13	2014	The GC1s haplotype is associated with higher VDBP levels, resulting in less freely available vitamin D.	Vitamin D	93-102	GC vitamin D binding protein	Homo sapiens	45-49
24447085-14	2014	KEY MESSAGES: Vitamin D-binding protein (VDBP) haplotypes influence free vitamin D levels.	Vitamin D	73-82	GC vitamin D binding protein	Homo sapiens	14-39
24447085-14	2014	KEY MESSAGES: Vitamin D-binding protein (VDBP) haplotypes influence free vitamin D levels.	Vitamin D	73-82	GC vitamin D binding protein	Homo sapiens	41-45
27320333-5	2017	Conversely, RXR is able to form "nonpermissive" heterodimers with vitamin D receptor (VDR), thyroid receptor (TR) and retinoic acid receptor (RAR), which function only in the presence of vitamin D, T3 and retinoic acid, respectively.	Vitamin D	66-75	retinoid X receptor alpha	Homo sapiens	12-15
24428861-3	2014	Clinical research suggests that vitamin D treatment can improve compromised human muscular ability and increase muscle size, supported by loss of motor function and muscle mass in animals following VDR knockout, as well as increased muscle protein synthesis and ATP production following vitamin D supplementation.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	198-201
27320333-5	2017	Conversely, RXR is able to form "nonpermissive" heterodimers with vitamin D receptor (VDR), thyroid receptor (TR) and retinoic acid receptor (RAR), which function only in the presence of vitamin D, T3 and retinoic acid, respectively.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	86-89
24388225-6	2014	The serum IL-10 and IL-13 responses to muscular injury were significantly (both p&lt;0.05) increased in the vitamin D sufficient group.	Vitamin D	108-117	interleukin 10	Homo sapiens	10-15
28978869-2	2017	We investigated their possible association with vitamin D receptor (VDR) FOK1 polymorphisms (rs10735810) and dietary parameters such as calcium and vitamin D intake.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	68-71
27060335-5	2017	The inactivation of vitamin D is principally initiated by its 23- and 24-hydroxylation by CYP24A1.	Vitamin D	20-29	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	90-97
24466411-2	2014	A full vitamin D (refers to vitamin D2 and D3) endocrine system, characterized by a specific VDR (vitamin D receptor, member of the nuclear receptor family), specific vitamin D metabolizing CYP450 enzymes regulated by calciotropic hormones and a dedicated plasma transport-protein is only found in vertebrates.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	93-96
24466411-2	2014	A full vitamin D (refers to vitamin D2 and D3) endocrine system, characterized by a specific VDR (vitamin D receptor, member of the nuclear receptor family), specific vitamin D metabolizing CYP450 enzymes regulated by calciotropic hormones and a dedicated plasma transport-protein is only found in vertebrates.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	98-116
28787727-5	2017	Using candidate gene approach, obesity- (insulin-like growth factor 2 (IGF2), proopiomelanocortin (POMC)) and vitamin D metabolism-related genes (1-alfa-hydroxylase (CYP27B1), VDR) regulated by DNA methylation were selected.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	176-179
24466411-3	2014	In the earliest vertebrates (lamprey), vitamin D metabolism and VDR may well have originated from a duplication of a common PRX/VDR ancestor gene as part of a xenobiotic detoxification pathway.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	128-131
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	285-288
24416388-10	2014	Considering the negative feedback impact of cyp24a1 on the vitamin D responses, the identification of a novel, translational mechanism of cyp24a1 regulation might open new possibilities to overcome the current limitations of vitamin D as tumor therapeutic option.	Vitamin D	59-68	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	44-51
24416388-10	2014	Considering the negative feedback impact of cyp24a1 on the vitamin D responses, the identification of a novel, translational mechanism of cyp24a1 regulation might open new possibilities to overcome the current limitations of vitamin D as tumor therapeutic option.	Vitamin D	59-68	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	138-145
24416388-10	2014	Considering the negative feedback impact of cyp24a1 on the vitamin D responses, the identification of a novel, translational mechanism of cyp24a1 regulation might open new possibilities to overcome the current limitations of vitamin D as tumor therapeutic option.	Vitamin D	225-234	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	138-145
25207361-2	2014	The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
25207368-17	2014	Interestingly, increasing evidence now demonstrates an important function of the vitamin D endocrine system (VDES) for prevention of BCC, SCC and melanoma, identifying the vitamin D receptor as a tumor suppressor in the skin.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	172-190
25207372-2	2014	The major cell in the epidermis, the keratinocyte, not only produces vitamin D but contains the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and expresses the receptor for this metabolite, the vitamin D receptor (VDR), allowing the cell to respond to the 1,25(OH)2D that it produces.	Vitamin D	130-139	vitamin D receptor	Homo sapiens	230-248
25207372-2	2014	The major cell in the epidermis, the keratinocyte, not only produces vitamin D but contains the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and expresses the receptor for this metabolite, the vitamin D receptor (VDR), allowing the cell to respond to the 1,25(OH)2D that it produces.	Vitamin D	130-139	vitamin D receptor	Homo sapiens	250-253
25207372-8	2014	In this chapter we will first discuss recent data regarding potential mechanisms by which vitamin D signaling suppresses tumor formation, then focus on three general mechanisms that mediate tumor suppression by VDR in the skin: inhibition of proliferation and stimulation of differentiation, immune regulation, and stimulation of DNA damage repair (DDR).	Vitamin D	90-99	vitamin D receptor	Homo sapiens	211-214
25207373-4	2014	In addition to these known responses, there is now sufficient evidence to suggest that the local vitamin D system in skin, which includes local production of the active hormone, 1,25 dihydroxyvitamin D, together with metabolites of over-irradiation products, and vitamin D receptor(s), also provide an adaptive response to UV.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	263-281
23941558-5	2014	First, we demonstrated that human fetal lung (HFL)-1 cells express the vitamin D receptor (VDR) and that vitamin D, 25-hydroxyvitamin D [25(OH)D], or 1,25-dihydroxyvitamin D [1,25(OH)2D] induce VDR nuclear translocation and increase VDR-DNA binding activity.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	91-94
23941558-7	2014	Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2.	Vitamin D	0-9	prostaglandin E synthase	Homo sapiens	87-109
25537068-0	2014	Development of vitamin D analogs modulating the pocket structure of vitamin D receptor.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	68-86
25537068-5	2014	We focused on the structure of the LBP and discovered that vitamin D analogs with a branched side chain induce structural rearrangement of the amino acid residues lining the LBP.	Vitamin D	59-68	lipopolysaccharide binding protein	Homo sapiens	35-38
25537068-5	2014	We focused on the structure of the LBP and discovered that vitamin D analogs with a branched side chain induce structural rearrangement of the amino acid residues lining the LBP.	Vitamin D	59-68	lipopolysaccharide binding protein	Homo sapiens	174-177
23564710-1	2014	The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1alpha,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review series.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	217-235
24246681-1	2014	CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	291-309
24246681-1	2014	CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	50-53
24246681-1	2014	CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	291-309
24246681-1	2014	CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	50-53
24048755-1	2014	Vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	0-18
24048755-1	2014	Vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	20-23
23954530-9	2013	Given that 25(OH)D is hydroxylated by CYP27B1 to the bioactive 1,25(OH)2D form, and CYP24A1 catabolizes both 25(OH)D and 1,25(OH)2D to the inactive metabolites, respectively, our data indicate that the elevated activity of CYP24A1 in the placenta may play a key role in the development of vitamin D deficiency in GDM.	Vitamin D	289-298	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	84-91
24007655-3	2013	The study aimed to test whether vitamin D binding protein (VDBP or GC-group component) and vitamin D receptor (VDR) gene polymorphisms were associated with asthma characteristics as well as vitamin D level in Egyptian children.	Vitamin D	32-41	GC vitamin D binding protein	Homo sapiens	59-63
23744843-0	2013	Analyses of RANK and RANKL in the post-GWAS context: functional evidence of vitamin D stimulation through a RANKL distal region.	Vitamin D	76-85	TNF superfamily member 11	Homo sapiens	108-113
23744843-9	2013	In conclusion, the GWA-associated SNP rs9594738 lies in a region involved in transcription regulation through which vitamin D could be regulating RANKL expression and bone mineral density.	Vitamin D	116-125	TNF superfamily member 11	Homo sapiens	146-151
24011919-0	2013	Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats.	Vitamin D	67-76	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	15-63
24011919-3	2013	The present study investigated the activation of PPAR-gamma as novel mechanism in vitamin D-mediated protection against ischemia reperfusion-induced acute kidney injury (AKI) in rats.	Vitamin D	82-91	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	49-59
27941640-8	2016	Among the factors increasing plasma FGF23 concentration, active vitamin D analogues play a significant role.	Vitamin D	64-73	fibroblast growth factor 23	Homo sapiens	36-41
24202452-5	2013	We will examine two pathways, beta-catenin (CTNNB) and hedgehog (HH), that are regulated by vitamin D signaling and may contribute to the dysregulated proliferation and differentiation in the absence of VDR.	Vitamin D	92-101	catenin (cadherin associated protein), beta 1	Mus musculus	30-42
24202452-7	2013	Finally we will examine the change in long non-coding RNA (LncRNA) expression in VDR null keratinocytes that in other cells is associated with malignant transformation, a potential newly appreciated mechanism by which vitamin D signaling is protective against NMSC.	Vitamin D	218-227	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	81-84
27768599-1	2016	Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/beta-catenin/TCF tumor suppressor pathway.	Vitamin D	0-9	catenin (cadherin associated protein), beta 1	Mus musculus	129-141
23877588-7	2013	Other factors such as dietary vitamin D compounds, calcium, and metabolic acidosis all increase FGF-23 levels.	Vitamin D	30-39	fibroblast growth factor 23	Homo sapiens	96-102
27769995-0	2016	Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation.	Vitamin D	9-18	Pannexin 1	Rattus norvegicus	108-113
23911750-1	2013	Vitamin D activity requires an adequate vitamin D status as indicated by the serum level of 25-hydroxyvitamin D and appropriate expression of genes coding for vitamin D receptor and 25-hydroxyvitamin D 1alpha-hydroxylase, the enzyme which converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	159-177
27813049-1	2016	The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues.	Vitamin D	63-72	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	123-130
27902451-3	2016	Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	81-84
27895321-4	2016	The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	91-94
27769055-1	2016	Here, we evaluated the expression of CYP24A1, a protein that inactivates vitamin D in tissues.	Vitamin D	73-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44
24124566-2	2013	The biological functions of VDBP include acting as a carrier protein for vitamin D metabolites, the clearance of actin that is released during tissue injury and the augmentation of the pro-inflammatory response.	Vitamin D	73-82	GC vitamin D binding protein	Homo sapiens	28-32
27879395-1	2016	Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of alpha-Klotho (alpha-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney.	Vitamin D	166-175	fibroblast growth factor 23	Mus musculus	0-27
23381556-2	2013	Some studies have reported associations between vitamin D pathway genes such as VDR, GC and CYP27B1 with body mass index (BMI) and waist circumference (WC); however, the findings have been inconsistent.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	80-83
27062466-2	2016	The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS).	Vitamin D	74-83	transthyretin	Homo sapiens	119-122
27062466-5	2016	RESULTS: The severity levels of CTS were at a 75% mild level in the vitamin D deficiency group and a 47.1% mild level in the vitamin D normal group, with a significant difference between groups (p = 0.008).	Vitamin D	68-77	transthyretin	Homo sapiens	32-35
27062466-5	2016	RESULTS: The severity levels of CTS were at a 75% mild level in the vitamin D deficiency group and a 47.1% mild level in the vitamin D normal group, with a significant difference between groups (p = 0.008).	Vitamin D	125-134	transthyretin	Homo sapiens	32-35
27062466-6	2016	Correlation analyses revealed positive correlations between body mass index and DN4 scores (r = 0.499, p = 0.025) and between vitamin D levels and CTS severity (r = 0.364, p = 0.004) in the vitamin D deficiency group.	Vitamin D	126-135	transthyretin	Homo sapiens	147-150
27062466-7	2016	CONCLUSIONS: The present findings demonstrated that CTS may be triggered by vitamin D deficiency, and that the severity of CTS was correlated with vitamin D levels in the deficiency group.	Vitamin D	76-85	transthyretin	Homo sapiens	52-55
24051166-5	2013	Many non-classical effects of vitamin D are suggested by the quasi-ubiquitous presence of the vitamin D receptor and by myriads of studies showing an association between vitamin D deficiency/insufficiency and an increased incidence or a poor prognostic of many diseases.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	94-112
27062466-7	2016	CONCLUSIONS: The present findings demonstrated that CTS may be triggered by vitamin D deficiency, and that the severity of CTS was correlated with vitamin D levels in the deficiency group.	Vitamin D	147-156	transthyretin	Homo sapiens	123-126
27062466-8	2016	Additionally, there was a correlation between weight gain and neuropathic pain intensity in CTS patients with vitamin D deficiency.	Vitamin D	110-119	transthyretin	Homo sapiens	92-95
27062466-9	2016	The present findings indicate that vitamin D levels should be assessed in CTS patients.	Vitamin D	35-44	transthyretin	Homo sapiens	74-77
24073860-0	2013	Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults.	Vitamin D	58-67	NAD synthetase 1	Homo sapiens	24-31
27498418-1	2016	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, suppressing renal phosphate reabsorption and vitamin D hormone synthesis in proximal tubules, and stimulating calcium reabsorption in distal tubules of the kidney.	Vitamin D	108-117	fibroblast growth factor 23	Mus musculus	0-27
24073860-1	2013	BACKGROUND: Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals.	Vitamin D	59-68	NAD synthetase 1	Homo sapiens	200-216
27498418-1	2016	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, suppressing renal phosphate reabsorption and vitamin D hormone synthesis in proximal tubules, and stimulating calcium reabsorption in distal tubules of the kidney.	Vitamin D	108-117	fibroblast growth factor 23	Mus musculus	29-34
27569350-0	2016	Vitamin D-dependent chromatin association of CTCF in human monocytes.	Vitamin D	0-9	CCCTC-binding factor	Homo sapiens	45-49
24073860-10	2013	CONCLUSIONS: The GC and NADSYN1 genes are associated with the vitamin D status and might contribute to dyslipidemia and overweight independently of 25(OH)D levels.	Vitamin D	62-71	NAD synthetase 1	Homo sapiens	24-31
27569350-6	2016	A self-organizing map approach subdivided the vitamin D-sensitive CTCF sites into seven classes that can be distinguished by participation in DNA loop formation, binding to open chromatin, carrying binding motifs for CTCF or its relative BORIS, overlap with transcription start site (TSS) regions and binding of VDR.	Vitamin D	46-55	CCCTC-binding factor	Homo sapiens	66-70
27569350-6	2016	A self-organizing map approach subdivided the vitamin D-sensitive CTCF sites into seven classes that can be distinguished by participation in DNA loop formation, binding to open chromatin, carrying binding motifs for CTCF or its relative BORIS, overlap with transcription start site (TSS) regions and binding of VDR.	Vitamin D	46-55	CCCTC-binding factor	Homo sapiens	217-221
23735647-1	2013	Previous studies have suggested that vitamin D deficiency might contribute to the pathogenesis of heart failure (HF); however, limited data are available on the association of vitamin D-binding protein (VDBP)--a major transport protein for vitamin D--and the development of HF.	Vitamin D	176-185	GC vitamin D binding protein	Homo sapiens	203-207
27569350-6	2016	A self-organizing map approach subdivided the vitamin D-sensitive CTCF sites into seven classes that can be distinguished by participation in DNA loop formation, binding to open chromatin, carrying binding motifs for CTCF or its relative BORIS, overlap with transcription start site (TSS) regions and binding of VDR.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	312-315
27569350-9	2016	In conclusion, vitamin D-sensitive CTCF sites provide further mechanistic details to the epigenome-wide understanding of 1,25(OH)2D3-mediated gene regulation.	Vitamin D	15-24	CCCTC-binding factor	Homo sapiens	35-39
27393303-0	2016	Nonspecific binding of a frequently used vitamin D receptor (VDR) antibody: important implications for vitamin D research in human health.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	61-64
23463632-1	2013	In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ).	Vitamin D	31-40	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	101-108
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	negative elongation factor complex member C/D	Homo sapiens	80-83
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	CD8a molecule	Homo sapiens	89-92
27318428-8	2016	In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median.	Vitamin D	16-25	CD8a molecule	Homo sapiens	168-171
27318428-11	2016	CONCLUSIONS: Vitamin D levels may together with cortisol levels and gestational age have an effect on Th1/Th2 balance and the prevalence of plasmocytoid dendritic cells in the preterm newborn.	Vitamin D	13-22	negative elongation factor complex member C/D	Homo sapiens	102-105
23944708-0	2013	Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	72-90
27341425-0	2016	Association between vitamin D and depressive symptoms varies by season: Results from the German Health Interview and Examination Survey for Adults (DEGS1).	Vitamin D	20-29	delta 4-desaturase, sphingolipid 1	Homo sapiens	148-153
23944708-2	2013	Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disease, is caused by mutations in the VDR.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
27741157-2	2016	Vitamin D acts by binding to the vitamin D receptor, which is present in a variety of tissues; for this reason it is considered a hormone.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	33-51
23818717-8	2013	In the whole cohort and the vitamin D-insufficient group, serum 25(OH)D was inversely associated with IL-17 (log IL-17; beta = -0.83, p = 0.04; beta = -0.63, p = 0.004, respectively) by univariate analysis, which persisted after adjustment for season, and in multivariate analysis after adjustment for confounders (log IL-17; beta = -0.74, p = 0.04; beta = -0.53, p = 0.02).	Vitamin D	28-37	interleukin 17A	Homo sapiens	102-107
26282157-9	2016	These data suggest that vitamin D and calcium signaling are necessary components of the epidermal response to wounding, likely by regulating stem cell activation through increased beta-catenin transcriptional activity.	Vitamin D	24-33	catenin (cadherin associated protein), beta 1	Mus musculus	180-192
26361014-12	2016	VDR mRNA levels in tibiae from vitamin D deficient mice were 0.7 fold lower than those in control mice.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
26429395-2	2016	Since adipocytes express VDR and obesity is a known risk factor for cancer, vitamin D actions in adipose tissue may contribute to its cancer protective effects.	Vitamin D	76-85	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	25-28
26523676-2	2016	The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), serves as a ligand of the nuclear receptor vitamin D receptor (VDR).	Vitamin D	32-41	vitamin D receptor	Homo sapiens	151-154
23818717-11	2013	Maintaining normal serum vitamin D levels may protect against IL-17-mediated inflammation and vascular dysfunction in RA.	Vitamin D	25-34	interleukin 17A	Homo sapiens	62-67
26523676-6	2016	Primary and secondary vitamin D target genes being up- and down-regulated were related to changes in the epigenome of THP-1 cells, such as 1,25(OH)2D3-dependent chromatin opening and modulation of the genome-wide association of the transcription factors VDR and CCCTC-binding factor (CTCF) with their respective genomic binding sites.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	254-257
23830177-13	2013	Considering the relation among vitamin D deficiency, increased risk of PE, and the role of annexin A1 in the resolution of inflammation, production of antibody against annexin A1 and DBP may be considered a new auto-immune hypothesis in pre-eclampsia that calls for further investigation in future work.	Vitamin D	31-40	annexin A1	Homo sapiens	168-178
26686945-6	2016	There was limited overlap between genetic determinants of vitamin D status and those associated with non-skeletal health outcomes: polymorphisms in DBP, CYP2R1 and DHCR7 were the most frequent to be reported to associate with circulating concentrations of 25(OH)D, while polymorphisms in VDR were most commonly reported to associate with non-skeletal health outcomes, among which infectious and autoimmune diseases were the most represented.	Vitamin D	58-67	7-dehydrocholesterol reductase	Homo sapiens	164-169
23030238-10	2013	LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment.	Vitamin D	98-107	C-C motif chemokine ligand 5	Homo sapiens	21-27
26690785-2	2016	Global Vdr deletion in a mouse model (Vdr-/-) results in hypocalcemia, secondary hyperparathyroidism and bone features typical of vitamin D-dependent rickets type II.	Vitamin D	130-139	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	7-10
26690785-2	2016	Global Vdr deletion in a mouse model (Vdr-/-) results in hypocalcemia, secondary hyperparathyroidism and bone features typical of vitamin D-dependent rickets type II.	Vitamin D	130-139	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	38-41
23030238-10	2013	LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment.	Vitamin D	98-107	C-X-C motif chemokine ligand 13	Homo sapiens	58-61
23837623-0	2013	DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes.	Vitamin D	33-42	7-dehydrocholesterol reductase	Homo sapiens	0-5
23837623-10	2013	CONCLUSIONS: Our results suggest that genetic variation in DHCR7 is the major adaptation affecting vitamin D metabolism in recent evolutionary history which helped early humans to avoid severe vitamin D deficiency and enabled them to inhabit areas further from the equator.	Vitamin D	99-108	7-dehydrocholesterol reductase	Homo sapiens	59-64
23748358-0	2013	FGF23 modifies the relationship between vitamin D and cardiac remodeling.	Vitamin D	40-49	fibroblast growth factor 23	Homo sapiens	0-5
27600601-0	2016	CYP24A1-induced vitamin D insufficiency promotes breast cancer growth.	Vitamin D	16-25	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
27600601-2	2016	The vitamin D 24-hydroxylase CYP24A1 functions in vitamin D target tissues to degrade the hormonal form of vitamin D.	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	29-36
23748358-1	2013	BACKGROUND: There is growing evidence to support an important role for vitamin D and related hormones, parathyroid hormone and fibroblast growth factor 23 (FGF23), on cardiac remodeling in chronic kidney disease.	Vitamin D	71-80	fibroblast growth factor 23	Homo sapiens	156-161
27600601-2	2016	The vitamin D 24-hydroxylase CYP24A1 functions in vitamin D target tissues to degrade the hormonal form of vitamin D.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	4-28
23636220-4	2013	Single-nucleotide polymorphisms (SNPs) in the DHCR7/NADSYN1 (nicotinamide adenine dinucleotide synthase 1) and CYP2R1 loci, previously associated with circulating vitamin D levels, were tested in UK RA cases (n=3870) and controls (n=8430).	Vitamin D	163-172	7-dehydrocholesterol reductase	Homo sapiens	46-51
27600601-2	2016	The vitamin D 24-hydroxylase CYP24A1 functions in vitamin D target tissues to degrade the hormonal form of vitamin D.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	29-36
27600601-5	2016	In addition, suppression of vitamin D metabolism following knockdown of CYP24A1 significantly reduced tumor growth in vivo.	Vitamin D	28-37	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	72-79
27784318-10	2016	Different from normal FGF23 and PTH, serum 25-hydroxyvitamin D was significantly lower in Ank KI/KI mice and vitamin D insufficiency was found in four out of seven CMD patients.	Vitamin D	53-62	progressive ankylosis	Mus musculus	90-93
23636220-4	2013	Single-nucleotide polymorphisms (SNPs) in the DHCR7/NADSYN1 (nicotinamide adenine dinucleotide synthase 1) and CYP2R1 loci, previously associated with circulating vitamin D levels, were tested in UK RA cases (n=3870) and controls (n=8430).	Vitamin D	163-172	NAD synthetase 1	Homo sapiens	52-59
23416104-6	2013	In this research, we demonstrated that some novel vitamin D derivatives (12-MP, 13-MP, 15-MP and 16-LP) have strong transactivation activities in spite of lower affinity for VDR than 1.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	174-177
27736940-2	2016	Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	55-58
23401126-2	2013	The ligand-bound vitamin D receptor (VDR), heterodimerized with retinoid X receptor, interacts with vitamin D response elements (VDREs) to regulate gene expression.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
27716304-6	2016	The vitamin D load increased the average plasma 25(OH)D concentration to 116 +- 34 nmol/L (mean +- SD); the median concentration was 122 nmol/L (interquartile range 103-134); VDBP concentrations did not change.	Vitamin D	4-13	GC vitamin D binding protein	Homo sapiens	175-179
27716192-0	2016	Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	50-53
27716192-0	2016	Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.	Vitamin D	26-35	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	55-62
23401126-2	2013	The ligand-bound vitamin D receptor (VDR), heterodimerized with retinoid X receptor, interacts with vitamin D response elements (VDREs) to regulate gene expression.	Vitamin D	17-26	retinoid X receptor alpha	Homo sapiens	64-83
27435264-9	2016	In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	74-77
27435264-9	2016	In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	129-132
23401126-4	2013	OBJECTIVE: To study a protective role of vitamin D in multiple sclerosis (MS), it is important to characterize the global molecular network of VDR target genes (VDRTGs) in immune cells.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	143-146
23657931-6	2013	Poor vitamin D status affects muscle strength, and vitamin D may participate in protein synthesis through the actions of the vitamin D receptor in muscle tissue.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	125-143
27106018-9	2016	CONCLUSIONS: We show for the first time that progestins and vitamin D synergistically reduce cell viability and induce apoptosis in ovarian cells and that progestins PR-dependently inhibit CAL-induced CYP24A1, thus extending CAL activity.	Vitamin D	60-69	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	201-208
23767916-9	2013	IL-17 levels were significantly increased in the low dose group, while patients receiving high dose vitamin D had a heterogeneous IL-17 response.	Vitamin D	100-109	interleukin 17A	Homo sapiens	130-135
23767916-12	2013	CONCLUSION: Vitamin D supplementation to IFN-beta treated PwMS, at the doses used, seems safe and associated with dose-dependent changes in IL-17 serum levels, while not affecting IFN-beta related FLS.	Vitamin D	12-21	interleukin 17A	Homo sapiens	140-145
23585425-10	2013	The acute colitis model induced in combination with a vitamin D-deficient diet resulted in increased morbidity, receptor downregulation, inflammatory marker expression, and Snail and Snail2 upregulation.	Vitamin D	54-63	snail family zinc finger 1	Mus musculus	173-178
26943611-2	2016	FGF23 was originally shown to play a central role in phosphate (Pi) and vitamin D metabolism, and a number of diseases associated with dysregulated Pi metabolism have been attributed to abnormal FGF23 signaling activities.	Vitamin D	72-81	fibroblast growth factor 23	Homo sapiens	0-5
26943611-3	2016	The discovery of Klotho as a co-receptor for FGF23 signaling has also accelerated understanding on the molecular mechanisms underlying Pi and vitamin D metabolism.	Vitamin D	142-151	klotho	Homo sapiens	17-23
23602862-8	2013	CONCLUSIONS: Low vitamin D status is associated with the presence of larger AAA in older men, and there is a graded inverse relationship between 25(OH)D concentrations and AAA diameter.	Vitamin D	17-26	AAA1	Homo sapiens	76-79
26943611-3	2016	The discovery of Klotho as a co-receptor for FGF23 signaling has also accelerated understanding on the molecular mechanisms underlying Pi and vitamin D metabolism.	Vitamin D	142-151	fibroblast growth factor 23	Homo sapiens	45-50
27573000-5	2016	Other proteins modulated by vitamin D play important roles in calcium regulation e.g., calbindin 1 (CALB1) and transient receptor potential cation channel 6 (TRPV6).	Vitamin D	28-37	transient receptor potential cation channel subfamily V member 6	Homo sapiens	158-163
23319826-6	2013	RESULTS: In a linear regression model adjusting for month of blood sampling, age, and sex, vitamin D concentrations were predicted by GC genotype (P &lt; 0.001), CYP2R1 genotype (P = 0.068), and DHCR7 genotype (P &lt; 0.001), with a coefficient of determination (r(2)) of 0.175.	Vitamin D	91-100	7-dehydrocholesterol reductase	Homo sapiens	195-200
27215557-3	2016	Klotho and FGF23 are crucial components for the regulation of vitamin D metabolism and subsequently blood phosphate levels.	Vitamin D	62-71	klotho	Homo sapiens	0-6
27215557-3	2016	Klotho and FGF23 are crucial components for the regulation of vitamin D metabolism and subsequently blood phosphate levels.	Vitamin D	62-71	fibroblast growth factor 23	Homo sapiens	11-16
23971693-6	2013	Preclinical studies from our laboratory have identified that vitamin D deficiency exacerbates proteinuria and hypertension in experimental PKD, and that this is reversed by treatment with vitamin D receptor agonist.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	188-206
26513595-3	2016	An elevated expression of the CYP24A1 leads to the deficiency of vitamin D and resistance to vitamin D therapy.	Vitamin D	65-74	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
23212742-2	2013	Human CYP24A1, CYP3A4, and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse drug response.	Vitamin D	79-88	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	6-13
26513595-3	2016	An elevated expression of the CYP24A1 leads to the deficiency of vitamin D and resistance to vitamin D therapy.	Vitamin D	93-102	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
23443925-1	2013	Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism.	Vitamin D	111-120	fibroblast growth factor 23	Homo sapiens	0-27
23443925-1	2013	Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism.	Vitamin D	111-120	fibroblast growth factor 23	Homo sapiens	29-34
23530237-0	2013	Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium.	Vitamin D	24-33	sclerostin	Mus musculus	0-10
23385000-0	2013	Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.	Vitamin D	0-9	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	25-30
23385000-6	2013	We hypothesized that vitamin D reduces proteinuria by affecting TRPC6 expression in podocytes.	Vitamin D	21-30	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	64-69
23385000-15	2013	These results demonstrate that vitamin D down-regulates the enhanced TRPC6 expression in in vivo and in vitro podocyte injury, possibly through a direct effect on TRPC6 promoter activity.	Vitamin D	31-40	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	69-74
23385000-15	2013	These results demonstrate that vitamin D down-regulates the enhanced TRPC6 expression in in vivo and in vitro podocyte injury, possibly through a direct effect on TRPC6 promoter activity.	Vitamin D	31-40	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	163-168
23385000-16	2013	This TRPC6 down-regulation could contribute to the antiproteinuric effect of vitamin D.	Vitamin D	77-86	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	5-10
23293122-7	2013	CONCLUSIONS: The results of this study show that 1,25(OH)2D-24-hydroxylase deficiency due to bi-allelic mutations in CYP24A1 causes elevated serum vitamin D, hypercalciuria, nephrocalcinosis, and renal stones.	Vitamin D	147-156	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
23311753-3	2013	We hypothesised that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR).	Vitamin D	95-104	vitamin D receptor	Homo sapiens	163-181
23311753-3	2013	We hypothesised that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR).	Vitamin D	95-104	vitamin D receptor	Homo sapiens	183-186
23247634-6	2013	Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2.	Vitamin D	19-28	sirtuin 1	Homo sapiens	111-117
23247634-6	2013	Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2.	Vitamin D	64-73	sirtuin 1	Homo sapiens	87-93
23247634-6	2013	Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2.	Vitamin D	64-73	sirtuin 1	Homo sapiens	111-117
23247634-7	2013	ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1.	Vitamin D	19-28	sirtuin 1	Homo sapiens	54-60
23247634-7	2013	ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1.	Vitamin D	19-28	sirtuin 1	Homo sapiens	145-151
23247634-8	2013	SirT-1 inhibition by Sirtinol reverted the vitamin D anti-oxidant effects.	Vitamin D	43-52	sirtuin 1	Homo sapiens	0-6
23247634-9	2013	Thus, vitamin D significantly reduced the endothelial malfunction and damage caused by oxidative stress, through the activation of MEKs/ERKs/SirT-1 axis.	Vitamin D	6-15	sirtuin 1	Homo sapiens	141-147
23458303-1	2013	A one-dimensional model for the transport of vitamin D(3) in an osteoblast cell is proposed, from its entry through the membrane to its activation of RANKL synthesis in the nucleus.	Vitamin D	45-54	TNF superfamily member 11	Homo sapiens	150-155
23449998-5	2013	The IFN-gamma-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-beta and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.	Vitamin D	33-42	interleukin 10	Homo sapiens	117-122
23322908-4	2013	Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-beta peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression.	Vitamin D	0-9	interleukin 10	Homo sapiens	134-148
23471660-1	2013	Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism.	Vitamin D	136-145	fibroblast growth factor 23	Homo sapiens	10-37
23471660-1	2013	Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism.	Vitamin D	136-145	fibroblast growth factor 23	Homo sapiens	39-44
23471660-2	2013	In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	68-73
23021843-4	2013	An alternative SPR method, based on the indirect determination of vitamin D by means of Vitamin D Binding Protein (VDBP), led to a further sensitivity increase reaching a LOD of 45 ng/ml which is really close to the fixed accomplishment.	Vitamin D	66-75	GC vitamin D binding protein	Homo sapiens	88-113
23021843-4	2013	An alternative SPR method, based on the indirect determination of vitamin D by means of Vitamin D Binding Protein (VDBP), led to a further sensitivity increase reaching a LOD of 45 ng/ml which is really close to the fixed accomplishment.	Vitamin D	66-75	GC vitamin D binding protein	Homo sapiens	115-119
23266184-1	2013	From our research of nonsecosteroidal vitamin D(3) derivatives with gamma hydroxy carboxylic acid, we identified compound 6, with two CF(3) groups in the side chain, as a most potent vitamin D receptor (VDR) agonist that shows superagonistic activity in VDRE reporter gene assay, MG-63 osteocalcin production assay and HL-60 cell differentiation assay.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	183-201
23266184-1	2013	From our research of nonsecosteroidal vitamin D(3) derivatives with gamma hydroxy carboxylic acid, we identified compound 6, with two CF(3) groups in the side chain, as a most potent vitamin D receptor (VDR) agonist that shows superagonistic activity in VDRE reporter gene assay, MG-63 osteocalcin production assay and HL-60 cell differentiation assay.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	203-206
22782502-1	2013	The hormonal metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	129-147
22782502-1	2013	The hormonal metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	149-152
22782502-2	2013	When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1,25D.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	24-27
22782502-2	2013	When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1,25D.	Vitamin D	109-118	retinoid X receptor alpha	Homo sapiens	47-66
22782502-2	2013	When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1,25D.	Vitamin D	109-118	retinoid X receptor alpha	Homo sapiens	68-71
22782502-3	2013	By recruiting complexes of either coactivators or corepressors, ligand-activated VDR-RXR modulates the transcription of genes encoding proteins that promulgate the traditional functions of vitamin D, including signaling intestinal calcium and phosphate absorption to effect skeletal and calcium homeostasis.	Vitamin D	189-198	vitamin D receptor	Homo sapiens	81-84
22782502-3	2013	By recruiting complexes of either coactivators or corepressors, ligand-activated VDR-RXR modulates the transcription of genes encoding proteins that promulgate the traditional functions of vitamin D, including signaling intestinal calcium and phosphate absorption to effect skeletal and calcium homeostasis.	Vitamin D	189-198	retinoid X receptor alpha	Homo sapiens	85-88
22782502-6	2013	Finally, alternative, low-affinity, non-vitamin D VDR ligands, e.g., lithocholic acid, docosahexaenoic acid, and curcumin, have been reported.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	50-53
22968766-10	2013	Further research is needed to fully characterize molecular mechanisms of vitamin D action on muscle cells downstream of the VDR, describe the effects on muscle morphology and contractility, and determine whether these molecular and cellular effects translate into clinical improvements in physical function.	Vitamin D	73-82	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	124-127
22915280-6	2013	The results showed a statistically significant positive correlation between the levels of ALP with IFN-gamma, PTH with IL-17 and a significant negative correlation between P with IL-10 in vitamin D deficient group.	Vitamin D	188-197	interleukin 10	Homo sapiens	179-184
27105398-17	2016	CYP24A1 deficiency should be considered in patients with unexplained vitamin D-mediated hypercalcemia.	Vitamin D	69-78	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
23284004-2	2013	Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).	Vitamin D	32-41	fibroblast growth factor 23	Homo sapiens	141-168
26869016-2	2016	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	61-79
26869016-2	2016	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	81-84
26869016-2	2016	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	90-124
23284004-2	2013	Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).	Vitamin D	32-41	fibroblast growth factor 23	Homo sapiens	170-176
26869016-2	2016	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	126-130
26869016-2	2016	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	174-177
23284004-3	2013	OBJECTIVE: The aim was to determine the effects of high-dose vitamin D on circulating concentrations of 1,25(OH)(2) vitamin D and FGF-23 in patients with osteoporosis and vitamin D insufficiency.	Vitamin D	61-70	fibroblast growth factor 23	Homo sapiens	130-136
26869016-2	2016	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	182-186
23284004-9	2013	There was a positive correlation between FGF-23 and serum phosphate (r = 0.36, P = .024) and calcium (r = 0.532, P &lt; .001) and a negative correlation between total 1,25(OH)(2)-vitamin D and FGF-23 (r = -0.32, P = .036) at 3 months.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	41-47
23284004-10	2013	CONCLUSIONS: High-dose vitamin D increases 1,25(OH)(2)-vitamin D and FGF-23 concentration.	Vitamin D	23-32	fibroblast growth factor 23	Homo sapiens	69-75
23284004-11	2013	Further studies are required to determine whether adjusting vitamin D dose and frequency to minimize increases in FGF-23 may prevent the adverse outcomes associated with high-dose intermittent vitamin D supplementation.	Vitamin D	193-202	fibroblast growth factor 23	Homo sapiens	114-120
27686292-1	2016	OBJECTIVE: To compare the pattern of Vitamin D receptor (VDR) polymorphisms (Apa I and Fok I) in Type I Diabetes mellitus (T1DM) as cases vs healthy population as control and to investigate the association of VDR polymorphism with vitamin D levels in cases and controls.	Vitamin D	231-240	vitamin D receptor	Homo sapiens	37-55
23206185-2	2013	Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism.	Vitamin D	164-173	fibroblast growth factor 23	Homo sapiens	29-34
27154413-12	2016	Thus, 1,25(OH)2D down-regulation of the glutamine transporter, SLC1A5, may facilitate vitamin D prevention of breast cancer.	Vitamin D	86-95	solute carrier family 1 member 5	Homo sapiens	63-69
27174721-1	2016	BACKGROUND: Vitamin D is a chemopreventive agent that acts against colorectal carcinogenesis in vivo and in vitro through vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	122-140
27174721-1	2016	BACKGROUND: Vitamin D is a chemopreventive agent that acts against colorectal carcinogenesis in vivo and in vitro through vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	142-145
23206185-2	2013	Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism.	Vitamin D	164-173	klotho	Homo sapiens	67-73
23206185-2	2013	Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism.	Vitamin D	164-173	klotho	Homo sapiens	75-77
23652546-8	2013	Studies have also documented negative effect of FGF23/klotho system on vitamin D metabolism and Na/Pi cotransporter activities.	Vitamin D	71-80	fibroblast growth factor 23	Homo sapiens	48-53
27475231-1	2016	Vitamin D supplementation in humans should be accompanied by calcium administration to avoid bone demineralization through vitamin D receptor signaling.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	123-141
27450565-3	2016	To directly examine this signaling relationship, in the present study we have over-expressed the vitamin D receptor (VDR) in neuroblastoma SH-SY5Y cells in order to examine the mechanisms by which the active vitamin D hormone, 1,25(OH)2D3, via its receptor VDR, affects DA production and turnover.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	117-120
23652546-8	2013	Studies have also documented negative effect of FGF23/klotho system on vitamin D metabolism and Na/Pi cotransporter activities.	Vitamin D	71-80	klotho	Homo sapiens	54-60
23652552-12	2013	Fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor that influences vitamin D metabolism and renal reabsorption of Pi.	Vitamin D	83-92	fibroblast growth factor 23	Mus musculus	0-27
27401223-5	2016	We describe the functional environment around DHCR7, including pharmacological DHCR7 inhibitors and cholesterol and vitamin D synthesis.	Vitamin D	116-125	7-dehydrocholesterol reductase	Homo sapiens	46-51
23652552-12	2013	Fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor that influences vitamin D metabolism and renal reabsorption of Pi.	Vitamin D	83-92	fibroblast growth factor 23	Mus musculus	29-34
23879537-5	2013	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) functions as a steroid hormone that, when bound to its nuclear vitamin D receptor, is able to regulate target gene expression.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	130-148
27697512-0	2016	DHCR7: A vital enzyme switch between cholesterol and vitamin D production.	Vitamin D	53-62	7-dehydrocholesterol reductase	Homo sapiens	0-5
27697512-3	2016	Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin.	Vitamin D	86-95	7-dehydrocholesterol reductase	Homo sapiens	35-40
27697512-4	2016	Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production.	Vitamin D	80-89	7-dehydrocholesterol reductase	Homo sapiens	6-11
24494038-5	2013	Main products of CYP11A1-mediated metabolism on vitamin D are non-calcemic and non-toxic at relatively high doses and serve as partial agonists on the vitamin D receptor.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	151-169
27697512-5	2016	Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis.	Vitamin D	72-81	7-dehydrocholesterol reductase	Homo sapiens	22-27
27697512-6	2016	This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis.	Vitamin D	198-207	7-dehydrocholesterol reductase	Homo sapiens	67-72
24617042-12	2013	In conclusion, 84.8% of children with type-1 DM have low circulating levels of 25(OH) D. These patients have poor glycemic control (56.06%) than those with sufficient levels of 25(OH) D. Fokl polymorphism of VDR gene is associated with vitamin D deficiency but has no significant role in susceptibility to type-1 diabetes.	Vitamin D	236-245	vitamin D receptor	Homo sapiens	208-211
23001465-7	2013	The CYP24A1 gene mutation leads to the increased sensitivity of the patients to even prophylactic doses of vitamin D and to the development of severe symptomatic hypercalcemia in patients with IIH.	Vitamin D	107-116	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	4-11
27669215-13	2016	In summary, the results suggested that the lower the distribution of vitamin D concentration, the more the genetic variations in CYP24A1, VDR and GC genes may be associated with NSCLC risk.	Vitamin D	69-78	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	129-136
27669215-13	2016	In summary, the results suggested that the lower the distribution of vitamin D concentration, the more the genetic variations in CYP24A1, VDR and GC genes may be associated with NSCLC risk.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	138-141
27632366-1	2016	The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species.	Vitamin D	82-91	cytochrome P450 family 24 subfamily A member 1	Canis lupus familiaris	193-200
24081327-1	2013	BACKGROUND/AIMS: Vitamin D regulates gene transcription by binding to the vitamin D receptor (VDR), potentially affecting cardiometabolic disease risk.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	74-92
24081327-1	2013	BACKGROUND/AIMS: Vitamin D regulates gene transcription by binding to the vitamin D receptor (VDR), potentially affecting cardiometabolic disease risk.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	94-97
27595605-1	2016	BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
23690671-2	2013	Indeed, vitamin D and analogue molecules, besides the classical actions on bone metabolism, exert several beneficial effects on metabolic homeostasis, heart-cardiovascular, brain, and muscle physiological functions, throughout the interaction with the specific vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D receptor	Homo sapiens	261-279
27595605-2	2016	Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis.	Vitamin D	76-85	vitamin D receptor	Homo sapiens	42-45
23690671-2	2013	Indeed, vitamin D and analogue molecules, besides the classical actions on bone metabolism, exert several beneficial effects on metabolic homeostasis, heart-cardiovascular, brain, and muscle physiological functions, throughout the interaction with the specific vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D receptor	Homo sapiens	281-284
23942553-4	2013	Recently, this view has been challenged by the observation that fibroblast growth factor-23 (FGF23), a newly discovered hormone produced in the bone that regulates phosphate and vitamin D metabolism by the kidney, is a strong predictor of adverse cardiovascular outcomes in patients with CKD and ESRD.	Vitamin D	178-187	fibroblast growth factor 23	Homo sapiens	64-91
28497083-1	2017	Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis.	Vitamin D	175-184	fibroblast growth factor 23	Homo sapiens	27-54
23942553-4	2013	Recently, this view has been challenged by the observation that fibroblast growth factor-23 (FGF23), a newly discovered hormone produced in the bone that regulates phosphate and vitamin D metabolism by the kidney, is a strong predictor of adverse cardiovascular outcomes in patients with CKD and ESRD.	Vitamin D	178-187	fibroblast growth factor 23	Homo sapiens	93-98
28497083-1	2017	Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis.	Vitamin D	175-184	fibroblast growth factor 23	Homo sapiens	56-61
24099173-7	2013	The effects of EB1089 on SGC-7901 SP cells were blocked by treating cells with vitamin D receceptor (VDR) siRNA or butin (an inhibitor of the mitochondrial apoptosis pathway).	Vitamin D	79-88	vitamin D receptor	Homo sapiens	101-104
27222384-7	2016	Vitamin D receptor gene silencing blocked this synergistic effect of vitamin D and TGFbeta1 on both collagen production and myofibroblast differentiation.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	0-18
27217488-3	2016	Given the importance of the brain in controlling both glucose levels and body weight, we hypothesized that activation of central VDR links vitamin D to the regulation of glucose and energy homeostasis.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	129-132
27217488-4	2016	Indeed, we found that small doses of active vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3) (calcitriol), into the third ventricle of the brain improved glucose tolerance and markedly increased hepatic insulin sensitivity, an effect that is dependent upon VDR within the paraventricular nucleus of the hypothalamus.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	258-261
23744412-5	2013	The neuroprotective effect of vitamin D is associated with its influence on neurotrophin production and release, neuromediator synthesis, intracellular calcium homeostasis, and prevention of oxidative damage to nervous tissue.	Vitamin D	30-39	brain derived neurotrophic factor	Homo sapiens	76-88
27829825-0	2016	Matrix Metalloproteinase (MMP)-9 Levels in Children on Hemodialysis: Association with MMP-9 C-1562T Gene Polymorphism and Vitamin D Levels.	Vitamin D	122-131	matrix metallopeptidase 9	Homo sapiens	0-32
27570856-11	2016	CONCLUSION: The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	62-65
27571093-7	2016	Interestingly, a significant correlation between 25(OH) vitamin D and TPO-Ab (r = -0.27, p = 0.03) and FT3 (r = 0.35, p = 0.006) has been found in subjects with AT while no correlation was found between 25(OH) vitamin D levels and TG-Ab (r = -0.15, p = 0.25), TSH (r = -0.014, p = 0.09) and FT4 (r = 0.13, p = 0.32).	Vitamin D	56-65	thyroid peroxidase	Homo sapiens	70-73
23041230-1	2012	20-Hydroxyvitamin D(3) (20(OH)D(3)), the major product of CYP11A1 action on vitamin D(3), is biologically active and is produced in vivo.	Vitamin D	10-19	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	58-65
27345382-12	2016	Further investigations of the VDR and its relationship with PD are required to identify the role of vitamin D in the pathogenesis of PD.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	30-33
27579147-7	2016	Bioinformatic analysis revealed multiple candidate genes for both PTH and vitamin D, including CUBN, MGAT3, and NFKBIA.	Vitamin D	74-83	cubilin	Homo sapiens	95-99
22921424-10	2012	Speculations about the vitamin D usage in prevention or therapy of cardiovascular disease need to take potential drawbacks of vitamin D overdosing into account: Vitamin D overdosing might induce hypercalcemia, hyperphosphatemia, and increases in fibroblast growth-factor 23.	Vitamin D	23-32	fibroblast growth factor 23	Homo sapiens	246-273
28164608-2	2016	Vitamin D has antitumor functions in the body; any changes in VDR expression can therefore affect the anticancer activities of Vitamin D.	Vitamin D	127-136	vitamin D receptor	Homo sapiens	62-65
27125758-0	2016	Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	92-95
22921424-10	2012	Speculations about the vitamin D usage in prevention or therapy of cardiovascular disease need to take potential drawbacks of vitamin D overdosing into account: Vitamin D overdosing might induce hypercalcemia, hyperphosphatemia, and increases in fibroblast growth-factor 23.	Vitamin D	161-170	fibroblast growth factor 23	Homo sapiens	246-273
27125758-0	2016	Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects.	Vitamin D	169-178	vitamin D receptor	Homo sapiens	92-95
27125758-1	2016	This study aimed to evaluate the relationship between the cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	129-132
23128575-5	2012	RECENT FINDINGS: The precise spectrum of vitamin D activities can now be better evaluated by critical analysis of mouse models with targeted deletion of the gene encoding the vitamin D receptor (VDR).	Vitamin D	41-50	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	175-193
32699567-3	2016	In this study, we characterize the effects of vitamin D-deficiency and sufficiency on the cutaneous expression of TREM-1, TREM-2, VDR, HMGB1, and RAGE.	Vitamin D	46-55	triggering receptor expressed on myeloid cells 1	Sus scrofa	114-120
32699567-6	2016	In vitamin D-sufficient animals, keratinocytes exhibited elevated levels of TREM-1, TREM-2.	Vitamin D	3-12	triggering receptor expressed on myeloid cells 1	Sus scrofa	76-82
22358381-9	2012	The study demonstrates that vitamin D is effective on Th1/Th2 balance in patients with allergic rhinitis and that there is a significant relation between vitamin D deficiency and allergy.	Vitamin D	28-37	negative elongation factor complex member C/D	Homo sapiens	54-57
22848110-4	2012	Recently, a phosphaturic hormone, the fibroblast growth factor-23 (FGF-23), has been reported as a key regulator of P and vitamin D metabolism.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	38-65
27128845-0	2016	Molecular assessment of vitamin D receptor polymorphism as a valid predictor to the response of interferon/ribavirin-based therapy in Egyptian patients with chronic hepatitis C. OBJECTIVE: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR).	Vitamin D	24-33	vitamin D receptor	Homo sapiens	283-301
27128845-0	2016	Molecular assessment of vitamin D receptor polymorphism as a valid predictor to the response of interferon/ribavirin-based therapy in Egyptian patients with chronic hepatitis C. OBJECTIVE: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR).	Vitamin D	24-33	vitamin D receptor	Homo sapiens	303-306
27358421-1	2016	BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	73-91
22848110-4	2012	Recently, a phosphaturic hormone, the fibroblast growth factor-23 (FGF-23), has been reported as a key regulator of P and vitamin D metabolism.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	67-73
27358421-1	2016	BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	93-96
22848110-6	2012	The elevated FGF-23 levels result in a negative P balance to maintain P homeostasis, inducing phosphaturia, independently of PTH, and suppressing vitamin D synthesis.	Vitamin D	146-155	fibroblast growth factor 23	Homo sapiens	13-19
23206285-2	2012	The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	229-247
23206285-2	2012	The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	249-252
26325246-10	2016	There were weak negative correlations with length and C-3 epimer of 25(OH)D. CONCLUSIONS: In contrast to our hypothesis, gross motor achievements were significantly higher in infants receiving 400 IU/day vitamin D.	Vitamin D	204-213	complement C3	Homo sapiens	54-57
23112173-10	2012	Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D.	Vitamin D	145-154	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
23155244-0	2012	Marked increase of CYP24A1 mRNA level in hepatocellular carcinoma cell lines following vitamin D administration.	Vitamin D	87-96	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	19-26
27785354-3	2016	The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	73-91
27785354-3	2016	The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	93-96
27392908-1	2016	BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before.	Vitamin D	12-21	defensin beta 4B	Homo sapiens	102-117
27392908-1	2016	BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before.	Vitamin D	26-35	defensin beta 4B	Homo sapiens	102-117
27512288-1	2016	[Purpose] The effects of vitamin D on the circulating levels of IL-17 and IL-13 were investigated in patients with diabetic peripheral neuropathy, patients with diabetes mellitus type 2 without neuropathy, and healthy controls.	Vitamin D	25-34	interleukin 17A	Homo sapiens	64-69
27512288-10	2016	[Conclusion] Vitamin D is a potential modifiable risk factor for diabetic peripheral neuropathy and may regulate inflammatory mediators, e.g., IL-17 and IL-13.	Vitamin D	13-22	interleukin 17A	Homo sapiens	143-148
22923289-12	2012	However, in the FF polymorphism of the VDR gene group, vitamin D supplementation may retard the higher rate of bone loss.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	39-42
26928188-1	2016	UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D.	Vitamin D	136-145	fibroblast growth factor 23	Homo sapiens	69-96
26928188-1	2016	UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D.	Vitamin D	136-145	fibroblast growth factor 23	Homo sapiens	98-103
22610885-1	2012	Vitamin D binding protein (GC) gene polymorphisms are known to influence vitamin D levels.	Vitamin D	73-82	GC vitamin D binding protein	Homo sapiens	0-25
27309378-1	2016	BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	126-144
27309378-1	2016	BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	146-149
22927052-5	2012	Upon infection, intracellular levels of DeltaphoPQ, DeltapmrAB, and PhoP(c) S. Typhi decreased over time but were not further inhibited by the vitamin D(3)-induced increase in camp expression.	Vitamin D	143-152	cathelicidin antimicrobial peptide	Mus musculus	176-180
27203211-1	2016	The relationship between age, vitamin D status, expression and functionality of the vitamin D receptor (VDR), and key genes in the vitamin D pathway in immune cells is unclear.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	104-107
22612324-1	2012	BACKGROUND: Genetic polymorphisms of vitamin D receptor gene (VDR) and genes involved in vitamin D metabolism pathway, CYP27B1 and CYP24B1, may affect individual susceptibility to oral squamous cell carcinoma.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	62-65
27230841-4	2016	FGF23 is a hormone secreted from osteocytes and osteoblasts and acts on renal tubular cells to promote phosphate excretion into the urine and suppress synthesis of active form of vitamin D (1,25-dihydroxyvitamin D3;1,25(OH)(2)D(3)).	Vitamin D	179-188	fibroblast growth factor 23	Mus musculus	0-5
23128114-3	2012	Their characterization of the underlying mechanisms provides new understanding of how kidney disease impairs the health benefits of vitamin D-FGF23/klotho interactions.	Vitamin D	132-141	fibroblast growth factor 23	Homo sapiens	142-147
27489574-3	2016	However, the various U-shaped associations for allergic reactions may be due to vitamin D modulation of the phenotype of the immune response, shifting the Th1-Th2 balance toward Th2 formation.	Vitamin D	80-89	negative elongation factor complex member C/D	Homo sapiens	155-158
27160686-1	2016	BACKGROUND: Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibility to active tuberculosis (TB) in the UK, but this phenomenon has not been investigated in settings with a high TB burden.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	97-100
27160686-1	2016	BACKGROUND: Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibility to active tuberculosis (TB) in the UK, but this phenomenon has not been investigated in settings with a high TB burden.	Vitamin D	77-86	GC vitamin D binding protein	Homo sapiens	110-135
23128114-3	2012	Their characterization of the underlying mechanisms provides new understanding of how kidney disease impairs the health benefits of vitamin D-FGF23/klotho interactions.	Vitamin D	132-141	klotho	Homo sapiens	148-154
22930691-1	2012	Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalacia.	Vitamin D	256-265	fibroblast growth factor 23	Mus musculus	183-216
23075451-2	2012	Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells.	Vitamin D	71-80	negative elongation factor complex member C/D	Homo sapiens	133-136
27127116-1	2016	BACKGROUND: The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)).	Vitamin D	16-25	vitamin D receptor	Homo sapiens	127-145
27127116-1	2016	BACKGROUND: The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)).	Vitamin D	16-25	vitamin D receptor	Homo sapiens	147-150
26983959-9	2016	Serum vitamin D levels were negatively correlated with VDBP-Ab levels in patients in whom T1D developed during the winter.	Vitamin D	6-15	GC vitamin D binding protein	Homo sapiens	55-59
26152509-2	2016	1alpha,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ], the biologically active metabolite of vitamin D, is a critical modulator of immune response via binding with vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	156-174
26152509-2	2016	1alpha,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ], the biologically active metabolite of vitamin D, is a critical modulator of immune response via binding with vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	176-179
26152509-10	2016	In conclusion, decreased expression of VDR might contribute to the hyperimmune status of AA and appropriate vitamin D supplementation could partly correct the immune dysfunction by strengthening signal transduction through VDR in patients with AA.	Vitamin D	108-117	vitamin D receptor	Homo sapiens	223-226
26307135-8	2016	Lower levels of intact FGF23 with recent use of tenofovir, efavirenz or lopinavir may reflect their adverse effects on bone and vitamin D metabolism relative to other drugs in their respective drug classes.	Vitamin D	128-137	fibroblast growth factor 23	Homo sapiens	23-28
27196318-1	2016	PURPOSE: Our previous studies show that human corneal epithelial cells (HCEC) have a functional vitamin D receptor (VDR) and respond to vitamin D by dampening TLR-induced inflammation.	Vitamin D	96-105	vitamin D receptor	Homo sapiens	116-119
26906744-7	2016	Vitamin D deficiency did not alter muscle mass but reduced muscle force over time, downregulated vitamin D receptor expression, and increased muscle lipid peroxidation but did not alter actin and myosin expression, fiber dimensions or twitch relaxation time.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-115
26907966-3	2016	The vitamin D receptor (VDR) is expressed in epithelial cells of the normal thyroid gland, as well as in malignant dividing cells, which respond to the active metabolite of vitamin D by decreased proliferative activity in vitro.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
26907966-7	2016	There was a high ExR of VDR between Ca/N thyroid tissue from the same patient (3.06+-2.9), which also exhibited a high Ca/N ExR of ECM1 and/or of TMPRSS4 (&gt;2, P=0.05).The finding that increased VDR expression in human thyroid cancer cells is often linked to increased ECM1 and/or TPMRSS4 expression warrants further investigation into the potential role of vitamin D analogs in thyroid carcinoma.	Vitamin D	360-369	vitamin D receptor	Homo sapiens	24-27
27032111-13	2016	The patients with optimal vitamin D status [25(OH)D &gt;=75 nmol/l] had lower plasma levels of CCL7 (P = 0.047) and basic fibroblast growth factor (P = 0.042).	Vitamin D	26-35	C-C motif chemokine ligand 7	Homo sapiens	95-99
26887953-0	2016	Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis.	Vitamin D	108-117	7-dehydrocholesterol reductase	Homo sapiens	36-66
26887953-9	2016	Thus, these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis.	Vitamin D	95-104	7-dehydrocholesterol reductase	Homo sapiens	31-36
23075451-6	2012	Vitamin D was well tolerated and induced a preferential increase of naive CD4+ T cells, an increase of regulatory T cells and a decrease of effector Th1 and Th17 cells.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	149-152
22791341-10	2012	The VDR ligand calcitriol reversed the VDR loss and inhibited EMT in the mouse UUO model, and late administration of active vitamin D was effective in restoring VDR expression as well, and reduced collagen accumulation and deposition compared with the vehicle control.	Vitamin D	124-133	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	39-42
27123490-0	2016	DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient.	Vitamin D	64-73	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	16-23
27123490-10	2016	Our data demonstrate that the association between genetic variations in CACNA1C and PD depends on vitamin D deficiency, providing one potential mechanism underlying the association between vitamin D deficiency and PD.	Vitamin D	98-107	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	72-79
27123490-10	2016	Our data demonstrate that the association between genetic variations in CACNA1C and PD depends on vitamin D deficiency, providing one potential mechanism underlying the association between vitamin D deficiency and PD.	Vitamin D	189-198	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	72-79
27053850-10	2016	Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients (r = 0.38, P &lt; 0.05) and with patient age (r = 0.54, P &lt; 0.01).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	74-77
22791341-10	2012	The VDR ligand calcitriol reversed the VDR loss and inhibited EMT in the mouse UUO model, and late administration of active vitamin D was effective in restoring VDR expression as well, and reduced collagen accumulation and deposition compared with the vehicle control.	Vitamin D	124-133	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	39-42
27053850-11	2016	CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	72-75
22791341-11	2012	beta-Catenin expression induced by UUO was also significantly inhibited after the late administration of vitamin D.	Vitamin D	105-114	catenin (cadherin associated protein), beta 1	Mus musculus	0-12
22871339-0	2012	Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	46-50
26335302-0	2016	Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis.	Vitamin D	0-9	sirtuin 1	Homo sapiens	106-111
23246677-1	2012	Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	0-18
26704532-4	2016	The 25-hydroxylation involves mainly CYP2R1 and CYP27A1, whereas 1alpha-hydroxylation and 24-hydroxylation are catalyzed by CYP27B1 and CYP24A1, respectively, and are tightly regulated to maintain adequate levels of the active vitamin D hormone, 1alpha,25(OH)2D3.	Vitamin D	227-236	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	136-143
23246677-1	2012	Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	20-23
26704532-8	2016	We found that these cells express mRNAs for the four major CYP450 enzymes involved in vitamin D activation and inactivation, and vitamin D receptor (VDR) that mediates vitamin D actions.	Vitamin D	129-138	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	149-152
22692397-2	2012	Numerous genes have been linked to the emergence of SLE, including vitamin D receptor (VDR) gene that synthesizes the receptor of vitamin D.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	87-90
26943962-0	2016	Immunomodulation by vitamin D in multiple sclerosis: More than IL-17.	Vitamin D	20-29	interleukin 17A	Homo sapiens	63-68
22692397-4	2012	Vitamin D"s biological functions are mediated by VDR.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	49-52
22878961-1	2012	Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23).	Vitamin D	166-175	klotho	Mus musculus	6-12
26423691-9	2016	In addition, the finding that the VDR polymorphism TaqI was associated with myopathy may indicate a causal relationship between vitamin D function and myopathy, but larger studies are needed before firm conclusions can be drawn.	Vitamin D	128-137	vitamin D receptor	Homo sapiens	34-37
26910045-3	2016	The results demonstrate that Vitamin D significantly inhibited the abilities of T lymphocytes to produce IFN-gamma and proliferate in vitro (P&lt;=0.05), but retained their ability to undergo degranulation, which is a maker for cytotoxicity of these cells.	Vitamin D	29-38	interferon gamma	Gallus gallus	105-114
26304030-3	2016	CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPalpha) transcription factors.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	58-61
26813507-1	2016	FGF23-related hypophosphatemic rickets is basically treated with active vitamin D and phosphorus.	Vitamin D	72-81	fibroblast growth factor 23	Homo sapiens	0-5
26287968-1	2016	Although fibroblast growth factor (FGF) 23 was recently identified as a phosphatonin that influences vitamin D metabolism, the underlying signaling mechanisms remain unclear.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	35-38
26643910-0	2016	Thyroid hormone and vitamin D regulate VGF expression and promoter activity.	Vitamin D	20-29	VGF nerve growth factor inducible	Homo sapiens	39-42
26643910-6	2016	In silico studies identified possible thyroid and vitamin D response elements in the VGF promoter.	Vitamin D	50-59	VGF nerve growth factor inducible	Homo sapiens	85-88
26751954-1	2016	BACKGROUND: Vitamin-D-binding protein (VDBP) is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH) vitamin D 3/VDBP complex.	Vitamin D	132-141	GC vitamin D binding protein	Homo sapiens	39-43
26751954-1	2016	BACKGROUND: Vitamin-D-binding protein (VDBP) is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH) vitamin D 3/VDBP complex.	Vitamin D	132-141	GC vitamin D binding protein	Homo sapiens	144-148
26654942-9	2016	Studies employing VDR siRNA, CYP27B1 zinc finger nucleases, and pharmacologic inhibitors of the vitamin D pathway indicate that 25D3 regulates gene expression in a VDR-dependent manner but does not strictly require 1alphaOHase-mediated conversion of 25D3 to 1,25D3.	Vitamin D	96-105	vitamin D receptor	Homo sapiens	164-167
26479950-1	2016	The discovery of vitamin D receptor (VDR) expression in immune cells has opened up a new area of research into immunoregulation by vitamin D, a niche that is distinct from its classical role in skeletal health.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
25738688-13	2016	The VDR genotype might become more relevant when clustered in a specific haplotype, associated with other SNPs of genes involved in vitamin D metabolism, or for specific tumors and/or patient characteristics.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	4-7
26853300-2	2016	Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D &lt; 50 nmol/L) in more than half of all athletes and military personnel tested during the winter, when skin sunlight UVB is negligible.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	25-43
26853300-2	2016	Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D &lt; 50 nmol/L) in more than half of all athletes and military personnel tested during the winter, when skin sunlight UVB is negligible.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	25-43
26943610-5	2016	VDR is often co-localized with its metabolizing enzymes, suggesting the importance of tissue specific modulation of active vitamin D levels.	Vitamin D	123-132	vitamin D receptor	Homo sapiens	0-3
26943634-2	2016	We aimed to explore the effects of vitamin D supplementation on serum FGF23 and to elucidate longitudinal changes in FGF23, in addition to studying its association with mineral metabolism in early infancy.	Vitamin D	35-44	fibroblast growth factor 23	Homo sapiens	70-75
26069294-2	2016	However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways.	Vitamin D	9-18	fibroblast growth factor 23	Homo sapiens	130-159
26069294-2	2016	However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways.	Vitamin D	9-18	fibroblast growth factor 23	Homo sapiens	161-167
26069294-2	2016	However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways.	Vitamin D	9-18	klotho	Homo sapiens	169-175
26235988-1	2016	Fibroblast growth factor-23 (Fgf23) is a bone-derived hormone, suppressing phosphate reabsorption and vitamin D hormone (1,25(OH)2 D3 ) production in the kidney.	Vitamin D	102-111	fibroblast growth factor 23	Mus musculus	0-27
26235988-1	2016	Fibroblast growth factor-23 (Fgf23) is a bone-derived hormone, suppressing phosphate reabsorption and vitamin D hormone (1,25(OH)2 D3 ) production in the kidney.	Vitamin D	102-111	fibroblast growth factor 23	Mus musculus	29-34
27713770-9	2016	Discussion:Altered levels of Vit D affect the balance between LL-37, IL-8 and SAA, suggesting an association with AAU, an extra-articular manifestation of AS.	Vitamin D	29-34	serum amyloid A1 cluster	Homo sapiens	78-81
26681795-6	2016	Although the identification of mechanisms mediating VDR-regulated transcription has been one focus of recent research in the field, other topics of fundamental importance include the identification and functional significance of proteins involved in the metabolism of vitamin D.	Vitamin D	268-277	vitamin D receptor	Homo sapiens	52-55
26827947-3	2016	Current studies are now refocused on the vitamin D hormone"s action at the genome, where VDR together with other transcription factors coordinates the recruitment of chromatin active coregulatory complexes that participate directly in the modification of gene output.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	89-92
26827947-8	2016	These studies advance our understanding of not only vitamin D action but also of the complex and dynamic role played by the genome itself as a major determinant of VDR activity.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	164-167
26827949-8	2016	Additionally, we describe the crystal structures of VDR mutants associated with hereditary vitamin D-resistant rickets that display impaired ligand-binding function.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	52-55
26827951-1	2016	One of the most pronounced effects of the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is increased synthesis of 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1), the enzyme responsible for the catabolism of 1,25(OH)2D3.	Vitamin D	68-77	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	182-189
26827953-1	2016	1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	114-132
26827953-1	2016	1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	134-137
27125741-3	2016	The discovery of KL as a partner for FGF23 led to significant advances in understanding of the molecular mechanisms underlying phosphate and vitamin D metabolism, and simultaneously clarified the pathogenic roles of the FGF23 signaling pathway in human diseases.	Vitamin D	141-150	klotho	Homo sapiens	17-19
22878961-1	2012	Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23).	Vitamin D	166-175	fibroblast growth factor 23	Mus musculus	195-222
27125741-3	2016	The discovery of KL as a partner for FGF23 led to significant advances in understanding of the molecular mechanisms underlying phosphate and vitamin D metabolism, and simultaneously clarified the pathogenic roles of the FGF23 signaling pathway in human diseases.	Vitamin D	141-150	fibroblast growth factor 23	Homo sapiens	37-42
27125741-4	2016	These novel insights led to the development of new strategies to combat disorders associated with the dysregulated metabolism of phosphate and vitamin D, and clinical trials on the blockade of FGF23 signaling in X-linked hypophosphatemic rickets are ongoing.	Vitamin D	143-152	fibroblast growth factor 23	Homo sapiens	193-198
22878961-1	2012	Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23).	Vitamin D	166-175	fibroblast growth factor 23	Mus musculus	224-229
27081473-4	2015	There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH).	Vitamin D	59-68	fibroblast growth factor 23	Homo sapiens	40-45
22855339-1	2012	CONTEXT: Inherited forms of vitamin D deficiency are rare causes of rickets and to date have been traced to mutations in three genes, VDR, encoding the 1alpha,25-dihydroxyvitamin D receptor, CYP27B1, encoding the vitamin D 1alpha-hydroxylase, and CYP2R1, encoding a microsomal vitamin D 25-hydroxylase.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	134-137
22807503-6	2012	The pathogenesis of CKD-MBD is incompletely understood but has recently been redefined with the emergence of fibroblast growth factor 23 (FGF-23) as a major influence on control of vitamin D and parathyroid hormone.	Vitamin D	181-190	fibroblast growth factor 23	Homo sapiens	109-136
26644513-5	2015	Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation.	Vitamin D	127-136	vitamin D receptor	Homo sapiens	115-118
26340892-9	2015	Vitamin D-deficient mice also showed increases in myostatin and the atrophy marker E3-ubiqutin ligase MuRF1.	Vitamin D	0-9	tripartite motif-containing 63	Mus musculus	102-107
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	interleukin 17A	Homo sapiens	265-269
26416604-6	2015	The T allele (vitamin-D-increasing allele) of DHCR7 rs12785878 was associated with greater decreases in insulin and HOMA-IR (p &lt; 0.002) in response to high-protein diets, while there was no significant genotype effect on changes in these traits in the low-protein diet group.	Vitamin D	14-23	7-dehydrocholesterol reductase	Homo sapiens	46-51
22807503-6	2012	The pathogenesis of CKD-MBD is incompletely understood but has recently been redefined with the emergence of fibroblast growth factor 23 (FGF-23) as a major influence on control of vitamin D and parathyroid hormone.	Vitamin D	181-190	fibroblast growth factor 23	Homo sapiens	138-144
22801440-2	2012	The active form of vitamin D interacts with its receptor the VDR that is expressed in multiple tissues and it is involved in platelets (PLTs) function.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	61-64
26441239-0	2015	A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice.	Vitamin D	87-96	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	45-48
27141540-1	2015	BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	126-144
22801440-9	2012	CONCLUSION: The lower VDR expression in osteoporotic could indicate a lower ability to respond to vitamin D, and could be the explanation of the increase in the PTH and decrease in the phosphorus levels in patients with respect to controls.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	22-25
22648952-10	2012	We found that expression of VDR and CYP27B1 increased significantly at day 7 of regeneration, and these results confirm the expression of Vdr and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury.	Vitamin D	195-204	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	28-31
29391997-1	2015	Objective: With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1alpha,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-gamma), which are important for immune response of patients with allergic rhinitis.	Vitamin D	116-125	negative elongation factor complex member C/D	Homo sapiens	71-74
22595971-10	2012	These findings provide relevant insights into how vitamin D influences the immune system and the risk of MS through VDR interactions with the chromatin state inside MS regions.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	116-119
29391997-7	2015	Conclusion: In our study, 1alpha,25-dihydroxyvitamin D3 levels were associated with Th1/Th2 balance in allergic rhinitis, and a remarkable correlation was observed among vitamin D deficiency and allergy.	Vitamin D	45-54	negative elongation factor complex member C/D	Homo sapiens	84-87
26346470-0	2015	Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	0-18
22879719-7	2012	In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog.	Vitamin D	156-165	vitamin D receptor	Homo sapiens	55-58
26346470-0	2015	Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial.	Vitamin D	66-75	caudal type homeobox 2	Homo sapiens	19-24
26346470-1	2015	This study aimed to investigate the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on central obesity indicators in subjects with type 2 diabetes (T2D) and the possible modulation of this effect by vitamin D receptor (VDR) Cdx-2 genotypes.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	219-237
26346470-1	2015	This study aimed to investigate the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on central obesity indicators in subjects with type 2 diabetes (T2D) and the possible modulation of this effect by vitamin D receptor (VDR) Cdx-2 genotypes.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	239-242
26346470-1	2015	This study aimed to investigate the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on central obesity indicators in subjects with type 2 diabetes (T2D) and the possible modulation of this effect by vitamin D receptor (VDR) Cdx-2 genotypes.	Vitamin D	63-72	caudal type homeobox 2	Homo sapiens	244-249
22700885-1	2012	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 plays an important role in regulating phosphate and vitamin D homeostasis.	Vitamin D	107-116	fibroblast growth factor 23	Homo sapiens	27-54
26346470-7	2015	Daily intake of vitamin D-FD for 12 weeks improved the central obesity indices in T2D subjects, and the improvement was more pronounced in the carriers of the AA genotype of VDR-Cdx-2.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	174-177
26346470-7	2015	Daily intake of vitamin D-FD for 12 weeks improved the central obesity indices in T2D subjects, and the improvement was more pronounced in the carriers of the AA genotype of VDR-Cdx-2.	Vitamin D	16-25	caudal type homeobox 2	Homo sapiens	178-183
26566277-9	2015	Together, our data indicates two different models of experimental kidney failure comparably associate with disturbed FGF23-alphaklotho-vitamin-D signalling and a deregulated electrolyte homeostasis.	Vitamin D	134-144	fibroblast growth factor 23	Mus musculus	117-122
22404291-0	2012	Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality.	Vitamin D	18-27	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	48-55
26228633-2	2015	Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D, and rosuvastatin.	Vitamin D	215-224	heat shock protein family A (Hsp70) member 4	Homo sapiens	53-58
26503876-1	2015	FGF23 produced mainly by osteocytes plays a central role in phosphate homeostasis by increasing the renal phosphate excretion and suppressing the vitamin D activation.	Vitamin D	146-155	fibroblast growth factor 23	Homo sapiens	0-5
22404291-1	2012	Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	69-80
22404291-1	2012	Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	82-85
22339716-2	2012	The present study aimed to evaluate vitamin D status and its relation to Th1/Th2 balance in subjects with T1D, their siblings and unrelated healthy controls during autumn and winter 2008-2009.	Vitamin D	36-45	negative elongation factor complex member C/D	Homo sapiens	73-76
26731879-6	2015	Both were found to have a loss-of-function mutation in the CYP24A1 gene, which encodes the vitamin D-metabolizing enzyme 25-hydroxyvitamin D 24-hydroxylase.	Vitamin D	91-100	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	59-66
22703926-13	2012	CONCLUSIONS: FGF-23, a hormone involved in phosphorous and vitamin D homeostasis, is independently associated with all-cause death and incident HF in community-living older persons.	Vitamin D	59-68	fibroblast growth factor 23	Homo sapiens	13-19
22801813-0	2012	The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children.	Vitamin D	51-60	7-dehydrocholesterol reductase	Homo sapiens	19-24
26257123-1	2015	Vitamin D has a pivotal role in regulating immune responses by promoting Th2 immune responses and suppressing Th1 responses.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	110-113
22801813-3	2012	Our objective was to identify the relationship among three vitamin D-related genes (GC, CYP2R1 and DHCR7/NADSYN1) and the levels of 25(OH)D in northeastern Han Chinese children.	Vitamin D	59-68	7-dehydrocholesterol reductase	Homo sapiens	99-104
22801813-3	2012	Our objective was to identify the relationship among three vitamin D-related genes (GC, CYP2R1 and DHCR7/NADSYN1) and the levels of 25(OH)D in northeastern Han Chinese children.	Vitamin D	59-68	NAD synthetase 1	Homo sapiens	105-112
22085499-2	2012	The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
26224799-2	2015	Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
22085499-7	2012	Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	8-11
22484315-1	2012	Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	118-136
26722516-0	2015	Alterations in vitamin D signaling pathway in gastric cancer progression: a study of vitamin D receptor expression in human normal, premalignant, and malignant gastric tissue.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	85-103
22484315-1	2012	Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	138-141
23467804-3	2012	This concept is strongly supported by several independent studies in genetically modified mice (including FGF23(-/-) and Klotho(-/-) mice) that are characterized by altered mineral homeostasis caused by a high vitamin D activity.	Vitamin D	210-219	fibroblast growth factor 23	Mus musculus	106-111
26214117-13	2015	We confirm the accuracy and effectiveness of a novel blood test estimating the ratio between relevant vitamin D metabolites as a useful screening tool for CYP24A1 mutations.	Vitamin D	102-111	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	155-162
22699377-1	2012	Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action.	Vitamin D	18-27	GC vitamin D binding protein	Homo sapiens	127-152
22474172-8	2012	This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays.	Vitamin D	150-159	vitamin D receptor	Homo sapiens	5-8
26210580-2	2015	Its genomic actions are mediated via the active form of vitamin D, 1,25(OH)2D3, binding to the vitamin D receptor (VDR).	Vitamin D	56-65	vitamin D receptor	Homo sapiens	95-113
22474172-8	2012	This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays.	Vitamin D	150-159	retinoid X receptor alpha	Homo sapiens	66-74
26210580-2	2015	Its genomic actions are mediated via the active form of vitamin D, 1,25(OH)2D3, binding to the vitamin D receptor (VDR).	Vitamin D	56-65	vitamin D receptor	Homo sapiens	115-118
22474172-8	2012	This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays.	Vitamin D	150-159	vitamin D receptor	Homo sapiens	62-65
26210580-16	2015	This study has, for the first time, shown that vitamin D directly modulates TH expression and strongly suggests N-cadherin may be a plausible mediator of this process both in vitro and in vivo.	Vitamin D	47-56	cadherin 2	Homo sapiens	112-122
26298324-0	2015	Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	34-37
22474172-11	2012	We showed that expression of the SLCO1A2 gene is induced by vitamin D(3) at the transcriptional level through the VDR.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	114-117
22690899-0	2012	Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma.	Vitamin D	9-18	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	51-58
26298324-0	2015	Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease.	Vitamin D	0-9	CD4 antigen	Mus musculus	49-52
26504744-3	2015	Recent studies connected the gene encoding for vitamin D (VDR) to the genetic control of bone mass and other diseases.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	58-61
22690899-10	2012	How deficient 25(OH)D(3) levels in combination with certain CYP24A1 haplotypes affect vitamin D activation is the subject of future studies.	Vitamin D	86-95	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-67
26697339-1	2015	The effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	50-68
26697339-1	2015	The effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	70-73
22681928-0	2012	Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	108-126
26697339-2	2015	VDR and the retinoid X receptor (RXR) form a dimer complex which binds to genomic vitamin D responsive elements located primarily in promoter regions and recruit cell-specific transcription factor complexes which regulate the expression of numerous genes.	Vitamin D	82-91	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
25911112-1	2015	Serum vitamin D is bound to vitamin D-binding protein (DBP).	Vitamin D	6-15	D-box binding PAR bZIP transcription factor	Rattus norvegicus	55-58
25911112-10	2015	Moreover, DBP is required for vitamin D-induced attenuation of HG-induced renin in NRK-49F cells.	Vitamin D	30-39	D-box binding PAR bZIP transcription factor	Rattus norvegicus	10-13
26198928-0	2015	Effect of high dose vitamin D intake on interleukin-17 levels in multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial.	Vitamin D	20-29	interleukin 17A	Homo sapiens	40-54
26198928-4	2015	OBJECTIVE: This study assessed the effect of oral high dose vitamin D intake on IL-17 levels in MS patients in a double blind randomized clinical trial.	Vitamin D	60-69	interleukin 17A	Homo sapiens	80-85
26206427-1	2015	Continuing the structure-activity relationship studies in the vitamin D area, we designed and synthesized novel C-9 substituted calcitriol analogues, possessing different nonpolar groups at this position.	Vitamin D	62-71	complement C9	Homo sapiens	112-115
26037400-0	2015	Vitamin D levels in multiple sclerosis patients: Association with TGF-beta2, TGF-betaRI, and TGF-betaRII expression.	Vitamin D	0-9	transforming growth factor beta 2	Homo sapiens	66-75
26037400-3	2015	Here, we aim to study whether vitamin D affects TGF-beta pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients.	Vitamin D	30-39	transforming growth factor beta 2	Homo sapiens	48-56
26037400-8	2015	SIGNIFICANCE: Here, we demonstrate new evidence for the complex role of vitamin D in the pathogenesis, activity and progression of MS through the TGF-beta signaling pathway.	Vitamin D	72-81	transforming growth factor beta 2	Homo sapiens	146-154
26025591-8	2015	The presence of vitamin D receptor (VDR) and the enzyme responsible for conversion of the 25(OH)D in its active metabolite 25(OH)2D3 in extra renal tissue shows the involvement of vitamin D in other diseases like cancer, diabetes, multiple sclerosis etc.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
25837735-6	2015	From this holistic viewpoint, we offer new insights into an old debate: whether vitamin D"s effects in the musculoskeletal system are direct via local VDR signals or indirect via its systemic effects in calcium and phosphate homeostasis.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	151-154
25934099-9	2015	KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease.	Vitamin D	88-97	klotho	Homo sapiens	0-6
25934099-9	2015	KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	7-34
25934099-9	2015	KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	36-41
25707738-2	2015	Vitamin D has immune modulatory effects on T cells through the nuclear vitamin D receptor (VDR) in vitro.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	71-89
25707738-2	2015	Vitamin D has immune modulatory effects on T cells through the nuclear vitamin D receptor (VDR) in vitro.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-94
25707738-4	2015	The aim of this study was to establish a flow cytometry protocol, including nuclear and cytoplasmic VDR expression, and to investigate the effects of vitamin D treatment on T cell VDR expression in CD patients.	Vitamin D	150-159	vitamin D receptor	Homo sapiens	180-183
25707738-12	2015	This VDR up-regulation was inhibited with 30% by vitamin D treatment compared to placebo in CD patients (P = 0027).	Vitamin D	49-58	vitamin D receptor	Homo sapiens	5-8
25707738-15	2015	Vitamin D treatment in CD patients reduces T cell receptor-mediated VDR up-regulation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	68-71
26119311-4	2015	The VDR functions in a largely 1alpha,25 (OH) (2)D(3)-controlled manner by interacting directly with vitamin D response elements located within regulatory regions that are linked to cell-specific target genes.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	4-7
22681928-3	2012	We determined the prevalence of vitamin D deficiency in girls from South Brazil and investigated whether the genotypic distribution of the BsmI, ApaI and TaqI polymorphisms of the VDR gene and their haplotypes were associated with vitamin D levels.	Vitamin D	231-240	vitamin D receptor	Homo sapiens	180-183
22681928-14	2012	The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	45-48
22681928-14	2012	The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	146-149
22681928-14	2012	The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents.	Vitamin D	213-222	vitamin D receptor	Homo sapiens	45-48
22672495-4	2012	Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	23-41
22304841-0	2012	Vitamin D and insulin sensitivity: can gene association and pharmacogenetic studies of the vitamin D receptor provide clarity?	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-109
22523113-1	2012	The discovery of fibroblast growth factor-23 (FGF-23) as a key regulator of phosphate and vitamin D metabolism has forced a rethink about the mineral and bone disorder of chronic kidney disease (CKD).	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	17-44
22523113-1	2012	The discovery of fibroblast growth factor-23 (FGF-23) as a key regulator of phosphate and vitamin D metabolism has forced a rethink about the mineral and bone disorder of chronic kidney disease (CKD).	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	46-52
22523113-3	2012	Nevertheless, despite the known action of active vitamin D therapies to increase FGF-23, this should probably still form an important part of the management of patients with hyperparathyroidism and perhaps at low doses of essentially all patients with advanced renal disease.	Vitamin D	49-58	fibroblast growth factor 23	Homo sapiens	81-87
22563729-2	2012	The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interactions.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	79-82
22563729-2	2012	The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interactions.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	115-118
26252259-2	2015	Vitamin D functions are not limited to the regulation of bone; it plays many pleiotropic effects due to ubiquitous distribution of VDR (Vitamin D Receptor).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	131-134
22421513-1	2012	FGF23 is a bone-derived hormone that regulates systemic phosphate homeostasis, vitamin D metabolism and alpha-Klotho expression through a novel bone-kidney axis.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	0-5
26252259-2	2015	Vitamin D functions are not limited to the regulation of bone; it plays many pleiotropic effects due to ubiquitous distribution of VDR (Vitamin D Receptor).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	136-154
25873553-3	2015	This pilot study explores if vitamin D supplementation could reduce serum concentrations of inflammatory cytokines (interleukin [IL] 6, IL-10, tumor necrosis factor alpha), adiponectin, lipids, hemoglobin A1C, and high-sensitivity C-reactive protein (hs-CRP).	Vitamin D	29-38	interleukin 10	Homo sapiens	136-141
23214203-4	2012	FGF-23 with a coreceptor (Klotho protein) inhibits renal phosphate reabsorption and synthesis of calcitriol by reducing 1alpha-hydroxylase (CYP27B1) activity, reducing vitamin D-dependent phosphate intestinal absorption.	Vitamin D	168-177	fibroblast growth factor 23	Homo sapiens	0-6
26403394-5	2015	Vitamin D binds its receptor VDR, resulting in transcription of a number of genes playing a role in inhibition of MAPK.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	29-32
23214203-4	2012	FGF-23 with a coreceptor (Klotho protein) inhibits renal phosphate reabsorption and synthesis of calcitriol by reducing 1alpha-hydroxylase (CYP27B1) activity, reducing vitamin D-dependent phosphate intestinal absorption.	Vitamin D	168-177	klotho	Homo sapiens	26-32
26347327-6	2015	Fibroblast growth factor23 (FGF23) is a bone-derived hormone that plays an important role in the regulation of phosphate and vitamin D metabolism.	Vitamin D	125-134	fibroblast growth factor 23	Homo sapiens	0-26
22041016-3	2012	We elucidated the immunolocalization of vitamin D receptor (VDR) and the effects of vitamin D(3) (VD(3)) on mouse periodontal fibroblasts to clarify the role of VDR and VD(3) in the differentiation of periodontal fibroblasts.	Vitamin D	40-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	60-63
26347327-6	2015	Fibroblast growth factor23 (FGF23) is a bone-derived hormone that plays an important role in the regulation of phosphate and vitamin D metabolism.	Vitamin D	125-134	fibroblast growth factor 23	Homo sapiens	28-33
25716068-3	2015	The placenta as an important source of vitamin D regulates its metabolism through the vitamin D receptor (VDR), but the mechanism by which VDR regulates trophoblast function is poorly understood.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	86-104
22247037-1	2012	Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms.	Vitamin D	56-65	fibroblast growth factor 23	Homo sapiens	0-27
25716068-3	2015	The placenta as an important source of vitamin D regulates its metabolism through the vitamin D receptor (VDR), but the mechanism by which VDR regulates trophoblast function is poorly understood.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	106-109
22247037-1	2012	Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms.	Vitamin D	56-65	fibroblast growth factor 23	Homo sapiens	29-34
25661837-2	2015	One such environmental factor is vitamin D, a vital hormone that plays a specific function in the immune system homeostasis, acting through a nuclear receptor (VDR) expressed in all immune cells.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	160-163
22311183-7	2012	Plasma levels of alpha-1 antitrypsin isotypes 2-5, apolipoprotein A-IV, and vitamin D-binding protein isotypes 1 and 2 were significantly reduced in BRCA1 mutation carriers with respect to non-mutant controls.	Vitamin D	76-85	BRCA1 DNA repair associated	Homo sapiens	149-154
26005021-2	2015	Signaling of vitamin D is mediated via its ubiquitously expressed nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	88-106
26005021-2	2015	Signaling of vitamin D is mediated via its ubiquitously expressed nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	108-111
22025115-8	2012	RRF, serum phosphorus and calcium levels and active vitamin D therapy explain 69% of the variation in FGF-23.	Vitamin D	52-61	fibroblast growth factor 23	Homo sapiens	102-108
21390563-1	2012	Fibroblast growth factor 23 (FGF23) is a novel hormone produced by bone with known functions to regulate urinary phosphate excretion, as well as vitamin D and PTH production.	Vitamin D	145-154	fibroblast growth factor 23	Homo sapiens	0-27
25904071-0	2015	The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions.	Vitamin D	4-13	CD8a molecule	Homo sapiens	61-64
25904071-0	2015	The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions.	Vitamin D	4-13	interleukin 17A	Homo sapiens	66-71
25904071-11	2015	Our findings show that the vitamin D analogue calcipotriol reduces the frequency of CD8(+) IL-17(+) T cells in psoriasis lesions concomitant with clinical improvement.	Vitamin D	27-36	CD8a molecule	Homo sapiens	84-87
25904071-11	2015	Our findings show that the vitamin D analogue calcipotriol reduces the frequency of CD8(+) IL-17(+) T cells in psoriasis lesions concomitant with clinical improvement.	Vitamin D	27-36	interleukin 17A	Homo sapiens	91-96
26105695-1	2015	Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	97-115
26105695-1	2015	Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	117-120
25940599-9	2015	The positive correlation of VDBP levels and placental transporter expression suggests that delivery of vitamin D to the placenta may be important.	Vitamin D	103-112	GC vitamin D binding protein	Homo sapiens	28-32
26107738-0	2015	Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells.	Vitamin D	0-9	interleukin 22	Homo sapiens	96-101
26107738-3	2015	Moreover, whether vitamin D treatment of DCs regulates their ability to promote differentiation of IL-17-/IL-22-producing T cell subsets, such as Th17 and Th22 cell, is not known.	Vitamin D	18-27	interleukin 17A	Homo sapiens	99-104
26107738-3	2015	Moreover, whether vitamin D treatment of DCs regulates their ability to promote differentiation of IL-17-/IL-22-producing T cell subsets, such as Th17 and Th22 cell, is not known.	Vitamin D	18-27	interleukin 22	Homo sapiens	106-111
26107738-5	2015	Cytokines secreted by vitamin D-treated DC were significantly more potent in driving differentiation of IL-22-producing T cells, but not IL-17-producing T cells, as compared to secreted cytokines of not-vitamin D-treated DCs.	Vitamin D	22-31	interleukin 22	Homo sapiens	104-109
26107738-6	2015	Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23.	Vitamin D	98-107	interleukin 22	Homo sapiens	46-51
25326845-0	2015	Vitamin D prevents the intestinal fibrosis via induction of vitamin D receptor and inhibition of transforming growth factor-beta1/Smad3 pathway.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	60-78
25326845-12	2015	CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction.	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	221-224
25326845-12	2015	CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction.	Vitamin D	77-86	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	221-224
25237033-1	2015	Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	198-216
25237033-1	2015	Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	218-221
25237033-1	2015	Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	328-331
25445919-6	2015	In MCF10DCIS cells treated with vitamin D compounds (1alpha25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced.	Vitamin D	32-41	CD44 molecule (Indian blood group)	Homo sapiens	145-149
25445919-6	2015	In MCF10DCIS cells treated with vitamin D compounds (1alpha25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced.	Vitamin D	32-41	integrin subunit alpha 6	Homo sapiens	169-174
25446885-0	2015	Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass.	Vitamin D	15-24	sclerostin	Mus musculus	107-117
25447737-1	2015	The active form of vitamin D (1alpha,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	138-156
25447737-1	2015	The active form of vitamin D (1alpha,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	158-161
25447737-2	2015	Recent deep sequencing analysis of VDR binding locations across the complete genome has significantly expanded our understanding of the actions of vitamin D and VDR on gene transcription.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	35-38
25447737-9	2015	hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	45-48
25447737-9	2015	hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	122-125
25448743-1	2015	Topical 1,25-dihydroxyvitamin D (1,25D) and other vitamin D compounds have been shown to protect skin from damage by ultraviolet radiation (UVR) in a process that requires the vitamin D receptor.	Vitamin D	22-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	176-194
25448744-12	2015	Of importance in the observation is that several regulatory effects are deranged in the presence of hyperglycemia, particularly the PTH- and vitamin D-dependent up regulation of VDR and 1OHase in these cells.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	178-181
25500070-9	2015	Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect.	Vitamin D	146-155	actin-binding Rho activating protein	Rattus norvegicus	64-68
25500070-9	2015	Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect.	Vitamin D	146-155	fatty acid binding protein 2	Rattus norvegicus	77-82
25541438-0	2015	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.	Vitamin D	57-66	CD44 molecule (Indian blood group)	Homo sapiens	93-97
25541438-3	2015	We previously reported that a Gemini vitamin D analog, 1,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluoro-cholecalciferol (BXL0124), reduced CD44(+)/CD24(-/low) cells in MCF10DCIS basal-like breast cancer cells.	Vitamin D	37-46	CD44 molecule (Indian blood group)	Homo sapiens	185-189
25576905-0	2015	VDR FokI polymorphism is associated with a reduced T-helper cell population under vitamin D stimulation in type 1 diabetes patients.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	0-3
25576905-2	2015	Additionally, the immune system regulator vitamin D, exerts its modulatory effects through the vitamin D receptor (VDR) expressed in Th cells.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	95-113
25576905-2	2015	Additionally, the immune system regulator vitamin D, exerts its modulatory effects through the vitamin D receptor (VDR) expressed in Th cells.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	115-118
25597951-8	2015	VDR mRNA and protein levels were lower (-65% and -90%) in the colon of CAC; APC(Delta580/Delta580) mice compared to control mice, suggesting loss of colon responsiveness to vitamin D.	Vitamin D	173-182	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
25603468-7	2015	Consistently, colonic epithelial VDR levels are markedly reduced in patients with inflammatory bowel diseases or in experimental colitis models, whereas vitamin D analog therapy that ameliorates colitis up-regulates epithelial VDR.	Vitamin D	153-162	vitamin D receptor	Homo sapiens	227-230
25376135-3	2015	Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	33-51
25376135-3	2015	Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	53-56
25376135-3	2015	Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	120-123
26338395-3	2015	New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus.	Vitamin D	122-131	klotho	Homo sapiens	55-61
26338395-3	2015	New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	66-93
26338395-3	2015	New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	95-101
21390563-1	2012	Fibroblast growth factor 23 (FGF23) is a novel hormone produced by bone with known functions to regulate urinary phosphate excretion, as well as vitamin D and PTH production.	Vitamin D	145-154	fibroblast growth factor 23	Homo sapiens	29-34
22387385-3	2012	In this work, the effect of vitamin D treatment on dengue virus infection in human hepatic Huh-7 cells and on virus infection and cytokine production in the human monocytic U937 cells was evaluated.	Vitamin D	28-37	MIR7-3 host gene	Homo sapiens	91-96
22294750-1	2012	It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis.	Vitamin D	216-225	fibroblast growth factor 23	Mus musculus	59-86
22294750-1	2012	It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis.	Vitamin D	216-225	fibroblast growth factor 23	Mus musculus	88-93
22449247-1	2012	INTRODUCTION: In the past years, the biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormone and its nuclear receptor, the transcription factor vitamin D receptor (VDR).	Vitamin D	65-74	vitamin D receptor	Homo sapiens	271-289
22449247-1	2012	INTRODUCTION: In the past years, the biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormone and its nuclear receptor, the transcription factor vitamin D receptor (VDR).	Vitamin D	65-74	vitamin D receptor	Homo sapiens	291-294
22130326-5	2012	The second SNP, rs12785878, is located near DHCR7 (Chr11), a genetic determinant of vitamin D insufficiency, and showed a size effect in MS similar to that recently observed in Type 1 diabetes (T1D; OR = 1.10; P = 0.009).	Vitamin D	84-93	7-dehydrocholesterol reductase	Homo sapiens	44-49
22322599-5	2012	The protective effects of 1,25-(OH)(2)D(3) against thymine dimers were abolished in fibroblasts from patients with hereditary vitamin D-resistant rickets that expressed no VDR protein, indicating that the VDR is essential for photoprotection.	Vitamin D	126-135	vitamin D receptor	Homo sapiens	205-208
22322599-6	2012	Photoprotection remained in hereditary vitamin D-resistant rickets fibroblasts expressing a VDR with a defective DNA-binding domain or a mutation in helix H1 of the classical ligand-binding domain, both defects resulting in a failure to mediate genomic responses, implicating nongenomic responses for photoprotection.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	92-95
22370611-0	2012	Vitamin D deficiency is associated with increased IL-17 and TNFalpha levels in patients with chronic heart failure.	Vitamin D	0-9	interleukin 17A	Homo sapiens	50-55
23814529-2	2012	Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	0-18
23814529-2	2012	Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	20-23
22393163-7	2012	Chromatin immunoprecipitation (ChIP) assay revealed, for the first time, the presence of two vitamin D response elements (VDREs) in the FGF23 promoter.	Vitamin D	93-102	fibroblast growth factor 23	Homo sapiens	136-141
22301548-8	2012	Moreover, in BMM from MKP1(-/-) mice, the inhibition of LPS-induced p38 phosphorylation by vitamin D was completely abolished.	Vitamin D	91-100	dual specificity phosphatase 1	Mus musculus	22-26
22301548-9	2012	Vitamin D inhibition of LPS-induced IL-6 and TNF-alpha production by BMM from MKP-1(-/-) mice was significantly reduced as compared with wild-type mice.	Vitamin D	0-9	dual specificity phosphatase 1	Mus musculus	78-83
26889405-6	2012	VDR activation using newer agents including vitamin D mimetics (such as paricalcitol and maxacalcitol) are promising agents, which may be related to their selectivity in activating VDR by means of attracting different post-D-complex cofactors.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	0-3
26889405-6	2012	VDR activation using newer agents including vitamin D mimetics (such as paricalcitol and maxacalcitol) are promising agents, which may be related to their selectivity in activating VDR by means of attracting different post-D-complex cofactors.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	181-184
22382217-13	2012	We conclude that the serum levels of vitamin D are lower in children with ESRD than in age-matched controls, and that it is significantly positively related to the anti-inflammatory IL-10 and negatively related to the pro-inflammatory SIL-2R.	Vitamin D	37-46	interleukin 10	Homo sapiens	182-187
25815722-0	2015	Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kB signaling pathways.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	84-102
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	7-dehydrocholesterol reductase	Homo sapiens	44-49
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	59-62
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	73-80
25799011-3	2015	We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma.	Vitamin D	15-24	retinoid X receptor alpha	Homo sapiens	91-95
25784096-0	2015	Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis (EAE).	Vitamin D	0-9	interleukin 27	Mus musculus	38-43
25784096-0	2015	Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis (EAE).	Vitamin D	0-9	interleukin 33	Mus musculus	48-53
25784096-2	2015	OBJECTIVE: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE).	Vitamin D	38-47	interleukin 27	Mus musculus	69-74
25784096-2	2015	OBJECTIVE: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE).	Vitamin D	38-47	interleukin 33	Mus musculus	79-84
25784096-9	2015	In vitamin D-treated EAE group, the expression of IL-27 P28 and IL-27 EBI3 were significantly higher compared with the olive oil-treated EAE groups (p&lt;0.002 and p&lt;0.04, respectively).	Vitamin D	3-12	interleukin 27	Mus musculus	50-55
22079836-7	2012	The two vitamin D dependent cell types are the iNKT cells and CD4/CD8alphaalpha intraepithelial lymphocytes (IEL).	Vitamin D	8-17	CD4 antigen	Mus musculus	62-65
25784096-9	2015	In vitamin D-treated EAE group, the expression of IL-27 P28 and IL-27 EBI3 were significantly higher compared with the olive oil-treated EAE groups (p&lt;0.002 and p&lt;0.04, respectively).	Vitamin D	3-12	interleukin 27	Mus musculus	64-69
25784096-11	2015	Vitamin D significantly decreased the expression of IL-33 compared with PBS- or olive oil-treated EAE mice (p&lt;0.04, p&lt;0.02, respectively).	Vitamin D	0-9	interleukin 33	Mus musculus	52-57
24620922-11	2015	CONCLUSIONS: In community-dwelling elderly individuals with highly prevalent vitamin D deficiency, FGF-23 levels were associated with LV hypertrophy and predicted mortality independently of two robust cardiac biomarkers.	Vitamin D	77-86	fibroblast growth factor 23	Homo sapiens	99-105
21730210-1	2012	BACKGROUND: Elevated fibroblast growth factor 23 (FGF23) is associated with adverse clinical outcomes and development of secondary hyperparathyroidism (SHPT) refractory to active vitamin D.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	21-48
26528423-5	2015	Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism.	Vitamin D	222-231	klotho	Mus musculus	9-15
26528423-5	2015	Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism.	Vitamin D	222-231	fibroblast growth factor 23	Mus musculus	63-66
26528423-5	2015	Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism.	Vitamin D	222-231	fibroblast growth factor 23	Mus musculus	122-127
25448751-14	2015	Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
25294851-8	2015	Importantly, in rat SHPT, the correction of vitamin D deficiency effectively reversed the resistance to paricalcitol induction of C/EBPbeta to suppress ADAM17 expression and PTG enlargement, reducing PTH by 50%.	Vitamin D	44-53	CCAAT/enhancer binding protein beta	Rattus norvegicus	130-139
25294851-9	2015	CONCLUSION: In SHPT, correction of vitamin D and calcitriol deficiency induces parathyroid C/EBPbeta to efficaciously attenuate the severe ADAM17/TGFalpha synergy, which drives PTG enlargement and high PTH.	Vitamin D	35-44	ADAM metallopeptidase domain 17	Homo sapiens	139-145
25324357-2	2015	In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia and vitamin D receptor (VDR) loss, hence restoring the response to vitamin D.	Vitamin D	146-155	epidermal growth factor receptor	Rattus norvegicus	32-64
25324357-2	2015	In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia and vitamin D receptor (VDR) loss, hence restoring the response to vitamin D.	Vitamin D	146-155	epidermal growth factor receptor	Rattus norvegicus	66-70
25366373-0	2015	Associations between the levels of sclerostin, phosphate, and fibroblast growth factor-23 and treatment with vitamin D in hemodialysis patients with low intact PTH level.	Vitamin D	109-118	fibroblast growth factor 23	Homo sapiens	62-89
25028176-11	2015	This could be due to low maternal vitamin D levels in patients with GDM because in vitro low calcitriol doses upregulate VDR in trophoblast cells.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	121-124
25542806-2	2015	Recently, variants of vitamin D metabolizing genes, including rs12368653, rs10876994, rs118204009 and rs703842 in CYP27B1, and rs2248359 in CYP24A1 have been identified to be associated with the pathogenicity of MS in Caucasian populations.	Vitamin D	22-31	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	140-147
25519225-7	2015	Mechanistic studies indicated that the selective toxicity of miR-17~92 polycistron inactivation was the consequence of derepression of vitamin D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1alpha,25-dihydroxyvitamin D3 metabolic pathway.	Vitamin D	135-144	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	174-181
25887475-1	2015	BACKGROUND: The vitamin D receptor (VDR) mediates the major cellular activities of vitamin D and regulates various signaling pathways implicated in cancer development and progression.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
25667505-9	2015	First results suggest that both the number of genome-wide VDR binding sites and the expression of VDR target genes correlate with vitamin D status of the studied human individuals.	Vitamin D	130-139	vitamin D receptor	Homo sapiens	58-61
25667505-9	2015	First results suggest that both the number of genome-wide VDR binding sites and the expression of VDR target genes correlate with vitamin D status of the studied human individuals.	Vitamin D	130-139	vitamin D receptor	Homo sapiens	98-101
25421379-9	2015	CONCLUSION: Breast cancer risk may be associated with specific vitamin D-related polymorphisms, particularly CYP24A1.	Vitamin D	63-72	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	109-116
24803230-2	2015	Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	55-73
24803230-2	2015	Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	75-78
25510482-6	2015	Altogether, vitamin D-deficient TB patients expressed a weak antimicrobial response but an IL-21 associated expansion of IgG-secreting B cells combined with a rise in FoxP3(+) regulatory T cells at the local site of infection.	Vitamin D	12-21	interleukin 21	Homo sapiens	91-96
25461390-7	2015	Supplemental vitamin D increased interferon (IFN)-gamma and interleukin (IL)-10 in subjects that were vitamin D insufficient (serum 25(OH)D&lt;29ng/mL) compared to sufficient (serum 25(OH)D&gt;=30ng/mL) at Bsl.	Vitamin D	13-22	interleukin 10	Homo sapiens	60-79
25407646-5	2015	Vitamin D mediates its effect through binding to vitamin D receptor (VDR), which is harbored on many human immune cells, and in this way is able to modulate immune cells activity, triggering both innate and adaptive immune responses.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	49-67
25407646-5	2015	Vitamin D mediates its effect through binding to vitamin D receptor (VDR), which is harbored on many human immune cells, and in this way is able to modulate immune cells activity, triggering both innate and adaptive immune responses.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	69-72
25407646-6	2015	As VDR gene polymorphisms were found to associate with AITD, the evidence links vitamin D deficiency to AITD either through gene polymorphism or by environmental factors (lack of dietary uptake and sun exposure).	Vitamin D	80-89	vitamin D receptor	Homo sapiens	3-6
25375986-1	2015	CONTEXT: Mutations of the CYP24A1 gene encoding the 24-hydroxylase (24OHase) that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults; in vitro assays of 24OHase activity have been difficult.	Vitamin D	109-118	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	26-33
25375986-1	2015	CONTEXT: Mutations of the CYP24A1 gene encoding the 24-hydroxylase (24OHase) that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults; in vitro assays of 24OHase activity have been difficult.	Vitamin D	109-118	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	68-75
25375986-1	2015	CONTEXT: Mutations of the CYP24A1 gene encoding the 24-hydroxylase (24OHase) that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults; in vitro assays of 24OHase activity have been difficult.	Vitamin D	109-118	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	185-192
25375986-2	2015	OBJECTIVE: We sought an alternative assay to characterize a CYP24A1 mutation in a young adult with bilateral nephrolithiasis and hypercalcemia associated with ingestion of excess vitamin D supplements and robust dairy intake for 5 years.	Vitamin D	179-188	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-67
25375986-10	2015	Heterozygous mutation of CYP24A1 may cause hypercalcemia in the setting of excessive vitamin D intake, but it is also possible that the patient had another, unidentified CYP24A1 mutation on the other allele.	Vitamin D	85-94	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	25-32
25581929-0	2015	Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study.	Vitamin D	0-9	MROS	Homo sapiens	78-82
25451947-0	2015	Serum free 1,25-dihydroxy-vitamin D is more closely associated with fibroblast growth factor 23 than other vitamin D forms in chronic dialysis patients.	Vitamin D	26-35	fibroblast growth factor 23	Homo sapiens	68-95
25451947-2	2015	However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population.	Vitamin D	49-58	fibroblast growth factor 23	Homo sapiens	63-90
25451947-2	2015	However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population.	Vitamin D	49-58	fibroblast growth factor 23	Homo sapiens	92-98
25451947-10	2015	CONCLUSION: The relationship between FGF-23 and vitamin D is stronger using free forms of 25-OH-D and 1,25-(OH)2-D.	Vitamin D	48-57	fibroblast growth factor 23	Homo sapiens	37-43
26693712-1	2015	BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D.	Vitamin D	136-145	fibroblast growth factor 23	Homo sapiens	12-39
26693712-1	2015	BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D.	Vitamin D	136-145	fibroblast growth factor 23	Homo sapiens	41-46
21730210-1	2012	BACKGROUND: Elevated fibroblast growth factor 23 (FGF23) is associated with adverse clinical outcomes and development of secondary hyperparathyroidism (SHPT) refractory to active vitamin D.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	50-55
22227726-6	2012	Zip code of residence was used to evaluate potential for skin production of vitamin D.	Vitamin D	76-85	death associated protein kinase 3	Homo sapiens	0-3
26064917-1	2015	OBJECTIVE: This study was designed to evaluate vitamin D status with separate determination of 25-OH D2 and 25-OH D3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD).	Vitamin D	47-56	GC vitamin D binding protein	Homo sapiens	141-166
26064917-1	2015	OBJECTIVE: This study was designed to evaluate vitamin D status with separate determination of 25-OH D2 and 25-OH D3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD).	Vitamin D	47-56	GC vitamin D binding protein	Homo sapiens	168-172
27536382-11	2015	Chronic ethanol consumption also resulted in tissue increases of vitamin D response (VDR) protein, Cyp2E1, and reductions in vitamin D-activating enzyme CYP27B1.	Vitamin D	65-74	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	85-88
22249518-0	2012	Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism.	Vitamin D	53-62	fibroblast growth factor 23	Homo sapiens	22-28
22249518-1	2012	The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of hereditary hypophosphatemic and hyperphosphatemic disorders, as well as acquired disorders of phosphate metabolism, such as chronic kidney disease.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	17-44
22249518-1	2012	The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of hereditary hypophosphatemic and hyperphosphatemic disorders, as well as acquired disorders of phosphate metabolism, such as chronic kidney disease.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	46-52
25344836-0	2015	Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions.	Vitamin D	0-9	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	47-51
22249518-5	2012	These FGF-23 regulatory pathways may enable systemic phosphate and vitamin D homeostasis to be coordinated with bone mineralization.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	6-12
25344836-2	2015	Surprisingly, these Lgr5+ stem cell properties were abrogated by the lower dietary vitamin D and calcium in a semi-purified diet that promotes both genetically initiated and sporadic intestinal tumors.	Vitamin D	83-92	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	20-24
25344836-5	2015	Therefore, vitamin D, a common nutrient and inducer of intestinal cell maturation, is an environmental factor that is a determinant of Lgr5+ stem cell functions in vivo.	Vitamin D	11-20	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	135-139
22396160-4	2012	FGF23 is secreted from bone and acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis.	Vitamin D	85-94	fibroblast growth factor 23	Homo sapiens	0-5
26152633-5	2015	Vitamin D in airway epithelium decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and IP-10.	Vitamin D	0-9	C-X-C motif chemokine ligand 10	Homo sapiens	102-107
22396161-1	2012	Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and circulating phosphate and possibly PTH.	Vitamin D	146-155	fibroblast growth factor 23	Homo sapiens	0-27
26023015-5	2015	FGF23, in cooperation with Klotho, inhibits phosphate reabsorption and vitamin D production at the kidney.	Vitamin D	71-80	fibroblast growth factor 23	Homo sapiens	0-5
26023015-5	2015	FGF23, in cooperation with Klotho, inhibits phosphate reabsorption and vitamin D production at the kidney.	Vitamin D	71-80	klotho	Homo sapiens	27-33
22396161-1	2012	Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and circulating phosphate and possibly PTH.	Vitamin D	146-155	fibroblast growth factor 23	Homo sapiens	29-34
22396162-0	2012	Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis.	Vitamin D	111-120	fibroblast growth factor 23	Homo sapiens	13-18
25483861-0	2015	Double point modified analogs of vitamin d as potent activators of vitamin D receptor.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	67-85
25396269-8	2015	Our data indicate that out of the variants in 29 different genes analyzed, variants of 11 genes, including EXOC2, TYR, and TYRP1, have the highest impact on vitamin D status.	Vitamin D	157-166	tyrosinase	Homo sapiens	114-117
22396162-3	2012	In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess.	Vitamin D	201-210	fibroblast growth factor 23	Homo sapiens	13-18
22396162-3	2012	In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess.	Vitamin D	201-210	fibroblast growth factor 23	Homo sapiens	82-87
22396162-3	2012	In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess.	Vitamin D	201-210	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	98-103
22396163-2	2012	Vitamin D can induce both FGF23 and klotho synthesis to influence renal phosphate balance.	Vitamin D	0-9	fibroblast growth factor 23	Mus musculus	26-31
25664062-4	2014	Vitamin D exerts its action via the nuclear vitamin D receptor (VDR), which shows an extensive polymorphism.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	44-62
25664062-4	2014	Vitamin D exerts its action via the nuclear vitamin D receptor (VDR), which shows an extensive polymorphism.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	64-67
22396163-2	2012	Vitamin D can induce both FGF23 and klotho synthesis to influence renal phosphate balance.	Vitamin D	0-9	klotho	Mus musculus	36-42
22396163-6	2012	Vitamin D can induce the expression of both FGF23 and klotho while, FGF23 can suppress renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity.	Vitamin D	0-9	fibroblast growth factor 23	Mus musculus	44-49
22396163-6	2012	Vitamin D can induce the expression of both FGF23 and klotho while, FGF23 can suppress renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity.	Vitamin D	0-9	klotho	Mus musculus	54-60
25460500-8	2014	Furthermore, we show that in the presence of ligand, BRCA1 associates with vitamin D receptor (VDR) and the complex co-occupies vitamin D responsive elements (VDRE) at the CDKN1A (p21waf1) promoter and enhances acetylation of histone H3 and H4 at these sites.	Vitamin D	75-84	BRCA1 DNA repair associated	Homo sapiens	53-58
23183768-0	2012	Vitamin D analogs decrease in vitro secretion of RANTES and enhance the effect of budesonide.	Vitamin D	0-9	C-C motif chemokine ligand 5	Homo sapiens	49-55
25460500-8	2014	Furthermore, we show that in the presence of ligand, BRCA1 associates with vitamin D receptor (VDR) and the complex co-occupies vitamin D responsive elements (VDRE) at the CDKN1A (p21waf1) promoter and enhances acetylation of histone H3 and H4 at these sites.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	95-98
25290078-3	2014	Treatment of day 5 zebrafish larvae with inactive 25D (5-150 nM) or active 1,25D (0.1-10 nM) induced dose responsive expression (15-95-fold) of the vitamin D-target gene cyp24a1 relative to larvae treated with vehicle, suggesting the presence of Cyp27b1 activity.	Vitamin D	148-157	cytochrome P450, family 27, subfamily B, polypeptide 1	Danio rerio	246-253
25290078-7	2014	These data indicate that we have cloned a functional zebrafish CYP27B1, representing a phylogenetically distant branch from mammals of this key enzyme in vitamin D metabolism.	Vitamin D	154-163	cytochrome P450, family 27, subfamily B, polypeptide 1	Danio rerio	63-70
23183768-3	2012	The aim of this study was to assess the influence of vitamin D (VD) derivates on RANTES expression in the culture of nasal polyp fibroblasts.	Vitamin D	53-62	C-C motif chemokine ligand 5	Homo sapiens	81-87
22300961-10	2012	Analysing combined effects, a significant impact of low 25-OH vitamin D levels on sustained virological response were only seen in patients with the unfavourable NR1I1 CCA (bAt) haplotype (OR for non-SVR 3.55; 95% CI 1.005, 12.57; P=0.049).	Vitamin D	62-71	vitamin D receptor	Homo sapiens	162-167
25195132-1	2014	The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	107-125
22312480-5	2012	It is also proposed that deprivation of sunlight and vitamin D at higher latitudes facilitates the development of autoimmune diseases by aggravating the CD8+ T-cell deficiency and thereby further impairing control of EBV.	Vitamin D	53-62	CD8a molecule	Homo sapiens	153-156
25195132-1	2014	The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	127-130
25195132-1	2014	The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	127-130
25240094-3	2014	Flexible alignment and docking studies of the inhibitors in the CYP24A1 enzyme active site confirmed that complete occupation of the vitamin D access tunnel is essential to inhibitory activity, allowing exposure to multiple hydrophobic binding interactions and optimal conformation for the interaction of the imidazole nitrogen lone pair and the active site haem.	Vitamin D	133-142	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	64-71
22246283-1	2012	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	27-54
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	77-86	7-dehydrocholesterol reductase	Homo sapiens	291-296
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	77-86	NAD synthetase 1	Homo sapiens	297-304
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	345-354	7-dehydrocholesterol reductase	Homo sapiens	291-296
25405862-1	2014	BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese.	Vitamin D	345-354	NAD synthetase 1	Homo sapiens	297-304
22246283-1	2012	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	56-61
25414832-5	2014	In particular, genetic determinants innate to host intrinsic metabolic pathways such as highly polymorphic cytochromes P450s responsible for the metabolic activation of vitamin D are expressed in many organs, including the thyroid gland and can impact vitamin D interaction with its nuclear receptor (VDR) in thyroid tissue.	Vitamin D	169-178	vitamin D receptor	Homo sapiens	301-304
25414832-5	2014	In particular, genetic determinants innate to host intrinsic metabolic pathways such as highly polymorphic cytochromes P450s responsible for the metabolic activation of vitamin D are expressed in many organs, including the thyroid gland and can impact vitamin D interaction with its nuclear receptor (VDR) in thyroid tissue.	Vitamin D	252-261	vitamin D receptor	Homo sapiens	301-304
22785457-4	2012	In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	134-137
24688000-5	2014	Second, in 61 candidate SNPs involved in vitamin D metabolism and signaling, rs1507023 (in RBFOX1) and rs2296241 (in CYP24A1) showed significant associations with SBP, DBP, mean arterial pressure, or pulse pressure in the WGHS before, but not after, multiple testing corrections.	Vitamin D	41-50	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	retinoid X receptor alpha	Homo sapiens	159-163
22785457-4	2012	In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels.	Vitamin D	99-108	NAD synthetase 1	Homo sapiens	143-150
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	7-dehydrocholesterol reductase	Homo sapiens	176-181
22785457-4	2012	In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels.	Vitamin D	99-108	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	160-167
24688000-7	2014	Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	195-198
22785457-9	2012	Although this is a small study, our findings suggest that VDR, NADSYN1, and GC polymorphisms may be linked to the manifestation of vitamin D deficiency in Japanese children.	Vitamin D	131-140	vitamin D receptor	Homo sapiens	58-61
22785457-9	2012	Although this is a small study, our findings suggest that VDR, NADSYN1, and GC polymorphisms may be linked to the manifestation of vitamin D deficiency in Japanese children.	Vitamin D	131-140	NAD synthetase 1	Homo sapiens	63-70
25200615-1	2014	BACKGROUND: Fibroblast growth factor 23 (FGF23) is an important regulatory hormone in phosphate and vitamin D metabolism.	Vitamin D	100-109	fibroblast growth factor 23	Homo sapiens	12-39
25200615-1	2014	BACKGROUND: Fibroblast growth factor 23 (FGF23) is an important regulatory hormone in phosphate and vitamin D metabolism.	Vitamin D	100-109	fibroblast growth factor 23	Homo sapiens	41-46
22606047-0	2012	Fibroblast growth factor-23 helps explain the biphasic cardiovascular effects of vitamin D in chronic kidney disease.	Vitamin D	81-90	fibroblast growth factor 23	Homo sapiens	0-27
25771722-1	2014	The VDR gene is an important regulator of the vitamin D pathway, and the role of some of its polymorphisms on cancer risk was previously investigated.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	4-7
21958677-2	2012	Increased urinary loss of vitamin D binding protein (VDBP), the main transporter of 25-hydroxyvitamin D(3) in the circulation, has been postulated to contribute to vitamin D deficiency in proteinuria.	Vitamin D	26-35	GC vitamin D binding protein	Homo sapiens	53-57
25334067-11	2014	In conclusion, the local vitamin D endocrine system affects melanoma behavior and an elevated level of CYP24A1 appears to have an important impact on the formation of melanocytic nevi and melanomagenesis, or progression, at early stages of tumor development.	Vitamin D	25-34	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	103-110
25312721-0	2014	Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts.	Vitamin D	12-21	dickkopf WNT signaling pathway inhibitor 2	Homo sapiens	59-85
22108803-3	2012	VDR and RXR colocalized to predominantly promoter distal, vitamin D response element-containing sites in a largely ligand-dependent manner.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	0-3
29159099-5	2014	The vitamin D metabolite, 1,25-dihydroxyvitamin D3, has been demonstrated to markedly reduce cellular proliferation especially of malignant cells that have a vitamin D receptor.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	158-176
22108803-3	2012	VDR and RXR colocalized to predominantly promoter distal, vitamin D response element-containing sites in a largely ligand-dependent manner.	Vitamin D	58-67	retinoid X receptor alpha	Homo sapiens	8-11
23548800-2	2012	Vitamin D through its receptor, VDR, provides renal protection in diabetic nephropathy, but limited data exist about its effect on podocytes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	32-35
25339487-6	2014	Fibroblast Growth Factor 23, a bone-derived hormone that regulates vitamin D synthesis in renal proximal tubules and renal phosphate reabsorption, has been suggested to be the missing link between CKD and CVD.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	0-27
23185470-13	2012	VDBP and VDR polymorphisms, and low winter 25-OHD(3) serum concentrations may be risk factors for infectious diseases and chronic conditions related to the dysregulation of the vitamin D pathway.	Vitamin D	177-186	GC vitamin D binding protein	Homo sapiens	0-4
24937537-9	2014	RESULTS: Microarrays depicted 63 genes significantly regulated by 1,25(OH)2D3, including genes related to male androgen and vitamin D metabolism, mainly triggered by the vitamin D receptor/retinoid X receptor activation.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	170-188
22970174-2	2012	Efforts to identify gene products whose transcription is directly regulated by FGF23 stimulation of fibroblast growth factor receptors (FGFR)/alpha-Klotho complexes in the kidney is confounded by both systemic alterations in calcium, phosphorus and vitamin D metabolism and intrinsic alterations caused by the underlying renal pathology in CKD.	Vitamin D	249-258	fibroblast growth factor 23	Mus musculus	79-84
24937537-9	2014	RESULTS: Microarrays depicted 63 genes significantly regulated by 1,25(OH)2D3, including genes related to male androgen and vitamin D metabolism, mainly triggered by the vitamin D receptor/retinoid X receptor activation.	Vitamin D	124-133	retinoid X receptor alpha	Homo sapiens	189-208
24960544-0	2014	Activation of FGF-23 mediated vitamin D degradative pathways by cholecalciferol.	Vitamin D	30-39	fibroblast growth factor 23	Homo sapiens	14-20
24960544-11	2014	In addition, catabolism of 25(OH)D may also contribute to the low circulating vitamin D levels in CKD, since elevations of FGF-23 in CKD are associated with increased 24,25(OH)2D after cholecalciferol administration.	Vitamin D	78-87	fibroblast growth factor 23	Homo sapiens	123-129
22319626-0	2012	Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo.	Vitamin D	15-24	klotho	Mus musculus	0-6
24128439-0	2014	DNA methylation levels of CYP2R1 and CYP24A1 predict vitamin D response variation.	Vitamin D	53-62	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44
24128439-10	2014	For CYP24A1, baseline DNA methylation levels at two CpG sites were also negatively associated with vitamin D response variation (r=-0.151, P=0.011; r=-0.131, P=0.025).	Vitamin D	99-108	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	4-11
24128439-12	2014	Our findings indicate that baseline DNA methylation levels of CYP2R1 and CYP24A1 may predict vitamin D response variation.	Vitamin D	93-102	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	73-80
22871095-2	2012	Pancreatic tissues express the vitamin D receptor (VDR) and vitamin D-binding protein; some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose intolerance, defective insulin secretion, and sensitivity.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	51-54
22871095-2	2012	Pancreatic tissues express the vitamin D receptor (VDR) and vitamin D-binding protein; some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose intolerance, defective insulin secretion, and sensitivity.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	157-160
22000399-4	2011	Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR).	Vitamin D	69-78	vitamin D receptor	Homo sapiens	139-157
22000399-4	2011	Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR).	Vitamin D	69-78	vitamin D receptor	Homo sapiens	159-162
21664236-1	2011	The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing the enzymatic machinery to metabolize vitamin D to its active metabolite 1,25(OH)(2)D. Furthermore, these cells also express the vitamin D receptor (VDR) that enables them to respond to the 1,25(OH)(2)D they produce.	Vitamin D	161-170	vitamin D receptor	Homo sapiens	252-270
21664236-1	2011	The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing the enzymatic machinery to metabolize vitamin D to its active metabolite 1,25(OH)(2)D. Furthermore, these cells also express the vitamin D receptor (VDR) that enables them to respond to the 1,25(OH)(2)D they produce.	Vitamin D	161-170	vitamin D receptor	Homo sapiens	272-275
21664245-1	2011	The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1alpha,25(OH)(2)-vitamin D(3) [1alpha,25(OH)(2)D(3)], focusing on the role of the vitamin D receptor (VDR).	Vitamin D	145-154	vitamin D receptor	Homo sapiens	210-228
21664245-1	2011	The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1alpha,25(OH)(2)-vitamin D(3) [1alpha,25(OH)(2)D(3)], focusing on the role of the vitamin D receptor (VDR).	Vitamin D	145-154	vitamin D receptor	Homo sapiens	230-233
21664249-5	2011	The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR).	Vitamin D	61-70	vitamin D receptor	Homo sapiens	185-203
21664249-5	2011	The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR).	Vitamin D	61-70	vitamin D receptor	Homo sapiens	205-208
21664249-5	2011	The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR).	Vitamin D	155-164	vitamin D receptor	Homo sapiens	185-203
21664249-5	2011	The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR).	Vitamin D	155-164	vitamin D receptor	Homo sapiens	205-208
21664249-6	2011	Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1alpha-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites.	Vitamin D	14-23	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	181-186
21615392-12	2011	Ethnic background, sex, age, body weight and SNPs in CYP24A1 and PLCB1 were independent determinants of plasma vitamin D levels.	Vitamin D	111-120	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	53-60
21890490-0	2011	KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.	Vitamin D	46-55	lysine demethylase 6B	Homo sapiens	0-5
21890490-0	2011	KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.	Vitamin D	46-55	lysine demethylase 6B	Homo sapiens	6-11
21890490-2	2011	Here, we show that human JMJD3 expression is induced by the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and that JMJD3 modulates the gene regulatory action of this hormone.	Vitamin D	67-76	lysine demethylase 6B	Homo sapiens	25-30
21917910-1	2011	The vitamin D receptor (VDR) mediates vitamin D signaling in numerous physiological and pharmacological processes, including bone and calcium metabolism, cellular growth and differentiation, immunity, and cardiovascular function.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
21963453-1	2011	Previous research has shown that vitamin D could suppress proliferation, migration and invasion of cancers, but the effects of vitamin D may be related to the expression of Snail-1, which could inhibit the expression of the vitamin-D gene receptor (VDR).	Vitamin D	127-136	vitamin D receptor	Homo sapiens	224-247
21963453-1	2011	Previous research has shown that vitamin D could suppress proliferation, migration and invasion of cancers, but the effects of vitamin D may be related to the expression of Snail-1, which could inhibit the expression of the vitamin-D gene receptor (VDR).	Vitamin D	127-136	vitamin D receptor	Homo sapiens	249-252
21334752-6	2011	We found negative correlations between Hsp70 levels and micronutrients including vitamin D, vitamin B12, as well as folate, which could be linked to the immune modulating effects of these vitamins.	Vitamin D	81-90	heat shock protein family A (Hsp70) member 4	Homo sapiens	39-44
21682758-2	2011	This finding is of concern not only because of the classic vitamin D effects on musculoskeletal outcomes, but also because expression of the vitamin D receptor (VDR) and vitamin D metabolizing enzymes in the heart and blood vessels suggests a role of vitamin D in the cardiovascular system.	Vitamin D	141-150	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	161-164
21682758-2	2011	This finding is of concern not only because of the classic vitamin D effects on musculoskeletal outcomes, but also because expression of the vitamin D receptor (VDR) and vitamin D metabolizing enzymes in the heart and blood vessels suggests a role of vitamin D in the cardiovascular system.	Vitamin D	141-150	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	161-164
21682758-3	2011	VDR-knockout mice suffer from cardiovascular disease (CVD), and various experimental studies suggest cardiovascular protection by vitamin D, including antiatherosclerotic, anti-inflammatory and direct cardio-protective actions, beneficial effects on classic cardiovascular risk factors as well as suppression of parathyroid hormone (PTH) levels.	Vitamin D	130-139	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
21903990-6	2011	In adjusted analyses, absence of residual renal function and greater dialysis vintage associated with higher FGF23, independent of demographics, laboratory values, peritoneal dialysis modality and adequacy, and treatment with vitamin D analogs and phosphate binders.	Vitamin D	226-235	fibroblast growth factor 23	Homo sapiens	109-114
22011638-1	2011	Vitamin D is essential not only for calcium and bone metabolism, but it also may exert other biological activities, including immunomodulation through the expression of vitamin D receptor in antigen-presenting cells and activated T cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	169-187
21793032-5	2011	Treatment with vitamin D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin D metabolism and activity.	Vitamin D	15-24	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	102-109
21793032-5	2011	Treatment with vitamin D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin D metabolism and activity.	Vitamin D	170-179	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	102-109
21684333-1	2011	Variants of the vitamin D binding protein (VDBP) gene appear to be associated with levels of the main circulating vitamin D metabolite, 25-hydroxyvitamin D [(25(OH)D].	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	43-47
25090635-9	2014	Our data suggest that during ductal adenocarcinoma development the vitamin D system in the pancreas becomes deregulated on two levels: in the islets CYP24A1 expression decreases weakening the negative feedback regulation of the vitamin D-dependent insulin synthesis/secretion.	Vitamin D	67-76	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	149-156
25090635-10	2014	In the transformed ducts CYP24A1 expression increases, impairing the antiproliferative effect of vitamin D in these cells.	Vitamin D	97-106	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	25-32
21868377-11	2011	We conclude that Dex increases VDR and vitamin D effects by increasing Vdr de novo transcription in a GR-dependent manner.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	71-74
25132457-1	2014	The vitamin D endocrine system is functional in the adipose tissue, as demonstrated in vitro, in cultured adipocytes, and in vivo in mutant mice that developed altered lipid metabolism and fat storage in the absence of either 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] or the vitamin D receptor.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	272-290
21844098-2	2011	Here, we examined whether serum levels or genotypes of the vitamin D-binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder.	Vitamin D	59-68	GC vitamin D binding protein	Homo sapiens	86-90
21803771-8	2011	1,25(OH)(2)D(3) reversed high glucose-induced nephrin reduction in podocytes, and vitamin D analogs prevented nephrin decline in both type 1 and 2 diabetic mice.	Vitamin D	82-91	nephrosis 1, nephrin	Mus musculus	110-117
24975273-6	2014	CONCLUSION: We present a new approach to predict vitamin D target genes based on conserved genomic VDR-binding sites.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	99-102
24973411-2	2014	The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis.	Vitamin D	118-127	fibroblast growth factor 23	Homo sapiens	17-44
24973411-2	2014	The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis.	Vitamin D	118-127	fibroblast growth factor 23	Homo sapiens	46-51
24973411-3	2014	Through as yet undetermined mechanisms, circulating and dietary phosphate appear to have a direct effect on FGF23 release by bone cells that, in turn, causes renal phosphate excretion and decreases intestinal phosphate absorption through a decrease in vitamin D production.	Vitamin D	252-261	fibroblast growth factor 23	Homo sapiens	108-113
24973411-4	2014	Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis.	Vitamin D	83-92	fibroblast growth factor 23	Homo sapiens	51-56
24973411-4	2014	Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis.	Vitamin D	113-122	fibroblast growth factor 23	Homo sapiens	51-56
21803771-10	2011	Nephrin up-regulation likely accounts for part of the renoprotective activity of vitamin D.	Vitamin D	81-90	nephrosis 1, nephrin	Mus musculus	0-7
21637996-1	2011	The vitamin D receptor (VDR) is crucial for virtually all of vitamin D"s actions and is thought to be ubiquitously expressed.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
25053401-1	2014	Fibroblast growth factor 23 (FGF23) is secreted primarily by osteocytes and regulates phosphate and vitamin D metabolism.	Vitamin D	100-109	fibroblast growth factor 23	Mus musculus	0-27
25053401-1	2014	Fibroblast growth factor 23 (FGF23) is secreted primarily by osteocytes and regulates phosphate and vitamin D metabolism.	Vitamin D	100-109	fibroblast growth factor 23	Mus musculus	29-34
21637996-12	2011	Our results indicate that the VDR HET mouse is a useful model for studying the metabolic and skeletal impact of decreased vitamin D sensitivity.	Vitamin D	122-131	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	30-33
24630484-7	2014	The expression of MMP-9, MMP-2, and MMP-3 decreases in the presence of vitamin D derivatives in UC and CD with the exception of 1,25(OH)2D3 that does not affect the levels of MMP-9 and MMP-2 in CD.	Vitamin D	71-80	matrix metallopeptidase 9	Homo sapiens	18-23
24630484-8	2014	Vitamin D derivatives always affect MMP-9, MMP-2 and ICAM-1 in PBMC of UC and CD patients.	Vitamin D	0-9	matrix metallopeptidase 9	Homo sapiens	36-41
24630484-8	2014	Vitamin D derivatives always affect MMP-9, MMP-2 and ICAM-1 in PBMC of UC and CD patients.	Vitamin D	0-9	intercellular adhesion molecule 1	Homo sapiens	53-59
24630484-9	2014	CONCLUSIONS: Based on the increased expression of ICAM-1, MAdCAM-1 and MMP-2,-9,-3 in IBD, our study suggests that vitamin D derivatives may be effective in the management of these diseases.	Vitamin D	115-124	intercellular adhesion molecule 1	Homo sapiens	50-56
21941510-8	2011	Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	152-155
25016144-0	2014	Vitamin D supplementation promotes macrophages" anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	122-140
25016144-5	2014	When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	68-71
21941510-8	2011	Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	152-155
21561999-2	2011	FGF23 causes hypophosphatemia by decreasing the expression of sodium phosphate cotransporters (NaPi-2a and NaPi-2c) and decreasing serum 1,25(OH)(2)Vitamin D(3) levels.	Vitamin D	148-157	fibroblast growth factor 23	Mus musculus	0-5
25002714-12	2014	We observed interactions between 25-OHD level and VDR genotype, suggesting a causal relationship between vitamin D and survival.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	50-53
21872797-3	2011	When occupied by 1alpha,25(OH)2D3, the VDR-GP interacts with the retinoid X receptor to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1alpha,25(OH)2D3.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	39-42
24002366-0	2014	The effect of somatostatin analogs on vitamin D and calcium concentrations in patients with acromegaly.	Vitamin D	38-47	somatostatin	Homo sapiens	14-26
24748579-2	2014	However, recent studies suggest that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D.	Vitamin D	42-51	GC vitamin D binding protein	Homo sapiens	126-151
21872797-3	2011	When occupied by 1alpha,25(OH)2D3, the VDR-GP interacts with the retinoid X receptor to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1alpha,25(OH)2D3.	Vitamin D	121-130	retinoid X receptor alpha	Homo sapiens	65-84
24748579-2	2014	However, recent studies suggest that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D.	Vitamin D	240-249	GC vitamin D binding protein	Homo sapiens	126-151
21872797-4	2011	By recruiting complexes of either coactivators or corepressors, activated VDR modulates the transcription of genes encoding proteins that promulgate the traditional genomic functions of vitamin D, including signaling intestinal calcium and phosphate absorption to effect skeletal and calcium homeostasis.	Vitamin D	186-195	vitamin D receptor	Homo sapiens	74-77
21872809-1	2011	Vitamin D is a precursor for a secosteroid ligand of a major transcription factor, VDR, and is vital for normal bone mineralization.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	83-86
24382015-2	2014	Overexpression of CYP24A1, the primary vitamin D-inactivating enzyme, is also observed in a variety of human cancers, thus potentially neutralizing the antitumour effect of 1alpha, 25(OH)2 D3.	Vitamin D	39-48	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	18-25
21673104-1	2011	In recent years, vitamin D has received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries together with the identification of extraskeletal vitamin D receptor-mediated actions, suggesting unexpected benefits of vitamin D in health and diseases.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	191-209
24730464-2	2014	Factors of the vitamin D axis, which include vitamin D metabolites and vitamin D binding protein (VDBP), have been linked to asthma, but only few data exist about their regulation in the lung during acute allergen-induced airway inflammation.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	71-96
24730464-2	2014	Factors of the vitamin D axis, which include vitamin D metabolites and vitamin D binding protein (VDBP), have been linked to asthma, but only few data exist about their regulation in the lung during acute allergen-induced airway inflammation.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	98-102
24712573-2	2014	Vitamin D-binding protein (DBP) levels vary with race and may modulate "bioavailable" levels of 25(OH)D. OBJECTIVE: To determine the effect of DBP levels on the functional response to vitamin D.	Vitamin D	184-193	GC vitamin D binding protein	Homo sapiens	0-25
21613960-9	2011	CYP24A1 SNP rs2248137 was associated with lower vitamin D levels (P = 0.006).	Vitamin D	48-57	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	55-64	lipocalin 2	Homo sapiens	22-26
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	75-78
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	55-64	lipocalin 2	Homo sapiens	127-131
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	174-183	lipocalin 2	Homo sapiens	22-26
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	55-73
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	75-78
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	174-183	lipocalin 2	Homo sapiens	127-131
24939880-7	2014	The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.	Vitamin D	174-183	lipocalin 2	Homo sapiens	338-342
24926881-11	2014	Up-regulation of TLR2, TLR4 and dectin-1was observed in the lungs and AMs from vitamin D deficient mice both at baseline and after A. fumigatus exposure.	Vitamin D	79-88	C-type lectin domain family 7, member a	Mus musculus	32-40
21610497-2	2011	These changes are related and may be responsible for elevated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) and dysfunctional vitamin D metabolism.	Vitamin D	72-81	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	98-105
24917821-2	2014	Vitamin D- and p53-signaling pathways have a significant impact on spontaneous or carcinogen-induced malignant transformation of cells, with VDR and p53 representing important tumor suppressors.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	141-144
24740207-2	2014	Vitamin D-binding protein (DBP) is the primary carrier of vitamin D in the circulation and regulates the bioavailability of 25-hydroxyvitamin D.	Vitamin D	58-67	GC vitamin D binding protein	Homo sapiens	0-25
21610497-7	2011	New data from the uremic rat and humans suggest that dysfunctional vitamin D metabolism is due to changes in CYP24A1 expression caused by phosphate and FGF-23 elevations.	Vitamin D	67-76	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	109-116
24190584-2	2014	In vivo effects of vitamin D on PCFT and folate status are currently not available.	Vitamin D	19-28	solute carrier family 46, member 1	Mus musculus	32-36
21610497-7	2011	New data from the uremic rat and humans suggest that dysfunctional vitamin D metabolism is due to changes in CYP24A1 expression caused by phosphate and FGF-23 elevations.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	152-158
24643654-0	2014	Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells.	Vitamin D	84-93	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	26-33
21610497-8	2011	SUMMARY: Changes in serum phosphate and FGF-23 levels in the CKD patient increase CYP24A1 expression resulting in decreased vitamin D status.	Vitamin D	124-133	fibroblast growth factor 23	Homo sapiens	40-46
24643654-3	2014	Cell-autonomous control of vitamin D activity can be modulated by the action of the vitamin D-activating and -inactivating hydroxylases, CYP27B1, and CYP24A1, respectively.	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	150-157
24643654-3	2014	Cell-autonomous control of vitamin D activity can be modulated by the action of the vitamin D-activating and -inactivating hydroxylases, CYP27B1, and CYP24A1, respectively.	Vitamin D	84-93	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	150-157
21610497-8	2011	SUMMARY: Changes in serum phosphate and FGF-23 levels in the CKD patient increase CYP24A1 expression resulting in decreased vitamin D status.	Vitamin D	124-133	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	82-89
24643654-5	2014	Furthermore, in response to stimulation with 1,25[OH]2 D, upregulation of the inactivating enzyme CYP24A1 curtailed the functional effects of vitamin D in DCs, but not macrophages.	Vitamin D	142-151	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	98-105
21610497-10	2011	These findings argue for increased focus on correcting vitamin D deficiency in CKD patients by blocking CYP24A1 activity.	Vitamin D	55-64	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
24686054-3	2014	The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing, and immune response of murine microglial cultures after stimulation with the Toll-like receptor (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), poly(I C) (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9).	Vitamin D	65-74	toll-like receptor 9	Mus musculus	364-368
21654390-3	2011	RECENT FINDINGS: Findings from large-scale genome-wide association meta-analyses on 25(OH)D confirmed the associations for loci nearby genes encoding vitamin D binding protein (GC, group component), 7-dehydrochlesterol reductase (DHCR7), 25-hydroxylase (CYP2R1) and 24-hydroxylase (CYP24A1), all influencing key sites for vitamin D metabolism.	Vitamin D	150-159	7-dehydrocholesterol reductase	Homo sapiens	230-235
21654390-3	2011	RECENT FINDINGS: Findings from large-scale genome-wide association meta-analyses on 25(OH)D confirmed the associations for loci nearby genes encoding vitamin D binding protein (GC, group component), 7-dehydrochlesterol reductase (DHCR7), 25-hydroxylase (CYP2R1) and 24-hydroxylase (CYP24A1), all influencing key sites for vitamin D metabolism.	Vitamin D	150-159	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	282-289
21696575-11	2011	If VDR polymorphisms are found to influence the response to our intervention, then knowing distribution of VDR polymorphisms in both diabetic and non-diabetic populations can give a picture of the proportion of the community in whom up to 1000 IU/d vitamin D may not be effective enough to improve insulin resistance and related morbidities.	Vitamin D	249-258	vitamin D receptor	Homo sapiens	107-110
24347461-8	2014	The inclusion of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, in culture enhanced dexamethasone-induced IL-10 (p&lt;0.05) without marked effects on IL-13 or IL-17A production.	Vitamin D	36-45	interleukin 10	Homo sapiens	120-125
24347461-8	2014	The inclusion of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, in culture enhanced dexamethasone-induced IL-10 (p&lt;0.05) without marked effects on IL-13 or IL-17A production.	Vitamin D	36-45	interleukin 17A	Homo sapiens	173-179
24347461-9	2014	Furthermore, systemic vitamin D status directly correlated with airway IL-10 (r=0.6, p&lt;0.01).	Vitamin D	22-31	interleukin 10	Homo sapiens	71-76
24607320-2	2014	Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-94
24607320-2	2014	Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	71-89
21537045-9	2011	CONCLUSION: High VDR expression in prostate tumors is associated with a reduced risk of lethal cancer, suggesting a role of the vitamin D pathway in prostate cancer progression.	Vitamin D	128-137	vitamin D receptor	Homo sapiens	17-20
24773565-0	2014	Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	105-123
21497493-1	2011	Since its first description as a phosphaturic agent in the early 2000s, fibroblast growth factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism after PTH and vitamin D.	Vitamin D	194-203	fibroblast growth factor 23	Homo sapiens	72-99
24773565-3	2014	To develop tissue-selective VDR modulators, we have designed vitamin D analogues with an adamantane ring at the side chain terminal, which would interfere with helix 12, the activation function 2, and modulate the VDR potency.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	28-31
24773565-3	2014	To develop tissue-selective VDR modulators, we have designed vitamin D analogues with an adamantane ring at the side chain terminal, which would interfere with helix 12, the activation function 2, and modulate the VDR potency.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	214-217
24849345-4	2014	In mice fed a vitamin D-deficient diet, lower cerebral P-gp expression was observed, but levels were restored on replenishment with VDR ligands.	Vitamin D	14-23	phosphoglycolate phosphatase	Mus musculus	55-59
21497493-1	2011	Since its first description as a phosphaturic agent in the early 2000s, fibroblast growth factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism after PTH and vitamin D.	Vitamin D	194-203	fibroblast growth factor 23	Homo sapiens	101-106
24849345-4	2014	In mice fed a vitamin D-deficient diet, lower cerebral P-gp expression was observed, but levels were restored on replenishment with VDR ligands.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	132-135
21521263-2	2011	Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	29-47
21521263-2	2011	Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	49-52
24761763-5	2014	Furthermore, due to regulated expression of the metabolizing enzymes CYP27B1 and CYP24A1, B cells have the potential to control the local availability of active vitamin D.	Vitamin D	161-170	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	81-88
21521263-2	2011	Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	159-162
21404002-1	2011	Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance.	Vitamin D	164-173	fibroblast growth factor 23	Homo sapiens	0-27
24790904-2	2014	Recent research on the various molecular activities of the vitamin D system, including the nuclear vitamin D receptor and other receptors for 1,25-dihydroxyvitamin D and vitamin D metabolism, provides evidence that the vitamin D system carries out biological activities across a wide range of tissues similar to other nuclear receptor hormones.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	99-117
24790904-7	2014	The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vitamin D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	139-157
24790904-7	2014	The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vitamin D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	236-254
21404002-1	2011	Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance.	Vitamin D	164-173	fibroblast growth factor 23	Homo sapiens	29-34
21348760-8	2011	In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer.	Vitamin D	181-190	vitamin D receptor	Homo sapiens	216-219
24510435-1	2014	BACKGROUND: Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	80-98
21348760-8	2011	In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer.	Vitamin D	181-190	vitamin D receptor	Homo sapiens	221-239
24510435-1	2014	BACKGROUND: Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	100-103
21595846-0	2011	Role of megalin and cubilin in the metabolism of vitamin D(3).	Vitamin D	49-58	cubilin	Homo sapiens	20-27
21378269-10	2011	CONCLUSIONS: These meta-analyses support the evidence of an inverse association between vitamin D intake, 25-hydroxyvitamin D status, and the BsmI VDR polymorphism and CRC risk.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	147-150
24531265-0	2014	Matrix metalloproteinase-10 and microvascular complications of type 1 diabetes: might vitamin D status be relevant?	Vitamin D	86-95	matrix metallopeptidase 10	Homo sapiens	0-27
24558197-0	2014	Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	30-33
24558197-9	2014	The fetus may regulate placental VDR expression given the significant associations with neonatal vitamin D metabolites.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	33-36
21167925-0	2011	Vitamin D-deficient diet rescues hearing loss in Klotho mice.	Vitamin D	0-9	klotho	Mus musculus	49-55
24408013-1	2014	The vitamin D receptor (VDR) can influence cancer susceptibility through binding to vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
21167925-4	2011	It was further demonstrated that a vitamin D-deficient diet normalizes serum calcitriol (1,25(OH)(2)D(3)) levels and prevents hearing loss in Klotho mice.	Vitamin D	35-44	klotho	Mus musculus	142-148
24808866-7	2014	Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	84-102
24808866-7	2014	Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	104-107
24808866-7	2014	Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation.	Vitamin D	31-40	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	200-207
24808867-10	2014	In conclusion, a genome-wide (over)view on the genomic locations of VDR provides a broader basis for addressing vitamin D"s role in health and disease.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	68-71
21337382-0	2011	Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.	Vitamin D	26-35	parathyroid hormone	Bos taurus	15-18
24710520-2	2014	In Hyp mice, a murine model for X-linked hypophosphatemia (XLH), Phex deficiency results in the overproduction of FGF23 in osteocytes, which leads to hypophosphatemia and impaired vitamin D metabolism.	Vitamin D	180-189	fibroblast growth factor 23	Mus musculus	114-119
24146318-1	2014	BACKGROUND: In order for vitamin D to signal and regulate inflammatory pathways, it must bind to its receptor (VDR) which must heterodimerize with the retinoid X receptor alpha (RXRalpha).	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	111-114
21337382-0	2011	Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.	Vitamin D	26-35	GC vitamin D binding protein	Bos taurus	104-129
24338253-0	2014	The effects of vitamin D on allergen-induced expression of interleukin-13 and interleukin-17 in cord blood CD4+T cells.	Vitamin D	15-24	interleukin 17A	Homo sapiens	78-92
21186064-0	2011	Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.	Vitamin D	0-9	CD8a molecule	Homo sapiens	50-53
23681781-0	2014	Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	27-30
23681781-0	2014	Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling.	Vitamin D	70-79	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	41-44
23681781-5	2014	KO cells expressing hVDR with the G46D point mutation, which abrogates VDR binding to DR3 response elements, exhibited partial growth inhibition in response to 1,25D and synthetic vitamin D analogs, providing proof of principle that VDR signaling through alternative genomic or non-genomic mechanisms contributes to vitamin D mediated growth effects in transformed cells.	Vitamin D	180-189	vitamin D receptor	Homo sapiens	21-24
23681781-5	2014	KO cells expressing hVDR with the G46D point mutation, which abrogates VDR binding to DR3 response elements, exhibited partial growth inhibition in response to 1,25D and synthetic vitamin D analogs, providing proof of principle that VDR signaling through alternative genomic or non-genomic mechanisms contributes to vitamin D mediated growth effects in transformed cells.	Vitamin D	316-325	vitamin D receptor	Homo sapiens	21-24
21186064-1	2011	Little is known on a putative effect of vitamin D on CD8+ T cells.	Vitamin D	40-49	CD8a molecule	Homo sapiens	53-56
23959712-2	2014	Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP).	Vitamin D	17-26	GC vitamin D binding protein	Homo sapiens	52-77
26746857-3	2011	Klotho(-/-)mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1alpha-hydroxylase, vitamin D receptor, or NaPi cotransporter).	Vitamin D	238-247	klotho	Mus musculus	0-6
24529992-6	2014	1,25(OH)2D is the ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs).	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
21300024-2	2011	Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	42-60
24618509-1	2014	FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	51-54
21300024-2	2011	Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	62-65
21408608-12	2011	Although vitamin D regulates LVSCC-A1C through VDR, it may not regulate LVSCC-A1D through VDR.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	47-50
24818002-1	2014	Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR).	Vitamin D	48-57	vitamin D receptor	Homo sapiens	68-71
24818002-1	2014	Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR).	Vitamin D	88-97	vitamin D receptor	Homo sapiens	48-66
24818002-1	2014	Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR).	Vitamin D	88-97	vitamin D receptor	Homo sapiens	68-71
21309754-9	2011	Our findings suggest VDR as a potential susceptibility gene and support an essential role of vitamin D in PD.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	21-24
23995104-1	2014	Vitamin D deficiency is associated with higher cardiovascular risk and metabolic syndrome (MeS) criteria.	Vitamin D	0-9	MKS transition zone complex subunit 1	Homo sapiens	91-94
21454240-7	2011	CONCLUSION: Future studies investigating the relationship of the vitamin D receptor, calcium-sensing receptor, and parathyroid glands are needed to enhance our knowledge of vitamin D deficiency and primary and secondary vitamin D deficiency.	Vitamin D	173-182	vitamin D receptor	Homo sapiens	65-83
21242105-6	2011	Though vitamin D"s anti-viral mechanism has not been fully established, it may be linked to vitamin D"s ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2.	Vitamin D	7-16	defensin beta 4B	Homo sapiens	171-186
24499465-4	2014	Vitamin D signalling (VDS) protects against skin cancer as demonstrated by the susceptibility of the skin to tumor formation in VDR null mice and protection from UVB-induced mutations when VDR agonists are administered.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	128-131
21242105-6	2011	Though vitamin D"s anti-viral mechanism has not been fully established, it may be linked to vitamin D"s ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2.	Vitamin D	92-101	defensin beta 4B	Homo sapiens	171-186
24499465-4	2014	Vitamin D signalling (VDS) protects against skin cancer as demonstrated by the susceptibility of the skin to tumor formation in VDR null mice and protection from UVB-induced mutations when VDR agonists are administered.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	189-192
23907847-7	2014	The maternal free 25(OH)-vitamin D index was negatively associated with methylation at one of these RXRA CpG sites (beta = -3.3 SD/unit, p = 0.03).	Vitamin D	25-34	retinoid X receptor alpha	Homo sapiens	100-104
21042807-3	2011	Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been found to influence vitamin D levels.	Vitamin D	150-159	GC vitamin D binding protein	Homo sapiens	0-25
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Vitamin D	194-203	fibroblast growth factor 23	Mus musculus	70-75
20980105-4	2011	Binding of the active vitamin D metabolite 1,25(OH)(2)D(3) to vitamin D receptor (VDR) yields a transcription factor which represses NF-kappaB activation, and additionally modulates and down-regulates adaptive, but enhances innate immune responses, and improves redox balance, thus counterbalancing inflammation on multiple levels.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	62-80
23368852-11	2014	CONCLUSION: The association between vitamin D deficiency and MCC characteristics and outcome, together with detection of the VDR in MCC cells, suggest that vitamin D could influence the biology of MCC.	Vitamin D	156-165	vitamin D receptor	Homo sapiens	125-128
20980105-4	2011	Binding of the active vitamin D metabolite 1,25(OH)(2)D(3) to vitamin D receptor (VDR) yields a transcription factor which represses NF-kappaB activation, and additionally modulates and down-regulates adaptive, but enhances innate immune responses, and improves redox balance, thus counterbalancing inflammation on multiple levels.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	82-85
24343899-1	2014	Vitamin D receptor (VDR) mediates vitamin D signaling involved in bone metabolism, cellular growth and differentiation, cardiovascular function, and bile acid regulation.	Vitamin D	34-43	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
21131899-1	2011	BACKGROUND: Apart from their important role in mediating calcium homeostasis, vitamin D derivatives regulate numerous vitamin D receptor-mediated renoprotective cellular functions including cell differentiation, negative regulation of inflammation, and fibrosis.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	118-136
24343899-1	2014	Vitamin D receptor (VDR) mediates vitamin D signaling involved in bone metabolism, cellular growth and differentiation, cardiovascular function, and bile acid regulation.	Vitamin D	34-43	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
21215445-14	2011	Vitamin D did not significantly affect time to sputum culture conversion in the whole study population, but it did significantly hasten sputum culture conversion in participants with the tt genotype of the TaqI vitamin D receptor polymorphism.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	211-229
25568836-12	2014	INTERPRETATION: The known MS risk allele rs2248359-C increases CYP24A1 expression in human brain providing a genetic link between MS and vitamin D metabolism, and predicting that the physiologically active form of vitamin D3 is protective.	Vitamin D	137-146	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	63-70
24419359-2	2014	The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	128-146
24419359-2	2014	The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	148-151
21047796-8	2011	These data suggest that vitamin D deficiency may promote autoimmunity by favoring the inordinate production of Th17 and Th9 cells at the expense of regulatory IL-10-producing T cells.	Vitamin D	24-33	interleukin 10	Homo sapiens	159-164
24553867-3	2014	Vitamin D is through stimulating vitamin D receptor to form a transcriptional complex with cofactors to modulate approximately 3% gene transcription.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	33-51
21062631-11	2011	SIGNIFICANCE: These results suggest that the vitamin D metabolite 24, 25-(OH)(2)D(3) is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	143-146
24486205-1	2014	1alpha,25-Dihydroxyvitamin D3 [1alpha,25(OH)2D3: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates for multiple clinical applications.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	87-105
24486205-1	2014	1alpha,25-Dihydroxyvitamin D3 [1alpha,25(OH)2D3: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates for multiple clinical applications.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	107-110
21114675-2	2011	T cells express the vitamin D receptor (VDR) and have been shown to be direct and indirect vitamin D targets.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	40-43
24313624-0	2014	Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells.	Vitamin D	5-14	interleukin 17A	Homo sapiens	80-85
23857798-2	2014	The majority of vitamin D in circulation is bound to vitamin D-binding protein (DBP) and albumin, and recent genetic studies have demonstrated that serum DBP is a major determinant of 25(OH)D concentrations in adults.	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	53-78
21625107-5	2011	In the chronic kidney disease (CKD) population, vitamin D receptor (VDR) activation deficiency is even more severe than in a non-CKD population, with a 25-(OH) vitamin D level being an independent predictor of all-cause mortality.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	68-71
23924903-0	2014	Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D.	Vitamin D	102-111	interleukin 17A	Homo sapiens	35-40
21291397-7	2011	The three-dimensional structure of both rat and human VDR-LBD have provided significant information for our understanding of the structure-function relationship (SFR) of vitamin D and some synthetic analogs.	Vitamin D	170-179	vitamin D receptor	Homo sapiens	54-57
24306365-9	2014	There was a significant inverse correlation between MMP9 and vitamin D levels (r=-0.41, p=0.01).	Vitamin D	61-70	matrix metallopeptidase 9	Homo sapiens	52-56
24219580-9	2014	Vitamin D deficiency and its association with VDR gene polymorphisms may be useful to identify the high-risk group individuals.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	46-49
21897759-2	2011	The discovery of Fibroblast Growth Factor 23 (FGF23) has revolutionized our understanding about the links between mineral metabolism, vitamin D and parathyroid hormone (PTH).	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	17-44
21897759-2	2011	The discovery of Fibroblast Growth Factor 23 (FGF23) has revolutionized our understanding about the links between mineral metabolism, vitamin D and parathyroid hormone (PTH).	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	46-51
24498064-1	2014	Vitamin D binding protein (DBP)/group-specific component (Gc), correlates positively with serum vitamin D metabolites, and phenotype influences serum 25-hydroxyvitamin D (S-25(OH)D) concentration.	Vitamin D	96-105	GC vitamin D binding protein	Homo sapiens	0-25
24190897-3	2014	DKKL1 mRNA was repressed 49-72% by 1,25D in primary human and CCD-1106 KERTr keratinocytes; a functional vitamin D responsive element (VDRE) was identified at -9590 bp in murine Soggy.	Vitamin D	105-114	dickkopf like acrosomal protein 1	Homo sapiens	0-5
21542721-8	2011	Also, the levels of transforming growth factor-beta and interleukin-10 in the vitamin D treatment group were significantly higher than the control group.	Vitamin D	78-87	interleukin 10	Homo sapiens	56-70
25566549-6	2014	Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	109-127
25566549-6	2014	Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	128-131
21765616-5	2011	The amount of IL-8 secreted by NK cells was increased by IL-15 treatment from levels of 88.64 +- 21.5 to 178.9 +- 23.6 Pg/mL and was significantly reduced by 10(-6) M vitamin D(3) to levels of 59.2 +- 16.3 Pg/mL.	Vitamin D	167-176	interleukin 15	Homo sapiens	57-62
21765616-6	2011	Our results indicate a novel inflammatory crosstalk between NK cells and eosinophils via IL-15/IL-8 axis that can be modulated by vitamin D(3).	Vitamin D	130-139	interleukin 15	Homo sapiens	89-94
22046258-10	2011	In the North Carolina AAs, for whom we had vitamin D intake data, we found a significant association between an intronic SNP rs11574041 and vitamin D intake, which is evidence for a VDR gene-environment interaction in AAs.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	182-185
24535626-10	2014	CONCLUSIONS: These results suggest that TDF-containing cART may alter the FGF23 response to vitamin D supplementation in HIV-infected youths.	Vitamin D	92-101	fibroblast growth factor 23	Homo sapiens	74-79
21419266-7	2011	These include coordinated actions of the vitamin D-activating enzyme, 1alpha-hydroxylase (CYP27B1), and the vitamin D receptor (VDR) in mediating intracrine and paracrine actions of vitamin D.	Vitamin D	108-117	vitamin D receptor	Homo sapiens	128-131
21058632-3	2010	A convenient and reliable cell-free assay was established and used to screen vitamin D analogues with potential inhibitory properties toward CYP24A1.	Vitamin D	77-86	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	141-148
25227839-2	2014	Vitamin D may have an anticancer effect in colorectal cancer mediated by binding of the active form 1,25(OH)2D to the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	118-136
25227839-2	2014	Vitamin D may have an anticancer effect in colorectal cancer mediated by binding of the active form 1,25(OH)2D to the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	138-141
20863562-2	2010	The actions of vitamin D are mediated by the vitamin D receptor that binds the active form of vitamin D [1,25(OH)(2)D] to induce both transcriptional and non-genomic responses.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	45-63
25197630-6	2014	Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	48-51
25171473-8	2014	RESULTS AND CONCLUSION: Proteomics analyses demonstrated that the proteins involved in vitamin D/E binding, heme/iron binding and transportation, and lipid/steroid transportation/metabolic systems were down-regulated in colon cancer and the same set of proteins were down-regulated in the LXR/RXR activation and acute-phase response pathways, revealing a plausible mechanistic connection between vitamin D deficiency, iron homeostasis, and colon cancer.	Vitamin D	87-96	retinoid X receptor alpha	Homo sapiens	293-296
24438630-7	2014	Mounting evidences from animal and clinical studies have suggested that vitamin D therapy has beneficial effects on the renal systems and the underlying renoprotective mechanisms of the vitamin D receptor-mediated signaling pathways is a hot research topic.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	186-204
24200978-0	2014	Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	50-53
24699387-7	2014	These same genes were associated with several late-life phenotypes: VDR-BsmI, TaqI and ApaI determined the relationship between dietary vitamin D and both insulin (P &lt; 0.0001/BB, 0.0007/tt and 0.0173/AA, respectively) and systolic blood pressure (P = 0.0290/Bb, 0.0299/Tt and 0.0412/AA, respectively), making them important early and late in the lifecycle.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	68-71
23775785-6	2014	We focused on the effect of these compounds on the stimulation of expression of human cathelicidin antimicrobial peptide (CAMP) whose gene has a vitamin D response element in its promoter.	Vitamin D	145-154	cathelicidin antimicrobial peptide	Mus musculus	86-120
23775785-6	2014	We focused on the effect of these compounds on the stimulation of expression of human cathelicidin antimicrobial peptide (CAMP) whose gene has a vitamin D response element in its promoter.	Vitamin D	145-154	cathelicidin antimicrobial peptide	Mus musculus	122-126
24899892-1	2014	Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses.	Vitamin D	65-74	GC vitamin D binding protein	Homo sapiens	0-25
23296792-1	2014	Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis.	Vitamin D	100-109	fibroblast growth factor 23	Homo sapiens	0-27
23296792-1	2014	Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis.	Vitamin D	100-109	fibroblast growth factor 23	Homo sapiens	29-35
24967273-8	2014	The circulating interleukin-(IL-)10 and interferon-(IFN-) gamma concentrations were significantly higher in the vitamin D sufficient athletes.	Vitamin D	112-121	interleukin 10	Homo sapiens	16-63
23623649-1	2014	Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis.	Vitamin D	139-148	fibroblast growth factor 23	Homo sapiens	0-27
23623649-1	2014	Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis.	Vitamin D	139-148	fibroblast growth factor 23	Homo sapiens	29-35
24284821-8	2014	Our data demonstrate the importance of intact VDR signaling in the preservation of vascular function and may provide a mechanistic explanation for epidemiological data in humans showing that vitamin D insufficiency is associated with hypertension and endothelial dysfunction.	Vitamin D	191-200	vitamin D receptor	Homo sapiens	46-49
26168131-4	2014	The vitamin D receptor (VDR) as a steroid hormone superfamily of nuclear receptors is highly expressed in epithelial cells at risk for carcinogenesis, providing a direct molecular link by which vitamin D status impacts on carcinogenesis.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
26168131-5	2014	Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	8-11
24010964-0	2013	Novel targets of vitamin D activity in bone: action of the vitamin D receptor in osteoblasts, osteocytes and osteoclasts.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	59-77
24010964-1	2013	The active form of vitamin D, 1,25-dihydroxyvitamin D3, carries out its diverse range of biological activities by binding to the nuclear vitamin D receptor, present in almost every cell of the body.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	137-155
24102630-1	2013	Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	36-54
24102630-1	2013	Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	56-59
24011919-12	2013	The prior treatment with PPAR-gamma antagonist bisphenol A diglycidyl ether significantly attenuated protective effect of vitamin D, thus confirming involvement of PPAR-gamma in vitamin D-mediated renoprotection.	Vitamin D	122-131	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	25-35
24011919-12	2013	The prior treatment with PPAR-gamma antagonist bisphenol A diglycidyl ether significantly attenuated protective effect of vitamin D, thus confirming involvement of PPAR-gamma in vitamin D-mediated renoprotection.	Vitamin D	122-131	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	164-174
24011919-12	2013	The prior treatment with PPAR-gamma antagonist bisphenol A diglycidyl ether significantly attenuated protective effect of vitamin D, thus confirming involvement of PPAR-gamma in vitamin D-mediated renoprotection.	Vitamin D	178-187	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	25-35
24011919-12	2013	The prior treatment with PPAR-gamma antagonist bisphenol A diglycidyl ether significantly attenuated protective effect of vitamin D, thus confirming involvement of PPAR-gamma in vitamin D-mediated renoprotection.	Vitamin D	178-187	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	164-174
24011919-13	2013	CONCLUSIONS: It is concluded that activation of PPAR-gamma significantly contributes toward vitamin D-mediated protection against ischemia reperfusion-induced AKI.	Vitamin D	92-101	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	48-58
24124751-4	2013	Klotho serves as a co-receptor for fibroblast growth factor (FGF), but it also functions as a humoral factor that regulates cell survival and proliferation, vitamin D metabolism, and calcium and phosphate homeostasis and may serve as a potential tumor suppressor.	Vitamin D	157-166	klotho	Mus musculus	0-6
24078452-1	2013	The polymorphism of vitamin D receptor (VDR) gene is demonstrated to affect the activity of its encoding protein and the subsequent downstream effects mediated by vitamin D.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	40-43
24264043-0	2013	Alteration of tight junction gene expression by calcium- and vitamin D-deficient diet in the duodenum of calbindin-null mice.	Vitamin D	61-70	calbindin 1	Mus musculus	105-114
23664548-3	2013	In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency.	Vitamin D	311-320	fibroblast growth factor 23	Homo sapiens	218-245
23664548-3	2013	In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency.	Vitamin D	311-320	fibroblast growth factor 23	Homo sapiens	247-253
24386512-3	2013	In this report, in vitro and in vivo anticancer efficacy, safety, and details of vitamin D receptor (VDR) interactions of PT19c, a novel nonhypercalcemic vitamin D derived anticancer agent, are described.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	101-104
24007780-5	2013	Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06).	Vitamin D	10-19	interleukin 17A	Homo sapiens	149-154
23500379-0	2013	Relationship between vitamin D receptor gene (VDR) polymorphisms, vitamin D status, osteoarthritis and intervertebral disc degeneration.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	46-49
23500379-8	2013	In the future, given the role of vitamin D system in the cartilaginous tissue metabolism, it could be interesting to perform functional and tissue specific studies to analyze the interplay between the different VDR variants and its ligand.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	211-214
20719979-3	2010	Klotho hypomorphic mice (klotho(hm)) suffer from severe growth deficit, rapid aging, and early death, events largely reversed by a vitamin D-deficient diet.	Vitamin D	131-140	klotho	Mus musculus	0-6
23852336-1	2013	BACKGROUND: The relationship between fibroblast growth factor 23 (FGF23) and vitamin D production and catabolism post-renal transplantation has not been characterized.	Vitamin D	77-86	fibroblast growth factor 23	Homo sapiens	37-64
23852336-1	2013	BACKGROUND: The relationship between fibroblast growth factor 23 (FGF23) and vitamin D production and catabolism post-renal transplantation has not been characterized.	Vitamin D	77-86	fibroblast growth factor 23	Homo sapiens	66-71
20719979-3	2010	Klotho hypomorphic mice (klotho(hm)) suffer from severe growth deficit, rapid aging, and early death, events largely reversed by a vitamin D-deficient diet.	Vitamin D	131-140	klotho	Mus musculus	25-31
21030971-1	2010	Fibroblast growth factor 23 (FGF23) modulates the metabolism of minerals and vitamin D.	Vitamin D	77-86	fibroblast growth factor 23	Homo sapiens	0-27
24075759-13	2013	Both platelet activation inhibitor-1 and tissue plasminogen activator levels fell significantly in the vitamin D group relative to placebo at 8 weeks.	Vitamin D	103-112	chromosome 20 open reading frame 181	Homo sapiens	41-69
24076645-2	2013	Now the most attention is paid to FGF23 blockades as a new category of therapy that may replace the current supplementation of phosphate and active vitamin D.	Vitamin D	148-157	fibroblast growth factor 23	Mus musculus	34-39
24076648-5	2013	On the basis of these data, it is suggested that appropriate doses of active vitamin D and phosphate are to be selected according to the data of serum PTH, ALP and the amount of urinary excretion of calcium.	Vitamin D	77-86	ATHS	Homo sapiens	156-159
24251203-7	2013	The results indicate a potential antidiabetic function of vitamin D on GLUT1, GLUT4, VDR, and IR by improving receptor gene expression suggesting a role for vitamin D in regulation of expression of the glucose transporters in muscle cells.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	85-88
21030971-1	2010	Fibroblast growth factor 23 (FGF23) modulates the metabolism of minerals and vitamin D.	Vitamin D	77-86	fibroblast growth factor 23	Homo sapiens	29-34
20730630-15	2010	Fgf23 regulates serum phosphate and active vitamin D levels.	Vitamin D	43-52	fibroblast growth factor 23	Homo sapiens	0-5
23657144-2	2013	In order to determine how early this increase occurs, we used a murine folic acid-induced nephropathy model and found that plasma FGF23 levels increased significantly from baseline already after 1 h of AKI, with an 18-fold increase at 24 h. Similar elevations of FGF23 levels were found when AKI was induced in mice with osteocyte-specific parathyroid hormone receptor ablation or the global deletion of parathyroid hormone or the vitamin D receptor, indicating that the increase in FGF23 was independent of parathyroid hormone and vitamin D signaling.	Vitamin D	431-440	fibroblast growth factor 23	Mus musculus	130-135
23945129-2	2013	Currently, several genes have been associated with SLE susceptibility, including vitamin D receptor (VDR), which is a mediator of immune responses through the action of vitamin D.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	101-104
23945129-3	2013	Polymorphisms in the VDR gene can impair the vitamin D (D3) function role, and since SLE patients show deficient D3 blood levels, it leads to a possible connection to the disease"s onset.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	21-24
20733087-2	2010	Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding protein or free vitamin D levels.	Vitamin D	12-21	GC vitamin D binding protein	Homo sapiens	50-75
23906633-6	2013	Here we show, using human patient samples from individuals with hereditary vitamin D resistant rickets, that the VDR directly inhibits the expression of uncoupling protein-1 (UCP1), the critical protein for uncoupling fatty acid oxidation in brown fat and burning energy.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	113-116
20886077-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: In an in vitro system using cells from mice, the active form of vitamin D(3) (1,25-dihydroxyvitamin D(3)) suppresses both interleukin (IL)-17-producing T cells (T(H)17) and regulatory T cells (Treg) differentiation via a vitamin D receptor signal.	Vitamin D	96-105	interleukin 17A	Mus musculus	154-173
23807674-1	2013	The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
24358684-6	2013	Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production.	Vitamin D	0-9	interleukin 17A	Homo sapiens	25-30
24358684-6	2013	Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	73-76
20886077-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: In an in vitro system using cells from mice, the active form of vitamin D(3) (1,25-dihydroxyvitamin D(3)) suppresses both interleukin (IL)-17-producing T cells (T(H)17) and regulatory T cells (Treg) differentiation via a vitamin D receptor signal.	Vitamin D	96-105	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	253-271
20831823-0	2010	Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	100-103
23721405-1	2013	Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the pancreas.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	0-18
23721405-2	2013	Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	47-50
23721405-2	2013	Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	123-126
20831823-0	2010	Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions.	Vitamin D	15-24	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
24034921-8	2013	1,25-(OH)2D3 inhibits the expression of IL-13 and IL-17, suggesting that vitamin D intake may provide protective effects in the development of atopy-predisposing immune responses in early life.	Vitamin D	73-82	interleukin 17A	Homo sapiens	50-55
20831823-12	2010	Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone.	Vitamin D	150-159	vitamin D receptor	Homo sapiens	137-140
20616160-1	2010	The role of vitamin D in multiple organ systems has come into sharp focus with recent advances in the understanding of its mechanisms of actions and specific effects of vitamin D preparations that serve as substrates and those that directly activate the vitamin D receptor.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	254-272
23639358-8	2013	Addition of vitamin D in the diet, however, increases fat levels in klf-3 worms.	Vitamin D	12-21	Kruppel like factor 3	Homo sapiens	68-73
23232694-4	2013	We studied TFIIH-dependent transactivation by nuclear receptor for vitamin D (VDR) and thyroid in cells from these patients.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	78-81
23232694-5	2013	The vitamin D stimulation ratio of CYP24 and osteopontin was associated with specific pairs of mutations (reduced in 5, elevated in 1) but not correlated with distinct clinical phenotypes.	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	35-40
23619147-15	2013	Reagents designed to target JMJD1A or its messenger RNA, or increase the function of miR-627, might have the same antitumor activities of vitamin D without the hypercalcemic side effects.	Vitamin D	138-147	lysine (K)-specific demethylase 3A	Mus musculus	28-34
23683514-2	2013	We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10.	Vitamin D	57-66	interleukin 10	Homo sapiens	190-195
23683514-3	2013	OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3).	Vitamin D	304-313	interleukin 17A	Homo sapiens	84-90
23683514-3	2013	OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3).	Vitamin D	304-313	interleukin 22	Homo sapiens	95-100
23470222-13	2013	CYP24A1 mutations should be considered in the differential diagnosis of hypercalciuric nephrolithiasis, especially as many adults are now prescribed supplemental oral vitamin D.	Vitamin D	167-176	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
20506379-1	2010	Vitamin D is a steroid pro-hormone, whose active metabolite binds the vitamin D receptor (VDR) which, in turn, binds to DNA sequences on target genes as a heterodimer with the retinoid-X receptor, resulting in regulation of gene expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	70-88
23865526-5	2013	An involvement of MLN could explain the diverse findings in the epidemiology, immunology and pathology of MS, requiring a consideration of a complex infectious background, the human leucocyte antigens, as well as cosmic radiation causing geomagnetic disturbances, vitamin D deficiency, smoking, and lower levels of uric acid.	Vitamin D	264-273	motilin	Homo sapiens	18-21
23857228-1	2013	The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF).	Vitamin D	108-117	vitamin D receptor	Homo sapiens	273-291
23857228-1	2013	The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF).	Vitamin D	108-117	vitamin D receptor	Homo sapiens	293-296
23857228-1	2013	The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF).	Vitamin D	108-117	GC vitamin D binding protein	Homo sapiens	306-376
23857228-1	2013	The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF).	Vitamin D	108-117	vitamin D receptor	Homo sapiens	273-291
20506379-1	2010	Vitamin D is a steroid pro-hormone, whose active metabolite binds the vitamin D receptor (VDR) which, in turn, binds to DNA sequences on target genes as a heterodimer with the retinoid-X receptor, resulting in regulation of gene expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	90-93
23857228-1	2013	The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF).	Vitamin D	108-117	vitamin D receptor	Homo sapiens	293-296
23857228-1	2013	The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF).	Vitamin D	108-117	GC vitamin D binding protein	Homo sapiens	306-376
20506379-1	2010	Vitamin D is a steroid pro-hormone, whose active metabolite binds the vitamin D receptor (VDR) which, in turn, binds to DNA sequences on target genes as a heterodimer with the retinoid-X receptor, resulting in regulation of gene expression.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	176-195
23857228-5	2013	This allows 1,25(OH)(2)D3 and oleic acid to become sandwiched between the two vitamin D-binding proteins, thus postulating a novel molecular mode of interaction between GcMAF and VDR.	Vitamin D	78-87	GC vitamin D binding protein	Homo sapiens	169-174
20506379-4	2010	Investigations into the pathophysiologic basis and therapeutic responses of skeletal disorders associated with impaired vitamin D action have led to the identification of the molecular pathways involved in hormone activation and regulation of gene expression by the liganded VDR.	Vitamin D	120-129	vitamin D receptor	Homo sapiens	275-278
23857228-5	2013	This allows 1,25(OH)(2)D3 and oleic acid to become sandwiched between the two vitamin D-binding proteins, thus postulating a novel molecular mode of interaction between GcMAF and VDR.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	179-182
20488884-1	2010	A central paradox of vitamin D biology is that 1alpha,25-(OH)(2) D(3) exposure inversely relates to colorectal cancer (CRC) risk despite a capacity for activation of both pro- and anti-oncogenic mediators including osteopontin (OPN)/CD44 and E-cadherin, respectively.	Vitamin D	21-30	CD44 molecule (Indian blood group)	Homo sapiens	233-237
23877860-0	2013	LPS and HIV gp120 modulate monocyte/macrophage CYP27B1 and CYP24A1 expression leading to vitamin D consumption and hypovitaminosis D in HIV-infected individuals.	Vitamin D	89-98	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	59-66
23877860-3	2013	PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS).	Vitamin D	99-108	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	159-166
23877860-3	2013	PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS).	Vitamin D	99-108	vitamin D receptor	Homo sapiens	171-189
20675935-3	2010	Loss-of-function mutation of 1alpha-hydroxylase gene and loss-of-function mutation of VDR gene result in vitamin D-dependent rickets type I and type II, respectively.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	86-89
23877860-3	2013	PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS).	Vitamin D	99-108	vitamin D receptor	Homo sapiens	191-194
23022574-3	2013	The active form of vitamin D [1,25(OH)2D] plays a crucial role in regulating the transfer of calcium between blood and bone, evidenced by experimental data obtained from systemic, intestinal-specific and osteocyte-specific vitamin D receptor (Vdr) null mice.	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	243-246
20432439-7	2010	Mammalian two-hybrid and co-immunoprecipitation assays revealed a vitamin-D-independent interaction between steroid receptor co-activator-1 (SRC-1) and RXRalpha that was reduced by MAPK activation and was restored in RWPE2 cells by mutating S32 and T82 in the RXRalpha AF-1 domain.	Vitamin D	66-75	retinoid X receptor alpha	Homo sapiens	152-160
20432439-7	2010	Mammalian two-hybrid and co-immunoprecipitation assays revealed a vitamin-D-independent interaction between steroid receptor co-activator-1 (SRC-1) and RXRalpha that was reduced by MAPK activation and was restored in RWPE2 cells by mutating S32 and T82 in the RXRalpha AF-1 domain.	Vitamin D	66-75	retinoid X receptor alpha	Homo sapiens	260-268
23059470-5	2013	Such studies suggest that vitamin D production and subsequent signaling through the VDR in the skin may have evolved in part as a protective mechanism against UVR induced epidermal cancer formation.	Vitamin D	26-35	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	84-87
20334872-11	2010	VDR expression is unlikely to represent an independent prognostic factor, but its presence within biopsy specimens might be used to identify patients that are suited to high-dose vitamin D therapeutic trials.	Vitamin D	179-188	vitamin D receptor	Homo sapiens	0-3
23059472-0	2013	Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1alpha-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	79-97
23059472-10	2013	This is the first report to describe direct regulation of VDR and 1OHase expression by a vitamin D analog in human thyroid cancer cells.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	58-61
23059474-5	2013	There is increasing evidence linking the incidence and prognosis of certain cancers to low serum 25(OH)D3 levels and high expression of vitamin D 24-hydroxylase, supporting the idea that elevated CYP24A1 expression may stimulate degradation of vitamin D metabolites including 25(OH)D3 and 1,25(OH)2D3.	Vitamin D	136-145	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	196-203
22995734-9	2013	We present our recently published data showing two single nucleotide polymorphisms in vitamin D catabolic enzyme CYP24A1 associated with higher risk of estrogen ER-negative risk in AA than in EA women.	Vitamin D	86-95	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	113-120
20394945-3	2010	Vitamin D receptor expression (VDR), 24-hydroxylase activity, and functional gene polymorphisms of vitamin D metabolism regulators VDR(rs4516035), 1-hydroxylase(rs10877012), 24-hydroxylase(rs2248359), FGF23(rs7955866), Klotho(rs9536314, rs564481, rs648202), were evaluated.	Vitamin D	99-108	klotho	Homo sapiens	219-225
23000190-1	2013	The vitamin D system plays a critical role in inflammatory bowel disease as evidenced by the finding that both vitamin D deficient mice and vitamin D receptor knockout mice are extremely sensitive to dextran sodium sulfate (DSS)-induced colitis.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	140-158
20394945-9	2010	Abnormal vitamin D metabolism is suggested as the mechanism, possibly involving defective up-regulation of the 24-hydroxylase by 1,25-(OH)2D3, and the klotho-FGF23 axis.	Vitamin D	9-18	klotho	Homo sapiens	151-157
20394945-9	2010	Abnormal vitamin D metabolism is suggested as the mechanism, possibly involving defective up-regulation of the 24-hydroxylase by 1,25-(OH)2D3, and the klotho-FGF23 axis.	Vitamin D	9-18	fibroblast growth factor 23	Homo sapiens	158-163
21073129-2	2010	Mutations in the VDR cause the rare genetic disease hereditary vitamin D resistant rickets (HVDRR).	Vitamin D	63-72	vitamin D receptor	Homo sapiens	17-20
23826116-1	2013	The vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
23805323-4	2013	We hypothesized that VDR expression, VDR level and transactivation of target genes, CAMP and CYP24A1, depend on vitamin D, ethnicity and FokI genotype.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	21-24
23805323-4	2013	We hypothesized that VDR expression, VDR level and transactivation of target genes, CAMP and CYP24A1, depend on vitamin D, ethnicity and FokI genotype.	Vitamin D	112-121	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	93-100
20647695-0	2010	Bone morphogenetic protein-7 inhibits vascular calcification induced by high vitamin D in mice.	Vitamin D	77-86	bone morphogenetic protein 7	Mus musculus	0-28
20647695-4	2010	We therefore tested the hypothesis that BMP-7 inhibits vascular calcification by using two conditions, high levels of vitamin D and phosphate, each of which could enhance vascular calcification.	Vitamin D	118-127	bone morphogenetic protein 7	Mus musculus	40-45
20647695-11	2010	Thus, BMP-7 inhibits vascular calcification associated with high levels of vitamin D or phosphate.	Vitamin D	75-84	bone morphogenetic protein 7	Mus musculus	6-11
23785369-1	2013	The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
20460683-0	2010	The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells.	Vitamin D	14-23	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	101-106
23169318-3	2013	We systemically evaluated the association of 89 tagging and candidate-based GSVs in six major vitamin D metabolism pathway genes (VDR, GC, CYP24A1, CYP27A1, CYP27B1 and CYP2R1) and the circulating serum vitamin D level with overall survival (OS) and second primary cancer (SPC) in 522 Stages I-II radiation-treated patients with HNC.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	130-133
23169318-3	2013	We systemically evaluated the association of 89 tagging and candidate-based GSVs in six major vitamin D metabolism pathway genes (VDR, GC, CYP24A1, CYP27A1, CYP27B1 and CYP2R1) and the circulating serum vitamin D level with overall survival (OS) and second primary cancer (SPC) in 522 Stages I-II radiation-treated patients with HNC.	Vitamin D	94-103	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	139-146
23362149-1	2013	When bound to the vitamin D receptor (VDR), the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is a potent regulator of osteoblast transcription.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	38-41
23426901-0	2013	Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget"s disease.	Vitamin D	39-48	TATA-box binding protein associated factor 12	Homo sapiens	13-18
20562186-1	2010	A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	213-231
23426901-7	2013	Chromatin immunoprecipitation (ChIP) analysis of OCL precursors using an anti-TAF12 antibody demonstrated that TAF12 binds the 24-hydroxylase (CYP24A1) promoter, which contains two functional vitamin D response elements (VDREs), in the presence of 1,25-(OH)2D3.	Vitamin D	192-201	TATA-box binding protein associated factor 12	Homo sapiens	111-116
23426901-7	2013	Chromatin immunoprecipitation (ChIP) analysis of OCL precursors using an anti-TAF12 antibody demonstrated that TAF12 binds the 24-hydroxylase (CYP24A1) promoter, which contains two functional vitamin D response elements (VDREs), in the presence of 1,25-(OH)2D3.	Vitamin D	192-201	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	143-150
23352876-1	2013	AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR).	Vitamin D	5-14	vitamin D receptor	Homo sapiens	151-169
20585181-5	2010	In patients undergoing dialysis, FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D therapy, which in turn cause hypophosphatemia and reduced 1,25-dihydroxyvitamin D after kidney transplantation.	Vitamin D	112-121	fibroblast growth factor 23	Homo sapiens	33-38
23352876-1	2013	AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR).	Vitamin D	5-14	vitamin D receptor	Homo sapiens	171-174
23352876-1	2013	AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR).	Vitamin D	95-104	vitamin D receptor	Homo sapiens	151-169
20868571-15	2010	Our results showed that low levels of vitamin D were associated with a decrease in Treg cells and a skewing of the Th1/Th2 balance towards Th1.	Vitamin D	38-47	negative elongation factor complex member C/D	Homo sapiens	115-118
23352876-1	2013	AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR).	Vitamin D	95-104	vitamin D receptor	Homo sapiens	171-174
23219444-10	2013	The genomic and epigenomic approach reinforce the crucial roles played by the DHCR7, CYP2R1, and CYP24A1 genes in vitamin D metabolism.	Vitamin D	114-123	7-dehydrocholesterol reductase	Homo sapiens	78-83
23219444-10	2013	The genomic and epigenomic approach reinforce the crucial roles played by the DHCR7, CYP2R1, and CYP24A1 genes in vitamin D metabolism.	Vitamin D	114-123	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	97-104
23423976-0	2013	CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.	Vitamin D	43-52	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
20868571-15	2010	Our results showed that low levels of vitamin D were associated with a decrease in Treg cells and a skewing of the Th1/Th2 balance towards Th1.	Vitamin D	38-47	negative elongation factor complex member C/D	Homo sapiens	139-142
20463051-8	2010	Thus, prolactin, by multiple mechanisms, including regulation of vitamin D metabolism, induction of TRPV6 mRNA, and cooperation with 1,25(OH)(2)D(3) in induction of intestinal calcium transport genes and intestinal calcium transport, can act as an important modulator of vitamin D-regulated calcium homeostasis.	Vitamin D	65-74	prolactin	Mus musculus	6-15
23221508-1	2013	BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] is a marker of nutritional status; however, chronic kidney disease (CKD) results in alterations in vitamin D metabolism, including the loss of vitamin D-binding proteins and alterations in CYP27B1 and CYP24 enzymes that metabolize 25(OH)D. This study was designed to determine the predictors of responsiveness to correction of vitamin D deficiency with oral vitamin D2 (ergocalciferol) in adults.	Vitamin D	22-31	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	243-248
20463051-8	2010	Thus, prolactin, by multiple mechanisms, including regulation of vitamin D metabolism, induction of TRPV6 mRNA, and cooperation with 1,25(OH)(2)D(3) in induction of intestinal calcium transport genes and intestinal calcium transport, can act as an important modulator of vitamin D-regulated calcium homeostasis.	Vitamin D	271-280	prolactin	Mus musculus	6-15
23703334-2	2013	Regulation of bone and mineral metabolism is a classic vitamin D effect, but the identification of the vitamin D receptor (VDR) in almost all human cells suggests a role for vitamin D also in extra-skeletal diseases.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	123-126
20138989-1	2010	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	128-146
23247634-0	2013	Vitamin D protects human endothelial cells from H2O2 oxidant injury through the Mek/Erk-Sirt1 axis activation.	Vitamin D	0-9	sirtuin 1	Homo sapiens	88-93
23247634-6	2013	Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2.	Vitamin D	19-28	sirtuin 1	Homo sapiens	87-93
20138989-1	2010	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	148-151
20138990-1	2010	Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	71-80	vitamin D receptor	Homo sapiens	0-18
20138990-1	2010	Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	71-80	vitamin D receptor	Homo sapiens	20-23
20138990-9	2010	In addition, they may contribute to the improvement of protocols for the clinical use of vitamin D compounds, as they indicate that advanced colon cancer patients overexpressing SNAIL1 and SNAIL2 are not suitable candidates for this therapy.	Vitamin D	89-98	snail family transcriptional repressor 2	Homo sapiens	189-195
23117582-1	2013	Fibroblast growth factor 23 (FGF23) is an "endocrine" FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1alpha hydroxylase and a stimulation of the 24 hydroxylase.	Vitamin D	132-141	fibroblast growth factor 23	Homo sapiens	0-27
20144713-0	2010	CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24.	Vitamin D	70-79	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	0-7
23117582-1	2013	Fibroblast growth factor 23 (FGF23) is an "endocrine" FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1alpha hydroxylase and a stimulation of the 24 hydroxylase.	Vitamin D	132-141	fibroblast growth factor 23	Homo sapiens	29-34
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	interleukin 10	Homo sapiens	281-286
20144713-8	2010	These results show that Cyp24a1 deficiency delays fracture repair and strongly suggest that vitamin D metabolites hydroxylated at position 24, such as 24,25(OH)2D3, play an important role in the mechanisms leading to normal fracture healing.	Vitamin D	92-101	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	24-31
20304059-2	2010	We developed a system for isolation of fresh endothelial cells from tumors and Matrigel environments which demonstrate that CYP24, the catabolic enzyme involved in vitamin D signaling, is epigenetically silenced selectively in tumor-derived endothelial cells (TDEC).	Vitamin D	164-173	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	124-129
20304061-2	2010	Vitamin D is thought to have both direct (through activation of the vitamin D receptor) and indirect (via regulation of calcium homeostasis) effects on various mechanisms related to the pathophysiology of both types of diabetes, including pancreatic beta-cell dysfunction, impaired insulin action and systemic inflammation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	68-86
23160722-0	2013	Vitamin D Receptor Fok-I polymorphism modulates diabetic host response to vitamin D intake: need for a nutrigenetic approach.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	0-18
23160722-11	2013	CONCLUSIONS: We concluded that those of VDR ff genotype may be regarded as "low responders" to vitamin D intake in terms of response of circulating 25(OH)D and certain inflammatory biomarkers.	Vitamin D	95-104	vitamin D receptor	Homo sapiens	40-43
20307661-0	2010	Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	45-48
20307661-0	2010	Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites.	Vitamin D	84-93	retinoid X receptor alpha	Homo sapiens	53-57
20307661-1	2010	The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	67-85
23370372-6	2013	Vitamin D acts on a number of cells involved in both innate and acquired immunity biasing the adaptive immune system away from Th17 and Th1, towards Th2 and Tregs.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	127-130
20307661-1	2010	The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	87-90
20307661-2	2010	VDR forms a heterodimer with the retinoid X receptors (RXRs) that when bound to ligand influences the transcriptional control of genes that regulate circulating levels of vitamin D metabolites.	Vitamin D	171-180	vitamin D receptor	Homo sapiens	0-3
23389957-2	2013	The active form of vitamin D [1alpha,25(OH)(2)D(3)] binds and activates its specific nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	107-125
23389957-2	2013	The active form of vitamin D [1alpha,25(OH)(2)D(3)] binds and activates its specific nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-130
20359533-0	2010	Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality.	Vitamin D	0-9	ADAM metallopeptidase domain 17	Homo sapiens	24-28
23735022-8	2013	Two theories try to explain this origin of low BMD: Micronutrients malabsorption (including calcium and vitamin D) determined by villous atrophy has been related to secondary hyperparathyroidism and incapacity to achieve the potential bone mass peak; chronic inflammation was also related with RANKL secretion, osteoclasts activation and increased bone resorption.	Vitamin D	104-113	TNF superfamily member 11	Homo sapiens	294-299
20398751-2	2010	The unbalanced high levels of CYP24A1 seem to be a determinant of vitamin D resistance in tumors.	Vitamin D	66-75	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
20398755-7	2010	In conclusion, the -1012 VDRp genotype appears to be associated with height in European children whatever their calcium/dairy product intakes, and may modulate their calcium homeostasis in conditions of low calcium/milk intakes when vitamin D status is sufficient.	Vitamin D	233-242	vitamin D receptor	Homo sapiens	25-29
23393347-2	2013	The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue.	Vitamin D	21-30	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	47-54
20637153-1	2010	OBJECTIVE: To study the correlation between vitamin D receptor genetic polymorphism Fokand vitamin D deficiency rickets in children between 1 to 3 years old, and to explore the significance of hereditary factors in the development of vitamin D deficiency rickets.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	44-62
23393347-2	2013	The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	110-128
23393347-2	2013	The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	130-133
20357029-6	2010	The main findings were as follow: 1) FGF23-dependent phosphaturic activity in Npt2a KO mice is dependent on renal Npt2c and PiT-2 protein; 2) in DKO mice, renal P(i) reabsorption is not further decreased by FGF23M, but renal vitamin D synthesis is suppressed; and 3) downregulation of intestinal Npt2b may be mediated by a factor(s) other than 1,25(OH)(2)D(3).	Vitamin D	225-234	fibroblast growth factor 23	Mus musculus	37-42
20511050-1	2010	The actions of the vitamin D hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	102-120
22763025-2	2013	Vitamin D receptor occurs in different tissues, and several cells other than renal cells are able to locally produce active vitamin D, which is responsible for transcriptional control of hundreds of genes related to its pleiotropic effects.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	0-18
22740316-8	2013	The downregulated 24-hydroxylase (Cyp24a1) gene expression in femoral bone indicated local vitamin D resistance in the mice treated with ZK191784.	Vitamin D	91-100	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	34-41
20511050-1	2010	The actions of the vitamin D hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	122-125
20511055-5	2010	When the VDR is defective, the disease hereditary vitamin D-resistant rickets, also known as vitamin D-dependent rickets type 2, develops.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	9-12
23334593-7	2013	In primary human astrocytes in vitro, the active form of vitamin D, 1,25(OH)(2)D(3), induced upregulation of VDR and CYP24A1.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	109-112
20511055-5	2010	When the VDR is defective, the disease hereditary vitamin D-resistant rickets, also known as vitamin D-dependent rickets type 2, develops.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	9-12
23334593-7	2013	In primary human astrocytes in vitro, the active form of vitamin D, 1,25(OH)(2)D(3), induced upregulation of VDR and CYP24A1.	Vitamin D	57-66	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
20515752-8	2010	Our proteomic approach identified increased levels of vitamin D-binding protein precursor (VDB) in the serum of STEMI patients when compared to control donors.	Vitamin D	54-63	GC vitamin D binding protein	Homo sapiens	91-94
23334593-9	2013	Increased VDR expression in MS NAWM and inflammatory cytokine-induced amplified expression of VDR and CYP27B1 in chronic active MS lesions suggest increased sensitivity to vitamin D in NAWM and a possible endogenous role for vitamin D metabolism in the suppression of active MS lesions.	Vitamin D	172-181	vitamin D receptor	Homo sapiens	10-13
23334593-9	2013	Increased VDR expression in MS NAWM and inflammatory cytokine-induced amplified expression of VDR and CYP27B1 in chronic active MS lesions suggest increased sensitivity to vitamin D in NAWM and a possible endogenous role for vitamin D metabolism in the suppression of active MS lesions.	Vitamin D	172-181	vitamin D receptor	Homo sapiens	94-97
20420906-1	2010	The vitamin D receptor (VDR) typically binds DNA in a heterodimer complex with the retinoid X receptor (RXR) to direct repeat sequences separated by three base pairs, or vitamin D response elements (VDREs).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
23356636-9	2013	The analysis of CCT data identified vitamin D as a promising caries-preventive agent, leading to a low-certainty conclusion that vitamin D may reduce the incidence of caries.	Vitamin D	36-45	CCT	Homo sapiens	16-19
20420906-1	2010	The vitamin D receptor (VDR) typically binds DNA in a heterodimer complex with the retinoid X receptor (RXR) to direct repeat sequences separated by three base pairs, or vitamin D response elements (VDREs).	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	83-102
23178257-4	2013	Thus, vitamin D signaling primarily implies the molecular actions of the VDR.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	73-76
20420906-1	2010	The vitamin D receptor (VDR) typically binds DNA in a heterodimer complex with the retinoid X receptor (RXR) to direct repeat sequences separated by three base pairs, or vitamin D response elements (VDREs).	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	104-107
20592360-2	2010	The antiproliferative effects of calcitriol (1,25(OH)(2)D(3)) mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	99-102
23160964-7	2013	These data demonstrate that 1,25-dihydroxyvitamin D stimulates adipose leptin production in a VDR-dependent manner, suggesting that vitamin D may affect energy homeostasis through direct regulation of leptin expression.	Vitamin D	42-51	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	94-97
23392891-3	2013	In this study, we test the hypothesis that the TauT gene is regulated by vitamin D(3) (VD(3)) and retinoic acid (RA) via activation of the vitamin D receptor (VDR) and retinoic acid receptor (RXR).	Vitamin D	73-82	vitamin D receptor	Homo sapiens	139-157
23392891-3	2013	In this study, we test the hypothesis that the TauT gene is regulated by vitamin D(3) (VD(3)) and retinoic acid (RA) via activation of the vitamin D receptor (VDR) and retinoic acid receptor (RXR).	Vitamin D	73-82	vitamin D receptor	Homo sapiens	159-162
23392891-3	2013	In this study, we test the hypothesis that the TauT gene is regulated by vitamin D(3) (VD(3)) and retinoic acid (RA) via activation of the vitamin D receptor (VDR) and retinoic acid receptor (RXR).	Vitamin D	73-82	retinoid X receptor alpha	Homo sapiens	192-195
20090765-0	2010	Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.	Vitamin D	108-117	kallikrein related peptidase 4	Homo sapiens	0-10
23094920-5	2013	Analytic epidemiologic studies of vitamin D and prostate cancer have focused on polymorphisms in the vitamin D receptor (VDR), on serum vitamin D levels, and on solar exposure.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	101-119
20435872-7	2010	The majority of circulating vitamin D is bound to VDBP, and its uptake into cells occurs in both bound and unbound forms, which suggests the role of VDBP warrants further study in these conditions as well.	Vitamin D	28-37	GC vitamin D binding protein	Homo sapiens	50-54
23094920-5	2013	Analytic epidemiologic studies of vitamin D and prostate cancer have focused on polymorphisms in the vitamin D receptor (VDR), on serum vitamin D levels, and on solar exposure.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	121-124
23094920-5	2013	Analytic epidemiologic studies of vitamin D and prostate cancer have focused on polymorphisms in the vitamin D receptor (VDR), on serum vitamin D levels, and on solar exposure.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	121-124
20435872-7	2010	The majority of circulating vitamin D is bound to VDBP, and its uptake into cells occurs in both bound and unbound forms, which suggests the role of VDBP warrants further study in these conditions as well.	Vitamin D	28-37	GC vitamin D binding protein	Homo sapiens	149-153
23724632-0	2013	Vitamin D status in female students and its relation to calcium metabolism markers, lifestyles, and polymorphism in vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	116-134
20960270-6	2010	Unexpectedly, alendronate at 10-7 and 10-5 M concentrations increased the RANKL expression with the presence of vitamin D in differentiated hOB, and this induction of RANKL mRNA levels by alendronate was dose-dependent.	Vitamin D	112-121	TNF superfamily member 11	Homo sapiens	74-79
23724632-3	2013	The aim of this study was to evaluate the prevalence of vitamin D deficiency and its relation with vitamin D receptor (VDR) gene polymorphism.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	99-117
23724632-3	2013	The aim of this study was to evaluate the prevalence of vitamin D deficiency and its relation with vitamin D receptor (VDR) gene polymorphism.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	119-122
23724632-9	2013	There was a significant relationship between serum levels of vitamin D with ionized Ca, PTH, ALP, type of clothing, and egg consumption, while no significant relationship was found between serum levels of vitamin D with age, residency, menstruation status, skin color, sun light exposure, body mass index, waist to hip ratio, exercise, physical activity, fish consumption, and polymorphisms in exon 9 of VDR gene.	Vitamin D	61-70	ATHS	Homo sapiens	93-96
23206185-2	2013	Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism.	Vitamin D	164-173	fibroblast growth factor 23	Homo sapiens	0-27
20960270-8	2010	Thus, we conclude that alendronate does not affect the ALP activity and OPG gene expression in differentiated hOB, but may increase RANKL gene expression induced by vitamin D.	Vitamin D	165-174	TNF superfamily member 11	Homo sapiens	132-137
20043299-1	2010	The activity of beta-catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon.	Vitamin D	96-105	vitamin D receptor	Homo sapiens	116-119
22986488-3	2013	While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals.	Vitamin D	139-148	fibroblast growth factor 23	Homo sapiens	169-175
22986488-4	2013	This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human.	Vitamin D	70-79	fibroblast growth factor 23	Homo sapiens	136-142
19626341-2	2010	When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance.	Vitamin D	165-174	fibroblast growth factor 23	Homo sapiens	29-56
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	10-19	tripartite motif containing 27	Homo sapiens	93-99
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	10-19	centrin 3	Homo sapiens	123-128
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	55-64	tripartite motif containing 27	Homo sapiens	93-99
23527013-9	2013	Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified.	Vitamin D	55-64	centrin 3	Homo sapiens	123-128
19626341-2	2010	When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance.	Vitamin D	165-174	fibroblast growth factor 23	Homo sapiens	58-63
20363711-8	2010	Vitamin D deficiency is widespread in the older adult population as a result of low dietary intake, decreased sun exposure, decreased intrinsic vitamin D production, and decreased vitamin D receptor activity.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	180-198
23544077-4	2013	Since vitamin D performs its function by binding the receptor encoded by the vitamin D-receptor gene (VDR), most studies have focused on polymorphisms (SNPs) within this gene.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	77-95
23544077-4	2013	Since vitamin D performs its function by binding the receptor encoded by the vitamin D-receptor gene (VDR), most studies have focused on polymorphisms (SNPs) within this gene.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	102-105
23326564-0	2013	Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.	Vitamin D	41-50	CD44 molecule (Indian blood group)	Homo sapiens	10-14
23326564-2	2013	We have previously demonstrated that the novel Gemini vitamin D analog BXL0124 [1alpha,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluro-cholecalciferol] repressed CD44 expression in MCF10DCIS.com basal-like human breast cancer cells and inhibited MCF10DCIS xenograft tumor growth.	Vitamin D	54-63	CD44 molecule (Indian blood group)	Homo sapiens	206-210
23326564-4	2013	METHODS AND FINDINGS: The treatment with Gemini vitamin D BXL0124 decreased CD44 protein level, suppressed STAT3 signaling, and inhibited invasion and proliferation of MCF10DCIS cells.	Vitamin D	48-57	CD44 molecule (Indian blood group)	Homo sapiens	76-80
23326564-12	2013	It also suggests that repression of CD44-STAT3 signaling is a key molecular mechanism in the inhibition of breast cancer invasion by the Gemini vitamin D analog BXL0124.	Vitamin D	144-153	CD44 molecule (Indian blood group)	Homo sapiens	36-40
24455835-6	2013	Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients.	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	192-196
19931390-4	2010	Fibroblasts transfected with a vitamin D response element-reporter construct and exposed to the active vitamin D metabolite, 1,25(OH)(2)D(3), showed increased promoter activity indicating VDR functionality in these cells.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	188-191
24455835-6	2013	Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	199-217
24455835-6	2013	Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	224-227
19931390-4	2010	Fibroblasts transfected with a vitamin D response element-reporter construct and exposed to the active vitamin D metabolite, 1,25(OH)(2)D(3), showed increased promoter activity indicating VDR functionality in these cells.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	188-191
19952276-7	2010	1,25-Dihydroxyvitamin D levels, reduced in HYP mice, were comparably elevated in Klotho and Klotho/HYP mice, demonstrating that Klotho is necessary for FGF23"s effect on vitamin D metabolism.	Vitamin D	14-23	fibroblast growth factor 23	Mus musculus	152-157
23076388-12	2013	Vitamin-D deficient patients had, however, higher levels of Vitamin-D Binding Protein in sputum sol.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	60-85
19885846-2	2010	Vitamin D(3) binds to the vitamin D(3) receptor (VDR), a member of the superfamily of nuclear receptors, which in turn interacts with transcriptional activators to target this regulatory complex to specific sequence elements within gene promoters.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	26-47
24358453-4	2013	In particular, we note an interesting link between vitamin D/VDR signaling and tissue barriers.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	61-64
23074218-0	2012	Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes.	Vitamin D	0-9	cystathionine gamma-lyase	Homo sapiens	103-128
23074218-0	2012	Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes.	Vitamin D	0-9	cystathionine gamma-lyase	Homo sapiens	130-133
19885846-2	2010	Vitamin D(3) binds to the vitamin D(3) receptor (VDR), a member of the superfamily of nuclear receptors, which in turn interacts with transcriptional activators to target this regulatory complex to specific sequence elements within gene promoters.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	49-52
19885846-4	2010	Previous reports indicated that the VDR exhibits a punctate nuclear distribution that is significantly enhanced in cells grown in the presence of vitamin D(3).	Vitamin D	146-155	vitamin D receptor	Homo sapiens	36-39
19885846-6	2010	This interaction of VDR with the nuclear matrix occurs rapidly after vitamin D(3) addition and does not require a functional VDR DNA-binding domain.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	20-23
23217254-2	2012	With emphasis on human metabolism, we critically review current data, and propose that--although a number of questions remain--circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation.	Vitamin D	188-197	fibroblast growth factor 23	Homo sapiens	139-144
19885846-8	2010	Together these results indicate that after ligand stimulation the VDR rapidly enters the nucleus and associates with the nuclear matrix preceding vitamin D(3)-transcriptional upregulation.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	66-69
19965919-1	2010	CONTEXT: Fibroblast growth factor 23 (FGF23) regulates phosphorus homeostasis and vitamin D metabolism.	Vitamin D	82-91	fibroblast growth factor 23	Homo sapiens	9-36
22358381-1	2012	We aimed to study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-gamma, which play an important role in the immune response of patients with allergic rhinitis and/or nasal polyps, and determine the correlation between Th1/Th2 cell balance and 1alpha,25-dihydroxyvitamin D(3), an active metabolite of vitamin D.	Vitamin D	294-303	negative elongation factor complex member C/D	Homo sapiens	18-21
23203019-3	2012	demonstrate that administration of active vitamin D and its analog decreases aortic calcification in association with increases in two potent calcification inhibitors--the secreted form of Klotho and vascular osteopontin.	Vitamin D	42-51	klotho	Homo sapiens	189-195
19965919-1	2010	CONTEXT: Fibroblast growth factor 23 (FGF23) regulates phosphorus homeostasis and vitamin D metabolism.	Vitamin D	82-91	fibroblast growth factor 23	Homo sapiens	38-43
19783860-4	2010	VDR, CYP27B1 or CYP2R1 gene variants could modify the biological activity of vitamin D(3).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	0-3
22903070-1	2012	Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	182-200
19837082-2	2010	In an activity-guided approach using reporter gene assays where the distal part of the 5-LO gene was included in the reporter gene plasmid, we localized vitamin D response elements (VDREs) within exon 10, exon 12, and intron M. We found that these newly identified VDRE sites are bound by vitamin D receptor both in vitro by gel-shift analysis and in vivo by chromatin immunoprecipitation assays.	Vitamin D	153-162	vitamin D receptor	Homo sapiens	289-307
22921867-1	2012	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D.	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	0-27
19948723-1	2010	Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator of innate immunity in humans.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	40-58
22921867-1	2012	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D.	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	29-34
20059333-2	2010	Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels.	Vitamin D	151-160	fibroblast growth factor 23	Homo sapiens	0-27
23055531-5	2012	A functional vitamin D response element was defined in the 5-prime regulatory region of the miR-498 genome, which is occupied by the vitamin D receptor and its coactivators.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	133-151
22884583-5	2012	We found that overexpression of PPARgamma decreased 1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) mediated transcriptional activity of the vitamin D target gene, CYP24A1, by 49% and the activity of VDRE-luc, a vitamin D responsive reporter, by 75% in T47D human breast cancer cells.	Vitamin D	71-80	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	159-166
20059333-2	2010	Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels.	Vitamin D	151-160	fibroblast growth factor 23	Homo sapiens	29-34
22884583-5	2012	We found that overexpression of PPARgamma decreased 1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) mediated transcriptional activity of the vitamin D target gene, CYP24A1, by 49% and the activity of VDRE-luc, a vitamin D responsive reporter, by 75% in T47D human breast cancer cells.	Vitamin D	136-145	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	159-166
19965548-0	2010	Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD.	Vitamin D	46-55	fibroblast growth factor 23	Homo sapiens	59-64
23012375-4	2012	Vitamin D-sufficient patients (&gt;=30 ng/ml 25(OH)D) had lower monocyte endoplasmic reticulum (ER) stress, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of monocyte adhesion molecules PSGL-1, beta(1)-integrin, and beta(2)-integrin compared with patients with 25(OH)D levels of &lt;30 ng/ml.	Vitamin D	0-9	integrin subunit beta 1	Homo sapiens	237-253
22892281-2	2012	Most known effects of vitamin D are mediated via the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	53-71
20055894-7	2010	Vitamin D stimulated CYP24A, BGLAP and TNFSF11 expression in hOB and these effects were modified by nontoxic LCA concentrations.	Vitamin D	0-9	TNF superfamily member 11	Homo sapiens	39-46
22892281-2	2012	Most known effects of vitamin D are mediated via the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	73-76
20055894-8	2010	LCA significantly decreased vitamin D stimulation of CYP24A, BGLAP and TNFSF11 gene expression at 72%, 79% and 56% (respectively).	Vitamin D	28-37	TNF superfamily member 11	Homo sapiens	71-78
20055894-11	2010	CONCLUSIONS: Lithocholic acid decreases the stimulatory effect of vitamin D on CYP24A, BGLAP and TNFSF11 expression in hOB.	Vitamin D	66-75	TNF superfamily member 11	Homo sapiens	97-104
22103239-1	2012	UNLABELLED: Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	12-39
20055894-12	2010	This effect is produced through vitamin D response elements (VDREs), located in the promoter regions of these genes, suggesting that LCA acts as a mild analogous of vitamin D, interacting with the vitamin D receptor.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	197-215
22103239-1	2012	UNLABELLED: Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	41-46
20055894-12	2010	This effect is produced through vitamin D response elements (VDREs), located in the promoter regions of these genes, suggesting that LCA acts as a mild analogous of vitamin D, interacting with the vitamin D receptor.	Vitamin D	165-174	vitamin D receptor	Homo sapiens	197-215
20731116-3	2010	FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations.	Vitamin D	132-141	fibroblast growth factor 23	Homo sapiens	0-6
22692397-8	2012	In this article, we review the aspects related to the metabolism and immunoregulatory effects of vitamin D, VDR, and main polymorphisms involving the VDR gene and the relationship between vitamin D levels and its receptor with SLE.	Vitamin D	188-197	vitamin D receptor	Homo sapiens	150-153
19724293-4	2009	Impairment of cooperative signalling from the 1,25-(OH)(2)D(3)-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	93-96
22664272-9	2012	Furthermore, strong VDR expression in Barrett"s mucosa may indicate an increased sensitivity of this tissue to endogenous or therapeutic effects of Vitamin D.	Vitamin D	148-157	vitamin D receptor	Homo sapiens	20-23
23450267-1	2012	The bioactive form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 (1alpha, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	128-146
23450267-1	2012	The bioactive form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 (1alpha, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	148-151
19900346-4	2009	Vitamin D is most well known for its role in bone health; however, the discovery of VDR on a wide variety of tissue types has also opened up roles for vitamin D far beyond traditional bone health.	Vitamin D	151-160	vitamin D receptor	Homo sapiens	84-87
22634121-4	2012	Vitamin D deficiency is frequently present in chronic liver disease and may predict non-response to antiviral therapy in chronic hepatitis C. Small studies suggest that vitamin D supplementation improves sustained viral response rates, while 1alpha-hydroxylase polymorphisms and vitamin D-binding protein are also implicated in therapeutic outcomes.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	279-304
22564762-2	2012	Among the PIAS proteins evaluated, we establish PIAS4 as a potent inhibitor of the transcriptional responses of the CYP3A4 and CYP24A1 target genes to the active hormonal form of vitamin D, a repression that was observed to be dependent upon an intact SUMO-ligase function of PIAS4.	Vitamin D	179-188	protein inhibitor of activated STAT 4	Homo sapiens	48-53
22564762-2	2012	Among the PIAS proteins evaluated, we establish PIAS4 as a potent inhibitor of the transcriptional responses of the CYP3A4 and CYP24A1 target genes to the active hormonal form of vitamin D, a repression that was observed to be dependent upon an intact SUMO-ligase function of PIAS4.	Vitamin D	179-188	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	127-134
22564762-2	2012	Among the PIAS proteins evaluated, we establish PIAS4 as a potent inhibitor of the transcriptional responses of the CYP3A4 and CYP24A1 target genes to the active hormonal form of vitamin D, a repression that was observed to be dependent upon an intact SUMO-ligase function of PIAS4.	Vitamin D	179-188	protein inhibitor of activated STAT 4	Homo sapiens	276-281
19861519-2	2009	Common polymorphisms in the vitamin D receptor (VDR) are associated with VDR activity and are therefore potentially useful proxies for assessing whether vitamin D is causally related to advanced prostate cancer.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	48-51
22564762-4	2012	Our results implicate PIAS4 and the process of SUMOylation as important modulators of VDR-mediated signaling which may both represent flexible mechanistic components as to how vitamin D achieves its pleiotropic effects.	Vitamin D	176-185	protein inhibitor of activated STAT 4	Homo sapiens	22-27
22564762-4	2012	Our results implicate PIAS4 and the process of SUMOylation as important modulators of VDR-mediated signaling which may both represent flexible mechanistic components as to how vitamin D achieves its pleiotropic effects.	Vitamin D	176-185	vitamin D receptor	Homo sapiens	86-89
19861519-2	2009	Common polymorphisms in the vitamin D receptor (VDR) are associated with VDR activity and are therefore potentially useful proxies for assessing whether vitamin D is causally related to advanced prostate cancer.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	73-76
19770756-2	2009	RECENT FINDINGS: FGF23 regulates phosphorus and vitamin D metabolism.	Vitamin D	48-57	fibroblast growth factor 23	Homo sapiens	17-22
22626544-9	2012	Identification of novel heart VIPs and their influence on VDR activity may increase our understanding of how vitamin D impacts cardiac physiology and may facilitate development of VDR/VIP drug analogs to combat heart disease.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	58-61
22476084-1	2012	The vitamin D receptor (VDR), an evolutionarily conserved member of the nuclear receptor superfamily, links the metabolically activated vitamin D ligand, calcitriol, with its vitamin D-responsive target genes that are implicated in diverse physiological processes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
22476084-1	2012	The vitamin D receptor (VDR), an evolutionarily conserved member of the nuclear receptor superfamily, links the metabolically activated vitamin D ligand, calcitriol, with its vitamin D-responsive target genes that are implicated in diverse physiological processes.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	4-22
22476084-1	2012	The vitamin D receptor (VDR), an evolutionarily conserved member of the nuclear receptor superfamily, links the metabolically activated vitamin D ligand, calcitriol, with its vitamin D-responsive target genes that are implicated in diverse physiological processes.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	24-27
22476084-5	2012	As further support that this novel interactor might be involved in vitamin D-stimulated transcriptional regulation, we demonstrate that VDR and DDX5 co-localize within the nuclei of HaCaT keratinocytes and sub-cellular protein fractions.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	136-139
19941273-3	2009	Vitamin D is a hormone whose actions take place through a specific receptor, the vitamin D receptor (VDR), which is ubiquitous.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	81-99
19941273-3	2009	Vitamin D is a hormone whose actions take place through a specific receptor, the vitamin D receptor (VDR), which is ubiquitous.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	101-104
19941276-5	2009	The use of VDR activators to treat these and other parameters outside of cardiovascular and renal disease not only results in enhanced patient health but significantly lowers the risk of mortality in CKD and non-CKD patients with low systemic activity of vitamin D.	Vitamin D	255-264	vitamin D receptor	Homo sapiens	11-14
22920700-1	2012	INTRODUCTION: Vitamin D is responsible for the regulation of certain genes at the transcription level, via interaction with the vitamin D receptor, and influences host immune responses and aspects of bone development, growth, and homeostasis.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	128-146
19829313-3	2009	Definition of the adequate amount of vitamin D, however, is still uncertain; polymorphisms of the gene encoding the vitamin D receptor might be responsible for this uncertainty.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	116-134
22751936-7	2012	At first, possible differences in the expression             of CYP24A1, a major catabolizing enzyme for vitamin D compounds and resulting             differences in the degradation of analogs were investigated.	Vitamin D	105-114	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	64-71
19844248-2	2009	The endocrine actions of FGF23, in association with parathyroid hormone and vitamin D, mobilize sodium-phosphate cotransporters that control renal phosphate transport in proximal tubular epithelial cells.	Vitamin D	76-85	fibroblast growth factor 23	Homo sapiens	25-30
22648952-2	2012	However, there has been some controversy about the expression of the vitamin D receptor (VDR) and thus the potential role of vitamin D(3) in skeletal muscle.	Vitamin D	69-78	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	89-92
22537546-10	2012	EAT from vitamin D-deficient group had significantly higher expression of TNF-alpha, IL-6, MCP-1, and decreased adiponectin in association with increased inflammatory cellular infiltrate.	Vitamin D	9-18	C-C motif chemokine 2	Sus scrofa	91-96
22537546-10	2012	EAT from vitamin D-deficient group had significantly higher expression of TNF-alpha, IL-6, MCP-1, and decreased adiponectin in association with increased inflammatory cellular infiltrate.	Vitamin D	9-18	adiponectin, C1Q and collagen domain containing	Sus scrofa	112-123
19844248-5	2009	Several factors, including phosphate and vitamin D, can regulate the production of both FGF23 and Klotho and influence their functions.	Vitamin D	41-50	fibroblast growth factor 23	Homo sapiens	88-93
22537547-0	2012	Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	49-52
19844248-5	2009	Several factors, including phosphate and vitamin D, can regulate the production of both FGF23 and Klotho and influence their functions.	Vitamin D	41-50	klotho	Homo sapiens	98-104
22537547-12	2012	There was significantly increased expression of TNF-alpha and decreased expression of VDR and prohibitin in the lung of vitamin D-deficient mouse model of allergic airway inflammation.	Vitamin D	120-129	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	86-89
19787215-3	2009	Vitamin D, which works through binding the vitamin D receptor (VDR) has an important role in cancer progression and immune response.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-61
22564539-1	2012	PURPOSE: The anti-proliferative effects of 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3), calcitriol, the active form of vitamin D) are mediated by the nuclear vitamin D receptor (VDR).	Vitamin D	62-71	vitamin D receptor	Homo sapiens	157-175
22564539-1	2012	PURPOSE: The anti-proliferative effects of 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3), calcitriol, the active form of vitamin D) are mediated by the nuclear vitamin D receptor (VDR).	Vitamin D	62-71	vitamin D receptor	Homo sapiens	177-180
22306846-3	2012	Given that VDR is the major mediator for vitamin D"s actions, we sought to clarify the role of VDR in late-onset AD.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	11-14
19787215-3	2009	Vitamin D, which works through binding the vitamin D receptor (VDR) has an important role in cancer progression and immune response.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	63-66
19615945-7	2009	Vitamin D(3) significantly reduced the MMP-7 (p=0.0001) and MMP-9 (p=0.0001) and increased the TIMP-1 (p=0.005) level in antigen stimulated and unstimulated cultures of PTB as compared to HC.	Vitamin D	0-9	matrix metallopeptidase 9	Homo sapiens	60-65
20021806-0	2009	[Effect of vitamin D supplementation in early life on the expression of interleukin-10 and intercellular adhesion molecule-1 in rat asthma model].	Vitamin D	11-20	intercellular adhesion molecule 1	Rattus norvegicus	91-124
22503810-1	2012	The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
19748465-3	2009	We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5.	Vitamin D	27-36	beclin 1	Homo sapiens	194-202
22503810-3	2012	To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	141-144
22503810-3	2012	To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets.	Vitamin D	213-222	vitamin D receptor	Homo sapiens	141-144
19667166-6	2009	Thus, impairment of antimitogenic, proapoptotic and prodifferentiating signaling from the 1,25(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency has been implicated in the pathogenesis of the aforementioned types of cancer.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	132-135
19667166-7	2009	1,25(OH)2D3 and calcium interact in modulating cell growth in different ways: (i) Signaling pathways from the VDR and the CaR converge on the same downstream elements, e.g. of the canonical Wnt pathway; (ii) high extracellular calcium modulates extrarenal vitamin D metabolism in favor of higher local steady-state concentrations of 1,25(OH)2D3; (iii) 1,25(OH)2D3 may up-regulate expression of the CaR and thus augment CaR-mediated antiproliferative responses to high extracellular Ca2+.	Vitamin D	256-265	vitamin D receptor	Homo sapiens	110-113
22576141-3	2012	An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	41-44
19706847-1	2009	Genetic association studies investigating the role of vitamin D in colon cancer have primarily focused on the vitamin D receptor (VDR), with limited data available for other genes in the vitamin D pathway, including vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1).	Vitamin D	110-119	vitamin D receptor	Homo sapiens	130-133
22704802-13	2012	The decreased expression and the genetic effect of VDBP in RA suggest a novel pathogenic pathway that vitamin D contributes to the arthritic process of the disease.	Vitamin D	102-111	GC vitamin D binding protein	Homo sapiens	51-55
19706847-1	2009	Genetic association studies investigating the role of vitamin D in colon cancer have primarily focused on the vitamin D receptor (VDR), with limited data available for other genes in the vitamin D pathway, including vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1).	Vitamin D	110-119	vitamin D receptor	Homo sapiens	130-133
19702932-2	2009	In bone cells, the vitamin D receptor (VDR) and the steroid and xenobiotic receptor (SXR) are activated by vitamin D and vitamin K2, respectively.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	39-42
22460930-6	2012	TRIP-1 levels were decreased with dexamethasone and increased with vitamin D(3) , dihydrotestosterone (DHT), TGFbeta1, and bone morphogenic protein 2 (BMP-2).	Vitamin D	67-76	eukaryotic translation initiation factor 3 subunit I	Homo sapiens	0-6
19364661-5	2009	The physiological buffer for vitamin D safety is the capacity of plasma vitamin D-binding protein to bind the total of circulating 25(OH)D, vitamin D, and 1,25-dihydroxyvitamin D [1,25(OH)2D].	Vitamin D	29-38	GC vitamin D binding protein	Homo sapiens	72-97
22211698-5	2012	The enhanced production of CXCL1 was suppressed by 1alpha, 24R-dihydroxyvitamin D(3) , an active form of vitamin D(3) , and weakly by glucocorticoids, dexamethasone and clobetasol propionate, whereas production of CXCL8 was not altered by any of those receptor agonists.	Vitamin D	72-81	C-X-C motif chemokine ligand 1	Homo sapiens	27-32
22211698-7	2012	These results suggest that the IL-17-induced pro-inflammatory reaction is enhanced by the activation of PAR2 in keratinocytes, and that the effect of PAR2 is differentially modulated by cyclosporine A, the active form of vitamin D(3)  and glucocorticoids.	Vitamin D	221-230	interleukin 17A	Homo sapiens	31-36
19364661-6	2009	Hypercalcemia occurs when the free concentration is inappropriately high because vitamin D and its other metabolites have displaced 1,25(OH)2D from vitamin D-binding protein.	Vitamin D	81-90	GC vitamin D binding protein	Homo sapiens	148-173
19393200-8	2009	Emerging molecular evidence suggests that symptomatic improvements among those administered vitamin D is the result of 25-D"s ability to temper bacterial-induced inflammation by slowing VDR activity.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	186-189
21956771-10	2012	These results highlight the role of the vitamin D axis in chronic kidney disease, an axis which includes vitamin D, its receptor and vitamin D-binding protein-derived GcMAF.	Vitamin D	40-49	GC vitamin D binding protein	Homo sapiens	167-172
19500727-1	2009	Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23).	Vitamin D	17-26	klotho	Mus musculus	137-143
19500727-1	2009	Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23).	Vitamin D	17-26	fibroblast growth factor 23	Mus musculus	148-175
19500727-1	2009	Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23).	Vitamin D	17-26	fibroblast growth factor 23	Mus musculus	177-183
19269107-2	2009	A low vitamin D status has now been linked to several Th1-mediated autoimmune diseases, including multiple sclerosis, type 1 diabetes and rheumatoid arthritis, with the strongest evidence for the vitamin"s protective role in multiple sclerosis.	Vitamin D	6-15	negative elongation factor complex member C/D	Homo sapiens	54-57
19269107-3	2009	Sunlight and vitamin D may be potent immunomodulatory agents by down-regulating Th1-driven immune responses and inducing the synthesis of antimicrobial peptides considered as natural antibiotics of the immune system.	Vitamin D	13-22	negative elongation factor complex member C/D	Homo sapiens	80-83
19393206-5	2009	We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	38-41
19393206-5	2009	We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	38-41
19522996-2	2009	Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes.	Vitamin D	53-62	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	189-197
19018272-7	2009	CONCLUSIONS: These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	122-125
19225558-7	2009	These in vivo studies suggest that vitamin D has a pathologic role in regulating abnormal mineral ion metabolism and soft-tissue anomalies of klotho-deficient mice.	Vitamin D	35-44	klotho	Mus musculus	142-148
19237542-1	2009	Plasma concentrations of biologically active vitamin D (1,25-(OH)(2)D) are tightly controlled via feedback regulation of renal 1alpha-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.	Vitamin D	45-54	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	186-193
19237542-10	2009	Gene expression analysis confirmed a reduced capacity for CYP24A1 induction with promoter methylation in primary cells and in vitro reporter analysis demonstrated that promoter methylation directly down-regulates basal promoter activity and abolishes vitamin D-mediated feedback activation.	Vitamin D	251-260	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	58-65
19414758-10	2009	The in vivo expansion of Ag-specific Treg with the topical application of the vitamin D analog calcipotriol followed by transcutaneous immunization is a simple method to augment functional Ag-specific CD4(+)CD25(+)Foxp3(+) Treg populations and mimics Ag-specific UV-induced tolerance.	Vitamin D	78-87	CD4 antigen	Mus musculus	201-204
19321461-12	2009	Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.	Vitamin D	20-29	interleukin 10	Homo sapiens	58-63
19321461-12	2009	Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.	Vitamin D	20-29	interleukin 17A	Homo sapiens	116-121
19357251-1	2009	Fibroblast growth factor-23 (FGF23), a hormone central to phosphate and vitamin D metabolism, reduces renal absorption of phosphate by downregulating the sodium-phosphate cotransporter Npt2a.	Vitamin D	72-81	fibroblast growth factor 23	Mus musculus	0-27
19357251-1	2009	Fibroblast growth factor-23 (FGF23), a hormone central to phosphate and vitamin D metabolism, reduces renal absorption of phosphate by downregulating the sodium-phosphate cotransporter Npt2a.	Vitamin D	72-81	fibroblast growth factor 23	Mus musculus	29-34
19386033-5	2009	However, sufficient evidence is available to warrant larger epidemiologic studies that should aim to identify possible interactions between VDR polymorphisms and vitamin D status.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	140-143
19383117-3	2009	PRESENTATION OF THE HYPOTHESIS: We hypothesize that low availability of 1,25-dihydroxyvitamin D, either due to vitamin D deficiency or due to polymorphisms in the vitamin D receptor or in its activating/inactivating enzymes, contributes to the appearance of IRIS.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	163-181
19299728-1	2009	The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP).	Vitamin D	19-28	dermcidin	Homo sapiens	146-150
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	12-21	dermcidin	Homo sapiens	268-272
19299728-7	2009	Under these vitamin D "insufficient" conditions the TLR2/1 ligand 19 kDa lipopeptide or the TLR4 ligand LPS, monocytes showed increased expression of the vitamin D-activating enzyme CYP27b1 (5- and 5.5-fold, respectively, both p &lt; 0.01) but decreased expression of hCAP mRNA (10-fold and 30-fold, both p &lt; 0.001).	Vitamin D	154-163	dermcidin	Homo sapiens	268-272
19299728-9	2009	These data suggest that a key role of vitamin D in innate immunity is to maintain localized production of antibacterial hCAP following TLR activation of monocytes.	Vitamin D	38-47	dermcidin	Homo sapiens	120-124
19429446-8	2009	These data suggest that VDR deficiency in mice is associated with decreased balance function, and may be relevant to poorer balance/posture control in humans with low levels of vitamin D.	Vitamin D	177-186	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
21877200-10	2012	CONCLUSIONS: Circulating soluble FASN relates to both adipose tissue and bone biomarkers in prepubertal children, with associations that are dependent on Vit D concentrations.	Vitamin D	154-159	fatty acid synthase	Homo sapiens	33-37
19122196-1	2009	The nuclear receptor vitamin D receptor (VDR) is known to associate with three vitamin D response element (VDREs)-containing regions within the CDKN1A (p21) gene region.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	41-44
19371802-7	2009	New pathways of vitamin D regulation also have been discovered, involving fibroblast growth factor-23 and klotho.	Vitamin D	16-25	fibroblast growth factor 23	Homo sapiens	74-112
19063940-2	2009	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis.	Vitamin D	91-100	fibroblast growth factor 23	Mus musculus	0-27
22720752-1	2012	BACKGROUND: The vitamin D3 receptor (VDR) is responsible for mediating the pleiotropic and, in part, cell-type-specific effects of 1,25-dihydroxyvitamin D3 (calcitriol) on the cardiovascular and the muscle system, on the bone development and maintenance, mineral homeostasis, cell proliferation, cell differentiation, vitamin D metabolism, and immune response modulation.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	37-40
19063940-2	2009	Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis.	Vitamin D	91-100	fibroblast growth factor 23	Mus musculus	29-34
19116321-2	2009	Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide polymorphisms (SNPs) on 25(OH)D concentrations is unclear.	Vitamin D	56-65	GC vitamin D binding protein	Homo sapiens	0-25
21286859-8	2012	The low vitamin D concentration in H. pylori gastritis patients might act as predisposing factor for a more severe Th1-type aggression to the stomach epithelium.	Vitamin D	8-17	negative elongation factor complex member C/D	Homo sapiens	115-118
19363780-2	2009	In this review article we summarize the basic concepts regarding vitamin D metabolism, transport, and genomic activity through the vitamin D receptor, facilitating activation or suppression of target genes.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	131-149
22421513-0	2012	Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease.	Vitamin D	17-26	fibroblast growth factor 23	Homo sapiens	8-13
22275473-5	2012	RESULTS AND DISCUSSION: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	48-51
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	114-123	nuclear receptor subfamily 1, group I, member 2	Mus musculus	77-80
22065093-1	2012	OBJECTIVES: To identify relationships between vitamin D serum levels and the presence of autoantibodies directed against vitamin D and levels of interleukin(IL)-17 and IL-23 in patients with systemic lupus erythematosus (SLE).	Vitamin D	46-55	interleukin 17A	Homo sapiens	145-163
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	114-123	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	167-174
18981260-7	2009	Thus, our present study defines the novel molecular mechanism by which PXR and CAR mediate drug interactions with vitamin D(3) to regulate the CYP24A1 gene.	Vitamin D	114-123	nuclear receptor subfamily 1, group I, member 2	Mus musculus	71-74
18981260-7	2009	Thus, our present study defines the novel molecular mechanism by which PXR and CAR mediate drug interactions with vitamin D(3) to regulate the CYP24A1 gene.	Vitamin D	114-123	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	143-150
18726998-9	2009	This suggests that decreased recruitment of VDR to vitamin D response elements also contributes to the blunted transcriptional responsiveness to 1,25(OH)(2)D(3) in proliferating Caco-2 cells.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	44-47
22285938-1	2012	The vitamin D(3) catabolizing enzyme, CYP24, is frequently over-expressed in tumors, where it may support proliferation by eliminating the growth suppressive effects of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)).	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	38-43
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	80-89	thioredoxin 1	Mus musculus	18-29
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	80-89	thioredoxin 1	Mus musculus	122-133
18854401-1	2009	CONTEXT: Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate.	Vitamin D	93-102	fibroblast growth factor 23	Homo sapiens	108-135
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	215-224	thioredoxin 1	Mus musculus	18-29
18854401-1	2009	CONTEXT: Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate.	Vitamin D	93-102	fibroblast growth factor 23	Homo sapiens	137-142
21929372-1	2012	SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D.	Vitamin D	215-224	thioredoxin 1	Mus musculus	122-133
18854401-8	2009	EVIDENCE SYNTHESIS: Serum FGF23 concentrations in the patient with Jansen"s syndrome were found to be markedly and persistently elevated, compared with values in healthy, age-matched controls, despite hypophosphatemia and normal 1,25(OH)(2) vitamin D levels.	Vitamin D	241-250	fibroblast growth factor 23	Homo sapiens	26-31
19027855-6	2009	RNA expression of VDR and 24 OHase was upregulated along with vitamin D analogue treatment.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	18-21
21898178-1	2012	Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate and vitamin D metabolism.	Vitamin D	74-83	fibroblast growth factor 23	Homo sapiens	0-27
21898178-1	2012	Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate and vitamin D metabolism.	Vitamin D	74-83	fibroblast growth factor 23	Homo sapiens	29-34
19027855-6	2009	RNA expression of VDR and 24 OHase was upregulated along with vitamin D analogue treatment.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	26-34
19027855-8	2009	In conclusion, SZ95 sebocytes express VDR and the enzymatic machinery to synthesize and metabolize biologically active vitamin D analogues.	Vitamin D	119-128	vitamin D receptor	Homo sapiens	38-41
21523392-8	2012	Vitamin D insufficiency significantly increased the rate of falls in men (IRR = 1.94, 95% CI = 1.19-3.15, p = 0.008) but not in women.	Vitamin D	0-9	insulin receptor related receptor	Homo sapiens	74-77
19121771-2	2009	FGF23 is a 251-amino acid secreted protein produced by osteoblasts and osteocytes in bone following the stimulation by phosphate and vitamin D or the inhibition by dentin matrix protein 1.	Vitamin D	133-142	fibroblast growth factor 23	Homo sapiens	0-5
19287183-1	2009	It has recently been proposed that statins act as vitamin D analogs in binding the ubiquitously expressed vitamin D receptor, accounting for the perceived pleiotropic effects of statins (a reduction in cancer risk, prevention of organ transplant rejection and autoimmune disease).	Vitamin D	50-59	vitamin D receptor	Homo sapiens	106-124
19287183-3	2009	Vitamin D suppresses parathyroid hormone (PTH) secretion in part through its action on the vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	91-109
22008880-0	2012	Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden.	Vitamin D	10-19	MROS	Homo sapiens	75-79
24459525-14	2008	FGF23:klotho complex bound to FGF receptor inhibits 1alpha-hydroxylase of vitamin D, and contributes to calcium reabsorption and phosphate excretion in the kidney.	Vitamin D	74-83	fibroblast growth factor 23	Homo sapiens	0-5
22207345-9	2012	Together, our findings identify a novel vitamin D-mediated chemopreventive mechanism involving a positive feedback loop between the DNA repair proteins ATM and VDR.	Vitamin D	40-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	160-163
22193171-1	2012	The anticarcinogenic potential of vitamin D might be mediated by not only calcium metabolism but also other mechanisms initiated by vitamin D receptor (VDR).	Vitamin D	34-43	vitamin D receptor	Homo sapiens	132-150
24459525-14	2008	FGF23:klotho complex bound to FGF receptor inhibits 1alpha-hydroxylase of vitamin D, and contributes to calcium reabsorption and phosphate excretion in the kidney.	Vitamin D	74-83	klotho	Homo sapiens	6-12
22193171-1	2012	The anticarcinogenic potential of vitamin D might be mediated by not only calcium metabolism but also other mechanisms initiated by vitamin D receptor (VDR).	Vitamin D	34-43	vitamin D receptor	Homo sapiens	152-155
18827005-2	2008	OBJECTIVE: Genetic variants in the promoter region of the vitamin D receptor (VDR) gene may explain the response to treatment because this receptor mediates vitamin D action.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	78-81
22144504-0	2012	Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.	Vitamin D	69-78	GC vitamin D binding protein	Homo sapiens	29-31
22144504-2	2012	This study evaluated associations between polymorphic variation in the Gc-globulin (GC) and calcium-sensing receptor (CASR) and odds for metachronous colorectal neoplasia and vitamin D metabolite concentrations.	Vitamin D	175-184	GC vitamin D binding protein	Homo sapiens	71-82
22144504-2	2012	This study evaluated associations between polymorphic variation in the Gc-globulin (GC) and calcium-sensing receptor (CASR) and odds for metachronous colorectal neoplasia and vitamin D metabolite concentrations.	Vitamin D	175-184	GC vitamin D binding protein	Homo sapiens	84-86
18561994-1	2008	Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease.	Vitamin D	4-13	negative elongation factor complex member C/D	Homo sapiens	61-64
22493603-3	2012	The etiology of the hypercalcemia is presumed to be a neoplastic expression of fibroblast growth factor-23, which was found to be inappropriately high-to-normal when other factors such as parathyroid hormone, calcitonin and vitamin D were appropriately low or low-to-normal.	Vitamin D	224-233	fibroblast growth factor 23	Homo sapiens	79-106
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	156-161
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	solute carrier family 22 member 3	Homo sapiens	228-235
21956231-7	2012	Biostatistical evaluation of microarray data by Ingenuity Pathways Analysis (IPA) revealed a relevant modulation of genes involved in vitamin D metabolism (CYP24), immune functions (CD14), neurotransmitter transporters (SLC1A1, SLC22A3), and coagulation [thrombomodulin (THBD), tissue plasminogen activator (PLAT), endothelial protein C receptor (PROCR), thrombin receptor (F2R)].	Vitamin D	134-143	chromosome 20 open reading frame 181	Homo sapiens	278-306
22121948-8	2012	The relationship between FGF23 and serum vitamin D needs further evaluation.	Vitamin D	41-50	fibroblast growth factor 23	Homo sapiens	25-30
22396166-3	2012	Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.	Vitamin D	61-70	fibroblast growth factor 23	Homo sapiens	0-27
22396166-3	2012	Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.	Vitamin D	61-70	fibroblast growth factor 23	Homo sapiens	29-34
22396168-2	2012	Particularly, appropriate actions of FGF23 are essential for maintaining physiological phosphate and vitamin D metabolism.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	37-42
22213316-1	2012	The transcription factor vitamin D receptor (VDR) is the nuclear sensor for the biologically most active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	45-48
22213318-1	2012	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in prostate cancer cells.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	95-113
22213318-1	2012	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in prostate cancer cells.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	115-118
22213318-2	2012	Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	245-253
22213318-2	2012	Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	258-265
22213318-8	2012	Thus, in addition to 1alpha,25(OH)(2)D analogs, the presence of CYP2R1, CYP27B1 and CYP24A1 in the prostate suggests that the analogs of vitamin D and 25(OH)D, especially those that are resistant to CYP24A1 degradation, can be developed and used for the prevention and treatment of prostate cancer.	Vitamin D	137-146	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	84-91
22213321-1	2012	The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	55-73
22213321-1	2012	The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	75-78
22213323-1	2012	BACKGROUND: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	12-30
22213323-1	2012	BACKGROUND: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	32-35
22213323-7	2012	Comparison of the frequencies of the VDR genotypes in sunlight-exposed vs. not sunlight-exposed skin areas revealed BB 30.1% vs. 7.1% respectively in BCCs and BB 28.1% vs. 0.0% respectively in SCCs, indicating that vitamin D signalling may be of importance for photocarcinogenesis of the skin.	Vitamin D	215-224	vitamin D receptor	Homo sapiens	37-40
22242854-3	2012	The crystal structure of the VDR and detailed knowledge on its molecular interactions with the ligand provide significant insight into the mechanisms of vitamin D signaling.	Vitamin D	153-162	vitamin D receptor	Homo sapiens	29-32
22738935-3	2012	Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	98-116
22738935-3	2012	Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	118-121
21755299-1	2012	BACKGROUND: Vitamin D, which exerts its effect through vitamin D receptor (VDR), and LL-37, a vitamin D-dependent antimicrobial peptide, are involved in many infectious diseases.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	55-73
21755299-1	2012	BACKGROUND: Vitamin D, which exerts its effect through vitamin D receptor (VDR), and LL-37, a vitamin D-dependent antimicrobial peptide, are involved in many infectious diseases.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	75-78
21755299-1	2012	BACKGROUND: Vitamin D, which exerts its effect through vitamin D receptor (VDR), and LL-37, a vitamin D-dependent antimicrobial peptide, are involved in many infectious diseases.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	75-78
22988423-6	2012	The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1 alpha-hydroxylase gene.	Vitamin D	22-31	GC vitamin D binding protein	Homo sapiens	144-169
22988423-6	2012	The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1 alpha-hydroxylase gene.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	171-189
22615584-4	2012	We recently reported that complete ablation of PTH from Fgf23(-/-) mice ameliorated the phenotype in Fgf23(-/-)/PTH(-/-) mice by suppressing serum vitamin D and calcium levels.	Vitamin D	147-156	fibroblast growth factor 23	Mus musculus	56-61
22615584-4	2012	We recently reported that complete ablation of PTH from Fgf23(-/-) mice ameliorated the phenotype in Fgf23(-/-)/PTH(-/-) mice by suppressing serum vitamin D and calcium levels.	Vitamin D	147-156	fibroblast growth factor 23	Mus musculus	101-106
23119081-4	2012	Previous studies have also shown that CYP24A1 (an enzyme implicated in vitamin D metabolism), might play an important role in furthering the progression of kidney lesions during diabetic nephropathy.	Vitamin D	71-80	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	38-45
23119081-10	2012	We concluded that diabetes induces an increase in CYP24A1 expression, destabilizing vitamin D metabolism in the renal proximal tubules, leading to cellular instability and apoptosis, and thereby accelerating tubular injury progression during diabetic nephropathy.	Vitamin D	84-93	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	50-57
23166493-2	2012	We report here that TLR8 activation in human macrophages induces the expression of the human cathelicidin microbial peptide (CAMP), the vitamin D receptor (VDR) and cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1), which 1alpha-hydroxylates the inactive form of vitamin D, 25-hydroxycholecalciferol, into its biologically active metabolite.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	156-159
22536762-5	2012	The hydrophobic nature of the analyte, the high concentration and affinity of vitamin D binding protein (VDBP) in serum and the cross-reactivity requirements due to the broad spectrum of metabolites of vitamin D are most demanding for assay development.	Vitamin D	78-87	GC vitamin D binding protein	Homo sapiens	105-109
22536764-3	2012	The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	85-103
22536764-3	2012	The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	105-108
22536764-7	2012	Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	140-143
22536768-2	2012	Expression of the vitamin D receptor (VDR) and enzymes for vitamin D metabolism have been identified in the vasculature as well as in the heart.	Vitamin D	18-27	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	38-41
22536770-2	2012	The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
22536770-7	2012	Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	8-11
22066785-2	2011	This carborane-based VDR ligand exhibited moderate vitamin D activity, comparable to that of the natural hormone, despite its simple and flexible structure.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	21-24
21930286-4	2011	We observed that adult offspring born to vitamin D deficient mothers, when compared to control offspring, developed a striking milder and delayed experimental autoimmune encephalomyelitis (EAE) and permanently overexpressed the vitamin D receptor.	Vitamin D	41-50	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	228-246
21693169-1	2011	Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	92-110
21693169-1	2011	Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
21801808-5	2011	Conversely, any situation that impairs the efficiency of the 1,25-(OH)(2)D(3)/VDR signaling system at the level of the gut mucosa, e.g. vitamin D insufficiency, may increase risk for the development of IBD and colorectal cancer.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	78-81
18561994-6	2008	The seemingly paradoxical effects of 1,25(OH)(2)D(3) and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system.	Vitamin D	57-66	negative elongation factor complex member C/D	Homo sapiens	70-73
18561994-6	2008	The seemingly paradoxical effects of 1,25(OH)(2)D(3) and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system.	Vitamin D	149-158	negative elongation factor complex member C/D	Homo sapiens	70-73
18829467-1	2008	FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion.	Vitamin D	170-179	fibroblast growth factor 23	Homo sapiens	44-49
18981132-0	2008	IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.	Vitamin D	61-70	interleukin 15	Homo sapiens	0-5
18981132-6	2008	Therefore, IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.	Vitamin D	72-81	interleukin 15	Homo sapiens	11-16
18709640-0	2008	Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	189-192
18709640-0	2008	Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	189-192
18709640-2	2008	Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	112-130
18709640-2	2008	Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	132-135
18709640-7	2008	The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	134-137
19014363-5	2008	In fact, it is known that VDR is a transcription factor, and that in vitamin-D-depleted animals, VDR is largely localized in the cell nucleus.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	97-100
18767073-2	2008	The vitamin D metabolite 1alpha,25(OH)2D3 mediates growth inhibitory signaling via activation of the vitamin D receptor (VDR), a ligand dependent transcription factor.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	101-119
18767073-2	2008	The vitamin D metabolite 1alpha,25(OH)2D3 mediates growth inhibitory signaling via activation of the vitamin D receptor (VDR), a ligand dependent transcription factor.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	121-124
18767073-4	2008	Human mammary epithelial (HME) cells express VDR and CYP27b1 and undergo growth inhibition when exposed to physiological concentrations of 25(OH)D3, suggesting that autocrine or paracrine vitamin D signaling contributes to maintenance of differentiation and quiescence in the mammary epithelium.	Vitamin D	188-197	vitamin D receptor	Homo sapiens	45-48
18832725-5	2008	Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	219-240
18562594-6	2008	Genetically engineered mice with upregulated vitamin D signaling pathways have also shed light on the molecular intermediaries, including fibroblast growth factor-23 and transcriptional intermediary factor 1-alpha.	Vitamin D	45-54	fibroblast growth factor 23	Mus musculus	138-213
21914460-0	2011	Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	65-92
18474231-5	2008	Vitamin D-resistant syndromes are caused by hereditary defects in metabolic activation of the hormone or by mutations in the vitamin D receptor, which binds the hormone with high affinity and regulates the expression of genes through zinc finger mediated DNA binding and protein-protein interaction.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	125-143
21914460-5	2011	Dietary Pi intake and serum Pi concentration also are important determinants of the circulating concentration of FGF-23, itself a potent regulator of Pi and vitamin D metabolism.	Vitamin D	157-166	fibroblast growth factor 23	Homo sapiens	113-119
18474231-12	2008	Vitamin D analogs which induce unusual structural conformations on the vitamin D receptor may have a variety of therapeutic indications.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	71-89
22018918-10	2011	The in vitro tests indicated that, compared to the analogue 7, unsubstituted at C-13, the synthesized vitamin D analogue 10 showed markedly improved VDR binding ability, significantly enhanced HL-60 differentiation activity as well as increased transcriptional potency.	Vitamin D	102-111	vitamin D receptor	Homo sapiens	149-152
18485278-1	2008	The regulation of vitamin D receptor (VDR), a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	38-41
18624678-5	2008	By using the PXR knockout and humanized mouse models, PXR was found to influence drug-drug interactions, hepatic steatosis, and the homeostasis of vitamin D, bile acids, and steroid hormones.	Vitamin D	147-156	nuclear receptor subfamily 1, group I, member 2	Mus musculus	54-57
22034506-1	2011	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	27-54
22034506-1	2011	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	56-61
18567755-1	2008	The major circulating form of vitamin D, 25-hydroxycholecalciferol (25D3), circulates bound to vitamin D-binding protein (DBP).	Vitamin D	30-39	GC vitamin D binding protein	Homo sapiens	95-120
21764620-12	2011	CONCLUSION: The rate of vitamin D deficiency was high in our T2D patients, and was associated with the VDR gene FokI and ApaI polymorphisms and cardiovascular risk profile.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	103-106
21764620-13	2011	Measurements of vitamin D may help to detect T2D patients with cardiovascular risk, and VDR polymorphisms might explain why vitamin D deficiency is so frequently seen in some T2D patients.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	88-91
18038108-3	2008	INTRODUCTION: Vitamin D-binding protein (DBP) plays a critical role in the transport and metabolism of metabolites of vitamin D, including the key calciotropic hormone 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Vitamin D	118-127	GC vitamin D binding protein	Homo sapiens	14-39
18362166-0	2008	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	61-80
22017388-4	2011	Vitamin D receptor activators, such as paricalcitol and doxercalciferol, with fewer calcemic and phosphatemic effects, have also been introduced to control parathormone production and the interest in native vitamin D supplementation has grown.	Vitamin D	207-216	vitamin D receptor	Homo sapiens	0-18
21890490-2	2011	Here, we show that human JMJD3 expression is induced by the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and that JMJD3 modulates the gene regulatory action of this hormone.	Vitamin D	67-76	lysine demethylase 6B	Homo sapiens	147-152
18362166-0	2008	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	Vitamin D	51-60	retinoid X receptor alpha	Homo sapiens	61-80
18518851-4	2008	Furthermore, varying responsiveness to vitamin D and estrogen-based treatments may reflect allele variation in their signaling pathway genes (e.g., VDR or ERalpha).	Vitamin D	39-48	vitamin D receptor	Homo sapiens	148-151
18424254-1	2008	Vitamin D requires two metabolic conversions, 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney, before its hormonal form, 1,25-dihydroxyvitamin D [1,25-(OH)2D], can bind to the vitamin D receptor (VDR) to modulate gene transcription and regulate mineral ion homeostasis.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	197-215
18424254-1	2008	Vitamin D requires two metabolic conversions, 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney, before its hormonal form, 1,25-dihydroxyvitamin D [1,25-(OH)2D], can bind to the vitamin D receptor (VDR) to modulate gene transcription and regulate mineral ion homeostasis.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	217-220
18424254-4	2008	The classical view is that vitamin D exerts its effects on bone indirectly via control of calcium and phosphate homeostasis, despite expression of cyp27b1, the 25-hydroxyvitamin D-1alpha-hydroxylase, and the VDR in osteoblasts and chondrocytes.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	208-211
18004750-4	2008	Whether there are two vitamin D binding-sites in each beta-LG molecule has been a subject of controversy.	Vitamin D	22-31	beta-lactoglobulin	Bos taurus	54-61
18004750-12	2008	This finding provides a new insight into the interaction between vitamin D(3) and beta-LG, in which the exosite may provide another route for the transport of vitamin D(3) in vitamin D(3) fortified dairy products.	Vitamin D	65-74	beta-lactoglobulin	Bos taurus	82-89
18004750-12	2008	This finding provides a new insight into the interaction between vitamin D(3) and beta-LG, in which the exosite may provide another route for the transport of vitamin D(3) in vitamin D(3) fortified dairy products.	Vitamin D	159-168	beta-lactoglobulin	Bos taurus	82-89
18004750-12	2008	This finding provides a new insight into the interaction between vitamin D(3) and beta-LG, in which the exosite may provide another route for the transport of vitamin D(3) in vitamin D(3) fortified dairy products.	Vitamin D	159-168	beta-lactoglobulin	Bos taurus	82-89
18194670-1	2008	BACKGROUND: Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation.	Vitamin D	27-36	GC vitamin D binding protein	Homo sapiens	12-23
18194670-17	2008	Under consideration of the available literature, these findings propose a participation of gc-globulin in hepatic vitamin D metabolism as well as in hepatic stellate cell stability and apoptosis as important mechanisms of liver regeneration.	Vitamin D	114-123	GC vitamin D binding protein	Homo sapiens	91-102
18212051-10	2008	The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene.	Vitamin D	41-50	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	60-63
18212051-10	2008	The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene.	Vitamin D	41-50	nuclear receptor coactivator 3	Mus musculus	83-88
18212051-10	2008	The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene.	Vitamin D	41-50	nuclear receptor coactivator 3	Mus musculus	133-138
18212051-10	2008	The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene.	Vitamin D	41-50	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	142-145
18083724-15	2008	Calcium and vitamin D prescription was significantly increased in the intervention group over the control group (IRR = 1.64 [1.23, 2.18] P&lt;0.01).	Vitamin D	12-21	insulin receptor related receptor	Homo sapiens	113-116
18497440-2	2008	Vitamin D is a prohormone which is converted into its active hormonal form 1, 25 (OH)D2 D, 1, 25 (OH)D2 D activates its cellular receptor (VDR) which activate target genes to engender its biological actions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	139-142
18327422-6	2008	RESULTS: TACO gene down-regulation observed with vitamin D(3)/RA treatment occurred through modulation of this gene via the VDR/RXR response sequence present in the promoter region of TACO gene.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	124-127
18327422-6	2008	RESULTS: TACO gene down-regulation observed with vitamin D(3)/RA treatment occurred through modulation of this gene via the VDR/RXR response sequence present in the promoter region of TACO gene.	Vitamin D	49-58	retinoid X receptor alpha	Homo sapiens	128-131
18259074-2	2008	Hormonal forms of vitamin D regulate transcription by binding with the high-affinity vitamin D receptor (VDR).	Vitamin D	18-27	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	85-103
18259074-2	2008	Hormonal forms of vitamin D regulate transcription by binding with the high-affinity vitamin D receptor (VDR).	Vitamin D	18-27	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	105-108
18259074-3	2008	OBJECTIVE: To assess the effects of impaired vitamin D action in VDR knockout (KO) mice on hearing, cochlear morphology, and cochlear gene expression.	Vitamin D	45-54	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	65-68
17970811-0	2008	A novel mutation in the VDR gene in hereditary vitamin D-resistant rickets.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	24-27
21812032-0	2011	Hereditary vitamin D-resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	87-105
21812032-1	2011	Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disease caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	112-130
21812032-1	2011	Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disease caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
21786227-6	2011	The association between altered levels of FGF23 and bone disease could be mainly due to the dysregulation of phosphate-handling and vitamin D metabolism, more than to a direct antiosteoblastic activity of FGF23.	Vitamin D	132-141	fibroblast growth factor 23	Homo sapiens	42-47
21786227-10	2011	This paradox highlights the need for future prospective randomized trials to evaluate the correlation between vitamin D therapy and FGF23 levels in dialysis patients.	Vitamin D	110-119	fibroblast growth factor 23	Homo sapiens	132-137
21878656-4	2011	Here, we show that the application of the physiologically active form of vitamin D(3), calcitriol, inhibits proliferation and growth of BCC of Ptch mutant mice in vitro and in vivo.	Vitamin D	73-82	patched 1	Mus musculus	143-147
21982773-4	2011	Herein we characterize vitamin D receptor-mediated regulation of klotho mRNA expression, including the identification of vitamin D responsive elements (VDREs) in the vicinity of both the mouse and human klotho genes.	Vitamin D	23-32	klotho	Mus musculus	65-71
21982773-4	2011	Herein we characterize vitamin D receptor-mediated regulation of klotho mRNA expression, including the identification of vitamin D responsive elements (VDREs) in the vicinity of both the mouse and human klotho genes.	Vitamin D	23-32	klotho	Homo sapiens	203-209
21982773-5	2011	In keeping with other recent studies of vitamin D-regulated genes, multiple VDREs control klotho expression, with the most active elements located at some distance (-31 to -46 kb) from the klotho transcriptional start site.	Vitamin D	40-49	klotho	Homo sapiens	90-96
21982773-5	2011	In keeping with other recent studies of vitamin D-regulated genes, multiple VDREs control klotho expression, with the most active elements located at some distance (-31 to -46 kb) from the klotho transcriptional start site.	Vitamin D	40-49	klotho	Homo sapiens	189-195
21853245-3	2011	RESULTS: Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (-2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (-5.79 for heterozygotes versus wild type, p = &lt;0.0001).	Vitamin D	39-48	GC vitamin D binding protein	Homo sapiens	213-238
22155603-9	2011	Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort.	Vitamin D	160-169	vitamin D receptor	Homo sapiens	208-226
22155603-9	2011	Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort.	Vitamin D	160-169	vitamin D receptor	Homo sapiens	228-231
22155603-11	2011	Single point variants in CYP24A1 (the gene encoding the catabolising enzyme of the vitamin D pathway) were demonstrated to influence AMD risk after controlling for smoking history, sex and age in all populations, both separately and, more importantly, in a meta-analysis.	Vitamin D	83-92	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	25-32
22194708-2	2011	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	61-79
22194708-2	2011	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	81-84
22194708-2	2011	The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	131-134
21812026-0	2011	FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone.	Vitamin D	22-31	fibroblast growth factor 23	Mus musculus	0-3
21812026-1	2011	The functional interaction between fibroblast growth factor 23 (FGF-23) and Klotho in the control of vitamin D and phosphate homeostasis is manifested by the largely overlapping phenotypes of Fgf23- and Klotho-deficient mouse models.	Vitamin D	101-110	fibroblast growth factor 23	Mus musculus	35-62
21812026-1	2011	The functional interaction between fibroblast growth factor 23 (FGF-23) and Klotho in the control of vitamin D and phosphate homeostasis is manifested by the largely overlapping phenotypes of Fgf23- and Klotho-deficient mouse models.	Vitamin D	101-110	fibroblast growth factor 23	Mus musculus	64-70
21812026-1	2011	The functional interaction between fibroblast growth factor 23 (FGF-23) and Klotho in the control of vitamin D and phosphate homeostasis is manifested by the largely overlapping phenotypes of Fgf23- and Klotho-deficient mouse models.	Vitamin D	101-110	klotho	Mus musculus	76-82
21812026-6	2011	Further, we show that FGFR inhibition blocks Fgf23 transcription in bone and that this is dominant over vitamin D-induced Fgf23 expression, ultimately impinging on systemic FGF-23 protein levels.	Vitamin D	104-113	fibroblast growth factor 23	Mus musculus	122-127
21812026-6	2011	Further, we show that FGFR inhibition blocks Fgf23 transcription in bone and that this is dominant over vitamin D-induced Fgf23 expression, ultimately impinging on systemic FGF-23 protein levels.	Vitamin D	104-113	fibroblast growth factor 23	Mus musculus	173-179
21812026-8	2011	Thus, in line with Fgf23- and Klotho-deficient mouse models, our study illustrates the essential function of FGFRs in the regulation of vitamin D and phosphate levels.	Vitamin D	136-145	klotho	Mus musculus	30-36
21812026-9	2011	Further, we reveal FGFR signaling as a novel in vivo control mechanism for Fgf23 expression in bone, suggesting a dual function of FGFRs in the FGF-23/Klotho pathway leading to vitamin D and phosphate homeostasis.	Vitamin D	177-186	fibroblast growth factor 23	Mus musculus	75-80
21812026-9	2011	Further, we reveal FGFR signaling as a novel in vivo control mechanism for Fgf23 expression in bone, suggesting a dual function of FGFRs in the FGF-23/Klotho pathway leading to vitamin D and phosphate homeostasis.	Vitamin D	177-186	fibroblast growth factor 23	Mus musculus	144-150
21812026-9	2011	Further, we reveal FGFR signaling as a novel in vivo control mechanism for Fgf23 expression in bone, suggesting a dual function of FGFRs in the FGF-23/Klotho pathway leading to vitamin D and phosphate homeostasis.	Vitamin D	177-186	klotho	Mus musculus	151-157
18419802-1	2008	INTRODUCTION: Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	14-32
18419802-1	2008	INTRODUCTION: Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	34-37
18166826-1	2008	OBJECTIVE: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	11-38
18166826-1	2008	OBJECTIVE: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	40-45
18368510-4	2008	We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	36-63
18368510-4	2008	We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	65-71
17646263-0	2007	Correlation among hyperphosphatemia, type II sodium phosphate transporter activity, and vitamin D metabolism in Fgf-23 null mice.	Vitamin D	88-97	fibroblast growth factor 23	Mus musculus	112-118
17646263-5	2007	Further studies using our Fgf-23(-/-) mice have identified an inverse correlation between Fgf-23, and vitamin D or NaPi2a; genomic elimination of either vitamin D or NaPi2a activities from Fgf-23(-/-) mice could reverse severe hyperphosphatemia to hypophosphatemia, and consequently could alter skeletal mineralization, suggesting that regulation of phosphate homeostasis in Fgf-23(-/-) mice is vitamin D- and NaPi2a-mediated process.	Vitamin D	102-111	fibroblast growth factor 23	Mus musculus	90-96
17646263-5	2007	Further studies using our Fgf-23(-/-) mice have identified an inverse correlation between Fgf-23, and vitamin D or NaPi2a; genomic elimination of either vitamin D or NaPi2a activities from Fgf-23(-/-) mice could reverse severe hyperphosphatemia to hypophosphatemia, and consequently could alter skeletal mineralization, suggesting that regulation of phosphate homeostasis in Fgf-23(-/-) mice is vitamin D- and NaPi2a-mediated process.	Vitamin D	102-111	fibroblast growth factor 23	Mus musculus	90-96
17646263-5	2007	Further studies using our Fgf-23(-/-) mice have identified an inverse correlation between Fgf-23, and vitamin D or NaPi2a; genomic elimination of either vitamin D or NaPi2a activities from Fgf-23(-/-) mice could reverse severe hyperphosphatemia to hypophosphatemia, and consequently could alter skeletal mineralization, suggesting that regulation of phosphate homeostasis in Fgf-23(-/-) mice is vitamin D- and NaPi2a-mediated process.	Vitamin D	102-111	fibroblast growth factor 23	Mus musculus	90-96
17967727-1	2007	The discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact that activated dendritic cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	41-44
21832078-6	2011	Finally and paradoxically, ER stress instead suppresses the 1,25(OH)(2) vitamin D(3)-induced activation of VDR, but blockade of VDR activity does not alter ER stress-induced CAMP up-regulation.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	107-110
17906399-4	2007	Recently, much attention is paid to the roles of FGF23 and Klotho, both of which are molecules critical in phosphate homeostasis, in vitamin D metabolism.	Vitamin D	133-142	fibroblast growth factor 23	Homo sapiens	49-54
21715350-2	2011	The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1alpha-hydroxylase, the enzyme required to convert 25(OH)D(3) to 1,25(OH)(2)D(3), and measured vitamin D metabolite concentrations in aqueous and vitreous humor.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	80-83
21529994-1	2011	The vitamin D metabolite, 1,25-(OH)2D3, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	50-68
21529994-1	2011	The vitamin D metabolite, 1,25-(OH)2D3, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	70-73
17906399-4	2007	Recently, much attention is paid to the roles of FGF23 and Klotho, both of which are molecules critical in phosphate homeostasis, in vitamin D metabolism.	Vitamin D	133-142	klotho	Homo sapiens	59-65
17906409-3	2007	VDR deficient mice (conventional-VDRKO mice) appear the typical phenotype of vitamin D dependent type II rickets.	Vitamin D	77-86	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
17628009-10	2007	These data provide proof of principle that UV exposure modulates tumor growth via elevation of vitamin D signaling and that therapeutic approaches designed to target the vitamin D pathway will be effective only if tumor cells express functional VDR.	Vitamin D	170-179	vitamin D receptor	Homo sapiens	245-248
25018911-6	2011	Therefore, compounds that selectively activate vitamin D receptors (VDR activators), potentially reducing Ca-P toxicity and distinctly affecting pathogenic mechanisms of VC, might enhance CV and renal protection, increase the vitamin D therapeutic window, and thus provide a significant clinical benefit.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	68-71
25018912-3	2011	The link between vitamin D deficiency and death is a defective activation of the vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D (calcitriol, the vitamin D hormone) to induce/repress genes that maintain mineral homeostasis and skeletal integrity, and prevent secondary hyperparathyroidism, hypertension, immune disorders, and renal and cardiovascular (CV) damage.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	81-99
25018912-3	2011	The link between vitamin D deficiency and death is a defective activation of the vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D (calcitriol, the vitamin D hormone) to induce/repress genes that maintain mineral homeostasis and skeletal integrity, and prevent secondary hyperparathyroidism, hypertension, immune disorders, and renal and cardiovascular (CV) damage.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	101-104
17723171-2	2007	The vitamin D receptor (VDR) is expressed in mammary epithelial cells, suggesting that vitamin D may directly influence sensitivity of the gland to transformation.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
21746882-2	2011	The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], has a direct repressive effect on the expression of IL-17A in both human and mouse T cells.	Vitamin D	19-28	interleukin 17A	Homo sapiens	128-134
21924212-3	2011	In this sense, fibroblast growth factor 23 (FGF-23) has been identified as a new hormone involved in phosphate regulation through feedback mechanisms involving parathyroid hormone and vitamin D.	Vitamin D	184-193	fibroblast growth factor 23	Homo sapiens	15-42
17449905-10	2007	Remarkably, in vivo treatment with the vitamin D analogue EB1089 induced DKK-1 protein expression in SW480-ADH cells xenografted in immunodeficient mice, and a correlation was observed in the expression of VDR and DKK-1 RNA in a series of 32 human colorectal tumours.	Vitamin D	39-48	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	206-209
21924212-3	2011	In this sense, fibroblast growth factor 23 (FGF-23) has been identified as a new hormone involved in phosphate regulation through feedback mechanisms involving parathyroid hormone and vitamin D.	Vitamin D	184-193	fibroblast growth factor 23	Homo sapiens	44-50
17855664-10	2007	Our data suggest that the integrity of the vitamin D/VDR-mediated signaling pathway is crucial in predicting vitamin D responsiveness and thus provide a rational design to improve vitamin D-based treatment efficacy based on molecular profiles of patients.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	53-56
21697097-0	2011	Bioengineering anabolic vitamin D-25-hydroxylase activity into the human vitamin D catabolic enzyme, cytochrome P450 CYP24A1, by a V391L mutation.	Vitamin D	24-33	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
17855664-10	2007	Our data suggest that the integrity of the vitamin D/VDR-mediated signaling pathway is crucial in predicting vitamin D responsiveness and thus provide a rational design to improve vitamin D-based treatment efficacy based on molecular profiles of patients.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	53-56
17855664-10	2007	Our data suggest that the integrity of the vitamin D/VDR-mediated signaling pathway is crucial in predicting vitamin D responsiveness and thus provide a rational design to improve vitamin D-based treatment efficacy based on molecular profiles of patients.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	53-56
17681143-1	2007	klotho was first described as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, acting as a coreceptor for FGF23.	Vitamin D	99-108	klotho	Homo sapiens	0-6
21332944-6	2011	The RANKL expression induced by 1,25-(OH)(2) vitamin D(3) was not affected by RIS in human MSC-derived osteoblasts.	Vitamin D	45-54	TNF superfamily member 11	Homo sapiens	4-9
21592821-1	2011	Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	91-112
21592821-1	2011	Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	114-117
17681143-1	2007	klotho was first described as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, acting as a coreceptor for FGF23.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	148-153
17565275-3	2007	Physiologically, FGF23 is a counter-regulatory phosphaturic hormone for vitamin D and coordinates systemic phosphate homeostasis with skeletal mineralization.	Vitamin D	72-81	fibroblast growth factor 23	Homo sapiens	17-22
21424181-1	2011	Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disorder caused by inactivating mutations in the vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	120-138
21424181-1	2011	Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disorder caused by inactivating mutations in the vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
17565275-9	2007	SUMMARY: FGF23 discovery has uncovered primary regulatory pathways and new systems biology governing bone mineralization, vitamin D metabolism, parathyroid gland function, and renal phosphate handling.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	9-14
21496980-3	2011	FGF-23 is a bone-derived hormone that suppresses phosphate reabsorption and 1,25 dihydroxyvitamin D(3) (vitamin D) synthesis in the kidney.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	0-6
21496980-4	2011	Klotho also is expressed in the parathyroid gland, where FGF-23 decreases parathyroid hormone expression and secretion, further suppressing vitamin D synthesis in kidney.	Vitamin D	140-149	klotho	Homo sapiens	0-6
17592215-2	2007	The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	65-68
21496980-4	2011	Klotho also is expressed in the parathyroid gland, where FGF-23 decreases parathyroid hormone expression and secretion, further suppressing vitamin D synthesis in kidney.	Vitamin D	140-149	fibroblast growth factor 23	Homo sapiens	57-63
21496980-5	2011	Thus, FGF-23 functions as a phosphaturic hormone and a counter-regulatory hormone for vitamin D, thereby inducing negative phosphate balance.	Vitamin D	86-95	fibroblast growth factor 23	Homo sapiens	6-12
22237768-6	2011	RESULTS: IL-10 levels were significantly lower in patients with vitamin D insufficiency compared with the vitamin D replete group (mean and SE 2.48 +- 0.51 v 6.77 +- 2.49 pg/mL, p &lt; 0.001).	Vitamin D	64-73	interleukin 10	Homo sapiens	9-14
22237768-6	2011	RESULTS: IL-10 levels were significantly lower in patients with vitamin D insufficiency compared with the vitamin D replete group (mean and SE 2.48 +- 0.51 v 6.77 +- 2.49 pg/mL, p &lt; 0.001).	Vitamin D	106-115	interleukin 10	Homo sapiens	9-14
17440943-1	2007	BACKGROUND: The vitamin D receptor (VDR) is required for actions of vitamin D.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
22237768-9	2011	CONCLUSION: Circulating levels of IL-10, but not TNF-alpha, were significantly lower in CD patients with inadequate serum 25(OH)D. This suggests that poor vitamin D status may be linked to reduced anti-inflammatory capacity in this group.	Vitamin D	155-164	interleukin 10	Homo sapiens	34-39
21416506-0	2011	Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship.	Vitamin D	39-48	GC vitamin D binding protein	Homo sapiens	0-25
17383948-0	2007	Re: "The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor" by Michaelsson et al.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	145-163
21416506-2	2011	Vitamin D-binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D.	Vitamin D	119-128	GC vitamin D binding protein	Homo sapiens	0-25
21696575-2	2011	This study was designed to evaluate the possible role of VDR single nucleotide polymorphisms (SNPs) on different aspects of diabetic host response (anthropometric, metabolic, oxidative stress and inflammatory) to daily intake of vitamin D through fortified yogurt drink for 12 weeks.	Vitamin D	229-238	vitamin D receptor	Homo sapiens	57-60
17371163-5	2007	INTRODUCTION: Vitamin D plays an essential role in skeletal metabolism by binding to its nuclear steroid receptor, the vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	119-137
21490240-2	2011	The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23).	Vitamin D	72-81	fibroblast growth factor 23	Homo sapiens	102-129
21490240-2	2011	The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23).	Vitamin D	72-81	fibroblast growth factor 23	Homo sapiens	131-136
17371163-5	2007	INTRODUCTION: Vitamin D plays an essential role in skeletal metabolism by binding to its nuclear steroid receptor, the vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	139-142
21427118-1	2011	BACKGROUND: The vitamin D receptor (VDR) is expressed in human spermatozoa, and VDR-knockout mice and vitamin D (VD) deficiency in rodents results in impaired fertility, low sperm counts and a low number of motile spermatozoa.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
17393546-4	2007	Here, we describe the synthesis and in vitro assessment of a photocaged VDR agonist specific to a mutant NHR that is associated with vitamin D-resistant rickets.	Vitamin D	133-142	vitamin D receptor	Homo sapiens	72-75
21482732-2	2011	Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ.	Vitamin D	143-152	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	47-50
21623580-1	2011	The widely differing functions of vitamin D are based both on a wide diffusion of its specific receptor (VDR) and on the ability of many cells, in addition to renal tubular cells, to synthesize calcitriol for autocrine and paracrine functions.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	105-108
21623580-4	2011	Furthermore, the mechanisms by which the VDR might mediate either the genomic and nongenomic (rapid) vitamin D-mediated effects became much clearer.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	41-44
17130524-7	2007	In addition, nuclear receptor cofactors NCoR1 and SRC1 that could potentially affect VDR action were also low in both MDA-MB231 and S30 cells in comparison with ER-positive, vitamin D-sensitive BT474 cells.	Vitamin D	174-183	vitamin D receptor	Homo sapiens	85-88
21623580-5	2011	However, new evidence accumulated suggests that some additional receptor(s), responsive to vitamin D and different from the VDR, could play a role in the rapid response to vitamin D, probably interfering also with the genomic pathway.	Vitamin D	172-181	vitamin D receptor	Homo sapiens	124-127
20655720-2	2011	The study evaluates the effect of vitamin D(3) in preventing the altered function of cholinergic, insulin receptors and GLUT3 in the cerebral cortex of diabetic rats.	Vitamin D	34-43	solute carrier family 2 member 3	Rattus norvegicus	120-125
17130524-8	2007	These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	90-93
17130524-8	2007	These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	90-93
17130524-8	2007	These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	90-93
17130524-8	2007	These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression.	Vitamin D	216-225	vitamin D receptor	Homo sapiens	90-93
17130524-8	2007	These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression.	Vitamin D	216-225	vitamin D receptor	Homo sapiens	90-93
17130524-8	2007	These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression.	Vitamin D	216-225	vitamin D receptor	Homo sapiens	90-93
17482806-1	2007	Vitamin D is a seco-steroid hormone with multiple actions in the brain, mediated through the nuclear vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	101-119
17482806-1	2007	Vitamin D is a seco-steroid hormone with multiple actions in the brain, mediated through the nuclear vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	121-124
17078924-1	2007	Hereditary vitamin D resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	77-95
17078924-1	2007	Hereditary vitamin D resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
17115413-1	2007	Vitamin D analogs such as paricalcitol and calcitriol that activate the vitamin D receptor (VDR) provide survival benefit for Stage 5 chronic kidney disease (CKD) patients, possibly associated with a decrease in cardiovascular (CV)-related incidents.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	72-90
17115413-1	2007	Vitamin D analogs such as paricalcitol and calcitriol that activate the vitamin D receptor (VDR) provide survival benefit for Stage 5 chronic kidney disease (CKD) patients, possibly associated with a decrease in cardiovascular (CV)-related incidents.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	92-95
17360250-1	2007	Gc globulin, also called vitamin D-binding protein, is a plasma protein involved in the extracellular actin-scavenger system, vitamin D transport and possibly also other biological activities.	Vitamin D	25-34	GC vitamin D binding protein	Homo sapiens	0-11
17371189-1	2007	Vitamin D(3) needs to be activated into 1,25-dihydroxyvitamin D(3) in order to bind to vitamin D receptor (VDR) for functional responses.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	87-105
17371189-1	2007	Vitamin D(3) needs to be activated into 1,25-dihydroxyvitamin D(3) in order to bind to vitamin D receptor (VDR) for functional responses.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	107-110
17082781-2	2007	VDR functions through the coordinate binding of vitamin D response elements in the DNA and specific coactivator proteins which help to initiate transcription.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	0-3
17223545-6	2007	The results identify new features of vitamin D-regulated enhancers, including their locations at gene loci, the structure of the VDR binding sites located within, their modular nature and their functional activity.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	129-132
17223547-1	2007	The relationship between the A-ring chair conformation of vitamin D compounds and their ability to bind the vitamin D receptor (VDR) has long attracted the attention of many researchers.	Vitamin D	58-67	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	108-126
17223547-1	2007	The relationship between the A-ring chair conformation of vitamin D compounds and their ability to bind the vitamin D receptor (VDR) has long attracted the attention of many researchers.	Vitamin D	58-67	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	128-131
17223547-4	2007	In an attempt to verify the conformation of vitamin D compounds required for binding the VDR we prepared analog 4, characterized by the presence of an axial 1alpha-hydroxy group.	Vitamin D	44-53	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	89-92
17257828-10	2007	Defining the role of hormone D-VDR binding will lead to a better understanding of the vitamin D signal transduction pathway.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	31-34
17275288-9	2007	This data supports a role for 1,25D in heart ECM metabolism and suggests that MMPs and TIMPs expression may be modulated by vitamin D.	Vitamin D	124-133	matrix metallopeptidase 2	Mus musculus	78-82
17123805-0	2007	Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.	Vitamin D	12-21	fibroblast growth factor 23	Mus musculus	82-88
17123805-7	2007	In conclusion, our results indicate that the alterations in mineral and carbohydrate metabolism present in Fgf-23(-/-) mice require an intact vitamin D signaling pathway.	Vitamin D	142-151	fibroblast growth factor 23	Mus musculus	107-113
17118558-7	2007	Similarly, mRNA levels of vitamin D target genes ecac1, cabp-d28k and ncx-1, involved in renal calcium transport were decreased in kidney.	Vitamin D	26-35	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	49-54
17095575-2	2007	We have previously reported a novel class of negative vitamin D response element (nVDRE) called 1alphanVDRE in the human 25(OH)D31alpha-hydroxylase [1alpha(OH)ase] gene by 1alpha,25(OH)2D3-bound VDR.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	83-86
18220741-1	2007	1alpha,25-Dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)], the most active metabolite of vitamin D, exerts its biological effects by binding to a specific intracellular receptor (the vitamin D receptor, VDR) present in target cells.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	196-199
17046242-8	2007	These results suggest that the differential effect of Vitamin D analogs on stimulating intestinal and Caco-2 calcium transport may be in part due to its different effect on stimulating CALB3 and TRPV6 mRNA expression.	Vitamin D	54-63	transient receptor potential cation channel subfamily V member 6	Homo sapiens	195-200
17071612-1	2006	Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	123-141
17071612-1	2006	Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	61-64
17071612-3	2006	Hormone resistance resulted from constitutive overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) that competed with a normally functioning VDR-retinoid X receptor (RXR) dimer for binding to the vitamin D response element (VDRE).	Vitamin D	209-218	retinoid X receptor alpha	Homo sapiens	154-177
17071612-3	2006	Hormone resistance resulted from constitutive overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) that competed with a normally functioning VDR-retinoid X receptor (RXR) dimer for binding to the vitamin D response element (VDRE).	Vitamin D	209-218	retinoid X receptor alpha	Homo sapiens	179-182
17071612-5	2006	When overexpressed in vitamin D-responsive cells, cDNAs for both hnRNPC1 and hnRNPC2 inhibited VDR-VDRE-directed transactivation (28 and 43%, respectively; both p &lt; 0.005).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	95-98
17071612-7	2006	Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2.	Vitamin D	101-110	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	118-123
17071612-7	2006	Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	301-304
21070203-10	2011	Fibroblasts transfected with a vitamin D response element reporter construct and exposed to the active vitamin D metabolite 1,25D showed increased promoter activity indicating VDR functionality in these cells.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	176-179
21070203-10	2011	Fibroblasts transfected with a vitamin D response element reporter construct and exposed to the active vitamin D metabolite 1,25D showed increased promoter activity indicating VDR functionality in these cells.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	176-179
17148678-5	2006	In addition, loss of vitamin D activities from Fgf-23-/- mice reverses the severe hyperphosphatemia to hypophosphatemia, attributable to increased urinary phosphate wasting in Fgf-23-/-/1alpha(OH)ase-/- mice, possibly as a consequence of decreased expression of NaPi2a.	Vitamin D	21-30	fibroblast growth factor 23	Mus musculus	47-53
17148678-5	2006	In addition, loss of vitamin D activities from Fgf-23-/- mice reverses the severe hyperphosphatemia to hypophosphatemia, attributable to increased urinary phosphate wasting in Fgf-23-/-/1alpha(OH)ase-/- mice, possibly as a consequence of decreased expression of NaPi2a.	Vitamin D	21-30	fibroblast growth factor 23	Mus musculus	176-182
21440524-1	2011	Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	22-48
17148678-6	2006	Ablation of vitamin D from Fgf-23-/- mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, suggesting that abnormal mineral ion homeostasis and impaired skeletogenesis in Fgf-23-/- mice are mediated through enhanced vitamin D activities.	Vitamin D	12-21	fibroblast growth factor 23	Mus musculus	27-33
21440524-1	2011	Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	50-53
17148678-6	2006	Ablation of vitamin D from Fgf-23-/- mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, suggesting that abnormal mineral ion homeostasis and impaired skeletogenesis in Fgf-23-/- mice are mediated through enhanced vitamin D activities.	Vitamin D	12-21	fibroblast growth factor 23	Mus musculus	272-278
21440524-2	2011	The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	93-96
17148678-6	2006	Ablation of vitamin D from Fgf-23-/- mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, suggesting that abnormal mineral ion homeostasis and impaired skeletogenesis in Fgf-23-/- mice are mediated through enhanced vitamin D activities.	Vitamin D	317-326	fibroblast growth factor 23	Mus musculus	27-33
17148678-7	2006	In conclusion, using genetic manipulation studies, we have provided evidence for an in vivo inverse correlation between Fgf-23 and vitamin D activities and for the severe skeletal and soft tissue abnormalities of Fgf-23-/- mice being mediated through vitamin D.	Vitamin D	131-140	fibroblast growth factor 23	Mus musculus	120-126
21524386-2	2011	Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	0-18
17148678-7	2006	In conclusion, using genetic manipulation studies, we have provided evidence for an in vivo inverse correlation between Fgf-23 and vitamin D activities and for the severe skeletal and soft tissue abnormalities of Fgf-23-/- mice being mediated through vitamin D.	Vitamin D	251-260	fibroblast growth factor 23	Mus musculus	120-126
21524386-2	2011	Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	20-23
21524386-2	2011	Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	0-18
17148678-7	2006	In conclusion, using genetic manipulation studies, we have provided evidence for an in vivo inverse correlation between Fgf-23 and vitamin D activities and for the severe skeletal and soft tissue abnormalities of Fgf-23-/- mice being mediated through vitamin D.	Vitamin D	251-260	fibroblast growth factor 23	Mus musculus	213-219
21524386-2	2011	Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	20-23
16946007-4	2006	The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad sphere of influence of the vitamin D endocrine system that is defined by the presence of the VDR in over 30 tissue/organs of man.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	57-60
21371954-5	2011	Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell-cycle inhibition, and therefore vitamin D has anti-proliferative and pro-apoptotic effects in cells of many lineages.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	23-41
21371954-5	2011	Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell-cycle inhibition, and therefore vitamin D has anti-proliferative and pro-apoptotic effects in cells of many lineages.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-46
21371954-5	2011	Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell-cycle inhibition, and therefore vitamin D has anti-proliferative and pro-apoptotic effects in cells of many lineages.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	43-46
16946007-4	2006	The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad sphere of influence of the vitamin D endocrine system that is defined by the presence of the VDR in over 30 tissue/organs of man.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	267-270
21123297-1	2011	Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] involves occupancy of vitamin D response elements (VDREs) by the VDRE binding protein (VDRE-BP) or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR).	Vitamin D	53-62	vitamin D receptor	Homo sapiens	205-223
21123297-1	2011	Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] involves occupancy of vitamin D response elements (VDREs) by the VDRE binding protein (VDRE-BP) or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR).	Vitamin D	53-62	vitamin D receptor	Homo sapiens	135-138
17003089-1	2006	CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	38-41
21123297-8	2011	DDIT4, an inhibitor of mTOR signaling, is a direct target for 1,25(OH)(2)D(3) and VDRE-BP, and functions to suppress cell proliferation in response to vitamin D.	Vitamin D	151-160	DNA damage inducible transcript 4	Homo sapiens	0-5
17003089-1	2006	CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	312-315
21042807-3	2011	Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been found to influence vitamin D levels.	Vitamin D	63-72	GC vitamin D binding protein	Homo sapiens	0-25
17003089-1	2006	CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	312-315
21115634-0	2011	A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.	Vitamin D	15-24	CD44 molecule (Indian blood group)	Homo sapiens	79-83
17056528-10	2006	If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3).	Vitamin D	217-226	interleukin 10	Homo sapiens	75-80
21115634-9	2011	The novel Gemini vitamin D analog, BXL0124, represses CD44 expression in MCF10DCIS.com cells in vitro and in xenograft tumors, suggesting an inhibitory role of a Gemini vitamin D derivative on breast cancer stem cells.	Vitamin D	17-26	CD44 molecule (Indian blood group)	Homo sapiens	54-58
17056528-10	2006	If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3).	Vitamin D	217-226	interleukin 10	Homo sapiens	105-110
17056528-10	2006	If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3).	Vitamin D	217-226	interleukin 10 receptor subunit alpha	Homo sapiens	111-117
21169421-1	2011	Vitamin D compounds regulate PTH at the transcriptional level, presumably via binding to the vitamin D receptor (VDR), but the exact mechanism is presently unclear.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	93-111
17056796-1	2006	The major circulating form of vitamin D is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP).	Vitamin D	30-39	GC vitamin D binding protein	Homo sapiens	144-169
21169421-1	2011	Vitamin D compounds regulate PTH at the transcriptional level, presumably via binding to the vitamin D receptor (VDR), but the exact mechanism is presently unclear.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	113-116
17121927-1	2006	The enzyme 24-hydroxylase, also known as CYP24, metabolizes 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and is an established marker of vitamin D activity.	Vitamin D	74-83	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	41-46
21169421-2	2011	We recently reported that the several vitamin D prohormones with low VDR affinity suppressed PTH, even when their activation was inhibited, raising the possibility that their actions may be VDR independent.	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	69-72
21169421-2	2011	We recently reported that the several vitamin D prohormones with low VDR affinity suppressed PTH, even when their activation was inhibited, raising the possibility that their actions may be VDR independent.	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	190-193
21169421-7	2011	These findings 1) are the first direct demonstration of the role of the VDR in regulation of PTH by 1alpha,25(OH)(2)D(3), 2) confirm that the suppressive actions of the vitamin D prohormones are mediated by the VDR, and 3) introduce a novel organ culture model that allows the ex vivo study of the function of parathyroid glands from transgenic animals.	Vitamin D	169-178	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	72-75
16563362-4	2006	Expression and nuclear activation of the vitamin D receptor (VDR) are necessary for the effects of vitamin D.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	61-64
21169421-7	2011	These findings 1) are the first direct demonstration of the role of the VDR in regulation of PTH by 1alpha,25(OH)(2)D(3), 2) confirm that the suppressive actions of the vitamin D prohormones are mediated by the VDR, and 3) introduce a novel organ culture model that allows the ex vivo study of the function of parathyroid glands from transgenic animals.	Vitamin D	169-178	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	211-214
16914732-8	2006	An evolutionarily conserved region within the human RANKL gene contained a similar vitamin D response element and exhibited an equivalent behavior.	Vitamin D	83-92	TNF superfamily member 11	Homo sapiens	52-57
21383962-1	2011	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.	Vitamin D	149-158	fibroblast growth factor 23	Homo sapiens	12-39
21383962-1	2011	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.	Vitamin D	149-158	fibroblast growth factor 23	Homo sapiens	41-47
16883034-3	2006	Vitamin D deficiency/insensitivity induces type 2 diabetes through impaired insulin secretion involving VDR on pancreatic beta cells, as well as type 1 diabetes through the reduction in immuno-modulatory action of 1,25 (OH)(2) vitamin D.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	104-107
21383962-1	2011	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.	Vitamin D	184-193	fibroblast growth factor 23	Homo sapiens	12-39
21383962-1	2011	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.	Vitamin D	184-193	fibroblast growth factor 23	Homo sapiens	41-47
21383962-1	2011	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.	Vitamin D	314-323	fibroblast growth factor 23	Homo sapiens	12-39
21383962-1	2011	BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia.	Vitamin D	314-323	fibroblast growth factor 23	Homo sapiens	41-47
21852710-7	2011	These findings help provide a biological explanation for the increased risk of more rapid disease progression observed in HIV-infected persons with low levels of vitamin D or with genetic variants within the vitamin D receptor that alter binding to vitamin D.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	208-226
16735491-1	2006	CONTEXT: Fibroblast growth factor 23 (FGF-23) is important in the regulation of phosphorus and vitamin D metabolism.	Vitamin D	95-104	fibroblast growth factor 23	Homo sapiens	9-36
21991434-5	2011	Vitamin D"s antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR), and VDR-regulated genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	162-180
21991434-5	2011	Vitamin D"s antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR), and VDR-regulated genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	182-185
21991434-5	2011	Vitamin D"s antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR), and VDR-regulated genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	192-195
16735491-1	2006	CONTEXT: Fibroblast growth factor 23 (FGF-23) is important in the regulation of phosphorus and vitamin D metabolism.	Vitamin D	95-104	fibroblast growth factor 23	Homo sapiens	38-44
16815434-2	2006	Activated vitamin D(3) (1alpha,25-dihydroxyvitamin D(3)) or calcitriol, decreases peak force and activates protein kinase C (PKC) in isolated perfused hearts.	Vitamin D	10-19	protein kinase C, gamma	Rattus norvegicus	107-123
21865732-2	2011	Klotho overexpression lowers and Klotho deficiency increases the plasma phosphate concentration, effects in part attributed to an inhibitory effect of Klotho on the formation of 1,25-dihydroxycholecalciferol (1,25(OH) (2)D(3)), the active form of Vitamin D.	Vitamin D	247-256	klotho	Mus musculus	0-6
16815434-2	2006	Activated vitamin D(3) (1alpha,25-dihydroxyvitamin D(3)) or calcitriol, decreases peak force and activates protein kinase C (PKC) in isolated perfused hearts.	Vitamin D	10-19	protein kinase C, gamma	Rattus norvegicus	125-128
16835013-1	2006	The nuclear receptor for Vitamin D (VDR) mediates many of the effects of Vitamin D in target tissues by regulating gene expression.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	36-39
21269569-1	2011	Most of the biological actions of vitamin D are mediated by an intracellular receptor (VDR) in which several single nucleotide gene polymorphisms have been identified.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	87-90
20966550-9	2011	Administration of vitamin D to this model protected neurons by preventing cytotoxicity and apoptosis, and also by downregulating LVSCC A1C and upregulating VDR.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	156-159
16835013-1	2006	The nuclear receptor for Vitamin D (VDR) mediates many of the effects of Vitamin D in target tissues by regulating gene expression.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	36-39
16886663-12	2006	The data clearly indicate that agents which inhibit the major vitamin D catabolizing enzyme, CYP24 (24 hydroxylase), potentiate calcitriol killing of prostate tumor cells in vitro and in vivo.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	93-98
16624609-7	2006	In this brief review, the role of vitamin D activation through its vitamin D receptor will serve as an introduction to the magnitude of the nutritional deficits in children, adults, and those with CKD.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	67-85
20943786-7	2011	Vitamin D deficiency or insufficiency was slightly more prevalent in diabetic subjects with albuminuria, coincident with the increase in urine VDBP excretion.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	143-147
20943786-8	2011	CONCLUSIONS: These findings suggest that, theoretically, exaggerated urinary loss of VDBP in T1D, particularly in persons with albuminuria, could contribute mechanistically to vitamin D deficiency in this disease.	Vitamin D	176-185	GC vitamin D binding protein	Homo sapiens	85-89
16362534-2	2006	TRPV6 mRNA expression is strongly regulated by 1,25-dihydroxyvitamin D (1,25VD), the active hormonal form of vitamin D, in intestine and in Caco-2 cells, a human colon cancer cell line.	Vitamin D	61-70	transient receptor potential cation channel subfamily V member 6	Homo sapiens	0-5
22145479-0	2011	Report of two unrelated patients with hereditary vitamin D resistant rickets due to the same novel mutation in the vitamin D receptor.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	115-133
22145480-3	2011	Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	74-92
22145480-3	2011	Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	94-97
16868893-0	2006	Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves" disease and the vitamin D status in a Polish population study.	Vitamin D	93-102	GC vitamin D binding protein	Homo sapiens	0-25
16868893-1	2006	OBJECTIVE: Vitamin D-binding protein (DBP) genetic variants have an influence on vitamin D status and, therefore, they may contribute to the development of autoimmune diseases.	Vitamin D	81-90	GC vitamin D binding protein	Homo sapiens	11-36
16753019-2	2006	Transfection studies suggest dissociated effects of VDR gene mutations on the regulation of genes involved in vitamin D metabolism and dendritic cell maturation.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	52-55
20955794-2	2011	The anticancer effects of vitamin D are mediated primarily by its active metabolite, 1,25-dihydroxyvitamin D (calcitriol), through vitamin D receptor (VDR) signaling.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	131-149
20955794-2	2011	The anticancer effects of vitamin D are mediated primarily by its active metabolite, 1,25-dihydroxyvitamin D (calcitriol), through vitamin D receptor (VDR) signaling.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	151-154
16753019-4	2006	MATERIALS AND METHODS: The VDR gene was analyzed in a child with vitamin D-resistant rickets, total alopecia, and early childhood-onset type 1 diabetes.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	27-30
20955794-10	2011	Future large studies to replicate our findings and to assess the impact of VDR gene polymorphisms on VDR expression are required as therapies targeting the vitamin D signaling pathway may be influenced by VDR status in the target lung cancer tissue.	Vitamin D	156-165	vitamin D receptor	Homo sapiens	101-104
16753019-7	2006	Both mutations significantly impaired VDR ligand-binding capacity but had dissociated effects on CYP-24 and RelB promoter responses to vitamin D.	Vitamin D	135-144	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	97-103
20955794-10	2011	Future large studies to replicate our findings and to assess the impact of VDR gene polymorphisms on VDR expression are required as therapies targeting the vitamin D signaling pathway may be influenced by VDR status in the target lung cancer tissue.	Vitamin D	156-165	vitamin D receptor	Homo sapiens	101-104
16481392-7	2006	The activation by 1,25(OH)(2)D(3) was abrogated after site-directed mutagenesis or deletion of the vitamin D response element (VDRE) in the ASBT promoter.	Vitamin D	99-108	solute carrier family 10 member 2	Rattus norvegicus	140-144
20714323-0	2011	Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action.	Vitamin D	0-9	CEA cell adhesion molecule 1	Homo sapiens	19-26
20714323-0	2011	Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action.	Vitamin D	0-9	insulin like growth factor 1 receptor	Homo sapiens	46-60
16735766-1	2006	The aim of this study was to compare the bone mineral density (BMD) of two different treatment regimens in infants with nutritional vitamin D deficient rickets (VDR).	Vitamin D	132-141	vitamin D receptor	Homo sapiens	161-164
21629267-3	2011	Here we show that MS risk modulators converge to alter N-glycosylation and/or CTLA-4 surface retention conditional on metabolism and vitamin D(3), including genetic variants in interleukin-7 receptor-alpha (IL7RA*C), interleukin-2 receptor-alpha (IL2RA*T), MGAT1 (IV(A)V(T-T)) and CTLA-4 (Thr17Ala).	Vitamin D	133-142	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	78-84
20974859-8	2010	Our results suggest a novel, post-transcriptional mechanism whereby Th17 cytokines are inhibited by VDR, which may underscore future therapeutic usage of vitamin D in treatment of autoimmune diseases.	Vitamin D	154-163	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	100-103
16597685-0	2006	Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.	Vitamin D	77-86	fibroblast growth factor 23	Mus musculus	0-27
16597685-6	2006	Overexpression of a dominant negative vitamin D receptor inhibited 1,25(OH)(2)D(3) stimulation of FGF23 promoter activity, and mutagenesis of the FGF23 promoter identified a vitamin D-responsive element (-1180 GGAACTcagTAACCT -1156) that is responsible for the vitamin D effects.	Vitamin D	38-47	fibroblast growth factor 23	Mus musculus	98-103
20847308-0	2010	Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification.	Vitamin D	19-28	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	45-52
16597685-6	2006	Overexpression of a dominant negative vitamin D receptor inhibited 1,25(OH)(2)D(3) stimulation of FGF23 promoter activity, and mutagenesis of the FGF23 promoter identified a vitamin D-responsive element (-1180 GGAACTcagTAACCT -1156) that is responsible for the vitamin D effects.	Vitamin D	174-183	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	38-56
16597685-6	2006	Overexpression of a dominant negative vitamin D receptor inhibited 1,25(OH)(2)D(3) stimulation of FGF23 promoter activity, and mutagenesis of the FGF23 promoter identified a vitamin D-responsive element (-1180 GGAACTcagTAACCT -1156) that is responsible for the vitamin D effects.	Vitamin D	174-183	fibroblast growth factor 23	Mus musculus	146-151
16597685-8	2006	The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D.	Vitamin D	137-146	fibroblast growth factor 23	Mus musculus	24-29
16609009-6	2006	Combinations of vitamin D(3) compounds with TSA restored VDR antiproliferative signaling (target gene regulation, cell cycle arrest, and antiproliferative effects in liquid culture) to levels which were indistinguishable from MCF-12A cells.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	57-60
21143098-2	2010	Vitamin D has been shown to exert multiple immunomodulatory effects, which act through its own receptor (vitamin D receptor).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	105-123
16427152-1	2006	Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	104-122
21113195-1	2010	Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	162-180
21113195-1	2010	Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	182-185
16427152-1	2006	Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	124-127
16427152-4	2006	Given the important role of Vitamin D and VDR in brain development and functioning, we hypothesized that several other important behavioural domains may be affected by disruption of the VDR gene in mice.	Vitamin D	28-37	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	186-189
16517748-8	2006	The basal IL-18 expression and activity were much higher in VDR(-/-) keratinocytes and skin, underscoring the importance of the repressive role of vitamin D in IL-18 production.	Vitamin D	147-156	interleukin 18	Homo sapiens	10-15
21037388-7	2010	Indeed,FGF23 is secreted from bone and is circulated to kidney where FGF23 tranceduces signals that suppress vitamin D synthesis and phosphate reabsorption fgf23 deficient phenotypes were reminiscent of those of mice lacking the alpha-kl gene, which led us the discovery of molecular interaction and functional crosstalk of alpha-Kl and FGF23.	Vitamin D	109-118	fibroblast growth factor 23	Mus musculus	7-12
16517748-8	2006	The basal IL-18 expression and activity were much higher in VDR(-/-) keratinocytes and skin, underscoring the importance of the repressive role of vitamin D in IL-18 production.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	60-63
21037388-7	2010	Indeed,FGF23 is secreted from bone and is circulated to kidney where FGF23 tranceduces signals that suppress vitamin D synthesis and phosphate reabsorption fgf23 deficient phenotypes were reminiscent of those of mice lacking the alpha-kl gene, which led us the discovery of molecular interaction and functional crosstalk of alpha-Kl and FGF23.	Vitamin D	109-118	fibroblast growth factor 23	Mus musculus	69-74
16517748-8	2006	The basal IL-18 expression and activity were much higher in VDR(-/-) keratinocytes and skin, underscoring the importance of the repressive role of vitamin D in IL-18 production.	Vitamin D	147-156	interleukin 18	Homo sapiens	160-165
21037388-7	2010	Indeed,FGF23 is secreted from bone and is circulated to kidney where FGF23 tranceduces signals that suppress vitamin D synthesis and phosphate reabsorption fgf23 deficient phenotypes were reminiscent of those of mice lacking the alpha-kl gene, which led us the discovery of molecular interaction and functional crosstalk of alpha-Kl and FGF23.	Vitamin D	109-118	fibroblast growth factor 23	Mus musculus	69-74
16517748-10	2006	Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes.	Vitamin D	41-50	interleukin 18	Homo sapiens	173-178
16516540-8	2006	Our findings suggest that CYP24A1 can activate and inactivate vitamin D prodrugs in skin and other target cells in vitro, offering the potential for treatment of hyperproliferative disorders such as psoriasis by topical administration of these prodrugs.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	26-33
20684976-11	2010	Deficiency in vitamin D may provide an etiologic link between the long-known ecologic findings regarding latitude and the basic science noting polymorphisms in the vitamin D receptor.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	164-182
16629532-2	2006	One risk factor is reported to be vitamin D (VD) and therefore the function of its receptor (VDR) could be of importance.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	93-96
20736230-2	2010	However, the mode of action of vitamin D, through its cognate nuclear vitamin D receptor (VDR), and its contribution to diverse disorders, remain poorly understood.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	70-88
20736230-2	2010	However, the mode of action of vitamin D, through its cognate nuclear vitamin D receptor (VDR), and its contribution to diverse disorders, remain poorly understood.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	90-93
20800785-11	2010	Vitamin D also increases synthesis of interleukin 10 by CD4+CD25+Foxp3+ T-regulatory cells and dendritic cells, while concurrently inhibiting dendritic cell activation by downregulating expression of costimulatory molecules CD40 and CD80/86.	Vitamin D	0-9	interleukin 10	Homo sapiens	38-52
20800785-14	2010	CONCLUSIONS: We hypothesize that vitamin D supplementation may lead to improved asthma control by inhibiting the influx of inflammatory cytokines in the lung and increasing the secretion of interleukin 10 by T-regulatory cells and dendritic cells.	Vitamin D	33-42	interleukin 10	Homo sapiens	190-204
16408109-5	2006	These studies are revealing functions of the vitamin D/VDR system which have relevance for new concepts of the pathophysiology of renal bone disease and, in particular, of the adynamic bone disorder, and for the development of new analogs of the active form of vitamin D, which have less calcemic activity and greater skeletal anabolic effects.	Vitamin D	261-270	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	55-58
17237620-10	2006	CYP24 is a key enzyme involved in the breakdown of vitamin D.	Vitamin D	51-60	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	0-5
16141393-3	2005	Using constitutively expressed heat shock protein-70 (hsc70) as chaperone, here we demonstrate that vitamin D metabolite binding to hsc70 is also ATP dependent.	Vitamin D	100-109	heat shock protein family A (Hsp70) member 8	Homo sapiens	31-52
16141393-3	2005	Using constitutively expressed heat shock protein-70 (hsc70) as chaperone, here we demonstrate that vitamin D metabolite binding to hsc70 is also ATP dependent.	Vitamin D	100-109	heat shock protein family A (Hsp70) member 8	Homo sapiens	54-59
16141393-3	2005	Using constitutively expressed heat shock protein-70 (hsc70) as chaperone, here we demonstrate that vitamin D metabolite binding to hsc70 is also ATP dependent.	Vitamin D	100-109	heat shock protein family A (Hsp70) member 8	Homo sapiens	132-137
16141393-6	2005	In solution, the binding of 25-hydroxylated vitamin D metabolites to hsc70 was significantly increased (P &lt; 0.01) in the presence of ATP and a nonmetabolizable ATP analog.	Vitamin D	44-53	heat shock protein family A (Hsp70) member 8	Homo sapiens	69-74
16141393-8	2005	These results suggest that ATP hydrolysis to ADP would favor the release of vitamin D from a donor hsc70 molecule at a time when an hsc70-bound acceptor protein substrate is anchored to the chaperone with relative avidity.	Vitamin D	76-85	heat shock protein family A (Hsp70) member 8	Homo sapiens	99-104
16141393-8	2005	These results suggest that ATP hydrolysis to ADP would favor the release of vitamin D from a donor hsc70 molecule at a time when an hsc70-bound acceptor protein substrate is anchored to the chaperone with relative avidity.	Vitamin D	76-85	heat shock protein family A (Hsp70) member 8	Homo sapiens	132-137
16141393-9	2005	We theorize that the endogenous ATPase activity of hsc70 promotes the transfer of vitamin D sterols to other intracellular vitamin D binding proteins, such as the vitamin D receptor and vitamin D hydroxylases, to which hsc70 is known to bind.	Vitamin D	82-91	heat shock protein family A (Hsp70) member 8	Homo sapiens	51-56
16141393-9	2005	We theorize that the endogenous ATPase activity of hsc70 promotes the transfer of vitamin D sterols to other intracellular vitamin D binding proteins, such as the vitamin D receptor and vitamin D hydroxylases, to which hsc70 is known to bind.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	163-181
16141393-9	2005	We theorize that the endogenous ATPase activity of hsc70 promotes the transfer of vitamin D sterols to other intracellular vitamin D binding proteins, such as the vitamin D receptor and vitamin D hydroxylases, to which hsc70 is known to bind.	Vitamin D	82-91	heat shock protein family A (Hsp70) member 8	Homo sapiens	219-224
16292192-0	2005	[FGF23, a "new" hormone regulating phosphate homeostasis and vitamin D metabolism].	Vitamin D	61-70	fibroblast growth factor 23	Homo sapiens	1-6
16292192-6	2005	It is now established that FGF23 regulates not only phosphate homeostasis, but also vitamin D metabolism.	Vitamin D	84-93	fibroblast growth factor 23	Homo sapiens	27-32
16234967-4	2005	INTRODUCTION: Fibroblast growth factor (FGF)-23 is a recently described hormone that has been shown to be involved in the regulation of phosphate and vitamin D metabolism.	Vitamin D	150-159	fibroblast growth factor 23	Homo sapiens	14-47
16358222-4	2005	Klotho plays a critical role in the regulation of calcium and phosphorus homeostasis by negatively regulating active vitamin D synthesis.	Vitamin D	117-126	klotho	Homo sapiens	0-6
16002434-2	2005	The vitamin D receptor (VDR) is a ligand-regulated transcription factor that recognizes cognate vitamin D response elements (VDREs) formed by direct or everted repeats of PuG(G/T)TCA motifs separated by 3 or 6 bp (DR3 or ER6).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
16239345-11	2005	We conclude that vitamin D-regulated relB transcription in DCs is controlled by chromatin remodeling by means of recruitment of complexes including HDAC3.	Vitamin D	17-26	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	37-41
16181450-8	2005	The active form of vitamin D, 1,25-dihydroxyvitamin D(3), exhibits antiproliferative and immunoregulatory effects via the vitamin D receptor, and thus is successfully used in the topical treatment of psoriasis.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	122-140
16177194-10	2005	The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice.	Vitamin D	108-117	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	35-38
16177194-10	2005	The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice.	Vitamin D	152-161	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	35-38
16278149-1	2005	OBJECTIVE: Vitamin D has been shown to exert multiple immunomodulatory effects and is known to suppress T-cell activation by binding to the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	140-158
16278149-1	2005	OBJECTIVE: Vitamin D has been shown to exert multiple immunomodulatory effects and is known to suppress T-cell activation by binding to the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	160-163
16076372-1	2005	Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR).	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	0-27
16076372-1	2005	Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR).	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	29-34
16076372-1	2005	Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR).	Vitamin D	103-112	fibroblast growth factor 23	Homo sapiens	155-160
15995295-1	2005	Fibroblast growth factor (FGF) 23 was recently shown to alter serum phosphate level by modulating renal tubular phosphate reabsorption and production of active vitamin D independently of parathyroid hormone action.	Vitamin D	160-169	fibroblast growth factor 23	Mus musculus	0-33
16076355-5	2005	Vitamin D analogs with selective VDR activity (such as paricalcitol) have great potential for preventing parathyroid hyperplasia and bone loss in early CKD without adversely affecting kidney function.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	33-36
16083553-1	2005	OBJECTIVE: To study the association between vitamin D receptor (VDR) gene Apa I polymorphism and vitamin D deficiency rickets in children of Shanxi Han ethnic group, and to explore the significance of individual hereditary factors in the development of rickets.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	64-67
15671080-0	2005	Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	33-60
15671080-1	2005	Fibroblast growth factor-23 (FGF-23) has been recently identified as playing an important pathophysiological role in phosphate homeostasis and vitamin D metabolism.	Vitamin D	143-152	fibroblast growth factor 23	Homo sapiens	0-27
15671080-1	2005	Fibroblast growth factor-23 (FGF-23) has been recently identified as playing an important pathophysiological role in phosphate homeostasis and vitamin D metabolism.	Vitamin D	143-152	fibroblast growth factor 23	Homo sapiens	29-35
15671080-9	2005	The presents study demonstrated that vitamin D and the plasma phosphate level are important regulators of the transcription of the mouse FGF-23 gene.	Vitamin D	37-46	fibroblast growth factor 23	Mus musculus	137-143
15869926-12	2005	Thus, our results demonstrate that Fgf23 is independently regulated by phosphate and by vitamin D.	Vitamin D	88-97	fibroblast growth factor 23	Mus musculus	35-40
15888147-6	2005	The addition of retinoids or corticosteroids to the cell culture inhibited the UVB-induced suppression of both ATP2A2 and ATP2C1 mRNA levels, and UVB-induced suppression of ATP2C1 mRNA was also inhibited by the addition of ciclosporin, tacrolimus and vitamin D(3).	Vitamin D	251-260	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	173-179
15867263-3	2005	EXPERIMENTAL DESIGN: Quantitative reverse transcription-PCR analysis of mRNA expression was carried out for the vitamin D-activating enzyme 1alpha-hydroxylase, the catabolic enzyme 24-hydroxylase, and the vitamin D receptor in 41 tumors and paired nonneoplastic tissue as well as breast cancer cell lines.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	205-223
15860047-8	2005	CONCLUSIONS: ZK156979 is a member of novel vitamin D analogues revealing prominent immunomodulatory and suppressive characteristics with distinctive inhibition of Th1-cytokines whereas the Th2 compartment is augmented, thus providing a considerable therapeutic potential in T-cell -mediated diseases.	Vitamin D	43-52	negative elongation factor complex member C/D	Homo sapiens	163-166
15891005-4	2005	Treatment with active vitamin D can increase vitamin D receptor expression, inhibit growth of parathyroid tumors, and reduce PTH levels in patients with hyperparathyroidism (HPT).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	45-63
15752725-1	2005	Recently, epimerization of the hydroxyl group at C-3 has been identified as a unique metabolic pathway of vitamin D compounds.	Vitamin D	106-115	complement C3	Homo sapiens	49-52
15816836-7	2005	Finally, quantitative differences in gene expression revealed a vitamin D-regulated differentiation network and identified peptidylarginine deiminases, kallikreins, serine proteinase inhibitor family members, Kruppel-like factor 4, and c-fos as vitamin D-responsive genes, whose protein products may play an important role in epidermal differentiation in normal and diseased state.	Vitamin D	64-73	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	236-241
15816836-7	2005	Finally, quantitative differences in gene expression revealed a vitamin D-regulated differentiation network and identified peptidylarginine deiminases, kallikreins, serine proteinase inhibitor family members, Kruppel-like factor 4, and c-fos as vitamin D-responsive genes, whose protein products may play an important role in epidermal differentiation in normal and diseased state.	Vitamin D	245-254	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	236-241
15769857-2	2005	Renal and parathyroid gland VDR content is an important factor in calcium homeostasis, vitamin D metabolism, and the treatment of secondary hyperparathyroidism and renal osteodystrophy.	Vitamin D	87-96	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	28-31
15769857-3	2005	In these tissues, VDR expression is highly regulated by the calcium and vitamin D status.	Vitamin D	72-81	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	18-21
15727633-1	2005	BACKGROUND: 1alpha,25-dihydroxyvitamin D(3)[1,25(OH)(2)D(3)], the active metabolite of vitamin D, exerts its activities by binding to the vitamin D receptor (VDR) with subsequent function as a transcription factor.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	138-156
15727633-1	2005	BACKGROUND: 1alpha,25-dihydroxyvitamin D(3)[1,25(OH)(2)D(3)], the active metabolite of vitamin D, exerts its activities by binding to the vitamin D receptor (VDR) with subsequent function as a transcription factor.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	158-161
15683428-3	2005	Vitamin D has been shown to exert multiple immunomodulatory effects, which acts through its own receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	106-109
15581603-4	2005	Renal VDR levels were significantly higher in the vitamin D-deficient mice fed the 0.47% calcium diet vs. the calcium-restricted diet, and were increased 5-fold by 1,25(OH)(2)D(3) when dietary calcium was present.	Vitamin D	50-59	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	6-9
15733015-1	2005	Paricalcitol (Zemplar) is a synthetic vitamin D(2) analogue that inhibits the secretion of parathyroid hormone (PTH) through binding to the vitamin D receptor.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	140-158
15574355-13	2005	The species-based difference was also observed in the metabolism of vitamin D analogs by CYP24A1, suggesting that the recombinant system for human CYP24A1 may be of great use for the prediction of the metabolism of vitamin D analogs in humans.	Vitamin D	215-224	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	147-154
15838626-2	2005	Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism.	Vitamin D	110-119	fibroblast growth factor 23	Homo sapiens	10-37
15838626-2	2005	Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism.	Vitamin D	110-119	fibroblast growth factor 23	Homo sapiens	39-45
15838626-12	2005	These data suggested that FGF-23 is a possible causal factor for hypophosphatemia and abnormal vitamin D metabolism in MAS.	Vitamin D	95-104	fibroblast growth factor 23	Homo sapiens	26-32
15956805-3	2005	Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy.	Vitamin D	37-46	fibroblast growth factor 23	Homo sapiens	6-12
15956805-11	2005	Extremely high levels of serum FGF-23 in these patients may be attributed, at least in part, to the cumulative dose of vitamin D.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	31-37
15585794-1	2004	1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3[, the biologically active form of vitamin D that interacts with the vitamin D receptor (VDR), is a coordinate regulator of proliferation, differentiation, and survival of breast cancer cells.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	111-129
15585794-1	2004	1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3[, the biologically active form of vitamin D that interacts with the vitamin D receptor (VDR), is a coordinate regulator of proliferation, differentiation, and survival of breast cancer cells.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	131-134
15659793-8	2004	Osteocalcin gene expression was enhanced by VD/VD-R through the vitamin D-responsive element in the promoter.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	47-51
15605102-1	2004	OBJECTIVE: To study the expression of osteoprotegerin(OPG) and receptor activator nuclear factor kappa B ligand(RANKL) at protein level in human periodontal ligament cells (HPDLCs), and the effect of 1alpha,25(OH)(2) vitamin D(3) [1,25(OH)(2)vitD(3)] on the secretion of OPG protein in vitro.	Vitamin D	217-226	TNF superfamily member 11	Homo sapiens	112-117
15570014-1	2004	Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	169-187
15570014-1	2004	Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	189-192
15570014-1	2004	Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	252-255
15474498-6	2004	In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation.	Vitamin D	159-168	vitamin D receptor	Homo sapiens	82-86
20507957-1	2010	The discovery of fibroblast growth factor 23 (FGF23) has clarified much of our understanding of abnormalities in phosphorus and vitamin D metabolism in chronic kidney disease (CKD).	Vitamin D	128-137	fibroblast growth factor 23	Homo sapiens	17-44
20507957-1	2010	The discovery of fibroblast growth factor 23 (FGF23) has clarified much of our understanding of abnormalities in phosphorus and vitamin D metabolism in chronic kidney disease (CKD).	Vitamin D	128-137	fibroblast growth factor 23	Homo sapiens	46-51
20507957-7	2010	In addition, given that treatment with activated vitamin D compounds stimulates FGF23, these data have raised important new questions about the optimal use of activated vitamin D compounds in the management of bone and mineral disorders in CKD.	Vitamin D	49-58	fibroblast growth factor 23	Homo sapiens	80-85
15474498-6	2004	In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation.	Vitamin D	159-168	retinoid X receptor alpha	Homo sapiens	94-113
20711952-8	2010	Vitamin D stimulates ovarian steroidogenesis and IGFBP-1 production in human ovarian cells likely acting via vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	109-127
15474498-6	2004	In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation.	Vitamin D	159-168	retinoid X receptor alpha	Homo sapiens	115-118
15876428-0	2004	Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	108-111
15876428-0	2004	Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	108-111
20407924-5	2010	Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	23-41
20407924-5	2010	Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-46
15876428-2	2004	Vitamin D receptor (VDR) belongs to a nuclear receptor super-family that mediates the genomic actions of vitamin D3 and regulates gene expression by binding with vitamin D response elements in the promoter region of the cognate gene.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	0-18
20407924-5	2010	Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	43-46
15876428-2	2004	Vitamin D receptor (VDR) belongs to a nuclear receptor super-family that mediates the genomic actions of vitamin D3 and regulates gene expression by binding with vitamin D response elements in the promoter region of the cognate gene.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	20-23
20394945-3	2010	Vitamin D receptor expression (VDR), 24-hydroxylase activity, and functional gene polymorphisms of vitamin D metabolism regulators VDR(rs4516035), 1-hydroxylase(rs10877012), 24-hydroxylase(rs2248359), FGF23(rs7955866), Klotho(rs9536314, rs564481, rs648202), were evaluated.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	131-134
15489002-0	2004	Characterization of vitamin D-mediated induction of the CYP 24 transcription.	Vitamin D	20-29	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	56-62
20394945-3	2010	Vitamin D receptor expression (VDR), 24-hydroxylase activity, and functional gene polymorphisms of vitamin D metabolism regulators VDR(rs4516035), 1-hydroxylase(rs10877012), 24-hydroxylase(rs2248359), FGF23(rs7955866), Klotho(rs9536314, rs564481, rs648202), were evaluated.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	201-206
20493879-4	2010	In silico screening of the MYC gene locus identified six putative binding sites [vitamin D response elements (VDREs)] for the vitamin D receptor (VDR).	Vitamin D	81-90	vitamin D receptor	Homo sapiens	126-144
20493879-4	2010	In silico screening of the MYC gene locus identified six putative binding sites [vitamin D response elements (VDREs)] for the vitamin D receptor (VDR).	Vitamin D	81-90	vitamin D receptor	Homo sapiens	110-113
15252846-1	2004	The vitamin D receptor (VDR) may importantly modulate risk of colorectal cancer either independently or in conjunction with calcium and vitamin D intake.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
20583336-4	2010	Finally, new data demonstrate the ability to alter FGF23 levels using common CKD therapies such as phosphate binders, active vitamin D, and cinacalcet.	Vitamin D	125-134	fibroblast growth factor 23	Homo sapiens	51-56
15377346-8	2004	Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression.	Vitamin D	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
20459364-4	2010	The FGF23-klotho system not only affects phosphate homeostasis but can also influence parathyroid hormone (PTH) and vitamin D activities.	Vitamin D	116-125	fibroblast growth factor 23	Mus musculus	4-9
20459364-4	2010	The FGF23-klotho system not only affects phosphate homeostasis but can also influence parathyroid hormone (PTH) and vitamin D activities.	Vitamin D	116-125	klotho	Mus musculus	10-16
20459364-6	2010	Vitamin D is a strong inducer of both FGF23 and klotho expression, while FGF23 can suppress the renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity.	Vitamin D	0-9	fibroblast growth factor 23	Mus musculus	38-43
20459364-6	2010	Vitamin D is a strong inducer of both FGF23 and klotho expression, while FGF23 can suppress the renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity.	Vitamin D	0-9	klotho	Mus musculus	48-54
20459364-7	2010	An understanding of the complex interactions of phosphate, vitamin D and PTH with the FGF23-klotho system has paved the way to explore the therapeutic benefits of modulating the FGF23-klotho system in diseases associated with abnormal mineral ion balance.	Vitamin D	59-68	fibroblast growth factor 23	Mus musculus	86-91
20459364-7	2010	An understanding of the complex interactions of phosphate, vitamin D and PTH with the FGF23-klotho system has paved the way to explore the therapeutic benefits of modulating the FGF23-klotho system in diseases associated with abnormal mineral ion balance.	Vitamin D	59-68	klotho	Mus musculus	92-98
20427486-2	2010	Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear.	Vitamin D	5-14	GC vitamin D binding protein	Homo sapiens	46-71
15377346-8	2004	Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression.	Vitamin D	27-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-226
15377346-8	2004	Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression.	Vitamin D	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	238-243
15326291-4	2004	Data obtained from docking five different vitamin D sterols in the genomic and alternative pockets were used to generate a receptor conformational ensemble model, providing an explanation for how VDR and possibly the estrogen receptor can have genomic and NG functionality.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	196-199
20182414-2	2010	Upon binding of the ligand, the vitamin D receptor heterodimerizes with the retinoid X receptor and binds to vitamin D response elements in the promoter region of target genes to induce/repress their expression.	Vitamin D	32-41	retinoid X receptor alpha	Homo sapiens	76-95
20407479-8	2010	Thus we found that FGF23 likely has an important role in pediatric calcium and phosphate homeostasis, and in vitamin D metabolism, even at an early stage of CKD.	Vitamin D	109-118	fibroblast growth factor 23	Homo sapiens	19-24
20392825-7	2010	Immunohistochemistry confirmed that colonic angiogenin-4 protein was significantly decreased in vitamin D-deficient mice even in the absence of colitis.	Vitamin D	96-105	angiogenin, ribonuclease A family, member 4	Mus musculus	44-56
20172873-1	2010	BACKGROUND: The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
20119827-2	2010	The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	157-175
20119827-2	2010	The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	177-180
20119827-2	2010	The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system.	Vitamin D	157-166	vitamin D receptor	Homo sapiens	177-180
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	319-328	vitamin D receptor	Homo sapiens	47-50
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	319-328	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	76-83
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	319-328	vitamin D receptor	Homo sapiens	88-91
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	319-328	vitamin D receptor	Homo sapiens	88-91
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	436-445	vitamin D receptor	Homo sapiens	47-50
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	436-445	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	76-83
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	436-445	vitamin D receptor	Homo sapiens	88-91
20206692-4	2010	The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance.	Vitamin D	436-445	vitamin D receptor	Homo sapiens	88-91
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Vitamin D	249-258	vitamin D receptor	Homo sapiens	90-93
20406950-3	2010	It is known that the interaction of the vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25D) with its functional vitamin D receptor leads to differentiation, G(1) arrest, and increased cell survival in p53-null AML cells.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	116-134
20177401-4	2010	Recent findings also indicate that fibroblast growth factor 23 has feedback mechanisms involving parathyroid hormone and vitamin D that control phosphate homeostasis.	Vitamin D	121-130	fibroblast growth factor 23	Homo sapiens	35-62
20012997-1	2010	Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD).	Vitamin D	120-129	fibroblast growth factor 23	Homo sapiens	48-75
20012997-1	2010	Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD).	Vitamin D	120-129	fibroblast growth factor 23	Homo sapiens	77-83
20184548-0	2010	The vitamin D/CYP24A1 story in cancer.	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	14-21
20160035-8	2010	Although OPG treatment reduced the size of radiographic osteolyses and tumor area in both groups, tumors remained larger in OPG-treated vitamin D-deficient compared with OPG-treated vitamin D-sufficient mice (0.53 +/- 0.05 mm(2) versus 0.19 +/- 0.05 mm2; P &lt; 0.05).	Vitamin D	136-145	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	124-127
20160035-8	2010	Although OPG treatment reduced the size of radiographic osteolyses and tumor area in both groups, tumors remained larger in OPG-treated vitamin D-deficient compared with OPG-treated vitamin D-sufficient mice (0.53 +/- 0.05 mm(2) versus 0.19 +/- 0.05 mm2; P &lt; 0.05).	Vitamin D	136-145	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	124-127
20308705-1	2010	There is increasing evidence for health benefits accomplished by activated vitamin D through interaction with the vitamin D receptor (VDR) that go beyond calcium and bone homeostasis and regulation of parathyroid hormone (PTH) secretion.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	114-132
20308705-1	2010	There is increasing evidence for health benefits accomplished by activated vitamin D through interaction with the vitamin D receptor (VDR) that go beyond calcium and bone homeostasis and regulation of parathyroid hormone (PTH) secretion.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	134-137
15209957-0	2004	Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10.	Vitamin D	4-13	interleukin 10	Homo sapiens	96-110
15209957-2	2004	Experimental data indicate that low cellular availability of the vitamin D hormone 1,25-dihydroxyvitamin D [1,25(OH)2D] results in a down-regulation of IL-10 concentrations.	Vitamin D	65-74	interleukin 10	Homo sapiens	152-157
15225766-4	2004	Using immunohistochemistry, we have now detected nuclear Vitamin D receptor (VDR) immunoreactivity in primary cutaneous malignant melanoma (MM), indicating that Vitamin D metabolites may be of importance for the growth regulation in these tumors.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	77-80
15225769-4	2004	Chromatin immunoprecipitation studies show that NCoA62/SKIP is recruited in a 1,25-(OH)(2)D(3)-dependent manner to native Vitamin D responsive gene promoters and it enters these promoter complexes after VDR and SRC entry.	Vitamin D	122-131	vitamin D receptor	Homo sapiens	203-206
15225769-4	2004	Chromatin immunoprecipitation studies show that NCoA62/SKIP is recruited in a 1,25-(OH)(2)D(3)-dependent manner to native Vitamin D responsive gene promoters and it enters these promoter complexes after VDR and SRC entry.	Vitamin D	122-131	steroid receptor RNA activator 1	Homo sapiens	211-214
15225769-9	2004	They further solidify an important role for VDR/NR-interactors downstream of the transcription process in determining the overall response of Vitamin D and steroid hormone regulated genes.	Vitamin D	142-151	vitamin D receptor	Homo sapiens	44-47
15225833-7	2004	Given the pivotal effects of the Vitamin D receptor on gene transcription, it is likely that the anti-carcinogenic effects of Vitamin D that have previously been described are related to the activity and expression of the Vitamin D receptor and should be investigated further.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	222-240
15225849-8	2004	The differences of phenotype between hypo- and normo-calcemic VDR null mutant mice suggested a specific Vitamin D control of alveolar bone formation by the Vitamin D nuclear receptor pathway.	Vitamin D	104-113	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	62-65
15066918-1	2004	OBJECTIVE: Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	126-144
15066918-1	2004	OBJECTIVE: Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	146-149
14685312-2	2003	Introducing functional groups into the 2[small alpha]-position of the vitamin D-26,23-lactones resulted in remarkable enhancement of their antagonistic activity on vitamin D receptor (VDR).	Vitamin D	70-79	vitamin D receptor	Homo sapiens	164-182
14685312-2	2003	Introducing functional groups into the 2[small alpha]-position of the vitamin D-26,23-lactones resulted in remarkable enhancement of their antagonistic activity on vitamin D receptor (VDR).	Vitamin D	70-79	vitamin D receptor	Homo sapiens	184-187
14635194-0	2003	Membrane actions of vitamin D metabolites 1alpha,25(OH)2D3 and 24R,25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout mice.	Vitamin D	20-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-145
14506229-4	2003	A DR3-type vitamin D response element was identified in the fourth exon of GADD45 that forms a complex with the vitamin D receptor.retinoid X receptor heterodimer in electrophoresis mobility shift assays and mediates the dose-dependent induction of luciferase activity by 1,25-dihydroxyvitamin D3 in reporter assays.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	112-130
20408440-11	2010	These results indicate that FGF23 is a hormone regulating phosphate and vitamin D metabolism.	Vitamin D	72-81	fibroblast growth factor 23	Homo sapiens	28-33
14572242-5	2003	The novel analogues efficiently bind VDR in vivo to induce transcription from a consensus vitamin D responsive element (VDRE).	Vitamin D	90-99	vitamin D receptor	Homo sapiens	37-40
20145122-2	2010	The biological actions of the hormonal form of vitamin D, 1,25(OH)(2)D(3), are mediated by the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptors (RXR).	Vitamin D	47-56	vitamin D receptor	Homo sapiens	95-113
20145122-2	2010	The biological actions of the hormonal form of vitamin D, 1,25(OH)(2)D(3), are mediated by the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptors (RXR).	Vitamin D	47-56	vitamin D receptor	Homo sapiens	115-118
14594170-2	2003	in infants with nutritional vitamin D deficiency rickets (VDR).	Vitamin D	28-37	vitamin D receptor	Homo sapiens	58-61
20145122-2	2010	The biological actions of the hormonal form of vitamin D, 1,25(OH)(2)D(3), are mediated by the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptors (RXR).	Vitamin D	47-56	retinoid X receptor alpha	Homo sapiens	148-168
20145122-2	2010	The biological actions of the hormonal form of vitamin D, 1,25(OH)(2)D(3), are mediated by the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptors (RXR).	Vitamin D	47-56	retinoid X receptor alpha	Homo sapiens	170-173
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	85-92
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	277-284
19920212-8	2010	We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress.	Vitamin D	65-74	FK506 binding protein 5	Mus musculus	286-291
14594170-3	2003	Our purpose was to determine the most effective dosage of vitamin D with least side effects for treating VDR.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	105-108
14594170-10	2003	In conclusion, our findings showed that 150,000 IU or 300,000 IU of vitamin D was adequate in the treatment of VDR, but 600,000 IU of vitamin D may carry the risk of hypercalcemia.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	111-114
19735754-9	2010	However, vitamin D supplementation increased whole body bone mineral density (BMD) (p=0.007) and bone mineral content (BMC) (p=0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	144-147
19735754-9	2010	However, vitamin D supplementation increased whole body bone mineral density (BMD) (p=0.007) and bone mineral content (BMC) (p=0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	181-184
12867411-1	2003	The conversion of vitamin D into an active ligand for the vitamin D receptor requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney.	Vitamin D	18-27	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-76
21433310-1	2010	INTRODUCTION: Vitamin D is an important modulator of the autoimmune process exerting its effects through the nuclear vitamin D receptor (VDR) with transcription factor properties.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	117-135
21433310-1	2010	INTRODUCTION: Vitamin D is an important modulator of the autoimmune process exerting its effects through the nuclear vitamin D receptor (VDR) with transcription factor properties.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	137-140
21433310-2	2010	Mutations in the VDR gene may be important for vitamin D action on immunocompetent cells.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	17-20
14708943-5	2003	Moreover, 1,25-(OH)2D3 was validated as a regulator of the endogenous PDGF-A gene by the vitamin D-stimulated upregulation of PDGF-A mRNA levels in a VDR-expressing clone of JEG-3 cells.	Vitamin D	89-98	platelet derived growth factor subunit A	Homo sapiens	70-76
21433310-4	2010	The aim of this study was (a) to assess the relationship between the presence of BsmI VDR gene polymorphism and RA susceptibility, activity, and progression; (b) to compare vitamin D serum concentration in RA patients and in the control group; (c) to correlate vitamin D concentration in serum, vitamin D substitution in patients, demographic data, disease duration, RA functional and radiologic grade, RA activity, and presence of some antibodies.	Vitamin D	173-182	vitamin D receptor	Homo sapiens	86-89
19921089-1	2010	Vitamin D-dependent rickets type II (VDDR-type II) is a rare disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	97-115
14708943-5	2003	Moreover, 1,25-(OH)2D3 was validated as a regulator of the endogenous PDGF-A gene by the vitamin D-stimulated upregulation of PDGF-A mRNA levels in a VDR-expressing clone of JEG-3 cells.	Vitamin D	89-98	platelet derived growth factor subunit A	Homo sapiens	126-132
19921089-1	2010	Vitamin D-dependent rickets type II (VDDR-type II) is a rare disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	117-120
14708943-5	2003	Moreover, 1,25-(OH)2D3 was validated as a regulator of the endogenous PDGF-A gene by the vitamin D-stimulated upregulation of PDGF-A mRNA levels in a VDR-expressing clone of JEG-3 cells.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	150-153
12796488-3	2003	2MD stimulates the expression of several vitamin D-sensitive genes including 25-hydroxyvitamin D3-24 hydroxylase (Cyp24), osteopontin and receptor activator of NF kappa B ligand and suppresses osteoprotegerin at concentrations two logs lower than that for 1,25(OH)2D3.	Vitamin D	41-50	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-119
12900504-2	2003	The long-term effect of vitamin D and dietary calcium on the expression of renal VDR was examined in the nonobese diabetic mouse.	Vitamin D	24-33	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	81-84
19693091-1	2010	Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	74-92
19693091-1	2010	Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	94-97
12900504-4	2003	Vitamin D-replete mice on a 1.20% calcium diet had renal VDR levels of 165 fmol/mg protein.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	57-60
20204178-7	2010	The multiple effects of VDRAs on modulating serum Ca, parathyroid cell proliferation, and the expression of CaSR and PTH mRNA reflect the complex involvement of the vitamin D axis in regulating the mineral homeostasis system.	Vitamin D	165-174	calcium-sensing receptor	Rattus norvegicus	108-112
20871847-10	2010	In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P &lt; .0001), IFN-gamma (-38.9%, P &lt; .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P &lt; .0001), and IL-10 (-70.4%, P &lt; .0001).	Vitamin D	14-23	interleukin 10	Homo sapiens	213-218
12900504-5	2003	Calcium restriction caused renal VDR levels to decrease to &lt;30 fmol/mg protein in vitamin D-deficient mice and to approximately 80 fmol/mg protein in vitamin D-replete mice.	Vitamin D	85-94	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	33-36
12900504-6	2003	When dietary calcium was present, 50 ng of 1,25(OH)2D3 elevated the VDR levels 2- to 10-fold, depending on vitamin D status and the level of calcium.	Vitamin D	107-116	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	68-71
20003690-2	2010	The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
12900504-8	2003	1,25(OH)2D3 supplementation caused relative VDR mRNA to increase 8- to 10-fold in the vitamin D-deficient mouse when dietary calcium was available.	Vitamin D	86-95	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	44-47
20003690-8	2010	CONCLUSIONS: The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB.	Vitamin D	120-129	vitamin D receptor	Homo sapiens	32-35
12898515-1	2003	Abstract vitamin D receptor (VDR) and retinoid X receptor (RXR) heterodimerize to mediate the genomic actions of 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3), calcitriol), the biologically active form of vitamin D(3).	Vitamin D	9-18	vitamin D receptor	Homo sapiens	29-32
12898515-1	2003	Abstract vitamin D receptor (VDR) and retinoid X receptor (RXR) heterodimerize to mediate the genomic actions of 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3), calcitriol), the biologically active form of vitamin D(3).	Vitamin D	9-18	retinoid X receptor alpha	Homo sapiens	59-62
12716897-4	2003	We show that Ski can negatively regulate vitamin D-mediated transcription by directly interacting with the vitamin D receptor.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	107-125
12823989-2	2003	Vitamin D controls mineral ion homeostasis and intestinal calcium absorption, which is mediated by the nuclear vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	111-129
12823989-2	2003	Vitamin D controls mineral ion homeostasis and intestinal calcium absorption, which is mediated by the nuclear vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	131-134
19815438-1	2010	The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol).	Vitamin D	47-56	vitamin D receptor	Homo sapiens	114-132
19815438-1	2010	The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol).	Vitamin D	47-56	vitamin D receptor	Homo sapiens	77-80
12858337-1	2003	The kidney is a primary target organ of the vitamin D endocrine system, and both vitamin D-deficiency and vitamin D receptor (VDR) ablation lead to impaired renal functions.	Vitamin D	44-53	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	106-124
19815438-10	2010	However, the V26M mutation inhibited VDR binding to a consensus vitamin D response element (VDRE).	Vitamin D	64-73	vitamin D receptor	Homo sapiens	37-40
12787875-12	2003	Thus, this recombinant system harboring human CYP24 appears quite useful for predicting the metabolism and efficacy of Vitamin D analogs in human target tissues before clinical trials.	Vitamin D	119-128	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	46-51
19800081-4	2009	Vitamin D mediates its function through a single vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	49-67
19800081-4	2009	Vitamin D mediates its function through a single vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	69-72
19800081-5	2009	Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	21-24
19800081-5	2009	Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	91-94
19800081-5	2009	Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	91-94
12761332-0	2003	Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	112-130
12733718-0	2003	Two key proteins of the vitamin D endocrine system come into crystal clear focus: comparison of the X-ray structures of the nuclear receptor for 1alpha,25(OH)2 vitamin D3, the plasma vitamin D binding protein, and their ligands.	Vitamin D	24-33	GC vitamin D binding protein	Homo sapiens	183-208
19524924-1	2009	Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels.	Vitamin D	89-98	fibroblast growth factor 23	Homo sapiens	0-27
19524924-1	2009	Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels.	Vitamin D	89-98	fibroblast growth factor 23	Homo sapiens	29-34
12577303-1	2003	The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is a secosteroid whose genomic mechanism of action is similar to that of other steroid hormones and is mediated by stereospecific interaction of 1,25(OH)(2)D(3) with the vitamin D receptor (VDR) which heterodimerizes with the retinoid X receptor (RXR).	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	264-282
19647104-0	2009	Vitamin D receptor gene polymorphisms modulate the skeletal response to vitamin D supplementation in healthy girls.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	0-18
19647104-3	2009	This study investigated whether the musculo-skeletal response to Vitamin D was modulated by polymorphisms in VDR gene.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	109-112
12577303-1	2003	The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is a secosteroid whose genomic mechanism of action is similar to that of other steroid hormones and is mediated by stereospecific interaction of 1,25(OH)(2)D(3) with the vitamin D receptor (VDR) which heterodimerizes with the retinoid X receptor (RXR).	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	284-287
19647104-12	2009	CONCLUSION: VDR gene polymorphisms influence the skeletal response to vitamin D supplementation in healthy adolescent girls.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	12-15
19683963-6	2009	In particular, "hormone-like" FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined.	Vitamin D	126-135	fibroblast growth factor 23	Homo sapiens	48-53
12577303-2	2003	After interaction with the vitamin D response element (VDRE) in the promoter of target genes, transcription proceeds through the interaction of VDR with coactivators and with the transcription machinery.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	55-58
19615888-1	2009	We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	82-85
12711007-1	2003	The present study was designed to explore the possible presence and location of Vitamin D response elements (VDREs) in the human insulin receptor (hIR) gene promoter.	Vitamin D	80-89	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	147-150
14683515-0	2003	Vitamin D analogs as modulators of vitamin D receptor action.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	35-53
19895218-6	2009	The capacity of the vitamin D receptor to act as a high-affinity receptor for vitamin D and a low-affinity receptor for secondary bile acids and potentially other novel nutritional compounds suggests that the evolutionary selection to place the cathelicidin gene under control of the vitamin D receptor allows for its regulation under both endocrine and xenobiotic response systems.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	284-302
14683515-3	2003	The resulting deltanoids (vitamin D analogs) have been used in the past two decades as molecular probes to investigate structure-function relationships based on their interactions with proteins that regulate deltanoid biostability (catabolic enzymes of the vitamin D endocrine system and vitamin D binding protein) and deltanoid transduction of biological activities (nuclear and membrane receptors).	Vitamin D	26-35	GC vitamin D binding protein	Homo sapiens	288-313
19411183-9	2009	CONCLUSIONS: Our findings suggest that VDR polymorphisms may be associated with nasal carriage of S. aureus in individuals with T1D, and further contribute to the better understanding of the immunomodulatory role of vitamin D in the human host"s response and susceptibility to infection.	Vitamin D	216-225	vitamin D receptor	Homo sapiens	39-42
12424754-0	2003	Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	82-100
19713312-8	2009	Gene and protein expression of the vitamin D receptor (VDR), 25-hydroxyvitamin D-1-alpha-hydroxylase (1alphaOHase), and calbindin-D(9K) excluded renal vitamin D resistance.	Vitamin D	35-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	55-58
19419323-9	2009	Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk.	Vitamin D	162-171	klotho	Homo sapiens	33-39
12424754-1	2003	First, the general structure and function of nuclear receptors (NRs) are described briefly to help our understanding of the mechanism of action of vitamin D mediated by the vitamin D receptor (VDR), a member of the NRs.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	173-191
19666701-6	2009	The PCFT promoter region is transactivated by the vitamin D receptor (VDR) and its heterodimeric partner retinoid X receptor-alpha (RXRalpha) in the presence of vitamin D(3).	Vitamin D	50-59	vitamin D receptor	Homo sapiens	70-73
12424754-1	2003	First, the general structure and function of nuclear receptors (NRs) are described briefly to help our understanding of the mechanism of action of vitamin D mediated by the vitamin D receptor (VDR), a member of the NRs.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	193-196
12424754-2	2003	Then we discuss the structure-function relationship (SFR) of vitamin D on the basis of ligand structures and the interaction of the ligand with the VDR.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	148-151
12424754-5	2003	The SFR of ligand/VDR interaction is discussed on the basis of the crystal structure of VDR-LBD(delta 165-215), docking of various vitamin D ligands into the ligand binding pocket (LBP) of the VDR, and functional analysis of amino acids lining the LBP.	Vitamin D	131-140	vitamin D receptor	Homo sapiens	18-21
12424754-5	2003	The SFR of ligand/VDR interaction is discussed on the basis of the crystal structure of VDR-LBD(delta 165-215), docking of various vitamin D ligands into the ligand binding pocket (LBP) of the VDR, and functional analysis of amino acids lining the LBP.	Vitamin D	131-140	lipopolysaccharide binding protein	Homo sapiens	158-179
12424754-5	2003	The SFR of ligand/VDR interaction is discussed on the basis of the crystal structure of VDR-LBD(delta 165-215), docking of various vitamin D ligands into the ligand binding pocket (LBP) of the VDR, and functional analysis of amino acids lining the LBP.	Vitamin D	131-140	lipopolysaccharide binding protein	Homo sapiens	181-184
12899516-9	2003	1,25(OH)2D regulates gene expression by activating the vitamin D receptor (VDR), a transcription factor, which, in combination with the retinoid X receptor (RXR) or retinoid A receptor (RAR), binds to its vitamin D response elements (VDRE) in the promoters of genes whose expression it regulates.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	75-78
12899516-9	2003	1,25(OH)2D regulates gene expression by activating the vitamin D receptor (VDR), a transcription factor, which, in combination with the retinoid X receptor (RXR) or retinoid A receptor (RAR), binds to its vitamin D response elements (VDRE) in the promoters of genes whose expression it regulates.	Vitamin D	55-64	retinoid X receptor alpha	Homo sapiens	136-155
12899516-9	2003	1,25(OH)2D regulates gene expression by activating the vitamin D receptor (VDR), a transcription factor, which, in combination with the retinoid X receptor (RXR) or retinoid A receptor (RAR), binds to its vitamin D response elements (VDRE) in the promoters of genes whose expression it regulates.	Vitamin D	55-64	retinoid X receptor alpha	Homo sapiens	157-160
12899522-3	2003	Rapidly induced by vitamin D, CYP24 repeatedly hydroxylates the vitamin D side chain and ultimately terminates hormonal activity.	Vitamin D	19-28	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-35
12899522-3	2003	Rapidly induced by vitamin D, CYP24 repeatedly hydroxylates the vitamin D side chain and ultimately terminates hormonal activity.	Vitamin D	64-73	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-35
12899522-13	2003	Moreover, we used selective inhibitors as valuable tools to (a) elucidate regulatory mechanisms of vitamin D synthesis and metabolism, (b) determine intrinsic activities of the otherwise highly transient vitamin D metabolites and (c) model the active sites of CYP24 and CYP27B.	Vitamin D	204-213	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	260-265
12498876-1	2002	Vitamin D-resistant rickets is a genetic disease that causes severe bone underdevelopment due to mutations in the vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	114-132
12480925-1	2002	CaT1 is a highly selective calcium entry channel that has been proposed to be responsible for apical calcium entry in the vitamin D-regulated transcellular pathway of Ca(2+) absorption; however, the lack of a CaT1 antibody suitable for immunohistochemistry has prevented the direct testing of this hypothesis by the localization of CaT1 protein in the gastrointestinal tract and other tissues.	Vitamin D	122-131	transient receptor potential cation channel subfamily V member 6	Homo sapiens	0-4
12403843-1	2002	Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder most often caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	107-125
12403843-1	2002	Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder most often caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
12324918-2	2002	We hypothesized that the vitamin D receptor (VDR) genotype, which may differentiate response to endogenous or exogenous active vitamin D, has a role in the management of anemia in hemodialysis (HD) patients.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	45-48
12270218-4	2002	CYP24 is also responsible for degradation of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 which is known to be antimitotic and prodifferentiating in prostate cancer cells.	Vitamin D	56-65	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-5
12362891-6	2002	Klotho plays a critical role for the regulation of calcium and phosphorus homeostasis by negatively regulating the synthesis of active Vitamin D.	Vitamin D	135-144	klotho	Mus musculus	0-6
12144717-1	2002	The work presented here examines the possible effects of nutritional deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat.	Vitamin D	141-150	D-box binding PAR bZIP transcription factor	Rattus norvegicus	199-202
12144717-5	2002	The sensitivity of DBP to dietary protein and energy intake may constitute a novel mechanism that may help to explain the observed associations between malnutrition and the development of metabolic bone disease, through alterations to the cellular availability of vitamin D ligands to DBP.	Vitamin D	264-273	D-box binding PAR bZIP transcription factor	Rattus norvegicus	19-22
12144717-5	2002	The sensitivity of DBP to dietary protein and energy intake may constitute a novel mechanism that may help to explain the observed associations between malnutrition and the development of metabolic bone disease, through alterations to the cellular availability of vitamin D ligands to DBP.	Vitamin D	264-273	D-box binding PAR bZIP transcription factor	Rattus norvegicus	285-288
12123776-0	2002	Maternal and postnatal vitamin D ingestion influences rat aortic structure, function and elastin content.	Vitamin D	23-32	elastin	Rattus norvegicus	89-96
12123776-3	2002	Vitamin D has been shown to inhibit elastin synthesis by cultured smooth muscle cells.	Vitamin D	0-9	elastin	Rattus norvegicus	36-43
12123776-4	2002	Here we have investigated, in rats, the hypothesis that increased exposure to vitamin D during gestation and in the postnatal period alters aortic elastin content and aortic function.	Vitamin D	78-87	elastin	Rattus norvegicus	147-154
12123776-14	2002	CONCLUSION: In rats, exposure to increased amounts of vitamin D during gestation and early life results in a reduction of aortic elastin content, number of elastic lamellae in the aorta and force generation in aortic rings.	Vitamin D	54-63	elastin	Rattus norvegicus	129-136
15775406-4	2002	Klotho plays a critical role for the regulation of calcium and phosphorus homeostasis by negatively regulating the synthesis of active vitamin D.	Vitamin D	135-144	klotho	Mus musculus	0-6
12110441-11	2002	Resorption caused by IL-11 was also inhibited by both anti-mouse glycoprotein 130 (gp130) and an antibody neutralizing IL-11, but these agents had no effect on (45)Ca release caused by PTH or 1,25(OH)(2)vitamin D(3) (D(3)).	Vitamin D	203-212	interleukin 11	Mus musculus	21-26
12070083-3	2002	The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in control of differentiation, cell cycle and apoptosis of mammary cells in culture, but little is known about the physiological relevance of the vitamin D(3) endocrine system in the developing gland.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	27-30
12070083-3	2002	The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in control of differentiation, cell cycle and apoptosis of mammary cells in culture, but little is known about the physiological relevance of the vitamin D(3) endocrine system in the developing gland.	Vitamin D	60-69	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	4-25
12070083-3	2002	The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in control of differentiation, cell cycle and apoptosis of mammary cells in culture, but little is known about the physiological relevance of the vitamin D(3) endocrine system in the developing gland.	Vitamin D	60-69	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	27-30
12144199-2	2002	An "intracellular vitamin D-binding protein" functions to bind vitamin D metabolites in the cell and enhances vitamin D action.	Vitamin D	63-72	GC vitamin D binding protein	Homo sapiens	18-44
12144199-3	2002	By contrast, a "vitamin D response element-binding protein" inhibits vitamin D receptor binding to the DNA and is responsible for vitamin D resistance in New World primates.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	69-87
12039578-0	2002	Vitamin D(3): synthesis of seco C-9,11,21-trisnor-17-methyl-1 alpha, 25-dihydroxyvitamin D(3) analogues.	Vitamin D	0-9	complement C9	Homo sapiens	32-35
12051678-0	2002	Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin-binding by human vitamin D-binding protein.	Vitamin D	69-78	GC vitamin D binding protein	Homo sapiens	114-139
12188026-1	2002	The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [l,25(OH)2D3], is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and retinoic acid.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	113-131
12188026-1	2002	The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [l,25(OH)2D3], is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and retinoic acid.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	133-136
12019295-1	2002	The epithelial Ca2+ channel, ECaC1, is primarily expressed in the apical membrane of vitamin D-responsive tissues.	Vitamin D	85-94	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	29-34
12016314-4	2002	Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	14-17
19863778-0	2009	Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	75-78
11916748-5	2002	From experimental studies it was found that vitamin D metabolites directly influence muscle cell maturation and functioning through a vitamin D receptor.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	134-152
19837374-4	2009	IL-15 induced the vitamin D-dependent antimicrobial pathway and CD209, yet the cells were less phagocytic.	Vitamin D	18-27	interleukin 15	Homo sapiens	0-5
19523546-0	2009	Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	94-112
19523546-1	2009	OBJECTIVE: To study the vitamin D receptor (VDR) gene in a young girl with severe rickets and clinical features of hereditary vitamin D resistant rickets, including hypocalcemia, hypophosphatemia, partial alopecia, and elevated serum levels of 1,25-dihydroxyvitamin D.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	44-47
11963993-13	2002	This biological information in combination with the NMR properties indicates that 2a and 4a are promising probes for studying the VDR-bound A-ring conformation of vitamin D.	Vitamin D	163-172	vitamin D receptor	Homo sapiens	130-133
19581390-1	2009	The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D(3) and mediates regulation of calcium homeostasis.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
11857931-3	2002	Hereditary 1,25-dihydroxyvitamin D resistant rickets (HVDRR) known as vitamin D dependent rickets type II is a rare autosomal recessive disease that arises as a result of mutations in the gene encoding the VDR.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	55-58
19765252-4	2009	Combined cinacalcet and vitamin D can reportedly increase vitamin D receptor expression.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	58-76
11815408-5	2002	We examined the association between fasting levels of 25-OH D(3), 1,25-(OH)(2) D(3), and BsmI polymorphism of the vitamin D receptor (VDR) gene with indices of colonic epithelial cell proliferation and differentiation in a chemoprevention study, after giving vitamin D or calcium and taking rectal biopsies that were incubated with bromodeoxyuridine.	Vitamin D	114-123	vitamin D receptor	Homo sapiens	134-137
12097357-12	2002	However, the PKC isoform involved is PKCzeta, and its activity is inhibited, providing a mechanism for differential autocrine regulation of the cell and events in the matrix by these two vitamin D(3) metabolites.	Vitamin D	187-196	protein kinase C zeta	Homo sapiens	37-44
12446995-1	2002	Vitamin-D-dependent rickets type 2 results from autosomal recessive mutations of the vitamin D receptor gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	85-103
11851870-1	2002	The active vitamin D metabolite, 1,25-dihydroxyvitamin D, acting through the vitamin D receptor, regulates the expression of genes in a variety of vitamin D-responsive tissues, including the epidermis.	Vitamin D	11-20	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	77-95
11851870-1	2002	The active vitamin D metabolite, 1,25-dihydroxyvitamin D, acting through the vitamin D receptor, regulates the expression of genes in a variety of vitamin D-responsive tissues, including the epidermis.	Vitamin D	47-56	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	77-95
11751444-2	2001	The effects of vitamin D and calcium may be mediated by the vitamin D receptor (VDR), which is encoded by the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	60-78
11751444-2	2001	The effects of vitamin D and calcium may be mediated by the vitamin D receptor (VDR), which is encoded by the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	80-83
11751444-2	2001	The effects of vitamin D and calcium may be mediated by the vitamin D receptor (VDR), which is encoded by the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	110-113
11737585-9	2001	Both vitamin D compounds enhanced PT p21 expression and prevented high P-induced increases in PT TGF-alpha content.	Vitamin D	5-14	KRAS proto-oncogene, GTPase	Rattus norvegicus	37-40
11737585-9	2001	Both vitamin D compounds enhanced PT p21 expression and prevented high P-induced increases in PT TGF-alpha content.	Vitamin D	5-14	transforming growth factor alpha	Rattus norvegicus	97-106
11737585-11	2001	CONCLUSIONS: In early uremia, vitamin D suppression of high P-induced PT hyperplasia and high dietary Ca arrest of PT growth involve induction of PT p21 and prevention of increases in TGF-alpha.	Vitamin D	30-39	KRAS proto-oncogene, GTPase	Rattus norvegicus	149-152
11737585-11	2001	CONCLUSIONS: In early uremia, vitamin D suppression of high P-induced PT hyperplasia and high dietary Ca arrest of PT growth involve induction of PT p21 and prevention of increases in TGF-alpha.	Vitamin D	30-39	transforming growth factor alpha	Rattus norvegicus	184-193
11717447-0	2001	Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).	Vitamin D	77-86	cubilin	Homo sapiens	0-7
11514567-1	2001	The vitamin D receptor (VDR) is a ligand-dependent transcriptional factor that binds to vitamin D-responsive elements as a heterodimer with retinoid X receptor (RXR) to regulate target gene transcription.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
19758159-5	2009	VDR dysregulation, in turn, prevents the breakdown of the active vitamin D metabolite 1,25-hydroxyvitamin D (1,25-D) by CYP24.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	0-3
19758159-5	2009	VDR dysregulation, in turn, prevents the breakdown of the active vitamin D metabolite 1,25-hydroxyvitamin D (1,25-D) by CYP24.	Vitamin D	65-74	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	120-125
19667157-4	2009	First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 on the expression of COX-2 and 15-PGDH.	Vitamin D	47-56	carbonyl reductase 1	Homo sapiens	151-158
19371337-2	2009	Calcitriol binds to a nuclear receptor, the vitamin D receptor (VDR), and activates VDR to recruit cofactors to form a transcriptional complex that binds to vitamin D response elements in the promoter region of target genes.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	64-67
11514567-1	2001	The vitamin D receptor (VDR) is a ligand-dependent transcriptional factor that binds to vitamin D-responsive elements as a heterodimer with retinoid X receptor (RXR) to regulate target gene transcription.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	140-159
11514567-1	2001	The vitamin D receptor (VDR) is a ligand-dependent transcriptional factor that binds to vitamin D-responsive elements as a heterodimer with retinoid X receptor (RXR) to regulate target gene transcription.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	161-164
11687634-1	2001	Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25(OH)(2)D(3)] action on calcium homeostasis.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	74-77
19705334-3	2009	The binding of calcitriol to the VDR activates the recruitment of cofactors that form a transcriptional complex that binds vitamin D response elements in the promoter region of target genes.	Vitamin D	123-132	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	33-36
11369766-1	2001	Hereditary vitamin D-resistant rickets (HVDRR) is caused by heterogeneous inactivating mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	104-122
19322100-1	2009	BACKGROUND AND AIM: Next to its role as a carrier protein for vitamin D and its plasma metabolites, the primary function of vitamin D-binding protein (DBP; Gc-globulin) is to serve and to bind and neutralize extracellular monomeric actin (G-actin) released from necrotic cells, which in its long filamentous form (F-actin) triggers coagulation.	Vitamin D	62-71	GC vitamin D binding protein	Homo sapiens	124-149
11369766-1	2001	Hereditary vitamin D-resistant rickets (HVDRR) is caused by heterogeneous inactivating mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
21088715-1	2009	BACKGROUND: The VDR protein is at the centre of the vitamin D endocrine system, a complex physiological system with substantial feedback regulatory mechanisms involved in maintaining serum calcium and 1, 25 dihydroxy vitamin D3.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	16-19
19178594-3	2009	The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], has previously been reported to inhibit secretion of MMP-9 in human monocytes (MN), but its influence on the secretion and gene expression of MMP and tissue inhibitors of MMP (TIMP) in M. tuberculosis-infected cells has not previously been investigated.	Vitamin D	25-34	matrix metallopeptidase 9	Homo sapiens	145-150
11369766-4	2001	The rationale for the use of vitamin D analogs is that they bind the VDR at different amino acid residues than 1,25D(3), and their ability to modulate VDR functions differs from that of the natural hormone.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	69-72
11369766-4	2001	The rationale for the use of vitamin D analogs is that they bind the VDR at different amino acid residues than 1,25D(3), and their ability to modulate VDR functions differs from that of the natural hormone.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	151-154
19622139-1	2009	BACKGROUND: Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	130-148
11369766-6	2001	Our results reveal that vitamin D analogs partially or completely restore the responsiveness of the mutated VDR.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	108-111
19622139-1	2009	BACKGROUND: Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	150-153
11457726-5	2001	Bolus administration of gentamicin increased urinary excretion of megalin ligands (vitamin D binding protein and calcium), suggesting the competition between gentamicin and these megalin ligands in renal tubules.	Vitamin D	83-92	LDL receptor related protein 2	Rattus norvegicus	66-73
19442619-10	2009	On the other hand, although there are some biases, recent large observational studies have demonstrated that vitamin D has beneficial effects on the mortality of patients with CKD independent of serum Ca, P, and parathyroid hormone levels, likely due to its activation of the vitamin D receptor in vasculature and cardiac myocytes.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	276-294
11564619-7	2001	In multivariate linear regression models that controlled for age, education, smoking, alcohol ingestion, and vitamin D intake, the ALAD 1-1 genotype was associated with cortical bone lead levels that were 2.55 microg/g [95% confidence interval (CI) 0.05-5.05] higher than those of the variant allele carriers.	Vitamin D	109-118	aminolevulinate dehydratase	Homo sapiens	131-135
19403841-2	2009	The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
11461072-2	2001	The actions of vitamin D are mediated via the vitamin D receptor (VDR).	Vitamin D	15-24	vitamin D receptor	Homo sapiens	46-64
19219539-1	2009	INTRODUCTION: Vitamin D(3), which exerts its effect through vitamin D receptor (VDR), is known for its potent immunomodulatory activities.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	60-78
19219539-1	2009	INTRODUCTION: Vitamin D(3), which exerts its effect through vitamin D receptor (VDR), is known for its potent immunomodulatory activities.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	80-83
11461072-2	2001	The actions of vitamin D are mediated via the vitamin D receptor (VDR).	Vitamin D	15-24	vitamin D receptor	Homo sapiens	66-69
11461072-9	2001	Further investigations into the mechanisms of interactions of the VDR with other environmental and/or genetic influences to alter breast cancer risk may lead to a new understanding of the role of vitamin D in the control of cellular and developmental pathways.	Vitamin D	196-205	vitamin D receptor	Homo sapiens	66-69
11376448-4	2001	In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	175-193
18974917-3	2009	INTRODUCTION: FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D.	Vitamin D	107-116	fibroblast growth factor 23	Homo sapiens	14-19
19184092-4	2009	Vitamin D-deficient diet reverses the shortening of life span in klotho(-/-) mice.	Vitamin D	0-9	klotho	Mus musculus	65-71
19184092-12	2009	Vitamin D-deficient diet reversed the enhanced Ca(2+) entry and annexin V-binding of klotho(-/-) erythrocytes.	Vitamin D	0-9	klotho	Mus musculus	85-91
19184092-13	2009	The present observations reveal a novel function of Klotho, i.e., the at least partially vitamin D-dependent regulation of cytosolic Ca(2+) activity in and suicidal death of erythrocytes.	Vitamin D	89-98	klotho	Mus musculus	52-58
19546009-2	2009	FGF23 is produced by osteocytes in bone and acts on the kidney to inhibit 1alpha-hydroxylation of vitamin D and promote phosphorus excretion.	Vitamin D	98-107	fibroblast growth factor 23	Mus musculus	0-5
19448403-5	2009	Recent studies on estrogen and vitamin D, and their receptors (ERalpha/beta, VDR) support now the idea that non-genomic and genomic effects may integrate in a unique mode of action of nuclear receptor ligands, in which the non-genomic effects constitute signaling pathways required for the effects at the genome level.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	77-80
19483273-1	2009	FGF23; physiological action and molecular mechanism in the regulation of phosphate and vitamin D metabolism].	Vitamin D	87-96	fibroblast growth factor 23	Mus musculus	0-5
19483273-2	2009	Fibroblast growth factor (FGF) 23 is an endocrine hormone regulating the phosphate and vitamin D metabolism in the normal physiology.	Vitamin D	87-96	fibroblast growth factor 23	Mus musculus	0-33
19483273-5	2009	However, it is suggested that the phenotype of the Klotho-deficient mice results from the disturbance in the phosphate and vitamin D metabolism.	Vitamin D	123-132	klotho	Mus musculus	51-57
19255064-6	2009	Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3" UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	135-138
19255064-6	2009	Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3" UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status.	Vitamin D	202-211	vitamin D receptor	Homo sapiens	135-138
19164469-2	2009	The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] acting through the vitamin D receptor decreases prostate cancer cell growth and invasiveness.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	105-123
19244278-6	2009	BaP also increased the expression of CYP24A1 induced by a non-vitamin D VDR ligand, lithocholic acid acetate.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44
19206164-6	2009	mRNA levels of receptor activator of nuclear factor-kappaB ligand (RANKL) were increased in both populations when they were cultured with dexamethasone and vitamin D(3).	Vitamin D	156-165	TNF superfamily member 11	Homo sapiens	15-65
19206164-6	2009	mRNA levels of receptor activator of nuclear factor-kappaB ligand (RANKL) were increased in both populations when they were cultured with dexamethasone and vitamin D(3).	Vitamin D	156-165	TNF superfamily member 11	Homo sapiens	67-72
19197242-5	2009	Sustained activation of Snail1 in transgenic mice provokes deficient osteoblast differentiation, which, together with the loss of vitamin D signalling in the bone, also impairs osteoclastogenesis.	Vitamin D	130-139	snail family zinc finger 1	Mus musculus	24-30
19223536-10	2009	Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	44-47
19008093-1	2009	A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels.	Vitamin D	164-173	vitamin D receptor	Homo sapiens	184-187
19444937-1	2009	Recent studies using genetically modified mice, such as FGF23-/- and Klotho-/- mice that exhibit altered mineral homeostasis due to a high vitamin D activity showed features of premature aging that include retarded growth, osteoporosis, atherosclerosis, ectopic calcification, immunological deficiency, skin and general organ atrophy, hypogonadism and short lifespan.	Vitamin D	139-148	fibroblast growth factor 23	Mus musculus	56-61
19444937-1	2009	Recent studies using genetically modified mice, such as FGF23-/- and Klotho-/- mice that exhibit altered mineral homeostasis due to a high vitamin D activity showed features of premature aging that include retarded growth, osteoporosis, atherosclerosis, ectopic calcification, immunological deficiency, skin and general organ atrophy, hypogonadism and short lifespan.	Vitamin D	139-148	klotho	Mus musculus	69-75
19444937-4	2009	In several studies, we have described that a complete or partial lack of vitamin D action (VDR-/- mice and CYP27B1-/-) show almost similar phenotype as FGF23-/- or Klotho-/- mice.	Vitamin D	73-82	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	91-94
19444937-4	2009	In several studies, we have described that a complete or partial lack of vitamin D action (VDR-/- mice and CYP27B1-/-) show almost similar phenotype as FGF23-/- or Klotho-/- mice.	Vitamin D	73-82	klotho	Mus musculus	164-170
19290791-3	2009	Given the importance of vitamin D in bone homeostasis, common polymorphisms in the vitamin D receptor gene were the first to be investigated as possible determinants of bone mass and fracture risk.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	83-101
19183053-8	2009	The VDR binding patterns identified in this study may be used to predict functional differences among different tissues expressing different sets of coregulators, thus facilitating the goal of developing tissue- and gene-specific vitamin D response modulators.	Vitamin D	230-239	vitamin D receptor	Homo sapiens	4-7
18927213-13	2009	Our present studies provide evidence that an environmental factor, vitamin D, has only minor effects on induced immunity to the TSHR but directly affects thyroid function in mice.	Vitamin D	67-76	thyroid stimulating hormone receptor	Mus musculus	128-132
19139565-3	2009	Here we have shown that TLR9 is highly expressed by human Treg secreting the antiinflammatory cytokine IL-10 induced following stimulation of blood and tissue CD3+ T cells in the presence of 1alpha,25-dihydroxyvitamin D3 (1alpha25VitD3), the active form of Vitamin D, with or without the glucocorticoid dexamethasone.	Vitamin D	257-266	interleukin 10	Homo sapiens	103-108
19098224-4	2009	Consistent with this, VDR and SMRT are recruited to the vitamin D response element of the endogenous osteocalcin promoter in the absence of 1alpha,25-(OH)(2)D(3) in chromatin immunoprecipitation assays.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	22-25
11376448-4	2001	In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	195-198
11376448-4	2001	In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR).	Vitamin D	96-105	vitamin D receptor	Homo sapiens	175-193
11376448-4	2001	In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR).	Vitamin D	96-105	vitamin D receptor	Homo sapiens	175-193
19400699-1	2009	Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	120-138
19400699-1	2009	Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	140-143
11376448-9	2001	These results indicate that the mechanism of vitamin D resistance in NWPs is not due to a dysfunctional VDR, and is consistent with our hypothesis that vitamin D resistance in NWPs is mediated by overexpression of a VDR-independent vitamin D response element binding protein.	Vitamin D	152-161	vitamin D receptor	Homo sapiens	216-219
19400699-1	2009	Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	188-191
19400699-2	2009	Herein we review the background and evidence to date on associations between polymorphisms in VDR and selected genes in the vitamin D pathway in relation to colorectal, breast, and prostate cancer.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	94-97
11376448-9	2001	These results indicate that the mechanism of vitamin D resistance in NWPs is not due to a dysfunctional VDR, and is consistent with our hypothesis that vitamin D resistance in NWPs is mediated by overexpression of a VDR-independent vitamin D response element binding protein.	Vitamin D	152-161	vitamin D receptor	Homo sapiens	216-219
11385068-1	2001	Vitamin D receptor (VDR) null mutant mice provide a model to investigate the possible effect of vitamin D on female reproduction.	Vitamin D	96-105	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
19139017-10	2009	Reverse transcription-PCR analysis showed significant up-regulation of VDR and E-cadherin, a downstream target of vitamin D action.	Vitamin D	114-123	vitamin D receptor	Homo sapiens	71-74
19063829-6	2009	Vitamin D also modulates regulatory T-cell function and interleukin-10 production, which may increase the therapeutic response to glucocorticoids in steroid-resistant asthma.	Vitamin D	0-9	interleukin 10	Homo sapiens	56-70
19591520-2	2009	High phosphate, low calcium and vitamin D deficiency represent the classical "triad" involved into the pathogenesis of SHPT in renal insufficiency, in which downregulation of the parathyroid vitamin D receptor and calcium-sensing receptor represents a critical step.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	191-209
11385068-1	2001	Vitamin D receptor (VDR) null mutant mice provide a model to investigate the possible effect of vitamin D on female reproduction.	Vitamin D	96-105	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	20-23
11386849-1	2001	Mutations in the vitamin D receptor (VDR) cause hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disease resulting in target organ resistance to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)].	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
19309553-2	2009	In addition to its classic role in calcium homeostasis, calcitriol, the hormonal active form of vitamin D, exerts immunoregulatory effects such as modulation of Th1/Th2 cytokines.	Vitamin D	96-105	negative elongation factor complex member C/D	Homo sapiens	161-164
19309553-10	2009	These results suggest an important modulatory role of vitamin D in the Th1/Th2 immune response.	Vitamin D	54-63	negative elongation factor complex member C/D	Homo sapiens	71-74
19121771-1	2009	The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs.	Vitamin D	154-163	klotho	Homo sapiens	54-60
19121771-1	2009	The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs.	Vitamin D	154-163	fibroblast growth factor 23	Homo sapiens	65-92
19121771-1	2009	The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs.	Vitamin D	154-163	fibroblast growth factor 23	Homo sapiens	94-99
15775532-2	2001	Most of such biological actions of vitamin D are now considered to be exerted through nuclear vitamin D receptor (VDR) -mediated control of target genes.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	94-112
19121771-1	2009	The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs.	Vitamin D	309-318	klotho	Homo sapiens	54-60
19121771-1	2009	The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs.	Vitamin D	309-318	fibroblast growth factor 23	Homo sapiens	65-92
19121771-1	2009	The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs.	Vitamin D	309-318	fibroblast growth factor 23	Homo sapiens	94-99
15775532-2	2001	Most of such biological actions of vitamin D are now considered to be exerted through nuclear vitamin D receptor (VDR) -mediated control of target genes.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	114-117
11441291-6	2001	It has been shown that certain vitamin D analogs differ in their intracellular metabolism, nongenomic actions, pharmacokinetics, interaction with the vitamin D binding protein (DBP) or the vitamin D receptor (VDR).	Vitamin D	31-40	GC vitamin D binding protein	Homo sapiens	150-175
11441291-6	2001	It has been shown that certain vitamin D analogs differ in their intracellular metabolism, nongenomic actions, pharmacokinetics, interaction with the vitamin D binding protein (DBP) or the vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	189-207
11441291-6	2001	It has been shown that certain vitamin D analogs differ in their intracellular metabolism, nongenomic actions, pharmacokinetics, interaction with the vitamin D binding protein (DBP) or the vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	209-212
11441291-7	2001	Several of these new concepts are based on recent laboratory results demonstrating that VDR requires heterodimerisation with additional nuclear cofactors such as the retinoid-X receptor (RXR) for sufficient DNA-binding or are based on new findings in the metabolism of vitamin D.	Vitamin D	269-278	vitamin D receptor	Homo sapiens	88-91
20107581-1	2009	Phosphatonin fibroblast growth factor-23 (FGF-23) is involved in phosphate (P) excretion and vitamin D metabolism.	Vitamin D	93-102	fibroblast growth factor 23	Homo sapiens	42-48
11441291-7	2001	Several of these new concepts are based on recent laboratory results demonstrating that VDR requires heterodimerisation with additional nuclear cofactors such as the retinoid-X receptor (RXR) for sufficient DNA-binding or are based on new findings in the metabolism of vitamin D.	Vitamin D	269-278	retinoid X receptor alpha	Homo sapiens	166-185
11441291-7	2001	Several of these new concepts are based on recent laboratory results demonstrating that VDR requires heterodimerisation with additional nuclear cofactors such as the retinoid-X receptor (RXR) for sufficient DNA-binding or are based on new findings in the metabolism of vitamin D.	Vitamin D	269-278	retinoid X receptor alpha	Homo sapiens	187-190
19399172-5	2009	Signals emanating from CD40 are important, as CD40(-/-) DCs treated with B7-DC XAb (DC(XAb)) activated DAP12, but failed to activate NFkappaB, and were not protected from cell death upon cytokine withdrawal or treatment with Vitamin D(3).	Vitamin D	225-234	programmed cell death 1 ligand 2	Homo sapiens	73-78
11179739-10	2001	However, the ability of these agents to suppress cPLA2 activation was abrogated by co-treatment with CB1093, suggesting a role for arachidonic acid release in the caspase-independent mechanism by which vitamin D analogs prevent the protective effects of IGF-I on breast cancer cell survival.	Vitamin D	202-211	phospholipase A2 group IVA	Homo sapiens	49-54
11179741-4	2001	The findings support the hypothesis that the C-3 epimerization is an inactivation pathway of 1alpha,25(OH)(2)D(3) and its analogs in vitamin D target tissues.	Vitamin D	133-142	complement C3	Homo sapiens	45-48
11686044-10	2001	In contrast, the coexpression system with CYP24 would be applied to metabolic studies of vitamin D analogs used as drugs.	Vitamin D	89-98	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	42-47
19282648-3	2009	alpha-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney.	Vitamin D	75-84	fibroblast growth factor 23	Mus musculus	39-44
11545681-10	2001	Moreover, the increase in CaT1 mRNA expression preceded by several hours the vitamin D induction of calbindin D9K, a putative cytosolic calcium transport protein.	Vitamin D	77-86	transient receptor potential cation channel subfamily V member 6	Homo sapiens	26-30
11545681-11	2001	CONCLUSION: These observations are the first to demonstrate regulation of CaT1 expression by vitamin D and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency.	Vitamin D	93-102	transient receptor potential cation channel subfamily V member 6	Homo sapiens	74-78
11545681-11	2001	CONCLUSION: These observations are the first to demonstrate regulation of CaT1 expression by vitamin D and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency.	Vitamin D	180-189	transient receptor potential cation channel subfamily V member 6	Homo sapiens	74-78
19050268-9	2008	These results suggest that increased IL-17A in psoriatic skin increases cathelicidin through a vitamin D(3)-, Act1-, and MEK-ERK-dependent mechanism.	Vitamin D	95-104	interleukin 17A	Homo sapiens	37-43
11545681-11	2001	CONCLUSION: These observations are the first to demonstrate regulation of CaT1 expression by vitamin D and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency.	Vitamin D	180-189	transient receptor potential cation channel subfamily V member 6	Homo sapiens	232-236
19002085-3	2008	The main function of Gc-globulin is to bind vitamin D and actin, which is released into the extracellular environment upon cell and tissue lysis.	Vitamin D	44-53	GC vitamin D binding protein	Homo sapiens	21-32
11255236-9	2001	The activation was similar whether or not the vitamin D binding site of the DBP-maf was occupied.	Vitamin D	46-55	D-box binding PAR bZIP transcription factor	Rattus norvegicus	76-79
24410609-1	2008	"Vitamin D" is a generic term for a family of secosteroids, members of which bind to the vitamin D receptor.	Vitamin D	1-10	vitamin D receptor	Homo sapiens	89-107
11121228-4	2001	This phosphorylation event results in the inhibition of vitamin D signaling via VDR/hRXRalpha heterodimers.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	80-83
18597628-0	2008	Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model.	Vitamin D	0-9	TNF superfamily member 11	Homo sapiens	28-33
11121228-4	2001	This phosphorylation event results in the inhibition of vitamin D signaling via VDR/hRXRalpha heterodimers.	Vitamin D	56-65	retinoid X receptor alpha	Homo sapiens	84-93
11400211-1	2001	The vitamin D receptor (VDR) binds zinc, and the activity of vitamin D dependent genes in cells is influenced by intracellular zinc concentrations.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
11400211-8	2001	microESI-MS analyses of RXR alpha in the presence of an osteopontin vitamin D DNA response element (OP-VDRE) showed RXR alpha homodimer/OP-VDRE complexes.	Vitamin D	68-77	retinoid X receptor alpha	Homo sapiens	24-33
11400211-8	2001	microESI-MS analyses of RXR alpha in the presence of an osteopontin vitamin D DNA response element (OP-VDRE) showed RXR alpha homodimer/OP-VDRE complexes.	Vitamin D	68-77	retinoid X receptor alpha	Homo sapiens	116-125
18495457-9	2008	Similarly, genistein potentiated vitamin D"s inhibition of adipogenesis and induction of apoptosis in maturing preadipocytes by an enhanced expression of VDR (vitamin D receptor) protein.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	154-157
18495457-9	2008	Similarly, genistein potentiated vitamin D"s inhibition of adipogenesis and induction of apoptosis in maturing preadipocytes by an enhanced expression of VDR (vitamin D receptor) protein.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	159-177
10967105-4	2000	BAG1L, but not shorter non-nuclear isoforms of this protein (BAG1; BAG1M/Rap46), markedly enhanced, in a ligand-dependent manner, the ability of VDR to trans-activate reporter gene plasmids containing a vitamin D response element in transient transfection assays.	Vitamin D	203-212	vitamin D receptor	Homo sapiens	145-148
10967105-5	2000	Mutant BAG1L lacking the C-terminal Hsc70-binding domain suppressed (in a concentration-dependent fashion) VDR-mediated trans-activation of vitamin D response element-containing reporter gene plasmids, without altering levels of VDR or endogenous BAG1L protein, suggesting that it operates as a trans-dominant inhibitor of BAG1L.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	107-110
11085922-1	2000	The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)].	Vitamin D	4-13	vitamin D receptor	Homo sapiens	27-30
18729070-8	2008	FGF-23 acts to prevent widespread abnormal features by acting systemically to regulate phosphate homeostasis and vitamin D metabolism.	Vitamin D	113-122	fibroblast growth factor 23	Mus musculus	0-6
11085922-1	2000	The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)].	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	164-183
11085922-1	2000	The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)].	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	185-188
19132265-8	2008	During the summer time, vitamin D deficiency (S-25-OHD &lt; or = 25 nmol/L) affected 28% of the population, being virtually twice as much during the winter time.	Vitamin D	24-33	ribosomal protein S25	Homo sapiens	46-54
11050002-3	2000	Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR).	Vitamin D	87-96	vitamin D receptor	Homo sapiens	136-139
19132265-13	2008	By contrast, those participants taking vitamin D supplements presented higher S-25-OHD levels (summer = 69.64 nmol/L and winter = 55 nmol/L) than those not consuming it (summer = 36.83 nmol/L and winter = 25.82 nmol/L) (psummer =0.0003 and p winter &lt; 0.001).	Vitamin D	39-48	ribosomal protein S25	Homo sapiens	78-86
18694980-0	2008	Vitamin D and human health: lessons from vitamin D receptor null mice.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	41-59
11012668-12	2000	Thus, the E. coli expression system for human CYP24 appears quite useful in predicting the metabolism of vitamin D analogs used as drugs.	Vitamin D	105-114	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	46-51
18694980-5	2008	The VDR is nearly ubiquitously expressed, and almost all cells respond to 1,25-(OH)(2)D exposure; about 3% of the mouse or human genome is regulated, directly and/or indirectly, by the vitamin D endocrine system, suggesting a more widespread function.	Vitamin D	185-194	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	4-7
19035286-4	2008	Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	178-196
19035286-4	2008	Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	198-201
11006359-13	2000	To our knowledge, this is the first report of PCB-induced effects on vitamin D(3) metabolites.	Vitamin D	69-78	pyruvate carboxylase	Rattus norvegicus	46-49
18442315-1	2008	Fibroblast growth factor (FGF)23 is proposed to play a physiological role in the regulation of phosphate and vitamin D metabolism; deranged circulatory levels of FGF23 cause several diseases with abnormal mineral metabolism.	Vitamin D	109-118	fibroblast growth factor 23	Mus musculus	0-32
18442315-7	2008	Thus, this study using neutralizing antibodies confirms that FGF23 is a physiological regulator of phosphate and vitamin D metabolism.	Vitamin D	113-122	fibroblast growth factor 23	Mus musculus	61-66
18602086-7	2008	Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs).	Vitamin D	186-195	vitamin D receptor	Homo sapiens	61-64
18602086-7	2008	Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs).	Vitamin D	186-195	major histocompatibility complex, class II, DR beta 4	Homo sapiens	87-90
18602086-7	2008	Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs).	Vitamin D	186-195	ADAM metallopeptidase domain 23	Homo sapiens	95-99
18602086-7	2008	Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs).	Vitamin D	186-195	major histocompatibility complex, class II, DR beta 4	Homo sapiens	105-108
10825392-1	2000	The vitamin D receptor (VDR) is the nuclear receptor for 1, 25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] that acts as a ligand-dependent transcription factor via combined contact with coactivator proteins (steroid receptor coactivator-1, transcriptional intermediary factor 2, and receptor associated coactivator 3) and specific DNA binding sites [vitamin D response elements (VDREs)].	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
10835626-4	2000	5) mapped to one peak, and CYP24 (encoding vitamin D 24 hydroxylase), whose overexpression is likely to lead to abrogation of growth control mediated by vitamin D, mapped to the other.	Vitamin D	43-52	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	27-32
18678710-0	2008	FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis.	Vitamin D	62-71	fibroblast growth factor 23	Mus musculus	0-6
18678710-0	2008	FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis.	Vitamin D	62-71	klotho	Mus musculus	7-13
18678710-3	2008	We show that the signal transduction pathways initiated by FGF-23-Klotho prevent tissue atrophy by stimulating proliferation and preventing apoptosis caused by excessive systemic vitamin D.	Vitamin D	179-188	fibroblast growth factor 23	Mus musculus	59-65
18678710-3	2008	We show that the signal transduction pathways initiated by FGF-23-Klotho prevent tissue atrophy by stimulating proliferation and preventing apoptosis caused by excessive systemic vitamin D.	Vitamin D	179-188	klotho	Mus musculus	66-72
18678710-4	2008	Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity.	Vitamin D	31-40	fibroblast growth factor 23	Mus musculus	88-94
10772887-7	2000	Vitamin D analogs effectively reduce DC function via VDR-dependent pathways.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	53-56
18678710-4	2008	Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity.	Vitamin D	31-40	klotho	Mus musculus	98-104
18678710-4	2008	Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity.	Vitamin D	191-200	fibroblast growth factor 23	Mus musculus	88-94
18678710-4	2008	Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity.	Vitamin D	191-200	klotho	Mus musculus	98-104
10698207-2	2000	Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	9-12
18689389-4	2008	Over the past several decades, the biological sphere of influence of vitamin D(3), as defined by the tissue distribution of the VDR, has broadened at least 9-fold from the target organs required for calcium homeostasis (intestine, bone, kidney, and parathyroid).	Vitamin D	69-78	vitamin D receptor	Homo sapiens	128-131
18689389-7	2008	This article identifies the fundamentals of the vitamin D endocrine system, including its potential for contributions to good health in 5 physiologic arenas in which investigators have clearly documented new biological actions of 1alpha,25(OH)(2)D(3) through the VDR.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	263-266
18559986-9	2008	These data suggest that the regulation of extracellular matrix mineralization by DMP1 is coupled to renal phosphate handling and vitamin D metabolism through a DMP1-dependent regulation of FGF23 production by osteocytes.	Vitamin D	129-138	fibroblast growth factor 23	Mus musculus	189-194
10698207-2	2000	Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	111-114
10698207-2	2000	Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription.	Vitamin D	82-91	retinoid X receptor alpha	Homo sapiens	73-76
18660672-3	2008	FGF23 is a bone-derived hormone that regulates phosphate and vitamin D metabolism.	Vitamin D	61-70	fibroblast growth factor 23	Mus musculus	0-5
10698207-2	2000	Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	111-114
18660672-9	2008	Further investigations on endocrine axes mediated by the Klotho family and FGF19 subfamily members are expected to provide new insights into the molecular mechanisms by which the endocrine fibroblast growth factors regulate bile acid, energy, and phosphate/vitamin D metabolism.	Vitamin D	257-266	klotho	Mus musculus	57-63
10698207-2	2000	Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription.	Vitamin D	213-222	vitamin D receptor	Homo sapiens	9-12
18348143-5	2008	Mechanistic studies using chromatin immunoprecipitation (ChIP) assay revealed that a direct repeat-3 (DR3) vitamin D response element located in the first intron of the G6PD genome can be bound by liganded vitamin D receptor, thereby regulating G6PD gene expression.	Vitamin D	107-116	glucose-6-phosphate dehydrogenase	Homo sapiens	169-173
10698207-7	2000	Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	42-45
18348143-5	2008	Mechanistic studies using chromatin immunoprecipitation (ChIP) assay revealed that a direct repeat-3 (DR3) vitamin D response element located in the first intron of the G6PD genome can be bound by liganded vitamin D receptor, thereby regulating G6PD gene expression.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	206-224
10698207-7	2000	Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	73-76
18348143-5	2008	Mechanistic studies using chromatin immunoprecipitation (ChIP) assay revealed that a direct repeat-3 (DR3) vitamin D response element located in the first intron of the G6PD genome can be bound by liganded vitamin D receptor, thereby regulating G6PD gene expression.	Vitamin D	107-116	glucose-6-phosphate dehydrogenase	Homo sapiens	245-249
10698207-7	2000	Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation.	Vitamin D	98-107	retinoid X receptor alpha	Homo sapiens	77-80
11595822-1	2000	Vitamin D and retinoic acid (RA) receptors (VDRs and RARs, respectively), bind as heterodimers with the retinoid X receptor (RXR) to hormone response elements (HREs) in target genes.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	104-123
18501591-13	2008	In contrast, (23S)-25-deoxy-1alpha-hydroxyvitamin D(3)-26,23-lactone, which only blocks human VDR, these vitamin D antagonists can block VDR in human cells and rodent cells.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	137-140
18502116-7	2008	Gene expression of vitamin D target genes, epithelial Ca(2+) channel 1 (ecac1) and Calbindin-D28k (cabp-d28k), involved in renal calcium transport were decreased.	Vitamin D	19-28	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	43-70
11595822-1	2000	Vitamin D and retinoic acid (RA) receptors (VDRs and RARs, respectively), bind as heterodimers with the retinoid X receptor (RXR) to hormone response elements (HREs) in target genes.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	125-128
18502116-7	2008	Gene expression of vitamin D target genes, epithelial Ca(2+) channel 1 (ecac1) and Calbindin-D28k (cabp-d28k), involved in renal calcium transport were decreased.	Vitamin D	19-28	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	72-77
11595822-3	2000	However, VDR/RXR heterodimers bind in a transcriptionally unproductive manner and without a defined polarity on certain RA response elements, and under these circumstances vitamin D inhibits the response to RA.	Vitamin D	172-181	vitamin D receptor	Homo sapiens	9-12
11595822-3	2000	However, VDR/RXR heterodimers bind in a transcriptionally unproductive manner and without a defined polarity on certain RA response elements, and under these circumstances vitamin D inhibits the response to RA.	Vitamin D	172-181	retinoid X receptor alpha	Homo sapiens	13-16
10587460-1	1999	The vitamin D receptor (VDR) binds 1,25-dihydroxyvitamin D(3) and mediates its actions on gene transcription by heterodimerizing with retinoid X receptors (RXRs) on direct repeat (DR+3) vitamin D responsive elements (VDREs) located in target genes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
18256372-2	2008	Furthermore, vitamin D and phosphate stimulate FGF23 production, the pathogenic factor causing XLH.	Vitamin D	13-22	fibroblast growth factor 23	Homo sapiens	47-52
10523637-0	1999	Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.	Vitamin D	83-92	Y box binding protein 1	Rattus norvegicus	9-13
18334925-1	2008	INTRODUCTION: Vitamin D-binding protein (also called DBP or Gc-globulin) is recognized as a multifunctional protein involved in the action scavenger system, the transport of vitamin D sterols, and the modulation of immune and inflammatory responses.	Vitamin D	174-183	GC vitamin D binding protein	Homo sapiens	14-39
10523637-7	1999	Strikingly, mutation of the three Cbfa sites leads to abrogation of responsiveness to vitamin D.	Vitamin D	86-95	Y box binding protein 1	Rattus norvegicus	34-38
18565252-13	2008	Treatment of L OA osteoblasts with osteotropic factors revealed that the OPG/RANKL mRNA expression ratio was significantly reduced by vitamin D(3) and significantly increased by TNF-alpha, PTH and PGE(2), while IL-1Beta demonstrated no effect.	Vitamin D	134-143	TNF superfamily member 11	Homo sapiens	77-82
10523637-9	1999	Significantly, related to these losses in transcriptional activity, mutation of the three Cbfa sites results in altered chromatin structure as reflected by loss of DNase I-hypersensitive sites at the vitamin D response element and over the proximal tissue-specific basal promoter.	Vitamin D	200-209	Y box binding protein 1	Rattus norvegicus	90-94
10499529-6	1999	However, further investigations will be needed to discuss physiologically the meaning of insulinotropic effects of vitamin D through mVDR.	Vitamin D	115-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	133-137
17878606-4	2008	In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	13-18
10540876-1	1999	Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	102-120
10540876-1	1999	Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	122-125
18266602-4	2008	These data provide preliminary evidence of associations of VDR polymorphisms with the risk of ALRI (predominantly viral bronchiolitis) in young children, consistent with a potential role of vitamin D in the immune response to respiratory tract infection.	Vitamin D	190-199	vitamin D receptor	Homo sapiens	59-62
10540876-2	1999	Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	135-138
10540876-2	1999	Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	175-178
10540876-6	1999	Furthermore, VDR recruit several coactivators to achieve vitamin D-induced transactivation.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	13-16
18079052-1	2008	The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
10540876-7	1999	Selective coactivator interaction with VDR may specify the array of biological actions of vitamin D.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	39-42
10540886-1	1999	Recently, It has become clear that the mutant gene in X-linked hypophosphatemic rickets, vitamin D dependent rickets type I, and vitamin D dependent rickets type II were identified and they were caused by the disorder in the activation of vitamin D and the intracellular defect in vitamin D receptor.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	281-299
18211694-13	2008	The latter, together with findings demonstrating specific effects of calcitriol acting through the VDR and the cAMP/PKA signaling pathway upon hCG expression and secretion, indicate that there is a functional vitamin D endocrine system in the placenta, and recognize calcitriol as an autocrine regulator of hCG.	Vitamin D	209-218	vitamin D receptor	Homo sapiens	99-102
18213391-6	2008	We conclude that VDR is a TCF/Lef-independent transcriptional effector of the Wnt pathway and that vitamin D analogues have therapeutic potential in tumors with inappropriate activation of Wnt signalling.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	17-20
10540886-1	1999	Recently, It has become clear that the mutant gene in X-linked hypophosphatemic rickets, vitamin D dependent rickets type I, and vitamin D dependent rickets type II were identified and they were caused by the disorder in the activation of vitamin D and the intracellular defect in vitamin D receptor.	Vitamin D	129-138	vitamin D receptor	Homo sapiens	281-299
10444570-3	1999	The activated vitamin D receptor (VDR) dimerizes with another nuclear receptor, the retinoid X receptor (RXR), and the heterodimer binds to specific DNA motifs (vitamin D response elements, VDREs) in the promoter region of target genes.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	34-37
18175872-4	2008	It has been reported that direct vitamin D injection into parathyroid gland (PTG) efficiently decreased PTH level without significant changes of Ca level in dialysis patients as well as in uremic animals, possibly through up-regulation of CaSR and vitamin D receptor and decrease of cell number in PTC.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	248-266
10385427-0	1999	Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas.	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	82-87
10385427-8	1999	These data are consistent with the emerging hypothesis that vitamin D through its active form does not directly turn off CYP1alpha mRNA production but, rather, strongly stimulates CYP24, thereby masking CYP1alpha activity.	Vitamin D	60-69	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	180-185
18246496-2	2008	The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	175-193
18246496-2	2008	The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	195-198
10342883-9	1999	In agreement with this hypothesis, overexpression of E1A, which can act as a RARbeta2 promoter-specific coactivator, significantly reversed repression by vitamin D.	Vitamin D	154-163	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	53-56
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	197-215
18254883-2	2008	Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte.	Vitamin D	115-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	217-220
10223184-3	1999	We determined the expression, DNA binding and transactivation activity of vitamin D3 receptor (VDR) in HBL100 and a vitamin D-sensitive ZR75-1 breast cancer cell line.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	95-98
18290716-1	2007	Tissue availability of the active vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] is dependent on expression of the activating enzyme 1alpha-hydroxylase (CYP27b1) and its catabolic counterpart 24-hydroxylase (CYP24).	Vitamin D	34-43	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	222-227
18290716-9	2007	In either case, the 1,25(OH)(2)D ligand is required for the VDR to heterodimerize with the retinoid x receptor and compete away the dominant-negative acting, heterogeneous nuclear ribonucleoprotein (hnRNP)-related, vitamin D response element-binding proteins that inhibit hormone-directed transactivation of genes.	Vitamin D	215-224	vitamin D receptor	Homo sapiens	60-63
18290729-1	2007	Since the discovery of the vitamin D receptor (VDR) in mammary cells, the role of the vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	47-50
10234571-2	1999	Several analogs were examined for their effects on DNA binding of the vitamin D receptor (VDR) homodimer complex with the murine osteopontin vitamin D response element.	Vitamin D	70-79	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	90-93
10234571-11	1999	The results indicate that VDR homodimers are targets of vitamin D analogs with differential effects on C-terminal protein conformation that may partially explain the varied biological responses of these compounds.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	26-29
10418998-1	1999	Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	57-75
17557889-3	2007	Moreover, recent evidence strongly suggests that vitamin D supplementation may be therapeutically beneficial, particularly for Th1-mediated autoimmune disorders.	Vitamin D	49-58	negative elongation factor complex member C/D	Homo sapiens	127-130
10418998-1	1999	Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	77-80
17644135-4	2007	Vitamin D receptor expression was examined by Western immunoblot analysis after incubating the cells with 250 to 800 nM vitamin D, 10 to 70 nM testosterone, 2 nM calcium or a combination of the 3 products.	Vitamin D	120-129	vitamin D receptor	Homo sapiens	0-18
10418998-2	1999	The transactivation function of VDR is activated by binding 1alpha,25-dihydroxyvitamin D3[1alpha,25(OH)2D3], an active form of vitamin D.	Vitamin D	79-88	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	32-35
17644135-9	2007	Sequential concentrations of vitamin D increased vitamin D receptor expression intensity.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	49-67
10418998-4	1999	Deficiency of vitamin D and mutations in the genes like VDR (type II genetic rickets) are known to cause rickets like lowered serum calcium, alopecia and impaired bone formation.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	56-59
17644135-10	2007	Simultaneous addition of vitamin D and testosterone decreased the vitamin D receptor signal, as did testosterone alone.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	66-84
17644135-11	2007	Delayed administration of vitamin D 5 hours after testosterone showed the return of vitamin D receptor expression.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	84-102
10418998-5	1999	However, the molecular basis of vitamin D VDR system in the vitamin D action in intact animals remained to be established.	Vitamin D	32-41	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	42-45
10418998-5	1999	However, the molecular basis of vitamin D VDR system in the vitamin D action in intact animals remained to be established.	Vitamin D	60-69	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	42-45
10418998-9	1999	These results demonstrated indispensability of vitamin D-VDR system in mineral and bone metabolism only in post-weaning life.	Vitamin D	47-56	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	57-60
10052935-9	1999	Removal of two putative direct repeat DNA fragments in this region abolished VDR-RXR alpha-vitamin D response element complex formation.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	77-80
10052935-9	1999	Removal of two putative direct repeat DNA fragments in this region abolished VDR-RXR alpha-vitamin D response element complex formation.	Vitamin D	91-100	retinoid X receptor alpha	Homo sapiens	81-90
10321413-5	1999	As with vitamin D, the biologic action of paricalcitol is mediated through activation of the vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D receptor	Homo sapiens	93-111
10052463-1	1999	The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor"s ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	88-91
10052463-1	1999	The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor"s ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex.	Vitamin D	37-46	retinoid X receptor alpha	Homo sapiens	152-155
9881643-2	1998	The VDR, bound to 1alpha,25(OH)2D3, forms a heterodimer with a nuclear accessory factor, retinoid X receptor (RXR), and the complex subsequently binds to specific nucleotide sequences or a vitamin D-responsive element (VDRE) to induce gene transcriptions.	Vitamin D	189-198	vitamin D receptor	Homo sapiens	4-7
9881643-2	1998	The VDR, bound to 1alpha,25(OH)2D3, forms a heterodimer with a nuclear accessory factor, retinoid X receptor (RXR), and the complex subsequently binds to specific nucleotide sequences or a vitamin D-responsive element (VDRE) to induce gene transcriptions.	Vitamin D	189-198	retinoid X receptor alpha	Homo sapiens	89-108
9881643-2	1998	The VDR, bound to 1alpha,25(OH)2D3, forms a heterodimer with a nuclear accessory factor, retinoid X receptor (RXR), and the complex subsequently binds to specific nucleotide sequences or a vitamin D-responsive element (VDRE) to induce gene transcriptions.	Vitamin D	189-198	retinoid X receptor alpha	Homo sapiens	110-113
9797477-9	1998	The ability of the two VDR forms to transactivate target genes was investigated using three different vitamin D responsive luciferase reporter constructs: 24-hydroxylase, osteocalcin, and osteopontin.	Vitamin D	102-111	vitamin D receptor	Homo sapiens	23-26
17286279-7	2007	These data conclusively demonstrate that VDR mediates the anti-proliferative and pro-apoptotic effects of vitamin D metabolites and analogs, but that the potency of a vitamin D compound to induce the VDR target gene CYP24 does not accurately predict its potency in mediating growth regulation.	Vitamin D	106-115	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	41-44
17286279-7	2007	These data conclusively demonstrate that VDR mediates the anti-proliferative and pro-apoptotic effects of vitamin D metabolites and analogs, but that the potency of a vitamin D compound to induce the VDR target gene CYP24 does not accurately predict its potency in mediating growth regulation.	Vitamin D	167-176	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	200-203
17286279-7	2007	These data conclusively demonstrate that VDR mediates the anti-proliferative and pro-apoptotic effects of vitamin D metabolites and analogs, but that the potency of a vitamin D compound to induce the VDR target gene CYP24 does not accurately predict its potency in mediating growth regulation.	Vitamin D	167-176	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	216-221
17342072-1	2007	BACKGROUND: Vitamin D-binding protein (DBP) gene is well known for its function on glucose and vitamin D metabolism in human populations.	Vitamin D	95-104	GC vitamin D binding protein	Homo sapiens	12-37
17982392-5	2007	Recently, fibroblast growth factor 23 (FGF23) has emerged as an important humoral factor regulating phosphate and vitamin D homeostasis.	Vitamin D	114-123	fibroblast growth factor 23	Homo sapiens	10-37
17982392-5	2007	Recently, fibroblast growth factor 23 (FGF23) has emerged as an important humoral factor regulating phosphate and vitamin D homeostasis.	Vitamin D	114-123	fibroblast growth factor 23	Homo sapiens	39-44
17635819-1	2007	The discovery of fibroblast growth factor 23 (FGF23), a novel bone-derived hormone that inhibits phosphate reabsorption and calcitriol production by the kidney, has uncovered primary regulatory pathways and new systems biology governing bone mineralization, vitamin D metabolism, parathyroid gland function and renal phosphate handling.	Vitamin D	258-267	fibroblast growth factor 23	Homo sapiens	17-44
17635819-1	2007	The discovery of fibroblast growth factor 23 (FGF23), a novel bone-derived hormone that inhibits phosphate reabsorption and calcitriol production by the kidney, has uncovered primary regulatory pathways and new systems biology governing bone mineralization, vitamin D metabolism, parathyroid gland function and renal phosphate handling.	Vitamin D	258-267	fibroblast growth factor 23	Homo sapiens	46-51
9808140-1	1998	Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	99-117
17487855-11	2007	VDR expression may constitute an important prerequisite for using vitamin D and/or its analogs in the treatment of CCA.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	0-3
9808140-1	1998	Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	119-122
9751523-3	1998	VDR-ablated mice and control littermates were fed a diet that has been shown to prevent secondary hyperparathyroidism in vitamin D-deficient rats.	Vitamin D	121-130	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
17352646-5	2007	It is caused by mesenchymal tumors that produce the phosphate and vitamin D-regulating hormone, fibroblast growth factor (FGF)-23.	Vitamin D	66-75	fibroblast growth factor 23	Homo sapiens	96-129
9761785-12	1998	In contrast, a VDR genotype, which has been associated with decreased serum levels of the active hormonal form of vitamin D and increased risk for certain cancers, seemed to be related to severity of CAD (P=0.025).	Vitamin D	114-123	vitamin D receptor	Homo sapiens	15-18
17556530-9	2007	Paradoxically, mutations in the VDR ligand-dependent transcriptional activation function-2 that abrogate vitD3-dependent stimulation through classical vitamin D response elements, do not reduce vitD3-mediated LTR transactivation.	Vitamin D	151-160	vitamin D receptor	Homo sapiens	32-35
17353153-2	2007	Recent studies have identified that fibroblast growth factor 23 (Fgf-23) null mice and klotho hypomorphs could generate multiple premature aging-like features, including shortened lifespan, infertility, kyphosis, atherosclerosis, extensive soft tissue calcifications, skin atrophy, muscle wasting, T cell dysregulation, pulmonary emphysema, osteoporosis/osteopenia, abnormal mineral ion metabolism, and impaired vitamin-D homeostasis.	Vitamin D	412-421	fibroblast growth factor 23	Mus musculus	36-63
9751364-1	1998	PURPOSE: Reports in the osteoporosis literature demonstrating the increased activity of specific alleles of the vitamin D receptor and epidemiological data linking vitamin D levels with prostate cancer have stimulated research into possible associations between vitamin D receptor genotype and the development of prostate cancer.	Vitamin D	112-121	vitamin D receptor	Homo sapiens	262-280
17353153-2	2007	Recent studies have identified that fibroblast growth factor 23 (Fgf-23) null mice and klotho hypomorphs could generate multiple premature aging-like features, including shortened lifespan, infertility, kyphosis, atherosclerosis, extensive soft tissue calcifications, skin atrophy, muscle wasting, T cell dysregulation, pulmonary emphysema, osteoporosis/osteopenia, abnormal mineral ion metabolism, and impaired vitamin-D homeostasis.	Vitamin D	412-421	fibroblast growth factor 23	Mus musculus	65-71
17353153-2	2007	Recent studies have identified that fibroblast growth factor 23 (Fgf-23) null mice and klotho hypomorphs could generate multiple premature aging-like features, including shortened lifespan, infertility, kyphosis, atherosclerosis, extensive soft tissue calcifications, skin atrophy, muscle wasting, T cell dysregulation, pulmonary emphysema, osteoporosis/osteopenia, abnormal mineral ion metabolism, and impaired vitamin-D homeostasis.	Vitamin D	412-421	klotho	Mus musculus	87-93
9749832-10	1998	These results indicate that a critical nucleotide sequence is necessary for the binding to the VDR and for mediating the vitamin D effect, and suggest the different regulation between the rat and human 24-hydroxylase gene.	Vitamin D	121-130	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	202-216
9731705-3	1998	Previous studies indicated that when MCF-7 cells are transfected with the rat CaBP9k VDRE ligated to the thymidine kinase promoter and treated with both 1,25-(OH)2D3 and T3 there is an enhancement of the response observed with 1,25-(OH)2D3 alone, suggesting direct cross-talk between thyroid hormone and the vitamin D endocrine system and activation via the formation of vitamin D receptor (VDR)-thyroid hormone receptor (TR) heterodimers.	Vitamin D	308-317	vitamin D receptor	Homo sapiens	85-88
17408240-3	2007	The results obtained from this screening of our synthetic vitamin D analogues suggest that the CoA-recruiting activities play an important role in determining the biological activity of various vitamin D analogues and explain the discrepancies between the VDR binding affinity and their biological activity.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	256-259
9731706-8	1998	In a similar fashion, v-erbA was found to repress a subset of vitamin D response elements.	Vitamin D	62-71	thyroid hormone receptor alpha	Homo sapiens	24-28
17408240-3	2007	The results obtained from this screening of our synthetic vitamin D analogues suggest that the CoA-recruiting activities play an important role in determining the biological activity of various vitamin D analogues and explain the discrepancies between the VDR binding affinity and their biological activity.	Vitamin D	194-203	vitamin D receptor	Homo sapiens	256-259
18406281-2	1998	The vitamin D endocrine system plays a fundamental role in the regulation of Ca(2+) homeostasis, and mutations affecting genes implicated in vitamin D metabolism or vitamin D receptor (VDR) functions are responsible for severe alterations in skeletal growth.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	165-183
17470992-4	2007	FGF23 is associated with vitamin D metabolism as well as tubular phosphate excretion.	Vitamin D	25-34	fibroblast growth factor 23	Homo sapiens	0-5
17470992-5	2007	Moreover, recent study using animal models revealed the task of klotho protein, which gene functions as an aging-suppressor gene, for the regulation of FGF23 signaling, Ca(2+) absorption and vitamin D modulation in the kidney.	Vitamin D	191-200	klotho	Homo sapiens	64-70
17470992-5	2007	Moreover, recent study using animal models revealed the task of klotho protein, which gene functions as an aging-suppressor gene, for the regulation of FGF23 signaling, Ca(2+) absorption and vitamin D modulation in the kidney.	Vitamin D	191-200	fibroblast growth factor 23	Homo sapiens	152-157
18406281-2	1998	The vitamin D endocrine system plays a fundamental role in the regulation of Ca(2+) homeostasis, and mutations affecting genes implicated in vitamin D metabolism or vitamin D receptor (VDR) functions are responsible for severe alterations in skeletal growth.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	185-188
9691832-1	1998	The active metabolite of vitamin D, 1,25 (OH)2D3, exerts its cell cycle regulating effects via binding to VDR (Vitamin D Receptor).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	106-109
17254542-9	2007	These studies suggest that the LxxLL motif can interact directly with the VDR and that this interaction is regulated by chemically diverse vitamin D ligands.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	74-77
17302875-10	2007	CONCLUSION: The results support the idea that a non-1alpha-hydroxylated vitamin D analogue may elicit vitamin D receptor (VDR) effects in 1alpha-hydroxylase expressing parathyroid tumour cells.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	102-120
17302875-10	2007	CONCLUSION: The results support the idea that a non-1alpha-hydroxylated vitamin D analogue may elicit vitamin D receptor (VDR) effects in 1alpha-hydroxylase expressing parathyroid tumour cells.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	122-125
9691832-1	1998	The active metabolite of vitamin D, 1,25 (OH)2D3, exerts its cell cycle regulating effects via binding to VDR (Vitamin D Receptor).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	111-129
9691832-3	1998	The VDR-RXR heterodimer binds to promoter regions of cell cycle regulating genes through a vitamin D response element (VDRE).	Vitamin D	91-100	vitamin D receptor	Homo sapiens	4-7
9691832-3	1998	The VDR-RXR heterodimer binds to promoter regions of cell cycle regulating genes through a vitamin D response element (VDRE).	Vitamin D	91-100	retinoid X receptor alpha	Homo sapiens	8-11
9639512-5	1998	A heterodimer consisting of the retinoid X receptor and the VDR binds to vitamin D responsive elements on genes regulated by vitamin D.	Vitamin D	73-82	retinoid X receptor alpha	Homo sapiens	32-51
17110426-1	2007	We tested the hypothesis that low vitamin D receptor (VDR) level causes intestinal vitamin D resistance and intestinal calcium (Ca) malabsorption.	Vitamin D	34-43	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	54-57
17204417-0	2007	Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal Vitamin D metabolism.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	46-49
9639512-5	1998	A heterodimer consisting of the retinoid X receptor and the VDR binds to vitamin D responsive elements on genes regulated by vitamin D.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	60-63
9639512-5	1998	A heterodimer consisting of the retinoid X receptor and the VDR binds to vitamin D responsive elements on genes regulated by vitamin D.	Vitamin D	125-134	retinoid X receptor alpha	Homo sapiens	32-51
17234401-0	2007	Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	77-95
17254771-0	2007	Novel insights in the immune function of the vitamin D system: synergism with interferon-beta.	Vitamin D	45-54	interferon beta 1, fibroblast	Mus musculus	78-93
17254776-1	2007	Since the discovery of the Vitamin D receptor (VDR) in mammary cells, the role of the Vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	47-50
9639512-5	1998	A heterodimer consisting of the retinoid X receptor and the VDR binds to vitamin D responsive elements on genes regulated by vitamin D.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	60-63
9556566-0	1998	A negative vitamin D response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	105-123
17280828-8	2007	In addition, calcitriol induced the Vitamin D metabolizing enzyme, 24-hydroxylase (cyp24) mRNA and enzyme activity similarly in naive and VDI cells as measured by RT-PCR and HPLC, respectively.	Vitamin D	36-45	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	83-88
9556566-8	1998	These results indicate that nVDREhPTHrP interacts with Ku antigen in addition to VDR to mediate gene suppression by vitamin D.	Vitamin D	116-125	vitamin D receptor	Homo sapiens	29-32
17368177-0	2007	New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	35-38
9579411-8	1998	Since VDR mRNA expression has been already reported in human brain tumors, our data imply that the identification of VDR expression could become a prerequisite in any strategy of glioma treatment with vitamin D analogs.	Vitamin D	201-210	vitamin D receptor	Homo sapiens	117-120
17368177-1	2007	Recently, we have developed a Vitamin D sterol (VDS)-VDR conformational ensemble model.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	53-56
9584330-6	1998	Since only the vitamin D compounds which possess hydroxyl groups both in the position 1 alpha and in the side chain, bind to the vitamin D receptor, we suggest that a local metabolism of MC 1582 and 1 alpha(OH)D3 takes place in the skin to the active, side-chain-hydroxylated species, probably to KH 1060 and 1 alpha,25(OH)2D3.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	129-147
17192268-3	2007	A CEACAM1 membrane model based on vitamin D-binding protein that predicts an interaction of Phe(454) at subdomain 3 of actin was supported by inhibition of binding of actin to vitamin D-binding protein by the cytoplasmic domain peptide.	Vitamin D	34-43	CEA cell adhesion molecule 1	Homo sapiens	2-9
17192268-3	2007	A CEACAM1 membrane model based on vitamin D-binding protein that predicts an interaction of Phe(454) at subdomain 3 of actin was supported by inhibition of binding of actin to vitamin D-binding protein by the cytoplasmic domain peptide.	Vitamin D	176-185	CEA cell adhesion molecule 1	Homo sapiens	2-9
16950800-10	2007	This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC.	Vitamin D	121-130	methylenetetrahydrofolate reductase	Homo sapiens	60-65
9492012-0	1998	Analysis of vitamin D-dependent calcium-binding protein messenger ribonucleic acid expression in mice lacking the vitamin D receptor.	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	114-132
16950800-10	2007	This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	70-73
9564171-1	1998	The vitamin D hormone, 1,25-dihydroxyvitamin D3, functions by way of a nuclear receptor (vitamin D receptor [VDR]) in a manner analogous to the other members of the steroid-thyroid hormone superfamily.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	89-107
16990805-1	2007	Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR).	Vitamin D	58-67	vitamin D receptor	Homo sapiens	227-245
16990805-1	2007	Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR).	Vitamin D	58-67	vitamin D receptor	Homo sapiens	247-250
17046242-7	2007	These Vitamin D analogs did not change the expression of Vitamin D receptor (VDR) up to 10nM, but stimulated CYP24A1 expression in a dose-dependent manner with the potency in the order of 1,25-dihydroxyvitamin D(3)&gt;1,25-dihydroxyvitamin D(2)=19-nor-1,25-dihydroxyvitamin D(2).	Vitamin D	6-15	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	109-116
9564171-1	1998	The vitamin D hormone, 1,25-dihydroxyvitamin D3, functions by way of a nuclear receptor (vitamin D receptor [VDR]) in a manner analogous to the other members of the steroid-thyroid hormone superfamily.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	109-112
9564171-8	1998	As VDR has been detected in cells not previously thought to be target organs, scientists continue to discover new functions of vitamin D.	Vitamin D	127-136	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	3-6
11542408-0	1998	Biological dosimetry to determine the UV radiation climate inside the MIR station and its role in vitamin D biosynthesis.	Vitamin D	98-107	membrane associated ring-CH-type finger 8	Homo sapiens	70-73
17237289-4	2007	This study examines the potential synergistic effect of SPARC and vitamin D, which up-regulates VDR, in enhancing chemotherapy response in colorectal cancer.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	96-99
9792954-14	1998	These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene.	Vitamin D	220-229	vitamin D receptor	Homo sapiens	142-145
17507873-1	2007	Isoflavonoids exert a regulatory function on the expression of cytochrome P450 enzymes and also up-regulate the vitamin D(3) receptor (VDR) on cancer cells, which increase their sensitivity to 1,25-dihydroxyvitamin D(3) , the hormonally active form of vitamin D(3) .	Vitamin D	112-121	vitamin D receptor	Homo sapiens	135-138
9792954-14	1998	These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene.	Vitamin D	220-229	retinoid X receptor alpha	Homo sapiens	146-149
17507873-2	2007	Isoflavonoids are also able to raise the serum level of the active form of vitamin D(3) due to their inhibitory activity on CYP24, the enzyme involved in the degradation of 1,25-dihydroxyvitamin D(3) and its precursor 25-OH-D(3) to inactive compounds.	Vitamin D	75-84	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	124-129
9440810-1	1998	The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) and mediates the effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], on gene expression.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
17148678-0	2006	Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals.	Vitamin D	20-29	fibroblast growth factor 23	Mus musculus	96-102
17161336-3	2006	The generation of VDR deficient mice has expanded the knowledge on vitamin D from a calcium-regulating hormone to a humoral factor with extensive actions.	Vitamin D	67-76	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	18-21
16860619-0	2006	The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	140-158
16860619-10	2006	However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p &lt; 0.004).	Vitamin D	42-51	vitamin D receptor	Homo sapiens	134-137
9440810-1	1998	The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) and mediates the effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], on gene expression.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	4-22
16860619-13	2006	CONCLUSIONS: Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	138-141
9440810-1	1998	The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) and mediates the effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], on gene expression.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	24-27
9275211-1	1997	Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	107-125
16932898-6	2006	In chronic dialysis patients without residual renal function, FGF23 levels become extremely high due to stimulation by vitamin D therapy as well as by high levels of serum phosphate and PTH.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	62-67
16932898-7	2006	Recent investigations have demonstrated that serum FGF23 level can be a useful marker for the prediction of the future development of refractory hyperparathyroidism and the response to vitamin D therapy in dialysis patients.	Vitamin D	185-194	fibroblast growth factor 23	Homo sapiens	51-56
9275211-1	1997	Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-130
9275211-3	1997	Studies in kindreds with VDR mutations (vitamin D-dependent rickets type II, VDDR II) have demonstrated hypocalcemia, hyperparathyroidism, rickets, and osteomalacia.	Vitamin D	40-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	25-28
9337080-3	1997	As an additional index of leukaemic cell differentiation, induction of expression of the phenotypic cell surface antigen, CD14, and the beta2-integrins, CD11b and CD18 by the vitamin D and retinoid compounds were monitored using fluorescence activated cell sorting (FACS) analyses.	Vitamin D	175-184	integrin subunit alpha M	Homo sapiens	153-158
16732322-6	2006	Most importantly, we have identified a vitamin D responsive element (VDRE) in the promoter region of the human KSR-1 gene, to which VDR binds in a 1,25D-dependent manner, in vitro and in vivo.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	69-72
9284761-1	1997	Hereditary vitamin D resistant rickets has been associated with a number of mutations within the DNA and ligand binding domains of vitamin D receptors (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	131-150
17086935-1	2006	1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	124-142
17086935-1	2006	1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	144-147
17086935-5	2006	In order to identify VDR ligands with less hypercalcemia liability, a number of pharmaceutical companies are pursuing efforts to develop synthetic vitamin D analogs.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	21-24
17086935-7	2006	The future directions of vitamin D research for the discovery of novel VDR agonists for osteoporosis are also discussed.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	71-74
9284761-1	1997	Hereditary vitamin D resistant rickets has been associated with a number of mutations within the DNA and ligand binding domains of vitamin D receptors (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	152-155
9379127-8	1997	Vitamin D derivatives were also demonstrated to reduce IGF-I receptor expression in MCF-7 cells by Western analysis.	Vitamin D	0-9	insulin like growth factor 1 receptor	Homo sapiens	55-69
9379127-9	1997	Our findings demonstrate that vitamin D derivatives limit responsiveness of MCF-7 cells to the mitogenic effects of IGF-I, which may be mediated by reduction of IGF-I receptor expression.	Vitamin D	30-39	insulin like growth factor 1 receptor	Homo sapiens	161-175
9379138-4	1997	In hereditary hypocalcemic vitamin D-resistant rickets (HVDRR), natural mutations in human VDR that confer patients with tissue insensitivity to 1,25(OH)2D3 are particularly instructive in revealing VDR structure function relationships.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	57-60
16936639-2	2006	In this study, we show that the RXR ligand 9-cis-retinoic acid (9-cis-RA) induces recruitment of coactivators by the DNA-bound heterodimer and potentiates vitamin D-dependent transcriptional responses.	Vitamin D	155-164	retinoid X receptor alpha	Homo sapiens	32-35
9213220-7	1997	In addition, both Gal4-based systems behaved similar with regard to their dose-dependent response to vitamin D and related compounds when compared to the transcriptional activity of the vitamin D receptor in transiently transfected MCF-7 cells.	Vitamin D	101-110	galectin 4	Homo sapiens	18-22
16995817-4	2006	This study indicates that vitamin D-mediated osteoclastogenesis is regulated locally by OPG production in the mature osteoblast.	Vitamin D	26-35	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	88-91
16995817-5	2006	INTRODUCTION: Vitamin D stimulates osteoclastogenesis acting through its nuclear receptor (VDR) in immature osteoblast/stromal cells.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	91-94
9228086-0	1997	Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3.	Vitamin D	63-72	retinoid X receptor alpha	Homo sapiens	0-19
16995817-9	2006	Vitamin D-mediated osteoclastogenesis was examined in vitro using OSVDR osteoblasts and osteoblastic RANKL: osteoprotegerin (OPG) examined in vivo and in vitro after vitamin D treatment.	Vitamin D	0-9	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	108-123
16995817-9	2006	Vitamin D-mediated osteoclastogenesis was examined in vitro using OSVDR osteoblasts and osteoblastic RANKL: osteoprotegerin (OPG) examined in vivo and in vitro after vitamin D treatment.	Vitamin D	0-9	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	125-128
16995817-12	2006	The vitamin D-mediated reduction in OPG expression was reduced in OSVDR osteoblasts in vivo and in vitro, resulting in a reduced RANKL/OPG ratio in OSVDR compared with wildtype, after exposure to vitamin D.	Vitamin D	4-13	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	36-39
16995817-12	2006	The vitamin D-mediated reduction in OPG expression was reduced in OSVDR osteoblasts in vivo and in vitro, resulting in a reduced RANKL/OPG ratio in OSVDR compared with wildtype, after exposure to vitamin D.	Vitamin D	4-13	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	135-138
16995817-12	2006	The vitamin D-mediated reduction in OPG expression was reduced in OSVDR osteoblasts in vivo and in vitro, resulting in a reduced RANKL/OPG ratio in OSVDR compared with wildtype, after exposure to vitamin D.	Vitamin D	196-205	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	36-39
16995817-13	2006	CONCLUSIONS: Mature osteoblasts play an inhibitory role in bone resorption, with active vitamin D metabolites acting through the VDR to increase OPG.	Vitamin D	88-97	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	129-132
16995817-13	2006	CONCLUSIONS: Mature osteoblasts play an inhibitory role in bone resorption, with active vitamin D metabolites acting through the VDR to increase OPG.	Vitamin D	88-97	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	145-148
9228086-0	1997	Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3.	Vitamin D	63-72	retinoid X receptor alpha	Homo sapiens	21-24
9228086-0	1997	Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3.	Vitamin D	63-72	retinoid X receptor alpha	Homo sapiens	102-105
17009074-3	2006	In the development of secondary hyperparathyroidism, it has recently been suggested that fibroblast growth factor 23 (FGF23) plays a crucial role, both as a phosphaturic factor and as a suppressor of active vitamin D (1,25D) production in the kidney.	Vitamin D	207-216	fibroblast growth factor 23	Homo sapiens	89-116
17009074-3	2006	In the development of secondary hyperparathyroidism, it has recently been suggested that fibroblast growth factor 23 (FGF23) plays a crucial role, both as a phosphaturic factor and as a suppressor of active vitamin D (1,25D) production in the kidney.	Vitamin D	207-216	fibroblast growth factor 23	Homo sapiens	118-123
9263679-1	1997	Vitamin D acts on the genome via its active metabolite, calcitriol, which is bound to its nuclear receptor (vitamin D receptor) and a DNA response element.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	108-126
17009074-5	2006	Furthermore, recent data suggest that FGF23 could be another useful marker for the prognosis of hyperparathyroidism, because a high serum level may reflect the cumulative dose of vitamin D analogues previously administered.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	38-43
16598763-5	2006	Transfection studies in CaCo-2 cells with a vitamin D response element-containing construct revealed the involvement of the VDR in this UVB-dependent CYP24 induction.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	124-127
9263679-4	1997	Physiological evidence for heterodimerization of the vitamin D receptor with the retinoid X receptor, and with other liganded or unliganded nuclear receptors, has indicated how the genetic response to vitamin D can be modulated.	Vitamin D	53-62	retinoid X receptor alpha	Homo sapiens	81-100
16598763-5	2006	Transfection studies in CaCo-2 cells with a vitamin D response element-containing construct revealed the involvement of the VDR in this UVB-dependent CYP24 induction.	Vitamin D	44-53	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	150-155
9121440-2	1997	The receptors for 9-cis retinoic acid and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], RXR and VDR, respectively, as members of this superfamily, form a heterodimeric complex and bind cooperatively to vitamin D responsive elements (VDREs) to activate or repress the transcription of a multitude of genes which regulate a variety of physiological functions.	Vitamin D	56-65	retinoid X receptor alpha	Homo sapiens	82-85
16563470-4	2006	Compelling data in mice show that vitamin D and signaling through the vitamin D receptor dictate the outcome of experimental MS and IBD.	Vitamin D	34-43	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	70-88
16502312-5	2006	Cytochrome P450 (CYP27A1, CYP2R1, CYP27B1, CYP24A1) enzymes involved in vitamin D metabolism and two vitamin D(3)-target genes (ECaC1, CaBP-D9K) were assessed by real time RT-PCR in liver and kidneys.	Vitamin D	101-110	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	128-133
9121440-2	1997	The receptors for 9-cis retinoic acid and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], RXR and VDR, respectively, as members of this superfamily, form a heterodimeric complex and bind cooperatively to vitamin D responsive elements (VDREs) to activate or repress the transcription of a multitude of genes which regulate a variety of physiological functions.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	90-93
17551468-0	2006	Vitamin D receptor defects: the story of hereditary resistance to vitamin D.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	0-18
9079669-5	1997	In the current studies 25-[3H]hydroxyvitamin D3 (25-OHD3) was used as a competitive ligand to investigate the ability of a number of small lipid molecules to interact with this intracellular vitamin D-binding protein (IDBP) in post-nuclear extracts of a prototypical lymphoblast cell line from the common marmoset, a vitamin D-resistant New World primate.	Vitamin D	37-46	GC vitamin D binding protein	Homo sapiens	191-216
16886688-1	2006	BACKGROUND: The three main vitamin D metabolizing enzymes, vitamin D3-25-hydroxylase (25-OHase, 25-hydroxylase), 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-OHase, 1alpha-hydroxylase) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase, 24-hydroxylase), have been described in malignant breast tissue.	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	229-237
16886688-3	2006	MATERIALS AND METHODS: Vitamin D receptor (VDR)- positive MCF-7 cells in culture were stimulated with the vitamin D metabolites vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 for 24, 48; 72 and 96 hours in physiological and supraphysiological concentrations.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	23-41
16886688-3	2006	MATERIALS AND METHODS: Vitamin D receptor (VDR)- positive MCF-7 cells in culture were stimulated with the vitamin D metabolites vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 for 24, 48; 72 and 96 hours in physiological and supraphysiological concentrations.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	43-46
9079669-14	1997	In summary, these results suggest a novel action for the hsp-70 family of proteins as intracellular vitamin D- and gonadal steroid hormone-binding molecules.	Vitamin D	100-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	57-63
9099905-0	1997	The noncalcemic vitamin D analogues EB1089 and 22-oxacalcitriol interact with the vitamin D receptor and suppress parathyroid hormone-related peptide gene expression.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	82-100
9191975-1	1997	We previously reported that 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] activates the human osteocalcin gene (hOC) through vitamin D receptor (VDR) and vitamin D responsive element (VDRE) in the same manner as 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2 D3] [17].	Vitamin D	44-53	vitamin D receptor	Homo sapiens	122-140
16750418-2	2006	We analyzed vitamin D receptor (VDR) binding to putative vitamin D response elements within the 5-LO promoter and analyzed its function by reporter gene analysis.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	32-35
16816472-1	2006	CYP27A1, CYP27B1, and CYP24A1 are members of the cytochrome P450 superfamily, and key enzymes of vitamin D(3) metabolism.	Vitamin D	97-106	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	22-29
16816472-8	2006	Surprisingly, more than 70% of the vitamin D metabolites observed in a living body were found to be the products formed by the activities of CYP27A1, CYP27B1, and CYP24A1.	Vitamin D	35-44	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	163-170
16816472-12	2006	Some vitamin D analogs are good substrates for CYP3A1 while CYP24A1 is responsible for metabolism of most of vitamin D analogs.	Vitamin D	5-14	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-67
9191975-1	1997	We previously reported that 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] activates the human osteocalcin gene (hOC) through vitamin D receptor (VDR) and vitamin D responsive element (VDRE) in the same manner as 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2 D3] [17].	Vitamin D	44-53	vitamin D receptor	Homo sapiens	142-145
16816472-12	2006	Some vitamin D analogs are good substrates for CYP3A1 while CYP24A1 is responsible for metabolism of most of vitamin D analogs.	Vitamin D	109-118	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-67
16816473-2	2006	Fibroblast growth factor 23 (FGF23) has been identified as a novel factor that regulates vitamin D and phosphate metabolism.	Vitamin D	89-98	fibroblast growth factor 23	Mus musculus	0-27
27405232-9	1997	However, in HL-60 cells the vitamin D derivatives were capable of preventing the further down-regulation of RXR in the presence of the retinoid.	Vitamin D	28-37	retinoid X receptor alpha	Homo sapiens	108-111
16816473-2	2006	Fibroblast growth factor 23 (FGF23) has been identified as a novel factor that regulates vitamin D and phosphate metabolism.	Vitamin D	89-98	fibroblast growth factor 23	Mus musculus	29-34
16816473-3	2006	Genetic defect of FGF23 in mice revealed not only abnormal vitamin D and phosphate metabolism, but also premature aging-like phenotype that is quite similar to Klotho mice.	Vitamin D	59-68	fibroblast growth factor 23	Mus musculus	18-23
8920918-0	1996	Functional analysis of vitamin D response elements in the parathyroid hormone gene and a comparison with the osteocalcin gene.	Vitamin D	23-32	parathyroid hormone	Bos taurus	58-77
8920918-1	1996	We have previously localised two putative vitamin D response elements (VDRE) in the bovine parathyroid hormone (PTH) gene to within -485 to -452 and -451 to -348 base pairs (bp).	Vitamin D	42-51	parathyroid hormone	Bos taurus	91-110
16603671-7	2006	When aortic rings from normal rats or a primary culture of human coronary artery smooth muscle cells were treated with phosphorus or vitamin D analogs in vitro, high phosphorus induced calcium accumulation and/or 45Ca uptake in a dose- or time-dependent manner, whereas vitamin D analogs including 1alpha(OH)D2 up to 100 nM had no significant effect despite the presence of a functional vitamin D receptor.	Vitamin D	133-142	vitamin D receptor	Homo sapiens	387-405
8920918-1	1996	We have previously localised two putative vitamin D response elements (VDRE) in the bovine parathyroid hormone (PTH) gene to within -485 to -452 and -451 to -348 base pairs (bp).	Vitamin D	42-51	parathyroid hormone	Bos taurus	112-115
8806764-1	1996	Vitamin D binding protein (DBP) plays an essential role in the vitamin D hormone endocrine system in sequestering vitamin D3 and its metabolites with high affinity, and transporting them to various target organs and tissues.	Vitamin D	63-72	D-box binding PAR bZIP transcription factor	Rattus norvegicus	27-30
8816911-1	1996	One of the MMPs, stromelysin-1 (MMP-3) has been localized to extracellular matrix vesicles in growth plate chondrocyte cultures, suggesting involvement of this enzyme in remodeling of the extracellular matrix during endochondral development, a process which is regulated by the vitamin D metabolites, 1,25-(OH)2D3 and 24,25-(OH)2D3.	Vitamin D	278-287	matrix metallopeptidase 3	Rattus norvegicus	17-30
8816911-1	1996	One of the MMPs, stromelysin-1 (MMP-3) has been localized to extracellular matrix vesicles in growth plate chondrocyte cultures, suggesting involvement of this enzyme in remodeling of the extracellular matrix during endochondral development, a process which is regulated by the vitamin D metabolites, 1,25-(OH)2D3 and 24,25-(OH)2D3.	Vitamin D	278-287	matrix metallopeptidase 3	Rattus norvegicus	32-37
8816911-4	1996	Since plasma membrane protein kinase C (PKC) activity is stimulated by 1,25 and 24,25, we hypothesized that stromelysin-1 activity was regulated by the vitamin D metabolites via PKC-dependent phosphorylation.	Vitamin D	152-161	protein kinase C, alpha	Rattus norvegicus	40-43
8816911-4	1996	Since plasma membrane protein kinase C (PKC) activity is stimulated by 1,25 and 24,25, we hypothesized that stromelysin-1 activity was regulated by the vitamin D metabolites via PKC-dependent phosphorylation.	Vitamin D	152-161	matrix metallopeptidase 3	Rattus norvegicus	108-121
16617161-1	2006	Our previous studies revealed the species-based difference of CYP24A1-dependent vitamin D metabolism.	Vitamin D	80-89	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	62-69
8816911-4	1996	Since plasma membrane protein kinase C (PKC) activity is stimulated by 1,25 and 24,25, we hypothesized that stromelysin-1 activity was regulated by the vitamin D metabolites via PKC-dependent phosphorylation.	Vitamin D	152-161	protein kinase C, alpha	Rattus norvegicus	178-181
8816911-10	1996	This suggests that this may be one mechanism by which vitamin D metabolites regulate stromelysin-1 activity and that PKC-dependent phosphorylation inhibits the metalloproteinase.	Vitamin D	54-63	matrix metallopeptidase 3	Rattus norvegicus	85-98
9159226-0	1996	New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulin.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	99-117
16731043-3	2006	Recent in vivo genetic-manipulation studies have shown increased serum level of vitamin D and altered mineral-ion homeostasis in mice that lack either fibroblast growth factor 23 (Fgf23) or klotho (Kl) genes.	Vitamin D	80-89	fibroblast growth factor 23	Mus musculus	151-178
9159226-2	1996	The vitamin D receptor (VDR) forms heterodimers with retinoid X receptors (RXRs) and the dimer then interacts with its cognate binding site, termed vitamin D response element (VDRE), to affect the transcription of target genes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
8807778-2	1996	Vitamin D-induced inhibition of IFN-gamma production was most pronounced in MNL cultures supplemented with 1,25(OH)2D3 at 1.0 nM or more, a concentration equal to or exceeding that in plasma of cows with clinical hypocalcemia.	Vitamin D	0-9	interferon gamma	Bos taurus	32-41
16753019-0	2006	Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	103-121
16753019-1	2006	UNLABELLED: We report here the first association between vitamin D-resistant rickets, alopecia, and type 1 diabetes in a child with compound heterozygous mutations in the VDR gene.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	171-174
16641675-1	2006	Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	104-122
8660573-1	1996	Serum vitamin D binding protein (DBP, also known as Gc-globulin) is a multifunctional protein capable of binding both vitamin D metabolites and actin.	Vitamin D	6-15	GC vitamin D binding protein	Homo sapiens	52-63
16614118-1	2006	Inherited variants of the vitamin D receptor (VDR) gene may influence cancer risk by altering the effect of vitamin D on cell growth and homeostasis.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	46-49
8681462-0	1996	Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	246-264
16690532-1	2006	Although vitamin D analogs are known to induce the differentiation of the HL-60 promyelocytic leukemia cells, the effect of vitamin D analogs on the distribution of vitamin D receptor (VDR) in these cells is not well studied.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	165-183
16690532-1	2006	Although vitamin D analogs are known to induce the differentiation of the HL-60 promyelocytic leukemia cells, the effect of vitamin D analogs on the distribution of vitamin D receptor (VDR) in these cells is not well studied.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	185-188
16690532-6	2006	These results suggest that binding of vitamin D analogs to VDR induced receptor translocation into the nucleus, which stabilizes the receptor, resulting in an accumulation of the VDR protein.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	59-62
16690532-6	2006	These results suggest that binding of vitamin D analogs to VDR induced receptor translocation into the nucleus, which stabilizes the receptor, resulting in an accumulation of the VDR protein.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	179-182
8681462-0	1996	Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	246-264
16613705-1	2006	OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	134-152
8761946-1	1996	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)transactivates the avian beta 3 integrin gene whose promoter contains at least two vitamin D response elements, one of which is in close proximity to a candidate AP1 site (TGACTCA).	Vitamin D	14-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	200-203
16613705-1	2006	OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	154-157
16613705-1	2006	OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets.	Vitamin D	181-190	vitamin D receptor	Homo sapiens	134-152
8650247-5	1996	Responses to vitamin D treatment may also be predicted by vitamin D receptor allelic analysis, though the currently proposed allelic patterns are yet far from being widely accepted.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	58-76
16613705-1	2006	OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets.	Vitamin D	181-190	vitamin D receptor	Homo sapiens	154-157
16613705-10	2006	CONCLUSIONS: There is an association between the VDR gene Fok I polymorphism and vitamin D deficiency rickets.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	49-52
8650247-6	1996	The outlook for vitamin D treatment for osteoporosis may require insight into vitamin D receptor, not only for vitamin D"s given form, but also for a possible future form designed to intervene at the genomic level.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	78-96
8622969-4	1996	Replacement of Ser-208 with glycine or alanine indicates that phosphorylation of hVDR at Ser-208 is not obligatory for 1,25(OH)2D3 action, but coexpression of wild-type hVDR and CK-11 elicits a dose-dependent enhancement of 1,25(OH)2D3-stimulated transcription of a vitamin D responsive element reporter construct.	Vitamin D	266-275	vitamin D receptor	Homo sapiens	81-85
16406653-1	2006	Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	80-98
16406653-1	2006	Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	100-103
16406653-1	2006	Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	167-170
8657749-3	1996	When Ho-0, an elution with n-hexane, and Ho-1 were administrated to the rachitic rats fed with a vitamin D-free, low-phosphorus diet, they not only increased significantly the concentration of inorganic phosphorus in serum, but also significantly promoted bone calcification.	Vitamin D	97-106	heme oxygenase 1	Rattus norvegicus	41-45
16483768-6	2006	Examination of the regulation of VDR target gene mRNA in DU-145 cells revealed that co-treatment of 1,25-(OH)(2)D(3) plus inhibitor of Vitamin D(3) metabolising enzymes co-ordinately upregulated CYP24, p21(waf1/cip1) and GADD45alpha.	Vitamin D	135-144	vitamin D receptor	Homo sapiens	33-36
16483768-6	2006	Examination of the regulation of VDR target gene mRNA in DU-145 cells revealed that co-treatment of 1,25-(OH)(2)D(3) plus inhibitor of Vitamin D(3) metabolising enzymes co-ordinately upregulated CYP24, p21(waf1/cip1) and GADD45alpha.	Vitamin D	135-144	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	195-200
16221703-4	2006	METHODS: We determined the effectiveness of the vitamin D prodrugs 1alpha(OH)D3, 1alpha(OH)D2 and 1alpha(OH)-24(R)-methyl-25-ene-D2 (BCI-210) at inhibiting PTH secretion in bovine parathyroid cell cultures, and examined the metabolism of [3H]1alpha(OH)D2 in these cells.	Vitamin D	48-57	parathyroid hormone	Bos taurus	156-159
16339300-1	2006	BACKGROUND: Clinical assessment of vitamin D status often relies on measuring total circulating 25-hydroxyvitamin D3 (25OHD3), but much of each vitamin D metabolite is bound to plasma vitamin D-binding protein (DBP), such that the percentage of free vitamin is very low.	Vitamin D	35-44	GC vitamin D binding protein	Homo sapiens	184-209
16243370-3	2006	This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR).	Vitamin D	39-48	vitamin D receptor	Homo sapiens	164-182
16243370-3	2006	This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR).	Vitamin D	39-48	vitamin D receptor	Homo sapiens	68-71
15987715-9	2006	These findings support the idea that vitamin D-based therapies might be beneficial in the management of advanced prostate cancer, especially among patients who have higher MMP-9 and CPs activities.	Vitamin D	37-46	matrix metallopeptidase 9	Homo sapiens	172-177
16958596-8	2006	Serum 25OH vitamin D levels, assessed in only 63 probands, were significantly associated with VDR genotypes (ANCOVA, p&lt;or=0.0027).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	94-97
16848738-1	2006	The vitamin D receptor (VDR) is an endocrine member of the nuclear receptor superfamily and binds the biologically most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
16269453-9	2006	Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	18-21
16269453-9	2006	Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex.	Vitamin D	85-94	mediator complex subunit 1	Homo sapiens	129-136
16269453-9	2006	Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	145-148
16622734-1	2006	Vitamin D (Vit D) is an essential element for the regulation of serum calcium, phosphate, and alkaline phosphatase (Alk Ph).	Vitamin D	0-9	ALK receptor tyrosine kinase	Homo sapiens	116-119
16374421-0	2006	Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	67-85
17002490-1	2006	black triangle An oral formulation of paricalcitol has been developed for the prevention and treatment of secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease.black triangle Paricalcitol is a synthetic vitamin D analog that binds to the vitamin D receptor inducing suppression of parathyroid hormone (PTH) secretion.black triangle Oral paricalcitol was significantly more effective than placebo in treating secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease.	Vitamin D	232-241	vitamin D receptor	Homo sapiens	267-285
16202592-2	2005	The weighted holistic invariant molecular (WHIM) approach has been applied to the study of the VDR affinity of 86 vitamin D analogues.	Vitamin D	114-123	vitamin D receptor	Homo sapiens	95-98
16203744-2	2005	The transcriptional factors SNAIL and ZEB1 are involved in its repression, whereas activation of vitamin D receptor (VDR) by vitamin D induces its transcription.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	117-120
16214913-2	2005	The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D and additionally interacts with other cell-signaling pathways that influence cancer development.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
16202933-9	2005	Vitamin D receptor is expressed in all calcium-regulated tissues, including the ovary; thus, calcium and vitamin D appear to be necessary for full ovarian function.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	0-18
16046118-1	2005	1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	233-251
16055325-5	2005	Along these lines we have recently proposed a Vitamin D sterol/VDR conformational ensemble model that posits the VDR contains two distinct, yet overlapping ligand binding sites, and that the potential differential stabilities of 1,25D and HL in these two pockets can be used to explain their different non-genomic signaling properties.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	63-66
16055325-5	2005	Along these lines we have recently proposed a Vitamin D sterol/VDR conformational ensemble model that posits the VDR contains two distinct, yet overlapping ligand binding sites, and that the potential differential stabilities of 1,25D and HL in these two pockets can be used to explain their different non-genomic signaling properties.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	113-116
16055325-9	2005	This model may provide new insights into how Vitamin D sterols that uncouple the unwanted hypercalcemic effect from attractive growth inhibitory/differentiation properties can do so by differentially stabilizing different subpopulations of VDR conformational ensemble members.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	240-243
16369193-4	2005	Actions of vitamin D are mediated by the binding of 1, 25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	98-116
16369193-4	2005	Actions of vitamin D are mediated by the binding of 1, 25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	118-121
15961556-9	2005	The destabilizing nature of these mutations provides new insight into the pathophysiology of TC and exemplifies the physiological importance of FGF23 in phosphate and vitamin D metabolism.	Vitamin D	167-176	fibroblast growth factor 23	Homo sapiens	144-149
20704880-7	2005	Also, certain genetic variations in components of the vitamin D system such as the vitamin D receptor (VDR) account for an increased risk for type 1 diabetes.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	83-101
20704880-7	2005	Also, certain genetic variations in components of the vitamin D system such as the vitamin D receptor (VDR) account for an increased risk for type 1 diabetes.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	103-106
8603577-11	1996	Cells carrying the 1.1-kb promoter show DNase I hypersensitivity at both the basal promoter and the vitamin D response element-containing domains, locations that also exhibit DNase I hypersensitivity in the endogenous OC promoter.	Vitamin D	100-109	deoxyribonuclease 1	Rattus norvegicus	40-47
15798098-7	2005	This review deals with the molecular aspects of noncalcemic actions of vitamin D analogs that account for the efficacy of VDR ligands in the above-mentioned indications.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	122-125
8552086-0	1996	A composite element binding the vitamin D receptor, retinoid X receptor alpha, and a member of the CTF/NF-1 family of transcription factors mediates the vitamin D responsiveness of the c-fos promoter.	Vitamin D	32-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-190
15951480-3	2005	This vitamin D hormone activates its cellular receptor (vitamin D receptor or VDR), which alters the transcription rates of target genes responsible for the biological responses.	Vitamin D	5-14	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	56-74
15951480-3	2005	This vitamin D hormone activates its cellular receptor (vitamin D receptor or VDR), which alters the transcription rates of target genes responsible for the biological responses.	Vitamin D	5-14	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	78-81
8552086-1	1996	The hormonal form of vitamin D, 1 alpha,25-dihydroxyvitamin D3 [1,25- (OH)2D3], transiently stimulates the transcription of the c-fos proto-oncogene in osteoblastic cells.	Vitamin D	21-30	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-133
8552086-2	1996	We have identified and characterized a vitamin D response element (VDRE) in the promoter of c-fos.	Vitamin D	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-97
8566748-1	1996	The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor (vitamin D3 receptor, VDR) will induce myeloid leukemic cell lines to terminally differentiate into monocytes/macrophages.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	103-122
15930999-4	2005	Several animal experiments including overexpression or ablation of the FGF23 gene have recently revealed the significant effects of this factor on phosphate excretion and on vitamin D synthesis in the kidney.	Vitamin D	174-183	fibroblast growth factor 23	Homo sapiens	71-76
15931003-1	2005	PURPOSE OF REVIEW: Although the active metabolite of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is classically appreciated to exert its calcemic and other actions via interaction with the vitamin D receptor, thereby modulating gene transcription, some of its actions cannot be explained in this way when examined in vitro.	Vitamin D	53-62	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	194-212
8566748-1	1996	The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor (vitamin D3 receptor, VDR) will induce myeloid leukemic cell lines to terminally differentiate into monocytes/macrophages.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	124-127
15917335-3	2005	Several hypotheses were tested: that FGF-23 increases as renal function declines; is linearly associated with serum phosphate levels; is associated with increased phosphaturia independent of parathyroid hormone (PTH); and is associated with decreased calcitriol levels independent of renal function, hyperphosphatemia, and vitamin D stores.	Vitamin D	323-332	fibroblast growth factor 23	Homo sapiens	37-43
8964569-0	1996	Nonhypercalcemic vitamin D analogs: interactions with the vitamin D-binding protein.	Vitamin D	17-26	GC vitamin D binding protein	Homo sapiens	58-83
15650022-0	2005	Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d receptor.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	189-207
8547182-13	1995	17 beta-HSD 4 expression is not altered by phorbolester treatment in undifferentiated cells but is abolished after vitamin D-propagated differentiation along with downregulation of beta-actin.	Vitamin D	115-124	RNA, U1 small nuclear 3	Homo sapiens	8-13
8614417-9	1995	These results suggest that vitamin D analogs do indeed confer biological effects by acting directly and differentially at the level of VDR, and that specific vitamin D analogs can act on distinct receptor functions.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	135-138
7575575-3	1995	The T-box mutant hVDR displayed attenuated vitamin D responsive element (VDRE) binding in the presence of RXR and was severely compromised in transcriptional activation.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	17-21
7575575-3	1995	The T-box mutant hVDR displayed attenuated vitamin D responsive element (VDRE) binding in the presence of RXR and was severely compromised in transcriptional activation.	Vitamin D	43-52	retinoid X receptor alpha	Homo sapiens	106-109
8577633-2	1995	The effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25 (OH)2D3), are mediated by binding to a specific intracellular vitamin D receptor, which is present in most tissues including the skin where it regulates the growth of epidermal cells.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	151-169
7558419-5	1995	Although the antiproliferative effect of the vitamin-D sterols requires high-affinity binding to the cytoplasmic vitamin-D receptor (VDR), vitamin-D sterols have no effect on VDR mRNA levels in Caco-2 cells.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	113-131
7558419-5	1995	Although the antiproliferative effect of the vitamin-D sterols requires high-affinity binding to the cytoplasmic vitamin-D receptor (VDR), vitamin-D sterols have no effect on VDR mRNA levels in Caco-2 cells.	Vitamin D	113-122	vitamin D receptor	Homo sapiens	133-136
7558419-7	1995	This suggests that VDR mRNA abundance could nevertheless be important for vitamin-D-related c-myc-independent growth control in Caco-2 cells.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	19-22
7649081-11	1995	Normalization of PTH/PTHrp receptor mRNA expression was observed after vitamin D supplementation (D-D+ rats), but not after correction of the hypocalcemia and secondary hyperparathyroidism by oral lactose and calcium supplementation.	Vitamin D	71-80	parathyroid hormone-like hormone	Rattus norvegicus	21-26
7649081-12	1995	In the epi/metaphysis, an approximately 2-fold increase in PTH/PTHrp receptor mRNA was also observed in the D-D- rats compared to the controls; this increase was partially corrected upon normalization of the calcemia and PTH levels with either vitamin D (D-D+ group) or lactose/calcium (D-Ca+ group).	Vitamin D	244-253	parathyroid hormone-like hormone	Rattus norvegicus	63-68
7673427-11	1995	These data indicate that the VDR alleles are associated with differences in the vitamin D endocrine system and may have important implications in relation to the pathophysiology of osteoporosis.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	29-32
7622489-0	1995	Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism.	Vitamin D	127-136	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	108-113
7622489-5	1995	We conclude that CYP24 must be directed to its hydroxylation site(s) by the distance of carbon 24 from the vitamin D ring structure and not as in CYP27 by the distance of the hydroxylation site from the end of the side chain.	Vitamin D	107-116	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	17-22
7552094-1	1995	The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with the vitamin D response elements of the target genes.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	97-100
7632609-2	1995	Vitamin D-binding protein (DBP), a multifunctional, highly polymorphic glycoprotein responsible for the transport of vitamin D and for sequestering extracellular actin, was isolated from human serum and crystallized using vapour diffusion methods.	Vitamin D	117-126	GC vitamin D binding protein	Homo sapiens	0-25
21153172-0	1995	Pharmacokinetic studies of vitamin D analogues: relationship to vitamin D binding protein (DBP).	Vitamin D	27-36	D-box binding PAR bZIP transcription factor	Rattus norvegicus	91-94
21153172-2	1995	During the development of synthetic vitamin D analogues, it has been shown that the majority of analogues bind to DBP with a low affinity.	Vitamin D	36-45	D-box binding PAR bZIP transcription factor	Rattus norvegicus	114-117
21153172-8	1995	In the group of vitamin D analogues which showed a low or no affinity for DBP, we have identified compounds with a short t(1/2) and compounds with a long t(1/2), all characterized by low initial serum levels.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Rattus norvegicus	74-77
21153172-10	1995	These results showed that the initial serum level of vitamin D analogues correlated with the affinity for DBP, but that there seemed to be no correlation with the metabolic rate as reflected by measurement of the serum half-life of the analogues.	Vitamin D	53-62	D-box binding PAR bZIP transcription factor	Rattus norvegicus	106-109
7626415-1	1995	The basic features on the vitamin D endocrine system, synthesis of the main metabolite 1,25-dihydroxyvitamin D3 (1,25) and its genomic action mediated via the vitamin D receptor (VDR), are reviewed.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	159-177
7626415-1	1995	The basic features on the vitamin D endocrine system, synthesis of the main metabolite 1,25-dihydroxyvitamin D3 (1,25) and its genomic action mediated via the vitamin D receptor (VDR), are reviewed.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	179-182
7626415-4	1995	Then, the basis of the systemic theory of vitamin D action on teeth (clinical and experimental data and the dissimilar distribution of VDR and of potential vitamin D-dependent proteins in dental cells) are exposed.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	135-138
7531847-6	1995	The results support a role for vitamin D in the control of prostate tumor growth, mediated at least in part by interaction with IGFs and specific IGFBPs.	Vitamin D	31-40	insulin like growth factor binding protein 4	Homo sapiens	146-152
7890807-2	1994	Earlier work from our laboratories has indicated that vitamin D regulation is at the level of transcription, based on results from both nuclear run-off assays and functional promoter analysis of a hybrid gene consisting of a 3.6 kb COL1A1 promoter fragment fused to the chloramphenicol acetyltransferase reporter gene.	Vitamin D	54-63	collagen type I alpha 1 chain	Homo sapiens	232-238
7890807-3	1994	In the present study, we investigated the molecular basis for vitamin D-mediated transcriptional repression of the COL1A1 gene and report the identification of a region within the COL1A1 upstream promoter (the HindIII-Pstl restriction fragment between nucleotides -2295 and -1670) which is necessary for 1,25-dihydroxyvitamin D3 responsiveness in osteoblastic cells.	Vitamin D	62-71	collagen type I alpha 1 chain	Homo sapiens	115-121
7890807-3	1994	In the present study, we investigated the molecular basis for vitamin D-mediated transcriptional repression of the COL1A1 gene and report the identification of a region within the COL1A1 upstream promoter (the HindIII-Pstl restriction fragment between nucleotides -2295 and -1670) which is necessary for 1,25-dihydroxyvitamin D3 responsiveness in osteoblastic cells.	Vitamin D	62-71	collagen type I alpha 1 chain	Homo sapiens	180-186
7890807-8	1994	These results indicate that a vitamin D response element similar to that described for other vitamin D responsive genes (osteocalcin and osteopontin) does not alone mediate the repression of COL1A1 by 1,25-dihydroxyvitamin D3.	Vitamin D	30-39	collagen type I alpha 1 chain	Homo sapiens	191-197
7890807-8	1994	These results indicate that a vitamin D response element similar to that described for other vitamin D responsive genes (osteocalcin and osteopontin) does not alone mediate the repression of COL1A1 by 1,25-dihydroxyvitamin D3.	Vitamin D	93-102	collagen type I alpha 1 chain	Homo sapiens	191-197
7986828-1	1994	The vitamin D receptor (VDR) is a nuclear transcription factor which binds to the vitamin D response element (VDRE) of the human osteocalcin gene and regulates its expression.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
8076631-1	1994	The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines.	Vitamin D	97-106	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-40
8076631-1	1994	The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	45-63
8076631-1	1994	The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	65-68
15862832-7	2005	In addition, evidence that the model is consistent with the pH requirement for Vitamin D sterol-VDR crystallization will be presented.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	96-99
15752725-8	2005	Based on these results, the enzyme(s) responsible for the epimerization of vitamin D(3) at C-3 are thought to be located in microsomes and different from cytochrome P450 and HSE.	Vitamin D	75-84	complement C3	Homo sapiens	91-94
15578590-4	2005	We also show that LCA-VDR stimulates transcription of gene reporter constructs containing DR3 and ER6 vitamin D responsive elements (VDREs) from the human CYP3A4 gene.	Vitamin D	102-111	vitamin D receptor	Homo sapiens	22-25
15857747-1	2005	The hormonal form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1,25D), generates many biological actions by interactions with its nuclear receptor (VDR).	Vitamin D	21-30	vitamin D receptor	Homo sapiens	150-153
15698453-9	2005	The pretreatment FGF-23 levels were related to the iPTH levels, calcium x phosphate product levels, and history of active vitamin D therapy.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	17-23
16278774-4	2005	These are the vitamin D receptor as well as two major vitamin D metabolising enzymes, CYP27B1, responsible for synthesis of 1,25(OH)2D and CYP24, responsible for catabolism of vitamin D metabolites.	Vitamin D	14-23	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	139-144
16278774-4	2005	These are the vitamin D receptor as well as two major vitamin D metabolising enzymes, CYP27B1, responsible for synthesis of 1,25(OH)2D and CYP24, responsible for catabolism of vitamin D metabolites.	Vitamin D	54-63	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	139-144
15498883-9	2005	Keratinocytes from VDR-null mice failed to metabolize [1beta-3H]1alpha,25(OH)2D3 confirming the importance of vitamin D-inducible, VDR-mediated, C24 oxidation pathway in target cells.	Vitamin D	110-119	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	19-22
15498883-9	2005	Keratinocytes from VDR-null mice failed to metabolize [1beta-3H]1alpha,25(OH)2D3 confirming the importance of vitamin D-inducible, VDR-mediated, C24 oxidation pathway in target cells.	Vitamin D	110-119	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	131-134
15498883-10	2005	These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis.	Vitamin D	165-174	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	154-161
15589699-8	2005	The observed distribution of the VDR is consistent with the proposal that Vitamin D operates in a similar fashion to the known neurosteroids.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	33-36
15489543-1	2005	The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, mediates the biological actions of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
15564440-5	2004	The vitamin D hormone (1,25-dihydroxy vitamin D(3)) regulates T helper cell (Th1) and dendritic cell function while inducing regulatory T-cell function.	Vitamin D	4-13	negative elongation factor complex member C/D	Homo sapiens	77-80
15308610-1	2004	Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	108-126
15308610-1	2004	Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
15448105-2	2004	Vitamin D acts via its receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	33-36
15358094-6	2004	The information obtained in this study is quite useful for understanding substrate recognition of CYP24A1 and designing new vitamin D analogs.	Vitamin D	124-133	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	98-105
15353333-7	2004	At present, six cytochrome P450s (CYP2C11, 27A1, 2D25, 2R1, 3A4, and 2J3) are found to exhibit vitamin D 25-hydroxylation activities, and CYP27B1 and CYP24 are proved to be 1 alpha-hydroxylase and 24-hydroxylase, respectively.	Vitamin D	95-104	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	150-155
15295697-10	2004	These findings demonstrate the potential clinical relevance of immunomodulatory functions of vitamin D metabolites acting via the VDR in the host response against pulmonary TB.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	130-133
15261298-1	2004	Compounds (6a-e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D(3), and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC(50)=0.7-24.5 microM).	Vitamin D	107-116	cell division cycle 25A	Homo sapiens	208-214
15288775-0	2004	Rapid vitamin D-dependent PKC signaling shares features with estrogen-dependent PKC signaling in cartilage and bone.	Vitamin D	6-15	protein kinase C, alpha	Rattus norvegicus	26-29
15275953-5	2004	This study confirms the important role of the vitamin D system in motor functions and suggests that animal genetic models targeting the vitamin D/VDR system may be a useful tool to study vitamin D-related motor/behavioural disorders.	Vitamin D	46-55	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	146-149
15219879-8	2004	The effect of vitamin D on reproduction has been further endorsed by murine gene knockout models for 1alpha-hydroxylase and VDR, both of which are infertile.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	124-127
15190891-1	2004	INTRODUCTION: Hereditary vitamin D--resistant rickets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	111-129
15190891-1	2004	INTRODUCTION: Hereditary vitamin D--resistant rickets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	56-59
15109656-1	2004	Novel vitamin D(3) analogs having a lactam structure in their side chains, 1 alpha,25-dihydroxyvitamin D(3)-26,23-lactams (DLAMs), were designed based on the principle of regulation of the folding of helix-12 in the vitamin D nuclear receptor (VDR).	Vitamin D	6-15	vitamin D receptor	Homo sapiens	216-242
15109656-1	2004	Novel vitamin D(3) analogs having a lactam structure in their side chains, 1 alpha,25-dihydroxyvitamin D(3)-26,23-lactams (DLAMs), were designed based on the principle of regulation of the folding of helix-12 in the vitamin D nuclear receptor (VDR).	Vitamin D	6-15	vitamin D receptor	Homo sapiens	244-247
15039597-8	2004	An association between the expression level of the vitamin D receptor (VDR) and EB1089 sensitivity was observed, suggesting that VDR is a possible predictive marker for response to vitamin D treatment.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	71-74
15039597-8	2004	An association between the expression level of the vitamin D receptor (VDR) and EB1089 sensitivity was observed, suggesting that VDR is a possible predictive marker for response to vitamin D treatment.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	129-132
15577039-1	2004	Recent studies indicate that FGF-23, which was originally identified as an endogenous causative factor for hypophosphatemic diseases, is a physiologic factor for the regulation of phosphate homeostasis and vitamin D metabolism.	Vitamin D	206-215	fibroblast growth factor 23	Homo sapiens	29-35
15225755-1	2004	All Vitamin D analogs possessing the A ring modified at C-2 and showing calcemic activities nest themselves in the VDR binding pocket, oriented towards Tyr 143.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	115-118
15225763-0	2004	Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS).	Vitamin D	14-23	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	41-46
15225763-7	2004	Similar experiments using the same wild type and CYP24-XO animals and cells and [3H] 1alpha-OH-D2 resulted in the apparent paradox that the Vitamin D prodrug was 25-hydroxylated in vivo but 24-hydroxylated in vitro.	Vitamin D	140-149	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	49-54
15225803-7	2004	In contrast to non-lesioned rats, in lesioned animals a significant increase in heat shock protein-32 expression occurred which was slightly, but non-significantly altered in the groups treated either with 1alpha,25-(OH)(2)-vitamin D(3) or 17beta-estradiol alone when compared to the solvent-treated control group.	Vitamin D	224-233	heme oxygenase 1	Rattus norvegicus	80-101
15225804-4	2004	Additionally, modulation of cell proliferation by calpain inhibitors, as well as regulation of mRNA expression of VDR, 1alpha-OHase, and 24-OHase genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR, respectively.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	114-117
15225804-4	2004	Additionally, modulation of cell proliferation by calpain inhibitors, as well as regulation of mRNA expression of VDR, 1alpha-OHase, and 24-OHase genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR, respectively.	Vitamin D	155-164	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	137-145
15225805-0	2004	PTH-1R responses to PTHrP and regulation by vitamin D in keratinocytes and adjacent fibroblasts.	Vitamin D	44-53	parathyroid hormone 1 receptor	Rattus norvegicus	0-6
15225805-8	2004	Vitamin D deficiency in weaned rats increased the expression of PTHrP mRNA in keratinocytes, and decreased it in fibroblasts and kidneys.	Vitamin D	0-9	parathyroid hormone-like hormone	Rattus norvegicus	64-69
15225805-9	2004	Vitamin D deficiency increased PTH-1R mRNA expression in keratinocytes and kidneys, but not in fibroblasts.	Vitamin D	0-9	parathyroid hormone 1 receptor	Rattus norvegicus	31-37
15225805-11	2004	Moreover vitamin D regulates PTHrP and PTH-1R in a cell-specific manner.	Vitamin D	9-18	parathyroid hormone-like hormone	Rattus norvegicus	29-34
15225805-11	2004	Moreover vitamin D regulates PTHrP and PTH-1R in a cell-specific manner.	Vitamin D	9-18	parathyroid hormone 1 receptor	Rattus norvegicus	39-45
14758446-8	2004	Higher IL1 expression was detected in islets of vitamin D-deficient mice and their peritoneal macrophages had an aberrant cytokine profile (low IL1 and IL6, high IL15).	Vitamin D	48-57	interleukin 15	Mus musculus	162-166
14978251-6	2004	Vitamin D stimulated endogenous SULT2A1 expression and induced transfected human, mouse, and rat SULT2A1 promoters in liver and intestinal cells upon cotransfection with VDR.	Vitamin D	0-9	sulfotransferase family 2A member 1	Homo sapiens	32-39
14760115-2	2004	CYP24 leads to abrogate growth control mediated by vitamin D.	Vitamin D	51-60	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-5
15084353-9	2004	Vitamin D analogs prevented the antagonistic effect of RAL in the presence of E(2), possibly due to increased numbers of ERs.	Vitamin D	0-9	RAS like proto-oncogene A	Homo sapiens	55-58
15576951-4	2004	Hypercalcemia, uncontrollable hyperphosphatemia, low ALP, and low PTH might impair the vitamin D introduction.	Vitamin D	87-96	ATHS	Homo sapiens	53-56
14730505-6	2004	Furthermore, VDR function, as a transcriptional regulator of vitamin D responsive genes, is impaired by several factors including hypocalcemia, hyperphosphatemia, accumulation of uremic toxins, and reduction in cellular levels of the VDR partner, retinoid X receptor.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	13-16
14730505-6	2004	Furthermore, VDR function, as a transcriptional regulator of vitamin D responsive genes, is impaired by several factors including hypocalcemia, hyperphosphatemia, accumulation of uremic toxins, and reduction in cellular levels of the VDR partner, retinoid X receptor.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	234-237
12959989-2	2003	To determine physiological roles of vitamin D actions through vitamin D receptor (VDR) in skeletal muscle development, we examined skeletal muscle in VDR gene deleted (VDR -/-) mice, an animal model of vitamin D-dependent rickets type II, for morphological changes and expression of myoregulatory transcription factors and myosin heavy chain isoforms.	Vitamin D	36-45	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	82-85
12959989-7	2003	The present study can form a molecular basis of VDR actions on muscle and should help further establish the physiological roles of VDR in muscle development as well as pharmacological effects of vitamin D on muscle functions.	Vitamin D	195-204	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	48-51
12960019-2	2003	To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR).	Vitamin D	38-47	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	328-351
12960019-2	2003	To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR).	Vitamin D	38-47	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	353-355
14598385-3	2003	This process is vitamin D-dependent, largely localized in the duodenum, and involves three steps: entry across the brush border, mediated by a molecular structure, CaT1, with two components; a facilitated transport that saturates at low luminal calcium concentration; and a channel component through which most calcium enters the cell at the higher luminal concentrations.	Vitamin D	16-25	transient receptor potential cation channel subfamily V member 6	Homo sapiens	164-168
12893881-9	2003	Both DRIP205 and SRC-3 potentiated vitamin D-induced transcription in proliferating cells, but during differentiation, DRIP205 was no longer effective.	Vitamin D	35-44	mediator complex subunit 1	Homo sapiens	5-12
14631893-4	2003	The effects of vitamin D are mediated by the nuclear vitamin D receptor, which heterodimerizes with the retinoid X receptor and changes gene transcription.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	53-71
14631893-4	2003	The effects of vitamin D are mediated by the nuclear vitamin D receptor, which heterodimerizes with the retinoid X receptor and changes gene transcription.	Vitamin D	15-24	retinoid X receptor alpha	Homo sapiens	104-123
12865334-4	2003	IL-7 also inhibited (P &lt; 0.05) OCL formation in bone marrow cultures that were stimulated with vitamin D(3) (10(-8) M, 60%), bovine PTH (bPTH) (100 ng/ml, 54%), or RANKL alone (30 ng/ml, 50%).	Vitamin D	98-107	interleukin 7	Bos taurus	0-4
12858337-4	2003	Based on the assumption that VDR inactivation and vitamin D stimulation cause opposite changes in the expression of vitamin D target genes, we identified 95 genes that displayed the same changes in the two VDR-null/wild-type comparisons but an opposite change in the third assay, of which 28 genes were up-regulated and 67 were down-regulated in VDR null mice.	Vitamin D	50-59	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	206-209
12858337-4	2003	Based on the assumption that VDR inactivation and vitamin D stimulation cause opposite changes in the expression of vitamin D target genes, we identified 95 genes that displayed the same changes in the two VDR-null/wild-type comparisons but an opposite change in the third assay, of which 28 genes were up-regulated and 67 were down-regulated in VDR null mice.	Vitamin D	50-59	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	206-209
12858337-4	2003	Based on the assumption that VDR inactivation and vitamin D stimulation cause opposite changes in the expression of vitamin D target genes, we identified 95 genes that displayed the same changes in the two VDR-null/wild-type comparisons but an opposite change in the third assay, of which 28 genes were up-regulated and 67 were down-regulated in VDR null mice.	Vitamin D	116-125	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	29-32
12858337-4	2003	Based on the assumption that VDR inactivation and vitamin D stimulation cause opposite changes in the expression of vitamin D target genes, we identified 95 genes that displayed the same changes in the two VDR-null/wild-type comparisons but an opposite change in the third assay, of which 28 genes were up-regulated and 67 were down-regulated in VDR null mice.	Vitamin D	116-125	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	206-209
12858337-4	2003	Based on the assumption that VDR inactivation and vitamin D stimulation cause opposite changes in the expression of vitamin D target genes, we identified 95 genes that displayed the same changes in the two VDR-null/wild-type comparisons but an opposite change in the third assay, of which 28 genes were up-regulated and 67 were down-regulated in VDR null mice.	Vitamin D	116-125	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	206-209
12858342-0	2003	Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter.	Vitamin D	54-63	TNF superfamily member 11	Homo sapiens	90-95
12858342-5	2003	Both electrophoresis mobility shift assay (EMSA) and transfection studies demonstrated that 1alpha,25(OH)(2)D(3) activated human RANKL promoter through vitamin D responsive elements (VDRE) located at -1584/-1570 by binding VDR and RXRalpha heterodimers in a ligand-dependent manner.	Vitamin D	152-161	TNF superfamily member 11	Homo sapiens	129-134
12858342-5	2003	Both electrophoresis mobility shift assay (EMSA) and transfection studies demonstrated that 1alpha,25(OH)(2)D(3) activated human RANKL promoter through vitamin D responsive elements (VDRE) located at -1584/-1570 by binding VDR and RXRalpha heterodimers in a ligand-dependent manner.	Vitamin D	152-161	vitamin D receptor	Homo sapiens	183-186
12843155-2	2003	Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	78-96
12843155-2	2003	Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	98-101
12843155-2	2003	Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	114-117
12840219-1	2003	The vitamin D-3 receptor (VDR) is a nuclear receptor that modulates gene expression when complexed with its ligand 1-alpha,25-dihydroxycholecalciferol [1,25(OH)(2)-D(3)], which is the biologically active form of vitamin D-3.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	26-29
12840219-2	2003	The cellular effects of VDR signaling include growth arrest, differentiation and/or induction of apoptosis, which indicate that the vitamin D pathway participates in negative-growth regulation.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	24-27
12840219-5	2003	Furthermore, preclinical studies show that vitamin D compounds can reduce breast cancer development in animals, and human data indicate that both vitamin D status and genetic variations in the VDR may affect breast cancer risk.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	193-196
14746673-14	2003	CONCLUSION: There is an association between VDR gene start codon polymorphism and vitamin D deficiency rickets.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	44-47
14746673-15	2003	This study suggested the possibility that VDR gene polymorphism might be important in determining an individual"s susceptibility to development of vitamin D deficiency rickets.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	42-45
12837248-6	2003	Furthermore, overexpression of WSTF could restore the impaired recruitment of VDR to vitamin D regulated promoters in fibroblasts from Williams syndrome patients.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	78-81
12753256-0	2003	Vitamin D receptor: mechanisms for vitamin D resistance in renal failure.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	0-18
12753256-5	2003	Early interventions with 1,25(OH)2D3 could delay the onset of vitamin D resistance by preventing both 1,25(OH)2D3 deficiency and its critical consequence, reduction in VDR content.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	168-171
12519781-9	2003	Moreover, for the first time, they define a potential role for FGF23 in dissociating parathyroid hormone actions on mineral fluxes and on vitamin D metabolism at the level of the kidney.	Vitamin D	138-147	fibroblast growth factor 23	Mus musculus	63-68
12520531-5	2003	VDRE-BP competed in trans with the VDR-retinoid X receptor (RXR) for binding to the vitamin D response element.	Vitamin D	84-93	retinoid X receptor alpha	Homo sapiens	35-58
12520531-5	2003	VDRE-BP competed in trans with the VDR-retinoid X receptor (RXR) for binding to the vitamin D response element.	Vitamin D	84-93	retinoid X receptor alpha	Homo sapiens	60-63
12520531-6	2003	VDRE-BP-legislated resistance to 1,25-(OH)(2)D was antagonized (i.e., compensated) by another set of constitutively overexpressed proteins, the hsp-70-related intracellular vitamin D binding proteins (IDBPs).	Vitamin D	173-182	heat shock protein family A (Hsp70) member 4	Homo sapiens	144-150
12520535-1	2003	Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25-(OH)(2)D(3)] action on calcium homeostasis.	Vitamin D	216-225	vitamin D receptor	Homo sapiens	54-72
12520535-1	2003	Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25-(OH)(2)D(3)] action on calcium homeostasis.	Vitamin D	216-225	vitamin D receptor	Homo sapiens	74-77
12617040-3	2003	On the other hand, vitamin D compounds are known to have multiple actions in many organs (promotion of calcium absorption from the small intestine, induction of differentiation of leukemia cells, differentiation and proliferation of the chondrocyte, muscle cells and epidermal cells, immunosuppressive activities) and their activities on parathyroid glands seem to be mediated by the vitamin D receptor (genomic action).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	384-402
12899528-2	2003	We have now characterized the key components of the vitamin D system (VDR, 1alpha-OHase, 24-OHase and 25-OHase) in cutaneous basal cell carcinomas (BCC) and squamous cell carcinomas (SCC), using immunohistochemical and quantitative real-time PCR techniques.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	70-73
12899530-2	2003	We focused on the structure-activity relationships of the A-ring moiety of the vitamin D molecule and found several strong agonists of the vitamin D receptor, using a design of introducing a functional group into the C2 position.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	139-157
12899537-5	2003	The phytoestrogen genistein was shown to regulate different cytochrome P450 enzymes, a family of proteins to which both of the vitamin D-metabolizing CYP27B1 (1alpha-hydroxylase) and CYP24 (24-hydroxylase) belong.	Vitamin D	127-136	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	183-188
12460926-0	2002	AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	101-122
12454321-9	2002	RESULTS: Vitamin D status was the sole determinant of circulating MMP9 (inversely) and an independent determinant of CRP (inversely).	Vitamin D	9-18	matrix metallopeptidase 9	Homo sapiens	66-70
12444900-2	2002	Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vitamin D receptor (VDR) is involved in regulation of the calcium homeostasis together with PTH.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	74-92
12444900-2	2002	Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vitamin D receptor (VDR) is involved in regulation of the calcium homeostasis together with PTH.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	94-97
12413773-2	2002	We also studied the association between VDR gene polymorphisms and the response to vitamin D (VD) topical treatment in psoriatic patients.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	40-43
12324654-0	2002	Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells.	Vitamin D	64-73	C-X-C motif chemokine receptor 5	Homo sapiens	22-27
12324654-0	2002	Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells.	Vitamin D	64-73	C-X-C motif chemokine receptor 5	Homo sapiens	28-32
12237325-3	2002	In this study, we investigated structurally and functionally important amino acid interactions within the ligand binding pocket of the full-length VDR in the presence of several synthetic vitamin D(3) analogs.	Vitamin D	188-197	vitamin D receptor	Homo sapiens	147-150
12181175-4	2002	nVDR was inversely related to the vitamin D-induced levels of CaT1 mRNA, CaBP mRNA, PMCA mRNA, and net CaTx, with the highest induction seen in BBe.	Vitamin D	34-43	transient receptor potential cation channel subfamily V member 6	Homo sapiens	62-66
12211444-6	2002	In conclusion, this case report of a new family with hereditary vitamin D-resistant rickets (HVDRR) emphasizes the crucial role of the VDR tryptophan for ligand binding and for transactivation of 1,25(OH)2D3 target genes.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	94-97
11983707-0	2002	The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition.	Vitamin D	53-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
11983707-0	2002	The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition.	Vitamin D	53-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-86
11983707-2	2002	Here we report that stress-activated protein kinases p38 and JNK trans-activate nuclear steroid vitamin D receptor (VDR) gene and increase vitamin D(3)-dependent growth inhibition in human breast cancer cells.	Vitamin D	96-105	vitamin D receptor	Homo sapiens	116-119
11983707-7	2002	These results establish a signaling connection between the stress MAPK pathways and steroid hormone receptor VDR expression and thereby offer new insights into regulation of cell growth by the MAPK pathways through regulation of vitamin D(3)/VDR activity.	Vitamin D	229-238	vitamin D receptor	Homo sapiens	109-112
11983707-7	2002	These results establish a signaling connection between the stress MAPK pathways and steroid hormone receptor VDR expression and thereby offer new insights into regulation of cell growth by the MAPK pathways through regulation of vitamin D(3)/VDR activity.	Vitamin D	229-238	vitamin D receptor	Homo sapiens	242-245
12174912-1	2002	BACKGROUND: The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues.	Vitamin D	225-234	vitamin D receptor	Homo sapiens	89-92
12009019-0	2002	Vitamin D analogue-specific recruitment of vitamin D receptor coactivators.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-61
11909970-5	2002	This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene.	Vitamin D	59-68	retinoid X receptor alpha	Homo sapiens	14-37
11909970-5	2002	This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene.	Vitamin D	59-68	retinoid X receptor alpha	Homo sapiens	39-42
11909970-5	2002	This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	14-17
11909970-5	2002	This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	108-111
11991436-4	2002	Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR).	Vitamin D	23-32	vitamin D receptor	Homo sapiens	81-99
11801653-3	2002	It has been established that the fat-soluble vitamin D(3) metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and its nuclear receptor, the vitamin D receptor, play an important role in the immune system primarily through the transcriptional inhibition of cytokine genes that either are required for Th1 differentiation or are products of differentiated Th1 cells.	Vitamin D	45-54	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	144-162
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	0-3
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	transforming growth factor beta 2	Homo sapiens	257-266
11743608-3	2002	VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase.	Vitamin D	99-108	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	271-295
11751074-2	2002	We wondered whether changes in Phex and neprilysin (NEP) (another member of the family of zinc endopeptidases) mRNA expression could be observed in relation to vitamin D and Pi metabolism during GH- and IGF-I-stimulated growth of hypophysectomized rats.	Vitamin D	160-169	phosphate regulating endopeptidase homolog, X-linked	Rattus norvegicus	31-35
11751074-2	2002	We wondered whether changes in Phex and neprilysin (NEP) (another member of the family of zinc endopeptidases) mRNA expression could be observed in relation to vitamin D and Pi metabolism during GH- and IGF-I-stimulated growth of hypophysectomized rats.	Vitamin D	160-169	membrane metallo-endopeptidase	Rattus norvegicus	40-50
11751074-2	2002	We wondered whether changes in Phex and neprilysin (NEP) (another member of the family of zinc endopeptidases) mRNA expression could be observed in relation to vitamin D and Pi metabolism during GH- and IGF-I-stimulated growth of hypophysectomized rats.	Vitamin D	160-169	membrane metallo-endopeptidase	Rattus norvegicus	52-55
12365798-7	2002	VDR and RXR-alpha are upregulated at the protein level in breast carcinomas as compared to normal breast tissue, indicating a possibly increased sensitivity to therapeutically applied vitamin D analogues.	Vitamin D	184-193	vitamin D receptor	Homo sapiens	0-3
12365798-7	2002	VDR and RXR-alpha are upregulated at the protein level in breast carcinomas as compared to normal breast tissue, indicating a possibly increased sensitivity to therapeutically applied vitamin D analogues.	Vitamin D	184-193	retinoid X receptor alpha	Homo sapiens	8-17
11948698-2	2002	To address these issues, milligram quantities of baculovirus-expressed hVDR were purified to 97% homogeneity, and then tested for binding to the rat osteocalcin vitamin D responsive element (VDRE) via electrophoretic mobility shift and half-site competition assays in the presence or absence of a CV-1 nuclear extract containing retinoid X receptor (RXR).	Vitamin D	161-170	vitamin D receptor	Homo sapiens	71-75
12181642-2	2002	Antiproliferative effects of vitamin D require the expression of the nuclear vitamin D receptor (VDR).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	77-95
12181642-2	2002	Antiproliferative effects of vitamin D require the expression of the nuclear vitamin D receptor (VDR).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	97-100
11689383-7	2001	The nuclear VDR has been isolated from a variety of target cells and tissues, suggesting that vitamin D compounds may have therapeutic potential throughout several body systems.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	12-15
11694617-7	2001	Treatment with vitamin D alone increased levels of matrix Gla protein, an inhibitor of soft tissue calcification, in the arteries, kidneys, lungs and trachea by 10- to 100-fold, and ibandronate treatment prevented this increase.	Vitamin D	15-24	matrix Gla protein	Rattus norvegicus	51-69
11604234-0	2001	Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells.	Vitamin D	24-33	insulin like growth factor binding protein 6	Homo sapiens	126-170
11518809-5	2001	Isoform-specific VDRB1 expression constructs produced lower ligand-dependent transactivation than VDRA when transiently transfected with a vitamin D-responsive promoter into cell lines with low endogenous VDR.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	17-20
11489753-0	2001	Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	0-18
11489753-1	2001	Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR).	Vitamin D	67-76	vitamin D receptor	Homo sapiens	175-193
11489753-1	2001	Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR).	Vitamin D	67-76	vitamin D receptor	Homo sapiens	195-198
11467853-6	2001	RT-PCR and HPLC analysis of vitamin D metabolism in primary culture cell clones strongly suggested that the extent of endogenously produced 1alpha,25-(OH)2-D3 was inversely related to 24-OHase activity, which could thus limit the antimitotic efficacy of 1alpha,25-(OH)2-D3 particularly at late stages of colon cancer progression.	Vitamin D	28-37	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	184-192
11278818-2	2001	Members of the Smad family of proteins function as effectors of TGF-beta signaling pathways whereas the vitamin D receptor (VDR) confers vitamin D signaling.	Vitamin D	104-113	vitamin D receptor	Homo sapiens	124-127
11278818-10	2001	Thus the molecular mechanism, whereby Smad3 and VDR mediate cross-talk between the TGF-beta and vitamin D signaling pathways, requires both a VDRE and a SBE located in close proximity to the target promoter.	Vitamin D	96-105	vitamin D receptor	Homo sapiens	48-51
11295155-12	2001	Further role of Vitamin D is envisaged in identifying cyclin C as an important target for Vitamin D in cell-cycle regulation.	Vitamin D	16-25	cyclin C	Homo sapiens	54-62
11295155-12	2001	Further role of Vitamin D is envisaged in identifying cyclin C as an important target for Vitamin D in cell-cycle regulation.	Vitamin D	90-99	cyclin C	Homo sapiens	54-62
11259341-8	2001	At the pharmacogenetic level, VDR alleles predict differences in gut calcium absorption and long-term bone density response to calcium intake and active vitamin D analog treatment.	Vitamin D	153-162	vitamin D receptor	Homo sapiens	30-33
11370854-4	2001	The first metabolite is probably a product of the vitamin D-inducible cytochrome P450, P450cc24 (CYP24), while the latter two metabolites are likely to be further metabolic products of 19-nor-1alpha,24,25-(OH)3D2.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	87-95
11370854-4	2001	The first metabolite is probably a product of the vitamin D-inducible cytochrome P450, P450cc24 (CYP24), while the latter two metabolites are likely to be further metabolic products of 19-nor-1alpha,24,25-(OH)3D2.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	97-102
11179725-0	2001	Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	67-85
11179728-0	2001	Central role of VDR conformations for understanding selective actions of vitamin D(3) analogues.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	16-19
11179754-0	2001	Selective inhibitors of CYP24: mechanistic tools to explore vitamin D metabolism in human keratinocytes.	Vitamin D	60-69	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	24-29
11165041-10	2001	These results indicate that CB1093 potentiates responsiveness of breast cancer cells to TNFalpha and suggest that ceramide and/or cPLA(2) might be involved as downstream effectors in vitamin D-mediated caspase-independent cell death.	Vitamin D	183-192	phospholipase A2 group IVA	Homo sapiens	130-137
11145567-1	2001	The vitamin D analog, (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647), is an antagonist of the 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] nuclear receptor (VDR)-mediated differentiation of human leukemia (HL-60) cells.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	189-192
11500934-2	2001	At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR).	Vitamin D	47-56	vitamin D receptor	Homo sapiens	76-95
11500934-2	2001	At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR).	Vitamin D	47-56	vitamin D receptor	Homo sapiens	97-100
11101387-0	2000	Synthesis of vitamin D(3) and calcitriol dimers as potential chemical inducers of vitamin D receptor dimerization.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	82-100
11050002-3	2000	Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR).	Vitamin D	87-96	vitamin D receptor	Homo sapiens	116-134
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Vitamin D	69-78	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-17
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Vitamin D	38-47	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	95-98
10828302-6	2000	Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	212-230
10828302-6	2000	Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	232-235
10828302-6	2000	Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses.	Vitamin D	29-38	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	319-343
10788778-2	2000	Most of these biological actions of vitamin D are now considered to be exerted through the nuclear vitamin D receptor (VDR)-mediated control of target genes.	Vitamin D	36-45	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	99-117
10788778-2	2000	Most of these biological actions of vitamin D are now considered to be exerted through the nuclear vitamin D receptor (VDR)-mediated control of target genes.	Vitamin D	36-45	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	119-122
10788778-5	2000	The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.	Vitamin D	203-212	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
10788778-5	2000	The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.	Vitamin D	203-212	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
10788778-5	2000	The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.	Vitamin D	203-212	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
10788778-5	2000	The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.	Vitamin D	371-380	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
10788778-5	2000	The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.	Vitamin D	371-380	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
10788778-5	2000	The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.	Vitamin D	371-380	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	97-100
10751640-5	2000	Furthermore, we found that the C-3 epimerization acts as one of the important pathways in vitamin D metabolism.	Vitamin D	90-99	complement C3	Rattus norvegicus	31-34
10762752-9	2000	Since the cell differentiating effect of vitamin D is considered to be mediated via the vitamin D receptor (VDR), we examined the induction of VDR using reverse transcriptase-polymerase chain reaction (RT-PCR) in both cells.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	88-106
10762752-9	2000	Since the cell differentiating effect of vitamin D is considered to be mediated via the vitamin D receptor (VDR), we examined the induction of VDR using reverse transcriptase-polymerase chain reaction (RT-PCR) in both cells.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	108-111
10797570-1	2000	1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	146-164
10797570-1	2000	1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	166-169
10797570-1	2000	1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	171-176
10797570-2	2000	Vitamin D receptor can directly regulate gene expression by binding to vitamin D response elements (VDREs) located in promoter or enhancer regions of various genes.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	0-18
10775803-1	2000	Interference footprinting protocols were utilized to examine the interactions of the vitamin D receptor (VDR) with either a positive or a negative vitamin D response element (VDRE).	Vitamin D	85-94	vitamin D receptor	Homo sapiens	105-108
10642439-3	2000	An increase in plasma calcium, achieved by repletion of vitamin D-deficient chicks with a normal diet, by PTH injection, or during eggshell formation, increased the expression of the CaR gene.	Vitamin D	56-65	calcium sensing receptor	Gallus gallus	183-186
10642439-4	2000	Low plasma calcium concentration in vitamin D-deficient chicks or in layers, before or after eggshell formation, was associated with decrease in CaR gene expression in the PG.	Vitamin D	36-45	calcium sensing receptor	Gallus gallus	145-148
10687851-2	2000	A human VDR expression plasmid was transfected into HeLa, Saos-2 and MG63 cells with a luciferase reporter gene construct containing the vitamin D responsive element.	Vitamin D	137-146	vitamin D receptor	Homo sapiens	8-11
10620374-2	2000	In the present investigation we probed the vitamin D sterol-binding pocket of human DBP with affinity labeling analogs of 25-hydroxyvitamin D(3) ?25-OH-D(3) and 1, 25-dihydroxyvitamin D(3) ?1,25(OH)(2)D(3) containing bromoacetate alkylating probe at C-3 (A-ring), C-6 (triene), C-11 (C-ring), and C-19 (exocyclic methylene) of the parent sterol.	Vitamin D	43-52	complement C3	Homo sapiens	250-253
10620374-2	2000	In the present investigation we probed the vitamin D sterol-binding pocket of human DBP with affinity labeling analogs of 25-hydroxyvitamin D(3) ?25-OH-D(3) and 1, 25-dihydroxyvitamin D(3) ?1,25(OH)(2)D(3) containing bromoacetate alkylating probe at C-3 (A-ring), C-6 (triene), C-11 (C-ring), and C-19 (exocyclic methylene) of the parent sterol.	Vitamin D	43-52	aldo-keto reductase family 1 member C4	Homo sapiens	278-282
10731641-5	2000	The induction of mRNA for ckb in ROS 17/2.8 cells by E(2) or SERMS was demonstrated only after vitamin D pretreatment; there was no inhibition of E(2) induction by SERMS.	Vitamin D	95-104	creatine kinase B	Rattus norvegicus	26-29
10678179-2	2000	We report the 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D.	Vitamin D	178-187	vitamin D receptor	Homo sapiens	74-77
11073270-14	2000	In a series of elegant experiments [9,10], calcitriol resistance has been related to disturbed genomic effects of active vitamin D because the interaction of the vitamin D receptor ligand complex with vitamin D-responsive elements (VDREs) upstream of vitamin D-regulated genes was disturbed by the action of low molecular weight substances in uraemia, which have not been completely characterized.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	162-180
10640889-0	1999	Effect of vitamin D(3) treatment in the neonatal or adolescent age (hormonal imprinting) on the thymic glucocorticoid receptor of the adult male rat.	Vitamin D	10-19	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	103-126
10640889-1	1999	Single neonatal treatment with 25 microg vitamin D(3) significantly decreased the thymic glucocorticoid receptor density (B(max)) of 6-week-old male rats.	Vitamin D	41-50	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	89-112
10640889-3	1999	Single vitamin D(3) treatment (50 microg) during adolescence (i.e. 6-week-old animals) significantly increased the glucocorticoid receptor density in adult (10-week-old) males.	Vitamin D	7-16	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	115-138
10536369-2	1999	However, it was reported [Schrader et al., 1994] that, on putative vitamin D response elements (VDREs) within the rat 9k and mouse 28k calcium binding protein genes (rCaBP 9k and mCaBP 28k), VDR and thyroid hormone receptor (TR) form heterodimers that transactivate in response to both 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and triiodothyronine (T(3)).	Vitamin D	67-76	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	96-99
10612418-2	1999	An active form of vitamin D, 1alpha,25(OH)2D3, serves as a vitamin D receptor (VDR)-specific ligand to activate the expression of a particular set of target genes.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	59-77
10612418-2	1999	An active form of vitamin D, 1alpha,25(OH)2D3, serves as a vitamin D receptor (VDR)-specific ligand to activate the expression of a particular set of target genes.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	79-82
10496974-6	1999	Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	90-93
10496974-6	1999	Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	148-151
10496974-6	1999	Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	148-151
10510471-0	1999	Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2.	Vitamin D	16-25	phospholipase A2 group IVA	Homo sapiens	125-151
10510471-9	1999	These results suggest that TNFalpha and vitamin D analogs share a common pathway leading to apoptosis involving cPLA2 activation and/or ceramide generation.	Vitamin D	40-49	phospholipase A2 group IVA	Homo sapiens	112-117
10427145-5	1999	We report here that the vitamin D analogue EB1089 interferes with the IGF-IR signaling pathway by attenuating IGF-I-induced tyrosine phosphorylation of IRS-1, and to a lesser extent, IRS-2.	Vitamin D	24-33	insulin like growth factor 1 receptor	Homo sapiens	70-76
10406465-3	1999	We have analyzed the role of GHF-1 and of the vitamin D receptor (VDR) to confer vitamin D responsiveness to the PRL promoter.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	66-69
10406465-8	1999	Truncation of the last 12 C-terminal amino acids of VDR, which contain the ligand-dependent activation function (AF2), abolishes regulation by vitamin D, suggesting that binding of coactivators to this region mediates ligand-dependent stimulation of the PRL promoter by the receptor.	Vitamin D	143-152	vitamin D receptor	Homo sapiens	52-55
10406465-9	1999	Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor.	Vitamin D	168-177	vitamin D receptor	Homo sapiens	204-207
10224118-6	1999	As a consequence, overexpression of steroid receptor coactivator-1 increased vitamin D-dependent transactivation by VDR but not by the K246A mutant.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	116-119
10322128-0	1999	Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3.	Vitamin D	23-32	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	46-49
10100926-11	1999	The findings are in line with the idea that the gastrin-ECL-cell axis can be suppressed by vitamin D or by vitamin D-dependent mechanisms.	Vitamin D	91-100	gastrin	Rattus norvegicus	48-55
10100926-11	1999	The findings are in line with the idea that the gastrin-ECL-cell axis can be suppressed by vitamin D or by vitamin D-dependent mechanisms.	Vitamin D	107-116	gastrin	Rattus norvegicus	48-55
9891040-3	1999	We examined interaction of VDR with these coactivators that was induced by several vitamin D analogs, since they exert differential subsets of the biological action of vitamin D through unknown mechanisms.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	27-30
9891040-3	1999	We examined interaction of VDR with these coactivators that was induced by several vitamin D analogs, since they exert differential subsets of the biological action of vitamin D through unknown mechanisms.	Vitamin D	168-177	vitamin D receptor	Homo sapiens	27-30
9891040-6	1999	Thus, the present findings suggest that the structure of VDR is altered in a vitamin D analog-specific way, resulting in selective interactions of VDR with coactivators.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	57-60
9891040-6	1999	Thus, the present findings suggest that the structure of VDR is altered in a vitamin D analog-specific way, resulting in selective interactions of VDR with coactivators.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	147-150
9891040-7	1999	Such selective interaction of coactivators with VDR may specify the array of biological actions of a vitamin D analog like OCT, possibly through activating a particular set of target gene promoters.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	48-51
10609868-1	1999	Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR).	Vitamin D	24-33	vitamin D receptor	Homo sapiens	286-304
10609868-1	1999	Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR).	Vitamin D	24-33	vitamin D receptor	Homo sapiens	306-309
9892040-1	1998	The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	246-264
9892040-1	1998	The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	266-269
9753621-1	1998	Previous studies have shown that the binding affinity of a vitamin D analogue for the vitamin D receptor (VDR) does not correlate with the biological potency of the compound.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	86-104
9753621-1	1998	Previous studies have shown that the binding affinity of a vitamin D analogue for the vitamin D receptor (VDR) does not correlate with the biological potency of the compound.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	106-109
9753621-2	1998	In the present investigation the vitamin D analogue GS 1500, which is characterised by an altered stereochemistry at carbon C-20 (20-epi) and an aromatic ring in the side chain, was studied with respect to its interaction with the VDR.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	231-234
9753621-5	1998	At the level of VDR interaction with the vitamin D responsive element, GS 1500 did induce a binding complex at a lower concentration than 1,25(OH)2D3, which may help explain the difference in potency.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	16-19
9690035-2	1998	An active form of vitamin D acting as a ligand specific vitamin D receptor (VDR), 1 alpha,25(OH)2D3, is biosynthesized from cholesterol, and during this biosynthesis a renal 25-hydroxylation at the final stage by 25-hydroxyvitamin D3 1 alpha-hydroxylase is critical.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	56-74
9690035-2	1998	An active form of vitamin D acting as a ligand specific vitamin D receptor (VDR), 1 alpha,25(OH)2D3, is biosynthesized from cholesterol, and during this biosynthesis a renal 25-hydroxylation at the final stage by 25-hydroxyvitamin D3 1 alpha-hydroxylase is critical.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	76-79
9624222-13	1998	Variation in vitamin D requirements could arise from genetic differences in vitamin D processing since bone density can vary with vitamin D-receptor genotype.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	130-148
9624222-13	1998	Variation in vitamin D requirements could arise from genetic differences in vitamin D processing since bone density can vary with vitamin D-receptor genotype.	Vitamin D	76-85	vitamin D receptor	Homo sapiens	130-148
9543154-7	1998	These data suggest that IDBP is relatively specific for 25OHD3 and that additional hsp-70-like binding proteins are present in unpurified New World primate cell extracts that are specific for 1-hydroxylated vitamin D metabolites as well as other gonadal steroid hormones.	Vitamin D	207-216	heat shock protein family A (Hsp70) member 4	Homo sapiens	83-89
9586948-1	1998	The biological active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates most of its actions through the intracellular vitamin D receptor (VDR).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	136-154
9586948-1	1998	The biological active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates most of its actions through the intracellular vitamin D receptor (VDR).	Vitamin D	30-39	vitamin D receptor	Homo sapiens	156-159
9586948-2	1998	VDR binds to vitamin D responsive elements (VDREs) in the promoter region of responsive genes and regulates transcription.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	0-3
9528006-1	1998	The vitamin D receptor (VDR) binds to specific DNA sequences termed vitamin D response elements (VDREs) thereby enhancing or repressing transcription.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
9495519-1	1998	Mutations in the vitamin D receptor (VDR) gene have been shown to cause hereditary vitamin D-resistant rickets (HVDRR).	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
9597143-8	1998	The active form of vitamin D has immunomodulatory effects, and allelic variants of the vitamin D receptor appear to be associated with differential susceptibility to several infectious diseases.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	87-105
9431991-5	1997	However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	205-223
9431991-5	1997	However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	225-228
9265628-6	1997	Gel mobility shift analyses of the VDR DBD with several vitamin D response elements (VDREs) in the absence of accessory proteins such as retinoic acid receptor, showed that VDR DBD was able to form a protein/VDRE DNA structural complex.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	35-38
9265628-6	1997	Gel mobility shift analyses of the VDR DBD with several vitamin D response elements (VDREs) in the absence of accessory proteins such as retinoic acid receptor, showed that VDR DBD was able to form a protein/VDRE DNA structural complex.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	85-88
9258754-0	1997	The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	107-125
9258754-10	1997	The VDR genotype-dependent effect of vitamin D supplementation in these elderly subjects suggest a functional involvement of VDR gene variants in determining BMD.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	4-7
9258754-10	1997	The VDR genotype-dependent effect of vitamin D supplementation in these elderly subjects suggest a functional involvement of VDR gene variants in determining BMD.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	125-128
9241280-1	1997	1 alpha,25-Dihydroxyvitamin D3[1 alpha,25(OH)2D3], an active form of vitamin D, has roles in many biological phenomena such as calcium homeostasis and bone formation, which are thought to be mediated by the 1 alpha,25(OH)2D3 receptor (VDR), a member of the nuclear hormone receptor superfamily.	Vitamin D	20-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	235-238
9204985-5	1997	Fluorescence activated cell scanning (FACS) analyses indicated that the vitamin D derivatives readily induced the expression of the monocyte-associated cell surface antigen, CD14, and also the beta2-integrins, CD11b and CD18 in both cell lines after 48 h and 96 h treatment.	Vitamin D	72-81	integrin subunit alpha M	Homo sapiens	210-215
9204985-7	1997	When U937 and HL-60 cell cultures were cotreated for 48 h with the vitamin D compounds and GM-CSF and analysed by FACS, enhanced effects on CD14 and CD11b induction were observed compared to those of the compounds alone.	Vitamin D	67-76	integrin subunit alpha M	Homo sapiens	149-154
9204985-8	1997	These co-operative effects may occur as a consequence of molecular events which involve the transcription by vitamin D receptors (VDR) of genes required for the responsiveness of immature cells to factors such as GM-CSF, and place these and other related vitamin D analogues as potential therapeutic agents in the treatment of leukaemia.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	130-133
9200691-1	1997	1alpha,25-Dihydroxyvitamin D3, the vitamin D hormone, manifests its diverse biological properties by specifically binding to the vitamin D sterol-binding pockets of vitamin D-binding protein (DBP) and vitamin D receptor.	Vitamin D	19-28	GC vitamin D binding protein	Homo sapiens	165-190
9200691-1	1997	1alpha,25-Dihydroxyvitamin D3, the vitamin D hormone, manifests its diverse biological properties by specifically binding to the vitamin D sterol-binding pockets of vitamin D-binding protein (DBP) and vitamin D receptor.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	201-219
9165021-6	1997	The xVDR polypeptide can heterodimerize with the mouse retinoid X receptor alpha, bind to the rat osteocalcin vitamin D response element (VDRE), and induce vitamin D-dependent transactivation in transfected mammalian cells.	Vitamin D	110-119	vitamin D receptor S homeolog	Xenopus laevis	4-8
9165021-6	1997	The xVDR polypeptide can heterodimerize with the mouse retinoid X receptor alpha, bind to the rat osteocalcin vitamin D response element (VDRE), and induce vitamin D-dependent transactivation in transfected mammalian cells.	Vitamin D	156-165	vitamin D receptor S homeolog	Xenopus laevis	4-8
9169350-6	1997	The extent of vitamin D-dependent transcriptional activation of a reporter construct under the control of a vitamin D response element in transfected HeLa cells was approximately 1.7-fold greater for the m type VDR than for the M type protein.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	211-214
9169350-6	1997	The extent of vitamin D-dependent transcriptional activation of a reporter construct under the control of a vitamin D response element in transfected HeLa cells was approximately 1.7-fold greater for the m type VDR than for the M type protein.	Vitamin D	108-117	vitamin D receptor	Homo sapiens	211-214
9013769-2	1997	However, the functional relevance of the VDR-TFIIB interaction in vitamin D-mediated transcription is not well understood.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	41-44
9013769-5	1997	This N-terminal, VDR-interactive domain functioned as a selective, dominant-negative inhibitor of vitamin D-mediated transcription.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	17-20
9013769-9	1997	Mechanistically, these data establish a functional role for the N terminus of TFIIB in VDR-mediated transcription, and they allude to a role for unliganded VDR in targeting TFIIB to the promoter regions of vitamin D-responsive target genes.	Vitamin D	206-215	vitamin D receptor	Homo sapiens	87-90
9013769-9	1997	Mechanistically, these data establish a functional role for the N terminus of TFIIB in VDR-mediated transcription, and they allude to a role for unliganded VDR in targeting TFIIB to the promoter regions of vitamin D-responsive target genes.	Vitamin D	206-215	vitamin D receptor	Homo sapiens	156-159
9005998-0	1997	Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	73-91
9005998-1	1997	Mutations in the vitamin D receptor (VDR) result in target organ resistance to 1alpha,25-dihydroxyvitamin D [1,25(OH)2D3], the active form of vitamin D, and cause hereditary 1,25-dihydroxyvitamin D resistant rickets (HVDRR).	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
8990171-9	1997	Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	147-150
9117516-8	1997	Induction of the receptor for the anti-inflammatory cytokine IL-10 may be involved in the antipsoriatic action of vitamin D derivatives.	Vitamin D	114-123	interleukin 10 receptor subunit alpha	Homo sapiens	61-66
8841046-10	1996	Analysis of VDR alleles may prove useful in selecting the vitamin D therapy for osteopenia before treatment.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	12-15
8709103-1	1996	Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP).	Vitamin D	55-64	vitamin D receptor	Homo sapiens	114-132
8709103-1	1996	Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP).	Vitamin D	55-64	vitamin D receptor	Homo sapiens	134-137
8709103-1	1996	Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP).	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	166-191
8681462-1	1996	The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	275-293
8681462-1	1996	The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	295-298
8726384-1	1996	The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D3 (1,25D), are mediated via the vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	106-124
8726384-1	1996	The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D3 (1,25D), are mediated via the vitamin D receptor (VDR).	Vitamin D	40-49	vitamin D receptor	Homo sapiens	126-129
9627686-7	1996	Because RXR heterodimerizes with either RARs or VDR, it functions as a key protein in the overall retinoid or vitamin D response of a given biological system.	Vitamin D	110-119	retinoid X receptor alpha	Homo sapiens	8-11
9627686-7	1996	Because RXR heterodimerizes with either RARs or VDR, it functions as a key protein in the overall retinoid or vitamin D response of a given biological system.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	48-51
9627691-0	1996	The anti-proliferative and differentiation-inducing effects of vitamin D analogs are not determined by the binding affinity for the vitamin D receptor alone.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	132-150
8780248-8	1996	PTG CaR peaked at 16 h (150% of control, P &lt; 0.05) after 1,25-(OH)2D3 administration but returned to normal by 24 h. This upregulation of CaR expression by 1,25-(OH)2D3 may be involved in the suppressive effects of vitamin D compounds on PTH secretion.	Vitamin D	218-227	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	4-7
8780248-8	1996	PTG CaR peaked at 16 h (150% of control, P &lt; 0.05) after 1,25-(OH)2D3 administration but returned to normal by 24 h. This upregulation of CaR expression by 1,25-(OH)2D3 may be involved in the suppressive effects of vitamin D compounds on PTH secretion.	Vitamin D	218-227	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	141-144
8622645-6	1996	Although VDR can bind as a homodimer to the osteopontin gene vitamin D response element, we find that a RXR-VDR heterodimer must be the transactivating species from the element in vivo, since RXR enhances and 9-cis RA and other RXR-specific ligands attenuate this induction.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	9-12
8593831-7	1996	In addition, vitamin D-resistant cell nuclear extract contained a protein(s) which was bound specifically to the VDRE and was capable of completely inhibiting VDR-RXR-VDRE complex formation; these effects were not demonstrated with nuclear extract from the wild type cell line or with the post-nuclear extract of the vitamin D-resistant cell line.	Vitamin D	317-326	retinoid X receptor alpha	Homo sapiens	163-166
8593831-8	1996	We conclude that a VDRE-binding protein(s), distinct from IDBP and present in nuclear extract of cells from a prototypical vitamin D-resistant NWP, is capable of inhibiting normal VDR-RXR heterodimer binding to the VDRE.	Vitamin D	123-132	vitamin D receptor	Homo sapiens	19-22
8593831-8	1996	We conclude that a VDRE-binding protein(s), distinct from IDBP and present in nuclear extract of cells from a prototypical vitamin D-resistant NWP, is capable of inhibiting normal VDR-RXR heterodimer binding to the VDRE.	Vitamin D	123-132	retinoid X receptor alpha	Homo sapiens	184-187
8858258-1	1996	In addition to a role in calcium and phosphate homeostasis other vitamin D receptor (VDR) mediated effects have been discovered during the past few years for the biologically active metabolite of vitamin D, 1,25(OH)2D3.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	85-88
8650307-7	1996	Advances in our understanding of the vitamin D mechanism of action can clearly be expected from physical studies of cloned and expressed vitamin D receptor and its subdomains, elucidation of the transcription factors in vitamin D-modulated transcription of target genes, elucidation of the role of phosphorylation in the transcription process, and the identification of important genes that are regulated in the specific target tissues responsive to vitamin D.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	137-155
21597875-3	1995	The affinity of vitamin D analogs for vitamin D receptor relative to 125(OH)(2)-vitamin D-3 was determined with a hydroxyapatite-based competitive binding assay.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	38-56
21597875-6	1995	Competitive binding of the vitamin D analogs to vitamin D receptor ranged from 51% to 72% that of 1,25(OH)(2)-vitamin D-3, suggesting a receptor-mediated response.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	48-66
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	51-54
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	105-108
7650055-4	1995	The gel shift assay showed the vitamin D receptor (VDR) complex binding to vitamin D responsive element (VDRE) was inhibited under constitutively expressed c-fos gene, suggesting that c-fos gene product, c-Fos, may inhibit the binding of VDR complex to VDRE by making a c-Fos-VDR complex.	Vitamin D	31-40	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	105-108
7491109-4	1995	Initial screening of these mutants indicated that all were significantly impaired in their ability to activate transcription from a vitamin D-responsive reporter construct when expressed in transfected VDR-deficient COS-7 cells.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	202-205
7566512-1	1995	The regulation of cholecystokinin and somatostatin expression by vitamin D and cyclic AMP in the rat medullary thyroid carcinoma cell line CA-77 was investigated.	Vitamin D	65-74	cholecystokinin	Rattus norvegicus	18-33
7738187-9	1995	In vitamin D deficiency, there were no alterations in colonic PKC isoform expression but significant changes in the subcellular distribution of PKC-alpha, -delta, and -zeta.	Vitamin D	3-12	protein kinase C, alpha	Rattus norvegicus	144-172
7738187-11	1995	The alterations in PKC isoform distribution and PKC-alpha responsiveness to 1,25(OH)2D3 in vitamin D deficiency were partially, but significantly, restored with 5-7 d in vivo repletion of this secosteroid.	Vitamin D	91-100	protein kinase C, alpha	Rattus norvegicus	19-22
7738187-11	1995	The alterations in PKC isoform distribution and PKC-alpha responsiveness to 1,25(OH)2D3 in vitamin D deficiency were partially, but significantly, restored with 5-7 d in vivo repletion of this secosteroid.	Vitamin D	91-100	protein kinase C, alpha	Rattus norvegicus	48-57
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	50-70
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	72-75
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	4-22
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	24-27
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	85-94	retinoid X receptor alpha	Homo sapiens	50-70
7876247-1	1995	The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription.	Vitamin D	85-94	retinoid X receptor alpha	Homo sapiens	72-75
7899080-1	1995	The vitamin D receptor mediates the signal of 1 alpha, 25-dihydroxyvitamin D3 by binding to vitamin D responsive elements in DNA as a homodimer or as a heterodimer composed of one vitamin D receptor subunit and one retinoid X receptor subunit.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	180-198
7899080-1	1995	The vitamin D receptor mediates the signal of 1 alpha, 25-dihydroxyvitamin D3 by binding to vitamin D responsive elements in DNA as a homodimer or as a heterodimer composed of one vitamin D receptor subunit and one retinoid X receptor subunit.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	215-234
7822428-10	1995	In contrast to our findings in colonocytes from vitamin D-sufficient animals, basal phosphorylation of pp42 and pp48 were increased in membranes prepared from vitamin D-insufficient rats.	Vitamin D	159-168	eukaryotic translation initiation factor 2 subunit gamma	Rattus norvegicus	103-107
7980557-0	1994	Organization and expression of the mouse spot35/calbindin-D28k gene: identification of the vitamin D-responsive promoter region.	Vitamin D	91-100	calbindin 1	Mus musculus	48-62
7980557-6	1994	In conclusion, the proximal direct repeat plays a critical role in mediating the vitamin D-induced expression of calbindin-D28k in the kidney.	Vitamin D	81-90	calbindin 1	Mus musculus	113-127
7917316-1	1994	An expanded role for vitamin D (1 alpha,25-(OH)2D3) in mammalian systems has been suggested by recent evidence that its receptor (vitamin D receptor [VDR]) is present not only in classical target organs, but in a variety of normal tissues and organs, tumor tissues, and cancer cell lines.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	130-148
7917316-1	1994	An expanded role for vitamin D (1 alpha,25-(OH)2D3) in mammalian systems has been suggested by recent evidence that its receptor (vitamin D receptor [VDR]) is present not only in classical target organs, but in a variety of normal tissues and organs, tumor tissues, and cancer cell lines.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	150-153
8089197-4	1994	Formation of both complexes is Vitamin D dependent and they contain the Vitamin D receptor as well as an RXR related protein.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	72-90
8089197-4	1994	Formation of both complexes is Vitamin D dependent and they contain the Vitamin D receptor as well as an RXR related protein.	Vitamin D	31-40	retinoid X receptor alpha	Homo sapiens	105-108
8089197-8	1994	Our findings suggest variations in protein/protein and protein/DNA interactions of the VDR and RXR related complexes V1 and V2 at the osteocalcin Vitamin D responsive element that reflect unique properties of the osteosarcoma and normal diploid osteoblast phenotype.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	87-90
8089197-8	1994	Our findings suggest variations in protein/protein and protein/DNA interactions of the VDR and RXR related complexes V1 and V2 at the osteocalcin Vitamin D responsive element that reflect unique properties of the osteosarcoma and normal diploid osteoblast phenotype.	Vitamin D	146-155	retinoid X receptor alpha	Homo sapiens	95-98
32717927-4	2020	A high concentration of active vitamin D, 1alpha,25(OH)2D3, decreased the expression of myogenic regulatory factors (MRFs), myf5 and myogenin in proliferating myoblasts.	Vitamin D	31-40	myogenin	Homo sapiens	133-141
32717927-5	2020	In addition, high concentration of vitamin D reduced myoblast-to-myoblast and myoblast-to-myotube fusion through the inhibition of Tmem8c (myomaker) and Gm7325 (myomerger), which encode muscle-specific fusion-related micropeptides.	Vitamin D	35-44	myomaker, myoblast fusion factor	Homo sapiens	131-137
32679840-2	2020	In this study, we evaluated whether treatment with the vitamin D analogue, calcipotriol, counterbalances PDAC induced and SMAD4-associated intracellular calcium [Ca2+]i alterations, cytokines release, immune effector function, and the intracellular signaling of peripheral blood mononuclear cells (PBMCs).	Vitamin D	55-64	SMAD family member 4	Homo sapiens	122-127
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Vitamin D	146-155	angiotensin converting enzyme 2	Homo sapiens	72-76
32164458-0	2020	Assessing vitamin D levels in an anti-DFS70 positive population: New insights emerging.	Vitamin D	10-19	PC4 and SFRS1 interacting protein 1	Homo sapiens	38-43
32164458-4	2020	No statistically relevant differences in BMI, clinical, or demographic parameters were found.Conclusions: Our findings showed higher levels of vitamin D in anti-DFS70 positive subjects than in the controls, which is compatible with the hypothesis of the "benign" nature of anti-DFS70 antibodies.	Vitamin D	143-152	PC4 and SFRS1 interacting protein 1	Homo sapiens	161-166
32164458-4	2020	No statistically relevant differences in BMI, clinical, or demographic parameters were found.Conclusions: Our findings showed higher levels of vitamin D in anti-DFS70 positive subjects than in the controls, which is compatible with the hypothesis of the "benign" nature of anti-DFS70 antibodies.	Vitamin D	143-152	PC4 and SFRS1 interacting protein 1	Homo sapiens	278-283
32235811-7	2020	Additionally, protein expression of VE-cadherin was increased and fibroblast-specific protein-1 (FSP1) was decreased after vitamin D treatment in the ISO-induced fibrosis rat.	Vitamin D	123-132	cadherin 5	Rattus norvegicus	36-47
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	67-76	LDL receptor related protein 2	Homo sapiens	0-7
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	188-197	LDL receptor related protein 2	Homo sapiens	0-7
32138242-3	2020	In Mcoln1-/- mice, we found that a high dose of vitamin D (Vit D; 500,000 IU/kg/day) resulted in increased AMC compared to their wild-type littermates, which was accompanied by significant downregulation of SM22-alpha and upregulation of RUNX2 and osteopontin in the arterial media, indicating a phenotypic switch to osteogenic.	Vitamin D	48-57	secreted phosphoprotein 1	Mus musculus	248-259
32184917-8	2020	Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1.	Vitamin D	29-38	cytochrome b-245, beta polypeptide	Mus musculus	187-195
32158346-9	2020	There was a significant relationship between JAK2 positivity and vitamin D deficiency.	Vitamin D	65-74	Janus kinase 2	Homo sapiens	45-49
32158346-10	2020	Conclusion: There was a remarkably higher prevalence of vitamin D deficiency in JAK2 mutation-positive ET and PV patients.	Vitamin D	56-65	Janus kinase 2	Homo sapiens	80-84
32158346-12	2020	More studies are required to further investigate the association between JAK2 and vitamin D.	Vitamin D	82-91	Janus kinase 2	Homo sapiens	73-77
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	microsomal triglyceride transfer protein	Mus musculus	155-159
32918223-11	2020	Other targets for vitamin D compounds include 1,25D3-MARRS, retinoic orphan receptors alpha and gamma, aryl hydrocarbon receptor, and Wnt signaling.	Vitamin D	18-27	aryl hydrocarbon receptor	Homo sapiens	103-128
32348981-2	2020	Recently in vitro data have suggested vitamin D may play a role in stabilizing CCM2 endothelial cells.	Vitamin D	38-47	CCM2 scaffold protein	Homo sapiens	79-83
32238143-7	2020	The immunmodulatory effects of the active metabolite of vitamin D (alpha-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-beta and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC.	Vitamin D	56-65	transforming growth factor alpha	Homo sapiens	123-131
32238143-9	2020	RESULTS: Severe vitamin D deficiency was registered in Algerian MetS patients, the deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity.	Vitamin D	16-25	matrix metallopeptidase 2	Homo sapiens	169-173
32001956-2	2020	Here, we investigated the association between Cyp24a1, a vitamin D catabolic enzyme, and abnormalities in vitamin D metabolism in streptozotocin-induced diabetes rats, an animal model of type 1 diabetes.	Vitamin D	57-66	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	46-53
32001956-2	2020	Here, we investigated the association between Cyp24a1, a vitamin D catabolic enzyme, and abnormalities in vitamin D metabolism in streptozotocin-induced diabetes rats, an animal model of type 1 diabetes.	Vitamin D	106-115	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	46-53
32155001-5	2020	The close relationship between vitamin D(OH) concentration and brain natriuretic peptide (BNP) levels was characterized by rs=0.187 (p=0.007).	Vitamin D	31-40	natriuretic peptide B	Homo sapiens	63-88
32155001-5	2020	The close relationship between vitamin D(OH) concentration and brain natriuretic peptide (BNP) levels was characterized by rs=0.187 (p=0.007).	Vitamin D	31-40	natriuretic peptide B	Homo sapiens	90-93
31812959-8	2020	RESULTS: The vitamin D concentration positively affected the concentration of NRG1 (F = 8.583, p = 0.005) but not the concentration of other investigated growth factors (BDNF and NGF).	Vitamin D	13-22	neuregulin 1	Homo sapiens	78-82
31812959-10	2020	CONCLUSION: The vitamin D concentration positively affected NRG1 levels but not schizophrenia symptomatology as measured by PANSS.	Vitamin D	16-25	neuregulin 1	Homo sapiens	60-64
33601398-0	2020	Vitamin D Alleviates Cognitive Dysfunction by Activating the VDR/ERK1/2 Signaling Pathway in an Alzheimer"s Disease Mouse Model.	Vitamin D	0-9	mitogen-activated protein kinase 3	Mus musculus	65-71
32961447-1	2020	OBJECTIVES: Renal phosphate and vitamin D metabolism are regulated by proteohormone fibroblast growth factor 23 (FGF23), which is secreted by bone cells.	Vitamin D	32-41	fibroblast growth factor 23	Rattus norvegicus	84-111
32961447-1	2020	OBJECTIVES: Renal phosphate and vitamin D metabolism are regulated by proteohormone fibroblast growth factor 23 (FGF23), which is secreted by bone cells.	Vitamin D	32-41	fibroblast growth factor 23	Rattus norvegicus	113-118
32961447-2	2020	FGF23 inhibits phosphate reabsorption and the production of calcitriol, active vitamin D (1,25(OH)2D3).	Vitamin D	79-88	fibroblast growth factor 23	Rattus norvegicus	0-5
33169107-5	2020	Vitamin D is known to enhance the rate of melanin synthesis; and this may concurrently regulate the expression of furin expression.	Vitamin D	0-9	furin, paired basic amino acid cleaving enzyme	Homo sapiens	114-119
33169107-7	2020	On the other hand, furin expression is negatively regulated via 1-alpha-hydroxylase (CYP27B1), that belongs to vitamin-D pathway and controls cellular calcium levels.	Vitamin D	111-120	furin, paired basic amino acid cleaving enzyme	Homo sapiens	19-24
33169107-9	2020	Thus, we propose a possible synergistic application of melanin and the enzyme CYP27B1 (regulates vitamin D biosynthesis) as a novel strategy to prevent viral entry through the inactivation of furin protease and aid in boosting our immunity at the cellular and humoral levels.	Vitamin D	97-106	furin, paired basic amino acid cleaving enzyme	Homo sapiens	192-197
33169107-9	2020	Thus, we propose a possible synergistic application of melanin and the enzyme CYP27B1 (regulates vitamin D biosynthesis) as a novel strategy to prevent viral entry through the inactivation of furin protease and aid in boosting our immunity at the cellular and humoral levels.	Vitamin D	97-106	activation induced cytidine deaminase	Homo sapiens	211-214
31618573-2	2019	In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity.	Vitamin D	68-77	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	140-145
31618573-3	2019	These synthetic vitamin D probes permitted identification of one of the vitamin D-responsive genes, Soat1, as an SREBP-suppressed gene.	Vitamin D	16-25	sterol O-acyltransferase 1	Homo sapiens	100-105
31618573-3	2019	These synthetic vitamin D probes permitted identification of one of the vitamin D-responsive genes, Soat1, as an SREBP-suppressed gene.	Vitamin D	16-25	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	113-118
31618573-3	2019	These synthetic vitamin D probes permitted identification of one of the vitamin D-responsive genes, Soat1, as an SREBP-suppressed gene.	Vitamin D	72-81	sterol O-acyltransferase 1	Homo sapiens	100-105
31618573-3	2019	These synthetic vitamin D probes permitted identification of one of the vitamin D-responsive genes, Soat1, as an SREBP-suppressed gene.	Vitamin D	72-81	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	113-118
31823791-0	2019	OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D.	Vitamin D	99-108	TNF receptor superfamily member 11b	Homo sapiens	0-3
31823791-0	2019	OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D.	Vitamin D	99-108	TNF receptor superfamily member 11a	Homo sapiens	4-8
31201665-3	2019	Fibroblast growth factor 23 (FGF23) is produced by bone cells, and regulates renal phosphate and vitamin D metabolism as a hormone.	Vitamin D	97-106	fibroblast growth factor 23	Rattus norvegicus	0-27
31201665-3	2019	Fibroblast growth factor 23 (FGF23) is produced by bone cells, and regulates renal phosphate and vitamin D metabolism as a hormone.	Vitamin D	97-106	fibroblast growth factor 23	Rattus norvegicus	29-34
30806610-0	2019	Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?	Vitamin D	43-52	chitinase 3 like 1	Homo sapiens	4-10
30806610-3	2019	In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency.	Vitamin D	117-126	chitinase 3 like 1	Homo sapiens	88-94
30806610-12	2019	Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.	Vitamin D	0-9	chitinase 3 like 1	Homo sapiens	44-50
30829137-1	2019	The present randomized, double-blind, placebo controlled study aimed to evaluate the effect of vitamin D supplementation on matrix metalloproteinases-2, -9 (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in subjects with metabolic syndrome.	Vitamin D	95-104	matrix metallopeptidase 2	Homo sapiens	157-162
31317663-0	2019	Isoflavones rich cowpea and vitamin D induces the proliferation and differentiation of human osteoblasts via BMP-2/Smad pathway activation: Mechanistic approach.	Vitamin D	28-37	bone morphogenetic protein 2	Homo sapiens	109-114
31439681-3	2019	In VDAART, in the GG genotype vitamin D supplementation was associated with increased plasma levels of sphingolipids, including sphingosine-1-phosphate (beta 0.022, 95% CI 0.001-0.044, p=0.038), but this was not evident with the CC genotype, known to be associated with increased expression of ORMDL3 in bronchial epithelial cells.	Vitamin D	30-39	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	294-300
31439681-5	2019	In a cellular model, there was a significant difference in the induction of sphingosine-1-phosphate by vitamin D between a control human bronchial epithelial cell line and a cell line overexpressing ORMDL3 (p=0.002).Results suggest prenatal vitamin D supplementation may reduce the risk of early childhood asthma/wheeze via alterations of sphingolipid metabolism dependent on the 17q21 genotype.	Vitamin D	103-112	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	199-205
31439681-5	2019	In a cellular model, there was a significant difference in the induction of sphingosine-1-phosphate by vitamin D between a control human bronchial epithelial cell line and a cell line overexpressing ORMDL3 (p=0.002).Results suggest prenatal vitamin D supplementation may reduce the risk of early childhood asthma/wheeze via alterations of sphingolipid metabolism dependent on the 17q21 genotype.	Vitamin D	241-250	ORMDL sphingolipid biosynthesis regulator 3	Homo sapiens	199-205
31998380-0	2019	Vitamin D Inhibition of TRPV5 Expression During Osteoclast Differentiation.	Vitamin D	0-9	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	24-29
31998380-3	2019	However, the impact of vitamin D on TRPV5 expression during OC differentiation is not clear.	Vitamin D	23-32	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	36-41
31687010-11	2019	Most vitiligo cases and controls were found to have low levels of vitamin D (either insufficient 20-30 ng/mL or low &lt;20 ng/mL).	Vitamin D	66-75	VAMAS6	Homo sapiens	5-13
31582399-0	2019	Vitamin D enhances responses to interferon-beta in MS.	Vitamin D	0-9	interferon beta 1	Homo sapiens	32-47
31582399-4	2019	RESULTS: Vitamin D enhanced in vitro IFN responses, as measured by induction of p-Y-STAT1 and MxA in MNCs, T cells, and monocytes.	Vitamin D	9-18	MX dynamin like GTPase 1	Homo sapiens	94-97
31582399-6	2019	The combination of vitamin D plus IFN-beta reduced Th1 and Th17 cytokines, and increased Th2 responses, reversing the effect of IFN-beta alone.	Vitamin D	19-28	interferon beta 1	Homo sapiens	128-136
31582399-9	2019	CONCLUSION: Vitamin D enhances IFN-beta induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-beta alone.	Vitamin D	12-21	interferon beta 1	Homo sapiens	31-39
31509973-8	2019	Vitamin D deficiency itself also led to decreased LC3 II levels in the liver and decreased insulin receptor staining in the ovaries.	Vitamin D	0-9	insulin receptor	Rattus norvegicus	91-107
31030237-0	2019	Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.	Vitamin D	0-9	CREB regulated transcription coactivator 1	Mus musculus	62-68
31289106-5	2019	Here we used nuclear magnetic resonance (NMR) spectroscopy to monitor the structure of 15N-labeled full-length Adx from rat while forming the complex with rat CYP24A1 in the ligand-free state or bound to either 1,25(OH)2D3 or the vitamin-D supplement 1alpha(OH)D3.	Vitamin D	230-239	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	159-166
31289106-8	2019	These findings provide a structural basis for the poor substrate turnover of side-chain-modified vitamin-D analogs, while also confirming that specificity of the CYP24A1-ligand interaction influences specificity of CYP24A1-Adx recognition.	Vitamin D	97-106	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	162-169
31289106-8	2019	These findings provide a structural basis for the poor substrate turnover of side-chain-modified vitamin-D analogs, while also confirming that specificity of the CYP24A1-ligand interaction influences specificity of CYP24A1-Adx recognition.	Vitamin D	97-106	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	215-222
31289106-9	2019	SIGNIFICANCE STATEMENT: Mitochondrial cytochrome P450 enzymes, such as CYP24A1 responsible for catabolizing vitamin-D and its analogs, rely on a protein-protein interaction with a ferredoxin in order to receive delivery of the electrons required for catalysis.	Vitamin D	108-117	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	71-78
31455010-0	2019	Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D.	Vitamin D	103-112	LDL receptor related protein 2	Homo sapiens	34-41
31455010-10	2019	Our results indicate that megalin has a minor effect on semi-selective activities of vitamin D analogs.	Vitamin D	85-94	LDL receptor related protein 2	Homo sapiens	26-33
31089808-13	2019	CONCLUSIONS: This study suggests that patients with lateral canal BPPV have increased patient-perceived disability, lower vitamin D-levels and longer duration of symptoms.	Vitamin D	122-131	benign paroxysmal positional vertigo	Homo sapiens	66-70
31252278-7	2019	However, after vitamin D intake, a positive correlation was seen between 25OHD and OPG but not before.	Vitamin D	15-24	TNF receptor superfamily member 11b	Homo sapiens	83-86
31084577-5	2019	In addition, immunocytochemistry, quantitative real-time PCR, and immunoblotting analysis showed that vitamin D increased endothelial interconnections through vascular endothelial cadherin (VE-cadherin) junctions and by impacting cell dynamics through cofilin and VE-cadherin phosphorylation.	Vitamin D	102-111	cofilin 1	Homo sapiens	252-259
30802957-10	2019	Cultured GEC expressed two 25-hydroxylases (CYP27A1 and CYP2R1), as well as 1-alpha hydroxylase, enabling conversion of vitamin D to both 25(OH)D3 and 1,25(OH)2 D3 .	Vitamin D	120-129	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	56-62
31456837-2	2019	Vitamin D has the potential to modulate the inflammatory response to harmful particles in patients with Chronic Obstructive Pulmonary Disease (COPD).	Vitamin D	0-9	COPD	Homo sapiens	143-147
31456837-3	2019	AIM: This study aimed to determine the levels of vitamin D, MMP-9, and TIMP-1 in COPD subjects, healthy smokers and nonsmokers of Indonesian citizens.	Vitamin D	49-58	COPD	Homo sapiens	81-85
31456837-7	2019	RESULTS: The levels of vitamin D in COPD (21.96 +- 6.62ng/mL) and healthy smokers (27.87 +- 7.08 ng/mL) were significantly (p &lt; 0.001) lower compared to that in healthy non-smokers (31.71 +- 9.24 ng/mL).	Vitamin D	23-32	COPD	Homo sapiens	36-40
31456837-10	2019	CONCLUSION: The present study showed the lowest level of vitamin D, the highest level of MMP-9 and TIMP-1 in the COPD subjects.	Vitamin D	57-66	COPD	Homo sapiens	113-117
31231498-11	2019	Conclusion: Vitamin D might contribute in ameliorating diabetes complications not only by improving blood glucose and insulin levels, but also by suppressing AGER and OGT gene expression in the liver.	Vitamin D	12-21	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	167-170
31147591-2	2019	Several studies indicate that the bioactive vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits proliferation and promotes epithelial differentiation of colon carcinoma cells in part through antagonism of the Wnt/beta-catenin pathway.	Vitamin D	44-53	Wnt family member 3A	Homo sapiens	231-234
30962270-9	2019	The regression analyses demonstrated that vitamin D deficiency was associated with BPPV and recurrent BPPV with an odds ratio of 2.15 (95% confidence interval [CI], 1.30-4.32; P=0.006) and 5.16 (95% CI, 1.00-34.12; P=0.05).	Vitamin D	42-51	benign paroxysmal positional vertigo	Homo sapiens	83-87
30962270-9	2019	The regression analyses demonstrated that vitamin D deficiency was associated with BPPV and recurrent BPPV with an odds ratio of 2.15 (95% confidence interval [CI], 1.30-4.32; P=0.006) and 5.16 (95% CI, 1.00-34.12; P=0.05).	Vitamin D	42-51	benign paroxysmal positional vertigo	Homo sapiens	102-106
30995823-6	2019	In their report on the roles of vitamin D status during early life development in Australia, Di Marco et al [...].	Vitamin D	32-41	macrophage receptor with collagenous structure	Homo sapiens	96-101
29799022-0	2019	Lactase persistence may explain the paradoxical findings of high vitamin D concentrations in Europeans living in areas of low UV-B irradiation.	Vitamin D	65-74	lactase	Homo sapiens	0-7
30883492-3	2019	We also describe the development of therapeutic options to prevent recurrences of BPPV and introduce results from a recent randomized controlled trial on the effect of vitamin D and calcium supplementation in preventing BPPV recurrences.	Vitamin D	168-177	benign paroxysmal positional vertigo	Homo sapiens	220-224
30883492-5	2019	RECOMMENDATIONS FOR CLINICAL PRACTICE: Restoration of impaired calcium metabolism with supplementation of vitamin D or estrogen should be considered in the treatment of individuals with frequent recurrences of BPPV.	Vitamin D	106-115	benign paroxysmal positional vertigo	Homo sapiens	210-214
30499618-0	2019	Effects of vitamin D and calcium on expression of MSH2 and transforming growth factors in normal-appearing colorectal mucosa of sporadic colorectal adenoma patients: A randomized clinical trial.	Vitamin D	11-20	mutS homolog 2	Homo sapiens	50-54
30921339-3	2019	Osteoblasts/osteocytes produce fibroblast growth factor 23 (FGF23), a hormone regulating renal phosphate and vitamin D handling.	Vitamin D	109-118	fibroblast growth factor 23	Rattus norvegicus	31-58
30921339-3	2019	Osteoblasts/osteocytes produce fibroblast growth factor 23 (FGF23), a hormone regulating renal phosphate and vitamin D handling.	Vitamin D	109-118	fibroblast growth factor 23	Rattus norvegicus	60-65
30726465-10	2019	CONCLUSIONS: Suberythemal sun exposure with sunscreen (SPF 30) provides similar vitamin D serum variation than without photoprotection in healthy adults.	Vitamin D	80-89	survival motor neuron domain containing 1	Homo sapiens	55-61
31425941-3	2019	Since prediabetic obese populations have the greatest risk to develop to T2D, it was important in our study to examine serum 25(OH) D3 concentration among prediabetic obese patients and to evaluate the correlation between serum level of vitamin D and BMI, FBS, HOMA IR and HbA1c among prediabetes patients.	Vitamin D	237-246	hemoglobin subunit alpha 1	Homo sapiens	273-277
31425951-0	2019	Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: A randomized, placebo-controlled, double-blind clinical trial.	Vitamin D	11-20	chitinase 3 like 1	Homo sapiens	52-58
31425951-5	2019	Therefore, this study was designed to investigate effects of vitamin D supplementation on serum levels of YKL-40 and MCP-1 involved in the development of diabetic complications.	Vitamin D	61-70	chitinase 3 like 1	Homo sapiens	106-112
31425951-9	2019	Vitamin D supplementation also significantly reduced serum YKL-40 levels (-22.7 vs. -2.4 ng/ml; (p-value = 0.003)).	Vitamin D	0-9	chitinase 3 like 1	Homo sapiens	59-65
31425951-12	2019	CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency.	Vitamin D	19-28	chitinase 3 like 1	Homo sapiens	77-83
31425951-13	2019	Vitamin D might contribute in reducing diabetic complications via modulating YKL-40 and MCP-1 signaling pathways.	Vitamin D	0-9	chitinase 3 like 1	Homo sapiens	77-83
30805403-9	2019	In addition, expression of GFAT, a key regulatory enzyme in the hexosamine pathway, was significantly reduced following vitamin D administration.	Vitamin D	120-129	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	27-31
29784241-1	2018	OBJECTIVE: Patients with benign paroxysmal positional vertigo (BPPV) can have vitamin D deficiency, which is a cause of abnormal bone turnover.	Vitamin D	78-87	benign paroxysmal positional vertigo	Homo sapiens	63-67
30205014-0	2018	Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-beta1 expression in hepatocellular carcinoma-induced in rats.	Vitamin D	0-9	caspase 3	Rattus norvegicus	75-84
30205014-6	2018	Treatment with 5-FU + Vit D significantly decreased gene expression of nuclear factor erythroid 2-related factor 2 (NrF2) and transforming growth factor beta1 (TGF-beta1) at both the gene and protein level and serum AFP concentrations in comparison with their corresponding monotherapy.	Vitamin D	22-27	alpha-fetoprotein	Rattus norvegicus	216-219
30205014-7	2018	Moreover, 5-FU + Vit D treatment enhanced apoptosis by increasing caspase-3 gene and protein expression.	Vitamin D	17-22	caspase 3	Rattus norvegicus	66-75
30205014-9	2018	Combination therapy in a TAA-induced HCC rat model was more effective than 5-FU or Vit D through the modulation of TGF-beta1, caspase-3, and NrF2 expressions.	Vitamin D	83-88	caspase 3	Rattus norvegicus	126-135
30515164-4	2018	Galacto-oligosacharides (GOS) and vitamin D are associated with reduced pro-inflammatory cytokine levels in serum, and increased TLR7/8 responses, respectively.	Vitamin D	34-43	toll like receptor 7	Bos taurus	129-135
30267995-7	2018	Conserved vitamin D-responsive element (VDRE)-type sequences in the Bhmt1 and Ikzf2 promoters, the universal need for methionine in epigenetic regulation, and betaine"s protective effects in MTHFR-deficiency suggest similar regulatory mechanisms exist in humans.	Vitamin D	10-19	betaine--homocysteine S-methyltransferase	Homo sapiens	68-73
30267995-7	2018	Conserved vitamin D-responsive element (VDRE)-type sequences in the Bhmt1 and Ikzf2 promoters, the universal need for methionine in epigenetic regulation, and betaine"s protective effects in MTHFR-deficiency suggest similar regulatory mechanisms exist in humans.	Vitamin D	10-19	IKAROS family zinc finger 2	Homo sapiens	78-83
30408071-9	2018	Finally, there was a strong and significant negative correlation between the survival capacity (MAP1LC3B/BECN1) and both maternal vitamin D and placental VDR in the preeclampsia groups.	Vitamin D	130-139	microtubule associated protein 1 light chain 3 beta	Homo sapiens	96-104
30284387-5	2018	Our aim was to explore whether NOD2 gene mutations have an effect on the disease phenotype, vitamin D levels, and on TDM in CD patients.	Vitamin D	92-101	nucleotide binding oligomerization domain containing 2	Homo sapiens	31-35
30008960-0	2018	Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines.	Vitamin D	8-17	monoamine oxidase A	Rattus norvegicus	122-127
30038585-0	2018	Renal Memo1 Differentially Regulates the Expression of Vitamin D-Dependent Distal Renal Tubular Calcium Transporters.	Vitamin D	55-64	mediator of cell motility 1	Mus musculus	6-11
30038585-7	2018	When the mice were challenged by a vitamin D deficient diet, serum FGF23 concentration and TRPV5 membrane abundance were decreased, but NCX1 abundance remained increased.	Vitamin D	35-44	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	91-96
30038585-8	2018	Collectively, renal distal calcium transport proteins (TRPV5 and Calbindin-D28k) in this model were altered by Memo- and vitamin-D dependent mechanisms, except for NCX1 which was vitamin D-independent.	Vitamin D	121-130	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	55-60
30283909-2	2018	Activation of vitamin D by renal 1alpha-hydroxylation is dependent on protein binding because 1,25-dihydroxyvitamin D (1,25(OH)2D3) is formed after megalin-mediated reabsorption of 25-hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP).	Vitamin D	14-23	LDL receptor related protein 2	Homo sapiens	148-155
29771914-2	2018	Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation.	Vitamin D	0-9	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	64-70
29272984-1	2018	OBJECTIVE: Several studies have reported the association of benign paroxysmal positional vertigo (BPPV) with vitamin D deficiency.	Vitamin D	109-118	benign paroxysmal positional vertigo	Homo sapiens	98-102
29272984-7	2018	The regression analyses demonstrated that vitamin D deficiency was associated with BPPV with an odds ratio of 2.1 (95% confidence interval = 1.1-3.1, p = .031).	Vitamin D	42-51	benign paroxysmal positional vertigo	Homo sapiens	83-87
29731626-1	2018	Background: The prevalence of individuals deficient in vitamin D (defined as a serum level of the stable metabolite 25(OH)D &lt;50 nmol/L) is increasing in countries with low annual ultraviolet (UV) radiation and among individuals unable to perform outdoor activities, for example, COPD patients.	Vitamin D	55-64	COPD	Homo sapiens	282-286
29731626-9	2018	Among vitamin D-deficient COPD subjects, 25(OH) D correlated positively with forced expiratory volume in 1 second as % predicted, Modified British Medical Research Council score, blood oxygenation, food portion size, Mediterranean Diet Score and Ultraviolet Score.	Vitamin D	6-15	COPD	Homo sapiens	26-30
29731626-10	2018	Conclusion: Vitamin D deficiency was common among healthy individuals and COPD subjects.	Vitamin D	12-21	COPD	Homo sapiens	74-78
29731626-12	2018	The present study emphasizes the need to routinely monitor vitamin D status among patients with advanced COPD and to consider to medicate those with vitamin D deficiency with vitamin D supplementation.	Vitamin D	59-68	COPD	Homo sapiens	105-109
29628342-0	2018	MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin.	Vitamin D	18-27	clusterin	Homo sapiens	104-113
28765037-0	2018	Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility.	Vitamin D	0-9	CD14 molecule	Homo sapiens	47-51
28765037-9	2018	CD14 expression however, was upregulated in both HC and AD patients after vitamin D treatment (p&lt;0.001, respectively).	Vitamin D	74-83	CD14 molecule	Homo sapiens	0-4
28765037-10	2018	HC showed higher CD14 transcription level than AD patients after vitamin D treatment (p=0.04).	Vitamin D	65-74	CD14 molecule	Homo sapiens	17-21
28765037-13	2018	Also HC monocytes" CD14 transcription after IL1beta and vitamin D co-stimulation differed according to HLA risk profile.	Vitamin D	56-65	CD14 molecule	Homo sapiens	19-23
28926322-0	2018	Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever.	Vitamin D	0-9	MEFV innate immuity regulator, pyrin	Homo sapiens	97-125
29243851-1	2018	The vitamin D-deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D-deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and liver cholesterol, and a reduction in cholesterol 7alpha-hydroxylase (Cyp7a1, rate-limiting enzyme for cholesterol metabolism) and renal Oat3 mRNA/protein expression levels.	Vitamin D	4-13	parathyroid hormone	Mus musculus	212-231
29172936-1	2018	Objectives The aim of this report is to describe the identification of a novel vitamin D metabolite, a C-3, alpha-epimer of 25-hydroxycholecalciferol (3-epi-25(OH)D3), in serum and plasma extracts of cat blood and compare its abundance in cat, dog and rat serum to 25-hydroxycholecalciferol (25(OH)D3), a conventional marker of vitamin D status.	Vitamin D	79-88	complement C3	Canis lupus familiaris	103-106
29172936-1	2018	Objectives The aim of this report is to describe the identification of a novel vitamin D metabolite, a C-3, alpha-epimer of 25-hydroxycholecalciferol (3-epi-25(OH)D3), in serum and plasma extracts of cat blood and compare its abundance in cat, dog and rat serum to 25-hydroxycholecalciferol (25(OH)D3), a conventional marker of vitamin D status.	Vitamin D	328-337	complement C3	Canis lupus familiaris	103-106
29172936-12	2018	Importantly, this finding indicates a C-3 epimerization pathway is quantitatively significant for vitamin D metabolism in domestic cats, making 3-epi-25(OH)D3 assays essential for the evaluation of vitamin D status in cats and positioning the cat as a novel model for study of this pathway.	Vitamin D	98-107	complement C3	Canis lupus familiaris	38-41
29172936-12	2018	Importantly, this finding indicates a C-3 epimerization pathway is quantitatively significant for vitamin D metabolism in domestic cats, making 3-epi-25(OH)D3 assays essential for the evaluation of vitamin D status in cats and positioning the cat as a novel model for study of this pathway.	Vitamin D	198-207	complement C3	Canis lupus familiaris	38-41
29162485-0	2018	Expression and regulation of CYP17A1 and 3beta-hydroxysteroid dehydrogenase in cells of the nervous system: Potential effects of vitamin D on brain steroidogenesis.	Vitamin D	129-138	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	29-36
29162485-7	2018	As part of this study we also examined potential effects on CYP17A1 and 3beta-HSD by vitamin D, a compound previously shown to have regulatory effects in steroid hormone-producing cells outside the brain.	Vitamin D	85-94	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	60-81
29162485-11	2018	We found that vitamin D suppressed CYP17A1-mediated activity by 20% in SH-SY5Ycells and astrocytes.	Vitamin D	14-23	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	35-42
29162485-14	2018	These data suggest that vitamin D-mediated regulation of CYP17A1 and 3beta-HSD, particularly on the transcriptional level, may play a role in the nervous system.	Vitamin D	24-33	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	57-78
29731791-0	2018	The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-beta in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis.	Vitamin D	26-35	transforming growth factor, beta 1	Mus musculus	67-75
29710028-4	2018	The protein expressions of markers linked with the vitamin D action were altered by VDD (vitamin D receptor VDR, 25-hydroxyvitamin D-24-hydroxylase CYP24A1, CYP27B1, and CYP2R1).	Vitamin D	51-60	cytochrome P450, family 2, subfamily r, polypeptide 1	Mus musculus	170-176
29299028-9	2017	Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant.	Vitamin D	68-77	forkhead box P3	Homo sapiens	87-92
29299028-9	2017	Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant.	Vitamin D	68-77	forkhead box P3	Homo sapiens	149-154
27923276-6	2017	Maternal serum PAPP-A (MoM) and f-beta Hcg (MoM) were significantly lower in the vitamin D deficiency group (p= 0.008, p = 0.003, respectively).	Vitamin D	81-90	pappalysin 1	Homo sapiens	15-21
28703134-1	2017	Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor.	Vitamin D	0-9	SMAD family member 3	Homo sapiens	135-140
28728941-3	2017	We hypothesized that mineral homeostasis is differentially affected by R568 and 1,25D with respect to the PTH-vitamin D-FGF23-Klotho axis and bone health.	Vitamin D	110-119	parathyroid hormone	Mus musculus	106-109
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	jagged canonical Notch ligand 2	Homo sapiens	105-109
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	hes family bHLH transcription factor 1	Homo sapiens	111-115
27631120-9	2017	Depressive symptoms (hazard ratio [HR], 1.93; P = .031) and vitamin D deficiency (HR, 1.84, P = .036) predicted shorter cardiac event-free survival in Cox regression.	Vitamin D	60-69	cytochrome c oxidase subunit 8A	Homo sapiens	151-154
28578001-9	2017	These findings indicate that p38alpha and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 expression.	Vitamin D	82-91	growth arrest and DNA damage inducible alpha	Homo sapiens	42-53
28794437-2	2017	Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could maintain CD28 expression.	Vitamin D	79-88	CD28 molecule	Homo sapiens	26-30
28794437-2	2017	Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could maintain CD28 expression.	Vitamin D	79-88	CD28 molecule	Homo sapiens	104-108
28779150-0	2017	Vitamin D attenuates myofibroblast differentiation and extracellular matrix accumulation in nasal polyp-derived fibroblasts through smad2/3 signaling pathway.	Vitamin D	0-9	SMAD family member 2	Homo sapiens	132-137
28274898-12	2017	Unlike the general tendencies in the literature, our study suggests that osteoporosis and vitamin D deficiency are not risk factors for BPPV; we conclude that the coexistence of BPPV with osteoporosis and vitamin D deficiency is coincidental.	Vitamin D	205-214	benign paroxysmal positional vertigo	Homo sapiens	178-182
28130827-1	2017	SCOPE: Osteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol.	Vitamin D	155-164	fibroblast growth factor 23	Rattus norvegicus	27-54
28130827-1	2017	SCOPE: Osteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol.	Vitamin D	155-164	fibroblast growth factor 23	Rattus norvegicus	56-61
28304097-5	2017	We employed an extended 20-min run time on LC-MS/MS to study serum vitamin D metabolites in patients with IIH due to mutations of CYP24A1 or SLC34A1; in unaffected heterozygotes and dialysis patients; in patients with vitamin D deficiency; as well as in normal subjects exhibiting a broad range of 25-OH-D levels.	Vitamin D	67-76	solute carrier family 34 member 1	Homo sapiens	141-148
28843242-13	2017	Among metabolic syndrome indicators, there was a significant direct relationship between vitamin D level with FBS (P=0.013) and SBP (P=0.023).	Vitamin D	89-98	selenium binding protein 1	Homo sapiens	128-131
28391237-7	2017	Secondarily, Cox regression models, based on survival analysis, will determine the extent to which independent variables (including different levels of vitamin D at baseline) predict whether a cardiovascular event will occur, and also when this will be.	Vitamin D	152-161	cytochrome c oxidase subunit 8A	Homo sapiens	13-16
27930980-9	2017	Vitamin D alleviated also insulin resistance, where both IDE, glucagon levels showed significant decrease along with activation of insulin receptor phosphorylation.	Vitamin D	0-9	insulin degrading enzyme	Rattus norvegicus	57-60
27930980-9	2017	Vitamin D alleviated also insulin resistance, where both IDE, glucagon levels showed significant decrease along with activation of insulin receptor phosphorylation.	Vitamin D	0-9	insulin receptor	Rattus norvegicus	131-147
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	autophagy related 16 like 1	Homo sapiens	76-83
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	autophagy related 16 like 1	Homo sapiens	112-119
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	autophagy related 16 like 1	Homo sapiens	112-119
27696575-3	2016	RESULTS: The percentage of CD19+ B cells and NK cytotoxicity at an effector-to-target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group (VDI) than in the vitamin D normal group (VDN) (P&lt;.05 each).	Vitamin D	162-171	CD19 molecule	Homo sapiens	27-31
27525708-9	2016	CONCLUSION: A statistically significant association was determined between Vitamin D and calcium metabolism in patients with idiopathic BPPV.	Vitamin D	75-84	benign paroxysmal positional vertigo	Homo sapiens	136-140
27525708-10	2016	It can be considered that Vitamin D deficiency and decreased ionized Ca level may be a risk for BPPV, not only in patients with osteoporosis but also in all patients.	Vitamin D	26-35	benign paroxysmal positional vertigo	Homo sapiens	96-100
27525708-12	2016	The recurrences might possibly be prevented with supplementary Vitamin D especially in those with recurrent idiopathic BPPV but further studies would be necessary to determine this.	Vitamin D	63-72	benign paroxysmal positional vertigo	Homo sapiens	119-123
27086659-8	2016	FOXP3 molecule expression significantly increased in CAT patients having vitamin D deficiency who were given vitamin D replacement.	Vitamin D	73-82	forkhead box P3	Homo sapiens	0-5
27086659-8	2016	FOXP3 molecule expression significantly increased in CAT patients having vitamin D deficiency who were given vitamin D replacement.	Vitamin D	109-118	forkhead box P3	Homo sapiens	0-5
27456065-0	2016	Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-beta/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation.	Vitamin D	0-9	SMAD family member 3	Mus musculus	84-89
27456065-1	2016	Disruption of the TGF-beta pathway is associated with liver fibrosis and suppression of liver tumorigenesis, conditions associated with low Vitamin D (VD) levels.	Vitamin D	140-149	transforming growth factor, beta 1	Mus musculus	18-26
27271180-12	2016	Vitamin D supplementation significantly decreased serum levels of TNF-alpha and IFN-gamma, upregulated serum levels of IL-10, and had no effect on serum IL-6 levels.	Vitamin D	0-9	tumor necrosis factor	Sus scrofa	66-75
27271180-12	2016	Vitamin D supplementation significantly decreased serum levels of TNF-alpha and IFN-gamma, upregulated serum levels of IL-10, and had no effect on serum IL-6 levels.	Vitamin D	0-9	interferon gamma	Sus scrofa	80-89
26386496-2	2016	This study aims to detect the effect of treatment of severe vitamin D deficiency on the recurrence rate of BPPV.	Vitamin D	60-69	benign paroxysmal positional vertigo	Homo sapiens	107-111
26386496-13	2016	The Odds Ratio for development of recurrence of BPPV in subjects with severe vitamin D deficiency was 4.54 (95% CI: 1.41-14.58, p&lt;0.01).	Vitamin D	77-86	benign paroxysmal positional vertigo	Homo sapiens	48-52
27075619-11	2016	Because MYPT1 serine phosphorylation could activate myosin light chain phosphatase (MLCP), and MLCP activation is an important regulatory machinery of smooth muscle cell relaxation, up-regulation of MYPT1(Ser507) phosphorylation could be a mechanism of vitamin D and/or losartan mediated placental VSMC relaxation.	Vitamin D	253-262	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	8-13
27075619-11	2016	Because MYPT1 serine phosphorylation could activate myosin light chain phosphatase (MLCP), and MLCP activation is an important regulatory machinery of smooth muscle cell relaxation, up-regulation of MYPT1(Ser507) phosphorylation could be a mechanism of vitamin D and/or losartan mediated placental VSMC relaxation.	Vitamin D	253-262	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	199-204
26037530-0	2016	WT1 and interferon-beta-vitamin D association in MS: a longitudinal study.	Vitamin D	24-33	interferon beta 1	Homo sapiens	8-23
26037530-1	2016	BACKGROUND: It has been suggested that polymorphisms in the WT1 gene modulate the effect of IFN-beta treatment in multiple sclerosis (MS) through regulation of the relationship between IFN-beta and vitamin D.	Vitamin D	198-207	interferon beta 1	Homo sapiens	92-100
26037530-1	2016	BACKGROUND: It has been suggested that polymorphisms in the WT1 gene modulate the effect of IFN-beta treatment in multiple sclerosis (MS) through regulation of the relationship between IFN-beta and vitamin D.	Vitamin D	198-207	interferon beta 1	Homo sapiens	185-193
27386060-1	2016	BACKGROUND: Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency.	Vitamin D	69-78	benign paroxysmal positional vertigo	Homo sapiens	50-54
27386060-2	2016	This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV.	Vitamin D	56-65	benign paroxysmal positional vertigo	Homo sapiens	98-102
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	48-57	benign paroxysmal positional vertigo	Homo sapiens	106-110
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	48-57	benign paroxysmal positional vertigo	Homo sapiens	220-224
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	48-57	benign paroxysmal positional vertigo	Homo sapiens	220-224
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	275-284	benign paroxysmal positional vertigo	Homo sapiens	220-224
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	275-284	benign paroxysmal positional vertigo	Homo sapiens	220-224
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	275-284	benign paroxysmal positional vertigo	Homo sapiens	220-224
27386060-9	2016	RESULTS: After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.	Vitamin D	275-284	benign paroxysmal positional vertigo	Homo sapiens	220-224
27386060-10	2016	CONCLUSION: This study indicates that correction of vitamin D deficiency in BPPV provides additional benefit to rehabilitation therapy (Epley maneuver) regarding duration of improvement.	Vitamin D	52-61	benign paroxysmal positional vertigo	Homo sapiens	76-80
26817629-7	2016	Beneficial actions of treatments with vitamin D or calcitriol on BCa and surrounding adipose tissue included repressed Esr1, aromatase, and Cox2 expression; decreased tumor-derived estrogen and PGE2; reduced expression of leptin receptors; and increased adiponectin receptors.	Vitamin D	38-47	cytochrome c oxidase II, mitochondrial	Mus musculus	140-144
26462119-1	2016	Prospective epidemiological studies have consistently shown a relationship between vitamin D deficiency, insulin resistance, and type 2 diabetes mellitus (DM2).	Vitamin D	83-92	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	155-158
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	aldo-keto reductase family 1 member B10	Homo sapiens	90-97
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	aldo-keto reductase family 1 member C3	Homo sapiens	241-247
26804483-10	2016	Observations suggesting an association between idiopathic BPPV and vitamin D deficiency and osteoporosis indicate that BPPV may share risk factors with other common geriatric conditions, which highlights the importance of moving beyond purely otological considerations and addressing the needs of older adults with vertigo through a systems-based multidisciplinary approach.	Vitamin D	67-76	benign paroxysmal positional vertigo	Homo sapiens	58-62
26804483-10	2016	Observations suggesting an association between idiopathic BPPV and vitamin D deficiency and osteoporosis indicate that BPPV may share risk factors with other common geriatric conditions, which highlights the importance of moving beyond purely otological considerations and addressing the needs of older adults with vertigo through a systems-based multidisciplinary approach.	Vitamin D	67-76	benign paroxysmal positional vertigo	Homo sapiens	119-123
25758239-6	2016	We demonstrated that in the healthy colon of mice, high vitamin D diet (2500 IU/kg diet) increased expression of differentiation and apoptosis markers, decreased expression of proliferation markers and significantly upregulated CaSR mRNA expression, compared with low vitamin D diet (100 IU/kg diet).	Vitamin D	56-65	calcium-sensing receptor	Mus musculus	228-232
27298518-7	2016	Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation (p = 0.006).	Vitamin D	9-18	toll like receptor 3	Homo sapiens	73-77
26567701-1	2016	The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting.	Vitamin D	194-203	fibroblast growth factor 19	Homo sapiens	48-53
26885262-6	2015	MEK/ERK and PTEN/PI3K/Akt/mTOR were both found critically involved in vitamin D-induced autophagy.	Vitamin D	70-79	midkine	Mus musculus	0-3
26476188-4	2015	Analysis of 24 vitamin D analogs, bearing similar molecular structures complexed with Vitamin D Receptor enabled the design of new agonists forming all advantageous interaction to the receptor, coded TB1, TB2, TB3 and TB4.	Vitamin D	15-24	receptor accessory protein 5	Homo sapiens	205-208
26276370-0	2015	PTH and Vitamin D Repress DMP1 in Cementoblasts.	Vitamin D	8-17	dentin matrix protein 1	Mus musculus	26-30
26327926-8	2015	We also demonstrate that AIrA is genetically determined: single nucleotide polymorphisms located in genes encoding key factors for the metabolism of estrogens and vitamin D (CYP17A1, VDR, and CYP27B1) are associated with self-reported arthralgia during AI therapy.	Vitamin D	163-172	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	174-181
26307011-3	2015	We investigated the role of XLalphas in mediating signaling by parathyroid hormone (PTH), which activates a G protein-coupled receptor (GPCR) that stimulates both Galphas and Galphaq/11 in renal proximal tubules to maintain phosphate and vitamin D homeostasis.	Vitamin D	238-247	parathyroid hormone	Mus musculus	63-82
25618750-5	2015	However, the PEDF level was significantly higher in the vitamin D group (p = 0.013).	Vitamin D	56-65	serpin family F member 1	Rattus norvegicus	13-17
25618750-7	2015	Vitamin D effectively increases PEDF, which has an opposing effect on VEGF, which plays a key role in OHSS.	Vitamin D	0-9	serpin family F member 1	Rattus norvegicus	32-36
25736056-8	2015	Four of these 11 genes (CYP24A1, CLMN, EFTUD1, and SERPINB1) were also identified as 1,25D responsive in human breast tumor explants, suggesting that this gene signature may prove useful as a biomarker of vitamin D exposure in breast tissue.	Vitamin D	205-214	elongation factor like GTPase 1	Homo sapiens	39-45
25736056-8	2015	Four of these 11 genes (CYP24A1, CLMN, EFTUD1, and SERPINB1) were also identified as 1,25D responsive in human breast tumor explants, suggesting that this gene signature may prove useful as a biomarker of vitamin D exposure in breast tissue.	Vitamin D	205-214	serpin family B member 1	Homo sapiens	51-59
26067744-0	2015	Association between colchicine resistance and vitamin D in familial Mediterranean fever.	Vitamin D	46-55	MEFV innate immuity regulator, pyrin	Homo sapiens	59-87
26212084-7	2015	We further identify a functional vitamin D response element (VDRE) 5"-AGATAACAAAGGTCA-3" in the Cdx1 site of the Claudin-2 promoter.	Vitamin D	33-42	caudal type homeobox 1	Mus musculus	96-100
26212084-7	2015	We further identify a functional vitamin D response element (VDRE) 5"-AGATAACAAAGGTCA-3" in the Cdx1 site of the Claudin-2 promoter.	Vitamin D	33-42	claudin 2	Mus musculus	113-122
26212084-8	2015	It is a VDRE required for the regulation of Claudin-2 by vitamin D.	Vitamin D	57-66	claudin 2	Mus musculus	44-53
25753408-7	2015	Expression of neurotrophin genes brain-derived neurotrophic factor (Bdnf) and transforming growth factor-beta1 (Tgf-beta1) was altered, with Bdnf reduced at E14.5 and increased at E17.5 following vitamin D deficiency.	Vitamin D	196-205	transforming growth factor, beta 1	Mus musculus	112-121
25753408-10	2015	At E17.5, brain tyrosine hydroxylase (TH) gene expression was reduced in females, as was TH protein localization (to identify dopamine neurons) in the substantia nigra of vitamin D-deficient female foetuses.	Vitamin D	171-180	tyrosine hydroxylase	Mus musculus	38-40
25774554-10	2015	Moreover, vitamin D deficiency significantly attenuated HFD-induced up-regulation of hepatic peroxisome proliferator-activated receptor gamma, which promoted hepatic lipid uptake and lipid droplet formation, and its target gene cluster of differentiation 36.	Vitamin D	10-19	peroxisome proliferator activated receptor gamma	Mus musculus	93-141
25910558-0	2015	Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis.	Vitamin D	0-9	matrix metallopeptidase 2	Homo sapiens	37-63
25910558-3	2015	The aim of this study was to understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp-derived fibroblasts.	Vitamin D	52-61	matrix metallopeptidase 2	Homo sapiens	163-189
25910558-3	2015	The aim of this study was to understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp-derived fibroblasts.	Vitamin D	52-61	matrix metallopeptidase 2	Homo sapiens	191-196
25910558-10	2015	The inhibitory effect of vitamin D derivatives on MMP-2 and MMP-9 secretion could potentiate their application in pharmacotherapy of Taiwanese CRSwNP patients.	Vitamin D	25-34	matrix metallopeptidase 2	Homo sapiens	50-55
25826541-5	2015	Mice lacking JAK3, a kinase essential for immune homeostasis, displayed mild renal inflammation, elevated renal CYP27B1 expression, and altered phosphate metabolism, linking immune signaling to vitamin D metabolism in the kidney.	Vitamin D	194-203	Janus kinase 3	Mus musculus	13-17
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	forkhead box P3	Homo sapiens	227-232
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	taste 1 receptor member 1	Homo sapiens	297-300
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	taste 1 receptor member 1	Homo sapiens	328-331
25750305-7	2015	Patients with positive nuclear PAK1 also had low vitamin D levels in their blood (4.51 ng/ml).	Vitamin D	49-58	p21 (RAC1) activated kinase 1	Homo sapiens	31-35
25530010-5	2015	We hypothesized that DIO in growing mice affects bone mineral status and that high vitamin D and calcium intakes will promote mineralization of the growing bone in obesity via Ca(2+) regulatory hormones, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and parathyroid hormone (PTH).	Vitamin D	83-92	parathyroid hormone	Mus musculus	247-266
25530010-5	2015	We hypothesized that DIO in growing mice affects bone mineral status and that high vitamin D and calcium intakes will promote mineralization of the growing bone in obesity via Ca(2+) regulatory hormones, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and parathyroid hormone (PTH).	Vitamin D	83-92	parathyroid hormone	Mus musculus	268-271
25270396-2	2015	Elevated fibroblast growth factor (FGF)-23 in cyclosporine A (CsA) users with SLE are associated with decreased active vitamin D and osteocalcin.	Vitamin D	119-128	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	62-65
25785055-3	2015	In this study, we measured salivary superoxide dismutase (SOD) and metalloproteinsases (MMP) levels in the patients with vitamin B12 and vitamin D treatment.	Vitamin D	137-146	matrix metallopeptidase 2	Homo sapiens	88-91
25785055-7	2015	The salivary MMP 2, MMP 3, and MMP 9 levels of the patients with vitamin D and vitamin B12 treatment were lower than that in the patients without vitamin D and vitamin B12 treatment.	Vitamin D	65-74	matrix metallopeptidase 2	Homo sapiens	13-18
25654506-9	2015	Vitamin D insufficiency was inversely associated with the MAC-Q score (adjusted beta=-2.84, P=0.03), and positively associated with severe cognitive complaint (adjusted OR=10.07, P=0.03).	Vitamin D	0-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	80-87
25549329-9	2014	Adjustment for PD cell CD14/CD45 expression using a mixed linear statistical model also revealed increased expression of CAMP (mRNA in PD cells and protein in effluent) in vitamin D-supplemented patients.	Vitamin D	172-181	CD14 molecule	Homo sapiens	23-27
24722820-7	2014	Furthermore, 48 and 42 kDa caspase-3 cleavage products of cGSN are detected in EAE spinal cords, suggesting enhanced apoptotic activity, but these cleaved products undergo a similar decrease upon vitamin D treatment.	Vitamin D	196-205	caspase 3	Rattus norvegicus	27-36
24902982-11	2014	However, vitamin D deficient patients (&lt;10 ng ml(-1) ) would need an intensive phase of 100 000 IU per 2 weeks (two times) followed 2 weeks later by a maintenance phase of 100 000 IU per 3 months.	Vitamin D	9-18	interleukin 17F	Homo sapiens	49-55
24692218-1	2014	BACKGROUND: Vitamin D has immunomodulatory properties, such as regulation of FOXP3 expression and regulatory T-cell activity.	Vitamin D	12-21	forkhead box P3	Homo sapiens	77-82
25279717-2	2014	We have demonstrated earlier that in vitro treatment of T cells from healthy individuals with TX527, a low-calcemic analog of bioactive vitamin D, can promote a CD4+ CD25high CD127low regulatory profile and imprint a migratory signature specific for homing to sites of inflammation.	Vitamin D	136-145	interleukin 2 receptor subunit alpha	Homo sapiens	166-170
25279717-3	2014	Towards clinical application of vitamin D-induced Tregs in autologous adoptive immunotherapy for type 1 diabetes, we show here that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and TX527 similarly imprint T cells from type 1 diabetes patients with a CD4+ CD25high CD127low regulatory profile, modulate surface expression of skin- and inflammation-homing receptors, and increase expression of CTLA-4 and OX-40.	Vitamin D	32-41	interleukin 2 receptor subunit alpha	Homo sapiens	249-253
24858524-10	2014	Vitamin D status was insufficient in 11 and deficient in 8 FRDA patients.	Vitamin D	0-9	frataxin	Homo sapiens	59-63
24833277-0	2014	Dietary vitamin D supplementation attenuates immune responses of pigs challenged with rotavirus potentially through the retinoic acid-inducible gene I signalling pathway.	Vitamin D	8-17	DExD/H-box helicase 58	Sus scrofa	120-150
24833277-9	2014	In conclusion, vitamin D supplementation could activate the RIG-I signalling pathway and thus alleviate the negative effects caused by PRV challenge.	Vitamin D	15-24	DExD/H-box helicase 58	Sus scrofa	60-65
24222043-1	2014	Previous hypertension studies have shown that low levels of vitamin D are linked to elevated renin-angiotensin system.	Vitamin D	60-69	renin	Rattus norvegicus	93-98
24418378-10	2014	TG, SBP, and DBP exhibited linear associations with 25(OH)D. CONCLUSIONS: Vitamin D status is related to cardiometabolic indicators in healthy men.	Vitamin D	74-83	selenium binding protein 1	Homo sapiens	4-7
26327834-8	2014	The highest percentage of women represented profile VIII: attitudes towards prevention of osteoporosis, characterized by insufficient exposure to sunlight and a diet deficient in both calcium and vitamin D.	Vitamin D	196-205	cytochrome c oxidase subunit 8A	Homo sapiens	52-56
24378215-9	2014	Moreover, vitamin D deficiency significantly aggravated the decreases in osteocalcin and IGF-1 mRNA by diabetic state.	Vitamin D	10-19	insulin-like growth factor 1	Mus musculus	89-94
24586832-3	2014	We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1.	Vitamin D	264-273	SUMO specific peptidase 2	Homo sapiens	25-30
24586832-5	2014	In support of their function as novel modulators of the vitamin D hormonal pathway we demonstrate that both SENP1 and SENP2 can interact with VDR and reverse its modification with SUMO2.	Vitamin D	56-65	SUMO specific peptidase 2	Homo sapiens	118-123
24239751-0	2014	Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine.	Vitamin D	54-63	CD86 molecule	Sus scrofa	23-27
24239751-5	2014	There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine.	Vitamin D	147-156	CD86 molecule	Sus scrofa	71-75
24397367-0	2014	Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment.	Vitamin D	0-9	microRNA 181c	Homo sapiens	22-30
24397367-0	2014	Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment.	Vitamin D	0-9	microRNA 20b	Homo sapiens	32-39
24397367-0	2014	Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment.	Vitamin D	0-9	microRNA 15a	Homo sapiens	44-51
24287909-2	2013	The expression of CaBP-9k is detected primarily in intestine that is vitamin D target tissue, and accumulates in the enterocytes of the duodenal villi.	Vitamin D	69-78	S100 calcium binding protein G	Mus musculus	18-25
24287909-4	2013	It has been well established that the expression of CaBP-9k is mediated with vitamin D response element on its promoter and it regulates the amount of intracellular calcium in order to prevent cell death from reaching the toxicity of free calcium.	Vitamin D	77-86	S100 calcium binding protein G	Mus musculus	52-59
24264043-5	2013	In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined.	Vitamin D	59-68	claudin 2	Mus musculus	147-156
24264043-5	2013	In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined.	Vitamin D	59-68	S100 calcium binding protein G	Mus musculus	193-201
24264043-7	2013	With a calcium- and vitamin D-deficient diet, tight junction gene expression was significantly decreased in the duodenum of the CaBP-9k KO mice.	Vitamin D	20-29	S100 calcium binding protein G	Mus musculus	128-135
24251203-7	2013	The results indicate a potential antidiabetic function of vitamin D on GLUT1, GLUT4, VDR, and IR by improving receptor gene expression suggesting a role for vitamin D in regulation of expression of the glucose transporters in muscle cells.	Vitamin D	58-67	solute carrier family 2 member 4	Homo sapiens	78-83
24084050-9	2013	Four variants: rs7975232[A] (VDR), rs732594[A] (SCUBE3), and rs2980[T] and rs2981[A] (PHF-11) showed a significant association with serum Vit D levels in the control group.	Vitamin D	138-143	PHD finger protein 11	Homo sapiens	86-92
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	insulin receptor	Mus musculus	78-94
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	insulin receptor	Mus musculus	96-98
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	insulin receptor	Mus musculus	101-117
23142866-5	2013	The regulation of parathyroid hormone (PTH) secretion by CaSR and the subsequent effects of PTH and vitamin D on TRPV5 constitute an increasingly characterized regulatory loop.	Vitamin D	100-109	transient receptor potential cation channel subfamily V member 5	Homo sapiens	113-118
23770363-3	2013	Using a monocyte cell model, this study examined the hypothesis that vitamin D upregulate glutamate cysteine ligase (GCLC) and glutathione reductase (GR), which catalyzes GSH biosynthesis.	Vitamin D	69-78	glutamate-cysteine ligase catalytic subunit	Homo sapiens	117-121
23770363-3	2013	Using a monocyte cell model, this study examined the hypothesis that vitamin D upregulate glutamate cysteine ligase (GCLC) and glutathione reductase (GR), which catalyzes GSH biosynthesis.	Vitamin D	69-78	glutathione-disulfide reductase	Homo sapiens	127-148
23770363-3	2013	Using a monocyte cell model, this study examined the hypothesis that vitamin D upregulate glutamate cysteine ligase (GCLC) and glutathione reductase (GR), which catalyzes GSH biosynthesis.	Vitamin D	69-78	glutathione-disulfide reductase	Homo sapiens	150-152
23677864-2	2013	We previously demonstrated that type 2 diabetic rats exhibit vitamin D deficiency due to aberrant megalin-mediated endocytosis and excessive urinary excretion of 25-hydroxycholecalciferol (25D3) and vitamin D-binding protein (DBP).	Vitamin D	61-70	GC, vitamin D binding protein	Rattus norvegicus	199-224
23781205-11	2013	In summary, vitamin D deficiency, when combined with cigarette smoke exposure, seemed to accelerate the appearance of emphysemas, perhaps by virtue of an increased protease-antiprotease ratio in the combined VDD-CSE animals.	Vitamin D	12-21	cystathionase (cystathionine gamma-lyase)	Mus musculus	212-215
23322328-15	2013	Pamidronate treatment with vitamin D sufficiency can be effective therapy for the skeletal disease caused by the OPG deficiency form of JPD.	Vitamin D	27-36	TNF receptor superfamily member 11b	Homo sapiens	113-116
23569273-4	2013	In this study, we found that active vitamin D reduced the expression of S1PR2, a chemorepulsive receptor for blood S1P, on circulating osteoclast precursor monocytes both in vitro and in vivo.	Vitamin D	36-45	sphingosine-1-phosphate receptor 2	Mus musculus	72-77
23951985-0	2013	Compliance with the HSE policy on vitamin D supplementation for infants.	Vitamin D	34-43	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	20-23
23281695-11	2013	Accordingly, screening for vitamin D deficiency seems of value in vitiligo patients for the possibility of vitamin D supplementation.	Vitamin D	27-36	VAMAS6	Homo sapiens	66-74
23281695-11	2013	Accordingly, screening for vitamin D deficiency seems of value in vitiligo patients for the possibility of vitamin D supplementation.	Vitamin D	107-116	VAMAS6	Homo sapiens	66-74
23188821-0	2013	Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D.	Vitamin D	115-124	microRNA 98	Homo sapiens	18-29
23188821-3	2013	We screened miRNA profiles in response to vitamin D and found that a tumor suppressive miRNA, miR-98, is transcriptionally induced by 1alpha,25-dihydroxyvitamin D(3) (1,25-VD) in LNCaP.	Vitamin D	42-51	microRNA 98	Homo sapiens	94-100
23585405-7	2013	The vitamin D levels were positively correlated to the percentage of migrated Treg toward TARC (p=0.015) and MDC (p=0.000), but there was no difference in Treg CCR4 expression between SLE patients and healthy controls.	Vitamin D	4-13	C-C motif chemokine ligand 17	Homo sapiens	90-94
23585405-7	2013	The vitamin D levels were positively correlated to the percentage of migrated Treg toward TARC (p=0.015) and MDC (p=0.000), but there was no difference in Treg CCR4 expression between SLE patients and healthy controls.	Vitamin D	4-13	C-C motif chemokine ligand 22	Homo sapiens	109-112
24349821-2	2013	Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP).	Vitamin D	53-62	natriuretic peptide B	Homo sapiens	243-268
24349821-2	2013	Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP).	Vitamin D	53-62	natriuretic peptide B	Homo sapiens	270-273
23071135-6	2013	The vitamin D-mediated restored responses were dependent in part on macrophage CD14 expression.	Vitamin D	4-13	CD14 molecule	Homo sapiens	79-83
23843788-4	2013	Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis.	Vitamin D	0-9	renin	Rattus norvegicus	40-45
22960018-9	2013	The interaction between VDR and PTPN2 polymorphisms in the risk of progression to T1D offers insight concerning the role of vitamin D in the etiology of T1D.	Vitamin D	124-133	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	32-37
23194491-9	2012	CONCLUSIONS: Forty-eight weeks of therapy with an active vitamin D analog reduces LAVi and attenuates the rise of BNP.	Vitamin D	57-66	natriuretic peptide B	Homo sapiens	114-117
23062388-0	2012	Correlation of vitamin D with Foxp3 induction and steroid-sparing effect of immunotherapy in asthmatic children.	Vitamin D	15-24	forkhead box P3	Homo sapiens	30-35
22948213-0	2012	The vitamin D analog ED-71 is a potent regulator of intestinal phosphate absorption and NaPi-IIb.	Vitamin D	4-13	solute carrier family 34 member 2	Rattus norvegicus	88-96
22752077-4	2012	We hypothesised that combining a potent vitamin D(3) analogue (TX527), ciclosporin A (CsA) and anti-CD3 would act to lower the dose while maintaining or even boosting therapeutic efficacy to counteract autoimmune destruction of transplanted islets.	Vitamin D	40-49	CD3 antigen, epsilon polypeptide	Mus musculus	100-103
22903229-10	2012	A positive in vivo correlation between vitamin D status and CD4(+) Foxp3(+)  T cells in the airways was observed in a severe pediatric asthma cohort, supporting the in vitro observations.	Vitamin D	39-48	forkhead box P3	Homo sapiens	67-72
22770938-12	2012	Besides, the activity of various glucose metabolic enzymes (hexokinase, FBPase and G6Pase) as shown by our results and the remarkable shortening of DNA tail length in vitamin D supplemented diabetic group as compared to diabetic group without supplementation further support the idea that vitamin D supplementation might be an add-on therapy for patients with T2DM.	Vitamin D	167-176	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	83-89
22537547-14	2012	Vitamin D deficiency causes increase in the expression of TNF-alpha, thereby increasing inflammation and decreases the expression of VDR and prohibitin.	Vitamin D	0-9	prohibitin	Mus musculus	141-151
22537547-15	2012	Supplementation with vitamin D might reduce the levels of TNF-alpha, thereby increasing the expression of VDR and prohibitin that could be responsible for reducing allergic airway inflammation.	Vitamin D	21-30	prohibitin	Mus musculus	114-124
22595957-7	2012	Further adjustment for vitamin D explained 14 and 6% of these SBP and DBP differences, respectively.	Vitamin D	23-32	selenium binding protein 1	Homo sapiens	62-65
22595957-9	2012	Variation in vitamin D explained 7 and 4% of these SBP and DBP differences.	Vitamin D	13-22	selenium binding protein 1	Homo sapiens	51-54
22595957-11	2012	Vitamin D explained 25 and 17% of the variations in SBP and DBP, respectively, resulting in odds ratio of 1.9 (1.3-2.9) and 2.9 (2.0-4.3), respectively.	Vitamin D	0-9	selenium binding protein 1	Homo sapiens	52-55
22700809-0	2012	Vitamin D and disease activity in multiple sclerosis before and during interferon-beta treatment.	Vitamin D	0-9	interferon beta 1	Homo sapiens	71-86
22700816-1	2012	OBJECTIVE: To determine whether interferon-beta (IFN-beta) medication use is associated with vitamin D levels and whether the two interact in exerting effects on relapse risk.	Vitamin D	93-102	interferon beta 1	Homo sapiens	32-47
22700816-1	2012	OBJECTIVE: To determine whether interferon-beta (IFN-beta) medication use is associated with vitamin D levels and whether the two interact in exerting effects on relapse risk.	Vitamin D	93-102	interferon beta 1	Homo sapiens	49-57
22700816-8	2012	CONCLUSION: In this study, we found that IFN-beta therapy is associated with greater production of vitamin D from sun exposure, suggesting part of the therapeutic effects of IFN-beta on relapse in MS may be through modulation of vitamin D metabolism.	Vitamin D	99-108	interferon beta 1	Homo sapiens	41-49
22700816-8	2012	CONCLUSION: In this study, we found that IFN-beta therapy is associated with greater production of vitamin D from sun exposure, suggesting part of the therapeutic effects of IFN-beta on relapse in MS may be through modulation of vitamin D metabolism.	Vitamin D	99-108	interferon beta 1	Homo sapiens	174-182
22700816-8	2012	CONCLUSION: In this study, we found that IFN-beta therapy is associated with greater production of vitamin D from sun exposure, suggesting part of the therapeutic effects of IFN-beta on relapse in MS may be through modulation of vitamin D metabolism.	Vitamin D	229-238	interferon beta 1	Homo sapiens	41-49
22700816-8	2012	CONCLUSION: In this study, we found that IFN-beta therapy is associated with greater production of vitamin D from sun exposure, suggesting part of the therapeutic effects of IFN-beta on relapse in MS may be through modulation of vitamin D metabolism.	Vitamin D	229-238	interferon beta 1	Homo sapiens	174-182
22700816-9	2012	These findings suggest persons being treated with IFN-beta should have vitamin D status monitored and maintained in the sufficiency range.	Vitamin D	71-80	interferon beta 1	Homo sapiens	50-58
22100522-0	2012	25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.	Vitamin D	10-19	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	36-43
22100522-1	2012	CYP24A1 is the cytochrome P450 component of the 25-hydroxyvitamin D(3)-24-hydroxylase enzyme that catalyzes the conversion of 25-hydroxyvitamin D(3) (25-OH-D(3)) and 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) into 24-hydroxylated products, which constitute the degradation of the vitamin D molecule.	Vitamin D	58-67	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	0-7
22107950-7	2012	Several lines of evidence have shown that the active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] is one of the most potent inducers of receptor activator of NF-kappaB ligand (RANKL), a key molecule for osteoclastogenesis, in vitro.	Vitamin D	61-70	TNF superfamily member 11	Rattus norvegicus	168-206
22107950-7	2012	Several lines of evidence have shown that the active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] is one of the most potent inducers of receptor activator of NF-kappaB ligand (RANKL), a key molecule for osteoclastogenesis, in vitro.	Vitamin D	61-70	TNF superfamily member 11	Rattus norvegicus	208-213
22174023-5	2012	In this study, we tested whether vitamin D (1,25-dihydroxyvitamin D3) regulates expression of AMH mRNA in granulosa cells of the hen.	Vitamin D	33-42	anti-Mullerian hormone	Gallus gallus	94-97
22174023-10	2012	There was a significant (P &lt; 0.05) dose-related decrease in the expression of AMH mRNA in granulosa cells of 3- to 5-mm and 6- to 8-mm follicles in response to vitamin D.	Vitamin D	163-172	anti-Mullerian hormone	Gallus gallus	81-84
22174023-16	2012	Overall, these results suggest that vitamin D regulates AMH expression, and thereby may influence follicle selection in the hen.	Vitamin D	36-45	anti-Mullerian hormone	Gallus gallus	56-59
22114947-5	2012	Of the fat-soluble vitamins, vitamin D holds great promise as an agent for primary and secondary prevention of disease.	Vitamin D	29-38	FAT atypical cadherin 1	Homo sapiens	7-10
22213325-11	2012	Furthermore, vitamin D inhibits proliferation of TGCT cell-lines, potentially via an increase in expression of GADD45.	Vitamin D	13-22	growth arrest and DNA damage inducible alpha	Homo sapiens	111-117
22966878-0	2012	Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients.	Vitamin D	0-9	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	95-99
22966878-6	2012	Most significantly, however, dietary vitamin D intake was strongly negatively associated with DKK1 methylation in Newfoundland (P = 0.001) and a similar trend was observed in Ontario.	Vitamin D	37-46	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	94-98
23029160-3	2012	Exogenous vitamin D increased Ca(2+) influx and expressions of ecac and 25-hydroxyvitamin D(3)-24-hydroxylase (cyp24a1), but downregulated 1alpha-OHase (cyp27b1) with no effects on other Ca(2+) transporters.	Vitamin D	10-19	transient receptor potential cation channel, subfamily V, member 6	Danio rerio	63-67
23029160-5	2012	Taken together, vitamin D-VDRa signaling may stimulate Ca(2+) uptake by upregulating ECaC in zebrafish, thereby clarifying the Ca(2+)-handling function of only a VDR in teleosts.	Vitamin D	16-25	transient receptor potential cation channel, subfamily V, member 6	Danio rerio	85-89
22536373-5	2012	Mice treated with the low vitamin D diet had more calcified lesions and a higher expression of Msx2, Bmp2, and Runx2 in aortic roots than mice fed recommended or high amounts of vitamin D (P&lt;0.001).	Vitamin D	26-35	msh homeobox 2	Mus musculus	95-99
21723567-8	2011	Proliferation of both freshly isolated CD4+ T cells and MBP-specific T cells was significantly inhibited by 1,25(OH)(2) Vitamin D.	Vitamin D	118-129	myelin basic protein	Homo sapiens	56-59
22199266-7	2011	CONCLUSION: Vitamin D analogs appear to be involved in the regulation of extracellular MMP activity and membrane adhesion molecule expression.	Vitamin D	12-21	matrix metallopeptidase 2	Homo sapiens	87-90
21753070-6	2011	After additional adjustment for SDS-body mass index, elevated blood pressure (BP) and MetS remained significantly associated with low vitamin D status.	Vitamin D	134-143	ETS variant transcription factor 3	Homo sapiens	86-90
21736847-5	2011	Oesophageal adenocarcinoma risk was significantly greater for individuals with the highest compared with the lowest tertile of vitamin D intake (OR 1 99, 95 % CI 1 03, 3 86; P for trend = 0 02).	Vitamin D	127-136	olfactory receptor family 7 subfamily E member 16 pseudogene	Homo sapiens	145-152
21561999-3	2011	We previously showed that FGFR1 is the predominant receptor for the hypophosphatemic actions of FGF23 by decreasing renal NaPi-2a and 2c expression while the receptors regulating 1,25(OH)(2)Vitamin D(3) levels remained elusive.	Vitamin D	190-199	fibroblast growth factor receptor 1	Mus musculus	26-31
21561999-8	2011	These data indicate that FGFR3 and 4 are the receptors that regulate serum 1,25(OH)(2)Vitamin D(3) levels in response to FGF23.	Vitamin D	86-95	fibroblast growth factor receptor 3	Mus musculus	25-36
21431899-0	2011	A novel compound heterozygous ROMK mutation presenting as late onset Bartter syndrome associated with nephrocalcinosis and elevated 1,25(OH)(2) vitamin D levels.	Vitamin D	144-153	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	30-34
21816995-5	2011	COPD is associated with reduced systemic levels of vitamin D, which has not only calcemic, but also extracalcemic effects that may play a role in the development of COPD and its consequences.	Vitamin D	51-60	COPD	Homo sapiens	0-4
21816995-5	2011	COPD is associated with reduced systemic levels of vitamin D, which has not only calcemic, but also extracalcemic effects that may play a role in the development of COPD and its consequences.	Vitamin D	51-60	COPD	Homo sapiens	165-169
21504790-2	2011	However, research during the past decade provided substantial evidence that a so called "hormone-like" subgroup of FGFs, comprised of FGF19, FGF21 and FGF23, is involved in the regulation of diverse metabolic pathways to control glucose, lipid, bile acid, phosphate and vitamin D metabolism.	Vitamin D	270-279	fibroblast growth factor 19	Homo sapiens	134-139
21420936-1	2011	1alpha,25-dihydroxyvitamin D(3) (calcitriol), the bioactive metabolite of vitamin D, modulates the activation and inhibits IgE production of anti-CD40 and IL-4 stimulated human peripheral B cells.	Vitamin D	19-28	CD40 molecule	Homo sapiens	146-150
21542320-4	2011	It is shown that there is correlation of the vitamin D with total cholesterol, apolipoprotein A, high and low density lipoproteins and vitamin A and E.	Vitamin D	45-54	lipoprotein(a)	Homo sapiens	79-95
22167840-3	2011	Factors that regulate expression and activity of MGP include vitamin D, retinoic acid, extracellular calcium ions, cytokines, and some hormones.	Vitamin D	61-70	matrix Gla protein	Homo sapiens	49-52
21368380-0	2011	MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer"s disease by vitamin D and curcuminoids.	Vitamin D	76-85	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-5
21152098-8	2010	Vitamin D was a potent inhibitor of retinoic acid-induced myogenesis in the presence of TGF-beta1.	Vitamin D	0-9	transforming growth factor, beta 1	Mus musculus	88-97
20844473-0	2010	Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.	Vitamin D	91-100	fibroblast growth factor 23	Rattus norvegicus	40-45
20685875-4	2010	Rickets is also seen in settings of impaired vitamin D action, due to elevated PTH levels that increase renal phosphate excretion.	Vitamin D	45-54	parathyroid hormone	Mus musculus	79-82
20450955-2	2010	Previously we showed that 1,25D-mediated rat CYP24A1 induction via the two critical VDREs is dependent on a short stretch of nucleotides called vitamin D stimulating element (VSE), located approximately 30bp upstream of VDRE-1 in the rat CYP24A1 promoter.	Vitamin D	144-153	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	45-52
20450955-2	2010	Previously we showed that 1,25D-mediated rat CYP24A1 induction via the two critical VDREs is dependent on a short stretch of nucleotides called vitamin D stimulating element (VSE), located approximately 30bp upstream of VDRE-1 in the rat CYP24A1 promoter.	Vitamin D	144-153	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	238-245
20581062-9	2010	These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans, the ASARM peptide may be involved in the mineralization defects and the PHEX-MEPE interaction may be indirect, as ensuring a better phosphate and vitamin D environment to the mineralizing dentin prevents MEPE cleavage.	Vitamin D	246-255	matrix extracellular phosphoglycoprotein	Homo sapiens	36-40
20581062-9	2010	These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans, the ASARM peptide may be involved in the mineralization defects and the PHEX-MEPE interaction may be indirect, as ensuring a better phosphate and vitamin D environment to the mineralizing dentin prevents MEPE cleavage.	Vitamin D	246-255	matrix extracellular phosphoglycoprotein	Homo sapiens	177-181
20581062-9	2010	These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans, the ASARM peptide may be involved in the mineralization defects and the PHEX-MEPE interaction may be indirect, as ensuring a better phosphate and vitamin D environment to the mineralizing dentin prevents MEPE cleavage.	Vitamin D	246-255	matrix extracellular phosphoglycoprotein	Homo sapiens	177-181
20616348-1	2010	Vitamin D inhibits renin expression and blocks the compensatory induction of renin associated with the use of renin-angiotensin system inhibitors.	Vitamin D	0-9	renin	Rattus norvegicus	19-24
20616348-1	2010	Vitamin D inhibits renin expression and blocks the compensatory induction of renin associated with the use of renin-angiotensin system inhibitors.	Vitamin D	0-9	renin	Rattus norvegicus	77-82
20616348-1	2010	Vitamin D inhibits renin expression and blocks the compensatory induction of renin associated with the use of renin-angiotensin system inhibitors.	Vitamin D	0-9	renin	Rattus norvegicus	77-82
20616348-10	2010	These data demonstrate that vitamin D analogs have potent antihypertrophic activity in part via suppression of renin in the kidney and heart, and combination of these analogs with losartan achieves much better therapeutic effects because of the blockade of the compensatory renin increase.	Vitamin D	28-37	renin	Rattus norvegicus	111-116
20616348-10	2010	These data demonstrate that vitamin D analogs have potent antihypertrophic activity in part via suppression of renin in the kidney and heart, and combination of these analogs with losartan achieves much better therapeutic effects because of the blockade of the compensatory renin increase.	Vitamin D	28-37	renin	Rattus norvegicus	274-279
25610130-9	2010	In conclusion, recent literature has drawn attention to the supplemental doses of vitamin D required to achieve a serum 25-hydroxyvitamin D level of at least 20 ng/ml (50 nmol/l), the serum concentration that is needed to optimize absorption of dietary calcium, suppress excess secretion of parathyroid hormone, and reduce fracture risk as well as prevent long-term negative effects.	Vitamin D	82-91	LOW QUALITY PROTEIN: parathyroid hormone	Meleagris gallopavo	291-310
20435648-4	2010	RESULTS: CD14 was up-regulated, whereas TLR2, TLR4 and TLR9 expression was down-regulated by vitamin D(3) exposure in a time-dependent manner.	Vitamin D	93-102	toll like receptor 9	Homo sapiens	55-59
20435648-6	2010	TLR9-induced IL-6 production was impaired in monocytes treated with vitamin D(3) compared with untreated cells.	Vitamin D	68-77	toll like receptor 9	Homo sapiens	0-4
20435648-7	2010	CONCLUSION: The intracellular TLRs are differentially regulated by vitamin D(3), with TLR9 being down-regulated by vitamin D(3) exposure whereas TLR3 was unaffected.	Vitamin D	67-76	toll like receptor 9	Homo sapiens	86-90
20435648-7	2010	CONCLUSION: The intracellular TLRs are differentially regulated by vitamin D(3), with TLR9 being down-regulated by vitamin D(3) exposure whereas TLR3 was unaffected.	Vitamin D	115-124	toll like receptor 9	Homo sapiens	86-90
20399147-2	2010	Our aim was to verify whether the vitamin D analogue ZK 156979 (ZK) down-regulates adhesion molecules, and decreases MMPs production by PBMC of IBD patients.	Vitamin D	34-43	matrix metallopeptidase 2	Homo sapiens	117-121
20354682-0	2010	Autocrine/paracrine action of vitamin D on FGF23 expression in cultured rat osteoblasts.	Vitamin D	30-39	fibroblast growth factor 23	Rattus norvegicus	43-48
19888899-9	2010	Furthermore, modulation of CDP expression levels in osteoblastic SaM-1 cells affected vitamin D-dependent osteoblast differentiation before the maturation (mineralization) stage.	Vitamin D	86-95	cut like homeobox 1	Homo sapiens	27-30
20057335-0	2010	Modulation of Lgl1 by steroid, retinoic acid, and vitamin D models complex transcriptional regulation during alveolarization.	Vitamin D	50-59	cysteine-rich secretory protein LCCL domain containing 2	Rattus norvegicus	14-18
20172224-10	2010	Vitamin D status of cattle might be important for optimal innate immune function because 1,25(OH)(2)D(3) production in activated monocytes and subsequent upregulation of inducible nitric oxide synthase and RANTES expression was dependent on 25(OH)D(3) availability.	Vitamin D	0-9	C-C motif chemokine 5	Bos taurus	206-212
20156263-3	2010	Vitamin D acts through a nuclear receptor (VDR) and increases the expression of receptor activator of nuclear factor-kappaB ligand (rankl) and muscle segment homeobox 2 (msx2) genes.	Vitamin D	0-9	msh homeobox 2	Felis catus	143-168
20156263-3	2010	Vitamin D acts through a nuclear receptor (VDR) and increases the expression of receptor activator of nuclear factor-kappaB ligand (rankl) and muscle segment homeobox 2 (msx2) genes.	Vitamin D	0-9	msh homeobox 2	Felis catus	170-174
19759552-4	2010	The highest-ranked upregulated gene was miR-203, whose expression was significantly upregulated in response to calcium and other inducers of keratinocyte differentiation such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and vitamin D(3).	Vitamin D	225-234	microRNA 203a	Homo sapiens	40-47
19777446-11	2009	The compensatory TRPV6 transcripts in KO mice may be modulated by endogenous vitamin D(3) via other factors of VDR signaling complexes.	Vitamin D	77-86	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	17-22
19631778-11	2009	We conclude that 1,25D and OCT both at a high dose exert significant effects on Ca and skeletal homeostasis with the principal improvement of Ca status in VDR(-/-) mice, and some of these effects may occur through an alternative vitamin D signaling pathway.	Vitamin D	229-238	plexin A2	Mus musculus	27-30
18829283-1	2009	The hormone 1,25 dihydroxyvitamin D (1,25(OH)(2)D) binds to the nuclear vitamin D receptor (nVDR), which heterodimerizes with retinoid X receptor alpha (RXRalpha), and this complex interacts with specific response elements [vitamin D response elements (VDREs)] to regulate gene transcription.	Vitamin D	26-35	retinoid X receptor alpha	Mus musculus	126-151
18829283-1	2009	The hormone 1,25 dihydroxyvitamin D (1,25(OH)(2)D) binds to the nuclear vitamin D receptor (nVDR), which heterodimerizes with retinoid X receptor alpha (RXRalpha), and this complex interacts with specific response elements [vitamin D response elements (VDREs)] to regulate gene transcription.	Vitamin D	26-35	retinoid X receptor alpha	Mus musculus	153-161
19584236-14	2009	Thus, decreasing PTHrP production by treatment with vitamin D analogues may prove therapeutically beneficial for prostate cancer.	Vitamin D	52-61	parathyroid hormone like hormone	Homo sapiens	17-22
19241402-3	2009	This review details the main intracellular pathways through which vitamin D ligands alone or in different combinations may contribute to pigment restoration in vitiligo, outlines the most recent achievements in vitiligo treatment using vitamin D analogs, and compares their efficacy with other treatment regimens in vitiligo.	Vitamin D	66-75	VAMAS6	Homo sapiens	160-168
19241402-3	2009	This review details the main intracellular pathways through which vitamin D ligands alone or in different combinations may contribute to pigment restoration in vitiligo, outlines the most recent achievements in vitiligo treatment using vitamin D analogs, and compares their efficacy with other treatment regimens in vitiligo.	Vitamin D	66-75	VAMAS6	Homo sapiens	211-219
19241402-3	2009	This review details the main intracellular pathways through which vitamin D ligands alone or in different combinations may contribute to pigment restoration in vitiligo, outlines the most recent achievements in vitiligo treatment using vitamin D analogs, and compares their efficacy with other treatment regimens in vitiligo.	Vitamin D	66-75	VAMAS6	Homo sapiens	211-219
19241402-3	2009	This review details the main intracellular pathways through which vitamin D ligands alone or in different combinations may contribute to pigment restoration in vitiligo, outlines the most recent achievements in vitiligo treatment using vitamin D analogs, and compares their efficacy with other treatment regimens in vitiligo.	Vitamin D	236-245	VAMAS6	Homo sapiens	211-219
19241402-3	2009	This review details the main intracellular pathways through which vitamin D ligands alone or in different combinations may contribute to pigment restoration in vitiligo, outlines the most recent achievements in vitiligo treatment using vitamin D analogs, and compares their efficacy with other treatment regimens in vitiligo.	Vitamin D	236-245	VAMAS6	Homo sapiens	211-219
19244278-12	2009	Modulation of vitamin D signaling by AhR may represent a mechanism underlying cigarette smoking-related diseases.	Vitamin D	14-23	aryl hydrocarbon receptor	Homo sapiens	37-40
22276021-6	2009	Vitamin D and melanoma: cutaneous malignant melanoma (CMM) represents a major public health issue: rates in Italy have almost doubled in the last decade and CMM is frequent among young adults.	Vitamin D	0-9	dysplastic nevus syndrome	Homo sapiens	54-57
22276021-6	2009	Vitamin D and melanoma: cutaneous malignant melanoma (CMM) represents a major public health issue: rates in Italy have almost doubled in the last decade and CMM is frequent among young adults.	Vitamin D	0-9	dysplastic nevus syndrome	Homo sapiens	157-160
22276021-12	2009	In an Italian study, we found that 85% of the participants had insufficient levels of 25(OH)D. We have shown through a meta-analysis of randomized trials that vitamin D supplementation is associated with a significant reduction (7%) in total mortality in healthy subjects and an association between VDR and 25(OH)D and CMM progression has also been demonstrated.	Vitamin D	159-168	dysplastic nevus syndrome	Homo sapiens	319-322
22276021-16	2009	Clinical trial and biomarkers studies: in order to assess whether vitamin D supplementation could improve prognosis of CMM, an Italian multi-centre trial in stage II resected melanoma patients was planned to monitor changes in 25(OH)D. The study will address two important questions regarding the relationship between the biology of VDR and (1) vitamin D metabolism, and (2) CMM prognosis.	Vitamin D	66-75	dysplastic nevus syndrome	Homo sapiens	119-122
18727936-10	2008	Parathyroid hormone which is strongly linked with vitamin D status also may play a role in muscle function; however, distinguishing its role from that of vitamin D has yet to be fully clarified.	Vitamin D	50-59	parathyroid hormone	Mus musculus	0-19
19015318-0	2008	RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.	Vitamin D	35-44	ribosomal protein S6 kinase A5	Homo sapiens	22-26
18832725-5	2008	Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors.	Vitamin D	39-48	homeobox A10	Homo sapiens	242-249
18832725-6	2008	Altogether, these data allow one to conclude that the vitamin D(3)/Hox-A10 pathway supports MafB function during the induction of monocyte differentiation.	Vitamin D	54-63	homeobox A10	Homo sapiens	67-74
18810375-5	2008	The ratio of osteoclast stimulating RANKL and its soluble decoy receptor OPG is modulated by sex hormones, vitamin D, parathyroid hormone, local growth factors and mechanical loading.	Vitamin D	107-116	TNF receptor superfamily member 11b	Homo sapiens	73-76
18585377-0	2008	Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: interactions with endothelial function and thioredoxin-interacting protein.	Vitamin D	0-9	thioredoxin-interacting protein	Oryctolagus cuniculus	127-158
18638371-6	2008	Moreover, a computer search in the rat insulin receptor promoter revealed the existence of two candidate vitamin D response element (VDRE) sequences located at -256/-219 bp and -653/-620 bp, the first overlapped by three and the second by four AP-2-like sites.	Vitamin D	105-114	insulin receptor	Rattus norvegicus	39-55
18432454-5	2008	In addition, each was more effective than 1,25-(OH)2D3(EB1089 &gt; CB1093 &gt; MC1288 &gt; 1,25-(OH)2D3) in the activation of a vitamin D response element from the platelet-derived growth factor (PDGF)-A gene, whose expression is essential for normal alveolarization.	Vitamin D	128-137	platelet derived growth factor subunit A	Rattus norvegicus	196-203
18292499-9	2008	We identified a proximal Ets-1 site and an upstream potential vitamin D response element to be critical for the inducible expression of CCR10 by 1,25-(OH)2D3.	Vitamin D	62-71	C-C motif chemokine receptor 10	Homo sapiens	136-141
18348449-1	2008	To get an optimal vitamin D supplement from the sun at a minimal risk of getting cutaneous malignant melanoma (CMM), the best time of sun exposure is noon.	Vitamin D	18-27	dysplastic nevus syndrome	Homo sapiens	111-114
18348449-3	2008	The reasons for this are (1) The action spectrum for CMM is likely to be centered at longer wavelengths (UVA, ultraviolet A, 320-400 nm) than that of vitamin D generation (UVB, ultraviolet B, 280-320 nm).	Vitamin D	150-159	dysplastic nevus syndrome	Homo sapiens	53-56
18348449-9	2008	This would give a maximal yield of vitamin D at a minimal CMM risk.	Vitamin D	35-44	dysplastic nevus syndrome	Homo sapiens	58-61
17850211-6	2008	These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.	Vitamin D	186-195	transient receptor potential cation channel subfamily V member 5	Homo sapiens	42-47
17471513-2	2007	Smad 3, a downstream component of transforming growth factor-beta (TGFbeta) signaling, has been shown to act as a coactivator of VDR and to possibly regulate the vitamin D signaling pathway.	Vitamin D	162-171	SMAD family member 3	Homo sapiens	0-6
17992255-2	2007	FGF23 is a bone-derived phosphaturic hormone that acts on the kidney to increase phosphate excretion and suppress biosynthesis of vitamin D.	Vitamin D	130-139	fibroblast growth factor 23	Rattus norvegicus	0-5
17904173-9	2007	1,25(OH)(2)D(3) regulates PTHrP expression via a negative vitamin D response element (nVDRE) within the noncoding region of the PTHrP gene.	Vitamin D	58-67	parathyroid hormone like hormone	Homo sapiens	26-31
17904173-9	2007	1,25(OH)(2)D(3) regulates PTHrP expression via a negative vitamin D response element (nVDRE) within the noncoding region of the PTHrP gene.	Vitamin D	58-67	parathyroid hormone like hormone	Homo sapiens	128-133
17660624-2	2007	Physiological calcium reabsorption at the distal tubules depends on an ion channel called TRPV5, expression and function of which is regulated by coordinated actions of PTH and active vitamin D.	Vitamin D	184-193	transient receptor potential cation channel subfamily V member 5	Homo sapiens	90-95
17565270-4	2007	A new class of negative vitamin D response elements, which are E-box-type motifs, bind the bHLH-type transcriptional activator (VDIR) together with a histone acetyltransferase coactivator.	Vitamin D	24-33	transcription factor 3	Homo sapiens	128-132
17565270-5	2007	The vitamin D receptor, activated by vitamin D, does not directly bind to the negative vitamin D response elements, but instead associates with VDIR.	Vitamin D	4-13	transcription factor 3	Homo sapiens	144-148
17565270-5	2007	The vitamin D receptor, activated by vitamin D, does not directly bind to the negative vitamin D response elements, but instead associates with VDIR.	Vitamin D	37-46	transcription factor 3	Homo sapiens	144-148
17408240-2	2007	The vitamin D-induced protein-protein interactions between VDR and fluorophore (Cy3 or Cy5)-labeled TIF2 or SRC-1 were successfully detected by using a new HCHO fixing method of the protein complex on microplates.	Vitamin D	4-13	nuclear receptor coactivator 2	Homo sapiens	100-104
17224126-1	2007	The exact role of calbindin D9k in vitamin D-mediated calcium absorption has been debated but remains unsettled.	Vitamin D	35-44	S100 calcium binding protein G	Mus musculus	18-31
17068479-5	2007	The presence of Vit D (10(-10) M for 4 days) led to heightened expression of terminal differentiation markers (stratum corneum, K10, and loricrin).	Vitamin D	16-21	loricrin cornified envelope precursor protein	Rattus norvegicus	137-145
17244528-4	2007	Various Ca(2+) mobilizing agents (vitamin D(3) compounds, ionomycin, ATP, and thapsigargin) inhibit the activity of mammalian target of rapamycin, a negative regulator of macroautophagy, and induce massive accumulation of autophagosomes in a Beclin 1- and Atg7-dependent manner.	Vitamin D	34-43	autophagy related 7	Homo sapiens	256-260
16737686-5	2006	Moreover, while the Gemini Vitamin D(3) analog Ro3582 modulated the expression of several Vitamin D target genes such as the 24-hydroxylase, CD14, osteocalcin, and osteopontin in both cell lines, Ro3582 regulated many genes involved in cell proliferation and apoptosis, cell adhesion, invasion, angiogenesis as well as cell signaling pathways, such as the BMP and TGF-beta systems, differently in the two cell lines.	Vitamin D	27-36	CD14 molecule	Homo sapiens	141-145
16737686-5	2006	Moreover, while the Gemini Vitamin D(3) analog Ro3582 modulated the expression of several Vitamin D target genes such as the 24-hydroxylase, CD14, osteocalcin, and osteopontin in both cell lines, Ro3582 regulated many genes involved in cell proliferation and apoptosis, cell adhesion, invasion, angiogenesis as well as cell signaling pathways, such as the BMP and TGF-beta systems, differently in the two cell lines.	Vitamin D	90-99	CD14 molecule	Homo sapiens	141-145
16849588-9	2006	This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, which is involved in the antiproliferative action of vitamin D without affecting CYP24 transactivation in breast cancer cells.	Vitamin D	70-79	prohibitin 1	Homo sapiens	41-51
16849588-9	2006	This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, which is involved in the antiproliferative action of vitamin D without affecting CYP24 transactivation in breast cancer cells.	Vitamin D	146-155	prohibitin 1	Homo sapiens	41-51
16886681-5	2006	Using PCR and Western blotting, the expression of CLU was also investigated in various vitamin D-responsive (MeWo, SK-MEL-28) and vitamin D-resistant melanoma cell lines (SK-MEL-5, SK-MEL-25), as well as in normal human melanocytes (NHM), along with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] treatment.	Vitamin D	87-96	clusterin	Homo sapiens	50-53
16886681-5	2006	Using PCR and Western blotting, the expression of CLU was also investigated in various vitamin D-responsive (MeWo, SK-MEL-28) and vitamin D-resistant melanoma cell lines (SK-MEL-5, SK-MEL-25), as well as in normal human melanocytes (NHM), along with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] treatment.	Vitamin D	130-139	clusterin	Homo sapiens	50-53
16476762-2	2006	Oestrogens, androgens, corticosteroids, parathyroid hormone (PTH), vitamin D, and several cytokines exert their effects on bone modulating the OPG/RANKL system.	Vitamin D	67-76	TNF receptor superfamily member 11b	Homo sapiens	143-146
16618780-0	2006	Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.	Vitamin D	21-30	dual specificity phosphatase 10	Homo sapiens	93-139
16618780-2	2006	Using normal human prostatic epithelial cells, we examined the role of mitogen-activated protein kinase phosphatase 5 (MKP5) in mediating cancer preventive activities of vitamin D.	Vitamin D	170-179	dual specificity phosphatase 10	Homo sapiens	71-117
16618780-2	2006	Using normal human prostatic epithelial cells, we examined the role of mitogen-activated protein kinase phosphatase 5 (MKP5) in mediating cancer preventive activities of vitamin D.	Vitamin D	170-179	dual specificity phosphatase 10	Homo sapiens	119-123
16618780-4	2006	We also identified a putative positive vitamin D response element within the MKP5 promoter that associated with the vitamin D receptor following 1,25D treatment.	Vitamin D	39-48	dual specificity phosphatase 10	Homo sapiens	77-81
16718398-11	2006	Therefore, the monitoring of vitamin D status--i.e. 25(OH)D and PTH--in Turkish immigrants is warranted and once a deficiency is identified, it should be appropriately treated.	Vitamin D	29-38	LOW QUALITY PROTEIN: parathyroid hormone	Meleagris gallopavo	64-67
16195230-7	2005	Both a Runx2 site (-136/-130) and the vitamin D response element (-757/-743) in the OPN promoter are needed for cooperative activation.	Vitamin D	38-47	secreted phosphoprotein 1	Mus musculus	84-87
16047647-3	2005	Little is known about the effects of vitamin D therapy on the circulating osteoprotegerin levels in dialysis patients.	Vitamin D	37-46	TNF receptor superfamily member 11b	Homo sapiens	74-89
16047647-10	2005	Osteoprotegerin may mediate and/or modify the effect of active vitamin D therapy in dialysis patients.	Vitamin D	63-72	TNF receptor superfamily member 11b	Homo sapiens	0-15
15781002-10	2005	The synthesis of 1,25D in bone tissue regulates bone CYP24 expression and is associated with bone mineralization suggesting that vitamin D metabolism has an autocrine or paracrine function.	Vitamin D	129-138	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	53-58
15280907-12	2005	CONCLUSIONS: There is widespread vitamin D deficiency in both men and women born in Turkey, Sri Lanka, Iran, Pakistan and Vietnam residing in Oslo.	Vitamin D	33-42	sorcin	Meleagris gallopavo	92-95
15327402-12	2004	This study indicates that Ca(2+) transport proteins, including TRPV5 and TRPV6, are differentially up-regulated by vitamin D compounds.	Vitamin D	115-124	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	63-68
15327402-12	2004	This study indicates that Ca(2+) transport proteins, including TRPV5 and TRPV6, are differentially up-regulated by vitamin D compounds.	Vitamin D	115-124	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	73-78
15178414-10	2004	Western blot analysis showed that the expression of androgen receptor (AR) protein was consistent with vitamin D(3) regulation of FACL3/ACS3 expression.	Vitamin D	103-112	acyl-CoA synthetase long chain family member 3	Homo sapiens	130-135
15178414-10	2004	Western blot analysis showed that the expression of androgen receptor (AR) protein was consistent with vitamin D(3) regulation of FACL3/ACS3 expression.	Vitamin D	103-112	acyl-CoA synthetase long chain family member 3	Homo sapiens	136-140
15178414-11	2004	Taken together, the data suggest that the upregulation of FACL3/ACS3 expression by vitamin D(3) is through an androgen/AR-mediated pathway and might be one of the contributions of the vitamin D(3) antiproliferative effect in prostate cancer LNCaP cells.	Vitamin D	83-92	acyl-CoA synthetase long chain family member 3	Homo sapiens	58-63
15178414-11	2004	Taken together, the data suggest that the upregulation of FACL3/ACS3 expression by vitamin D(3) is through an androgen/AR-mediated pathway and might be one of the contributions of the vitamin D(3) antiproliferative effect in prostate cancer LNCaP cells.	Vitamin D	83-92	acyl-CoA synthetase long chain family member 3	Homo sapiens	64-68
15178414-11	2004	Taken together, the data suggest that the upregulation of FACL3/ACS3 expression by vitamin D(3) is through an androgen/AR-mediated pathway and might be one of the contributions of the vitamin D(3) antiproliferative effect in prostate cancer LNCaP cells.	Vitamin D	184-193	acyl-CoA synthetase long chain family member 3	Homo sapiens	58-63
15178414-11	2004	Taken together, the data suggest that the upregulation of FACL3/ACS3 expression by vitamin D(3) is through an androgen/AR-mediated pathway and might be one of the contributions of the vitamin D(3) antiproliferative effect in prostate cancer LNCaP cells.	Vitamin D	184-193	acyl-CoA synthetase long chain family member 3	Homo sapiens	64-68
15200683-8	2004	Subsequent patch clamp electrophysiological analysis failed to detect hIK1 channel currents in keratinocytes, even those expressing substantial hIK1 mRNA in response to calcium and Vitamin D induced differentiation.	Vitamin D	181-190	potassium calcium-activated channel subfamily N member 4	Homo sapiens	144-148
15111121-4	2004	It was determined from substrate-induced spectral shifts that the 1 alpha- and 25-hydroxyl groups on vitamin D(3) metabolites and analogs were the major determinants for high-affinity binding to CYP24A1.	Vitamin D	101-110	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	195-202
15225744-7	2004	Based on these results, the enzyme responsible for the C-3 epimerization of Vitamin D3 are thought to be different from already-known cytochrome P450-related Vitamin D metabolic enzymes and HSE.	Vitamin D	76-85	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	190-193
15225792-2	2004	The epithelial calcium transporter, known as ECAC2 or CAT1, the product of the TRPV6 gene expressed in proximal intestinal enterocytes, is the first step in calcium absorption and studies in mice have shown that its expression is Vitamin D-dependent.	Vitamin D	230-239	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	45-50
15225792-2	2004	The epithelial calcium transporter, known as ECAC2 or CAT1, the product of the TRPV6 gene expressed in proximal intestinal enterocytes, is the first step in calcium absorption and studies in mice have shown that its expression is Vitamin D-dependent.	Vitamin D	230-239	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	54-58
15225792-2	2004	The epithelial calcium transporter, known as ECAC2 or CAT1, the product of the TRPV6 gene expressed in proximal intestinal enterocytes, is the first step in calcium absorption and studies in mice have shown that its expression is Vitamin D-dependent.	Vitamin D	230-239	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	79-84
15225808-6	2004	Further, pretreatment of cultured VSMC with the Vitamin D non-calcemic analog JK 1624 F2-2 (JKF) increased ERalpha mRNA (100-200%) but decreased ERbeta mRNA (30-40%) expression as measured by real time PCR.	Vitamin D	48-57	estrogen receptor 2	Homo sapiens	145-151
15225812-4	2004	Whereas, the expression of Msx2, another member of Msx family, has been shown to be controlled by Vitamin D, no information is available for Msx1.	Vitamin D	98-107	msh homeobox 2	Mus musculus	27-31
15036392-6	2004	Our previous studies have shown that the active form of vitamin D (1,25(OH)(2)D(3)) plays a role as a bone forming agent because it induces osteoblastogenesis and inhibits adipogenesis in bone marrow of SAM-P/6 mice.	Vitamin D	56-65	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Mus musculus	203-210
14511659-4	2003	Administration of vitamin D or CaCl(2) to wild-type mice causes upregulation of STC1 but STC2 gene expression is not altered significantly.	Vitamin D	18-27	stanniocalcin 1	Mus musculus	80-84
14511659-4	2003	Administration of vitamin D or CaCl(2) to wild-type mice causes upregulation of STC1 but STC2 gene expression is not altered significantly.	Vitamin D	18-27	stanniocalcin 2	Mus musculus	89-93
12697832-10	2003	On the basis of these results, we propose that p300 interacts with key transcriptional regulators of the OC gene and bridges distal and proximal OC promoter sequences to facilitate responsiveness to vitamin D(3).	Vitamin D	199-208	E1A binding protein p300	Homo sapiens	47-51
12508107-1	2003	Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites.	Vitamin D	122-131	LDL receptor related protein 2	Homo sapiens	0-7
12508107-1	2003	Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites.	Vitamin D	171-180	LDL receptor related protein 2	Homo sapiens	0-7
12520535-8	2003	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular ECaC2 or TRPV6) is strongly vitamin D dependent and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D dependent active calcium absorption.	Vitamin D	286-295	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	107-112
12520535-8	2003	These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular ECaC2 or TRPV6) is strongly vitamin D dependent and that calcium influx, probably interacting with calbindin-D(9K), should be considered as a rate-limiting step in the process of vitamin D dependent active calcium absorption.	Vitamin D	286-295	S100 calcium binding protein G	Mus musculus	206-220
12520537-6	2003	Discussed in this article is the action of the rat CYP24 to catalyze the side-chain oxidation and cleavage of 25-hydroxylated vitamin D metabolites.	Vitamin D	126-135	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	51-56
12778851-13	2003	CONCLUSIONS: Healthy men with higher levels of vitamin D have higher levels of SBP and DBP.	Vitamin D	47-56	selenium binding protein 1	Homo sapiens	79-82
12498308-4	2002	Hormonal responsiveness was characterized by measuring the capacity of 1,25-dihydroxyvitamin D [1,25(OH)2D], the hormonal form of vitamin D, to increase mRNA levels of the intestinal 24-hydroxylase cytochrome P-450 (CYP24).	Vitamin D	85-94	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	216-221
12097160-9	2002	In contrast, U937 cells treated with vitamin D(3) or all-trans retinoic acid showed Fas-resistance, and caspase-8 processing and FLIP cleavage were strongly inhibited.	Vitamin D	37-46	caspase 8	Homo sapiens	104-113
12218287-5	2002	All-trans-retinoic acid, dithranol and the p38 mitogen-activated protein (MAP) kinase inhibitor SB220025 displayed a strong inhibitory effect on SKALP expression while cyclosporin A, dexamethasone, the vitamin D(3) derivative calcipotriol and the p38 MAP kinase inhibitor SB203580 showed only moderate inhibition.	Vitamin D	202-211	peptidase inhibitor 3	Homo sapiens	145-150
11960621-3	2002	1 alpha,25(OH)(2)D(3) is conformationally flexible (side chain, seco B-ring and A-ring) and accordingly is able to generate a large array of different shapes to serve as ligands for available receptors (VDR(nuc) and VDR(mem)) in the vitamin D endocrine system.	Vitamin D	233-242	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	203-206
11997185-0	2002	Regulation of PTH-related protein gene expression by vitamin D in PC-3 prostate cancer cells.	Vitamin D	53-62	parathyroid hormone like hormone	Homo sapiens	14-33
11913978-1	2002	Calbindin (CaBP)-D9k is a major vitamin D target gene involved in calcium homeostasis.	Vitamin D	32-41	S100 calcium binding protein G	Mus musculus	11-20
11832333-4	2002	1,25-(OH)(2) vitamin D(3) treatment also increased NaP(i)-IIb mRNA abundance by approximately 2-fold in 14-day-old rats but had no effect on mRNA expression in adults.	Vitamin D	13-22	solute carrier family 34 member 2	Homo sapiens	51-61
11832333-5	2002	Furthermore, in rat intestinal epithelial (RIE) cells, 1,25-(OH)(2) vitamin D(3) increased NaP(i)-IIb mRNA abundance, an effect that was abolished by actinomycin D.	Vitamin D	68-77	solute carrier family 34 member 2	Homo sapiens	91-101
11832333-6	2002	Additionally, human NaP(i)-IIb gene promoter activity in transiently transfected RIE cells showed approximately 1.6-fold increase after 1,25-(OH)(2) vitamin D(3) treatment.	Vitamin D	149-158	solute carrier family 34 member 2	Homo sapiens	20-30
11679963-8	2001	Vitamin D reduced the concentration of IL-2 and IL-12 in serum and in grafts, and increased IL-4 and IL-10 in the grafts.	Vitamin D	0-9	interleukin 4	Rattus norvegicus	92-96
11382777-4	2001	A binding site, the vitamin D response element (VDRE), for a heterodimer of vitamin D receptor (VDR) and retinoic X receptor alpha (RXR alpha) within the slow MyHC3 promoter mediates chamber-specific expression of the gene.	Vitamin D	20-29	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	48-51
11302745-9	2001	Deletion of the SSA2, SSA3, and SSA4 genes and reduction of Ssa1p activity, reduces the intracellular concentrations of the VDR and its heterodimeric partner, RXRalpha and reduces the activity of a vitamin D-dependent gene.	Vitamin D	198-207	Hsp70 family chaperone SSA2	Saccharomyces cerevisiae S288C	16-20
11384862-1	2001	Vitamin D, parathyroid hormone (PTH), and parathyroid hormone-related peptide (PTHrP) are major regulators of calcium metabolism and vitamin D can also reduce the growth of normal cells and tumor cells.	Vitamin D	133-142	parathyroid hormone	Mus musculus	11-30
11384862-1	2001	Vitamin D, parathyroid hormone (PTH), and parathyroid hormone-related peptide (PTHrP) are major regulators of calcium metabolism and vitamin D can also reduce the growth of normal cells and tumor cells.	Vitamin D	133-142	parathyroid hormone	Mus musculus	32-35
11062020-2	2000	A candidate sequence for a vitamin D response element (VDRE) is present within a 1.7-kb promoter region of the human PMCA1 (hPMCA1) gene.	Vitamin D	27-36	ATPase plasma membrane Ca2+ transporting 1	Homo sapiens	117-122
11062020-2	2000	A candidate sequence for a vitamin D response element (VDRE) is present within a 1.7-kb promoter region of the human PMCA1 (hPMCA1) gene.	Vitamin D	27-36	ATPase plasma membrane Ca2+ transporting 1	Homo sapiens	124-130
10697495-0	1999	In vivo nuclear uptake of a vitamin D analog (OCT) in different tumor cell populations of FA-6 cancer xenograft in nude mice by receptor autoradiography.	Vitamin D	28-37	plexin A2	Mus musculus	46-49
10525058-2	1999	Western blot analysis revealed that reduction of cyclin D1 levels is a key mechanism by which the vitamin D compounds under investigation inhibit Caco-2 tumor cell growth.	Vitamin D	98-107	cyclin D1	Homo sapiens	49-58
10485982-14	1999	In short, it is clear that some form of vitamin D therapy, either plain vitamin D or 1,25(OH)(2)D(3) or 1alpha(OH)D(3), can be used to correct all types of age-dependent impairments in intestinal Ca absorption and secondary hyperparathyroidism during aging.	Vitamin D	40-49	opioid receptor delta 1	Homo sapiens	80-86
10441383-9	1999	Recently, it was found that 1alpha,25(OH)(2)D(3)-24-hydroxylase (CYP24) can hydroxylate carbons 23, 24, and 26 of various vitamin D(3) compounds.	Vitamin D	122-131	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	65-70
10417310-8	1999	We show in gel-shift assays that the sequence within a putative vitamin-D-response element in the human calbindin-D9k promoter can bind expressed IPF-1/PDX-1 protein, although we cannot confirm binding of the vitamin-D-receptor protein.	Vitamin D	64-73	pancreatic and duodenal homeobox 1	Homo sapiens	152-157
15251676-9	1999	CONCLUSION: This case suggests that PTHrP stimulation of the parathyroid hormone-PTHrP receptor during lactation may compensate for the absence of parathyroid hormone in lactating women with hypoparathyroidism and that treatment with pharmacologic doses of vitamin D preparations during the postpartum period may result in hypercalcemia.	Vitamin D	257-266	parathyroid hormone like hormone	Homo sapiens	36-41
15251676-9	1999	CONCLUSION: This case suggests that PTHrP stimulation of the parathyroid hormone-PTHrP receptor during lactation may compensate for the absence of parathyroid hormone in lactating women with hypoparathyroidism and that treatment with pharmacologic doses of vitamin D preparations during the postpartum period may result in hypercalcemia.	Vitamin D	257-266	parathyroid hormone like hormone	Homo sapiens	81-86
10037600-4	1999	Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.	Vitamin D	43-52	SMAD family member 3	Homo sapiens	6-11
10671148-0	1999	[Role and physiologic importance of megalin in the internalization of vitamin D by endocytosis at the luminal pole of the proximal convoluted tubule].	Vitamin D	70-79	LDL receptor related protein 2	Homo sapiens	36-43
9820625-2	1998	Insulin-like growth factor-I (IGF-I) was recently reported to be a regulator of renal 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) production, suggesting that it mediates the effects of GH on vitamin D metabolism.	Vitamin D	100-109	insulin like growth factor 1	Sus scrofa	0-28
9820625-2	1998	Insulin-like growth factor-I (IGF-I) was recently reported to be a regulator of renal 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) production, suggesting that it mediates the effects of GH on vitamin D metabolism.	Vitamin D	100-109	insulin like growth factor 1	Sus scrofa	30-35
9824486-0	1998	Vitamin D differentially regulates B7.1 and B7.2 expression on human peripheral blood monocytes.	Vitamin D	0-9	CD80 molecule	Homo sapiens	35-39
9784422-8	1998	Because it is expressed in various types of human osteoblastic cells, and is stimulated by vitamin D, BMP-2 and cytokines, OPG may be an important paracrine modulator of bone remodeling.	Vitamin D	91-100	TNF receptor superfamily member 11b	Homo sapiens	123-126
9717845-0	1998	Calreticulin inhibits vitamin D"s action on the PTH gene in vitro and may prevent vitamin D"s effect in vivo in hypocalcemic rats.	Vitamin D	22-31	calreticulin	Rattus norvegicus	0-12
9717845-0	1998	Calreticulin inhibits vitamin D"s action on the PTH gene in vitro and may prevent vitamin D"s effect in vivo in hypocalcemic rats.	Vitamin D	82-91	calreticulin	Rattus norvegicus	0-12
9717845-8	1998	Gel shift assays showed that a purified vitamin D receptor and retinoid X receptor-beta bound to the PTH promoter"s chicken and rat vitamin D response element (VDRE), and this binding was inhibited by added pure calreticulin.	Vitamin D	40-49	calreticulin	Rattus norvegicus	212-224
9558335-1	1998	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D, induces nerve growth factor (NGF) synthesis in a variety of different cell lines.	Vitamin D	14-23	nerve growth factor	Rattus norvegicus	84-103
9558335-1	1998	1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D, induces nerve growth factor (NGF) synthesis in a variety of different cell lines.	Vitamin D	14-23	nerve growth factor	Rattus norvegicus	105-108
9356223-9	1997	Because VDR were richer in the shell gland than in other oviductal segments, these results suggest that in laying hens the shell gland tissues are one of the significant targets for vitamin D.	Vitamin D	182-191	vitamin D (1,25- dihydroxyvitamin D3) receptor	Gallus gallus	8-11
9282324-14	1997	By studying analogues with greatly reduced affinity for the VDR, we have provided further evidence for the existence of a membrane receptor(s) involved in mediating nongenomic effects of vitamin D metabolites.	Vitamin D	187-196	vitamin D receptor	Bos taurus	60-63
9210418-9	1997	Vitamin D responsiveness of the NaPi-3 promoter was also detected in COS-7 cells co-transfected with a human vitamin D receptor expression vector.	Vitamin D	0-9	solute carrier family 34 member 1	Homo sapiens	32-38
9143355-1	1997	The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes.	Vitamin D	89-98	secreted phosphoprotein 1	Mus musculus	235-246
9143355-1	1997	The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes.	Vitamin D	89-98	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	252-287
9048346-7	1997	Employing electrophoretic mobility shift assay, we consistently observed a significant reduction in kidney calcitriol-receptor complex binding to mouse osteopontin vitamin D response element (-70.2 +/- 4.9%, P &lt; 0.001).	Vitamin D	164-173	secreted phosphoprotein 1	Mus musculus	152-163
9010343-1	1996	The nature of the DNA binding interactions of the human vitamin D receptor (hVDR) with the murine osteopontin vitamin D response element (mOP VDRE) was examined.	Vitamin D	56-65	secreted phosphoprotein 1	Mus musculus	98-109
8936593-1	1996	Rev-erb beta is a member of the nuclear receptor superfamily, which includes a group of transcription factors involved in the response to steroids, vitamin D, retinoic acids, and other lipophilic molecules.	Vitamin D	148-157	nuclear receptor subfamily 1 group D member 2	Homo sapiens	0-12
8883959-4	1996	Putative vitamin D responsive elements (VDRE) in the P75NTR promoter have been investigated by transfecting plasmids containing sequences from P75NTR promoter fused to a cat reporter gene.	Vitamin D	9-18	nerve growth factor receptor	Rattus norvegicus	53-59
8694856-6	1996	Our results suggest that the dual effect of 1,25-(OH)2D3 on hsp28 and PKC beta gene expression is due to the different sequence composition of the vitamin D response element in the promoter region as well as an accessory factor for each gene or that 1,25-(OH)2D3 increases PKC beta gene expression, which, in turn, negatively regulates the expression of the hsp28 gene or vice versa.	Vitamin D	147-156	protein kinase C beta	Homo sapiens	70-78
8694856-6	1996	Our results suggest that the dual effect of 1,25-(OH)2D3 on hsp28 and PKC beta gene expression is due to the different sequence composition of the vitamin D response element in the promoter region as well as an accessory factor for each gene or that 1,25-(OH)2D3 increases PKC beta gene expression, which, in turn, negatively regulates the expression of the hsp28 gene or vice versa.	Vitamin D	147-156	protein kinase C beta	Homo sapiens	273-281
8760262-3	1996	Here we have examined the effects of dietary Pi on the expression of the renal vitamin D-24-hydroxylase (24-OHase), the first enzyme in the catabolic pathway for vitamin D compounds.	Vitamin D	79-88	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	105-113
9011759-5	1996	Combined treatment with 1,25(OH)2 D3 and 20 microM nicotine had no additive effect on TH mRNA levels suggesting that transsynaptic (nicotinic) and vitamin D (hormonal) stimulation of TH gene expression are mediated through converging mechanisms.	Vitamin D	147-156	tyrosine hydroxylase	Mus musculus	183-185
7588278-10	1995	The vitamin D-regulated osteopontin gene was induced 4 h after the administration of RA regardless of retinoid or vitamin D status.	Vitamin D	4-13	secreted phosphoprotein 1	Rattus norvegicus	24-35
7649106-0	1995	Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin, Ca,Mg-adenosine triphosphatase, and 25-hydroxyvitamin D3 24-hydroxylase): implications for differing mechanisms of regulation and involvement of multiple factors.	Vitamin D	35-44	secreted phosphoprotein 1	Rattus norvegicus	62-73
7649106-8	1995	However, in vitamin D-replete rats given 1,25-(OH)2D3 for 5 days, a significant induction in renal OPN was observed (6.0-fold; P &lt; 0.01).	Vitamin D	12-21	secreted phosphoprotein 1	Rattus norvegicus	99-102
7667104-9	1995	We further showed that overexpression of calreticulin in the rat osteoblast-like cell line (ROS 17/2.8) inhibited the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] responsive transcriptional activation of a vitamin D-sensitive reporter gene, whereas the response to forskolin stimulation of a control promoter-reporter construct containing a cAMP response element (CRE), but no vitamin D response element (VDRE), was not affected by overexpression of calreticulin.	Vitamin D	132-141	calreticulin	Rattus norvegicus	41-53
7667104-9	1995	We further showed that overexpression of calreticulin in the rat osteoblast-like cell line (ROS 17/2.8) inhibited the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] responsive transcriptional activation of a vitamin D-sensitive reporter gene, whereas the response to forskolin stimulation of a control promoter-reporter construct containing a cAMP response element (CRE), but no vitamin D response element (VDRE), was not affected by overexpression of calreticulin.	Vitamin D	200-209	calreticulin	Rattus norvegicus	41-53
8536074-1	1995	Calbindin-D9k (CaBP9k) is a vitamin D-dependent, calcium binding protein first identified in the cytoplasm of the intestinal epithelial cell.	Vitamin D	28-37	S100 calcium binding protein G	Bos taurus	0-13
7607559-2	1995	Screening of a vitamin-D-deficient chick kidney library resulted in the isolation of a 450-bp cDNA clone encoding the 76-amino acid (aa) protein kinase inhibitor (PKI).	Vitamin D	15-24	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	137-161
7607559-2	1995	Screening of a vitamin-D-deficient chick kidney library resulted in the isolation of a 450-bp cDNA clone encoding the 76-amino acid (aa) protein kinase inhibitor (PKI).	Vitamin D	15-24	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	Gallus gallus	163-166
21153232-8	1995	These observations suggest that PTN expression in osteoblasts is regulated by the calcitropic hormone, 1,25(OH)(2)D(3), and that PTN may play a role in vitamin D-dependent regulation of bone metabolism.	Vitamin D	152-161	pleiotrophin	Rattus norvegicus	129-132
8144641-8	1994	These results indicate that a direct repeat motif, AGGTGAgt-gAGGGCG, located at -151 base pairs upstream in the antisense strand binds to a heterologous dimer consisting of the VDR occupied with 1,25-(OH)2D3 and the nuclear accessory factor and that it plays a critical role in mediating the vitamin D enhancement of the rat P450cc24 gene expression.	Vitamin D	292-301	vitamin D receptor	Rattus norvegicus	177-180
8119143-9	1994	Northern analysis demonstrates that beta 3 mRNA levels in vitamin D-treated osteoclast precursors mirror protein expression.	Vitamin D	58-67	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	36-42
8015545-7	1994	We find that the purified receptor selects a heptameric sequence resembling a half-site of the osteopontin vitamin D response element, consistent with osteopontin-like sequences acting as high affinity targets for hVDR in the absence of RXR.	Vitamin D	107-116	secreted phosphoprotein 1	Homo sapiens	95-106
8311449-8	1994	Our results are the first demonstration of vitamin D-regulated calbindin mRNA in a human intestinal cell line.	Vitamin D	43-52	calbindin 1	Homo sapiens	63-72
7700214-7	1994	Vitamin D treatment raised the levels of calbindin-D9k in the normomagnesemic group (p &lt; 0.01), but not significantly in the low Mg group.	Vitamin D	0-9	S100 calcium binding protein G	Rattus norvegicus	41-54
8229291-2	1993	Impaired development was observed in normocalcemic, vitamin D-deficient male and female rats, as revealed by low intestinal calcium transport, low renal vitamin D receptor levels and poor bone mineralization.	Vitamin D	52-61	vitamin D receptor	Rattus norvegicus	153-171
8229292-9	1993	These results indicate that dietary AlCl3 inhibits vitamin D-dependent Ca absorption by reducing the amount of intestinal calbindin D-28K.	Vitamin D	51-60	calbindin 1	Homo sapiens	122-131
8396012-13	1993	Furthermore, comparison of the transient elevation of calcium absorption by OCT with its more prolonged effects on PTH and calbindin D9k indicates that each action of vitamin D compounds has a distinct biological half-life.	Vitamin D	167-176	S100 calcium binding protein G	Rattus norvegicus	123-136
8394351-10	1993	In combination with all-trans-retinoic acid, however, vitamin D enhances VDR-RAR heterodimer-mediated gene expression.	Vitamin D	54-63	retinoic acid receptor alpha	Homo sapiens	77-80
1628219-1	1992	The localization of the vitamin D-dependent calcium-binding protein, calbindin D-28k (CaBP), was studied immunocytochemically in rat striated muscle.	Vitamin D	24-33	S100 calcium binding protein G	Rattus norvegicus	86-90
1622141-3	1992	The proliferative stimulus of IL-3 overrode and reversed the antiproliferative actions of both RA and vitamin D, the latter being more sensitive to the counter-acting effect of IL-3.	Vitamin D	102-111	interleukin 3	Homo sapiens	30-34
1584219-0	1992	Local chromatin changes accompany the expression of the calbindin-D28K gene: tissue specificity and effect of vitamin D activation.	Vitamin D	110-119	calbindin 1	Homo sapiens	56-65
1515278-0	1992	Recombinant human GM-CSF enhances the anti-proliferative activity of vitamin D in MCF-7 human breast cancer clonogenic cells.	Vitamin D	69-78	colony stimulating factor 2	Homo sapiens	18-24
1777592-1	1991	There is strong evidence that vitamin D-dependent Ca(2+)-binding proteins, i.e., calbindin-D9k and calbindin-D28k, facilitate diffusion of Ca2+ through the cytosolic compartment of renal and intestinal cells, which transport Ca2+ transcellularly.	Vitamin D	30-39	S100 calcium binding protein G	Rattus norvegicus	81-94
1655516-1	1991	We report that receptors for vitamin D exist in distinct regions of the heart in female and male mice, predominantly in the right atrium where most of the cardial atrial natriuretic peptide (ANF) is produced.	Vitamin D	29-38	natriuretic peptide type A	Mus musculus	191-194
1655516-3	1991	Changes of ANF tissue and blood levels under dietary deficiency and treatment with 1,25-D3 suggest direct genomic actions of vitamin D on myoendocrine cells of the atrium for the regulation of ANF manufacture and secretion.	Vitamin D	125-134	natriuretic peptide type A	Mus musculus	11-14
2035635-4	1991	Lung, bladder, and especially prostate demonstrated 45Ca2+ bands comigrating with the intestinal vitamin D-related CaBP (CaBP-D9K; mol mass = 10.9 +/- 0.5 kDa).	Vitamin D	97-106	S100 calcium binding protein G	Rattus norvegicus	115-119
2035635-4	1991	Lung, bladder, and especially prostate demonstrated 45Ca2+ bands comigrating with the intestinal vitamin D-related CaBP (CaBP-D9K; mol mass = 10.9 +/- 0.5 kDa).	Vitamin D	97-106	S100 calcium binding protein G	Rattus norvegicus	121-129
2035635-9	1991	Immunoblot analysis of the 9-kDa CaBP in lung further confirmed its vitamin D independence.	Vitamin D	68-77	S100 calcium binding protein G	Rattus norvegicus	33-37
2035638-0	1991	Intestinal vitamin D-dependent calbindin-D9k and alkaline phosphatase in spontaneously hypertensive rats.	Vitamin D	11-20	S100 calcium binding protein G	Rattus norvegicus	31-44
2001709-2	1991	Calbindin is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin and calretinin is poorly understood.	Vitamin D	41-50	calbindin 1	Homo sapiens	0-9
2161536-0	1990	Serum calcium and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in rat kidney in vivo.	Vitamin D	18-27	vitamin D receptor	Rattus norvegicus	37-70
2161536-8	1990	This study demonstrates that serum calcium levels and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in vivo in kidney.	Vitamin D	54-63	vitamin D receptor	Rattus norvegicus	73-106
2158960-0	1990	Salmon calcitonin as adjunct treatment for vitamin D toxicosis in a dog.	Vitamin D	43-52	calcitonin	Canis lupus familiaris	7-17
2158960-2	1990	This report shows that the rodenticide is toxic to dogs and that salmon calcitonin is a useful treatment for the often refractory hypercalcemia induced by vitamin D toxicosis.	Vitamin D	155-164	calcitonin	Canis lupus familiaris	72-82
33939949-0	2021	Associations between FTO rs9939609 polymorphism, serum vitamin D, mental health, and eating behaviors in overweight adults.	Vitamin D	55-64	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	21-24
33939949-2	2021	Besides, vitamin D deficiency and obesity are mostly seen together, and it can be hypothesized that this nutrient may have an impact in the role of FTO genotype in adiposity.Objective: Thus, this study aimed to investigate the association of FTO rs9939609 gene polymorphism with eating behaviors, eating disorders, and general mental health in overweight adults, considering their vitamin D intake as a mediate confounding factor.Methods: This cross-sectional study was carried out on 197 overweight adults in Shiraz, Iran.	Vitamin D	381-390	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	148-151
33939949-4	2021	Mental health, vitamin D intake, eating behaviors and disorders were assessed by the validated questionnaires.Results: The risk allele of the FTO rs9939609 polymorphism (A) was significantly associated with a higher risk of eating behavior and mental health disorders (all P < 0.05).	Vitamin D	15-24	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	142-145
33939949-6	2021	It was also identified that the effect of FTO rs9939609 A risk allele on eating behavior and mental health may be limited to people with insufficient vitamin D intake.	Vitamin D	150-159	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	42-45
33940646-2	2021	Hepcidin expression is suppressed by vitamin D.	Vitamin D	37-46	hepcidin antimicrobial peptide	Homo sapiens	0-8
33771629-0	2021	PARACOCCIDIOIDES brasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro.	Vitamin D	77-86	interleukin 32	Homo sapiens	71-76
34734656-0	2022	Vitamin D Inhibits the Early Aggregation of alpha-Synuclein and Modulates Exocytosis Revealed by Electrochemical Measurements.	Vitamin D	0-9	synuclein alpha	Homo sapiens	44-59
34948139-8	2021	Moreover, oral therapy with active forms of vitamin D suppressed arthritis in LAIR-1 sufficient DR1 mice, but were ineffective in LAIR-1-/- deficient mice.	Vitamin D	44-53	leukocyte-associated Ig-like receptor 1	Mus musculus	78-84
34948139-9	2021	Taken together, these data show that the effect of vitamin D on inflammation is at least, in part, mediated by LAIR-1 and that non-calcemic 20S(OH)D3 may be a promising therapeutic agent for the treatment of autoimmune diseases such as Rheumatoid Arthritis.	Vitamin D	51-60	leukocyte-associated Ig-like receptor 1	Mus musculus	111-117
34925313-3	2021	Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR).	Vitamin D	12-21	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	47-53
34853015-7	2021	In the microencapsulated vitamin D group, there was a decrease in IRI serum levels (p=0.023), HOMA-IR (p=0.021), serum AMH (p=0.010) and testosterone levels (p=0.006).	Vitamin D	25-34	anti-Mullerian hormone	Homo sapiens	119-122
34192357-6	2021	We found that these vitamin D effects were accompanied by decreased NF-kappaB (p65) in the knockout intestinal epithelia, reduced tissue-resident macrophages, and partial restoration of epithelial morphology.	Vitamin D	20-29	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	79-82
34297067-0	2021	Bone turnover in pregnancy, measured by urinary C-terminal telopeptide of type I collagen (CTX), is influenced by vitamin D supplementation and is associated with maternal bone health: Findings from the MAVIDOS trial.	Vitamin D	114-123	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	91-94
34769269-2	2021	Vitamin D derivatives with high VDR affinity and resistance to CYP24A1-mediated metabolism could be good therapeutic agents.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	32-35
34769269-6	2021	Vdr-gene-deficient rats can be used to assess the activities of vitamin D derivatives specialized for actions not mediated by VDR.	Vitamin D	64-73	vitamin D receptor	Rattus norvegicus	0-3
34769269-7	2021	One of our original vitamin D derivatives, which displays high affinity VDR binding and resistance to CYP24A1-dependent metabolism, has shown good therapeutic effects in Vdr (R270L) rats, although further analysis is needed.	Vitamin D	20-29	vitamin D receptor	Rattus norvegicus	72-75
34769269-7	2021	One of our original vitamin D derivatives, which displays high affinity VDR binding and resistance to CYP24A1-dependent metabolism, has shown good therapeutic effects in Vdr (R270L) rats, although further analysis is needed.	Vitamin D	20-29	vitamin D receptor	Rattus norvegicus	170-173
34490746-0	2021	The association between fat mass and obesity-associated (FTO) genotype and serum vitamin D level in breast cancer patients.	Vitamin D	81-90	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	57-60
34490746-2	2021	This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients.	Vitamin D	78-87	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	92-95
34490746-6	2021	The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders.	Vitamin D	24-33	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	42-45
34603404-0	2021	Corrigendum: Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.	Vitamin D	37-46	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	60-66
34503396-11	2022	It is possible that miR-146a may be associated with vitamin D deficiency and disease disability, while miR-155 may be associated with the number of attacks.	Vitamin D	52-61	microRNA 146a	Homo sapiens	20-28
34509882-9	2021	Most significantly, vitamin D fortified diet increased percent survival in KO animals and decreased the level of microglia marker IBA-1 and mTOR (mammalian target of rapamycin) downstream targets pS6 and pAKT.	Vitamin D	20-29	allograft inflammatory factor 1	Homo sapiens	130-135
34578986-9	2021	Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies.	Vitamin D	243-252	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	18-24
34578986-9	2021	Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies.	Vitamin D	243-252	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	157-163
34081342-9	2021	Vitamin D deficiency and insufficiency were more prevalent in LN patients than in controls, being significantly associated with disease activity and inversely associated with PD-1/PD-L1 expressions.	Vitamin D	0-9	CD274 molecule	Homo sapiens	180-185
34461991-1	2021	BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.	Vitamin D	91-100	secretoglobin family 1A member 1	Homo sapiens	151-155
34461991-1	2021	BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.	Vitamin D	91-100	secretoglobin family 1A member 1	Homo sapiens	167-171
34399781-6	2021	The results of linear regression on the relationship between 25-OH-vitamin D serum level and FTO and IRX3 genes expression based on FTO genotypes for rs9930506 indicated that in AA/AG genotype carriers, serum 25-OH-vitamin D level was positively associated with FTO gene expression (B = 0.07, p = 0.02) and inversely associated with IRX3 gene expression (B = - 0.07, p = 0.03).	Vitamin D	215-224	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	93-96
34399781-6	2021	The results of linear regression on the relationship between 25-OH-vitamin D serum level and FTO and IRX3 genes expression based on FTO genotypes for rs9930506 indicated that in AA/AG genotype carriers, serum 25-OH-vitamin D level was positively associated with FTO gene expression (B = 0.07, p = 0.02) and inversely associated with IRX3 gene expression (B = - 0.07, p = 0.03).	Vitamin D	215-224	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	262-265
34400742-8	2021	We also showed that treatment of bleomycin-induced vitamin D-deficient mice with AT1R antagonist losartan relieved weight loss, substantially ameliorated lung fibrosis and markedly blocked TGF-beta induction in the lung.	Vitamin D	51-60	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
34102194-0	2021	Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10alpha, TGF-beta and NRF-1 crosstalk.	Vitamin D	0-9	notch receptor 1	Rattus norvegicus	106-112
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Vitamin D	14-23	notch receptor 1	Rattus norvegicus	98-104
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Vitamin D	14-23	catenin beta 1	Rattus norvegicus	121-133
34137732-3	2021	Recently, CYP2R1 has been reported as a major factor for 25-hydroxylation contributing to the inherited forms of vitamin D deficiency.	Vitamin D	113-122	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	10-16
34371843-7	2021	Vitamin D intake was related to the loss of muscle mass after adjusting for sex, age, exercise, alcohol, smoking, body mass index, SMI, glucagon-like peptide-1 agonist, sodium glucose cotransporter-2 inhibitor, insulin, HbA1c, creatinine, energy intake, and protein intake (adjusted odds ratio 0.93, 95% confidence interval: 0.88-0.97, p = 0.003).	Vitamin D	0-9	solute carrier family 5 member 2	Homo sapiens	169-199
34281061-3	2021	In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Vitamin D	26-35	interleukin 1 alpha	Homo sapiens	103-111
34759613-0	2021	Does the Serum Vitamin D Status and its Possible Effect on Serum Anti-Mullerian Hormone Levels Predict Fertility in Premenopausal Women?	Vitamin D	15-24	anti-Mullerian hormone	Homo sapiens	65-87
34759613-2	2021	However, clinical studies have reported conflicting evidence on the effect of serum Vitamin D levels on serum Anti-Mullerian hormone (AMH), with little evidence in African women.	Vitamin D	84-93	anti-Mullerian hormone	Homo sapiens	110-132
34759613-2	2021	However, clinical studies have reported conflicting evidence on the effect of serum Vitamin D levels on serum Anti-Mullerian hormone (AMH), with little evidence in African women.	Vitamin D	84-93	anti-Mullerian hormone	Homo sapiens	134-137
34759613-3	2021	Aim: The study aimed to compare the relationship between serum Vitamin D and serum AMH among infertile and fertile women.	Vitamin D	63-72	anti-Mullerian hormone	Homo sapiens	83-86
34634848-1	2021	OBJECTIVES: The primary objective of this study was to define the relationship between vitamin D levels and interleukins (IL) 1beta and 6 as inflammatory markers in a healthy population.	Vitamin D	87-96	interleukin 1 alpha	Homo sapiens	108-131
34225429-10	2021	Results: Long-term vitamin D deficiency had increased acute liver failure sensitivity in mice, which was manifested by increased blood cell extravasation, massive necrosis of parenchymal cells, up-regulation of TNF-alpha, IL-1beta, and NLRP-3 mRNA expression (P < 0.05), and increased macrophages quantitation (P < 0.05) in liver tissues.	Vitamin D	19-28	interleukin 1 alpha	Mus musculus	222-230
34225429-10	2021	Results: Long-term vitamin D deficiency had increased acute liver failure sensitivity in mice, which was manifested by increased blood cell extravasation, massive necrosis of parenchymal cells, up-regulation of TNF-alpha, IL-1beta, and NLRP-3 mRNA expression (P < 0.05), and increased macrophages quantitation (P < 0.05) in liver tissues.	Vitamin D	19-28	NLR family, pyrin domain containing 3	Mus musculus	236-242
34225429-12	2021	On the contrary, pre-administration of high dose of vitamin D (100 IU/g) had significantly reduced liver injury, inhibited ALT and AST rise (P < 0.01), alleviated liver necrosis, and down-regulated the mRNA expression of inflammatory factors in liver tissues (P < 0.05).	Vitamin D	52-61	glutamic pyruvic transaminase, soluble	Mus musculus	123-126
35526493-9	2022	Sub-optimal vitamin D levels were implicated in disrupted reproductive hormone balance, including overproduction of anti-mullerian hormone (AMH); accumulation of pro-inflammatory Advanced Glycation End Products (AGEs) and formation of Reactive Oxygen Species (ROS) in ovarian tissue, leading to abnormal folliculogenesis.	Vitamin D	12-21	anti-Mullerian hormone	Homo sapiens	140-143
35549796-11	2022	FTO rs9939609 effects are more pronounced among children with insufficient vitamin D levels.	Vitamin D	75-84	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	0-3
35510872-0	2022	A long non-coding RNA as a direct vitamin D target transcribed from the anti-sense strand of the human HSD17B2 locus.	Vitamin D	34-43	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	103-110
35619053-6	2022	Early life vitamin D deficiency is associated with altered methylation of osterix and Runx2 in these bones.	Vitamin D	11-20	runt related transcription factor 2	Mus musculus	86-91
35582969-1	2022	BACKGROUND: Fetal stage is a critical developmental window for the skeletal muscle, but little information is available about the impact of maternal vitamin D (Vit.	Vitamin D	149-158	vitrin	Rattus norvegicus	160-163
35500429-8	2022	The levels of IL-1beta, TNF-alpha, and NF-kB p65 in knee OA patients with vitamin D insufficiency were significantly higher compared with the knee OA patients with sufficient vitamin D (P < 0.05).	Vitamin D	74-83	interleukin 1 alpha	Homo sapiens	14-22
35500429-9	2022	Based on the linear regression analysis, serum vitamin D levels were inversely correlated with IL-1beta, TNF-alpha, hs-CRP, and NF-kB p65 levels (P < 0.0001).	Vitamin D	47-56	interleukin 1 alpha	Homo sapiens	95-103
35370605-0	2022	Mediation Effects of IL-1beta and IL-18 on the Association Between Vitamin D Levels and Mild Cognitive Impairment Among Chinese Older Adults: A Case-Control Study in Taiyuan, China.	Vitamin D	67-76	interleukin 1 alpha	Homo sapiens	21-29
34694953-2	2022	In this case, the application of topical treatments in the first-line setting is recommended in most cases.Among different topical options, the fixed-dose combination of betamethasone dipropionate (BD) and vitamin D analogue (Cal) aerosol foam (Enstilar , Leo Pharma) is approved as first-line topical therapy for the treatment of psoriasis in USA and the EU, due to its high efficacy and its favorable administration scheme.The PSO-LONG was the first trial to report on the long-term efficacy and safety of the Cal/DB foam treatment for the proactive management of psoriasis and now, the indications of Cal/BD foam included its use in the psoriasis maintenance treatment.	Vitamin D	206-215	filamin binding LIM protein 1	Homo sapiens	226-229
35309341-7	2022	IL-32gamma is essential for the vitamin D-dependent microbicidal pathway for parasite control.	Vitamin D	32-41	interleukin 32	Homo sapiens	0-10
35242513-0	2022	The effect of vitamin D deficiency on the RANKL/OPG ratio in rats.	Vitamin D	14-23	TNF receptor superfamily member 11B	Rattus norvegicus	48-51
35242513-1	2022	The aim of this study was to determine the effect of vitamin D deficiency on the RANKL/OPG ((Receptor Activator of Nuclear Factor Kappa B Ligand/Osteoprotegerin) ratio in the serum blood levels.	Vitamin D	53-62	TNF receptor superfamily member 11B	Rattus norvegicus	87-90
35242513-1	2022	The aim of this study was to determine the effect of vitamin D deficiency on the RANKL/OPG ((Receptor Activator of Nuclear Factor Kappa B Ligand/Osteoprotegerin) ratio in the serum blood levels.	Vitamin D	53-62	TNF receptor superfamily member 11B	Rattus norvegicus	145-160
35242513-6	2022	The serum RANKL levels and RANKL/OPG ratio in rats, were negatively affected by the deficiency of vitamin D.	Vitamin D	98-107	TNF receptor superfamily member 11B	Rattus norvegicus	33-36
34982186-1	2022	Apart from a role as a key regulator of calcium/phosphate homeostasis, vitamin D (Vit D) is suggested to be a potential player in nervous system growth and function.	Vitamin D	71-80	vitrin	Rattus norvegicus	82-85
35371638-1	2022	X-linked hypophosphatemia (XLH), also referred to as vitamin D-resistant rickets or X-linked dominant hypophosphatemic rickets, is a very rare metabolic disorder.	Vitamin D	53-62	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	0-25
35371638-1	2022	X-linked hypophosphatemia (XLH), also referred to as vitamin D-resistant rickets or X-linked dominant hypophosphatemic rickets, is a very rare metabolic disorder.	Vitamin D	53-62	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	27-30
35147111-5	2022	The AFC and AMH, 25(OH)D, 1,25(OH)D, phosphate (P < .01), and calcium levels (P < .05) were statistically significantly increased after vitamin D supplementation.	Vitamin D	136-145	anti-Mullerian hormone	Homo sapiens	12-15
35120577-8	2022	METHODS: As the trial design, a randomized, placebo-controlled, double-blind, multi-center approach was chosen to compare a high single dose of vitamin D (140,000 IU) followed by treatment as usual (TAU) (VitD + TAU) with treatment as usual only (placebo + TAU) in patients with COVID-19 and vitamin D deficiency.	Vitamin D	144-153	microtubule associated protein tau	Homo sapiens	212-215
35120577-8	2022	METHODS: As the trial design, a randomized, placebo-controlled, double-blind, multi-center approach was chosen to compare a high single dose of vitamin D (140,000 IU) followed by treatment as usual (TAU) (VitD + TAU) with treatment as usual only (placebo + TAU) in patients with COVID-19 and vitamin D deficiency.	Vitamin D	144-153	microtubule associated protein tau	Homo sapiens	257-260
35120051-4	2022	The Seasonal Variation Calculator predicted winter vitamin D concentrations (8 +- 18 ng mL-1) higher than actual winter vitamin D concentrations (P < 0.01).	Vitamin D	51-60	L1 cell adhesion molecule	Mus musculus	88-92
2543194-6	1989	Highly correlated with the rate of calcium absorption under a wide variety of conditions is the concentration of the vitamin D-induced calcium-binding protein, calbindin-D28K (avian type) and calbindin-D9K (mammalian intestinal type).	Vitamin D	117-126	calbindin 1	Homo sapiens	160-169
3342759-5	1988	Inhibition of phospholipase-A with bromophenacylbromide blocks the vitamin D effect on cytosolic calcium, indicating that phospholipase-A activation precedes increments in cytosolic calcium.	Vitamin D	67-76	phospholipase A and acyltransferase 1	Homo sapiens	14-29
3342759-5	1988	Inhibition of phospholipase-A with bromophenacylbromide blocks the vitamin D effect on cytosolic calcium, indicating that phospholipase-A activation precedes increments in cytosolic calcium.	Vitamin D	67-76	phospholipase A and acyltransferase 1	Homo sapiens	122-137
2445747-1	1987	Regulation of the expression of vitamin D-dependent calcium-binding protein (Mr 9000 CaBP) gene by 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) was studied in the rat duodenum.	Vitamin D	32-41	S100 calcium binding protein G	Rattus norvegicus	85-89
2445747-3	1987	A single 1,25-(OH)2D3 injection (650 pmol/100 g of body weight) induced a 2-fold increase in Mr 9000 CaBP gene transcription within 15 min in the duodenum of vitamin D-deficient rats.	Vitamin D	158-167	S100 calcium binding protein G	Rattus norvegicus	101-105
3449006-4	1987	Electron microscopic localization of PEP-19-like immunoreactivity reveals similarities between this polypeptide, parvalbumin, and a 28K vitamin D-dependent calcium binding protein.	Vitamin D	136-145	Purkinje cell protein 4	Mus musculus	37-43
3035148-5	1987	Similarly, nine tissues express the vitamin D-induced calbindin; seven have been reported in avian tissues.	Vitamin D	36-45	calbindin 1	Homo sapiens	54-63
3027219-3	1987	IL-2 production was two fold higher from MLA-144 cells cultured in 2% vitamin D-deficient rat serum compared to 10% fetal calf serum (FCS).	Vitamin D	70-79	interleukin 2	Mus musculus	0-4
3027219-4	1987	The addition of 1,25(OH)2D3 at 10(-15) M or 10(-11) M augmented IL-2 production by MLA-144 cells in vitamin D-deficient rat serum, but not in fetal calf serum.	Vitamin D	100-109	interleukin 2	Mus musculus	64-68
3027219-5	1987	At 10(-7) M 1,25(OH)2D3 there was inhibition of IL-2 production by MLA-144 cells in either vitamin D-deficient serum or FCS.	Vitamin D	91-100	interleukin 2	Mus musculus	48-52
3829120-1	1987	The molecular cloning of a cDNA fragment synthesised from rat duodenal mRNA coding for cholecalcin (calbindin), a 9000 Mr vitamin D-induced calcium-binding protein (CaBP), has been previously described.	Vitamin D	122-131	S100 calcium binding protein G	Rattus norvegicus	87-98
3550213-1	1987	The kidney distribution of 28 kDa vitamin D-induced calcium binding protein (CaBP) was studied in 15 fetuses (11 to 33 weeks old), six children and adults (12 days to 32 years old) by immunocytochemistry using a specific antibody to rat renal 28 kDa CaBP.	Vitamin D	34-43	S100 calcium binding protein G	Rattus norvegicus	250-254
4053351-2	1985	Antibodies were generated in rabbits immunized with a new vitamin D analog, the 23,24,25,26,27-pentanor-C(22)-carboxylic acid of vitamin D, coupled directly with bovine serum albumin.	Vitamin D	58-67	albumin	Oryctolagus cuniculus	169-182
4053351-2	1985	Antibodies were generated in rabbits immunized with a new vitamin D analog, the 23,24,25,26,27-pentanor-C(22)-carboxylic acid of vitamin D, coupled directly with bovine serum albumin.	Vitamin D	129-138	albumin	Oryctolagus cuniculus	169-182
2995887-0	1985	Vitamin D hormone regulates myc-oncogene expression in tissue culture.	Vitamin D	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	28-31
4027624-2	1985	This is the same protein as the vitamin D-dependent kidney CaBP, but its Purkinje cell level is apparently vitamin D independent.	Vitamin D	32-41	S100 calcium binding protein G	Rattus norvegicus	59-63
2862038-8	1985	The rapid production of fully functional cholecalcin mRNA, which was detectable as early as 1 h after a single dose of calcitriol to vitamin-D-deficient rats, provides convincing evidence that calcitriol increases 9-kDa cholecalcin production by increasing cholecalcin gene expression at the transcriptional level.	Vitamin D	133-142	S100 calcium binding protein G	Rattus norvegicus	41-52
6430904-2	1984	A vitamin D-dependent Mr = 28,000 calcium-binding protein (CaBP) has been isolated from rat kidney.	Vitamin D	2-11	S100 calcium binding protein G	Rattus norvegicus	59-63
6204907-1	1984	A calcium binding protein (CaBP) with an apparent relative molecular weight of 28,000 was localized in the kidney of Anolis carolinensis with antisera directed against vitamin D-dependent CaBP from either rat kidney (RRCaBP) or chick intestine (CICaBP).	Vitamin D	168-177	S100 calcium binding protein G	Rattus norvegicus	27-31
6204907-1	1984	A calcium binding protein (CaBP) with an apparent relative molecular weight of 28,000 was localized in the kidney of Anolis carolinensis with antisera directed against vitamin D-dependent CaBP from either rat kidney (RRCaBP) or chick intestine (CICaBP).	Vitamin D	168-177	S100 calcium binding protein G	Rattus norvegicus	188-192
6546644-2	1984	Vitamin D deficiency abolished net calcium absorption [J net, -2 +/- 2 vs. 12 +/- 2 (SE) nmol X cm-2 X h-1, P less than 0.001], and 10 ng of 1,25(OH)2D3 raised J net to levels found in normal rats.	Vitamin D	0-9	solute carrier family 6 member 2	Rattus norvegicus	57-60
6278948-6	1982	Associated with this refractoriness to the hormone was a marked reduction in PTH receptors in membranes from both vitamin D-deficient and calcium-deficient chick kidney.	Vitamin D	114-123	parathyroid hormone	Gallus gallus	77-80
6163782-3	1981	The mouse protein had a molecular weight of approximately 10,000, exhibited cation-binding properties, and demonstrated immunologic identity with vitamin D-dependent rat CaBP.	Vitamin D	146-155	S100 calcium binding protein G	Rattus norvegicus	170-174
7366438-0	1980	Gas--liquid chromatography of vitamin D and analogs.	Vitamin D	30-39	gastrin	Homo sapiens	0-3
227925-7	1979	Relaxation of tension after tetanic stimulation was slowed in the vitamin D-deficient chicks (20.6 ms, SD 1.7, vs. 15.4, SD 1.3, in vitamin D-treated chicks and 15.3, SD 1.0, in normal control chicks), and in vitro (45)Ca(++) transport by sarcoplasmic reticulum from the vitamin D-deficient chicks was reduced.	Vitamin D	66-75	CUP2Q35	Homo sapiens	103-107
227925-7	1979	Relaxation of tension after tetanic stimulation was slowed in the vitamin D-deficient chicks (20.6 ms, SD 1.7, vs. 15.4, SD 1.3, in vitamin D-treated chicks and 15.3, SD 1.0, in normal control chicks), and in vitro (45)Ca(++) transport by sarcoplasmic reticulum from the vitamin D-deficient chicks was reduced.	Vitamin D	66-75	CUP2Q35	Homo sapiens	121-125
227925-7	1979	Relaxation of tension after tetanic stimulation was slowed in the vitamin D-deficient chicks (20.6 ms, SD 1.7, vs. 15.4, SD 1.3, in vitamin D-treated chicks and 15.3, SD 1.0, in normal control chicks), and in vitro (45)Ca(++) transport by sarcoplasmic reticulum from the vitamin D-deficient chicks was reduced.	Vitamin D	66-75	CUP2Q35	Homo sapiens	121-125
92374-1	1979	The binding properties towards vitamin D metabolites of plasma from individuals with the three common Gc-globulin phenotypes, Gc-1, Gc-2 and Gc-2-1, have been found to be identical.	Vitamin D	31-40	solute carrier family 25 member 22	Homo sapiens	126-136
1198113-1	1975	Treatment of duodenal tissue from rats deficient in vitamin D with 1,25-dihydroxy-vitamin D3 [1,25-(OH)2-D3] led to more than a doubling of calcium uptake by the isolated cells and the appearacne in those cells of previously undetectable calcium-binding protein (CaBP).	Vitamin D	52-61	S100 calcium binding protein G	Rattus norvegicus	263-267
33978363-3	2021	Vitamin D deficiency was also linked to an increase in serum hepcidin levels.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	61-69
33596463-0	2021	Altered expression of the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 under the context of prostate aging and pathologies.	Vitamin D	26-35	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	57-64
33596463-6	2021	Such intricate unbalance in regard to vitamin D metabolizing enzymes was strongly associated with reduced bioavailability of calcitriol in the senile prostate, which in addition to decreased expression of the vitamin D receptor, further limits the protective actions mediated by vitamin D signaling.	Vitamin D	38-47	vitamin D receptor	Rattus norvegicus	209-227
33981701-3	2021	The aim of this study was to investigate whether vitamin D modulates mitochondrial fatty acid oxidase via sirtuin 3 signaling to protect the myocardium.	Vitamin D	49-58	sirtuin 3	Mus musculus	106-115
33882819-3	2021	Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR).	Vitamin D	18-27	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	72-79
33882819-3	2021	Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR).	Vitamin D	18-27	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	90-96
33889003-9	2021	Calcitriol, the active form of vitamin D, could activate VDR and attenuate diabetic nephropathy including proteinuria and glomerular sclerosis.	Vitamin D	31-40	vitamin D receptor	Rattus norvegicus	57-60
34017509-11	2021	IL-4 decreased following serum vitamin D level elevation (Y = -3.3515X+122.04, R2 = 0.9984).	Vitamin D	31-40	interleukin 4	Mus musculus	0-4
34017509-13	2021	Vitamin D level was significantly negatively correlated with IL-4, suggesting that vitamin D was closely related to inflammation.	Vitamin D	0-9	interleukin 4	Mus musculus	61-65
33836827-10	2021	The remarkable increase in the level of SREBP1c was associated to the suppression of INSIG2 in treated preadipocytes with 10 nM vitamin D plus BPA.	Vitamin D	128-137	sterol regulatory element binding transcription factor 1	Homo sapiens	40-47
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	fatty acid binding protein 4	Homo sapiens	67-72
33106919-1	2021	The objective of this study was to investigate the protective effects of vitamin D (Vit D) on anxiety and depression-like behaviors induced by unpredictable chronic mild stress and brain tissue oxidative damage criteria and neuroinflammation in rats.	Vitamin D	73-82	vitrin	Rattus norvegicus	84-87
33712053-4	2021	RESULTS: Our results showed that vitamin D receptor (VDR), as a mediator of most actions of 1,25-dihydroxyvitamin D3, glucose trasporter-4 (GLUT4),and fatty acid binding protein-4 (FABP4) was expressed in vitamin D-treated hASCs.	Vitamin D	33-42	fatty acid binding protein 4	Homo sapiens	151-179
33712053-4	2021	RESULTS: Our results showed that vitamin D receptor (VDR), as a mediator of most actions of 1,25-dihydroxyvitamin D3, glucose trasporter-4 (GLUT4),and fatty acid binding protein-4 (FABP4) was expressed in vitamin D-treated hASCs.	Vitamin D	33-42	fatty acid binding protein 4	Homo sapiens	181-186
33791222-9	2021	Additionally, we also found that the expression of CYP24A1, the main enzyme determining the biological half-life of calcitriol, was significantly inhibited by miR-1278, according to data from clinical, RNA-seq and functional assays, which allowed miR-1278 to sensitize CRC cells to vitamin D.	Vitamin D	282-291	microRNA 1278	Homo sapiens	159-167
33791222-9	2021	Additionally, we also found that the expression of CYP24A1, the main enzyme determining the biological half-life of calcitriol, was significantly inhibited by miR-1278, according to data from clinical, RNA-seq and functional assays, which allowed miR-1278 to sensitize CRC cells to vitamin D.	Vitamin D	282-291	microRNA 1278	Homo sapiens	247-255
33791222-10	2021	In summary, our data demonstrated that miR-1278 may serve as a potential tumor suppressor gene and biomarker for determining sensitivity to oxaliplatin and vitamin D in CRC.	Vitamin D	156-165	microRNA 1278	Homo sapiens	39-47
33428175-10	2021	In conclusion, our data indicate that concurrent vitamin D supplementation and ART, compared with monotherapy, successfully improve cardiac function and alleviate myocardial fibrosis via downregulating TGF-beta1, Smad2/3 signaling, and also regulating collagen I and III expressions.	Vitamin D	49-58	SMAD family member 2	Rattus norvegicus	213-220
33504558-15	2021	TNF-alpha significantly and inversely associated with SBP in the presence of vitamin D insufficiency, fully adjusted model beta = -13.61 (95% CI -24.42 to -2.80); however, TNF-alpha was not associated with SBP in the absence of vitamin D insufficiency.	Vitamin D	77-86	coiled-coil alpha-helical rod protein 1	Homo sapiens	54-57
33626316-1	2021	Since the discovery of its role in vitamin D metabolism, significant progress has been made in the understanding of gene organisation, protein structure, catalytic function, and genetic polymorphism of cytochrome P450 2R1 (CYP2R1).	Vitamin D	35-44	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	202-221
33626316-1	2021	Since the discovery of its role in vitamin D metabolism, significant progress has been made in the understanding of gene organisation, protein structure, catalytic function, and genetic polymorphism of cytochrome P450 2R1 (CYP2R1).	Vitamin D	35-44	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	223-229
33626316-5	2021	In liver, CYP2R1 25-hydroxylates vitamin D and serves as an important determinant of 25(OH)D level in the tissue and in circulation.	Vitamin D	33-42	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	10-16
33626316-9	2021	The role of other CYP2R1 SNPs in vitamin D deficiency and their causal link to other traits however remain uncertain currently and more studies are warranted to help identify possible physiological mechanisms underlying those complex traits.	Vitamin D	33-42	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	18-24
33197802-12	2021	Low vitamin D levels were defined as a risk factor for post-stroke epilepsy.	Vitamin D	4-13	solute carrier family 35 member G1	Homo sapiens	55-59
32270535-0	2021	Maternal Vitamin D Deficiency Increases Intestinal Permeability and Programs Wnt/beta-Catenin Pathway in BALB/C Mice.	Vitamin D	9-18	wingless-type MMTV integration site family, member 3A	Mus musculus	77-80
32270535-6	2021	Maternal vitamin D deficiency also repressed the messenger RNA expression of wingless/integrated family member 3a (Wnt3a) and the protein expression of nuclear beta-catenin.	Vitamin D	9-18	wingless-type MMTV integration site family, member 3A	Mus musculus	115-120
32270535-8	2021	The activation of the Wnt/beta-catenin pathway protected against the impairment of intestinal permeability induced by maternal vitamin D deficiency.	Vitamin D	127-136	wingless-type MMTV integration site family, member 3A	Mus musculus	22-25
33159979-0	2021	Vitamin D Exerts Neuroprotection via SIRT1/Nrf-2/ NF-kB Signaling Pathways against D-Galactose-induced Memory Impairment in Adult Mice.	Vitamin D	0-9	sirtuin 1	Mus musculus	37-42
32858177-7	2020	In particular, both Vitamin D response element (VDRE, -758 to -743) and osteoblast-specific cis- acting element 2 (OSE2, -695 to -690) were essential for cAMP-mediated OPNp activity.	Vitamin D	20-29	secreted phosphoprotein 1	Homo sapiens	168-172
33316808-6	2021	There was a strong negative association between vitamin D and leukocyte count (tau = -0.173, p = 0.007) and C-reactive protein concentration (tau = -0.172, p = 0.007).	Vitamin D	48-57	microtubule associated protein tau	Homo sapiens	79-82
33276664-1	2020	BACKGROUND: No previous study has investigated the association between gamma glutamyltransferase (GGT) and vitamin D in patients with stable coronary artery disease (CAD).	Vitamin D	107-116	gamma-glutamyltransferase light chain family member 3	Homo sapiens	71-96
33276664-1	2020	BACKGROUND: No previous study has investigated the association between gamma glutamyltransferase (GGT) and vitamin D in patients with stable coronary artery disease (CAD).	Vitamin D	107-116	gamma-glutamyltransferase light chain family member 3	Homo sapiens	98-101
33276664-2	2020	We investigated the cross-sectional associations between vitamin D status as assessed by serum 25(OH)D and GGT.	Vitamin D	57-66	gamma-glutamyltransferase light chain family member 3	Homo sapiens	107-110
33276664-6	2020	RESULTS: GGT activity was the highest in vitamin D severely deficient patients and the lowest in vitamin D insufficient patients.	Vitamin D	41-50	gamma-glutamyltransferase light chain family member 3	Homo sapiens	9-12
33276664-6	2020	RESULTS: GGT activity was the highest in vitamin D severely deficient patients and the lowest in vitamin D insufficient patients.	Vitamin D	97-106	gamma-glutamyltransferase light chain family member 3	Homo sapiens	9-12
33276664-8	2020	The receiver operating characteristics curve identified the discrimination threshold of GGT of >19 U/L in predicting vitamin D deficiency.	Vitamin D	117-126	gamma-glutamyltransferase light chain family member 3	Homo sapiens	88-91
33213976-14	2021	CONCLUSIONS: The results of our study support the effect of vitamin D in reducing prostate volume and PSA levels, and in improving BPH symptoms.	Vitamin D	60-69	kallikrein related peptidase 3	Homo sapiens	102-105
33463118-4	2020	In this study, the impacts of calcitriol, the active form of vitamin D, on the methylation of the conserved non-coding sequence 2 (CNS2) region of the forkhead box P3 (Foxp3) gene promoter, were evaluated.	Vitamin D	61-70	forkhead box P3	Mus musculus	151-166
33463118-4	2020	In this study, the impacts of calcitriol, the active form of vitamin D, on the methylation of the conserved non-coding sequence 2 (CNS2) region of the forkhead box P3 (Foxp3) gene promoter, were evaluated.	Vitamin D	61-70	forkhead box P3	Mus musculus	168-173
33463118-8	2020	Vitamin D Intervention significantly (p<0.05) could increase the expression of Foxp3, IL-10, and TGF-beta1 gene in the CD4+ T cells of mice comparing with the control group.	Vitamin D	0-9	forkhead box P3	Mus musculus	79-84
33463118-9	2020	Meanwhile, methylation of the CNS2 region of Foxp3 promoter was significantly decreased in three of ten CpG sites in the vitamin D group compared to the control group.	Vitamin D	121-130	forkhead box P3	Mus musculus	45-50
33463118-10	2020	The results of this study showed that vitamin D can engage the methylation process to induce Foxp3 gene expression and probably Treg cytokines profile.	Vitamin D	38-47	forkhead box P3	Mus musculus	93-98
32755551-0	2020	Vitamin D inhibits Tissue Factor and CAMs expression in oxidized low-density lipoproteins-treated human endothelial cells by modulating NF-kappaB pathway.	Vitamin D	0-9	coagulation factor III, tissue factor	Homo sapiens	19-32
33145139-7	2020	Post the extensive research over PubMed, it was noted that vitamin D, through its effect on multiple pathways, especially Wnt/beta-catenin, apoptosis, and inflammation, hinders the progression of CRC carcinogenesis.	Vitamin D	59-68	catenin beta 1	Homo sapiens	126-138
33061877-2	2020	We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels.	Vitamin D	30-39	kallikrein related peptidase 3	Homo sapiens	71-96
33061877-2	2020	We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels.	Vitamin D	30-39	kallikrein related peptidase 3	Homo sapiens	98-101
33061877-5	2020	The independent effect of vitamin D levels and age on PSA levels was determined with logistic regression.	Vitamin D	26-35	kallikrein related peptidase 3	Homo sapiens	54-57
32967132-0	2020	Vitamin D Correction Down-Regulates Serum Amyloid P Component Levels in Vitamin D Deficient Arab Adults: A Single-Arm Trial.	Vitamin D	0-9	amyloid P component, serum	Homo sapiens	36-61
32967132-0	2020	Vitamin D Correction Down-Regulates Serum Amyloid P Component Levels in Vitamin D Deficient Arab Adults: A Single-Arm Trial.	Vitamin D	72-81	amyloid P component, serum	Homo sapiens	36-61
32938288-9	2020	CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients.	Vitamin D	143-152	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	80-86
32938288-9	2020	CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients.	Vitamin D	170-179	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	80-86
32585450-1	2020	The biological activity of vitamin D, which mediated by the vitamin D receptor, is widespread throughout the body.	Vitamin D	27-36	vitamin D receptor	Rattus norvegicus	60-78
32622071-7	2020	Overall, there was a significant increase in serum DLK1 and leptin and a decrease in VCAM, but no change in CRP, after 12 months of vitamin D supplementation.	Vitamin D	132-141	leptin	Homo sapiens	60-66
31810868-7	2020	RESULTS: It was also found that active VD increased the concentration of VD in serum and VDR in liver of NAFLD rats, and alleviated hepatic fibrosis.	Vitamin D	39-41	vitamin D receptor	Rattus norvegicus	89-92
31810868-10	2020	CONCLUSION: Collectively, the evidences from this study demonstrated that active VD could alleviate the development of NAFLD through blocking the p53-p21 signaling pathway, which provided a novel nutritional therapeutic insight for NAFLD.	Vitamin D	81-83	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	146-149
32379895-12	2020	Studies examining the effect of vitamin D treatment on serum IGF-1 and IGFBP-3 have not been in agreement since different populations, dosages, and intervention periods have been used.	Vitamin D	32-41	insulin like growth factor binding protein 3	Homo sapiens	71-78
32604067-9	2020	Additionally, the upregulation of VDR, calbindin-D28k, and calbindin-D9k suggested that the vitamin D signaling system was amplified by vitamin D and 17beta-estradiol.	Vitamin D	92-101	vitamin D receptor	Rattus norvegicus	34-37
32604067-9	2020	Additionally, the upregulation of VDR, calbindin-D28k, and calbindin-D9k suggested that the vitamin D signaling system was amplified by vitamin D and 17beta-estradiol.	Vitamin D	92-101	S100 calcium binding protein G	Rattus norvegicus	59-72
32604067-9	2020	Additionally, the upregulation of VDR, calbindin-D28k, and calbindin-D9k suggested that the vitamin D signaling system was amplified by vitamin D and 17beta-estradiol.	Vitamin D	136-145	vitamin D receptor	Rattus norvegicus	34-37
32604067-9	2020	Additionally, the upregulation of VDR, calbindin-D28k, and calbindin-D9k suggested that the vitamin D signaling system was amplified by vitamin D and 17beta-estradiol.	Vitamin D	136-145	S100 calcium binding protein G	Rattus norvegicus	59-72
33842001-9	2021	Conclusion: Vitamin D inhibited lung cancer tumor growth, migration, and proliferation by downregulating HRC.	Vitamin D	12-21	histidine rich calcium binding protein	Mus musculus	105-108
32867112-9	2020	RESULTS: Rs731236 (VDR gene) and rs7116978 (CYP2R1 gene) showed a significant association with vitamin D status.	Vitamin D	95-104	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	44-50
32430692-1	2020	Vitamin D-dependent rickets type 1B (VDDR1B) is an autosomal semidominant genetic disorder caused by a deficiency in CYP2R1, which encodes vitamin D 25-hydroxylase, an enzyme that plays a crucial role in the conversion of vitamin D to 25-dihydroxyvitamin D3.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	117-123
32430692-1	2020	Vitamin D-dependent rickets type 1B (VDDR1B) is an autosomal semidominant genetic disorder caused by a deficiency in CYP2R1, which encodes vitamin D 25-hydroxylase, an enzyme that plays a crucial role in the conversion of vitamin D to 25-dihydroxyvitamin D3.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	139-163
32430692-1	2020	Vitamin D-dependent rickets type 1B (VDDR1B) is an autosomal semidominant genetic disorder caused by a deficiency in CYP2R1, which encodes vitamin D 25-hydroxylase, an enzyme that plays a crucial role in the conversion of vitamin D to 25-dihydroxyvitamin D3.	Vitamin D	139-148	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	117-123
32654051-12	2020	In this review, we aimed to discuss the role of vitamin D as an anti-inflammatory agent in relation to the pro-inflammatory process of preeclampsia through the activation of the TLR4 pathway.	Vitamin D	48-57	toll like receptor 4	Homo sapiens	178-182
32712621-10	2020	Vitamin D could decrease ROS level, apoptotic neuron cells and DUOX1 expression, and increase VDR expression.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	94-97
32540991-0	2020	Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells.	Vitamin D	0-9	MER proto-oncogene, tyrosine kinase	Homo sapiens	20-25
32540991-2	2020	The major circulating metabolite of vitamin D (25-hydroxyvitamin D) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1 In multiple sclerosis lesions, the tyrosine kinase MerTK expressed by myeloid cells regulates phagocytosis of myelin debris and apoptotic cells that can accumulate and inhibit tissue repair and remyelination.	Vitamin D	36-45	MER proto-oncogene, tyrosine kinase	Homo sapiens	198-203
32834827-12	2020	The combination of variants in CYP2R1 and CYP24A1 (GAC, to rs10500804, rs12794714 and rs3886163, respectively) was negatively associated with vitamin D production (beta = - 1.24; 95% CI - 2.42 to - 0.06).	Vitamin D	142-151	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	31-37
33680012-0	2020	The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study.	Vitamin D	23-32	leptin	Homo sapiens	83-89
33680012-4	2020	We aim to evaluate the effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin, and leptin to adiponectin ratio (LAR) of type 2 diabetes mellitus patients.	Vitamin D	42-51	leptin	Homo sapiens	114-120
33680012-8	2020	The results of study indicate a significant decline in circulating leptin and adiponectin after vitamin D treatment, but it doesn"t cause a noteworthy change in LAR.	Vitamin D	96-105	leptin	Homo sapiens	67-73
32452516-12	2020	These data suggest that vitamin D suppresses expression of Ucps in brown adipocyte in a Vdr-dependent manner and the corepressor Hairless protein probably plays a role in the downregulation.	Vitamin D	24-33	vitamin D receptor	Rattus norvegicus	88-91
32554862-0	2020	Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/beta-catenin signaling.	Vitamin D	0-9	catenin beta 1	Homo sapiens	143-155
32481491-10	2020	Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) -0.53, 95% CI -0.91 to -0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003).	Vitamin D	243-252	anti-Mullerian hormone	Homo sapiens	6-9
32481491-11	2020	In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.	Vitamin D	95-104	anti-Mullerian hormone	Homo sapiens	109-112
32352398-2	2020	The aim of the current study was to evaluate the effects of high-dose vitamin D supplementation on heat shock protein 27 antibody (anti-Hsp27) titers in adolescent girls.	Vitamin D	70-79	heat shock protein family B (small) member 1	Homo sapiens	136-141
32352398-6	2020	Furthermore, serum anti-Hsp27 titers were significantly lower after the 9-week vitamin D administration period (0.22 [0.12-0.33] optical density [OD] vs. 0.19 [0.11-0.31] OD; p = 0.002).	Vitamin D	79-88	heat shock protein family B (small) member 1	Homo sapiens	24-29
32352398-9	2020	Conclusions High-dose vitamin D supplementation was found to reduce antibody titers to Hsp27.	Vitamin D	22-31	heat shock protein family B (small) member 1	Homo sapiens	87-92
32508805-13	2020	Important for cellular therapies requiring isolation of Tregs, the absolute number of beta7+CD4+CD25+FOXP3+Tregs was positively associated with 25(OH)vitamin D3 (R 2 = 0.0208, r = 0.184, p = 0.021) whereas the absolute numbers of CLA+CD4+CD25+FOXP3+Tregs in the periphery were not influenced by vitamin D status.	Vitamin D	150-159	immunoglobulin kappa variable 2D-24 (non-functional)	Homo sapiens	86-91
32236871-0	2020	Complications of Phosphate and Vitamin D Treatment in X-Linked Hypophosphataemia.	Vitamin D	31-40	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	54-80
32159363-8	2020	Among them, we found that inhibition of RPS6KA1 promoted vitamin D sensitivity in PC-3 cells.	Vitamin D	57-66	ribosomal protein S6 kinase A1	Homo sapiens	40-47
32159363-10	2020	Overall, our study reveals that inhibitory mechanism of 1,25-VD on DNMT3B, which may contribute to vitamin D resistance in PCa.	Vitamin D	99-108	DNA methyltransferase 3 beta	Homo sapiens	67-73
32083542-7	2020	Serum vitamin D concentration (25(OH)D3) showed a protective effect on CIMT (OR= 0.94; CI= 0.89-0.99; p= 0.025).	Vitamin D	6-15	CIMT	Homo sapiens	71-75
32115644-3	2020	OBJECTIVE: To examine the possibility that common coding variation in vitamin D metabolizing enzymes alters vitamin D homeostasis we determined the effect of 44 nonsynonymous polymorphisms in CYP2R1, the vitamin D 25-hydroxylase, on enzyme function.	Vitamin D	70-79	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	204-228
32115644-10	2020	CONCLUSIONS: CYP2R1 polymorphisms have important effects on vitamin D homeostasis, and the geographic variability of CYP2R1 alleles represents an adaptation to differential exposures to UVB irradiation from sunlight.	Vitamin D	60-69	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	13-19
32272973-10	2020	The vitamin D supplementation decreased post-exercise (TN max) and 1 h post-exercise troponin (p = 0.004, p = 0.03, respectively), 1 h post-exercise myoglobin concentration (p = 0.01) and TNF-alpha levels(p < 0.03).	Vitamin D	4-13	myoglobin	Homo sapiens	149-158
32230936-0	2020	Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2.	Vitamin D	0-9	colon cancer associated transcript 2	Homo sapiens	89-94
32230936-8	2020	Our results suggest a novel anti-cancer mechanism of vitamin D by targeting CCAT2 in ovarian cancer.	Vitamin D	53-62	colon cancer associated transcript 2	Homo sapiens	76-81
32235811-1	2020	Vitamin D is associated with cardiovascular health through activating the vitamin D receptor that targets genes related to cardiovascular disease (CVD).	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	74-92
31991094-5	2020	In vitro analysis showed that probes consisting of a protein ligand and TCC could label vitamin D receptor and peroxisome proliferator-activated receptor gamma.	Vitamin D	88-97	sideroflexin 1	Homo sapiens	72-75
32138242-3	2020	In Mcoln1-/- mice, we found that a high dose of vitamin D (Vit D; 500,000 IU/kg/day) resulted in increased AMC compared to their wild-type littermates, which was accompanied by significant downregulation of SM22-alpha and upregulation of RUNX2 and osteopontin in the arterial media, indicating a phenotypic switch to osteogenic.	Vitamin D	48-57	mucolipin 1	Mus musculus	3-9
32138242-3	2020	In Mcoln1-/- mice, we found that a high dose of vitamin D (Vit D; 500,000 IU/kg/day) resulted in increased AMC compared to their wild-type littermates, which was accompanied by significant downregulation of SM22-alpha and upregulation of RUNX2 and osteopontin in the arterial media, indicating a phenotypic switch to osteogenic.	Vitamin D	48-57	transgelin	Mus musculus	207-217
32138242-3	2020	In Mcoln1-/- mice, we found that a high dose of vitamin D (Vit D; 500,000 IU/kg/day) resulted in increased AMC compared to their wild-type littermates, which was accompanied by significant downregulation of SM22-alpha and upregulation of RUNX2 and osteopontin in the arterial media, indicating a phenotypic switch to osteogenic.	Vitamin D	48-57	runt related transcription factor 2	Mus musculus	238-243
30607004-0	2020	A bone to pick with vitamin D deficiency and erectile dysfunction.	Vitamin D	20-29	protein interacting with PRKCA 1	Homo sapiens	10-14
30531693-8	2020	CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.	Vitamin D	55-64	vitamin D receptor	Rattus norvegicus	132-135
30531693-8	2020	CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.	Vitamin D	55-64	solute carrier family 2 member 4	Rattus norvegicus	156-161
31838171-8	2020	This CRMP2-NR2B interaction could be disrupted by a TAT-CBD3 peptide or OA, leading to attenuated memory protection in vitamin D-treated 3xTg-AD mice.	Vitamin D	119-128	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	11-15
31924508-0	2020	Investigation of the effects of vitamin D treatment on the ovarian AMH receptors in a polycystic ovary syndrome experimental model: an ultrastructural and immunohistochemical study.	Vitamin D	32-41	anti-Mullerian hormone	Rattus norvegicus	67-70
32121236-0	2020	Inflammation (IL-1beta) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study .	Vitamin D	47-56	interleukin 1 alpha	Homo sapiens	14-22
32184917-8	2020	Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1.	Vitamin D	29-38	neutrophil cytosolic factor 1	Mus musculus	175-182
32133333-1	2020	X-linked hypophosphatemia (XLH) causes significant burden in pediatric patients in spite of maintained treatment with phosphate supplements and vitamin D derivatives.	Vitamin D	144-153	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	0-25
32133333-1	2020	X-linked hypophosphatemia (XLH) causes significant burden in pediatric patients in spite of maintained treatment with phosphate supplements and vitamin D derivatives.	Vitamin D	144-153	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	27-30
32015399-4	2020	Asah1fl/fl/SMCre mice were found to have more severe AMC in both aorta and coronary arteries compared to their littermates (Asah1fl/fl/SMwt and WT/WT mice) after receiving a high dose vitamin D.	Vitamin D	184-193	N-acylsphingosine amidohydrolase 1	Mus musculus	0-5
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	peroxiredoxin 1	Mus musculus	148-153
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	sterol regulatory element binding transcription factor 1	Mus musculus	242-249
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	transformation related protein 53, pseudogene	Mus musculus	251-254
32918222-4	2020	The hormone derived from vitamin D, calcitriol (1,25-dihydroxyvitamin D3) and other related compounds, working via the vitamin D receptor and at least in part through endoplasmic reticulum protein 57 (ERp57), reduce cyclobutane pyrimidine dimers and oxidative DNA damage in keratinocytes and other skin cell types after UV.	Vitamin D	25-34	protein disulfide isomerase associated 3	Mus musculus	167-199
32918222-4	2020	The hormone derived from vitamin D, calcitriol (1,25-dihydroxyvitamin D3) and other related compounds, working via the vitamin D receptor and at least in part through endoplasmic reticulum protein 57 (ERp57), reduce cyclobutane pyrimidine dimers and oxidative DNA damage in keratinocytes and other skin cell types after UV.	Vitamin D	25-34	protein disulfide isomerase associated 3	Mus musculus	201-206
32238143-7	2020	The immunmodulatory effects of the active metabolite of vitamin D (alpha-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-beta and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC.	Vitamin D	56-65	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	138-144
32405353-0	2020	Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats.	Vitamin D	10-19	cAMP responsive element binding protein 1	Rattus norvegicus	39-43
32405353-10	2020	Results: Administration of vitamin D (4300 IU/kg/week) in a T1DM animal model increased CREB phosphorylation in the hippocampus, but the serum and hippocampal BDNF levels and TrkB and BDNF gene expression did not change significantly.	Vitamin D	27-36	cAMP responsive element binding protein 1	Rattus norvegicus	88-92
32405353-11	2020	Conclusion: Vitamin D increased hippocampal CREB phosphorylation in a T1DM animal model.	Vitamin D	12-21	cAMP responsive element binding protein 1	Rattus norvegicus	44-48
31797544-0	2020	Vitamin D Deficiency Induces Insulin Resistance and Re-supplementation Attenuates Hepatic Glucose Output Via the PI3K-AKT-FOXO1 Mediated Pathway.	Vitamin D	0-9	forkhead box O1	Mus musculus	122-127
32289634-2	2020	The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation.	Vitamin D	100-109	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	136-143
31949415-12	2019	The increase of serum hepcidin levels may be inhibited by effective treatment of anemia with iron supplementation and erythropoietin, and the treatment of secondary hyperparathyroidism with phosphate binders and the active form of vitamin D, which decrease serum parathyroid hormone and fibroblast growth factor-23 levels, and control inflammation to some extent.	Vitamin D	231-240	hepcidin antimicrobial peptide	Homo sapiens	22-30
32042764-0	2019	Vitamin D alleviates acute graft-versus-host disease through promoting the generation of Foxp3+ T cells.	Vitamin D	0-9	forkhead box P3	Mus musculus	89-94
31775036-5	2019	The function of MLL1 in restricting induction of EPSCs is mediated partly by Gc, which regulates cellular response to vitamin D signaling.	Vitamin D	118-127	lysine methyltransferase 2A	Homo sapiens	16-20
31725784-5	2019	The mineral absorption pathway genes, HMOX1 and VDR are involved in iron metabolism and response to vitamin D, respectively.	Vitamin D	100-109	heme oxygenase 1	Homo sapiens	38-43
31198072-7	2019	When vitamin D and calcium levels were compared between periodontal disease with diabetes to that of non-diabetics, statistically significant difference were found between the two with p-value of .001 indicating decrease in levels of vitamin D and calcium with increase in RBS and HbA1c values.	Vitamin D	5-14	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	273-276
31173353-9	2019	CONCLUSIONS: Vitamin D might contribute in reducing diabetic cardiomyopathy not only by improving blood glucose and insulin levels but also via downregulating AGE and hexosamine pathways and decreasing NF-kB activity in heart tissue.	Vitamin D	13-22	nuclear factor kappa B subunit 1	Rattus norvegicus	202-207
31556901-4	2019	During the "vitamin D winter" (November-March) up to 60-90% of the population shows deficient/insufficient (<20-30 ng mL-1) levels of vitamin D and it is explained by the difficulty in obtaining the recommended UV vitamin D doses.	Vitamin D	134-143	L1 cell adhesion molecule	Mus musculus	118-122
31556901-4	2019	During the "vitamin D winter" (November-March) up to 60-90% of the population shows deficient/insufficient (<20-30 ng mL-1) levels of vitamin D and it is explained by the difficulty in obtaining the recommended UV vitamin D doses.	Vitamin D	134-143	L1 cell adhesion molecule	Mus musculus	118-122
31723461-1	2019	Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined.	Vitamin D	37-46	serpin family B member 3	Homo sapiens	81-84
31723461-8	2019	In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P &lt; 0.001).	Vitamin D	87-96	serpin family B member 3	Homo sapiens	7-10
31723461-10	2019	In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk.	Vitamin D	38-47	serpin family B member 3	Homo sapiens	99-102
32274395-9	2019	Results: Our study showed that the administration of vitamin D (4300 IU/kg/week) in a streptozotocin-diabetic rat model resulted in increased serum vitamin D levels, FNDC5 gene expression and muscle irisin levels.	Vitamin D	53-62	fibronectin type III domain containing 5	Rattus norvegicus	166-171
30484255-16	2019	Furthermore, increased serum level of klotho could be a novel mechanism for antiaging effects of resveratrol and vitamin D.	Vitamin D	113-122	Klotho	Rattus norvegicus	38-44
31260744-0	2019	Vitamin D deficiency during pregnancy affects the function of Th1/Th2 cells and methylation of IFN-gamma gene in offspring rats.	Vitamin D	0-9	interferon gamma	Rattus norvegicus	95-104
31260744-9	2019	In conclusion, maternal vitamin D deficiency affected the function of Th1/Th2 cells and methylation of IFN-gamma gene in offspring rats.	Vitamin D	24-33	interferon gamma	Rattus norvegicus	103-112
30821057-9	2019	In the adjusted model, individuals who had vitamin D levels >19 ng mL-1 showed a lower prevalence of cognitive decline (prevalence ratio = 0.59; 95% confidence interval = 0.39-0.87).	Vitamin D	43-52	L1 cell adhesion molecule	Mus musculus	67-71
30821057-11	2019	CONCLUSIONS: The present study showed that individuals aged >=80 years who had vitamin D levels of <=18 ng mL-1 had a higher prevalence of cognitive decline even after adjustment for potential confounders.	Vitamin D	79-88	L1 cell adhesion molecule	Mus musculus	107-111
30802957-7	2019	Effect of vitamin D on basal IL-1alpha expression in mice was determined by topical administration to the gingiva of wild-type mice, followed by qRT-PCR.	Vitamin D	10-19	interleukin 1 alpha	Mus musculus	29-38
31375839-10	2019	Although CTX levels declined by 26.4% +- 5.3% (P = 0.0002) in NWB individuals (as anticipated), vitamin D supplementation resulted in an unexpected 25.8% +- 8% increase (P = 0.01) in CTX in LWB individuals, suggesting osteoclast activation.	Vitamin D	96-105	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	183-186
31417552-0	2019	Vitamin D Regulates the Microbiota to Control the Numbers of RORgammat/FoxP3+ Regulatory T Cells in the Colon.	Vitamin D	0-9	forkhead box P3	Mus musculus	71-76
31417552-2	2019	In this study, the role of vitamin D in the regulation of microbe induced RORgammat/FoxP3+ T regulatory (reg) cells in the colon was determined.	Vitamin D	27-36	forkhead box P3	Mus musculus	84-89
31417552-3	2019	Vitamin D sufficient (D+) mice had significantly higher frequencies of FoxP3+ and RORgammat/FoxP3+ T reg cells in the colon compared to vitamin D deficient (D-) mice.	Vitamin D	0-9	forkhead box P3	Mus musculus	71-76
31417552-3	2019	Vitamin D sufficient (D+) mice had significantly higher frequencies of FoxP3+ and RORgammat/FoxP3+ T reg cells in the colon compared to vitamin D deficient (D-) mice.	Vitamin D	0-9	forkhead box P3	Mus musculus	92-97
31417552-8	2019	Early vitamin D status shapes the microbiota to optimize the population of colonic RORgammat/FoxP3+ T reg cells important for resistance to colitis.	Vitamin D	6-15	forkhead box P3	Mus musculus	93-98
31357732-3	2019	Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D.	Vitamin D	167-176	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	110-116
31357732-3	2019	Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D.	Vitamin D	219-228	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	110-116
31311491-0	2019	Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study.	Vitamin D	4-13	leptin	Homo sapiens	68-74
31311491-1	2019	BACKGROUND: This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis factor, high sensitive C-reactive protein) and adipokines (adiponectin, leptin).	Vitamin D	71-80	leptin	Homo sapiens	289-295
31311491-10	2019	Vitamin D level was positively correlated with age and male, but negatively correlated with serum leptin level.	Vitamin D	0-9	leptin	Homo sapiens	98-104
31311491-11	2019	CONCLUSION: Subjects with low vitamin D level had higher odds for MS, but higher levels of leptin, compared to those with high vitamin D levels.	Vitamin D	30-39	leptin	Homo sapiens	91-97
31331440-0	2019	Polymorphisms in CYP2R1 Gene Associated with Serum Vitamin D Levels and Status in a Chinese Rural Population.	Vitamin D	51-60	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	17-23
30937698-6	2019	Conversely, Vitamin D increases glial tumor synthesis of neutrophins NGF and NT-3, the low affinity neurotrophin receptor p75NTR, IL-6 and VEGF, which may enhance glioma growth.	Vitamin D	12-21	nerve growth factor receptor	Homo sapiens	87-128
31147591-2	2019	Several studies indicate that the bioactive vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits proliferation and promotes epithelial differentiation of colon carcinoma cells in part through antagonism of the Wnt/beta-catenin pathway.	Vitamin D	44-53	catenin beta 1	Homo sapiens	235-247
31083424-4	2019	In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF.	Vitamin D	104-113	anti-Mullerian hormone	Homo sapiens	96-99
31083424-8	2019	RESULTS: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/ml; with a statistically significant relationship in FF.	Vitamin D	99-108	anti-Mullerian hormone	Homo sapiens	69-72
31083424-10	2019	CONCLUSIONS: As an existing "change-point problem" was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment.	Vitamin D	116-125	anti-Mullerian hormone	Homo sapiens	130-133
30537097-1	2019	1alpha,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Rattus norvegicus	152-170
30537097-1	2019	1alpha,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Rattus norvegicus	172-175
30988721-13	2019	Vitamin D can effectively treat Crohn"s disease, which may improve the chemotaxis and differentiation of Th1 cells by inhibiting IL-17/IL-17R pathway, thereby improving immune function and reducing the severity of disease.	Vitamin D	0-9	interleukin 17A	Rattus norvegicus	129-134
30478987-0	2019	Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy.	Vitamin D	7-16	triggering receptor expressed on myeloid cells 1	Homo sapiens	70-76
30478987-2	2019	This study aimed to investigate whether active vitamin D (VD) suppresses macrophage transition to the M1 phenotype via inhibiting the high glucose-induced STAT-1 phosphorylation to reduce TREM-1 expression.	Vitamin D	47-56	triggering receptor expressed on myeloid cells 1	Homo sapiens	188-194
30795966-8	2019	Logistic regression analysis showed that hypertension (odds ratio [OR] = 5.348, 95% confidence intervals [CI] 1.184-23.350, P = .026), expression of platelet CD62p (OR = 1.095, 95% CI 1.052-1.201, P = .018) and vitamin D level (OR = .832, 95% CI .763-.934, P = .005) were associated with CR in ischemic stroke patients.	Vitamin D	211-220	selectin P	Homo sapiens	158-163
31068287-1	2019	OBJECTIVE: To investigate the effect of vitamin D on microRNA-21(miR-21) expression and migration and invasion of human placental trophoblast cells.	Vitamin D	40-49	microRNA 21	Homo sapiens	65-71
31068287-2	2019	METHODS: The changes in the expression of miR-21 were detected using RT-qPCR in HTR-8/SVneo cells following stimulation by vitamin D at different doses for 24, 48 and 72 h.HTR-8/SVneo cells transfected with miR-21 mimic or inhibitor with or without vitamin D treatment were examined for changes in cell migration and invasion abilities using Transwell assay, and Western blotting was used to detect protein expressions of E-cadherin, fibronectin, and MMP9.	Vitamin D	123-132	microRNA 21	Homo sapiens	42-48
31068287-2	2019	METHODS: The changes in the expression of miR-21 were detected using RT-qPCR in HTR-8/SVneo cells following stimulation by vitamin D at different doses for 24, 48 and 72 h.HTR-8/SVneo cells transfected with miR-21 mimic or inhibitor with or without vitamin D treatment were examined for changes in cell migration and invasion abilities using Transwell assay, and Western blotting was used to detect protein expressions of E-cadherin, fibronectin, and MMP9.	Vitamin D	249-258	microRNA 21	Homo sapiens	42-48
31068287-3	2019	RESULTS: Vitamin D obviously inhibited the expression of micoRNA-21 in HTR-8/SVneo cells in a concentration-and time-dependent manner.Transfection with the miR-21 mimic significantly inhibited the migration and invasion of HTR-8/SVneo cells, and this inhibitory effect was abolished by treatment with vitamin D; transfection with miR-21 inhibitor obviously promoted the migration and invasion of HTR-8/SVneo cells, and these effects were not significantly affected by vitamin D treatment.	Vitamin D	9-18	microRNA 21	Homo sapiens	156-162
31068287-3	2019	RESULTS: Vitamin D obviously inhibited the expression of micoRNA-21 in HTR-8/SVneo cells in a concentration-and time-dependent manner.Transfection with the miR-21 mimic significantly inhibited the migration and invasion of HTR-8/SVneo cells, and this inhibitory effect was abolished by treatment with vitamin D; transfection with miR-21 inhibitor obviously promoted the migration and invasion of HTR-8/SVneo cells, and these effects were not significantly affected by vitamin D treatment.	Vitamin D	9-18	microRNA 21	Homo sapiens	330-336
31068287-3	2019	RESULTS: Vitamin D obviously inhibited the expression of micoRNA-21 in HTR-8/SVneo cells in a concentration-and time-dependent manner.Transfection with the miR-21 mimic significantly inhibited the migration and invasion of HTR-8/SVneo cells, and this inhibitory effect was abolished by treatment with vitamin D; transfection with miR-21 inhibitor obviously promoted the migration and invasion of HTR-8/SVneo cells, and these effects were not significantly affected by vitamin D treatment.	Vitamin D	301-310	microRNA 21	Homo sapiens	156-162
31068287-3	2019	RESULTS: Vitamin D obviously inhibited the expression of micoRNA-21 in HTR-8/SVneo cells in a concentration-and time-dependent manner.Transfection with the miR-21 mimic significantly inhibited the migration and invasion of HTR-8/SVneo cells, and this inhibitory effect was abolished by treatment with vitamin D; transfection with miR-21 inhibitor obviously promoted the migration and invasion of HTR-8/SVneo cells, and these effects were not significantly affected by vitamin D treatment.	Vitamin D	468-477	microRNA 21	Homo sapiens	156-162
31068287-4	2019	CONCLUSIONS: Vitamin D may promote trophoblast cell migration and invasion to accelerate the development of preeclampsia by down-regulating the expression of miR-21.	Vitamin D	13-22	microRNA 21	Homo sapiens	158-164
30157994-0	2019	Therapeutic Efficacy of Vitamin D in Experimental c-MET-beta-Catenin-Driven Hepatocellular Cancer.	Vitamin D	24-33	met proto-oncogene	Mus musculus	50-55
31105857-7	2019	In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway.	Vitamin D	221-230	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	52-55
31105857-7	2019	In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway.	Vitamin D	221-230	conserved helix-loop-helix ubiquitous kinase	Mus musculus	60-80
31040902-0	2019	Are serum leptin levels predicted by lipoproteins, vitamin D and body composition?	Vitamin D	51-60	leptin	Homo sapiens	10-16
31040902-2	2019	The connection between body composition, Vitamin D and leptin in young adults is important to be studied as body composition may affect bone health and therefore the possibility of osteoporosis in later life.	Vitamin D	41-50	leptin	Homo sapiens	55-61
31040902-3	2019	Few studies have attempted to investigate the effect of body composition and leptin with vitamin D in adolescence.	Vitamin D	89-98	leptin	Homo sapiens	77-83
29752008-0	2019	A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation.	Vitamin D	94-103	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	25-70
29752008-5	2019	We aimed to explore the association between a potential vitamin D-related polymorphism (the rs10766197 polymorphism in the CYP2R1 gene) with the response to supplementation of vitamin D in 253 healthy Iranian girls.	Vitamin D	56-65	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	123-129
29752008-5	2019	We aimed to explore the association between a potential vitamin D-related polymorphism (the rs10766197 polymorphism in the CYP2R1 gene) with the response to supplementation of vitamin D in 253 healthy Iranian girls.	Vitamin D	176-185	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	123-129
29752008-14	2019	CONCLUSION: Changes in serum vitamin D and metabolic profile following high dose supplementation with vitamin D were associated with CYP2R1 polymorphism.	Vitamin D	29-38	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	133-139
29752008-14	2019	CONCLUSION: Changes in serum vitamin D and metabolic profile following high dose supplementation with vitamin D were associated with CYP2R1 polymorphism.	Vitamin D	102-111	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	133-139
30639520-12	2019	These data suggest a key role of vitamin D in the control of inflammatory cytokine responses during DENV infection of human macrophages via the TLR4/NF-kappaB/miR-155-5p/SOCS-1 axis.	Vitamin D	33-42	toll like receptor 4	Homo sapiens	144-148
30639520-12	2019	These data suggest a key role of vitamin D in the control of inflammatory cytokine responses during DENV infection of human macrophages via the TLR4/NF-kappaB/miR-155-5p/SOCS-1 axis.	Vitamin D	33-42	suppressor of cytokine signaling 1	Homo sapiens	170-176
30922377-13	2019	CONCLUSIONS: Both analogs of vitamin D revealed their anti-inflammatory effect and reduced the level of Il-17A and Il-23 in the airway of CF patients with chronic P. aeruginosa infection.	Vitamin D	29-38	interleukin 23 subunit alpha	Homo sapiens	115-120
30893279-9	2021	The significant increase in HSP27 concentration was only noticed in SG with normal vitamin D concentrations.	Vitamin D	83-92	heat shock protein family B (small) member 1	Homo sapiens	28-33
30874583-4	2019	In contrast to cultivation in conventional tissue culture settings, on-chip cultivation of HepG2 and RPTEC cells in interconnected chambers, used to mimic the liver and kidneys, respectively, resulted in the enhanced expression of vitamin D metabolizing enzymes (CYP2R1, CYP27B1 and CYP24A1).	Vitamin D	231-240	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	263-269
29895850-9	2019	Deficient maternal vitamin D was also associated with lower ponderal index (beta -2.3 kg/m3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile.	Vitamin D	19-28	immunoglobulin kappa variable 2-24	Homo sapiens	76-85
30881343-7	2019	The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency.	Vitamin D	122-131	leptin	Homo sapiens	52-58
30881343-7	2019	The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency.	Vitamin D	122-131	resistin	Homo sapiens	73-81
30881343-7	2019	The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency.	Vitamin D	147-156	leptin	Homo sapiens	52-58
30881343-7	2019	The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency.	Vitamin D	147-156	resistin	Homo sapiens	73-81
30616171-0	2019	Vitamin D alleviates airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	0-9	Wnt family member 2	Rattus norvegicus	84-87
30616171-0	2019	Vitamin D alleviates airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	0-9	catenin beta 1	Rattus norvegicus	88-100
30616171-3	2019	The treatment with 100 ng/mL vitamin D remarkably reduced the thickness of the airway smooth muscle, collagen deposition, and the alpha-smooth muscle actin (alpha-SMA) mass and airway inflammation.	Vitamin D	29-38	actin gamma 2, smooth muscle	Rattus norvegicus	130-155
30669280-0	2019	The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.	Vitamin D	14-23	hepcidin antimicrobial peptide	Homo sapiens	43-51
31210105-6	2019	In addition, vitamin D supplementation down regulated low density lipoprotein receptor (LDLR) (P=0.03) expression in the subjects with diabetic HD than the control group.	Vitamin D	13-22	low density lipoprotein receptor	Homo sapiens	54-86
31210105-6	2019	In addition, vitamin D supplementation down regulated low density lipoprotein receptor (LDLR) (P=0.03) expression in the subjects with diabetic HD than the control group.	Vitamin D	13-22	low density lipoprotein receptor	Homo sapiens	88-92
31425951-0	2019	Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: A randomized, placebo-controlled, double-blind clinical trial.	Vitamin D	11-20	C-C motif chemokine ligand 2	Homo sapiens	63-68
31425951-5	2019	Therefore, this study was designed to investigate effects of vitamin D supplementation on serum levels of YKL-40 and MCP-1 involved in the development of diabetic complications.	Vitamin D	61-70	C-C motif chemokine ligand 2	Homo sapiens	117-122
31425951-12	2019	CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency.	Vitamin D	19-28	C-C motif chemokine ligand 2	Homo sapiens	88-93
31425951-12	2019	CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency.	Vitamin D	138-147	C-C motif chemokine ligand 2	Homo sapiens	88-93
31425951-13	2019	Vitamin D might contribute in reducing diabetic complications via modulating YKL-40 and MCP-1 signaling pathways.	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	88-93
31666475-0	2019	Poor Vitamin D Status in Active Pulmonary Tuberculosis Patients and Its Correlation with Leptin and TNF-alpha.	Vitamin D	5-14	leptin	Homo sapiens	89-95
30358420-7	2019	By increasing the level of cell cycle inhibitory and promoting proteins p21 and CDK1, vitamin D theoretically has both preventive and promoting effects on pancreatic cell division.	Vitamin D	86-95	cyclin dependent kinase 1	Homo sapiens	80-84
30395535-0	2018	Vitamin D stimulates multiple microRNAs to inhibit CRH and other pro-labor genes in human placenta.	Vitamin D	0-9	corticotropin releasing hormone	Homo sapiens	51-54
30395535-3	2018	In this study we test the hypothesis that vitamin D could contribute to the prevention of preterm labor by inhibiting CRH and other pro-labor mediators.	Vitamin D	42-51	corticotropin releasing hormone	Homo sapiens	118-121
30019416-1	2018	OBJECTIVE: This study aimed at investigating the association of serum vitamin D (25(OH)D) and anti-Mullerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS) as well as non-PCOS healthy ovulatory women and the possible confounding effects of adiposity and androgen.	Vitamin D	70-79	anti-Mullerian hormone	Homo sapiens	118-121
29855033-12	2018	Vitamin D restriction increases inflammation and reduces the expression of IGF-1 in the liver, worsening the fat-induced changing.	Vitamin D	0-9	insulin-like growth factor 1	Rattus norvegicus	75-80
29654274-8	2018	These data suggest that vitamin D holds a key role for the effector functions of MAMs and that vitamin D supplementation in IMiD combination trials could further increase the therapeutic efficacy of anti-CD38 antibodies such as MOR202, which remains to be investigated in clinical studies.	Vitamin D	95-104	CD38 molecule	Homo sapiens	204-208
30298486-1	2018	OBJECTIVE: To explore the molecular basis for three pedigrees affected with hypophosphatemia vitamin D resistant rickets (X-linked hypophosphatemia, XLH).	Vitamin D	93-102	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	149-152
30286768-3	2018	Therefore, this study was conducted to determine the effects of vitamin D supplementation on the levels of anti-Mullerian hormone (AMH), metabolic profiles, and gene expression of insulin and lipid metabolism in infertile women with PCOS who were candidate for in vitro fertilization (IVF).	Vitamin D	64-73	anti-Mullerian hormone	Homo sapiens	131-134
30157189-7	2018	Vitamin D also differentially affected PM-stimulated GM-CSF, with suppression in healthy HBECs and enhancement in asthmatic cultures.	Vitamin D	0-9	colony stimulating factor 2	Homo sapiens	53-59
30186876-7	2018	These findings suggested that RBP4 could involve in the improvement of diabetic atherosclerosis; vitamin D had the ability to decrease the level of RBP4 and eventually played an important role in preventing atherosclerosis in diabetes.	Vitamin D	97-106	retinol binding protein 4	Rattus norvegicus	148-152
29808911-11	2018	Having a previous SCC appeared associated with not being vitamin D deficient (OR = 0.46, 95%CI = 0.20-1.11, P = 0.084).	Vitamin D	57-66	serpin family B member 3	Homo sapiens	18-21
29759135-3	2018	It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively.	Vitamin D	233-242	CD83 molecule	Homo sapiens	112-116
29281615-2	2018	As an established regulator of TLR4, vitamin D has been demonstrated to be intestinal-protective.	Vitamin D	37-46	toll like receptor 4	Homo sapiens	31-35
29281615-9	2018	The vitamin D/VDR pathway protects against intestinal injury of NEC partly through suppressing the expression of TLR4.	Vitamin D	4-13	toll like receptor 4	Homo sapiens	113-117
29508414-0	2018	Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging-related prostate lesions.	Vitamin D	8-17	vitamin D receptor	Rattus norvegicus	28-31
29508414-7	2018	Interestingly, RXR expression in the aging prostate was similar to that found for its partner VDR, indicating that components of the VDR/RXR complex required for vitamin D signaling are affected in aging-related prostatic lesions.	Vitamin D	162-171	vitamin D receptor	Rattus norvegicus	133-136
29719821-7	2018	SLC37A1 seems to be required for lipid biosynthesis in cancer cell lines, SLC37A2 has been proposed as a vitamin D and a phospho-progesterone receptor target gene, while mutations in the SLC37A3 gene appear to be associated with congenital hyperinsulinism of infancy.	Vitamin D	105-114	solute carrier family 37 member 1	Homo sapiens	0-7
29524502-11	2018	PAI-1 induction may also be related to a function of monocytes/macrophages in response to xenobiotic and vitamin D signaling.	Vitamin D	105-114	serpin family E member 1	Homo sapiens	0-5
29628342-0	2018	MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin.	Vitamin D	18-27	maternally expressed 3	Homo sapiens	0-4
29628342-7	2018	These results suggested that MEG3 functions as a tumor suppressor in CRC via regulating the Clusterin activities and may underlie the anticancer activities of vitamin D on CRC cells.	Vitamin D	159-168	maternally expressed 3	Homo sapiens	29-33
29105518-1	2018	The relationship between serum anti-Mullerian hormone (AMH) with vitamin D (25OH-D) and metabolic syndrome (MetS) risk was evaluated in healthy, late reproductive-age (35-49 years) women with regular menstrual cycles.	Vitamin D	65-74	anti-Mullerian hormone	Homo sapiens	55-58
29642181-9	2018	Furthermore, based on the OR values, association of vitamin D insufficiency with disease type, study location, number of patients, and methods for detecting CLA was observed.	Vitamin D	52-61	selectin P ligand	Homo sapiens	157-160
28765037-0	2018	Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility.	Vitamin D	0-9	C-C motif chemokine ligand 2	Homo sapiens	32-37
28765037-8	2018	We found a downregulation of CCL-2 after vitamin D treatment in IL1beta-stimulated monocytes both from AD patients and HC (AD p&lt;0.001; HC p&lt;0.0001).	Vitamin D	41-50	C-C motif chemokine ligand 2	Homo sapiens	29-34
29552033-2	2018	We investigated the role of vitamin D in the regulation of 25OHD-1alpha-hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats.	Vitamin D	28-37	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	59-83
29552033-2	2018	We investigated the role of vitamin D in the regulation of 25OHD-1alpha-hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats.	Vitamin D	28-37	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	85-92
29552033-2	2018	We investigated the role of vitamin D in the regulation of 25OHD-1alpha-hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats.	Vitamin D	28-37	vitamin D receptor	Rattus norvegicus	98-101
29552033-8	2018	Vitamin D deficiency was accompanied by elevated synthesis of renal CYP27B1 and VDR.	Vitamin D	0-9	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	68-75
29552033-8	2018	Vitamin D deficiency was accompanied by elevated synthesis of renal CYP27B1 and VDR.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	80-83
29552033-11	2018	Conclusions: T1D-induced vitamin D deficiency is associated with impairments of renal and extrarenal CYP27B1 and VDR expression.	Vitamin D	25-34	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	101-108
29552033-11	2018	Conclusions: T1D-induced vitamin D deficiency is associated with impairments of renal and extrarenal CYP27B1 and VDR expression.	Vitamin D	25-34	vitamin D receptor	Rattus norvegicus	113-116
29243851-0	2018	Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.	Vitamin D	34-43	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	98-102
29243851-1	2018	The vitamin D-deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D-deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and liver cholesterol, and a reduction in cholesterol 7alpha-hydroxylase (Cyp7a1, rate-limiting enzyme for cholesterol metabolism) and renal Oat3 mRNA/protein expression levels.	Vitamin D	4-13	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	390-394
29321080-8	2018	Low prenatal vitamin D levels were associated with lower birth weight (g) (MD -100 69; 95 % CI -162 25, -39 13), increased risk of small-for-gestational-age (OR 1 55; 95 % CI 1 16, 2 07) and an elevated weight (g) in infant at the age of 9 months (g) (MD 119 75; 95 % CI 32 97, 206 52).	Vitamin D	13-22	olfactory receptor family 2 subfamily M member 4	Homo sapiens	158-165
29018141-0	2018	Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.	Vitamin D	0-9	ret proto-oncogene	Homo sapiens	29-32
29018141-5	2018	The absence of vitamin D ligand in gestation reduces C-Ret expression, but not GDNF and GFRalpha1, in embryo forebrains.	Vitamin D	15-24	ret proto-oncogene	Homo sapiens	53-58
29351340-7	2018	HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice.	Vitamin D	8-17	F-box protein 32	Mus musculus	92-101
29354129-0	2017	Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-gamma Production.	Vitamin D	0-9	interferon gamma	Rattus norvegicus	112-128
29962435-0	2018	Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells.	Vitamin D	0-9	forkhead box O1	Mus musculus	21-26
29962435-4	2018	In this study, we found that vitamin D inhibited FOXO1-mediated transcriptional activity in a reporter gene assay.	Vitamin D	29-38	forkhead box O1	Mus musculus	49-54
29962435-5	2018	Moreover, vitamin D suppressed the glucocorticoid-induced gene expression of atrogin 1 and cathepsin L in C2C12 myoblasts.	Vitamin D	10-19	F-box protein 32	Mus musculus	77-86
29962435-5	2018	Moreover, vitamin D suppressed the glucocorticoid-induced gene expression of atrogin 1 and cathepsin L in C2C12 myoblasts.	Vitamin D	10-19	cathepsin L	Mus musculus	91-102
29962435-6	2018	Thus, vitamin D may prevent muscle atrophy via the FOXO1-mediated pathway in muscle cells.	Vitamin D	6-15	forkhead box O1	Mus musculus	51-56
28161533-6	2018	Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays.	Vitamin D	70-79	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	127-134
29505145-2	2018	We examined the effect of high-dose vitamin D therapy on hemoglobin and hepcidin concentrations in critically ill adults.	Vitamin D	36-45	hepcidin antimicrobial peptide	Homo sapiens	72-80
30362842-9	2018	At 15 ng/mL cut-off value, vitamin D was negatively correlated with MCP-1 (p = .0006).	Vitamin D	27-36	C-C motif chemokine ligand 2	Homo sapiens	68-73
30362842-11	2018	MCP-1 was a risk factor for vitamin D deficiency (p &lt; .0001).	Vitamin D	28-37	C-C motif chemokine ligand 2	Homo sapiens	0-5
29295491-12	2017	The results of the study support the existence of the relationship among vitamin D, obesity and leptin in type 2 diabetic patients.	Vitamin D	73-82	leptin	Homo sapiens	96-102
29061851-0	2017	Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice.	Vitamin D	9-18	CD274 molecule	Homo sapiens	48-53
29061851-6	2017	We identified and characterized vitamin D response elements (VDREs) located in both genes and showed that 1,25D treatment induces cell-surface expression of PD-L1 in epithelial and myeloid cells.	Vitamin D	32-41	CD274 molecule	Homo sapiens	157-162
28374624-0	2017	Elevated serum leptin levels are associated with low vitamin D, sarcopenic obesity, poor muscle strength, and physical performance in knee osteoarthritis.	Vitamin D	53-62	leptin	Homo sapiens	15-21
28707894-3	2017	The present study primarily focused on the creation of a condition that prevents the genomic or nongenomic action of vitamin D by disrupting vitamin D receptors (VDR or PDIA3/1,25MARRS); the effects of these disruptions on the series of proteins involved in secretases that play a crucial role in amyloid pathology and on amyloid beta (Abeta) production in primary cortical neurons were observed.	Vitamin D	117-126	vitamin D receptor	Rattus norvegicus	162-165
27966571-1	2017	We aimed to investigate the potential association between vitamin D and serum leptin levels by pooling together the results from observational studies and clinical trials.	Vitamin D	58-67	leptin	Homo sapiens	78-84
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	notch receptor 3	Homo sapiens	91-97
27923595-10	2017	The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance.	Vitamin D	4-13	jagged canonical Notch ligand 1	Homo sapiens	99-103
27923595-11	2017	In addition, the vitamin D compounds up-regulated myoepithelial differentiating markers, cytokeratin 14 and smooth muscle actin, and down-regulated the luminal marker, cytokeratin 18.	Vitamin D	17-26	keratin 14	Homo sapiens	89-103
27923595-11	2017	In addition, the vitamin D compounds up-regulated myoepithelial differentiating markers, cytokeratin 14 and smooth muscle actin, and down-regulated the luminal marker, cytokeratin 18.	Vitamin D	17-26	keratin 18	Homo sapiens	168-182
27923595-12	2017	Cytokeratin 5, a biomarker associated with basal-like breast cancer, was found to be significantly down-regulated by the vitamin D compounds.	Vitamin D	121-130	keratin 5	Homo sapiens	0-13
28463086-0	2017	Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-gamma+ Response Driven by Urban Particulate Matter.	Vitamin D	0-9	interleukin 23 subunit alpha	Homo sapiens	25-30
28862504-0	2017	Breaking Steroid Resistance: Effect of Vitamin D on IL-23.	Vitamin D	39-48	interleukin 23 subunit alpha	Homo sapiens	52-57
28229278-9	2017	CONCLUSIONS: Daily intake of vitamin D-fortified doogh may increase circulating leptin and ghrelin but L/G ratio may actually decrease.	Vitamin D	29-38	leptin	Homo sapiens	80-86
28700535-0	2017	Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease.	Vitamin D	0-9	hepcidin antimicrobial peptide	Homo sapiens	36-44
28700535-2	2017	Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines.	Vitamin D	120-129	hepcidin antimicrobial peptide	Homo sapiens	191-199
28757204-0	2017	Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.	Vitamin D	73-82	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	45-51
28757204-8	2017	In conclusion, we describe a low-frequency CYP2R1 coding variant that exerts the largest effect upon 25OHD levels identified to date in the general European population and implicates vitamin D in the etiology of multiple sclerosis.	Vitamin D	183-192	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	43-49
28801380-5	2017	Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively.	Vitamin D	11-20	interleukin 1 alpha	Homo sapiens	113-117
27927883-1	2017	Objectives The aim of this study was to assess the vitamin D status in treatment-naive SLE patients and its association with clinical and laboratory markers of disease activity, including serum levels of IL-17 and IL-23.	Vitamin D	51-60	interleukin 23 subunit alpha	Homo sapiens	214-219
28958142-8	2017	Low 25(OH) vitamin D levels correlated with the presence of ACS (p&lt; 0.02) and inversely correlated with Troponin T hs (TnT hs) levels (p&lt; 0.03).	Vitamin D	11-20	troponin T1, slow skeletal type	Homo sapiens	122-125
28384529-0	2017	Vitamin D reduces the inflammatory response by Porphyromonas gingivalis infection by modulating human beta-defensin-3 in human gingival epithelium and periodontal ligament cells.	Vitamin D	0-9	defensin beta 103B	Homo sapiens	102-117
28384529-8	2017	Our results indicate that vitamin D specifically enhances the production of the human-beta-defensin 3 antimicrobial peptide and exerts an inhibitory effect on the pro-inflammatory cytokines, thus suggesting that vitamin D may offer possible therapeutic applications for periodontitis.	Vitamin D	26-35	defensin beta 103B	Homo sapiens	86-101
28384529-8	2017	Our results indicate that vitamin D specifically enhances the production of the human-beta-defensin 3 antimicrobial peptide and exerts an inhibitory effect on the pro-inflammatory cytokines, thus suggesting that vitamin D may offer possible therapeutic applications for periodontitis.	Vitamin D	212-221	defensin beta 103B	Homo sapiens	86-101
27987058-5	2017	Vitamin D significantly attenuated the MPTP-induced loss of tyrosine hydrlase (TH)-positive neuronal cells, microglial cell activation (Iba1-immunoreactive), inducible nitric oxide synthase (iNOS) and TLR-4 expression, typical hallmarks of the pro-inflammatory (M1) activation of microglia.	Vitamin D	0-9	induction of brown adipocytes 1	Mus musculus	136-140
28377587-5	2017	Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line).	Vitamin D	49-58	vitamin D receptor	Rattus norvegicus	90-108
28377587-5	2017	Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line).	Vitamin D	49-58	vitamin D receptor	Rattus norvegicus	110-113
28377587-5	2017	Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line).	Vitamin D	49-58	vitamin D receptor	Rattus norvegicus	186-189
27524803-6	2017	Severe vitamin D deficiency (serum 25-OH-D concentration &lt;10 ng mL-1 ) affected 35% of this population.	Vitamin D	7-16	L1 cell adhesion molecule	Mus musculus	67-71
28423519-3	2017	Both circulating vitamin D and muscle VDR expression increased after vitamin D administration, without exerting appreciable effects on body weight and muscle mass.The effects of vitamin D on muscle cells were studied in C2C12 myocytes.	Vitamin D	69-78	vitamin D receptor	Rattus norvegicus	38-41
28423519-3	2017	Both circulating vitamin D and muscle VDR expression increased after vitamin D administration, without exerting appreciable effects on body weight and muscle mass.The effects of vitamin D on muscle cells were studied in C2C12 myocytes.	Vitamin D	69-78	vitamin D receptor	Rattus norvegicus	38-41
28423519-5	2017	Vitamin D treatment resulted in VDR overexpression and myogenin down-regulation.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	32-35
28423519-6	2017	Silencing VDR expression in C2C12 cultures abrogated the inhibition of differentiation exerted by vitamin D treatment.These data suggest that VDR overexpression in tumor-bearing animals contributes to muscle wasting by impairing muscle regenerative program.	Vitamin D	98-107	vitamin D receptor	Rattus norvegicus	10-13
28423519-6	2017	Silencing VDR expression in C2C12 cultures abrogated the inhibition of differentiation exerted by vitamin D treatment.These data suggest that VDR overexpression in tumor-bearing animals contributes to muscle wasting by impairing muscle regenerative program.	Vitamin D	98-107	vitamin D receptor	Rattus norvegicus	142-145
28303937-0	2017	Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.	Vitamin D	0-9	vitamin D receptor	Rattus norvegicus	45-48
27927849-19	2017	LIMITATIONS, REASONS FOR CAUTION: Although this is the first prospective study to evaluate the relationship between vitamin D and the most important ovarian reserve markers (AMH and AFC), we need to acknowledge that the data used to generate the study findings are cross-sectional in nature.	Vitamin D	116-125	anti-Mullerian hormone	Homo sapiens	174-177
27224553-3	2017	METHODS: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEF &lt;45%) from the Vitamin D CHF (VitD-CHF) study (NCT01092130) were compared with those in age- and sex-matched healthy control subjects (n = 58) from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study.	Vitamin D	136-145	WAP four-disulfide core domain 2	Homo sapiens	15-18
27862673-7	2017	The vitamin D treatment group had significantly increased VEGF, and reduced sFlt-1 and TNF-alpha compared with the untreated PE group.	Vitamin D	4-13	vascular endothelial growth factor A	Rattus norvegicus	58-62
27473187-0	2017	CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.	Vitamin D	71-80	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
27473187-12	2017	CONCLUSION: This study showed a difference in 25(OH)D levels between CYP2R1 genotypes that equates a daily supplementation of 400-800 IU vitamin D, depending on genotype.	Vitamin D	137-146	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	69-75
27933507-8	2017	Severe vitamin D deficiency, i.e. &lt;25 nmol/l 25(OH)D was present in 23.6% of women overall.	Vitamin D	7-16	immunoglobulin kappa variable 3D-7	Homo sapiens	46-55
27727459-8	2016	In agreement with the proteomics findings, ELISA measurements showed vitamin K-dependent protein C, von Willebrand factor, fibrinogen gamma chain and multimerin-1 proteins, of relevance to blood coagulation, to be differentially affected (P-value &lt;= 0 05) between sexes after vitamin D status correction.	Vitamin D	279-288	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	69-162
27097322-6	2016	Athletes who had lower vitamin D status had reduced performance scores (p &lt; .01) with odds ratios of 0.85 on the Vertical Jump Test, 0.82 on the Shuttle Run Test, 0.28 on the Triple Hop for Distance Test, and 0.23 on the 1 RM Squat Test.	Vitamin D	23-32	HOP homeobox	Homo sapiens	185-188
27357175-9	2016	In confounder-adjusted analyses (age, height, lean mass, fat mass, menopause, smoking, estrogen replacement, calcium/vitamin D supplementation, and education) TB and hip BMD were both positively associated with cIMT (0.071 [0.030, 0.112], p = 0.001; 0.063 [0.025, 0.101], p = 0.001, respectively).	Vitamin D	117-126	CIMT	Homo sapiens	211-215
27237933-12	2016	A total of 176 (86%) of the study population was deficient in vitamin D, according to a level &lt;30 ng mL-1 .	Vitamin D	62-71	L1 cell adhesion molecule	Mus musculus	104-108
27504197-10	2016	In diabetic groups; serum vitamin D was found to be correlated negatively with serum glucose, insulin, HOMA, cholesterol, triglycerides, and LDL and positively correlated with HDL and tissue VDR.	Vitamin D	26-35	vitamin D receptor	Rattus norvegicus	191-194
27430408-8	2016	Furthermore, vitamin D increased the mRNA expression levels of LC3 and Beclin 1, and increased Bcl-2 protein expression levels in STZ-treated MIN6 cells, while decreasing the apoptosis rate.	Vitamin D	13-22	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	63-66
27430408-8	2016	Furthermore, vitamin D increased the mRNA expression levels of LC3 and Beclin 1, and increased Bcl-2 protein expression levels in STZ-treated MIN6 cells, while decreasing the apoptosis rate.	Vitamin D	13-22	beclin 1, autophagy related	Mus musculus	71-79
27557122-2	2016	However, epidemiologic studies on orally taken vitamin D and risk of skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], and melanoma) are few.	Vitamin D	47-56	serpin family B member 3	Homo sapiens	135-138
26991691-3	2016	OBJECTIVE: We examined whether serum vitamin D concentration was associated with sex steroid hormone and PSA concentrations in a cross-sectional analysis of men in the National Health and Nutrition Examination Surveys (NHANES).	Vitamin D	37-46	kallikrein related peptidase 3	Homo sapiens	105-108
27441845-0	2016	Correction: Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency.	Vitamin D	73-82	serpin family C member 1	Homo sapiens	54-62
27088321-7	2016	An intergenic polymorphism between CSPG5 and ELP6 was genome-wide significant, whereas several others exhibited suggestive associations (P &lt; 5.0 x 10), including genes encoding protein tyrosine phosphatases (PTPRM and PTPRN2) and the vitamin D metabolism gene, CYP24A1.	Vitamin D	237-246	protein tyrosine phosphatase receptor type M	Homo sapiens	211-216
27198036-5	2016	Vitamin D, K and Ca co-supplementation resulted in a significant reduction in maximum levels of left CIMT (-0 04 (sd 0 22) v. +0 04 (sd 0 09) mm, P=0 02).	Vitamin D	0-9	CIMT	Homo sapiens	101-105
27198036-8	2016	Overall, vitamin D, K and Ca co-supplementation for 12 weeks among diabetic patients with CHD had beneficial effects on maximum levels of left CIMT and metabolic status.	Vitamin D	9-18	CIMT	Homo sapiens	143-147
27198036-9	2016	The effect of vitamin D, K and Ca co-supplementation on maximum levels of left CIMT could be a chance finding.	Vitamin D	14-23	CIMT	Homo sapiens	79-83
25601896-3	2016	Hence, this study was designed to examine whether the administration of vitamin D can influence the plasma level of P-selectin in patients with VTE.	Vitamin D	72-81	selectin P	Homo sapiens	116-126
25601896-6	2016	The plasma level of P-selectin (95% confidence interval = -5.99 to -1.63, P = .022) and hs-CRP (P = .024) significantly declined in vitamin D-treated group, while only hs-CRP was significantly decreased in the control group (P = .011).	Vitamin D	132-141	selectin P	Homo sapiens	20-30
27437780-0	2016	Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women.	Vitamin D	35-44	intelectin 1	Homo sapiens	55-62
27437780-3	2016	The aim of the present study is to investigate how vitamin D levels affect serum vaspin and omentin levels.	Vitamin D	51-60	intelectin 1	Homo sapiens	92-99
27399065-9	2016	Levels of cytochrome P450 (CYP) 27A1 were significantly decreased, whereas levels of CYP24A1 were significantly elevated in cirrhotic patients.These results suggest that decreasing vitamin D levels are likely to be a result, rather than a cause, of liver dysfunction and irrespective of HBV viral load.	Vitamin D	181-190	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	10-36
27337485-6	2016	Prominent here is the vitamin D-dependent antimicrobial pathway common to human macrophages activated by innate and acquired immune responses, mediated by antimicrobial peptides, e.g., cathelicidin, through an interleukin-15- and interleukin-32-dependent common pathway that is necessary for macrophage killing of M. tuberculosis in vitro.	Vitamin D	22-31	interleukin 32	Homo sapiens	230-244
26190642-3	2016	Vitamin D additionally impacts ALS through cell-signalling mechanisms: glutamate, matrix metalloproteinases, the Wnt/beta-catenin signalling pathway, mitogen-activated protein kinase pathways, prostaglandins, reactive oxygen species and nitric oxide synthase, but its role has been only poorly investigated.	Vitamin D	0-9	catenin beta 1	Homo sapiens	117-129
26747961-6	2016	The present article reviews the impact of vitamin D on anti-Mullerian hormone (AMH), as an ovarian reserve marker, and ovarian steroidogenesis.	Vitamin D	42-51	anti-Mullerian hormone	Homo sapiens	79-82
26817629-7	2016	Beneficial actions of treatments with vitamin D or calcitriol on BCa and surrounding adipose tissue included repressed Esr1, aromatase, and Cox2 expression; decreased tumor-derived estrogen and PGE2; reduced expression of leptin receptors; and increased adiponectin receptors.	Vitamin D	38-47	estrogen receptor 1 (alpha)	Mus musculus	119-123
26462119-0	2016	FOXO1 Mediates Vitamin D Deficiency-Induced Insulin Resistance in Skeletal Muscle.	Vitamin D	15-24	forkhead box O1	Mus musculus	0-5
26462119-5	2016	Although sustained activation of forkhead box O1 (FOXO1) in skeletal muscle causes insulin resistance, a relationship between vitamin D deficiency and FOXO1 activation in muscle is unknown.	Vitamin D	126-135	forkhead box O1	Mus musculus	151-156
26911666-8	2016	CONCLUSION: Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naive CHC G4 patients treated with low cost standard therapy.	Vitamin D	12-21	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	49-55
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	aldehyde dehydrogenase 1 family member A3	Homo sapiens	81-88
26858610-1	2015	The distribution of vitamin D-dependent calcium-binding protein (28 kDa calbindin) was investigated in cat lumbar and sacral spinal cord segments (L1-S3).	Vitamin D	20-29	calbindin 1	Homo sapiens	72-81
27764518-11	2016	However, a significant increase in the MOG and CNPase expression was seen in vitamin D injected group as compared to SHAM and control groups.	Vitamin D	77-86	myelin oligodendrocyte glycoprotein	Mus musculus	39-42
27764518-12	2016	It is concluded that vitamin D plays a role in the process of remyelination by increasing MOG and CNPase expression in the cortex.	Vitamin D	21-30	myelin oligodendrocyte glycoprotein	Mus musculus	90-93
27863277-2	2016	Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3).	Vitamin D	0-9	insulin like growth factor binding protein 3	Homo sapiens	65-109
27863277-2	2016	Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3).	Vitamin D	0-9	insulin like growth factor binding protein 3	Homo sapiens	111-117
25777538-12	2016	In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased.	Vitamin D	39-48	transcription factor 4	Mus musculus	174-178
26719974-6	2015	Four of these candidate variants (one each in CXXC1 and RUNX2 and two in LRP5) had a &gt;70% derived allele frequency in East Asians, but were present at lower (20-60%) frequency in Europeans as well, suggesting that the adaptation might have been part of a common response to climatic and dietary changes as humans expanded out of Africa, with implications for their role in vitamin D-dependent bone mineralization and osteoporosis insurgence.	Vitamin D	376-385	CXXC finger protein 1	Homo sapiens	46-51
26885262-5	2015	Further, increased autophagic flux after vitamin D administration was demonstrated by the increase of protein light chain 3 (LC3) conversion both in vivo and in vitro.	Vitamin D	41-50	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	110-123
26885262-5	2015	Further, increased autophagic flux after vitamin D administration was demonstrated by the increase of protein light chain 3 (LC3) conversion both in vivo and in vitro.	Vitamin D	41-50	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	125-128
26885262-6	2015	MEK/ERK and PTEN/PI3K/Akt/mTOR were both found critically involved in vitamin D-induced autophagy.	Vitamin D	70-79	mechanistic target of rapamycin kinase	Mus musculus	26-30
26169817-8	2015	This study provides evidence that vitamin D supplementation has curative effect on pancreas insulin content and on GLUT2 disruption caused by SMF exposure.	Vitamin D	34-43	solute carrier family 2 member 2	Rattus norvegicus	115-120
26949498-10	2015	Vitamin D up-regulated the expression levels of Bcl-2 by (18.87 fold increase), and down-regulated expression of Bax (23%) and FasL (25%).	Vitamin D	0-9	Fas ligand	Homo sapiens	127-131
26224368-3	2015	Among Wnt inhibitors with suitable in vivo biologic activity is vitamin D, which is known to antagonize Wnt/beta-catenin signaling in colorectal cancer and have antitumor activity in PDAC.	Vitamin D	64-73	catenin beta 1	Homo sapiens	108-120
26224368-10	2015	IMPLICATIONS: This study provides a novel biochemical target through which vitamin D signaling exerts inhibitory effects on Wnt/beta-catenin signaling, as well as potential biomarkers for predicting and following tumor response to vitamin D-based therapy.	Vitamin D	75-84	catenin beta 1	Homo sapiens	128-140
26224368-10	2015	IMPLICATIONS: This study provides a novel biochemical target through which vitamin D signaling exerts inhibitory effects on Wnt/beta-catenin signaling, as well as potential biomarkers for predicting and following tumor response to vitamin D-based therapy.	Vitamin D	231-240	catenin beta 1	Homo sapiens	128-140
26770399-7	2015	Both the mean fluorescence intensity and the positive percentage of monocytes TLR4 in the vitamin D group were significantly lower compared to the placebo group, as well as the concentrations of secreted TNF-alpha, IL-6, and IL-1, while the concentration of IL-10 was higher.	Vitamin D	90-99	toll like receptor 4	Homo sapiens	78-82
26071405-0	2015	1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D.	Vitamin D	14-23	leptin	Homo sapiens	81-87
26071405-9	2015	These results imply that vitamin D affects brain serotonin concentrations, which may be relevant to psychiatric disorders, such as autism, and may control leptin levels and affect eating behavior.	Vitamin D	25-34	leptin	Homo sapiens	155-161
26202912-1	2015	STUDY QUESTION: Is there a relationship between serum anti-Mullerian hormone (AMH) levels and seasonal variations in serum vitamin D in ovulatory and polycystic ovary syndrome (PCOS) women?	Vitamin D	123-132	anti-Mullerian hormone	Homo sapiens	78-81
26202912-5	2015	Studies suggest that vitamin D has the ability to modify AMH production in vitro, yet only one clinical study reports the influence of vitamin D on AMH levels.	Vitamin D	21-30	anti-Mullerian hormone	Homo sapiens	57-60
26202912-5	2015	Studies suggest that vitamin D has the ability to modify AMH production in vitro, yet only one clinical study reports the influence of vitamin D on AMH levels.	Vitamin D	135-144	anti-Mullerian hormone	Homo sapiens	148-151
26202912-14	2015	While we acknowledge that a longitudinal study monitoring the relationship between serum AMH and vitamin D in individuals over the four seasons would have been ideal, we believe the current findings are robust as our four seasonal groups did not differ for any significant co-variant for serum AMH or vitamin D (age, BMI, PCOS status or AFC) and that there is no significant association between serum vitamin D concentration and AMH production.	Vitamin D	97-106	anti-Mullerian hormone	Homo sapiens	89-92
25618750-4	2015	RESULTS: VEGF expression in the vitamin D group was similar to that in the OHSS group.	Vitamin D	32-41	vascular endothelial growth factor A	Rattus norvegicus	9-13
25618750-7	2015	Vitamin D effectively increases PEDF, which has an opposing effect on VEGF, which plays a key role in OHSS.	Vitamin D	0-9	vascular endothelial growth factor A	Rattus norvegicus	70-74
26169781-0	2015	Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial.	Vitamin D	9-18	ribosomal oxygenase 2	Homo sapiens	113-117
26180726-10	2015	Additionally, vitamin D may exert an antifibrotic effect partially mediated by MMPs.	Vitamin D	14-23	matrix metallopeptidase 1	Homo sapiens	79-83
26149120-0	2015	Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	78-84
26149120-11	2015	CYP2R1-rs10766197 was significantly associated with the presence of vitamin D deficiency in the Uygur ethnic population (P=0.019, OR=6.533, 95%C.I.	Vitamin D	68-77	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
26149120-16	2015	Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations.	Vitamin D	84-93	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	17-23
25823473-7	2015	Treatment of these professional antigen-presenting cells with vitamin D, a key protective environmental factor in multiple sclerosis, downmodulated CLEC16A in parallel with human leukocyte antigen class II.	Vitamin D	62-71	C-type lectin domain containing 16A	Homo sapiens	148-155
25965341-2	2015	Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development.	Vitamin D	161-170	myelin oligodendrocyte glycoprotein	Mus musculus	96-131
25965341-2	2015	Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development.	Vitamin D	161-170	myelin oligodendrocyte glycoprotein	Mus musculus	133-136
26046091-4	2015	Utilizing latent TB infection (LTBI) as a surrogate of protection, they identified IL-32 as a mediator of interferon gamma (IFNgamma)-vitamin D dependent antimicrobial immunity and a marker of LTBI.	Vitamin D	134-143	interleukin 32	Homo sapiens	83-88
25644204-14	2015	Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency.	Vitamin D	0-9	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	39-45
25773149-6	2015	RESULTS: LAP (TGF-beta) levels increased significantly in the vitamin D treated group from a mean of 47 (SE 11) pg/ml to 55 (SE 14) pg/ml in 12 months (p-value=0.0249).	Vitamin D	62-71	LAP	Homo sapiens	9-12
25773153-0	2015	GM-CSF production by CD4+ T cells in MS patients: regulation by regulatory T cells and vitamin D.	Vitamin D	87-96	colony stimulating factor 2	Homo sapiens	0-6
25773153-10	2015	GM-CSF secretion was susceptible to regulation by Treg and vitamin D.	Vitamin D	59-68	colony stimulating factor 2	Homo sapiens	0-6
25773153-11	2015	Suppression of GM-CSF secretion by vitamin D was reduced in MS patients.	Vitamin D	35-44	colony stimulating factor 2	Homo sapiens	15-21
25773153-13	2015	Furthermore, GM-CSF secretion was prone to regulation by Treg and vitamin D, the latter being less effective in MS patients.	Vitamin D	66-75	colony stimulating factor 2	Homo sapiens	13-19
25750305-6	2015	The average vitamin D level in patients with positive nuclear beta-catenin was 4.58 ng/ml, which was lower than that of patients with negative nuclear beta-catenin expression.	Vitamin D	12-21	catenin beta 1	Homo sapiens	62-74
25750305-6	2015	The average vitamin D level in patients with positive nuclear beta-catenin was 4.58 ng/ml, which was lower than that of patients with negative nuclear beta-catenin expression.	Vitamin D	12-21	catenin beta 1	Homo sapiens	151-163
25713710-7	2015	Moreover, median values of waist circumference, BMI, serum leptin and parathyroid hormone levels were significantly higher in the group with vitamin D deficiency.	Vitamin D	141-150	leptin	Homo sapiens	59-65
25195551-1	2015	BACKGROUND &amp; AIMS: The role of plasma vitamin D deficiency in the development of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) remains poorly understood.	Vitamin D	42-51	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	148-152
25195551-2	2015	Previous studies have suggested a role for vitamin D deficiency in the pathogenesis of NAFLD/NASH, but they have been rather small, and/or NAFLD was diagnosed using only aminotransferases or liver ultrasound.	Vitamin D	43-52	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	93-97
25195551-3	2015	This study aimed to assess the role of vitamin D deficiency in relationship to liver fat accumulation and severity of NASH.	Vitamin D	39-48	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	118-122
24890436-0	2015	UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet.	Vitamin D	125-134	APC, WNT signaling pathway regulator	Mus musculus	97-100
25527766-2	2015	In the Food with vitamin D (VitmaD) study, we showed that common genetic variants rs10741657 and rs10766197 in 25-hydroxylase (CYP2R1) and rs842999 and rs4588 in vitamin D binding protein (GC) predict 25(OH)D concentrations at late summer and after 6-mo consumption of cholecalciferol (vitamin D3)-fortified bread and milk.	Vitamin D	17-26	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	127-133
25527766-9	2015	CONCLUSION: Common genetic variants in the CYP2R1 and GC genes modify 25(OH)D concentrations in the same manner after artificial UVB-induced vitamin D and consumption of vitamin D3-fortified bread and milk.	Vitamin D	141-150	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	43-49
25219681-4	2015	As ancestral humans migrated out of Africa, the evolutionary advantage of MC1R variants may have related to improved cutaneous vitamin D synthesis and higher birthweight reported with certain MC1R variants.	Vitamin D	127-136	melanocortin 1 receptor	Homo sapiens	74-78
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	peroxisome proliferator activated receptor alpha	Homo sapiens	286-290
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	162-169
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	peroxisome proliferator activated receptor alpha	Homo sapiens	286-290
24844860-0	2014	Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage.	Vitamin D	29-38	SKI proto-oncogene	Homo sapiens	8-11
25279717-3	2014	Towards clinical application of vitamin D-induced Tregs in autologous adoptive immunotherapy for type 1 diabetes, we show here that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and TX527 similarly imprint T cells from type 1 diabetes patients with a CD4+ CD25high CD127low regulatory profile, modulate surface expression of skin- and inflammation-homing receptors, and increase expression of CTLA-4 and OX-40.	Vitamin D	32-41	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	386-392
24985146-0	2014	Maternal vitamin D deficiency during pregnancy results in insulin resistance in rat offspring, which is associated with inflammation and Ikappabalpha methylation.	Vitamin D	9-18	NFKB inhibitor alpha	Rattus norvegicus	137-149
23999061-4	2014	In human monocytes (THP-1 cells) the ASAP2 gene is more weakly expressed but more and faster inducible by the biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), than in M2-type macrophages (phorbol ester-differentiated THP-1 cells).	Vitamin D	138-147	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Homo sapiens	37-42
24080249-7	2014	We will review here our studies revealing that 1alpha,25(OH)2D3, an active form of vitamin D, stabilizes 53BP1 levels in tumor cells.	Vitamin D	83-92	tumor protein p53 binding protein 1	Homo sapiens	105-110
24854954-8	2014	In primary human peripheral blood mononuclear cells from 71 prediabetic subjects of a vitamin D(3) intervention study (VitDmet) CD97, LRRC8A, SLC37A2 and NRIP1 can be used as transcriptomic biomarkers for classifying human individuals for their possible benefit from vitamin D(3) supplementation.	Vitamin D	86-95	adhesion G protein-coupled receptor E5	Homo sapiens	128-132
24997768-0	2014	Evaluation of circulating irisin levels in healthy young individuals after a single 100,000 IU vitamin D dose.	Vitamin D	95-104	fibronectin type III domain containing 5	Homo sapiens	26-32
24997768-3	2014	As vitamin D is also known as a key player in that field, we aimed to see if a single dose of 100,000 IU of vitamin D would modify circulating levels of irisin in 29 young adults.	Vitamin D	3-12	fibronectin type III domain containing 5	Homo sapiens	153-159
24997768-3	2014	As vitamin D is also known as a key player in that field, we aimed to see if a single dose of 100,000 IU of vitamin D would modify circulating levels of irisin in 29 young adults.	Vitamin D	108-117	fibronectin type III domain containing 5	Homo sapiens	153-159
24382124-7	2014	After vitamin D replacement, there was significant increase in 25(OH) D levels by 55 3 nmol/l (95% CI 33 3-77 3), reduction in serum parathyroid hormone levels by 3 5 pmol/l (5 8 to -1 2) without change in serum calcium (-0 08 mmol/l, -0 2 to +0 03) and urinary calcium levels (0 72 mmol/24 h, P = 0 2) compared to baseline.	Vitamin D	6-15	tumor protein, translationally-controlled 1	Homo sapiens	294-301
24732451-0	2014	Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma.	Vitamin D	31-40	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	56-62
24851032-9	2014	Leptin levels in vitamin D-deficient patients were statistically significantly higher than in vitamin D-sufficient patients.	Vitamin D	17-26	leptin	Homo sapiens	0-6
24851032-9	2014	Leptin levels in vitamin D-deficient patients were statistically significantly higher than in vitamin D-sufficient patients.	Vitamin D	94-103	leptin	Homo sapiens	0-6
24727903-9	2014	Individuals with vitamin D deficiency had significantly higher levels of serum GM-CSF (p = 0.04), decreased circulating activated CD4+ (p = 0.04) and CD8+ T (p = 0.04) cell frequencies than individuals with sufficient vitamin D levels.	Vitamin D	17-26	colony stimulating factor 2	Homo sapiens	79-85
24378215-9	2014	Moreover, vitamin D deficiency significantly aggravated the decreases in osteocalcin and IGF-1 mRNA by diabetic state.	Vitamin D	10-19	bone gamma-carboxyglutamate protein 2	Mus musculus	73-84
24535566-2	2014	Almost all actions of Vitamin D are mediated by the transcription factor, vitamin D receptor (VDR), which has been widely identified in the central nervous system.	Vitamin D	22-31	vitamin D receptor	Rattus norvegicus	74-92
24535566-2	2014	Almost all actions of Vitamin D are mediated by the transcription factor, vitamin D receptor (VDR), which has been widely identified in the central nervous system.	Vitamin D	22-31	vitamin D receptor	Rattus norvegicus	94-97
24844966-10	2014	The expression of c-fos in periventricular nucleus in VDR knockout mice was higher and it could be inhibited after an injection of vitamin D analog.	Vitamin D	131-140	FBJ osteosarcoma oncogene	Mus musculus	18-23
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	12-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	12-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	183-187
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	141-150	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	141-150	doublesex and mab-3 related transcription factor 1	Homo sapiens	183-187
24517121-2	2014	We aimed to determine and compare the vitamin D status of Saudi adults with and without DMT1.	Vitamin D	38-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	88-92
24517121-6	2014	RESULTS: Both the DMT1 and healthy groups had vitamin D deficiency.	Vitamin D	46-55	doublesex and mab-3 related transcription factor 1	Homo sapiens	18-22
24517121-9	2014	Overall, 100% of the DMT1 adults and 78% of the healthy children were vitamin D deficient.	Vitamin D	70-79	doublesex and mab-3 related transcription factor 1	Homo sapiens	21-25
24517121-10	2014	CONCLUSION: The prevalence of vitamin D deficiency among DMT1 adults was relatively high.	Vitamin D	30-39	doublesex and mab-3 related transcription factor 1	Homo sapiens	57-61
24184224-1	2014	PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population.	Vitamin D	73-82	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	104-110
24464720-0	2014	Toward personalized prevention of obesity: can vitamin D negate the FTO effect?	Vitamin D	47-56	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	68-71
24475177-7	2014	Treatment with vitamin D in the form of 1,25(OH)2D caused significant changes in cell morphology, including thickening of the cell layers (median of 46.5 microm [35.0-69.0] vs. 30 microm [24.5-34.2], p&lt;0.01) and proliferation of cytokeratin-5-expressing cells, as demonstrated by immunohistochemical analysis.	Vitamin D	15-24	keratin 5	Homo sapiens	232-245
24475177-8	2014	Similar effects were seen for 25(OH)D. In addition to altering morphology, higher concentrations of vitamin D significantly upregulated small proline-rich protein (SPRR1beta) expression (6.3 fold-induction, p&lt;0.01), suggestive of squamous metaplasia.	Vitamin D	100-109	small proline rich protein 1B	Homo sapiens	164-173
24200978-1	2014	Previous studies have identified several common genetic variants in VDR, GC and CYP2R1 to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D deficiency in Western populations.	Vitamin D	141-150	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	80-86
24245571-3	2013	Concerning the synthesis of vitamin D, the hydroxylases CYP2R1, CYP27B1 and CYP24A1 play a critical role, and the latter molecule determines the biological half-life of 1,25(OH)2 D3 , which is synthesized in the proximal renal tubules.	Vitamin D	28-37	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	56-62
24245571-9	2013	CONCLUSION: We thus conclude that upregulated gene expression of the catabolizing CYP24A1 as well as the synthesizing CYP2R1 and CYP27B1 may lead to a misbalance of vitamin D metabolites in ccRCC and thus contributing to its pathogenesis.	Vitamin D	165-174	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	118-124
23360833-1	2013	BACKGROUND: In HIV-infected adults, we and others have shown that vitamin D deficiency is independently associated with increased carotid intima-media thickness (cIMT), a surrogate marker for cardiovascular disease (CVD).	Vitamin D	66-75	CIMT	Homo sapiens	162-166
23789983-10	2013	Current evidence indicates that, in breast tumours, vitamin D modulates the IGF-I/IGFBP ratio to decrease proliferation and increase apoptosis.	Vitamin D	52-61	insulin like growth factor binding protein 3	Homo sapiens	82-87
24073854-3	2013	Our study aimed to identify the relationship between three vitamin D-related genes (group specific component [GC], cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1), and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and rickets in Han Chinese children from northeastern China.	Vitamin D	59-68	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	115-168
24073854-3	2013	Our study aimed to identify the relationship between three vitamin D-related genes (group specific component [GC], cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1), and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and rickets in Han Chinese children from northeastern China.	Vitamin D	59-68	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	170-176
24084050-8	2013	Two variants: rs731236[A] (VDR) and rs732594[A] (SCUBE3) showed a significant association with serum Vit D levels in CD patients.	Vitamin D	101-106	signal peptide, CUB domain and EGF like domain containing 3	Homo sapiens	49-55
24084050-9	2013	Four variants: rs7975232[A] (VDR), rs732594[A] (SCUBE3), and rs2980[T] and rs2981[A] (PHF-11) showed a significant association with serum Vit D levels in the control group.	Vitamin D	138-143	signal peptide, CUB domain and EGF like domain containing 3	Homo sapiens	48-54
24040225-6	2013	A similar pattern was previously observed in the MC1R gene and concurs with UV radiation-driven model of skin color evolution by which mutations leading to lower melanin levels and decreased photoprotection are subject to purifying selection at low latitudes while being tolerated or even favored at higher latitudes because they facilitate UV-dependent vitamin D production.	Vitamin D	354-363	melanocortin 1 receptor	Homo sapiens	49-53
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	insulin receptor substrate 1	Mus musculus	129-134
23621113-12	2013	On the basis of the present findings, vitamin D does not aid glucose transport across cells of liver and adipose tissues, the major insulin-sensitive tissues, in HFD-fed mice; however, it appears to enhance the intracellular mechanisms of insulin action mediated by IRS-1 and VDR in muscle tissue.	Vitamin D	38-47	insulin receptor substrate 1	Mus musculus	266-271
23595236-12	2013	Based on these data, it can be concluded that vitamin D increases TSLP expression in 16-HBE cells through the VDUP1 pathway, which suggests a novel mechanism by which vitamin D alters immune function in the lungs.	Vitamin D	46-55	thymic stromal lymphopoietin	Homo sapiens	66-70
23595236-12	2013	Based on these data, it can be concluded that vitamin D increases TSLP expression in 16-HBE cells through the VDUP1 pathway, which suggests a novel mechanism by which vitamin D alters immune function in the lungs.	Vitamin D	167-176	thymic stromal lymphopoietin	Homo sapiens	66-70
23220095-12	2013	These results suggest that a long-term exposure of osteoblasts to vitamin D compounds down-regulate RANKL expression.	Vitamin D	66-75	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	100-105
23065434-7	2013	Serum leptin levels (12.9 +- 17.6 ng/ml) significantly increased (18.1 +- 19.5 ng/ml) (p &lt; 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement.	Vitamin D	178-187	leptin	Homo sapiens	6-12
23047203-1	2013	BACKGROUND: Recent data suggest a potential role of testis in vitamin D activation, where Leydig cells could represent key players in this process since they express the highest amount of CYP2R1, a key enzyme involved in vitamin D 25 hydroxylation.	Vitamin D	62-71	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	188-194
23047203-1	2013	BACKGROUND: Recent data suggest a potential role of testis in vitamin D activation, where Leydig cells could represent key players in this process since they express the highest amount of CYP2R1, a key enzyme involved in vitamin D 25 hydroxylation.	Vitamin D	221-230	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	188-194
23569273-4	2013	In this study, we found that active vitamin D reduced the expression of S1PR2, a chemorepulsive receptor for blood S1P, on circulating osteoclast precursor monocytes both in vitro and in vivo.	Vitamin D	36-45	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
23352937-6	2013	The nuclear expression of VDR in TH-positive neurons during critical periods of brain development suggests that alterations in early life vitamin D status may influence the orderly development of dopaminergic neurons.	Vitamin D	138-147	vitamin D receptor	Rattus norvegicus	26-29
23570271-5	2013	Genetic studies have provided an opportunity to identify the proteins that link vitamin D to ALS pathology, including major histocompatibility complex (MHC) class II molecules, toll-like receptors, poly(ADP-ribose) polymerase-1, heme oxygenase-1, and calcium-binding proteins, as well as the reduced form of nicotinamide adenine dinucleotide phosphate.	Vitamin D	80-89	heme oxygenase 1	Homo sapiens	229-245
23570271-6	2013	Vitamin D also exerts its effect on ALS through cell-signaling mechanisms, including glutamate, matrix metalloproteinases, mitogen-activated protein kinase pathways, the Wnt/beta-catenin signaling pathway, prostaglandins, reactive oxygen species, and nitric oxide synthase.	Vitamin D	0-9	catenin beta 1	Homo sapiens	174-186
22955340-0	2013	Associations of circulating 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and vitamin D pathway genes with prostate-specific antigen progression in men with localized prostate cancer undergoing active monitoring.	Vitamin D	38-47	kallikrein related peptidase 3	Homo sapiens	107-132
22955340-2	2013	We examined whether the measures of vitamin D were associated with prostate-specific antigen (PSA) doubling time in men undergoing active monitoring.	Vitamin D	36-45	kallikrein related peptidase 3	Homo sapiens	67-98
23361158-11	2013	In vitro results confirm an MCP-1-lowering effect of vitamin D.	Vitamin D	53-62	C-C motif chemokine ligand 2	Homo sapiens	28-33
23361158-12	2013	Future studies should determine if vitamin D-mediated reductions in MCP-1 concentrations reflect improved clinical outcomes.	Vitamin D	35-44	C-C motif chemokine ligand 2	Homo sapiens	68-73
23114382-6	2013	Recent advances in the methodology of large-scale genetic association studies, including coordinated international collaboration, have identified associations of CG, DHCR1, CYP2R1, VDR, and CYP24A1 with serum levels of vitamin D.	Vitamin D	219-228	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	173-179
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	PCNA clamp associated factor	Homo sapiens	141-144
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	PCNA clamp associated factor	Homo sapiens	166-169
23460889-3	2013	Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes.	Vitamin D	82-91	filaggrin	Homo sapiens	34-43
23460889-7	2013	Filaggrin genotype was used as instrumental variable for vitamin D status.	Vitamin D	57-66	filaggrin	Homo sapiens	0-9
23243403-5	2012	Correlations were assessed using Pearson r. RESULTS: In patients without VitDd (25OHD &gt;= 20 ng/mL), ESSs was inversely correlated with vitamin D concentration (r = 0.45, p &lt; 0.05).	Vitamin D	138-147	NADH:ubiquinone oxidoreductase subunit B11	Homo sapiens	103-107
23128285-10	2012	INTERPRETATION: Compared with controls, the offspring of nonagenarians who had at least one nonagenarian sibling had a reduced frequency of a common variant in the CYP2R1 gene, which predisposes people to high vitamin D levels; they also had lower levels of vitamin D that persisted over the 2 most prevalent genotypes.	Vitamin D	210-219	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	164-170
23128285-10	2012	INTERPRETATION: Compared with controls, the offspring of nonagenarians who had at least one nonagenarian sibling had a reduced frequency of a common variant in the CYP2R1 gene, which predisposes people to high vitamin D levels; they also had lower levels of vitamin D that persisted over the 2 most prevalent genotypes.	Vitamin D	258-267	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	164-170
22576297-8	2012	Homozygous carriers of the rare DHCR7 allele or the common CYP2R1 allele presented with reduced 25(OH)-vitamin D levels (P &lt; 0.05).	Vitamin D	103-112	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	59-65
22221397-9	2012	We demonstrated that the restoring effect of vitamin D(3) is mediated through VDR modulation, thereby improving signal transduction and controlling free radicals in the liver of diabetic rats.	Vitamin D	45-54	vitamin D receptor	Rattus norvegicus	78-81
22964475-1	2012	APC/beta-catenin pathway perturbation is a common early event in colorectal carcinogenesis and is affected by calcium and vitamin D in basic science studies.	Vitamin D	122-131	catenin beta 1	Homo sapiens	4-16
22964475-5	2012	In the vitamin D(3)-supplemented group relative to placebo, the proportion of APC in the upper 40% of crypts (Phih APC) increased 21% (P = 0.01), beta-catenin decreased 12% (P = 0.18), E-cadherin increased 72% (P = 0.03), and the Phih APC/beta-catenin ratio (APC/beta-catenin score) increased 31% (P = 0.02).	Vitamin D	7-16	catenin beta 1	Homo sapiens	146-158
22964475-5	2012	In the vitamin D(3)-supplemented group relative to placebo, the proportion of APC in the upper 40% of crypts (Phih APC) increased 21% (P = 0.01), beta-catenin decreased 12% (P = 0.18), E-cadherin increased 72% (P = 0.03), and the Phih APC/beta-catenin ratio (APC/beta-catenin score) increased 31% (P = 0.02).	Vitamin D	7-16	catenin beta 1	Homo sapiens	239-251
22964475-5	2012	In the vitamin D(3)-supplemented group relative to placebo, the proportion of APC in the upper 40% of crypts (Phih APC) increased 21% (P = 0.01), beta-catenin decreased 12% (P = 0.18), E-cadherin increased 72% (P = 0.03), and the Phih APC/beta-catenin ratio (APC/beta-catenin score) increased 31% (P = 0.02).	Vitamin D	7-16	catenin beta 1	Homo sapiens	239-251
22899855-0	2012	MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.	Vitamin D	33-42	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	98-103
22899855-1	2012	Vitamin D(3,) and its most active form, 1,25(OH)(2)D(3), are well known to stimulate osteoclastogenesis through stromal cell induction of the receptor activator of nuclear factor-kappaB ligand (RANKL).	Vitamin D	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	142-192
22899855-1	2012	Vitamin D(3,) and its most active form, 1,25(OH)(2)D(3), are well known to stimulate osteoclastogenesis through stromal cell induction of the receptor activator of nuclear factor-kappaB ligand (RANKL).	Vitamin D	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	194-199
22841360-8	2012	Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT (P = 0.001), lower ABI (P &lt; 0.001) and higher hs-CRP (P = 0.022).	Vitamin D	102-111	CIMT	Homo sapiens	146-150
22993666-0	2012	Relationship between vitamin D and IL-23, IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians.	Vitamin D	21-30	C-C motif chemokine ligand 2	Homo sapiens	52-88
22993666-1	2012	AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1).	Vitamin D	15-24	C-C motif chemokine ligand 2	Homo sapiens	105-141
22993666-1	2012	AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1).	Vitamin D	15-24	C-C motif chemokine ligand 2	Homo sapiens	143-148
22993666-20	2012	IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected.	Vitamin D	142-151	interleukin 23 subunit alpha	Homo sapiens	0-5
22993666-20	2012	IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected.	Vitamin D	142-151	C-C motif chemokine ligand 2	Homo sapiens	174-179
22710747-6	2012	One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade.	Vitamin D	104-113	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	131-138
22532985-3	2012	Vitamin D has also been implicated in asthma through its effects on the obesity, bacillus Calmettee Guerin (BCG) vaccination and high vitamin D level, vitamin D supplement, checkpoint protein kinase 1 (Chk1), plasminogen activator inhibitor-1 (PAI-1) and gamma delta T cells (gdT).	Vitamin D	0-9	serpin family E member 1	Homo sapiens	209-242
22532985-3	2012	Vitamin D has also been implicated in asthma through its effects on the obesity, bacillus Calmettee Guerin (BCG) vaccination and high vitamin D level, vitamin D supplement, checkpoint protein kinase 1 (Chk1), plasminogen activator inhibitor-1 (PAI-1) and gamma delta T cells (gdT).	Vitamin D	0-9	serpin family E member 1	Homo sapiens	244-249
22649903-0	2012	AOAC SMPR 2011.004: Standard method performance requirements for vitamin D in infant formula and adult/pediatric nutritional formula.	Vitamin D	65-74	mannose-6-phosphate receptor, cation dependent	Homo sapiens	5-9
22619734-4	2012	Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor.	Vitamin D	66-75	heme oxygenase 1	Homo sapiens	267-283
23029160-3	2012	Exogenous vitamin D increased Ca(2+) influx and expressions of ecac and 25-hydroxyvitamin D(3)-24-hydroxylase (cyp24a1), but downregulated 1alpha-OHase (cyp27b1) with no effects on other Ca(2+) transporters.	Vitamin D	10-19	cytochrome P450, family 24, subfamily A, polypeptide 1	Danio rerio	111-118
22536373-5	2012	Mice treated with the low vitamin D diet had more calcified lesions and a higher expression of Msx2, Bmp2, and Runx2 in aortic roots than mice fed recommended or high amounts of vitamin D (P&lt;0.001).	Vitamin D	26-35	runt related transcription factor 2	Mus musculus	111-116
22442690-8	2012	The factor causing inhibition of TLR4-mediated IL-12p70 production by cord blood plasma was resistant to heat inactivation or protein depletion and was independent of IL-10, vitamin D and prostaglandin E2.	Vitamin D	174-183	toll like receptor 4	Homo sapiens	33-37
22112050-2	2011	When bound to a variety of vitamin D analogues, VDR manifests a wide diversity of physiological actions.	Vitamin D	27-36	vitamin D receptor	Rattus norvegicus	48-51
21723567-12	2011	Finally, 1,25(OH)(2) Vitamin D also increased the expression and biological activity of IDO, triggering significant increase in the number of CD4+CD25+ T regulatory cells.	Vitamin D	21-30	indoleamine 2,3-dioxygenase 1	Homo sapiens	88-91
21735060-0	2011	SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D.	Vitamin D	59-68	serum/glucocorticoid regulated kinase 1	Mus musculus	0-4
21735060-2	2011	In squamous carcinoma cells, SGK1 expression is stimulated by 1,25(OH)2D3, the biologically active metabolite of vitamin D.	Vitamin D	113-122	serum/glucocorticoid regulated kinase 1	Mus musculus	29-33
21735060-7	2011	vitamin D), the SGK1 transcript levels as well as the SGLT1 protein abundance were increased in sgk1(+/+) mice.	Vitamin D	0-9	serum/glucocorticoid regulated kinase 1	Mus musculus	96-100
21735060-9	2011	Furthermore, an oral glucose load was followed by an increase in the plasma glucose concentration to significantly higher values in sgk1(+/+) mice treated with a vitamin D-rich diet than in untreated sgk1(+/+) mice.	Vitamin D	162-171	serum/glucocorticoid regulated kinase 1	Mus musculus	132-136
21735060-10	2011	In conclusion, vitamin D treatment upregulates the expression of SGK1, which in turn enhances SGLT1 activity.	Vitamin D	15-24	serum/glucocorticoid regulated kinase 1	Mus musculus	65-69
21441443-6	2011	We replicated the associations of four vitamin D metabolism genes (GC, DHCR7, CYP2R1, and CYP24A1) with 25(OH)D in control subjects.	Vitamin D	39-48	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	78-84
21156217-5	2011	In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p&lt;0.001), IL-23 (p=0.011), IL-10 (p=0.033) cytokine levels, TM (p=0.001) and endothelin (p=0.033) levels.	Vitamin D	26-35	interleukin 23 subunit alpha	Homo sapiens	99-104
20855290-1	2011	The nuclear receptor vitamin D receptor (VDR) is known to associate with two vitamin D response element (VDRE) containing chromatin regions of the insulin-like growth factor binding protein 3 (IGFBP3) gene.	Vitamin D	21-30	insulin like growth factor binding protein 3	Homo sapiens	147-191
20855290-1	2011	The nuclear receptor vitamin D receptor (VDR) is known to associate with two vitamin D response element (VDRE) containing chromatin regions of the insulin-like growth factor binding protein 3 (IGFBP3) gene.	Vitamin D	21-30	insulin like growth factor binding protein 3	Homo sapiens	193-199
20876762-3	2010	Normally, renal reabsorption of vitamin D-binding protein-bound 25D(3) absolutely requires receptor-mediated endocytosis via a receptor complex containing megalin, cubilin, and disabled-2 (Dab2), whereas an absence of megalin or its endocytic partners can lead to a marked urinary loss of 25D and severe vitamin D deficiency.	Vitamin D	32-41	cubilin	Rattus norvegicus	164-171
20013077-6	2010	One (p21 VDRE Luc) has the vitamin D response element (VDRE) in the p21 promoter region; the other (p21 NO-VDRE Luc) does not.	Vitamin D	27-36	H3 histone pseudogene 16	Homo sapiens	5-8
20013077-6	2010	One (p21 VDRE Luc) has the vitamin D response element (VDRE) in the p21 promoter region; the other (p21 NO-VDRE Luc) does not.	Vitamin D	27-36	H3 histone pseudogene 16	Homo sapiens	68-71
20013077-6	2010	One (p21 VDRE Luc) has the vitamin D response element (VDRE) in the p21 promoter region; the other (p21 NO-VDRE Luc) does not.	Vitamin D	27-36	H3 histone pseudogene 16	Homo sapiens	68-71
20723601-6	2010	Vitamin D(3) metabolites increased ALP activity and induced mineralization when osteogenic supplements (OS; l-ascorbic acid-2-phosphate+beta-glycerophosphate) were added, though the expression of osteocalcin (OC) and osteopontin (OPN) were regulated without the addition of OS.	Vitamin D	0-9	secreted phosphoprotein 1	Homo sapiens	217-228
20723601-6	2010	Vitamin D(3) metabolites increased ALP activity and induced mineralization when osteogenic supplements (OS; l-ascorbic acid-2-phosphate+beta-glycerophosphate) were added, though the expression of osteocalcin (OC) and osteopontin (OPN) were regulated without the addition of OS.	Vitamin D	0-9	secreted phosphoprotein 1	Homo sapiens	230-233
20711952-0	2010	Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells.	Vitamin D	0-9	insulin like growth factor binding protein 1	Homo sapiens	40-84
20711952-0	2010	Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells.	Vitamin D	0-9	insulin like growth factor binding protein 1	Homo sapiens	86-93
20581062-9	2010	These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans, the ASARM peptide may be involved in the mineralization defects and the PHEX-MEPE interaction may be indirect, as ensuring a better phosphate and vitamin D environment to the mineralizing dentin prevents MEPE cleavage.	Vitamin D	246-255	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	172-176
20435648-4	2010	RESULTS: CD14 was up-regulated, whereas TLR2, TLR4 and TLR9 expression was down-regulated by vitamin D(3) exposure in a time-dependent manner.	Vitamin D	93-102	toll like receptor 4	Homo sapiens	46-50
20304051-2	2010	The objective was to measure the effect of vitamin D supplementation, in vitamin D deficient women (25(OH)D concentration&lt;50 nmol/L), on osteocalcin (OC) and C-telopeptide (CTX).	Vitamin D	43-52	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	176-179
20156263-3	2010	Vitamin D acts through a nuclear receptor (VDR) and increases the expression of receptor activator of nuclear factor-kappaB ligand (rankl) and muscle segment homeobox 2 (msx2) genes.	Vitamin D	0-9	vitamin D receptor	Felis catus	43-46
20156263-10	2010	However, increased expression of VDR protein, and the relative gene expression levels of 1alpha-hydroxylase and the VDR-target gene, 24-hydroxylase, indicated the involvement of an active vitamin D signalling in the pathophysiology of tooth resorption in cats.	Vitamin D	188-197	vitamin D receptor	Felis catus	33-36
20156263-10	2010	However, increased expression of VDR protein, and the relative gene expression levels of 1alpha-hydroxylase and the VDR-target gene, 24-hydroxylase, indicated the involvement of an active vitamin D signalling in the pathophysiology of tooth resorption in cats.	Vitamin D	188-197	vitamin D receptor	Felis catus	116-119
20089040-0	2010	Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2"-deoxycytidine-induced PTEN upregulation.	Vitamin D	0-9	phosphatase and tensin homolog	Homo sapiens	146-150
20089040-2	2010	Here we show that 1,25-dihydroxyvitamin D3 (VD3, the active form of vitamin D) significantly promoted apoptosis in the undifferentiated gastric cancer cell line HGC-27, and this was accompanied by a concurrent increase in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on VD3 treatment.	Vitamin D	32-41	phosphatase and tensin homolog	Homo sapiens	279-283
20089040-6	2010	Furthermore, we found that the histone deacetylase inhibitors trichostatin A and sodium butyrate and the methylation inhibitor 5-aza-2"-deoxycytidine played important roles in vitamin D-induced apoptosis through PTEN upregulation.	Vitamin D	176-185	phosphatase and tensin homolog	Homo sapiens	212-216
21139376-1	2010	The biologically active form of vitamin D, 1alpha,25-dihydroxy vitamin D3 (VD), regulates the synthesis of the bone Ca-binding proteins osteocalcin and osteopontin.	Vitamin D	32-41	secreted phosphoprotein 1	Homo sapiens	152-163
19852851-3	2009	METHODS: Eleven candidate genes were chosen for this study, five of which code for proteins in the vitamin D metabolism pathway (CYP27A1, CYP27B1, CYP2R1, CYP24A1, GC) and six that are known to be transcriptionally regulated by vitamin D (IL10, IL1RL1, CD28, CD86, IL8, SKIIP).	Vitamin D	99-108	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	129-136
19852851-3	2009	METHODS: Eleven candidate genes were chosen for this study, five of which code for proteins in the vitamin D metabolism pathway (CYP27A1, CYP27B1, CYP2R1, CYP24A1, GC) and six that are known to be transcriptionally regulated by vitamin D (IL10, IL1RL1, CD28, CD86, IL8, SKIIP).	Vitamin D	99-108	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	147-153
19414624-8	2009	Higher protein expression of CYP3A4, MRP2, P-gp, and MRP4 was also observed after a 6-day treatment with other vitamin D analogs (100 nM 1alpha-hydroxyvitamin D(3),1alpha-hydroxyvitamin D(2) or Hectorol, and 25-hydroxyvitamin D(3)) in Caco-2 cells, suggesting a role of 1,25(OH)(2)D(3) and analogs in the activation of enzymes and transporters via the vitamin D receptor.	Vitamin D	111-120	phosphoglycolate phosphatase	Homo sapiens	43-47
19423536-5	2009	Among cases, but not controls, average MLH1 expression tended to be higher with current alcohol consumption, regular aspirin use, and higher total intakes of calcium, vitamin D, and folate.	Vitamin D	167-176	mutL homolog 1	Homo sapiens	39-43
18981260-3	2009	Vitamin D(3) activates the CYP24A1 promoter by dissociating the corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D receptor (VDR) on those VDREs.	Vitamin D	0-9	nuclear receptor co-repressor 2	Mus musculus	139-143
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	23-32	nuclear receptor co-repressor 2	Mus musculus	153-157
19642305-4	2009	Overproduction of cytokines IL-1 alpha, IL-1 beta and TNF-alpha increases bone resorption, which is further accelerated by hyperparathyroidism connected with malabsorption of calcium and vitamin D.	Vitamin D	187-196	interleukin 1 alpha	Homo sapiens	28-38
22461093-5	2009	Further examples include screening the presence of the HLA-B*5701 allele to prevent the hypersensitivity reactions to abacavir and the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therapy of breast cancer or that of KRAS mutation status for cetuximab or panitumumab therapy in colorectal cancer.Moreover, the application of pharmacogenetics and pharmacogenomics to therapies used in the treatment of osteoarticular diseases (e.g. rheumatoid arthritis, osteoporosis) holds great promise for tailoring therapy with clinically relevant drugs (e.g. disease-modifying antirheumatic drugs, vitamin D, and estrogens).	Vitamin D	631-640	major histocompatibility complex, class I, B	Homo sapiens	55-60
18649741-2	2008	The enzymes that are responsible for the activation of vitamin D to 1alpha,25(OH)2D include vitamin D-25-hydroxylase (25-OHase) and 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase or CYP27BJ) and are present in cultured prostate cells.	Vitamin D	55-64	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	92-116
18502255-11	2008	In those with vitamin D insufficiency, we found small decreases in Apo A-II in the treated relative to the control group.	Vitamin D	14-23	apolipoprotein A2	Homo sapiens	67-75
17881271-9	2008	GH-induced STAT5b phosphorylation levels were similar to basal values in transgenic mice liver treated with or without vitamin D; the refractoriness to GH was also present in muscle.	Vitamin D	119-128	growth hormone	Mus musculus	0-2
18182164-1	2008	We investigated the role of Heat shock protein 90 (Hsp90) in vitamin D action in Caco-2 cells using geldanamycin (GA) to block Hsp90 function and RNA interference to reduce Hsp90beta expression.	Vitamin D	61-70	heat shock protein 90 alpha family class A member 1	Homo sapiens	28-49
18182164-1	2008	We investigated the role of Heat shock protein 90 (Hsp90) in vitamin D action in Caco-2 cells using geldanamycin (GA) to block Hsp90 function and RNA interference to reduce Hsp90beta expression.	Vitamin D	61-70	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
18182164-7	2008	These findings indicate that Hsp90beta is needed for optimal vitamin D responsiveness in the enterocyte and demonstrate a specific role for Hsp90beta in VDR signaling.	Vitamin D	61-70	heat shock protein 90 alpha family class B member 1	Homo sapiens	29-38
17607662-0	2007	CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans.	Vitamin D	8-17	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
17607662-2	2007	CYP2R1, a cytochrome P450 enzyme, catalyzes the formation of vitamin D3 to 25-hydroxyvitamin D3 (25(OH)D3), the main circulating vitamin D metabolite.	Vitamin D	61-70	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
17976080-4	2007	Megalin knockout mice revealed impaired osteogenesis due to vitamin D deficiency.	Vitamin D	60-69	low density lipoprotein receptor-related protein 2	Mus musculus	0-7
17221218-9	2007	Our results also suggest a connection between CCHCR1 and vitamin D metabolism in keratinocytes.	Vitamin D	57-66	coiled-coil alpha-helical rod protein 1	Homo sapiens	46-52
17221218-13	2007	Taken the role of steroid hormones, including vitamin D and estrogen, in cell proliferation, epidermal barrier homeostasis, differentiation, and immune response, our results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism.	Vitamin D	46-55	coiled-coil alpha-helical rod protein 1	Homo sapiens	193-199
17215122-4	2007	There was marginal vitamin D deficiency (&lt;37 nmol/L 25(OH)D) in 63% of Vietnamese but only in 37% of Australian/British born.	Vitamin D	19-28	immunoglobulin kappa variable 3D-7	Homo sapiens	53-62
17223343-7	2007	The prepared Vitamin D analog 6 exhibited limited binding ability to the rat intestinal Vitamin D receptor being ca.	Vitamin D	13-22	vitamin D receptor	Rattus norvegicus	88-106
16737686-5	2006	Moreover, while the Gemini Vitamin D(3) analog Ro3582 modulated the expression of several Vitamin D target genes such as the 24-hydroxylase, CD14, osteocalcin, and osteopontin in both cell lines, Ro3582 regulated many genes involved in cell proliferation and apoptosis, cell adhesion, invasion, angiogenesis as well as cell signaling pathways, such as the BMP and TGF-beta systems, differently in the two cell lines.	Vitamin D	27-36	secreted phosphoprotein 1	Homo sapiens	164-175
16737686-5	2006	Moreover, while the Gemini Vitamin D(3) analog Ro3582 modulated the expression of several Vitamin D target genes such as the 24-hydroxylase, CD14, osteocalcin, and osteopontin in both cell lines, Ro3582 regulated many genes involved in cell proliferation and apoptosis, cell adhesion, invasion, angiogenesis as well as cell signaling pathways, such as the BMP and TGF-beta systems, differently in the two cell lines.	Vitamin D	90-99	secreted phosphoprotein 1	Homo sapiens	164-175
16289173-11	2006	Collectively, these studies demonstrate that a non-genotropic effect due to a direct interaction of the androgen receptor with EGFR and to a rapid effect of a Vitamin D agonist on KGFR may disrupt signalling of GF leading to decreased tumorigenicity and a less malignant phenotype of PC cells in vitro.	Vitamin D	159-168	fibroblast growth factor receptor 2	Homo sapiens	180-184
16431339-7	2006	Critically low vitamin D levels (&lt;10 ng/ml) were found in 22 of the SLE cases, with presence of renal disease being the strongest predictor (OR 13.3, p&lt;0.01) followed by photosensitivity (OR 12.9, p&lt;0.01).	Vitamin D	15-24	olfactory receptor family 2 subfamily G member 3	Homo sapiens	144-151
16424941-0	2006	c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs.	Vitamin D	61-70	FBJ osteosarcoma oncogene	Mus musculus	0-5
16424941-5	2006	By screening vitamin D analogs based on their c-Fos-suppressing activity, we identified a new analog, named DD281, that inhibited bone resorption and prevented bone loss in ovariectomized mice, more potently than 1alpha,25(OH)2D3, with similar levels of calcium absorption.	Vitamin D	13-22	FBJ osteosarcoma oncogene	Mus musculus	46-51
16353199-12	2006	There were no significant changes in galectin-3 staining, but a striking reduction in MUC5AC mucin staining in polyps was observed after treatment with calcium plus vitamin D.	Vitamin D	165-174	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	86-92
16397276-7	2006	This is the first study to report that the negative relation of vitamin D and calcium intakes with breast density may be seen primarily among women with high IGF-I or high IGFBP-3 levels.	Vitamin D	64-73	insulin like growth factor binding protein 3	Homo sapiens	172-179
16126938-8	2005	The NR ligands, vitamin D(3), trans/cis RA, glucocorticoids, and thiazolidines, induce dramatic changes in the physiology of cells harboring high Wnt/beta-catenin/Tcf activity.	Vitamin D	16-25	catenin beta 1	Homo sapiens	150-162
16213938-2	2005	However, vitamin D(3) can differentiate the CD34(+) cells into immune stimulatory dendritic cells.	Vitamin D	9-18	CD34 antigen	Mus musculus	44-48
16186133-3	2005	In silico screening of the 174 kb of genomic sequence surrounding all six IGFBP genes identified 15 candidate vitamin D response elements (VDREs) close to or in IGFBP1, 2, 3 and 5 but not in the IGFBP4 and 6 genes.	Vitamin D	110-119	insulin like growth factor binding protein 1	Homo sapiens	74-79
16186133-3	2005	In silico screening of the 174 kb of genomic sequence surrounding all six IGFBP genes identified 15 candidate vitamin D response elements (VDREs) close to or in IGFBP1, 2, 3 and 5 but not in the IGFBP4 and 6 genes.	Vitamin D	110-119	insulin like growth factor binding protein 1	Homo sapiens	161-167
15746989-14	2005	This study supports the hypothesis that prolongation of VDR half-life increases VDR tissue levels and mediates increased VDR-regulated genes that result in hypercalciuria through actions on vitamin D-regulated calcium transport in intestine, bone, and kidney.	Vitamin D	190-199	vitamin D receptor	Rattus norvegicus	56-59
15574355-12	2005	Surprisingly, more than 70 % of the vitamin D metabolites observed in a living body were found to be the products formed by the activities of CYP27A1, CYP27B1 and CYP24A1.	Vitamin D	36-45	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	142-149
15465040-0	2004	Metabolism of vitamin D by human microsomal CYP2R1.	Vitamin D	14-23	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	44-50
15465040-4	2004	Thus, vitamin D metabolism by CYP2R1 was compared with human mitochondrial CYP27A1, which used to be considered a physiologically important vitamin D(3) 25-hydroxylase.	Vitamin D	6-15	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	30-36
15465040-5	2004	A clear difference was observed between CYP2R1 and CYP27A1 in the metabolism of vitamin D(2).	Vitamin D	80-89	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	40-46
15465040-5	2004	A clear difference was observed between CYP2R1 and CYP27A1 in the metabolism of vitamin D(2).	Vitamin D	80-89	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	51-58
15465040-6	2004	CYP2R1 hydroxylated vitamin D(2) at the C-25 position while CYP27A1 hydroxylated it at positions C-24 and C-27.	Vitamin D	20-29	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	0-6
15465040-7	2004	The K(m) and k(cat) values for the CYP2R1-dependent 25-hydroxylation activity toward vitamin D(3) were 0.45microM and 0.97min(-1), respectively.	Vitamin D	85-94	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	35-41
15465040-9	2004	These results strongly suggest that CYP2R1 plays a physiologically important role in the vitamin D 25-hydroxylation in humans.	Vitamin D	89-98	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	36-42
15322208-8	2004	However, VDR-deficient mice failed to develop experimental allergic asthma, suggesting an important role for the vitamin D endocrine system in the generation of Th2-driven inflammation in the lung.	Vitamin D	113-122	heart and neural crest derivatives expressed 2	Mus musculus	161-164
15225784-7	2004	Both DRIP205 and SRC-3 potentiated Vitamin D-induced transcription in proliferating cells, but during differentiation, DRIP205 was no longer effective.	Vitamin D	35-44	nuclear receptor coactivator 3	Homo sapiens	17-22
15225797-8	2004	The results indicate that the vitamin D analog JKF upregulates the response and sensitivity of vascular tissues to E(2), in association with increased expression of their ERalpha.	Vitamin D	30-39	estrogen receptor 1	Rattus norvegicus	171-178
15225809-1	2004	Although it was originally proposed that the major role of calbindin is to facilitate the vitamin D dependent movement of calcium through the cytosolic compartment of the intestinal or renal cell, we found that calbindin also has a major role in different cell types in protecting against apoptotic cell death.	Vitamin D	90-99	calbindin 1	Homo sapiens	59-68
15225809-1	2004	Although it was originally proposed that the major role of calbindin is to facilitate the vitamin D dependent movement of calcium through the cytosolic compartment of the intestinal or renal cell, we found that calbindin also has a major role in different cell types in protecting against apoptotic cell death.	Vitamin D	90-99	calbindin 1	Homo sapiens	211-220
14523025-14	2003	These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.	Vitamin D	64-73	osteocrin	Mus musculus	27-36
14572661-3	2003	The inhibition of DC differentiation by dexamethasone or vitamin D(3) treatment down-regulated the expression of the NDRG2 gene in DCs.	Vitamin D	57-66	NDRG family member 2	Homo sapiens	117-122
13679819-0	2003	Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.	Vitamin D	16-25	heart and neural crest derivatives expressed 2	Mus musculus	52-55
13679819-9	2003	RESULTS: Early treatment with vitamin D augmented allergen-induced T-cell proliferation along with T(H)2 cytokine (IL-4 and IL-13) and IgE production.	Vitamin D	30-39	interleukin 4	Mus musculus	115-119
12951895-14	2003	Vitamin D caused a concentration-dependent decrease in IFN-gamma response and an increase in TNF-alpha response in PWM-stimulated cultures.	Vitamin D	0-9	tumor necrosis factor	Bos taurus	93-102
12771291-4	2003	In the myelomonocytic cell line, active vitamin D(3) is known to activate the transcription of both p21 and p27, cyclin-dependent kinase inhibitors (CDKIs), regulating the transition from the G(1) to the S phase of the cell cycle, in a VDR-dependent manner.	Vitamin D	40-49	interferon alpha inducible protein 27	Homo sapiens	108-111
12716975-0	2003	Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance.	Vitamin D	97-106	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	0-39
12716975-0	2003	Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance.	Vitamin D	97-106	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	41-46
12586749-0	2003	Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells.	Vitamin D	117-126	cyclin dependent kinase inhibitor 1B	Homo sapiens	108-112
12508107-1	2003	Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites.	Vitamin D	122-131	low density lipoprotein receptor	Homo sapiens	27-39
12508107-1	2003	Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites.	Vitamin D	171-180	low density lipoprotein receptor	Homo sapiens	27-39
12683238-4	2003	Computer analyses of DNA sequences of hpl-bp74 enabled us to identify some potential hormone responsive elements responsible for the binding of nuclear receptor for vitamin D with the DNA motifs.	Vitamin D	165-174	galectin 1	Homo sapiens	38-41
12375736-4	2002	However, the induction of osteocalcin synthesis and alkaline phosphatase activity in response to vitamin D, two characteristics of the osteoblast phenotype, were significantly antagonized by IL-1beta over a similar dose range.	Vitamin D	97-106	bone gamma-carboxyglutamate protein 2	Mus musculus	26-37
12051670-2	2002	1,25-Dihydroxyvitamin D3 supplementation, but not vitamin D supplementation, reduced the early mortality of IL-2 KO mice.	Vitamin D	14-23	interleukin 2	Mus musculus	108-112
12032488-8	2002	Vitamin D compounds are believed to increase calcium absorption by inducing a calcium channel (epithelial calcium transporter or calcium transporter-1 [CaT1]) on the luminal membrane, a calcium-binding protein (Calbindin D9k) in the cytosol, and a calcium pump (plasma membrane calcium adenosine triphosphatase-1 [PMCA1]) on the basolateral membrane.	Vitamin D	0-9	S100 calcium binding protein G	Rattus norvegicus	211-224
11967012-5	2002	In order to study the effect of calcitriol on EGFR gene transcription, a candidate vitamin D-responsive element (VDRE) was identified in the EGFR gene promoter and complimentary 30-mer oligonucleotides spanning this region were tested for binding to recombinant VDR using EMSA.	Vitamin D	83-92	vitamin D receptor	Rattus norvegicus	113-116
11880238-12	2002	The results from the current and previous studies on renal vitamin D hydroxylations imply that CYP2D25 has a biological role in kidney.	Vitamin D	59-68	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	95-102
11818502-9	2002	Taken together, these findings suggest that increased interaction between VDR and coactivators such as DRIP205 may be a major mechanism that couples extracellular signals to vitamin D action.	Vitamin D	174-183	vitamin D receptor	Rattus norvegicus	74-77
11840342-7	2002	Other important regulators of Cyr61 expression in breast cancer cells that we found are the phorbol ester TPA, vitamin D, and retinoic acid.	Vitamin D	111-120	cellular communication network factor 1	Homo sapiens	30-35
11840342-9	2002	Vitamin D induces a transient stimulatory effect on Cyr61 gene expression.	Vitamin D	0-9	cellular communication network factor 1	Homo sapiens	52-57
11785948-0	2002	Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter.	Vitamin D	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	83-88
11785948-0	2002	Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter.	Vitamin D	45-54	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	83-88
12489206-6	2002	Combining Msx2 overexpression and vitamin D addition in vitro, we showed an inhibitory effect on osteocalcin expression in immortalized MO6-G3 odontoblasts.	Vitamin D	34-43	bone gamma-carboxyglutamate protein 2	Mus musculus	97-108
12386263-12	2002	1,25-dihydroxy-22-oxavitamin D(3) (22-oxacalcitriol, OCT) is a vitamin D analogue that could control serum PTH concentrations without deleterious effects on bone.	Vitamin D	21-30	plexin A2	Homo sapiens	53-56
11679963-8	2001	Vitamin D reduced the concentration of IL-2 and IL-12 in serum and in grafts, and increased IL-4 and IL-10 in the grafts.	Vitamin D	0-9	interleukin 2	Rattus norvegicus	39-43
11679963-8	2001	Vitamin D reduced the concentration of IL-2 and IL-12 in serum and in grafts, and increased IL-4 and IL-10 in the grafts.	Vitamin D	0-9	interleukin 12B	Rattus norvegicus	48-53
11679963-8	2001	Vitamin D reduced the concentration of IL-2 and IL-12 in serum and in grafts, and increased IL-4 and IL-10 in the grafts.	Vitamin D	0-9	interleukin 10	Rattus norvegicus	101-106
11402043-1	2001	We investigated intracellular mechanisms involved in the up-regulation of plasminogen activator inhibitor I (PAI-1) synthesis by human recombinant tumor necrosis factor-alpha (TNF) during monocyte differentiation of HL-60 cells triggered by the transforming growth factor-beta1/vitamin D(3) (TGF/D3) mixture.	Vitamin D	278-287	serpin family E member 1	Homo sapiens	109-114
11479138-0	2001	Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue.	Vitamin D	18-27	leptin	Homo sapiens	59-65
11479138-8	2001	In conclusion, in vitro leptin secretion by human adipose tissue is negatively controlled by either RA or vitamin D(3).	Vitamin D	106-115	leptin	Homo sapiens	24-30
11470825-0	2001	Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.	Vitamin D	0-9	catenin beta 1	Homo sapiens	120-132
11597027-0	2001	Transforming growth factor-beta1 and basic fibroblast growth factor modulate osteocalcin and osteonectin/SPARC syntheses in vitamin-D-activated pulp cells.	Vitamin D	124-133	secreted protein acidic and cysteine rich	Homo sapiens	105-110
11302745-9	2001	Deletion of the SSA2, SSA3, and SSA4 genes and reduction of Ssa1p activity, reduces the intracellular concentrations of the VDR and its heterodimeric partner, RXRalpha and reduces the activity of a vitamin D-dependent gene.	Vitamin D	198-207	Hsp70 family chaperone SSA4	Saccharomyces cerevisiae S288C	32-36
11302745-9	2001	Deletion of the SSA2, SSA3, and SSA4 genes and reduction of Ssa1p activity, reduces the intracellular concentrations of the VDR and its heterodimeric partner, RXRalpha and reduces the activity of a vitamin D-dependent gene.	Vitamin D	198-207	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	60-65
11290607-0	2001	Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.	Vitamin D	6-15	phosphatase and tensin homolog	Homo sapiens	155-159
11179723-3	2001	The organization of the vitamin D response element (VDRE), the multiple activities of the vitamin D receptor transactivation complex, and the necessity for protein-protein interactions between the VDR-RXR heterodimer activation complex and DNA binding proteins at other regulatory elements, including AP-1 sites and TATA boxes, provide for precise regulation of gene activity in concert with basal levels of transcription.	Vitamin D	24-33	vitamin D receptor	Rattus norvegicus	52-55
10976917-7	2000	Stable overexpression of IDBP-1 in wild-type cells enhanced vitamin D-directed responsiveness of endogenous vitamin D-24-hydroxylase, osteopontin, and osteocalcin genes by several-fold over that observed in cells transfected with an empty vector.	Vitamin D	60-69	secreted phosphoprotein 1	Homo sapiens	134-145
10982952-1	2000	A case of familial hypophosphatemic vitamin D-resistant rickets or X-linked hypophosphatemia (XLH) accompanied by specific systemic and dental findings is reported.	Vitamin D	36-45	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	94-97
10875240-2	2000	Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,25-dihydroxyvitamin D3 (vitamin D, 10 nM) increased IGFBP-3 in media to 149 +/- 15% and 206 +/- 18% of control, respectively, when added separately, and to 453 +/- 28% of control when used in combination.	Vitamin D	133-142	insulin like growth factor binding protein 3	Homo sapiens	63-70
10585721-2	1999	We used rapid buffer exchange gel filtration in conjunction with microelectrospray ionization mass spectrometry (microESI-MS) to study the binding of these receptors to the osteopontin vitamin D response element (OP VDRE).	Vitamin D	185-194	secreted phosphoprotein 1	Homo sapiens	173-184
10542271-0	1999	Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements.	Vitamin D	51-60	interferon alpha inducible protein 27	Homo sapiens	71-74
10542271-0	1999	Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements.	Vitamin D	51-60	cyclin dependent kinase inhibitor 1B	Homo sapiens	75-79
10542271-2	1999	It has been reported that overexpression of the cdk inhibitor p27(Kip1) results in the differentiation of the myelomonocytic U937 cell line and that this gene is the target of vitamin D(3).	Vitamin D	176-185	interferon alpha inducible protein 27	Homo sapiens	62-65
10542271-2	1999	It has been reported that overexpression of the cdk inhibitor p27(Kip1) results in the differentiation of the myelomonocytic U937 cell line and that this gene is the target of vitamin D(3).	Vitamin D	176-185	cyclin dependent kinase inhibitor 1B	Homo sapiens	66-70
10542271-9	1999	We conclude that vitamin D(3) stimulates transcription of the p27(Kip1) gene by a novel mechanism involving Sp1 and NF-Y, but not the vitamin D receptor, during the early stages of U937 cell differentiation.	Vitamin D	17-26	interferon alpha inducible protein 27	Homo sapiens	62-65
10542271-9	1999	We conclude that vitamin D(3) stimulates transcription of the p27(Kip1) gene by a novel mechanism involving Sp1 and NF-Y, but not the vitamin D receptor, during the early stages of U937 cell differentiation.	Vitamin D	17-26	cyclin dependent kinase inhibitor 1B	Homo sapiens	66-70
10571682-0	1999	Vitamin D receptor interactions with the rat parathyroid hormone gene: synergistic effects between two negative vitamin D response elements.	Vitamin D	112-121	vitamin D receptor	Rattus norvegicus	0-18
10571682-2	1999	Gel mobility shift assays using DNA restriction enzyme fragments and recombinant proteins for vitamin D and retinoic acid X receptors (VDR/RXR) revealed a sequence between -793 and -779 that bound a VDR/RXR heterodimer with high affinity (VDRE1).	Vitamin D	94-103	vitamin D receptor	Rattus norvegicus	199-202
10505692-0	1999	Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes.	Vitamin D	24-33	lipoprotein lipase	Homo sapiens	61-79
10424766-0	1999	Establishment of permanent cell lines exhibiting vitamin D-dependent expression of beta-galactosidase activity.	Vitamin D	49-58	galactosidase, beta 1	Rattus norvegicus	83-101
10439207-5	1999	X-linked hypophosphatemic rickets, a dominantly inherited disease, is caused by mutations in the PHEX gene, whose function in regulating renal phosphate and vitamin D metabolism remains to be elucidated.	Vitamin D	157-166	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	97-101
10385391-1	1999	Prior studies have shown that 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] plays a major role in resting zone chondrocyte differentiation and that this vitamin D metabolite regulates both phospholipase A2 and protein kinase C (PKC) specific activities.	Vitamin D	45-54	phospholipase A2 group IB	Rattus norvegicus	185-201
10336890-6	1999	Despite the altered polarity, the DR5-bound heterodimer was able to recruit the nuclear receptor coactivator ACTR in a vitamin D-dependent fashion.	Vitamin D	119-128	TNF receptor superfamily member 10b	Homo sapiens	34-37
10224044-6	1999	Taken together, our results strongly suggest that the interplay between the TGF-beta and vitamin D signaling pathways is, at least in part, mediated by the two classes of Smad proteins, which modulate VDR transactivation function both positively and negatively.	Vitamin D	89-98	SMAD family member 6	Homo sapiens	171-175
10026100-0	1999	Vitamin D regulates human ectocervical epithelial cell proliferation and insulin-like growth factor-binding protein-3 level.	Vitamin D	0-9	insulin like growth factor binding protein 3	Homo sapiens	73-117
10026100-9	1999	These studies show that vitamin D regulates cervical epithelial cell gene regulation and cell proliferation and that IGFBP-3 may be an in vivo marker of vitamin D action in the cervix.	Vitamin D	153-162	insulin like growth factor binding protein 3	Homo sapiens	117-124
11056661-3	1999	Discoordinate regulation by vitamin D of MMP-1 and MMP-9 in human mononuclear phagocytes has also been reported.	Vitamin D	28-37	matrix metallopeptidase 1	Homo sapiens	41-46
10489163-0	1999	Mechanism of antimitogenic action of vitamin D in human colon carcinoma cells: relevance for suppression of epidermal growth factor-stimulated cell growth.	Vitamin D	37-46	epidermal growth factor	Homo sapiens	108-131
10489163-5	1999	The ability of 1alpha,25-(OH)2D3 to interfere with a key event in cell cycle control and thereby to block mitogenic signaling from EGF could be seen as advantageous for the potential use of vitamin D compounds in colon cancer therapy.	Vitamin D	190-199	epidermal growth factor	Homo sapiens	131-134
9815276-0	1998	In vivo dose-related receptor binding of the vitamin D analogue [3H]-1,25-dihydroxy-22-oxavitamin D3 (OCT) in rat parathyroid, kidney distal and proximal tubules, duodenum, and skin, studied by quantitative receptor autoradiography.	Vitamin D	45-54	plexin A2	Homo sapiens	102-105
9717845-8	1998	Gel shift assays showed that a purified vitamin D receptor and retinoid X receptor-beta bound to the PTH promoter"s chicken and rat vitamin D response element (VDRE), and this binding was inhibited by added pure calreticulin.	Vitamin D	40-49	parathyroid hormone	Gallus gallus	101-104
9625815-0	1998	Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089.	Vitamin D	130-139	insulin like growth factor 2	Homo sapiens	14-49
9625815-0	1998	Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089.	Vitamin D	130-139	insulin like growth factor binding protein 3	Homo sapiens	54-75
9625815-0	1998	Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089.	Vitamin D	130-139	chromobox 8	Homo sapiens	100-104
9587402-2	1998	The calbindins are a family of vitamin D-dependent calcium-binding proteins found in the intestine (calbindin D-9k) and kidney (calbindin D-28k) and are thought to play a role in calcium transport and homeostasis.	Vitamin D	31-40	S100 calcium binding protein G	Rattus norvegicus	100-114
9531195-7	1998	Target genes for 1,25(OH)2D3 including those encoding for the bone matrix proteins osteopontin (OPN) and osteocalcin (OCN), possess vitamin D response elements (VDRE) upstream of the transcriptional start site.	Vitamin D	132-141	secreted phosphoprotein 1	Homo sapiens	83-94
9531195-7	1998	Target genes for 1,25(OH)2D3 including those encoding for the bone matrix proteins osteopontin (OPN) and osteocalcin (OCN), possess vitamin D response elements (VDRE) upstream of the transcriptional start site.	Vitamin D	132-141	secreted phosphoprotein 1	Homo sapiens	96-99
9379138-7	1997	Vitamin D responsive elements (VDREs) consisting of direct hexanucleotide repeats with a spacer of three nucleotides have been identified in the promoter regions of positively controlled genes expressed in bone, such as osteocalcin, osteopontin, beta 3-integrin and vitamin D 24-OHase.	Vitamin D	0-9	secreted phosphoprotein 1	Homo sapiens	233-244
9379138-14	1997	The above events, including bridging by coactivators to the TATA binding protein and associated factors, may position VDR such that it is able to attract TFIIB and the balance of the RNA polymerase II transcription machinery, culminating in repeated transcriptional initiation of VDRE-containing, vitamin D target genes.	Vitamin D	297-306	cilia and flagella associated protein 20	Homo sapiens	154-159
9815816-0	1997	Three synthetic vitamin D analogues induce prostate-specific acid phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion.	Vitamin D	16-25	kallikrein related peptidase 3	Homo sapiens	82-107
9211349-1	1997	The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes.	Vitamin D	107-116	vitamin D receptor	Rattus norvegicus	97-100
9204985-0	1997	Interaction of vitamin D derivatives and granulocyte-macrophage colony-stimulating factor in leukaemic cell differentiation.	Vitamin D	15-24	colony stimulating factor 2	Homo sapiens	41-89
9204985-1	1997	The ability of the physiologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and two novel vitamin D analogues, EB1089 and KH1060 to induce the differentiation of the U937 and HL-60 leukaemic cell lines was evaluated, alone or in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF).	Vitamin D	50-59	colony stimulating factor 2	Homo sapiens	270-318
9204985-1	1997	The ability of the physiologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and two novel vitamin D analogues, EB1089 and KH1060 to induce the differentiation of the U937 and HL-60 leukaemic cell lines was evaluated, alone or in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF).	Vitamin D	50-59	colony stimulating factor 2	Homo sapiens	320-326
9180905-18	1997	Further, by eliminating the VDR-mediated component of the cellular response, we have provided further evidence for the existence of a membrane receptor(s) involved in mediating nongenomic effects of vitamin D metabolites.	Vitamin D	199-208	vitamin D receptor	Rattus norvegicus	28-31
9143355-1	1997	The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes.	Vitamin D	89-98	vitamin D receptor	Rattus norvegicus	134-137
9365187-6	1997	In long-term cultures, when sequentially exposed to vitamin D (days 0-21) and GMCSF (days 5-10) and plated on collagen, the amount of expression of aromatase mRNA steadily increased along with the increasing expression of osteopontin mRNA, alpha(v) integrin mRNA, c-fms (MCSF-receptor) mRNA and multinucleated cells developing.	Vitamin D	52-61	secreted phosphoprotein 1	Homo sapiens	222-233
9058197-3	1997	Because the actions of 1,25-(OH)2D3 are mediated through the vitamin D receptor (VDR), that is a DNA binding transcription factor, vitamin D regulated genes should have VDR binding sites in their regulatory regions.	Vitamin D	61-70	vitamin D receptor	Rattus norvegicus	81-84
8887033-6	1996	BMD and vitamin D were decreased in all patients whose cholinesterase (ChE) was below 0.3 delta pH.	Vitamin D	8-17	butyrylcholinesterase	Homo sapiens	55-69
8694856-6	1996	Our results suggest that the dual effect of 1,25-(OH)2D3 on hsp28 and PKC beta gene expression is due to the different sequence composition of the vitamin D response element in the promoter region as well as an accessory factor for each gene or that 1,25-(OH)2D3 increases PKC beta gene expression, which, in turn, negatively regulates the expression of the hsp28 gene or vice versa.	Vitamin D	147-156	heat shock protein family B (small) member 1	Homo sapiens	60-65
8694856-6	1996	Our results suggest that the dual effect of 1,25-(OH)2D3 on hsp28 and PKC beta gene expression is due to the different sequence composition of the vitamin D response element in the promoter region as well as an accessory factor for each gene or that 1,25-(OH)2D3 increases PKC beta gene expression, which, in turn, negatively regulates the expression of the hsp28 gene or vice versa.	Vitamin D	147-156	heat shock protein family B (small) member 1	Homo sapiens	358-363
8668154-9	1996	Thus, the present study indicates that this new VDR isoform negatively modulates the vitamin D signaling pathway, through a particular set of target genes.	Vitamin D	85-94	vitamin D receptor	Rattus norvegicus	48-51
8687373-9	1996	Newly identified vitamin D-dependent target genes include those for Ca2+/Mg(2+)-ATPase in the intestine and p21 in the myelomonocytic U937 cell line.	Vitamin D	17-26	H3 histone pseudogene 16	Homo sapiens	108-111
8619822-1	1996	The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) in the promoter region of target genes and acts as a ligand-dependent transcriptional regulator.	Vitamin D	4-13	vitamin D receptor	Rattus norvegicus	24-27
8566748-5	1996	Furthermore, we show that p21 is transcriptionally induced by 1,25-dihydroxyvitamin D3 in a VDR-dependent, but not p53-dependent, manner, and we identify a functional vitamin D response element in the p21 promoter.	Vitamin D	76-85	H3 histone pseudogene 16	Homo sapiens	26-29
8566748-5	1996	Furthermore, we show that p21 is transcriptionally induced by 1,25-dihydroxyvitamin D3 in a VDR-dependent, but not p53-dependent, manner, and we identify a functional vitamin D response element in the p21 promoter.	Vitamin D	76-85	H3 histone pseudogene 16	Homo sapiens	201-204
8706045-3	1996	We have now identified the p65 gene as a novel member of the superfamily of genes that encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid, and thyroid hormones.	Vitamin D	162-171	golgi reassembly stacking protein 1	Homo sapiens	27-30
8584029-1	1995	It is a well established fact that the calcium-binding protein, calbindin-D28k, is influenced by vitamin D in intestine and kidney.	Vitamin D	97-106	calbindin 1	Homo sapiens	64-73
7646451-5	1995	1 alpha,24(S)-Dihydroxyvitamin D2 binds strongly to the vitamin D receptor and is biologically active in growth hormone and chloramphenicol acetyltransferase reporter gene expression systems in vitro, but binds poorly to rat vitamin D-binding globulin, DBP.	Vitamin D	23-32	vitamin D receptor	Rattus norvegicus	56-74
8579895-8	1995	Recent data reveal that after binding RXR, a subsequent target for VDR in the vitamin D signal transduction cascade is basal transcription factor IIB (TFIIB).	Vitamin D	78-87	cilia and flagella associated protein 20	Homo sapiens	125-149
8579895-8	1995	Recent data reveal that after binding RXR, a subsequent target for VDR in the vitamin D signal transduction cascade is basal transcription factor IIB (TFIIB).	Vitamin D	78-87	cilia and flagella associated protein 20	Homo sapiens	151-156
7597089-6	1995	In vitamin D-deficient rats with up-regulated renal 25-hydroxyvitamin D3 1 alpha-hydroxylase activity, expression of vitamin D receptor mRNA in renal proximal convoluted tubules was also down-regulated, indicating that the down-regulation of vitamin D receptor mRNA is not the result of the enhanced production of 1 alpha, 25-dihydroxyvitamin D3.	Vitamin D	3-12	vitamin D receptor	Rattus norvegicus	117-135
7597089-6	1995	In vitamin D-deficient rats with up-regulated renal 25-hydroxyvitamin D3 1 alpha-hydroxylase activity, expression of vitamin D receptor mRNA in renal proximal convoluted tubules was also down-regulated, indicating that the down-regulation of vitamin D receptor mRNA is not the result of the enhanced production of 1 alpha, 25-dihydroxyvitamin D3.	Vitamin D	3-12	vitamin D receptor	Rattus norvegicus	242-260
7708726-3	1995	Most important, the two specific complexes formed by porcine nuclear extract with the vitamin D response elements from either the osteocalcin gene or the rat 24-hydroxylase gene are shifted to a larger complex by both an anti-vitamin D receptor antibody and an anti-RXR antibody, leaving no doubt that in vivo the nuclear accessory factor for the vitamin D receptor in the intestine is an RXR protein.	Vitamin D	86-95	vitamin D receptor	Rattus norvegicus	226-244
7708726-3	1995	Most important, the two specific complexes formed by porcine nuclear extract with the vitamin D response elements from either the osteocalcin gene or the rat 24-hydroxylase gene are shifted to a larger complex by both an anti-vitamin D receptor antibody and an anti-RXR antibody, leaving no doubt that in vivo the nuclear accessory factor for the vitamin D receptor in the intestine is an RXR protein.	Vitamin D	86-95	vitamin D receptor	Rattus norvegicus	347-365
8034312-1	1994	The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively).	Vitamin D	150-159	vitamin D receptor	Homo sapiens	207-210
8160797-8	1994	In the human kidney, the VDR is present in cells where vitamin D-inducible proteins are found; conversely it is absent from cells where vitamin D-dependent proteins are not present.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	25-28
8160797-8	1994	In the human kidney, the VDR is present in cells where vitamin D-inducible proteins are found; conversely it is absent from cells where vitamin D-dependent proteins are not present.	Vitamin D	136-145	vitamin D receptor	Homo sapiens	25-28
8015545-4	1994	However, we have previously shown that a closely related, but distinct, element (AGTTCA; essentially the mouse osteopontin [Spp-1] vitamin D response element) acts as a high affinity target for purified hVDR in the absence of RXR.	Vitamin D	131-140	vitamin D receptor	Homo sapiens	203-207
8015545-7	1994	We find that the purified receptor selects a heptameric sequence resembling a half-site of the osteopontin vitamin D response element, consistent with osteopontin-like sequences acting as high affinity targets for hVDR in the absence of RXR.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	214-218
8177979-11	1994	Vitamin D-regulated factors that are involved in vitamin D-dependent active Ca transport and are present in both renal DT and intestinal epithelial cells include VDR, CaBP-D9k/28k and the PMCA.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	162-165
8106467-3	1994	When an expression vector for the vitamin D receptor (VDR) (pSVL-VDR) was introduced together with the reporter plasmid, there was a significant ligand-dependent amplification of the vitamin D-dependent inhibition.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	54-57
8106467-3	1994	When an expression vector for the vitamin D receptor (VDR) (pSVL-VDR) was introduced together with the reporter plasmid, there was a significant ligand-dependent amplification of the vitamin D-dependent inhibition.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	65-68
8106467-8	1994	Both the SV40 promoter and a conventional vitamin D response element linked to a truncated SV40 promoter were activated by the liganded vitamin D receptor, whereas the Rous sarcoma virus promoter was unaffected.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	136-154
8286356-0	1994	DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene.	Vitamin D	76-85	deoxyribonuclease 1	Rattus norvegicus	0-7
8227160-2	1993	Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent.	Vitamin D	45-54	protein kinase C, gamma	Rattus norvegicus	104-120
8227160-2	1993	Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent.	Vitamin D	45-54	protein kinase C, gamma	Rattus norvegicus	122-125
8227160-2	1993	Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent.	Vitamin D	247-256	protein kinase C, gamma	Rattus norvegicus	104-120
8227160-2	1993	Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent.	Vitamin D	247-256	protein kinase C, gamma	Rattus norvegicus	122-125
8227160-2	1993	Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent.	Vitamin D	247-256	protein kinase C, gamma	Rattus norvegicus	236-239
8227160-11	1993	The results of this study indicate that vitamin D metabolites stimulate PKC activity in a metabolite- and cell-maturation-specific manner.	Vitamin D	40-49	protein kinase C, gamma	Rattus norvegicus	72-75
8218210-10	1993	The presence of multiple GR binding sites in the rat OC gene proximal promoter indicates that regulation of basal and vitamin D-enhanced transcription by glucocorticoids may involve the integrated activities of multiple, independent GREs.	Vitamin D	118-127	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	25-27
8274878-1	1993	We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	167-176	protein kinase C, gamma	Rattus norvegicus	22-38
8274878-1	1993	We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	167-176	protein kinase C, gamma	Rattus norvegicus	40-43
8394351-10	1993	In combination with all-trans-retinoic acid, however, vitamin D enhances VDR-RAR heterodimer-mediated gene expression.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	73-76
8392085-1	1993	We have identified and characterized two mutations in the hormone binding domain of the vitamin D receptor (VDR) in patients with hereditary vitamin D-resistant rickets.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	108-111
8505313-3	1993	The immune complex phosphatase assay using the antibody demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) and a vitamin D metabolite increased the PTP activity of immunoprecipitated PTP1C to 230 and 150% of control, respectively.	Vitamin D	123-132	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	193-198
8377726-6	1993	We conclude that PTHrP(1-34) causes similar effects on bone, in organ cultures, to those caused by bPTH(1-34), namely an increase in both bone resorption and formation and a decrease in the vitamin D-stimulated BGP synthesis.	Vitamin D	190-199	parathyroid hormone-like hormone	Rattus norvegicus	17-22
1446602-1	1992	We recently described the existence of a competitive binding component in vitamin D-resistant New World primate cells that has a relatively low affinity (Kd, approximately 10(-8) M) but high capacity for 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] compared to that possessed by the vitamin D receptor (VDR).	Vitamin D	74-83	vitamin D3 receptor	Callithrix jacchus	278-296
1446602-1	1992	We recently described the existence of a competitive binding component in vitamin D-resistant New World primate cells that has a relatively low affinity (Kd, approximately 10(-8) M) but high capacity for 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] compared to that possessed by the vitamin D receptor (VDR).	Vitamin D	74-83	vitamin D3 receptor	Callithrix jacchus	298-301
1336301-1	1992	We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	56-59
1336301-1	1992	We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	36-54
1336301-1	1992	We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	56-59
1336385-1	1992	Regulation of vitamin D-binding protein production by various hormones was studied in an established human hepatoma cell line, HuH-7.	Vitamin D	14-23	MIR7-3 host gene	Homo sapiens	127-132
1337987-10	1992	Taken together, the study demonstrates a vitamin D-induced inhibitory effect of LPS-driven monokine production, which is most likely a vitamin D-receptor mediated phenomenon exerted at a post-transcriptional, presecretory level.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	135-153
1353882-2	1992	Its synthesis is induced by calcitriol, the active hormonal form of vitamin D, through the vitamin D receptor and a specific vitamin D-responsive element in the osteocalcin gene promoter.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	91-109
1624101-1	1992	The dependency of calbindin 28K synthesis on estrogen and vitamin D and its relationship with calcium transfer were investigated in the uterus of laying hens by dot blot hybridization analysis using as a probe a cDNA coding for calbindin.	Vitamin D	58-67	calbindin 1	Gallus gallus	18-27
1374401-1	1992	Vitamin D-binding protein (DBP), a member of a multigene family including alpha-fetoprotein (AFP) and albumin, is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells.	Vitamin D	172-181	GC vitamin D binding protein	Homo sapiens	0-25
1544902-4	1992	Binding of human progesterone receptor to the PRE was also enhanced in the presence of the antiprogestin, RU486, but very little effect was observed in the presence of estradiol, dexamethasone, testosterone, and vitamin D.	Vitamin D	212-221	progesterone receptor	Gallus gallus	17-38
1581109-2	1992	Previous studies, demonstrating a correlation between 1,25-(OH)2D3-dependent alkaline phosphatase and phospholipase A2 activities in matrix vesicles isolated from growth cartilage chondrocyte cultures, suggest that one mechanism of vitamin D action may be via autocrine or paracrine action of PGE2.	Vitamin D	232-241	phospholipase A2, group IB, pancreas	Mus musculus	102-118
1543898-7	1992	Other nuclear factors such as fos and jun can influence vitamin D-mediated gene expression.	Vitamin D	56-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
1303095-1	1992	The vitamin-D-binding protein (DBP), also called group-specific component, is well known for two main reasons: its genetic polymorphism, and its binding affinities for actin and vitamin D compounds.	Vitamin D	178-187	GC vitamin D binding protein	Homo sapiens	4-29
1303095-1	1992	The vitamin-D-binding protein (DBP), also called group-specific component, is well known for two main reasons: its genetic polymorphism, and its binding affinities for actin and vitamin D compounds.	Vitamin D	178-187	GC vitamin D binding protein	Homo sapiens	31-34
1303095-3	1992	The molecular genetic data for DBP are analyzed in order to show that the affinities for vitamin D are supported by the genetic variability.	Vitamin D	89-98	GC vitamin D binding protein	Homo sapiens	31-34
1727425-1	1992	For the quantitative analysis of vitamin D-dependent 28-kDa calcium-binding protein (calbindin-D) in the CNS, we have established a highly sensitive immunoassay method.	Vitamin D	33-42	hippocalcin	Rattus norvegicus	60-83
1660470-3	1991	In this report, we examine the nature of specific VDR DNA binding utilizing the vitamin D-responsive element derived from the human osteocalcin promoter.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	50-53
1667458-0	1991	Determination of the affinity of vitamin D metabolites to serum vitamin D binding protein using assay employing lipid-coated polystyrene beads.	Vitamin D	33-42	GC vitamin D binding protein	Homo sapiens	64-89
1667458-1	1991	We have developed an assay to measure the affinity of serum vitamin D binding protein for 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, and vitamin D3, using uniform diameter (6.4 microns) polystyrene beads coated with phosphatidylcholine and vitamin D metabolites as the vitamin D donor.	Vitamin D	100-109	GC vitamin D binding protein	Homo sapiens	60-85
1667458-6	1991	All three vitamin D metabolites became bound to serum vitamin D binding protein, and after 10 min of incubation the transfer of the metabolites to serum vitamin D binding protein was time independent.	Vitamin D	10-19	GC vitamin D binding protein	Homo sapiens	54-79
1667458-6	1991	All three vitamin D metabolites became bound to serum vitamin D binding protein, and after 10 min of incubation the transfer of the metabolites to serum vitamin D binding protein was time independent.	Vitamin D	10-19	GC vitamin D binding protein	Homo sapiens	153-178
1667458-9	1991	In conclusion, we have developed a method which avoids problems encountered in previous assays and allows the precise and convenient determination of binding affinities of vitamin D metabolites and serum vitamin D binding protein.	Vitamin D	172-181	GC vitamin D binding protein	Homo sapiens	204-229
1883119-9	1991	Women treated with vitamin D had a similar spinal increase in period 1 (1.46% compared with 1.40% in placebo), less loss in period 2 (-0.54% compared with -1.22%, CI for the difference, 0.05% to 1.31%, P = 0.032) and a significant overall benefit (0.85% compared with 0.15%, CI for the difference, 0.03% to 1.37%, P = 0.04).	Vitamin D	19-28	period circadian regulator 2	Homo sapiens	124-132
1665675-5	1991	Future studies with regard to the mechanism of vitamin D action must be aimed at gaining additional insight into the nature of VDREs, acquiring further detail about the interaction of the VDR with these elements, identifying factors that facilitate VDR DNA binding, and determining the biochemical mechanism by which the binding of receptor to these elements leads to modulation of common transcriptional machinery.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	127-130
1665675-5	1991	Future studies with regard to the mechanism of vitamin D action must be aimed at gaining additional insight into the nature of VDREs, acquiring further detail about the interaction of the VDR with these elements, identifying factors that facilitate VDR DNA binding, and determining the biochemical mechanism by which the binding of receptor to these elements leads to modulation of common transcriptional machinery.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	188-191
1796753-0	1991	Vitamin D analogs with low affinity for the vitamin D binding protein: enhanced in vitro and decreased in vivo activity.	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	44-69
1757478-3	1991	We systematically evaluated MGP mRNA expression as a function of bone and cartilage development and also as regulated by vitamin D during growth and cellular differentiation.	Vitamin D	121-130	matrix Gla protein	Rattus norvegicus	28-31
1757478-12	1991	Interestingly, when MGP mRNA transcripts from vitamin D treated and untreated chondrocytes and osteoblasts were analyzed by high resolution Northern blot analysis, we observed two distinct species of MGP mRNA in the vitamin D treated chondrocyte cultures while all other cultures examined exhibited only a single MGP mRNA transcript.	Vitamin D	46-55	matrix Gla protein	Rattus norvegicus	20-23
1757478-12	1991	Interestingly, when MGP mRNA transcripts from vitamin D treated and untreated chondrocytes and osteoblasts were analyzed by high resolution Northern blot analysis, we observed two distinct species of MGP mRNA in the vitamin D treated chondrocyte cultures while all other cultures examined exhibited only a single MGP mRNA transcript.	Vitamin D	216-225	matrix Gla protein	Rattus norvegicus	200-203
1757478-12	1991	Interestingly, when MGP mRNA transcripts from vitamin D treated and untreated chondrocytes and osteoblasts were analyzed by high resolution Northern blot analysis, we observed two distinct species of MGP mRNA in the vitamin D treated chondrocyte cultures while all other cultures examined exhibited only a single MGP mRNA transcript.	Vitamin D	216-225	matrix Gla protein	Rattus norvegicus	200-203
1757478-13	1991	Primer extension analysis indicated a single transcription start site in both osteoblasts and chondrocytes with or without vitamin D treatment, suggesting that the lower molecular weight MGP message in vitamin D treated chondrocytes may be related to a modification in post-transcriptional processing.	Vitamin D	123-132	matrix Gla protein	Rattus norvegicus	187-190
1757478-13	1991	Primer extension analysis indicated a single transcription start site in both osteoblasts and chondrocytes with or without vitamin D treatment, suggesting that the lower molecular weight MGP message in vitamin D treated chondrocytes may be related to a modification in post-transcriptional processing.	Vitamin D	202-211	matrix Gla protein	Rattus norvegicus	187-190
2036965-1	1991	The mouse kidney is a unique tissue since both vitamin D-dependent calcium binding proteins (calbindin-D9k and calbindin-D28k) are present in the same cells of the distal convoluted tubule.	Vitamin D	47-56	calbindin 1	Mus musculus	111-125
2036965-5	1991	The peak of induction of renal calbindin-D28k mRNA was at 12 h after a single injection of 1,25(OH)2D3 (200 ng/100 g body wt) to vitamin D-deficient mice, and a decrease was observed at 24 h (similar to the time course of response of other steroid-regulated genes).	Vitamin D	129-138	calbindin 1	Mus musculus	31-45
1850510-1	1991	The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes which encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid and thyroid hormones.	Vitamin D	169-178	thyroid hormone receptor alpha	Homo sapiens	4-34
1850510-1	1991	The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes which encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid and thyroid hormones.	Vitamin D	169-178	thyroid hormone receptor alpha	Homo sapiens	36-40
1850510-1	1991	The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes which encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid and thyroid hormones.	Vitamin D	169-178	thyroid hormone receptor alpha	Homo sapiens	44-52
2174892-6	1990	Binding, however, required the presence of a mammalian cell protein factor that also enhances vitamin D response element interaction by mammalian cell-derived VDR.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	159-162
2171704-3	1990	Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	70-73
2171704-3	1990	Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	93-96
2171704-9	1990	These results indicate that a decreased concentration of VDR secondary to persistent hypophosphatemia is one of the causes of vitamin D resistance in XLH.	Vitamin D	126-135	vitamin D receptor	Homo sapiens	57-60
1696927-1	1990	The group-specific component (GC), also known as the vitamin D-binding protein, transports vitamin D and its metabolites in plasma to target tissues throughout the body.	Vitamin D	53-62	vitamin D binding protein	Mus musculus	4-33
2177015-3	1990	Intestinal calbindin and its mRNA were almost absent in vitamin D-deficient chicks and were not affected by dietary alteration.	Vitamin D	56-65	calbindin 1	Gallus gallus	11-20
2177015-4	1990	Renal calbindin and its mRNA were lower in the vitamin D-deficient than in vitamin D3- or 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-fed chicks.	Vitamin D	47-56	calbindin 1	Gallus gallus	6-15
2177015-9	1990	The results suggest that: (a) most of the changes in renal and intestinal calbindin could be attributed to the changes in the mRNA; (b) the adaptation to dietary Ca and P alterations requires vitamin D metabolites; (c) high dietary Ca affects intestinal and renal calbindin-mRNA and calbindin via mechanisms independent of kidney 1-hydroxylase; and (d) plasma Ca and renal calbindin or its mRNA tend to change together in vitamin D-deficient or vitamin D3-fed, but not in 1,25(OH)2D3-fed chicks.	Vitamin D	192-201	calbindin 1	Gallus gallus	74-83
2177015-9	1990	The results suggest that: (a) most of the changes in renal and intestinal calbindin could be attributed to the changes in the mRNA; (b) the adaptation to dietary Ca and P alterations requires vitamin D metabolites; (c) high dietary Ca affects intestinal and renal calbindin-mRNA and calbindin via mechanisms independent of kidney 1-hydroxylase; and (d) plasma Ca and renal calbindin or its mRNA tend to change together in vitamin D-deficient or vitamin D3-fed, but not in 1,25(OH)2D3-fed chicks.	Vitamin D	422-431	calbindin 1	Gallus gallus	74-83
2168795-2	1990	The results showed that vitamin D deficiency rickets (VDR) were still present in some infants when vitamin D was sufficient, because of deficiency of 1,25-dihydroxyvitamin D (1,25-(OH)2D3).	Vitamin D	24-33	vitamin D receptor	Homo sapiens	54-57
2168795-2	1990	The results showed that vitamin D deficiency rickets (VDR) were still present in some infants when vitamin D was sufficient, because of deficiency of 1,25-dihydroxyvitamin D (1,25-(OH)2D3).	Vitamin D	99-108	vitamin D receptor	Homo sapiens	54-57
33771629-6	2021	infection and whether this cytokine and IL-15 can increase P. brasiliensis control in a vitamin D dependent manner.	Vitamin D	88-97	interleukin 15	Homo sapiens	40-45
33771629-14	2021	Together, data showed that IL-32 is present in lesions of PCM, PbAg induces IL-32, and the axis of IL-15/IL-32/vitamin D can contribute to control fungal infection.	Vitamin D	111-120	interleukin 15	Homo sapiens	99-104
33771629-16	2021	This is the first description about IL-15/IL-32/vitamin D pathway role in P. brasiliensis infection.	Vitamin D	48-57	interleukin 15	Homo sapiens	36-41
33819632-2	2021	It has been proposed that the ability of vitamin D to exert anti-inflammatory effects might not depend solely on the concentration of serum 25(OH)D but also on the concentration of vitamin D-binding protein (DBP).	Vitamin D	41-50	GC vitamin D binding protein	Homo sapiens	181-206
34942358-0	2022	Vitamin D mitigates diabetes-associated metabolic and cognitive dysfunction by modulating gut microbiota and colonic cannabinoid receptor 1.	Vitamin D	0-9	cannabinoid receptor 1	Rattus norvegicus	117-139
34958913-4	2022	METHODS: Experiments were carried out in mice receiving vitamin D (Vit D) to induce valvular calcification.	Vitamin D	56-65	vitrin	Mus musculus	67-70
34655755-2	2022	Vitamin D can affect the differentiation, maturation, and activation of dendritic cells (DCs) and regulate autophagy via vitamin D receptor signaling.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	121-139
34687115-5	2022	The correlation between vitamin D levels and fasting glucose (FG), fasting insulin (FI), Homeostatic model assessment of insulin resistance (HOMA-IR) index, area under glucose curve (AUC-Glyc) and area under insulin curve (AUC-Ins), was evaluated.	Vitamin D	24-33	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	53-60
34727512-8	2022	Following vitamin D therapy there were 148 (77.9%) VDR and 42 (22.1%) VDNR.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	51-54
34534708-4	2022	To reach the correct diagnosis, clinicians must recognize the typical clinical manifestations of intravenous iron-induced hypophosphatemia and identify a specific pattern of biochemical changes (hyperphosphaturic hypophosphatemia triggered by high FGF23 that causes low 1,25 (OH)2 vitamin D, hypocalcemia and secondary hyperparathyroidism).	Vitamin D	281-290	fibroblast growth factor 23	Homo sapiens	248-253
34743945-4	2021	Vitamin D interaction with the vitamin D receptor (VDR), which has transcriptional imparts and is displayed on a variety of cell types, including those of the immune system, appears to be accountable for the immune-modulating effects.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	31-49
34743945-4	2021	Vitamin D interaction with the vitamin D receptor (VDR), which has transcriptional imparts and is displayed on a variety of cell types, including those of the immune system, appears to be accountable for the immune-modulating effects.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	51-54
34710370-7	2021	In silico results identified the presence of vitamin D response element (VDRE) sequence on PRMT1 suggesting that VDR could regulate PRMT1 gene expression.	Vitamin D	45-54	protein arginine methyltransferase 1	Homo sapiens	91-96
34710370-7	2021	In silico results identified the presence of vitamin D response element (VDRE) sequence on PRMT1 suggesting that VDR could regulate PRMT1 gene expression.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	113-116
34710370-7	2021	In silico results identified the presence of vitamin D response element (VDRE) sequence on PRMT1 suggesting that VDR could regulate PRMT1 gene expression.	Vitamin D	45-54	protein arginine methyltransferase 1	Homo sapiens	132-137
34862826-2	2022	A previous study has shown that low serum Vitamin D levels were associated with food allergy, particularly amongst infants with specific VDBP gene polymorphisms (2).	Vitamin D	42-51	GC vitamin D binding protein	Homo sapiens	137-141
34917354-2	2022	Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-beta signaling pathway.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	0-18
34917354-2	2022	Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-beta signaling pathway.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	20-23
34925313-3	2021	Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR).	Vitamin D	12-21	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	55-62
34925313-3	2021	Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	64-67
34725922-2	2021	However, whether vitamin D deficiency would result in some impacts on the vitamin D binding receptor (VDR) remains to be characterized in AD.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	74-100
34725922-2	2021	However, whether vitamin D deficiency would result in some impacts on the vitamin D binding receptor (VDR) remains to be characterized in AD.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	102-105
34725922-3	2021	Vitamin D helps maintain adult brain health genomically through binding with and activating a VDR/retinoid X receptor (RXR) transcriptional complex.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	94-117
34725922-3	2021	Vitamin D helps maintain adult brain health genomically through binding with and activating a VDR/retinoid X receptor (RXR) transcriptional complex.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	119-122
34725922-7	2021	Mechanistic investigation revealed that Abeta upregulated VDR without its canonical ligand vitamin D and switched its heterodimer binding-partner from RXR to p53.	Vitamin D	91-100	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-61
34852423-9	2021	SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses.	Vitamin D	170-179	phosphodiesterase 3B	Homo sapiens	101-121
34852423-9	2021	SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses.	Vitamin D	170-179	phosphodiesterase 3B	Homo sapiens	123-128
34852423-11	2021	eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles.	Vitamin D	54-63	NAD synthetase 1	Homo sapiens	86-123
34852423-11	2021	eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles.	Vitamin D	54-63	NAD synthetase 1	Homo sapiens	125-132
34852423-11	2021	eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles.	Vitamin D	54-63	7-dehydrocholesterol reductase	Homo sapiens	138-168
34852423-11	2021	eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles.	Vitamin D	54-63	7-dehydrocholesterol reductase	Homo sapiens	170-175
34852423-12	2021	Conclusion: The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes.	Vitamin D	43-52	phosphodiesterase 3B	Homo sapiens	107-112
34852423-12	2021	Conclusion: The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes.	Vitamin D	43-52	NAD synthetase 1	Homo sapiens	114-121
34930854-1	2021	INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland.	Vitamin D	113-122	fibroblast growth factor 23	Homo sapiens	14-41
34930854-1	2021	INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland.	Vitamin D	113-122	fibroblast growth factor 23	Homo sapiens	43-48
34768025-0	2021	Maternal vitamin D deficiency reduces docosahexaenoic acid, placental growth factor and peroxisome proliferator activated receptor gamma levels in the pup brain in a rat model of preeclampsia.	Vitamin D	9-18	placental growth factor	Rattus norvegicus	60-83
34768025-0	2021	Maternal vitamin D deficiency reduces docosahexaenoic acid, placental growth factor and peroxisome proliferator activated receptor gamma levels in the pup brain in a rat model of preeclampsia.	Vitamin D	9-18	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	88-136
34412081-9	2021	CONCLUSIONS: Our findings identity CYP24A1-rs6013897 as a potential biomarker for attempted suicide and indicate that a genetic predisposition to lower vitamin D levels may contribute to attempted suicide.	Vitamin D	152-161	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	35-42
34884710-0	2021	The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis.	Vitamin D	15-24	ST2	Homo sapiens	69-72
34884710-8	2021	Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent.	Vitamin D	27-36	ST2	Homo sapiens	64-67
34884710-8	2021	Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	72-75
34727991-3	2021	This study will aim to investigate the possible effects of individual polymorphisms in vitamin D receptor (VDR) as well as effects of VDR haplotypes on response to vitamin D supplementation in breast cancer survivors.	Vitamin D	164-173	vitamin D receptor	Homo sapiens	134-137
34255195-7	2021	Furthermore, the diagnostic sensitivity of FGF23-related hypophosphatemia with vitamin D deficiency remained at 100%.	Vitamin D	79-88	fibroblast growth factor 23	Homo sapiens	43-48
34450383-0	2021	Vitamin D suppressed gastric cancer cell growth through downregulating CD44 expression in vitro and in vivo.	Vitamin D	0-9	CD44 molecule (Indian blood group)	Homo sapiens	71-75
34450383-14	2021	RESULTS: The results showed that the active form of vitamin D, 1,25(OH)2D3, had a remarkable inhibitory effect in CD44-expressing human GC MKN45 and KATO III cells, but not in CD44-null MKN28 cells.	Vitamin D	52-61	CD44 molecule (Indian blood group)	Homo sapiens	114-118
34450383-18	2021	In an orthotopic GC nude mice model, both oral intake of vitamin D and intraperitoneal injection with 1,25(OH)2D3 could significantly inhibit orthotopic GC growth and CD44 expression in vivo.	Vitamin D	57-66	CD44 antigen	Mus musculus	167-171
34273568-14	2021	The three genes are associated with inflammation control and arthritis, and SSH2 and NLRP1are also related to vitamin D modulation.	Vitamin D	110-119	slingshot protein phosphatase 2	Homo sapiens	76-80
34174792-8	2021	CRP,TNF-?, IL-6 and IL-10 levels were also correlated with serum vitamin D levels (p <0.05).	Vitamin D	65-74	interleukin 10	Homo sapiens	20-25
34616834-1	2021	This study provides novel insights into mechanisms of traffic-related air pollution-induced allergy by down-regulation via complement regulators (CFI, PROS1 and PLG) and its interaction with vitamin D deficiency via the complement inhibitor PLG https://bit.ly/3x0jYOw.	Vitamin D	191-200	complement factor I	Homo sapiens	146-149
34562448-2	2021	This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	57-75
34562448-2	2021	This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	77-80
34562448-2	2021	This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters.	Vitamin D	23-32	retinoid X receptor alpha	Homo sapiens	103-106
34562448-2	2021	This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters.	Vitamin D	167-176	vitamin D receptor	Homo sapiens	57-75
34562448-2	2021	This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters.	Vitamin D	167-176	vitamin D receptor	Homo sapiens	77-80
34562448-2	2021	This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters.	Vitamin D	167-176	retinoid X receptor alpha	Homo sapiens	103-106
34562448-11	2021	Our findings (a) identify VDR as a novel regulator of HBV-core promoter activity, (b) explain at least in part the correlation of vitamin D levels to HBV activity in clinical studies, (c) have implications on the potential use of vitamin D along with anti-HBV therapies, and (d) lay the groundwork for studies on vitamin D-mediated regulation of viruses through VDREs in virus promoters.	Vitamin D	313-322	vitamin D receptor	Homo sapiens	26-29
34087410-3	2021	Calcitriol (1,25-dihydroxyvitamin D3) and retinoic acid possess hormone-like properties and are the bioactive metabolites of vitamin D and A, respectively, that signal through heterodimers containing the common retinoid X receptor.	Vitamin D	125-134	retinoid X receptor alpha	Homo sapiens	211-230
34603404-0	2021	Corrigendum: Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study.	Vitamin D	37-46	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	68-75
34365149-9	2021	NDEVs results will need to be validated in ampler cohort but we can speculate that, if at neuronal level the amounts of Vitamin D and of VDR are comparable, than the bioavailability of vitamin D and the efficacy of the vitamin D/VDR axis is differentially modulated in PD by VDR SNPs.	Vitamin D	120-129	vitamin D receptor	Homo sapiens	275-278
34365149-9	2021	NDEVs results will need to be validated in ampler cohort but we can speculate that, if at neuronal level the amounts of Vitamin D and of VDR are comparable, than the bioavailability of vitamin D and the efficacy of the vitamin D/VDR axis is differentially modulated in PD by VDR SNPs.	Vitamin D	185-194	vitamin D receptor	Homo sapiens	275-278
34509882-9	2021	Most significantly, vitamin D fortified diet increased percent survival in KO animals and decreased the level of microglia marker IBA-1 and mTOR (mammalian target of rapamycin) downstream targets pS6 and pAKT.	Vitamin D	20-29	taste 2 receptor member 63 pseudogene	Homo sapiens	196-199
34502510-3	2021	The present study was aimed at investigating-through high-throughput gene and protein analysis-the response of human disc cells to vitamin D, depending on the VDR FokI variants.	Vitamin D	131-140	vitamin D receptor	Homo sapiens	159-162
34578986-9	2021	Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies.	Vitamin D	243-252	vitamin D receptor	Homo sapiens	26-29
34578986-9	2021	Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies.	Vitamin D	243-252	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	35-42
34261187-2	2021	Vitamin D through binding to vitamin D receptor (VDR) exerts its function and affects gene transcription in target tissues.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	29-47
34261187-2	2021	Vitamin D through binding to vitamin D receptor (VDR) exerts its function and affects gene transcription in target tissues.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	49-52
34463798-1	2022	OBJECTIVES: To explore the association between genetic polymorphisms in vitamin D receptor (VDR), vitamin D serum levels, and variability in dental age.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	72-90
34461991-1	2021	BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.	Vitamin D	91-100	surfactant protein D	Homo sapiens	157-161
34461991-1	2021	BACKGROUND: This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-alpha, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.	Vitamin D	91-100	surfactant protein D	Homo sapiens	172-176
34102194-0	2021	Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10alpha, TGF-beta and NRF-1 crosstalk.	Vitamin D	0-9	Wnt family member 10A	Rattus norvegicus	114-125
34102194-0	2021	Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10alpha, TGF-beta and NRF-1 crosstalk.	Vitamin D	0-9	transforming growth factor alpha	Rattus norvegicus	127-135
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Vitamin D	14-23	Wnt family member 10A	Rattus norvegicus	109-120
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Vitamin D	14-23	transforming growth factor alpha	Rattus norvegicus	146-154
34353392-0	2022	Long-term vitamin D and high-dose n-3 fatty acids" supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD - Expression of concern.	Vitamin D	10-19	choline dehydrogenase	Homo sapiens	140-143
34414198-0	2021	Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model.	Vitamin D	11-20	haptoglobin	Mus musculus	75-82
34346986-5	2021	In participants with the estimated glomerular filtration rate >45mL/minute/1.73m2, mean fibroblast growth factor 23 level was higher in those with 25(OH) vitamin D <20ng/mL than in those with 25(OH) vitamin D >=20ng/mL (75.6RU/mL+-42.8 versus 68.5RU/mL+-41.7; p<0.001).	Vitamin D	154-163	fibroblast growth factor 23	Homo sapiens	88-115
34346986-5	2021	In participants with the estimated glomerular filtration rate >45mL/minute/1.73m2, mean fibroblast growth factor 23 level was higher in those with 25(OH) vitamin D <20ng/mL than in those with 25(OH) vitamin D >=20ng/mL (75.6RU/mL+-42.8 versus 68.5RU/mL+-41.7; p<0.001).	Vitamin D	199-208	fibroblast growth factor 23	Homo sapiens	88-115
34408754-0	2021	Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.	Vitamin D	0-9	interleukin 22	Homo sapiens	19-24
34408754-0	2021	Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.	Vitamin D	0-9	interleukin 22	Homo sapiens	91-95
34408754-0	2021	Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.	Vitamin D	57-66	interleukin 22	Homo sapiens	19-24
34408754-0	2021	Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.	Vitamin D	57-66	interleukin 22	Homo sapiens	91-95
34408754-9	2021	Finally, we identified a vitamin D response element (VDRE) in the il22 promoter and demonstrate that 1,25(OH)2D3-VDR directly inhibits IL-22 production via this repressive VDRE.	Vitamin D	25-34	interleukin 22	Homo sapiens	66-70
34408754-9	2021	Finally, we identified a vitamin D response element (VDRE) in the il22 promoter and demonstrate that 1,25(OH)2D3-VDR directly inhibits IL-22 production via this repressive VDRE.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	113-116
34408754-9	2021	Finally, we identified a vitamin D response element (VDRE) in the il22 promoter and demonstrate that 1,25(OH)2D3-VDR directly inhibits IL-22 production via this repressive VDRE.	Vitamin D	25-34	interleukin 22	Homo sapiens	135-140
34117551-2	2021	This study aimed to investigate whether the threshold level of 25(OH)D for the diagnosis of vitamin D deficiency (VDD) in obese adolescents was lower than that in controls and to compare 25(OH)DT, free (25(OH)DF) and bioavailable (25(OH)DB) vitamin D with VDBP levels in obese individuals and their controls.	Vitamin D	92-101	GC vitamin D binding protein	Homo sapiens	256-260
34298730-6	2021	We provide evidence from both clinical studies as well as molecular studies of metabolic targets, including vitamin D receptor and activating enzymes exerting an effect on PTC tissue, which indicate that vitamin D may play a significant prognostic role in PTC.	Vitamin D	204-213	vitamin D receptor	Homo sapiens	108-126
34225707-2	2021	In this study, we quantified Vitamin D Binding Protein (VitDBP) levels in saliva as a measure of Vitamin D during orthodontic tooth movement.	Vitamin D	97-106	GC vitamin D binding protein	Homo sapiens	29-54
34225707-2	2021	In this study, we quantified Vitamin D Binding Protein (VitDBP) levels in saliva as a measure of Vitamin D during orthodontic tooth movement.	Vitamin D	97-106	GC vitamin D binding protein	Homo sapiens	56-62
34281061-12	2021	The results also demonstrated a statistically significant positive correlation between vitamin D levels and NEUTH (%), NEUTH (tys/microL), and EOS (tys/microL).	Vitamin D	87-96	EOS	Homo sapiens	143-146
34621381-0	2021	25-OH Vitamin D blood serum linkage with VDR gene polymorphism (rs2228570) in thyroid pathology patients in the West-Ukrainian population.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	41-44
34621381-4	2021	The study"s objective was to investigate the association between VDR gene polymorphism (rs2228570) with blood serum levels of 25-OH vitamin D in patients with thyroid pathology from western Ukraine.	Vitamin D	132-141	vitamin D receptor	Homo sapiens	65-68
34234589-1	2021	Background: Vitamin D deficiency (VDD) and insufficiency (VDI) is a public health problem worldwide.	Vitamin D	12-21	VDI	Homo sapiens	58-61
34166428-3	2021	Vitamin D regulates immune responses through the vitamin D receptor on CD4 cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	49-67
34239695-9	2021	The patients from the vitamin D sufficient cluster also had a significantly higher level of vitamin D/MPO, vitamin D/XO, vitamin D/MDA, vitamin D/CAT, and vitamin D/TRC than that in the vitamin deficient and insufficient clusters.	Vitamin D	22-31	tRNA-Cys (GCA) 24-1	Homo sapiens	165-168
34239695-10	2021	The vitamin D deficient cluster included significantly younger patients and had a significantly lower level of AOPP/TRC and albumin/TRC than the vitamin D sufficient cluster.	Vitamin D	4-13	tRNA-Cys (GCA) 24-1	Homo sapiens	116-119
34239695-10	2021	The vitamin D deficient cluster included significantly younger patients and had a significantly lower level of AOPP/TRC and albumin/TRC than the vitamin D sufficient cluster.	Vitamin D	4-13	tRNA-Cys (GCA) 24-1	Homo sapiens	132-135
34208589-8	2021	It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	131-149
34208589-8	2021	It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	151-154
34208603-4	2021	Therefore, this study aimed to evaluate the association of VDR polymorphisms with susceptibility to psoriasis, effectiveness of NB-UVB phototherapy and concentration of proinflammatory cytokines and vitamin D amongst the Polish population.	Vitamin D	199-208	vitamin D receptor	Homo sapiens	59-62
34221502-11	2021	After adjusting for possible confounders, not having knowledge about vitamin D foods, taking fewer vitamin D foods, and higher levels of IF-gamma and IL-10 were associated with a higher risk of having vitamin D deficiency.	Vitamin D	201-210	interleukin 10	Homo sapiens	150-155
34589658-0	2021	Very Low Vitamin D in a Patient With a Novel Pathogenic Variant in the GC Gene That Encodes Vitamin D-Binding Protein.	Vitamin D	9-18	GC vitamin D binding protein	Homo sapiens	92-117
34589658-1	2021	Circulating plasma vitamin D metabolites are highly bound to vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin.	Vitamin D	19-28	GC vitamin D binding protein	Homo sapiens	61-86
34589658-1	2021	Circulating plasma vitamin D metabolites are highly bound to vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin.	Vitamin D	19-28	GC vitamin D binding protein	Homo sapiens	136-147
34286168-1	2021	Purpose: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23).	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	179-206
34286168-1	2021	Purpose: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23).	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	208-213
34245553-5	2021	METHODS: In this study, four common VDR polymorphisms and associations with vitamin D deficiency in the Turkish Cypriot population between ages 18-40 and working in office conditions was studied by PCR- RFLP analysis.	Vitamin D	76-85	vitamin D receptor	Homo sapiens	36-39
34245553-7	2021	CONCLUSION: Together with the effect of rs2228570 C>T variant in the VDR gene, it is thought that the lifestyle changes in the Turkish Cypriot population might have caused the increased frequency of vitamin D deficiency in the young professionals.	Vitamin D	199-208	vitamin D receptor	Homo sapiens	69-72
35501225-3	2022	AIM OF THE STUDY: To evaluate the relationship between VDR gene polymorphisms FokI and BsmI with BCF and vitamin D status in a population of non-obese Mexican adults.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	55-58
35620310-5	2022	Recently, the interactions between vitamin D and BDNF have been investigated in diabetic rats.	Vitamin D	35-44	brain-derived neurotrophic factor	Rattus norvegicus	49-53
35620310-7	2022	Thus, the aim of the present study was to assess the alterations in serum BDNF and vitamin D levels in T2DM patients in Jordan, prior to and following vitamin D supplementation.	Vitamin D	151-160	brain derived neurotrophic factor	Homo sapiens	74-78
35620310-8	2022	A combination of non-experimental case-control and experimental designed studies were utilized to assess the relationship between serum BDNF and vitamin D levels in T2DM patients.	Vitamin D	145-154	brain derived neurotrophic factor	Homo sapiens	136-140
35131190-0	2022	Vitamin D status in Dupuytren"s disease: Association with clinical status and vitamin D receptor expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	78-96
35131190-11	2022	Moreover, a positive correlation was found between vitamin D levels and expression of VDR in pathologic fascia in patients undergoing fasciectomy for contracture.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	86-89
35131190-13	2022	Expression of VDR was lower in the vitamin D deficient group.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	14-17
35131190-15	2022	The potential role of vitamin D and its interaction with VDR and the TGF-beta1 signaling pathway in the pathogenesis of DD needs to be explored further.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	57-60
35510872-1	2022	Vitamin D (VD) exerts a wide variety of actions via gene regulation mediated by the nuclear vitamin D receptor (VDR) under physiological and pathological settings.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	92-110
35510872-1	2022	Vitamin D (VD) exerts a wide variety of actions via gene regulation mediated by the nuclear vitamin D receptor (VDR) under physiological and pathological settings.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	112-115
35619053-0	2022	Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice.	Vitamin D	11-20	Sp7 transcription factor 7	Mus musculus	108-115
35619053-6	2022	Early life vitamin D deficiency is associated with altered methylation of osterix and Runx2 in these bones.	Vitamin D	11-20	Sp7 transcription factor 7	Mus musculus	74-81
35590401-0	2022	Correction: Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia.	Vitamin D	12-21	fructose-bisphosphatase 1	Homo sapiens	32-36
35631254-2	2022	This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR).	Vitamin D	51-60	vitamin D receptor	Homo sapiens	176-194
35631254-2	2022	This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR).	Vitamin D	51-60	vitamin D receptor	Homo sapiens	196-199
35631254-4	2022	In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	128-131
35631254-4	2022	In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice.	Vitamin D	261-270	vitamin D receptor	Homo sapiens	128-131
35620386-10	2022	Interestingly, the PVH neurons of both sexes were activated by exogenous vitamin D (1,25-dihydroxyvitamin D3), an effect dependent upon the VDR.	Vitamin D	73-82	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	140-143
35370605-0	2022	Mediation Effects of IL-1beta and IL-18 on the Association Between Vitamin D Levels and Mild Cognitive Impairment Among Chinese Older Adults: A Case-Control Study in Taiyuan, China.	Vitamin D	67-76	interleukin 18	Homo sapiens	34-39
35308505-3	2022	The impact of vitamin D receptor (VDR) and adrenergic receptors (ADRs) genetic variants on vitamin D levels and weight loss diet outcomes was also investigated.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	14-32
35308505-13	2022	Also, the results of the present study indicate that VDR and ADRs genetic polymorphisms seem to influence vitamin D supplementation response and obesity markers.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	53-56
35001797-2	2022	Vitamin D exerts its effect through vitamin receptor (VDR), and various single nucleotide polymorphisms have been reported to affects the expression and structure of the VDR.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	54-57
35001797-2	2022	Vitamin D exerts its effect through vitamin receptor (VDR), and various single nucleotide polymorphisms have been reported to affects the expression and structure of the VDR.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	170-173
35001797-5	2022	Genetic variants in the VDR (FokI, TaqI, BsmI, and ApaI) were genotyped by TaqMan assay.Results: Reduced serum Vitamin D level was observed in subjects with sepsis compared to healthy controls (p <= 0.0001).	Vitamin D	111-120	vitamin D receptor	Homo sapiens	24-27
35084563-1	2022	Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH).	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	0-27
35084563-1	2022	Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH).	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	29-34
35267984-3	2022	This study aimed to evaluate the association of four variants in the VDR gene (rs7975232, rs1544410, rs731236, and rs2228570) with T1DM risk and vitamin D levels within a population from North Region, Brazil, as well as the influence of genomic ancestry on T1DM.	Vitamin D	145-154	vitamin D receptor	Homo sapiens	69-72
35188037-2	2022	This study was aimed to investigate the effect of the vitamin D-binding protein (VDBP) rs7041 genotype, which has a significant effect on vitamin D metabolism and PTL.	Vitamin D	138-147	GC vitamin D binding protein	Homo sapiens	54-79
35188037-2	2022	This study was aimed to investigate the effect of the vitamin D-binding protein (VDBP) rs7041 genotype, which has a significant effect on vitamin D metabolism and PTL.	Vitamin D	138-147	GC vitamin D binding protein	Homo sapiens	81-85
34779388-2	2022	We compared the association of BP in diabetic patients with either total vitamin D - the standard way of analyzing the vitamin D status - or free vitamin D, because only free vitamin D passes the cell membrane and interacts with the nuclear vitamin D receptor (VDR).	Vitamin D	175-184	vitamin D receptor	Homo sapiens	241-259
34779388-2	2022	We compared the association of BP in diabetic patients with either total vitamin D - the standard way of analyzing the vitamin D status - or free vitamin D, because only free vitamin D passes the cell membrane and interacts with the nuclear vitamin D receptor (VDR).	Vitamin D	175-184	vitamin D receptor	Homo sapiens	261-264
34981556-6	2022	And the combined results indicated vitamin D supplementation significantly reduced the level of thyroid peroxidase antibodies (TPO-Ab) compared to the control group (WMD = -158.18, 95% CI: -301.92, -14.45, p = 0.031; I2  = 68.8%, pheterogeneity  = 0.007).	Vitamin D	35-44	thyroid peroxidase	Homo sapiens	96-114
35100585-1	2022	INTRODUCTION: Vitamin D binding protein (VDBP) is correlated with non-alcoholic fatty liver disease (NAFLD) through the biological functions of regulating plasma vitamin D (VD) level and the inflammatory process.	Vitamin D	162-171	GC vitamin D binding protein	Homo sapiens	14-39
35100585-1	2022	INTRODUCTION: Vitamin D binding protein (VDBP) is correlated with non-alcoholic fatty liver disease (NAFLD) through the biological functions of regulating plasma vitamin D (VD) level and the inflammatory process.	Vitamin D	162-171	GC vitamin D binding protein	Homo sapiens	41-45
35379049-1	2022	Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer.	Vitamin D	114-123	vitamin D receptor	Homo sapiens	64-82
35379049-1	2022	Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer.	Vitamin D	153-162	vitamin D receptor	Homo sapiens	64-82
35379049-10	2022	Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	4-22
2460662-9	1988	This work demonstrates, for the first time, that epitopes of vitamin D-inducible 28kDa-CaBp and human erythrocyte Ca++-Mg++ ATPase pump are present in the same cells of the human kidney.	Vitamin D	61-70	carbonic anhydrase 1	Homo sapiens	87-91
3346251-4	1988	Calbindin mRNA in intestine and kidney is vitamin D-dependent.	Vitamin D	42-51	calbindin 1	Gallus gallus	0-9
3346251-5	1988	The maximum concentration of calbindin and its mRNA found after dosing vitamin D-deficient chicks with dihydroxyvitamin D3 (1,25-(OH)2D3) is less than 5% of that found with vitamin D dosing.	Vitamin D	71-80	calbindin 1	Gallus gallus	29-38
3346251-5	1988	The maximum concentration of calbindin and its mRNA found after dosing vitamin D-deficient chicks with dihydroxyvitamin D3 (1,25-(OH)2D3) is less than 5% of that found with vitamin D dosing.	Vitamin D	112-121	calbindin 1	Gallus gallus	29-38
2897057-1	1988	We have studied the role of vitamin D in the regulation of gastrin and gastric somatostatin secretion from the isolated perfused rat stomach.	Vitamin D	28-37	gastrin	Rattus norvegicus	59-66
2897057-5	1988	Thus, the gastrin and gastric somatostatin secretion from the Ca-deficient vitamin D-deficient rats were impaired.	Vitamin D	75-84	gastrin	Rattus norvegicus	10-17
2897057-6	1988	In addition, the impaired gastrin and gastric somatostatin secretions seem to be caused not only by a decrease in serum Ca but also by the reduced effect of the vitamin D on the G and gastric D cells.	Vitamin D	161-170	gastrin	Rattus norvegicus	26-33
3442659-3	1987	To evaluate vitamin D regulation of gene transcription, a CaBP-28 cDNA (767 base pairs) was isolated from a chicken intestine lambda gt11 library utilizing a polyvalent CaBP-28 antibody as a probe.	Vitamin D	12-21	calbindin 1	Gallus gallus	58-65
3552627-1	1987	Vitamin D binding protein (DBP), a Mr 56,000-58,000 alpha 2-glycoprotein, is the major serum protein involved in the transport of vitamin D sterols.	Vitamin D	130-139	GC vitamin D binding protein	Homo sapiens	0-25
3829120-1	1987	The molecular cloning of a cDNA fragment synthesised from rat duodenal mRNA coding for cholecalcin (calbindin), a 9000 Mr vitamin D-induced calcium-binding protein (CaBP), has been previously described.	Vitamin D	122-131	hippocalcin	Rattus norvegicus	140-163
3829120-1	1987	The molecular cloning of a cDNA fragment synthesised from rat duodenal mRNA coding for cholecalcin (calbindin), a 9000 Mr vitamin D-induced calcium-binding protein (CaBP), has been previously described.	Vitamin D	122-131	hippocalcin	Rattus norvegicus	165-169
4083341-0	1985	Effects of parathyroid hormone on puppies during development of Ca and vitamin D deficiency.	Vitamin D	71-80	parathyroid hormone	Canis lupus familiaris	11-30
3840345-8	1985	The data indicate that the most significant effect of vitamin D on kidney proteins is increased synthesis of the Mr 28,000 CaBP, suggesting that a major role of vitamin D in renal function is regulation of calcium transport at the distal tubule.	Vitamin D	54-63	hippocalcin	Rattus norvegicus	123-127
3840345-8	1985	The data indicate that the most significant effect of vitamin D on kidney proteins is increased synthesis of the Mr 28,000 CaBP, suggesting that a major role of vitamin D in renal function is regulation of calcium transport at the distal tubule.	Vitamin D	161-170	hippocalcin	Rattus norvegicus	123-127
2411531-0	1985	Cell-free translational analysis of messenger ribonucleic acid coding for vitamin D-dependent rat renal calcium-binding protein.	Vitamin D	74-83	hippocalcin	Rattus norvegicus	104-127
2411531-8	1985	When 100 ng 1,25-(OH)2D3 were injected for 7 days to 8-week-old vitamin D-deficient rats, there was a 4-fold increase in CaBP mRNA levels in the kidney (quantitated by densitometry of immunoprecipitates analyzed on sodium dodecyl sulfate-polyacrylamide gels).	Vitamin D	64-73	hippocalcin	Rattus norvegicus	121-125
2989641-1	1985	The biologically active vitamin D metabolite, 1,25-(OH) 2D3 suppressed phytohaemagglutinin (PHA)-induced lymphocyte proliferation dose-dependently (0.1 nM-100 nM), and decreased the OKT4+/OKT8+ ratio and transferrin-receptor-positive (OKT9+) cells.	Vitamin D	24-33	transferrin	Mus musculus	204-215
2990230-14	1985	The radioactive vitamin D3 recovered in the lymph fraction with d greater than 1.006 (free of chylomicrons) coeluted with purified rat serum binding protein for vitamin D and its metabolites (DBP) from an antirat DBP column.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Rattus norvegicus	192-195
2990230-14	1985	The radioactive vitamin D3 recovered in the lymph fraction with d greater than 1.006 (free of chylomicrons) coeluted with purified rat serum binding protein for vitamin D and its metabolites (DBP) from an antirat DBP column.	Vitamin D	16-25	D-box binding PAR bZIP transcription factor	Rattus norvegicus	213-216
3891315-7	1985	The concomitant presence in the endodermal cells of this DBP, of the 1,25-dihydroxyvitamin D receptor, and of the system hydroxylating vitamin D metabolites in position 24, certainly has considerable physiological significance.	Vitamin D	83-92	D-box binding PAR bZIP transcription factor	Rattus norvegicus	57-60
3919968-1	1985	A simple method for the quantification of the vitamin D binding capacity (concentration of vitamin D binding protein, DBP) in serum is described.	Vitamin D	46-55	GC vitamin D binding protein	Homo sapiens	91-116
6387694-8	1984	The kidney hydroxylase responsible for the final hydroxylation of the vitamin D hormone can be further stimulated by in vivo or in vitro administration of estradiol and, to a lesser extent, prolactin and parathyroid hormone.	Vitamin D	70-79	prolactin	Gallus gallus	190-199
6547042-1	1984	The human plasma protein binding vitamin D and its metabolites (Gc globulin; group-specific component) has been isolated from human plasma by column affinity chromatography on gels to which monomeric actin was covalently attached.	Vitamin D	33-42	GC vitamin D binding protein	Homo sapiens	64-75
6608994-5	1984	Both normal and Hyp mice responded to the vitamin D-deficient diet with a fall in serum calcium (p less than 0.01), significantly increased renal 1-OHase, and significantly decreased renal 24-OHase activities.	Vitamin D	42-51	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	189-197
6363517-1	1984	Vitamin D-dependent calcium-binding protein (CaBP) was localized in intestinal tissue sections obtained from rats raised under three different nutritional conditions: a normal vitamin D-replete diet, a vitamin D-free diet followed by supplementation with vitamin D3, or a vitamin D-free diet without additional supplementation.	Vitamin D	176-185	hippocalcin	Rattus norvegicus	20-43
6363517-1	1984	Vitamin D-dependent calcium-binding protein (CaBP) was localized in intestinal tissue sections obtained from rats raised under three different nutritional conditions: a normal vitamin D-replete diet, a vitamin D-free diet followed by supplementation with vitamin D3, or a vitamin D-free diet without additional supplementation.	Vitamin D	176-185	hippocalcin	Rattus norvegicus	45-49
6363517-1	1984	Vitamin D-dependent calcium-binding protein (CaBP) was localized in intestinal tissue sections obtained from rats raised under three different nutritional conditions: a normal vitamin D-replete diet, a vitamin D-free diet followed by supplementation with vitamin D3, or a vitamin D-free diet without additional supplementation.	Vitamin D	202-211	hippocalcin	Rattus norvegicus	20-43
6363517-1	1984	Vitamin D-dependent calcium-binding protein (CaBP) was localized in intestinal tissue sections obtained from rats raised under three different nutritional conditions: a normal vitamin D-replete diet, a vitamin D-free diet followed by supplementation with vitamin D3, or a vitamin D-free diet without additional supplementation.	Vitamin D	202-211	hippocalcin	Rattus norvegicus	45-49
6363517-1	1984	Vitamin D-dependent calcium-binding protein (CaBP) was localized in intestinal tissue sections obtained from rats raised under three different nutritional conditions: a normal vitamin D-replete diet, a vitamin D-free diet followed by supplementation with vitamin D3, or a vitamin D-free diet without additional supplementation.	Vitamin D	202-211	hippocalcin	Rattus norvegicus	20-43
6363517-1	1984	Vitamin D-dependent calcium-binding protein (CaBP) was localized in intestinal tissue sections obtained from rats raised under three different nutritional conditions: a normal vitamin D-replete diet, a vitamin D-free diet followed by supplementation with vitamin D3, or a vitamin D-free diet without additional supplementation.	Vitamin D	202-211	hippocalcin	Rattus norvegicus	45-49
6363517-6	1984	In rats raised on a vitamin D-deficient diet then supplemented with vitamin D3, CaBP was present in cells at the full depth of the crypts and in absorptive cells along the total villus length in the duodenum.	Vitamin D	20-29	hippocalcin	Rattus norvegicus	80-84
6095615-0	1984	Vitamin D activates (Na+-K+)ATPase: a possible regulation of phosphate and calcium uptake by cultured embryonic chick small intestine.	Vitamin D	0-9	ATPase Na+/K+ transporting subunit alpha 1	Gallus gallus	21-34
6624003-4	1983	The deficiency of food proteins was shown to lead to substantial changes in the content of vitamin D-dependent CBP and calcium-binding activity of mucoproteins.	Vitamin D	91-100	hippocalcin	Rattus norvegicus	111-114
6176188-0	1982	Human serum binding protein for vitamin D and its metabolites (DBP): evidence that actin is the DBP binding component in human skeletal muscle.	Vitamin D	32-41	growth hormone receptor	Homo sapiens	6-27
6895734-2	1982	Vitamin D action at the molecular level can be studied by analyzing the response in terms of calcium-binding protein (CaBP; Mr congruent to 9000) biosynthesis to exogenous 1,25-dihydroxyvitamin D3 (1,25-(OH)2-D3).	Vitamin D	0-9	hippocalcin	Rattus norvegicus	93-116
6895734-2	1982	Vitamin D action at the molecular level can be studied by analyzing the response in terms of calcium-binding protein (CaBP; Mr congruent to 9000) biosynthesis to exogenous 1,25-dihydroxyvitamin D3 (1,25-(OH)2-D3).	Vitamin D	0-9	hippocalcin	Rattus norvegicus	118-122
6895734-3	1982	In vitamin D-replete animals, the CaBP response occurs within 1 h of intraperitoneal injection when the animals have been fed a high-calcium diet (III), but in 7 h if the animals have been fed a low-calcium diet(I).	Vitamin D	3-12	hippocalcin	Rattus norvegicus	34-38
6895734-5	1982	In vitamin D-deficient animals, exogenous 1,25-(OH)2-D3 evokes a CaBP response that occurs 7-8 h after treatment and is transcriptional in nature.	Vitamin D	3-12	hippocalcin	Rattus norvegicus	65-69
6895734-7	1982	Peak response times parallel those found with CaBP biosynthesis, i.e., 3 h in cells from vitamin D-replete animals fed diet III, 7 h in cells from vitamin D-replete animals fed diet I, and 12 h in cells from vitamin D-deficient animal.	Vitamin D	89-98	hippocalcin	Rattus norvegicus	46-50
6247135-3	1980	Rats fed a vitamin D-deficient diet containing a sufficient amount of calcium and phosphorus were found to have a normal DBP (binding protein for vitamin D and its hydroxylated metabolites) pattern indistinguishable from that of rats receiving the same diet but supplemented with a weekly injection of 500 microgram vitamin D3.	Vitamin D	11-20	D-box binding PAR bZIP transcription factor	Rattus norvegicus	121-124
6247135-4	1980	Rats fed a vitamin D-deficient, low calcium, low phosphorus diet developed severe hypocalcemia and growth retardation, but their DBP pattern was not significantly different from that of rats fed the same diet but supplemented with a weekly injection of 500 microgram vitamin D3.	Vitamin D	11-20	D-box binding PAR bZIP transcription factor	Rattus norvegicus	129-132
477606-1	1979	To study the role of the vitamin D-endocrine system during the perinatal period, we monitored vitamin D-dependent calcium-binding protein (CaBP) in rat intestine by radial immunodiffusion and polyacrylamide disc gel electrophoresis.	Vitamin D	94-103	hippocalcin	Rattus norvegicus	114-137
477606-1	1979	To study the role of the vitamin D-endocrine system during the perinatal period, we monitored vitamin D-dependent calcium-binding protein (CaBP) in rat intestine by radial immunodiffusion and polyacrylamide disc gel electrophoresis.	Vitamin D	94-103	hippocalcin	Rattus norvegicus	139-143
477606-6	1979	These data demonstrate that although vitamin D-dependent CaBP is low in preweaned rats, the rat intestine is responsive to exogeneous 1,25-dihydroxyvitamin D3 at least as early as day 15 after birth.	Vitamin D	37-46	hippocalcin	Rattus norvegicus	57-61
477606-7	1979	The close temporal correspondence between the increases in CaBP and previously reported changes in calcium transport and vitamin D metabolism suggest that the vitamin D-endocrine system plays a role in postnatal intestinal maturation and adaptation during the weaning period.	Vitamin D	159-168	hippocalcin	Rattus norvegicus	59-63
109444-0	1979	Human serum binding protein for vitamin D and its metabolites.	Vitamin D	32-41	growth hormone receptor	Homo sapiens	6-27
571870-0	1979	Human serum binding protein for vitamin D and its metabolites.	Vitamin D	32-41	growth hormone receptor	Homo sapiens	6-27
92374-1	1979	The binding properties towards vitamin D metabolites of plasma from individuals with the three common Gc-globulin phenotypes, Gc-1, Gc-2 and Gc-2-1, have been found to be identical.	Vitamin D	31-40	GC vitamin D binding protein	Homo sapiens	102-113
309418-0	1979	Vitamin D dependence of in vivo calcium transport and mucosal calcium binding protein in rat large intestine.	Vitamin D	0-9	hippocalcin	Rattus norvegicus	62-85
309418-8	1979	Mucosal calcium binding protein was higher in cecum than in colon in both groups and was higher in vitamin-D-treated than in vitamin D-deficient animals in both segments.	Vitamin D	99-108	hippocalcin	Rattus norvegicus	8-31
309418-8	1979	Mucosal calcium binding protein was higher in cecum than in colon in both groups and was higher in vitamin-D-treated than in vitamin D-deficient animals in both segments.	Vitamin D	125-134	hippocalcin	Rattus norvegicus	8-31
309418-10	1979	In both cecum and colon, mucosal calcium binding protein increases with vitamin D treatment.	Vitamin D	72-81	hippocalcin	Rattus norvegicus	33-56
955248-0	1976	Effect of prolactin on vitamin D metabolism.	Vitamin D	23-32	prolactin	Gallus gallus	10-19
1248445-0	1976	Sites of clearance of endogenous parathyroid hormone in the vitamin D-deficient dog.	Vitamin D	60-69	parathyroid hormone	Canis lupus familiaris	33-52
34055120-11	2021	Subjects with moderate to severe LBP showed a significant increase in adiposity markers, lower PA, muscle performance, malnutrition, and lower Ca and vitamin D intake compared to normal controls.	Vitamin D	150-159	lipopolysaccharide binding protein	Homo sapiens	33-36
34055120-15	2021	Conclusions: In older adults with vitamin D deficiency, the severity of LBP was significantly associated with the expression of circulating miRNAs, adiposity, bone metabolism, inflammation, and muscle performance.	Vitamin D	34-43	lipopolysaccharide binding protein	Homo sapiens	72-75
33990871-2	2021	Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection   Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites What is New?	Vitamin D	0-9	GC vitamin D binding protein	Homo sapiens	104-129
33990871-2	2021	Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection   Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites What is New?	Vitamin D	226-235	GC vitamin D binding protein	Homo sapiens	104-129
33982113-1	2021	BACKGROUND: Lactoferrin (LF) has been shown to promote bone anabolism, and the vitamin D receptor (VDR) mediates the effects of vitamin D on bone.	Vitamin D	79-88	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	99-102
33759562-7	2021	Collectively, these data suggest that vitamin D/VDR signaling relieves colitis development in animal models, at least in part, by suppressing HIF-1alpha expression in colonic epithelial cells.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	48-51
34008824-0	2021	Vitamin D Supplementation Induces Cardiac Remodeling in Rats: Association with Thioredoxin-Interacting Protein and Thioredoxin.	Vitamin D	0-9	thioredoxin interacting protein	Rattus norvegicus	79-110
33713016-0	2021	Correction to: Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-beta/Smad signaling in myocardial infarction model of rats.	Vitamin D	26-35	transforming growth factor alpha	Rattus norvegicus	103-111
33741398-0	2021	An intronic DHCR7 genetic polymorphism associates with vitamin D serum level and incidence of acute coronary syndrome.	Vitamin D	55-64	7-dehydrocholesterol reductase	Homo sapiens	12-17
33741398-5	2021	AIM: This study aims to correlate two polymorphisms in the DHCR7/NADSYN1 genetic locus with levels of circulatory vitamin D and the presentation of ACS in an Egyptian population.	Vitamin D	114-123	7-dehydrocholesterol reductase	Homo sapiens	59-64
33741398-5	2021	AIM: This study aims to correlate two polymorphisms in the DHCR7/NADSYN1 genetic locus with levels of circulatory vitamin D and the presentation of ACS in an Egyptian population.	Vitamin D	114-123	NAD synthetase 1	Homo sapiens	65-72
33741398-9	2021	Allele A of the DHCR7 polymorphism was found to correlate with serum vitamin D deficiency and incidence of ACS classes: NSTEMI, STEMI and unstable angina, when compared to allele G. On the other hand, the NADSYN1 polymorphism rs2276360 correlated with serum 25(OH)D3 deficiency.	Vitamin D	69-78	7-dehydrocholesterol reductase	Homo sapiens	16-21
33741398-11	2021	CONCLUSION: We conclude that rs11606033, which is an intronic SNP between exon 4 and exon 5 of the DHCR7 gene, influences vitamin D serum abundance and more importantly ACS incidence.	Vitamin D	122-131	7-dehydrocholesterol reductase	Homo sapiens	99-104
33931018-5	2021	Correlation between serum vitamin D levels and bronchiolitis severity was assessed via Modified Tal Score and length of hospital stay (LOS).	Vitamin D	26-35	transaldolase 1	Homo sapiens	96-99
33895867-6	2021	An increase in Fibroblast Growth Factor 23 (FGF23) with analogue administration was found in all 3 studies reporting FGF23, but was unaltered in 4 studies with vitamin D or calcifediol.	Vitamin D	160-169	fibroblast growth factor 23	Homo sapiens	44-49
33882819-3	2021	Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR).	Vitamin D	18-27	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	63-70
33882819-3	2021	Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR).	Vitamin D	18-27	7-dehydrocholesterol reductase	Homo sapiens	106-111
33923969-5	2021	In 54 women (26.3% of all women) with a risk of NTDs, multivitamin supplementation containing folic acid and vitamin D for one month increased folate level (5.8 +- 0.9 to 19.2 +- 4.0 ng/mL, p < 0.0001) and decreased the homocysteine level (8.2 +- 3.1 to 5.8 +- 0.8 nmol/mL, p < 0.0001) to minimize the risk of NTDs in all women, regardless of MTHFR genotype.	Vitamin D	109-118	methylenetetrahydrofolate reductase	Homo sapiens	343-348
33853949-1	2021	Fibroblast growth factor 23 (FGF23), a hormone generally derived from bone, is important in phosphate and vitamin D homeostasis.	Vitamin D	106-115	fibroblast growth factor 23	Mus musculus	0-27
33853949-1	2021	Fibroblast growth factor 23 (FGF23), a hormone generally derived from bone, is important in phosphate and vitamin D homeostasis.	Vitamin D	106-115	fibroblast growth factor 23	Mus musculus	29-34
33856702-3	2021	In this case-control study, we used precision vitamin D metabolite profiling based on LC-MS/MS of an expanded range of vitamin D metabolites - to screen German and French cohorts of hypercalcemia patients, to identify patients with altered vitamin D metabolism where involvement of CYP24A1 or SLC34A1 mutation had been ruled out, and possessed normal 25-OH-D3 :24,25-(OH)2 D3 ratios.	Vitamin D	46-55	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	282-289
33836827-8	2021	Treatment of hADMSCs with vitamin D plus BPA (0.1 nM) significantly inhibited the induction of PPARgamma, C/EBP beta, C/EBP alpha, and FASN related to adipocyte differentiation and development.	Vitamin D	26-35	fatty acid synthase	Homo sapiens	135-139
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	vitamin D receptor	Homo sapiens	43-46
33836827-11	2021	Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4.	Vitamin D	156-165	vitamin D receptor	Homo sapiens	185-188
33832495-2	2021	The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores.	Vitamin D	159-168	CD8a molecule	Homo sapiens	238-241
33418034-0	2021	Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice.	Vitamin D	87-96	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	71-74
33607405-4	2021	As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I"d believe that vitamin D binding protein (DBP) is maybe also involved.	Vitamin D	60-69	GC vitamin D binding protein	Homo sapiens	167-192
33607405-4	2021	As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I"d believe that vitamin D binding protein (DBP) is maybe also involved.	Vitamin D	98-107	GC vitamin D binding protein	Homo sapiens	167-192
33932791-0	2021	Vitamin D binding protein: A key regulator of vitamin D deficiency among patients with pneumonia.	Vitamin D	46-55	GC vitamin D binding protein	Homo sapiens	0-25
33757895-2	2021	25(OH)D is a quantitatively important metabolite and widely used clinical marker of vitamin D status and is regulated by vitamin D binding protein (VDBP).	Vitamin D	84-93	GC vitamin D binding protein	Homo sapiens	148-152
33741834-12	2022	Moreover, fractures were substantially more frequent in children with vitamin D deficiency (<20 ng/mL, chi2: 7.781, df: 1, P = 0.005).	Vitamin D	70-79	thrombopoietin	Mus musculus	99-101
33730772-1	2021	OBJECTIVES: To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	43-46
33735953-1	2021	OBJECTIVES: To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	43-46
33731726-1	2021	Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine hormone that regulates phosphate and vitamin D metabolism.	Vitamin D	101-110	fibroblast growth factor 23	Mus musculus	0-27
33731726-1	2021	Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine hormone that regulates phosphate and vitamin D metabolism.	Vitamin D	101-110	fibroblast growth factor 23	Mus musculus	29-34
33712053-4	2021	RESULTS: Our results showed that vitamin D receptor (VDR), as a mediator of most actions of 1,25-dihydroxyvitamin D3, glucose trasporter-4 (GLUT4),and fatty acid binding protein-4 (FABP4) was expressed in vitamin D-treated hASCs.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
33791222-9	2021	Additionally, we also found that the expression of CYP24A1, the main enzyme determining the biological half-life of calcitriol, was significantly inhibited by miR-1278, according to data from clinical, RNA-seq and functional assays, which allowed miR-1278 to sensitize CRC cells to vitamin D.	Vitamin D	282-291	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	51-58
33438017-1	2021	We summarize here lessons learned from studies on skeletal and extra-skeletal functions of vitamin D in hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) patients with a mutant, nonfunctioning vitamin D receptor (VDR).	Vitamin D	91-100	vitamin D receptor	Homo sapiens	204-222
33438017-1	2021	We summarize here lessons learned from studies on skeletal and extra-skeletal functions of vitamin D in hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) patients with a mutant, nonfunctioning vitamin D receptor (VDR).	Vitamin D	91-100	vitamin D receptor	Homo sapiens	159-162
33438017-15	2021	HVDRR patients provide a unique opportunity to study the role of the VDR and the role of vitamin D in various human systems.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	1-4
33713706-7	2021	Additionally, we found that vitamin D dietary intervention regulated intestinal fibrosis by modulating the intestinal expression of VDR.	Vitamin D	28-37	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	132-135
33664952-2	2021	Vitamin D is a key mediator in inflammatory and infectious diseases, which VDR mediates its biological effect.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	75-78
33664952-11	2021	Conclusions: Strong negative correlation between VDR and HMGB1 in different immunodeficiency statuses suggesting an important role of vitamin D in inflammation control in HIV infection.	Vitamin D	134-143	vitamin D receptor	Homo sapiens	49-52
33578813-1	2021	Skeletal muscle cells, albeit classified as vitamin D receptor (VDR)-poor cells, are finely controlled by vitamin D through genomic and non-genomic mechanisms.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	64-67
33568925-8	2021	Higher FLI scores [OR= 0.77 (0.07), p<0.01] and ALP levels [beta= -0.03 (-0.06, -0.01), p<0.01] associated to lower vitamin D levels.	Vitamin D	116-125	ATHS	Homo sapiens	48-51
33183376-6	2021	The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	84-102
33183376-6	2021	The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	104-107
33485603-11	2021	CONCLUSION: Our results suggest that FokI and TaqI polymorphisms of VDR are associated with MS risk and TaqI polymorphism is associated with Vitamin D levels in MS patients.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	68-71
33295878-4	2021	Circulatory FGF23 is high in patients with these hypophosphatemic diseases while FGF23 is rather low in those with chronic hypophosphatemia from other causes such as vitamin D deficiency.	Vitamin D	166-175	fibroblast growth factor 23	Homo sapiens	81-86
33295878-9	2021	Phosphate and active vitamin D have been used for patients with hypophosphatemic diseases caused by excessive actions of FGF23 including TIO patients with unresectable tumors.	Vitamin D	21-30	fibroblast growth factor 23	Homo sapiens	121-126
33258480-7	2021	Vitamin-D exerts its actions through the Vitamin-D-receptor (VDR), the expression of which was recently confirmed in skeletal muscle, and its down-regulation is linked to reduced muscle mass and functional decline.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	41-59
33258480-7	2021	Vitamin-D exerts its actions through the Vitamin-D-receptor (VDR), the expression of which was recently confirmed in skeletal muscle, and its down-regulation is linked to reduced muscle mass and functional decline.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	61-64
33428175-0	2021	Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-beta/Smad signaling in myocardial infarction model of rats.	Vitamin D	11-20	transforming growth factor alpha	Rattus norvegicus	88-96
33188595-0	2021	The Vitamin D Metabolite Ratio Is Independent of Vitamin D Binding Protein Concentration.	Vitamin D	4-13	GC vitamin D binding protein	Homo sapiens	49-74
33188595-1	2021	BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] may be a poor marker of vitamin D status as it reflects differences in vitamin D binding protein (VDBP) between individuals.	Vitamin D	22-31	GC vitamin D binding protein	Homo sapiens	113-138
33188595-1	2021	BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] may be a poor marker of vitamin D status as it reflects differences in vitamin D binding protein (VDBP) between individuals.	Vitamin D	22-31	GC vitamin D binding protein	Homo sapiens	140-144
33573279-0	2021	rs6837671A>G in FAM13A Is a Trans-Ethnic Genetic Variant Interacting with Vitamin D Levels to Affect Chronic Obstructive Pulmonary Disease.	Vitamin D	74-83	family with sequence similarity 13 member A	Homo sapiens	16-22
33519140-2	2021	Vitamin-D-binding protein (VDBP) is a multifunctional glycoprotein mainly synthesized in the liver and the major transport protein for vitamin D and its metabolites.	Vitamin D	135-144	GC vitamin D binding protein	Homo sapiens	0-25
33519140-2	2021	Vitamin-D-binding protein (VDBP) is a multifunctional glycoprotein mainly synthesized in the liver and the major transport protein for vitamin D and its metabolites.	Vitamin D	135-144	GC vitamin D binding protein	Homo sapiens	27-31
33952739-10	2021	Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group.	Vitamin D	73-82	C-reactive protein, pentraxin-related	Mus musculus	16-34
33952739-10	2021	Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group.	Vitamin D	73-82	C-reactive protein, pentraxin-related	Mus musculus	36-39
32270535-0	2021	Maternal Vitamin D Deficiency Increases Intestinal Permeability and Programs Wnt/beta-Catenin Pathway in BALB/C Mice.	Vitamin D	9-18	catenin (cadherin associated protein), beta 1	Mus musculus	81-93
32270535-5	2021	RESULTS: Maternal vitamin D deficiency increased intestinal permeability in offspring, which corresponded with the decreased expression of the tight junction protein claudin-1.	Vitamin D	18-27	claudin 1	Mus musculus	166-175
32270535-6	2021	Maternal vitamin D deficiency also repressed the messenger RNA expression of wingless/integrated family member 3a (Wnt3a) and the protein expression of nuclear beta-catenin.	Vitamin D	9-18	catenin (cadherin associated protein), beta 1	Mus musculus	160-172
32270535-8	2021	The activation of the Wnt/beta-catenin pathway protected against the impairment of intestinal permeability induced by maternal vitamin D deficiency.	Vitamin D	127-136	catenin (cadherin associated protein), beta 1	Mus musculus	26-38
33214002-0	2021	Is there an underlying link between COVID-19, ACE2, oxytocin and vitamin D?	Vitamin D	65-74	oxytocin/neurophysin I prepropeptide	Homo sapiens	52-60
33446057-1	2021	Vitamin D (VDR)-mediated signaling contributes to the cell signaling pathways that affect cancer development.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	11-14
33633942-0	2021	Vitamin D receptor gene ApaI and FokI polymorphisms and its association with inflammation and oxidative stress in vitamin D sufficient Caucasian Spanish children.	Vitamin D	114-123	vitamin D receptor	Homo sapiens	0-18
33633942-6	2021	The focus of this study was to explore associations between VDR single nucleotide polymorphisms (SNPs) and markers of inflammation and oxidative stress in vitamin D sufficient children.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	60-63
33396382-12	2020	To move forward, we need well-designed therapeutic studies to examine whether enhanced vitamin D will restore functions of VDR and microbiome in inhibiting chronic inflammation.	Vitamin D	87-96	vitamin D receptor	Homo sapiens	123-126
33377261-18	2021	Interestingly, CYP24A1 limits the action of the active form of vitamin D, which is an anti-proliferative factor in cancer.	Vitamin D	63-72	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	15-22
32747610-4	2020	Vitamin D can inhibit the protein expression of nuclear factor beta; improve arterial stiffness; decrease renin-angiotensin-aldosterone system activity, parathyroid hormone levels, inflammatory cytokines, 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)-reductase, and lanosterol 14 beta-demethylase enzyme activity; increase the activity of lipoprotein lipase; alter gene expression in C2C12 cells; and improve phospholipid metabolism and mitochondrial oxidation.	Vitamin D	0-9	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	205-261
33402842-13	2020	Conclusion: In the aggregate, these data suggest that interferons have a regulatory influence on vitamin D status that can contribute to VDR signaling in PBMCs.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	137-140
33374582-5	2020	Plasma calcitriol concentrations are inversely proportional to caloric intake due to modulation by FGF23 of the enzymes implicated in vitamin D metabolism.	Vitamin D	134-143	fibroblast growth factor 23	Homo sapiens	99-104
33348854-2	2020	Vitamin D is a potent immunonutrient that through its main metabolite calcitriol, regulates the immunomodulation of macrophages, dendritic cells, T and B lymphocytes, which express the vitamin D receptor (VDR), and they produce and respond to calcitriol.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	185-203
33348854-2	2020	Vitamin D is a potent immunonutrient that through its main metabolite calcitriol, regulates the immunomodulation of macrophages, dendritic cells, T and B lymphocytes, which express the vitamin D receptor (VDR), and they produce and respond to calcitriol.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	205-208
33257569-2	2020	FGF23 stimulates the assembly of a signaling complex composed of alpha-Klotho (KLA) and FGF receptor (FGFR) resulting in kinase activation, regulation of phosphate homeostasis, and vitamin D levels.	Vitamin D	181-190	fibroblast growth factor 23	Homo sapiens	0-5
33257569-2	2020	FGF23 stimulates the assembly of a signaling complex composed of alpha-Klotho (KLA) and FGF receptor (FGFR) resulting in kinase activation, regulation of phosphate homeostasis, and vitamin D levels.	Vitamin D	181-190	klotho	Homo sapiens	71-77
33306729-1	2020	BACKGROUND: Concentrations of fibroblast growth factor 23 (FGF-23), a hormone that regulates phosphorus and vitamin D metabolism, increase as kidney function declines.	Vitamin D	108-117	fibroblast growth factor 23	Homo sapiens	30-57
33306729-1	2020	BACKGROUND: Concentrations of fibroblast growth factor 23 (FGF-23), a hormone that regulates phosphorus and vitamin D metabolism, increase as kidney function declines.	Vitamin D	108-117	fibroblast growth factor 23	Homo sapiens	59-65
33365026-8	2020	Expression of IL-23A and vitamin D pathway genes VDR and CYP27B1 varied by HLA genotype and was lower in healthy individuals with high-risk HLA (p = 0.0025; p = 0.04), while healthy controls with low-risk HLA showed a stronger IL-10 and CD14 expression (p = 0.01; p = 0.03).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	49-52
33365026-8	2020	Expression of IL-23A and vitamin D pathway genes VDR and CYP27B1 varied by HLA genotype and was lower in healthy individuals with high-risk HLA (p = 0.0025; p = 0.04), while healthy controls with low-risk HLA showed a stronger IL-10 and CD14 expression (p = 0.01; p = 0.03).	Vitamin D	25-34	interleukin 10	Homo sapiens	227-232
33288743-5	2020	Moreover, we show that the vitamin D analogue ZK168281 enhances the interaction between VDR and WBP4 in the cytosol, and normalizes the expression of VDR target genes and serum calcium levels in 1alpha,25(OH)2D3-intoxicated mice.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	88-91
33288743-5	2020	Moreover, we show that the vitamin D analogue ZK168281 enhances the interaction between VDR and WBP4 in the cytosol, and normalizes the expression of VDR target genes and serum calcium levels in 1alpha,25(OH)2D3-intoxicated mice.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	150-153
32861664-2	2020	Calcitriol, or 1,25(OH)2D3, the bioactive form of vitamin D (VD), can activate p21 expression and attenuate cardiac hypertrophy.	Vitamin D	50-59	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	79-82
33273558-1	2020	The vitamin D receptor (VDR), coded by the VDR gene, plays a pivotal role in executing cellular functions when bound by the active form of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
33273558-1	2020	The vitamin D receptor (VDR), coded by the VDR gene, plays a pivotal role in executing cellular functions when bound by the active form of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	43-46
32919110-1	2020	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	27-54
32919110-1	2020	BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism.	Vitamin D	102-111	fibroblast growth factor 23	Homo sapiens	56-61
33186763-3	2020	In the last decade mutations in CYP24A1, the gene responsible for vitamin D inactivation, were described as the main molecular cause of IIH.	Vitamin D	66-75	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	32-39
33259013-4	2020	Cytochrome enzymes CYP27B1 and CYP24A1 that perform the final conversion of the circulating form of vitamin D, 25-hydroxyvitamin D (25-OHD) to the active VDR ligand, 1a,25-dihydroxyvitamin D and the catabolism of it to inactive 24,25-dihydroxyvitamin D, respectively, are also expressed in breast cancer tissues.	Vitamin D	100-109	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	31-38
33259013-4	2020	Cytochrome enzymes CYP27B1 and CYP24A1 that perform the final conversion of the circulating form of vitamin D, 25-hydroxyvitamin D (25-OHD) to the active VDR ligand, 1a,25-dihydroxyvitamin D and the catabolism of it to inactive 24,25-dihydroxyvitamin D, respectively, are also expressed in breast cancer tissues.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	154-157
33282119-4	2020	Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency.	Vitamin D	259-268	vitamin D receptor	Homo sapiens	0-18
32583376-0	2020	Influence of Stress on the Vitamin D-Vitamin D Receptor System, Macrophages, and the Local Inflammatory Milieu in Endometriosis.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	37-55
32583376-11	2020	Macrophage infiltration correlated with vesicle area (p < 0.05), and peritoneal vitamin D levels correlated with vesicle VDR expression (r = 0.81, p < 0.01).	Vitamin D	80-89	vitamin D receptor	Homo sapiens	121-124
33266022-8	2020	RESULTS: High-dose vitamin D treatment alone and combined with infliximab decreased the IL17A, IFNgamma and IL10 expression.	Vitamin D	19-28	interleukin 17A	Homo sapiens	88-93
33266022-8	2020	RESULTS: High-dose vitamin D treatment alone and combined with infliximab decreased the IL17A, IFNgamma and IL10 expression.	Vitamin D	19-28	interleukin 10	Homo sapiens	108-112
33266022-11	2020	CONCLUSIONS: High-dose vitamin D as monotherapy and combined with infliximab decreases IL17A, IFNgamma and IL-10 expression in mucosa within treatment groups.	Vitamin D	23-32	interleukin 17A	Homo sapiens	87-92
33266022-11	2020	CONCLUSIONS: High-dose vitamin D as monotherapy and combined with infliximab decreases IL17A, IFNgamma and IL-10 expression in mucosa within treatment groups.	Vitamin D	23-32	interleukin 10	Homo sapiens	107-112
33294462-2	2020	Vitamin D levels in DN patients are very low due to the decrease in the synthesis and activity of 1-alpha hydroxylase in the proximal tubule cells and decrease in the vitamin D receptor abundance.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	167-185
33329593-8	2020	Overall, our data show a crosstalk between vitamin D and CD46 that allows a preferential effect of Vitamin D on Tr1 cells, providing novel key insights into the role of an important modifiable environmental factor in MS.	Vitamin D	43-52	thioredoxin reductase 1	Homo sapiens	112-115
33329593-8	2020	Overall, our data show a crosstalk between vitamin D and CD46 that allows a preferential effect of Vitamin D on Tr1 cells, providing novel key insights into the role of an important modifiable environmental factor in MS.	Vitamin D	99-108	thioredoxin reductase 1	Homo sapiens	112-115
33228578-1	2020	BACKGROUND: Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations.	Vitamin D	12-21	GC vitamin D binding protein	Homo sapiens	59-84
33211721-7	2020	We found that human arteries express a functionally active vitamin D system, including the VDR, 1alpha-hydroxylase and 24-hydroxylase (24-OHase) components and these were dysregulated in CKD arteries.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	91-94
33211721-7	2020	We found that human arteries express a functionally active vitamin D system, including the VDR, 1alpha-hydroxylase and 24-hydroxylase (24-OHase) components and these were dysregulated in CKD arteries.	Vitamin D	59-68	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	135-143
33227893-1	2020	Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors gamma and alpha (RORgamma and RORalpha), show anticancer properties.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	46-64
33227893-1	2020	Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors gamma and alpha (RORgamma and RORalpha), show anticancer properties.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	66-69
33227893-1	2020	Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors gamma and alpha (RORgamma and RORalpha), show anticancer properties.	Vitamin D	0-9	RAR related orphan receptor A	Homo sapiens	114-152
33227068-0	2020	Association between vitamin D and ovarian cancer development in BRCA1 mutation carriers.	Vitamin D	20-29	BRCA1 DNA repair associated	Homo sapiens	64-69
33165606-11	2021	Higher vitamin D levels in those in endoscopic remission compared with lower levels in those with active inflammation suggests that the impact of VDR gene SNP on disease activity may be overcome with replacement therapy.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	146-149
32942038-3	2020	Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	82-100
32942038-3	2020	Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	102-105
32942038-7	2020	Further, intestinal VDR expression is inversely correlated with the severity of inflammation in patients with IBD, which might compromise the positive effects of vitamin D signaling in patients with flaring disease.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	20-23
33131491-2	2020	We hypothesized that vitamin D intake should refer to vitamin D receptor (VDR) expression.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	54-72
32964520-1	2020	Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism.	Vitamin D	114-123	fibroblast growth factor 23	Homo sapiens	0-27
32964520-1	2020	Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism.	Vitamin D	114-123	fibroblast growth factor 23	Homo sapiens	29-34
33413767-12	2020	CONCLUSION: The vitamin D-binding protein gene rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency in college students, and A-allele is a risk factor accounting for vitamin D insufficiency and deficiency in college students.	Vitamin D	97-106	GC vitamin D binding protein	Homo sapiens	16-41
33105665-2	2020	Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP).	Vitamin D	50-59	GC vitamin D binding protein	Homo sapiens	133-158
33105665-2	2020	Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP).	Vitamin D	50-59	GC vitamin D binding protein	Homo sapiens	160-164
33463118-8	2020	Vitamin D Intervention significantly (p<0.05) could increase the expression of Foxp3, IL-10, and TGF-beta1 gene in the CD4+ T cells of mice comparing with the control group.	Vitamin D	0-9	CD4 antigen	Mus musculus	119-122
33067526-5	2020	Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	0-18
33067526-5	2020	Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	20-23
33067526-5	2020	Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	117-120
33067526-5	2020	Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D.	Vitamin D	184-193	vitamin D receptor	Homo sapiens	0-18
33067526-5	2020	Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D.	Vitamin D	184-193	vitamin D receptor	Homo sapiens	20-23
33067526-5	2020	Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D.	Vitamin D	184-193	vitamin D receptor	Homo sapiens	117-120
33088927-4	2020	Relevant to potential behavioral effects of vitamin D, urolithin A elicits enhancement of 1,25D-dependent mRNA encoding tryptophan hydroxylase-2 (TPH2), the serotonergic neuron-expressed initial enzyme in tryptophan metabolism to serotonin.	Vitamin D	44-53	tryptophan hydroxylase 2	Rattus norvegicus	146-150
33043047-2	2020	Data regarding the effect of vitamin D on elastin degradation are lacking.	Vitamin D	29-38	elastin	Homo sapiens	42-49
33043047-3	2020	Based on the vitamin"s anti-inflammatory properties, we hypothesised that vitamin D supplementation reduces elastin degradation, particularly in vitamin D-deficient COPD patients.	Vitamin D	74-83	elastin	Homo sapiens	108-115
33043047-4	2020	We assessed the effect of vitamin D status and supplementation on elastin degradation by measuring plasma desmosine, a biomarker of elastin degradation.	Vitamin D	26-35	elastin	Homo sapiens	66-73
33043047-10	2020	Contrary to our hypothesis, the intervention decelerated elastin degradation in vitamin D-sufficient COPD patients and not in vitamin D-deficient subjects.	Vitamin D	80-89	elastin	Homo sapiens	57-64
31874050-9	2020	Our results indicated that improvement in vitamin D status resulted in greater reductions in weight and MMP-9 during weight loss.	Vitamin D	42-51	matrix metallopeptidase 9	Homo sapiens	104-109
31971486-3	2020	We found that the major enzyme responsible for 1,25-Vitamin D3 synthesis, the 1-hydoxylase CYP27B1 (3,6-fold for OVA IP and 2,7-fold for OVA IP + EC), the vitamin D receptor (not altered) and the sensitive Vitamin D-mediated signalling target gene CYP24A1 (65-fold in OVA IP and 726-fold in OVA IP + EC) are upregulated after systemic and systemic plus topical allergic sensitization (OVA IP + EC).	Vitamin D	52-61	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	155-173
32846212-8	2020	Moreover, the neuroprotective effects of vitamin D and dehydroepiandrosterone (DHEA) are mediated through the binding to vitamin D receptor (VDR) and several intracellular and membrane receptors, respectively.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	121-139
33068876-0	2020	Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency.	Vitamin D	98-107	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	39-44
33070539-6	2020	Finally, we hypothesize that endothelial dysfunction relevant to vitamin D deficiency results from decreased binding of the vitamin D receptor with its ligand on the vascular endothelium and that it may be immune-mediated via increased interferon 1 alpha.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	124-142
32972010-8	2020	Vitamin D in tissues or brain cells can also modulate calbindin-D28K, parvalbumin, and calretinin, and is involved in immune function, thanks also to the combination with curcumin.	Vitamin D	0-9	parvalbumin	Homo sapiens	70-81
32938288-0	2020	Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson"s disease.	Vitamin D	20-29	7-dehydrocholesterol reductase	Homo sapiens	49-54
32938288-0	2020	Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson"s disease.	Vitamin D	20-29	NAD synthetase 1	Homo sapiens	55-62
32938288-5	2020	Our aim was to investigate the relevance of SNPs within the 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) locus and vitamin D 25-hydroxylase (CYP2R1) gene, which encode important enzymes that play a role in the vitamin D synthesis pathway, with PD and its clinical features.	Vitamin D	164-173	NAD synthetase 1	Homo sapiens	145-152
32938288-9	2020	CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients.	Vitamin D	143-152	7-dehydrocholesterol reductase	Homo sapiens	52-57
32938288-9	2020	CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients.	Vitamin D	143-152	NAD synthetase 1	Homo sapiens	58-65
32938288-9	2020	CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients.	Vitamin D	170-179	7-dehydrocholesterol reductase	Homo sapiens	52-57
32938288-9	2020	CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients.	Vitamin D	170-179	NAD synthetase 1	Homo sapiens	58-65
32900990-7	2020	Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance.	Vitamin D	215-224	vitamin D receptor	Homo sapiens	148-151
32900990-7	2020	Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance.	Vitamin D	215-224	SRY-box transcription factor 2	Homo sapiens	180-189
32900990-7	2020	Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance.	Vitamin D	215-224	SRY-box transcription factor 2	Homo sapiens	191-195
32900990-9	2020	These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling, resulting in a lack of efficacy of vitamin D in antineoplastic process.	Vitamin D	205-214	vitamin D receptor	Homo sapiens	155-158
32900990-9	2020	These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling, resulting in a lack of efficacy of vitamin D in antineoplastic process.	Vitamin D	261-270	vitamin D receptor	Homo sapiens	155-158
32516167-2	2020	The aim of the current study was to evaluate the functional impact of the genetic polymorphism rs2762939 of CYP24A1, the hydroxylase-enzyme modulating the inactivation of vitamin D, on the prevalence and extent of coronary artery disease (CAD).A consecutive cohort of patients undergoing coronary angiography in a single centre was included.	Vitamin D	171-180	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	108-115
31810868-10	2020	CONCLUSION: Collectively, the evidences from this study demonstrated that active VD could alleviate the development of NAFLD through blocking the p53-p21 signaling pathway, which provided a novel nutritional therapeutic insight for NAFLD.	Vitamin D	81-83	KRAS proto-oncogene, GTPase	Rattus norvegicus	150-153
32701599-2	2020	Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD).	Vitamin D	158-167	fibroblast growth factor 23	Homo sapiens	83-110
32701599-2	2020	Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD).	Vitamin D	158-167	fibroblast growth factor 23	Homo sapiens	112-117
31232112-9	2020	CONCLUSION: It is known that active vitamin D inhibits the growth of cancer cells by binding to vitamin D receptor with regulation of genes responsible for cell proliferation.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	96-114
32379895-2	2020	The action of calcitriol, the active metabolite of vitamin D, is mediated by the vitamin D receptor (VDR) that is present in most tissues.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	81-99
32379895-2	2020	The action of calcitriol, the active metabolite of vitamin D, is mediated by the vitamin D receptor (VDR) that is present in most tissues.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	101-104
32379895-13	2020	New vitamin D treatment studies that examine CRC should take in account confounding factors such as obesity or VDR genotypes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	111-114
32729975-2	2020	Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function.	Vitamin D	124-133	fibroblast growth factor 23	Homo sapiens	52-79
32729975-2	2020	Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function.	Vitamin D	124-133	fibroblast growth factor 23	Homo sapiens	81-86
32729975-2	2020	Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function.	Vitamin D	124-133	klotho	Homo sapiens	92-98
32729975-10	2020	In conclusion, this translational study suggests that FGF23 and Klotho influence gonadal function and testicular mineral ion homeostasis both directly and indirectly through systemic changes in vitamin D and mineral homeostasis.	Vitamin D	194-203	fibroblast growth factor 23	Homo sapiens	54-59
32729975-10	2020	In conclusion, this translational study suggests that FGF23 and Klotho influence gonadal function and testicular mineral ion homeostasis both directly and indirectly through systemic changes in vitamin D and mineral homeostasis.	Vitamin D	194-203	klotho	Homo sapiens	64-70
32504459-0	2020	Correction to: Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis.	Vitamin D	15-24	sirtuin 1	Homo sapiens	121-126
32803502-1	2020	CYP24A1 plays a role in strictly regulated vitamin D metabolism pathway and has been nominated as a prognostic biomarker for colorectal cancer (CRC).	Vitamin D	43-52	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
32880832-3	2020	Vitamin D is able to modulate a very specific immune response against MTB infection, and its action relies on vitamin D receptor (VDR) binding.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	110-128
32880832-3	2020	Vitamin D is able to modulate a very specific immune response against MTB infection, and its action relies on vitamin D receptor (VDR) binding.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	130-133
32880832-4	2020	Altered VDR forms may compromise vitamin D pathway and proper immune response after MTB infection.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	8-11
32952510-1	2020	Background: Polymorphisms in the gene encoding the vitamin D receptor (VDR) affect the protective role of vitamin D against many types of cancers, including colorectal cancer (CRC).	Vitamin D	51-60	vitamin D receptor	Homo sapiens	71-74
32866123-1	2020	Objectives Both CYP24A1 and SLC34A1 gene mutations are responsible for idiopathic infantile hypercalcemia, whereas loss-of-function mutations in CYP24A1 (25-OH-vitamin D-24-hydroxylase) lead to a defect in the inactivation of active 1.25(OH)2D; mutations in SLC34A1 encoding renal sodium phosphate cotransporter NaPi-IIa lead to primary renal phosphate wasting combined with an inappropriate activation of vitamin D.	Vitamin D	160-169	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-152
32867112-9	2020	RESULTS: Rs731236 (VDR gene) and rs7116978 (CYP2R1 gene) showed a significant association with vitamin D status.	Vitamin D	95-104	vitamin D receptor	Homo sapiens	19-22
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	OPA1, mitochondrial dynamin like GTPase	Mus musculus	138-153
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	OPA1, mitochondrial dynamin like GTPase	Mus musculus	155-159
32823606-10	2020	This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting-an important finding considering the essential roles of DHA and vitamin D.	Vitamin D	172-181	MMS	Homo sapiens	128-131
32823606-10	2020	This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting-an important finding considering the essential roles of DHA and vitamin D.	Vitamin D	282-291	MMS	Homo sapiens	128-131
32360157-10	2020	Moreover, adding Vitamin D could inhibit the expression concentrations of TPOAb, TGAb and IL-21.	Vitamin D	17-26	interleukin 21	Homo sapiens	90-95
32371216-0	2020	Vitamin D status influences transcriptional levels of RANKL and inflammatory biomarkers which are associated with activation of PBMC.	Vitamin D	0-9	TNF superfamily member 11	Homo sapiens	54-59
32781825-0	2020	Vitamin D in Hypothyroid Patients and Association between Vitamin D and Anti-TPO in Autoimmune Hypothyroidism.	Vitamin D	58-67	thyroid peroxidase	Homo sapiens	77-80
32781825-1	2020	BACKGROUND: To find out the incidence of vitamin D deficiency in autoimmune hypothyroidism and the correlation between vitamin D and anti-TPO antibodies.	Vitamin D	119-128	thyroid peroxidase	Homo sapiens	138-141
32781825-5	2020	RESULTS: Twenty-two of 101 patients were anti-TPO positive with a mean vitamin D level 10.86 +- 5.91 and mean anti-TPO 59.45 +- 12.46.	Vitamin D	71-80	thyroid peroxidase	Homo sapiens	46-49
32781825-6	2020	A negative correlation of r = -0.4949 was found between vitamin D and anti-TPO in patients with anti-TPO positive hypothyroidism.	Vitamin D	56-65	thyroid peroxidase	Homo sapiens	75-78
32781825-6	2020	A negative correlation of r = -0.4949 was found between vitamin D and anti-TPO in patients with anti-TPO positive hypothyroidism.	Vitamin D	56-65	thyroid peroxidase	Homo sapiens	101-104
32781825-7	2020	CONCLUSIONS: Low vitamin D levels were found in hypothyroid patients with severe deficiency seen in anti-TPO positive cases.	Vitamin D	17-26	thyroid peroxidase	Homo sapiens	105-108
32767348-5	2020	Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections.	Vitamin D	40-49	il-6	None	170-174
32576601-2	2020	Fibroblast growth factor 23 (FGF23) is often elevated in CKD, and may impair immune function directly or indirectly through proinflammatory and vitamin D-suppressing pathways.	Vitamin D	144-153	fibroblast growth factor 23	Homo sapiens	0-27
32576601-2	2020	Fibroblast growth factor 23 (FGF23) is often elevated in CKD, and may impair immune function directly or indirectly through proinflammatory and vitamin D-suppressing pathways.	Vitamin D	144-153	fibroblast growth factor 23	Homo sapiens	29-34
32413483-9	2020	The inhibitory or stimulatory effects of vitamin D on AGE receptors are mediated by various signaling pathways, MAPK/NF-kappaB, ADAM10/MMP9 and AT1R.	Vitamin D	41-50	matrix metallopeptidase 9	Homo sapiens	135-139
32413483-10	2020	In populations with chronic diseases and concomitant hypovitaminosis D, vitamin D supplementation can be used as a strategy to ameliorate AGE-mediated complications by modifying the AGE-RAGE and sRAGE systems.	Vitamin D	72-81	advanced glycosylation end-product specific receptor	Homo sapiens	186-190
32850381-10	2020	These findings provide support for inhibiting CYP24A1 as a potential approach to activate the vitamin D pathway in the prevention and therapy of ovarian cancer.	Vitamin D	94-103	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	46-53
32774770-2	2020	Although the vitamin D receptor (VDR), a ligand dependent transcription factor, is required for growth regulation by vitamin D, the specific target genes that trigger these effects are unknown.	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	33-36
32712621-10	2020	Vitamin D could decrease ROS level, apoptotic neuron cells and DUOX1 expression, and increase VDR expression.	Vitamin D	0-9	dual oxidase 1	Canis lupus familiaris	63-68
32717927-4	2020	A high concentration of active vitamin D, 1alpha,25(OH)2D3, decreased the expression of myogenic regulatory factors (MRFs), myf5 and myogenin in proliferating myoblasts.	Vitamin D	31-40	myogenic factor 5	Homo sapiens	124-128
32834827-10	2020	The allele C of rs9279 on VDR, was negatively associated with asthma risk (OR = 0.66; 95% CI 0.45-0.97), vitamin D insufficiency (OR = 0.78; 95% CI 0.70-0.96) and higher VDR expression.	Vitamin D	105-114	vitamin D receptor	Homo sapiens	26-29
32834827-12	2020	The combination of variants in CYP2R1 and CYP24A1 (GAC, to rs10500804, rs12794714 and rs3886163, respectively) was negatively associated with vitamin D production (beta = - 1.24; 95% CI - 2.42 to - 0.06).	Vitamin D	142-151	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	42-49
32361296-4	2020	Herein, we present the synthesis of vitamin D compounds, designed on the basis of molecular modeling and docking experiments to the vitamin D receptor, and characterized by the presence of significantly different two side chains attached to C-20.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	132-150
32361296-9	2020	The target vitamin D compounds, displaying significant affinity for a vitamin D receptor, were assessed in vitro for their anti-proliferative activities towards several cell lines.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	70-88
31907821-0	2020	Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women.	Vitamin D	20-29	GC vitamin D binding protein	Homo sapiens	64-89
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	6-15	GC vitamin D binding protein	Homo sapiens	33-37
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	93-111
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	113-116
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	6-15	retinoid X receptor alpha	Homo sapiens	118-143
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	6-15	retinoid X receptor alpha	Homo sapiens	145-149
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	68-77	GC vitamin D binding protein	Homo sapiens	6-31
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	68-77	GC vitamin D binding protein	Homo sapiens	33-37
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	93-111
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	113-116
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	68-77	retinoid X receptor alpha	Homo sapiens	118-143
32670515-3	2020	Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia.	Vitamin D	68-77	retinoid X receptor alpha	Homo sapiens	145-149
32670515-14	2020	VDBP rs4701 variant was associated with osteoporosis in our beta-thalassemia patients on vitamin D supplementation.	Vitamin D	89-98	GC vitamin D binding protein	Homo sapiens	0-4
33583806-7	2020	For the setting off and regulation of particular genes, calcitriol-VDR-RXR complex attach to definite DNA fragments called as vitamin D response elements (VDREs).	Vitamin D	126-135	vitamin D receptor	Homo sapiens	67-70
32626760-1	2020	Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	66-84
32626760-1	2020	Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	86-89
32493333-4	2020	However, little is known about local vitamin D metabolism in the airways and studies examining expression of the vitamin D receptor (VDR), the activating enzyme (CYP27B1) and inactivating enzyme (CYP24A1) of vitamin D in lung tissue of COPD patients are lacking.	Vitamin D	113-122	vitamin D receptor	Homo sapiens	133-136
32493333-9	2020	By contrast, CYP24A1 expression was highly present in lung endothelial cells suggesting that systemic vitamin D can be inactivated before reaching the epithelial compartment and the tissue immune cells.	Vitamin D	102-111	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	13-20
32339669-6	2020	Collectively, these results suggest VDBP to be a potential biomarker and propose a potential mechanism of benefit for vitamin D therapy in CSU.	Vitamin D	118-127	GC vitamin D binding protein	Homo sapiens	36-40
32375123-1	2020	INTRODUCTION: Inactivating mutations in CYP24A1, encoding vitamin D-24-hydroxylase, can lead to an accumulation of active vitamin D metabolites and consequent hypercalcaemia.	Vitamin D	58-67	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	40-47
32478379-2	2020	SUMMARY ANSWER: Women with MTHFR 677TT (homozygous mutation, TT) genotype have significantly lower vitamin D levels, higher homocysteine and natural killer (NK) cell cytotoxicities than those of women with MTHFR 677CC (wild type, CC) and 677CT (heterozygous mutation, CT) genotypes.	Vitamin D	99-108	methylenetetrahydrofolate reductase	Homo sapiens	27-32
32478379-16	2020	WIDER IMPLICATIONS OF THE FINDINGS: The findings attained in this analysis regarding the MTHFR polymorphism and its relationship with vitamin D, homocysteine and NK cytotoxicity may aid in uncovering the underlying etiology and mechanism for RPL.	Vitamin D	134-143	methylenetetrahydrofolate reductase	Homo sapiens	89-94
32194242-2	2020	Vitamin D can impact the function of virtually every cell in the gut by binding to its intracellular receptor (VDR) and subsequently transcribing relevant genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	111-114
32114085-0	2020	IL-15 enhances the capacity of primary human macrophages to control Leishmania braziliensis infection by IL-32/vitamin D dependent and independent pathways.	Vitamin D	111-120	interleukin 15	Homo sapiens	0-5
32485310-2	2022	The biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	148-166
32485310-2	2022	The biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	168-171
32083397-2	2020	Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	23-41
32083397-2	2020	Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-46
32083397-2	2020	Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	107-110
32115644-8	2020	To examine this possibility, we examined the variation pattern in another protein in the vitamin D pathway, the vitamin D binding protein (GC protein).	Vitamin D	89-98	GC vitamin D binding protein	Homo sapiens	112-137
32259445-7	2020	Taken together, these findings contribute to our understanding of Adx recognition in a critical vitamin D-inactivating enzyme and provide broader insight regarding the variability inherent in CYP-Adx interactions.	Vitamin D	96-105	ferredoxin 1	Homo sapiens	66-69
32276660-10	2020	While vitamin D administrations delayed fibrosis of early stages, vitamin D worsen hepatic-fibrosis of late stages of CCl4.	Vitamin D	66-75	chemokine (C-C motif) ligand 4	Mus musculus	118-122
32276660-13	2020	CONCLUSION: Vitamin D alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model due to modulations in vitamin D receptor and calcium.	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	119-137
32647755-6	2020	There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements.	Vitamin D	84-93	fibroblast growth factor 23	Homo sapiens	309-336
32647755-6	2020	There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements.	Vitamin D	84-93	fibroblast growth factor 23	Homo sapiens	338-344
32647755-6	2020	There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements.	Vitamin D	84-93	fibroblast growth factor 23	Homo sapiens	309-336
32647755-6	2020	There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements.	Vitamin D	84-93	fibroblast growth factor 23	Homo sapiens	338-344
32233807-6	2020	Administration of vitamin D to diabetic rats resulted in a decrease of serum glucose, serum ADMA, a decrease of aortic MDA levels, ET-1 and iNOS activity, an increase of aortic SOD activity, NO levels, and cNOS activity.	Vitamin D	18-27	nitric oxide synthase 3	Rattus norvegicus	206-210
32067036-2	2020	Vitamin D receptor is widely distributed in male and female reproductive systems, suggesting that vitamin D is essential for fertility.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	0-18
32029884-8	2020	We then discuss the epidermis and hair follicle, to provide a non-skeletal example of a tissue that expresses VDR that not only makes vitamin D but also can metabolize it to its hormonally active form.	Vitamin D	134-143	vitamin D receptor	Homo sapiens	110-113
32213983-3	2020	We developed an adenoviral vector for human VDR and performed transcriptomic and metabolomic analyses of cultured human hepatocytes upon VDR activation by vitamin D (VitD).	Vitamin D	155-164	vitamin D receptor	Homo sapiens	137-140
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	67-76	cubilin	Homo sapiens	8-15
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	35-40
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	67-76	klotho	Homo sapiens	41-47
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	188-197	cubilin	Homo sapiens	8-15
32204545-7	2020	Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.	Vitamin D	188-197	klotho	Homo sapiens	41-47
32206326-0	2020	Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.	Vitamin D	0-9	sorcin	Homo sapiens	111-114
32206326-2	2020	Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis in Sri Lanka.	Vitamin D	39-48	sorcin	Homo sapiens	85-88
32206326-3	2020	This is the first study in Sri Lanka of such kind conducted to evaluate the serum vitamin D levels among postmenopausal women.	Vitamin D	82-91	sorcin	Homo sapiens	27-30
32138242-3	2020	In Mcoln1-/- mice, we found that a high dose of vitamin D (Vit D; 500,000 IU/kg/day) resulted in increased AMC compared to their wild-type littermates, which was accompanied by significant downregulation of SM22-alpha and upregulation of RUNX2 and osteopontin in the arterial media, indicating a phenotypic switch to osteogenic.	Vitamin D	48-57	vitrin	Mus musculus	59-62
31884304-1	2020	PURPOSE: The aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.	Vitamin D	71-80	thyroid stimulating hormone receptor	Homo sapiens	122-134
31884304-1	2020	PURPOSE: The aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.	Vitamin D	71-80	thyroid stimulating hormone receptor	Homo sapiens	136-140
31884304-1	2020	PURPOSE: The aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.	Vitamin D	71-80	thyroid peroxidase	Homo sapiens	195-198
31884304-1	2020	PURPOSE: The aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.	Vitamin D	82-86	thyroid stimulating hormone receptor	Homo sapiens	122-134
31884304-1	2020	PURPOSE: The aim of this study was to evaluate the association between vitamin D (vitD) and changes in the titers of anti-TSH receptor (TSHR-Abs), antithyroglobulin (Tg-Abs), and antiperoxidase (TPO-Abs) autoantibodies.	Vitamin D	82-86	thyroid stimulating hormone receptor	Homo sapiens	136-140
31884304-7	2020	There was a significant inverse correlation between baseline levels of vitD and baseline titers of Tg-Abs (in group 1 only), Tg-Abs after 12 months (in group 1 only), TPO-Abs after 12 months (in groups 1 and 3), fT4 (in group 4 only), and a significant positive correlation with TPO-Abs (in group 2 only).	Vitamin D	71-75	thyroid peroxidase	Homo sapiens	279-282
31984787-5	2020	Vitamin D receptor (VDR) was found to be highly expressed at the distal region of small intestine, where the vitamin D signaling promotes innate immunity, including the expression of alpha-defensins by Paneth cells, and maintains the intestinal tight junctions.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	0-18
31984787-5	2020	Vitamin D receptor (VDR) was found to be highly expressed at the distal region of small intestine, where the vitamin D signaling promotes innate immunity, including the expression of alpha-defensins by Paneth cells, and maintains the intestinal tight junctions.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	20-23
31377232-2	2020	Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1alpha,25-dihydroxyvitamin D3.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	90-108
31377232-2	2020	Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1alpha,25-dihydroxyvitamin D3.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	110-113
31377232-2	2020	Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1alpha,25-dihydroxyvitamin D3.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	110-113
32174704-2	2020	As Vitamin D metabolism and its receptor activity are important factors in human native immune system against some microorganisms, we hypothesized that VDR gene polymorphisms and concentration of Vitamin D might have effect on incidence of cutaneous leishmaniasis.	Vitamin D	3-12	vitamin D receptor	Homo sapiens	152-155
31682937-13	2020	To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.	Vitamin D	187-196	NPC1 like intracellular cholesterol transporter 1	Mus musculus	13-19
31682937-13	2020	To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.	Vitamin D	187-196	NPC1 like intracellular cholesterol transporter 1	Mus musculus	118-124
31682937-13	2020	To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.	Vitamin D	187-196	NPC1 like intracellular cholesterol transporter 1	Mus musculus	13-19
31682937-13	2020	To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.	Vitamin D	187-196	NPC1 like intracellular cholesterol transporter 1	Mus musculus	118-124
31705962-3	2020	Vitamin D deficiency resulted in reduced levels of phosphorylated mTOR, and suppressed mTOR-dependent phosphorylation of 4E-BP1 and p70-S6K, implying a decrease in activity of the protein synthesis machinery.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	66-70
31705962-3	2020	Vitamin D deficiency resulted in reduced levels of phosphorylated mTOR, and suppressed mTOR-dependent phosphorylation of 4E-BP1 and p70-S6K, implying a decrease in activity of the protein synthesis machinery.	Vitamin D	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	87-91
31734492-13	2020	CONCLUSIONS: Our data confirms that vitamin D is present in the humours of the human eye and that local synthesis/degradation is possible via the ocular CYP27B1 and CYP24A1.	Vitamin D	36-45	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	165-172
31838171-7	2020	In addition, we found that CRMP2 was associated with NR2B and PSD-95 in 3xTg-AD mice with vitamin D supplementation.	Vitamin D	90-99	discs large MAGUK scaffold protein 4	Mus musculus	62-68
32863248-4	2020	The aim of this study is to compare the effects of serum vitamin D on serum IL 17 and pulmonary function test (FVC, FEV1, FEV1/FVC) before and after oral vitamin D supplementation.	Vitamin D	57-66	interleukin 17A	Homo sapiens	76-81
32056782-1	2020	INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	77-80
32056782-1	2020	INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	77-80
31924508-1	2020	The aim of this study was to demonstrate the effects of vitamin D treatment on ultrastructural changes and AMHR2 expression in the ovary in PCOS rat model.	Vitamin D	56-65	anti-Mullerian hormone receptor type 2	Rattus norvegicus	107-112
32049468-4	2020	In addition to the well-known role of vitamin D in calcium and phosphate homeostasis, the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (calcitriol), exerts potent effects on cellular differentiation and regulation of immune responses via binding to the vitamin D receptor present in most cells of the immune system.	Vitamin D	108-117	vitamin D receptor	Homo sapiens	273-291
32051922-2	2020	It is widely recognized that the vitamin D receptor (VDR) and the enzymes that metabolize vitamin D are found in many cells, not just those involved with calcium and phosphate homeostasis.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
31651575-5	2020	In secondary analyses, we assessed for evidence that the effect of Vitamin D on post-MVC pain outcomes is mediated, at least in part, by the influence of Vitamin D on genetic variants in genes involved in immune system regulation (IL-10 and NLRP3).	Vitamin D	67-76	interleukin 10	Homo sapiens	231-236
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	dual oxidase 1	Mus musculus	223-228
31756344-8	2020	RESULTS: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARalpha, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.	Vitamin D	39-48	anterior capsular cataract	Mus musculus	237-240
32918214-6	2020	It seems probable that other factors such as ethnicity, phenotype, 25(OH)D plasma levels, and UV radiation exposure play a role as confounding factors and introduce heterogeneity.To conclude, there is some indication that VDR polymorphisms may modulate the risk of some cancer sites and in future studies VDR genetic variation should be integrated also with assessment of vitamin D status and stratified by ethnicity.	Vitamin D	372-381	vitamin D receptor	Homo sapiens	222-225
32918222-4	2020	The hormone derived from vitamin D, calcitriol (1,25-dihydroxyvitamin D3) and other related compounds, working via the vitamin D receptor and at least in part through endoplasmic reticulum protein 57 (ERp57), reduce cyclobutane pyrimidine dimers and oxidative DNA damage in keratinocytes and other skin cell types after UV.	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	119-137
32918224-5	2020	These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	187-205
32918224-5	2020	These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR).	Vitamin D	29-38	vitamin D receptor	Homo sapiens	207-210
32918224-5	2020	These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR).	Vitamin D	89-98	vitamin D receptor	Homo sapiens	187-205
32918224-5	2020	These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR).	Vitamin D	89-98	vitamin D receptor	Homo sapiens	207-210
32918224-9	2020	They are inhibition of proliferation/stimulation of differentiation with discussion of the roles of hedgehog, Wnt/beta-catenin, and hyaluronan/CD44 pathways in mediating vitamin D regulation of proliferation/differentiation, regulation of the balance between oncogenic and tumor suppressor long noncoding RNAs, immune regulation, and promotion of DNA damage repair (DDR).	Vitamin D	170-179	CD44 molecule (Indian blood group)	Homo sapiens	143-147
31837111-6	2020	RESULTS: Administration of VitD promotes the proliferation and differentiation of neural stem cells in the subventricular zone and the migration of these cells to the lesion site in the corpus callosum; these cells subsequently differentiate into oligodendrocyte lineage cells and produce myelin basic protein.	Vitamin D	27-31	myelin basic protein	Rattus norvegicus	289-309
31837111-8	2020	Megalin expression did not increase at the lesion site, which suggests that VitD is internalized by other mechanisms.	Vitamin D	76-80	LDL receptor related protein 2	Rattus norvegicus	0-7
31696340-2	2020	CYP24A1 is the key enzyme for metabolic inactivation of active VD (1,25(OH)2D3).	Vitamin D	63-65	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
31758181-1	2020	Fibroblast growth factor-23 (FGF23) is critical for phosphate and vitamin D homeostasis.	Vitamin D	66-75	fibroblast growth factor 23	Mus musculus	0-27
31758181-1	2020	Fibroblast growth factor-23 (FGF23) is critical for phosphate and vitamin D homeostasis.	Vitamin D	66-75	fibroblast growth factor 23	Mus musculus	29-34
32238143-7	2020	The immunmodulatory effects of the active metabolite of vitamin D (alpha-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF-beta and s-CTLA-4 was assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC.	Vitamin D	56-65	interleukin 10	Homo sapiens	116-121
32528735-4	2020	Noting that vitamin D deficiency decreases SCD in the periphery, we propose it also decreases SCD in oligodendrocytes, disrupting the nervonic acid supply and causing myelin instability and fragmentation.	Vitamin D	12-21	stearoyl-CoA desaturase	Homo sapiens	43-46
32405353-0	2020	Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats.	Vitamin D	10-19	brain-derived neurotrophic factor	Rattus norvegicus	49-53
32405353-10	2020	Results: Administration of vitamin D (4300 IU/kg/week) in a T1DM animal model increased CREB phosphorylation in the hippocampus, but the serum and hippocampal BDNF levels and TrkB and BDNF gene expression did not change significantly.	Vitamin D	27-36	brain-derived neurotrophic factor	Rattus norvegicus	159-163
32405353-10	2020	Results: Administration of vitamin D (4300 IU/kg/week) in a T1DM animal model increased CREB phosphorylation in the hippocampus, but the serum and hippocampal BDNF levels and TrkB and BDNF gene expression did not change significantly.	Vitamin D	27-36	brain-derived neurotrophic factor	Rattus norvegicus	184-188
31704050-1	2020	OBJECTIVES: To investigate the effect of oral vitamin D-calcium supplementation on serum intact parathyroid hormone (PTH), calcium, phosphorous, and alkaline phosphatase (ALK-P) concentrations in children with habitually low calcium intakes.	Vitamin D	46-55	ALK receptor tyrosine kinase	Homo sapiens	171-174
31918428-2	2020	CYP24A1 regulates vitamin D activity and is closely linked to hypertension.	Vitamin D	18-27	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
31691146-15	2020	The treated groups, especially combined vitamin D and exercise group, showed a significant decrease in IL-6, MDA, amyloid beta and tau proteins levels, but on the other hand they showed a significant increase in IL-10, GSH, AChE, dopamine, BDNF and NGF.	Vitamin D	40-49	brain-derived neurotrophic factor	Rattus norvegicus	240-244
32219739-8	2020	Another important dimension to be considered in the study of vitamin D and muscle fiber metabolism is associated with different expressions of the vitamin D receptor, which differs in muscle tissue, depending on age, gender, and pathology.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	147-165
33601398-0	2020	Vitamin D Alleviates Cognitive Dysfunction by Activating the VDR/ERK1/2 Signaling Pathway in an Alzheimer"s Disease Mouse Model.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	61-64
32289634-2	2020	The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation.	Vitamin D	100-109	7-dehydrocholesterol reductase	Homo sapiens	129-134
32289634-2	2020	The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation.	Vitamin D	100-109	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-153
32289634-2	2020	The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	165-168
31892349-0	2019	Association between vitamin D plasma concentrations and VDR gene variants and the risk of premature birth.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	56-59
31892349-2	2019	The effects of vitamin D are mediated by its receptor, which is encoded by the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	79-82
31892349-13	2019	CONCLUSIONS: VDR variants contribute to variations in vitamin D concentrations and the increased risk of prematurity.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	13-16
32121673-0	2019	Vitamin D deficiency among children aged 10-18 years in Sri Lanka Background: Vitamin D deficiency (VDD) and insufficiency (VDI) are public health problems in many countries, and limited data is available on the prevalence of VDD/VDI in Sri Lanka.	Vitamin D	0-9	sorcin	Homo sapiens	56-59
31949415-12	2019	The increase of serum hepcidin levels may be inhibited by effective treatment of anemia with iron supplementation and erythropoietin, and the treatment of secondary hyperparathyroidism with phosphate binders and the active form of vitamin D, which decrease serum parathyroid hormone and fibroblast growth factor-23 levels, and control inflammation to some extent.	Vitamin D	231-240	fibroblast growth factor 23	Homo sapiens	287-314
31877961-7	2019	On molecular level, the WD reduced proliferation (p < 0.05) and increased expression of the vitamin D catabolizing enzyme Cyp24a1 (p < 0.001).	Vitamin D	92-101	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	122-129
31618573-2	2019	In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	133-136
31618573-2	2019	In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	163-166
31618573-2	2019	In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	163-166
31833904-13	2019	CONCLUSIONS: Vitamin D supplementation had no beneficial effect on anti-TB treatment, but it reduced the time to sputum culture conversion in participants with tt genotype of the TaqI vitamin D receptor gene polymorphism and improved the MDR TB sputum culture conversion rate.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	184-202
31823791-0	2019	OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D.	Vitamin D	99-108	TNF superfamily member 11	Homo sapiens	9-14
31819048-0	2019	Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3.	Vitamin D	0-9	lipocalin 2	Homo sapiens	91-95
31819048-0	2019	Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3.	Vitamin D	0-9	ribosomal protein S3	Homo sapiens	143-147
31819048-7	2019	Cisplatin enhanced the expression of LCN2 by decreasing methylation at the promoter, whereas vitamin D enhanced methylation and thereby inhibited the expression of LCN2.	Vitamin D	93-102	lipocalin 2	Homo sapiens	164-168
31905439-6	2019	Excessive action of fibroblast growth factor 23 (FGF23), a key regulator of Pi metabolism, leads to renal Pi wasting and impairs vitamin D activation.	Vitamin D	129-138	fibroblast growth factor 23	Homo sapiens	20-47
31905439-6	2019	Excessive action of fibroblast growth factor 23 (FGF23), a key regulator of Pi metabolism, leads to renal Pi wasting and impairs vitamin D activation.	Vitamin D	129-138	fibroblast growth factor 23	Homo sapiens	49-54
31112659-0	2019	Associations of CYP24A1 copy number variation with vitamin D deficiency and insulin secretion.	Vitamin D	51-60	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	16-23
31112659-2	2019	As the enzyme that initiates degradation of the active metabolite of vitamin D (1,25-(OH)2 vitamin D), 24-hydroxylase encoded by CYP24A1 may be associated with insulin secretion.	Vitamin D	69-78	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	91-117
31112659-2	2019	As the enzyme that initiates degradation of the active metabolite of vitamin D (1,25-(OH)2 vitamin D), 24-hydroxylase encoded by CYP24A1 may be associated with insulin secretion.	Vitamin D	69-78	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	129-136
31112659-6	2019	Association between copy number of CYP24A1 and vitamin D deficiency was investigated with logistic regression model.	Vitamin D	47-56	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	35-42
31112659-8	2019	The results suggested that copy number variation of CYP24A1 was associated with vitamin D deficiency.	Vitamin D	80-89	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	52-59
31112659-9	2019	Higher copy number of CYP24A1 was a risk factor for vitamin D deficiency (adjusted odds ratio: 1.199; 95% confidence interval: 1.028-1.397; P = 0.021).	Vitamin D	52-61	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	22-29
31112659-10	2019	Furthermore, copy number of CYP24A1 was positive correlated with the concentration of serum insulin (r = 0.115; P < 0.001), regardless of vitamin D status, age, and body mass index (BMI).	Vitamin D	138-147	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	28-35
31112659-11	2019	Increased copy number of CYP24A1 is associated with not only vitamin D deficiency but also increased serum insulin.	Vitamin D	61-70	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	25-32
31112659-12	2019	Vitamin D supplement may be beneficial to individuals with high copy number of CYP24A1.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	79-86
31112659-13	2019	Novelty Increased copy number of CYP24A1 was a risk factor of vitamin D deficiency.	Vitamin D	62-71	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	33-40
31112659-14	2019	Increased copy number of CYP24A1 was associated with increased serum concentration of insulin independent of age, BMI, and vitamin D status.	Vitamin D	123-132	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	25-32
31725784-5	2019	The mineral absorption pathway genes, HMOX1 and VDR are involved in iron metabolism and response to vitamin D, respectively.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	48-51
31867158-6	2019	Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription.	Vitamin D	157-166	vitamin D receptor	Homo sapiens	10-13
31867158-6	2019	Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription.	Vitamin D	157-166	retinoid X receptor alpha	Homo sapiens	39-64
31867158-6	2019	Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription.	Vitamin D	157-166	retinoid X receptor alpha	Homo sapiens	66-74
31570180-0	2019	Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement.	Vitamin D	74-83	interleukin 17A	Homo sapiens	19-25
31570180-0	2019	Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement.	Vitamin D	74-83	interleukin 10	Homo sapiens	26-31
31570180-4	2019	This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation.	Vitamin D	100-105	interleukin 17A	Homo sapiens	43-49
31570180-4	2019	This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation.	Vitamin D	100-105	interleukin 10	Homo sapiens	54-59
31570180-12	2019	Vit D supplementation reduces the serum IL-17A levels and elevates the serum IL-10 levels in persistent asthmatic patients.	Vitamin D	0-5	interleukin 17A	Homo sapiens	40-46
31570180-12	2019	Vit D supplementation reduces the serum IL-17A levels and elevates the serum IL-10 levels in persistent asthmatic patients.	Vitamin D	0-5	interleukin 10	Homo sapiens	77-82
31570180-14	2019	The IL-17A/IL-10 ratio seems to be a possible predictive biomarker for asthma improvement in patients depending on Vit D supplementation.	Vitamin D	115-120	interleukin 17A	Homo sapiens	4-10
31570180-14	2019	The IL-17A/IL-10 ratio seems to be a possible predictive biomarker for asthma improvement in patients depending on Vit D supplementation.	Vitamin D	115-120	interleukin 10	Homo sapiens	11-16
30829137-1	2019	The present randomized, double-blind, placebo controlled study aimed to evaluate the effect of vitamin D supplementation on matrix metalloproteinases-2, -9 (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in subjects with metabolic syndrome.	Vitamin D	95-104	matrix metallopeptidase 9	Homo sapiens	167-172
31173353-9	2019	CONCLUSIONS: Vitamin D might contribute in reducing diabetic cardiomyopathy not only by improving blood glucose and insulin levels but also via downregulating AGE and hexosamine pathways and decreasing NF-kB activity in heart tissue.	Vitamin D	13-22	renin binding protein	Rattus norvegicus	159-162
31365099-1	2019	CONTEXT: Single nucleotide polymorphisms (SNPs) of the vitamin D binding protein encoding GC (group component) gene affect 25-hydroxyvitamin D (25OHD) concentrations but their influence on vitamin D status and response to vitamin D supplementation in infants is unknown.	Vitamin D	133-142	GC vitamin D binding protein	Homo sapiens	55-80
31372708-0	2019	Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis.	Vitamin D	5-14	fibroblast growth factor 23	Homo sapiens	48-75
31372708-1	2019	Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies.	Vitamin D	28-37	fibroblast growth factor 23	Homo sapiens	73-100
31372708-1	2019	Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies.	Vitamin D	28-37	fibroblast growth factor 23	Homo sapiens	102-107
31372708-1	2019	Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies.	Vitamin D	115-124	fibroblast growth factor 23	Homo sapiens	73-100
31372708-1	2019	Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies.	Vitamin D	115-124	fibroblast growth factor 23	Homo sapiens	102-107
31372708-8	2019	The meta-analyses found that serum intact FGF23 increased significantly after oral vitamin D3 supplementation in vitamin D-deficient participants with the pooled SMD of 0.36 (95%CI, 0.14, 0.57; p = 0.001; I2 of 36%).	Vitamin D	83-92	fibroblast growth factor 23	Homo sapiens	42-47
31372708-9	2019	Serum C-terminal FGF23 also increased after vitamin D3 supplementation in vitamin D-deficient participants with the pooled SMD of 0.28 although without reaching statistical significance (95%CI, - 0.08, 0.65; p = 0.13; I2 of 0%).	Vitamin D	44-53	fibroblast growth factor 23	Homo sapiens	17-22
31372708-11	2019	Vitamin D supplementation leads to a significant increase in serum intact FGF23 among vitamin D-deficient patients.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	74-79
31372708-11	2019	Vitamin D supplementation leads to a significant increase in serum intact FGF23 among vitamin D-deficient patients.	Vitamin D	86-95	fibroblast growth factor 23	Homo sapiens	74-79
31372708-13	2019	The present systematic review and meta-analysis revealed that serum intact FGF23 concentration increased significantly after oral vitamin D3 supplementation in vitamin D-deficient participants.	Vitamin D	130-139	fibroblast growth factor 23	Homo sapiens	75-80
30712059-0	2019	Vitamin D binding protein polymorphisms significantly impact vitamin D status in children.	Vitamin D	61-70	GC vitamin D binding protein	Homo sapiens	0-25
30712059-1	2019	BACKGROUND: Polymorphic alleles of the vitamin D (vitD)-binding protein (VDBP) gene are associated with discriminatory differences in circulating concentrations of 25-hydroxyvitamin D (25-D), the indicator of vitD status (sufficiency defined by the Endocrine Society as &gt;=75 nmol/L).	Vitamin D	39-48	GC vitamin D binding protein	Homo sapiens	73-77
31719947-6	2019	Logistic regression analyses were performed to detect an association between allergic asthma status and the interaction of the VDR SNP and serum vitamin D concentration in the case-control samples.	Vitamin D	145-154	vitamin D receptor	Homo sapiens	127-130
31673295-6	2019	Results: This study results demonstrated that vitamin D supplementation could down-regulate RAGE mRNA [fold change = 0.72 in vitamin D vs. 0.95 in placebo) P = 0.001)].	Vitamin D	46-55	long intergenic non-protein coding RNA 914	Homo sapiens	92-96
31673295-6	2019	Results: This study results demonstrated that vitamin D supplementation could down-regulate RAGE mRNA [fold change = 0.72 in vitamin D vs. 0.95 in placebo) P = 0.001)].	Vitamin D	125-134	long intergenic non-protein coding RNA 914	Homo sapiens	92-96
31673295-10	2019	Conclusion: In conclusion, vascular complications are more frequent in diabetic patients, and vitamin D treatment may prevent or delay the complications onset in these patients by AGEs serum level and RAGE gene expression reducing.Trial registration NCT03008057.	Vitamin D	94-103	long intergenic non-protein coding RNA 914	Homo sapiens	201-205
31188746-1	2019	Loss of function mutations in the CYP24A1 gene, involved in vitamin D catabolism and in calcium homeostasis, are known to be the genetic drivers of both idiopathic infantile hypercalcemia (IIH) and adult renal stone disease.	Vitamin D	60-69	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	34-41
31777705-0	2019	Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind randomized clinical trial.	Vitamin D	10-19	sirtuin 1	Homo sapiens	94-103
31640823-1	2020	Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	107-110
31640823-1	2020	Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory.	Vitamin D	90-95	vitamin D receptor	Homo sapiens	107-110
31640823-1	2020	Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory.	Vitamin D	90-95	vitamin D receptor	Homo sapiens	107-110
31649297-0	2019	Association of Fok1 VDR polymorphism with Vitamin D and its associated molecules in pulmonary tuberculosis patients and their household contacts.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	20-23
31640710-1	2019	BACKGROUND: Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease.	Vitamin D	36-45	GC vitamin D binding protein	Homo sapiens	77-102
31681485-0	2019	Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-alpha.	Vitamin D	0-9	matrix metallopeptidase 9	Homo sapiens	73-78
31681485-13	2019	Vitamin D reduced the production of MMP-9 and attenuated the breakdown of ECJs in the HGKs treated with TNF-alpha.	Vitamin D	0-9	matrix metallopeptidase 9	Homo sapiens	36-41
31681485-16	2019	Conclusions: These results suggest that vitamin D may avert TNF-alpha-induced downregulation of the development of ECJs in HGKs by decreasing the production of MMP-9, which was upregulated by TNF-alpha.	Vitamin D	40-49	matrix metallopeptidase 9	Homo sapiens	160-165
31624297-5	2019	In vitamin D group, serum levels of IL-10 and IL-12 significantly decreased while TAC significantly increased post-intervention.	Vitamin D	3-12	interleukin 10	Homo sapiens	36-41
32337495-8	2020	Conclusions: Our results suggest that the 25(OH)D-CRC association may differ by DBP isoform, and those with a DBP2-encoding genotype linked to vitamin D insufficiency may particularly benefit from adequate 25(OH)D for CRC prevention.	Vitamin D	143-152	DEAH-box helicase 16	Homo sapiens	110-114
31582399-4	2019	RESULTS: Vitamin D enhanced in vitro IFN responses, as measured by induction of p-Y-STAT1 and MxA in MNCs, T cells, and monocytes.	Vitamin D	9-18	signal transducer and activator of transcription 1	Homo sapiens	84-89
31582399-6	2019	The combination of vitamin D plus IFN-beta reduced Th1 and Th17 cytokines, and increased Th2 responses, reversing the effect of IFN-beta alone.	Vitamin D	19-28	negative elongation factor complex member C/D	Homo sapiens	51-54
31250032-0	2019	Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases.	Vitamin D	25-34	advanced glycosylation end-product specific receptor	Homo sapiens	42-46
31408845-13	2019	Total vitamin D was positively correlated with Matsuda-index (p=0.002), VDBP (p=0.045), and negatively with BMI SDS (p=0.043), HOMA-IR (p=0.008), HOMA-B (p=0.001), IGI (p=0.007), Derivative Control (p=0.036) and Proportional Control (p=0.018).	Vitamin D	6-15	GC vitamin D binding protein	Homo sapiens	72-76
31465769-3	2019	These vitamin D-derived metabolites signal through the vitamin D receptor (VDR).	Vitamin D	6-15	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	55-73
31465769-3	2019	These vitamin D-derived metabolites signal through the vitamin D receptor (VDR).	Vitamin D	6-15	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	75-78
31465769-15	2019	These vitamin D metabolites appear to signal through both VDR-dependent and -independent pathways.	Vitamin D	6-15	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-61
31495905-7	2019	FGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calcium, vitamin D, and parathyroid hormone that are important for bone health and systemic mineral balance.	Vitamin D	105-114	fibroblast growth factor 23	Homo sapiens	0-5
31115927-1	2019	Vitamin D (Vit D) increases calcium absorption in the intestine after binding to the Vit D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	85-99
31115927-1	2019	Vitamin D (Vit D) increases calcium absorption in the intestine after binding to the Vit D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	101-104
31255688-14	2019	Higher levels of Vitamin D along with VDR and iNOS expression in household contacts as compared to active TB patients suggest vitamin D might have a protective role against TB plausibly decreasing disease susceptibility.	Vitamin D	126-135	vitamin D receptor	Homo sapiens	38-41
31352041-12	2019	Our data showing suppression by glucocorticoids on CYP24A1 expression in human osteoblasts suggest a previously unknown mechanism for effects of glucocorticoids in human bone, where these compounds may interfere with regulation of active vitamin D levels.	Vitamin D	238-247	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	51-58
31278171-1	2019	INTRODUCTION: Vitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1alpha-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	97-115
31126722-9	2019	AD and/or psychosis-related genes were enriched in the list of genes most perturbed by vitamin D, specifically genes involved in the regulation of calcium signaling downstream of the vitamin D receptor.	Vitamin D	87-96	vitamin D receptor	Homo sapiens	183-201
31272909-2	2019	It is suggested that antitumour effect of vitamin D depends on vitamin D-receptor (VDR) expression.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	63-81
31272909-2	2019	It is suggested that antitumour effect of vitamin D depends on vitamin D-receptor (VDR) expression.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	83-86
31261027-10	2019	However, Overexpression of VDR and vitamin D treatment could induce the cell survival and alleviate the FoxO1-induced cell apoptosis, furthermore, vitamin D treatment or silencing of FoxO1 gene could reverse the ROS-induced cell apoptosis.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	27-30
31891001-2	2019	CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity.	Vitamin D	17-26	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
31891001-2	2019	CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity.	Vitamin D	86-95	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
31891001-11	2019	Conclusion: Lower VDMR, a measure of CYP24A1-mediated vitamin D clearance, was significantly associated with all-cause mortality but not with progression to ESRD in patients with CKD.	Vitamin D	54-63	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	37-44
31455010-0	2019	Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D.	Vitamin D	103-112	vitamin D receptor	Homo sapiens	26-29
31534663-8	2019	Vitamin D was also inversely related to TSH, HOMA-IR, and levels of anti-TG and anti-TPO.	Vitamin D	0-9	thyroid peroxidase	Homo sapiens	85-88
31534963-0	2019	Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	60-78
31534963-2	2019	The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	95-113
31534963-2	2019	The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	115-118
31534963-4	2019	The aim of the current study was to assess the relationship between serum vitamin D metabolite and calcium levels with VDR polymorphisms in normal and colorectal cancer (CRC) patients.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	119-122
31534963-7	2019	Results: The homozygous genotype (aa) of the ApaI VDR polymorphism (rs7975232) was found to correlate with total serum vitamin D levels of CRC patients, while the heterozygous (Tt) TaqI VDR polymorphism (rs731236) was associated with serum calcium levels.	Vitamin D	119-128	vitamin D receptor	Homo sapiens	50-53
31431821-6	2019	Highly expressed miR-155 has been downregulated by flavonoids (through a quercetin-rich diet) and by vitamin D.	Vitamin D	101-110	microRNA 155	Homo sapiens	17-24
31555688-8	2019	Results: Association of the VDBP (rs4588) T/T genotype with CAD patients after acute MI and correlation of VDBP (rs4588) genotype G/G with higher levels of total vitamin D were found.	Vitamin D	162-171	GC vitamin D binding protein	Homo sapiens	107-111
30922121-0	2019	Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin.	Vitamin D	21-30	retinoic acid receptor responder 2	Rattus norvegicus	105-113
31044263-3	2019	INTRODUCTION: Fibroblast growth factor 23 (FGF23) is an endocrine hormone-regulating phosphate and vitamin D metabolism.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	14-41
31044263-3	2019	INTRODUCTION: Fibroblast growth factor 23 (FGF23) is an endocrine hormone-regulating phosphate and vitamin D metabolism.	Vitamin D	99-108	fibroblast growth factor 23	Homo sapiens	43-48
31044263-10	2019	CONCLUSIONS: Taken together, high FGF23 levels are associated with impaired trabecular bone microarchitecture in osteoporosis patients, and this association seems to occur after adjustment of confounding variables including phosphate and vitamin D.	Vitamin D	238-247	fibroblast growth factor 23	Homo sapiens	34-39
31477207-3	2019	Vitamin D deficiency reduced the expression of the glucocorticoid-inactivating enzyme Hsd11b2 in the female placenta, but did not alter maternal glucocorticoid levels, feto-placental weights, or placental expression of other glucocorticoid-related genes at mid-gestation.	Vitamin D	0-9	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	86-93
31252402-6	2019	RNA-sequencing revealed a Vitamin D dose-response gene signature enriched with a higher number of VDR-responsive elements (VDREs) per gene.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	98-101
31358030-3	2019	Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-61
31358030-3	2019	Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	63-66
31358030-3	2019	Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	142-145
31357732-3	2019	Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D.	Vitamin D	167-176	7-dehydrocholesterol reductase	Homo sapiens	79-84
31357732-3	2019	Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D.	Vitamin D	167-176	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-152
31357732-3	2019	Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D.	Vitamin D	219-228	7-dehydrocholesterol reductase	Homo sapiens	79-84
31357732-3	2019	Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D.	Vitamin D	219-228	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-152
31357732-8	2019	These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels.	Vitamin D	152-161	7-dehydrocholesterol reductase	Homo sapiens	28-33
31386628-2	2019	Hypomorphic mutant Klotho [kl/kl] mice on C57BL/6xC3H, BALB/c and 129 genetic backgrounds, show decreased Klotho expression that correlate with accelerated aging including pre-mature death due to abnormally high levels of serum vitamin D.	Vitamin D	228-237	klotho	Mus musculus	19-25
31497480-0	2019	Profound vitamin D deficiency in four siblings with Imerslund-Grasbeck syndrome with homozygous CUBN mutation.	Vitamin D	9-18	cubilin	Homo sapiens	96-100
31497480-13	2019	Low vitamin D could be explained by cubilin being involved in reabsorption of vitamin carriers.	Vitamin D	4-13	cubilin	Homo sapiens	36-43
31363484-17	2019	Conclusion: We report a series of diabetic and hypertensive retinopathy cases with MTHFR polymorphisms and the improvement of retinal microvasculature (mainly MAs) in serial fundus photography after taking a medical food or supplement containing L-methylfolate and vitamin D.	Vitamin D	265-274	methylenetetrahydrofolate reductase	Homo sapiens	83-88
31330869-0	2019	Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro.	Vitamin D	0-9	TANK binding kinase 1	Sus scrofa	94-98
31379807-5	2019	Using rheumatoid arthritis (RA) as a model of autoimmune disease, we here demonstrate that pro-inflammatory memory CCR6+ Th cells can switch into anti-inflammatory cells with regulatory capacity using the active vitamin D metabolite 1,25(OH)2D3.	Vitamin D	212-221	C-C motif chemokine receptor 6	Homo sapiens	115-119
31292298-0	2019	Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.	Vitamin D	0-9	sclerostin	Mus musculus	31-41
31295336-8	2019	Association of AmB/LE and vitamin D deficiency led to diminished glomerular filtration rate and increased tubular injury, evidenced by reduced renal protein expression of NaPi-IIa and TRPM6 leading to hyperphosphaturia / hypermagnesuria.	Vitamin D	26-35	transient receptor potential cation channel, subfamily M, member 6	Rattus norvegicus	184-189
31360166-0	2019	Maternal Vitamin D Status and Its Effect on Vitamin D Levels in Early Infancy in a Tertiary Care Centre in Sri Lanka.	Vitamin D	9-18	sorcin	Homo sapiens	107-110
31360166-2	2019	However, there is very little information on vitamin D levels, especially in the vulnerable populations (pregnant/breast feeding mother and infants) in Sri Lanka.	Vitamin D	45-54	sorcin	Homo sapiens	152-155
31360166-5	2019	The purpose of this study was to investigate maternal vitamin D status and its effects on infants in a state sector tertiary care centre in Sri Lanka.	Vitamin D	54-63	sorcin	Homo sapiens	140-143
30929318-4	2019	OBJECTIVES: The aim of this study was to investigate the association of the TaqI polymorphism (rs731236, c.1056T &gt;C) in the VDR gene with serum vitamin D concentration and bone mineral density (BMD) in patients with IBD.	Vitamin D	147-156	vitamin D receptor	Homo sapiens	127-130
31070844-1	2019	OBJECTIVES: This study evaluated the associations between single-nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, maternal vitamin D concentration, and gestational outcomes.	Vitamin D	104-113	vitamin D receptor	Homo sapiens	124-127
31070844-9	2019	CONCLUSIONS: The VDR gene is an important genetic predictor of a higher concentration of vitamin D during gestation, low birth weight, and decreasing duration of gestation.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	17-20
31587692-0	2019	Vitamin D increases the production of IL-10 by regulatory T cells in patients with systemic sclerosis.	Vitamin D	0-9	interleukin 10	Homo sapiens	38-43
31141481-1	2019	Background Vitamin D resistant rickets (HVDRR), is a rare autosomal recessive disorder caused by vitamin D receptor (VDR) gene mutations.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	97-115
31141481-1	2019	Background Vitamin D resistant rickets (HVDRR), is a rare autosomal recessive disorder caused by vitamin D receptor (VDR) gene mutations.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
31281179-9	2019	At the molecular levels, administration of vitamin D activated the expression of VDR and reduced the number of dead cells in the CA1 region of the hippocampus as well as regulated caspase-3 and Bcl-2 expression.	Vitamin D	43-52	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	81-84
31281179-9	2019	At the molecular levels, administration of vitamin D activated the expression of VDR and reduced the number of dead cells in the CA1 region of the hippocampus as well as regulated caspase-3 and Bcl-2 expression.	Vitamin D	43-52	caspase 3	Mus musculus	180-189
31244851-0	2019	Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer.	Vitamin D	0-9	CD8a molecule	Homo sapiens	36-39
31244851-5	2019	Immunomonitoring of the different immune subsets in dissociated tumors revealed an increase in tumor infiltrating CD8+ T cells in the vitamin D-treated group.	Vitamin D	134-143	CD8a molecule	Homo sapiens	114-117
31244851-7	2019	However, in high-fat diet conditions, we observed an opposite effect of vitamin D on breast cancer tumor growth, associated with a reduction of CD8+ T cell infiltration.	Vitamin D	72-81	CD8a molecule	Homo sapiens	144-147
30923017-11	2019	In conclusion, we suggest that both VDR and CaSR might be useful as molecular markers for predicting treatment outcomes and identifying the CRC patient subgroups who might benefit from 5-FU-based chemotherapy combined with vitamin D analog.	Vitamin D	223-232	vitamin D receptor	Homo sapiens	36-39
30685787-8	2019	I/R injury affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression.	Vitamin D	67-76	fibroblast growth factor 23	Mus musculus	24-51
30685787-8	2019	I/R injury affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression.	Vitamin D	67-76	fibroblast growth factor 23	Mus musculus	53-58
30685787-8	2019	I/R injury affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression.	Vitamin D	67-76	fibroblast growth factor 23	Mus musculus	113-118
31156695-1	2019	Background: Vitamin-D binding protein (DBP) also known as GC protein, is a major determinant for vitamin- D metabolism and transport.	Vitamin D	97-107	GC vitamin D binding protein	Homo sapiens	12-37
31156695-1	2019	Background: Vitamin-D binding protein (DBP) also known as GC protein, is a major determinant for vitamin- D metabolism and transport.	Vitamin D	97-107	GC vitamin D binding protein	Homo sapiens	39-42
31134092-5	2019	The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	243-246
31134092-5	2019	The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway.	Vitamin D	149-158	vitamin D receptor	Homo sapiens	243-246
31115209-11	2019	Vitamin D levels increased significantly within 5 weeks in the Poly-Nac group (26.6 +- 8.8 ng/mL; p = 0.001) compared to the sham group (3.1 +- 0.9 ng/mL), and the Poly-Nac group to the ImmunoD group (7.0 +- 3.6 ng/mL; p = 0.003).	Vitamin D	0-9	NLR family, pyrin domain containing 1A	Mus musculus	68-71
31115209-11	2019	Vitamin D levels increased significantly within 5 weeks in the Poly-Nac group (26.6 +- 8.8 ng/mL; p = 0.001) compared to the sham group (3.1 +- 0.9 ng/mL), and the Poly-Nac group to the ImmunoD group (7.0 +- 3.6 ng/mL; p = 0.003).	Vitamin D	0-9	NLR family, pyrin domain containing 1A	Mus musculus	169-172
30988721-13	2019	Vitamin D can effectively treat Crohn"s disease, which may improve the chemotaxis and differentiation of Th1 cells by inhibiting IL-17/IL-17R pathway, thereby improving immune function and reducing the severity of disease.	Vitamin D	0-9	interleukin 17 receptor A	Rattus norvegicus	135-141
30478987-0	2019	Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy.	Vitamin D	7-16	signal transducer and activator of transcription 1	Homo sapiens	63-69
30478987-2	2019	This study aimed to investigate whether active vitamin D (VD) suppresses macrophage transition to the M1 phenotype via inhibiting the high glucose-induced STAT-1 phosphorylation to reduce TREM-1 expression.	Vitamin D	47-56	signal transducer and activator of transcription 1	Homo sapiens	155-161
30944611-4	2019	The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR).	Vitamin D	32-41	vitamin D receptor	Homo sapiens	111-129
30944611-4	2019	The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR).	Vitamin D	32-41	vitamin D receptor	Homo sapiens	131-134
31099881-1	2019	The authors" main objective was to demonstrate the confounding effect of combining subgroup data, specifically race, on the prevalence of vitamin D deficiency in adolescent idiopathic scoliosis (AIS).	Vitamin D	138-147	IS1	Homo sapiens	195-198
31099881-5	2019	Vitamin D status in girls with AIS was also compared with that in girls without AIS who had a history of fracture and with the medical literature to determine if deficiency in AIS was equal to or greater than other cohorts.	Vitamin D	0-9	IS1	Homo sapiens	31-34
31039170-1	2019	BACKGROUND: Vitamin D may play a role in skeletal muscle because of the discovery of VDR in skeletal muscle.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	85-88
31035488-1	2019	BACKGROUND: Epidemiological studies have suggested a survival benefit for hemodialysis patients on paricalcitol or calcitriol, but nutritional vitamin D supplementation of patients already on vitamin D receptor (VDR) activators is controversial.	Vitamin D	143-152	vitamin D receptor	Homo sapiens	192-210
31035488-4	2019	The patients with any vitamin D formulation had higher serum concentrations of 25-hydroxy vitamin D and fibroblast growth factor-23 and tended to have higher mortality rates (42% vs. 25%, p = 0.07).	Vitamin D	22-31	fibroblast growth factor 23	Homo sapiens	104-131
30157994-0	2019	Therapeutic Efficacy of Vitamin D in Experimental c-MET-beta-Catenin-Driven Hepatocellular Cancer.	Vitamin D	24-33	catenin (cadherin associated protein), beta 1	Mus musculus	56-68
30157994-2	2019	Although Wnt/beta-catenin signaling can be targeted by vitamin D, therapeutic use of vitamin D for this purpose is not currently established.	Vitamin D	55-64	catenin (cadherin associated protein), beta 1	Mus musculus	13-25
30975133-1	2019	BACKGROUND: Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	120-138
30975133-1	2019	BACKGROUND: Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	140-143
30959822-1	2019	The vitamin D receptor (VDR) mediates vitamin D actions beyond bone health.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
30959822-8	2019	Cell proliferation assays corroborated this conjectured oppositional basal VDR activity, indicating that precise 1,25D dosage in target tissues might be essential for modulating vitamin D actions in human health.	Vitamin D	178-187	vitamin D receptor	Homo sapiens	75-78
30470461-1	2019	BACKGROUND: The aim of this study was to assess the prognostic value of vitamin D, vitamin D binding protein (VDBP) and vitamin D-related peptides in septic shock patients in relation to hospital mortality.	Vitamin D	83-92	GC vitamin D binding protein	Homo sapiens	110-114
30639520-12	2019	These data suggest a key role of vitamin D in the control of inflammatory cytokine responses during DENV infection of human macrophages via the TLR4/NF-kappaB/miR-155-5p/SOCS-1 axis.	Vitamin D	33-42	microRNA 155	Homo sapiens	159-166
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	interleukin 17A	Homo sapiens	97-102
30295316-17	2019	CONCLUSIONS: Results suggest that the "perioprotective" effects of vitamin D are related to its ability to regulate inflammatory cytokine production by HGFs following AGE-RAGE interaction.	Vitamin D	67-76	long intergenic non-protein coding RNA 914	Homo sapiens	171-175
30508646-0	2019	Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.	Vitamin D	22-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	66-69
30721418-1	2019	There is a significant association exists between vitamin D deficiencies, low respiratory tract infections, and certain types of VDR gene polymorphism.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	129-132
30721418-2	2019	Various studies are being conducted to prove any such link between the different clinical conditions due to disturbed vitamin D regulation and VDR gene polymorphisms.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	143-146
30529188-3	2019	Another important aspect to be considered in the study of vitamin D and muscle fiber metabolism is related to different expression of vitamin D receptor (VDR), which varies in muscle tissue depending on age, sex, and pathology.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	134-152
30529188-3	2019	Another important aspect to be considered in the study of vitamin D and muscle fiber metabolism is related to different expression of vitamin D receptor (VDR), which varies in muscle tissue depending on age, sex, and pathology.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	154-157
30922377-13	2019	CONCLUSIONS: Both analogs of vitamin D revealed their anti-inflammatory effect and reduced the level of Il-17A and Il-23 in the airway of CF patients with chronic P. aeruginosa infection.	Vitamin D	29-38	interleukin 17A	Homo sapiens	104-110
30971944-3	2019	FGF23 is a hormone that is mainly known as the core regulator of phosphate and vitamin D metabolism and it has been recognized as an important regulator of bone mineralization.	Vitamin D	79-88	fibroblast growth factor 23	Mus musculus	0-5
30911673-1	2019	Fibroblast growth factor receptor (FGFR) and alpha-Klotho transduce FGF-23 signaling in renal tubules to maintain systemic phosphate/vitamin D homeostasis.	Vitamin D	133-142	klotho	Mus musculus	51-57
30911673-1	2019	Fibroblast growth factor receptor (FGFR) and alpha-Klotho transduce FGF-23 signaling in renal tubules to maintain systemic phosphate/vitamin D homeostasis.	Vitamin D	133-142	fibroblast growth factor 23	Mus musculus	68-74
30963028-8	2019	Results: WES revealed gene variants involved in iron absorption and transport, in the transmembrane protease, serine 6 (TMPRSS6) and transferrin (TF) genes; multiple genetic variants in CUBN, which encodes cubilin (a receptor involved in the absorption of vitamin B12 as well as the reabsorption of transferrin-bound iron and vitamin D in the kidneys); SLC25A37 (involved in iron transport into mitochondria) and CD163 (a scavenger receptor involved in hemorrhage resolution).	Vitamin D	326-335	cubilin	Homo sapiens	206-213
30909513-2	2019	Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases.	Vitamin D	73-82	fibroblast growth factor 23	Homo sapiens	31-36
30976148-1	2019	Purpose: To assess age related manifestations of the femur and tibia in patients with vitamin D-resistant rickets (VDR) and explore causes for recurrent deformity using imaging modalities.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	115-118
30874583-4	2019	In contrast to cultivation in conventional tissue culture settings, on-chip cultivation of HepG2 and RPTEC cells in interconnected chambers, used to mimic the liver and kidneys, respectively, resulted in the enhanced expression of vitamin D metabolizing enzymes (CYP2R1, CYP27B1 and CYP24A1).	Vitamin D	231-240	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	283-290
30845908-3	2019	Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	60-78
30845908-3	2019	Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	80-83
30845908-3	2019	Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	100-103
30890957-1	2019	The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	180-198
30890957-1	2019	The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	200-203
30890957-1	2019	The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	180-198
30890957-1	2019	The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	200-203
30890957-2	2019	Since the evolutionary role of nuclear receptors, such as VDR, was the regulation of cellular metabolism, the control of calcium metabolism became the primary function of vitamin D and its receptor.	Vitamin D	171-180	vitamin D receptor	Homo sapiens	58-61
30003595-1	2019	AIM: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and beta-defensin-2, which are expressed in the urinary tract.	Vitamin D	5-14	defensin beta 4B	Homo sapiens	95-110
30173501-0	2019	Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression.	Vitamin D	0-9	heme oxygenase 1	Rattus norvegicus	81-97
29602956-0	2019	Effects of vitamin D supplementation on FGF23: a randomized-controlled trial.	Vitamin D	11-20	fibroblast growth factor 23	Homo sapiens	40-45
30984586-1	2019	Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	105-123
30984586-1	2019	Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	125-128
30984586-13	2019	Conclusion: The single nucleotide gene polymorphisms of various VDR genes as found in the cases might lead to vitamin D deficiency, due to VDR dysfunction, which in turn could increase the susceptibility to develop vitiligo.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	64-67
30774661-2	2019	The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC).	Vitamin D	92-101	GC vitamin D binding protein	Homo sapiens	114-139
30774661-2	2019	The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC).	Vitamin D	92-101	GC vitamin D binding protein	Homo sapiens	141-145
30631035-0	2019	Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D.	Vitamin D	134-143	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	104-111
30631035-5	2019	Our study indicates that the acidosis-CYP24A1-vitamin D pathway may be a key regulator of the cancer stem cell phenotype in malignant glioma and point out the potential value for the utilization of vitamin D to target cancer stem cells and to restrain the growth of malignant glioma in the future.	Vitamin D	46-55	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	38-45
30631035-5	2019	Our study indicates that the acidosis-CYP24A1-vitamin D pathway may be a key regulator of the cancer stem cell phenotype in malignant glioma and point out the potential value for the utilization of vitamin D to target cancer stem cells and to restrain the growth of malignant glioma in the future.	Vitamin D	198-207	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	38-45
30133162-7	2019	Endotoxaemia augmented plasma levels of PTH and affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression.	Vitamin D	104-113	fibroblast growth factor 23	Mus musculus	61-88
30133162-7	2019	Endotoxaemia augmented plasma levels of PTH and affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression.	Vitamin D	104-113	fibroblast growth factor 23	Mus musculus	90-95
30399574-2	2019	Vitamin D executes its functions by interacting with the vitamin D receptor (VDR), both in healthy and diseased individuals, including oral cancer.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	57-75
30399574-2	2019	Vitamin D executes its functions by interacting with the vitamin D receptor (VDR), both in healthy and diseased individuals, including oral cancer.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	77-80
30551386-5	2019	In regard to its effect on liver fibrosis, vitamin D possesses an anti-fibrotic effect on hepatic stellate cells via vitamin D receptor-mediated specific signal transduction pathways, which in turn inhibit expression of pro-fibrogenic genes.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	117-135
31257315-1	2019	To develop potent ligands for the vitamin D receptor (VDR), we designed and synthesized a series of vitamin D analogues with and without 22-alkyl substituents.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	54-57
30192652-4	2019	We selected four single nucleotide polymorphisms (SNPs; rs1993116 and rs10741657 of CYP2R1; rs4809957 and rs6068816 of CYP24A1) for genotyping in 525 control subjects and 324 hypertensive patients, and detected vitamin D levels in blood in subsets of these groups.	Vitamin D	211-220	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	119-126
31235092-3	2019	Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	120-138
31235092-3	2019	Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	140-143
31332993-0	2019	Vitamin D Increases Percentages of Interleukin-10 Secreting Regulatory T Cells in Children with Cow"s Milk Allergy.	Vitamin D	0-9	interleukin 10	Homo sapiens	35-49
31332993-4	2019	This study aimed to assess Vitamin D status in children with physician-diagnosed CMA and to investigate the effect of in vitro cultivation with Vitamin D on the percentage of antigen-driven CD4+CD25highFoxp3+IL10+ Treg cells following in vitro stimulation of cells with cow"s milk allergen in culture.	Vitamin D	144-153	interleukin 10	Homo sapiens	208-212
30044963-0	2019	Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	74-92
30044963-8	2019	The relative amounts of these VDR categories in TADs showed to be the main discriminator for sorting the latter into five classes carrying vitamin D target genes involved in distinct biological processes.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	30-33
30044963-9	2019	In conclusion, via the application of machine learning methods we identified the spatio-temporal VDR binding pattern in TADs as the most critical attribute for specific regulation of vitamin D target genes and the segregation of vitamin D"s physiologic function.	Vitamin D	183-192	vitamin D receptor	Homo sapiens	97-100
30044963-9	2019	In conclusion, via the application of machine learning methods we identified the spatio-temporal VDR binding pattern in TADs as the most critical attribute for specific regulation of vitamin D target genes and the segregation of vitamin D"s physiologic function.	Vitamin D	229-238	vitamin D receptor	Homo sapiens	97-100
31288237-1	2019	BACKGROUND/AIMS: The CYP24A1 gene encodes the vitamin D 24-hydroxylase enzyme, which hydroxylates active forms of vitamin D into inactive forms.	Vitamin D	46-55	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	21-28
31288237-2	2019	Biallelic mutations in the CYP24A1 gene can lead to elevated levels of active vitamin D metabolites and, consequently, to hypercalcemia, hypercalciuria, nephrocalcinosis, and nephrolithiasis; however, monoallelic mutations have been associated only with milder phenotypes.	Vitamin D	78-87	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	27-34
30358420-0	2019	Modulation of VDR and Cell Cycle-Related Proteins by Vitamin D in Normal Pancreatic Cells and Poorly Differentiated Metastatic Pancreatic Cancer Cells.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	14-17
30358420-6	2019	A further increase in 1,25-dihydroxyvitamin D3 concentration above the physiological range significantly downregulated the expression of VDR, indicating that VDR is modulated by VDR levels to maintain normal functioning during dramatic variations in vitamin D concentration.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	137-140
30358420-6	2019	A further increase in 1,25-dihydroxyvitamin D3 concentration above the physiological range significantly downregulated the expression of VDR, indicating that VDR is modulated by VDR levels to maintain normal functioning during dramatic variations in vitamin D concentration.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	158-161
30358420-6	2019	A further increase in 1,25-dihydroxyvitamin D3 concentration above the physiological range significantly downregulated the expression of VDR, indicating that VDR is modulated by VDR levels to maintain normal functioning during dramatic variations in vitamin D concentration.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	158-161
30562127-3	2019	We report here original findings on the ways in which vitamin D receptor (VDR) gene polymorphic variation (FokI, BsmI, ApaI, and TaqI polymorphisms) impacts serum vitamin D concentration and, additionally, susceptibility to OSAS.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	74-77
30562127-7	2019	VDR FokI polymorphism explained 14.5% of vitamin D serum concentration variability.	Vitamin D	41-50	vitamin D receptor	Homo sapiens	0-3
30218750-1	2018	Vitamin D binding protein (VDBP) plays an important role in the immune modulation and pathogenesis of hepatitis C viral (HCV) infection by influencing serum vitamin D levels.	Vitamin D	157-166	GC vitamin D binding protein	Homo sapiens	27-31
30648951-1	2018	2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	128-146
30648951-1	2018	2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	148-151
30648951-1	2018	2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity.	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	246-253
30092343-3	2018	Vitamin D activity is mediated by its receptor (VDR), which acts as a transcription factor modulating the expression of genes triggering the response against viruses.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	48-51
30395535-4	2018	The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	218-236
30395535-4	2018	The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	238-241
30395535-4	2018	The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR).	Vitamin D	144-153	vitamin D receptor	Homo sapiens	218-236
30395535-4	2018	The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR).	Vitamin D	144-153	vitamin D receptor	Homo sapiens	238-241
30373854-10	2018	Taken together, our data suggest that Klotho deficiency causes thymic involution via systemic effects that include high active vitamin D levels.	Vitamin D	127-136	klotho	Mus musculus	38-44
29972092-3	2018	Among these, vitamin D and hence its receptor (VDR) gene polymorphisms have gained much interest; however, the results are still controversial.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	47-50
30560829-11	2018	High serum GGT level, dyslipidemia, 24-hour UPE &gt;=3.5 g/24 hrs, and treatment with glucocorticoids are independent associated factors of vitamin D deficiency.	Vitamin D	140-149	inactive glutathione hydrolase 2	Homo sapiens	11-14
30555790-1	2019	Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	232-235
30555790-1	2019	Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	57-60
30555790-1	2019	Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	232-235
30484666-1	2018	Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	128-146
30484666-1	2018	Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	148-151
30484666-1	2018	Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR).	Vitamin D	54-63	vitamin D receptor	Homo sapiens	128-146
30484666-1	2018	Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR).	Vitamin D	54-63	vitamin D receptor	Homo sapiens	148-151
30481178-3	2018	Vitamin D has been shown to control several host immunomodulating properties through VDR gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	85-88
30408071-8	2018	Maternal vitamin D deficiency was found in all pathological pregnancies combined with significantly reduced staining levels of placental VDR in IUGR.	Vitamin D	9-18	vitamin D receptor	Homo sapiens	137-140
30408071-9	2018	Finally, there was a strong and significant negative correlation between the survival capacity (MAP1LC3B/BECN1) and both maternal vitamin D and placental VDR in the preeclampsia groups.	Vitamin D	130-139	beclin 1	Homo sapiens	105-110
30400332-5	2018	Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	87-105
30400332-5	2018	Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	107-110
30400332-5	2018	Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form.	Vitamin D	87-96	vitamin D receptor	Homo sapiens	107-110
30386121-10	2018	Moreover, the changes in IL-17A over the treatment period were significantly associated with vitamin D changes (beta=-0.04, SE=0.02, P=0.046).	Vitamin D	93-102	interleukin 17A	Homo sapiens	25-31
30257386-0	2018	Astemizole promotes the anti-tumor effect of vitamin D through inhibiting miR-125a-5p-meidated regulation of VDR in HCC.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	109-112
30257386-7	2018	Downregulation of VDR significantly inhibited the synergistic effect of Vitamin D and astemizole on HCC cell viability, proliferation, apoptosis, migration and invasion.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	18-21
30257386-13	2018	We identified that inhibition of miR-125a-5p and subsequent upregulation of VDR was involved in astemizole-induced enhancement of the anti-tumor effect of Vitamin D in HCC.	Vitamin D	155-164	vitamin D receptor	Homo sapiens	76-79
30268505-7	2018	Additionally, the binding affinity of the vitamin D analogs for the wild-type and the rickets-associated mutant R274L of VDR was evaluated.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	121-124
30352957-0	2018	Summary Outcomes of the ODIN Project on Food Fortification for Vitamin D Deficiency Prevention.	Vitamin D	63-72	ankyrin repeat and sterile alpha motif domain containing 1A	Homo sapiens	24-28
30352957-1	2018	Food-based solutions for optimal vitamin D nutrition and health through the life cycle (ODIN) was a cross-disciplinary, collaborative project, including 30 partners from 19 countries, which aimed to develop evidence-based solutions to prevent low vitamin D status (25-hydroxyvitamin D (25(OH)D) &lt; 30 nmol/L) using a food-first approach.	Vitamin D	33-42	ankyrin repeat and sterile alpha motif domain containing 1A	Homo sapiens	88-92
30352957-1	2018	Food-based solutions for optimal vitamin D nutrition and health through the life cycle (ODIN) was a cross-disciplinary, collaborative project, including 30 partners from 19 countries, which aimed to develop evidence-based solutions to prevent low vitamin D status (25-hydroxyvitamin D (25(OH)D) &lt; 30 nmol/L) using a food-first approach.	Vitamin D	247-256	ankyrin repeat and sterile alpha motif domain containing 1A	Homo sapiens	88-92
30352957-10	2018	Using a series of food production studies, food-based RCTs and dietary modelling experiments, ODIN research shows that diverse fortification strategies could safely increase population intakes and prevent low vitamin D status.	Vitamin D	209-218	ankyrin repeat and sterile alpha motif domain containing 1A	Homo sapiens	94-98
30326825-13	2018	CONCLUSIONS: These findings indicate that VDR expression is downregulated in HBV-transfected cells, thereby preventing vitamin D from inhibiting transcription and translation of HBV in vitro.	Vitamin D	119-128	vitamin D receptor	Homo sapiens	42-45
30300363-8	2018	In contrast, infection of IL-10-derived MPhi, similar to MPhi in lesions from patients with the progressive form of leprosy, resulted in induction of type I IFN and suppression of the vitamin D directed pathway.	Vitamin D	184-193	interleukin 10	Homo sapiens	26-31
30349256-2	2018	Through interaction with its receptor (VDR) and the related enzymes (CYP27B1, CYP24A1), vitamin D modulates neurodevelopment, neuroprotection, and immunomodulation.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	39-42
30349256-2	2018	Through interaction with its receptor (VDR) and the related enzymes (CYP27B1, CYP24A1), vitamin D modulates neurodevelopment, neuroprotection, and immunomodulation.	Vitamin D	88-97	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	78-85
30157189-8	2018	Vitamin D increased HBEC expression of the antioxidant pathway gene G6PD, increased the ratio of reduced to oxidised glutathione, and in PM-stimulated cultures decreased the formation of 8-isoprostane.	Vitamin D	0-9	glucose-6-phosphate dehydrogenase	Homo sapiens	68-72
30157189-9	2018	Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.	Vitamin D	19-28	glucose-6-phosphate dehydrogenase	Homo sapiens	147-151
30157189-9	2018	Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.	Vitamin D	234-243	glucose-6-phosphate dehydrogenase	Homo sapiens	147-151
31194013-2	2019	We construct this case-control study to investigate the association between maternal serum vitamin D level &amp; VDR gene Fok1 polymorphism and risk of congenital heart defects (CHD) in offspring.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	113-116
30197603-1	2018	Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood.	Vitamin D	40-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	101-119
30197603-1	2018	Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood.	Vitamin D	40-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	121-124
30197603-1	2018	Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood.	Vitamin D	40-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	216-219
30110122-6	2018	The discovery of vitamin D receptor (VDR) presence outside the skeletal system allowed to conclude, that vitamin D is responsible not only for mineral economy, but also for immunological processes, respiratory status, intestial microflora and cystic fibrosis - related diabetes (CFRD) course.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
30210711-7	2018	In vivo, a vitamin D-deficiency VDR-/- and WT mouse model was established and the mice were vaccinated with BCG.	Vitamin D	11-20	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	32-35
29996894-9	2018	RESULTS: Of the CpGs in vitamin D-related genes, cg21201924 (RXRA) had the lowest p value for association with 25(OH)D (p = 0.0004).	Vitamin D	24-33	retinoid X receptor alpha	Homo sapiens	61-65
30038585-7	2018	When the mice were challenged by a vitamin D deficient diet, serum FGF23 concentration and TRPV5 membrane abundance were decreased, but NCX1 abundance remained increased.	Vitamin D	35-44	fibroblast growth factor 23	Mus musculus	67-72
30038585-7	2018	When the mice were challenged by a vitamin D deficient diet, serum FGF23 concentration and TRPV5 membrane abundance were decreased, but NCX1 abundance remained increased.	Vitamin D	35-44	solute carrier family 8 (sodium/calcium exchanger), member 1	Mus musculus	136-140
30038585-8	2018	Collectively, renal distal calcium transport proteins (TRPV5 and Calbindin-D28k) in this model were altered by Memo- and vitamin-D dependent mechanisms, except for NCX1 which was vitamin D-independent.	Vitamin D	121-130	calbindin 1	Mus musculus	65-79
29476020-8	2018	In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	35-38
29588137-6	2018	Serum and gamma glutamyl transferase (GGT) level was also significantly decreased compared to the baseline levels after 12 weeks of treatment with vitamin D.	Vitamin D	147-156	gamma-glutamyltransferase 1	Homo sapiens	10-36
29588137-6	2018	Serum and gamma glutamyl transferase (GGT) level was also significantly decreased compared to the baseline levels after 12 weeks of treatment with vitamin D.	Vitamin D	147-156	gamma-glutamyltransferase 1	Homo sapiens	38-41
29588137-8	2018	CONCLUSION: While significant reduction of serum alkaline phosphatase and GGT were seen with vitamin D and calcitriol supplementation from baseline levels, no beneficial effects was seen when comparing vitamin D, calcitriol and placebo groups at the end of trial.	Vitamin D	93-102	gamma-glutamyltransferase 1	Homo sapiens	74-77
29751971-11	2018	Real-time PCR analyses of kidney CYP27B1 and CYP24A1 expression in wild type mice showed that exogenous antidiuretic hormone blocked FGF23"s actions on these vitamin D activating or inactivating enzymes.	Vitamin D	158-167	fibroblast growth factor 23	Mus musculus	133-138
29875736-3	2018	Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy.	Vitamin D	78-87	GC vitamin D binding protein	Homo sapiens	0-25
29875736-3	2018	Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy.	Vitamin D	78-87	GC vitamin D binding protein	Homo sapiens	27-31
29795187-1	2018	Epidemiological studies have confirmed associations of the vitamin D receptor (VDR) and vitamin D-related gene polymorphisms with adiposity and other metabolic disturbances.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	79-82
30283909-2	2018	Activation of vitamin D by renal 1alpha-hydroxylation is dependent on protein binding because 1,25-dihydroxyvitamin D (1,25(OH)2D3) is formed after megalin-mediated reabsorption of 25-hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP).	Vitamin D	14-23	GC vitamin D binding protein	Homo sapiens	218-243
29771914-0	2018	Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3.	Vitamin D	14-23	fibroblast growth factor 23	Mus musculus	106-111
29771914-2	2018	Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation.	Vitamin D	0-9	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	185-192
29769621-7	2018	Progressive trends (P &lt; 0.05) towards increased CD8 and CD4/CD8 were observed in vitamin-D-deficient T2DM and hypertension patients.	Vitamin D	84-93	CD8a molecule	Homo sapiens	51-54
29769621-7	2018	Progressive trends (P &lt; 0.05) towards increased CD8 and CD4/CD8 were observed in vitamin-D-deficient T2DM and hypertension patients.	Vitamin D	84-93	CD8a molecule	Homo sapiens	63-66
29769621-8	2018	Significant differences (P &lt; 0.05) in CD8 were observed in vitamin-D-deficient CAD patients, whereas significant differences (P &lt; 0.05) in CD8 and CD19 were observed in CRVD patients.	Vitamin D	62-71	CD8a molecule	Homo sapiens	41-44
29769621-10	2018	Increases in CD8-positive lymphocytes suggested a similar, less pronounced effect in vitamin-D-deficient CRVD and CAD patients.	Vitamin D	85-94	CD8a molecule	Homo sapiens	13-16
29652161-1	2018	A convergent synthesis of side-chain locked vitamin D analogs 3 and 4, which bind strongly in silico to the vitamin D receptor (VDR), is described.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	108-126
29652161-1	2018	A convergent synthesis of side-chain locked vitamin D analogs 3 and 4, which bind strongly in silico to the vitamin D receptor (VDR), is described.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	128-131
29486367-13	2018	CONCLUSIONS: After a 14-day lag, a single high dose of vitamin D led to greater production of 24,25(OH)2D3, presumably via induction of the 24-hydroxylase enzyme (CYP24A1), relative to the 25(OH)D3 value than did daily vitamin D supplementation, and this effect persisted for at least 28days after vitamin D administration.	Vitamin D	219-228	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	163-170
29486367-13	2018	CONCLUSIONS: After a 14-day lag, a single high dose of vitamin D led to greater production of 24,25(OH)2D3, presumably via induction of the 24-hydroxylase enzyme (CYP24A1), relative to the 25(OH)D3 value than did daily vitamin D supplementation, and this effect persisted for at least 28days after vitamin D administration.	Vitamin D	219-228	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	163-170
29786188-1	2018	Mutations of the CYP24A1 gene are associated with alterations in the activity of the enzyme 25-OH-D-24-hydroxylase, resulting in dysfunction of the metabolism of vitamin D.	Vitamin D	162-171	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	17-24
29461981-1	2018	Genetic forms of vitamin D-dependent rickets (VDDRs) are due to mutations impairing activation of vitamin D or decreasing vitamin D receptor responsiveness.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	122-140
29461981-4	2018	In vitro, the mutant CYP3A4 oxidized 1,25-dihydroxyvitamin D with 10-fold greater activity than WT CYP3A4 and 2-fold greater activity than CYP24A1, the principal inactivator of vitamin D metabolites.	Vitamin D	51-60	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	139-146
29528271-3	2018	Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.	Vitamin D	99-108	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	147-154
29080365-2	2018	Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	182-200
29080365-2	2018	Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	202-205
29281615-9	2018	The vitamin D/VDR pathway protects against intestinal injury of NEC partly through suppressing the expression of TLR4.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	14-17
29669566-3	2018	Vitamin D acts in tissues through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	38-56
29669566-3	2018	Vitamin D acts in tissues through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	58-61
29719821-7	2018	SLC37A1 seems to be required for lipid biosynthesis in cancer cell lines, SLC37A2 has been proposed as a vitamin D and a phospho-progesterone receptor target gene, while mutations in the SLC37A3 gene appear to be associated with congenital hyperinsulinism of infancy.	Vitamin D	105-114	solute carrier family 37 member 2	Homo sapiens	74-81
29782293-0	2018	Mycosis Fungoides and Vitamin D Status: Analyses of Serum 25-Hydroxyvitamin D Levels and Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	128-146
29343609-0	2018	Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans.	Vitamin D	119-128	sulfotransferase family 2A member 1	Homo sapiens	18-38
29343609-6	2018	Further analysis revealed a significant association between a common single nucleotide variant within intron 1 of SULT2A1 (rs296361; minor allele frequency = 15% in whites) and liver cytosolic SULT2A1 content as well as 25OHD3-3-O-sulfate formation rate, suggesting that variation in the SULT2A1 gene contributes importantly to interindividual differences in vitamin D homeostasis.	Vitamin D	359-368	sulfotransferase family 2A member 1	Homo sapiens	114-121
29679282-3	2018	Inhibition of FGF23 by burosumab results in increased renal phosphate reabsorption and increased serum levels of phosphorus and active vitamin D.	Vitamin D	135-144	fibroblast growth factor 23	Homo sapiens	14-19
29196501-0	2018	Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women.	Vitamin D	49-58	GC vitamin D binding protein	Homo sapiens	0-25
29196501-9	2018	Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women.	Vitamin D	49-58	GC vitamin D binding protein	Homo sapiens	0-25
29425808-4	2018	The resistance to CYP24A1-dependent metabolism could be an important property of vitamin D analogs in prolonging their biological effects.	Vitamin D	81-90	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	18-25
28087977-9	2018	The reduced levels of Vitamin D, and urinary losses may contribute to lower levels of FGF23 in NS.	Vitamin D	22-31	fibroblast growth factor 23	Homo sapiens	86-91
28765041-2	2018	The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known.	Vitamin D	12-21	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-61
29146302-1	2018	Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and osteocytes.	Vitamin D	16-25	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	86-104
29146302-1	2018	Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and osteocytes.	Vitamin D	16-25	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	106-109
29146302-8	2018	However, using our cKO lines, we observed that VDR in osteoblast-lineage cells, but not osteoclasts, was involved in the anti-resorptive properties of pharmacological doses of vitamin D compounds in vivo.	Vitamin D	176-185	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	47-50
29561429-3	2018	Deficiency of vitamin D and decreased levels of its receptor were observed in HCV and HCV-HCC patients.The perturbation in vitamin D/VDR axis, which modulates both of autophagy and apoptosis in HCV infection, may point out to its involvement and implication in the pathogenesis of HCV infection and the development of HCV-related HCC.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	133-136
29467039-2	2018	The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	168-171
27925404-8	2018	Vitamin D inhibits the production of several proinflammatory cytokines and leads to suppression Th1 and Th17 responses which may be involved in the pathogenesis of COPD.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	96-99
29018141-6	2018	Overexpression of VDR in SH-SY5Y in the absence of ligand (mimicking in vivo developmental vitamin D deficiency) also suppressed C-Ret mRNA levels.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	18-21
29510848-3	2018	The groups were formed according to BTMD data, ethnic affiliation and according to content of vitamin D and gene polymorphism of vitamin D (VDR).	Vitamin D	129-138	vitamin D receptor	Homo sapiens	140-143
29205876-2	2018	Here, we sought to study the impact of the vitamin D receptor (Vdr) on adipocyte size in young and old mice and the effect of maternal vitamin D deficiency on fetal adipogenesis.	Vitamin D	43-52	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	63-66
29162485-13	2018	In astrocytes 3beta-HSD was also suppressed by vitamin D, about 20% at the enzyme activity level and 60% at the mRNA level.	Vitamin D	47-56	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	14-23
29357898-1	2018	BACKGROUND: To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60.	Vitamin D	81-90	GC vitamin D binding protein	Homo sapiens	107-132
29357898-1	2018	BACKGROUND: To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60.	Vitamin D	92-101	GC vitamin D binding protein	Homo sapiens	107-132
29351340-7	2018	HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice.	Vitamin D	8-17	tripartite motif-containing 63	Mus musculus	82-87
29375203-12	2018	Treatment of re-cultured PSCs with Dvitamins was associated with lower expression of IL-6 (-42% to -49%; P &lt; 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene (209%-321% vs controls; P &lt; 0.05).	Vitamin D	35-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	187-205
29258108-0	2018	Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	77-95
29258108-3	2018	The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) gene expression.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	113-131
29258108-3	2018	The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) gene expression.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	133-136
29258108-10	2018	Linear regression analysis used to show the mediatory role of VDR and PGC-1alpha on the RMR/kg body weight and vitamin D status relationship.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	62-65
29258108-11	2018	Our results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status (beta = 0.38, 95% CI -0.48 to 1.60; beta = -1.24, 95% CI -5.36 to 1.70).	Vitamin D	102-111	vitamin D receptor	Homo sapiens	24-27
30588177-6	2018	Immune modulation by vitamin D includes enhancing innate immune response, attenuating and stimulating Th1 and Th2 cell proliferation, respectively, and promoting self-tolerance.	Vitamin D	21-30	negative elongation factor complex member C/D	Homo sapiens	102-105
29874993-2	2018	Currently, several Vitamin D analogues have been synthesized and tested against VDR (Vitamin D Receptor).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	80-83
29874993-10	2018	Furthermore, the hydroxyl group in the side chain of vitamin D analogues played an important role in the VDR antagonistic activity.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	105-108
30041203-1	2018	Fibroblast growth factor 23 (FGF23) is a regulator of phosphate and vitamin D homeostasis that carries out primary bone- and mineral-related physiological functions to increase renal phosphate excretion and reduce 1alpha-hydroxylation of 25-hydroxyvitamin D.	Vitamin D	68-77	fibroblast growth factor 23	Homo sapiens	0-27
30041203-1	2018	Fibroblast growth factor 23 (FGF23) is a regulator of phosphate and vitamin D homeostasis that carries out primary bone- and mineral-related physiological functions to increase renal phosphate excretion and reduce 1alpha-hydroxylation of 25-hydroxyvitamin D.	Vitamin D	68-77	fibroblast growth factor 23	Homo sapiens	29-34
30039758-2	2018	The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	60-78
30039758-2	2018	The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	80-83
30039758-4	2018	METHODS: We presented a comprehensive review of the evidence on the role of genetic polymorphisms, especially those of VDR, in vitamin D-related disorders including their clinical implications.	Vitamin D	127-136	vitamin D receptor	Homo sapiens	119-122
29780234-2	2018	The aim of this study is to evaluate the body mass index (BMI) and vitamin D levels in CTS patients.	Vitamin D	67-76	transthyretin	Homo sapiens	87-90
29780234-9	2018	Those with severe CTS had a significantly higher BMI and lower vitamin D levels than the others (p = 0.03 and p = 0.01 respectively).	Vitamin D	63-72	transthyretin	Homo sapiens	18-21
29143122-11	2018	Monitoring oxidative stress and VDR protein content might be useful for future studies on the mechanism(s) of vitamin D action in muscle.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	32-35
29131543-9	2018	In addition, HLA-DRB1*15:01 and HLA-DQB1*06:02 were found to be associated with lower vitamin D levels.	Vitamin D	86-95	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	32-40
29183090-9	2018	In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	163-166
29945780-11	2018	However, subjects with "insufficient" Vitamin D < 30 ng/mL (n = 10) had an ~2-fold greater CK increase with eccentric exercise (nominal P-value = .04) than subjects with higher vitamin D levels.	Vitamin D	38-47	cytidine/uridine monophosphate kinase 1	Homo sapiens	91-93
29945780-13	2018	We did observe that low vitamin D levels are associated with a greater CK response to eccentric exercise in statin-treated subjects.	Vitamin D	24-33	cytidine/uridine monophosphate kinase 1	Homo sapiens	71-73
29710028-4	2018	The protein expressions of markers linked with the vitamin D action were altered by VDD (vitamin D receptor VDR, 25-hydroxyvitamin D-24-hydroxylase CYP24A1, CYP27B1, and CYP2R1).	Vitamin D	51-60	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	148-155
29067566-7	2018	At its optimal values (&gt;30 ng/ml), vitamin D requires vitamin A for the binding to the vitamin D receptor and exert its anti-inflammatory action.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	90-108
29254801-2	2018	CYP24A1, the main enzyme responsible for the degradation of active vitamin D, plays an important role in many cancer related cellular processes.	Vitamin D	67-76	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
30300431-1	2018	Vitamin D activity is controlled by its receptor (VDR) located in many cells of the body.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	50-53
30380963-11	2018	A positive correlation was found between FGF23 and phosphate, parathyroid hormone (PTH) and vitamin D, 25(OH)D and 1,25(OH)2D-total assays, respectively.	Vitamin D	92-101	fibroblast growth factor 23	Homo sapiens	41-46
28876961-16	2018	CONCLUSIONS: As a consequence of the presence of VDR and 1alpha-hydroxylase in different parts of the eye, vitamin D replacement improves tear hyperosmolarity that is considered to be induced by ocular surface inflammation.	Vitamin D	107-116	vitamin D receptor	Homo sapiens	49-52
29281967-10	2017	Vitamin D administrations reduced IL-1beta, NF-Kbeta and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group.	Vitamin D	0-9	brain-derived neurotrophic factor	Rattus norvegicus	89-93
29299028-9	2017	Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant.	Vitamin D	68-77	interleukin 10	Homo sapiens	131-136
29299028-9	2017	Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant.	Vitamin D	68-77	interleukin 17A	Homo sapiens	156-161
29269725-6	2017	Through immunofluorescence staining and luciferase reporter assay, we found that Vitamin D Response Element (VDRE) affected IFN-activated site (Gamma-activated sequence, GAS) function at the transcriptional level and was involved in the inhibition of K17 expression.	Vitamin D	81-90	keratin 17	Homo sapiens	251-254
29272316-4	2017	Many of vitamin D"s actions are mediated through vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	49-67
29272316-4	2017	Many of vitamin D"s actions are mediated through vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	69-72
29457022-1	2017	CYP24A1 is an enzyme that inactivates vitamin D.	Vitamin D	38-47	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
29061851-0	2017	Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice.	Vitamin D	9-18	programmed cell death 1 ligand 2	Homo sapiens	58-63
29301185-1	2017	PURPOSE: Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation.	Vitamin D	9-18	GC vitamin D binding protein	Homo sapiens	147-172
29301185-1	2017	PURPOSE: Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation.	Vitamin D	9-18	GC vitamin D binding protein	Homo sapiens	174-178
28830874-5	2017	We considered 82 SNPs in 7 vitamin D-related genes (CYP24A1, CYP27B1, CYP2R1, GC, DHCR7/NADSYN1, RXRA, and VDR).	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	52-59
28830874-8	2017	In gene-based tests, only VDR showed strong evidence of interaction (P = 0.04).Conclusions: SNPs in vitamin D-related genes may modify the association between serum 25(OH)D and breast cancer.Impact: This work strengthens the evidence for protective effects of vitamin D. Cancer Epidemiol Biomarkers Prev; 26(12); 1761-71.	Vitamin D	100-109	vitamin D receptor	Homo sapiens	26-29
28922293-4	2017	Data obtained in experimental models of cancer cachexia show that the administration of vitamin D to tumor-bearing animals is not able to prevent or delay both muscle wasting and adipose tissue depletion, despite increased expression of muscle vitamin D receptor.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	244-262
28905271-1	2017	BACKGROUND: 2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1alpha-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	156-174
28905271-1	2017	BACKGROUND: 2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1alpha-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	156-174
29204370-0	2017	Association of vitamin D with cathelicidin and vitamin D binding protein in pediatric sepsis.	Vitamin D	15-24	GC vitamin D binding protein	Homo sapiens	47-72
28778755-7	2017	The activities of vitamin D are dependent on the vitamin D receptor (VDR), a member of the steroid nuclear receptor superfamily.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	49-67
28778755-7	2017	The activities of vitamin D are dependent on the vitamin D receptor (VDR), a member of the steroid nuclear receptor superfamily.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	69-72
28388281-1	2017	AIM: Vitamin D acts through the binding to the vitamin D receptor (VDR).	Vitamin D	5-14	vitamin D receptor	Homo sapiens	47-65
28388281-1	2017	AIM: Vitamin D acts through the binding to the vitamin D receptor (VDR).	Vitamin D	5-14	vitamin D receptor	Homo sapiens	67-70
28669880-7	2017	Biological actions of Vitamin D are mediated via its nuclear hormone receptor vitamin D receptor (VDR) and is found to regulate many genes.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	78-96
28669880-7	2017	Biological actions of Vitamin D are mediated via its nuclear hormone receptor vitamin D receptor (VDR) and is found to regulate many genes.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	98-101
28703134-1	2017	Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	164-182
28945992-9	2017	In conclusion, reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes.	Vitamin D	140-149	leukocyte immunoglobulin like receptor B1	Homo sapiens	40-45
28945992-9	2017	In conclusion, reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes.	Vitamin D	140-149	microRNA 152	Homo sapiens	87-94
28665452-1	2017	BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	66-69
28665452-1	2017	BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels.	Vitamin D	30-39	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
28665452-1	2017	BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	66-69
28665452-1	2017	BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels.	Vitamin D	139-148	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-124
28665452-2	2017	The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients.	Vitamin D	134-143	vitamin D receptor	Homo sapiens	82-85
28665452-2	2017	The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients.	Vitamin D	134-143	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	115-122
29313597-3	2017	Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	104-107
29313597-3	2017	Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	104-107
29313597-3	2017	Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	104-107
28886997-0	2017	Analysis of the binding sites of vitamin D 1alpha-hydroxylase (CYP27B1) and vitamin D 24-hydroxylase (CYP24A1) for the design of selective CYP24A1 inhibitors: Homology modelling, molecular dynamics simulations and identification of key binding requirements.	Vitamin D	33-42	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	102-109
28886997-0	2017	Analysis of the binding sites of vitamin D 1alpha-hydroxylase (CYP27B1) and vitamin D 24-hydroxylase (CYP24A1) for the design of selective CYP24A1 inhibitors: Homology modelling, molecular dynamics simulations and identification of key binding requirements.	Vitamin D	33-42	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	139-146
28976989-1	2017	BACKGROUND: Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator paricalcitol show that plasma ADMA is substantially less than in those not receiving this drug.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	215-233
28666969-9	2017	Thus, a diet-independent decrease in osteocyte number in Vdr-deficient mice suggests a mechanism that is directly dependent on the VDR, since vitamin D may promote the transition from osteoblasts to osteocytes.	Vitamin D	142-151	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	131-134
28728941-3	2017	We hypothesized that mineral homeostasis is differentially affected by R568 and 1,25D with respect to the PTH-vitamin D-FGF23-Klotho axis and bone health.	Vitamin D	110-119	fibroblast growth factor 23	Mus musculus	120-125
28728941-3	2017	We hypothesized that mineral homeostasis is differentially affected by R568 and 1,25D with respect to the PTH-vitamin D-FGF23-Klotho axis and bone health.	Vitamin D	110-119	klotho	Mus musculus	126-132
28677090-5	2017	In the simple linear regression model, Klotho levels were correlated with age, phosphorus, PTH, ACR, HOMA, IL-6, FGF-23, OxLDL, eGFR and vitamin D levels.	Vitamin D	137-146	klotho	Homo sapiens	39-45
28677090-6	2017	Applying a multivariate linear regression model, only the ACR, HOMA-IR, FGF-23 and vitamin D independently influenced the Klotho levels.	Vitamin D	83-92	klotho	Homo sapiens	122-128
28677090-10	2017	CONCLUSIONS: Our results showed that Klotho levels are influenced by FGF23, vitamin D and insulin resistance.	Vitamin D	76-85	klotho	Homo sapiens	37-43
28600880-1	2017	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating vitamin D hormone production and renal handling of minerals by signaling through an FGF receptor/alphaKlotho (Klotho) receptor complex.	Vitamin D	73-82	fibroblast growth factor 23	Mus musculus	0-27
28600880-1	2017	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating vitamin D hormone production and renal handling of minerals by signaling through an FGF receptor/alphaKlotho (Klotho) receptor complex.	Vitamin D	73-82	fibroblast growth factor 23	Mus musculus	29-34
28093352-1	2017	CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH)2D, the physiologically active vitamin D metabolite.	Vitamin D	22-31	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
28093352-6	2017	Disruption of CYP24A1 in mice results in elevated circulating 1,25-(OH)2D, substantiating the importance of the enzyme in the maintenance of vitamin D metabolism.	Vitamin D	141-150	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	14-21
28104492-4	2017	Transient transfection of Caco-2 cells with a constitutively active mutant K-RAS (G12 V) significantly reduced 1,25(OH)2D-induced activity of both a human 25-hydroxyvitamin D, 24 hydroxyase (CYP24A1) promoter-luciferase and an artificial 3X vitamin D response element (VDRE) promoter-luciferase reporter gene.	Vitamin D	165-174	KRAS proto-oncogene, GTPase	Homo sapiens	75-80
29034815-3	2017	Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	156-174
28843271-11	2017	Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	128-131
28843271-12	2017	The results suggest that vitamin D positively regulates cell-to-cell junction by increasing the VDR/p-RhoA/p-Ezrin pathway.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	96-99
28257826-2	2017	Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR).	Vitamin D	174-183	GC vitamin D binding protein	Homo sapiens	211-236
28257826-2	2017	Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR).	Vitamin D	174-183	vitamin D receptor	Homo sapiens	301-304
28257826-6	2017	Additionally, we will describe, the implications of the VDR mutants associated with hereditary vitamin D-resistant rickets (HVDRR) that display impaired function.	Vitamin D	95-104	vitamin D receptor	Homo sapiens	56-59
28315703-1	2017	The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the transcription factor VDR is the unique target of 1,25(OH)2D3 in the nucleus.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	202-205
28315703-1	2017	The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the transcription factor VDR is the unique target of 1,25(OH)2D3 in the nucleus.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	240-243
28315703-3	2017	Vitamin D has via VDR a direct effect on the expression of several hundred primary target genes implying numerous effects on the epigenome.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	18-21
28342856-2	2017	The effects of vitamin D are mediated by the vitamin D receptor, which is expressed together with the vitamin D metabolizing enzymes in the reproductive tissues.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	45-63
28526240-4	2017	Recent findings convincingly support the concept of a new function of the VDR as a tumor suppressor in skin, with key components of the vitamin D endocrine system, including VDR, CYP24A1, CYP27A1, and CYP27B1 being strongly expressed in non-melanoma skin cancer (NMSC).	Vitamin D	136-145	vitamin D receptor	Homo sapiens	74-77
28739397-1	2017	BACKGROUND: Data concerning the association of serum levels of vitamin D and metalloproteinases and vitamin D receptor gene polymorphism with coronary artery disease (CAD) is not fully demonstrated.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	100-118
28891930-4	2017	The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	95-98
28944088-2	2017	The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR).	Vitamin D	83-92	vitamin D receptor	Homo sapiens	168-186
28944088-2	2017	The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR).	Vitamin D	83-92	vitamin D receptor	Homo sapiens	188-191
28944088-5	2017	These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	34-37
28463086-0	2017	Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-gamma+ Response Driven by Urban Particulate Matter.	Vitamin D	0-9	interleukin 17A	Homo sapiens	41-57
28578001-9	2017	These findings indicate that p38alpha and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 expression.	Vitamin D	82-91	transient receptor potential cation channel subfamily V member 6	Homo sapiens	105-110
28732681-1	2017	Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described.	Vitamin D	195-204	GC vitamin D binding protein	Homo sapiens	0-25
28817905-0	2017	Re: CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations.	Vitamin D	61-70	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	101-108
28779988-2	2017	Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D.	Vitamin D	82-91	GC vitamin D binding protein	Homo sapiens	24-49
28779988-2	2017	Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D.	Vitamin D	82-91	GC vitamin D binding protein	Homo sapiens	51-55
28779988-2	2017	Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D.	Vitamin D	207-216	GC vitamin D binding protein	Homo sapiens	24-49
28779988-2	2017	Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D.	Vitamin D	207-216	GC vitamin D binding protein	Homo sapiens	51-55
28231625-1	2017	OBJECTIVE: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	84-87
28686349-1	2017	BACKGROUND: Previous studies have demonstrated that vitamin D affects T-cell function and maturation via the vitamin D receptor.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	109-127
28835228-2	2017	In the present study we assess whether vitamin D supplementation, in the follow-up period after diagnosis and surgical resection of the primary tumor, has a protective effect on relapse of cutaneous malignant melanoma and whether this protective effect correlates with vitamin D levels in serum and Vitamin D Receptor immunoreactivity in the primary tumor.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	299-317
28830368-1	2017	BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	203-206
28830368-1	2017	BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	208-226
28606476-7	2017	Our study showed that treated with appropriate concentration of active vitamin D could decrease the number of pathological pyramidal neurons, improve hippocampal nerve metabolism, and reduce the over-expression of nNOS, along with the relieved activation of ER stress in hippocampus of diabetic rats.	Vitamin D	71-80	nitric oxide synthase 1	Rattus norvegicus	214-218
28601283-3	2017	The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	156-159
28811597-2	2017	Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	109-112
28811597-10	2017	In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	99-102
28860784-13	2017	This suggests that serum FGF23 levels should be monitored regularly, especially in those who use combination of vitamin D and calcium carbonate from the early stages of CKD.	Vitamin D	112-121	fibroblast growth factor 23	Homo sapiens	25-30
28811844-0	2017	LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.	Vitamin D	61-70	lysine demethylase 1A	Homo sapiens	0-4
28811844-2	2017	Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa).	Vitamin D	41-50	lysine demethylase 1A	Homo sapiens	26-30
28811844-2	2017	Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa).	Vitamin D	41-50	vitamin D receptor	Homo sapiens	61-64
28739681-1	2017	BACKGROUND: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	46-64
28739681-1	2017	BACKGROUND: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	66-69
28739681-2	2017	The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer.	Vitamin D	72-81	vitamin D receptor	Homo sapiens	35-38
28801380-4	2017	Briefly, vitamin D immunomodulation includes attenuation and stimulation of Th1 and Th2 cell proliferation, respectively.	Vitamin D	9-18	negative elongation factor complex member C/D	Homo sapiens	76-79
28801380-5	2017	Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively.	Vitamin D	11-20	interleukin 10	Homo sapiens	113-118
28601511-1	2017	CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D).	Vitamin D	19-28	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
28601511-1	2017	CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D).	Vitamin D	19-28	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	182-189
28955691-2	2017	Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	118-137
28955691-2	2017	Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	139-142
28955691-3	2017	Vitamin D acts on target tissues via the binding of its active form to VDR.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	71-74
28445792-13	2017	In conclusion, vitamin D deficiency in old rats increases adiposity and leads to reduced muscle protein synthesis through activation of eIF2alpha.	Vitamin D	15-24	eukaryotic translation initiation factor 2A	Rattus norvegicus	136-145
27927883-1	2017	Objectives The aim of this study was to assess the vitamin D status in treatment-naive SLE patients and its association with clinical and laboratory markers of disease activity, including serum levels of IL-17 and IL-23.	Vitamin D	51-60	interleukin 17A	Homo sapiens	204-209
28433569-2	2017	Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects.	Vitamin D	60-69	GC vitamin D binding protein	Homo sapiens	0-25
28433569-2	2017	Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects.	Vitamin D	60-69	GC vitamin D binding protein	Homo sapiens	27-31
28433569-2	2017	Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects.	Vitamin D	191-200	GC vitamin D binding protein	Homo sapiens	0-25
28433569-2	2017	Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects.	Vitamin D	191-200	GC vitamin D binding protein	Homo sapiens	27-31
27622885-1	2017	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney.	Vitamin D	193-202	fibroblast growth factor 23	Homo sapiens	0-27
27622885-1	2017	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney.	Vitamin D	193-202	fibroblast growth factor 23	Homo sapiens	29-34
28989587-9	2017	Also Vitamin D deficient patients had higher serum ALP levels.	Vitamin D	5-14	ATHS	Homo sapiens	51-54
28304097-5	2017	We employed an extended 20-min run time on LC-MS/MS to study serum vitamin D metabolites in patients with IIH due to mutations of CYP24A1 or SLC34A1; in unaffected heterozygotes and dialysis patients; in patients with vitamin D deficiency; as well as in normal subjects exhibiting a broad range of 25-OH-D levels.	Vitamin D	67-76	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	130-137
28367941-1	2017	Vitamin D-dependent rickets type 2A (VDDR2A) is a rare inherited disorder with decreased tissue responsiveness to 1,25-dihydroxyvitamin D [1,25(OH)2D], caused by loss of function mutations in the vitamin D receptor (VDR) gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	196-214
28367941-1	2017	Vitamin D-dependent rickets type 2A (VDDR2A) is a rare inherited disorder with decreased tissue responsiveness to 1,25-dihydroxyvitamin D [1,25(OH)2D], caused by loss of function mutations in the vitamin D receptor (VDR) gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	216-219
28177670-4	2017	The present study was designed to investigate the effect of pretreatment with vitamin D on the isoprenaline-induced infarct-like lesion in rats and the role of PPAR-gamma as a novel mechanism in vitamin-D-mediated cardioprotective effect.	Vitamin D	195-204	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	160-170
28177670-11	2017	The prior treatment with bisphenol A diglycidyl ether (BADGE), a PPAR-gamma antagonist, significantly attenuated the protective effect of vitamin D.	Vitamin D	138-147	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	65-75
28177161-6	2017	Therefore, it is unclear what types of cells expressing VDR preferentially regulate the vitamin D-induced increase in bone mass.	Vitamin D	88-97	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	56-59
28177161-13	2017	These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.	Vitamin D	32-41	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	133-136
28116494-0	2017	Use of surface plasmon resonance in the binding study of vitamin D, metabolites and analogues with vitamin D binding protein.	Vitamin D	57-66	GC vitamin D binding protein	Homo sapiens	99-124
28008175-0	2017	CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D.	Vitamin D	78-87	microRNA 155	Homo sapiens	45-52
28336108-0	2017	Vitamin D increases PPARgamma expression and promotes beneficial effects of physical activity in metabolic syndrome.	Vitamin D	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	20-29
28336108-2	2017	The aim of the present study was to examine the effects of vitamin D supplementation and aerobic training on metabolic syndrome and PPARgamma expression.	Vitamin D	59-68	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	132-141
28336108-5	2017	RESULTS: The combination of exercise and high doses of vitamin D significantly reduced insulin (P = 0.039), blood glucose (P = 0.024), and homeostatic model assessment for insulin resistance (P = 0.011), and elevated PPARgamma gene expression (P = 0.032).	Vitamin D	55-64	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	217-226
28336108-7	2017	CONCLUSION: Findings from the present study suggested that a sedentary lifestyle and vitamin D deficiency accelerated the occurrence of metabolic syndrome probably by decreasing the expression of nuclear receptor PPARgamma.	Vitamin D	85-94	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	213-222
28423519-5	2017	Vitamin D treatment resulted in VDR overexpression and myogenin down-regulation.	Vitamin D	0-9	myogenin	Rattus norvegicus	55-63
28222207-3	2017	In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage.	Vitamin D	102-111	GC vitamin D binding protein	Homo sapiens	129-133
27714313-5	2017	There are several shared effects of vitamin D and UVR on T cells including inhibition of proliferation and suppression of IFN-gamma and IL-17 producing T cells.	Vitamin D	36-45	interleukin 17A	Homo sapiens	136-141
28163705-3	2016	In the context of autoimmune diseases, this is illustrated by correlations of vitamin D status and genetic polymorphisms in the vitamin D receptor with the incidence and severity of the disease.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	128-146
27955890-10	2017	Serum IP-10 and vitamin D levels were found to be significantly related to viral-asthma attacks (IP-10; aOR: 8.93, p=0.03 and vitamin D; aOR: 0.82, p=0.001).	Vitamin D	16-25	C-X-C motif chemokine ligand 10	Homo sapiens	97-102
27955890-10	2017	Serum IP-10 and vitamin D levels were found to be significantly related to viral-asthma attacks (IP-10; aOR: 8.93, p=0.03 and vitamin D; aOR: 0.82, p=0.001).	Vitamin D	126-135	C-X-C motif chemokine ligand 10	Homo sapiens	6-11
29179169-5	2017	In this review, I will discuss about the roles of Enpp1 in regulating the FGF23-Klotho-vitamin D axis and bones.	Vitamin D	87-96	fibroblast growth factor 23	Homo sapiens	74-79
29179169-5	2017	In this review, I will discuss about the roles of Enpp1 in regulating the FGF23-Klotho-vitamin D axis and bones.	Vitamin D	87-96	klotho	Homo sapiens	80-86
28031008-4	2017	RESULTS: Genetic vitamin D receptor (VDR) polymorphisms and other VDR biology regulation are involved in predisposition to gastrointestinal cancers and might allow tailored strategies for managing those individuals especially at risk, e.g. through vitamin D supplementation.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
27927849-4	2017	This is mainly due to the fact that gonadal function may be altered by vitamin D deficiency, as observed by the expression of vitamin D receptor mRNA in human ovaries, mixed ovarian cell cultures and granulosa cell cultures.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	126-144
28013309-1	2017	BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by the early onset of rickets and is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	172-190
28013309-1	2017	BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by the early onset of rickets and is caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	53-56
29333433-1	2017	Background: The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	36-39
29333433-2	2017	Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D) predisposition.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	16-19
28331861-4	2017	The goal of this study is to find the effect of Vitamin D administration on ICAM-1 and VCAM-1 serum levels in ESRD patients on hemodialysis.	Vitamin D	48-57	intercellular adhesion molecule 1	Homo sapiens	76-82
27520299-6	2017	Here we provide evidence that phosphorylation plays a role in controlling DHCR7 activity, which may provide a means to divert flux from cholesterol synthesis to vitamin D production.	Vitamin D	161-170	7-dehydrocholesterol reductase	Homo sapiens	74-79
27520299-9	2017	Thus, we demonstrate that phosphorylation modulates DHCR7 activity in cells, and contributes to the overall synthesis of cholesterol, and probably vitamin D.	Vitamin D	147-156	7-dehydrocholesterol reductase	Homo sapiens	52-57
27520301-6	2017	Several functions of unliganded nVDR were discovered by studying human samples from patients having hereditary vitamin D resistant rickets, transgenic mice overexpressing the VDR and VDR knockout mice.	Vitamin D	111-120	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	33-36
27922682-1	2017	Active vitamin D has several antitumor effects, including prodifferentiative, antiproliferative and proapoptotic functions in a number of tissues via its binding to vitamin D receptor.	Vitamin D	7-16	vitamin D receptor	Homo sapiens	165-183
27922682-2	2017	The 24-hydroxylase (CYP24A1) and 1-hydroxylase (CYP27B1) enzymes are considered to be pivotal determinants of the local concentration of active vitamin D.	Vitamin D	144-153	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	20-27
27922682-9	2017	Local alterations in the anabolism and catabolism of active vitamin D in breast cancer by the CYP27B1 and CYP24A1 may impair its anticancer functions.	Vitamin D	60-69	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	106-113
27037181-3	2017	OBJECTIVES: To show that vitamin D sufficient patients (25-hydroxy vitamin D (25(OH)D) &gt; 80 nmol/L) have better optical coherence tomography (OCT) neuroaxonal measures of ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thickness after optic neuritis.	Vitamin D	25-34	germ cell-less 2, spermatogenesis associated	Homo sapiens	195-198
30695614-0	2017	[The study of the association between rs2228570 polymorphism of VDR gene and vitamin D blood serum concentration in the inhabitants of the Russian Arctic].	Vitamin D	77-86	vitamin D receptor	Homo sapiens	64-67
30695614-2	2017	The aim of this study was to evaluate the possible association between VDR FokI polymorphism and vitamin D sufficiency in the population of the Yamal-Nenets Autonomous District of the Russian Federation.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	71-74
30695614-12	2017	Thus, the association between C allele presence of rs2228570 polymorphism of VDR gene and a deficiency of vitamin D (reduced levels of 25 (OH)D in blood serum) has been revealed.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	77-80
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	63-66
27652999-2	2016	RECENT FINDINGS: FGF-23 is a hormone produced by osteocytes and osteoblasts that aids with phosphate excretion by the kidney and acts as a negative feedback regulator for activated vitamin D synthesis.	Vitamin D	181-190	fibroblast growth factor 23	Homo sapiens	17-23
27420410-0	2016	Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population.	Vitamin D	54-63	vitamin D receptor	Homo sapiens	68-86
27721113-10	2016	Our results suggest that the vitamin D-related genes RXRG and GC affect LDL-c levels.	Vitamin D	29-38	retinoid X receptor gamma	Homo sapiens	53-57
27555076-0	2016	Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients.	Vitamin D	0-9	endothelial cell specific molecule 1	Homo sapiens	36-43
27555076-3	2016	OBJECTIVE: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients.	Vitamin D	63-72	endothelial cell specific molecule 1	Homo sapiens	93-100
27555076-12	2016	A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = -.36, P = .02).	Vitamin D	73-82	endothelial cell specific molecule 1	Homo sapiens	55-62
27211082-10	2016	CONCLUSION: Calcium plus vitamin D supplementation during pregnancy interacted with polymorphisms in the VDR gene promoter region affecting postpartum bone loss.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	105-108
27685656-8	2016	Furthermore, expression changes of Vitamin D metabolism genes in VDR-/-mice were detected.	Vitamin D	35-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	65-68
27766277-3	2016	The effect of vitamin D on prostate epithelial cell proliferation and differentiation is well documented and genistein may augment this affect through inhibition of the CYP24 enzyme, which is responsible for intracellular vitamin D metabolism.	Vitamin D	222-231	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	169-174
27703587-2	2016	Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	59-78
27703587-2	2016	Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	80-83
27178987-1	2016	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney.	Vitamin D	107-116	fibroblast growth factor 23	Homo sapiens	0-27
27178987-1	2016	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney.	Vitamin D	107-116	fibroblast growth factor 23	Homo sapiens	29-34
27721584-1	2016	BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP).	Vitamin D	66-75	klotho	Homo sapiens	16-22
27721584-1	2016	BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP).	Vitamin D	66-75	fibroblast growth factor 23	Homo sapiens	29-56
27721584-1	2016	BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP).	Vitamin D	66-75	fibroblast growth factor 23	Homo sapiens	58-64
27269178-0	2016	Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture.	Vitamin D	0-9	interleukin 10	Homo sapiens	67-81
27269178-7	2016	In culture, vitamin D inhibited IFN-gamma production and increased IL-10 production by PBMCs.	Vitamin D	12-21	interleukin 10	Homo sapiens	67-72
27269178-9	2016	CONCLUSIONS: This study demonstrates that vitamin D modulates IFN-gamma and IL-10 production and provides a rationale for evaluating vitamin D as an immunomodulatory agent.	Vitamin D	42-51	interleukin 10	Homo sapiens	76-81
26567049-1	2016	AIM: Chronic kidney disease (CKD) is associated with an inflammation-mediated process, and the vitamin D (3) catabolizing enzyme, CYP24, is frequently overexpressed in CKD, where it may play a crucial role in kidney disease.	Vitamin D	95-104	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	130-135
27530414-5	2016	In this study, we investigated the presence of vitamin D machinery and metabolism in ADMSCs by analyzing the expression levels of vitamin D receptor (VDR), vitamin D metabolizing enzymes (CYP24A1 and CYP27B1) after in vitro stimulation with active vitamin D, calcitriol.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	130-148
27530414-5	2016	In this study, we investigated the presence of vitamin D machinery and metabolism in ADMSCs by analyzing the expression levels of vitamin D receptor (VDR), vitamin D metabolizing enzymes (CYP24A1 and CYP27B1) after in vitro stimulation with active vitamin D, calcitriol.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	150-153
27536155-1	2016	INTRODUCTION: Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	144-162
27255724-5	2016	Furthermore, we determined whether vitamin D deficiency accelerates CAD progression by increasing KPNA4 and nuclear NF-kappaB levels in EAT.	Vitamin D	35-44	karyopherin alpha 4 (importin alpha 3)	Sus scrofa	98-103
27255724-12	2016	Vitamin D deficiency caused extensive CAD progression and advanced atherosclerotic plaques, which are linked to increased KPNA4 and nuclear NF-kappaB levels in the EAT.	Vitamin D	0-9	karyopherin alpha 4 (importin alpha 3)	Sus scrofa	122-127
27255724-14	2016	Vitamin D deficiency accelerates CAD progression at least, in part, through enhanced chronic inflammation of EAT by upregulation of KPNA4, which enhances NF-kappaB activation.	Vitamin D	0-9	karyopherin alpha 4 (importin alpha 3)	Sus scrofa	132-137
27456065-0	2016	Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-beta/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation.	Vitamin D	0-9	toll-like receptor 7	Mus musculus	121-141
27294600-1	2016	To develop strong vitamin D receptor (VDR) antagonists and reveal their antagonistic mechanism, we designed and synthesized vitamin D analogues with bulky side chains based on the "active antagonist" concept in which antagonist prevents helix 12 (H12) folding.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	38-41
27327272-0	2016	Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	54-57
27327272-0	2016	Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.	Vitamin D	13-22	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	117-122
27327272-1	2016	Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	148-166
27327272-1	2016	Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	168-171
27649525-2	2016	The enzyme that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1, likewise is widely expressed in many cells of the body.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	75-78
27191351-1	2016	PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes and osteoblasts that regulates phosphorus and vitamin D homeostasis.	Vitamin D	137-146	fibroblast growth factor 23	Homo sapiens	19-46
27191351-1	2016	PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes and osteoblasts that regulates phosphorus and vitamin D homeostasis.	Vitamin D	137-146	fibroblast growth factor 23	Homo sapiens	48-53
27219044-4	2016	FGF-23 acts to counter-regulate the effects of vitamin D on innate immunity and cardiovascular responses.	Vitamin D	47-56	fibroblast growth factor 23	Homo sapiens	0-6
27219044-5	2016	FGF-23 is ectopically expressed along with alpha-Kl in activated macrophages, creating a proinflammatory paracrine signaling pathway that counters the antiinflammatory actions of vitamin D.	Vitamin D	179-188	fibroblast growth factor 23	Homo sapiens	0-6
27219044-9	2016	SUMMARY: FGF-23 participates in a bone-kidney axis regulating mineral homeostasis, proinflammatory paracrine macrophage signaling pathways, and in a bone-cardio-renal axis regulating hemodynamics that counteract the effects of vitamin D.	Vitamin D	227-236	fibroblast growth factor 23	Homo sapiens	9-15
27399065-9	2016	Levels of cytochrome P450 (CYP) 27A1 were significantly decreased, whereas levels of CYP24A1 were significantly elevated in cirrhotic patients.These results suggest that decreasing vitamin D levels are likely to be a result, rather than a cause, of liver dysfunction and irrespective of HBV viral load.	Vitamin D	181-190	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	85-92
26466946-0	2016	The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	98-101
26466946-5	2016	Finally, CYP24A1 was highly induced by the active form of vitamin D and its expression correlated with the expression of VDR in LCLs but neither the MS-associated variant in the region (rs2248359) nor any other variant located in 1 Mb around CYP24A1 was associated with its expression.	Vitamin D	58-67	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	9-16
26466946-5	2016	Finally, CYP24A1 was highly induced by the active form of vitamin D and its expression correlated with the expression of VDR in LCLs but neither the MS-associated variant in the region (rs2248359) nor any other variant located in 1 Mb around CYP24A1 was associated with its expression.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	121-124
27362433-7	2016	We confirmed that vitamin D increased mRNA and protein expression of endogenous nephrin in cultivated glomeruli.	Vitamin D	18-27	nephrosis 1, nephrin	Mus musculus	80-87
27408766-0	2016	Clinical and genetic findings in a Chinese family with VDR-associated hereditary vitamin D-resistant rickets.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	55-58
28394106-3	2016	Almost all tissues possess vitamin D receptor (VDR).The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	47-50
28394106-3	2016	Almost all tissues possess vitamin D receptor (VDR).The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	69-72
28394106-3	2016	Almost all tissues possess vitamin D receptor (VDR).The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	69-72
27184015-9	2016	Low serum vitamin D levels are associated with a higher prevalence of TPO antibodies, but intervention studies with extra vitamin D have not been done yet.	Vitamin D	10-19	thyroid peroxidase	Homo sapiens	70-73
27337485-6	2016	Prominent here is the vitamin D-dependent antimicrobial pathway common to human macrophages activated by innate and acquired immune responses, mediated by antimicrobial peptides, e.g., cathelicidin, through an interleukin-15- and interleukin-32-dependent common pathway that is necessary for macrophage killing of M. tuberculosis in vitro.	Vitamin D	22-31	interleukin 15	Homo sapiens	210-225
26991835-2	2016	The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	91-109
26991835-2	2016	The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	111-114
27186560-0	2016	Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease: An open-labeled randomized controlled trial.	Vitamin D	0-9	thyroid peroxidase	Homo sapiens	34-52
27186560-2	2016	This study aimed to evaluate the impact of Vitamin D supplementation on thyroid autoimmunity (thyroid peroxidase antibody [TPO-Ab] titers) in patients with newly diagnosed AITD in a randomized controlled trial.	Vitamin D	43-52	thyroid peroxidase	Homo sapiens	94-112
27186560-2	2016	This study aimed to evaluate the impact of Vitamin D supplementation on thyroid autoimmunity (thyroid peroxidase antibody [TPO-Ab] titers) in patients with newly diagnosed AITD in a randomized controlled trial.	Vitamin D	43-52	thyroid peroxidase	Homo sapiens	123-126
27186560-15	2016	CONCLUSION: Vitamin D supplementation in AITD may have a beneficial effect on autoimmunity as evidence by significant reductions in TPO-Ab titers.	Vitamin D	12-21	thyroid peroxidase	Homo sapiens	132-135
26631034-3	2016	Data from a case-control study of breast cancer (1037 cases and 1050 controls) were used to assess relationships between 21 polymorphisms in two vitamin D-related genes (GC and VDR) and breast cancer risk.	Vitamin D	145-154	vitamin D receptor	Homo sapiens	177-180
26893158-8	2016	Intriguingly, the anti-inflammatory effects of vitamin D metabolites were only observed in CFTR knockdown cells, which may be explained by alterations in its catabolism associated with changes in CYP24A1 expression.	Vitamin D	47-56	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	196-203
26747961-2	2016	The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR).	Vitamin D	26-35	vitamin D receptor	Homo sapiens	79-97
26747961-2	2016	The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR).	Vitamin D	26-35	vitamin D receptor	Homo sapiens	99-102
26747961-3	2016	VDR is a transcription factor located in the nuclei of target cells that mediates the genomic action of the active form of vitamin D (1,25(OH)2D3).	Vitamin D	123-132	vitamin D receptor	Homo sapiens	0-3
26747961-5	2016	The presence of VDR in female reproductive tissue suggests that vitamin D is involved in female reproduction.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	16-19
26934299-6	2016	We show that vitamin D signaling inhibits the expression of the tumor progression gene Id1, and this pathway is abrogated in vitamin D deficiency in vivo in 2 murine models of BCa.	Vitamin D	13-22	inhibitor of DNA binding 1, HLH protein	Mus musculus	87-90
26513524-1	2016	BACKGROUND AND AIM: The vitamin D receptor (VDR) regulates immune responses and inflammation through binding with 1,25-dihydroxyvitamin D, the active form of vitamin D.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	44-47
26694996-0	2016	Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	81-99
26694996-6	2016	Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	60-78
26694996-6	2016	Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	80-83
26694996-7	2016	Vitamin D3 was protective against vitamin D deficiency-induced cholesterol increase by maintaining the transcriptional activity of VDR and Insig-2 expression.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	131-134
26694996-8	2016	CONCLUSION: Vitamin D deficiency is associated with the increase of circulating cholesterol in the people of northern China by enhancing hepatic cholesterol biosynthesis, which was linked to the reduction of transcriptional activity of VDR.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	236-239
27483726-1	2016	Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	103-121
27483726-1	2016	Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	137-140
27064335-5	2016	It is assumed that vitamin D deficiency and genetic predisposition, for example, polymorphisms of vitamin D receptor, have a great significance.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	98-116
27186331-3	2016	Vitamin-D action is mediated by the vitamin-D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	36-54
26575331-0	2016	Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.	Vitamin D	24-33	GC vitamin D binding protein	Homo sapiens	48-52
26575331-0	2016	Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.	Vitamin D	24-33	retinoid X receptor alpha	Homo sapiens	57-61
26930567-0	2016	Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus.	Vitamin D	0-9	C-X-C motif chemokine ligand 10	Homo sapiens	101-108
26911666-8	2016	CONCLUSION: Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naive CHC G4 patients treated with low cost standard therapy.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	31-34
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	60-67
26860623-7	2016	OBJECTIVE: This paper aims to provide insight into the creation of interactive eHealth apps for complex messaging, by leveraging the Safe-D case study, which involved complex messaging required to guide safe but sufficient UV exposure for vitamin D synthesis in users.	Vitamin D	239-248	cathepsin B	Homo sapiens	87-91
26476373-4	2016	A relevant number of studies support the notion that FGF23, a bone-derived hormone, not only regulates the most important mineral metabolism (MM) related factors (phosphate, parathyroid hormone, vitamin D, etc.	Vitamin D	195-204	fibroblast growth factor 23	Homo sapiens	53-58
25727561-1	2016	Vitamin D is a steroid hormone, which in active form binds to the vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	66-84
26047794-2	2016	Recently, mutations in the vitamin D catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increased sensitivity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3.	Vitamin D	27-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	94-101
26047794-2	2016	Recently, mutations in the vitamin D catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increased sensitivity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3.	Vitamin D	67-76	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	94-101
26784541-1	2016	CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites.	Vitamin D	94-103	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	0-7
26784541-1	2016	CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites.	Vitamin D	94-103	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	0-5
26893716-0	2016	Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations.	Vitamin D	28-37	BRCA1 DNA repair associated	Homo sapiens	105-110
26893716-0	2016	Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations.	Vitamin D	28-37	BRCA2 DNA repair associated	Homo sapiens	111-116
26678915-5	2016	Both vitamin D receptor (VDR) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) are expressed in several types of immune cells (i.e. antigen presenting cells, T and B cells), and thus, they are able to synthetize the bioactive form of vitamin D that modulates both the innate and adaptive immune system.	Vitamin D	5-14	vitamin D receptor	Homo sapiens	25-28
26766742-11	2016	The variant is located near CYP24A1, which encodes an enzyme involved in vitamin D metabolism.	Vitamin D	73-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	28-35
26751954-1	2016	BACKGROUND: Vitamin-D-binding protein (VDBP) is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH) vitamin D 3/VDBP complex.	Vitamin D	132-141	GC vitamin D binding protein	Homo sapiens	12-37
27195054-9	2016	In conclusion, the inflammatory cytokine TNF increases the response of keratinocytes to calcitriol through upregulation of its receptor VDR, which in turn is subject to negative feedback by the hormone accelerating the return of the keratinocyte vitamin D system to its basal activity.	Vitamin D	246-255	vitamin D receptor	Homo sapiens	136-139
26453697-2	2016	One possible explanation for this attenuation is different concentrations of bioavailable vitamin D metabolites in plasma, which are estimated with equations that include the total concentration of vitamin D binding globulin (VDBG) and haplotype-specific dissociation constants.	Vitamin D	90-99	GC vitamin D binding protein	Homo sapiens	198-224
26453697-2	2016	One possible explanation for this attenuation is different concentrations of bioavailable vitamin D metabolites in plasma, which are estimated with equations that include the total concentration of vitamin D binding globulin (VDBG) and haplotype-specific dissociation constants.	Vitamin D	90-99	GC vitamin D binding protein	Homo sapiens	226-230
27252739-4	2016	In vitamin D switch group [RLX or BP plus alfacalcidol (ALF) and then switched to RLX or BP plus ELD, n=215], the replacing ALF with ELD further and significantly decreased TRACP-5b and tertile analyses based on baseline values were significantly decreased far more in the highest, compared with the lowest tertile in the ELD+RLX and ELD+BP groups.	Vitamin D	3-12	acid phosphatase 5, tartrate resistant	Homo sapiens	173-181
27012053-4	2016	Therefore, the elevated expression of FGF-23 may play a crucial role in defining the immune response to vitamin D and this, in turn, may be a key determinant of infection in patients.	Vitamin D	104-113	fibroblast growth factor 23	Homo sapiens	38-44
26646255-9	2016	Vitamin-D and estradiol 17-beta upregulated VDR expression.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	44-47
26646255-12	2016	Female sex steroids and vitamin-D promoted tendon-derived cell proliferation via estrogen receptor alpha and VDR, not estrogen receptor beta.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	109-112
26488808-0	2016	Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3.	Vitamin D	0-9	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	82-88
26488808-9	2016	We also demonstrate that Elovl3 is regulated by vitamin D in vivo and tissue specifically in the sc WAT depot.	Vitamin D	48-57	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	25-31
27252860-3	2016	LEARNING POINTS: Anti-glutamic acid decarboxylase antibodies (GAD-abs) titers in young patients being previously diagnosed as type 2 diabetes (T2D) may help establish the diagnosis of latent autoimmune diabetes in adults (LADA).Sitagliptin administration in patients with LADA might prolong the insulin-free period.Vitamin D administration in patients with LADA might have a protective effect on the progression of the disease.	Vitamin D	315-324	glutamate decarboxylase 1	Homo sapiens	62-65
26220765-3	2016	Furthermore, recent data suggest that bioavailable vitamin D, which also integrates the levels of vitamin D binding proteins and albumin, could be a biologically more relevant parameter than 25(OH)D. METHODS: Measured de-seasonalized 25(OH)D3 and vitamin D binding protein and calculated bioavailable and free vitamin D were compared in the baseline serum samples of 76 patients with clinically isolated syndrome enrolled in a longitudinal observational study and in 76 age- and sex-matched healthy controls (HC).	Vitamin D	51-60	GC vitamin D binding protein	Homo sapiens	98-123
27764518-11	2016	However, a significant increase in the MOG and CNPase expression was seen in vitamin D injected group as compared to SHAM and control groups.	Vitamin D	77-86	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	47-53
27764518-12	2016	It is concluded that vitamin D plays a role in the process of remyelination by increasing MOG and CNPase expression in the cortex.	Vitamin D	21-30	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	98-104
27958635-1	2016	OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy.	Vitamin D	171-180	vitamin D receptor	Homo sapiens	12-30
27958635-1	2016	OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy.	Vitamin D	171-180	vitamin D receptor	Homo sapiens	32-35
27958635-1	2016	OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy.	Vitamin D	171-180	vitamin D receptor	Homo sapiens	141-144
27355663-1	2016	BACKGROUND: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates the homeostasis of phosphate and vitamin D.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	12-39
27355663-1	2016	BACKGROUND: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates the homeostasis of phosphate and vitamin D.	Vitamin D	122-131	fibroblast growth factor 23	Homo sapiens	41-46
26522682-0	2016	Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-gamma expression in nonobese Type 2 diabetic rats.	Vitamin D	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	111-121
26522682-11	2016	In conclusion, vitamin D deficiency resulted in the dysregulation of glucose metabolism in GK rats by simultaneously increasing insulin resistance by decreasing adipose PPAR-gamma expression and deteriorating beta-cell function and mass.	Vitamin D	15-24	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	169-179
25777538-6	2016	The effect of dietary vitamin D on colonic Wnt signaling was investigated in mice fed either with 100 IU or 2500 IU vitamin D/kg diet.	Vitamin D	22-31	wingless-type MMTV integration site family, member 5A	Mus musculus	43-46
25777538-12	2016	In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased.	Vitamin D	39-48	wingless-type MMTV integration site family, member 5A	Mus musculus	74-79
25777538-12	2016	In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased.	Vitamin D	39-48	catenin (cadherin associated protein), beta 1	Mus musculus	118-130
25777538-12	2016	In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased.	Vitamin D	39-48	catenin (cadherin associated protein), beta 1	Mus musculus	157-169
26058412-8	2016	However, vitamin D could reverse the inhibition of both VDR and LL-37 [1.5-fold increase (P = 0.001) and 2000-fold increase (P &lt; 0.001) respectively].	Vitamin D	9-18	vitamin D receptor	Homo sapiens	56-59
26058412-10	2016	CONCLUSIONS: When vitamin D levels were low, bacteria inhibited VDR and LL-37 responses in peritoneal macrophages as a mechanism to evade antibacterial defence.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	64-67
26058412-11	2016	Vitamin D supplementation could up-regulate peritoneal macrophage VDR and LL-37 expressions, which resulted in an enhanced immunological defence against SBP in patients with cirrhosis and ascites.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	66-69
27298518-0	2016	Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy.	Vitamin D	9-18	interleukin 10	Homo sapiens	79-84
27298518-7	2016	Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation (p = 0.006).	Vitamin D	9-18	interleukin 10	Homo sapiens	55-60
27298518-10	2016	In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.	Vitamin D	49-58	interleukin 10	Homo sapiens	130-135
26602143-1	2016	Patients with significant proteinuria represent a unique population with respect to vitamin D status due to the urinary losses of vitamin D-binding protein (DBP) to which &gt;99 % of circulating 25-hydroxy vitamin D (25(OH)D) is bound.	Vitamin D	84-93	GC vitamin D binding protein	Homo sapiens	130-155
26686848-3	2016	Recent studies have demonstrated that vitamin D, through its receptor (VDR), is able to regulate the immune balance and suppress the autoimmunity process, being a potential target in autoimmune diseases.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	71-74
26567701-1	2016	The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting.	Vitamin D	194-203	fibroblast growth factor 23	Homo sapiens	65-70
26904920-1	2016	Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	0-18
26904920-1	2016	Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	20-23
26366751-4	2016	Vitamin D receptor activation using a vitamin D responsive element-mediated cytochrome P450 3A4 reporter gene assay was investigated in Caco-2 cells transfected with human vitamin D receptor.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	0-18
26446551-5	2016	However, plasma levels of vitamin D binding protein isotype 1 and alpha1-antitrypsin isotypes 2, 3 and 4 were significantly decreased in BRCA2 mutation carriers compared to controls.	Vitamin D	26-35	BRCA2 DNA repair associated	Homo sapiens	137-142
26827954-2	2016	This activity is commonly attributed to direct binding of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3, calcitriol], the hormonally active form of vitamin D, to the vitamin D receptor (VDR).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	168-186
26827954-2	2016	This activity is commonly attributed to direct binding of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3, calcitriol], the hormonally active form of vitamin D, to the vitamin D receptor (VDR).	Vitamin D	77-86	vitamin D receptor	Homo sapiens	188-191
26827954-3	2016	More recently, calcitriol and VDR have been shown to control the expression of genes associated with cellular proliferation and differentiation in a wide variety of cells, suggesting more extensive biological activities for the vitamin D system.	Vitamin D	228-237	vitamin D receptor	Homo sapiens	30-33
26827958-5	2016	Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	102-120
26827958-5	2016	Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	122-125
26827958-7	2016	Androgen inhibits vitamin D-mediated induction of CYP24A1, the calcitriol-degrading enzyme, while vitamin D promotes androgen inactivation by inducing phase I monooxygenases (e.g., CYP3A4) and phase II transferases (e.g., SULT2B1b, a DHEA-sulfotransferase).	Vitamin D	18-27	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	50-57
26827962-7	2016	CYP24A1 inhibitors plus 1,25D3 can cause dose-limiting toxicity of vitamin D (hypercalcemia) in some patients.	Vitamin D	67-76	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
26441239-9	2015	Introduction of transgenes for either mouse or human VDR also normalized vitamin D metabolism in VDR null mice, whereas this metabolic pattern was unaffected by a transgene encoding a ligand binding-deficient mutant (L233S) human VDR.	Vitamin D	73-82	vitamin D receptor	Homo sapiens	53-56
26641549-8	2015	RESULTS: When treated with inactive vitamin D metabolites, HCEC produced active 1,25D3, leading to enhanced expression of the antimicrobial peptide, LL-37, dependent on VDR.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	169-172
26476188-4	2015	Analysis of 24 vitamin D analogs, bearing similar molecular structures complexed with Vitamin D Receptor enabled the design of new agonists forming all advantageous interaction to the receptor, coded TB1, TB2, TB3 and TB4.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	86-104
26588476-1	2015	Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphate (Pi) and vitamin D homeostasis.	Vitamin D	80-89	fibroblast growth factor 23	Mus musculus	0-27
26588476-1	2015	Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphate (Pi) and vitamin D homeostasis.	Vitamin D	80-89	fibroblast growth factor 23	Mus musculus	29-34
26540116-6	2015	VDR variant FokI associated with higher vitamin D levels in both groups.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	0-3
26404398-1	2015	Bioactive vitamin D is a steroid hormone transported in blood via the vitamin D binding protein (DBP).	Vitamin D	10-19	GC vitamin D binding protein	Homo sapiens	70-95
26364161-2	2015	Beyond VDR, the biologic effects of vitamin D are mediated by the vitamin D-binding protein (DBP), a key protein in vitamin D metabolism.	Vitamin D	36-45	GC vitamin D binding protein	Homo sapiens	66-91
26273098-2	2015	Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	0-27
26273098-2	2015	Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	29-35
26677265-3	2015	Vitamin D has stimulatory effects on melanocytes and acts through its nuclear Vitamin D receptor (VDR) on target cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	78-96
26677265-3	2015	Vitamin D has stimulatory effects on melanocytes and acts through its nuclear Vitamin D receptor (VDR) on target cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	98-101
26332676-1	2015	Vitamin D-binding protein (DBP) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D.	Vitamin D	185-194	GC vitamin D binding protein	Homo sapiens	0-25
26424141-10	2015	While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (FGF-23) levels, which may be detrimental in dialysis patients.	Vitamin D	16-25	fibroblast growth factor 23	Homo sapiens	96-123
26424141-10	2015	While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (FGF-23) levels, which may be detrimental in dialysis patients.	Vitamin D	16-25	fibroblast growth factor 23	Homo sapiens	125-131
27025071-0	2015	[The history of creation and study of vitamin D medicines in the Laboratory of Medical Biochemistry of Palladin Institute of Biochemistry of NAS of Ukraine for 1990-2015].	Vitamin D	38-47	palladin, cytoskeletal associated protein	Homo sapiens	103-111
26517870-1	2015	BACKGROUND: Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	115-133
26517870-1	2015	BACKGROUND: Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	135-138
26291576-5	2015	In innate immunity, vitamin D promotes production of cathelicidin and beta-defensin 2 and enhances the capacity for autophagy via toll-like receptor activation as well as affects complement concentrations.	Vitamin D	20-29	defensin beta 4B	Homo sapiens	70-85
26291576-7	2015	Vitamin D also increases T helper (Th) 2 cytokine production and the efficiency of Treg lymphocytes but suppresses the secretion of Th1 and Th17 cytokines.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	132-135
26770399-7	2015	Both the mean fluorescence intensity and the positive percentage of monocytes TLR4 in the vitamin D group were significantly lower compared to the placebo group, as well as the concentrations of secreted TNF-alpha, IL-6, and IL-1, while the concentration of IL-10 was higher.	Vitamin D	90-99	interleukin 10	Homo sapiens	258-263
26010336-1	2015	Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	92-110
26010336-1	2015	Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	112-115
26312598-11	2015	A 6.7-fold increased odds of AMD (95% CI, 1.6-28.2) was observed among women with deficient vitamin D status (25[OH]D &lt;12 ng/mL) and 2 risk alleles for CFH Y402H (SI for additive interaction, 1.4; 95% CI, 1.1-1.7; P for multiplicative interaction = .25).	Vitamin D	92-101	complement factor H	Homo sapiens	155-158
26312598-14	2015	CONCLUSIONS AND RELEVANCE: In this study, the odds of AMD were highest in those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function.	Vitamin D	202-211	complement factor H	Homo sapiens	139-142
26312598-14	2015	CONCLUSIONS AND RELEVANCE: In this study, the odds of AMD were highest in those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function.	Vitamin D	202-211	complement factor I	Homo sapiens	147-150
26448018-1	2015	To investigate whether single nucleotide polymorphisms (SNPs) within 4 representative genes (VDR, GC, CYP2R1, and CYP24A1) encoding the core proteins involved in vitamin D production, degradation, and ligand-dependent signaling pathway are associated with gestational diabetes mellitus (GDM) in a Chinese population.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	93-96
26448018-1	2015	To investigate whether single nucleotide polymorphisms (SNPs) within 4 representative genes (VDR, GC, CYP2R1, and CYP24A1) encoding the core proteins involved in vitamin D production, degradation, and ligand-dependent signaling pathway are associated with gestational diabetes mellitus (GDM) in a Chinese population.	Vitamin D	162-171	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-121
26904855-3	2015	Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates, and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	173-191
26904855-3	2015	Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates, and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	193-196
26422470-1	2015	Hereditary 1, 25-dihydroxyvitamin D-resistant rickets (HVDRR), a rare recessive disease, is caused by mutation in the VDR gene encoding the vitamin D receptor leading to the resistance to vitamin D.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	56-59
26489816-4	2015	Here, we describe a case of hypersensitivity to vitamin D by mutation of CYP24A1.	Vitamin D	48-57	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	73-80
25920689-2	2015	Racial differences in fracture risk may be related to differences in bioavailable vitamin D due to single nucleotide polymorphism (SNP) variations in the vitamin D binding protein (DBP).	Vitamin D	82-91	GC vitamin D binding protein	Homo sapiens	154-179
26071405-0	2015	1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D.	Vitamin D	14-23	tryptophan hydroxylase 2	Homo sapiens	52-76
26458343-1	2015	BACKGROUND &amp; OBJECTIVES: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS).	Vitamin D	68-77	vitamin D receptor	Homo sapiens	33-51
26458343-1	2015	BACKGROUND &amp; OBJECTIVES: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS).	Vitamin D	68-77	vitamin D receptor	Homo sapiens	53-56
26188623-0	2015	Vitamin D supplementation up-regulates IL-6 and IL-17A gene expression in multiple sclerosis patients.	Vitamin D	0-9	interleukin 17A	Homo sapiens	48-54
26188623-3	2015	The aim of this study was to investigate the vitamin D effects on the expression level of IL-6 and IL-17A in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients.	Vitamin D	45-54	interleukin 17A	Homo sapiens	99-105
26188623-5	2015	Significant up-regulation of IL-6 and IL-17A gene expression was shown under vitamin D treatment.	Vitamin D	77-86	interleukin 17A	Homo sapiens	38-44
26184408-2	2015	By binding the active vitamin D hormone to the vitamin D receptor (VDR), it acts as a nuclear transcription factor (Bouillon et al., Endocr Rev 29(6):726-776, 2008).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	67-70
26184408-3	2015	The discovery that almost all tissues and cells in the body express the VDR and that several tissues possess the enzymatic capability to convert 25-hydroxyvitamin D (25(OH)-D3; cholecalciferol) to the active form, suggests that vitamin D fulfills various extra-osseous functions (Bouillon et al., Endocr Rev 29(6):726-776, 2008; Holick, N Engl J Med 357(3):266-281, 2007).	Vitamin D	155-164	vitamin D receptor	Homo sapiens	72-75
26093339-7	2015	By the kappa test, both IDS-EIA and DiaSorin-RIA were in acceptable agreement with LC-MS/MS in the assessment of vitamin D deficiency and insufficiency.	Vitamin D	113-122	iduronate 2-sulfatase	Homo sapiens	24-27
26347716-3	2015	On that account, active vitamin D, the ligand of VDR, is used as an adjuvant therapy to control infection, slow down progression of chronic kidney diseases, and cancer chemotherapy.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	49-52
26141804-6	2015	We also discuss the emergence of "new" genetic diseases such as mutations in the 24-hydroxylase (CYP24A1) gene inducing neonatal hypercalcemia and nephrocalcinosis: we believe that before prescribing conventional vitamin D supplementation as recommended by the national guidelines, pediatricians should quickly rule out a potential genetic abnormality in phosphate/calcium metabolism (namely a history of lithiasis or hypercalcemia) that would lead to further biological investigations.	Vitamin D	213-222	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	97-104
25740667-4	2015	The purpose of the study is to find out the Th1/Th2 status by estimating TNF-alpha (Th1 marker) and IL-4 (Th2 marker) in ovarian cancer cases and controls and to correlate these with serum vitamin D levels.	Vitamin D	189-198	negative elongation factor complex member C/D	Homo sapiens	44-47
25740667-11	2015	CONCLUSIONS: Low vitamin D levels promotes Th1 activity increasing TNF-alpha levels and inhibits Th2 activity decreasing IL-4 levels in ovarian cancer.	Vitamin D	17-26	negative elongation factor complex member C/D	Homo sapiens	43-46
25736056-8	2015	Four of these 11 genes (CYP24A1, CLMN, EFTUD1, and SERPINB1) were also identified as 1,25D responsive in human breast tumor explants, suggesting that this gene signature may prove useful as a biomarker of vitamin D exposure in breast tissue.	Vitamin D	205-214	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	24-31
25517289-1	2015	OBJECTIVE: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	80-83
26288665-4	2015	Sophisticated experimental techniques have allowed detection of the vitamin D receptor (VDR) on skeletal muscle and cerebellar tissue, which if validated in further large studies, could confirm the mechanism of vitamin D in these associations.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	88-91
25804799-2	2015	The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR).	Vitamin D	17-26	vitamin D receptor	Homo sapiens	53-71
25804799-2	2015	The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR).	Vitamin D	17-26	vitamin D receptor	Homo sapiens	73-76
26041780-8	2015	We then conducted a ChIP sequence analysis of binding sites for the vitamin D receptor (VDR) across the proximal intestine in vitamin D-sufficient normal mice treated with vehicle or 1,25(OH)2D3.	Vitamin D	68-77	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	88-91
26193703-1	2015	BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population.	Vitamin D	126-135	fibroblast growth factor 23	Homo sapiens	22-49
26193703-1	2015	BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population.	Vitamin D	126-135	fibroblast growth factor 23	Homo sapiens	51-56
26162848-0	2015	Vitamin D status among adults in Germany--results from the German Health Interview and Examination Survey for Adults (DEGS1).	Vitamin D	0-9	delta 4-desaturase, sphingolipid 1	Homo sapiens	118-123
26162848-3	2015	With data from the "German Health Interview and Examination Survey for Adults" (DEGS1) the current situation of vitamin D status can be analysed.	Vitamin D	112-121	delta 4-desaturase, sphingolipid 1	Homo sapiens	80-85
26019137-2	2015	Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D.	Vitamin D	189-198	fibroblast growth factor 23	Homo sapiens	0-27
26019137-2	2015	Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D.	Vitamin D	189-198	fibroblast growth factor 23	Homo sapiens	29-34
26217190-10	2015	The immuno-modulatory properties of vitamin D receptor (VDR) suggest that vitamin D is an attractive and plausible candidate in spite of controversial findings.	Vitamin D	36-45	vitamin D receptor	Homo sapiens	56-59
26180726-9	2015	The physiologically active form of vitamin D, 1,25(OH)2D3, inhibits the proliferation of keloid fibroblasts, and correlations between vitamin D receptor polymorphisms, such as the TaqI CC genotype, and keloid formation have been reported.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	134-152
26149120-0	2015	Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.	Vitamin D	0-9	7-dehydrocholesterol reductase	Homo sapiens	89-94
26149120-0	2015	Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.	Vitamin D	0-9	NAD synthetase 1	Homo sapiens	95-102
26149120-12	2015	: 361-31.357), while DHCR7/NADSYN1-rs12785878 was significantly associated with the presence of vitamin D deficiency in the Kazak ethnic population (P=0.011, OR=2.442, 95%C.I.	Vitamin D	96-105	7-dehydrocholesterol reductase	Homo sapiens	21-26
26149120-12	2015	: 361-31.357), while DHCR7/NADSYN1-rs12785878 was significantly associated with the presence of vitamin D deficiency in the Kazak ethnic population (P=0.011, OR=2.442, 95%C.I.	Vitamin D	96-105	NAD synthetase 1	Homo sapiens	27-34
26149120-16	2015	Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations.	Vitamin D	84-93	7-dehydrocholesterol reductase	Homo sapiens	39-44
26149120-16	2015	Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations.	Vitamin D	84-93	NAD synthetase 1	Homo sapiens	45-52
26131357-5	2015	FGF23 can also fine-tune vitamin D homeostasis by suppressing renal expression of 1-alpha hydroxylase (1alpha(OH)ase).	Vitamin D	25-34	fibroblast growth factor 23	Homo sapiens	0-5
25536521-1	2015	The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	147-165
25536521-1	2015	The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle.	Vitamin D	18-27	vitamin D receptor	Homo sapiens	167-170
25708797-1	2015	UNLABELLED: Adding to the debate around vitamin D"s effects on skeletal health, we report the long-term follow-up of two patients with severe vitamin D receptor mutations, who had normal bone mass acquisition and normalization of calcemia around puberty, suggesting that vitamin D might not be essential for skeletal health in adulthood.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	142-160
25708797-3	2015	Individuals bearing homozygous vitamin D receptor (VDR) defects present with severe hypocalcemic rickets in early infancy due to vitamin D resistance.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	51-54
25708797-13	2015	The normalization of calcemia and normal bone mass acquisition despite a permanently dysfunctional VDR suggest that vitamin D might not be essential for skeletal health in adulthood.	Vitamin D	116-125	vitamin D receptor	Homo sapiens	99-102
26035242-11	2015	In one of the publications, it was also found that vitamin D binding protein (VDBP) has a molecular similarity to anti-sperm antibodies, and another one concluded that both low (&lt;50 nmol/L) and high (&gt;125 nmol/L) concentration of vitamin D are associated with decreased number and quality of spermatozoa in semen.	Vitamin D	51-60	GC vitamin D binding protein	Homo sapiens	78-82
25809484-2	2015	This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	79-82
25809484-2	2015	This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression.	Vitamin D	140-149	retinoid X receptor alpha	Homo sapiens	120-123
25873367-1	2015	One variable that may affect the ability of vitamin D to reduce colon cancer risk is the expression of its high-affinity receptor, VDR.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	131-134
25873367-11	2015	Determining the mechanisms of VDR regulation in colon neoplasms may significantly enhance our ability to use vitamin D as a cancer prevention agent.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	30-33
25813397-8	2015	We found that the vitamin D-treated mice had lower expression levels of caspase-3 than the vehicle-treated mice.	Vitamin D	18-27	caspase 3	Mus musculus	72-81
24996526-1	2015	Fibroblast growth factor 23 (FGF23), a central regulator of phosphate and vitamin D metabolism, is mainly produced by osteocytes in bone and exerts its effects on distant organs.	Vitamin D	74-83	fibroblast growth factor 23	Mus musculus	0-27
24996526-1	2015	Fibroblast growth factor 23 (FGF23), a central regulator of phosphate and vitamin D metabolism, is mainly produced by osteocytes in bone and exerts its effects on distant organs.	Vitamin D	74-83	fibroblast growth factor 23	Mus musculus	29-34
25910558-0	2015	Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis.	Vitamin D	0-9	matrix metallopeptidase 9	Homo sapiens	68-94
25910558-3	2015	The aim of this study was to understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp-derived fibroblasts.	Vitamin D	52-61	matrix metallopeptidase 9	Homo sapiens	202-207
25910558-10	2015	The inhibitory effect of vitamin D derivatives on MMP-2 and MMP-9 secretion could potentiate their application in pharmacotherapy of Taiwanese CRSwNP patients.	Vitamin D	25-34	matrix metallopeptidase 9	Homo sapiens	60-65
25998734-5	2015	This phenotypic stability role is facilitated through the ability of vitamin D to increase the expression of both Nrf2 and the anti-ageing protein Klotho, which are also major regulators of Ca(2+) and redox signalling.	Vitamin D	69-78	klotho	Homo sapiens	147-153
25898185-5	2015	Independent risk factors for vitamin D deficiency in HIV + patients included black race (OR 3.24, 95% CI 2.28-4.60), winter season (OR 1.39, 95% CI 1.05-1.84) and higher GFR (OR 1.01, CI 1.00-1.01); increasing age (OR 0.98, 95% CI 0.95-0.98), and tenofovir use (OR 0.72, 95% CI 0.54-0.96) were associated with less vitamin D deficiency.	Vitamin D	29-38	Rap guanine nucleotide exchange factor 5	Homo sapiens	170-173
25910066-15	2015	This VDR haplotype could be useful in identifying individuals who benefit most from vitamin D chemoprevention.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	5-8
26106480-1	2015	We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	52-55
25881523-2	2015	In recent years, the discovery of vitamin D-metabolizing enzymes and vitamin D receptor (VDR) in the lungs and various cells of the immune system has led to numerous studies conducted to evaluate its role in respiratory functions and, in particular, upper respiratory tract infections (URTIs).	Vitamin D	34-43	vitamin D receptor	Homo sapiens	89-92
25636720-5	2015	Other etiologies of vitamin D induced hypercalcemia include hyperparathyroidism, granulomatous malignancies like sarcoidosis and mutations in the CYP24A1 gene.	Vitamin D	20-29	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	146-153
25644204-14	2015	Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency.	Vitamin D	0-9	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-37
25801892-2	2015	Recent studies highlight that vitamin D may exert actions on T-cells, inhibiting Th1 and Th17 response and enhancing Th2 and T-regulatory (T-reg) function.	Vitamin D	30-39	negative elongation factor complex member C/D	Homo sapiens	81-84
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	negative elongation factor complex member C/D	Homo sapiens	149-152
25852682-5	2015	Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.	Vitamin D	83-92	negative elongation factor complex member C/D	Homo sapiens	157-160
25595352-0	2015	Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236).	Vitamin D	20-29	vitamin D receptor	Homo sapiens	131-134
25595352-2	2015	The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	189-207
25595352-2	2015	The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	209-212
25595352-6	2015	CONCLUSION: In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	78-81
25680585-0	2015	Interleukin-10 but not transforming growth factor-beta1 gene expression is up-regulated by vitamin D treatment in multiple sclerosis patients.	Vitamin D	91-100	interleukin 10	Homo sapiens	0-14
25680585-4	2015	Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) genes in MS patients.	Vitamin D	53-62	interleukin 10	Homo sapiens	94-108
25680585-4	2015	Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) genes in MS patients.	Vitamin D	53-62	interleukin 10	Homo sapiens	110-115
25560187-1	2015	The vitamin D receptor (VDR) is a mediator for the cellular effects of vitamin D and interacts with other cell signaling pathways that influence cancer development.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
25575651-1	2015	A method for quantitative analysis of vitamin D (both D2 and D3) and its main metabolites - monohydroxylated vitamin D (25-hydroxyvitamin D2 and 25-hydroxyvitamin D3) and dihydroxylated metabolites (1,25-dihydroxyvitamin D2, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3) in human serum is here reported.	Vitamin D	38-47	immunoglobulin heavy diversity 2-15	Homo sapiens	54-63
25482012-0	2015	The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D.	Vitamin D	93-102	BCL6 transcription repressor	Homo sapiens	30-34
25482012-1	2015	The vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the transcription factor vitamin D receptor (VDR) and therefore a direct regulator of transcription.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	120-138
25482012-1	2015	The vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the transcription factor vitamin D receptor (VDR) and therefore a direct regulator of transcription.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	140-143
25479835-10	2015	These findings suggest treatment with vitamin D compounds results in sustained increases in VDR in human skeletal muscle.	Vitamin D	38-47	vitamin D receptor	Homo sapiens	92-95
25716805-2	2015	Most of vitamin D actions mediate expression of target genes regulated by nuclear vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D receptor	Homo sapiens	82-100
25716805-2	2015	Most of vitamin D actions mediate expression of target genes regulated by nuclear vitamin D receptor (VDR).	Vitamin D	8-17	vitamin D receptor	Homo sapiens	102-105
25716806-1	2015	Cross talks among vitamin D endocrine system, PTH and FGF23].	Vitamin D	18-27	fibroblast growth factor 23	Homo sapiens	54-59
25716810-4	2015	Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	111-129
25716810-4	2015	Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	131-134
25716811-3	2015	Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	57-75
25716811-3	2015	Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	77-80
25716814-3	2015	The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 [1,25 (OH) 2D3], regulates numerous physiological and pharmacological processes, including bone and calcium homeostasis, cellular growth and differentiation, immunity, and cardiovascular function, through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	281-299
25716814-3	2015	The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 [1,25 (OH) 2D3], regulates numerous physiological and pharmacological processes, including bone and calcium homeostasis, cellular growth and differentiation, immunity, and cardiovascular function, through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	301-304
25370319-0	2015	Low Vitamin D Status is Associated with Increased Thyrotropin-Receptor Antibody Titer in Graves Disease.	Vitamin D	4-13	thyroid stimulating hormone receptor	Homo sapiens	50-70
25370324-0	2015	Vitamin D binding protein gene polymorphism as a risk factor for vitamin D deficiency in Thais.	Vitamin D	65-74	GC vitamin D binding protein	Homo sapiens	0-25
25667460-6	2015	All cell lines demonstrated large increases in CYP24A1 mRNA levels under vitamin D treatment but there was little change in CYP27B1 or VDR mRNA levels.	Vitamin D	73-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	47-54
25667460-8	2015	This could be due to large inactivation of vitamin D by CYP24A1 or by another mechanism.	Vitamin D	43-52	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	56-63
25645983-0	2015	Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps.	Vitamin D	0-9	C-C motif chemokine ligand 5	Homo sapiens	49-55
25645983-12	2015	Therefore, the inhibitory effect of vitamin D derivatives on eotaxin and RANTES secretion might shed light not only on the disease mechanism, but also on the potential use of vitamin D in pharmacotherapy of Taiwanese patients with CRSwNP.	Vitamin D	36-45	C-C motif chemokine ligand 5	Homo sapiens	73-79
25597001-5	2015	End-stage renal disease (ESRD) is also associated with a decrease in vitamin D activity by mechanisms including the increase of plasma phosphate concentration, secretion of FGF-23 and decrease in 1alpha-hydroxylase activity.	Vitamin D	69-78	fibroblast growth factor 23	Homo sapiens	173-179
25270396-2	2015	Elevated fibroblast growth factor (FGF)-23 in cyclosporine A (CsA) users with SLE are associated with decreased active vitamin D and osteocalcin.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	9-42
25785055-7	2015	The salivary MMP 2, MMP 3, and MMP 9 levels of the patients with vitamin D and vitamin B12 treatment were lower than that in the patients without vitamin D and vitamin B12 treatment.	Vitamin D	65-74	matrix metallopeptidase 9	Homo sapiens	31-36
25527766-2	2015	In the Food with vitamin D (VitmaD) study, we showed that common genetic variants rs10741657 and rs10766197 in 25-hydroxylase (CYP2R1) and rs842999 and rs4588 in vitamin D binding protein (GC) predict 25(OH)D concentrations at late summer and after 6-mo consumption of cholecalciferol (vitamin D3)-fortified bread and milk.	Vitamin D	17-26	GC vitamin D binding protein	Homo sapiens	162-187
26078251-2	2015	Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25- dihydroxyvitamin D3 [1, 25(OH)2D], and mediates its effects.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	0-18
26078251-2	2015	Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25- dihydroxyvitamin D3 [1, 25(OH)2D], and mediates its effects.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	20-23
25773805-0	2015	Associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk and effect modifications of dietary calcium and vitamin D in a Japanese population.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	41-44
25739891-2	2015	While several studies have revealed that Fgf23 plays important roles in the regulation of phosphate and vitamin D metabolism, the additional physiological roles of Fgf23 remain unclear.	Vitamin D	104-113	fibroblast growth factor 23	Mus musculus	41-46
26000293-8	2015	There is a growing body of evidence concerning the therapeutic role of vitamin D/synthetic vitamin D receptor agonists in clinical and experimental models of inflammatory bowel disease far beyond the role of calcium homeostasis and bone metabolism.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	91-109
26000306-2	2015	However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle.	Vitamin D	34-43	vitamin D receptor	Homo sapiens	54-57
26000306-3	2015	In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	126-129
26325349-2	2015	Of significance, many immune cells are able to synthesize a biologically active form of vitamin D from circulating 25-hydroxyvitamin D with subsequent intracrine actions, and the vitamin D receptor is broadly distributed.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	179-197
26402335-2	2015	Although many VDR ligands have been developed and shown to activate VDR in vitro and in vivo, including vitamin D derivatives and non-secosteroidal compounds, a principal adverse effect of hypercalcemia has limited their clinical application.	Vitamin D	104-113	vitamin D receptor	Homo sapiens	14-17
26402335-3	2015	AREAS COVERED: We summarize recent patent activity regarding VDR ligands, including vitamin D derivatives, non-secosteroidal compounds and tissue-selective prodrugs, alongside their therapeutic applications.	Vitamin D	84-93	vitamin D receptor	Homo sapiens	61-64
25573344-1	2015	BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations in the vitamin D receptor (VDR) gene, which result in end-organ resistance to 1,25-(OH)2D3.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	113-131
25573344-1	2015	BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations in the vitamin D receptor (VDR) gene, which result in end-organ resistance to 1,25-(OH)2D3.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	53-56
25872112-2	2015	Here, we wished to analyze whether the active form of vitamin D, i.e. vitamin D3, referred to as 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] can exert GC-like proapoptotic effects on CD16-positive monocytes and thus decrease the proinflammatory potential of these cells.	Vitamin D	54-63	Fc gamma receptor IIIa	Homo sapiens	184-188
25268393-1	2015	BACKGROUND/AIMS: Low 25-hydroxyvitamin D serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC), and experimental evidence suggested a hepatoprotective role of vitamin D via interaction with hepatic vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	265-283
25268393-1	2015	BACKGROUND/AIMS: Low 25-hydroxyvitamin D serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC), and experimental evidence suggested a hepatoprotective role of vitamin D via interaction with hepatic vitamin D receptor (VDR).	Vitamin D	31-40	vitamin D receptor	Homo sapiens	285-288
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	187-194
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	vitamin D receptor	Homo sapiens	276-279
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	retinoid X receptor alpha	Homo sapiens	281-284
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	187-194
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	vitamin D receptor	Homo sapiens	276-279
25985949-5	2015	The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD).	Vitamin D	146-155	retinoid X receptor alpha	Homo sapiens	281-284
25611831-4	2015	The biologic actions of both vitamin D and its synthetic analogues are mediated by binding to the same VDR, acting on different genes.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	103-106
25611831-8	2015	Moreover, it considers that, in addition to selective/non selective activation of VDR for the prevention and treatment of SHPT, VDR could be activated in dialysis patients by native vitamin D or even low paricalcitol doses, independently of PTH levels, as some cohort studies and a recent metaanalysis have found an association between treatment with active vitamin D and decreased mortality in patients with CKD.	Vitamin D	182-191	vitamin D receptor	Homo sapiens	128-131
25611831-8	2015	Moreover, it considers that, in addition to selective/non selective activation of VDR for the prevention and treatment of SHPT, VDR could be activated in dialysis patients by native vitamin D or even low paricalcitol doses, independently of PTH levels, as some cohort studies and a recent metaanalysis have found an association between treatment with active vitamin D and decreased mortality in patients with CKD.	Vitamin D	358-367	vitamin D receptor	Homo sapiens	128-131
26068724-3	2015	The aim of this study was to elucidate which factor, FGF-23 or PTH, plays a more important role in the regulation of vitamin D metabolites in subjects with estimated glomerular filtration (eGFR) &gt;=60 ml/min/1.73 m(2).	Vitamin D	117-126	fibroblast growth factor 23	Homo sapiens	53-59
26068724-7	2015	CONCLUSIONS: This study demonstrated that, even in subjects with eGFR &gt;=60 ml/min/1.73 m(2), FGF-23 might play an important role in the regulation of vitamin D metabolism.	Vitamin D	153-162	fibroblast growth factor 23	Homo sapiens	96-102
26068724-8	2015	In addition to the established role of PTH, the association between FGF-23 and indices of vitamin D metabolism suggested the potential role of FGF-23 on phosphate metabolism in such patients.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	68-74
26401986-0	2015	Short-term effect of high-dose vitamin D on the level of interleukin 10 in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial.	Vitamin D	31-40	interleukin 10	Homo sapiens	57-71
26401986-4	2015	OBJECTIVE: This study compared the effects of high-dose vitamin D on interleukin 10 (IL-10) levels in MS patients in a double-blind, randomized clinical trial.	Vitamin D	56-65	interleukin 10	Homo sapiens	69-83
26401986-4	2015	OBJECTIVE: This study compared the effects of high-dose vitamin D on interleukin 10 (IL-10) levels in MS patients in a double-blind, randomized clinical trial.	Vitamin D	56-65	interleukin 10	Homo sapiens	85-90
26401986-10	2015	The IL-10 level increased significantly after receiving high-dose vitamin D for 3 months (beta = 0.737, p = 0.015 and R2 = 0.91).	Vitamin D	66-75	interleukin 10	Homo sapiens	4-9
26022923-3	2015	Klotho (KL) serves as a co-receptor for fibroblast growth factor 23 (FGF23), and functions in vitamin D metabolism.	Vitamin D	94-103	klotho	Homo sapiens	0-6
26022923-3	2015	Klotho (KL) serves as a co-receptor for fibroblast growth factor 23 (FGF23), and functions in vitamin D metabolism.	Vitamin D	94-103	klotho	Homo sapiens	8-10
25378147-2	2015	Furthermore, vitamin D production and supplementation have been shown to exert protective effects via an unknown signaling mechanism involving the vitamin D receptor (VDR) in several diseases and cancer types, including skin cancer.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	147-165
25378147-2	2015	Furthermore, vitamin D production and supplementation have been shown to exert protective effects via an unknown signaling mechanism involving the vitamin D receptor (VDR) in several diseases and cancer types, including skin cancer.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	167-170
25470522-8	2015	Moreover, osteocalcin also influences phosphate metabolism via osteocyte-derived FGF23 (which targets the kidneys and parathyroid glands to control phosphate reabsorption and metabolism of vitamin D).	Vitamin D	189-198	fibroblast growth factor 23	Homo sapiens	81-86
25549329-9	2014	Adjustment for PD cell CD14/CD45 expression using a mixed linear statistical model also revealed increased expression of CAMP (mRNA in PD cells and protein in effluent) in vitamin D-supplemented patients.	Vitamin D	172-181	protein tyrosine phosphatase receptor type C	Homo sapiens	28-32
25260641-10	2014	Vitamin D levels were significantly associated with marine fatty acids and weakly associated with PUFA ratios.	Vitamin D	0-9	pumilio RNA binding family member 3	Homo sapiens	98-102
25209438-13	2014	Bone loss might be attributed to impaired calcium absorption caused by decreased activation of vitamin D-dependent calcium absorption mechanisms mediated by heat-shock protein 90beta and TRPV6.	Vitamin D	95-104	transient receptor potential cation channel subfamily V member 6	Homo sapiens	187-192
25355154-3	2014	Although major targets of vitamin D action are skeletal system and mineral metabolism, vitamin D receptor is ubiquitously expressed in many tissues.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	87-105
25165393-3	2014	25D is the major circulating form of vitamin D and renal reabsorption of the 25D-vitamin D-binding protein (DBP) complex via megalin-mediated endocytosis is believed to determine whether 25D can be activated to 1,25-dihydroxycholecalciferol (1,25D) or returned to circulation.	Vitamin D	37-46	D-box binding PAR bZIP transcription factor	Rattus norvegicus	108-111
25070320-2	2014	OBJECTIVE: We investigated whether 41 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR, and CASR) are associated with [25(OH)D] or modify the increase in [25(OH)D] from vitamin D3 supplementation.	Vitamin D	90-99	7-dehydrocholesterol reductase	Homo sapiens	131-136
23911725-3	2014	Classically, transcriptional regulation by the VDR, similar to other nuclear receptors, has been characterized by its capacity to recognize high affinity cognate vitamin D response elements (VDREs), located in the regulatory regions of target genes.	Vitamin D	162-171	vitamin D receptor	Homo sapiens	47-50
24361583-2	2014	During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively.	Vitamin D	55-64	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	142-149
24464689-8	2014	The prevalence of vitamin D deficiency was significantly higher in individuals with high anti-TPO than those in lower levels (87.5 vs. 59.5 %, p = 0.001).	Vitamin D	18-27	thyroid peroxidase	Homo sapiens	94-97
24859502-1	2014	OBJECTIVE: To study the vitamin D receptor (VDR) gene in five Egyptian patients with severe rickets and the clinical features of hereditary vitamin D-resistant rickets, including hypocalcemia, hypophosphatemia, total alopecia, and elevated serum levels of 1,25-dihydroxyvitamin D.	Vitamin D	24-33	vitamin D receptor	Homo sapiens	44-47
24938764-7	2014	Evaluation at an early time point (1 week postinfection) showed that animals fed high vitamin D had decreased MAPK (p-P38 and p-JNK) activation in lamina propria leukocytes as well as decreased NFkappaB activation in colonic epithelial cells.	Vitamin D	86-95	mitogen-activated protein kinase 8	Mus musculus	128-131
24920642-2	2014	We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	101-119
24920642-2	2014	We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	121-124
24920642-8	2014	CONCLUSIONS: A higher predicted vitamin D score was significantly associated with a lower colorectal cancer risk, regardless of VDR status and other molecular features examined.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	128-131
25065871-1	2014	Vitamin D acts through vitamin D receptor, expressed in a variety of human tissues, including cancer tissues of various origins.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	23-41
24854954-1	2014	Vitamin D(3) belongs to the few nutritional compounds that has, via the binding of its metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) to the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	176-194
24854954-1	2014	Vitamin D(3) belongs to the few nutritional compounds that has, via the binding of its metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) to the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	196-199
24429404-0	2014	The impact of vitamin D status on the relative increase in fibroblast growth factor 23 and parathyroid hormone in chronic kidney disease.	Vitamin D	14-23	fibroblast growth factor 23	Homo sapiens	59-86
24429404-3	2014	As vitamin D insufficiency is associated with elevated PTH, we determined the effect of vitamin D status on FGF23 and PTH levels in relation to glomerular filtration rate (GFR) in people with CKD stage 3.	Vitamin D	88-97	fibroblast growth factor 23	Homo sapiens	108-113
24429404-7	2014	However, when 752 people with vitamin D insufficiency or deficiency were excluded, FGF23 was elevated in a greater proportion than PTH at all levels of eGFR.	Vitamin D	30-39	fibroblast growth factor 23	Homo sapiens	83-88
24429404-10	2014	Future studies of FGF23 in people with CKD should routinely determine their vitamin D status.	Vitamin D	76-85	fibroblast growth factor 23	Homo sapiens	18-23
24750549-3	2014	FGF23 has emerged as a major alpha-klotho-dependent endocrine regulator of mineral metabolism, functioning to activate vitamin D and as a phosphatonin.	Vitamin D	119-128	fibroblast growth factor 23	Homo sapiens	0-5
24894441-0	2014	Significance of vitamin d receptor gene polymorphisms for risk of hepatocellular carcinoma in chronic hepatitis C. BACKGROUND/AIMS: Biological and epidemiological data suggest that vitamin D levels may influence cancer development.	Vitamin D	181-190	vitamin D receptor	Homo sapiens	16-34
24899504-7	2014	PPARgamma agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARgamma signaling in regulating both vitamin D functions.	Vitamin D	158-167	vitamin D receptor	Homo sapiens	80-83
24899504-7	2014	PPARgamma agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARgamma signaling in regulating both vitamin D functions.	Vitamin D	158-167	vitamin D receptor	Homo sapiens	111-114
24917549-1	2014	Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	113-131
24917549-1	2014	Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
24887145-10	2014	Effects of VDR or VEGF blockade were partially prevented by vitamin D.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	11-14
24745702-2	2014	Vitamin D-binding protein transports vitamin D metabolites in the circulation.	Vitamin D	37-46	GC vitamin D binding protein	Homo sapiens	0-25
24797667-1	2014	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules.	Vitamin D	106-115	fibroblast growth factor 23	Mus musculus	0-27
24797667-1	2014	Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules.	Vitamin D	106-115	fibroblast growth factor 23	Mus musculus	29-34
24654573-3	2014	The retiferol, disubstituted at C-13, was bound to the ligand-binding domain (LBD) of vitamin D receptor (VDR) just like the vitamin D hormone [1,25-(OH)2D3].	Vitamin D	86-95	homeobox C13	Homo sapiens	32-36
24654573-3	2014	The retiferol, disubstituted at C-13, was bound to the ligand-binding domain (LBD) of vitamin D receptor (VDR) just like the vitamin D hormone [1,25-(OH)2D3].	Vitamin D	86-95	vitamin D receptor	Homo sapiens	106-109
24654573-7	2014	EXPERT OPINION: Docking experiments and molecular modeling have shown that positioning of vitamin D analog at the LBD of VDR is not disturbed by deletion of a large portion of the vitamin D, exactly as hypothesized.	Vitamin D	90-99	vitamin D receptor	Homo sapiens	121-124
24665943-11	2014	Some vitamin D however remains in the skin and is activated to interact with its vitamin D receptor to control cell proliferation using a variety of strategies including interacting with long non-coding RNAs to reduce risk of photocarcinogenesis.	Vitamin D	5-14	vitamin D receptor	Homo sapiens	81-99
24680778-0	2014	Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency.	Vitamin D	101-110	vitamin D receptor	Homo sapiens	15-18
24680778-2	2014	This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and genetic susceptibility to components of the metabolic syndrome, type 2 diabetes mellitus (T2DM), and vitamin D deficiency in the Saudi Arabian population.	Vitamin D	59-68	vitamin D receptor	Homo sapiens	79-82
24638155-2	2014	The aim of the current study was to investigate the association of VDR gene polymorphisms with melanoma risk, clinicopathological characteristics, and vitamin D levels.	Vitamin D	151-160	vitamin D receptor	Homo sapiens	67-70
24492489-1	2014	BACKGROUND: Vitamin D-deactivating enzyme CYP24A1 had controversial effects on prostate cancer risk; the genetic study also showed the controversial results.	Vitamin D	12-21	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	42-49
24860512-4	2014	Recent molecular studies have identified an extensive synergistic crosstalk between the vitamin D- and androgen-mediated mRNA and miRNA expression, adding an additional layer of post-transcriptional regulation to the known VDR- and AR-regulated gene activation.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	223-226
24810167-1	2014	Alterations in vitamin D homeostasis, mainly involving its nuclear receptor (VDR), could have a role in the pathophysiology of the spine.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	77-80
24792400-0	2014	Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	27-45
24154811-4	2014	Accumulating evidence now suggests that in addition to maintaining skeletal integrity, vitamin D also plays an integral role in regulating the general immune response, a function employed via its genomic actions on the vitamin D receptor (VDR).	Vitamin D	87-96	vitamin D receptor	Homo sapiens	219-237
24154811-4	2014	Accumulating evidence now suggests that in addition to maintaining skeletal integrity, vitamin D also plays an integral role in regulating the general immune response, a function employed via its genomic actions on the vitamin D receptor (VDR).	Vitamin D	87-96	vitamin D receptor	Homo sapiens	239-242
24154811-5	2014	The VDR is expressed in all immune cells and both directly and indirectly targeted by the bioactive form of vitamin D, 1,25-Dihydroxyvitamin D (1,25[OH]2D).	Vitamin D	108-117	vitamin D receptor	Homo sapiens	4-7
24727903-9	2014	Individuals with vitamin D deficiency had significantly higher levels of serum GM-CSF (p = 0.04), decreased circulating activated CD4+ (p = 0.04) and CD8+ T (p = 0.04) cell frequencies than individuals with sufficient vitamin D levels.	Vitamin D	17-26	CD8a molecule	Homo sapiens	150-153
24025724-0	2014	Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats.	Vitamin D	0-9	Kelch-like ECH-associated protein 1	Rattus norvegicus	29-34
24508736-3	2014	We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	55-58
24857306-0	2014	[The correlation of vitamin D level and vitamin D-binding protein gene polymorphism in chronic obstructive pulmonary disease].	Vitamin D	20-29	GC vitamin D binding protein	Homo sapiens	40-65
24844966-7	2014	Renin and angiotensin II in periventricular nucleus of VDR knockout mice were higher than those of wild type and was reduced by injecting vitamin D analogs into wild type.	Vitamin D	138-147	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	55-58
24844966-10	2014	The expression of c-fos in periventricular nucleus in VDR knockout mice was higher and it could be inhibited after an injection of vitamin D analog.	Vitamin D	131-140	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	54-57
24412515-5	2014	Our data also suggest that high vitamin D levels are only partially responsible for these hematopoietic changes in Klotho(-/-) mice.	Vitamin D	32-41	klotho	Mus musculus	115-121
24419359-2	2014	The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	128-146
24419359-2	2014	The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	148-151
24419359-2	2014	The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	128-146
24419359-2	2014	The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	148-151
24419359-5	2014	Expression of VDR and enzymes that metabolize vitamin D in fetal testis indicates a yet unknown role during development, which may be extrapolated from invasive testicular germ cell tumours where 1alpha,25-dihydroxyvitamin D induces a mesodermal differentiation of the pluripotent testicular cancer cells.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	14-17
24370753-2	2014	Vitamin D compounds are known to suppress T-cell activation by binding to vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	74-92
24370753-2	2014	Vitamin D compounds are known to suppress T-cell activation by binding to vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	94-97
24370753-2	2014	Vitamin D compounds are known to suppress T-cell activation by binding to vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	110-113
24370753-3	2014	The aim of this study was to investigate the association between vitamin D status and VDR gene polymorphisms and T1DM.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	86-89
24586832-3	2014	We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1.	Vitamin D	264-273	vitamin D receptor	Homo sapiens	88-91
24586832-3	2014	We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1.	Vitamin D	264-273	retinoid X receptor alpha	Homo sapiens	128-147
24586832-3	2014	We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1.	Vitamin D	264-273	retinoid X receptor alpha	Homo sapiens	149-157
24586832-5	2014	In support of their function as novel modulators of the vitamin D hormonal pathway we demonstrate that both SENP1 and SENP2 can interact with VDR and reverse its modification with SUMO2.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	142-145
24586832-5	2014	In support of their function as novel modulators of the vitamin D hormonal pathway we demonstrate that both SENP1 and SENP2 can interact with VDR and reverse its modification with SUMO2.	Vitamin D	56-65	small ubiquitin like modifier 2	Homo sapiens	180-185
24586832-7	2014	In combination, our results support a repressor function for SUMOylation of VDR and reveal SENPs as a novel class of VDR/RXR co-regulatory protein that significantly modulate the vitamin D response and which could also have important impact upon the functionality of both RXR-containing homo and heterodimers.	Vitamin D	179-188	vitamin D receptor	Homo sapiens	76-79
24586832-7	2014	In combination, our results support a repressor function for SUMOylation of VDR and reveal SENPs as a novel class of VDR/RXR co-regulatory protein that significantly modulate the vitamin D response and which could also have important impact upon the functionality of both RXR-containing homo and heterodimers.	Vitamin D	179-188	vitamin D receptor	Homo sapiens	117-120
24586832-7	2014	In combination, our results support a repressor function for SUMOylation of VDR and reveal SENPs as a novel class of VDR/RXR co-regulatory protein that significantly modulate the vitamin D response and which could also have important impact upon the functionality of both RXR-containing homo and heterodimers.	Vitamin D	179-188	retinoid X receptor alpha	Homo sapiens	121-124
24586832-7	2014	In combination, our results support a repressor function for SUMOylation of VDR and reveal SENPs as a novel class of VDR/RXR co-regulatory protein that significantly modulate the vitamin D response and which could also have important impact upon the functionality of both RXR-containing homo and heterodimers.	Vitamin D	179-188	retinoid X receptor alpha	Homo sapiens	272-275
24605214-10	2014	Especially, excess actions of FGF23 cause several hypophosphatemic rickets/osteomalacia with relatively low level of 1,25(OH)2D that had been classified as vitamin D-resistant rickets/osteomalacia.	Vitamin D	156-165	fibroblast growth factor 23	Homo sapiens	30-35
24605216-4	2014	In case of sufficient calcium supply, vitamin D and its metabolites can improve the calcium balance and facilitate mineral deposition in bone matrix largely without direct effects on bone cells, although some beneficial effects may occur via mature osteoblasts, as demonstrated in mice with osteoblast-specific overexpression of VDR or 1alpha-hydroxylase.	Vitamin D	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	329-332
24122604-1	2014	Since the discovery that the enzyme catalyzing the synthesis of the most active natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor (VDR)were expressed in a wide range of tissues and organs, not only involved in the mineral metabolism (MM), there has been increasing interest on the putative "non classical" roles of vitamin D metabolites, particularly on their possible effects on the cardiovascular (CV) system.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	158-161
24122604-1	2014	Since the discovery that the enzyme catalyzing the synthesis of the most active natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor (VDR)were expressed in a wide range of tissues and organs, not only involved in the mineral metabolism (MM), there has been increasing interest on the putative "non classical" roles of vitamin D metabolites, particularly on their possible effects on the cardiovascular (CV) system.	Vitamin D	129-138	vitamin D receptor	Homo sapiens	158-161
24184224-1	2014	PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population.	Vitamin D	73-82	7-dehydrocholesterol reductase	Homo sapiens	97-102
24184224-1	2014	PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population.	Vitamin D	73-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	125-132
24020384-9	2014	In particular, we highlight the emerging roles of aryl hydrocarbon (AHR), vitamin D (VDR), glucocorticoid (GR) and pregnane X (PXR) receptors in that regulation.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	85-88
24280059-6	2014	As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells.	Vitamin D	117-126	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	23-26
24280059-6	2014	As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells.	Vitamin D	117-126	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	134-188
24280059-6	2014	As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells.	Vitamin D	117-126	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	190-197
24280059-6	2014	As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells.	Vitamin D	248-257	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	134-188
24280059-6	2014	As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells.	Vitamin D	248-257	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	190-197
24053724-2	2014	The goal of this study was evaluate bone metabolism alterations after gastroplasty through the concentrations of carboxy-terminal cross-linking telopeptides of type-I collagen (CTX) and bone-specific alkaline phosphatase (BSAP) and vitamin D status.	Vitamin D	232-241	paired box 5	Homo sapiens	222-226
24127289-2	2014	These effects are mediated by the active form of vitamin D, 1,25(OH)2D3, which binds to a cytoplasmic protein called vitamin D receptor (VDR).	Vitamin D	49-58	vitamin D receptor	Homo sapiens	117-135
24127289-2	2014	These effects are mediated by the active form of vitamin D, 1,25(OH)2D3, which binds to a cytoplasmic protein called vitamin D receptor (VDR).	Vitamin D	49-58	vitamin D receptor	Homo sapiens	137-140
24247221-3	2014	Mice with disrupted vitamin D action--owing to gene deletion of the nuclear receptor vitamin D receptor (Vdr) or the gene encoding 1alpha-hydroxylase (Cyp27b1)--lose fat mass over time owing to an increase in energy expenditure, whereas mice with increased Vdr-mediated signalling in adipose tissue become obese.	Vitamin D	20-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	105-108
24247221-3	2014	Mice with disrupted vitamin D action--owing to gene deletion of the nuclear receptor vitamin D receptor (Vdr) or the gene encoding 1alpha-hydroxylase (Cyp27b1)--lose fat mass over time owing to an increase in energy expenditure, whereas mice with increased Vdr-mediated signalling in adipose tissue become obese.	Vitamin D	20-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	257-260
24475177-6	2014	Vitamin D supplementation had no significant effects on RV replication, but potentiated secretion of CXCL8 and CXCL10 from infected or uninfected cells.	Vitamin D	0-9	C-X-C motif chemokine ligand 10	Homo sapiens	111-117
24436433-3	2014	The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D, binds to the vitamin D receptor that regulates numerous genes involved in fundamental processes of potential relevance to cardiovascular disease, including cell proliferation and differentiation, apoptosis, oxidative stress, membrane transport, matrix homeostasis, and cell adhesion.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	79-97
25227596-1	2014	BACKGROUND: Among the potentially critical nutrients for toddlers, vitamin D, iron and long-chain polyunsaturated fatty acids (LC-PUFA) have recently gained special attention.	Vitamin D	67-76	pumilio RNA binding family member 3	Homo sapiens	130-134
23869781-4	2014	Based on these findings, CYP24A1-specific inhibitors and vitamin D analogs which are resistant to CYP24A1-dependent catabolism might be useful for cancer treatment.	Vitamin D	57-66	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	98-105
23869781-9	2014	Based on these results, we conclude that (1) high affinity for VDR, (2) resistance to CYP24A1-dependent catabolism, (3) low affinity for DBP, and (4) low calcemic effect may be required for designing potent vitamin D analogs for cancer treatment.	Vitamin D	207-216	vitamin D receptor	Homo sapiens	63-66
23869781-9	2014	Based on these results, we conclude that (1) high affinity for VDR, (2) resistance to CYP24A1-dependent catabolism, (3) low affinity for DBP, and (4) low calcemic effect may be required for designing potent vitamin D analogs for cancer treatment.	Vitamin D	207-216	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	86-93
24948018-5	2014	It also uncovered the molecular aspects of vitamin D action, from its nuclear receptor, VDR, to the various target genes of this hormone.	Vitamin D	43-52	vitamin D receptor	Homo sapiens	88-91
24597598-4	2014	VDR activators (calcitriol and paricalcitol) are available for the treatment of vitamin D deficiency, which can result from inadequate cutaneous production and/or low dietary intake.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	0-3
24597598-8	2014	In mice lacking VDR or CYP27B1 (1alpha-hydroxylase - an enzyme, which converts vitamin D to its active form), in addition to the expected phenotype (hypocalcaemia, secondary hyperparathyroidism and osteomalacia), development of hypertension and cardiac hypertrophy were also observed.	Vitamin D	79-88	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	16-19
24200978-1	2014	Previous studies have identified several common genetic variants in VDR, GC and CYP2R1 to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D deficiency in Western populations.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	68-71
24577200-0	2014	Serum fibroblast growth factor 23 is a useful marker to distinguish vitamin D-deficient rickets from hypophosphatemic rickets.	Vitamin D	68-77	fibroblast growth factor 23	Homo sapiens	6-33
24577200-2	2014	Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	72-99
24577200-2	2014	Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	101-106
25060608-1	2014	BACKGROUND/AIMS: We analyzed the vitamin D receptor (VDR) gene in 2 Greek patients who exhibited the classical features of hereditary vitamin D-resistant rickets (HVDRR) type II, including severe bone deformities and alopecia.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
25969372-0	2014	Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort.	Vitamin D	62-71	vitamin D receptor	Homo sapiens	0-18
25969372-7	2014	RESULTS: let-7b expression negatively correlated with vitamin D intake (rs=-0.20, p=0.005).	Vitamin D	54-63	microRNA let-7b	Homo sapiens	9-15
25969372-12	2014	CONCLUSIONS: The correlation between vitamin D intake and let-7a/b expression in this cohort varies with VDR genotype.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	105-108
24105653-6	2014	Vitamin D restrained the expression of both NFkappaB- and STAT1-induced antiviral genes.	Vitamin D	0-9	signal transducer and activator of transcription 1	Homo sapiens	58-63
24105653-7	2014	However, while NFkappaB control by vitamin D remained intact, both RSV-induced phosphorylation of STAT1 and expression of its downstream targets, IRF1 and IRF7, escaped vitamin D control in FokI epithelial cells.	Vitamin D	169-178	signal transducer and activator of transcription 1	Homo sapiens	98-103
24105653-9	2014	Hence, we provide mechanistic insight that the FokI VDR polymorphism renders STAT1-mediated antiviral immune reactions to RSV infection non-responsive to vitamin D control, resulting in enhanced immunopathology and exacerbated RSV bronchiolitis.	Vitamin D	154-163	vitamin D receptor	Homo sapiens	52-55
24140714-1	2013	Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone.	Vitamin D	111-120	fibroblast growth factor 23	Mus musculus	44-71
24140714-1	2013	Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone.	Vitamin D	111-120	fibroblast growth factor 23	Mus musculus	73-79
24245571-3	2013	Concerning the synthesis of vitamin D, the hydroxylases CYP2R1, CYP27B1 and CYP24A1 play a critical role, and the latter molecule determines the biological half-life of 1,25(OH)2 D3 , which is synthesized in the proximal renal tubules.	Vitamin D	28-37	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	76-83
24245571-9	2013	CONCLUSION: We thus conclude that upregulated gene expression of the catabolizing CYP24A1 as well as the synthesizing CYP2R1 and CYP27B1 may lead to a misbalance of vitamin D metabolites in ccRCC and thus contributing to its pathogenesis.	Vitamin D	165-174	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	82-89
24067280-3	2013	Current research has been focused on identification of new variants of genes involved in vitamin D pathway, namely in vitamin D receptor and enzymes of vitamin D metabolism.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	118-136
24108316-11	2013	Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	110-113
24217116-3	2013	Conversely, those with K-ras mutations are VDRlow and vitamin D-refractory.	Vitamin D	54-63	KRAS proto-oncogene, GTPase	Homo sapiens	23-28
23340856-5	2013	FGF23 is an endocrine fibroblast growth factor acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D with key effects on the bone/kidney/parathyroid axis, and has been shown to increase in patients with ADPKD, even with normal renal function.	Vitamin D	121-130	fibroblast growth factor 23	Homo sapiens	0-5
24251203-7	2013	The results indicate a potential antidiabetic function of vitamin D on GLUT1, GLUT4, VDR, and IR by improving receptor gene expression suggesting a role for vitamin D in regulation of expression of the glucose transporters in muscle cells.	Vitamin D	58-67	solute carrier family 2 member 1	Homo sapiens	71-76
24073854-3	2013	Our study aimed to identify the relationship between three vitamin D-related genes (group specific component [GC], cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1), and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and rickets in Han Chinese children from northeastern China.	Vitamin D	59-68	7-dehydrocholesterol reductase	Homo sapiens	262-267
24073854-3	2013	Our study aimed to identify the relationship between three vitamin D-related genes (group specific component [GC], cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1), and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and rickets in Han Chinese children from northeastern China.	Vitamin D	59-68	NAD synthetase 1	Homo sapiens	268-275
24084050-8	2013	Two variants: rs731236[A] (VDR) and rs732594[A] (SCUBE3) showed a significant association with serum Vit D levels in CD patients.	Vitamin D	101-106	vitamin D receptor	Homo sapiens	27-30
23625971-4	2013	FGF23 is a hormone produced by osteoblasts/osteocytes in bone that acts on the kidney to regulate phosphate and vitamin D metabolism through activation of FGF receptor/alpha-Klotho co-receptor complexes.	Vitamin D	112-121	fibroblast growth factor 23	Homo sapiens	0-5
24119849-3	2013	Mounting evidence from animal and clinical studies has shown beneficial effects of vitamin D therapy on the renal and cardiovascular systems, and the underlying renoprotective and cardioprotective mechanisms of vitamin D receptor (VDR)-mediated signaling are under intense investigation.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	231-234
24015259-1	2013	OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	11-38
24015259-1	2013	OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease.	Vitamin D	91-100	fibroblast growth factor 23	Homo sapiens	40-45
23973989-0	2013	Variation of vitamin D in cow"s milk and interaction with beta-lactoglobulin.	Vitamin D	13-22	beta-lactoglobulin	Bos taurus	58-76
23973989-6	2013	A relationship was highlighted between vitamin D and the genetic polymorphism of beta-lactoglobulin, the main bovine whey protein which is involved in the transport of small hydrophobic molecules such as retinol and vitamin D.	Vitamin D	39-48	beta-lactoglobulin	Bos taurus	81-99
23973989-6	2013	A relationship was highlighted between vitamin D and the genetic polymorphism of beta-lactoglobulin, the main bovine whey protein which is involved in the transport of small hydrophobic molecules such as retinol and vitamin D.	Vitamin D	216-225	beta-lactoglobulin	Bos taurus	81-99
23505057-1	2013	Fibroblast growth factor 23 (FGF23) is an osteocyte-derived hormone that regulates phosphate and vitamin D homeostasis.	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	0-27
23505057-1	2013	Fibroblast growth factor 23 (FGF23) is an osteocyte-derived hormone that regulates phosphate and vitamin D homeostasis.	Vitamin D	97-106	fibroblast growth factor 23	Homo sapiens	29-34
23621113-5	2013	METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR.	Vitamin D	26-35	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	198-201
23621113-7	2013	In HFD mice, vitamin D decreased VDR expression to 0.5-fold in muscle (P=0.002), and increased it to 3.6-fold in the liver (P&lt;0.001); however, VDR transcription was unaltered in adipose tissue.	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	33-36
23621113-7	2013	In HFD mice, vitamin D decreased VDR expression to 0.5-fold in muscle (P=0.002), and increased it to 3.6-fold in the liver (P&lt;0.001); however, VDR transcription was unaltered in adipose tissue.	Vitamin D	13-22	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	146-149
23849224-15	2013	Our results also suggest that VDR binding in response to physiological levels of vitamin D occurs predominantly in a VDR motif-independent manner.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	30-33
23849224-15	2013	Our results also suggest that VDR binding in response to physiological levels of vitamin D occurs predominantly in a VDR motif-independent manner.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	117-120
23596175-13	2013	Feeding klothohm mice a vitamin D-deficient diet decreased NCKX activity, augmented LPS-induced increase of [Ca2+]i, and enhanced migration of klothohm DCs, thus dissipating the differences between klothohm DCs and klotho+/+ DCs.	Vitamin D	24-33	klotho	Mus musculus	8-14
23677864-2	2013	We previously demonstrated that type 2 diabetic rats exhibit vitamin D deficiency due to aberrant megalin-mediated endocytosis and excessive urinary excretion of 25-hydroxycholecalciferol (25D3) and vitamin D-binding protein (DBP).	Vitamin D	61-70	LDL receptor related protein 2	Rattus norvegicus	98-105
23677864-2	2013	We previously demonstrated that type 2 diabetic rats exhibit vitamin D deficiency due to aberrant megalin-mediated endocytosis and excessive urinary excretion of 25-hydroxycholecalciferol (25D3) and vitamin D-binding protein (DBP).	Vitamin D	61-70	D-box binding PAR bZIP transcription factor	Rattus norvegicus	226-229
23220545-1	2013	The identification of the vitamin D receptor (VDR) in skeletal muscle tissue and research in muscle strength and development in VDR-null mice confirms a role for vitamin D in muscle function.	Vitamin D	26-35	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	46-49
23246987-1	2013	Recently, we evaluated a novel skeleton in the vitamin D family, 14-epi-1alpha,25(OH)2-19-nortachysterol, and discovered its unique binding configuration in the human vitamin D receptor (VDR) with the C5,6- and C7,8-s-trans triene configuration.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	167-185
23246987-1	2013	Recently, we evaluated a novel skeleton in the vitamin D family, 14-epi-1alpha,25(OH)2-19-nortachysterol, and discovered its unique binding configuration in the human vitamin D receptor (VDR) with the C5,6- and C7,8-s-trans triene configuration.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	187-190
22981997-5	2013	We and others have also shown that increased vitamin D activity in mature osteoblasts by increasing levels of VDR or CYP27B1 leads to improved bone mineral volume using two separate transgenic mouse models.	Vitamin D	45-54	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	110-113
23142286-2	2013	The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2 D3) is a natural ligand for vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	99-117
23142286-2	2013	The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2 D3) is a natural ligand for vitamin D receptor (VDR).	Vitamin D	19-28	vitamin D receptor	Homo sapiens	119-122
23142286-5	2013	The mechanism of vitamin D action is mediated by the nuclear VDR and the signaling cascade for its action is extensively reported.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	61-64
23142286-7	2013	These include (1) differential effects of vitamin D in maintaining cell proliferation when the cells are under stress but suppressing cell growth when the cells are transformed; (2) functional significance of VDR polymorphism in potential vitamin D responsiveness; (3) regulation of constitutive splicing of vitamin D target gene, CYP24a, by the hormone and its significance; and (4) regulation of microRNA by vitamin D in breast cancer.	Vitamin D	239-248	vitamin D receptor	Homo sapiens	209-212
23142286-7	2013	These include (1) differential effects of vitamin D in maintaining cell proliferation when the cells are under stress but suppressing cell growth when the cells are transformed; (2) functional significance of VDR polymorphism in potential vitamin D responsiveness; (3) regulation of constitutive splicing of vitamin D target gene, CYP24a, by the hormone and its significance; and (4) regulation of microRNA by vitamin D in breast cancer.	Vitamin D	239-248	vitamin D receptor	Homo sapiens	209-212
23142286-7	2013	These include (1) differential effects of vitamin D in maintaining cell proliferation when the cells are under stress but suppressing cell growth when the cells are transformed; (2) functional significance of VDR polymorphism in potential vitamin D responsiveness; (3) regulation of constitutive splicing of vitamin D target gene, CYP24a, by the hormone and its significance; and (4) regulation of microRNA by vitamin D in breast cancer.	Vitamin D	239-248	vitamin D receptor	Homo sapiens	209-212
23800151-13	2013	After treated with activated vitamin D, the level of Th1 cytokines decreased while the Th2 cytokine level increased in the sera (p &lt; 0.05).	Vitamin D	29-38	negative elongation factor complex member C/D	Homo sapiens	53-56
23453529-1	2013	BACKGROUND: Vitamin D regulates many biological processes including bone metabolism, innate immune response, and cell proliferation and differentiation by binding to its receptor VDR.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	179-182
23532406-3	2013	FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells.	Vitamin D	44-53	fibroblast growth factor 23	Homo sapiens	0-5
23858619-0	2013	Vitamin D action: lessons from VDR and Cyp27b1 null mice.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	31-34
23858619-2	2013	Inactivation of the vitamin D receptor (VDR) or the enzymes metabolizing its ligand (especially Cyp27bl) in mice has clearly demonstrated that the active form of vitamin D [1,25(OH)2D] is essential to stimulate calcium absorption in the gut during normal/low calcium intake, and as a consequence, that 1,25(OH)2D is required to maintain normal serum calcium, bone and growth plate homeostasis.	Vitamin D	20-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	40-43
23690102-3	2013	Vitamin D exerts its effect through vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	36-54
23690102-3	2013	Vitamin D exerts its effect through vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	56-59
25392765-0	2013	Increased vitamin D is associated with decline of naive, but accumulation of effector, CD8 T cells during early aging.	Vitamin D	10-19	CD8a molecule	Homo sapiens	87-90
25392765-4	2013	This study determined the relationship between vitamin D levels and CD8 T-cell status in 34 healthy female subjects (all &gt;60 years old).	Vitamin D	47-56	CD8a molecule	Homo sapiens	68-71
25392765-9	2013	The results show that higher levels of vitamin D are correlated with decreased frequencies of naive CD8 T cells during early aging, suggesting that higher levels of 25(OH)D accelerate CD8 T-cell senescence.	Vitamin D	39-48	CD8a molecule	Homo sapiens	100-103
25392765-9	2013	The results show that higher levels of vitamin D are correlated with decreased frequencies of naive CD8 T cells during early aging, suggesting that higher levels of 25(OH)D accelerate CD8 T-cell senescence.	Vitamin D	39-48	CD8a molecule	Homo sapiens	184-187
23682710-2	2013	The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	96-114
23682710-2	2013	The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	116-119
23569273-6	2013	Concordantly, the mobility of circulating CX3CR1(+) osteoclast precursor monocytes was significantly increased on systemic administration of active vitamin D.	Vitamin D	148-157	chemokine (C-X3-C motif) receptor 1	Mus musculus	42-48
23585857-6	2013	RESULTS: Almost half (47%) of the S-25-OHD values were consistent with subnormal vitamin D status (S-25-OHD &lt;50 nmol/L) while only 12% were &gt;80 nmol/L.	Vitamin D	81-90	ribosomal protein S25	Homo sapiens	34-42
23585857-8	2013	Mean S-25-OHD concentration differed between age groups (Kruskal-Wallis; p&lt;0.001), adolescents being at highest risk for vitamin D insufficiency.	Vitamin D	124-133	ribosomal protein S25	Homo sapiens	5-13
23358686-2	2013	24-Hydroxylase, encoded by the CYP24A1 gene, is the key enzyme for degrading many forms of vitamin D including the most active form, 1,25D(3).	Vitamin D	91-100	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	31-38
24175086-2	2013	Recently loss-of-function mutations in the CYP24A1 gene, which encodes the vitamin D-metabolizing enzyme 24-hydroxylase, have been found in these patients.	Vitamin D	75-84	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	43-50
23154302-0	2013	Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection.	Vitamin D	44-53	brain-derived neurotrophic factor	Rattus norvegicus	129-133
23300018-1	2013	Several studies have suggested that the anticancerogenous effects of vitamin D might be modulated by genetic variants in the vitamin D receptor (VDR) gene.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	125-143
23300018-1	2013	Several studies have suggested that the anticancerogenous effects of vitamin D might be modulated by genetic variants in the vitamin D receptor (VDR) gene.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	145-148
23180655-7	2013	Our results suggest that SNPs in the RXRA and PLAUR genes in the vitamin D pathway may contribute to breast cancer DFS.	Vitamin D	65-74	retinoid X receptor alpha	Homo sapiens	37-41
23620712-6	2013	Proposed mechanisms for vitamin D deficiency in diabetes include: 1) genetic predisposition (T1D); 2) increased BMI (T2D); 3) concurrent albuminuria (T1D or T2D); or 4) exaggerated renal excretion of vitamin D metabolites or vitamin D binding protein (T1D, T2D, animal models).	Vitamin D	24-33	GC vitamin D binding protein	Homo sapiens	225-250
23277283-2	2013	The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	46-64
23277283-2	2013	The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	66-69
23277283-2	2013	The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	91-94
23020803-5	2013	Since then, the findings that vitamin D receptors (VDR) are present in many body tissues and that vitamin D metabolizing enzymes can be found in various cells outside the kidney, including the intestine, prostate, immune cells, and within the skin itself (reviewed in reference 3), have revolutionized the vitamin D business.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	51-54
23032084-2	2013	The biologic activity of vitamin D and its analogs is mediated by vitamin D receptor (VDR), which is distributed widely throughout the body.	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	66-84
23032084-2	2013	The biologic activity of vitamin D and its analogs is mediated by vitamin D receptor (VDR), which is distributed widely throughout the body.	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	86-89
23465500-2	2013	FGF23 is important in the regulation of phosphate and vitamin D metabolism, whereas Ocn participates in endocrine networks, coordinating bone and fat mass, energy metabolism, and sex hormone production.	Vitamin D	54-63	fibroblast growth factor 23	Homo sapiens	0-5
23465502-2	2013	Renal vitamin D metabolism requires filtration and tubular reabsorption of 25-hydroxyvitamin D and is regulated by parathyroid hormone, fibroblast growth factor-23, and 1,25-dihydroxyvitamin D.	Vitamin D	6-15	fibroblast growth factor 23	Homo sapiens	136-163
23465502-4	2013	In addition, pharmacokinetic studies and epidemiologic studies of 24,25-dihydroxyvitamin D, the most abundant product of 25-hydroxyvitamin D catabolism by CYP24A1, suggest that vitamin D catabolism also is reduced.	Vitamin D	81-90	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	155-162
22959760-1	2013	Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23).	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	187-214
22959760-1	2013	Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23).	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	216-222
22959760-1	2013	Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23).	Vitamin D	133-142	fibroblast growth factor 23	Homo sapiens	187-214
22959760-1	2013	Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23).	Vitamin D	133-142	fibroblast growth factor 23	Homo sapiens	216-222
23114382-6	2013	Recent advances in the methodology of large-scale genetic association studies, including coordinated international collaboration, have identified associations of CG, DHCR1, CYP2R1, VDR, and CYP24A1 with serum levels of vitamin D.	Vitamin D	219-228	vitamin D receptor	Homo sapiens	181-184
23114382-6	2013	Recent advances in the methodology of large-scale genetic association studies, including coordinated international collaboration, have identified associations of CG, DHCR1, CYP2R1, VDR, and CYP24A1 with serum levels of vitamin D.	Vitamin D	219-228	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	190-197
23200756-2	2013	Polymorphisms in the VDR gene may alter the actions of vitamin D and then influence the development and the severity of asthma.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	21-24
23200756-3	2013	AIMS: We aimed at elucidating the genetic association of VDR gene polymorphisms with susceptibility to asthma in Tunisian children and with serum vitamin D levels.	Vitamin D	146-155	vitamin D receptor	Homo sapiens	57-60
23070913-1	2013	Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	77-95
23070913-1	2013	Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	97-100
23070913-1	2013	Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes.	Vitamin D	49-58	GC vitamin D binding protein	Homo sapiens	106-131
23070913-1	2013	Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes.	Vitamin D	49-58	GC vitamin D binding protein	Homo sapiens	133-137
23070913-1	2013	Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes.	Vitamin D	77-86	vitamin D receptor	Homo sapiens	97-100
23129826-8	2013	After adjustment for age, gender, serum 25-hydroxyvitamin D levels and concomitant medications (calcium, supplemental vitamin D and calcitriol), we estimated that the mean Klotho change was 3.2 pg/mL (95% CI 1.2-5.2 pg/mL, P = 0.0019) for each 1 mL/min/1.73 m(2) GFR change.	Vitamin D	50-59	klotho	Homo sapiens	172-178
23178257-6	2013	By comparing the actions of the VDR, a relatively well-understood and characterized protein, with those of other transcription factors, we aim to build a realistic positioning of vitamin D signaling in the context of other intracellular signaling systems.	Vitamin D	179-188	vitamin D receptor	Homo sapiens	32-35
23142789-5	2013	Calbindin refers to several Ca-binding proteins originally described as vitamin D-dependent Ca-binding factors in the intestine, and kidney of birds and mammals.	Vitamin D	72-81	calbindin 1	Mus musculus	0-9
23635517-8	2013	CONCLUSIONS: Baseline vitamin D status and serum phosphorous are independent determinants of the longitudinal variation in PTH and FGF23, respectively.	Vitamin D	22-31	fibroblast growth factor 23	Homo sapiens	131-136
24348674-2	2013	Considering that 1,25(OH)2D3 has been suggested as a potent inducer of RANKL expression, it should clarify whether vitamin D supplement could result in RANKL overexpression and thereby facilitate excessive osteoclastogenesis and bone resorption in RA.	Vitamin D	115-124	TNF superfamily member 11	Homo sapiens	71-76
24348674-2	2013	Considering that 1,25(OH)2D3 has been suggested as a potent inducer of RANKL expression, it should clarify whether vitamin D supplement could result in RANKL overexpression and thereby facilitate excessive osteoclastogenesis and bone resorption in RA.	Vitamin D	115-124	TNF superfamily member 11	Homo sapiens	152-157
23427793-1	2013	The vitamin D binding protein (DBP) is the major plasma carrier for vitamin D and its metabolites, but it is also an actin scavenger, and is the precursor to the immunomodulatory protein, Gc-MAF.	Vitamin D	4-13	GC vitamin D binding protein	Homo sapiens	188-194
23624519-0	2013	A new mechanism for amyloid-beta induction of iNOS: vitamin D-VDR pathway disruption.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	62-65
23624519-5	2013	Our silencing experiments suggest that vitamin D regulates iNOS via VDR, not 1,25-MARRS, in cortical neurons.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	68-71
23624519-7	2013	While our previous work demonstrates that Abeta pathology includes VDR suppression, our present work demonstrates that Abeta induces iNOS and that this effect is mediated via disruption of the vitamin D-VDR pathway.	Vitamin D	193-202	vitamin D receptor	Homo sapiens	203-206
22886720-9	2013	Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD).	Vitamin D	95-104	fibroblast growth factor 23	Homo sapiens	23-28
22960018-9	2013	The interaction between VDR and PTPN2 polymorphisms in the risk of progression to T1D offers insight concerning the role of vitamin D in the etiology of T1D.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	24-27
23085014-9	2013	Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health.	Vitamin D	167-176	fibroblast growth factor 23	Homo sapiens	239-266
23085014-9	2013	Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health.	Vitamin D	167-176	fibroblast growth factor 23	Homo sapiens	268-273
23085014-9	2013	Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health.	Vitamin D	167-176	klotho	Homo sapiens	283-289
23554871-1	2013	BACKGROUND: Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	78-96
23554871-1	2013	BACKGROUND: Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	98-101
22610818-7	2012	Herein we demonstrate that although the vitamin D receptor (VDR) is present in both IBC and non-IBC cell lines, the effect of vitamin D treatment is significant only on the IBC cells.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	60-63
23108197-5	2012	Iron deficiency may affect autosomal dominant hypophosphatemic rickets phenotype by regulating FGF23 production.Current treatment with activated vitamin D metabolites and oral inorganic phosphate salts may partially correct skeletal lesions and linear growth in patients with hypophosphatemic rickets.	Vitamin D	145-154	fibroblast growth factor 23	Homo sapiens	95-100
22457344-3	2012	After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells.	Vitamin D	18-27	interleukin 10	Homo sapiens	142-147
22160397-4	2012	RAAS activation can reduce renal Klotho expression, and the Klotho-fibroblast growth factor 23 interaction may further reduce the production of active vitamin D.	Vitamin D	151-160	klotho	Homo sapiens	60-66
22962257-3	2012	The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D(3) and regulates numerous physiological processes.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
22962257-10	2012	The pancreatic VDR-PYY pathway may mediate a regulatory function of vitamin D in the neuroendocrine system.	Vitamin D	68-77	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	15-18
22576297-8	2012	Homozygous carriers of the rare DHCR7 allele or the common CYP2R1 allele presented with reduced 25(OH)-vitamin D levels (P &lt; 0.05).	Vitamin D	103-112	7-dehydrocholesterol reductase	Homo sapiens	32-37
22917542-2	2012	Vitamin D exerts its effects through vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	37-55
22917542-2	2012	Vitamin D exerts its effects through vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	57-60
22739976-1	2012	Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites.	Vitamin D	117-126	fibroblast growth factor 23	Homo sapiens	26-55
22739976-1	2012	Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites.	Vitamin D	117-126	fibroblast growth factor 23	Homo sapiens	57-62
22739976-4	2012	The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism.	Vitamin D	132-141	fibroblast growth factor 23	Mus musculus	4-9
22739976-4	2012	The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism.	Vitamin D	132-141	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	32-39
22739976-4	2012	The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism.	Vitamin D	132-141	fibroblast growth factor 23	Mus musculus	118-123
23111742-5	2012	It is suggested that polymorphisms and haplotypes in the VDR gene may explain the differences in response to vitamin D therapy.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	57-60
23111742-7	2012	The Fok I, Bsm I, Apa I and Taq I polymorphisms were examined by PCR-RFLP, and 50 subjects received vitamin D therapy to evaluate the association between VDR gene polymorphisms and response to vitamin D therapy.	Vitamin D	193-202	vitamin D receptor	Homo sapiens	154-157
23236317-1	2012	BACKGROUND: Vitamin D can translocate a vitamin D receptor (VDR) from the nucleus to the cell membranes.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	40-58
23236317-1	2012	BACKGROUND: Vitamin D can translocate a vitamin D receptor (VDR) from the nucleus to the cell membranes.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	60-63
23236317-12	2012	CONCLUSION: CSE has an ability to inhibit vitamin D-induced VDR translocation, but MAPKs are not involved in this inhibition.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	60-63
23146737-0	2012	[Expression of RANTES in the lung tissue of asthmatic rats, and the intervention effect of vitamin D on RANTES expression].	Vitamin D	91-100	C-C motif chemokine ligand 5	Rattus norvegicus	104-110
23146737-1	2012	OBJECTIVE: To investigate the effect of vitamin D on the expression of chemokine regulated on activation, normal T cells expressed and secreted (RANTES) in the lung tissue of asthmatic rats, and the role of vitamin D in the control of asthmatic airway inflammation and the synergistic action of hormones.	Vitamin D	40-49	C-C motif chemokine ligand 5	Rattus norvegicus	145-151
23146737-9	2012	Protein expression of RANTES in the lung tissue and BALF was significantly higher in the asthma group than in the normal control group (P&lt;0.05), while it was lower in the intervention groups than in the asthma group, exhibiting significant differences between each intervention group and the asthma group (P&lt;0.05) (except the difference in protein expression of RANTES in BALF between the vitamin D intervention and asthma groups).	Vitamin D	395-404	C-C motif chemokine ligand 5	Rattus norvegicus	22-28
23146737-10	2012	The budesonide+vitamin D intervention group showed less protein expression of RANTES in the lung tissue and BALF than both the budesonide intervention and vitamin D intervention groups (P&lt;0.05).	Vitamin D	15-24	C-C motif chemokine ligand 5	Rattus norvegicus	78-84
23146737-12	2012	The budesonide+vitamin D intervention group showed the lowest level of RANTES mRNA, with no significant difference from the normal control group.	Vitamin D	15-24	C-C motif chemokine ligand 5	Rattus norvegicus	71-77
23146737-14	2012	Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES.	Vitamin D	0-9	C-C motif chemokine ligand 5	Rattus norvegicus	54-60
23146737-14	2012	Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES.	Vitamin D	0-9	C-C motif chemokine ligand 5	Rattus norvegicus	151-157
23146737-14	2012	Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES.	Vitamin D	78-87	C-C motif chemokine ligand 5	Rattus norvegicus	54-60
23146737-14	2012	Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES.	Vitamin D	78-87	C-C motif chemokine ligand 5	Rattus norvegicus	151-157
23146737-15	2012	Vitamin D can be used together with budesonide to further decrease the mRNA and protein expression of RANTES.	Vitamin D	0-9	C-C motif chemokine ligand 5	Rattus norvegicus	102-108
23095332-1	2012	BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor.	Vitamin D	127-136	vitamin D receptor	Homo sapiens	170-188
23098125-13	2012	No effects of vitamin D were seen on the IL-1beta and IL-10 expression in the young rats; (3) vitamin D increased Abeta clearance and decreased amyloid burden in the aged rats while no significant difference was seen between the young animal groups.	Vitamin D	94-103	amyloid beta precursor protein	Rattus norvegicus	114-119
22695798-6	2012	In addition, vitamin D (10(-10), 10(-8) and 10(-6) M) was added to sebocytes treated with vitamin D receptor (VDR) siRNA.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	90-108
22695798-6	2012	In addition, vitamin D (10(-10), 10(-8) and 10(-6) M) was added to sebocytes treated with vitamin D receptor (VDR) siRNA.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	110-113
22695798-10	2012	Gene expression of hCAP-18 by treatment with vitamin D was blocked in sebocytes treated with VDR siRNA.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	93-96
22695798-11	2012	In conclusion, treatment with vitamin D resulted in increased expression of LL-37 through the vitamin D receptor of cultured sebocytes.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	94-112
22457088-14	2012	CONCLUSION: Vitamin D deficiency in HD patients who had not taken vitamin D receptor agonist (VDRA) is associated with an increased risk of all-cause mortality.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	66-84
23023636-2	2012	FGF23 exerts its effects in kidney by decreasing both renal phosphate (Pi) reabsorption and vitamin D activation.	Vitamin D	92-101	fibroblast growth factor 23	Homo sapiens	0-5
23023636-4	2012	Circulating level of FGF23 appears to be regulated by systemic factors as well, including vitamin D and PTH.	Vitamin D	90-99	fibroblast growth factor 23	Homo sapiens	21-26
22899855-0	2012	MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.	Vitamin D	33-42	dual specificity phosphatase 1	Mus musculus	0-5
22750284-3	2012	The active metabolite of the vitamin D endocrine system, 1,25-dihydroxyvitamin D (calcitriol), exerts pleiotropic effects through its interaction with the vitamin D receptor.	Vitamin D	29-38	vitamin D receptor	Homo sapiens	155-173
22842395-1	2012	Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson"s disease (PD).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	155-173
22842395-1	2012	Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson"s disease (PD).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	175-178
22796435-9	2012	Together, these data provide evidence that interfering with RhoA-ROCK signaling in autoreactive Th1/Th17 cells can improve vitamin D(3) efficacy in clinical trials of MS and related neurodegenerative disorders.	Vitamin D	123-132	negative elongation factor complex member C/D	Homo sapiens	96-99
22677193-12	2012	Increased expression of VDR sensitized tumor cells to the inhibitory effects of vitamin D.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	24-27
22993666-1	2012	AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1).	Vitamin D	15-24	interleukin 17A	Homo sapiens	94-99
22993666-20	2012	IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected.	Vitamin D	142-151	interleukin 17A	Homo sapiens	156-169
22733815-1	2012	FGFs 19, 21, and 23 are hormones that regulate in a Klotho co-receptor-dependent fashion major metabolic processes such as glucose and lipid metabolism (FGF21) and phosphate and vitamin D homeostasis (FGF23).	Vitamin D	178-187	klotho	Homo sapiens	52-58
22733815-1	2012	FGFs 19, 21, and 23 are hormones that regulate in a Klotho co-receptor-dependent fashion major metabolic processes such as glucose and lipid metabolism (FGF21) and phosphate and vitamin D homeostasis (FGF23).	Vitamin D	178-187	fibroblast growth factor 23	Homo sapiens	201-206
22710747-6	2012	One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade.	Vitamin D	104-113	vitamin D receptor	Homo sapiens	122-125
22710747-6	2012	One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade.	Vitamin D	104-113	retinoid X receptor alpha	Homo sapiens	149-157
22710747-6	2012	One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade.	Vitamin D	104-113	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	159-166
22710747-6	2012	One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade.	Vitamin D	104-113	vitamin D receptor	Homo sapiens	171-174
22528806-1	2012	The serum vitamin D binding protein (DBP), also known as GC-globulin, is a multifunctional protein known for its role in the transport of vitamin D metabolites.	Vitamin D	10-19	GC vitamin D binding protein	Homo sapiens	57-68
22537547-14	2012	Vitamin D deficiency causes increase in the expression of TNF-alpha, thereby increasing inflammation and decreases the expression of VDR and prohibitin.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	133-136
22537547-15	2012	Supplementation with vitamin D might reduce the levels of TNF-alpha, thereby increasing the expression of VDR and prohibitin that could be responsible for reducing allergic airway inflammation.	Vitamin D	21-30	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	106-109
22703926-2	2012	BACKGROUND: FGF-23 increases renal phosphorus excretion and inhibits vitamin D activation.	Vitamin D	69-78	fibroblast growth factor 23	Homo sapiens	12-18
23951494-1	2012	FGF23 is a hormone that regulates phosphate and vitamin D metabolism by binding to Klotho-fibroblast growth factor (FGF) receptor complex.	Vitamin D	48-57	fibroblast growth factor 23	Homo sapiens	0-5
22179019-1	2012	CYP24A1 functions in vitamin D target tissues to degrade 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)).	Vitamin D	21-30	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	0-7
22544453-9	2012	CONCLUSION: These results suggest that germline genetic variation in VDR, and therefore the vitamin D pathway, may mediate an association between early life sun exposure and NHL risk.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	69-72
22511602-3	2012	Vitamin D receptor (VDR) and CYP27B1 and CYP24A1 (respectively activating and catabolizing vitamin D) expression was studied (RT-PCR, immunohistochemistry) in normal thyroid, follicular adenoma (FA), differentiated thyroid cancer (DTC) consisting of the papillary (PTC) and follicular (FTC) subtype, and anaplastic thyroid cancer (ATC).	Vitamin D	91-100	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	41-48
22541691-0	2012	The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.	Vitamin D	83-92	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	113-117
22742720-0	2012	Fibroblast growth factor 23 and parathyroid hormone after treatment with active vitamin D and sevelamer carbonate in patients with chronic kidney disease stage 3b, a randomized crossover trial.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	0-27
22742720-3	2012	The use of active vitamin D and phosphate binders as recommended in international guidelines, may affect the level of FGF23 and thereby clinical outcome.	Vitamin D	18-27	fibroblast growth factor 23	Homo sapiens	118-123
22742720-4	2012	We investigated the effects of a phosphate binder and active vitamin D on the serum levels of intact FGF23 (iFGF23) and intact parathyroid hormone (iPTH) in patients with CKD stage 3b (glomerular filtration rate (GFR) 30-44 ml/min/1.73 m(2)).	Vitamin D	61-70	fibroblast growth factor 23	Homo sapiens	101-106
22754549-1	2012	CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH).	Vitamin D	94-103	fibroblast growth factor 23	Homo sapiens	131-164
22670054-0	2012	Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.	Vitamin D	62-71	interleukin 34	Mus musculus	80-85
22670054-14	2012	The present study also suggests that the IL-34 gene in vascular endothelial cells is a unique target of vitamin D.	Vitamin D	104-113	interleukin 34	Mus musculus	41-46
22140123-8	2012	Independent predictors of rise in FGF23 were baseline levels of FGF23 (P &lt; 0.01), changes in ionized calcium (P &lt; 0.01) and phosphate (P &lt; 0.01) and cumulative dose of vitamin D analogues (P = 0.024).	Vitamin D	177-186	fibroblast growth factor 23	Homo sapiens	34-39
22180542-5	2012	From skin biopsy specimen messenger RNA (mRNA) expression levels of CYP24A1 and CYP27B1, two enzymes needed for hydroxylation of vitamin D into its active metabolites, and of antimicrobial peptide cathelicidin, were examined.	Vitamin D	129-138	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	68-75
22349668-7	2012	After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p &lt; 0.001).	Vitamin D	32-41	interleukin 10	Homo sapiens	301-320
22414425-6	2012	In keratinocyte cell cultures, the ligand-conjugated liposomes loaded with the vitamin D(3) analogue calcipotriol induced transcription of the gene encoding the antimicrobial peptide cathelicidin, which is activated through the vitamin D(3) receptor upon binding of vitamin D(3) analogues.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	228-249
22676419-6	2012	Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1.	Vitamin D	8-17	vitamin D receptor	Homo sapiens	57-75
22676419-6	2012	Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1.	Vitamin D	8-17	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	166-173
22328083-2	2012	The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) regulates gene transcription via its nuclear receptor (VDR), and posttranscriptional regulatory mechanisms of gene expression have also been proposed.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	137-140
22174178-5	2012	The PMA enhancing effect on 1,25(OH)(2)D(3) action was evident in a minimal promoter with three osteocalcin VDREs and was reduced after mutation of a putative vitamin D stimulatory site in the hCYP24A1 promoter.	Vitamin D	159-168	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	193-201
22341429-2	2012	In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells.	Vitamin D	42-51	prolactin regulatory element binding	Homo sapiens	111-116
22421156-0	2012	Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1alpha,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance.	Vitamin D	100-109	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	13-46
22421156-0	2012	Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1alpha,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance.	Vitamin D	100-109	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	48-52
22421156-5	2012	To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases.	Vitamin D	42-51	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	146-150
22421156-5	2012	To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases.	Vitamin D	42-51	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	161-165
22421156-5	2012	To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases.	Vitamin D	42-51	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	161-165
22421156-5	2012	To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases.	Vitamin D	109-118	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	146-150
22421156-5	2012	To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases.	Vitamin D	109-118	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	161-165
22421156-5	2012	To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases.	Vitamin D	109-118	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	161-165
22421156-7	2012	The results indicate that FL-HPK1 is a positive regulator of vitamin D-induced differentiation in AML cells, but the cleaved HPK1 fragment inhibits differentiation.	Vitamin D	61-70	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	29-33
22421156-8	2012	Thus, high HPK1 cleavage activity contributes to vitamin D resistance, and HPK1 has a dual role in AML cell differentiation.	Vitamin D	49-58	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	11-15
22047708-0	2012	Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL).	Vitamin D	0-9	T-box transcription factor T	Homo sapiens	58-61
22047708-5	2012	A patient stratification according to these 3 groups led to significant difference in terms of TFT, with vitamin D insufficient patients having the shortest TFT (P=0.02).	Vitamin D	105-114	T-box transcription factor T	Homo sapiens	95-98
22047708-5	2012	A patient stratification according to these 3 groups led to significant difference in terms of TFT, with vitamin D insufficient patients having the shortest TFT (P=0.02).	Vitamin D	105-114	T-box transcription factor T	Homo sapiens	157-160
22532985-2	2012	Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).	Vitamin D	68-77	vitamin D receptor	Homo sapiens	87-105
22532985-2	2012	Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).	Vitamin D	68-77	vitamin D receptor	Homo sapiens	107-110
22532985-2	2012	Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).	Vitamin D	68-77	ADAM metallopeptidase domain 33	Homo sapiens	217-252
22532985-2	2012	Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1).	Vitamin D	68-77	ADAM metallopeptidase domain 33	Homo sapiens	254-261
21972121-0	2012	Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.	Vitamin D	65-74	7-dehydrocholesterol reductase	Homo sapiens	47-52
21972121-0	2012	Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.	Vitamin D	65-74	NAD synthetase 1	Homo sapiens	53-60
21972121-7	2012	In conclusion, GC and NADSYN1/DHCR7 loci individually and collectively contribute to variation in plasma vitamin D levels in Chinese Hans.	Vitamin D	105-114	NAD synthetase 1	Homo sapiens	22-29
21972121-7	2012	In conclusion, GC and NADSYN1/DHCR7 loci individually and collectively contribute to variation in plasma vitamin D levels in Chinese Hans.	Vitamin D	105-114	7-dehydrocholesterol reductase	Homo sapiens	30-35
21871642-1	2012	The objectives of the study were to determine associations between single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene and insulin resistance and the effects of these SNPs on changes in insulin sensitivity in response to vitamin D supplementation.	Vitamin D	113-122	vitamin D receptor	Homo sapiens	133-136
21871642-9	2012	This study has highlighted the association of vitamin D responsiveness and insulin resistance with VDR gene polymorphisms.	Vitamin D	46-55	vitamin D receptor	Homo sapiens	99-102
21871642-11	2012	Genotyping of the VDR gene may provide a predictive measure for insulin resistance in response to vitamin D intervention.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	18-21
21947233-10	2012	Association between VDR polymorphisms and UTI is in accordance with the understanding of how vitamin D modulates the immune response against infections.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	20-23
21932165-0	2012	The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis.	Vitamin D	12-21	fibroblast growth factor 23	Homo sapiens	29-34
21932165-0	2012	The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis.	Vitamin D	12-21	klotho	Homo sapiens	36-42
22293059-15	2012	Furthermore, we found baseline FGF23 to predict PTH levels after 16 weeks of vitamin D analog treatment.	Vitamin D	77-86	fibroblast growth factor 23	Homo sapiens	31-36
22068926-9	2012	Further experiments demonstrated that new RNA synthesis was required for the induction of CYP24 splicing by vitamin D.	Vitamin D	108-117	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	90-95
22068926-10	2012	In addition, alteration of multiple signaling pathways also affected CYP24 splicing and cellular sensitivity in response to vitamin D appeared to correlate with the induction of CYP24 splicing.	Vitamin D	124-133	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	69-74
22068926-10	2012	In addition, alteration of multiple signaling pathways also affected CYP24 splicing and cellular sensitivity in response to vitamin D appeared to correlate with the induction of CYP24 splicing.	Vitamin D	124-133	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	178-183
22115013-8	2012	Vitamin D regulates gene expression through binding with vitamin D receptors, which dimerises with retinoid X receptor.	Vitamin D	0-9	retinoid X receptor alpha	Homo sapiens	99-118
22138541-7	2012	Thyroid hormone receptor (THR) and vitamin D receptor (VDR) pathways were also regulated in normal and disease endometrium by activation of TH or vitamin D regulated genes.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	55-58
22133546-1	2012	Selective inhibitors of CYP24A1 represent an important synthetic target in a search for novel vitamin D compounds of therapeutic value.	Vitamin D	94-103	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	24-31
21931993-1	2012	Vitamin D exerts its activity through binding to the high-affinity nuclear vitamin D receptor (VDR), and majority of genetic studies have primarily focused on variation within this gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	75-93
21931993-1	2012	Vitamin D exerts its activity through binding to the high-affinity nuclear vitamin D receptor (VDR), and majority of genetic studies have primarily focused on variation within this gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	95-98
21931993-2	2012	Therefore, analysis of genetic variation in VDR genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology in our study population.	Vitamin D	91-100	vitamin D receptor	Homo sapiens	44-47
22179700-1	2012	Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR).	Vitamin D	118-127	vitamin D receptor	Homo sapiens	154-157
22213287-1	2012	BACKGROUND: Searching for additional therapeutic tools to fight breast cancer, we investigated the effects of vitamin D-binding protein-derived macrophage activating factor (DBP-MAF, also known as GcMAF) on a human breast cancer cell line (MCF-7).	Vitamin D	110-119	GC vitamin D binding protein	Homo sapiens	174-181
22213325-3	2012	1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	126-144
22213325-3	2012	1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	146-149
22213328-3	2012	The antiproliferative effects of calcitriol [1,25(OH)(2)D(3)] mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy.	Vitamin D	79-88	vitamin D receptor	Homo sapiens	99-102
22466564-1	2012	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds to the vitamin D receptor (VDR) and regulates various physiological and pharmacological processes.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	94-112
22466564-1	2012	The active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds to the vitamin D receptor (VDR) and regulates various physiological and pharmacological processes.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	114-117
22606047-5	2012	Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis.	Vitamin D	147-156	fibroblast growth factor 23	Homo sapiens	0-27
22606047-5	2012	Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis.	Vitamin D	147-156	fibroblast growth factor 23	Homo sapiens	29-35
22606047-5	2012	Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis.	Vitamin D	147-156	fibroblast growth factor 23	Homo sapiens	29-32
22606047-6	2012	More specifically, Vitamin D stimulates FGF-23 secretion and is inhibited by increased FGF-23.	Vitamin D	19-28	fibroblast growth factor 23	Homo sapiens	40-46
22606047-6	2012	More specifically, Vitamin D stimulates FGF-23 secretion and is inhibited by increased FGF-23.	Vitamin D	19-28	fibroblast growth factor 23	Homo sapiens	87-93
22606047-7	2012	Given this background, we hypothesize that FGF-23 may provide a unique tool to explain the biphasic cardiovascular effects of vitamin D in CKD.	Vitamin D	126-135	fibroblast growth factor 23	Homo sapiens	43-49
22619734-4	2012	Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor.	Vitamin D	66-75	neurotrophin 3	Homo sapiens	337-356
22619734-4	2012	Genetic studies have helped identify a number of proteins linking vitamin D to PD pathology, including the major histocompatibility complex (MHC) class II, the vitamin D receptor (VDR), cytochrome P450 2D6 (CYP2D6), chromosome 22, the renin-angiotensin system (RAS), heme oxygenase-1 (HO-1), poly(ADP-ribose) polymerase-1 gene (PARP-1), neurotrophic factor (NTF), and Sp1 transcription factor.	Vitamin D	66-75	neurotrophin 3	Homo sapiens	358-361
23259067-0	2012	Cell-Type-Specific Effects of Silibinin on Vitamin D-Induced Differentiation of Acute Myeloid Leukemia Cells Are Associated with Differential Modulation of RXRalpha Levels.	Vitamin D	43-52	retinoid X receptor alpha	Homo sapiens	156-164
22001128-9	2012	The cancer protection often associated with high-normal vitamin D status may be attributable, in part, to the ability of the activated vitamin D receptor to decrease cox-2 expression while promoting PGE2 catabolism and suppressing the expression of PGE2 receptors.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	135-153
22298654-4	2012	FGF23 is a recently discovered hormone, predominately produced by osteoblasts/osteocytes, whose major functions are to inhibit renal tubular phosphate reabsorption and suppress circulating 1,25(OH)(2)D levels by decreasing Cyp27b1-mediated formation and stimulating Cyp24-mediated catabolism of 1,25(OH)(2)D. FGF23 participates in a new bone/kidney axis that protects the organism from excess vitamin D and coordinates renal PO(4)(3-) handling with bone mineralization/turnover.	Vitamin D	393-402	fibroblast growth factor 23	Homo sapiens	0-5
23144765-4	2012	In this pilot study, we examined whether active vitamin D (1,25(OH)(2)D(3) or calcitriol) could modulate the CD46 pathway and restore IL-10 production by CD46-costimulated CD4+ T cells from patients with MS.	Vitamin D	48-57	interleukin 10	Homo sapiens	134-139
23029160-3	2012	Exogenous vitamin D increased Ca(2+) influx and expressions of ecac and 25-hydroxyvitamin D(3)-24-hydroxylase (cyp24a1), but downregulated 1alpha-OHase (cyp27b1) with no effects on other Ca(2+) transporters.	Vitamin D	10-19	cytochrome P450, family 27, subfamily B, polypeptide 1	Danio rerio	153-160
22509365-1	2012	BACKGROUND: Previous studies have identified that variants in peroxisome proliferator-activated receptor PPAR-delta (PPARD), a target gene of vitamin D, were significantly associated with fasting glucose and insulin sensitivity in European populations.	Vitamin D	142-151	peroxisome proliferator activated receptor delta	Homo sapiens	117-122
23304521-2	2012	Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	120-138
21723567-9	2011	Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.	Vitamin D	20-29	interleukin 10	Homo sapiens	58-63
21723567-9	2011	Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.	Vitamin D	20-29	interleukin 17A	Homo sapiens	116-121
21612999-3	2011	Vitamin D effects are mediated through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	43-61
21612999-3	2011	Vitamin D effects are mediated through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	63-66
21816960-2	2011	1,25(OH)(2)D(3), the active form of vitamin D, has antiproliferative properties and antifibrotic potential, as well as a role in extracellular matrix and matrix metalloproteinase (MMP) regulation in renal and lung fibrosis.	Vitamin D	36-45	matrix metallopeptidase 9	Rattus norvegicus	180-183
22218438-1	2011	The vitamin D endocrine system comprises a group of 7-dehydrocholesterol-derived secosteroid molecules, including its active metabolite 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its precursors and other metabolites, its binding protein (DBP) and nuclear receptor (VDR), as well as cytochrome P450 complex enzymes participating in activation and inactivation pathways of those molecules.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	263-266
21550960-6	2011	RESULTS: Vitamin D therapy in the group with vitamin D deficiency led to a 26.7% decrease in BSAP (P&lt;.01).	Vitamin D	9-18	paired box 5	Homo sapiens	93-97
21550960-6	2011	RESULTS: Vitamin D therapy in the group with vitamin D deficiency led to a 26.7% decrease in BSAP (P&lt;.01).	Vitamin D	45-54	paired box 5	Homo sapiens	93-97
21550960-7	2011	Bisphosphonate therapy in the vitamin D-sufficient group led to a 32.7% decrease in BSAP (P = .01).	Vitamin D	30-39	paired box 5	Homo sapiens	84-88
21550960-9	2011	CONCLUSION: The results of this study suggest that correction of vitamin D deficiency in patients with osteopenia and osteoporosis can lead to a decrease in bone turnover as measured by BSAP and that the magnitude of this reduction is similar to that achieved with orally administered bisphosphonates.	Vitamin D	65-74	paired box 5	Homo sapiens	186-190
21803404-12	2011	CONCLUSION: Our results demonstrate how structural optimization of the vitamin-D scaffold leads to identification of a non-hypercalcemic compound MT19c which exerts cytotoxicity in vitro based on a VDR-independent signaling pathway and displays potent anti-cancer activity in ovarian cancer cell models.	Vitamin D	71-80	vitamin D receptor	Homo sapiens	198-201
21769914-3	2011	We hypothesized that the breast adipocytes express the signaling components necessary to participate in vitamin D(3) synthesis and signaling via VDR, modulating ductal epithelial cell growth and differentiation.	Vitamin D	104-113	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	145-148
21947295-2	2011	Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function.	Vitamin D	57-66	lysyl oxidase	Homo sapiens	10-13
21947295-2	2011	Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	77-80
21844150-2	2011	Vitamin D binding protein (DBP) is a highly polymorphic protein that transports vitamin D and its metabolites.	Vitamin D	80-89	GC vitamin D binding protein	Homo sapiens	0-25
22125685-1	2011	Growing evidence suggests an elevated risk for colorectal neoplasia among individuals with low levels of vitamin D, the biological actions of which are mediated by the vitamin D receptor (VDR).	Vitamin D	105-114	vitamin D receptor	Homo sapiens	168-186
22125685-1	2011	Growing evidence suggests an elevated risk for colorectal neoplasia among individuals with low levels of vitamin D, the biological actions of which are mediated by the vitamin D receptor (VDR).	Vitamin D	105-114	vitamin D receptor	Homo sapiens	188-191
21803771-4	2011	ChIP scan of the 6-kb 5" upstream region of the mouse nephrin gene identified several putative vitamin D response elements (VDREs), and EMSA confirmed that the VDRE at -312 (a DR4-type VDRE) could be bound by vitamin D receptor (VDR)/retinoid X receptor.	Vitamin D	95-104	nephrosis 1, nephrin	Mus musculus	54-61
21803771-7	2011	Treatment of mice with a vitamin D analog induced nephrin mRNA and protein in the kidney, accompanied by increased VDR binding to the -312VDRE and histone 4 acetylation.	Vitamin D	25-34	nephrosis 1, nephrin	Mus musculus	50-57
21803771-7	2011	Treatment of mice with a vitamin D analog induced nephrin mRNA and protein in the kidney, accompanied by increased VDR binding to the -312VDRE and histone 4 acetylation.	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	115-118
21735060-0	2011	SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D.	Vitamin D	59-68	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	41-46
21735060-3	2011	The present study explored whether vitamin D influences the intestinal SGLT1 activity.	Vitamin D	35-44	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	71-76
21735060-8	2011	Moreover, SGLT1 activity was increased in sgk1(+/+) mice but not in sgk1(-/-) mice following a vitamin D-rich diet.	Vitamin D	95-104	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	10-15
21735060-10	2011	In conclusion, vitamin D treatment upregulates the expression of SGK1, which in turn enhances SGLT1 activity.	Vitamin D	15-24	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	94-99
21941510-10	2011	Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.	Vitamin D	102-111	vitamin D receptor	Homo sapiens	62-65
21941510-10	2011	Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.	Vitamin D	102-111	vitamin D receptor	Homo sapiens	62-65
21675912-5	2011	Identified mutations in the vitamin D-metabolizing enzyme CYP24A1 were evaluated with the use of a mammalian expression system.	Vitamin D	28-37	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	58-65
21675912-7	2011	In addition, CYP24A1 mutations were identified in a second cohort of infants in whom severe hypercalcemia had developed after bolus prophylaxis with vitamin D.	Vitamin D	149-158	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	13-20
21675912-9	2011	CONCLUSIONS: The presence of CYP24A1 mutations explains the increased sensitivity to vitamin D in patients with idiopathic infantile hypercalcemia and is a genetic risk factor for the development of symptomatic hypercalcemia that may be triggered by vitamin D prophylaxis in otherwise apparently healthy infants.	Vitamin D	85-94	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	29-36
21675912-9	2011	CONCLUSIONS: The presence of CYP24A1 mutations explains the increased sensitivity to vitamin D in patients with idiopathic infantile hypercalcemia and is a genetic risk factor for the development of symptomatic hypercalcemia that may be triggered by vitamin D prophylaxis in otherwise apparently healthy infants.	Vitamin D	250-259	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	29-36
21561999-3	2011	We previously showed that FGFR1 is the predominant receptor for the hypophosphatemic actions of FGF23 by decreasing renal NaPi-2a and 2c expression while the receptors regulating 1,25(OH)(2)Vitamin D(3) levels remained elusive.	Vitamin D	190-199	fibroblast growth factor 23	Mus musculus	96-101
21561999-8	2011	These data indicate that FGFR3 and 4 are the receptors that regulate serum 1,25(OH)(2)Vitamin D(3) levels in response to FGF23.	Vitamin D	86-95	fibroblast growth factor 23	Mus musculus	121-126
21693626-5	2011	Multivariate logistic regression was used to evaluate associations between 19 single nucleotide polymorphisms (SNP) in vitamin D related genes, including vitamin D binding protein (GC), vitamin D receptor (VDR), and cytochrome P450 type 24A1 (CYP24A1).	Vitamin D	119-128	GC vitamin D binding protein	Homo sapiens	154-179
21697289-3	2011	Vitamin D-deficient CD4(+) T cells also overproduced IL-17 in vitro and 1,25 dihydroxyvitamin D(3) inhibited the development of T(h)17 cells in CD4(+) T-cell cultures.	Vitamin D	0-9	CD4 antigen	Mus musculus	20-23
21697289-3	2011	Vitamin D-deficient CD4(+) T cells also overproduced IL-17 in vitro and 1,25 dihydroxyvitamin D(3) inhibited the development of T(h)17 cells in CD4(+) T-cell cultures.	Vitamin D	0-9	interleukin 17A	Mus musculus	53-58
21697289-3	2011	Vitamin D-deficient CD4(+) T cells also overproduced IL-17 in vitro and 1,25 dihydroxyvitamin D(3) inhibited the development of T(h)17 cells in CD4(+) T-cell cultures.	Vitamin D	0-9	CD4 antigen	Mus musculus	144-147
21860566-1	2011	Hereditary vitamin D resistant rickets (HVDRR) is a rare genetic disorder caused by a mutation of vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	98-116
21860566-1	2011	Hereditary vitamin D resistant rickets (HVDRR) is a rare genetic disorder caused by a mutation of vitamin D receptor (VDR) gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
21504790-2	2011	However, research during the past decade provided substantial evidence that a so called "hormone-like" subgroup of FGFs, comprised of FGF19, FGF21 and FGF23, is involved in the regulation of diverse metabolic pathways to control glucose, lipid, bile acid, phosphate and vitamin D metabolism.	Vitamin D	270-279	fibroblast growth factor 23	Homo sapiens	151-156
20668935-2	2011	Effects of vitamin D are not only mediated via the vitamin D receptors by active vitamin D metabolites, but 25(OH)D(3) also acts through VDR-independent pathways directly.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	137-140
21611969-1	2011	Tumor-induced osteomalacia (TIO) is characterized by renal phosphate wasting, hypophosphatemia, and aberrant vitamin D(3) metabolism and is caused by fibroblast growth factor 23 (FGF-23)-producing mesenchymal tumors, which are often difficult to locate.	Vitamin D	109-118	fibroblast growth factor 23	Homo sapiens	179-185
21561543-1	2011	Paricalcitol is a synthetic vitamin D analogue acting on vitamin D receptor (VDR).	Vitamin D	28-37	vitamin D receptor	Homo sapiens	57-75
21561543-1	2011	Paricalcitol is a synthetic vitamin D analogue acting on vitamin D receptor (VDR).	Vitamin D	28-37	vitamin D receptor	Homo sapiens	77-80
21482732-1	2011	The vitamin D-activating enzyme 1alpha-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	85-88
21278761-2	2011	Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	48-66
21278761-2	2011	Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	68-71
21278761-2	2011	Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	92-95
21441443-6	2011	We replicated the associations of four vitamin D metabolism genes (GC, DHCR7, CYP2R1, and CYP24A1) with 25(OH)D in control subjects.	Vitamin D	39-48	7-dehydrocholesterol reductase	Homo sapiens	71-76
21244571-1	2011	BACKGROUND AND OBJECTIVE: Vitamin D regulates the production of the antimicrobial peptides cathelicidin and beta-defensin-2, which play an important role in the innate immune response to infection.	Vitamin D	26-35	defensin beta 4B	Homo sapiens	108-123
21156217-5	2011	In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p&lt;0.001), IL-23 (p=0.011), IL-10 (p=0.033) cytokine levels, TM (p=0.001) and endothelin (p=0.033) levels.	Vitamin D	26-35	interleukin 10	Homo sapiens	116-121
22704269-1	2011	The bioactive vitamin D (VD) metabolite, 1,25-dihydroxyvitamin D(3) regulates essential pathways of cellular metabolism and differentiation via its nuclear receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	166-169
21346722-3	2011	Klotho-/- mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1alpha-hydroxylase, vitamin D receptor, or NaPi cotransporter).	Vitamin D	237-246	klotho	Mus musculus	0-6
21276773-0	2011	Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure.	Vitamin D	78-87	klotho	Mus musculus	54-60
21276773-6	2011	Notably, these phenotypes were rescued by vitamin D restriction, suggesting that abnormal activation of vitamin D due to Klotho insufficiency leads to degeneration of the dopaminergic system.	Vitamin D	42-51	klotho	Mus musculus	121-127
21276773-6	2011	Notably, these phenotypes were rescued by vitamin D restriction, suggesting that abnormal activation of vitamin D due to Klotho insufficiency leads to degeneration of the dopaminergic system.	Vitamin D	104-113	klotho	Mus musculus	121-127
21276773-7	2011	The present study provides new insights into the pathology of age-related degeneration of dopaminergic neurons possibly related to Klotho-mediated regulation of vitamin D.	Vitamin D	161-170	klotho	Mus musculus	131-137
21168462-1	2011	The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	4-22
21168462-1	2011	The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	24-27
21270396-11	2011	Decreased maturation and proliferation of CD8alphaalpha(+) TCRalphabeta(+) cells in VDR KO mice results in fewer functional CD8alphaalpha(+) TCRalphabeta(+) T cells, which likely explains the increased inflammation in the gastrointestinal tract of VDR KO and vitamin D-deficient mice.	Vitamin D	259-268	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	84-87
21143012-1	2011	BACKGROUND: Since the introduction of liquid chromatography-mass spectrometry (LC/MS) for assessing vitamin D status, it has been shown that the C-3 epimer can account for a significant proportion of circulating 25-hydroxyvitamin D3 (25OHD3) concentrations in infants.	Vitamin D	100-109	complement C3	Homo sapiens	145-148
21292848-11	2011	Vitamin D sterols can improve vitamin D deficiency and PTH levels but may worsen phosphate retention and increase FGF-23 levels, and thus, may also require concomitant phosphate binder therapy.	Vitamin D	0-9	fibroblast growth factor 23	Homo sapiens	114-120
21164021-4	2011	Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene.	Vitamin D	94-103	vitamin D receptor	Homo sapiens	168-186
21503197-2	2011	Both forms of vitamin D are biologically inactive pro-hormones that must undergo sequential hydroxylations in the liver and the kidney before they can bind to and activate the vitamin D receptor.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	176-194
20431993-0	2011	Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	89-107
21256461-6	2011	Hemojuvelin knockout mice were calcitriol treated, PTH treated, vitamin D-depleted, or untreated.	Vitamin D	64-73	hemojuvelin BMP co-receptor	Mus musculus	0-11
21283672-7	2011	The functional significance of the VDR FokI polymorphism in vitamin D action is undefined.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	35-38
21283672-10	2011	The induction of the vitamin D target gene CYP24A1 mRNA was 1.8 fold higher in VDRFF cells than in VDRff cells.	Vitamin D	21-30	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	43-50
20965147-7	2011	Since high concentrations of 25-hydroxyvitamin D can bind the vitamin D receptor and can induce transcription, 25-hydroxyvitamin D is likely responsible for toxicity of vitamin D excess.	Vitamin D	39-48	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	62-80
21264318-7	2011	NPAS2 and Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/Bmal 1) were upregulated around implant and diminished by vitamin D deficiency, whereas the expression pattern of Per2 was complementary.	Vitamin D	127-136	neuronal PAS domain protein 2	Rattus norvegicus	0-5
21264318-7	2011	NPAS2 and Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/Bmal 1) were upregulated around implant and diminished by vitamin D deficiency, whereas the expression pattern of Per2 was complementary.	Vitamin D	127-136	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	10-61
21264318-7	2011	NPAS2 and Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/Bmal 1) were upregulated around implant and diminished by vitamin D deficiency, whereas the expression pattern of Per2 was complementary.	Vitamin D	127-136	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	63-68
21264318-7	2011	NPAS2 and Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/Bmal 1) were upregulated around implant and diminished by vitamin D deficiency, whereas the expression pattern of Per2 was complementary.	Vitamin D	127-136	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	69-75
20966399-2	2011	Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	0-27
20966399-2	2011	Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease.	Vitamin D	80-89	fibroblast growth factor 23	Homo sapiens	29-34
20868777-1	2011	Vitamin D deficiency may contribute to pathological changes in the number and function of CD4+ T helper cell subsets (CD4+Th1, CD4+Th17, CD4+CD25(bright)Foxp3-natural regulatory T cells-nTreg) in patients with undifferentiated connective tissue disease (UCTD).	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	122-125
20619365-2	2011	The VDR is a nuclear, ligand-induced transcription factor that regulates in complex with hormonally active vitamin D the expression of more than 900 genes involved in a wide array of physiological functions (e.g. calcium homeostasis, growth control, differentiation, cognition, immune response, etc.).	Vitamin D	107-116	vitamin D receptor	Homo sapiens	4-7
20619365-8	2011	1alpha,25(OH)2D3 levels are short-lived: the hormone upregulates its rapid metabolism by CYP24A1 that attacks repeatedly the vitamin D C20-27 side chain, thereby producing a complex cascade of transient metabolites with increasing polarity.	Vitamin D	125-134	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-96
20619365-10	2011	As selective inhibitors of CYP24A1 increase the lifetime and thereby the function of vitamin D metabolites, they will help exploring whether and which intrinsic activities distinct metabolites possess.	Vitamin D	85-94	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	27-34
21307571-3	2011	Thus, it is important to understand vitamin D biosynthesis into an active form that regulates VDR transcriptional functions.	Vitamin D	36-45	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	94-97
21307571-4	2011	The active form of vitamin D, 1alpha,25(OH)(2)D(3), derived by vitamin D3 1alpha hydroxylase, 1alpha(OH)ase in renal proximal tubule cells is a ligand for VDR.	Vitamin D	19-28	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	155-158
20795934-7	2011	Here we review molecular actions of the vitamin D receptor (VDR), to identify mechanisms and pathways for vitamin D deficiency as a universal risk factor.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	60-63
20795934-8	2011	To identify genes directly regulated by the VDR, we searched for genes containing vitamin D response elements (VDREs).	Vitamin D	82-91	vitamin D receptor	Homo sapiens	44-47
21747838-1	2011	The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases.	Vitamin D	44-53	negative elongation factor complex member C/D	Homo sapiens	130-133
21747838-1	2011	The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases.	Vitamin D	44-53	negative elongation factor complex member C/D	Homo sapiens	178-181
21760737-2	2011	This study was undertaken to assess vitamin D status in nonmenopausal women with metabolic syndrome (MeS) and to evaluate its possible role in inflammation and other components of MeS.	Vitamin D	36-45	MKS transition zone complex subunit 1	Homo sapiens	101-104
21760737-13	2011	When data were categorized according to vitamin D status, in the MeS group significantly higher plasma glucose concentrations were observed in subjects with vitamin D deficiency compared to those with insufficiency or sufficiency (104.0 +- 11.7, 83.0 +- 11.3 and 83.2 +- 9.9 mg/dL, respectively, P &lt; 0.001).	Vitamin D	40-49	MKS transition zone complex subunit 1	Homo sapiens	65-68
21760737-13	2011	When data were categorized according to vitamin D status, in the MeS group significantly higher plasma glucose concentrations were observed in subjects with vitamin D deficiency compared to those with insufficiency or sufficiency (104.0 +- 11.7, 83.0 +- 11.3 and 83.2 +- 9.9 mg/dL, respectively, P &lt; 0.001).	Vitamin D	157-166	MKS transition zone complex subunit 1	Homo sapiens	65-68
21760737-16	2011	Vitamin D status may, at least in part, be a determining factor of systemic inflammation and the related metabolic derangements of MeS.	Vitamin D	0-9	MKS transition zone complex subunit 1	Homo sapiens	131-134
21865755-3	2011	When phosphate is in excess, FGF-23 is secreted from bone and acts on the kidney to promote phosphate excretion into urine and to suppress vitamin D synthesis, thereby inducing negative phosphate balance.	Vitamin D	139-148	fibroblast growth factor 23	Homo sapiens	29-35
21197695-4	2011	Furthermore, the physiological functions with which vitamin D signalling is now associated are as diverse as the tissues in which the VDR is located.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	134-137
21747824-6	2011	These studies show that intrarenal vitamin D handling is altered in the diabetic kidney, and they suggest that in T1D, urinary losses of VDBP may portend risk for intrarenal and extrarenal vitamin D deficiencies.	Vitamin D	189-198	GC vitamin D binding protein	Homo sapiens	137-141
22219556-8	2011	Anti-inflammatory activity of vitamin D is impaired in neonatal neutrophils, and this may be due to decreased expression of VDR and 1alpha-hydroxylase.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	124-127
20855290-1	2011	The nuclear receptor vitamin D receptor (VDR) is known to associate with two vitamin D response element (VDRE) containing chromatin regions of the insulin-like growth factor binding protein 3 (IGFBP3) gene.	Vitamin D	21-30	vitamin D receptor	Homo sapiens	41-44
21829599-6	2011	We confirmed the binding of the VDR phage to active Vitamin D in vitro, as well as the higher expression of VDR in CD4+CD25+ cells.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	32-35
21351666-3	2011	The best known genes related to bone density have been identified as the genes for the vitamin D, estrogen and calcitonin receptor, LRP5 and LRP6.	Vitamin D	87-96	LDL receptor related protein 6	Homo sapiens	141-145
21234310-4	2010	Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion.	Vitamin D	63-72	klotho	Homo sapiens	5-11
21234310-4	2010	Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion.	Vitamin D	63-72	fibroblast growth factor 23	Homo sapiens	16-22
20876762-3	2010	Normally, renal reabsorption of vitamin D-binding protein-bound 25D(3) absolutely requires receptor-mediated endocytosis via a receptor complex containing megalin, cubilin, and disabled-2 (Dab2), whereas an absence of megalin or its endocytic partners can lead to a marked urinary loss of 25D and severe vitamin D deficiency.	Vitamin D	32-41	LDL receptor related protein 2	Rattus norvegicus	155-162
20876762-3	2010	Normally, renal reabsorption of vitamin D-binding protein-bound 25D(3) absolutely requires receptor-mediated endocytosis via a receptor complex containing megalin, cubilin, and disabled-2 (Dab2), whereas an absence of megalin or its endocytic partners can lead to a marked urinary loss of 25D and severe vitamin D deficiency.	Vitamin D	32-41	DAB adaptor protein 2	Rattus norvegicus	177-187
20876762-3	2010	Normally, renal reabsorption of vitamin D-binding protein-bound 25D(3) absolutely requires receptor-mediated endocytosis via a receptor complex containing megalin, cubilin, and disabled-2 (Dab2), whereas an absence of megalin or its endocytic partners can lead to a marked urinary loss of 25D and severe vitamin D deficiency.	Vitamin D	32-41	DAB adaptor protein 2	Rattus norvegicus	189-193
20876762-3	2010	Normally, renal reabsorption of vitamin D-binding protein-bound 25D(3) absolutely requires receptor-mediated endocytosis via a receptor complex containing megalin, cubilin, and disabled-2 (Dab2), whereas an absence of megalin or its endocytic partners can lead to a marked urinary loss of 25D and severe vitamin D deficiency.	Vitamin D	32-41	LDL receptor related protein 2	Rattus norvegicus	218-225
20876762-4	2010	Therefore, we hypothesized that reduced serum vitamin D status in NIDDM may be due to reduced expression of megalin and/or its endocytic partners and increased urinary excretion of protein-complexed 25D(3).	Vitamin D	46-55	LDL receptor related protein 2	Rattus norvegicus	108-115
20876762-7	2010	Taken together, these are the first reports to our knowledge that associate compromised renal reabsorption of the 25D(3)-DBP complex with expression of megalin and its endocytic partners in NIDDM, which in turn can lead to compromised vitamin D status.	Vitamin D	235-244	D-box binding PAR bZIP transcription factor	Rattus norvegicus	121-124
20876762-7	2010	Taken together, these are the first reports to our knowledge that associate compromised renal reabsorption of the 25D(3)-DBP complex with expression of megalin and its endocytic partners in NIDDM, which in turn can lead to compromised vitamin D status.	Vitamin D	235-244	LDL receptor related protein 2	Rattus norvegicus	152-159
20149622-1	2010	Mitochondrial malate dehydrogenase (mMDH) from the intestine is the NAD-linked oxidoreductase of the tricarboxylic acid cycle with the highest activity and response to vitamin D treatment in vitamin D-deficient chicks (-D).	Vitamin D	168-177	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40
20149622-1	2010	Mitochondrial malate dehydrogenase (mMDH) from the intestine is the NAD-linked oxidoreductase of the tricarboxylic acid cycle with the highest activity and response to vitamin D treatment in vitamin D-deficient chicks (-D).	Vitamin D	191-200	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40
20149622-7	2010	Data showed that either vitamin D (cholecalciferol or calcitriol) or a low Ca(2+) diet increases mMDH activity.	Vitamin D	24-33	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	97-101
20707671-1	2010	UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism.	Vitamin D	175-184	fibroblast growth factor 23	Homo sapiens	33-60
20707671-1	2010	UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism.	Vitamin D	175-184	fibroblast growth factor 23	Homo sapiens	62-68
20639756-2	2010	The studies of signaling pathways involved in the response to infection and inflammation have led to a more detailed understanding of the cellular response to Vitamin D through VDR.	Vitamin D	159-168	vitamin D receptor	Homo sapiens	177-180
20639756-3	2010	This review summarizes recent progress in understanding how Vitamin D contributes to mucosal immune function, particularly in relation to the molecular mechanisms by which Vitamin D and VDR influence mucosal immunity, bacterial infection, and inflammation.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	186-189
20639756-12	2010	Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation.	Vitamin D	141-150	vitamin D receptor	Homo sapiens	49-52
20732956-0	2010	Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term.	Vitamin D	11-20	fibroblast growth factor 23	Homo sapiens	50-55
20732956-0	2010	Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term.	Vitamin D	74-83	fibroblast growth factor 23	Homo sapiens	50-55
20732956-7	2010	RESULTS: Serum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group.	Vitamin D	64-73	fibroblast growth factor 23	Homo sapiens	15-20
20732956-7	2010	RESULTS: Serum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	15-20
20732956-8	2010	Serum FGF23 and phosphate concentrations further decreased significantly during replacement of vitamin D (P&lt;0.05).	Vitamin D	95-104	fibroblast growth factor 23	Homo sapiens	6-11
20732956-9	2010	A significant negative correlation was evident between FGF23 and PTH before vitamin D replacement in the patients (r=-0.469, P&lt;0.05).	Vitamin D	76-85	fibroblast growth factor 23	Homo sapiens	55-60
20732956-10	2010	CONCLUSION: Decreased FGF23 concentrations, which further decline during vitamin D replacement therapy, may have favorable action on bone mineralization by counterregulatory effect on phosphate homeostasis.	Vitamin D	73-82	fibroblast growth factor 23	Homo sapiens	22-27
20732956-11	2010	Lower 1,25(OH)2D concentrations at baseline and hypophosphatemia during treatment may have dominating effects on FGF23 concentrations in vitamin D deficiency, leading to decreased FGF23 concentrations at baseline and during replacement therapy.	Vitamin D	137-146	fibroblast growth factor 23	Homo sapiens	113-118
20658451-5	2010	In patients undergoing dialysis, FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D therapy, but fail to suppress the secretion of parathyroid hormone, presumably due to decreased expression of the Klotho-FGFR1 complex.	Vitamin D	112-121	fibroblast growth factor 23	Homo sapiens	33-38
20883026-2	2010	We have identified an o-aminoanilide analogue of the hormonal form of vitamin D with a dienyl side chain that functions as a strong VDR antagonist.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	132-135
20638491-12	2010	OPG treatment inhibited bone turnover and caused an increase in PTH levels, while tumor burden was reduced by 90.4% in vitamin D sufficient mice and by 92.6% in vitamin D deficient mice.	Vitamin D	161-170	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	0-3
20605845-3	2010	The activated vitamin D brings about its actions through the vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	61-79
20605845-3	2010	The activated vitamin D brings about its actions through the vitamin D receptor (VDR).	Vitamin D	14-23	vitamin D receptor	Homo sapiens	81-84
20890434-7	2010	Based on the present results, therapies targeting the activity of TLRs, AMPs and vitamin D, including modulation of the TLR-VDR pathways, might provide new therapeutic approaches to the psoriasis and other inflammatory skin diseases.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	124-127
20723601-6	2010	Vitamin D(3) metabolites increased ALP activity and induced mineralization when osteogenic supplements (OS; l-ascorbic acid-2-phosphate+beta-glycerophosphate) were added, though the expression of osteocalcin (OC) and osteopontin (OPN) were regulated without the addition of OS.	Vitamin D	0-9	ATHS	Homo sapiens	35-38
20723601-7	2010	CYP24 and CYP27B1 expressions were upregulated by vitamin D(3) metabolites and 25OHD(3) was converted into 1alpha,25(OH)(2)D(3) in the culture medium.	Vitamin D	50-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-5
20733005-1	2010	Hormonal vitamin D, 1,25-dihydroxyvitamin D (1,25D), signals through the nuclear vitamin D receptor (VDR).	Vitamin D	9-18	vitamin D receptor	Homo sapiens	81-99
20733005-1	2010	Hormonal vitamin D, 1,25-dihydroxyvitamin D (1,25D), signals through the nuclear vitamin D receptor (VDR).	Vitamin D	9-18	vitamin D receptor	Homo sapiens	101-104
20798257-8	2010	FGF23 plays a central role in vitamin D metabolism: It inhibits calcitriol synthesis in the kidney and stimulates the catabolism of active vitamin D sterols.	Vitamin D	30-39	fibroblast growth factor 23	Homo sapiens	0-5
20798257-8	2010	FGF23 plays a central role in vitamin D metabolism: It inhibits calcitriol synthesis in the kidney and stimulates the catabolism of active vitamin D sterols.	Vitamin D	139-148	fibroblast growth factor 23	Homo sapiens	0-5
20667908-3	2010	In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR).	Vitamin D	138-147	vitamin D receptor	Homo sapiens	282-300
20667908-3	2010	In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR).	Vitamin D	138-147	vitamin D receptor	Homo sapiens	302-305
20450955-1	2010	The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	83-86
20450955-1	2010	The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	88-106
20450955-1	2010	The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	83-86
20450955-1	2010	The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription.	Vitamin D	57-66	vitamin D receptor	Homo sapiens	88-106
20805994-13	2010	Aberration of normal homeostasis of Vitamin D, of which approximately 90% is bound to vitamin D-binding protein, has been widely implicated in MScl for some years now.	Vitamin D	36-45	GC vitamin D binding protein	Homo sapiens	86-111
20628264-1	2010	OBJECTIVE: Vitamin D has been shown to have multiple biological targets mediated by the vitamin D receptor present in many cells.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	88-106
20399147-6	2010	Our results suggest that the down-regulation of ICAM-1 and LFA-1 on PBMC and the inhibition of MMP-9 activity by ZK could provide a potential role of this low calcemic vitamin D derivative in future strategies in IBD therapy.	Vitamin D	168-177	matrix metallopeptidase 9	Homo sapiens	95-100
20171278-0	2010	Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone.	Vitamin D	122-131	vitamin D receptor	Homo sapiens	28-31
20171278-0	2010	Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone.	Vitamin D	122-131	retinoid X receptor alpha	Homo sapiens	32-35
20171278-1	2010	The vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in target cells and tissues by orchestrating the expression of gene networks responsible for vitamin D-induced phenotypes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
20227497-3	2010	Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	197-200
20227497-3	2010	Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	197-200
20403435-1	2010	In the nuclear receptor of vitamin D (VDR) histidine 305 participates to the anchoring of the ligand.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	38-41
20403435-2	2010	The VDR H305Q mutation was identified in a patient who exhibited the hereditary vitamin D-resistant rickets (HVDRR).	Vitamin D	80-89	vitamin D receptor	Homo sapiens	4-7
20536781-0	2010	Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	51-69
20236932-1	2010	CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter.	Vitamin D	52-61	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
20236932-1	2010	CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	89-107
20236932-1	2010	CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	109-112
20236932-1	2010	CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter.	Vitamin D	52-61	retinoid X receptor alpha	Homo sapiens	114-133
20236932-1	2010	CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter.	Vitamin D	52-61	retinoid X receptor alpha	Homo sapiens	135-138
20236932-8	2010	We conclude that a more complex mechanism is responsible for the striking CYP24A1 up-regulation induced by the vitamin D hormone in target cells.	Vitamin D	111-120	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	74-81
20349229-9	2010	Calcium and vitamin D yielded greater and more significant effects on all variables (except ALP) than either treatment alone.	Vitamin D	12-21	ATHS	Homo sapiens	92-95
19888899-2	2010	The actions of vitamin D are mediated through the nuclear vitamin D receptor (VDR), and gene disruption of the VDR in mice causes skeletal disorders.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-76
19888899-2	2010	The actions of vitamin D are mediated through the nuclear vitamin D receptor (VDR), and gene disruption of the VDR in mice causes skeletal disorders.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	78-81
19888899-2	2010	The actions of vitamin D are mediated through the nuclear vitamin D receptor (VDR), and gene disruption of the VDR in mice causes skeletal disorders.	Vitamin D	15-24	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	111-114
20090765-5	2010	However, 1,25(OH)(2) vitamin D(3), 9-cis retinoic acid (RA), and 13-cis RA also induced the KLKs, but the timing and pattern of KLK induction for each were different and distinct from changes in differentiation markers.	Vitamin D	21-30	kallikrein related peptidase 4	Homo sapiens	92-96
20303786-2	2010	The CaR regulates the release of parathyroid hormone (PTH) in response to changes in extracellular calcium, whereas the VDR mediates the effects of calcitriol, the active metabolite of vitamin D.	Vitamin D	185-194	vitamin D receptor	Homo sapiens	120-123
20435872-0	2010	The vitamin D axis in the lung: a key role for vitamin D-binding protein.	Vitamin D	4-13	GC vitamin D binding protein	Homo sapiens	47-72
20435872-1	2010	There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin).	Vitamin D	55-64	vitamin D receptor	Homo sapiens	113-131
20435872-1	2010	There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin).	Vitamin D	55-64	vitamin D receptor	Homo sapiens	133-136
20435872-1	2010	There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin).	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	142-167
20435872-1	2010	There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin).	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	169-173
20398021-1	2010	The bioactive form of vitamin D, 1,25-dihydroxyvitamin D(3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	104-122
20398021-1	2010	The bioactive form of vitamin D, 1,25-dihydroxyvitamin D(3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	124-127
20197072-3	2010	FGF23 also reduces serum vitamin D levels to suppress phosphate absorption from intestine.	Vitamin D	25-34	fibroblast growth factor 23	Mus musculus	0-5
20144976-1	2010	BACKGROUND: Vitamin D binding protein (DBP) acts as a vitamin D carrier and an actin scavenger.	Vitamin D	54-63	GC vitamin D binding protein	Homo sapiens	12-37
20133492-5	2010	VDR agonists effectively treat SHPT and vitamin D deficiency, but dosing needs to be optimized for each patient because the patient responds in an individualized manner to treatment to suppress and stabilize PTH levels.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	0-3
20020446-0	2010	Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D.	Vitamin D	85-94	matrix metallopeptidase 9	Homo sapiens	16-21
20020446-12	2010	By down-regulating MMP-9 levels active vitamin D derivatives may attenuate deleterious effects due to excessive TNFalpha-induced proteolytic activity associated with cutaneous inflammation.	Vitamin D	39-48	matrix metallopeptidase 9	Homo sapiens	19-24
20172224-10	2010	Vitamin D status of cattle might be important for optimal innate immune function because 1,25(OH)(2)D(3) production in activated monocytes and subsequent upregulation of inducible nitric oxide synthase and RANTES expression was dependent on 25(OH)D(3) availability.	Vitamin D	0-9	nitric oxide synthase 2	Bos taurus	170-201
19951695-3	2010	The discovery of VDR in a number of different cell and tissue types, suggests that the physiological role of vitamin D may extend beyond the regulation of calcium homeostasis and bone function.	Vitamin D	109-118	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	17-20
19961935-0	2010	Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity.	Vitamin D	0-9	cyclin dependent kinase 2	Rattus norvegicus	118-122
20963568-6	2010	Unexpectedly, alendronate at 10(-7) and 10(-5) M concentrations increased the RANKL expression with the presence of vitamin D in differentiated hOB and this induction of RANKL mRNA levels by alendronate was dose-dependent.	Vitamin D	116-125	TNF superfamily member 11	Homo sapiens	78-83
20963568-8	2010	Thus, we conclude that alendronate does not affect the ALP activity and OPG gene expression in differentiated hOB, but may increase RANKL gene expression induced by vitamin D.	Vitamin D	165-174	TNF superfamily member 11	Homo sapiens	132-137
19756714-2	2010	Klotho is a coactivator of FGF23, a regulator of phosphate and vitamin D metabolism.	Vitamin D	63-72	klotho	Homo sapiens	0-6
19756714-2	2010	Klotho is a coactivator of FGF23, a regulator of phosphate and vitamin D metabolism.	Vitamin D	63-72	fibroblast growth factor 23	Homo sapiens	27-32
21139376-3	2010	Liganded VDR heterodimerizes with the retinoid X receptor and interacts with a vitamin D response element (VDRE).	Vitamin D	79-88	vitamin D receptor	Homo sapiens	9-12
21139376-3	2010	Liganded VDR heterodimerizes with the retinoid X receptor and interacts with a vitamin D response element (VDRE).	Vitamin D	79-88	retinoid X receptor alpha	Homo sapiens	38-57
20527229-2	2010	This tissue-specific expression of 24-OHase may act as a pivotal link between vitamin D status (25(OH)D3 level) and the anticancer effects of 1,25(OH)2D3.	Vitamin D	78-87	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	35-43
20049159-1	2010	Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR).	Vitamin D	41-50	vitamin D receptor	Homo sapiens	61-64
20049159-1	2010	Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR).	Vitamin D	41-50	retinoid X receptor alpha	Homo sapiens	114-133
20049159-1	2010	Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR).	Vitamin D	41-50	retinoid X receptor alpha	Homo sapiens	135-138
20049159-5	2010	RXRA polymorphisms, located 3" of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, while RXRA polymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods.	Vitamin D	94-103	retinoid X receptor alpha	Homo sapiens	0-4
20049159-6	2010	Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake.	Vitamin D	115-124	retinoid X receptor alpha	Homo sapiens	37-41
19801650-1	2009	(23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	136-154
19801650-1	2009	(23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	156-160
20003316-2	2009	Vitamin D is now recognised as having pleiotropic roles beyond bone and mineral homeostasis, with the vitamin D receptor and metabolising machinery identified in multiple tissues.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	102-120
19779013-0	2009	Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption.	Vitamin D	28-37	transient receptor potential cation channel subfamily V member 6	Homo sapiens	53-58
19777446-11	2009	The compensatory TRPV6 transcripts in KO mice may be modulated by endogenous vitamin D(3) via other factors of VDR signaling complexes.	Vitamin D	77-86	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	111-114
19545951-7	2009	Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	55-73
19545951-7	2009	Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	75-78
19631778-1	2009	Vitamin D plays a major role in mineral and skeletal homeostasis through interaction with the nuclear vitamin D receptor (VDR) of target cells.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	102-120
19631778-1	2009	Vitamin D plays a major role in mineral and skeletal homeostasis through interaction with the nuclear vitamin D receptor (VDR) of target cells.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	122-125
19555782-1	2009	Fibroblast growth factor 23 (FGF23) is a humoral factor that is produced by osteocytes and regulates phosphate and vitamin D metabolism.	Vitamin D	115-124	fibroblast growth factor 23	Homo sapiens	0-27
19555782-1	2009	Fibroblast growth factor 23 (FGF23) is a humoral factor that is produced by osteocytes and regulates phosphate and vitamin D metabolism.	Vitamin D	115-124	fibroblast growth factor 23	Homo sapiens	29-34
19753122-2	2009	Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	67-85
19753122-2	2009	Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	87-90
19753122-3	2009	Therefore, analysis of genetic variation in VDR and other vitamin D pathway genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology.	Vitamin D	119-128	vitamin D receptor	Homo sapiens	44-47
19758226-2	2009	Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	153-171
19758226-2	2009	Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes.	Vitamin D	121-130	vitamin D receptor	Homo sapiens	173-176
19667142-4	2009	On a genomic level, these pathways converge on regulatory modules, some of which contain VDR-binding sites, so-called vitamin D response elements (VDREs).	Vitamin D	118-127	vitamin D receptor	Homo sapiens	89-92
19667148-1	2009	BACKGROUND: Vitamin D analog, 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha(OH)D5), is a less toxic VDR agonist that suppresses proliferation of breast cancer cells in vitro and in vivo.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	102-105
19667171-5	2009	RESULTS: In a mouse model fed low (0.04%) nutritional calcium, expression of the vitamin D catabolizing CYP24A1, of the synthesizing CYP27B1 hydroxylase and of the vitamin D receptor was induced in the right colon only.	Vitamin D	81-90	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	104-111
19488670-3	2009	As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to maintain calcium homeostasis through the vitamin D endocrine system.	Vitamin D	145-154	GC vitamin D binding protein	Homo sapiens	49-74
19502595-1	2009	Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)).	Vitamin D	71-80	vitamin D receptor	Homo sapiens	0-18
19502595-1	2009	Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)).	Vitamin D	71-80	vitamin D receptor	Homo sapiens	20-23
18829283-1	2009	The hormone 1,25 dihydroxyvitamin D (1,25(OH)(2)D) binds to the nuclear vitamin D receptor (nVDR), which heterodimerizes with retinoid X receptor alpha (RXRalpha), and this complex interacts with specific response elements [vitamin D response elements (VDREs)] to regulate gene transcription.	Vitamin D	26-35	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	72-90
19414624-8	2009	Higher protein expression of CYP3A4, MRP2, P-gp, and MRP4 was also observed after a 6-day treatment with other vitamin D analogs (100 nM 1alpha-hydroxyvitamin D(3),1alpha-hydroxyvitamin D(2) or Hectorol, and 25-hydroxyvitamin D(3)) in Caco-2 cells, suggesting a role of 1,25(OH)(2)D(3) and analogs in the activation of enzymes and transporters via the vitamin D receptor.	Vitamin D	111-120	ATP binding cassette subfamily C member 2	Homo sapiens	37-41
19414624-8	2009	Higher protein expression of CYP3A4, MRP2, P-gp, and MRP4 was also observed after a 6-day treatment with other vitamin D analogs (100 nM 1alpha-hydroxyvitamin D(3),1alpha-hydroxyvitamin D(2) or Hectorol, and 25-hydroxyvitamin D(3)) in Caco-2 cells, suggesting a role of 1,25(OH)(2)D(3) and analogs in the activation of enzymes and transporters via the vitamin D receptor.	Vitamin D	111-120	ATP binding cassette subfamily C member 4	Homo sapiens	53-57
19414624-8	2009	Higher protein expression of CYP3A4, MRP2, P-gp, and MRP4 was also observed after a 6-day treatment with other vitamin D analogs (100 nM 1alpha-hydroxyvitamin D(3),1alpha-hydroxyvitamin D(2) or Hectorol, and 25-hydroxyvitamin D(3)) in Caco-2 cells, suggesting a role of 1,25(OH)(2)D(3) and analogs in the activation of enzymes and transporters via the vitamin D receptor.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	352-370
19623255-7	2009	All vitamin D analogs tested blocked IL-17A induced HBD2 expression by increasing IkappaB-alpha protein and inhibition of NF-kappaB signaling.	Vitamin D	4-13	interleukin 17A	Homo sapiens	37-43
19623255-8	2009	At the same time vitamin D analogs induced cathelicidin through activation of the vitamin D receptor and MEK/ERK signaling.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	82-100
19607716-3	2009	An ancient primate-specific Alu short interspersed element (SINE) put the human CAMP gene under the regulation of the vitamin D pathway by providing a perfect vitamin D receptor binding element (VDRE) in its promoter.	Vitamin D	118-127	vitamin D receptor	Homo sapiens	159-177
19298386-0	2009	Evidence for beta-lactoglobulin involvement in vitamin D transport in vivo--role of the gamma-turn (Leu-Pro-Met) of beta-lactoglobulin in vitamin D binding.	Vitamin D	47-56	beta-lactoglobulin	Bos taurus	13-31
19298386-0	2009	Evidence for beta-lactoglobulin involvement in vitamin D transport in vivo--role of the gamma-turn (Leu-Pro-Met) of beta-lactoglobulin in vitamin D binding.	Vitamin D	138-147	beta-lactoglobulin	Bos taurus	116-134
19298386-1	2009	Beta-lactoglobulin (LG) is a major bovine milk protein, containing a central calyx and a second exosite beyond the calyx to bind vitamin D; however, the biological function of LG in transporting vitamin D remains elusive.	Vitamin D	129-138	beta-lactoglobulin	Bos taurus	0-18
19298386-1	2009	Beta-lactoglobulin (LG) is a major bovine milk protein, containing a central calyx and a second exosite beyond the calyx to bind vitamin D; however, the biological function of LG in transporting vitamin D remains elusive.	Vitamin D	195-204	beta-lactoglobulin	Bos taurus	0-18
19254681-5	2009	RESULTS: Transgenic expression of VDR in the intestine of VDR-knockout mice normalized duodenal vitamin D-regulated calcium absorption as well as vitamin D-regulated calcium binding protein D9k and TRPV6 gene expression in the duodenum and proximal colon.	Vitamin D	96-105	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	34-37
19254681-5	2009	RESULTS: Transgenic expression of VDR in the intestine of VDR-knockout mice normalized duodenal vitamin D-regulated calcium absorption as well as vitamin D-regulated calcium binding protein D9k and TRPV6 gene expression in the duodenum and proximal colon.	Vitamin D	96-105	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	58-61
19254681-5	2009	RESULTS: Transgenic expression of VDR in the intestine of VDR-knockout mice normalized duodenal vitamin D-regulated calcium absorption as well as vitamin D-regulated calcium binding protein D9k and TRPV6 gene expression in the duodenum and proximal colon.	Vitamin D	146-155	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	34-37
19049339-1	2009	Hereditary vitamin D-resistant rickets (HVDRR) is a rare recessive genetic disorder caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	111-129
19049339-1	2009	Hereditary vitamin D-resistant rickets (HVDRR) is a rare recessive genetic disorder caused by mutations in the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	41-44
19429444-1	2009	The active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a potent ligand for the nuclear receptor vitamin D receptor (VDR) and induces myeloid leukemia cell differentiation.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	128-146
19429444-1	2009	The active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a potent ligand for the nuclear receptor vitamin D receptor (VDR) and induces myeloid leukemia cell differentiation.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	148-151
19193059-0	2009	A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor.	Vitamin D	15-24	lipopolysaccharide binding protein	Homo sapiens	79-100
18398421-1	2009	BACKGROUND AND OBJECTIVES: Vitamin D and its metabolites act through vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	69-87
18398421-1	2009	BACKGROUND AND OBJECTIVES: Vitamin D and its metabolites act through vitamin D receptor (VDR).	Vitamin D	27-36	vitamin D receptor	Homo sapiens	89-92
18981260-2	2009	In the absence of vitamin D(3), PXR activates the CYP24A1 gene by directly binding to and transactivating vitamin D-response elements (VDREs) within its promoter.	Vitamin D	106-115	nuclear receptor subfamily 1, group I, member 2	Mus musculus	32-35
18981260-2	2009	In the absence of vitamin D(3), PXR activates the CYP24A1 gene by directly binding to and transactivating vitamin D-response elements (VDREs) within its promoter.	Vitamin D	106-115	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	50-57
18981260-3	2009	Vitamin D(3) activates the CYP24A1 promoter by dissociating the corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D receptor (VDR) on those VDREs.	Vitamin D	0-9	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	27-34
18981260-3	2009	Vitamin D(3) activates the CYP24A1 promoter by dissociating the corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D receptor (VDR) on those VDREs.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	154-172
18981260-3	2009	Vitamin D(3) activates the CYP24A1 promoter by dissociating the corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D receptor (VDR) on those VDREs.	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	174-177
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	23-32	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-3
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	23-32	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	54-61
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	23-32	nuclear receptor subfamily 1, group I, member 2	Mus musculus	77-80
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	23-32	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	167-174
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	114-123	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-3
18981260-4	2009	PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter.	Vitamin D	114-123	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	54-61
19818218-5	2009	The VDR complex binds in the nucleus to the vitamin D responsive element on the gene.	Vitamin D	44-53	vitamin D receptor	Homo sapiens	4-7
19124512-1	2009	BACKGROUND: Vitamin D is hypothesized to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	122-140
19124512-1	2009	BACKGROUND: Vitamin D is hypothesized to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	142-145
19494615-5	2009	The hormonally active form of vitamin D (1,25(OH)-D(3) or calcitriol) mediates its biological effects by binding to the vitamin D receptor, which then translocates to the nuclei of the cell and binds to specific DNA sites to modify the expression of target genes.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	120-138
22276021-2	2009	BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	154-172
22276021-2	2009	BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	174-177
22276021-2	2009	BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR).	Vitamin D	78-87	vitamin D receptor	Homo sapiens	154-172
22276021-2	2009	BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR).	Vitamin D	78-87	vitamin D receptor	Homo sapiens	174-177
22276021-12	2009	In an Italian study, we found that 85% of the participants had insufficient levels of 25(OH)D. We have shown through a meta-analysis of randomized trials that vitamin D supplementation is associated with a significant reduction (7%) in total mortality in healthy subjects and an association between VDR and 25(OH)D and CMM progression has also been demonstrated.	Vitamin D	159-168	vitamin D receptor	Homo sapiens	299-302
19301089-11	2009	In group 1 (risedronate plus calcium/vitamin D-treated patients), serum levels of RANKL and IL-1beta significantly decreased and the level of osteoprotegerin significantly increased after three and 6 months, but no significant difference was found in TNF-alpha level.	Vitamin D	37-46	TNF superfamily member 11	Homo sapiens	82-87
18957950-2	2009	These include the discovery that the calcium-sensing receptor has an important role in the regulation of parathyroid gland function, the development of calcimimetics to target this receptor, the recognition that vitamin D receptor activation has important functions beyond the regulation of mineral metabolism, the identification of the phosphaturic factor fibroblast growth factor 23 and the contribution of this hormone to disordered phosphate and vitamin D metabolism in CKD.	Vitamin D	212-221	fibroblast growth factor 23	Homo sapiens	357-384
19820750-1	2009	FGF23 is a recently identified hormone regulating mineral and vitamin D metabolism.	Vitamin D	62-71	fibroblast growth factor 23	Homo sapiens	0-5
19820750-4	2009	FGF23 can also be used as a predictor of mortality as well as future development of refractory hyperparathyroidism in patients undergoing dialysis therapy, where FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D treatment.	Vitamin D	241-250	fibroblast growth factor 23	Homo sapiens	0-5
19820750-4	2009	FGF23 can also be used as a predictor of mortality as well as future development of refractory hyperparathyroidism in patients undergoing dialysis therapy, where FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D treatment.	Vitamin D	241-250	fibroblast growth factor 23	Homo sapiens	162-167
20010502-3	2009	The restriction polymorphisms in VDR gene could be involved in the modulation of vitamin D action and modulate the level of bone mineral density (BMD) and the risk to develop osteopenia and osteoporosis.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	33-36
20169924-1	2009	Vitamin D-binding protein (DBP) participates in the actin scavenger system, it is a carrier of vitamin D and its derivatives, it manifests the capacity to bind mainly monounsaturated and saturated fatty acids, it binds to the surface of several cells and enhances chemotactic activity of C5a of the complement.	Vitamin D	95-104	GC vitamin D binding protein	Homo sapiens	0-25
18644400-0	2008	Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential.	Vitamin D	20-29	vitamin D receptor	Homo sapiens	67-70
19015318-1	2008	The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	177-195
19015318-1	2008	The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	197-200
18824104-0	2008	A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression.	Vitamin D	17-26	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	51-58
18824104-5	2008	Here we report the identification of six novel SNPs in the human CYP24A1 promoter, including one at nucleotide -279 occurring within the distal vitamin D response element (VDRE2).	Vitamin D	144-153	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	65-72
18810375-5	2008	The ratio of osteoclast stimulating RANKL and its soluble decoy receptor OPG is modulated by sex hormones, vitamin D, parathyroid hormone, local growth factors and mechanical loading.	Vitamin D	107-116	TNF superfamily member 11	Homo sapiens	36-41
18844849-4	2008	The remarkable range of the effects of vitamin D relates to our new understanding of both the role of the vitamin D receptor and analyses of what might be considered an optimum vitamin D status in populations exposed to very different diets and levels of sun exposure.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	106-124
18567002-8	2008	Furthermore, treatment of ovarian cancer cells with vitamin D or a selenium compound resulted in re-expression of PDEF, downregulation of survivin, induction of apoptosis and inhibition of tumor cell growth when compared to untreated controls (p &lt; 0.05).	Vitamin D	52-61	SAM pointed domain containing ETS transcription factor	Homo sapiens	114-118
18647306-1	2008	BACKGROUND: Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	150-153
18758137-7	2008	1alpha-Methyl-2alpha-(3-hydroxypropyl)-25-hydroxyvitamin D(3) improved the binding affinity for the mutant VDR(Arg274Leu), which causes hereditary vitamin D resistant rickets.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	107-110
18591745-5	2008	Recent studies suggest that FGF23 plays a certain role in premature aging process through altered P and vitamin D metabolism.	Vitamin D	104-113	fibroblast growth factor 23	Homo sapiens	28-33
18068275-1	2008	The QSAR is an alternative method for the research of new and better Vitamin D analogues with affinity for the VDR receptor.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	111-114
18068275-2	2008	This paper describes the results of applying the Radial Distribution Function (RDF descriptors) approach for predicting the VDR affinity of 38 vitamin D analogues.	Vitamin D	143-152	vitamin D receptor	Homo sapiens	124-127
18515093-2	2008	1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the hormonal form of vitamin D, is involved in the anti-inflammatory action through VDR.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	130-133
18426327-0	2008	Vitamin D-dependent rickets type II: report of a novel mutation in the vitamin D receptor gene.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	71-89
18426327-1	2008	Hereditary vitamin D-resistant rickets type or vitamin D-dependent rickets type II is a genetically determined and rare autosomal recessive disorder, most often caused by mutations in the vitamin D receptor gene.	Vitamin D	11-20	vitamin D receptor	Homo sapiens	188-206
18426327-1	2008	Hereditary vitamin D-resistant rickets type or vitamin D-dependent rickets type II is a genetically determined and rare autosomal recessive disorder, most often caused by mutations in the vitamin D receptor gene.	Vitamin D	47-56	vitamin D receptor	Homo sapiens	188-206
18483332-2	2008	The active metabolite of vitamin D, 1,25-dihydroxycholecalciferol (calcitriol), has been shown to have antiproliferative effects in several tumor types, mediated by the vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	169-187
18483332-2	2008	The active metabolite of vitamin D, 1,25-dihydroxycholecalciferol (calcitriol), has been shown to have antiproliferative effects in several tumor types, mediated by the vitamin D receptor (VDR).	Vitamin D	25-34	vitamin D receptor	Homo sapiens	189-192
18200516-0	2008	Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients.	Vitamin D	0-9	intercellular adhesion molecule 1	Homo sapiens	56-62
18200516-9	2008	The treatment with the vitamin D derivatives, alone or in combination with LPS or TNF-alpha, significantly decreases ICAM-1 levels both in healthy subjects and IBD patients.	Vitamin D	23-32	intercellular adhesion molecule 1	Homo sapiens	117-123
18207369-0	2008	Vitamin D(3) inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis.	Vitamin D	0-9	dystonin	Homo sapiens	36-64
18287530-6	2008	These findings strongly suggest that claudin-2- and/or claudin-12-based tight junctions form paracellular Ca(2+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis.	Vitamin D	191-200	claudin 12	Homo sapiens	55-65
18454815-4	2008	The remarkable range of the effects of vitamin D relates to our new understanding of both the role of the vitamin D receptor and analyses of what might be considered an optimum vitamin D status in populations exposed to very different diets and levels of sun exposure.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	106-124
18467787-2	2008	The enzyme CYP24 inactivates vitamin D and is involved in its regulation.	Vitamin D	29-38	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	11-16
18467787-14	2008	CONCLUSION: Mechanical stress and MAPK control CYP24 promoter activity in the presence of Vitamin D in MG63 osteoblast-like cells.	Vitamin D	90-99	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	47-52
18379402-1	2008	STUDY DESIGN: Human lumbar anulus tissue and cultured human lumbar anulus cells were used in retrospective studies of the immunocytochemical localization of the vitamin D receptor (VDR) in disc tissue, and of the in vitro effects of the active metabolite of vitamin D, 1,25(OH)2D3, on anulus cell proliferation, cytokine, and proteoglycan (PG) production.	Vitamin D	161-170	vitamin D receptor	Homo sapiens	181-184
18182164-3	2008	Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR).	Vitamin D	45-54	vitamin D receptor	Homo sapiens	92-110
18182164-3	2008	Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR).	Vitamin D	45-54	vitamin D receptor	Homo sapiens	112-115
18177265-2	2008	The klotho gene encodes a single-pass transmembrane protein that binds to multiple fibroblast growth factor (FGF) receptors and functions as a co-receptor for FGF23, a bone-derived hormone that suppresses phosphate reabsorption and vitamin D biosynthesis in the kidney.	Vitamin D	232-241	klotho	Mus musculus	4-10
18177265-2	2008	The klotho gene encodes a single-pass transmembrane protein that binds to multiple fibroblast growth factor (FGF) receptors and functions as a co-receptor for FGF23, a bone-derived hormone that suppresses phosphate reabsorption and vitamin D biosynthesis in the kidney.	Vitamin D	232-241	fibroblast growth factor 23	Mus musculus	159-164
18177265-6	2008	Thus, understanding of Klotho protein function is expected to provide new insights into the molecular basis for aging, phosphate/vitamin D metabolism, cancer and stem cell biology.	Vitamin D	129-138	klotho	Mus musculus	23-29
18429807-2	2008	Hypocalcemic vitamin D-resistant rickets represents a specific type of rickets that is attributed to vitamin D receptor defect rather than to vitamin D deficiency.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	101-119
17850211-6	2008	These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.	Vitamin D	186-195	transient receptor potential cation channel subfamily V member 6	Homo sapiens	52-57
17850211-6	2008	These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.	Vitamin D	186-195	carbonic anhydrase 2	Homo sapiens	131-134
18491455-3	2008	Vitamin D exerts its effects through the Vitamin D Receptor, coded for by a gene showing several polymorphisms associated with a variety of diseases and differential responses to Vitamin D.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	41-59
18161000-2	2008	Vitamin D is a known immune system modulator and its effects are exerted via the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	81-99
18161000-2	2008	Vitamin D is a known immune system modulator and its effects are exerted via the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	101-104
18365588-0	2008	Vitamin D receptor gene polymorphisms in Turkish children with vitamin D deficient rickets.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	0-18
18365588-2	2008	In order to check whether vitamin D receptor (VDR) gene polymorphism relates to the vitamin D deficient rickets, we analyzed VDR gene FokI, TaqI and ApaI polymorphisms in 24 Turkish vitamin D deficient rickets patients and 100 healthy controls.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	46-49
18365588-5	2008	Our results indicated that VDR gene polymorphisms might be an important factor for genetic susceptibility to vitamin D deficient rickets in the Turkish population.	Vitamin D	109-118	vitamin D receptor	Homo sapiens	27-30
18998068-2	2008	In addition, bile acids may play a role in colorectal cancer pathogenesis because they reduce the chemopreventive efficiency of calcium and vitamin D by interfering with calcium and vitamin D receptor-activated anti-mitogenic intracellular signalling in neoplastic colonocytes.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	182-200
18290711-8	2007	The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action.	Vitamin D	278-287	vitamin D receptor	Homo sapiens	49-52
18290711-8	2007	The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action.	Vitamin D	278-287	vitamin D receptor	Homo sapiens	223-226
18290711-8	2007	The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action.	Vitamin D	278-287	vitamin D receptor	Homo sapiens	223-226
18290714-7	2007	In the TRPV6 gene, these enhancers were all located within 5 kb of the transcriptional start site (TSS), and each contained one or more vitamin D regulatory elements (VDREs).	Vitamin D	136-145	transient receptor potential cation channel subfamily V member 6	Homo sapiens	7-12
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	109-127
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	129-132
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	154-173
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	175-178
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	109-127
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	129-132
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	37-46	retinoid X receptor alpha	Homo sapiens	154-173
18290715-1	2007	The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes.	Vitamin D	37-46	retinoid X receptor alpha	Homo sapiens	175-178
17699549-0	2007	Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro.	Vitamin D	51-60	fibroblast growth factor 23	Mus musculus	0-27
17607662-1	2007	BACKGROUND: The vitamin D system has been implicated in type 1 diabetes by epidemiological and immune intervention studies as well as by polymorphisms of the vitamin D binding protein (DBP) and CYP27B1 genes.	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	158-183
17716971-9	2007	Finally, we show that upon DNA damage, induction of VDR sensitizes the cells to vitamin D treatment.	Vitamin D	80-89	vitamin D receptor	Homo sapiens	52-55
17919258-4	2007	On the other hand, PARP activation modulates important inflammatory pathways, and PARP-1 activity can also be modulated by several endogenous factors such as various kinases, purines, vitamin D, thyroid hormones, polyamines, and estrogens, just to mention a few.	Vitamin D	184-193	poly (ADP-ribose) polymerase family, member 1	Mus musculus	82-88
17932346-0	2007	Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	67-70
17932346-0	2007	Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer.	Vitamin D	42-51	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	85-92
17932346-9	2007	Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	47-50
17976083-1	2007	Fibroblast growth factor-23 (FGF-23) is a circulating factor regulating phosphate and vitamin D homeostasis.	Vitamin D	86-95	fibroblast growth factor 23	Homo sapiens	0-27
17976083-1	2007	Fibroblast growth factor-23 (FGF-23) is a circulating factor regulating phosphate and vitamin D homeostasis.	Vitamin D	86-95	fibroblast growth factor 23	Homo sapiens	29-35
17976083-2	2007	Phosphate intake and an administration of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) increase circulating FGF-23 levels, and elevated FGF-23 prevents hyperphosphatemia and vitamin D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)(2)D level, comprising a feedback loop to maintain phosphate and vitamin D homeostasis.	Vitamin D	56-65	fibroblast growth factor 23	Homo sapiens	108-114
17976083-2	2007	Phosphate intake and an administration of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) increase circulating FGF-23 levels, and elevated FGF-23 prevents hyperphosphatemia and vitamin D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)(2)D level, comprising a feedback loop to maintain phosphate and vitamin D homeostasis.	Vitamin D	56-65	fibroblast growth factor 23	Homo sapiens	136-142
17976083-2	2007	Phosphate intake and an administration of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) increase circulating FGF-23 levels, and elevated FGF-23 prevents hyperphosphatemia and vitamin D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)(2)D level, comprising a feedback loop to maintain phosphate and vitamin D homeostasis.	Vitamin D	174-183	fibroblast growth factor 23	Homo sapiens	136-142
17976083-7	2007	FGF-23 may have a physiological role in preventing tissue damage such as ectopic calcifications, partly via suppressing the serum calcium x phosphate product by accelerating urinary phosphate excretion and suppressing vitamin D activation.	Vitamin D	218-227	fibroblast growth factor 23	Homo sapiens	0-6
17268418-1	2007	Vitamin D has been suggested to affect the balance between T helper (Th1) and (Th2) type cytokines by favouring Th2 domination.	Vitamin D	0-9	negative elongation factor complex member C/D	Homo sapiens	69-72
17710231-6	2007	Taken together, our findings provide what we believe to be the first evidence that loss-of-function mutations in human KL impair FGF23 bioactivity, underscoring the essential role of KL in FGF23-mediated phosphate and vitamin D homeostasis in humans.	Vitamin D	218-227	klotho	Homo sapiens	119-121
17710231-6	2007	Taken together, our findings provide what we believe to be the first evidence that loss-of-function mutations in human KL impair FGF23 bioactivity, underscoring the essential role of KL in FGF23-mediated phosphate and vitamin D homeostasis in humans.	Vitamin D	218-227	fibroblast growth factor 23	Homo sapiens	129-134
17609203-1	2007	Atrichia with papular lesions (APL) and hereditary vitamin D-resistant rickets have a similar congenital hair loss disorder caused by mutations in hairless (HR) and vitamin D receptor (VDR) genes, respectively.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	165-183
17609203-1	2007	Atrichia with papular lesions (APL) and hereditary vitamin D-resistant rickets have a similar congenital hair loss disorder caused by mutations in hairless (HR) and vitamin D receptor (VDR) genes, respectively.	Vitamin D	51-60	vitamin D receptor	Homo sapiens	185-188
17641030-5	2007	B cells expressed mRNAs for proteins involved in vitamin D activity, including 1 alpha-hydroxylase, 24-hydroxylase, and the vitamin D receptor, each of which was regulated by 1,25(OH)(2)D(3) and/or activation.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	124-142
17565270-3	2007	RECENT FINDINGS: Vitamin D-induced transcriptional repression of several negative vitamin D receptor target genes has been studied on a molecular level.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	82-100
17565270-5	2007	The vitamin D receptor, activated by vitamin D, does not directly bind to the negative vitamin D response elements, but instead associates with VDIR.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	4-22
17565270-7	2007	SUMMARY: Histone inactivation induced by histone deacetylase co-repressors appears to facilitate vitamin D-induced transcriptional repression via the vitamin D receptor.	Vitamin D	97-106	vitamin D receptor	Homo sapiens	150-168
17565270-8	2007	Following vitamin D binding, structural alteration of the DNA-unbound vitamin D receptor triggers transcriptional repression.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	70-88
17554146-7	2007	The vitamin D-deficient diet also improved survival in FGF23 null mice in association with normalization of 1,25(OH)(2)D and calcium levels and despite persistent hyperphosphatemia and vascular calcifications, indicating that excessive vitamin D activity can also have adverse effects in the presence of hyperphosphatemia and absence of FGF23.	Vitamin D	4-13	fibroblast growth factor 23	Mus musculus	55-60
17554146-7	2007	The vitamin D-deficient diet also improved survival in FGF23 null mice in association with normalization of 1,25(OH)(2)D and calcium levels and despite persistent hyperphosphatemia and vascular calcifications, indicating that excessive vitamin D activity can also have adverse effects in the presence of hyperphosphatemia and absence of FGF23.	Vitamin D	4-13	fibroblast growth factor 23	Mus musculus	337-342
17592215-2	2007	The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	45-63
17592215-2	2007	The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	65-68
17475215-0	2007	Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene.	Vitamin D	36-45	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	74-79
17475215-2	2007	Two vitamin D-responsive elements (VDREs) located immediately upstream of the CYP24 gene are primarily responsible for the induction.	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	78-83
17374707-1	2007	CONTEXT: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disease caused by mesenchymal tumors that secrete fibroblast growth factor-23 (FGF-23), a newly-described vitamin D and phosphate-regulating hormone.	Vitamin D	173-182	fibroblast growth factor 23	Homo sapiens	146-152
17507731-2	2007	More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	74-92
17507731-2	2007	More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism.	Vitamin D	25-34	vitamin D receptor	Homo sapiens	94-97
17408240-2	2007	The vitamin D-induced protein-protein interactions between VDR and fluorophore (Cy3 or Cy5)-labeled TIF2 or SRC-1 were successfully detected by using a new HCHO fixing method of the protein complex on microplates.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	59-62
22461213-5	2007	Polymorphisms of VDR and ERalphaloci appear genetic determinants of their corresponding hormonal treatment response such as vitamin D and estrogens.	Vitamin D	124-133	vitamin D receptor	Homo sapiens	17-20
17325131-1	2007	The vitamin D receptor (VDR) mediates the biological actions of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the active form of vitamin D, which regulates calcium homeostasis, immunity, cellular differentiation, and other physiological processes.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
17325131-4	2007	These vitamin D derivatives bind to VDR but do not stabilize an active cofactor conformation.	Vitamin D	6-15	vitamin D receptor	Homo sapiens	36-39
17325131-9	2007	We examined the expression of endogenous VDR target genes and the nuclear protein levels of VDR and cofactors in several cell lines, including cells derived from intestine, bone, and monocytes, and found that the vitamin D(3) derivatives act as cell type-selective VDR modulators.	Vitamin D	213-222	vitamin D receptor	Homo sapiens	41-44
17325131-9	2007	We examined the expression of endogenous VDR target genes and the nuclear protein levels of VDR and cofactors in several cell lines, including cells derived from intestine, bone, and monocytes, and found that the vitamin D(3) derivatives act as cell type-selective VDR modulators.	Vitamin D	213-222	vitamin D receptor	Homo sapiens	92-95
17325131-9	2007	We examined the expression of endogenous VDR target genes and the nuclear protein levels of VDR and cofactors in several cell lines, including cells derived from intestine, bone, and monocytes, and found that the vitamin D(3) derivatives act as cell type-selective VDR modulators.	Vitamin D	213-222	vitamin D receptor	Homo sapiens	92-95
16949543-1	2007	Vitamin D receptor (VDR) mediates a wide variety of vitamin D actions through transcriptional controls of target genes as a ligand-dependent transcription factor.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	0-18
16949543-1	2007	Vitamin D receptor (VDR) mediates a wide variety of vitamin D actions through transcriptional controls of target genes as a ligand-dependent transcription factor.	Vitamin D	52-61	vitamin D receptor	Homo sapiens	20-23
17224124-6	2007	Our findings validate the new model of CYP24A1, which can now be used to predict structural modifications for rational vitamin D drug design.	Vitamin D	119-128	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	39-46
17310066-6	2007	Here, we show transcriptional activation of the vitamin D-responsive 24-hydroxylase promoter by VDR in primary keratinocytes that is independent of the 1,25(OH)2D3 ligand.	Vitamin D	48-57	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	96-99
17506310-0	2007	[Regulation of phosphorus-vitamin D metabolism by FGF23].	Vitamin D	26-35	fibroblast growth factor 23	Homo sapiens	50-55
17082781-1	2007	It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR).	Vitamin D	53-62	vitamin D receptor	Homo sapiens	202-220
17082781-1	2007	It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR).	Vitamin D	53-62	vitamin D receptor	Homo sapiens	222-225
17332731-0	2007	Klotho: an antiaging protein involved in mineral and vitamin D metabolism.	Vitamin D	53-62	klotho	Homo sapiens	0-6
17332731-6	2007	The two last functions have propelled klotho to the group of key factors regulating mineral and vitamin D metabolism, and have also stimulated the interest of the nephrology community.	Vitamin D	96-105	klotho	Homo sapiens	38-44
17218095-1	2007	Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D interacting complex)/Mediator complex.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	90-93
17218095-1	2007	Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D interacting complex)/Mediator complex.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	156-159
17223545-4	2007	In the studies reported here, we utilized the above techniques to identify key enhancer regions that mediate the actions of vitamin D on the calcium ion channel gene TRPV6, the catabolic bone calcium-mobilizing factor gene RankL and the bone anabolic Wnt signaling pathway co-receptor gene LRP5.	Vitamin D	124-133	transient receptor potential cation channel subfamily V member 6	Homo sapiens	166-171
17223545-4	2007	In the studies reported here, we utilized the above techniques to identify key enhancer regions that mediate the actions of vitamin D on the calcium ion channel gene TRPV6, the catabolic bone calcium-mobilizing factor gene RankL and the bone anabolic Wnt signaling pathway co-receptor gene LRP5.	Vitamin D	124-133	TNF superfamily member 11	Homo sapiens	223-228
17388667-2	2007	Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	197-215
17388667-2	2007	Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	217-220
17388667-4	2007	Few studies have explored the joint association of circulating vitamin D levels with VDR polymorphisms.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	85-88
17388667-16	2007	Moreover, vitamin D status, measured by 25(OH)D in plasma, interacts with the VDR FokI polymorphism and modifies prostate cancer risk.	Vitamin D	10-19	vitamin D receptor	Homo sapiens	78-81
17347552-4	2007	Vitamin D-binding protein (DBP) binds, transports and activates vitamin D, which plays a major role in calcium homeostasis and bone turnover.	Vitamin D	64-73	GC vitamin D binding protein	Homo sapiens	0-25
17244528-4	2007	Various Ca(2+) mobilizing agents (vitamin D(3) compounds, ionomycin, ATP, and thapsigargin) inhibit the activity of mammalian target of rapamycin, a negative regulator of macroautophagy, and induce massive accumulation of autophagosomes in a Beclin 1- and Atg7-dependent manner.	Vitamin D	34-43	beclin 1	Homo sapiens	242-250
17121851-1	2007	Vitamin D receptor (VDR) is a ligand-dependent transcription factor that mediates vitamin D(3)-induced gene expression.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	0-18
17121851-1	2007	Vitamin D receptor (VDR) is a ligand-dependent transcription factor that mediates vitamin D(3)-induced gene expression.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	20-23
17121851-10	2007	Existence of the non-classical VDR pathway was suggested by a requirement of both c-Jun and VDR in stress-induced VDR activity and further demonstrated by VDR inhibiting c-Jun-dependent cell death independent of its classical transcriptional activity and independent of vitamin D(3).	Vitamin D	270-279	vitamin D receptor	Homo sapiens	31-34
17121851-11	2007	c-Jun is also required for vitamin D(3)-induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins.	Vitamin D	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
17121851-11	2007	c-Jun is also required for vitamin D(3)-induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	58-61
17121851-11	2007	c-Jun is also required for vitamin D(3)-induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins.	Vitamin D	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-154
17121851-11	2007	c-Jun is also required for vitamin D(3)-induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	159-162
17029768-3	2007	We therefore investigated basal and Vitamin D-regulated expression and activity of the synthesizing (CYP27B1) and metabolizing (CYP24A1) hydroxylase in three cell lines derived from the colon, and compared this to cells from the prostate and mammary gland.	Vitamin D	36-45	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	128-135
17914260-2	2007	Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of several genes involved in CKD and PD disease mechanisms.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	85-88
18067661-1	2007	INTRODUCTION: The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest.	Vitamin D	33-42	vitamin D receptor	Homo sapiens	53-56
17106204-0	2007	Vitamin D receptor polymorphisms in hypocalcemic vitamin D-resistant rickets carriers.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	0-18
17106204-9	2007	CONCLUSIONS: Our findings showed that the apparently healthy HVDRR carriers present a different distribution of BsmI and TaqI VDR polymorphisms than their controls, suggesting that further investigation of the HVDRR carrier population may elucidate the implication of VDR alleles in VDR function and the vitamin D endocrine system.	Vitamin D	304-313	vitamin D receptor	Homo sapiens	62-65
17687191-1	2007	BACKGROUND: The vitamin D receptor (VDR) is involved in the regulation of renin expression and vitamin D analogs down-regulated renin mRNA expression in As4.1 cells.	Vitamin D	16-25	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	36-39
17156732-5	2006	In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	3-12	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	71-78
17156732-5	2006	In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	3-12	vitamin D receptor	Homo sapiens	202-220
17156732-5	2006	In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	3-12	vitamin D receptor	Homo sapiens	222-225
17156732-5	2006	In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	44-53	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	71-78
17156732-5	2006	In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	44-53	vitamin D receptor	Homo sapiens	202-220
17156732-5	2006	In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR).	Vitamin D	44-53	vitamin D receptor	Homo sapiens	222-225
17002582-0	2006	Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women.	Vitamin D	83-92	transient receptor potential cation channel subfamily V member 6	Homo sapiens	16-21
17002582-4	2006	We aimed to characterize TRPV6 expression in human intestine including defining relationships to the vitamin D endocrine system.	Vitamin D	101-110	transient receptor potential cation channel subfamily V member 6	Homo sapiens	25-30
17002582-7	2006	TRPV6 expression was related in 33 subjects to other transcripts involved in calcium absorption including the vitamin D receptor (VDR) and to blood vitamin D metabolites including 1,25-dihydroxyvitamin D [1,25(OH)(2)D].	Vitamin D	110-119	transient receptor potential cation channel subfamily V member 6	Homo sapiens	0-5
17002582-16	2006	CONCLUSIONS: Duodenal TRPV6 expression is vitamin D dependent in men, but not in older women, where expression of TRPV6 and VDR are both reduced.	Vitamin D	42-51	transient receptor potential cation channel subfamily V member 6	Homo sapiens	22-27
17002582-16	2006	CONCLUSIONS: Duodenal TRPV6 expression is vitamin D dependent in men, but not in older women, where expression of TRPV6 and VDR are both reduced.	Vitamin D	42-51	transient receptor potential cation channel subfamily V member 6	Homo sapiens	114-119
17002582-16	2006	CONCLUSIONS: Duodenal TRPV6 expression is vitamin D dependent in men, but not in older women, where expression of TRPV6 and VDR are both reduced.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	124-127
16708384-0	2006	CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer.	Vitamin D	63-72	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-5
16936639-3	2006	The presence of 9-cis-RA increases induction of cyp24 transcripts and differentiation of colon cancer cells by vitamin D, confers significant agonistic activity to a VDR ligand with very low agonistic activity and can even restore transcriptional activity of an AF-2 mutant VDR that causes hereditary rickets.	Vitamin D	111-120	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	48-53
16936639-4	2006	This study shows that, in VDR/RXR heterodimers, allosteric communication triggered by the RXR ligand has a previously unrecognized role in vitamin D signalling, with important physiological and therapeutic implications.	Vitamin D	139-148	vitamin D receptor	Homo sapiens	26-29
16936639-4	2006	This study shows that, in VDR/RXR heterodimers, allosteric communication triggered by the RXR ligand has a previously unrecognized role in vitamin D signalling, with important physiological and therapeutic implications.	Vitamin D	139-148	retinoid X receptor alpha	Homo sapiens	30-33
16936639-4	2006	This study shows that, in VDR/RXR heterodimers, allosteric communication triggered by the RXR ligand has a previously unrecognized role in vitamin D signalling, with important physiological and therapeutic implications.	Vitamin D	139-148	retinoid X receptor alpha	Homo sapiens	90-93
16362385-6	2006	We thus conclude that ER and VDR genes may contribute to lumbar spondylosis in a distinct manner: estrogen sensitivity influences the severity in the early phase after menopause while vitamin D plays an important role at older ages when the contribution of estrogen loss is weaker.	Vitamin D	184-193	vitamin D receptor	Homo sapiens	29-32
16806146-2	2006	BACKGROUND: Vitamin D receptor (VDR) mediates the effects of vitamin D.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	12-30
16806146-2	2006	BACKGROUND: Vitamin D receptor (VDR) mediates the effects of vitamin D.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	32-35
16884396-5	2006	The interactions of FGF-23 with phosphate, parathyroid hormone and vitamin D are discussed in detail.	Vitamin D	67-76	fibroblast growth factor 23	Homo sapiens	20-26
16720650-0	2006	C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status.	Vitamin D	84-93	complement C3	Homo sapiens	0-3
16457885-4	2006	Taken together, inhibition of CYP24 might open a new paradigm for therapy using Vitamin D compounds.	Vitamin D	80-89	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-35
16886676-1	2006	BACKGROUND: Levels of active vitamin D (VD) are controlled by synthesis via CYP27B1 and self-induced metabolism by CYP24A1.	Vitamin D	29-38	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	115-122
16886676-8	2006	CONCLUSION: Selective CYP24A1 inhibitors could herald a new era for vitamin D research, as well as for therapeutic application.	Vitamin D	68-77	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	22-29
16709624-1	2006	BACKGROUND: Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D.	Vitamin D	25-34	GC vitamin D binding protein	Homo sapiens	12-23
16957418-1	2006	The active form of vitamin D, 1,25-dihydroxyvitamin D3, is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors, and exerts a number of diverse biological functions.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	99-117
16957418-1	2006	The active form of vitamin D, 1,25-dihydroxyvitamin D3, is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors, and exerts a number of diverse biological functions.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	119-122
16362534-8	2006	Finally, we observed that treatment with 10(-6) M of the pro-hormone 25 VD for 24 h resulted in a significant increase in TRPV6 expression in Caco-2 cells, which is consistent with the presence of 1alpha-hydroxylase (CYP27B1) expression in Caco-2 cells and a possible autocrine vitamin D signaling pathway in colon cells.	Vitamin D	278-287	transient receptor potential cation channel subfamily V member 6	Homo sapiens	122-127
16362534-9	2006	CONCLUSIONS: 1,25 dihydroxyvitamin D regulates TRPV6 expression by a process that requires new mRNA and protein synthesis and the point of regulation lies likely at the transcriptional level especially since vitamin D did not increase the half life of TRPV6 mRNA.	Vitamin D	27-36	transient receptor potential cation channel subfamily V member 6	Homo sapiens	47-52
16476762-2	2006	Oestrogens, androgens, corticosteroids, parathyroid hormone (PTH), vitamin D, and several cytokines exert their effects on bone modulating the OPG/RANKL system.	Vitamin D	67-76	TNF superfamily member 11	Homo sapiens	147-152
16596260-1	2006	The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	134-152
16596260-1	2006	The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively.	Vitamin D	63-72	vitamin D receptor	Homo sapiens	154-157
16365879-0	2006	UVB-induced production of 1,25-dihydroxyvitamin D3 and vitamin D activity in human keratinocytes pretreated with a sterol delta7-reductase inhibitor.	Vitamin D	40-49	7-dehydrocholesterol reductase	Homo sapiens	115-138
16365879-3	2006	In addition, epidermal keratinocytes contain the vitamin D receptor (VDR) and possess 25-hydroxylase and 1alpha-hydroxylase activity indicating that all components of the vitamin D system are present.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	69-72
16365879-6	2006	Transfection experiments with a vitamin D response element containing construct confirmed VDR-dependent gene activation.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	90-93
16618780-4	2006	We also identified a putative positive vitamin D response element within the MKP5 promoter that associated with the vitamin D receptor following 1,25D treatment.	Vitamin D	39-48	vitamin D receptor	Homo sapiens	116-134
16436465-0	2006	Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.	Vitamin D	77-86	fibroblast growth factor 23	Mus musculus	34-61
16436465-3	2006	Our results indicate a novel role of Fgf-23 in developing premature aging-like features through regulating vitamin D homeostasis.	Vitamin D	107-116	fibroblast growth factor 23	Mus musculus	37-43
16549446-6	2006	In support of this suggestion, both 1alpha,25(OH)2D3 and 25(OH)D3 transactivated VDR in HMEC cultures, as measured by induction of a vitamin D responsive reporter gene and upregulation of CYP24, an endogenous VDR target gene.	Vitamin D	133-142	vitamin D receptor	Homo sapiens	81-84
16357103-0	2006	An essential role of the CAAT/enhancer binding protein-alpha in the vitamin D-induced expression of the human steroid/bile acid-sulfotransferase (SULT2A1).	Vitamin D	68-77	sulfotransferase family 2A member 1	Homo sapiens	146-153
16357103-3	2006	1alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] induces SULT2A1 gene transcription after the recruitment of VDR to the vitamin D-responsive chromatin region of SULT2A1.	Vitamin D	19-28	sulfotransferase family 2A member 1	Homo sapiens	53-60
16357103-3	2006	1alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] induces SULT2A1 gene transcription after the recruitment of VDR to the vitamin D-responsive chromatin region of SULT2A1.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	105-108
16357103-3	2006	1alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] induces SULT2A1 gene transcription after the recruitment of VDR to the vitamin D-responsive chromatin region of SULT2A1.	Vitamin D	19-28	sulfotransferase family 2A member 1	Homo sapiens	157-164
16357103-5	2006	This element combines a VDR/retinoid X receptor-alpha-binding site [vitamin D response element (VDRE)], which is an imperfect inverted repeat 2 of AGCTCA, and a CAAT/enhancer binding protein (C/EBP)-binding site located 9 bp downstream to VDRE.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	24-27
16357103-5	2006	This element combines a VDR/retinoid X receptor-alpha-binding site [vitamin D response element (VDRE)], which is an imperfect inverted repeat 2 of AGCTCA, and a CAAT/enhancer binding protein (C/EBP)-binding site located 9 bp downstream to VDRE.	Vitamin D	68-77	retinoid X receptor alpha	Homo sapiens	28-53
16314444-5	2006	Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC.	Vitamin D	176-185	vitamin D receptor	Homo sapiens	14-17
16314444-5	2006	Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC.	Vitamin D	193-202	vitamin D receptor	Homo sapiens	14-17
16213141-3	2006	Diamino 5 and 6 as well as monoamino 3, 4, 30, and 31 vitamin D(3) derivatives have shown poor binding to VDR compared with 1alpha,25-dihydroxyvitamin D(3).	Vitamin D	54-63	vitamin D receptor	Homo sapiens	106-109
16946620-1	2006	Mutations in vitamin D receptor (VDR) cause hereditary vitamin D resistant rickets (HVDRR).	Vitamin D	13-22	vitamin D receptor	Homo sapiens	33-36
16424674-1	2006	BACKGROUND/AIMS: Hypocalcemic vitamin D-resistant rickets (HVDRR) is a rare monogenic autosomal recessive disorder associated with mutations in the gene of the vitamin D receptor (VDR), the mediator of 1,25(OH)2D3 action.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	160-178
16424674-1	2006	BACKGROUND/AIMS: Hypocalcemic vitamin D-resistant rickets (HVDRR) is a rare monogenic autosomal recessive disorder associated with mutations in the gene of the vitamin D receptor (VDR), the mediator of 1,25(OH)2D3 action.	Vitamin D	30-39	vitamin D receptor	Homo sapiens	60-63
16355284-2	2006	Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.	Vitamin D	83-92	vitamin D receptor	Homo sapiens	45-48
16355284-10	2006	RESULTS: Compared with carriers of the G allele, homozygotes for the rare Cdx-2 A polymorphism (n = 136) had less bone loss (-0.5 +/- 1.2 versus -0.7 +/- 1.0%/year [SD]; p = 0.01) and lower PTH (3.0 +/- 1.6 versus 3.4 +/- 2.0 pM; p = 0.03) despite similar vitamin D status.	Vitamin D	256-265	caudal type homeobox 2	Homo sapiens	74-79
16369891-9	2006	The abnormal vitamin D mechanism in response to hypophosphatemia in MAS patients also proved recently to be caused by the increased circulating FGF-23 levels.	Vitamin D	13-22	fibroblast growth factor 23	Homo sapiens	144-150
16123154-1	2005	Fibroblast growth factor-23 (FGF-23) is a novel circulating peptide that regulates phosphorus (Pi) and vitamin D metabolism, but the mechanisms by which circulating FGF-23 itself is regulated are unknown.	Vitamin D	103-112	fibroblast growth factor 23	Mus musculus	0-27
16123154-1	2005	Fibroblast growth factor-23 (FGF-23) is a novel circulating peptide that regulates phosphorus (Pi) and vitamin D metabolism, but the mechanisms by which circulating FGF-23 itself is regulated are unknown.	Vitamin D	103-112	fibroblast growth factor 23	Mus musculus	29-35
15998839-0	2005	Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism.	Vitamin D	73-82	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-18
15998839-0	2005	Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism.	Vitamin D	73-82	fibroblast growth factor 23	Mus musculus	31-36
16302727-1	2005	The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)).	Vitamin D	55-64	GC vitamin D binding protein	Homo sapiens	84-95
15905882-0	2005	Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.	Vitamin D	0-9	beclin 1	Homo sapiens	64-72
16164627-11	2005	Transfection studies revealed that 1,25(OH)(2)D(3) stimulated HGF gene promoter activity, which was dependent on the presence of vitamin D response element (VDRE).	Vitamin D	129-138	hepatocyte growth factor	Rattus norvegicus	62-65
16164627-16	2005	This action of vitamin D is mediated, at least in part, by up-regulating antifibrotic HGF gene expression in renal interstitial fibroblasts.	Vitamin D	15-24	hepatocyte growth factor	Rattus norvegicus	86-89
16279693-0	2005	[Regulatory effect of FGF23 on phosphate and vitamin D metabolism].	Vitamin D	45-54	fibroblast growth factor 23	Homo sapiens	22-27
16020493-1	2005	BACKGROUND: Measurement of 25-hydroxyvitamin D2 and D3 (25-OH D2 and D3) is essential for investigating vitamin D deficiency.	Vitamin D	37-46	immunoglobulin heavy diversity 2-15	Homo sapiens	62-71
16059639-16	2005	CONCLUSION: Our study provides new insights into the mechanisms involved in the enhancement of VDR function by both phosphorylation and hexafluoro analogs and forms a basis for future study of vitamin D analogs or specifically designed kinase activity mediators as potential therapy for the treatment of selected patients with HVDRR.	Vitamin D	193-202	vitamin D receptor	Homo sapiens	95-98
15890672-2	2005	The most bioactive form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] elicits its effects by binding to the vitamin D receptor (VDR) and regulating the transcription of target genes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	116-134
15890672-2	2005	The most bioactive form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] elicits its effects by binding to the vitamin D receptor (VDR) and regulating the transcription of target genes.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	136-139
15992766-1	2005	The vitamin D receptor (VDR) mediates the effects of 1,25(OH)(2)D(3), the active form of vitamin D.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
15885032-1	2005	FGF23 (fibroblast growth factor 23) is a novel phosphaturic factor that influences vitamin D metabolism and renal re-absorption of Pi.	Vitamin D	83-92	fibroblast growth factor 23	Mus musculus	0-5
15885032-1	2005	FGF23 (fibroblast growth factor 23) is a novel phosphaturic factor that influences vitamin D metabolism and renal re-absorption of Pi.	Vitamin D	83-92	fibroblast growth factor 23	Mus musculus	7-34
15868280-1	2005	The major transporter of vitamin D metabolites in the circulation is the multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, vitamin D-binding protein, or DBP.	Vitamin D	25-34	GC vitamin D binding protein	Homo sapiens	161-186
15985530-5	2005	The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR).	Vitamin D	39-48	vitamin D receptor	Homo sapiens	116-134
15985530-5	2005	The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR).	Vitamin D	39-48	vitamin D receptor	Homo sapiens	67-70
15869926-0	2005	Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations.	Vitamin D	37-46	fibroblast growth factor 23	Mus musculus	82-87
15869926-1	2005	Fibroblast growth factor-23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism.	Vitamin D	103-112	fibroblast growth factor 23	Mus musculus	0-27
15869926-1	2005	Fibroblast growth factor-23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism.	Vitamin D	103-112	fibroblast growth factor 23	Mus musculus	29-34
15863037-4	2005	FGF23 circulates in the bloodstream, and animal models demonstrate that FGF23 controls phosphate and Vitamin D homeostasis through the regulation of specific renal proteins.	Vitamin D	101-110	fibroblast growth factor 23	Homo sapiens	72-77
15749088-3	2005	However, it is now established that FGF23 can be a humoral messenger and an important regulator of phosphate homeostasis and vitamin D metabolism.	Vitamin D	125-134	fibroblast growth factor 23	Homo sapiens	36-41
15639181-1	2005	Vitamin D (calcitriol) is a nuclear transcription regulator acting via a nuclear hormone receptor (VDR).	Vitamin D	0-9	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	99-102
15709781-1	2005	The vitamin D receptor (VDR) is a ligand-responsive transcription factor that forms active, heterodimeric complexes with the 9-cis retinoic acid receptor (RXR) on vitamin D response elements (VDREs).	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
15709781-1	2005	The vitamin D receptor (VDR) is a ligand-responsive transcription factor that forms active, heterodimeric complexes with the 9-cis retinoic acid receptor (RXR) on vitamin D response elements (VDREs).	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	155-158
15862966-0	2005	A20 gene expression is regulated by TNF, Vitamin D and androgen in prostate cancer cells.	Vitamin D	41-50	immunoglobulin kappa variable 1-27	Homo sapiens	0-3
15862966-2	2005	We studied A20 gene expression in the Vitamin D- and TNF-sensitive LNCaP cell line and in the Vitamin D- and TNF-resistant PC-3 cell line.	Vitamin D	38-47	immunoglobulin kappa variable 1-27	Homo sapiens	11-14
15862966-6	2005	We conclude that A20 may be involved in the regulation of cell proliferation by TNF, Vitamin D, and androgen in prostate cancer.	Vitamin D	85-94	immunoglobulin kappa variable 1-27	Homo sapiens	17-20
15664452-1	2005	1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of Vitamin D, mediates gene transcription through the Vitamin D receptor (VDR), a nuclear receptor expressed in multiple normal and transformed cell types.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	116-134
15664452-1	2005	1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of Vitamin D, mediates gene transcription through the Vitamin D receptor (VDR), a nuclear receptor expressed in multiple normal and transformed cell types.	Vitamin D	65-74	vitamin D receptor	Homo sapiens	136-139
15574355-12	2005	Surprisingly, more than 70 % of the vitamin D metabolites observed in a living body were found to be the products formed by the activities of CYP27A1, CYP27B1 and CYP24A1.	Vitamin D	36-45	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	163-170
15574355-13	2005	The species-based difference was also observed in the metabolism of vitamin D analogs by CYP24A1, suggesting that the recombinant system for human CYP24A1 may be of great use for the prediction of the metabolism of vitamin D analogs in humans.	Vitamin D	68-77	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-96
15574355-13	2005	The species-based difference was also observed in the metabolism of vitamin D analogs by CYP24A1, suggesting that the recombinant system for human CYP24A1 may be of great use for the prediction of the metabolism of vitamin D analogs in humans.	Vitamin D	68-77	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	147-154
15574355-13	2005	The species-based difference was also observed in the metabolism of vitamin D analogs by CYP24A1, suggesting that the recombinant system for human CYP24A1 may be of great use for the prediction of the metabolism of vitamin D analogs in humans.	Vitamin D	215-224	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-96
15589699-9	2005	The widespread distribution of 1alpha-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain.	Vitamin D	70-79	vitamin D receptor	Homo sapiens	52-55
15630458-1	2005	Vitamin D controls calcium homeostasis and the development and maintenance of bones through vitamin D receptor activation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	92-110
15630458-5	2005	CYP24 is a mitochondrial enzyme responsible for inactivating vitamin D metabolites.	Vitamin D	61-70	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-5
15630458-10	2005	We demonstrated that PXR binds to and transactivates the 2 proximal vitamin D-responsive elements of the human CYP24 promoter.	Vitamin D	68-77	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	111-116
15570056-12	2004	These cells have normal levels of VDR and normal binding of VDR to vitamin D response elements.	Vitamin D	67-76	vitamin D receptor	Homo sapiens	60-63
15544953-4	2004	A five-step inactivation pathway from 1alpha,25-(OH)(2)D(3) to calcitroic acid is attributed to a single multifunctional CYP, CYP24A1, which is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-(OH)(2)D(3).	Vitamin D	173-182	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	126-133
15522514-7	2004	The present study suggests that HSDs may catalyze the C-3 epimerization of vitamin D compounds and modulate their concentrations and biological activities in animals and humans.	Vitamin D	75-84	complement C3	Homo sapiens	54-57
15337762-1	2004	The PHEX gene encodes an endopeptidase expressed in osteoblasts that inactivates an uncharacterized peptide hormone, phosphatonin, which suppresses bone mineralization as well as renal phosphate reabsorption and vitamin D bioactivation.	Vitamin D	212-221	phosphate regulating endopeptidase homolog, X-linked	Rattus norvegicus	4-8
15337762-2	2004	We demonstrate that 1alpha-25-dihydroxyvitamin D (1,25(OH)2D3), the, active renal vitamin D metabolite, decreases PHEX mRNA in the rat osteoblastic cell line, UMR-106, as well as in mouse calvaria.	Vitamin D	39-48	phosphate regulating endopeptidase homolog, X-linked	Rattus norvegicus	114-118
15284207-7	2004	Our findings strongly support the novel concept that high circulating levels of FGF23 are associated with profound disturbances in the regulation of phosphate and vitamin D metabolism as well as calcium homeostasis and that elevated PTH levels likely also contribute to the renal phosphate wasting associated with these disorders.	Vitamin D	163-172	fibroblast growth factor 23	Homo sapiens	80-85
15297458-1	2004	An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	220-238
15297458-1	2004	An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	78-81
15297458-8	2004	Furthermore, findings suggest that the repressive effects of vitamin D on hPTH gene transcription may involve displacement of NF-Y binding to the proximal site by the VDR heterodimer, which subsequently attenuates synergistic transactivation.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	167-170
15165995-6	2004	Similar results were observed in VDR knockout mice after their blood ionized calcium levels and rachitic bone phenotype were normalized by dietary means, indicating that vitamin D regulation of NaSi-1 expression and sulfate metabolism is independent of its role in calcium metabolism.	Vitamin D	170-179	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	33-36
15252846-12	2004	The risk associated with VDR genotype seems to depend upon the level of dietary calcium and vitamin D and tumor site.	Vitamin D	92-101	vitamin D receptor	Homo sapiens	25-28
15352170-2	2004	A VDR ablated transgenic animal model (VDDRII, vitamin D-dependent rickets type II) has been developed and the animals typically have various diseases including, hypocalcemia, hyperparathyroidism, rickets, osteomalacia, and alopecia.	Vitamin D	47-56	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	2-5
15322208-8	2004	However, VDR-deficient mice failed to develop experimental allergic asthma, suggesting an important role for the vitamin D endocrine system in the generation of Th2-driven inflammation in the lung.	Vitamin D	113-122	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	9-12
15178742-2	2004	VDR is a nuclear receptor whose ligand, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] is generated after metabolic activation of vitamin D by specific vitamin D hydroxylases.	Vitamin D	54-63	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
15218361-7	2004	Electrophoretic mobility shift assays using a putative vitamin D response element within this region of the EGFR promoter demonstrated specific VDR binding.	Vitamin D	55-64	vitamin D receptor	Homo sapiens	144-147
15066998-8	2004	Also, inhibition of tuberin expression during stimulation of monocytic differentiation with vitamin D(3) and TGF-beta1 significantly impaired myeloid cell growth inhibition and differentiation.	Vitamin D	92-101	TSC complex subunit 2	Homo sapiens	20-27
15077124-9	2004	New vitamin D analogs that exert little calcemic side effects, their precursors, or inhibitors of 24-OHase may offer a new approach for the prevention or therapy of BCCs.	Vitamin D	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	98-106
15104566-1	2004	OBJECTIVE: Vitamin D modulates the immune system by suppressing the proliferation of activated T cells, with its actions being directed through the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	148-166
15104566-1	2004	OBJECTIVE: Vitamin D modulates the immune system by suppressing the proliferation of activated T cells, with its actions being directed through the vitamin D receptor (VDR).	Vitamin D	11-20	vitamin D receptor	Homo sapiens	168-171
15225744-7	2004	Based on these results, the enzyme responsible for the C-3 epimerization of Vitamin D3 are thought to be different from already-known cytochrome P450-related Vitamin D metabolic enzymes and HSE.	Vitamin D	76-85	complement C3	Homo sapiens	55-58
15225750-1	2004	To clarify the structure-function relationship (SFR) of vitamin D analogs in terms of their interaction with the vitamin D receptor (VDR), we have proposed a new approach, two-dimensional alanine scanning mutational analysis (2D-ASMA).	Vitamin D	56-65	vitamin D receptor	Homo sapiens	113-131
15225750-1	2004	To clarify the structure-function relationship (SFR) of vitamin D analogs in terms of their interaction with the vitamin D receptor (VDR), we have proposed a new approach, two-dimensional alanine scanning mutational analysis (2D-ASMA).	Vitamin D	56-65	vitamin D receptor	Homo sapiens	133-136
15225784-7	2004	Both DRIP205 and SRC-3 potentiated Vitamin D-induced transcription in proliferating cells, but during differentiation, DRIP205 was no longer effective.	Vitamin D	35-44	mediator complex subunit 1	Homo sapiens	5-12
15225792-0	2004	Duodenal expression of the epithelial calcium transporter gene TRPV6: is there evidence for Vitamin D-dependence in humans?	Vitamin D	92-101	transient receptor potential cation channel subfamily V member 6	Homo sapiens	63-68
15225798-3	2004	Here, we show the direct action of Vitamin D by transplanting the bone of the Vitamin D receptor null mutant mice (VDR-/-) to the wild-type mouse.	Vitamin D	35-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	78-96
15225798-3	2004	Here, we show the direct action of Vitamin D by transplanting the bone of the Vitamin D receptor null mutant mice (VDR-/-) to the wild-type mouse.	Vitamin D	35-44	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	115-118
15225812-0	2004	Does Vitamin D play a role on Msx1 homeoprotein expression involving an endogenous antisense mRNA?	Vitamin D	5-14	msh homeobox 1	Mus musculus	30-34
15225812-3	2004	Most of Msx1 target organs are also known for their sensitivity to Vitamin D: such as bone, tooth germ, and hair follicle.	Vitamin D	67-76	msh homeobox 1	Mus musculus	8-12
15225812-5	2004	This study aims to analyze the potential relationships between Vitamin D and Msx1 through: (1) comparative analysis of Vitamin D receptor (VDR) and Msx1 protein expression, (2) investigation of Msx1 expression in VDR null mutant mice, and (3) study of Msx1 overexpression impact on osteocalcin VDR expression in immortalized MO6-G3 odontoblasts.	Vitamin D	63-72	msh homeobox 1	Mus musculus	77-81
15225812-6	2004	Results show the existence of cross-talks between Vitamin D and Msx1 regulation pathways.	Vitamin D	50-59	msh homeobox 1	Mus musculus	64-68
15225812-9	2004	In Vitamin D null mutants, the study of the natural Msx1 antisense transcript which has been recently described should be informative.	Vitamin D	3-12	msh homeobox 1	Mus musculus	52-56
15255308-4	2004	Additional susceptibility is conferred by genomic variants of the vitamin D system (vitamin D receptor and CYP1 alpha hydroxylase).	Vitamin D	66-75	vitamin D receptor	Homo sapiens	84-102
15055995-4	2004	Here, we report the crystal structures of VDR ligand binding domain bound to two vitamin D agonists of therapeutical interest, calcipotriol and seocalcitol, which are characterized by their side chain modifications.	Vitamin D	81-90	vitamin D receptor	Homo sapiens	42-45
15165715-0	2004	The role of adrenomedullin and its receptor system in cardiovascular calcification of rat induced by Vitamin D(3) plus nicotine.	Vitamin D	101-110	adrenomedullin	Rattus norvegicus	12-26
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	53-71
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	73-76
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	109-112
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	retinoid X receptor alpha	Homo sapiens	130-149
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	retinoid X receptor alpha	Homo sapiens	151-154
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	109-112
15083599-2	2004	The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription.	Vitamin D	35-44	retinoid X receptor alpha	Homo sapiens	173-176
15147236-5	2004	VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes.	Vitamin D	32-41	vitamin D receptor	Homo sapiens	0-3
15147236-5	2004	VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes.	Vitamin D	32-41	retinoid X receptor alpha	Homo sapiens	132-151
15147236-5	2004	VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes.	Vitamin D	32-41	retinoid X receptor alpha	Homo sapiens	153-156
15147236-5	2004	VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes.	Vitamin D	195-204	vitamin D receptor	Homo sapiens	0-3
15147236-5	2004	VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes.	Vitamin D	195-204	retinoid X receptor alpha	Homo sapiens	132-151
15147236-5	2004	VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes.	Vitamin D	195-204	retinoid X receptor alpha	Homo sapiens	153-156
14966565-0	2004	Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.	Vitamin D	98-107	fibroblast growth factor 23	Mus musculus	21-26
14966565-0	2004	Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.	Vitamin D	98-107	fibroblast growth factor 23	Mus musculus	75-80
14966565-8	2004	These phenotypes could not be explained by currently known regulators of mineral homeostasis, indicating that FGF23 is essential for normal phosphate and vitamin D metabolism.	Vitamin D	154-163	fibroblast growth factor 23	Mus musculus	110-115
15504568-8	2004	Vitamin D itself induce the formation of osteoclasts by increasing the expression of RANKL on marrow stromal cells.	Vitamin D	0-9	TNF superfamily member 11	Homo sapiens	85-90
14525957-4	2004	In both vitamin D response element activation and mammalian two-hybrid assays, we found that VDR-S278V is activated by 1alpha,25(OH)2D3 but not by LCA, whereas VDR-S237M can respond to LCA but not to 1alpha,25(OH)2D3.	Vitamin D	8-17	vitamin D receptor	Homo sapiens	93-96
14507914-3	2003	Potential vitamin D response elements were identified within promoter regions of human and mouse relB genes.	Vitamin D	10-19	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	97-101
14507914-6	2003	The inhibition was abolished by mutagenesis of the putative vitamin D response elements and was enhanced by overexpression of VDR.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	126-129
14676077-3	2003	Atrichia with papules also occurs in the clinical setting of vitamin D-dependent rickets type IIA (VDDR IIA; OMIM 277440), resulting from mutations in the vitamin D receptor gene on chromosome 12q12-q14.	Vitamin D	61-70	vitamin D receptor	Homo sapiens	155-173
14698202-1	2003	A modified yeast one-hybrid screen was used to isolate proteins capable of interacting with the Vitamin D receptor (VDR) heterodimer complex while driving expression from a repressor Vitamin D response element (VDRE).	Vitamin D	96-105	vitamin D receptor	Homo sapiens	116-119
14500760-2	2003	The vitamin D receptor (VDR) is required for all known biologic effects of vitamin D.	Vitamin D	4-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	24-27
14528024-0	2003	Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system.	Vitamin D	117-126	klotho	Homo sapiens	0-6
14528024-9	2003	These observations suggest that klotho may participate in a negative regulatory circuit of the vitamin D endocrine system, through the regulation of 1alpha-hydroxylase gene expression.	Vitamin D	95-104	klotho	Mus musculus	32-38
14572874-3	2003	This may be interpreted to indicate a close relationship between VDR gene polymorphism and the immunological action, because vitamin D activates monocytes, stimulates cell-mediated immunity, and suppresses lymphocyte proliferation.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	65-68
14597850-1	2003	BACKGROUND: There are no studies that relate BsmI polymorphism of the vitamin D receptor (VDR) gene and with vitamin D to blood pressure (BP).	Vitamin D	70-79	vitamin D receptor	Homo sapiens	90-93
12843209-0	2003	Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor.	Vitamin D	45-54	vitamin D receptor	Homo sapiens	114-132
12972373-4	2003	Despite the distinct effects on Vitamin D(3) metabolism in the GH group, there were only moderate effects on the intestine, i.e. at 20 weeks of age there was a significant increase of 14.4 and 5.6% in fractional absorption of Ca and phosphate (Pi), respectively, compared to the control group.	Vitamin D	32-41	somatotropin	Canis lupus familiaris	63-65
12897203-3	2003	Ahsg-deficient mice are phenotypically normal, but develop severe calcification of various organs on a mineral and vitamin D-rich diet and on a normal diet when the deficiency is combined with a DBA/2 genetic background.	Vitamin D	115-124	alpha-2-HS-glycoprotein	Mus musculus	0-4
12914530-0	2003	Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase- polymerase chain reaction.	Vitamin D	31-40	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	74-79
12951895-14	2003	Vitamin D caused a concentration-dependent decrease in IFN-gamma response and an increase in TNF-alpha response in PWM-stimulated cultures.	Vitamin D	0-9	interferon gamma	Bos taurus	55-64
12771291-4	2003	In the myelomonocytic cell line, active vitamin D(3) is known to activate the transcription of both p21 and p27, cyclin-dependent kinase inhibitors (CDKIs), regulating the transition from the G(1) to the S phase of the cell cycle, in a VDR-dependent manner.	Vitamin D	40-49	vitamin D receptor	Homo sapiens	236-239
12771308-2	2003	The klotho gene is involved in the development of a syndrome resembling human ageing, and klotho mutant mice show abnormal calcium/vitamin D metabolism, developing hyperphosphataemia and vascular calcification.	Vitamin D	131-140	klotho	Homo sapiens	4-10
12771308-2	2003	The klotho gene is involved in the development of a syndrome resembling human ageing, and klotho mutant mice show abnormal calcium/vitamin D metabolism, developing hyperphosphataemia and vascular calcification.	Vitamin D	131-140	klotho	Homo sapiens	90-96
12716975-3	2003	Here we present evidence for a similar mechanism in humans via a patient with resistance to the active form of vitamin D [1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))] who presented with normal vitamin D receptor (VDR) expression.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	194-212
12716975-3	2003	Here we present evidence for a similar mechanism in humans via a patient with resistance to the active form of vitamin D [1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))] who presented with normal vitamin D receptor (VDR) expression.	Vitamin D	111-120	vitamin D receptor	Homo sapiens	214-217
12798352-10	2003	The inhibition of FAS expression and cell proliferation by 1alpha,25(OH)(2)D(3) seemed to be androgen-dependent, since antiandrogen, casodex and DCC-treatment of serum blocked the vitamin D action.	Vitamin D	180-189	DCC netrin 1 receptor	Homo sapiens	145-148
12697832-3	2003	In osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by the Runx2/Cbfa1 transcription factor and is stimulated in response to vitamin D(3) via the vitamin D(3) receptor complex.	Vitamin D	178-187	vitamin D receptor	Homo sapiens	199-220
12689675-1	2003	Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	158-176
12689675-1	2003	Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets.	Vitamin D	27-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	178-181
12612432-0	2003	2 alpha-(3-hydroxypropyl)- and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	103-121
12612432-1	2003	Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor, which lead to resistance to 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)].	Vitamin D	11-20	vitamin D receptor	Homo sapiens	96-114
12570725-6	2003	By far the biggest class of vitamin D analogs are the VDR agonists which directly mimic 1alpha,25(OH)(2)D(3) and trigger protein conformational changes in the receptor which lead to changes in the transcriptional machinery at vitamin D-responsive genes.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	54-57
12570725-6	2003	By far the biggest class of vitamin D analogs are the VDR agonists which directly mimic 1alpha,25(OH)(2)D(3) and trigger protein conformational changes in the receptor which lead to changes in the transcriptional machinery at vitamin D-responsive genes.	Vitamin D	226-235	vitamin D receptor	Homo sapiens	54-57
12520539-1	2003	Aiming at new drugs to efficiently treat diseases, in which either increased or decreased levels of active vitamin D are desirable, we have designed some 400 structurally different azole-type inhibitors and examined their capacity to selectively block vitamin D metabolism by CYP24 or synthesis by CYP27B, in human keratinocytes.	Vitamin D	252-261	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	276-281
12520541-6	2003	Biosynthesis of CaBP is fully and CaT1 function is approximately 90% vitamin D-dependent.	Vitamin D	69-78	transient receptor potential cation channel subfamily V member 6	Homo sapiens	34-38
12710998-2	2003	Elucidation of Vitamin D(3) receptor (VDR) regulation may reveal strategies to sensitize cancer cells to the effects of 1,25-dihydroxyvitamin D(3) and Vitamin D(3) analogs.	Vitamin D	15-24	vitamin D receptor	Homo sapiens	38-41
12710998-9	2003	Because resveratrol could up-regulate VDR without increasing breast cancer cell growth, we hypothesized that resveratrol mediated increase in VDR expression would sensitize breast cancer cells to the effects of 1,25-dihydroxyvitamin D(3) and Vitamin D(3) analogs.	Vitamin D	242-251	vitamin D receptor	Homo sapiens	142-145
12710998-10	2003	In support of this hypothesis, both T47D and MCF-7 cells pre-treated with resveratrol exhibited increased VDR mediated transactivation of a Vitamin D(3) responsive promoter compared to cells pre-treated with vehicle.	Vitamin D	140-149	vitamin D receptor	Homo sapiens	106-109
12710998-12	2003	These data support the concept that dietary factors, such as phytoestrogens, may impact on breast cancer cell sensitivity to Vitamin D(3) analogs through regulation of the VDR promoter.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	172-175
14621394-4	2003	The discovery of the vitamin D endocrine system has resulted in the realization that Ca regulation in mammals and birds involves a coordinated effort between the hormones parathyroid hormone (PTH), calcitonin and the hormonally-active form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	Vitamin D	21-30	parathyroid hormone	Bos taurus	171-190
12556238-2	2003	ACP1 encodes a low molecular weight enzyme which is now recognized as a phosphotyrosine phosphatase with a role in the regulation of signal transduction pathways, and GC-globulin acts both as a transporter of vitamin D and as a plasma actin scavenger and plays a role in macrophage activation.	Vitamin D	209-218	acid phosphatase 1	Homo sapiens	0-4
12504839-0	2003	Maternal and postnatal vitamin D ingestion influences rat aortic structure, function and elastin content.	Vitamin D	23-32	elastin	Rattus norvegicus	89-96
18650961-4	2003	Vitamin D exerts its genomic effects through a nuclear gene transcription factor, the vitamin D receptor (VDR), while metabolism of vitamin D both to its biologically active form, as well as to its excretory product, plays a major role in determining biological activity at the tissue level.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	86-104
18650961-4	2003	Vitamin D exerts its genomic effects through a nuclear gene transcription factor, the vitamin D receptor (VDR), while metabolism of vitamin D both to its biologically active form, as well as to its excretory product, plays a major role in determining biological activity at the tissue level.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	106-109
18650961-4	2003	Vitamin D exerts its genomic effects through a nuclear gene transcription factor, the vitamin D receptor (VDR), while metabolism of vitamin D both to its biologically active form, as well as to its excretory product, plays a major role in determining biological activity at the tissue level.	Vitamin D	86-95	vitamin D receptor	Homo sapiens	106-109
14977005-0	2003	[Molecular model of A-ring modified vitamin D bound to VDR].	Vitamin D	36-45	vitamin D receptor	Homo sapiens	55-58
12507934-1	2002	1,25-Dihydroxyvitamin D(3) (1,25D(3)) is the biologically active form of vitamin D(3) that interacts with the nuclear vitamin D(3) receptor (VDR) to modulate gene expression in a tissue-specific fashion.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	118-139
12507934-1	2002	1,25-Dihydroxyvitamin D(3) (1,25D(3)) is the biologically active form of vitamin D(3) that interacts with the nuclear vitamin D(3) receptor (VDR) to modulate gene expression in a tissue-specific fashion.	Vitamin D	14-23	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	141-144
12431109-2	2002	Mutations to the vitamin D receptor (VDR), a member of the nuclear and steroid hormone receptor family, have been linked to human vitamin D-resistant rickets (hVDRR) and result in high serum 1,25(OH)(2)D(3) concentrations and severe bone underdevelopment.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	37-40
12445200-8	2002	The vitamin D response element from the involucrin gene bound the vitamin D receptor and the retinoid X receptor, but not the retinoic acid receptor, in a specific manner.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	66-84
12445200-8	2002	The vitamin D response element from the involucrin gene bound the vitamin D receptor and the retinoid X receptor, but not the retinoic acid receptor, in a specific manner.	Vitamin D	4-13	retinoid X receptor alpha	Homo sapiens	93-112
12421875-5	2002	Levels are determined by skin exposure to ultraviolet light or, to a minor extent, nutritional uptake and by subsequent conversion of the precursor vitamin D to the active hormone by the cytochrome P450 hydroxylases CYP27A1, CYP27B1 (responsible for synthesis) and CYP24 (responsible for catabolism) in liver and kidney.	Vitamin D	148-157	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	265-270
12239126-3	2002	Here we provide evidence that the quantity of product 1,25-(OH)2D generated also relies on the presence and level of expression of the intracellular vitamin D binding protein-1 (IDBP-1) and its capacity to promote 24-hydroxylase (CYP24) gene expression.	Vitamin D	149-158	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	230-235
12036954-1	2002	Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D.	Vitamin D	0-9	crystallin gamma F, pseudogene	Homo sapiens	41-50
12048211-4	2002	The Ets-1 binding site was determined to function cooperatively with the most proximal vitamin D response element in a hormone-dependent fashion.	Vitamin D	87-96	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	4-9
12162499-3	2002	In experiments here, application of 1.8% equibiaxial strain for 6 h reduced vitamin D-stimulated RANKL mRNA expression by nearly one-half in primary bone stromal cells.	Vitamin D	76-85	TNF superfamily member 11	Homo sapiens	97-102
12130690-6	2002	Pregnane X, vitamin D, and thyroid hormone receptors can potentially compete with human CAR on human PBREM.	Vitamin D	12-21	nuclear receptor subfamily 1 group I member 3	Homo sapiens	88-91
12086963-0	2002	Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	0-18
12086963-0	2002	Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians.	Vitamin D	68-77	vitamin D receptor	Homo sapiens	20-23
12044990-0	2002	No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS. Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D.	Vitamin D	18-27	GC vitamin D binding protein	Homo sapiens	93-118
12168894-7	2002	The strong VDR immunoreactivity that we observed in breast cancer specimens supports the body of evidence that breast cancer may be a target for therapeutically applied vitamin D analogues.	Vitamin D	169-178	vitamin D receptor	Homo sapiens	11-14
11972530-3	2002	Because homozygous CC and BB VDR genotypes influence Vitamin D activity, they can be considered additional risk factors for bone disease in beta thalassaemia.	Vitamin D	53-62	vitamin D receptor	Homo sapiens	29-32
11967012-5	2002	In order to study the effect of calcitriol on EGFR gene transcription, a candidate vitamin D-responsive element (VDRE) was identified in the EGFR gene promoter and complimentary 30-mer oligonucleotides spanning this region were tested for binding to recombinant VDR using EMSA.	Vitamin D	83-92	epidermal growth factor receptor	Rattus norvegicus	141-145
11925111-6	2002	BMP7 stimulation led to a decrease of 1,25(OH)2-vitamin D3-induced binding of nuclear proteins to a vitamin D response element, as shown by electrophoretic mobility shift assay.	Vitamin D	48-57	bone morphogenetic protein 7	Homo sapiens	0-4
11920955-1	2002	BACKGROUND: 1,25-dihydroxyvitamin D, the active form of vitamin D, exerts antiproliferative effect on prostatic cells, mediated through the vitamin D receptor.	Vitamin D	26-35	vitamin D receptor	Homo sapiens	140-158
11890700-1	2002	1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene"s promoter.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	94-112
11890700-1	2002	1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene"s promoter.	Vitamin D	14-23	vitamin D receptor	Homo sapiens	114-117
11836628-6	2002	Notch-4 expression could only be detected after stimulation with Dexamethasone and Vitamin D(3).	Vitamin D	83-92	notch receptor 4	Homo sapiens	0-7
11991436-4	2002	Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR).	Vitamin D	23-32	vitamin D receptor	Homo sapiens	101-104
11668178-4	2002	Expression of both C/EBPbeta and C/EBPdelta increases from the growth to maturation developmental stages and, like the bone-specific osteocalcin (OC) gene, is also stimulated 3-6-fold by vitamin D(3), a regulator of osteoblast differentiation.	Vitamin D	187-196	CCAAT/enhancer binding protein beta	Rattus norvegicus	19-28
12362981-5	2002	On the other hand, inhibition of cytosolic phospholipase A2 accelerated the differentiation of HL-60 cells induced by either 1,25-D3 or by the vitamin D analogs suggesting possible existence of a feedback loop between extracellular-signal regulated kinases and phospholipase A2.	Vitamin D	143-152	phospholipase A2 group IVA	Homo sapiens	33-59
12489206-7	2002	Finally, in the same cells, such combinations appeared to modulate VDR expression outlining the existence of complex cross-regulations between vitamin D and Msx/Dix pathways.	Vitamin D	143-152	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	67-70
12006701-5	2002	Two types of vitamin D-dependent hereditary rickets (VDDR) are known to be caused by mutations in the 1alpha(OH)ase and VDR genes.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	120-123
11751444-4	2001	In addition, the interrelation among vitamin D, calcium, and FokI polymorphism of the VDR gene was investigated.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	86-89
11737585-0	2001	p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium.	Vitamin D	59-68	transforming growth factor alpha	Rattus norvegicus	12-21
11697802-1	2001	Immune cells carry receptors for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; vitamin D receptor (VDR)] and individuals with severe vitamin D deficiency have immune abnormalities.	Vitamin D	47-56	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	72-90
11697802-1	2001	Immune cells carry receptors for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; vitamin D receptor (VDR)] and individuals with severe vitamin D deficiency have immune abnormalities.	Vitamin D	47-56	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	92-95
11382777-4	2001	A binding site, the vitamin D response element (VDRE), for a heterodimer of vitamin D receptor (VDR) and retinoic X receptor alpha (RXR alpha) within the slow MyHC3 promoter mediates chamber-specific expression of the gene.	Vitamin D	20-29	retinoid X receptor alpha	Gallus gallus	132-141
11389055-1	2001	Operating through the vitamin D receptor (VDR), vitamin D inhibits prostate cancer growth and increases insulin-like growth factor binding protein (IGFBP) expression, suggesting that the vitamin D and insulin-like growth factor (IGF) regulatory systems may operate together to affect prostate cancer.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	42-45
11389055-1	2001	Operating through the vitamin D receptor (VDR), vitamin D inhibits prostate cancer growth and increases insulin-like growth factor binding protein (IGFBP) expression, suggesting that the vitamin D and insulin-like growth factor (IGF) regulatory systems may operate together to affect prostate cancer.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	22-40
11389055-1	2001	Operating through the vitamin D receptor (VDR), vitamin D inhibits prostate cancer growth and increases insulin-like growth factor binding protein (IGFBP) expression, suggesting that the vitamin D and insulin-like growth factor (IGF) regulatory systems may operate together to affect prostate cancer.	Vitamin D	48-57	vitamin D receptor	Homo sapiens	42-45
11432806-2	2001	The functions of 1,25-dihydroxyvitamin D(3) are mediated through the vitamin D(3) receptor (VDR); therefore, an understanding of the regulation of VDR expression is important when considering the molecular mechanisms of differentiation induced by vitamin D(3) and its analogues.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	69-90
11432806-2	2001	The functions of 1,25-dihydroxyvitamin D(3) are mediated through the vitamin D(3) receptor (VDR); therefore, an understanding of the regulation of VDR expression is important when considering the molecular mechanisms of differentiation induced by vitamin D(3) and its analogues.	Vitamin D	31-40	vitamin D receptor	Homo sapiens	92-95
11344183-0	2001	The role of the vitamin D receptor in regulating vitamin D metabolism: a study of vitamin D-dependent rickets, type II.	Vitamin D	49-58	vitamin D receptor	Homo sapiens	16-34
11344183-1	2001	In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] and 24,25-(OH)(2)D is reciprocally controlled by 1,25-(OH)(2)D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	206-224
11344183-1	2001	In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] and 24,25-(OH)(2)D is reciprocally controlled by 1,25-(OH)(2)D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	226-229
11344183-1	2001	In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] and 24,25-(OH)(2)D is reciprocally controlled by 1,25-(OH)(2)D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR.	Vitamin D	85-94	vitamin D receptor	Homo sapiens	361-364
11344183-9	2001	Thus, 1,25-(OH)(2)D-liganded VDR is a major control mechanism for vitamin D metabolism, and PTH exerts an additive effect.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	29-32
11281654-3	2001	The vitamin D receptor (VDR) is another member of this superfamily, and the vitamin D pathway is important for prevention and therapy of osteoporosis, renal failure, cancer, and psoriasis.	Vitamin D	4-13	vitamin D receptor	Homo sapiens	24-27
11179724-0	2001	Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcription.	Vitamin D	78-87	vitamin D receptor	Homo sapiens	0-18
11159837-5	2001	Nurr1"s importance in retinoic acid, vitamin D, and thyroid hormone signaling has been hypothesized.	Vitamin D	37-46	nuclear receptor subfamily 4, group A, member 2	Mus musculus	0-5
11251690-8	2001	The mechanisms by which the VDR polymorphism is associated with RA is unknown, but they could be related to the immunoregulatory properties of vitamin D.	Vitamin D	143-152	vitamin D receptor	Homo sapiens	28-31
11686044-0	2001	Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24).	Vitamin D	40-49	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	112-117
11145614-2	2001	Mice lacking the vitamin D receptor (VDR) develop the typical features of rickets, establishing that VDR plays a role in controlling the actions of vitamin D.	Vitamin D	17-26	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	37-40
11145614-2	2001	Mice lacking the vitamin D receptor (VDR) develop the typical features of rickets, establishing that VDR plays a role in controlling the actions of vitamin D.	Vitamin D	17-26	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	101-104
11498733-8	2001	Among the Japanese, sensitivity to vitamin D has been reported to vary between the alleles of the VDR; i.e., bone mineral density (BMD) in patients without the B allele is increased by vitamin D treatment, whereas patients with the B allele do not show such an increase in BMD.	Vitamin D	35-44	vitamin D receptor	Homo sapiens	98-101
11498733-8	2001	Among the Japanese, sensitivity to vitamin D has been reported to vary between the alleles of the VDR; i.e., bone mineral density (BMD) in patients without the B allele is increased by vitamin D treatment, whereas patients with the B allele do not show such an increase in BMD.	Vitamin D	185-194	vitamin D receptor	Homo sapiens	98-101
11500919-0	2001	MCF-7/VD(R): a new vitamin D resistant cell line.	Vitamin D	19-28	vitamin D receptor	Homo sapiens	0-11
11500919-9	2001	The MCF-7/VD(R) cell line shows characteristics different from those of previously described vitamin D resistant breast cancer cell lines but also some similarities.	Vitamin D	93-102	vitamin D receptor	Homo sapiens	4-15
11384863-0	2001	Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein.	Vitamin D	16-25	GC vitamin D binding protein	Homo sapiens	169-194
10948206-2	2000	Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	103-125
10948206-2	2000	Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	127-130
10948206-3	2000	We used DNA affinity chromatography to purify proteins associated with non-VDR-VDRE binding activity from vitamin d-resistant New World primate cells.	Vitamin D	106-115	vitamin D receptor	Homo sapiens	75-78
11033763-1	2000	The disorders of vitamin D metabolism are inherited metabolic abnormalities involving mutations of the vitamin D receptor or enzymes involved in the metabolism of vitamin D to its biologically active form 1,25-dihydroxyvitamin D.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	103-121
10976917-1	2000	Previously recognized intracellular proteins with an affinity for vitamin D metabolites include the vitamin D receptor and the cytochrome P-450-based vitamin D metabolizing mixed-function oxidases.	Vitamin D	66-75	vitamin D receptor	Homo sapiens	100-118
10976917-6	2000	Transfection experiments also demonstrated that the majority of the constitutively expressed 25-hydroxylated vitamin D metabolite binding activity was attributable to expression of the hsc-70-related IDBP-1 and that metabolite binding activity sublocalized to the highly conserved ATP-binding/ATPase domain of hsp-70s.	Vitamin D	109-118	heat shock protein family A (Hsp70) member 8	Homo sapiens	185-191
10976917-6	2000	Transfection experiments also demonstrated that the majority of the constitutively expressed 25-hydroxylated vitamin D metabolite binding activity was attributable to expression of the hsc-70-related IDBP-1 and that metabolite binding activity sublocalized to the highly conserved ATP-binding/ATPase domain of hsp-70s.	Vitamin D	109-118	heat shock protein family A (Hsp70) member 4	Homo sapiens	310-316
10976917-7	2000	Stable overexpression of IDBP-1 in wild-type cells enhanced vitamin D-directed responsiveness of endogenous vitamin D-24-hydroxylase, osteopontin, and osteocalcin genes by several-fold over that observed in cells transfected with an empty vector.	Vitamin D	60-69	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	108-132
10875271-1	2000	The 25-hydroxyvitamin D-24-hydroxylase enzyme (24-OHase) is responsible for the catabolic breakdown of 1,25-dihydroxyvitamin D [1,25(OH)2D], the active form of vitamin D.	Vitamin D	14-23	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	47-55
10875271-6	2000	Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development.	Vitamin D	88-97	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	56-64
10828302-6	2000	Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses.	Vitamin D	29-38	GC vitamin D binding protein	Homo sapiens	395-420
10828304-9	2000	Using this VDR model, the structure-function relationship of highly potent vitamin D analogs was discussed.	Vitamin D	75-84	vitamin D receptor	Homo sapiens	11-14
10828305-1	2000	Vitamin D analogs in which the triene moiety is replaced by an aromatic ring have been synthesized and their ability to bind to the vitamin D receptor investigated.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	132-150
10890574-2	2000	The DBP found in the emydid family of turtles is unique in that it exhibits high-affinity binding of both vitamin D and thyroxine (D/TBP).	Vitamin D	106-115	TATA-box binding protein	Homo sapiens	133-136
10843188-1	2000	Vitamin D, via its receptor (VDR), inhibits the hormone secretion and proliferation of parathyroid cells.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	29-32
10773761-1	2000	BACKGROUND/AIMS: It is known that allelic variants of the gene encoding the vitamin-D receptor (VDR) detected by BsmI increase the risk of some advanced malignant tumors, suggesting that such variants may cause functional differences in 1,25(OH)(2) vitamin D(3).	Vitamin D	249-258	vitamin D receptor	Homo sapiens	76-94
10773761-1	2000	BACKGROUND/AIMS: It is known that allelic variants of the gene encoding the vitamin-D receptor (VDR) detected by BsmI increase the risk of some advanced malignant tumors, suggesting that such variants may cause functional differences in 1,25(OH)(2) vitamin D(3).	Vitamin D	249-258	vitamin D receptor	Homo sapiens	96-99
10646127-6	2000	These active vitamin D compounds also counteracted the effects of PTHrP at the proximal renal tubules, as reflected by a decrease in phosphate excretion.	Vitamin D	13-22	parathyroid hormone-like hormone	Rattus norvegicus	66-71
10653974-1	2000	We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	83-101
10653974-1	2000	We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself.	Vitamin D	50-59	vitamin D receptor	Homo sapiens	103-106
18475933-0	2000	Role of vitamin d on the inhibition of gastrin production after Cisplatin treatment.	Vitamin D	8-17	gastrin	Rattus norvegicus	39-46
18475933-10	2000	In vivo, however, vitamin D and calcium were equally effective in preventing gastrin mRNA loss.	Vitamin D	18-27	gastrin	Rattus norvegicus	77-84
10597185-5	1999	In breast cancer, low vitamin D levels in serum are correlated with disease progression and bone metastases, a situation also noted in prostate cancer and suggesting the involvement of the VDR.	Vitamin D	22-31	vitamin D receptor	Homo sapiens	189-192
10605626-15	1999	Interactions between genetic and environmental factors, including lifestyle, have been investigated initially for the VDR polymorphisms in relation to the response of bone density and turnover to calcium intake and treatment with simple vitamin D and active vitamin D compounds.	Vitamin D	237-246	vitamin D receptor	Homo sapiens	118-121
10605626-15	1999	Interactions between genetic and environmental factors, including lifestyle, have been investigated initially for the VDR polymorphisms in relation to the response of bone density and turnover to calcium intake and treatment with simple vitamin D and active vitamin D compounds.	Vitamin D	258-267	vitamin D receptor	Homo sapiens	118-121
10633464-6	1999	In some analogs the serum binding protein (DBP) plays a key role in determining the pharmacokinetics of the vitamin D compound.	Vitamin D	108-117	growth hormone receptor	Homo sapiens	20-41
10512735-8	1999	The truncation at the N terminus markedly impairs the ability of CYP27A to use 1alpha-hydroxyvitamin D(3) as substrate and to catalyze 25-hydroxylation in the bioactivation of vitamin D(3).	Vitamin D	93-102	sterol 26-hydroxylase, mitochondrial	Oryctolagus cuniculus	65-70
10516141-1	1999	Dietary restriction of phosphate is a well-known stimulator (acting indirectly via vitamin D(3)) of small intestinal apical Na-P(i) cotransport.	Vitamin D	83-92	catenin, beta like 1	Mus musculus	124-128
10516141-6	1999	It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene.	Vitamin D	88-97	catenin, beta like 1	Mus musculus	47-51
10516141-6	1999	It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene.	Vitamin D	88-97	catenin, beta like 1	Mus musculus	153-157
10516141-6	1999	It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene.	Vitamin D	88-97	catenin, beta like 1	Mus musculus	153-157
10485974-1	1999	Vitamin D binding protein (DBP) is a major carrier protein for the vitamin D metabolites, but may also play an important role in osteoclast differentiation.	Vitamin D	67-76	GC vitamin D binding protein	Homo sapiens	0-25
10477499-14	1999	In the MIR 97 mission high calcium intake and vitamin D supplementation led to high ionized calcium levels and a marked decrease in calcitriol levels together with decreased bone formation and increased bone resorption markers.	Vitamin D	46-55	membrane associated ring-CH-type finger 8	Homo sapiens	7-10
10454569-3	1999	Here we show that the classical growth factor insulin-like growth factor I (IGF-I) potently promotes vitamin D(3)-induced macrophage differentiation of promyeloid cells, as assessed by measurement of a coordinate increase in expression of the integrin alpha subunit CD11b, the CD14 lipopolysaccharide receptor, and the macrophage-specific esterase, alpha-naphthyl acetate esterase, as early as 24 h following initiation of terminal differentiation.	Vitamin D	101-110	integrin subunit alpha M	Homo sapiens	266-271
10446999-6	1999	VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene.	Vitamin D	143-152	vitamin D receptor	Homo sapiens	0-3
10446999-6	1999	VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene.	Vitamin D	210-219	vitamin D receptor	Homo sapiens	0-3
10385391-1	1999	Prior studies have shown that 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] plays a major role in resting zone chondrocyte differentiation and that this vitamin D metabolite regulates both phospholipase A2 and protein kinase C (PKC) specific activities.	Vitamin D	45-54	protein kinase C, alpha	Rattus norvegicus	224-227
10336890-8	1999	Binding of RXR/VDR heterodimers to DRs with different transcriptional outcomes may generate selectivity and provide a greater complexity and flexibility to the vitamin D responses.	Vitamin D	160-169	retinoid X receptor alpha	Homo sapiens	11-14
10336890-8	1999	Binding of RXR/VDR heterodimers to DRs with different transcriptional outcomes may generate selectivity and provide a greater complexity and flexibility to the vitamin D responses.	Vitamin D	160-169	vitamin D receptor	Homo sapiens	15-18
10224044-6	1999	Taken together, our results strongly suggest that the interplay between the TGF-beta and vitamin D signaling pathways is, at least in part, mediated by the two classes of Smad proteins, which modulate VDR transactivation function both positively and negatively.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	201-204
10037600-2	1999	Vitamin D controls transcription of target genes through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	61-79
10037600-2	1999	Vitamin D controls transcription of target genes through the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	81-84
10100926-3	1999	The aims of the present study were to examine (1) if calcitonin (CT), parathyroid hormone (PTH) and vitamin D affect the gastrin-ECL-cell axis (by measuring the activity of the histamine-forming enzyme, histidine decarboxylase (HDC), and the expression of HDC mRNA and CGA mRNA in the ECL cells), and (2) if activation of the gastrin-ECL-cell axis affects the parathyroid glands (by measuring plasma PTH and mRNA expression).	Vitamin D	100-109	gastrin	Rattus norvegicus	121-128
10064337-2	1999	In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation.	Vitamin D	74-83	vitamin D receptor	Homo sapiens	95-98
10064337-2	1999	In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation.	Vitamin D	277-286	vitamin D receptor	Homo sapiens	74-93
10064337-2	1999	In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation.	Vitamin D	277-286	vitamin D receptor	Homo sapiens	95-98
10064337-2	1999	In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation.	Vitamin D	277-286	vitamin D receptor	Homo sapiens	215-218
10079704-1	1999	Calcitriol, the active metabolite of vitamin D, is a steroid hormone that regulates calcium metabolism and cell differentiation by interacting with its nuclear receptor--the vitamin D receptor (VDR)--and by stimulating gene transcription.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	174-192
10079704-1	1999	Calcitriol, the active metabolite of vitamin D, is a steroid hormone that regulates calcium metabolism and cell differentiation by interacting with its nuclear receptor--the vitamin D receptor (VDR)--and by stimulating gene transcription.	Vitamin D	37-46	vitamin D receptor	Homo sapiens	194-197
11056661-3	1999	Discoordinate regulation by vitamin D of MMP-1 and MMP-9 in human mononuclear phagocytes has also been reported.	Vitamin D	28-37	matrix metallopeptidase 9	Homo sapiens	51-56
10323682-4	1999	Vitamin D analogues with poor affinity for the vitamin D receptor were found to effectively stimulate PI turnover, suggesting the presence of a unique vitamin D receptor in the BLM.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	47-65
10323682-4	1999	Vitamin D analogues with poor affinity for the vitamin D receptor were found to effectively stimulate PI turnover, suggesting the presence of a unique vitamin D receptor in the BLM.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	151-169
9972311-1	1998	The apparent high degree of homology of a blood protein with a unique dual binding affinity for two distinct hormones, thyroxin (T4) and vitamin D, isolated from a turtle, Trachemys scripta (Family Emydidae) and mammalian vitamin D binding protein (DBP) prompted further interspecific comparison to better understand the structure of functional binding sites.	Vitamin D	137-146	GC vitamin D binding protein	Homo sapiens	222-247
9774468-1	1998	Vitamin D-binding protein (DBP)/Gc-globulin, the major carrier of vitamin D and its metabolites in blood, is synthesized predominantly in the liver in a developmentally regulated fashion.	Vitamin D	66-75	GC vitamin D binding protein	Homo sapiens	0-25
9774468-1	1998	Vitamin D-binding protein (DBP)/Gc-globulin, the major carrier of vitamin D and its metabolites in blood, is synthesized predominantly in the liver in a developmentally regulated fashion.	Vitamin D	66-75	GC vitamin D binding protein	Homo sapiens	32-43
10101442-10	1998	Results from this study suggest that faster bone mineral loss and more exaggerated disturbances of vitamin D metabolism are present in haemodialyzed uraemic patients with BB than bb genotype of VDR.	Vitamin D	99-108	vitamin D receptor	Homo sapiens	194-197
9753201-4	1998	Using the mouse Schwann cell line, MSC80, we showed that concentrations as low as 10(-10) M of hormone stimulated the expression of the VDR gene and strongly increased the amounts of activated VDR, capable of binding to the specific vitamin D responsive element (VDRE).	Vitamin D	233-242	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	193-196
9682036-3	1998	VDR is a ligand-inducible transcription factor which heterodimerizes with retinoid X receptor (RXR) and binds as a heterodimer to vitamin D-responsive elements (VDREs) in the promoter region of vitamin-D responsive genes, ultimately leading to their increased transcription.	Vitamin D	130-139	vitamin D receptor	Homo sapiens	0-3
9682036-3	1998	VDR is a ligand-inducible transcription factor which heterodimerizes with retinoid X receptor (RXR) and binds as a heterodimer to vitamin D-responsive elements (VDREs) in the promoter region of vitamin-D responsive genes, ultimately leading to their increased transcription.	Vitamin D	194-203	vitamin D receptor	Homo sapiens	0-3
9682036-6	1998	These interactions have a role in linking the VDR-RXR heterodimer to the transcriptional pre-initiation complex (PIC) and in regulating the transcription of vitamin D-dependent genes.	Vitamin D	157-166	vitamin D receptor	Homo sapiens	46-49
9682036-6	1998	These interactions have a role in linking the VDR-RXR heterodimer to the transcriptional pre-initiation complex (PIC) and in regulating the transcription of vitamin D-dependent genes.	Vitamin D	157-166	retinoid X receptor alpha	Homo sapiens	50-53
9682036-8	1998	The complex interplay that occurs between VDR and these various factors to determine the overall transcriptional activity of vitamin D-responsive genes will be summarized.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	42-45
9783909-1	1998	To characterize further the function of the intracellular vitamin D receptor (VDR), we have developed stable transfectant variants of a vitamin D-responsive cell line (U937) which express either decreased or increased numbers of VDR.	Vitamin D	58-67	vitamin D receptor	Homo sapiens	78-81
9665874-4	1998	Second, deficiencies of protein, zinc and vitamin D impair T-cell functions, including decreased production of the Th1 cytokines IL-2 and IFN-gamma, and depressed dermal tuberculin reactions and PPD-induced lymphoproliferation in guinea pigs and mice infected with virulent Mycobacterium tuberculosis.	Vitamin D	42-51	interleukin-2	Cavia porcellus	129-133
9702072-4	1998	Vitamin D-dependent rickets type II is associated with the abnormality of the VDR function, leading to target organ resistance to 1,25(OH)2D3.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	78-81
9687155-1	1998	Repression of basal transcription of a 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) responsive 25-hydroxyvitamin D3-24-hydroxylase (CYP24) promoter construct as observed in kidney cells in the absence of ligand and this repression was dependent on a functional vitamin D response element (VDRE).	Vitamin D	53-62	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	127-132
9600069-6	1998	Our results strongly suggest the existence of a feedback mechanism in that UVB initiates vitamin D synthesis in keratinocytes and at the same time limits VDR abundance.	Vitamin D	89-98	vitamin D receptor	Homo sapiens	154-157
9541187-0	1998	Expression of a vitamin D-regulated gene (VDUP-1) in untreated- and MNU-treated rat mammary tissue.	Vitamin D	16-25	thioredoxin interacting protein	Rattus norvegicus	42-48
9502615-7	1998	Signals from VD3 are predominantly mediated by VDR and the ligand-activated binding of VDR to vitamin D-responsive element (VDRE) as a heterodimer with the retinoid X receptor (RXR).	Vitamin D	94-103	retinoid X receptor alpha	Homo sapiens	156-175
9502615-7	1998	Signals from VD3 are predominantly mediated by VDR and the ligand-activated binding of VDR to vitamin D-responsive element (VDRE) as a heterodimer with the retinoid X receptor (RXR).	Vitamin D	94-103	retinoid X receptor alpha	Homo sapiens	177-180
9368060-0	1997	Identification of a novel suppressive vitamin D response sequence in the 5"-flanking region of the murine Id1 gene.	Vitamin D	38-47	inhibitor of DNA binding 1, HLH protein	Mus musculus	106-109
9368060-9	1997	These results indicate the involvement of the novel 57-bp sequence in the vitamin D suppression of Id1 gene transcription.	Vitamin D	74-83	inhibitor of DNA binding 1, HLH protein	Mus musculus	99-102
9344589-0	1997	Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D.	Vitamin D	178-187	retinoid X receptor alpha	Homo sapiens	58-67
9344589-0	1997	Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D.	Vitamin D	178-187	retinoid X receptor alpha	Homo sapiens	93-102
9295274-4	1997	These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR.	Vitamin D	71-80	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	137-140
9379138-4	1997	In hereditary hypocalcemic vitamin D-resistant rickets (HVDRR), natural mutations in human VDR that confer patients with tissue insensitivity to 1,25(OH)2D3 are particularly instructive in revealing VDR structure function relationships.	Vitamin D	27-36	vitamin D receptor	Homo sapiens	91-94
9379138-14	1997	The above events, including bridging by coactivators to the TATA binding protein and associated factors, may position VDR such that it is able to attract TFIIB and the balance of the RNA polymerase II transcription machinery, culminating in repeated transcriptional initiation of VDRE-containing, vitamin D target genes.	Vitamin D	297-306	TATA-box binding protein	Homo sapiens	60-80
9379138-14	1997	The above events, including bridging by coactivators to the TATA binding protein and associated factors, may position VDR such that it is able to attract TFIIB and the balance of the RNA polymerase II transcription machinery, culminating in repeated transcriptional initiation of VDRE-containing, vitamin D target genes.	Vitamin D	297-306	vitamin D receptor	Homo sapiens	118-121
9815816-0	1997	Three synthetic vitamin D analogues induce prostate-specific acid phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion.	Vitamin D	16-25	vitamin D receptor	Homo sapiens	172-190
9210418-9	1997	Vitamin D responsiveness of the NaPi-3 promoter was also detected in COS-7 cells co-transfected with a human vitamin D receptor expression vector.	Vitamin D	0-9	vitamin D receptor	Homo sapiens	109-127
9165580-2	1997	Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	61-79
9165580-2	1997	Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR).	Vitamin D	0-9	vitamin D receptor	Homo sapiens	81-84
9165580-11	1997	Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D"s effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients.	Vitamin D	115-124	vitamin D receptor	Homo sapiens	43-46
9165580-11	1997	Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D"s effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients.	Vitamin D	152-161	vitamin D receptor	Homo sapiens	43-46
9165580-11	1997	Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D"s effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients.	Vitamin D	152-161	vitamin D receptor	Homo sapiens	43-46
9058382-0	1997	Analysis of vitamin D analog-induced heterodimerization of vitamin D receptor with retinoid X receptor using the yeast two-hybrid system.	Vitamin D	12-21	vitamin D receptor	Homo sapiens	59-77
9058382-5	1997	We used the yeast two-hybrid system to evaluate a series of six vitamin D analogs for their ability to induce VDR-RXR heterodimerization.	Vitamin D	64-73	vitamin D receptor	Homo sapiens	110-113
9058382-5	1997	We used the yeast two-hybrid system to evaluate a series of six vitamin D analogs for their ability to induce VDR-RXR heterodimerization.	Vitamin D	64-73	retinoid X receptor alpha	Homo sapiens	114-117
9010343-1	1996	The nature of the DNA binding interactions of the human vitamin D receptor (hVDR) with the murine osteopontin vitamin D response element (mOP VDRE) was examined.	Vitamin D	56-65	vitamin D receptor	Homo sapiens	76-80
9010343-12	1996	From these results we infer that homodimers of the hVDR which respond with enhanced DNA binding to particular vitamin D response elements when exposed to 1,25-(OH)2D3 are possible.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	51-55
8961271-2	1996	Two novel point mutations (I314S and R391C) identified in the hormone-binding domain of the human vitamin D receptor (VDR) from patients with hereditary hypocalcemic vitamin D-resistant rickets confer the receptor with sharply reduced 1,25-(OH)2D3-dependent transactivation.	Vitamin D	98-107	vitamin D receptor	Homo sapiens	118-121
8918619-2	1996	Hyperphosphatemia in vivo is associated with alterations of calcium and vitamin D levels, both of which are known to alter the parathyroid hormone (PTH) release independently.	Vitamin D	72-81	parathyroid hormone	Bos taurus	127-146
8678897-2	1996	One such analog is the vitamin D2 metabolite, 1 alpha,24(S)-dihydroxyvitamin D2, which binds strongly to the vitamin D receptor and induces vitamin D-dependent gene expression in vitro.	Vitamin D	23-32	vitamin D receptor	Homo sapiens	109-127
8687373-1	1996	The biologically active metabolite of vitamin D (cholecalciferol), i.e. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a secosteroid hormone whose mode of action involves stereospecific interaction with an intracellular receptor protein (vitamin D receptor; VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	234-252
8687373-1	1996	The biologically active metabolite of vitamin D (cholecalciferol), i.e. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a secosteroid hormone whose mode of action involves stereospecific interaction with an intracellular receptor protein (vitamin D receptor; VDR).	Vitamin D	38-47	vitamin D receptor	Homo sapiens	254-257
8687373-6	1996	The VDR binds to vitamin D-responsive elements (VDREs) in the 5" flanking region of target genes.	Vitamin D	17-26	vitamin D receptor	Homo sapiens	4-7
8761938-8	1996	In addition, the full-length VDR fusion protein was shown by gel shift analysis to bind weakly to the human osteocalcin gene vitamin D response element, an interaction greatly facilitated by addition of RXR alpha.	Vitamin D	125-134	vitamin D receptor	Homo sapiens	29-32
8761938-8	1996	In addition, the full-length VDR fusion protein was shown by gel shift analysis to bind weakly to the human osteocalcin gene vitamin D response element, an interaction greatly facilitated by addition of RXR alpha.	Vitamin D	125-134	retinoid X receptor alpha	Homo sapiens	203-212
8752659-1	1996	The biologic effects of the vitamin D hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are believed to be mediated by an intracellular vitamin D receptor, which after ligand binding acts as a transcription factor modulating expression of a variety of genes.	Vitamin D	28-37	vitamin D receptor	Homo sapiens	133-151
8752663-8	1996	The inhibition of collagen gel contraction by 1,25-D3 is supposed to be mediated by the vitamin D receptor because a functional vitamin D receptor is required, and vitamin D metabolites with low affinity to the vitamin D receptor were inactive.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	128-146
8752663-8	1996	The inhibition of collagen gel contraction by 1,25-D3 is supposed to be mediated by the vitamin D receptor because a functional vitamin D receptor is required, and vitamin D metabolites with low affinity to the vitamin D receptor were inactive.	Vitamin D	88-97	vitamin D receptor	Homo sapiens	128-146
8734984-2	1996	The aim of the present study was to test whether the vitamin D-dependent Ca(2+)-binding protein calbindin-D9k could function as an important cytosolic Ca2+ buffer in duodenal enterocytes while facilitating transepithelial active transport of Ca2+ ions.	Vitamin D	53-62	S100 calcium binding protein G	Sus scrofa	96-109
8651937-9	1996	In gel shift assays, the binding of vitamin D receptor to the composite AP-1 plus vitamin-D responsive promoter region of the human osteocalcin gene after EB 1089 treatment was stronger and longer-lasting than after calcitriol treatment.	Vitamin D	82-91	vitamin D receptor	Homo sapiens	36-54
9156521-1	1996	The receptor for the active metabolite of vitamin D, 1,25(OH)(2)D(3), known as the vitamin D receptor (VDR), belongs to the steroid hormone nuclear receptor superfamily.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	83-101
9156521-1	1996	The receptor for the active metabolite of vitamin D, 1,25(OH)(2)D(3), known as the vitamin D receptor (VDR), belongs to the steroid hormone nuclear receptor superfamily.	Vitamin D	42-51	vitamin D receptor	Homo sapiens	103-106
8833658-0	1996	Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor.	Vitamin D	69-78	vitamin D receptor	Homo sapiens	0-18
8593831-7	1996	In addition, vitamin D-resistant cell nuclear extract contained a protein(s) which was bound specifically to the VDRE and was capable of completely inhibiting VDR-RXR-VDRE complex formation; these effects were not demonstrated with nuclear extract from the wild type cell line or with the post-nuclear extract of the vitamin D-resistant cell line.	Vitamin D	13-22	vitamin D receptor	Homo sapiens	113-116
8593831-7	1996	In addition, vitamin D-resistant cell nuclear extract contained a protein(s) which was bound specifically to the VDRE and was capable of completely inhibiting VDR-RXR-VDRE complex formation; these effects were not demonstrated with nuclear extract from the wild type cell line or with the post-nuclear extract of the vitamin D-resistant cell line.	Vitamin D	13-22	retinoid X receptor alpha	Homo sapiens	163-166
8593831-7	1996	In addition, vitamin D-resistant cell nuclear extract contained a protein(s) which was bound specifically to the VDRE and was capable of completely inhibiting VDR-RXR-VDRE complex formation; these effects were not demonstrated with nuclear extract from the wild type cell line or with the post-nuclear extract of the vitamin D-resistant cell line.	Vitamin D	317-326	vitamin D receptor	Homo sapiens	113-116
8566748-5	1996	Furthermore, we show that p21 is transcriptionally induced by 1,25-dihydroxyvitamin D3 in a VDR-dependent, but not p53-dependent, manner, and we identify a functional vitamin D response element in the p21 promoter.	Vitamin D	76-85	vitamin D receptor	Homo sapiens	92-95
9084640-6	1996	The TATA box is overlapped by a vitamin D3 response element (VDRE) which appears to mediate vitamin D suppression of BSP gene transcription by competing with the TATA-binding protein (TBP) for occupancy of the site of the pre-initiation complex formation.	Vitamin D	32-41	TATA-box binding protein	Homo sapiens	184-187
9084648-2	1996	TGF beta and vitamin D metabolites when added separately to resting zone (RC) or growth zone (GC) chondrocyte cultures, activate protein kinase C (PKC).	Vitamin D	13-22	protein kinase C, gamma	Rattus norvegicus	129-145
9084648-2	1996	TGF beta and vitamin D metabolites when added separately to resting zone (RC) or growth zone (GC) chondrocyte cultures, activate protein kinase C (PKC).	Vitamin D	13-22	protein kinase C, gamma	Rattus norvegicus	147-150
8723391-4	1996	Human thyroid hormone, retinoic acid, vitamin D, and several orphan receptors prefer to work as heterodimers with retinoic X receptor (RXR).	Vitamin D	38-47	retinoid X receptor alpha	Homo sapiens	135-138
7489414-9	1995	As the b allele has been linked to decreased transcriptional activity or messenger RNA stability, reduced VDR expression may impede regulatory actions of vitamin D and may contribute to parathyroid tumorigenesis in these patients.	Vitamin D	154-163	vitamin D receptor	Homo sapiens	106-109
8674817-1	1995	Vitamin D3 receptors (VDR) bind as heterodimers with retinoid X receptors (RXR) to vitamin D response elements (VDRE) and transactivate gene expression in a 1,25(OH)2D3-dependent manner.	Vitamin D	83-92	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-20
8674817-1	1995	Vitamin D3 receptors (VDR) bind as heterodimers with retinoid X receptors (RXR) to vitamin D response elements (VDRE) and transactivate gene expression in a 1,25(OH)2D3-dependent manner.	Vitamin D	83-92	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	22-25
7544121-0	1995	Vitamin-D-dependent transcriptional regulation of the intestinal plasma membrane calcium pump.	Vitamin D	0-9	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	65-93
7544121-1	1995	The vitamin D hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], was shown to increase intestinal plasma membrane calcium pump (PMCA) gene expression.	Vitamin D	4-13	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	96-124
7544121-1	1995	The vitamin D hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], was shown to increase intestinal plasma membrane calcium pump (PMCA) gene expression.	Vitamin D	4-13	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	126-130
7646451-5	1995	1 alpha,24(S)-Dihydroxyvitamin D2 binds strongly to the vitamin D receptor and is biologically active in growth hormone and chloramphenicol acetyltransferase reporter gene expression systems in vitro, but binds poorly to rat vitamin D-binding globulin, DBP.	Vitamin D	23-32	D-box binding PAR bZIP transcription factor	Rattus norvegicus	253-256
8579895-1	1995	The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive elements (VDREs).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	32-35
8579895-8	1995	Recent data reveal that after binding RXR, a subsequent target for VDR in the vitamin D signal transduction cascade is basal transcription factor IIB (TFIIB).	Vitamin D	78-87	retinoid X receptor alpha	Homo sapiens	38-41
8579895-8	1995	Recent data reveal that after binding RXR, a subsequent target for VDR in the vitamin D signal transduction cascade is basal transcription factor IIB (TFIIB).	Vitamin D	78-87	vitamin D receptor	Homo sapiens	67-70
7566512-4	1995	Cyclic AMP stimulated peptide secretion from the cells were not affected by vitamin D, but cyclic AMP mediated increase in CCK peptide concentration was significantly inhibited by vitamin D (p &lt; 0.05).	Vitamin D	180-189	cholecystokinin	Rattus norvegicus	123-126
7626513-2	1995	Identical to the group specific component (Gc-globulin) of serum, the protein is a single-chain polypeptide constitutively synthesized in liver that circulates in amounts in far excess of normal vitamin D metabolite concentrations in blood.	Vitamin D	195-204	GC vitamin D binding protein	Homo sapiens	43-54
7626514-1	1995	The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) hormone with high affinity and elicits its actions to stimulate gene expression in target cells by binding to the vitamin D-responsive element (VDRE).	Vitamin D	12-21	vitamin D receptor	Homo sapiens	32-35
7626514-4	1995	The expressed hVDR displays strict dependence on the family of retinoid X receptors (RXRs) for binding to the vitamin D-responsive element (VDRE) in the rat osteocalcin gene.	Vitamin D	110-119	vitamin D receptor	Homo sapiens	14-18
7606167-1	1995	During the course of our studies to probe the vitamin D ligand-binding domains of vitamin D-binding protein and vitamin D receptor, we developed a synthetic procedure to modify the 3 beta-hydroxyl group of vitamin D3 and its 25-hydroxy- and 1,25-dihydroxy metabolites with a 3"-aminopropylether group.	Vitamin D	46-55	GC vitamin D binding protein	Homo sapiens	82-107
7878015-1	1995	The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily.	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	128-146
7878015-1	1995	The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily.	Vitamin D	25-34	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	148-151
7872065-0	1994	Activation of the human osteocalcin gene by 24R,25-dihydroxyvitamin D3 occurs through the vitamin D receptor and the vitamin D-responsive element.	Vitamin D	60-69	vitamin D receptor	Homo sapiens	90-108
7828346-1	1994	OBJECTIVE: Hereditary vitamin D resistant rickets (HVDRR) has been shown to be due to mutations in the gene encoding the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	121-139
7828346-1	1994	OBJECTIVE: Hereditary vitamin D resistant rickets (HVDRR) has been shown to be due to mutations in the gene encoding the vitamin D receptor (VDR).	Vitamin D	22-31	vitamin D receptor	Homo sapiens	52-55