PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18397956-9	2008	IL-20R1 and IL-20R2 (IL-20Rs) were expressed in both the lining and sublining layers of RA synovium.	Radium	88-90	interleukin 20 receptor subunit alpha	Homo sapiens	0-7
18397956-9	2008	IL-20R1 and IL-20R2 (IL-20Rs) were expressed in both the lining and sublining layers of RA synovium.	Radium	88-90	interleukin 20 receptor subunit beta	Homo sapiens	12-19
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	55-58
18373956-11	2008	In addition, RA produced a dose-dependent increase of CYP1A1 mRNA and activity (EROD) levels without concomitant increase in AhR2 isoforms.	Radium	13-15	cytochrome P450, family 1, subfamily A	Salmo salar	54-60
18373956-13	2008	The PCB-77-induced CYP1A1, UGT1 and GSTpi (mRNA and activity) levels were modulated by RA, in a parameter and dose-specific manner.	Radium	87-89	cytochrome P450, family 1, subfamily A	Salmo salar	19-25
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	59-63
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	64-68
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	164-170
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	248-251
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	252-256
18280804-5	2008	Our data also establish that ATRA- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21(Waf1/Cip1) gene.	Radium	31-33	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	257-261
18312132-8	2008	Chymase activity predominated (75% to 85%) in the RA system of the cardiac tissues of cats.	Radium	50-52	chymase 1	Felis catus	0-7
18416830-2	2008	Here, we have demonstrated that the observed effects using ATRA and 9-cis RA are shared with the clinically useful RAR ligand, 13-cis retinoic acid (13-cis RA), and the retinoic acid receptor-alpha (RAR-alpha)-selective agonist, AM580 but not with the RAR-beta/gamma ligand, 4-hydroxyphenylretinamide (4-HPR).	Radium	61-63	retinoic acid receptor alpha	Homo sapiens	199-208
18416830-2	2008	Here, we have demonstrated that the observed effects using ATRA and 9-cis RA are shared with the clinically useful RAR ligand, 13-cis retinoic acid (13-cis RA), and the retinoic acid receptor-alpha (RAR-alpha)-selective agonist, AM580 but not with the RAR-beta/gamma ligand, 4-hydroxyphenylretinamide (4-HPR).	Radium	61-63	retinoic acid receptor beta	Homo sapiens	252-260
18416830-2	2008	Here, we have demonstrated that the observed effects using ATRA and 9-cis RA are shared with the clinically useful RAR ligand, 13-cis retinoic acid (13-cis RA), and the retinoic acid receptor-alpha (RAR-alpha)-selective agonist, AM580 but not with the RAR-beta/gamma ligand, 4-hydroxyphenylretinamide (4-HPR).	Radium	74-76	retinoic acid receptor alpha	Homo sapiens	169-197
18416830-2	2008	Here, we have demonstrated that the observed effects using ATRA and 9-cis RA are shared with the clinically useful RAR ligand, 13-cis retinoic acid (13-cis RA), and the retinoic acid receptor-alpha (RAR-alpha)-selective agonist, AM580 but not with the RAR-beta/gamma ligand, 4-hydroxyphenylretinamide (4-HPR).	Radium	74-76	retinoic acid receptor alpha	Homo sapiens	199-208
18416830-2	2008	Here, we have demonstrated that the observed effects using ATRA and 9-cis RA are shared with the clinically useful RAR ligand, 13-cis retinoic acid (13-cis RA), and the retinoic acid receptor-alpha (RAR-alpha)-selective agonist, AM580 but not with the RAR-beta/gamma ligand, 4-hydroxyphenylretinamide (4-HPR).	Radium	74-76	retinoic acid receptor beta	Homo sapiens	252-260
18171623-2	2008	The recent discovery of (pro)renin receptor (PRR) has reinforced the functional role of the RA system.	Radium	92-94	ATPase H+ transporting accessory protein 2	Homo sapiens	29-43
18171623-2	2008	The recent discovery of (pro)renin receptor (PRR) has reinforced the functional role of the RA system.	Radium	92-94	ATPase H+ transporting accessory protein 2	Homo sapiens	45-48
18089636-3	2008	Osteoclasts are specialized macrophage/monocyte lineage-derived cells that resorb bone and NF1 haploinsufficient osteoclasts have abnormal Ras-dependent bone resorption.	Radium	139-142	neurofibromin 1	Homo sapiens	91-94
18317594-8	2008	Furthermore, apoptosis in response to 13-cis RA was inhibited in the presence of siRNA to lipocalin 2.	Radium	45-47	lipocalin 2	Homo sapiens	90-101
18179184-3	2008	These data were then used to simulate RA spectra of SAMs with different content of defects and to compare them with experiments.	Radium	38-40	methionine adenosyltransferase 1A	Homo sapiens	52-56
18268322-8	2008	In contrast, the kinase domain mutation is active in the absence of RAS-GTP binding but is highly dependent on the interaction with p85.	Radium	68-71	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	132-135
18268322-9	2008	We speculate that the contrasting roles of p85 and RAS-GTP in helical and kinase domain mutations reflect two distinct states of mutated p110alpha.	Radium	51-54	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	137-146
18179184-8	2008	For this family of SAMs, the presence of about 10% of all-trans conformers gives a satisfactory quantitative agreement between the calculated RA spectra and experimental observations.	Radium	142-144	methionine adenosyltransferase 1A	Homo sapiens	19-23
18068127-4	2008	We found that retinaldehyde (Rald), a molecule that can yield RA through the action of retinaldehyde dehydrogenases (Raldh), is present in fat in vivo and can inhibit PPAR gamma-induced adipogenesis.	Radium	62-64	peroxisome proliferator activated receptor gamma	Mus musculus	167-177
18272044-9	2008	AT(1)RA inhibited angiotensin II induced proliferation of HSCs.	Radium	5-7	angiotensinogen	Rattus norvegicus	18-32
18974614-7	2008	These data lead us to hypothesize that biologically active forms of RA suppress the expression of UGT2B7 in intestinal cells.	Radium	68-70	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	98-104
18637482-17	2008	In order to abrogate growth factor induced hypersensitivity, we have utilized a drug, farnesylthiosalicylic acid, which blocks the binding of GTP-Ras to its membrane acceptor protein, galectin 1 and reduces the activation of MAP kinase.	Radium	146-149	galectin 1	Homo sapiens	184-194
19388360-9	2008	FINDINGS: Elevated AQP4 expression levels and water content were observed on the right injured side in both the right anterior (RA) and right posterior (RP) section compared to the left non-injured side inclusive of the left anterior (LA) and right anterior (RA) sections.	Radium	128-130	aquaporin 4	Rattus norvegicus	19-23
17530703-1	2007	OBJECTIVE: Recently, Swedish members of the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) provided evidence that smoking may trigger RA-specific immune reactions to citrullinated protein in carriers of HLA-DR shared epitope alleles.	Radium	101-103	major histocompatibility complex, class II, DR beta 1	Homo sapiens	217-220
18076762-10	2007	CCR2 RA-[R] treatment of nerve-injured rats produced stereospecific bilateral reversal of tactile hyperalgesia.	Radium	5-7	C-C motif chemokine receptor 2	Rattus norvegicus	0-4
17978505-7	2007	The results provide pragmatic evidence for H4R as a novel target in the development of pharmacotherapeutic agents for RA treatment.	Radium	118-120	histamine receptor H4	Homo sapiens	43-46
17664148-3	2007	To test this hypothesis in a cell culture system, we exposed A549 cells to 95% O(2) (Ox) for 48 h followed by recovery in room air (RA) for 24 h. We found that Ox increased VEGF protein two- to threefold within the medium at 48 h of exposure and during recovery.	Radium	132-134	vascular endothelial growth factor A	Homo sapiens	173-177
17613434-4	2007	In RA-treated PML/RARA-transformed cells, the absence of RXR binding results in monocytic, rather than granulocytic, differentiation.	Radium	3-5	promyelocytic leukemia	Mus musculus	14-17
17613434-4	2007	In RA-treated PML/RARA-transformed cells, the absence of RXR binding results in monocytic, rather than granulocytic, differentiation.	Radium	3-5	retinoic acid receptor, alpha	Mus musculus	18-22
17976380-0	2007	Locked 5Zs-biliverdin blocks the Meta-RA to Meta-RC transition in the functional cycle of bacteriophytochrome Agp1.	Radium	38-40	orosomucoid 1	Homo sapiens	110-114
17265154-1	2007	We conducted a comprehensive meta-analysis with all available data on the association of allele and genotype of peptidylarginine deiminases 4 (PADI4) polymorphisms with RA overall and in each ethnic population to explore whether the PADI4 polymorphisms confer susceptibility to RA.	Radium	169-171	peptidyl arginine deiminase 4	Homo sapiens	112-141
17265154-1	2007	We conducted a comprehensive meta-analysis with all available data on the association of allele and genotype of peptidylarginine deiminases 4 (PADI4) polymorphisms with RA overall and in each ethnic population to explore whether the PADI4 polymorphisms confer susceptibility to RA.	Radium	169-171	peptidyl arginine deiminase 4	Homo sapiens	143-148
17265154-6	2007	The presence of 2/2 genotype of the PADI4 significantly increased the risk for RA in European populations (OR = 2.10, 95% CI, 1.66-2.66, P < 0.0001) without between-study heterogeneity (I (2) = 44.3, P = 0.15).	Radium	79-81	peptidyl arginine deiminase 4	Homo sapiens	36-41
17265154-7	2007	In conclusion, this meta-analysis demonstrates that the PADI4 polymorphisms may represent a significant risk factor for RA in Asians and Europeans and may play a larger role in susceptibility to RA in Asian than in European populations.	Radium	120-122	peptidyl arginine deiminase 4	Homo sapiens	56-61
17265154-7	2007	In conclusion, this meta-analysis demonstrates that the PADI4 polymorphisms may represent a significant risk factor for RA in Asians and Europeans and may play a larger role in susceptibility to RA in Asian than in European populations.	Radium	195-197	peptidyl arginine deiminase 4	Homo sapiens	56-61
17440594-11	2007	MVD estimated by FVIII-RA staining of group Adp53+F56, Adp53 and F56 were 14.50+/-2.54, 16.28+/-3.44 and 18.06+/-7.66, compared with control group(24.93+/-6.53), the difference is significant (P=0.000).	Radium	23-25	coagulation factor VIII	Mus musculus	17-22
17674773-5	2007	These results showed that different concentrations of 9-cis RA could promote or inhibit the differentiation of pig preadipocyting by regulating the expressions of RXRalpha and PPARgamma.	Radium	60-62	retinoid X receptor alpha	Sus scrofa	163-171
17674773-5	2007	These results showed that different concentrations of 9-cis RA could promote or inhibit the differentiation of pig preadipocyting by regulating the expressions of RXRalpha and PPARgamma.	Radium	60-62	peroxisome proliferator activated receptor gamma	Sus scrofa	176-185
17335085-8	2007	Indeed, NT2.Nurr1 cells, at 4 weeks into RA treatment, displayed more abundant tyrosine hydroxylase positive cells than NT2 cells.	Radium	41-43	nuclear receptor subfamily 4 group A member 2	Homo sapiens	12-17
17365667-5	2007	RESULTS: In WT cells, H/RA but not H/RS rapidly phosphorylated ERK1/2 and JNK1 and subsequently increased ROS production.	Radium	24-26	mitogen-activated protein kinase 3	Mus musculus	63-69
17214633-8	2007	RA inhibited the expression of S100A8/A9 and keratinocyte differentiation, which were induced by interleukin-1alpha.	Radium	0-2	S100 calcium binding protein A8	Homo sapiens	31-37
17214633-8	2007	RA inhibited the expression of S100A8/A9 and keratinocyte differentiation, which were induced by interleukin-1alpha.	Radium	0-2	interleukin 1 alpha	Homo sapiens	97-115
17365667-5	2007	RESULTS: In WT cells, H/RA but not H/RS rapidly phosphorylated ERK1/2 and JNK1 and subsequently increased ROS production.	Radium	24-26	mitogen-activated protein kinase 8	Mus musculus	74-78
17433708-2	2007	Serine 64 in the transactivation domain of C/EBPbeta has recently been identified as a Ras-induced phosphoacceptor site.	Radium	87-90	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	43-52
17365667-8	2007	ROS increase during H/RA was prevented by deletion of gp91phox or p47phox, or MAPK inhibition.	Radium	22-24	cytochrome b-245, beta polypeptide	Mus musculus	54-62
17365667-8	2007	ROS increase during H/RA was prevented by deletion of gp91phox or p47phox, or MAPK inhibition.	Radium	22-24	neutrophil cytosolic factor 1	Mus musculus	66-73
17035100-10	2007	Furthermore, tsh1 expression was down-regulated in the spinal cord in the zebrafish neckless mutant in which RA signaling is disrupted due to a missense mutation in the gene encoding retinaldehyde dehydrogenase type 2.	Radium	109-111	teashirt zinc finger homeobox 1	Danio rerio	13-17
17341023-2	2007	This report deals with the design and X-ray crystallography data of new synthetic, low-molecular weight cyanopeptide-analogues, RA-1008 and RA-1014, complexed with human alpha-thrombin at 1.85 A resolution.	Radium	128-130	coagulation factor II, thrombin	Homo sapiens	176-184
17341023-4	2007	The strongest member of the second series of described thrombin inhibitors, RA-1014, shows in the crystal complex with thrombin a slightly higher affinity towards the enzyme than RA-1008 as confirmed by inhibition tests.	Radium	76-78	coagulation factor II, thrombin	Homo sapiens	55-63
17341023-4	2007	The strongest member of the second series of described thrombin inhibitors, RA-1014, shows in the crystal complex with thrombin a slightly higher affinity towards the enzyme than RA-1008 as confirmed by inhibition tests.	Radium	76-78	coagulation factor II, thrombin	Homo sapiens	119-127
17257050-4	2007	We apply RA to thymocyte development by reproducing and extending the effects of known gene knockouts: CXCR4 and CCR9.	Radium	9-11	C-X-C motif chemokine receptor 4	Homo sapiens	103-108
17257050-4	2007	We apply RA to thymocyte development by reproducing and extending the effects of known gene knockouts: CXCR4 and CCR9.	Radium	9-11	C-C motif chemokine receptor 9	Homo sapiens	113-117
17184907-3	2007	Several peptides including D22, PGC1alpha, SRC3-2, PRIP/RAP250 and SRC1-4 also formed a complex with RXRbeta LBD in the presence of all-trans retinoic acid (at-RA) and the fatty acids, phytanic acid (PA) and docosahexaenoic acid (DHA).	Radium	56-58	nuclear receptor coactivator 6	Homo sapiens	51-55
17184907-3	2007	Several peptides including D22, PGC1alpha, SRC3-2, PRIP/RAP250 and SRC1-4 also formed a complex with RXRbeta LBD in the presence of all-trans retinoic acid (at-RA) and the fatty acids, phytanic acid (PA) and docosahexaenoic acid (DHA).	Radium	56-58	retinoid X receptor beta	Homo sapiens	101-108
16856944-0	2006	RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.	Radium	0-2	adenylate cyclase	Saccharomyces cerevisiae S288C	34-39
17005618-8	2007	Two types of HVC projection neurons-premotor and striatal projecting-respond differently to the NIf drive, in agreement with notions of HVC relaying premotor signals to RA and an anticipatory copy thereof to areas of a basal ganglia pathway.	Radium	169-171	S100 calcium binding protein A9	Homo sapiens	96-99
17166371-13	2006	CONCLUSION: 9-Cis RA could induce G1 phase arrest and apoptosis in MGC803 cells through down-regulating the expression of cell cycle factors Cyclin D1 and CDK4.	Radium	18-20	cyclin D1	Homo sapiens	141-150
17166371-13	2006	CONCLUSION: 9-Cis RA could induce G1 phase arrest and apoptosis in MGC803 cells through down-regulating the expression of cell cycle factors Cyclin D1 and CDK4.	Radium	18-20	cyclin dependent kinase 4	Homo sapiens	155-159
17064357-9	2006	Based on these findings, we speculate that Raf-1 is activated to effectively mediate Ras-dependent signals in Alzheimer"s disease.	Radium	85-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	43-48
17005281-2	2006	Expression of human SOX3 gene is modulated during the RA-induced neuronal differentiation cascade of NT2/D1 cells.	Radium	54-56	SRY-box transcription factor 3	Homo sapiens	20-24
16908535-9	2006	Additionally, Kras2-mutant tumors exhibited substantially higher levels of ras-GTP, phospho-Erk1/2, and phospho-Mek1/2 compared to Hras1-mutant tumors, suggesting the involvement of the ras/mitogen-activated protein kinase (MAPK) pathway in the acquisition of oncogene independence.	Radium	15-18	mitogen-activated protein kinase kinase 1	Mus musculus	112-118
16908535-9	2006	Additionally, Kras2-mutant tumors exhibited substantially higher levels of ras-GTP, phospho-Erk1/2, and phospho-Mek1/2 compared to Hras1-mutant tumors, suggesting the involvement of the ras/mitogen-activated protein kinase (MAPK) pathway in the acquisition of oncogene independence.	Radium	15-18	Harvey rat sarcoma virus oncogene	Mus musculus	131-136
16860305-2	2006	We show here that RARbeta2 is expressed predominantly in dorsal root ganglia (DRG) neuronal subtypes that express neurofilament (NF) 200 and calcitonin gene-related peptide (CGRP), and that these neurons extend neurites in response to RA.	Radium	18-20	neurofilament, heavy polypeptide	Mus musculus	114-136
16860305-2	2006	We show here that RARbeta2 is expressed predominantly in dorsal root ganglia (DRG) neuronal subtypes that express neurofilament (NF) 200 and calcitonin gene-related peptide (CGRP), and that these neurons extend neurites in response to RA.	Radium	18-20	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	141-172
16860305-2	2006	We show here that RARbeta2 is expressed predominantly in dorsal root ganglia (DRG) neuronal subtypes that express neurofilament (NF) 200 and calcitonin gene-related peptide (CGRP), and that these neurons extend neurites in response to RA.	Radium	18-20	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	174-178
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Radium	38-40	tumor necrosis factor	Mus musculus	124-133
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Radium	38-40	interleukin 1 beta	Mus musculus	135-143
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Radium	38-40	interleukin 6	Mus musculus	145-149
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Radium	38-40	mast cell protease 1	Mus musculus	155-160
17386168-11	2007	The Fas/APO-1 levels in patients of RA group higher than those of Non-RA group at baseline [(13.82 +/- 4.36) microg/L vs (8.19 +/- 3.56) microg/L, P < 0.01].	Radium	36-38	Fas cell surface death receptor	Homo sapiens	8-13
17386168-11	2007	The Fas/APO-1 levels in patients of RA group higher than those of Non-RA group at baseline [(13.82 +/- 4.36) microg/L vs (8.19 +/- 3.56) microg/L, P < 0.01].	Radium	70-72	Fas cell surface death receptor	Homo sapiens	8-13
17386168-13	2007	The highest level of Fas/APO-1 was on 7 d after AMI and the plasma levels of Fas/APO-1 in 2 - 4 W were slightly lower than those in 7 d in the two groups [RA group: (10.91 +/- 3.65) microg/L vs (14.26 +/- 4.98) microg/L, P < 0.05; Non-RA group: (4.69 +/- 1.87) microg/L vs (12.19 +/- 3.25) microg/L, P < 0.01].	Radium	155-157	Fas cell surface death receptor	Homo sapiens	81-86
17386168-14	2007	However, the Fas/APO-1 level of 2 - 4 W in RA group was slightly higher than the level in Non-RA group [(10.91 +/- 3.65) microg/L vs (4.69 +/- 1.87) microg/L, P < 0.01].	Radium	43-45	Fas cell surface death receptor	Homo sapiens	17-22
17003410-11	2006	Ski has been shown to repress transcription induced by retinoic acid signaling, and may thus affect ocular development by regulating RA signaling.	Radium	133-135	ski sarcoma viral oncogene homolog (avian)	Mus musculus	0-3
17369931-2	2006	A correlation was found between the increase in chemiluminescence (Re-LPS<Ra-LPS<S-LPS) and lengthening of the polysaccharide chain in endotoxins.	Radium	77-79	interferon regulatory factor 6	Homo sapiens	70-73
17369931-2	2006	A correlation was found between the increase in chemiluminescence (Re-LPS<Ra-LPS<S-LPS) and lengthening of the polysaccharide chain in endotoxins.	Radium	77-79	interferon regulatory factor 6	Homo sapiens	80-83
17369931-2	2006	A correlation was found between the increase in chemiluminescence (Re-LPS<Ra-LPS<S-LPS) and lengthening of the polysaccharide chain in endotoxins.	Radium	77-79	interferon regulatory factor 6	Homo sapiens	80-83
16856944-0	2006	RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.	Radium	0-2	Ras family GTPase RAS1	Saccharomyces cerevisiae S288C	45-49
16856944-10	2006	These results suggest an essential role for the RA-mediated Ras1-Cdc35 interaction in raising cellular cAMP levels for hyphal morphogenesis.	Radium	48-50	Ras family GTPase RAS1	Saccharomyces cerevisiae S288C	60-64
16856944-10	2006	These results suggest an essential role for the RA-mediated Ras1-Cdc35 interaction in raising cellular cAMP levels for hyphal morphogenesis.	Radium	48-50	adenylate cyclase	Saccharomyces cerevisiae S288C	65-70
16688770-7	2006	To perform these actions RA is synthesized in the adjacent paraxial mesoderm by the enzyme RALDH2 and acts in a paracrine fashion on the developing neural tube.	Radium	25-27	aldehyde dehydrogenase 1 family member A2	Homo sapiens	91-97
16740703-6	2006	K-ras and B-Raf mutations were assessed by PCR and Ras activation by the ratio Ras-GTP / (Ras-GTP + Ras-GDP).	Radium	51-54	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	10-15
16005186-5	2006	RIG1 reduced the levels of activated Ras (Ras-GTP) and total Ras protein in cells transfected with mutated H-, N-, or K-Ras(G12V), or in cells transfected with the wild type H- or N-Ras followed by stimulation with epidermal growth factor.	Radium	37-40	phospholipase A and acyltransferase 4	Homo sapiens	0-4
16698549-4	2006	The interaction of Ras/Rap1-GTP with the RA domain of mNore1 is weakened significantly by direct binding of the C1 domain to the RA domain.	Radium	19-22	RAP1A, member of RAS oncogene family	Homo sapiens	23-27
16698549-4	2006	The interaction of Ras/Rap1-GTP with the RA domain of mNore1 is weakened significantly by direct binding of the C1 domain to the RA domain.	Radium	19-22	Ras association (RalGDS/AF-6) domain family member 5	Mus musculus	54-60
16698549-4	2006	The interaction of Ras/Rap1-GTP with the RA domain of mNore1 is weakened significantly by direct binding of the C1 domain to the RA domain.	Radium	41-43	RAP1A, member of RAS oncogene family	Homo sapiens	23-27
16698549-4	2006	The interaction of Ras/Rap1-GTP with the RA domain of mNore1 is weakened significantly by direct binding of the C1 domain to the RA domain.	Radium	41-43	Ras association (RalGDS/AF-6) domain family member 5	Mus musculus	54-60
16933718-6	2006	The average MVD per x400 in the cases of RA was 5.7 +/- 4.7 with a median value of 4.65 (range 19) whereas it was 45.4 +/- 10.0 and 44.0 (range 27.3) respectively in RAEB and RAEB-t (p <.001), the 95% confidence interval being (2.94, 8.5) and (36.6, 54.3), for the two groups respectively.	Radium	41-43	mevalonate diphosphate decarboxylase	Homo sapiens	12-15
16706851-7	2006	The PKC immunoreactivity increased in RA of the intact hemisphere; however, in RA on the lesioned side, it was less intense than that of the unlesioned side.	Radium	38-40	proline rich transmembrane protein 2	Homo sapiens	4-7
16528475-7	2006	Mitochondrial release of cytochrome c after paclitaxel alone or in combination with RA was weak, however robust Smac release was observed.	Radium	84-86	cytochrome c, somatic	Homo sapiens	25-37
16528475-8	2006	While RA/paclitaxel-treated MCF-7 (pcDNA3) cultures contained condensed apoptotic nuclei, MCF-7(survivin-S) nuclei were morphologically distinct with hypercondensed disorganized chromatin and released mitochondrial AIF-1.	Radium	6-8	allograft inflammatory factor 1	Homo sapiens	215-220
16528475-9	2006	RA also reduced paclitaxel-associated levels of cyclin B1 expression consistent with mitotic exit.	Radium	0-2	cyclin B1	Homo sapiens	48-57
16236778-6	2006	We hypothesized that the RA signal, the strength of which increases with vibratory frequency, interfered with the spatially modulated signal conveyed by SA1 fibers.	Radium	25-27	stromal antigen 1	Homo sapiens	153-156
15959780-1	2005	The chemotherapeutic effects of all-trans-retinoic acid (atRA) are mediated by the retinoic acid receptor beta (RARbeta), but RARbeta expression is reduced in a number of head and neck carcinoma (HNSCC) cells which causes resistance to RA treatment in half the patients with HNSCC.	Radium	59-61	retinoic acid receptor beta	Homo sapiens	83-110
16316996-6	2006	Deletion of the cyclic AMP-binding domain overcame the need for nucleotide, suggesting that this domain normally masked the RA domain in the resting GEF.	Radium	124-126	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	149-152
16410076-10	2006	Taken together, these data for the first time demonstrated a role for RA-induced hypochondrogenesis through regulation of the TGF-beta3 pathway and suggested a role for TbetaRII /Smad in retinoid-induced cleft palate.	Radium	70-72	transforming growth factor, beta 3	Mus musculus	126-135
16306046-8	2006	That the mechanical repression of RANKL requires activation of H-Ras, a specific isoform of Ras-GTP that is known to reside in the lipid raft microdomain, suggests that spatial arrangements are critical for generation of specific downstream events in response to mechanical signals.	Radium	65-68	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	34-39
16364719-10	2006	RESULTS: Treatment with the ET(A)-RA significantly reduced the severity of I/R injury evidenced by lower serum AST, ALT and GLDH.	Radium	34-36	AST	Sus scrofa	111-114
15959780-1	2005	The chemotherapeutic effects of all-trans-retinoic acid (atRA) are mediated by the retinoic acid receptor beta (RARbeta), but RARbeta expression is reduced in a number of head and neck carcinoma (HNSCC) cells which causes resistance to RA treatment in half the patients with HNSCC.	Radium	59-61	retinoic acid receptor beta	Homo sapiens	112-119
15959780-2	2005	The possible mechanism for the reduced RARbeta expression has been suggested as the methylation of the CpG islands adjacent to the RA response elements (RARE) in the RARbeta promoter and the loss of histone acetylation.	Radium	39-41	retinoic acid receptor beta	Homo sapiens	166-173
16052483-6	2005	By contrast, cell treatment with RA increased apoptosis and IL-2 synthesis.	Radium	33-35	interleukin 2	Homo sapiens	60-64
16256040-5	2005	CONCLUSION: Anti-VEGF neutralizing antibody can significantly inhibit synovial fibroblast proliferation, neovascularization and angeitis genesis, which made it a promising agent for RA treatment.	Radium	182-184	vascular endothelial growth factor A	Mus musculus	17-21
16140268-6	2005	Moreover, nuclear retention of STAT3 RA by a chromosomal region maintenance 1 (CRM1) inhibitor, leptomycin B, decreased the enhanced STAT3 activation by stimuli.	Radium	37-39	signal transducer and activator of transcription 3	Homo sapiens	31-36
16140268-6	2005	Moreover, nuclear retention of STAT3 RA by a chromosomal region maintenance 1 (CRM1) inhibitor, leptomycin B, decreased the enhanced STAT3 activation by stimuli.	Radium	37-39	exportin 1	Homo sapiens	45-77
16140268-6	2005	Moreover, nuclear retention of STAT3 RA by a chromosomal region maintenance 1 (CRM1) inhibitor, leptomycin B, decreased the enhanced STAT3 activation by stimuli.	Radium	37-39	exportin 1	Homo sapiens	79-83
16140268-6	2005	Moreover, nuclear retention of STAT3 RA by a chromosomal region maintenance 1 (CRM1) inhibitor, leptomycin B, decreased the enhanced STAT3 activation by stimuli.	Radium	37-39	signal transducer and activator of transcription 3	Homo sapiens	133-138
15989786-1	2005	AIM: To explore the effect of retinoic acid (RA)on C3 and factor B (Bf) secretion by human alveolar type II epithelial cell line A549 induced with cytokines.	Radium	45-47	complement C3	Homo sapiens	51-66
16173241-6	2005	RESULTS: The basal level of serum GH in the RA group was significantly higher than in the control group.	Radium	44-46	growth hormone 1	Homo sapiens	34-36
16173241-7	2005	After experiencing mirthful laughter, the level of serum GH in the RA group significantly decreased, approaching that in the control group.	Radium	67-69	growth hormone 1	Homo sapiens	57-59
16173241-8	2005	The serum IGF-1 level was lower in the RA group than in the control group.	Radium	39-41	insulin like growth factor 1	Homo sapiens	10-15
16173241-10	2005	CONCLUSION: The basal level of serum GH in the RA group was significantly higher than in the control group, and the level of serum GH significantly decreased after experiencing mirthful laughter These results suggest that the homeostasis of GH in patients with RA is disturbed, and the increased serum GH levels in RA patients may be associated with their stress condition.	Radium	47-49	growth hormone 1	Homo sapiens	37-39
16173241-10	2005	CONCLUSION: The basal level of serum GH in the RA group was significantly higher than in the control group, and the level of serum GH significantly decreased after experiencing mirthful laughter These results suggest that the homeostasis of GH in patients with RA is disturbed, and the increased serum GH levels in RA patients may be associated with their stress condition.	Radium	261-263	growth hormone 1	Homo sapiens	131-133
16173241-10	2005	CONCLUSION: The basal level of serum GH in the RA group was significantly higher than in the control group, and the level of serum GH significantly decreased after experiencing mirthful laughter These results suggest that the homeostasis of GH in patients with RA is disturbed, and the increased serum GH levels in RA patients may be associated with their stress condition.	Radium	261-263	growth hormone 1	Homo sapiens	131-133
16173241-10	2005	CONCLUSION: The basal level of serum GH in the RA group was significantly higher than in the control group, and the level of serum GH significantly decreased after experiencing mirthful laughter These results suggest that the homeostasis of GH in patients with RA is disturbed, and the increased serum GH levels in RA patients may be associated with their stress condition.	Radium	261-263	growth hormone 1	Homo sapiens	131-133
15986375-5	2005	The effects of MT1-MMPalphaS on the invasiveness of RASFs were analyzed in the SCID mouse co-implantation model of RA.	Radium	52-54	metallothionein 1	Mus musculus	15-18
15929942-8	2005	This was confirmed by experiments where PABP was inactivated with poly(rA) or Paip2, and the effect of both treatments was reversed by addition of recombinant PABP.	Radium	71-73	poly(A) binding protein cytoplasmic 1	Homo sapiens	40-44
15929942-8	2005	This was confirmed by experiments where PABP was inactivated with poly(rA) or Paip2, and the effect of both treatments was reversed by addition of recombinant PABP.	Radium	71-73	poly(A) binding protein cytoplasmic 1	Homo sapiens	159-163
16115031-5	2005	AngII-induced MCP-1 protein expression in mProx at 6 h was largely blocked by ROS (N-acetylcysteine; 82 +/- 14%), Ras (N-acetyl-S-trans,trans-farnesyl-L-cysteine; 82 +/- 13%), and nuclear factor-kappaB (NF-kappaB) (parthenolide; 89 +/- 7.9%) inhibitors.	Radium	114-117	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-5
16115031-5	2005	AngII-induced MCP-1 protein expression in mProx at 6 h was largely blocked by ROS (N-acetylcysteine; 82 +/- 14%), Ras (N-acetyl-S-trans,trans-farnesyl-L-cysteine; 82 +/- 13%), and nuclear factor-kappaB (NF-kappaB) (parthenolide; 89 +/- 7.9%) inhibitors.	Radium	114-117	chemokine (C-C motif) ligand 2	Mus musculus	14-19
15892121-7	2005	poly(rU) has a triple point ([Cd2+] approximately 10(-4)M) at which the helix-coil (2 --> 1) transition is replaced with a disproportion transition 2AU --> A2U + poly(rA) (2 --> 3) and the subsequent destruction of the triple helix (3 --> 1).	Radium	173-175	CD2 molecule	Homo sapiens	30-33
15892121-11	2005	The T(m) (3-->1) value is practically unchanged up to [Cd2+] approximately 10(-3)M. Differences between diagrams for Mg(2+) and Cd2+ result from the various kinds of ion binding to poly(rA).poly-(rU) and poly(rA).	Radium	189-191	CD2 molecule	Homo sapiens	58-61
15892121-11	2005	The T(m) (3-->1) value is practically unchanged up to [Cd2+] approximately 10(-3)M. Differences between diagrams for Mg(2+) and Cd2+ result from the various kinds of ion binding to poly(rA).poly-(rU) and poly(rA).	Radium	189-191	CD2 molecule	Homo sapiens	131-134
15892121-11	2005	The T(m) (3-->1) value is practically unchanged up to [Cd2+] approximately 10(-3)M. Differences between diagrams for Mg(2+) and Cd2+ result from the various kinds of ion binding to poly(rA).poly-(rU) and poly(rA).	Radium	212-214	CD2 molecule	Homo sapiens	58-61
15892121-11	2005	The T(m) (3-->1) value is practically unchanged up to [Cd2+] approximately 10(-3)M. Differences between diagrams for Mg(2+) and Cd2+ result from the various kinds of ion binding to poly(rA).poly-(rU) and poly(rA).	Radium	212-214	CD2 molecule	Homo sapiens	131-134
16138848-3	2005	Priming of a protective response by RA larvae is a highly co-ordinated series of events starting in the skin, draining lymph nodes and lungs, leading to the development of various effector responses, ranging from Th1-associated cell-mediated activity, to anti-parasitic antibodies, all of which contribute to the elimination of challenge larvae to varying extents.	Radium	36-38	negative elongation factor complex member C/D	Homo sapiens	213-216
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	tumor necrosis factor	Homo sapiens	86-95
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	interleukin 1 beta	Homo sapiens	97-105
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	interleukin 6	Homo sapiens	107-111
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	interferon gamma	Homo sapiens	116-125
15922265-7	2005	The proportion of RA classified as scar was 31% +/- 14% (range 11%-46%).	Radium	18-20	ribosomal protein S4 X-linked	Homo sapiens	35-39
15644459-6	2005	By use of plasma enrichments, insulin decreased methionine rate of appearance (Ra; both methyl- and carbon Ra) by 25% (P < 0.003 vs. basal) and methionine disposal into proteins by 50% (P < 0.0005), whereas it increased homocysteine clearance by approximately 70% (P < 0.025).	Radium	79-81	insulin	Homo sapiens	30-37
15644459-6	2005	By use of plasma enrichments, insulin decreased methionine rate of appearance (Ra; both methyl- and carbon Ra) by 25% (P < 0.003 vs. basal) and methionine disposal into proteins by 50% (P < 0.0005), whereas it increased homocysteine clearance by approximately 70% (P < 0.025).	Radium	107-109	insulin	Homo sapiens	30-37
15790515-4	2005	Increasing concentrations of 9-cis RA inhibited phytohaemagglutinin (PHA)-induced proliferation of T-cells, an effect that could be mimicked only by addition of RARgamma agonists and could be inhibited by an RARgamma antagonist.	Radium	35-37	retinoic acid receptor gamma	Homo sapiens	161-169
15695534-2	2005	MATERIALS AND METHODS: The South Swedish Arthritis Treatment Group register (SSATG) comprises over 90% of anti-TNF treated patients with RA in the area.	Radium	137-139	tumor necrosis factor	Homo sapiens	111-114
15763472-6	2005	The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media.	Radium	18-20	pitrilysin metallopeptidase 1	Homo sapiens	91-94
15761728-7	2005	However, synovial fluid ACE levels were significantly higher in the patients with RA than in patients with OA.	Radium	82-84	angiotensin I converting enzyme	Homo sapiens	24-27
15886301-3	2005	In this report, we show that the ACK-1 isoform of ACK plays a critical role in transducing Ras-Cdc42 signals in the NIH 3T3 cells.	Radium	91-94	tyrosine kinase, non-receptor, 2	Mus musculus	33-38
15886301-3	2005	In this report, we show that the ACK-1 isoform of ACK plays a critical role in transducing Ras-Cdc42 signals in the NIH 3T3 cells.	Radium	91-94	anti-Corynebacterium kutscheri	Mus musculus	33-36
15886301-3	2005	In this report, we show that the ACK-1 isoform of ACK plays a critical role in transducing Ras-Cdc42 signals in the NIH 3T3 cells.	Radium	91-94	cell division cycle 42	Mus musculus	95-100
15790515-4	2005	Increasing concentrations of 9-cis RA inhibited phytohaemagglutinin (PHA)-induced proliferation of T-cells, an effect that could be mimicked only by addition of RARgamma agonists and could be inhibited by an RARgamma antagonist.	Radium	35-37	retinoic acid receptor gamma	Homo sapiens	208-216
15711535-0	2005	Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.	Radium	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	18-23
15850670-9	2005	This suggests that 15d-PGJ(2) and 9-cis RA inhibit cell activation through the formation of PPAR-gamma/RXR heterodimers.	Radium	40-42	peroxisome proliferator activated receptor gamma	Homo sapiens	92-102
15850670-9	2005	This suggests that 15d-PGJ(2) and 9-cis RA inhibit cell activation through the formation of PPAR-gamma/RXR heterodimers.	Radium	40-42	retinoid X receptor alpha	Homo sapiens	103-106
15808511-8	2005	PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription.	Radium	66-68	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
15808511-8	2005	PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription.	Radium	66-68	cyclin dependent kinase 8	Homo sapiens	115-119
15808511-8	2005	PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription.	Radium	66-68	cyclin dependent kinase 8	Homo sapiens	137-141
15808511-8	2005	PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription.	Radium	66-68	retinoic acid receptor alpha	Homo sapiens	153-156
15711535-0	2005	Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.	Radium	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	55-94
15589822-2	2004	These RA-induced effects were further enhanced by the concurrent treatment of HL-60 cells with p38 map kinase inhibitor SB203580 (SB).	Radium	6-8	mitogen-activated protein kinase 14	Homo sapiens	95-98
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	Radium	89-91	retinoic acid receptor responder 1	Homo sapiens	0-25
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	Radium	89-91	retinoic acid receptor responder 1	Homo sapiens	27-31
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	Radium	89-91	phospholipase A and acyltransferase 4	Homo sapiens	37-62
15455391-1	2005	Tazarotene-induced gene 1 (TIG1) and Tazarotene-induced gene 3 (TIG3) are retinoid acid (RA) target genes as well as candidate tumor suppressor genes in human cancers.	Radium	89-91	phospholipase A and acyltransferase 4	Homo sapiens	64-68
15799394-0	2005	[Lesson from ACR guidelines for management of RA].	Radium	46-48	acrosin	Homo sapiens	13-16
15857749-5	2005	Kinetic analysis revealed dissociation constants (KD) of 9-cis RA-preincubated RXR to SRC-1 was 5.92 x 10(-8)M. Using this technique, we found that 1 microM HX531 reduced the ka value of liganded-RXR with SRC-1, suggesting that HX531 reduced the affinity of RXR to SRC-1.	Radium	63-65	retinoid X receptor alpha	Homo sapiens	79-82
15857749-5	2005	Kinetic analysis revealed dissociation constants (KD) of 9-cis RA-preincubated RXR to SRC-1 was 5.92 x 10(-8)M. Using this technique, we found that 1 microM HX531 reduced the ka value of liganded-RXR with SRC-1, suggesting that HX531 reduced the affinity of RXR to SRC-1.	Radium	63-65	nuclear receptor coactivator 1	Homo sapiens	86-91
15857749-5	2005	Kinetic analysis revealed dissociation constants (KD) of 9-cis RA-preincubated RXR to SRC-1 was 5.92 x 10(-8)M. Using this technique, we found that 1 microM HX531 reduced the ka value of liganded-RXR with SRC-1, suggesting that HX531 reduced the affinity of RXR to SRC-1.	Radium	63-65	retinoid X receptor alpha	Homo sapiens	196-199
15857749-5	2005	Kinetic analysis revealed dissociation constants (KD) of 9-cis RA-preincubated RXR to SRC-1 was 5.92 x 10(-8)M. Using this technique, we found that 1 microM HX531 reduced the ka value of liganded-RXR with SRC-1, suggesting that HX531 reduced the affinity of RXR to SRC-1.	Radium	63-65	nuclear receptor coactivator 1	Homo sapiens	205-210
15857749-5	2005	Kinetic analysis revealed dissociation constants (KD) of 9-cis RA-preincubated RXR to SRC-1 was 5.92 x 10(-8)M. Using this technique, we found that 1 microM HX531 reduced the ka value of liganded-RXR with SRC-1, suggesting that HX531 reduced the affinity of RXR to SRC-1.	Radium	63-65	retinoid X receptor alpha	Homo sapiens	196-199
15857749-5	2005	Kinetic analysis revealed dissociation constants (KD) of 9-cis RA-preincubated RXR to SRC-1 was 5.92 x 10(-8)M. Using this technique, we found that 1 microM HX531 reduced the ka value of liganded-RXR with SRC-1, suggesting that HX531 reduced the affinity of RXR to SRC-1.	Radium	63-65	nuclear receptor coactivator 1	Homo sapiens	205-210
15596140-5	2005	In RA-treated F9 teratocarcinoma cell, the mDaIP2 and mDab2 genes were differentially expressed in a RA-responsive manner and both were detected to localize in cytoplasm and nucleus.	Radium	3-5	nitric oxide synthase trafficker	Mus musculus	43-49
15596140-5	2005	In RA-treated F9 teratocarcinoma cell, the mDaIP2 and mDab2 genes were differentially expressed in a RA-responsive manner and both were detected to localize in cytoplasm and nucleus.	Radium	3-5	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	54-59
15589822-3	2004	It seems that there is a strong correlation of nucleophosmin/B23 and c-Myc expressions in cells under RA treatment.	Radium	102-104	nucleophosmin 1	Homo sapiens	47-60
15589822-3	2004	It seems that there is a strong correlation of nucleophosmin/B23 and c-Myc expressions in cells under RA treatment.	Radium	102-104	nucleophosmin 1	Homo sapiens	61-64
15589822-3	2004	It seems that there is a strong correlation of nucleophosmin/B23 and c-Myc expressions in cells under RA treatment.	Radium	102-104	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
15466444-6	2004	Yet, the NO liberation in both LV and RA was accompanied by phosphorylation of eNOS(Ser1177) and Akt/PKB.	Radium	38-40	AKT serine/threonine kinase 1	Homo sapiens	97-104
15302580-4	2004	We have previously reported cooperative effects between BMP and RA downstream signaling involving Smad proteins and Runx2.	Radium	64-66	runt related transcription factor 2	Gallus gallus	116-121
15451478-7	2004	Finally, the RXR ligand 9-cis retinoic acid (9-cis RA) in combination with PPARgamma ligands greatly enhanced multiple myeloma cell killing.	Radium	51-53	retinoid X receptor alpha	Homo sapiens	13-16
15480382-4	2004	Naive CD4 (4+62+RA+ and 4+CCR7+RA+) and CD8 (8+CCR7+RA+) lymphocytes were lower in GH-deficient children ( P = .003; P = .007; and P = .02, respectively).	Radium	16-18	CD4 molecule	Homo sapiens	6-9
15480382-4	2004	Naive CD4 (4+62+RA+ and 4+CCR7+RA+) and CD8 (8+CCR7+RA+) lymphocytes were lower in GH-deficient children ( P = .003; P = .007; and P = .02, respectively).	Radium	31-33	CD4 molecule	Homo sapiens	6-9
15480382-4	2004	Naive CD4 (4+62+RA+ and 4+CCR7+RA+) and CD8 (8+CCR7+RA+) lymphocytes were lower in GH-deficient children ( P = .003; P = .007; and P = .02, respectively).	Radium	31-33	CD4 molecule	Homo sapiens	6-9
15325265-3	2004	We showed in Caco-2 cells that addition of RA significantly decreased 3MC-induced CYP1A1 expression by -55% for mRNA level and -30% for promoter and enzymatic activities.	Radium	43-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
15325265-6	2004	Using the corepressor inhibitor TSA, transfected-cells with SMRT cDNA, and coimmunoprecipitation experiments, we demonstrated that RA addition repressed AhR function through a marked AhR/SMRT physical interaction.	Radium	131-133	nuclear receptor corepressor 2	Homo sapiens	60-64
15325265-6	2004	Using the corepressor inhibitor TSA, transfected-cells with SMRT cDNA, and coimmunoprecipitation experiments, we demonstrated that RA addition repressed AhR function through a marked AhR/SMRT physical interaction.	Radium	131-133	aryl hydrocarbon receptor	Homo sapiens	153-156
15325265-6	2004	Using the corepressor inhibitor TSA, transfected-cells with SMRT cDNA, and coimmunoprecipitation experiments, we demonstrated that RA addition repressed AhR function through a marked AhR/SMRT physical interaction.	Radium	131-133	aryl hydrocarbon receptor	Homo sapiens	183-186
15325265-6	2004	Using the corepressor inhibitor TSA, transfected-cells with SMRT cDNA, and coimmunoprecipitation experiments, we demonstrated that RA addition repressed AhR function through a marked AhR/SMRT physical interaction.	Radium	131-133	nuclear receptor corepressor 2	Homo sapiens	187-191
15126348-3	2004	By substituting L11A, we obtained a dominant interfering galectin-1 that possessed normal carbohydrate-binding capacity but inhibited H-Ras GTP-loading and extracellular signal-regulated kinase activation, dislodged H-Ras(G12V) from the cell membrane, and attenuated H-Ras(G12V) fibroblast transformation and PC12-cell neurite outgrowth.	Radium	135-139	galectin 1	Homo sapiens	57-67
15234573-4	2004	These findings suggest that UF-1 cells, despite expressing mutant PML-RARalpha protein, can be induced by ATRA to undergo differentiation and apoptosis through RA-inducible mechanism(s), in which a proportion of apoptosis may occur independent of terminal differentiation.	Radium	70-72	PML nuclear body scaffold	Homo sapiens	66-69
15470882-9	2004	Ra values ranged from 0.02 microm to 0.15 microm and 0.03 microm to 4.40 microm for pH 7 and 2, respectively.	Radium	0-2	polyhomeotic homolog 2	Homo sapiens	84-94
15026310-5	2004	Simultaneous treatment with Ang-1 partially blocked RA induction of EC-MC malinteraction and reduction in blood vessel formation.	Radium	52-54	angiopoietin 1	Mus musculus	28-33
15103387-5	2004	Moreover, the importance of the blockage of t-RA signaling by the PML/RARalpha for the pathogenesis of APL is discussed, taking the relevance of the t-RA signaling pathway for the global hematopoiesis into account.	Radium	46-48	PML nuclear body scaffold	Homo sapiens	66-69
15103387-5	2004	Moreover, the importance of the blockage of t-RA signaling by the PML/RARalpha for the pathogenesis of APL is discussed, taking the relevance of the t-RA signaling pathway for the global hematopoiesis into account.	Radium	46-48	retinoic acid receptor alpha	Homo sapiens	70-78
15059967-0	2004	Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway.	Radium	103-106	heat shock protein family E (Hsp10) member 1	Homo sapiens	48-53
15103326-2	2004	Among these heterodimers, PPAR:RXR is considered an important signalling mediator of both PPAR ligands, such as fatty acids, and 9-cis retinoic acid (9-cis RA), an RXR ligand.	Radium	156-158	peroxisome proliferator activated receptor alpha	Mus musculus	26-30
15293312-7	2004	Up-regulation of phospholipase A2 and SMAD 4 indicate these genes are also involved in the response of cells to an Ra (5.8 microm) surface.	Radium	115-117	phospholipase A2 group IB	Rattus norvegicus	17-33
15293312-7	2004	Up-regulation of phospholipase A2 and SMAD 4 indicate these genes are also involved in the response of cells to an Ra (5.8 microm) surface.	Radium	115-117	SMAD family member 4	Rattus norvegicus	38-44
15287901-9	2004	Data indicate that: (i) positive cholinotrophic effects of NGF required activation of both TrkA and p75NTR receptors; (ii) cAMP/RA-evoked differentiation inhibited NGF effects mediated by TrkA receptors and activated its p75NTR-dependent suppressing influences and (iii) a differentiation-evoked decrease of mitochondrial acetyl-CoA and an elevation of mitochondrial Ca could augment impairment of cholinergic neurons by neurotoxic signals.	Radium	128-130	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	91-95
15287901-9	2004	Data indicate that: (i) positive cholinotrophic effects of NGF required activation of both TrkA and p75NTR receptors; (ii) cAMP/RA-evoked differentiation inhibited NGF effects mediated by TrkA receptors and activated its p75NTR-dependent suppressing influences and (iii) a differentiation-evoked decrease of mitochondrial acetyl-CoA and an elevation of mitochondrial Ca could augment impairment of cholinergic neurons by neurotoxic signals.	Radium	128-130	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	100-106
15287901-9	2004	Data indicate that: (i) positive cholinotrophic effects of NGF required activation of both TrkA and p75NTR receptors; (ii) cAMP/RA-evoked differentiation inhibited NGF effects mediated by TrkA receptors and activated its p75NTR-dependent suppressing influences and (iii) a differentiation-evoked decrease of mitochondrial acetyl-CoA and an elevation of mitochondrial Ca could augment impairment of cholinergic neurons by neurotoxic signals.	Radium	128-130	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	188-192
15287901-9	2004	Data indicate that: (i) positive cholinotrophic effects of NGF required activation of both TrkA and p75NTR receptors; (ii) cAMP/RA-evoked differentiation inhibited NGF effects mediated by TrkA receptors and activated its p75NTR-dependent suppressing influences and (iii) a differentiation-evoked decrease of mitochondrial acetyl-CoA and an elevation of mitochondrial Ca could augment impairment of cholinergic neurons by neurotoxic signals.	Radium	128-130	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	221-227
15200054-3	2004	We have now synthesized peptides corresponding to these four domains and find that all of them block Val 12-ras-p21-induced oocyte maturation.	Radium	107-111	H3 histone pseudogene 16	Homo sapiens	112-115
14720123-6	2004	After TGF-beta1 treatment of SNU16Ad cells on fibronectin, Tyr-416 phosphorylation of c-Src was increased, but Ras-GTP loading and ERK1/ERK2 (extracellular-signal-regulated kinases 1 and 2) activity were decreased, which showed a dependence on c-Src family kinase activity.	Radium	111-114	transforming growth factor beta 1	Homo sapiens	6-15
15110800-6	2004	To define the molecular mechanisms involved in IFN/retinoid (RA)-induced apoptosis we have employed a genetic approach and identified several critical genes.	Radium	61-63	interferon alpha 1	Homo sapiens	47-50
15134535-13	2004	Acyclic retinoid suppresses the phosphorylation of RXR alpha, restores its function in the presence of its endogenous ligand, 9-cis RA, and thereby induces apoptosis of the cancer cells.	Radium	132-134	retinoid X receptor alpha	Homo sapiens	51-60
14691453-2	2004	The tazarotene-induced gene 1 (TIG1), also known as retinoid acid (RA) receptor-responsive 1 gene was first identified as an RA-responsive gene and was shown to be downregulated in prostate cancer.	Radium	67-69	retinoic acid receptor responder 1	Homo sapiens	4-29
14691453-2	2004	The tazarotene-induced gene 1 (TIG1), also known as retinoid acid (RA) receptor-responsive 1 gene was first identified as an RA-responsive gene and was shown to be downregulated in prostate cancer.	Radium	67-69	retinoic acid receptor responder 1	Homo sapiens	31-35
15008977-5	2004	These data imply that RA, in combination with TNF-alpha, could up-regulate the expression of pIgR.	Radium	22-24	polymeric immunoglobulin receptor	Homo sapiens	93-97
15008977-6	2004	In addition, we hypothesize that up-regulation of pIgR by RA is controlled through the RAR-dependent signalling pathway and that it plays a role in enhancement of mucosal immunity.	Radium	58-60	polymeric immunoglobulin receptor	Homo sapiens	50-54
15008977-6	2004	In addition, we hypothesize that up-regulation of pIgR by RA is controlled through the RAR-dependent signalling pathway and that it plays a role in enhancement of mucosal immunity.	Radium	58-60	retinoic acid receptor alpha	Homo sapiens	87-90
14960230-3	2004	METHODS: After treated with all-trans-retinoic acid(RA) and telomerase antisense oligodeoxynucleotide (ASODN) respectively, the expression of CXCR4 mRNA and CXCR4 protein in NPC CNE1 and CNE2Z cells were determined by in situ hybridization and immunohistochemistry, respectively; the distribution of cell cycle was examined with flow cytometry and the proliferation of cells was identified by MTT method.	Radium	52-54	C-X-C motif chemokine receptor 4	Homo sapiens	142-147
14960230-3	2004	METHODS: After treated with all-trans-retinoic acid(RA) and telomerase antisense oligodeoxynucleotide (ASODN) respectively, the expression of CXCR4 mRNA and CXCR4 protein in NPC CNE1 and CNE2Z cells were determined by in situ hybridization and immunohistochemistry, respectively; the distribution of cell cycle was examined with flow cytometry and the proliferation of cells was identified by MTT method.	Radium	52-54	C-X-C motif chemokine receptor 4	Homo sapiens	157-162
17150542-1	2004	Transcription factor JDP2 served as a repressor of AP-1 and inhibited the transactivation of the c-jun gene by p300/ATF-2, by recruitment of histone deacetylase complex (HDAC3), thereby repressing the RA-induced transcription of the c-jun gene and then inhibiting the RA-mediated differentiation of F9 cells.	Radium	201-203	Jun dimerization protein 2	Homo sapiens	21-25
14532297-10	2004	CYP26C1 is not widely expressed in the adult but is inducible by RA in HPK1a, transformed human keratinocyte cell lines.	Radium	65-67	cytochrome P450 family 26 subfamily C member 1	Homo sapiens	0-7
14532297-11	2004	This third CYP26 member may play a specific role in catabolizing both all-trans and 9-cis isomers of RA.	Radium	101-103	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	11-16
15000491-8	2004	CONCLUSIONS: These results suggest that PAK1 is essential for the malignant growth of NF2-deficient cells, and that PAK1-blocking drugs could be potentially useful forthe treatment of neurofibromatosis types 2, in addition to Ras-induced cancers and neurofibromatosis type 1.	Radium	226-229	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	86-89
15000491-8	2004	CONCLUSIONS: These results suggest that PAK1 is essential for the malignant growth of NF2-deficient cells, and that PAK1-blocking drugs could be potentially useful forthe treatment of neurofibromatosis types 2, in addition to Ras-induced cancers and neurofibromatosis type 1.	Radium	226-229	p21 (RAC1) activated kinase 1	Homo sapiens	116-120
15700404-0	2004	Hyperdigraph-theoretic analysis of the EGFR signaling network: initial steps leading to GTP:Ras complex formation.	Radium	92-95	epidermal growth factor receptor	Homo sapiens	39-43
17150542-1	2004	Transcription factor JDP2 served as a repressor of AP-1 and inhibited the transactivation of the c-jun gene by p300/ATF-2, by recruitment of histone deacetylase complex (HDAC3), thereby repressing the RA-induced transcription of the c-jun gene and then inhibiting the RA-mediated differentiation of F9 cells.	Radium	201-203	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
17150542-1	2004	Transcription factor JDP2 served as a repressor of AP-1 and inhibited the transactivation of the c-jun gene by p300/ATF-2, by recruitment of histone deacetylase complex (HDAC3), thereby repressing the RA-induced transcription of the c-jun gene and then inhibiting the RA-mediated differentiation of F9 cells.	Radium	201-203	E1A binding protein p300	Homo sapiens	111-115
17150542-1	2004	Transcription factor JDP2 served as a repressor of AP-1 and inhibited the transactivation of the c-jun gene by p300/ATF-2, by recruitment of histone deacetylase complex (HDAC3), thereby repressing the RA-induced transcription of the c-jun gene and then inhibiting the RA-mediated differentiation of F9 cells.	Radium	201-203	activating transcription factor 2	Homo sapiens	116-121
17150542-1	2004	Transcription factor JDP2 served as a repressor of AP-1 and inhibited the transactivation of the c-jun gene by p300/ATF-2, by recruitment of histone deacetylase complex (HDAC3), thereby repressing the RA-induced transcription of the c-jun gene and then inhibiting the RA-mediated differentiation of F9 cells.	Radium	201-203	histone deacetylase 3	Homo sapiens	170-175
17150542-2	2004	These results suggest that HDAC3/JDP2 and p300/ATF-2 complex play a critical role in controlling the differentiation of F9 cells, in response to RA.	Radium	145-147	histone deacetylase 3	Homo sapiens	27-32
17150542-2	2004	These results suggest that HDAC3/JDP2 and p300/ATF-2 complex play a critical role in controlling the differentiation of F9 cells, in response to RA.	Radium	145-147	Jun dimerization protein 2	Homo sapiens	33-37
17150542-2	2004	These results suggest that HDAC3/JDP2 and p300/ATF-2 complex play a critical role in controlling the differentiation of F9 cells, in response to RA.	Radium	145-147	E1A binding protein p300	Homo sapiens	42-46
17150542-2	2004	These results suggest that HDAC3/JDP2 and p300/ATF-2 complex play a critical role in controlling the differentiation of F9 cells, in response to RA.	Radium	145-147	activating transcription factor 2	Homo sapiens	47-52
12959642-3	2003	In co-transfection experiments of HEK-293 (human embryonic kidney 293) cells, the -911/+29 human apoA-II promoter was transactivated strongly by RXRalpha/T(3)Rbeta heterodimers in the presence of RA (9- cis retinoic acid) or T(3) (tri-iodothyronine).	Radium	196-198	apolipoprotein A2	Homo sapiens	97-104
12959642-3	2003	In co-transfection experiments of HEK-293 (human embryonic kidney 293) cells, the -911/+29 human apoA-II promoter was transactivated strongly by RXRalpha/T(3)Rbeta heterodimers in the presence of RA (9- cis retinoic acid) or T(3) (tri-iodothyronine).	Radium	196-198	retinoid X receptor alpha	Homo sapiens	145-153
12750165-3	2003	Here we describe the properties of 2 CD8+ T-lymphocyte subsets, RA+CCR7-27+28+ and RA+CCR7-27+28-, in human peripheral blood.	Radium	64-66	CD8a molecule	Homo sapiens	37-40
14587026-4	2003	In both cell lines ATRA and 9-cis RA induced the most profound decreases in cyclin D1 and cdk2 expression and also mediated the largest growth inhibition.	Radium	21-23	cyclin D1	Homo sapiens	76-85
14587026-4	2003	In both cell lines ATRA and 9-cis RA induced the most profound decreases in cyclin D1 and cdk2 expression and also mediated the largest growth inhibition.	Radium	21-23	cyclin dependent kinase 2	Homo sapiens	90-94
12900402-6	2003	Truncation of the two carboxyl-terminal RA domains caused loss of responsiveness to H-Ras but not to Rho.	Radium	40-42	HRas proto-oncogene, GTPase	Homo sapiens	84-89
14692511-2	2003	Several of the compounds were weak inhibitors of the non-specific rat liver microsomal P450 enzymes and moderate inhibitors of the RA-induced enzymes in cultured human genital fibroblasts, where the RA-specific enzyme CYP26 is probably expressed.	Radium	131-133	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	218-223
14692511-2	2003	Several of the compounds were weak inhibitors of the non-specific rat liver microsomal P450 enzymes and moderate inhibitors of the RA-induced enzymes in cultured human genital fibroblasts, where the RA-specific enzyme CYP26 is probably expressed.	Radium	199-201	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	218-223
14653204-5	2003	On the contrary, two combination assays, "MMP-3 or CARF" and "MMP-3 or anti-CCP", showed the highest sensitivity(86.7%) for RA.	Radium	124-126	matrix metallopeptidase 3	Homo sapiens	42-47
14653204-5	2003	On the contrary, two combination assays, "MMP-3 or CARF" and "MMP-3 or anti-CCP", showed the highest sensitivity(86.7%) for RA.	Radium	124-126	calcium responsive transcription factor	Homo sapiens	51-56
14653204-5	2003	On the contrary, two combination assays, "MMP-3 or CARF" and "MMP-3 or anti-CCP", showed the highest sensitivity(86.7%) for RA.	Radium	124-126	matrix metallopeptidase 3	Homo sapiens	62-67
12941612-8	2003	Simultaneous addition of troglitazone and 9-cis RA enhanced both activation of PPARgamma/RXRalpha and growth inhibition in several types of cancer cells.	Radium	48-50	peroxisome proliferator activated receptor gamma	Homo sapiens	79-88
12941612-8	2003	Simultaneous addition of troglitazone and 9-cis RA enhanced both activation of PPARgamma/RXRalpha and growth inhibition in several types of cancer cells.	Radium	48-50	retinoid X receptor alpha	Homo sapiens	89-97
14649406-1	2003	Effects of two natural (retinol and retinoic acid, RA) and one synthetic N-(4-hydroxyphenyl) retinamide (4-HPR) retinoids on proliferation and expression of urokinase-plasminogen activator (u-PA) by bovine mammary epithelial cells were examined.	Radium	51-53	plasminogen activator, urokinase	Bos taurus	157-188
14649406-13	2003	RA at 1 microM inhibited (P<0.05) insulin or IGF-I-induced cell proliferation but had no effect (P>0.05) on u-PA mRNA levels or u-PA activity.	Radium	0-2	IGFI	Bos taurus	48-53
12895292-1	2003	For better understanding of functions of the Calcyclin Binding Protein (CacyBP) and exploring its possible roles in neuronal differentiation, the subcellular localization of human CacyBP was examined in retinoic acid(RA)-induced and uninduced neuroblastoma SH-SY5Y cells.	Radium	217-219	calcyclin binding protein	Homo sapiens	72-78
12788561-4	2003	The HABP immunosensor was prepared by covalently coupling Ra-HABP on an amine-self-assembled gold surface with glutaraldehyde.	Radium	58-60	hyaluronan binding protein 2	Homo sapiens	4-8
12788561-4	2003	The HABP immunosensor was prepared by covalently coupling Ra-HABP on an amine-self-assembled gold surface with glutaraldehyde.	Radium	58-60	hyaluronan binding protein 2	Homo sapiens	61-65
14612842-6	2003	RESULTS: RA after PTA was possible in all cases.	Radium	9-11	pre T cell antigen receptor alpha	Homo sapiens	18-21
14658285-3	2003	On the contrary, there were surprising differences in behavior of androgen-receptor system: the number of androgen-receptor sites in cytosol was increased significantly on 1st day after exposure (114%); on 10th day concentration of RA was quite oppositely 1.68-fold reduced in relation to the control; through 1-month after exposure the rising of [RA] (123%) was registered; however, to 3-month term the significant fall (1.42 times) of the RA contents in testicular cytosol persisted.	Radium	232-234	androgen receptor	Rattus norvegicus	66-83
14658285-3	2003	On the contrary, there were surprising differences in behavior of androgen-receptor system: the number of androgen-receptor sites in cytosol was increased significantly on 1st day after exposure (114%); on 10th day concentration of RA was quite oppositely 1.68-fold reduced in relation to the control; through 1-month after exposure the rising of [RA] (123%) was registered; however, to 3-month term the significant fall (1.42 times) of the RA contents in testicular cytosol persisted.	Radium	232-234	androgen receptor	Rattus norvegicus	106-123
14658285-3	2003	On the contrary, there were surprising differences in behavior of androgen-receptor system: the number of androgen-receptor sites in cytosol was increased significantly on 1st day after exposure (114%); on 10th day concentration of RA was quite oppositely 1.68-fold reduced in relation to the control; through 1-month after exposure the rising of [RA] (123%) was registered; however, to 3-month term the significant fall (1.42 times) of the RA contents in testicular cytosol persisted.	Radium	348-350	androgen receptor	Rattus norvegicus	66-83
14658285-3	2003	On the contrary, there were surprising differences in behavior of androgen-receptor system: the number of androgen-receptor sites in cytosol was increased significantly on 1st day after exposure (114%); on 10th day concentration of RA was quite oppositely 1.68-fold reduced in relation to the control; through 1-month after exposure the rising of [RA] (123%) was registered; however, to 3-month term the significant fall (1.42 times) of the RA contents in testicular cytosol persisted.	Radium	348-350	androgen receptor	Rattus norvegicus	106-123
14658285-3	2003	On the contrary, there were surprising differences in behavior of androgen-receptor system: the number of androgen-receptor sites in cytosol was increased significantly on 1st day after exposure (114%); on 10th day concentration of RA was quite oppositely 1.68-fold reduced in relation to the control; through 1-month after exposure the rising of [RA] (123%) was registered; however, to 3-month term the significant fall (1.42 times) of the RA contents in testicular cytosol persisted.	Radium	348-350	androgen receptor	Rattus norvegicus	66-83
14658285-3	2003	On the contrary, there were surprising differences in behavior of androgen-receptor system: the number of androgen-receptor sites in cytosol was increased significantly on 1st day after exposure (114%); on 10th day concentration of RA was quite oppositely 1.68-fold reduced in relation to the control; through 1-month after exposure the rising of [RA] (123%) was registered; however, to 3-month term the significant fall (1.42 times) of the RA contents in testicular cytosol persisted.	Radium	348-350	androgen receptor	Rattus norvegicus	106-123
12889993-4	2003	It appeared that DQCARII*194/DRB1*0405/TNFa*117 was part of the extended haplotype predisposed to RA, whereas DRB1*0901/D6S273*128 contributed to susceptibility to RA to a lesser degree in Singaporean Chinese.	Radium	98-100	major histocompatibility complex, class II, DR beta 1	Homo sapiens	29-33
12889993-4	2003	It appeared that DQCARII*194/DRB1*0405/TNFa*117 was part of the extended haplotype predisposed to RA, whereas DRB1*0901/D6S273*128 contributed to susceptibility to RA to a lesser degree in Singaporean Chinese.	Radium	98-100	tumor necrosis factor	Homo sapiens	39-43
12889993-4	2003	It appeared that DQCARII*194/DRB1*0405/TNFa*117 was part of the extended haplotype predisposed to RA, whereas DRB1*0901/D6S273*128 contributed to susceptibility to RA to a lesser degree in Singaporean Chinese.	Radium	164-166	major histocompatibility complex, class II, DR beta 1	Homo sapiens	29-33
12889993-4	2003	It appeared that DQCARII*194/DRB1*0405/TNFa*117 was part of the extended haplotype predisposed to RA, whereas DRB1*0901/D6S273*128 contributed to susceptibility to RA to a lesser degree in Singaporean Chinese.	Radium	164-166	tumor necrosis factor	Homo sapiens	39-43
12895292-1	2003	For better understanding of functions of the Calcyclin Binding Protein (CacyBP) and exploring its possible roles in neuronal differentiation, the subcellular localization of human CacyBP was examined in retinoic acid(RA)-induced and uninduced neuroblastoma SH-SY5Y cells.	Radium	217-219	calcyclin binding protein	Homo sapiens	180-186
12895292-2	2003	Immunostaining indicated that CacyBP was present in the cytoplasm of uninduced SH-SY5Y cells, in which the resting Ca(2+) concentration was relatively lower than that of RA-induced cells.	Radium	170-172	calcyclin binding protein	Homo sapiens	30-36
12895292-6	2003	The translocation of CacyBP during the RA-induced differentiation of SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation.	Radium	39-41	calcyclin binding protein	Homo sapiens	21-27
12846418-3	2003	9-cis retinoic acid (9-cis RA), a ligand for both retinoic acid receptor (RAR)/retinoic X receptor (RXR) heterodimers as well as RXR/RXR homodimers, markedly induced NIS mRNA expression in MCF-7 breast cancer cells in a dose- and time-dependent fashion, with maximal levels occurring at 12 h. All-trans retinoic acid, ATRA, a RAR specific ligand had a similar potency.	Radium	27-29	retinoic acid receptor alpha	Homo sapiens	326-329
12846418-3	2003	9-cis retinoic acid (9-cis RA), a ligand for both retinoic acid receptor (RAR)/retinoic X receptor (RXR) heterodimers as well as RXR/RXR homodimers, markedly induced NIS mRNA expression in MCF-7 breast cancer cells in a dose- and time-dependent fashion, with maximal levels occurring at 12 h. All-trans retinoic acid, ATRA, a RAR specific ligand had a similar potency.	Radium	27-29	retinoic acid receptor alpha	Homo sapiens	50-72
12846418-3	2003	9-cis retinoic acid (9-cis RA), a ligand for both retinoic acid receptor (RAR)/retinoic X receptor (RXR) heterodimers as well as RXR/RXR homodimers, markedly induced NIS mRNA expression in MCF-7 breast cancer cells in a dose- and time-dependent fashion, with maximal levels occurring at 12 h. All-trans retinoic acid, ATRA, a RAR specific ligand had a similar potency.	Radium	27-29	retinoic acid receptor alpha	Homo sapiens	74-77
12810424-6	2003	Serum concentrations of TNFalpha were, within the RA group, inversely correlated with blood flow responses to both SNP (r=-0.67, p=0.002) and ACh (r=-0.64, p<0.005).	Radium	50-52	tumor necrosis factor	Homo sapiens	24-32
12802179-2	2003	Here we demonstrated that c-Jun N-terminal kinase 1 (JNK1) plays an essential role in RA-induced neurite outgrowth of SH-SY5Y cells.	Radium	86-88	mitogen-activated protein kinase 8	Homo sapiens	26-51
12702665-10	2003	In addition, we provide evidence that: (i) wildtype Raldh2 expression is restricted to the posteriormost pharyngeal mesoderm; (ii) endogenous RA response occurs in both the pharyngeal endoderm and mesoderm, and extends more rostrally than Raldh2 expression up to the 2nd arch; (iii) RA target genes (Hoxa1, Hoxb1) are downregulated in both the pharyngeal endoderm and mesoderm of mutant embryos.	Radium	142-144	aldehyde dehydrogenase 1 family member A2	Homo sapiens	52-58
12702665-10	2003	In addition, we provide evidence that: (i) wildtype Raldh2 expression is restricted to the posteriormost pharyngeal mesoderm; (ii) endogenous RA response occurs in both the pharyngeal endoderm and mesoderm, and extends more rostrally than Raldh2 expression up to the 2nd arch; (iii) RA target genes (Hoxa1, Hoxb1) are downregulated in both the pharyngeal endoderm and mesoderm of mutant embryos.	Radium	142-144	aldehyde dehydrogenase 1 family member A2	Homo sapiens	239-245
12702665-10	2003	In addition, we provide evidence that: (i) wildtype Raldh2 expression is restricted to the posteriormost pharyngeal mesoderm; (ii) endogenous RA response occurs in both the pharyngeal endoderm and mesoderm, and extends more rostrally than Raldh2 expression up to the 2nd arch; (iii) RA target genes (Hoxa1, Hoxb1) are downregulated in both the pharyngeal endoderm and mesoderm of mutant embryos.	Radium	142-144	homeobox A1	Homo sapiens	300-305
12702665-10	2003	In addition, we provide evidence that: (i) wildtype Raldh2 expression is restricted to the posteriormost pharyngeal mesoderm; (ii) endogenous RA response occurs in both the pharyngeal endoderm and mesoderm, and extends more rostrally than Raldh2 expression up to the 2nd arch; (iii) RA target genes (Hoxa1, Hoxb1) are downregulated in both the pharyngeal endoderm and mesoderm of mutant embryos.	Radium	142-144	homeobox B1	Homo sapiens	307-312
12702665-11	2003	Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm.	Radium	47-49	aldehyde dehydrogenase 1 family member A2	Homo sapiens	6-12
12846418-3	2003	9-cis retinoic acid (9-cis RA), a ligand for both retinoic acid receptor (RAR)/retinoic X receptor (RXR) heterodimers as well as RXR/RXR homodimers, markedly induced NIS mRNA expression in MCF-7 breast cancer cells in a dose- and time-dependent fashion, with maximal levels occurring at 12 h. All-trans retinoic acid, ATRA, a RAR specific ligand had a similar potency.	Radium	27-29	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	88-98
12846418-3	2003	9-cis retinoic acid (9-cis RA), a ligand for both retinoic acid receptor (RAR)/retinoic X receptor (RXR) heterodimers as well as RXR/RXR homodimers, markedly induced NIS mRNA expression in MCF-7 breast cancer cells in a dose- and time-dependent fashion, with maximal levels occurring at 12 h. All-trans retinoic acid, ATRA, a RAR specific ligand had a similar potency.	Radium	27-29	retinoid X receptor alpha	Homo sapiens	100-103
12802179-2	2003	Here we demonstrated that c-Jun N-terminal kinase 1 (JNK1) plays an essential role in RA-induced neurite outgrowth of SH-SY5Y cells.	Radium	86-88	mitogen-activated protein kinase 8	Homo sapiens	53-57
12802179-3	2003	Treatment of SH-SY5Y cells with RA induced a strong activation of JNK1 within 10 min, and the immediate increase of JNK1 activity returned to the basal level in an hour.	Radium	32-34	mitogen-activated protein kinase 8	Homo sapiens	66-70
12802179-3	2003	Treatment of SH-SY5Y cells with RA induced a strong activation of JNK1 within 10 min, and the immediate increase of JNK1 activity returned to the basal level in an hour.	Radium	32-34	mitogen-activated protein kinase 8	Homo sapiens	116-120
12802179-4	2003	The second surge of JNK1 activity was observed around 1 day after RA treatment, which coincided with the period of extensive neurite outgrowth.	Radium	66-68	mitogen-activated protein kinase 8	Homo sapiens	20-24
12802179-6	2003	In SH-SY5Y carrying a dominant negative form of SEK1, an upstream kinase of JNK1, both early and late inductions of JNK1 activity were repressed along with RA-induced neurite outgrowth.	Radium	156-158	mitogen-activated protein kinase kinase 4	Homo sapiens	48-52
12802179-6	2003	In SH-SY5Y carrying a dominant negative form of SEK1, an upstream kinase of JNK1, both early and late inductions of JNK1 activity were repressed along with RA-induced neurite outgrowth.	Radium	156-158	mitogen-activated protein kinase 8	Homo sapiens	76-80
12802179-7	2003	These results suggest that JNK1 plays an essential role in RA-induced neuronal differentiation of SH-SY5Y cells.	Radium	59-61	mitogen-activated protein kinase 8	Homo sapiens	27-31
12399463-8	2003	Betaglycan promoter activity was increased by RA and inhibited by the three isoforms of TGF-beta.	Radium	46-48	transforming growth factor, beta receptor III	Mus musculus	0-10
12894505-10	2003	The addition of ET-18-OCH3 to the cytosolic fraction isolated from untreated cells also reduced the binding of Raf to activated GST-Ras-GTP-gamma-S.	Radium	132-135	zinc fingers and homeoboxes 2	Homo sapiens	111-114
12595592-5	2003	VEGF protein declined in the experimental groups with a significant reduction in the recovery group compared with the RA group (p < or = 0.05).	Radium	118-120	vascular endothelial growth factor A	Homo sapiens	0-4
12595592-7	2003	Lavage fluid VEGF protein and lung capillary leak rose significantly with O(2) and O(2) + NO compared with RA, but endostatin was unchanged.	Radium	107-109	vascular endothelial growth factor A	Homo sapiens	13-17
12520523-2	2003	We identified VDR- and retinoid X receptor (RXR)-interacting LXXLL peptides using a mammalian two-hybrid system and examined whether these molecules could block vitamin D and 9-cis retinoic acid (9-cis RA) response.	Radium	202-204	retinoid X receptor alpha	Homo sapiens	44-47
12846056-5	2003	RESULTS: In the non-refractory RA group the CCR5 delta 32 gene frequency was 0.019 and the following genotype frequencies were observed: CCR5/CCR5 = 98.0%, CCR5/CCR5 delta 32 = 1.9% and CCR5 delta 32/CCR5 delta = 1.0%.	Radium	31-33	C-C motif chemokine receptor 5	Homo sapiens	44-48
12846056-6	2003	In the refractory RA group the CCR5 delta 32 gene frequency was 0.025 and the genotype distribution was similar to that in the non-refractory RA group.	Radium	18-20	C-C motif chemokine receptor 5	Homo sapiens	31-35
12846056-9	2003	We observed a significant increase in the frequency of the DRB1*07 allele in severe RA patients in relation to the non-severe RA group (p = 0.02, OR = 5.65, 95% CI = 0.95-43.05).	Radium	84-86	major histocompatibility complex, class II, DR beta 1	Homo sapiens	59-63
12846056-9	2003	We observed a significant increase in the frequency of the DRB1*07 allele in severe RA patients in relation to the non-severe RA group (p = 0.02, OR = 5.65, 95% CI = 0.95-43.05).	Radium	126-128	major histocompatibility complex, class II, DR beta 1	Homo sapiens	59-63
12675130-10	2003	The SSR2(a) receptor ligand SS was found to be present not only in the cytoplasm but also in the nucleus, and more strongly so after RA treatment.	Radium	133-135	signal sequence receptor subunit 2	Homo sapiens	4-8
12589759-3	2003	In contrast, rat amylin (rA) which differs from hA by only six amino acid residues in the central region of the peptide, residues 18-29, does not form fibrils and is not cytotoxic.	Radium	25-27	islet amyloid polypeptide	Rattus norvegicus	17-23
12480945-8	2003	In addition, RXR alpha was found to bind FOG-2, in a 9-cis-RA-dependent manner.	Radium	59-61	retinoid X receptor alpha	Rattus norvegicus	13-22
12480945-8	2003	In addition, RXR alpha was found to bind FOG-2, in a 9-cis-RA-dependent manner.	Radium	59-61	zinc finger protein, multitype 2	Rattus norvegicus	41-46
12574792-4	2003	However, ET-1 and VP production could be increased by RA system-dependent stimulation, continually promoted by paracrine stimulation and sustained by neointimal growth.	Radium	54-56	endothelin 1	Homo sapiens	9-20
12510353-3	2002	Assessment of RA before and after LCAP showed a substantial and rapid improvement in tender joints counts, swollen joint counts, and patient"s and physician"s assessments.	Radium	14-16	L1CAM antisense RNA 1	Homo sapiens	34-38
12510353-4	2002	Careful analysis indicated that 64-80% of patients with RA showed > or = 20% improvement following LCAP therapy.	Radium	56-58	L1CAM antisense RNA 1	Homo sapiens	102-106
12510353-5	2002	Furthermore, we investigated the clinical evaluation of LCAP for RA over the 3 year-study period.	Radium	65-67	L1CAM antisense RNA 1	Homo sapiens	56-60
12510364-4	2002	Various clinical studies have confirmed that the efficacy of COX-2 inhibitors for RA is similar to that of conventional NSAIDs, but they cause fewer severe gastrointestinal disorders.	Radium	82-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
12372776-5	2002	In LS rats, in both plasma and renal cortex, the increase in RA was associated with an increase in ANG I and ANG II levels compared with NS rats, but intrarenal ANG II levels increased more than ANG I levels.	Radium	61-63	angiogenin	Rattus norvegicus	99-102
12435367-11	2002	To further define sites of RA synthesis in antler, we immunolocalised retinaldehyde dehydrogenase type 2 (RALDH-2), a major retinoic acid-generating enzyme.	Radium	27-29	aldehyde dehydrogenase 1 family member A2	Homo sapiens	106-113
12435367-14	2002	The effect of RA on antler cell differentiation was studied in vitro; all-trans-RA inhibits expression of the chondrocyte phenotype, an effect that is blocked by addition of the RAR antagonist Ro41-5253.	Radium	14-16	retinoic acid receptor alpha	Homo sapiens	178-181
12435367-14	2002	The effect of RA on antler cell differentiation was studied in vitro; all-trans-RA inhibits expression of the chondrocyte phenotype, an effect that is blocked by addition of the RAR antagonist Ro41-5253.	Radium	80-82	retinoic acid receptor alpha	Homo sapiens	178-181
12372776-5	2002	In LS rats, in both plasma and renal cortex, the increase in RA was associated with an increase in ANG I and ANG II levels compared with NS rats, but intrarenal ANG II levels increased more than ANG I levels.	Radium	61-63	angiogenin	Rattus norvegicus	109-112
12372776-5	2002	In LS rats, in both plasma and renal cortex, the increase in RA was associated with an increase in ANG I and ANG II levels compared with NS rats, but intrarenal ANG II levels increased more than ANG I levels.	Radium	61-63	angiotensinogen	Rattus norvegicus	109-115
12372776-5	2002	In LS rats, in both plasma and renal cortex, the increase in RA was associated with an increase in ANG I and ANG II levels compared with NS rats, but intrarenal ANG II levels increased more than ANG I levels.	Radium	61-63	angiogenin	Rattus norvegicus	109-112
12372776-6	2002	In NS+Los rats, the increase in RA in plasma was followed by a marked increase in plasma ANG I and ANG II levels compared with NS rats whereas in the kidney the increase of renal RA was followed by a decrease of the levels of these peptides.	Radium	32-34	angiogenin	Rattus norvegicus	89-92
12372776-6	2002	In NS+Los rats, the increase in RA in plasma was followed by a marked increase in plasma ANG I and ANG II levels compared with NS rats whereas in the kidney the increase of renal RA was followed by a decrease of the levels of these peptides.	Radium	32-34	angiogenin	Rattus norvegicus	99-102
12147251-4	2002	Using MG-63 human osteosarcoma cells, we demonstrated that both TIMP-1 and TIMP-2 caused an increase in the Ras-GTP level in a dose-dependent manner.	Radium	108-112	TIMP metallopeptidase inhibitor 1	Homo sapiens	64-70
12242722-7	2002	Our analysis demonstrates that the early Cdx1 expression is regulated through the caudalizing Wnt/beta-catenin and RA activities.	Radium	115-117	caudal type homeobox 1	Mus musculus	41-45
12163600-6	2002	The vIRF1 protein deregulates GRIM19-induced apoptosis in the presence of IFN/all-trans-retinoic acid (RA) and inhibits IFN/RA-induced cell death.	Radium	103-105	K9	Human gammaherpesvirus 8	4-9
12163600-6	2002	The vIRF1 protein deregulates GRIM19-induced apoptosis in the presence of IFN/all-trans-retinoic acid (RA) and inhibits IFN/RA-induced cell death.	Radium	103-105	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	30-36
12163600-6	2002	The vIRF1 protein deregulates GRIM19-induced apoptosis in the presence of IFN/all-trans-retinoic acid (RA) and inhibits IFN/RA-induced cell death.	Radium	124-126	K9	Human gammaherpesvirus 8	4-9
12163600-6	2002	The vIRF1 protein deregulates GRIM19-induced apoptosis in the presence of IFN/all-trans-retinoic acid (RA) and inhibits IFN/RA-induced cell death.	Radium	124-126	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	30-36
12163600-6	2002	The vIRF1 protein deregulates GRIM19-induced apoptosis in the presence of IFN/all-trans-retinoic acid (RA) and inhibits IFN/RA-induced cell death.	Radium	124-126	interferon alpha 1	Homo sapiens	120-123
12147251-4	2002	Using MG-63 human osteosarcoma cells, we demonstrated that both TIMP-1 and TIMP-2 caused an increase in the Ras-GTP level in a dose-dependent manner.	Radium	108-112	TIMP metallopeptidase inhibitor 2	Homo sapiens	75-81
12032842-1	2002	v-H-ras transformed C2C12 (C2Ras) myoblasts, overexpressing p21-Ras protein in the Ras-GTP active form, showed a differentiation-defective phenotype when cultured in low serum as compared with C2C12 myoblasts.	Radium	29-32	HRas proto-oncogene, GTPase	Homo sapiens	60-67
12083777-6	2002	The autoantibody to PARP was infrequently detected in the serum of patients with RA (1/50).	Radium	81-83	poly(ADP-ribose) polymerase 1	Homo sapiens	20-24
11934895-5	2002	In transient transfection assay, expression of COUP-TF strongly inhibited tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 transactivation activity and transactivation of c-Jun/c-Fos in both a trans-RA-dependent and -independent manner.	Radium	215-217	nuclear receptor subfamily 2 group F member 1	Homo sapiens	47-54
11934895-8	2002	The effect of COUP-TF in enhancing the trans-RA-induced antagonism of AP-1 activity required expression of retinoic acid receptors (RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells, which do not express RARalpha and RARbeta, failed to restore trans-RA-induced AP-1 repression.	Radium	45-47	nuclear receptor subfamily 2 group F member 1	Homo sapiens	14-21
11934895-8	2002	The effect of COUP-TF in enhancing the trans-RA-induced antagonism of AP-1 activity required expression of retinoic acid receptors (RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells, which do not express RARalpha and RARbeta, failed to restore trans-RA-induced AP-1 repression.	Radium	45-47	nuclear receptor subfamily 2 group F member 1	Homo sapiens	166-173
11934895-8	2002	The effect of COUP-TF in enhancing the trans-RA-induced antagonism of AP-1 activity required expression of retinoic acid receptors (RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells, which do not express RARalpha and RARbeta, failed to restore trans-RA-induced AP-1 repression.	Radium	45-47	nuclear receptor subfamily 2 group F member 1	Homo sapiens	166-173
11934895-8	2002	The effect of COUP-TF in enhancing the trans-RA-induced antagonism of AP-1 activity required expression of retinoic acid receptors (RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells, which do not express RARalpha and RARbeta, failed to restore trans-RA-induced AP-1 repression.	Radium	45-47	retinoic acid receptor alpha	Homo sapiens	245-253
11934895-8	2002	The effect of COUP-TF in enhancing the trans-RA-induced antagonism of AP-1 activity required expression of retinoic acid receptors (RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells, which do not express RARalpha and RARbeta, failed to restore trans-RA-induced AP-1 repression.	Radium	45-47	retinoic acid receptor beta	Homo sapiens	258-265
12223961-1	2002	The active metabolite of vitamin A (retinoic acid, RA) acts through the nuclear receptors RARalpha, beta and gamma and RXRalpha, beta and gamma.	Radium	51-53	retinoic acid receptor, alpha	Mus musculus	90-98
12223961-1	2002	The active metabolite of vitamin A (retinoic acid, RA) acts through the nuclear receptors RARalpha, beta and gamma and RXRalpha, beta and gamma.	Radium	51-53	retinoid X receptor alpha	Mus musculus	119-127
12223961-11	2002	A similar genetic approach applied to the RARgamma locus demonstrated that topical administration of RA on the skin activates RARgamma/RXR heterodimers in suprabasal cells, and induces expression of a paracrine growth factor (HB-EGF) in these cells which, in turn, stimulates the proliferation of basal cells.	Radium	42-44	retinoic acid receptor, gamma	Mus musculus	126-134
11640910-4	2001	In addition, the complete RA pathway and its terminal fields in the respiratory-vocal nuclei of the brainstem were strongly PV-positive.	Radium	26-28	parvalbumin alpha	Serinus canaria	124-126
11939783-6	2002	However, the saturated diterpenoid phytanic acid (PA) and docosahexaenoic acid, which have been recently shown to activate the nuclear receptor, RXR, competed with 9-cis-RA labeling, showing high affinity for the 9-cis-RA binding site.	Radium	170-172	retinoid X receptor alpha	Homo sapiens	145-148
11939783-6	2002	However, the saturated diterpenoid phytanic acid (PA) and docosahexaenoic acid, which have been recently shown to activate the nuclear receptor, RXR, competed with 9-cis-RA labeling, showing high affinity for the 9-cis-RA binding site.	Radium	219-221	retinoid X receptor alpha	Homo sapiens	145-148
11994141-4	2002	In RA-treated normal and non-lesional skin, the mRNA expression of CRBPI was unaltered while that of CRABPI and CRABPII was reduced by approximately 80% and increased approximately 5-fold, respectively, as compared to vehicle-treated skin.	Radium	3-5	retinol binding protein 1	Homo sapiens	67-72
11994141-4	2002	In RA-treated normal and non-lesional skin, the mRNA expression of CRBPI was unaltered while that of CRABPI and CRABPII was reduced by approximately 80% and increased approximately 5-fold, respectively, as compared to vehicle-treated skin.	Radium	3-5	retinol binding protein 1	Homo sapiens	101-107
11994141-4	2002	In RA-treated normal and non-lesional skin, the mRNA expression of CRBPI was unaltered while that of CRABPI and CRABPII was reduced by approximately 80% and increased approximately 5-fold, respectively, as compared to vehicle-treated skin.	Radium	3-5	cellular retinoic acid binding protein 2	Homo sapiens	112-119
11994141-5	2002	In contrast, lesional skin exposed to RA showed an almost 90% increase in CRBPI transcripts but unaltered expression of CRABPI and CRABPII, yet, the mRNA expression of several inflammatory mediators, e.g. inducible nitric oxide synthase, interferon-gamma and interleukin-1beta, was clearly reduced.	Radium	38-40	retinol binding protein 1	Homo sapiens	74-79
11994141-5	2002	In contrast, lesional skin exposed to RA showed an almost 90% increase in CRBPI transcripts but unaltered expression of CRABPI and CRABPII, yet, the mRNA expression of several inflammatory mediators, e.g. inducible nitric oxide synthase, interferon-gamma and interleukin-1beta, was clearly reduced.	Radium	38-40	interferon gamma	Homo sapiens	238-254
11994141-5	2002	In contrast, lesional skin exposed to RA showed an almost 90% increase in CRBPI transcripts but unaltered expression of CRABPI and CRABPII, yet, the mRNA expression of several inflammatory mediators, e.g. inducible nitric oxide synthase, interferon-gamma and interleukin-1beta, was clearly reduced.	Radium	38-40	interleukin 1 beta	Homo sapiens	259-276
11994141-7	2002	RA treatment induced CRABPII protein expression in normal and non-lesional skin, to similar levels as in untreated lesions.	Radium	0-2	cellular retinoic acid binding protein 2	Homo sapiens	21-28
11895107-5	2002	Of the G1 cyclins tested, troglitazone specifically reduced the expression of cyclin D1 mRNA and the corresponding protein and this effect was also additive with 9-cis RA.	Radium	168-170	cyclin D1	Homo sapiens	78-87
11804877-1	2002	In this study, we examined the effects of all trans-retinoic acid (at-RA) on the vascular endothelial growth factor (VEGF) expression in human bronchioloalveolar carcinoma NCI-H322 cells to evaluate the potential of at-RA to affect tumor progression.	Radium	70-72	vascular endothelial growth factor A	Homo sapiens	81-115
11804877-1	2002	In this study, we examined the effects of all trans-retinoic acid (at-RA) on the vascular endothelial growth factor (VEGF) expression in human bronchioloalveolar carcinoma NCI-H322 cells to evaluate the potential of at-RA to affect tumor progression.	Radium	70-72	vascular endothelial growth factor A	Homo sapiens	117-121
11429697-7	2001	The latter cells also displayed both immunocytochemical and biochemical evidence of translocation of cytochrome c into the cytosol following RA-treatment.	Radium	141-143	cytochrome c, somatic	Homo sapiens	101-113
11564604-9	2001	Further experiments with a mutant hRXR alpha (F313A) which elicits 9-cis RA-independent transactivation as a homodimer demonstrate that, when heterodimerized with VDR, this RXR mutant is incapable of activating the RXR-VDR heterocomplex in the absence of the VDR ligand.	Radium	73-75	retinoid X receptor alpha	Homo sapiens	34-44
11564604-9	2001	Further experiments with a mutant hRXR alpha (F313A) which elicits 9-cis RA-independent transactivation as a homodimer demonstrate that, when heterodimerized with VDR, this RXR mutant is incapable of activating the RXR-VDR heterocomplex in the absence of the VDR ligand.	Radium	73-75	vitamin D receptor	Homo sapiens	163-166
11564604-9	2001	Further experiments with a mutant hRXR alpha (F313A) which elicits 9-cis RA-independent transactivation as a homodimer demonstrate that, when heterodimerized with VDR, this RXR mutant is incapable of activating the RXR-VDR heterocomplex in the absence of the VDR ligand.	Radium	73-75	retinoid X receptor alpha	Homo sapiens	35-38
11564604-9	2001	Further experiments with a mutant hRXR alpha (F313A) which elicits 9-cis RA-independent transactivation as a homodimer demonstrate that, when heterodimerized with VDR, this RXR mutant is incapable of activating the RXR-VDR heterocomplex in the absence of the VDR ligand.	Radium	73-75	retinoid X receptor alpha	Homo sapiens	173-176
19003323-5	2001	Interestingly, treatment of the cells with induction medium in the presense of RA caused a 3- or 10-fold higher in ALP activity respectively as compared to those treated with RA or the induction medium alone.	Radium	79-81	alopecia, recessive	Mus musculus	115-118
19003323-5	2001	Interestingly, treatment of the cells with induction medium in the presense of RA caused a 3- or 10-fold higher in ALP activity respectively as compared to those treated with RA or the induction medium alone.	Radium	175-177	alopecia, recessive	Mus musculus	115-118
11304536-5	2001	Indirect immunofluorescence studies with anti-SMRTe antibody reveal discrete cytoplasmic and nuclear speckles, which contain RARalpha in an RA-sensitive manner.	Radium	125-127	nuclear receptor corepressor 2	Homo sapiens	46-51
11694593-7	2001	TNF-alpha, sphingomyelinase, and C(2)-ceramide translocated Cdc42, Rac, and RhoA to membranes, and stimulated p21-activated protein kinase downstream of Ras-GTP, PI 3-K, and SK.	Radium	153-156	tumor necrosis factor	Homo sapiens	0-9
11694593-7	2001	TNF-alpha, sphingomyelinase, and C(2)-ceramide translocated Cdc42, Rac, and RhoA to membranes, and stimulated p21-activated protein kinase downstream of Ras-GTP, PI 3-K, and SK.	Radium	153-156	cell division cycle 42	Homo sapiens	60-65
11694593-7	2001	TNF-alpha, sphingomyelinase, and C(2)-ceramide translocated Cdc42, Rac, and RhoA to membranes, and stimulated p21-activated protein kinase downstream of Ras-GTP, PI 3-K, and SK.	Radium	153-156	AKT serine/threonine kinase 1	Homo sapiens	67-70
11694593-7	2001	TNF-alpha, sphingomyelinase, and C(2)-ceramide translocated Cdc42, Rac, and RhoA to membranes, and stimulated p21-activated protein kinase downstream of Ras-GTP, PI 3-K, and SK.	Radium	153-156	ras homolog family member A	Homo sapiens	76-80
11694593-7	2001	TNF-alpha, sphingomyelinase, and C(2)-ceramide translocated Cdc42, Rac, and RhoA to membranes, and stimulated p21-activated protein kinase downstream of Ras-GTP, PI 3-K, and SK.	Radium	153-156	H3 histone pseudogene 16	Homo sapiens	110-113
11728175-7	2001	Western blotting showed that 15d-PGJ2 enhanced the levels of PPAR gamma, C/EBP alpha and RXR alpha proteins, while IL-11 and 9-cis RA decreased the level of PPAR gamma protein, but not C/EBP alpha protein and vitamin K2 decreased the level of C/EBP alpha protein.	Radium	131-133	peroxisome proliferator activated receptor gamma	Mus musculus	157-167
11401893-8	2001	BALF concentrations of total protein, thrombin and soluble tissue factor were significantly increased in mice of [RA+40 ppm NO] and [RA+40 ppm NO+O(2)] groups compared with [RA] group.	Radium	133-135	coagulation factor III	Mus musculus	59-72
11401893-8	2001	BALF concentrations of total protein, thrombin and soluble tissue factor were significantly increased in mice of [RA+40 ppm NO] and [RA+40 ppm NO+O(2)] groups compared with [RA] group.	Radium	133-135	coagulation factor III	Mus musculus	59-72
11434680-2	2001	During retinoid acid (RA)- and dibutyryl cAMP (dbcAMP)-induced differentiation of the APL cells, there is a marked up-modulation of both the protein kinase A (PKA) and C (PKC) activities.	Radium	22-24	proline rich transmembrane protein 2	Homo sapiens	171-174
11534804-7	2001	CONCLUSIONS: The molecular event of how SCC9, SCC15 and SCC25 are inhibited by RA and how KB, OC1, OC2 and OECM1 are resistant to RA can be further explored on the basis of this study.	Radium	130-132	one cut homeobox 2	Homo sapiens	99-102
11314039-6	2001	Expression of AATYK was also up-regulated as a function of RA-induced neuronal differentiation of p19 embryonal carcinoma cells, supporting a role for this protein in mature neurons and neuronal differentiation.	Radium	59-61	apoptosis-associated tyrosine kinase	Mus musculus	14-19
11343416-6	2001	The aim of this study was to investigate the effect of RA on NOS2 activation in cultured cardiac microvascular endothelial cells (CMEC) and adult rat ventricular myocytes (ARVM).	Radium	55-57	nitric oxide synthase 2	Rattus norvegicus	61-65
11343416-13	2001	These results document for the first time an effect of RA on NOS2 activation in cardiac cells.	Radium	55-57	nitric oxide synthase 2	Rattus norvegicus	61-65
11278809-2	2001	We previously reported that all-trans-retinoic acid (t-RA) protected mesangial cells from H(2)O(2)-triggered apoptosis by suppressing the activator protein 1 (AP-1) pathway.	Radium	55-57	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-157
11278809-2	2001	We previously reported that all-trans-retinoic acid (t-RA) protected mesangial cells from H(2)O(2)-triggered apoptosis by suppressing the activator protein 1 (AP-1) pathway.	Radium	55-57	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-163
11278809-9	2001	RAR antagonist reversed the suppressive effect of t-RA on both c-fos and c-jun, whereas RXR antagonist reversed the effect of t-RA on c-fos but not c-jun.	Radium	0-2	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
11278809-9	2001	RAR antagonist reversed the suppressive effect of t-RA on both c-fos and c-jun, whereas RXR antagonist reversed the effect of t-RA on c-fos but not c-jun.	Radium	52-54	retinoic acid receptor alpha	Homo sapiens	0-3
11278809-9	2001	RAR antagonist reversed the suppressive effect of t-RA on both c-fos and c-jun, whereas RXR antagonist reversed the effect of t-RA on c-fos but not c-jun.	Radium	52-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
11278809-9	2001	RAR antagonist reversed the suppressive effect of t-RA on both c-fos and c-jun, whereas RXR antagonist reversed the effect of t-RA on c-fos but not c-jun.	Radium	52-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
11783369-2	2001	METHODS: Cell culture, Fluo-3 AM loading and laser scanning confocal microscope, flowcytometer(FCM) and western blot were employed to detect expression and regulation effect on signal transduction pathway of gap junction gene connexin Cx43 in HeLa cells by retinotic acid(RA).	Radium	272-274	gap junction protein alpha 1	Homo sapiens	235-239
11245923-1	2001	We previously demonstrated that all-trans-retinoic acid (all-trans-RA) regulates gonadotropin-releasing hormone (GnRH) release and gene expression in rat hypothalamic fragments and GT1-1 neuronal cells.	Radium	67-69	gonadotropin releasing hormone 1	Rattus norvegicus	81-111
11245923-1	2001	We previously demonstrated that all-trans-retinoic acid (all-trans-RA) regulates gonadotropin-releasing hormone (GnRH) release and gene expression in rat hypothalamic fragments and GT1-1 neuronal cells.	Radium	67-69	gonadotropin releasing hormone 1	Rattus norvegicus	113-117
11245923-3	2001	In the present study, we attempted to localize functional retinoic acid response elements (RAREs) within the all-trans-RA-responsive region of the rat GnRH gene.	Radium	91-93	gonadotropin releasing hormone 1	Rattus norvegicus	151-155
11245924-6	2001	Accordingly, GnRH mRNA levels were decreased by 9-cis-RA treatment in a similar dose- and time-related manner, indicating that mouse GnRH expression is also negatively regulated by 9-cis-RA.	Radium	53-56	gonadotropin releasing hormone 1	Mus musculus	13-17
11245924-6	2001	Accordingly, GnRH mRNA levels were decreased by 9-cis-RA treatment in a similar dose- and time-related manner, indicating that mouse GnRH expression is also negatively regulated by 9-cis-RA.	Radium	53-56	gonadotropin releasing hormone 1	Mus musculus	133-137
11245924-7	2001	Transient transfections of serial deletion constructs of the rat GnRH promoter revealed that the --230/--110 sequence of the rat GnRH promoter is responsible for 9-cis-RA-induced inhibition of GnRH transcription.	Radium	168-170	gonadotropin releasing hormone 1	Mus musculus	65-69
11245924-7	2001	Transient transfections of serial deletion constructs of the rat GnRH promoter revealed that the --230/--110 sequence of the rat GnRH promoter is responsible for 9-cis-RA-induced inhibition of GnRH transcription.	Radium	168-170	gonadotropin releasing hormone 1	Mus musculus	129-133
11245924-7	2001	Transient transfections of serial deletion constructs of the rat GnRH promoter revealed that the --230/--110 sequence of the rat GnRH promoter is responsible for 9-cis-RA-induced inhibition of GnRH transcription.	Radium	168-170	gonadotropin releasing hormone 1	Rattus norvegicus	129-133
11396094-2	2001	Analysis of the structural interactions between DR4 susceptibility molecules and T cells specific for the peptide-MHC complex suggests a mechanism for directed T-cell selection and amplification in which RA-associated genetic polymorphisms bias intermolecular recognition.	Radium	204-206	major histocompatibility complex, class II, DR beta 4	Homo sapiens	48-51
11314039-6	2001	Expression of AATYK was also up-regulated as a function of RA-induced neuronal differentiation of p19 embryonal carcinoma cells, supporting a role for this protein in mature neurons and neuronal differentiation.	Radium	59-61	interleukin 23, alpha subunit p19	Mus musculus	98-101
11233987-6	2001	Mutation of the C-terminal RS to RA, or deletion of SKY1, results in the cytoplasmic accumulation of Npl3p.	Radium	33-35	nucleosome assembly protein 1 like 3	Homo sapiens	101-106
11294499-6	2001	The highest correlation for the % decrease of glycerol Ra from baseline was found at 60 min (r = 0.96, p < 0.001) making this parameter a useful index for the antilipoytic insulin sensitivity.	Radium	55-57	insulin	Homo sapiens	175-182
11266607-2	2001	This report describes a novel photoaffinity-based binding assay involving competition between potential ligands of CRABP and [(3)H]atRA or [(3)H]-9-cis-RA for binding to the atRA-binding sites of CRABP I and II.	Radium	116-118	cellular retinoic acid binding protein 1	Homo sapiens	196-210
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	94-97
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	zinc finger and BTB domain containing 16	Homo sapiens	111-115
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	zinc finger and BTB domain containing 16	Homo sapiens	170-174
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	retinoic acid receptor alpha	Homo sapiens	175-183
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	PML nuclear body scaffold	Homo sapiens	188-191
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	retinoic acid receptor alpha	Homo sapiens	192-200
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	294-297
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	zinc finger and BTB domain containing 16	Homo sapiens	111-116
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	zinc finger and BTB domain containing 16	Homo sapiens	309-314
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	zinc finger and BTB domain containing 16	Homo sapiens	170-174
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	retinoic acid receptor alpha	Homo sapiens	192-200
11920278-7	2001	CONCLUSIONS: At least two different mechanisms responsible for the aberrant recruitment of HD-NCR complexes by PLZF# are regulating the different t-RA-sensitivity of the PLZF/RARalpha and PML/RARalpha positive APL blasts: one is related to the direct binding of the different members of the HD-NCR complex to PLZF#; the other is an enforcing effect of PLZF# on the affinity of the PLZF/RARalpha fusion protein to the HD-NCR complex.	Radium	148-150	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	294-297
11013254-6	2000	The localization of ALDH6 to the developing sensory neuroepithelia of the eye, nose, and ear and discreet sites within the CNS suggests a role for RA signaling during primary neurogenesis at these sites.	Radium	147-149	aldehyde dehydrogenase 1 family member A3	Gallus gallus	20-25
11107126-8	2000	Compared to parental lines, 4-HPR achieved 1-3 log greater cell kills in RA-resistant LHN 12X RR, LA-N-5 12X RR, KCNR 12X RR, and MYCN-transduced SMS-LHN or SK-N-RA.	Radium	73-75	haptoglobin-related protein	Homo sapiens	30-33
10993889-12	2000	Furthermore, exogenous CAR also reduced the at-RA response of the betaRAREx2-tk construct.	Radium	47-49	nuclear receptor subfamily 1 group I member 3	Homo sapiens	23-26
10993889-13	2000	Thus, CAR acts negatively on PB responsiveness mediated by the CYP2B2 PBRU just as it prevents maximal at-RA responsiveness mediated by betaRARE.	Radium	106-108	nuclear receptor subfamily 1 group I member 3	Homo sapiens	6-9
11107126-5	2000	Transient (KCNR 12 X RR, LA-N-5 12X RR) or sustained (LHN 12X RR) novel overexpression of c-myc was associated with RA resistance.	Radium	116-118	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	90-95
11819702-1	2000	AIM:To study the molecular mechanisms of retinoic acid (RA)on prolix-feration and expression of cyclin-dependent kinase inhibitors (CKI), i.e.p16, p21 and p27 in cultured rat hepatic stellate cells (HSC) stimulated with transforming growth factor beta 1 (TGF-beta1).METHODS:HSC were isolated from healthy rat livers and cultured.After stimulated with 1mg/L TGF-beta1, subcultured HSC were treated with or without 1nmol/L RA.	Radium	56-58	transforming growth factor, beta 1	Rattus norvegicus	220-253
11107126-7	2000	Both parental and RA-resistant lines showed 2-4 logs of cell kill in response to N-(4-hydroxyphenyl)retinamide (4- HPR, fenretinide).	Radium	18-20	haptoglobin-related protein	Homo sapiens	115-118
11819702-1	2000	AIM:To study the molecular mechanisms of retinoic acid (RA)on prolix-feration and expression of cyclin-dependent kinase inhibitors (CKI), i.e.p16, p21 and p27 in cultured rat hepatic stellate cells (HSC) stimulated with transforming growth factor beta 1 (TGF-beta1).METHODS:HSC were isolated from healthy rat livers and cultured.After stimulated with 1mg/L TGF-beta1, subcultured HSC were treated with or without 1nmol/L RA.	Radium	56-58	transforming growth factor, beta 1	Rattus norvegicus	255-264
11819702-1	2000	AIM:To study the molecular mechanisms of retinoic acid (RA)on prolix-feration and expression of cyclin-dependent kinase inhibitors (CKI), i.e.p16, p21 and p27 in cultured rat hepatic stellate cells (HSC) stimulated with transforming growth factor beta 1 (TGF-beta1).METHODS:HSC were isolated from healthy rat livers and cultured.After stimulated with 1mg/L TGF-beta1, subcultured HSC were treated with or without 1nmol/L RA.	Radium	56-58	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	142-145
11819702-1	2000	AIM:To study the molecular mechanisms of retinoic acid (RA)on prolix-feration and expression of cyclin-dependent kinase inhibitors (CKI), i.e.p16, p21 and p27 in cultured rat hepatic stellate cells (HSC) stimulated with transforming growth factor beta 1 (TGF-beta1).METHODS:HSC were isolated from healthy rat livers and cultured.After stimulated with 1mg/L TGF-beta1, subcultured HSC were treated with or without 1nmol/L RA.	Radium	56-58	transforming growth factor, beta 1	Rattus norvegicus	357-366
11819702-3	2000	In addition, RA increased the protein level of p16 (218.75%, P <0.05) and induced p21 protein expression; meanwhile, p27 was undetectable by ICC in both control and RA-treated HSC.	Radium	13-15	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	47-50
11819702-1	2000	AIM:To study the molecular mechanisms of retinoic acid (RA)on prolix-feration and expression of cyclin-dependent kinase inhibitors (CKI), i.e.p16, p21 and p27 in cultured rat hepatic stellate cells (HSC) stimulated with transforming growth factor beta 1 (TGF-beta1).METHODS:HSC were isolated from healthy rat livers and cultured.After stimulated with 1mg/L TGF-beta1, subcultured HSC were treated with or without 1nmol/L RA.	Radium	56-58	KRAS proto-oncogene, GTPase	Rattus norvegicus	147-150
11819702-3	2000	In addition, RA increased the protein level of p16 (218.75%, P <0.05) and induced p21 protein expression; meanwhile, p27 was undetectable by ICC in both control and RA-treated HSC.	Radium	13-15	KRAS proto-oncogene, GTPase	Rattus norvegicus	85-88
11819702-1	2000	AIM:To study the molecular mechanisms of retinoic acid (RA)on prolix-feration and expression of cyclin-dependent kinase inhibitors (CKI), i.e.p16, p21 and p27 in cultured rat hepatic stellate cells (HSC) stimulated with transforming growth factor beta 1 (TGF-beta1).METHODS:HSC were isolated from healthy rat livers and cultured.After stimulated with 1mg/L TGF-beta1, subcultured HSC were treated with or without 1nmol/L RA.	Radium	56-58	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	155-158
11819702-3	2000	In addition, RA increased the protein level of p16 (218.75%, P <0.05) and induced p21 protein expression; meanwhile, p27 was undetectable by ICC in both control and RA-treated HSC.	Radium	168-170	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	120-123
11819702-4	2000	However, RA had no influence on the mRNA levels of p16, p21 or p27 as determined by ISH.CONCLUSION:Up-regulation of p16 and p21 on post-transcriptional level may contribute, in part, to RA inhibition of TGF-beta 1-initiated rat HSC activation in vitro.	Radium	9-11	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	116-119
10934204-11	2000	C-terminally truncated MR-GEF, lacking the GEF catalytic domain, retained its ability to bind M-Ras-GTP, suggesting that the RA domain is important for this interaction.	Radium	125-127	Rap guanine nucleotide exchange factor 5	Homo sapiens	23-29
11034387-5	2000	Target engagement also rapidly activated Ras, detected as active Ras-GTP bound to GST-Raf-RBD, a GST fusion protein linked to the Raf protein fragment containing the Ras-GTP binding domain.	Radium	41-44	zinc fingers and homeoboxes 2	Homo sapiens	130-133
11054805-11	2000	Our data demonstrate that the expression of gangliosides in P19 cells during RA-induced neuronal differentiation resembles that of the in vivo development of the vertebrate brain, and hence validates it as an in vitro model for investigating the function of gangliosides in neuronal development.	Radium	77-79	l(1)20Ca	Drosophila melanogaster	60-63
11073069-9	2000	These immunocytochemical data suggest that the Hsp 25 molecule is involved in reinforcement of the cell layer following cell movement during odontogenesis and in the formation and maintenance of the ruffled border of RA.	Radium	217-219	heat shock protein family B (small) member 1	Rattus norvegicus	47-53
11054668-2	2000	Less percentages (4-20%) of nucleophosmin/B23 over-expressed (pCR3-B23) cells exhibited the morphological characteristic of apoptosis as compared with control vector-transfected (pCR3) cells (6-53%) during the 10 microM RA treatment for 1-4 days.	Radium	220-222	nucleophosmin 1	Homo sapiens	28-41
11054668-3	2000	In flow cytometry analysis, a block in the G1 phase was noted in all the pCR3-B23 and pCR3 cells after 2 days of 10 microM RA treatment and continued to be observed at all times measured up to 6 days.	Radium	123-125	nucleophosmin 1	Homo sapiens	78-81
11054668-4	2000	Smaller peaks of apoptotic cells with less than G1 DNA content were observed in pCR3-B23 as compared with pCR3 cells after 4-6 days of 10 microM RA treatment.	Radium	145-147	nucleophosmin 1	Homo sapiens	85-88
11054668-5	2000	As measured by expressions of differentiation markers and the functional assessment of the ability to reduce nitroblue-tetrazolium, our results further showed that over-expression of nucleophosmin/B23 decreased the response of the cells to RA-induced differentiation.	Radium	240-242	nucleophosmin 1	Homo sapiens	183-196
11054668-5	2000	As measured by expressions of differentiation markers and the functional assessment of the ability to reduce nitroblue-tetrazolium, our results further showed that over-expression of nucleophosmin/B23 decreased the response of the cells to RA-induced differentiation.	Radium	240-242	nucleophosmin 1	Homo sapiens	197-200
11054668-6	2000	Less cleavage of PARP and in vitro caspase-3 activity were observed in PCR3-B23 cells as compared with pCR3 cells treated with 10 microM RA for 3-4 days.	Radium	137-139	caspase 3	Homo sapiens	35-44
11054668-6	2000	Less cleavage of PARP and in vitro caspase-3 activity were observed in PCR3-B23 cells as compared with pCR3 cells treated with 10 microM RA for 3-4 days.	Radium	137-139	nucleophosmin 1	Homo sapiens	76-79
11054668-7	2000	IRF-1 was induced after 6 hr of 10 microM RA treatment in the pCR3-B23 and pCR3 cells.	Radium	42-44	interferon regulatory factor 1	Homo sapiens	0-5
11054668-7	2000	IRF-1 was induced after 6 hr of 10 microM RA treatment in the pCR3-B23 and pCR3 cells.	Radium	42-44	nucleophosmin 1	Homo sapiens	67-70
11054668-8	2000	Significantly more nucleophosmin/B23 was co-immunoprecipitated with IRF-1 from pCR3-B23 cells than from pCR3 cells during RA treatment (10 microM; 24 hr, 96 hr).	Radium	122-124	nucleophosmin 1	Homo sapiens	19-32
11054668-8	2000	Significantly more nucleophosmin/B23 was co-immunoprecipitated with IRF-1 from pCR3-B23 cells than from pCR3 cells during RA treatment (10 microM; 24 hr, 96 hr).	Radium	122-124	nucleophosmin 1	Homo sapiens	33-36
11054668-9	2000	The IRF-1 transcriptional activity was found to be attenuated in pCR3-B23 cells as compared with pCR3 cells during the treatment of cells with RA.	Radium	143-145	interferon regulatory factor 1	Homo sapiens	4-9
11054668-9	2000	The IRF-1 transcriptional activity was found to be attenuated in pCR3-B23 cells as compared with pCR3 cells during the treatment of cells with RA.	Radium	143-145	nucleophosmin 1	Homo sapiens	70-73
11054668-10	2000	Nucleophosmin/B23, through interacting with IRF-1, plays an important role in the control of the susceptibility of cells to RA-induced differentiation and apoptosis.	Radium	124-126	nucleophosmin 1	Homo sapiens	0-13
11054668-10	2000	Nucleophosmin/B23, through interacting with IRF-1, plays an important role in the control of the susceptibility of cells to RA-induced differentiation and apoptosis.	Radium	124-126	nucleophosmin 1	Homo sapiens	14-17
11054668-10	2000	Nucleophosmin/B23, through interacting with IRF-1, plays an important role in the control of the susceptibility of cells to RA-induced differentiation and apoptosis.	Radium	124-126	interferon regulatory factor 1	Homo sapiens	44-49
11034387-5	2000	Target engagement also rapidly activated Ras, detected as active Ras-GTP bound to GST-Raf-RBD, a GST fusion protein linked to the Raf protein fragment containing the Ras-GTP binding domain.	Radium	41-44	zinc fingers and homeoboxes 2	Homo sapiens	86-89
10900196-10	2000	Furthermore, compared with cells from wild type littermates, Ras-GTP was elevated in all mouse Nf1(-/-) Schwann cells but never in Nf1(-/-) mouse fibroblasts.	Radium	61-65	neurofibromin 1	Mus musculus	95-98
11374178-9	2000	The concentration and activity of PAI-1 in the plasma of RA were also much higher than those in the plasma of OA(P < 0.05 and P < 0.0001) and healthy subjects(P < 0.0001 and P < 0.001).	Radium	57-59	serpin family E member 1	Homo sapiens	34-39
11374178-10	2000	The concentration and activity of PAI-1 in SF and plasma of RA correlated positively.	Radium	60-62	serpin family E member 1	Homo sapiens	34-39
10906161-16	2000	Glomerular staining for platelet-derived growth factor B-chain was significantly reduced in anti-Thy1.1-treated nephritic rats in the presence of isotretinoin or all-trans-RA, compared with the vehicle-treated group (P < 0.001).	Radium	172-174	platelet derived growth factor subunit B	Rattus norvegicus	24-62
11221542-1	2000	The metabolism of 13-(CIS) in mouse skin in vivo which was treated with TPA (or vehicle) typically showed that the retinoid was oxidized to 4-hydroxy, 5,6-epoxy-13-CIS, 5,8-oxy-13-CIS and undergoes geometric isomerization to RA.	Radium	225-227	promotion susceptibility QTL 1	Mus musculus	72-75
12903442-5	2000	RESULTS: With VD3 or/and 9-cis-RA treatment, the expression of hsp90 beta gene was slightly increased.	Radium	31-33	heat shock protein 90 alpha family class B member 1	Homo sapiens	63-73
11055551-5	2000	Both all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9c-RA) induced RBP mRNA expression in a dose- and time-dependent manner.	Radium	33-35	retinol binding protein 4, plasma	Mus musculus	77-80
11055551-8	2000	Given the extent and temporal pattern of RBP induction, we suggest that the RA-mediated increase in liver RBP is part of a cellular protection mechanism.	Radium	76-78	retinol binding protein 4, plasma	Mus musculus	41-44
11055551-8	2000	Given the extent and temporal pattern of RBP induction, we suggest that the RA-mediated increase in liver RBP is part of a cellular protection mechanism.	Radium	76-78	retinol binding protein 4, plasma	Mus musculus	106-109
11055551-9	2000	Increased levels of RBP would facilitate sequestration and possibly cellular export of RA in cells receiving prolonged exposure to high levels of RA, thus minimizing toxicity.	Radium	87-89	retinol binding protein 4, plasma	Mus musculus	20-23
11055551-9	2000	Increased levels of RBP would facilitate sequestration and possibly cellular export of RA in cells receiving prolonged exposure to high levels of RA, thus minimizing toxicity.	Radium	146-148	retinol binding protein 4, plasma	Mus musculus	20-23
12539663-0	2000	[The quantitative analysis of cyclin D1 expression in RA-treated and non-RA-treated ectomesenchymal cells in vitro].	Radium	54-56	cyclin D1	Mus musculus	30-39
10873074-2	2000	We have previously demonstrated that RA down-modulates transforming growth factor (TGF)-alpha and epidermal growth factor receptor (EGFR) levels in head and neck squamous cell carcinoma by decreasing the transcription rate of these two genes.	Radium	37-39	transforming growth factor alpha	Homo sapiens	83-93
10873074-2	2000	We have previously demonstrated that RA down-modulates transforming growth factor (TGF)-alpha and epidermal growth factor receptor (EGFR) levels in head and neck squamous cell carcinoma by decreasing the transcription rate of these two genes.	Radium	37-39	epidermal growth factor receptor	Homo sapiens	98-130
10873074-2	2000	We have previously demonstrated that RA down-modulates transforming growth factor (TGF)-alpha and epidermal growth factor receptor (EGFR) levels in head and neck squamous cell carcinoma by decreasing the transcription rate of these two genes.	Radium	37-39	epidermal growth factor receptor	Homo sapiens	132-136
10873074-3	2000	Previous reports suggest that RA receptor (RAR)-beta levels are down-modulated in head and neck cancer and are restored by RA therapy.	Radium	30-32	retinoic acid receptor alpha	Homo sapiens	43-46
10873074-4	2000	Cellular RA-binding protein (CRABP)-II is up-regulated by RA and appears to modulate intracellular RA metabolism.	Radium	9-11	cellular retinoic acid binding protein 2	Homo sapiens	29-38
12539663-0	2000	[The quantitative analysis of cyclin D1 expression in RA-treated and non-RA-treated ectomesenchymal cells in vitro].	Radium	73-75	cyclin D1	Mus musculus	30-39
12539663-1	2000	OBJECTIVE: To elucidate the alteration of Cyclin D1 protein between RA-treated and the non-RA-treated ectomesenchymal cells in embryonic mice.	Radium	68-70	cyclin D1	Mus musculus	42-51
12539663-1	2000	OBJECTIVE: To elucidate the alteration of Cyclin D1 protein between RA-treated and the non-RA-treated ectomesenchymal cells in embryonic mice.	Radium	91-93	cyclin D1	Mus musculus	42-51
10807788-5	2000	Membranes from TCR-stimulated Jurkat T cells exhibited increased RasGRP and increased Ras-guanyl nucleotide association activity that was inhibited by antibodies directed against RasGRP.	Radium	65-68	RAS guanyl releasing protein 1	Homo sapiens	179-185
10734312-2	2000	Shc is believed to be regulated by a change in subcellular localization from the cytosol to the plasma membrane, where it recruits Grb-2/Sos complexes and hence permits juxtaposition of the guanine nucleotide exchange factor Sos to Ras, resulting in GDP/GTP exchange and Ras activation.	Radium	232-235	SHC adaptor protein 1	Homo sapiens	0-3
10779427-4	2000	The optimal concentration of RAs also reduced the histamine concentration in the cultured mast cells (3.00 +/- 0.47 pg per cell in SCF alone, 1.44 +/- 0.18 pg per cell in SCF+ATRA, and 1.41 +/- 0.10 pg per cell in SCF+9-cis RA).	Radium	29-31	KIT ligand	Homo sapiens	131-134
10779427-4	2000	The optimal concentration of RAs also reduced the histamine concentration in the cultured mast cells (3.00 +/- 0.47 pg per cell in SCF alone, 1.44 +/- 0.18 pg per cell in SCF+ATRA, and 1.41 +/- 0.10 pg per cell in SCF+9-cis RA).	Radium	29-31	KIT ligand	Homo sapiens	171-174
10779427-4	2000	The optimal concentration of RAs also reduced the histamine concentration in the cultured mast cells (3.00 +/- 0.47 pg per cell in SCF alone, 1.44 +/- 0.18 pg per cell in SCF+ATRA, and 1.41 +/- 0.10 pg per cell in SCF+9-cis RA).	Radium	29-31	KIT ligand	Homo sapiens	171-174
10779427-9	2000	These results suggest that RA inhibits SCF-dependent differentiation of human mast cell progenitors through a specific receptor.	Radium	27-29	KIT ligand	Homo sapiens	39-42
10884186-5	2000	Cell culture experiments in thyroid carcinoma lines show that RA treatment affects thyroid specific functions (type I 5"-deiodinase, sodium/iodide-symporter), cell-cell or cell-matrix interaction (intercellular adhesion molecule-1, E-cadherin), differentiation markers (alkaline phosphatase, CD97), growth, and tumorigenicity.	Radium	62-64	iodothyronine deiodinase 1	Homo sapiens	111-131
10884186-5	2000	Cell culture experiments in thyroid carcinoma lines show that RA treatment affects thyroid specific functions (type I 5"-deiodinase, sodium/iodide-symporter), cell-cell or cell-matrix interaction (intercellular adhesion molecule-1, E-cadherin), differentiation markers (alkaline phosphatase, CD97), growth, and tumorigenicity.	Radium	62-64	intercellular adhesion molecule 1	Homo sapiens	197-230
10884186-5	2000	Cell culture experiments in thyroid carcinoma lines show that RA treatment affects thyroid specific functions (type I 5"-deiodinase, sodium/iodide-symporter), cell-cell or cell-matrix interaction (intercellular adhesion molecule-1, E-cadherin), differentiation markers (alkaline phosphatase, CD97), growth, and tumorigenicity.	Radium	62-64	cadherin 1	Homo sapiens	232-242
10884186-5	2000	Cell culture experiments in thyroid carcinoma lines show that RA treatment affects thyroid specific functions (type I 5"-deiodinase, sodium/iodide-symporter), cell-cell or cell-matrix interaction (intercellular adhesion molecule-1, E-cadherin), differentiation markers (alkaline phosphatase, CD97), growth, and tumorigenicity.	Radium	62-64	adhesion G protein-coupled receptor E5	Homo sapiens	292-296
10734312-2	2000	Shc is believed to be regulated by a change in subcellular localization from the cytosol to the plasma membrane, where it recruits Grb-2/Sos complexes and hence permits juxtaposition of the guanine nucleotide exchange factor Sos to Ras, resulting in GDP/GTP exchange and Ras activation.	Radium	232-235	xylosyltransferase 2	Homo sapiens	225-228
10658829-7	2000	When compared to RA group, there was significant reduction in neutrophil CD18 and intracellular oxidant production in the RA+NO group, but lung MPO was unchanged.	Radium	17-19	integrin subunit beta 2	Homo sapiens	73-77
10997326-8	2000	We conclude that CD34 immunostaining in BMB is a useful tool for distinguishing RA from other anemias, assessing blast percentage in MDS cases, classifying them according to FAB, and following their evolution.	Radium	80-82	CD34 molecule	Homo sapiens	17-21
11261266-3	2000	Serum levels of soluble CD44 variant 5 (sCD44v5) were determined in 14 patients with erosive RA.	Radium	93-95	CD44 molecule (Indian blood group)	Homo sapiens	24-28
11219390-15	2000	Sequence analysis revealed 100% homology of all RA-derived PTEN fragments to those from normal SF as well as to the published GenBank sequence (accession number U93051).	Radium	48-50	phosphatase and tensin homolog	Homo sapiens	59-63
11219390-16	2000	However, in situ hybridization demonstrated considerable differences in the expression of PTEN mRNA within the lining and the sublining layers of RA synovial membranes.	Radium	146-148	phosphatase and tensin homolog	Homo sapiens	90-94
10658829-7	2000	When compared to RA group, there was significant reduction in neutrophil CD18 and intracellular oxidant production in the RA+NO group, but lung MPO was unchanged.	Radium	122-124	integrin subunit beta 2	Homo sapiens	73-77
10585721-1	1999	The human vitamin D receptor (VDR) and retinoid X receptor-alpha (RXRalpha) modulate gene activity by forming homodimeric or heterodimeric complexes with specific DNA sequences and interaction with other elements of the transcriptional apparatus in the presence of their known endogenous ligands 1alpha,25-dihydroxyvitamin D3 (1, 25-[OH]2D3) and 9-cis-retinoic acid (9-c-RA).	Radium	371-373	vitamin D receptor	Homo sapiens	10-28
11151091-3	2000	Independently, the TCFs and C/EBPbeta have been shown to interact with SRF and to respond to Ras-dependent signaling pathways that result in transactivation of the SRE.	Radium	93-96	CCAAT enhancer binding protein beta	Homo sapiens	28-37
11151091-4	2000	Due to these common observations, we addressed the possibility that C/EBPbeta and Elk-1 could both be necessary for Ras-stimulated transactivation of the SRE.	Radium	116-119	CCAAT enhancer binding protein beta	Homo sapiens	68-77
11151091-4	2000	Due to these common observations, we addressed the possibility that C/EBPbeta and Elk-1 could both be necessary for Ras-stimulated transactivation of the SRE.	Radium	116-119	ETS transcription factor ELK1	Homo sapiens	82-87
10813093-14	2000	In our recent paper (Bojkova et al., 2000) drinking of lower doses of Mel during the late afternoon and night prolonged the latency period and in combination with RA showed an oncostatic effect on mammary carcinogenesis induced by NMU.	Radium	163-165	neuromedin U	Rattus norvegicus	231-234
27414051-6	2000	When 35-week depleted mice were subsequently administrated RA for 28 days, the expression of RA nuclear receptors and tTG was significantly induced.	Radium	59-61	transglutaminase 2, C polypeptide	Mus musculus	118-121
10585721-1	1999	The human vitamin D receptor (VDR) and retinoid X receptor-alpha (RXRalpha) modulate gene activity by forming homodimeric or heterodimeric complexes with specific DNA sequences and interaction with other elements of the transcriptional apparatus in the presence of their known endogenous ligands 1alpha,25-dihydroxyvitamin D3 (1, 25-[OH]2D3) and 9-cis-retinoic acid (9-c-RA).	Radium	371-373	vitamin D receptor	Homo sapiens	30-33
10585721-1	1999	The human vitamin D receptor (VDR) and retinoid X receptor-alpha (RXRalpha) modulate gene activity by forming homodimeric or heterodimeric complexes with specific DNA sequences and interaction with other elements of the transcriptional apparatus in the presence of their known endogenous ligands 1alpha,25-dihydroxyvitamin D3 (1, 25-[OH]2D3) and 9-cis-retinoic acid (9-c-RA).	Radium	371-373	retinoid X receptor alpha	Homo sapiens	39-64
10585721-1	1999	The human vitamin D receptor (VDR) and retinoid X receptor-alpha (RXRalpha) modulate gene activity by forming homodimeric or heterodimeric complexes with specific DNA sequences and interaction with other elements of the transcriptional apparatus in the presence of their known endogenous ligands 1alpha,25-dihydroxyvitamin D3 (1, 25-[OH]2D3) and 9-cis-retinoic acid (9-c-RA).	Radium	371-373	retinoid X receptor alpha	Homo sapiens	66-74
10566635-3	1999	Beta-blockade also caused a greater fall in immunoreactive insulin (IRI) during exercise, which could, in turn, have increased Ra directly or via an increased glucagon/insulin ratio.	Radium	127-129	insulin	Homo sapiens	59-66
10548514-4	1999	The binding of this protein to poly(rA) or poly(rG) was inhibited by immunoprecipitable anti-lipocortin I (calpactin II) and anti-S100 protein antibodies, but not by an anti-Ig antibody.	Radium	36-38	annexin A1	Homo sapiens	107-119
10548514-4	1999	The binding of this protein to poly(rA) or poly(rG) was inhibited by immunoprecipitable anti-lipocortin I (calpactin II) and anti-S100 protein antibodies, but not by an anti-Ig antibody.	Radium	36-38	S100 calcium binding protein A1	Homo sapiens	130-134
10544841-9	1999	Similar levels of mRNA expression of MMP-1, MMP-3 and MMP-13 by the PBMC and SFMC in both RA groups were observed.	Radium	90-92	matrix metallopeptidase 1	Homo sapiens	37-42
10544841-9	1999	Similar levels of mRNA expression of MMP-1, MMP-3 and MMP-13 by the PBMC and SFMC in both RA groups were observed.	Radium	90-92	matrix metallopeptidase 13	Homo sapiens	54-60
10515686-2	1999	Binding of RA to type II human cellular RA binding proteins (CRABPII) has been investigated by NMR spectroscopy.	Radium	11-13	cellular retinoic acid binding protein 2	Homo sapiens	61-68
10397747-6	1999	Pharmacological doses of RA induced differentiation and inhibited proliferation of cells transformed with either of the APL fusion genes, including PLZF-RARalpha, whereas physiological retinoic acid concentrations were sufficient to reverse the phenotype of cells transformed with wild-type RARalpha.	Radium	25-27	zinc finger and BTB domain containing 16	Mus musculus	148-152
10400643-9	1999	We found that t-RA abrogated the H2O2-induced expression of c-fos/c-jun and activation of AP-1.	Radium	16-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-65
10400643-9	1999	We found that t-RA abrogated the H2O2-induced expression of c-fos/c-jun and activation of AP-1.	Radium	16-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
10400643-9	1999	We found that t-RA abrogated the H2O2-induced expression of c-fos/c-jun and activation of AP-1.	Radium	16-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
10397747-6	1999	Pharmacological doses of RA induced differentiation and inhibited proliferation of cells transformed with either of the APL fusion genes, including PLZF-RARalpha, whereas physiological retinoic acid concentrations were sufficient to reverse the phenotype of cells transformed with wild-type RARalpha.	Radium	25-27	retinoic acid receptor, alpha	Mus musculus	153-161
10397747-6	1999	Pharmacological doses of RA induced differentiation and inhibited proliferation of cells transformed with either of the APL fusion genes, including PLZF-RARalpha, whereas physiological retinoic acid concentrations were sufficient to reverse the phenotype of cells transformed with wild-type RARalpha.	Radium	25-27	retinoic acid receptor, alpha	Mus musculus	291-299
10473129-2	1999	Here we report that COUP-TF2, an orphan member of the nuclear receptor family which suppresses RA actions by forming heterodimers with RXR, shows a pattern of sagittal bands in developing mouse cerebellum.	Radium	95-97	nuclear receptor subfamily 2, group F, member 2	Mus musculus	20-28
10403834-2	1999	Western blot analysis revealed that a treatment with 1 microM 9-cis-retinoic acid (9-cis RA) for 24 h decreased RXRalpha protein level to 72 +/- 9 and 75 +/- 7% in HepG2 and JEG-3 cells, respectively, when the levels in the non-treated cells were expressed as 100%.	Radium	89-91	retinoid X receptor alpha	Homo sapiens	112-120
10403834-5	1999	It was thus demonstrated that 9-cis RA downregulates RXRalpha by increasing the turnover of the protein in the two cell lines.	Radium	36-38	retinoid X receptor alpha	Homo sapiens	53-61
10393558-6	1999	The IR0-containing reporter was induced by RA in COS-1 cells in the presence of exogenously provided RARalpha and RXRbeta.	Radium	43-45	retinoic acid receptor, alpha	Mus musculus	101-109
10393558-6	1999	The IR0-containing reporter was induced by RA in COS-1 cells in the presence of exogenously provided RARalpha and RXRbeta.	Radium	43-45	retinoid X receptor beta	Mus musculus	114-121
10393558-8	1999	RA responsiveness of this IR0 was further confirmed in P19 cells that expressed endogenous RARs and RXRs.	Radium	0-2	arginyl-tRNA synthetase	Mus musculus	91-95
10435617-6	1999	RA-induced IFN alpha seems to play a role in inhibition of NB4 cell growth but not in their differentiation.	Radium	0-2	interferon alpha 1	Homo sapiens	11-20
10435617-10	1999	Our results identify some defects linked to RA-resistance in APL and support the hypothesis that RA-induced Stat1 expression and IFN secretion may be one of the mechanisms mediating growth inhibition by RA.	Radium	44-46	signal transducer and activator of transcription 1	Homo sapiens	108-113
10435617-10	1999	Our results identify some defects linked to RA-resistance in APL and support the hypothesis that RA-induced Stat1 expression and IFN secretion may be one of the mechanisms mediating growth inhibition by RA.	Radium	44-46	interferon alpha 1	Homo sapiens	129-132
10435617-10	1999	Our results identify some defects linked to RA-resistance in APL and support the hypothesis that RA-induced Stat1 expression and IFN secretion may be one of the mechanisms mediating growth inhibition by RA.	Radium	97-99	signal transducer and activator of transcription 1	Homo sapiens	108-113
10435617-10	1999	Our results identify some defects linked to RA-resistance in APL and support the hypothesis that RA-induced Stat1 expression and IFN secretion may be one of the mechanisms mediating growth inhibition by RA.	Radium	97-99	interferon alpha 1	Homo sapiens	129-132
10453081-1	1999	The relationship between RA- or dbcaMP-mediated differentiation and subsequent apoptosis in HL-60 cells was assessed by modulating the levels of differentiation suppressing the activity of PKC and PKA with calphostin C or GF 109203X and H89, respectively.	Radium	25-27	proline rich transmembrane protein 2	Homo sapiens	189-192
10334923-3	1999	In this study, we showed that a single amino acid mutation in the N-terminal RA domain of AF-6 abolished the interaction of AF-6 with activated Ras and that the sites of this critical amino acid residue were similar to those for Raf-1 and RalGDS.	Radium	77-79	afadin, adherens junction formation factor	Rattus norvegicus	90-94
10334923-3	1999	In this study, we showed that a single amino acid mutation in the N-terminal RA domain of AF-6 abolished the interaction of AF-6 with activated Ras and that the sites of this critical amino acid residue were similar to those for Raf-1 and RalGDS.	Radium	77-79	afadin, adherens junction formation factor	Rattus norvegicus	124-128
10334923-3	1999	In this study, we showed that a single amino acid mutation in the N-terminal RA domain of AF-6 abolished the interaction of AF-6 with activated Ras and that the sites of this critical amino acid residue were similar to those for Raf-1 and RalGDS.	Radium	77-79	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	229-234
10334923-3	1999	In this study, we showed that a single amino acid mutation in the N-terminal RA domain of AF-6 abolished the interaction of AF-6 with activated Ras and that the sites of this critical amino acid residue were similar to those for Raf-1 and RalGDS.	Radium	77-79	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	239-245
10215633-8	1999	Vanadate, in the RA tissue, blocked both the appearance of iNOS mRNA and the induction of functional iNOS.	Radium	17-19	nitric oxide synthase 2	Rattus norvegicus	59-63
10215633-8	1999	Vanadate, in the RA tissue, blocked both the appearance of iNOS mRNA and the induction of functional iNOS.	Radium	17-19	nitric oxide synthase 2	Rattus norvegicus	101-105
10215633-9	1999	In RA tissue, but not in the CM, inhibitors of NF-kappaB activation blocked the appearance of both functional iNOS and iNOS mRNA.	Radium	3-5	nitric oxide synthase 2	Rattus norvegicus	119-123
10215633-9	1999	In RA tissue, but not in the CM, inhibitors of NF-kappaB activation blocked the appearance of both functional iNOS and iNOS mRNA.	Radium	3-5	nitric oxide synthase 2	Rattus norvegicus	110-114
10227945-11	1999	Similarly, RA resulted in significant increases in serum IL-6 as compared with AP and PC, whereas CD showed no significant difference: RA, 161.3 +/- 66.2* vs. 95.1 +/- 1 vs. AP, 10.6 +/- 5.3 vs. PC, undetectable; *p < 0.05.	Radium	11-13	interleukin 6	Mus musculus	57-61
10075925-4	1999	dnRARalpha formed heterodimers with endogenous retinoid X receptor-alpha (RXRalpha) over RA response elements in competition with remaining endogenous RARgamma-RXRalpha heterodimers, and dose-dependently impaired retinoid-dependent gene transcription.	Radium	2-4	retinoid X receptor alpha	Mus musculus	47-72
10205168-5	1999	Raf-1 that cannot interact with Ras-GTP is not phosphorylated, showing that phosphorylation is Ras dependent, presumably occurring at the plasma membrane.	Radium	32-35	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
10227945-9	1999	RESULTS: Gut-mucosal IL-6 in the RA group was significantly higher than in all other groups: RA, 1,354.5 +/- 117.9* vs. CD, 964.3 +/- 114.0 vs. AP, 960.2 +/- 86.2 vs. PC, 908.0 +/- 83.6; *p < 0.05.	Radium	33-35	interleukin 6	Mus musculus	21-25
10227945-9	1999	RESULTS: Gut-mucosal IL-6 in the RA group was significantly higher than in all other groups: RA, 1,354.5 +/- 117.9* vs. CD, 964.3 +/- 114.0 vs. AP, 960.2 +/- 86.2 vs. PC, 908.0 +/- 83.6; *p < 0.05.	Radium	93-95	interleukin 6	Mus musculus	21-25
10209249-3	1999	Our results indicate that RA produced by the CRBP I-expressing "glia-like" cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons.	Radium	26-28	retinol binding protein 1	Homo sapiens	45-51
10209249-3	1999	Our results indicate that RA produced by the CRBP I-expressing "glia-like" cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons.	Radium	26-28	retinol binding protein 1	Homo sapiens	122-129
10075925-4	1999	dnRARalpha formed heterodimers with endogenous retinoid X receptor-alpha (RXRalpha) over RA response elements in competition with remaining endogenous RARgamma-RXRalpha heterodimers, and dose-dependently impaired retinoid-dependent gene transcription.	Radium	2-4	retinoid X receptor alpha	Mus musculus	74-82
10668629-9	1999	The transfection of antisense oligonucleotide of COUP-TFI squelched the RA-dependent growth inhibition induced by RAR-RXR heterodimers.	Radium	72-74	nuclear receptor subfamily 2 group F member 1	Homo sapiens	49-57
10022884-6	1999	t-RA inhibited serum-induced JNK activity by blocking mitogen-activated protein (MAP) kinase kinase 4-induced signaling events.	Radium	2-4	mitogen-activated protein kinase 8	Homo sapiens	29-32
10022884-9	1999	These findings provide the first evidence that t-RA suppresses JNK activity by inhibiting JNK phosphorylation.	Radium	49-51	mitogen-activated protein kinase 8	Homo sapiens	63-66
10022884-9	1999	These findings provide the first evidence that t-RA suppresses JNK activity by inhibiting JNK phosphorylation.	Radium	49-51	mitogen-activated protein kinase 8	Homo sapiens	90-93
11601204-5	1999	hCT and CGRP levels increased gradually as RA was evoling into RAEB or RAEB was evolving into AML.	Radium	43-45	calcitonin related polypeptide alpha	Homo sapiens	8-12
10208436-2	1999	The cyclic AMP analog, 8-Cl-cAMP, acted synergistically with RA in inducing and activating retinoic acid receptor beta (RARbeta) which correlated with the growth inhibition, cell cycle arrest, and apoptosis in both cell types.	Radium	61-63	retinoic acid receptor beta	Homo sapiens	91-118
10208436-2	1999	The cyclic AMP analog, 8-Cl-cAMP, acted synergistically with RA in inducing and activating retinoic acid receptor beta (RARbeta) which correlated with the growth inhibition, cell cycle arrest, and apoptosis in both cell types.	Radium	61-63	retinoic acid receptor beta	Homo sapiens	120-127
10208436-3	1999	In addition, combined treatment of cells with RA plus 8-Cl-cAMP resulted in the release of cytochrome c, loss in mitochondrial membrane potential and activation of caspase-3 followed by cleavage of anti-poly(ADP-ribose)polymerase and <protein-id="5591">DNA-dependent protein kinase (catalytic subunit).	Radium	46-48	cytochrome c, somatic	Homo sapiens	91-103
10208436-3	1999	In addition, combined treatment of cells with RA plus 8-Cl-cAMP resulted in the release of cytochrome c, loss in mitochondrial membrane potential and activation of caspase-3 followed by cleavage of anti-poly(ADP-ribose)polymerase and <protein-id="5591">DNA-dependent protein kinase (catalytic subunit).	Radium	46-48	caspase 3	Homo sapiens	164-173
10208436-3	1999	In addition, combined treatment of cells with RA plus 8-Cl-cAMP resulted in the release of cytochrome c, loss in mitochondrial membrane potential and activation of caspase-3 followed by cleavage of anti-poly(ADP-ribose)polymerase and <protein-id="5591">DNA-dependent protein kinase (catalytic subunit).	Radium	46-48	poly(ADP-ribose) polymerase 1	Homo sapiens	203-229
10208436-4	1999	Interestingly</protein-id>, inhibition of caspase-3 activation blocked RA plus 8-Cl-cAMP induced apoptosis.	Radium	71-73	caspase 3	Homo sapiens	42-51
10208436-5	1999	Furthermore, mutations in a CRE-related motif within the RARbeta promoter resulted in loss of both transcriptional activation of RARbeta and synergy between RA and 8-Cl-cAMP.	Radium	57-59	retinoic acid receptor beta	Homo sapiens	129-136
10208436-8	1999	These findings suggest that RA and 8-Cl-cAMP act in a synergistic fashion in inducing apoptosis via caspase-3 activation, and may have potential for combination biotherapy for the treatment of malignant disease such as ovarian cancer.	Radium	28-30	caspase 3	Homo sapiens	100-109
10668629-9	1999	The transfection of antisense oligonucleotide of COUP-TFI squelched the RA-dependent growth inhibition induced by RAR-RXR heterodimers.	Radium	72-74	retinoic acid receptor alpha	Homo sapiens	114-117
10668629-9	1999	The transfection of antisense oligonucleotide of COUP-TFI squelched the RA-dependent growth inhibition induced by RAR-RXR heterodimers.	Radium	72-74	retinoid X receptor alpha	Homo sapiens	118-121
10352886-3	1999	We quantified the effects of the retinoic acids all-trans RA and 13-cis RA on alpha-actin and alpha-actinin at the subcellular level in cultures of chick embryo cardiomyocytes obtained from Hamburger and Hamilton"s (HH) stage 22, 32 and 40 embryos.	Radium	58-60	actin, alpha 2, smooth muscle, aorta	Gallus gallus	78-89
10352886-3	1999	We quantified the effects of the retinoic acids all-trans RA and 13-cis RA on alpha-actin and alpha-actinin at the subcellular level in cultures of chick embryo cardiomyocytes obtained from Hamburger and Hamilton"s (HH) stage 22, 32 and 40 embryos.	Radium	58-60	actinin, alpha 4	Gallus gallus	94-107
10352886-3	1999	We quantified the effects of the retinoic acids all-trans RA and 13-cis RA on alpha-actin and alpha-actinin at the subcellular level in cultures of chick embryo cardiomyocytes obtained from Hamburger and Hamilton"s (HH) stage 22, 32 and 40 embryos.	Radium	72-74	actin, alpha 2, smooth muscle, aorta	Gallus gallus	78-89
10352886-3	1999	We quantified the effects of the retinoic acids all-trans RA and 13-cis RA on alpha-actin and alpha-actinin at the subcellular level in cultures of chick embryo cardiomyocytes obtained from Hamburger and Hamilton"s (HH) stage 22, 32 and 40 embryos.	Radium	72-74	actinin, alpha 4	Gallus gallus	94-107
12114983-2	1999	For exploring the possible role of N-cadherin in neuronal differentiation in vitro, we chose RA induced P19 cell neuronal differentiation as a model system.	Radium	93-95	interleukin 23 subunit alpha	Homo sapiens	104-107
12114983-4	1999	The results showed that N-cadherin expression was increased rapidly during RA induction with its highest expression level at day 3 of neuronal differentiation, then down-regulated along with neuronal maturation.	Radium	75-77	cadherin 2	Homo sapiens	24-34
9824620-6	1998	In a cell line sensitive to RA-mediated inhibition of invasion, this ligand downregulated MMP-9 activity in cells grown on specific ECM molecules but not on plastic.	Radium	28-30	matrix metallopeptidase 9	Homo sapiens	90-95
9824620-8	1998	The effects of RA and MAPK signaling on MMP-9 activity was mediated at the transcriptional level.	Radium	15-17	matrix metallopeptidase 9	Homo sapiens	40-45
9734662-3	1998	Accumulating data support the concept that glucocorticoids down-regulate IL-6, whereas retinoic acid derivatives (RA) down-regulate IL-6R in myeloma.	Radium	114-116	interleukin 6 receptor	Homo sapiens	132-137
9832620-9	1998	Our results clearly indicate the usefulness of MH7A cells for investigating the regulation of rheumatoid FLSs and the IL-1 signal transduction pathway to develop future RA therapy.	Radium	169-171	interleukin 1 beta	Homo sapiens	118-122
9827847-10	1998	These observations are compatible with the suggestion that insulin analogues which bind to thyroid hormone binding proteins retain access to hepatic insulin receptors which primarily control Ra.	Radium	191-193	insulin	Homo sapiens	59-66
9774665-5	1998	We have previously reported that IFN-beta-all-trans-retinoic acid (RA) combination is a more potent growth suppressor of human tumor xenografts in vivo than either agent alone.	Radium	67-69	interferon beta 1	Homo sapiens	33-41
9755133-7	1998	Following RA, significantly increased COX-2 IP was detected in the MD and surrounding CTAL cells.	Radium	10-12	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	38-43
9755133-15	1998	There were significant increases in COX-2 expression in response to 2 wk RA serum.	Radium	73-75	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	36-41
9734662-7	1998	Effects of RA + DEX were also least able to be overcome by exogenous IL-6.	Radium	11-13	interleukin 6	Homo sapiens	69-73
9734662-8	1998	RA decreased IL-6R levels and addition of DEX to RA delayed recovery of IL-6R levels compared with RA alone.	Radium	0-2	interleukin 6 receptor	Homo sapiens	13-18
9734662-8	1998	RA decreased IL-6R levels and addition of DEX to RA delayed recovery of IL-6R levels compared with RA alone.	Radium	49-51	interleukin 6 receptor	Homo sapiens	72-77
9734662-8	1998	RA decreased IL-6R levels and addition of DEX to RA delayed recovery of IL-6R levels compared with RA alone.	Radium	49-51	interleukin 6 receptor	Homo sapiens	72-77
9734662-9	1998	Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels.	Radium	90-92	interleukin 6	Homo sapiens	40-44
9734662-9	1998	Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels.	Radium	90-92	interleukin 6	Homo sapiens	116-120
9734662-9	1998	Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels.	Radium	90-92	interleukin 6	Homo sapiens	116-120
9734662-10	1998	Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA.	Radium	42-44	interleukin 6 receptor	Homo sapiens	17-22
9734662-10	1998	Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA.	Radium	42-44	interleukin 6	Homo sapiens	17-21
9734662-11	1998	In summary, combinations of RA + DEX were not only more effective in inhibiting myeloma cells growth by the dual mechanisms of decreasing proliferative fraction and increasing apoptotic fraction, but were also less able to be overcome by IL-6.	Radium	28-30	interleukin 6	Homo sapiens	238-242
10453620-2	1998	Results showed that both RA and EA could increase the volume of microcirculatory blood flow in the cerebral pia mater; and that the increase in the EA group was superior to that in RA group.	Radium	25-27	RPTOR independent companion of MTOR complex 2	Homo sapiens	108-111
9679546-4	1998	Seven repeat retinoic acid response element (RARE) consensus half sites, A(G)GG(T)TC(G)A at +1521 to +1644 were identified in the cloned hGSTP1*C. Five of the RARE half-sites had the minimal spacer nucleotide requirement for functionality and DNA mobility shift analysis with different pairs of the RARE half-sites and supershift studies using antibodies against RAR-beta showed significant binding of nuclear protein complexes from RA-treated cells to these RAREs.	Radium	45-47	glutathione S-transferase pi 1	Homo sapiens	137-143
9593676-3	1998	A reporter gene assay using chloramphenicol acetyltransferase demonstrated that TR4 repressed RA-induced transactivation in a TR4 dose-dependent manner.	Radium	94-96	nuclear receptor subfamily 2 group C member 2	Homo sapiens	80-83
9593676-3	1998	A reporter gene assay using chloramphenicol acetyltransferase demonstrated that TR4 repressed RA-induced transactivation in a TR4 dose-dependent manner.	Radium	94-96	nuclear receptor subfamily 2 group C member 2	Homo sapiens	126-129
9553053-3	1998	This study demonstrates that the catalytic domain of p120 GTPase-activating protein (GAP), a well known Ras GAP, is able to interact physically with Rab5 and stimulate its GTPase activity.	Radium	104-107	RAS p21 protein activator 1	Homo sapiens	53-57
9553053-3	1998	This study demonstrates that the catalytic domain of p120 GTPase-activating protein (GAP), a well known Ras GAP, is able to interact physically with Rab5 and stimulate its GTPase activity.	Radium	104-107	RAB5A, member RAS oncogene family	Homo sapiens	149-153
9680111-6	1998	Among the growth regulatory proteins examined, the level of p21Waf1/Cip1 protein was found to increase after RA treatment, thus resulting in pRb hypophosphorylation which also induced the arrest of the cells at the G1 phase.	Radium	109-111	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-72
9680111-6	1998	Among the growth regulatory proteins examined, the level of p21Waf1/Cip1 protein was found to increase after RA treatment, thus resulting in pRb hypophosphorylation which also induced the arrest of the cells at the G1 phase.	Radium	109-111	RB transcriptional corepressor 1	Homo sapiens	141-144
9627584-4	1998	RESULTS: In response to a greater than tenfold increase in insulin concentration (from 7 +/- 2 to 79 +/- 13 microU/ml), there was a 20% decrease in leucine Ra (Basal: 272 +/- 27 mumol/kg/hr; Insulin: 226 +/- 29 mumol/kg/hr; p &lt; 0.01) and in phenylalanine Ra (Basal: 91 +/- 5 mumol/kg/hr; Insulin: 72 +/- 2 mumol/kg/hr; p &lt; 0.05).	Radium	156-158	insulin	Homo sapiens	59-66
9590130-10	1998	By contrast, 2 important molecules involved in cell-adhesion processes appeared to be up-regulated by RA exposure: focal adhesion kinase and E-cadherin, involved in adhesion plaque formation and cell-to-cell contacts, respectively.	Radium	102-104	cadherin 1	Homo sapiens	141-151
9564040-5	1998	In control cells, Ang II and TPA produced minimal increases in Ras-GTP level and Raf kinase activity.	Radium	63-66	angiotensinogen	Rattus norvegicus	18-24
9486168-12	1998	These results suggest that, during euglycemic clamps without somatostatin in normal dogs, Ra suppression is mediated by both peripheral and hepatic effects of insulin and that peripheral insulin, at least at high physiological infusion rates, is more potent than hepatic insulin in suppressing Ra.	Radium	90-92	insulin	Canis lupus familiaris	159-166
9543171-5	1998	Using trophoblast cells in culture, we then studied the effect on hCG secretion of 0.1 microM RA physiological forms and of selective RAR alpha and RXR alpha synthetic agonists.	Radium	94-96	chorionic gonadotropin subunit beta 5	Homo sapiens	66-69
9543171-6	1998	Only RXR alpha specific ligands such as physiological 9-cis RA and synthetic Ro 25-7386 stimulated hCG secretion (doubled).	Radium	60-62	retinoid X receptor alpha	Homo sapiens	5-14
9543171-6	1998	Only RXR alpha specific ligands such as physiological 9-cis RA and synthetic Ro 25-7386 stimulated hCG secretion (doubled).	Radium	60-62	chorionic gonadotropin subunit beta 5	Homo sapiens	99-102
9539472-8	1998	A subgroup analysis of patients with increased RA or LA volumes (&gt;1 SD of mean of controls) revealed a stronger relation between ANP and RA volumes than between ANP and LA volumes.	Radium	47-49	natriuretic peptide A	Homo sapiens	132-135
9539472-8	1998	A subgroup analysis of patients with increased RA or LA volumes (&gt;1 SD of mean of controls) revealed a stronger relation between ANP and RA volumes than between ANP and LA volumes.	Radium	140-142	natriuretic peptide A	Homo sapiens	132-135
9490660-11	1998	NO/O2-exposed neutrophils showed decreased viability at 2 h (31.7 +/- 3.7%, mean % viability +/- SD) compared with control (94.7 +/- 4.7%), O2 (75.6 +/- 9.3%), and NO/RA (62.8 +/- 14.9%; P &lt; 0.05 by ANOVA; n = 9).	Radium	167-169	immunoglobulin kappa variable 1D-39	Homo sapiens	0-5
9490660-11	1998	NO/O2-exposed neutrophils showed decreased viability at 2 h (31.7 +/- 3.7%, mean % viability +/- SD) compared with control (94.7 +/- 4.7%), O2 (75.6 +/- 9.3%), and NO/RA (62.8 +/- 14.9%; P &lt; 0.05 by ANOVA; n = 9).	Radium	167-169	immunoglobulin kappa variable 1D-39	Homo sapiens	3-5
9490660-13	1998	When compared with RA controls at 2 h, neutrophils exposed to NO/O2 showed significantly more apoptosis (292% of control, range: 106 to 2,488%, P &lt; 0.001 by ANOVA and Kruskal-Wallis) but not with exposure to NO/RA or O2 alone.	Radium	19-21	immunoglobulin kappa variable 1D-39	Homo sapiens	62-67
9490660-13	1998	When compared with RA controls at 2 h, neutrophils exposed to NO/O2 showed significantly more apoptosis (292% of control, range: 106 to 2,488%, P &lt; 0.001 by ANOVA and Kruskal-Wallis) but not with exposure to NO/RA or O2 alone.	Radium	19-21	immunoglobulin kappa variable 1D-39	Homo sapiens	65-67
9490660-13	1998	When compared with RA controls at 2 h, neutrophils exposed to NO/O2 showed significantly more apoptosis (292% of control, range: 106 to 2,488%, P &lt; 0.001 by ANOVA and Kruskal-Wallis) but not with exposure to NO/RA or O2 alone.	Radium	214-216	immunoglobulin kappa variable 1D-39	Homo sapiens	62-67
9490660-13	1998	When compared with RA controls at 2 h, neutrophils exposed to NO/O2 showed significantly more apoptosis (292% of control, range: 106 to 2,488%, P &lt; 0.001 by ANOVA and Kruskal-Wallis) but not with exposure to NO/RA or O2 alone.	Radium	214-216	immunoglobulin kappa variable 1D-39	Homo sapiens	65-67
9554467-9	1998	Recent data from our laboratory suggests that RA induction of the pit-1 gene can be impaired by pit-1 gene mutations.	Radium	46-48	POU class 1 homeobox 1	Homo sapiens	66-71
9467948-4	1998	Expression of hGDF3 in human EC cell lines is stem cell-specific, is down-regulated upon RA-mediated differentiation and is increased upon culture of the cells in the presence of activin A.	Radium	89-91	growth differentiation factor 3	Homo sapiens	14-19
9554467-9	1998	Recent data from our laboratory suggests that RA induction of the pit-1 gene can be impaired by pit-1 gene mutations.	Radium	46-48	POU class 1 homeobox 1	Homo sapiens	96-101
9444955-9	1997	The RA-induced differentiation and decrease of cell proliferation was blocked in myeloblastic leukemia HL-60 cells overexpressing the N-terminal region of Fli-1 at physiological concentrations of RA.	Radium	4-6	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	155-160
9852221-1	1998	We describe a predictive marker (CD95) for the responsiveness to tretinoin (RA) in acute promyelocytic leukemia (APL).	Radium	76-78	Fas cell surface death receptor	Homo sapiens	33-37
9852221-5	1998	We propose that CD95 can predict the clinical response to RA probably due to differentiation.	Radium	58-60	Fas cell surface death receptor	Homo sapiens	16-20
9718068-6	1998	Receptors for u-PA were evident on both RA and OA SF.	Radium	40-42	plasminogen activator, urokinase	Homo sapiens	14-18
9444955-9	1997	The RA-induced differentiation and decrease of cell proliferation was blocked in myeloblastic leukemia HL-60 cells overexpressing the N-terminal region of Fli-1 at physiological concentrations of RA.	Radium	196-198	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	155-160
9436964-4	1997	Expression of bcl-2 protein was seen in the proliferative zone in BE and showed a significant increase in RA but was essentially absent in HGD.	Radium	106-108	BCL2 apoptosis regulator	Homo sapiens	14-19
9436964-6	1997	We noted a positive correlation between Ki-67 and bcl-2 in the proliferative zone of BE and RA, whereas a negative correlation was present on the surface of RA.	Radium	92-94	BCL2 apoptosis regulator	Homo sapiens	50-55
9417874-6	1997	However, maximum RA resistance was obtained in cell lines in which the levels of both RAR-alpha and RXR-alpha were reduced.	Radium	17-19	retinoic acid receptor alpha	Homo sapiens	86-95
9417874-6	1997	However, maximum RA resistance was obtained in cell lines in which the levels of both RAR-alpha and RXR-alpha were reduced.	Radium	17-19	retinoid X receptor alpha	Homo sapiens	100-109
9392425-3	1997	The time course of the effect of 10 microM all-trans retinoic acid (at-RA) on apoA-I mRNA levels and protein secretion were comparable, i.e., minor increases were observed after a 24-h incubation and mRNA levels were increased 2.2- and 3.5-fold after 48 h and 72 h, respectively.	Radium	71-73	apolipoprotein A1	Homo sapiens	78-84
9371525-3	1997	In this study we have evaluated, by a cytofluorimetric method, the presence of HSP-70 in HL-60 cells during treatment with all-trans retinoic acid (ATRA), 9-cis retinoic acid (9-cis RA), and 13-cis retinoic acid (13-cis RA).	Radium	150-152	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-85
9371525-3	1997	In this study we have evaluated, by a cytofluorimetric method, the presence of HSP-70 in HL-60 cells during treatment with all-trans retinoic acid (ATRA), 9-cis retinoic acid (9-cis RA), and 13-cis retinoic acid (13-cis RA).	Radium	182-184	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-85
9351827-3	1997	Thus, AF-1 and AF-2 of distinct RARs exert specific cellular and molecular functions in a cell-autonomous system mimicking physiological situations, and their phosphorylation by kinases belonging to two main signalling pathways is required to enable RARs to transduce the RA signal during F9 cell differentiation.	Radium	32-34	interferon gamma receptor 2	Homo sapiens	6-19
9294605-1	1997	To investigate whether MAZ (Myc-associated zinc finger protein) affects the expression of the c-myc gene during the retinoic acid-induced (RA-induced) neuroectodermal differentiation of P19 embryonal carcinoma (EC) cells, we introduced a CAT reporter construct, human c-myc promoter/CAT (pMyc2CAT), and a mutant CAT derivative that lacked an ME1a1 site (pMyc1CAT) into P19EC cells to monitor the promoter activity of the c-myc gene.	Radium	139-141	MYC associated zinc finger protein	Homo sapiens	23-26
9376579-2	1997	Our studies showed that levels of C/EBP epsilon mRNA were markedly increased in NB4 cells (promyelocytic leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards granulocytes.	Radium	177-179	CCAAT enhancer binding protein epsilon	Homo sapiens	34-47
9376579-3	1997	Accumulation of C/EBP epsilon mRNA occurred as early as 1 hour after exposure of NB4 cells to 9-cis RA (5 x 10(-7) mol/L); and at 48 hours, levels were increased by 5.1-fold.	Radium	100-102	CCAAT enhancer binding protein epsilon	Homo sapiens	16-29
9376579-4	1997	Dose-response studies showed that 10(-7) to 10(-6) mol/L 9-cis RA (12 hours) resulted in peak levels of C/EBP epsilon mRNA; but even 10(-10) mol/L 9-cis RA increased levels of these transcripts.	Radium	63-65	CCAAT enhancer binding protein epsilon	Homo sapiens	104-117
9376579-8	1997	Furthermore, this C/EBP epsilon mRNA accumulation did not require synthesis of new protein factors because 9-cis RA induced C/EBP epsilon mRNA accumulation in the absence of new protein synthesis.	Radium	113-115	CCAAT enhancer binding protein epsilon	Homo sapiens	18-31
9376579-8	1997	Furthermore, this C/EBP epsilon mRNA accumulation did not require synthesis of new protein factors because 9-cis RA induced C/EBP epsilon mRNA accumulation in the absence of new protein synthesis.	Radium	113-115	CCAAT enhancer binding protein epsilon	Homo sapiens	124-137
9376579-10	1997	In contrast to the increase of C/EBP epsilon in 9-cis RA-mediated granulocytic differentiation, the DMSO-induced differentiation of HL-60 cells down the granulocytic pathway was associated with an initial reduction of C/EBP epsilon mRNA levels.	Radium	54-56	CCAAT enhancer binding protein epsilon	Homo sapiens	31-44
9278533-7	1997	Our findings raise the possibility that within HVC IGF-II acts as a paracrine signal between nonreplaceable area X-projecting neurons and replaceable RA-projecting neurons, a mode of action that is compatible with the involvement of IGF-II with the replacement of neurons.	Radium	150-152	insulin-like growth factor II	Taeniopygia guttata	51-57
9294605-2	1997	The expression of CAT in pMyc2CAT-transformed cells declined fivefold after 24 h in the presence of RA, returned to the normal level within 48 h, and decreased again to below 20% of the normal level after 96 h. By contrast, the expression of CAT in pMyc1CAT-transformed cells did not return to the normal level after 48 h in the presence of RA.	Radium	100-102	catalase	Homo sapiens	18-21
9294605-2	1997	The expression of CAT in pMyc2CAT-transformed cells declined fivefold after 24 h in the presence of RA, returned to the normal level within 48 h, and decreased again to below 20% of the normal level after 96 h. By contrast, the expression of CAT in pMyc1CAT-transformed cells did not return to the normal level after 48 h in the presence of RA.	Radium	100-102	catalase	Homo sapiens	30-33
9294605-2	1997	The expression of CAT in pMyc2CAT-transformed cells declined fivefold after 24 h in the presence of RA, returned to the normal level within 48 h, and decreased again to below 20% of the normal level after 96 h. By contrast, the expression of CAT in pMyc1CAT-transformed cells did not return to the normal level after 48 h in the presence of RA.	Radium	341-343	catalase	Homo sapiens	18-21
9294605-4	1997	Taken together, these results suggest that MAZ plays a key role in the transient increase in the expression of the c-myc gene after 48 h of exposure to RA during the neuroectodermal differentiation of P19EC cells.	Radium	152-154	MYC associated zinc finger protein	Homo sapiens	43-46
9294605-1	1997	To investigate whether MAZ (Myc-associated zinc finger protein) affects the expression of the c-myc gene during the retinoic acid-induced (RA-induced) neuroectodermal differentiation of P19 embryonal carcinoma (EC) cells, we introduced a CAT reporter construct, human c-myc promoter/CAT (pMyc2CAT), and a mutant CAT derivative that lacked an ME1a1 site (pMyc1CAT) into P19EC cells to monitor the promoter activity of the c-myc gene.	Radium	139-141	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
9294605-4	1997	Taken together, these results suggest that MAZ plays a key role in the transient increase in the expression of the c-myc gene after 48 h of exposure to RA during the neuroectodermal differentiation of P19EC cells.	Radium	152-154	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	115-120
9045737-6	1997	Moreover, we show that lMAN neurons are able to transport neurotrophins in the anterograde direction to RA, that neurotrophin-like immunoreactivity is present in cells in lMAN and RA, and that neurotrophin receptor-like immunoreactivity is present in RA.	Radium	104-106	brain derived neurotrophic factor	Homo sapiens	58-70
9379138-9	1997	However, initial 1,25(OH)2D3 liganding of a VDR monomer renders it competent not only to recruit RXR into a heterodimer but also to conformationally silence the ability of its RXR partner to bind 9-cis RA and dissociate the heterodimer.	Radium	202-204	vitamin D receptor	Homo sapiens	44-47
9379138-9	1997	However, initial 1,25(OH)2D3 liganding of a VDR monomer renders it competent not only to recruit RXR into a heterodimer but also to conformationally silence the ability of its RXR partner to bind 9-cis RA and dissociate the heterodimer.	Radium	202-204	retinoid X receptor alpha	Homo sapiens	176-179
9242550-4	1997	However, in APL patients achieving complete remission with t-RA therapy the bcr3-PML/RAR alpha product has been found associated with a poorer prognosis than bcr1-PML/RAR alpha.	Radium	61-63	retinoic acid receptor alpha	Homo sapiens	76-94
9242550-7	1997	T-RA binding analysis of nuclear and cytosolic extracts prepared from bcr3-PML/RAR alpha APL patients and from bcr3-PML/RAR alpha COS-1 transfected cells indicates that this protein is present only as high-molecular-weight nuclear complexes.	Radium	2-4	BCR pseudogene 3	Homo sapiens	70-74
9242550-7	1997	T-RA binding analysis of nuclear and cytosolic extracts prepared from bcr3-PML/RAR alpha APL patients and from bcr3-PML/RAR alpha COS-1 transfected cells indicates that this protein is present only as high-molecular-weight nuclear complexes.	Radium	2-4	retinoic acid receptor alpha	Homo sapiens	79-88
9242550-7	1997	T-RA binding analysis of nuclear and cytosolic extracts prepared from bcr3-PML/RAR alpha APL patients and from bcr3-PML/RAR alpha COS-1 transfected cells indicates that this protein is present only as high-molecular-weight nuclear complexes.	Radium	2-4	retinoic acid receptor alpha	Homo sapiens	70-88
9242550-11	1997	Consistent with these data, the binding of 9-cis-RA to the bcr3-PML/RAR alpha product resulted in increased transcriptional activation of the RA-responsive element (RARE) TRE, but not of the betaRARE, in transiently transfected COS-1 cells.	Radium	49-51	retinoic acid receptor alpha	Homo sapiens	59-77
9235929-4	1997	The affinities of Gap1(m) and p120GAP to the substrates determined by competitive inhibition by using Ha-Ras.GTPgammaS (guanosine 5"-O-(3-thiotriphosphate)) or R-Ras.GTPgammaS as a competitor agreed well with the substrate specificities of these GTPase-activating proteins.	Radium	105-108	RAS p21 protein activator 2	Homo sapiens	18-25
9235929-4	1997	The affinities of Gap1(m) and p120GAP to the substrates determined by competitive inhibition by using Ha-Ras.GTPgammaS (guanosine 5"-O-(3-thiotriphosphate)) or R-Ras.GTPgammaS as a competitor agreed well with the substrate specificities of these GTPase-activating proteins.	Radium	105-108	RAS p21 protein activator 1	Homo sapiens	30-37
9306960-3	1997	Epithelium of normal and inflamed mucosa, and hyperplastic epithelium, showed a residual G6PDH activity (RA) in oxygen that was always less than 20 per cent of the activity in the absence of oxygen.	Radium	105-107	glucose-6-phosphate dehydrogenase	Homo sapiens	89-94
9352625-3	1997	Retinoic acid (RA-, 1 microM)-treatment and aggregation for 4 days induced and greatly increased MASH-1, neuroD and NSCL-2 mRNA in P19 cells.	Radium	15-17	achaete-scute family bHLH transcription factor 1	Mus musculus	97-103
9352625-3	1997	Retinoic acid (RA-, 1 microM)-treatment and aggregation for 4 days induced and greatly increased MASH-1, neuroD and NSCL-2 mRNA in P19 cells.	Radium	15-17	neurogenic differentiation 1	Mus musculus	105-111
9352625-3	1997	Retinoic acid (RA-, 1 microM)-treatment and aggregation for 4 days induced and greatly increased MASH-1, neuroD and NSCL-2 mRNA in P19 cells.	Radium	15-17	nescient helix loop helix 2	Mus musculus	116-122
15624332-6	1997	9-cis RA was more potent than all-trans retinoic acid (ATRA) did in inducing terminal differentiation associated apoptosis and in downregulation of Bcl-2 expression.	Radium	6-8	BCL2 apoptosis regulator	Homo sapiens	148-153
9337080-9	1997	The presence of 9-cis RA or ATRA appeared to contribute to the further increase of CD14 in these cells.	Radium	22-24	CD14 molecule	Homo sapiens	83-87
9233783-4	1997	We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic acid (tRA) inhibited the cyclin D1 and D3 expression levels of human MCF-7, ZR-75 and T-47D breast carcinoma cells in vitro.	Radium	42-44	cyclin D1	Homo sapiens	94-103
9144408-3	1997	HX600 exhibited RXR pan-agonist activity in transient transfections with a DR1-based reporter gene and synergized with RA-bound RAR alpha and RAR beta in inducing transcription from a DR5-based reporter.	Radium	119-121	retinoic acid receptor alpha	Homo sapiens	128-137
9013670-1	1997	Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals.	Radium	29-32	AKT serine/threonine kinase 1	Homo sapiens	5-8
9031740-7	1997	At 32 micrograms kg-1 min-1, NPY raised RT by 133 +/- 22%, Ra,prox by 94 +/- 15%, Ra,micro by 277 +/- 104% and Rv by 81 +/- 11%.	Radium	59-61	neuropeptide Y	Homo sapiens	29-32
9031740-7	1997	At 32 micrograms kg-1 min-1, NPY raised RT by 133 +/- 22%, Ra,prox by 94 +/- 15%, Ra,micro by 277 +/- 104% and Rv by 81 +/- 11%.	Radium	82-84	neuropeptide Y	Homo sapiens	29-32
9013670-1	1997	Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals.	Radium	29-32	cell division cycle 42	Homo sapiens	13-18
9043087-6	1997	In addition, M33 null mutant mice show an aggravation of the skeletal malformations when treated to RA at embryonic day 7.5, leading to the hypothesis that, during development, the M33 gene might play a role in defining access to retinoic acid response elements localised in the regulatory regions of several Hox genes.	Radium	100-102	chromobox 2	Mus musculus	13-16
9005841-4	1996	Both 9-cis- and all-trans-RA were found to suppress parathyroid hormone (PTH) secretion from dispersed human adenomatous parathyroid cells, which was augmented by combined treatment with 1mM RA and 100 nM 1,25 (OH)2D3.	Radium	26-28	parathyroid hormone	Homo sapiens	52-71
9043087-6	1997	In addition, M33 null mutant mice show an aggravation of the skeletal malformations when treated to RA at embryonic day 7.5, leading to the hypothesis that, during development, the M33 gene might play a role in defining access to retinoic acid response elements localised in the regulatory regions of several Hox genes.	Radium	100-102	chromobox 2	Mus musculus	181-184
9360005-16	1997	The pattern of labeling seen in males indicates that CGRP acts selectively as a neuromodulator along the efferent projection from lateral MAN to RA and Area X but not in the HVC-to-RA pathway.	Radium	145-147	calcitonin related polypeptide alpha	Homo sapiens	53-57
9000050-2	1997	Driven by the suprabasal-specific keratin-10 gene promoter, expression of dnRXR alpha severely reduced the ability of RAR-selective ligands tRA and CD367 to induce epidermal mRNA levels of the CRABPII, CRBPI, and CRBPII genes, which contain RA-responsive elements (RAREs) DR1 and/or DR2.	Radium	118-120	cellular retinoic acid binding protein II	Mus musculus	193-200
9000050-2	1997	Driven by the suprabasal-specific keratin-10 gene promoter, expression of dnRXR alpha severely reduced the ability of RAR-selective ligands tRA and CD367 to induce epidermal mRNA levels of the CRABPII, CRBPI, and CRBPII genes, which contain RA-responsive elements (RAREs) DR1 and/or DR2.	Radium	118-120	retinol binding protein 1, cellular	Mus musculus	202-207
9022083-3	1997	To determine modes of retinoid action in the modulation of inflammatory responses, we explored effects of all-trans-retinoic acid (t-RA) on the TNFalpha-induced expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin in cultured human dermal microvascular endothelial cells.	Radium	133-135	tumor necrosis factor	Homo sapiens	144-152
9022083-3	1997	To determine modes of retinoid action in the modulation of inflammatory responses, we explored effects of all-trans-retinoic acid (t-RA) on the TNFalpha-induced expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin in cultured human dermal microvascular endothelial cells.	Radium	133-135	vascular cell adhesion molecule 1	Homo sapiens	175-208
9022083-3	1997	To determine modes of retinoid action in the modulation of inflammatory responses, we explored effects of all-trans-retinoic acid (t-RA) on the TNFalpha-induced expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin in cultured human dermal microvascular endothelial cells.	Radium	133-135	vascular cell adhesion molecule 1	Homo sapiens	210-216
9013706-7	1997	Stable overexpression of calreticulin in P19 embryonal carcinoma cells significantly decreases the rapid activation of the endogenous RA-responsive RARbeta gene, abrogates the ability of endogenous RAR/RXR complexes to bind to DNA, and inhibits the emergence of the RA-induced differentiated phenotype.	Radium	134-136	calreticulin	Homo sapiens	25-37
9013706-7	1997	Stable overexpression of calreticulin in P19 embryonal carcinoma cells significantly decreases the rapid activation of the endogenous RA-responsive RARbeta gene, abrogates the ability of endogenous RAR/RXR complexes to bind to DNA, and inhibits the emergence of the RA-induced differentiated phenotype.	Radium	134-136	retinoic acid receptor beta	Homo sapiens	148-155
9013706-7	1997	Stable overexpression of calreticulin in P19 embryonal carcinoma cells significantly decreases the rapid activation of the endogenous RA-responsive RARbeta gene, abrogates the ability of endogenous RAR/RXR complexes to bind to DNA, and inhibits the emergence of the RA-induced differentiated phenotype.	Radium	134-136	retinoic acid receptor beta	Homo sapiens	148-151
9000050-2	1997	Driven by the suprabasal-specific keratin-10 gene promoter, expression of dnRXR alpha severely reduced the ability of RAR-selective ligands tRA and CD367 to induce epidermal mRNA levels of the CRABPII, CRBPI, and CRBPII genes, which contain RA-responsive elements (RAREs) DR1 and/or DR2.	Radium	118-120	retinol binding protein 2, cellular	Mus musculus	213-219
9000050-2	1997	Driven by the suprabasal-specific keratin-10 gene promoter, expression of dnRXR alpha severely reduced the ability of RAR-selective ligands tRA and CD367 to induce epidermal mRNA levels of the CRABPII, CRBPI, and CRBPII genes, which contain RA-responsive elements (RAREs) DR1 and/or DR2.	Radium	118-120	down-regulator of transcription 1	Mus musculus	272-275
27405232-8	1997	Studies revealed that 9-cis RA alone down-regulated RXR, and diminished VDR and RAR protein levels in the presence of the vitamin D compounds in both cell lines.	Radium	28-30	retinoid X receptor alpha	Homo sapiens	52-55
27405232-8	1997	Studies revealed that 9-cis RA alone down-regulated RXR, and diminished VDR and RAR protein levels in the presence of the vitamin D compounds in both cell lines.	Radium	28-30	vitamin D receptor	Homo sapiens	72-75
27405232-8	1997	Studies revealed that 9-cis RA alone down-regulated RXR, and diminished VDR and RAR protein levels in the presence of the vitamin D compounds in both cell lines.	Radium	28-30	retinoic acid receptor alpha	Homo sapiens	80-83
8754791-2	1996	Downstream targets of insulin/IGF-1 that lead to adipocyte differentiation appear to include Ras, phosphatidylinositol (PI) 3-kinase, Raf, and mitogen-activated protein kinase.	Radium	93-96	insulin-like growth factor 1	Mus musculus	30-35
8912864-1	1996	Estradiol-mediated enhancement of retinoic acid receptor alpha (RARalpha) expression in the estrogen receptor (ER)-positive human breast carcinoma (HBC) cells results in their sensitivity to RA-mediated growth inhibition (A. K. Rishi et al., Cancer Res., 55: 4999-5006, 1995).	Radium	64-66	retinoic acid receptor alpha	Homo sapiens	34-62
8912864-1	1996	Estradiol-mediated enhancement of retinoic acid receptor alpha (RARalpha) expression in the estrogen receptor (ER)-positive human breast carcinoma (HBC) cells results in their sensitivity to RA-mediated growth inhibition (A. K. Rishi et al., Cancer Res., 55: 4999-5006, 1995).	Radium	64-66	estrogen receptor 1	Homo sapiens	92-109
8912864-1	1996	Estradiol-mediated enhancement of retinoic acid receptor alpha (RARalpha) expression in the estrogen receptor (ER)-positive human breast carcinoma (HBC) cells results in their sensitivity to RA-mediated growth inhibition (A. K. Rishi et al., Cancer Res., 55: 4999-5006, 1995).	Radium	64-66	estrogen receptor 1	Homo sapiens	111-113
8874184-10	1996	Altogether, these results suggest that ATRA/9-cis RA may play a key role in FL hematopoiesis via a dual effect hypothetically mediated by interaction with the RAR/RXR heterodimer, ie, inhibition of HSC/ primitive HPC proliferation and induction of CFU-GEMM/ BFU-E/CFU-M shift from the multipotent/erythroid/monocytic to the granulocytic-neutrophilic differentiation program.	Radium	41-43	retinoid X receptor alpha	Homo sapiens	163-166
8887541-8	1996	While Ras is constitutively activated in TNF-sensitive 10TEJ cells, TNF treatment increased Ras-bound GTP in TNF-sensitive L929 cells but not in TNF-resistant 10T1/2 cells.	Radium	6-9	tumor necrosis factor	Mus musculus	41-44
8904956-2	1996	Dosing with RA (100 mg/kg body weight) for 96 hours and exposure to [3H]RA enhanced the levels of radioactive incorporation of several nuclear matrix proteins, including p51, and p55, similarly in Y/AL and O/DR rats.	Radium	12-14	MAGUK p55 scaffold protein 1	Rattus norvegicus	179-182
8904956-2	1996	Dosing with RA (100 mg/kg body weight) for 96 hours and exposure to [3H]RA enhanced the levels of radioactive incorporation of several nuclear matrix proteins, including p51, and p55, similarly in Y/AL and O/DR rats.	Radium	72-74	MAGUK p55 scaffold protein 1	Rattus norvegicus	179-182
8954570-3	1996	When the [3H]RA-binding activity in the major peak was resolved on a Superose-12 size-exclusion column, a protein of about 15,000 Da, similar in size to CRABP I or II, was eluted.	Radium	13-15	cellular retinoic acid binding protein 1	Gallus gallus	153-160
8954570-4	1996	The identity of this RA-binding component as CRABP I was confirmed by its immunopositive reaction with a CRABP I-specific monoclonal antibody.	Radium	21-23	cellular retinoic acid binding protein 1	Gallus gallus	45-52
8954570-4	1996	The identity of this RA-binding component as CRABP I was confirmed by its immunopositive reaction with a CRABP I-specific monoclonal antibody.	Radium	21-23	cellular retinoic acid binding protein 1	Gallus gallus	105-112
8954570-6	1996	Equilibrium binding studies performed under saturating levels of RA indicated that the retinoid bound to the chick CRABP I with a Kd of 27 nM, a value similar to that reported for the native form of this protein from other species.	Radium	65-67	cellular retinoic acid binding protein 1	Gallus gallus	115-122
8954570-7	1996	Moreover, as indicated by their IC50 values, the relative binding affinities of various RA analogs for chick CRABP I are consistent with those obtained with human and mouse CRABP I.	Radium	88-90	cellular retinoic acid binding protein 1	Gallus gallus	109-116
8954570-7	1996	Moreover, as indicated by their IC50 values, the relative binding affinities of various RA analogs for chick CRABP I are consistent with those obtained with human and mouse CRABP I.	Radium	88-90	cellular retinoic acid binding protein I	Mus musculus	173-180
8911995-1	1996	The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA.	Radium	32-34	major histocompatibility complex, class II, DR beta 1	Homo sapiens	112-120
8911995-1	1996	The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA.	Radium	32-34	major histocompatibility complex, class II, DR beta 4	Homo sapiens	150-153
8911995-1	1996	The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA.	Radium	32-34	down-regulator of transcription 1	Homo sapiens	158-161
8911995-1	1996	The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA.	Radium	187-189	major histocompatibility complex, class II, DR beta 1	Homo sapiens	112-120
8911995-1	1996	The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA.	Radium	187-189	major histocompatibility complex, class II, DR beta 4	Homo sapiens	150-153
8911995-1	1996	The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA.	Radium	187-189	down-regulator of transcription 1	Homo sapiens	158-161
8947526-5	1996	The proportion of cellular p21-ras bound to GTP (ras-GTP level) was determined using immunoprecipitation of 32P-labeled cell lysates followed by thin layer chromatography and phosphoimaging analysis.	Radium	31-34	H3 histone pseudogene 16	Homo sapiens	27-30
8947526-13	1996	A positive correlation between the presence of K-ras mutation, increased ras-GTP level, and increased cell surface beta 1-6 N-linked carbohydrate exists in pancreatic cancer cell lines.	Radium	49-52	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	115-123
8798671-10	1996	The substrate specificity of DNA ligase IV differs from those of the other two cloned human DNA ligases, I and III, with regard to their ability to join the hybrid substrates oligo(dT).poly(rA) and oligo(rA).poly(dT).	Radium	190-192	DNA ligase 4	Homo sapiens	29-42
8798671-10	1996	The substrate specificity of DNA ligase IV differs from those of the other two cloned human DNA ligases, I and III, with regard to their ability to join the hybrid substrates oligo(dT).poly(rA) and oligo(rA).poly(dT).	Radium	190-192	DNA ligase 3	Homo sapiens	92-114
8784081-7	1996	The Ra of glucose was higher at the end of the recombinant human IFN alpha treatment day than in the control experiment (12.83 +/- 1.08 vs. 9.34 +/- 0.46 mumol/kg.min; P &lt; 0.03).	Radium	4-6	interferon alpha 1	Homo sapiens	65-74
9052993-4	1996	Our results indicate that ligands that interact with RARs only or both RARs and RXRs, including all-trans-retinoic acid (all-trans-RA), 9-cis-retinoic acid (9-cis-RA), 13-cis-retinoic acid (13-cis-RA), and several synthetic retinoids, suppress ECE16-1 cell proliferation, regulate expression of the retinoid-responsive differentiation marker cytokeratin K5, and increase RAR beta mRNA levels.	Radium	53-55	retinoic acid receptor beta	Homo sapiens	371-379
8695801-1	1996	We previously showed the involvement of retinoic acid receptor alpha (RAR alpha) in the induction of tissue-type plasminogen activator (t-PA) synthesis by RA in human umbilical vein endothelial cells (HUVECs).	Radium	70-72	retinoic acid receptor alpha	Homo sapiens	40-68
8695801-1	1996	We previously showed the involvement of retinoic acid receptor alpha (RAR alpha) in the induction of tissue-type plasminogen activator (t-PA) synthesis by RA in human umbilical vein endothelial cells (HUVECs).	Radium	70-72	plasminogen activator, tissue type	Homo sapiens	101-134
8695801-1	1996	We previously showed the involvement of retinoic acid receptor alpha (RAR alpha) in the induction of tissue-type plasminogen activator (t-PA) synthesis by RA in human umbilical vein endothelial cells (HUVECs).	Radium	70-72	plasminogen activator, tissue type	Homo sapiens	136-140
8695801-3	1996	Here, we show that the protein synthesis inhibitor, cycloheximide completely blocks the induction of t-PA by RA, which points to the need of an intermediary protein in t-PA stimulation.	Radium	109-111	plasminogen activator, tissue type	Homo sapiens	101-105
8695801-3	1996	Here, we show that the protein synthesis inhibitor, cycloheximide completely blocks the induction of t-PA by RA, which points to the need of an intermediary protein in t-PA stimulation.	Radium	109-111	plasminogen activator, tissue type	Homo sapiens	168-172
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	42-44	plasminogen activator, tissue type	Homo sapiens	154-158
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	42-44	retinoic acid receptor beta	Homo sapiens	114-122
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	42-44	plasminogen activator, tissue type	Homo sapiens	224-228
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	42-44	retinoic acid receptor alpha	Homo sapiens	114-117
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	42-44	retinoic acid receptor alpha	Homo sapiens	114-117
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	42-44	plasminogen activator, tissue type	Homo sapiens	224-228
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	114-116	retinoic acid receptor alpha	Homo sapiens	42-45
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	114-116	retinoic acid receptor beta	Homo sapiens	42-50
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	114-116	retinoic acid receptor alpha	Homo sapiens	42-45
8695801-4	1996	This intermediary protein is likely to be RAR beta 2 on the basis of the following findings: (1) the induction of RAR beta by RA exactly precedes that of t-PA; (2) HUVECs with elevated RAR beta mRNA levels show an undelayed t-PA induction on stimulation with RA, and this response can be almost completely inhibited with an RAR antagonist; and (3) an antisense oligodeoxynucleotide against the translation initiation site of RAR beta 2 mRNA greatly reduces the t-PA induction by RA.	Radium	114-116	retinoic acid receptor beta	Homo sapiens	42-50
8695801-5	1996	Thus, induction of t-PA by RA in HUVECs involves a 2-step mechanism requiring induction of RAR beta 2 via RAR alpha, followed by induction of t-PA synthesis via RAR beta 2.	Radium	27-29	plasminogen activator, tissue type	Homo sapiens	19-23
8695801-5	1996	Thus, induction of t-PA by RA in HUVECs involves a 2-step mechanism requiring induction of RAR beta 2 via RAR alpha, followed by induction of t-PA synthesis via RAR beta 2.	Radium	27-29	retinoic acid receptor alpha	Homo sapiens	91-94
8695801-5	1996	Thus, induction of t-PA by RA in HUVECs involves a 2-step mechanism requiring induction of RAR beta 2 via RAR alpha, followed by induction of t-PA synthesis via RAR beta 2.	Radium	27-29	retinoic acid receptor alpha	Homo sapiens	106-115
8695801-5	1996	Thus, induction of t-PA by RA in HUVECs involves a 2-step mechanism requiring induction of RAR beta 2 via RAR alpha, followed by induction of t-PA synthesis via RAR beta 2.	Radium	27-29	retinoic acid receptor alpha	Homo sapiens	106-109
8680987-3	1996	Senescent right atria (RA) were more sensitive to the negative chronotropic effects of R-phenylisopropyladenosine (R-PIA), a selective A1 receptor agonist, than adult RA (EC50: 4.8 +/- 0.7 vs 10.8 +/- 1.5 nM).	Radium	23-25	ribose 5-phosphate isomerase A	Rattus norvegicus	87-120
8697095-5	1996	Grb2 is found associated with mSOS, a GTP/GDP exchange factor involved in converting the inactive Ras-GDP to the active Ras-GTP.	Radium	98-101	growth factor receptor bound protein 2	Mus musculus	0-4
8768835-4	1996	The level of Ang II-ir was higher in PF than in plasma throughout the cycle, where as RA was in the same range of magnitude in the two compartments.	Radium	86-88	angiogenin	Homo sapiens	13-16
8887323-9	1996	We also show that mWnt-8 expression is ectopically induced in the rostral neural plate in response to RA exposure of presumitic (7-7.5 days post coitum) cultured mouse embryos.	Radium	102-104	wingless-type MMTV integration site family, member 8A	Mus musculus	18-24
8649786-12	1996	Our data show that the RA-cAMP synergistic effect on NB4 cell maturation and cooperation in triggering maturation of RA-primed NB4-R1 cells operate changes in the RXR/PML-RARalpha ratio which are both favouring RXRalpha.	Radium	23-25	retinoid X receptor alpha	Homo sapiens	163-166
8649786-12	1996	Our data show that the RA-cAMP synergistic effect on NB4 cell maturation and cooperation in triggering maturation of RA-primed NB4-R1 cells operate changes in the RXR/PML-RARalpha ratio which are both favouring RXRalpha.	Radium	23-25	PML nuclear body scaffold	Homo sapiens	167-170
8649786-12	1996	Our data show that the RA-cAMP synergistic effect on NB4 cell maturation and cooperation in triggering maturation of RA-primed NB4-R1 cells operate changes in the RXR/PML-RARalpha ratio which are both favouring RXRalpha.	Radium	23-25	retinoic acid receptor alpha	Homo sapiens	171-179
8649786-12	1996	Our data show that the RA-cAMP synergistic effect on NB4 cell maturation and cooperation in triggering maturation of RA-primed NB4-R1 cells operate changes in the RXR/PML-RARalpha ratio which are both favouring RXRalpha.	Radium	23-25	retinoid X receptor alpha	Homo sapiens	211-219
8649787-0	1996	cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha.	Radium	87-89	PML nuclear body scaffold	Homo sapiens	153-156
8780220-6	1996	IL-1 beta ra (200 micrograms) reversed the inhibition of gastric emptying by 34.8% (P &lt; 0.05) in the early (30 min) postoperative period and by 32.3% (P &lt; 0.05) in the late (120 min) postoperative period.	Radium	10-12	interleukin 1 beta	Rattus norvegicus	0-9
8634442-8	1996	In NB4 cells, using novel receptor-selective ligands such as 9-cis-RA, TTNPB, AM580, and SR11217, we found that RAR- and RARalpha-selective retinoids were able to induce growth arrest, granulocytic differentiation, and type II TGase, whereas the RXR-selective retinoid SR11217 was inactive.	Radium	66-69	retinoic acid receptor alpha	Homo sapiens	112-115
8634442-8	1996	In NB4 cells, using novel receptor-selective ligands such as 9-cis-RA, TTNPB, AM580, and SR11217, we found that RAR- and RARalpha-selective retinoids were able to induce growth arrest, granulocytic differentiation, and type II TGase, whereas the RXR-selective retinoid SR11217 was inactive.	Radium	66-69	retinoic acid receptor alpha	Homo sapiens	121-129
9157087-11	1996	A heterogenous association of DQB1 alleles with DR4 subtypes, influencing susceptibility to RA, suggests the DQB locus is not primarily associated with RA and susceptibility lies in the sequence 67-74 of the DRB1 loci.	Radium	92-94	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	30-34
9157087-11	1996	A heterogenous association of DQB1 alleles with DR4 subtypes, influencing susceptibility to RA, suggests the DQB locus is not primarily associated with RA and susceptibility lies in the sequence 67-74 of the DRB1 loci.	Radium	92-94	major histocompatibility complex, class II, DR beta 4	Homo sapiens	48-51
9157087-11	1996	A heterogenous association of DQB1 alleles with DR4 subtypes, influencing susceptibility to RA, suggests the DQB locus is not primarily associated with RA and susceptibility lies in the sequence 67-74 of the DRB1 loci.	Radium	92-94	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	30-33
9157088-5	1996	On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p &lt; 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.	Radium	131-133	major histocompatibility complex, class II, DP beta 1	Homo sapiens	37-45
9157088-5	1996	On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p &lt; 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.	Radium	131-133	major histocompatibility complex, class II, DP beta 1	Homo sapiens	41-45
9157088-5	1996	On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p &lt; 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.	Radium	131-133	major histocompatibility complex, class II, DP beta 1	Homo sapiens	37-40
8604295-7	1996	9-cis RA is a more potent ligand than all-trans RA to activate transcription via RXR/RAR heterodimers.	Radium	6-8	retinoid X receptor alpha	Homo sapiens	81-84
8604295-7	1996	9-cis RA is a more potent ligand than all-trans RA to activate transcription via RXR/RAR heterodimers.	Radium	6-8	retinoic acid receptor alpha	Homo sapiens	85-88
8631309-5	1996	These were promptly lost upon RA treatment in ES cells and in P19 EC cells, in parallel with sharply reduced Oct3/4 mRNA levels.	Radium	30-32	POU class 5 homeobox 1	Homo sapiens	109-115
8604295-7	1996	9-cis RA is a more potent ligand than all-trans RA to activate transcription via RXR/RAR heterodimers.	Radium	48-50	retinoid X receptor alpha	Homo sapiens	81-84
8604295-7	1996	9-cis RA is a more potent ligand than all-trans RA to activate transcription via RXR/RAR heterodimers.	Radium	48-50	retinoic acid receptor alpha	Homo sapiens	85-88
8549858-10	1996	Although a rise in insulin would have been expected to attenuate the Ra increment, this effect was overridden.	Radium	69-71	insulin	Homo sapiens	19-26
8909796-2	1996	GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol.	Radium	181-184	RAS p21 protein activator 1	Homo sapiens	28-35
8550565-5	1996	Therefore, mutations that impair Ras activity by perturbing regions that distinguish Ras-GDP from Ras-GTP (switch I and II) may disrupt interactions with either Raf-1-binding domain.	Radium	33-36	zinc fingers and homeoboxes 2	Homo sapiens	161-164
9140065-7	1996	In control P19 clones, the RA responsive element (RARE) and other elements in the promoter were protected after RA treatment.	Radium	27-29	cyclin dependent kinase inhibitor 2D	Homo sapiens	11-14
9140065-7	1996	In control P19 clones, the RA responsive element (RARE) and other elements in the promoter were protected after RA treatment.	Radium	50-52	cyclin dependent kinase inhibitor 2D	Homo sapiens	11-14
9140065-9	1996	CONCLUSIONS: These results indicate that the C-terminal region of RXR is required for full RARE occupancy in vivo, a RA dependent process that leads to the recruitment of other factors to the promoter and the subsequent transcriptional activation.	Radium	91-93	retinoid X receptor alpha	Homo sapiens	66-69
8564933-1	1996	We cultured human hepatoma Hep3B cells in the presence of RA (10(-5) M) for 30 days; the expression of both alpha-fetoprotein and hepatitis B virus surface antigen were suppressed over 70% at the transcriptional level by RA treatment.	Radium	58-60	alpha fetoprotein	Homo sapiens	108-125
8564933-1	1996	We cultured human hepatoma Hep3B cells in the presence of RA (10(-5) M) for 30 days; the expression of both alpha-fetoprotein and hepatitis B virus surface antigen were suppressed over 70% at the transcriptional level by RA treatment.	Radium	221-223	alpha fetoprotein	Homo sapiens	108-125
8555488-8	1996	We have also studied the effects of 9-cis RA and 13-cis RA on the expressions of TM and TF in NB4 and U937 cells.	Radium	42-44	coagulation factor III, tissue factor	Homo sapiens	88-90
8555488-8	1996	We have also studied the effects of 9-cis RA and 13-cis RA on the expressions of TM and TF in NB4 and U937 cells.	Radium	56-58	coagulation factor III, tissue factor	Homo sapiens	88-90
8555488-9	1996	A relatively wide range of 9-cis RA concentrations (0.01 to 1 mumol/L) compared with ATRA was optimal for prolongation of normal plasma-based recalcification time (reduction of cell surface TF activity), decrease of TF antigen, and increase of TM antigen on the surface and in the lysates of NB4 and U937 cells.	Radium	33-35	coagulation factor III, tissue factor	Homo sapiens	190-192
8555488-9	1996	A relatively wide range of 9-cis RA concentrations (0.01 to 1 mumol/L) compared with ATRA was optimal for prolongation of normal plasma-based recalcification time (reduction of cell surface TF activity), decrease of TF antigen, and increase of TM antigen on the surface and in the lysates of NB4 and U937 cells.	Radium	33-35	coagulation factor III, tissue factor	Homo sapiens	216-218
8555488-10	1996	Western blot analysis under nonreducing conditions showed that both ATRA and 9-cis RA markedly induced the prominent band at 75 kD of TM and reduced the band at 45 kD of TF.	Radium	70-72	coagulation factor III, tissue factor	Homo sapiens	170-172
8909796-2	1996	GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol.	Radium	181-184	neurofibromin 1	Homo sapiens	37-50
8909796-2	1996	GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol.	Radium	181-184	growth hormone releasing hormone	Homo sapiens	185-188
8749714-5	1995	Apparently, the change in protein synthesis after RA addition is regulated by another mechanism than eIF-4E phosphorylation.	Radium	50-52	eukaryotic translation initiation factor 4E	Homo sapiens	101-107
8929773-5	1996	Cathepsin G and elastase-like activities (IU/I) were slightly elevated in ReA SF compared to the corresponding peripheral blood values (11.4 +/- 9.2 vs 4.8 +/- 1.7, NS, and 5.1 +/- 2.8 vs 2.3 +/- 2.2, NS), which was similar to what was seen in RA (16.4 +/- 6.2 vs 0.53 +/- 0.4, p &lt; 0.05, and 6.51 +/- 1.8 vs 1.22 +/- 0.58, p &lt; 0.05).	Radium	244-246	cathepsin G	Homo sapiens	0-24
7585623-8	1995	Thus, we propose that the binding of anti-RA mAbs reflects the level of retinoids in the tissues and that this level is related strongly to RAR-beta expression.	Radium	42-44	retinoic acid receptor beta	Homo sapiens	140-148
7593213-7	1995	Long-term RA treatment decreased the expression of RXR alpha, but not RXR beta mRNAs.	Radium	10-12	retinoid X receptor alpha	Mus musculus	51-60
8835242-6	1995	In DR4+ RA patients, we observed a higher PRL peak at 60 min.	Radium	8-10	major histocompatibility complex, class II, DR beta 4	Homo sapiens	3-6
8835242-10	1995	In DR4+ RA patients, the overall prolactin secretion reflected by the AUC is increased compared to DR4- patients.	Radium	8-10	prolactin	Homo sapiens	33-42
8835242-10	1995	In DR4+ RA patients, the overall prolactin secretion reflected by the AUC is increased compared to DR4- patients.	Radium	8-10	major histocompatibility complex, class II, DR beta 4	Homo sapiens	99-102
7559588-5	1995	Nanomolar concentrations of RA induce a stable increase of TrkB mRNA.	Radium	28-30	neurotrophic receptor tyrosine kinase 2	Homo sapiens	59-63
7559588-6	1995	A transient induction of TrkA mRNA levels requires micromolar concentrations of RA.	Radium	80-82	neurotrophic receptor tyrosine kinase 1	Homo sapiens	25-29
7656983-1	1995	We have found that the gene expression of the ninth member of the fibroblast growth factor (FGF) family, FGF9 was induced during retinoic acid(RA)-induced neuronal differentiation of murine embryonal carcinoma P19 cells.	Radium	143-145	fibroblast growth factor 9	Homo sapiens	92-95
7575611-4	1995	Although 9-cis RA did not further enhance the transcriptional effects of the heterodimers activated by ciprofibrate, it greatly impaired the suppressive effects of COUP-TF on the ciprofibrate activated PPAR alpha/RXR alpha.	Radium	15-17	nuclear receptor subfamily 2 group F member 1	Homo sapiens	164-171
7575611-4	1995	Although 9-cis RA did not further enhance the transcriptional effects of the heterodimers activated by ciprofibrate, it greatly impaired the suppressive effects of COUP-TF on the ciprofibrate activated PPAR alpha/RXR alpha.	Radium	15-17	peroxisome proliferator activated receptor alpha	Homo sapiens	202-212
7575611-5	1995	We conclude that the antagonism by COUP-TF uncovers differential activation states of PPAR alpha/RXR alpha heterodimers in the absence and in the presence of 9-cis RA.	Radium	164-166	nuclear receptor subfamily 2 group F member 1	Homo sapiens	35-42
7575611-5	1995	We conclude that the antagonism by COUP-TF uncovers differential activation states of PPAR alpha/RXR alpha heterodimers in the absence and in the presence of 9-cis RA.	Radium	164-166	peroxisome proliferator activated receptor alpha	Homo sapiens	86-96
7575611-5	1995	We conclude that the antagonism by COUP-TF uncovers differential activation states of PPAR alpha/RXR alpha heterodimers in the absence and in the presence of 9-cis RA.	Radium	164-166	retinoid X receptor alpha	Homo sapiens	97-106
8745614-8	1995	The reductions in SBP measured in the morning and evening and in DBP measured in the morning were significantly greater in the group with low RA than in the group with high RA.	Radium	142-144	selenium binding protein 1	Homo sapiens	18-21
8745614-8	1995	The reductions in SBP measured in the morning and evening and in DBP measured in the morning were significantly greater in the group with low RA than in the group with high RA.	Radium	142-144	D-box binding PAR bZIP transcription factor	Homo sapiens	65-68
8745614-8	1995	The reductions in SBP measured in the morning and evening and in DBP measured in the morning were significantly greater in the group with low RA than in the group with high RA.	Radium	173-175	selenium binding protein 1	Homo sapiens	18-21
8745614-8	1995	The reductions in SBP measured in the morning and evening and in DBP measured in the morning were significantly greater in the group with low RA than in the group with high RA.	Radium	173-175	D-box binding PAR bZIP transcription factor	Homo sapiens	65-68
7565709-7	1995	We report here that 9-cis RA inhibits T-cell receptor-mediated apoptosis in T-cell hybridomas by blocking the expression of Fas ligand following activation.	Radium	26-28	Fas ligand	Homo sapiens	124-134
7656983-1	1995	We have found that the gene expression of the ninth member of the fibroblast growth factor (FGF) family, FGF9 was induced during retinoic acid(RA)-induced neuronal differentiation of murine embryonal carcinoma P19 cells.	Radium	143-145	fibroblast growth factor 9	Mus musculus	105-109
8590777-3	1995	When eight APL patients achieved complete remission by RA treatment, the EGF value decreased to 149.9 +/- 27.3 micrograms in the 24-h urine near to normal.	Radium	55-57	epidermal growth factor	Homo sapiens	73-76
7614737-7	1995	However, 3 out of 10 anti-endoglin mAbs reacted with significantly more RA versus normal ST lining cells (P &lt; 0.05), as well as RA compared to OA and normal macrophages (P &lt; 0.05).	Radium	72-74	endoglin	Homo sapiens	26-34
7614737-7	1995	However, 3 out of 10 anti-endoglin mAbs reacted with significantly more RA versus normal ST lining cells (P &lt; 0.05), as well as RA compared to OA and normal macrophages (P &lt; 0.05).	Radium	131-133	endoglin	Homo sapiens	26-34
7626109-4	1995	In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation.	Radium	113-116	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	55-63
7623814-5	1995	In CV-1 cells, the lactoferrin-RARE linked with a heterologous thymidine kinase promoter was strongly activated by RXR homodimers in response to 9-cis-retinoic acid (9-cis-RA) but not to all-trans-RA.	Radium	31-33	retinoid X receptor alpha	Homo sapiens	115-118
7623814-12	1995	By gel retardation analyses, we demonstrated that strong binding of the endogenous COUP-TF in breast cancer cells to the composite element contributed to diminished RA response in these cells.	Radium	165-167	nuclear receptor subfamily 2 group F member 1	Homo sapiens	83-90
7626109-4	1995	In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation.	Radium	113-116	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	178-186
7624147-7	1995	We conclude that neurofibromin functions as a major regulator of Ras-GTP in Schwann cells; however, mutation in NF1 by itself is unlikely to explain the hyperplasia observed in Schwann cell tumors in NF1 disease.	Radium	65-68	neurofibromin 1	Mus musculus	17-30
7615548-8	1995	Accordingly, we also find that 9-cis RA, which activates both RAR and RXR, is a more potent inducer of the RAR beta gene than RA, which only activates RAR.	Radium	37-39	retinoic acid receptor, alpha	Mus musculus	62-65
7615548-8	1995	Accordingly, we also find that 9-cis RA, which activates both RAR and RXR, is a more potent inducer of the RAR beta gene than RA, which only activates RAR.	Radium	37-39	retinoic acid receptor, beta	Mus musculus	107-115
7615548-8	1995	Accordingly, we also find that 9-cis RA, which activates both RAR and RXR, is a more potent inducer of the RAR beta gene than RA, which only activates RAR.	Radium	37-39	retinoic acid receptor, alpha	Mus musculus	107-110
7485998-4	1995	In RA-treated embryos, the previous study showed that intracellular TGF beta 1 levels were decreased, while those of extracellular TFG beta 1 were initially decreased but subsequently increased; here we found that TGF beta 1 RNA transcript levels were reduced following exposure to RA excess.	Radium	3-5	transforming growth factor, beta 1	Mus musculus	214-224
7485998-4	1995	In RA-treated embryos, the previous study showed that intracellular TGF beta 1 levels were decreased, while those of extracellular TFG beta 1 were initially decreased but subsequently increased; here we found that TGF beta 1 RNA transcript levels were reduced following exposure to RA excess.	Radium	282-284	transforming growth factor, beta 1	Mus musculus	214-224
7485998-1	1995	In a previous study we investigated the effects of RA excess on TGF beta protein localization in early postimplantation stages of mouse development.	Radium	51-53	transforming growth factor, beta 1	Mus musculus	64-72
7485998-5	1995	TGF beta 2 showed a clear disparity between the effects of RA excess on protein and RNA transcript levels: RNA transcript distribution was unchanged or showed a slight increase in RA-treated embryos, whereas the previous results showed greatly reduced protein levels.	Radium	59-61	transforming growth factor, beta 2	Mus musculus	0-10
7485998-4	1995	In RA-treated embryos, the previous study showed that intracellular TGF beta 1 levels were decreased, while those of extracellular TFG beta 1 were initially decreased but subsequently increased; here we found that TGF beta 1 RNA transcript levels were reduced following exposure to RA excess.	Radium	3-5	transforming growth factor, beta 1	Mus musculus	68-78
7485998-5	1995	TGF beta 2 showed a clear disparity between the effects of RA excess on protein and RNA transcript levels: RNA transcript distribution was unchanged or showed a slight increase in RA-treated embryos, whereas the previous results showed greatly reduced protein levels.	Radium	180-182	transforming growth factor, beta 2	Mus musculus	0-10
7485998-7	1995	The long-term nature of the effects of transient exposure to RA excess suggests that the mechanisms of RA-TGF beta interaction may be indirect.	Radium	61-63	transforming growth factor, beta 1	Mus musculus	106-114
7775449-3	1995	Unlike positive TREs, addition of the ligand 9-cis retinoic acid (9-cis RA) to cells transfected with a T3R beta 1 expression vector significantly reduces thyroid hormone inhibition of the TSH-beta gene, indicating that endogenous retinoid receptors antagonize T3R function.	Radium	72-74	thyroid stimulating hormone subunit beta	Homo sapiens	189-197
7540866-6	1995	As expected, the insulin effect to increase ras GTP formation and MAP kinase activity was negligible in A/K1018 cells but normal, or supernormal, in Y/F2 cells.	Radium	44-47	insulin	Homo sapiens	17-24
7775449-4	1995	Cotransfection of an RXR-alpha but not a retinoic acid receptor-alpha expression vector further antagonizes thyroid hormone inhibition, but only in the presence of 9-cis RA.	Radium	170-172	retinoid X receptor alpha	Homo sapiens	21-30
7775449-7	1995	A model is proposed whereby monomeric T3R is removed from a nTRE by RXR occupied by its ligand 9-cis RA.	Radium	101-103	retinoid X receptor alpha	Homo sapiens	68-71
7743514-7	1995	RA (1 microM)-mediated CRABP II increase was suppressed by IFN-gamma (10 ng/ml).	Radium	0-2	cellular retinoic acid binding protein 2	Homo sapiens	23-31
7743514-7	1995	RA (1 microM)-mediated CRABP II increase was suppressed by IFN-gamma (10 ng/ml).	Radium	0-2	interferon gamma	Homo sapiens	59-68
7723245-6	1995	In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux.	Radium	78-80	interleukin 1 beta	Mus musculus	68-77
7744805-4	1995	ET-1 stimulated Ras by increasing Ras GTP loading.	Radium	16-19	endothelin 1	Homo sapiens	0-4
7737364-5	1995	These studies allow ICAM-1 to be added to the list of genes transcriptionally activated by RA acting through an RARE element.	Radium	91-93	intercellular adhesion molecule 1	Homo sapiens	20-26
7655621-1	1995	All-trans retinoic acid (all-trans RA), the active metabolite of vitamin A, has been demonstrated to be an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia (APL), the AML3 subtype of the FAB cytological classification.	Radium	35-37	RUNX family transcription factor 2	Homo sapiens	205-209
7720709-2	1995	Like RA, these synthetic retinoids allow all three RAR types to repress AP1 (c-Jun/c-Fos) activity, demonstrating that the transactivation and transrepression functions of RARs can be dissociated by properly designed ligands.	Radium	5-7	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-75
7720709-2	1995	Like RA, these synthetic retinoids allow all three RAR types to repress AP1 (c-Jun/c-Fos) activity, demonstrating that the transactivation and transrepression functions of RARs can be dissociated by properly designed ligands.	Radium	5-7	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
7720709-2	1995	Like RA, these synthetic retinoids allow all three RAR types to repress AP1 (c-Jun/c-Fos) activity, demonstrating that the transactivation and transrepression functions of RARs can be dissociated by properly designed ligands.	Radium	5-7	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
7720709-3	1995	Using AP1 reporter cells, we also show that glucocorticoids or vitamin D3, together with either RA or these "dissociating" synthetic retinoids, can synergistically repress phorbol ester-induced AP1 activity.	Radium	96-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	6-9
7720709-3	1995	Using AP1 reporter cells, we also show that glucocorticoids or vitamin D3, together with either RA or these "dissociating" synthetic retinoids, can synergistically repress phorbol ester-induced AP1 activity.	Radium	96-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	194-197
7720709-4	1995	RA, but not these "dissociating" retinoids, induced transcription of an interleukin-6 promoter-based reporter gene transiently transfected into HeLa cells together with RARs.	Radium	0-2	interleukin 6	Homo sapiens	72-85
7720709-5	1995	Using Ki-ras-transformed 3T3 cells as a model system, we show that both RA and the "dissociating" retinoids inhibit anchorage-independent cell proliferation, suggesting that retinoid-induced growth inhibition may be related to AP1 transrepression.	Radium	72-74	jun proto-oncogene	Mus musculus	227-230
7720576-4	1995	As early as 2 hours following RA treatment at 10 days 8 hours post coitum, i.e. well before any morphogenetic effects are detectable, RAR-beta expression is specifically upregulated in the hindgut endoderm, and the abnormal expression pattern of RAR-gamma is also altered.	Radium	30-32	retinoic acid receptor, beta	Mus musculus	134-142
7720576-4	1995	As early as 2 hours following RA treatment at 10 days 8 hours post coitum, i.e. well before any morphogenetic effects are detectable, RAR-beta expression is specifically upregulated in the hindgut endoderm, and the abnormal expression pattern of RAR-gamma is also altered.	Radium	30-32	retinoic acid receptor, gamma	Mus musculus	246-255
7835286-3	1995	Using RNase protection analysis, we found that vitamin A deficiency led to a 2-fold increase in rat pituitary TSH beta messenger RNA (mRNA) levels, which returned to normal 18 h after treatment with RA (20 micrograms/rat).	Radium	199-201	thyroid stimulating hormone subunit beta	Rattus norvegicus	110-118
7835286-5	1995	Coadministration of RA and T3 (10 micrograms/100g body wt) to either vitamin A-deficient or vitamin A-deficient, hypothyroid animals caused decreases in TSH beta mRNA content that were indistinguishable from those seen with T3 alone.	Radium	20-22	thyroid stimulating hormone subunit beta	Rattus norvegicus	153-161
7835286-10	1995	Cotransfection with RAR alpha and retinoid X receptor-beta induced TSH beta expression by 3.5-fold, and treatment with RA suppressed this induction by 46%.	Radium	20-22	thyroid stimulating hormone subunit beta	Rattus norvegicus	67-75
7835286-11	1995	These results show that vitamin A levels play a significant role in regulating the expression of the TSH beta gene, but not the GH gene, in vivo and suggest that RA may suppress TSH beta gene transcription directly by an RAR-retinoid X receptor heterodimer-mediated mechanism.	Radium	162-164	thyroid stimulating hormone subunit beta	Rattus norvegicus	101-109
7835286-11	1995	These results show that vitamin A levels play a significant role in regulating the expression of the TSH beta gene, but not the GH gene, in vivo and suggest that RA may suppress TSH beta gene transcription directly by an RAR-retinoid X receptor heterodimer-mediated mechanism.	Radium	162-164	thyroid stimulating hormone subunit beta	Rattus norvegicus	178-186
7733941-5	1995	In contrast, addition of 1 microM RA maintained the amount of Ah-receptor-mRNA at the basal level as observed only in proliferating keratinocytes.	Radium	34-36	aryl hydrocarbon receptor	Homo sapiens	62-73
7794530-4	1995	The Ras-GTP/Ras-GDP ratios of NF1 derived melanocyte cultures were comparable to those derived from healthy donors.	Radium	4-7	neurofibromin 1	Homo sapiens	30-33
7730147-6	1995	All-trans retinoic acid (all-trans RA) at 1 nM or granulocyte macrophage colony-stimulating factor (GM-CSF) at 35 pM inhibited the wt-p53-induced apoptosis over a 42-h treatment.	Radium	35-37	tumor protein p53	Homo sapiens	134-137
7723245-6	1995	In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux.	Radium	78-80	beta-2 microglobulin	Mus musculus	143-150
7645420-21	1995	Pre-treatment of B16 cells with cyclic AMP prior to RA addition dramatically reduced induction of PKC alpha, an early marker of RA-induced cell differentiation.	Radium	52-54	protein kinase C, alpha	Mus musculus	98-107
7826398-4	1995	Similar decreases in BRE expression were observed in RA-treatment of the brain glioma cell U-251 and the promyelocytic cell HL-60.	Radium	53-55	BRISC and BRCA1 A complex member 2	Homo sapiens	21-24
8832901-1	1995	The stem cell-specific factor Oct-4 is expressed in undifferentiated embryonal carcinoma and embryonic stem cells and is quickly down regulated upon RA-induced differentiation.	Radium	149-151	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	30-35
7733619-7	1995	The fraction of Mac-1 positive cells increased to 90.5% (TPA), 80.6% (RA), 84.5% (SB) and decreased to 52.7% (DMSO).	Radium	70-72	integrin alpha M	Mus musculus	16-21
8832901-4	1995	However, in these cells Oct-4 promoter repression can be rescued in a RA-dependent manner by cotransfection of RAR alpha 2 or RAR beta 2 but not RARr gamma 1, matching previously reported transactivation properties of these receptor types.	Radium	70-72	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	24-29
8832901-4	1995	However, in these cells Oct-4 promoter repression can be rescued in a RA-dependent manner by cotransfection of RAR alpha 2 or RAR beta 2 but not RARr gamma 1, matching previously reported transactivation properties of these receptor types.	Radium	70-72	retinoic acid receptor, alpha	Mus musculus	111-114
8832901-4	1995	However, in these cells Oct-4 promoter repression can be rescued in a RA-dependent manner by cotransfection of RAR alpha 2 or RAR beta 2 but not RARr gamma 1, matching previously reported transactivation properties of these receptor types.	Radium	70-72	retinoic acid receptor, alpha	Mus musculus	126-129
8832901-7	1995	Although P19 EC cells contain weak binding activity interacting with the Oct-4 promoter HRE, strong binding activity is observed in nuclear extracts from RA-treated P19 cells.	Radium	154-156	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	73-78
8832901-10	1995	These results implicate RA and the action of its nuclear receptors in silencing Oct-4 expression upon differentiation of EC cells.	Radium	24-26	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	80-85
8832901-12	1995	Our results support models in which different nuclear receptor complexes sequentially occupy different sites in the Oct-4 promoter HRE to silence Oct-4 expression during RA-induced differentiation.	Radium	170-172	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	116-121
8832901-12	1995	Our results support models in which different nuclear receptor complexes sequentially occupy different sites in the Oct-4 promoter HRE to silence Oct-4 expression during RA-induced differentiation.	Radium	170-172	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	146-151
7987855-11	1994	9-cis RA down-regulates expression of the estrogen-responsive genes PR and pS2 in MCF-7 cells as reported previously for tRA.	Radium	6-8	trefoil factor 1	Homo sapiens	75-78
7520442-3	1994	Unlike the HIV-1 RT-associated RNase H, when challenged with unlabeled substrate, the recombinant p15 RNase H domain was relatively nonprocessive in RNA degradative activity of the [3H]poly(rA).poly(dT) duplex.	Radium	190-192	Vpr	Human immunodeficiency virus 1	98-101
7811230-2	1994	In vitamin A-deficient rats, the hepatic level of apoAI mRNA was increased and enhanced by an oral administration of excess retinoic acid(RA).	Radium	138-140	apolipoprotein A1	Rattus norvegicus	50-55
7528016-4	1994	This study suggests a role for the RA responsive cis-acting element in the RA induction of alpha-fetoprotein gene expression.	Radium	35-37	alpha-fetoprotein	Rattus norvegicus	91-108
8001825-6	1994	Full activation by recombinant RXR alpha/RAR alpha, however, requires the addition of either all-trans RA, 9-cis RA, or other RAR-specific agonists, whereas an RAR alpha-specific antagonist abolishes trans-activation.	Radium	103-105	retinoid X receptor alpha	Homo sapiens	31-40
8001825-6	1994	Full activation by recombinant RXR alpha/RAR alpha, however, requires the addition of either all-trans RA, 9-cis RA, or other RAR-specific agonists, whereas an RAR alpha-specific antagonist abolishes trans-activation.	Radium	103-105	retinoic acid receptor alpha	Homo sapiens	41-50
8001825-6	1994	Full activation by recombinant RXR alpha/RAR alpha, however, requires the addition of either all-trans RA, 9-cis RA, or other RAR-specific agonists, whereas an RAR alpha-specific antagonist abolishes trans-activation.	Radium	103-105	retinoic acid receptor alpha	Homo sapiens	41-44
7843800-3	1994	The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D.	Radium	76-78	solute carrier family 13 member 2	Rattus norvegicus	30-35
7520442-4	1994	Kinetic studies using p15 RNase H showed substrate inhibition with an apparent K(i) value of 0.12 micron for the [3H]poly(rA).poly(dT) hybrid.	Radium	122-124	cyclin dependent kinase inhibitor 2B	Homo sapiens	22-25
7922788-3	1994	Immuno-gold particles indicated that CA II was not confined to the ruffled border of RA alone, but also distributed in the cytoplasm of RA and SA.	Radium	85-87	carbonic anhydrase 2	Rattus norvegicus	37-42
7945277-6	1994	There are several modulators of Ras activity, such as the GTPase activating proteins (GAP1 and NF1), which stimulate the conversion of T-Ras to D-Ras.	Radium	32-35	neurofibromin 1	Homo sapiens	95-98
7912851-2	1994	Gem and Rad, the product of a gene overexpressed in skeletal muscle in individuals with Type II diabetes, constitute a new family of Ras-related GTP-binding proteins.	Radium	133-136	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	0-3
7912851-2	1994	Gem and Rad, the product of a gene overexpressed in skeletal muscle in individuals with Type II diabetes, constitute a new family of Ras-related GTP-binding proteins.	Radium	133-136	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	8-11
7922788-3	1994	Immuno-gold particles indicated that CA II was not confined to the ruffled border of RA alone, but also distributed in the cytoplasm of RA and SA.	Radium	136-138	carbonic anhydrase 2	Rattus norvegicus	37-42
7922788-4	1994	These findings suggest that RA may secrete protons produced by CA II via the ruffled border into enamel by active transport of vacuolar-type H(+)-ATPase.	Radium	28-30	carbonic anhydrase 2	Rattus norvegicus	63-68
7519185-7	1994	Comparison of reaction patterns with amino acid sequences suggest that the antibodies against subtypes of DR4 are specific primarily for a region containing sequences postulated to determine susceptibility to RA.	Radium	209-211	major histocompatibility complex, class II, DR beta 4	Homo sapiens	106-109
7987717-2	1994	The results showed that the DR4 was significantly associated with RA(RR = 3.1, chi 2 = 13.8, P &lt; 0.005).	Radium	66-68	major histocompatibility complex, class II, DR beta 4	Homo sapiens	28-31
7987717-7	1994	All subtypes that were positively associated with RA susceptibility had the RRAA (DRB1* 0404, 0405.	Radium	50-52	major histocompatibility complex, class II, DR beta 1	Homo sapiens	82-86
7987717-10	1994	The different DR4 subtype structures and frequencies may account for the different associations of DR4 with RA in various ethnic groups.	Radium	108-110	major histocompatibility complex, class II, DR beta 4	Homo sapiens	14-17
7987717-10	1994	The different DR4 subtype structures and frequencies may account for the different associations of DR4 with RA in various ethnic groups.	Radium	108-110	major histocompatibility complex, class II, DR beta 4	Homo sapiens	99-102
8205397-3	1994	Maximal tissue reactivity to anti-SP-A antibodies was found in the synovium of 55 rheumatoid patients exhibiting classical histopathological appearances of RA, in a pattern of immunostaining identical to that obtained with ML30, an antibody to mycobacterial heat shock protein 65kDa which, in turn, cross-reacted with SP-A in dot blot testing.	Radium	156-158	surfactant protein A1	Homo sapiens	34-38
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	interleukin 1 alpha	Homo sapiens	24-28
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	tumor necrosis factor	Homo sapiens	51-60
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	interleukin 1 alpha	Homo sapiens	225-229
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	tumor necrosis factor	Homo sapiens	263-272
18407207-5	1994	Since 9-cis RA also binds and activates the RARs, it is interesting to speculate that this natural ligand may regulate a broad range of physiologic processes by mediating transcriptional activity through both RAR- and RXR-linked pathways.	Radium	12-14	retinoic acid receptor alpha	Homo sapiens	44-47
18407207-5	1994	Since 9-cis RA also binds and activates the RARs, it is interesting to speculate that this natural ligand may regulate a broad range of physiologic processes by mediating transcriptional activity through both RAR- and RXR-linked pathways.	Radium	12-14	retinoid X receptor alpha	Homo sapiens	218-221
8207983-9	1994	This induced ATRA hypercatabolytic state should be monitored during consolidation therapy and at relapse by evaluating CRABP and RA metabolite levels, in order to detect ATRA resistance in patients with AML3.	Radium	15-17	cellular retinoic acid binding protein 1	Homo sapiens	119-124
8207983-9	1994	This induced ATRA hypercatabolytic state should be monitored during consolidation therapy and at relapse by evaluating CRABP and RA metabolite levels, in order to detect ATRA resistance in patients with AML3.	Radium	15-17	RUNX family transcription factor 2	Homo sapiens	203-207
8131741-5	1994	RA administration (which in APL patients induces blast differentiation and consequently complete remissions) causes the re-aggregation of PML and PBC auto-antigens onto the NB, while PML-RAR alpha remains mainly cytoplasmic.	Radium	0-2	PML nuclear body scaffold	Homo sapiens	138-141
21567024-6	1994	The apoptosis and increased expression of TGF-beta 1 could be completely blocked;by the addition of cycloheximide given within 12 h of RA treatment.	Radium	135-137	transforming growth factor beta 1	Homo sapiens	42-52
21567024-7	1994	It appears that the RA-induced apoptosis of SR-786 is the result of an RA-induced upregulation of RAR-alpha and a subsequent activation of TGF-beta 1, which in turn leads to a cascade of the suppression of growth-related genes.	Radium	20-22	retinoic acid receptor alpha	Homo sapiens	98-107
21567024-7	1994	It appears that the RA-induced apoptosis of SR-786 is the result of an RA-induced upregulation of RAR-alpha and a subsequent activation of TGF-beta 1, which in turn leads to a cascade of the suppression of growth-related genes.	Radium	20-22	transforming growth factor beta 1	Homo sapiens	139-149
21567024-7	1994	It appears that the RA-induced apoptosis of SR-786 is the result of an RA-induced upregulation of RAR-alpha and a subsequent activation of TGF-beta 1, which in turn leads to a cascade of the suppression of growth-related genes.	Radium	71-73	retinoic acid receptor alpha	Homo sapiens	98-107
21567024-7	1994	It appears that the RA-induced apoptosis of SR-786 is the result of an RA-induced upregulation of RAR-alpha and a subsequent activation of TGF-beta 1, which in turn leads to a cascade of the suppression of growth-related genes.	Radium	71-73	transforming growth factor beta 1	Homo sapiens	139-149
8131741-6	1994	Thus, PML-RAR alpha expression leads to a RA-reversible alteration of a nuclear domain.	Radium	10-12	PML nuclear body scaffold	Homo sapiens	6-9
8162861-6	1994	In the presence of RA both the mitogenic and differentiation inhibiting effects of bFGF are abolished, consistent with RA acting as an early regulator of oligodendrocyte differentiation.	Radium	19-21	fibroblast growth factor 2	Homo sapiens	83-87
8307946-3	1994	The formation of a Ras-Raf complex is absolutely dependent on prior treatment of the cells with a stimulus that activates Ras: phorbol ester or anti-T cell receptor antibody in the case of human peripheral blood T lymphoblasts, or epidermal growth factor in the case of Rat-1 fibroblasts.	Radium	19-22	zinc fingers and homeoboxes 2	Homo sapiens	23-26
8162861-6	1994	In the presence of RA both the mitogenic and differentiation inhibiting effects of bFGF are abolished, consistent with RA acting as an early regulator of oligodendrocyte differentiation.	Radium	119-121	fibroblast growth factor 2	Homo sapiens	83-87
7764679-6	1994	LPL immobilized directly to the surface of ChB without any spacer gave a higher stability than that immobilized with spacer, in spite of the lower RA.	Radium	147-149	lipoprotein lipase	Homo sapiens	0-3
7764679-7	1994	The spacer effect on RA could be explained in terms of the mobility of the immobilized LPL molecule.	Radium	21-23	lipoprotein lipase	Homo sapiens	87-90
8307946-3	1994	The formation of a Ras-Raf complex is absolutely dependent on prior treatment of the cells with a stimulus that activates Ras: phorbol ester or anti-T cell receptor antibody in the case of human peripheral blood T lymphoblasts, or epidermal growth factor in the case of Rat-1 fibroblasts.	Radium	19-22	epidermal growth factor	Homo sapiens	231-254
9969269-0	1994	Spin-lattice relaxation of Ra in Tl and g factor of the 213Ram, tau =2.1 ms isomer.	Radium	27-29	spindlin 1	Homo sapiens	0-4
8191901-5	1994	Ra peaked at 42.0 +/- 3.2 mumol kg-1 min-1 after approximately 15 min of exercise.	Radium	0-2	CD59 molecule (CD59 blood group)	Homo sapiens	37-42
7815831-9	1994	This induced ATRA hypercatabolytic state should be monitored during consolidation therapy and at relapse by evaluating CRABP and RA metabolite levels, in order to detect ATRA resistance in patients with AML3.	Radium	15-17	cellular retinoic acid binding protein 1	Homo sapiens	119-124
7815831-9	1994	This induced ATRA hypercatabolytic state should be monitored during consolidation therapy and at relapse by evaluating CRABP and RA metabolite levels, in order to detect ATRA resistance in patients with AML3.	Radium	15-17	RUNX family transcription factor 2	Homo sapiens	203-207
8230282-3	1993	We speculated that the decline in drug levels, indicating acquired resistance, resulted partly from inducible cytochrome-P450 oxidative enzymes, which can catabolize all-trans RA.	Radium	176-178	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	110-125
8983084-8	1994	A specific example of the synergistic action of SH2 and SH3 domains involves regulation of the Ras pathway by the adaptor protein Sem-5/drk/Grb2, which links tyrosine kinases to the Ras guanine nucleotide releasing protein Sos, which converts Ras to the active GTP-bound state.	Radium	95-98	growth factor receptor bound protein 2	Homo sapiens	140-144
8230282-14	1993	Ketoconazole attenuates this accelerated catabolism, suggesting that oxidation by cytochrome-P450 enzymes is an important pathway for both constitutive and induced pathways of all-trans RA metabolism.	Radium	186-188	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	82-97
8250895-4	1993	Similarly, the expression of PKC-delta was not altered in the cytosol, but was slightly reduced during the SP enhancement of RA-induced differentiation.	Radium	125-127	protein kinase C delta	Homo sapiens	29-38
8250895-1	1993	Differential changes in the expression of PKC isoenzymes in the RA-induced differentiation were noted.	Radium	64-66	protein kinase C alpha	Homo sapiens	42-45
8250895-6	1993	Concomitant with the decreased total PKC activity, there was a decline in the generation of sn-1,2-diacylglycerol (DAG) during the RA-induced differentiation.	Radium	131-133	protein kinase C alpha	Homo sapiens	37-40
8250895-2	1993	As measured by Western blot analysis, our results indicated the expressions of PKC-alpha, and -beta isoenzymes decreased in the cell membrane but increased in the cytosol during the RA-induced granulocytic differentiation.	Radium	182-184	protein kinase C alpha	Homo sapiens	79-88
8240229-7	1993	However, in the cases with pressure overloaded RA the amount of beta-MyHC was found to be 1.6 times higher than in the cases with normal pressure.	Radium	47-49	myosin heavy chain 6	Homo sapiens	69-73
8238506-2	1993	The rates of appearance (Ra) of glycerol and palmitic acid in plasma doubled from 2.08 +/- 0.22 and 1.63 +/- 0.20 mumol.kg-1 x min-1, respectively, after 12 h to 4.36 +/- 0.36 and 3.26 +/- 0.40 mumol.kg-1 x min-1, respectively, after 72 h of fasting (P &lt; 0.01).	Radium	25-27	CD59 molecule (CD59 blood group)	Homo sapiens	127-132
8238506-2	1993	The rates of appearance (Ra) of glycerol and palmitic acid in plasma doubled from 2.08 +/- 0.22 and 1.63 +/- 0.20 mumol.kg-1 x min-1, respectively, after 12 h to 4.36 +/- 0.36 and 3.26 +/- 0.40 mumol.kg-1 x min-1, respectively, after 72 h of fasting (P &lt; 0.01).	Radium	25-27	CD59 molecule (CD59 blood group)	Homo sapiens	207-212
8216300-5	1993	At concentrations close to the Kd for their respective receptors, 9-cis RA, AM580 (the RAR alpha agonist) and CD437 (the RAR gamma agonist) clearly upregulate the expression of the ALP gene, whereas the effect of CD2019 (the RAR beta agonist) is very modest.	Radium	72-74	retinoic acid receptor alpha	Homo sapiens	87-96
8216300-5	1993	At concentrations close to the Kd for their respective receptors, 9-cis RA, AM580 (the RAR alpha agonist) and CD437 (the RAR gamma agonist) clearly upregulate the expression of the ALP gene, whereas the effect of CD2019 (the RAR beta agonist) is very modest.	Radium	72-74	retinoic acid receptor gamma	Homo sapiens	121-130
8216300-5	1993	At concentrations close to the Kd for their respective receptors, 9-cis RA, AM580 (the RAR alpha agonist) and CD437 (the RAR gamma agonist) clearly upregulate the expression of the ALP gene, whereas the effect of CD2019 (the RAR beta agonist) is very modest.	Radium	72-74	alkaline phosphatase, placental	Homo sapiens	181-184
8216300-5	1993	At concentrations close to the Kd for their respective receptors, 9-cis RA, AM580 (the RAR alpha agonist) and CD437 (the RAR gamma agonist) clearly upregulate the expression of the ALP gene, whereas the effect of CD2019 (the RAR beta agonist) is very modest.	Radium	72-74	retinoic acid receptor beta	Homo sapiens	225-233
8411264-7	1993	Three days after RA treatment, islands of NT2/D1 cells showed increased expression of neurofilament proteins and increased phosphorylation of NF-M.	Radium	17-19	neurofilament medium chain	Homo sapiens	142-146
8368297-12	1993	The Ra response is enhanced by a decrease in insulin and probably by unknown stimuli.	Radium	4-6	insulin	Homo sapiens	45-52
8393784-8	1993	We also report that RXR alpha transcripts are down-regulated by RA-treatment in promyelocytic cells.	Radium	64-66	retinoid X receptor alpha	Homo sapiens	20-29
8363067-8	1993	PAI-1 levels in the GA group increased from 13.6 +/- 2.1 activity units (AU)/ml to 20.2 +/- 2.6 AU/ml at 24 h and returned to baseline at 72 h. In contrast, PAI-1 levels in the RA group remained unchanged over time.	Radium	177-179	serpin family E member 1	Homo sapiens	0-5
8363067-8	1993	PAI-1 levels in the GA group increased from 13.6 +/- 2.1 activity units (AU)/ml to 20.2 +/- 2.6 AU/ml at 24 h and returned to baseline at 72 h. In contrast, PAI-1 levels in the RA group remained unchanged over time.	Radium	177-179	serpin family E member 1	Homo sapiens	157-162
8388780-3	1993	These defects were previously observed in vitamin A-deficient animals and could be prevented by RA administration, demonstrating that RAR gamma mediates some of the retinoid signal in vivo.	Radium	96-98	retinoic acid receptor, gamma	Mus musculus	134-143
8508278-6	1993	Since PL has a diurnal rhythm of secretion in man with a peak at about 02.00 hours, it may contribute to the nocturnal worsening of RA.	Radium	132-134	prolactin	Homo sapiens	6-8
8508278-7	1993	We show that patients with RA secrete an excess of prolactin as evidenced by an upregulated diurnal periodicity and an abnormal increase in plasma prolactin concentration following surgery.	Radium	27-29	prolactin	Homo sapiens	51-60
8508278-7	1993	We show that patients with RA secrete an excess of prolactin as evidenced by an upregulated diurnal periodicity and an abnormal increase in plasma prolactin concentration following surgery.	Radium	27-29	prolactin	Homo sapiens	147-156
8376256-4	1993	Glycerol Ra and free fatty acid Ra in the athletes (7.33 +/- 0.68 and 14.88 +/- 1.35 mumol.kg-1 x min-1, respectively) were two- to threefold higher than the values in untrained control subjects (2.53 +/- 0.15 and 7.64 +/- 0.92 mumol.kg-1 x min-1, respectively; P &lt; 0.02).	Radium	9-11	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
8376256-4	1993	Glycerol Ra and free fatty acid Ra in the athletes (7.33 +/- 0.68 and 14.88 +/- 1.35 mumol.kg-1 x min-1, respectively) were two- to threefold higher than the values in untrained control subjects (2.53 +/- 0.15 and 7.64 +/- 0.92 mumol.kg-1 x min-1, respectively; P &lt; 0.02).	Radium	32-34	CD59 molecule (CD59 blood group)	Homo sapiens	98-103
8516298-1	1993	The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras.	Radium	168-171	neurofibromin 1	Homo sapiens	4-7
8516298-1	1993	The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras.	Radium	168-171	neurofibromin 1	Homo sapiens	82-95
8388780-5	1993	We also show that in utero RA-induced lumbosacral truncations are mediated by RAR gamma.	Radium	27-29	retinoic acid receptor, gamma	Mus musculus	78-87
8395280-2	1993	The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude of binding affinity toward [3H]retinoic acid (RA) as hRARs extracted from human cells (Ka values: 6.0 x 10(9) M-1 for rRAR alpha/E and 2.7 x 10(10) M-1 for both rRAR beta/E and rRAR gamma).	Radium	26-28	retinoic acid receptor, alpha	Rattus norvegicus	39-49
8495256-6	1993	In patients with a serum PgA below 17 micrograms/l, normal serum gastrin levels (&lt; 90 ng/l) as an indication of combined severe atrophy of antrum and corpus, were found in 1/13 patients with RA, in 3/11 with other rheumatic diseases and 2/12 with chronic non-rheumatic diseases (NS).	Radium	194-196	gastrin	Homo sapiens	65-72
8395280-2	1993	The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude of binding affinity toward [3H]retinoic acid (RA) as hRARs extracted from human cells (Ka values: 6.0 x 10(9) M-1 for rRAR alpha/E and 2.7 x 10(10) M-1 for both rRAR beta/E and rRAR gamma).	Radium	26-28	retinoic acid receptor, beta	Rattus norvegicus	53-62
8395280-2	1993	The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude of binding affinity toward [3H]retinoic acid (RA) as hRARs extracted from human cells (Ka values: 6.0 x 10(9) M-1 for rRAR alpha/E and 2.7 x 10(10) M-1 for both rRAR beta/E and rRAR gamma).	Radium	26-28	retinoic acid receptor, alpha	Rattus norvegicus	232-242
8395280-2	1993	The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude of binding affinity toward [3H]retinoic acid (RA) as hRARs extracted from human cells (Ka values: 6.0 x 10(9) M-1 for rRAR alpha/E and 2.7 x 10(10) M-1 for both rRAR beta/E and rRAR gamma).	Radium	26-28	retinoic acid receptor, beta	Rattus norvegicus	275-284
8437860-2	1993	Expression of the NF1-GAP-related domain (NF1GRD) has been shown to complement yeast strains deficient in the yeast GAP homologs, IRA1 and IRA2, to interact with human RAS proteins and to accelerate the conversion of ras-GTP to ras-GDP.	Radium	217-220	GTPase-activating protein IRA1	Saccharomyces cerevisiae S288C	130-134
7680292-10	1993	There was a significantly lower percentage of cells positive for OX-19, OX-8, OX-26 (transferrin receptor), and OX-39 (IL-2 receptor) in the RA group than in the IV group.	Radium	141-143	transferrin receptor	Rattus norvegicus	85-105
7682851-4	1993	Since Ra-Ni primarily cleaves covalently-bound sulfur species, this suggests that much more binding to human serum Alb occurred at a free cysteine residue than to human Hb.	Radium	6-8	albumin	Homo sapiens	115-118
8389001-6	1993	TAF-2 is located in the ligand-binding domain between amino acids 137 and 410 and activated transcription only in the presence of RA.	Radium	130-132	TATA-box binding protein associated factor 2	Homo sapiens	0-5
8437860-2	1993	Expression of the NF1-GAP-related domain (NF1GRD) has been shown to complement yeast strains deficient in the yeast GAP homologs, IRA1 and IRA2, to interact with human RAS proteins and to accelerate the conversion of ras-GTP to ras-GDP.	Radium	217-220	Ras GTPase activating protein IRA2	Saccharomyces cerevisiae S288C	139-143
7679907-3	1993	The purified p51 RT is a predominantly monomeric protein and it catalyses RNA-dependent DNA polymerization with poly(rA).oligo(dT) as the template.primer.	Radium	117-119	zinc finger protein 398	Homo sapiens	13-16
7679907-8	1993	Kinetic experiments show that the p15 RNAase H-mediated inhibition of p51 RT is competitive with respect to the poly(rA).oligo(dT) template.primer (Ki = 320 +/- 50 nM), and it does not interfere directly with the binding of dTTP to the enzyme.	Radium	117-119	cyclin dependent kinase inhibitor 2B	Homo sapiens	34-37
7679907-8	1993	Kinetic experiments show that the p15 RNAase H-mediated inhibition of p51 RT is competitive with respect to the poly(rA).oligo(dT) template.primer (Ki = 320 +/- 50 nM), and it does not interfere directly with the binding of dTTP to the enzyme.	Radium	117-119	zinc finger protein 398	Homo sapiens	70-73
8474061-3	1993	Five patients with RA, after previous anti-CD4 therapy (B-F5) without antimouse immunization were included in our open pilot study.	Radium	19-21	CD4 molecule	Homo sapiens	43-46
1469092-10	1992	In contrast, the sequence polymorphism linked to RA has been mapped to the HVR3 of the HLA-DRB1 gene and translates into a distinct domain of the HLA-DR molecule, the alpha-helical loop surrounding the antigen-binding groove.	Radium	49-51	major histocompatibility complex, class II, DR beta 1	Homo sapiens	87-95
8424283-8	1993	Insulin/blood glucose ratio increased significantly only in the RA group (P &lt; 0.05).	Radium	64-66	insulin	Homo sapiens	0-7
8424283-9	1993	The higher insulin secretion in response to glucose infusion in the RA group compared to the GA group may indicate an increased peripheral insulin resistance after regional anesthesia or, more likely, this secretion may be beneficial in contributing to improve postoperative nitrogen balance.	Radium	68-70	insulin	Homo sapiens	11-18
8424283-9	1993	The higher insulin secretion in response to glucose infusion in the RA group compared to the GA group may indicate an increased peripheral insulin resistance after regional anesthesia or, more likely, this secretion may be beneficial in contributing to improve postoperative nitrogen balance.	Radium	68-70	insulin	Homo sapiens	139-146
8382939-9	1993	The possibility that the morphogenetic effects of RA may be mediated through receptor interactions is raised by the finding that single mesenchymal blastemal cells in culture can express multiple RAR subtypes (delta 1 and alpha) and isoforms (delta 1 and delta 2).	Radium	50-52	delta like non-canonical Notch ligand 1	Homo sapiens	210-262
8490657-3	1993	We also show that NF1 deficient neuroblastomas show only moderately elevated ras-GTP levels, in contrast to NF1 tumour cells, indicating that neurofibromin contributes differently to the negative regulation of ras in different cell types.	Radium	77-80	neurofibromin 1	Homo sapiens	18-21
1334756-9	1992	Plasma ACE activity was inhibited in the RA 1 mg but not in the RA 10 micrograms group although conversion of angiotensin (Ang) I to Ang II in isolated aortic strips was suppressed in both treated groups.	Radium	41-43	angiotensin I converting enzyme	Rattus norvegicus	7-10
7683225-5	1993	RA-Pam sup only induced mast cell colonies in semisolid culture and failed to promote mast cell growth in a suspension culture.	Radium	0-2	peptidylglycine alpha-amidating monooxygenase	Mus musculus	3-6
8380175-7	1993	Addition of exogenous PTH or PTHrP to RA-treated EC or ES cells is an efficient replacement for dBcAMP in inducing full parietal endoderm differentiation.	Radium	38-40	parathyroid hormone-like peptide	Mus musculus	29-34
1469092-10	1992	In contrast, the sequence polymorphism linked to RA has been mapped to the HVR3 of the HLA-DRB1 gene and translates into a distinct domain of the HLA-DR molecule, the alpha-helical loop surrounding the antigen-binding groove.	Radium	49-51	major histocompatibility complex, class II, DR beta 1	Homo sapiens	87-90
1336976-6	1992	In response to exogenous RA, XRAR alpha 2 transcripts accumulate whilst the level of XRAR gamma decreases.	Radium	25-27	retinoic acid receptor beta L homeolog	Xenopus laevis	29-33
1336976-6	1992	In response to exogenous RA, XRAR alpha 2 transcripts accumulate whilst the level of XRAR gamma decreases.	Radium	25-27	retinoic acid receptor beta L homeolog	Xenopus laevis	85-89
1378478-3	1992	RA induced accumulation of CRABP-II transcripts throughout the epidermis, dermal fibroblasts, and endothelial cells as determined by in situ hybridization.	Radium	0-2	cellular retinoic acid binding protein 2	Homo sapiens	27-35
1328234-5	1992	Moreover, the level of CRABP-I determines the rate of RA metabolism to 4-oxo-RA such that the higher the CRABP-I level, the faster the metabolism of [3H]retinoic acid.	Radium	24-26	cellular retinoic acid binding protein 1	Homo sapiens	105-112
1447818-6	1992	Further, the differentiation study with TPA and RA revealed that the growth, S phase and also c-myc protein expression were suppressed during the differentiation.	Radium	48-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
1299543-2	1992	In comparison with normal control rats, RA in LRS and SHH rats showed an increasing trend, although no statistical significance appeared (P &gt; 0.05).	Radium	40-42	sonic hedgehog signaling molecule	Rattus norvegicus	54-57
1522232-12	1992	These results suggest that synovial production of MCP-1 may play an important role in the recruitment of mononuclear phagocytes during inflammation associated with RA and that synovial tissue macrophages are the dominant source of this cytokine.	Radium	164-166	C-C motif chemokine ligand 2	Homo sapiens	50-55
1328967-4	1992	These results suggest that isomerization of t-RA into c-RA may play an important role in retinoic acid biology.	Radium	46-48	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	54-58
1322605-7	1992	With poly(dT).oligo(rA) as a template primer, selective inhibition of the exonuclease activity by 5"-GMP results in a decrease in the amount of free dAMP generated which is complementary to the template DNA, suggesting the functional relationship between the editing exonuclease activity and the chain elongation activity of the EBV DNA polymerase molecule.	Radium	20-22	5'-nucleotidase, cytosolic II	Homo sapiens	101-104
1400313-1	1992	To investigate the mechanism(s) by which all-transretinoic acid (RA) inhibits cell growth, we studied its effect on the expression of c-fos and c-jun in B16 melanoma cells.	Radium	65-67	FBJ osteosarcoma oncogene	Mus musculus	134-139
1400313-1	1992	To investigate the mechanism(s) by which all-transretinoic acid (RA) inhibits cell growth, we studied its effect on the expression of c-fos and c-jun in B16 melanoma cells.	Radium	65-67	jun proto-oncogene	Mus musculus	144-149
1400313-3	1992	Suppression of c-fos was achieved with doses of RA as low as 10(-10) M and required pretreatment of cells with RA for a minimum of 2 h. In contrast, inhibition of c-jun required pretreatment for greater than 16 h with at least 10(-8) M RA and coincided with the observed decrease in cell growth.	Radium	48-50	FBJ osteosarcoma oncogene	Mus musculus	15-20
1400313-3	1992	Suppression of c-fos was achieved with doses of RA as low as 10(-10) M and required pretreatment of cells with RA for a minimum of 2 h. In contrast, inhibition of c-jun required pretreatment for greater than 16 h with at least 10(-8) M RA and coincided with the observed decrease in cell growth.	Radium	111-113	FBJ osteosarcoma oncogene	Mus musculus	15-20
1400313-3	1992	Suppression of c-fos was achieved with doses of RA as low as 10(-10) M and required pretreatment of cells with RA for a minimum of 2 h. In contrast, inhibition of c-jun required pretreatment for greater than 16 h with at least 10(-8) M RA and coincided with the observed decrease in cell growth.	Radium	111-113	FBJ osteosarcoma oncogene	Mus musculus	15-20
1400313-6	1992	Thus, the SRE plays a critical role in the suppression of c-fos transcription by RA.	Radium	81-83	FBJ osteosarcoma oncogene	Mus musculus	58-63
1378478-5	1992	RA-mediated accumulation of CRABP-II transcripts in skin was also confirmed by Northern analysis.	Radium	0-2	cellular retinoic acid binding protein 2	Homo sapiens	28-36
1378478-7	1992	These results indicate that RA-induced CRABP-II mRNA accumulation is primarily localized to spinous and granular layers in epidermis, and in superficial dermis.	Radium	28-30	cellular retinoic acid binding protein 2	Homo sapiens	39-47
1316927-5	1992	FPLC analysis also demonstrated a 15-kDa peak of specific RA binding activity, consistent with the presence of cellular retinoic acid binding protein (CRABP).	Radium	58-60	cellular retinoic acid binding protein 1	Homo sapiens	111-149
1358593-8	1992	4 days after RA exposure on day 8 + 5 hours, Hox-1.8 expression was shifted posteriorly by an effectively low dose of RA, which induced the formation of supernumerary ribs.	Radium	13-15	homeobox A10	Homo sapiens	45-52
1358593-8	1992	4 days after RA exposure on day 8 + 5 hours, Hox-1.8 expression was shifted posteriorly by an effectively low dose of RA, which induced the formation of supernumerary ribs.	Radium	118-120	homeobox A10	Homo sapiens	45-52
1358593-9	1992	Hox-1.8 expression was limited to posterior, disorganized mesenchyme, bulging out neural tube, some intestinal loops and the hindlimb in truncated embryos exposed to a high dose of RA.	Radium	181-183	homeobox A10	Homo sapiens	0-7
1629106-5	1992	The glucagon-to-insulin ratio was correlated with Ra over the entire exercise period (r = 0.63, P less than 0.0001), but not during the early part of exercise, when Ra increased rapidly.	Radium	50-52	insulin	Canis lupus familiaris	16-23
1629106-6	1992	The catecholamine- (epinephrine plus norepinephrine) to-insulin molar ratio was correlated with Ra during the early period (r = 0.52, P less than 0.01) and over the entire period of exercise (r = 0.66, P less than 0.0001).	Radium	96-98	insulin	Canis lupus familiaris	56-63
1316927-5	1992	FPLC analysis also demonstrated a 15-kDa peak of specific RA binding activity, consistent with the presence of cellular retinoic acid binding protein (CRABP).	Radium	58-60	cellular retinoic acid binding protein 1	Homo sapiens	151-156
1315151-2	1992	Differentiation induced by addition of RA to P19 EC cells cultured in monolayer is accompanied by a rapid increase in expression of both RAR alpha and -beta.	Radium	39-41	retinoic acid receptor alpha	Homo sapiens	137-156
1633851-1	1992	A selective tyrosine fluorescence quenching is found on interaction of vimentin with poly(dT) and poly(rA).	Radium	103-106	vimentin	Homo sapiens	71-79
1315151-5	1992	Aggregation of P19 EC cells in the presence of RA, but not DMSO, is accompanied by repression of RAR gamma, suggesting that the expression of RAR beta and RAR gamma during neuroectodermal differentiation is mutually exclusive.	Radium	47-49	retinoic acid receptor gamma	Homo sapiens	97-106
1315151-5	1992	Aggregation of P19 EC cells in the presence of RA, but not DMSO, is accompanied by repression of RAR gamma, suggesting that the expression of RAR beta and RAR gamma during neuroectodermal differentiation is mutually exclusive.	Radium	47-49	retinoic acid receptor beta	Homo sapiens	142-150
1315151-5	1992	Aggregation of P19 EC cells in the presence of RA, but not DMSO, is accompanied by repression of RAR gamma, suggesting that the expression of RAR beta and RAR gamma during neuroectodermal differentiation is mutually exclusive.	Radium	47-49	retinoic acid receptor gamma	Homo sapiens	155-164
1315151-6	1992	The effects of RA on RAR expression are significantly greater in G1 than in S-phase of the cell cycle.	Radium	15-17	retinoic acid receptor alpha	Homo sapiens	21-24
1330303-3	1992	The PML/RAR alpha fusion receptor--which is functionally altered--may block RA target genes, impair RA mediated differentiation and lead to transformation.	Radium	8-10	PML nuclear body scaffold	Homo sapiens	4-7
1576009-7	1992	Although RA inhibited total TRAP-positive MNC formation, it increased the ratio of stellate MNCs to smooth-margined MNC, suggesting that RA may have the ability to regulate the formation of active osteoclasts.	Radium	9-11	acid phosphatase 5, tartrate resistant	Rattus norvegicus	28-32
1774953-1	1991	It has been shown that patients with acute promyelocytic leukemia (AML3 subtype) treated with all-trans retinoic acid (all-trans RA), 45 mg/m2/day, achieve complete remission through differentiation of the leukemic clone to mature myeloid cells, which die spontaneously.	Radium	129-131	RUNX family transcription factor 2	Homo sapiens	67-71
1328791-2	1992	In the RA preparation, thrombin, as well as the three receptor-related peptides caused a relaxation in tissue that was precontracted with noradrenaline; the basic peptide, SFRGHITR, was inactive either as an agonist or as an antagonist to TRP42-55.	Radium	7-9	coagulation factor II	Rattus norvegicus	23-31
1657967-4	1991	In the present study we have identified a novel potential target of RA action by identifying an RA response element (RARE) in the human oxytocin (OT) gene promoter.	Radium	68-70	oxytocin/neurophysin I prepropeptide	Homo sapiens	136-144
1657967-4	1991	In the present study we have identified a novel potential target of RA action by identifying an RA response element (RARE) in the human oxytocin (OT) gene promoter.	Radium	68-70	oxytocin/neurophysin I prepropeptide	Homo sapiens	146-148
1657967-4	1991	In the present study we have identified a novel potential target of RA action by identifying an RA response element (RARE) in the human oxytocin (OT) gene promoter.	Radium	96-98	oxytocin/neurophysin I prepropeptide	Homo sapiens	136-144
1657967-4	1991	In the present study we have identified a novel potential target of RA action by identifying an RA response element (RARE) in the human oxytocin (OT) gene promoter.	Radium	96-98	oxytocin/neurophysin I prepropeptide	Homo sapiens	146-148
1657967-6	1991	RA elicited a marked stimulation of the transcriptional activity of the OT promoter in cells cotransfected with either the human RA receptor alpha, beta, or gamma.	Radium	0-2	oxytocin/neurophysin I prepropeptide	Homo sapiens	72-74
1917759-6	1991	On acute exposure, resting lactate Ra rose from sea level values to 2.2 +/- 0.2 mg.kg-1.min-1.	Radium	35-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
1918955-6	1991	Moreover, RA synovial fluid chemotactic activity for PMN in these fluids was inhibited 40 +/- 5% upon incubation with neutralizing polyclonal antibody to IL-8.	Radium	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
1918955-12	1991	These results suggest that macrophage-derived IL-8 may play an important role in the recruitment of PMN in synovial inflammation associated with RA.	Radium	145-147	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
1923522-2	1991	This GAP-related domain of the NF1 gene (NF1-GRD), like the GAP and IRA protein, has been reported to mediate hydrolysis of Ras-bound GTP to GDP, resulting in inactivation of Ras protein.	Radium	124-127	neurofibromin 1	Homo sapiens	31-34
1923522-2	1991	This GAP-related domain of the NF1 gene (NF1-GRD), like the GAP and IRA protein, has been reported to mediate hydrolysis of Ras-bound GTP to GDP, resulting in inactivation of Ras protein.	Radium	124-127	neurofibromin 1	Homo sapiens	41-44
1822394-8	1991	0.4 microgram/ml); b) increased expression of the normal remaining RAR alpha allele is rapidly observed and may explain the paradoxical induction of RA differentiation in these cells; c) CRABPII is induced in the bone marrow cells of AML3 patients and remains detectable 1 month after withdrawal of RA.	Radium	67-69	cellular retinoic acid binding protein 2	Homo sapiens	187-194
2037357-3	1991	The dermal inflammation-inducing activities of LPS and lipid A were roughly in the following order (from highest to lowest): Re-form LPS, Rc-form LPS and lipid A, Ra-form LPS, and S-form LPS.	Radium	163-165	toll-like receptor 4	Mus musculus	47-50
1822394-11	1991	It appears that the efficacy of all-trans RA is the resultant of multiple parameters (RA concentration, ratio of PML/RAR alpha transcripts to normal RAR alpha, CRABP) which need to be defined to efficiently monitor all-trans RA therapy in APL.	Radium	42-44	PML nuclear body scaffold	Homo sapiens	113-126
1822394-8	1991	0.4 microgram/ml); b) increased expression of the normal remaining RAR alpha allele is rapidly observed and may explain the paradoxical induction of RA differentiation in these cells; c) CRABPII is induced in the bone marrow cells of AML3 patients and remains detectable 1 month after withdrawal of RA.	Radium	149-151	retinoic acid receptor alpha	Homo sapiens	67-76
1822394-11	1991	It appears that the efficacy of all-trans RA is the resultant of multiple parameters (RA concentration, ratio of PML/RAR alpha transcripts to normal RAR alpha, CRABP) which need to be defined to efficiently monitor all-trans RA therapy in APL.	Radium	42-44	retinoic acid receptor alpha	Homo sapiens	117-126
1822394-11	1991	It appears that the efficacy of all-trans RA is the resultant of multiple parameters (RA concentration, ratio of PML/RAR alpha transcripts to normal RAR alpha, CRABP) which need to be defined to efficiently monitor all-trans RA therapy in APL.	Radium	42-44	cellular retinoic acid binding protein 1	Homo sapiens	160-165
1822394-8	1991	0.4 microgram/ml); b) increased expression of the normal remaining RAR alpha allele is rapidly observed and may explain the paradoxical induction of RA differentiation in these cells; c) CRABPII is induced in the bone marrow cells of AML3 patients and remains detectable 1 month after withdrawal of RA.	Radium	149-151	cellular retinoic acid binding protein 2	Homo sapiens	187-194
1822394-9	1991	AML3 in relapse after RA therapy is always less sensitive to RA in vitro and in vivo.	Radium	22-24	RUNX family transcription factor 2	Homo sapiens	0-4
1822394-9	1991	AML3 in relapse after RA therapy is always less sensitive to RA in vitro and in vivo.	Radium	61-63	RUNX family transcription factor 2	Homo sapiens	0-4
2093440-1	1990	D-Pen represents an effective treatment for a proportion of patients with RA and PSS.	Radium	74-76	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	2-5
1878148-10	1991	The production and hepatic balance of insulin were the lowest after ingestion of RA 12.	Radium	81-83	insulin	Sus scrofa	38-45
2250010-6	1990	The tyrosine fluorescence of TP2 was quenched upon binding to double-stranded and denatured DNA and poly(rA).	Radium	105-107	transition protein 2	Homo sapiens	29-32
2383261-4	1990	It is also demonstrated that the response of DNA polymerase gamma to N-ethylmaleimide is template dependent, and that DNA polymerase alpha has an authentic (albeit small) activity with poly(rA).oligo(dT).	Radium	190-192	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	118-138
1966045-10	1990	Correlation of these expression patterns with the morphogenetic effects of vitamin A deficiency and retinoid excess lead us to propose that the function of CRBP is to store and release retinol where high levels of RA are required for specific morphogenetic processes, while CRABP serves to sequester RA in regions where normal developmental functions require RA levels to be low.	Radium	214-216	retinol binding protein 1, cellular	Mus musculus	156-160
1966045-10	1990	Correlation of these expression patterns with the morphogenetic effects of vitamin A deficiency and retinoid excess lead us to propose that the function of CRBP is to store and release retinol where high levels of RA are required for specific morphogenetic processes, while CRABP serves to sequester RA in regions where normal developmental functions require RA levels to be low.	Radium	275-277	retinol binding protein 1, cellular	Mus musculus	156-160
1966045-10	1990	Correlation of these expression patterns with the morphogenetic effects of vitamin A deficiency and retinoid excess lead us to propose that the function of CRBP is to store and release retinol where high levels of RA are required for specific morphogenetic processes, while CRABP serves to sequester RA in regions where normal developmental functions require RA levels to be low.	Radium	275-277	retinol binding protein 1, cellular	Mus musculus	156-160
1966045-11	1990	Where both binding protein genes are expressed in a non-overlapping pattern within a large area of mesenchyme, a gradient of free RA may be created between them by release of retinol-derived RA from CRBP-expressing cells, with binding to CRABP enhancing the steepness of the decline in concentration distant to the source.	Radium	130-132	retinol binding protein 1, cellular	Mus musculus	199-203
1966045-11	1990	Where both binding protein genes are expressed in a non-overlapping pattern within a large area of mesenchyme, a gradient of free RA may be created between them by release of retinol-derived RA from CRBP-expressing cells, with binding to CRABP enhancing the steepness of the decline in concentration distant to the source.	Radium	191-193	retinol binding protein 1, cellular	Mus musculus	199-203
2221049-9	1990	The action of insulin to reverse the augmented net release of Phe and Leu was mediated exclusively by approximately 40% suppression of Ra (P less than 0.02) rather than a stimulation of Rd.	Radium	135-137	insulin	Homo sapiens	14-21
1967122-2	1990	The most direct evidence for the involvement of CD4+ T cells is provided by recent studies which demonstrate rapid improvement in the joint disease manifestations of RA following the infusion of anti-CD4 monoclonal antibodies (Herzog et al.	Radium	166-168	CD4 molecule	Homo sapiens	48-51
1967122-2	1990	The most direct evidence for the involvement of CD4+ T cells is provided by recent studies which demonstrate rapid improvement in the joint disease manifestations of RA following the infusion of anti-CD4 monoclonal antibodies (Herzog et al.	Radium	166-168	CD4 molecule	Homo sapiens	200-203
2193532-5	1990	Insulin resulted in a dose-dependent suppression of endogenous Leu Ra with group III = I greater than II.	Radium	67-69	insulin	Homo sapiens	0-7
2178777-2	1990	The RAS1 and RAS2 proteins overexpressed in ira mutants accumulated in the GTP-bound form, whereas in the wild-type strain the proteins were found mostly in the GDP-bound form, indicating that IRA1 and IRA2 negatively regulate the level of RAS-GTP.	Radium	4-7	TBL1X/Y related 1	Homo sapiens	193-197
2142712-5	1990	The myosin ATPase activity showed correlation with systemic RA pressure (y = 0.019x + 19.6, r = -0.68429), systemic RV pressure (y = 0.039x + 58.67, r = 0.73484), SVI (y = 0.05x + 18.1, r = 0.87587) and RV maxDp/Dt (y = 0.42x + 589.9, r = -0.67493) (p less than 0.05).	Radium	60-62	myosin heavy chain 14	Homo sapiens	4-10
2178777-2	1990	The RAS1 and RAS2 proteins overexpressed in ira mutants accumulated in the GTP-bound form, whereas in the wild-type strain the proteins were found mostly in the GDP-bound form, indicating that IRA1 and IRA2 negatively regulate the level of RAS-GTP.	Radium	4-7	Ras GTPase activating protein IRA2	Saccharomyces cerevisiae S288C	202-206
1967614-5	1990	However, similar elevations of the plasma G concentration did lead to higher values of Ra and plasma glucose, although the basal concentration of plasma insulin decreased the increases in Ra and plasma glucose caused by G. The ability of a similar amount of insulin to lower plasma FFA concentrations was greater in magnitude than the decrease in Ra.	Radium	188-190	insulin	Homo sapiens	153-160
2311228-6	1990	The mean rate constant for all materials was 0.23 min-1 for the aca and 1.42 min-1 for the RA-1000, significantly different (P less than 0.001).	Radium	91-93	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
19815670-9	2009	CONCLUSIONS: These results suggest that although IL-23 may have pathogenic activity in a proportion of patients with late-stage RA, it is not abundantly produced in this inflammatory tissue, nor does it have a dominant role in all patient tissues analysed.	Radium	128-130	interleukin 23 subunit alpha	Homo sapiens	49-54
33818009-5	2021	There was a significant difference in the percentage of individuals achieving >=5% weight loss after 3, 6, and 9 months, with most occurring in the GLP-1-RA-based WLP group.	Radium	154-156	glucagon like peptide 1 receptor	Homo sapiens	148-153
33818009-7	2021	CONCLUSIONS: GLP-1-RA-based WLP therapies were found to be more effective for treating post-bariatric weight regain than non-GLP-1-RA-based WLP or ILM, regardless of surgery type.	Radium	19-21	glucagon like peptide 1 receptor	Homo sapiens	13-18
33034957-7	2020	Further, NR6A1 promoted neuronal marker protein MAP2 expression in RA-induced neurodifferentiation of NT-2 cells and testicular tumor xenografts.	Radium	67-69	nuclear receptor subfamily 6 group A member 1	Homo sapiens	9-14
33034957-7	2020	Further, NR6A1 promoted neuronal marker protein MAP2 expression in RA-induced neurodifferentiation of NT-2 cells and testicular tumor xenografts.	Radium	67-69	microtubule associated protein 2	Homo sapiens	48-52
2177813-5	1990	These findings are consistent with the differentiation-associated growth limitation and with the decreased myeloperoxidase activity reported in RA-treated cultures in other studies.	Radium	144-146	myeloperoxidase	Homo sapiens	107-122
2190176-4	1990	In the development of the limb bud, RA has been proposed as a morphogen controlling development via a concentration gradient established by a mechanism thought to involve specific nuclear receptors and a cytosolic binding protein (CRABP).	Radium	36-38	cellular retinoic acid binding protein 1	Homo sapiens	231-236
33591443-10	2021	These results provide evidence suggesting an important role of RA-derived GDNF in intrinsic brain repair and recovery after FIS, and thus targeting GDNF in RAs may be effective for stroke therapy.	Radium	63-65	glial cell derived neurotrophic factor	Rattus norvegicus	74-78
34668637-9	2022	Study findings remained consistent when restricted to GLP-1 RA users.	Radium	60-62	glucagon like peptide 1 receptor	Homo sapiens	54-59
34448208-6	2022	RESULTS: Ten studies included, summarizing GLP1-RA use in 23 PWS patients (age, 13-37 years), who had used either exenatide (n = 14) or liraglutide (n = 9) over a duration of 14 weeks to 4 years.	Radium	48-50	glucagon like peptide 1 receptor	Homo sapiens	43-47
34766472-10	2022	CONCLUSION: Our findings suggested that BZRAP1-AS1 sequestered miR-1286 and reshaped the COL5A2 expression, thereby suppressed RA-HFLS proliferation and inflammation, and triggered cell apoptosis, resulting in the attenuation of RA progression.	Radium	229-231	TSPO associated protein 1	Homo sapiens	40-46
34933161-1	2022	Growing evidence indicates that synovial hypoxia-inducible factor 1alpha (HIF-1alpha) can be as a promising target for RA therapy.	Radium	119-121	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	41-72
34933161-1	2022	Growing evidence indicates that synovial hypoxia-inducible factor 1alpha (HIF-1alpha) can be as a promising target for RA therapy.	Radium	119-121	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	74-84
34766472-10	2022	CONCLUSION: Our findings suggested that BZRAP1-AS1 sequestered miR-1286 and reshaped the COL5A2 expression, thereby suppressed RA-HFLS proliferation and inflammation, and triggered cell apoptosis, resulting in the attenuation of RA progression.	Radium	229-231	prostaglandin D2 receptor	Homo sapiens	47-50
34823203-4	2022	Naturally occurring radioactive materials (NORM) are a class of contaminants found in some oil and gas infrastructure (e.g. pipelines) and includes radionuclides of uranium, thorium, radium, radon, lead, and polonium.	Radium	183-189	gastrin	Homo sapiens	99-102
34994166-7	2021	On the other hand, meiotic initiation of the fetal germ cells required Dennd1a-mediated RA production from the somatic cells, which induced the expression of Stra8 and Rec8.	Radium	88-90	DENN/MADD domain containing 1A	Mus musculus	71-78
34994166-7	2021	On the other hand, meiotic initiation of the fetal germ cells required Dennd1a-mediated RA production from the somatic cells, which induced the expression of Stra8 and Rec8.	Radium	88-90	stimulated by retinoic acid gene 8	Mus musculus	158-163
34994166-7	2021	On the other hand, meiotic initiation of the fetal germ cells required Dennd1a-mediated RA production from the somatic cells, which induced the expression of Stra8 and Rec8.	Radium	88-90	REC8 meiotic recombination protein	Mus musculus	168-172
34930349-3	2021	We examined the effects of IL-1beta, IL-1 ra and AICAR on the production of IL-8, MCP-1, PGE2 and PGF2alpha in human ESCs.	Radium	42-44	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
34866306-12	2022	At week 52, HbA1c decreased by 0.46% with imeglimin monotherapy, by 0.56% - 0.92% with imeglimin as oral combination therapy, and by 0.12% with injectable GLP1-RA combination therapy.	Radium	160-162	glucagon like peptide 1 receptor	Homo sapiens	155-159
34605362-5	2021	Characteristics with the greatest influence on preference towards TPO-RA treatments were method of administration (odds ratio (OR) 5.6, 95% confidence interval (CI) 3.2-10.1) and drug-food interactions (OR 3.2, 95% CI 1.8-5.7).	Radium	70-72	thyroid peroxidase	Homo sapiens	66-69
34605362-7	2021	CONCLUSION: This is the first study to quantify the preference of individuals with ITP towards TPO-RA treatment attributes and demonstrates preference for orally administered treatments, without drug-food interactions.	Radium	99-101	thyroid peroxidase	Homo sapiens	95-98
34547980-7	2021	In the periods before, during and after TPO-RA treatment, oral corticosteroids were the most commonly used therapy (64.4%, 43.4% and 36.1% of patients, respectively); median cumulative doses across each period were 2521.9, 2000.0 and 2277.8 mg.	Radium	44-46	thyroid peroxidase	Homo sapiens	40-43
34474187-13	2021	In addition, 29 signaling pathways were found to be involved in RA-RRM-induced amelioration, including the NF-kappaB, TNF, TGF-beta, VEGF, and HIF-1 signaling pathways, using KEGG analysis.	Radium	64-66	nuclear factor kappa B subunit 1	Homo sapiens	107-116
34796915-4	2022	By employing an in vitro osteoclastogenesis model, this study investigates the effects and mechanisms of RA on intracellular signaling induced by receptor activator of nuclear factor-kappaB ligand (RANKL).	Radium	105-107	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	146-196
34796915-4	2022	By employing an in vitro osteoclastogenesis model, this study investigates the effects and mechanisms of RA on intracellular signaling induced by receptor activator of nuclear factor-kappaB ligand (RANKL).	Radium	105-107	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	198-203
34796915-8	2022	Mechanistically, RA suppressed TNF receptor-associated factor 6 (TRAF6), the crucial adaptor protein following RANKL-RANK binding.	Radium	17-19	TNF receptor-associated factor 6	Mus musculus	31-63
34796915-8	2022	Mechanistically, RA suppressed TNF receptor-associated factor 6 (TRAF6), the crucial adaptor protein following RANKL-RANK binding.	Radium	17-19	TNF receptor-associated factor 6	Mus musculus	65-70
34796915-8	2022	Mechanistically, RA suppressed TNF receptor-associated factor 6 (TRAF6), the crucial adaptor protein following RANKL-RANK binding.	Radium	17-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	111-116
34796915-9	2022	On the one hand, RA downregulated the nuclear factor-kappaB (NF-kappaB) activity, extracellular regulated protein kinases (ERK) phosphorylation, and calcium oscillations.	Radium	17-19	mitogen-activated protein kinase 1	Mus musculus	82-121
34796915-9	2022	On the one hand, RA downregulated the nuclear factor-kappaB (NF-kappaB) activity, extracellular regulated protein kinases (ERK) phosphorylation, and calcium oscillations.	Radium	17-19	mitogen-activated protein kinase 1	Mus musculus	123-126
34796915-10	2022	On the other hand, RA upregulated the antioxidative response element (ARE) response and the protein expression of heme oxygenase (HO)-1.	Radium	19-21	heme oxygenase 1	Mus musculus	114-135
34831223-6	2021	Recent findings suggest that the IL-4 and IL-13 might play a significant role in the downregulation of inflammatory processes underlying RA pathology, and beneficially modulate the course of the disease.	Radium	137-139	interleukin 4	Homo sapiens	33-37
34831223-6	2021	Recent findings suggest that the IL-4 and IL-13 might play a significant role in the downregulation of inflammatory processes underlying RA pathology, and beneficially modulate the course of the disease.	Radium	137-139	interleukin 13	Homo sapiens	42-47
34717033-0	2021	CDK7 is essential for spermatogenesis by regulating RA signaling pathways and the STAT3 molecular pathway.	Radium	52-54	cyclin-dependent kinase 7	Mus musculus	0-4
34717033-4	2021	Inhibition of CDK7 activity affected spermatogonia proliferation and differentiation, and we found that CDK7 regulates RA-mediated c-KIT expression to play a role in spermatogonia.	Radium	119-121	cyclin-dependent kinase 7	Mus musculus	104-108
34717033-4	2021	Inhibition of CDK7 activity affected spermatogonia proliferation and differentiation, and we found that CDK7 regulates RA-mediated c-KIT expression to play a role in spermatogonia.	Radium	119-121	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	131-136
34717033-5	2021	Then, we demonstrated that inhibition of CDK7 affected meiosis initiation, DNA repair and synaptonemal complex formation in meiosis progression, and CDK7 played this role by regulating RA-mediated STRA8 and REC8 signaling pathways.	Radium	185-187	cyclin-dependent kinase 7	Mus musculus	41-45
34717033-5	2021	Then, we demonstrated that inhibition of CDK7 affected meiosis initiation, DNA repair and synaptonemal complex formation in meiosis progression, and CDK7 played this role by regulating RA-mediated STRA8 and REC8 signaling pathways.	Radium	185-187	cyclin-dependent kinase 7	Mus musculus	149-153
34717033-5	2021	Then, we demonstrated that inhibition of CDK7 affected meiosis initiation, DNA repair and synaptonemal complex formation in meiosis progression, and CDK7 played this role by regulating RA-mediated STRA8 and REC8 signaling pathways.	Radium	185-187	stimulated by retinoic acid gene 8	Mus musculus	197-202
34717033-5	2021	Then, we demonstrated that inhibition of CDK7 affected meiosis initiation, DNA repair and synaptonemal complex formation in meiosis progression, and CDK7 played this role by regulating RA-mediated STRA8 and REC8 signaling pathways.	Radium	185-187	REC8 meiotic recombination protein	Mus musculus	207-211
34893097-3	2021	Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were used to detect the expression level of mRNA and the protein in K562 and K562/ADM cells, and the effect of RA on the expression of MDR1 mRNA and P-gp in K562/ADM cells was also detected; Western blot was used to detect the expression of p-JNK, p-p38 and p-ERK1/2 in K562/ADM cells.	Radium	185-187	ATP binding cassette subfamily B member 1	Homo sapiens	209-213
34893097-6	2021	In addition, RA could upregulate the phosphorylation levels of p38 and ERK1/2 in K562/ADM cells, but it has no effect on the expression of p-JNK.	Radium	13-15	mitogen-activated protein kinase 1	Homo sapiens	63-66
34893097-6	2021	In addition, RA could upregulate the phosphorylation levels of p38 and ERK1/2 in K562/ADM cells, but it has no effect on the expression of p-JNK.	Radium	13-15	mitogen-activated protein kinase 3	Homo sapiens	71-77
34893097-7	2021	CONCLUSION: RA may participate in the regulation of MAPK signaling pathway by upregulating the expression levels of p-p38 and p-ERK1/2 in K562/ADM cells, and thus inhibit the transcription and translation levels of MDR1, and finally reverse the multidrug resistance of leukemia cells.	Radium	12-14	mitogen-activated protein kinase 3	Homo sapiens	52-56
34893097-7	2021	CONCLUSION: RA may participate in the regulation of MAPK signaling pathway by upregulating the expression levels of p-p38 and p-ERK1/2 in K562/ADM cells, and thus inhibit the transcription and translation levels of MDR1, and finally reverse the multidrug resistance of leukemia cells.	Radium	12-14	mitogen-activated protein kinase 1	Homo sapiens	118-121
34893097-7	2021	CONCLUSION: RA may participate in the regulation of MAPK signaling pathway by upregulating the expression levels of p-p38 and p-ERK1/2 in K562/ADM cells, and thus inhibit the transcription and translation levels of MDR1, and finally reverse the multidrug resistance of leukemia cells.	Radium	12-14	mitogen-activated protein kinase 3	Homo sapiens	128-134
34893097-7	2021	CONCLUSION: RA may participate in the regulation of MAPK signaling pathway by upregulating the expression levels of p-p38 and p-ERK1/2 in K562/ADM cells, and thus inhibit the transcription and translation levels of MDR1, and finally reverse the multidrug resistance of leukemia cells.	Radium	12-14	ATP binding cassette subfamily B member 1	Homo sapiens	215-219
34775781-12	2022	These data support combined SGLT2 inhibitor and GLP-1 RA therapy in type 2 diabetes.	Radium	54-56	glucagon like peptide 1 receptor	Homo sapiens	48-53
34827649-0	2021	Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?	Radium	142-144	paired box 6	Homo sapiens	130-134
34768078-0	2021	Corrigendum to SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation (Stem Cell Res/ Apr;44 / 2020 /101771).	Radium	104-106	sirtuin 1	Mus musculus	15-20
34768078-0	2021	Corrigendum to SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation (Stem Cell Res/ Apr;44 / 2020 /101771).	Radium	104-106	Rab40B, member RAS oncogene family	Mus musculus	115-118
34768078-0	2021	Corrigendum to SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation (Stem Cell Res/ Apr;44 / 2020 /101771).	Radium	104-106	nuclear receptor co-repressor 1	Mus musculus	134-139
34736346-9	2022	The threshold value of surface roughness for a rapid increase in the degradation of HMW-VWF under low flow rate was obtained between Ra 0.4 and 0.6 mum, which was smaller than the threshold for hemolysis.	Radium	133-135	cilia and flagella associated protein 97	Homo sapiens	84-87
34736346-9	2022	The threshold value of surface roughness for a rapid increase in the degradation of HMW-VWF under low flow rate was obtained between Ra 0.4 and 0.6 mum, which was smaller than the threshold for hemolysis.	Radium	133-135	von Willebrand factor	Homo sapiens	88-91
34474187-13	2021	In addition, 29 signaling pathways were found to be involved in RA-RRM-induced amelioration, including the NF-kappaB, TNF, TGF-beta, VEGF, and HIF-1 signaling pathways, using KEGG analysis.	Radium	64-66	transforming growth factor alpha	Homo sapiens	123-131
34474187-13	2021	In addition, 29 signaling pathways were found to be involved in RA-RRM-induced amelioration, including the NF-kappaB, TNF, TGF-beta, VEGF, and HIF-1 signaling pathways, using KEGG analysis.	Radium	64-66	vascular endothelial growth factor A	Homo sapiens	133-137
34474187-13	2021	In addition, 29 signaling pathways were found to be involved in RA-RRM-induced amelioration, including the NF-kappaB, TNF, TGF-beta, VEGF, and HIF-1 signaling pathways, using KEGG analysis.	Radium	64-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-148
34474187-13	2021	In addition, 29 signaling pathways were found to be involved in RA-RRM-induced amelioration, including the NF-kappaB, TNF, TGF-beta, VEGF, and HIF-1 signaling pathways, using KEGG analysis.	Radium	64-66	tumor necrosis factor	Homo sapiens	118-121
34745006-8	2021	The cardio- and reno-protective effects of GLP-1-RA are at least in part related to the interaction with RAAS.	Radium	49-51	glucagon like peptide 1 receptor	Homo sapiens	43-48
34540008-10	2021	RAS and ARAS increased systemic levels of tumor necrosis factor (TNF)-alpha, which were further elevated in MetS + RAS.	Radium	0-3	tumor necrosis factor	Sus scrofa	42-75
34417575-8	2021	ATRA and the retinoid X receptor (RXR) agonists 9-cis RA and LG100268 induced the gene expression of Srebp-1c, which was almost completely abolished by the RXR antagonist HX531.	Radium	54-56	sterol regulatory element binding transcription factor 1	Rattus norvegicus	101-109
34461118-6	2021	The investigation of the mechanism of mTORC2 inhibition showed that simvastatin impaired Ras farnesylation, which was prevented by farnesol but without restoring mTORC2 activity.	Radium	89-92	CREB regulated transcription coactivator 2	Mus musculus	38-44
34115201-10	2021	RESULTS: The dentifrices placebo and NaF in the low flow presented lower SMH and higher Ra in T3 and lower Ca% compared to the same dentifrices in normal flow.	Radium	88-90	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
34237409-10	2021	The Dox@mPH-RA increased the levels of apoptosis markers, caspase 3, 7, Ki-67, and caused the highest DNA fragmentation.	Radium	12-14	caspase 3	Homo sapiens	58-67
34166781-8	2021	Hence, we speculate that Meg3 has a role in the RA-induced suppression of MEPM cell proliferation by targeting Smad2 and thereby mediating TGF-beta/Smad signaling inhibition.	Radium	48-50	SMAD family member 2	Mus musculus	111-116
34166781-8	2021	Hence, we speculate that Meg3 has a role in the RA-induced suppression of MEPM cell proliferation by targeting Smad2 and thereby mediating TGF-beta/Smad signaling inhibition.	Radium	48-50	transforming growth factor alpha	Mus musculus	139-147
34446849-7	2021	Secondary endpoints included the time to pain progression (TPP) and Total FACT-P deterioration (TTFD), defined as time from first Ra-223 treatment to clinical meaningful increase in BPI-SF Worst pain item score and Total FACT-P score, respectively.	Radium	130-132	bactericidal permeability increasing protein	Homo sapiens	182-185
34236045-0	2021	JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer.	Radium	63-66	jun D proto-oncogene	Mus musculus	0-4
34217774-1	2021	AIM: We evaluated the effect of the latest GLP-1 RA semaglutide on tongue fat storage in obese women.	Radium	49-51	glucagon like peptide 1 receptor	Homo sapiens	43-48
34217774-1	2021	AIM: We evaluated the effect of the latest GLP-1 RA semaglutide on tongue fat storage in obese women.	Radium	49-51	FAT atypical cadherin 1	Homo sapiens	74-77
34356659-9	2021	The renin-angiotensin (RA) system affects the inflammatory process by increasing the IL-6 level.	Radium	23-25	interleukin 6	Homo sapiens	85-89
34236045-0	2021	JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer.	Radium	63-66	jun proto-oncogene	Mus musculus	24-28
34236045-7	2021	This work identifies JunD, not c-Jun, as the crucial substrate of JNK signaling and oncogene required for Ras-induced lung cancer.	Radium	106-109	jun D proto-oncogene	Mus musculus	21-25
34236045-7	2021	This work identifies JunD, not c-Jun, as the crucial substrate of JNK signaling and oncogene required for Ras-induced lung cancer.	Radium	106-109	mitogen-activated protein kinase 8	Mus musculus	66-69
34160821-7	2021	As pharmacists are called to counsel patients on TPO-RA use, a deep understanding of potential adverse events and management strategies, as well as appropriate monitoring, will increase the likelihood that patients meet their goals of therapy in the shortest timeframe.	Radium	53-55	thyroid peroxidase	Homo sapiens	49-52
34356620-4	2021	We propose a molecular model in which Ras binding is involved in the release of Raf autoinhibition while the Ras-Raf complex dimerizes to promote a platform for signal amplification, with Raf-CRD centrally located to impact regulation and function.	Radium	38-41	zinc fingers and homeoboxes 2	Homo sapiens	80-83
34356620-4	2021	We propose a molecular model in which Ras binding is involved in the release of Raf autoinhibition while the Ras-Raf complex dimerizes to promote a platform for signal amplification, with Raf-CRD centrally located to impact regulation and function.	Radium	38-41	zinc fingers and homeoboxes 2	Homo sapiens	188-191
34098057-1	2021	AIM: Previous studies have found reduced concentrations of both leptin and resistin after glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatment; however, the evidence in this field is inconclusive.	Radium	138-140	leptin	Homo sapiens	64-70
34098057-1	2021	AIM: Previous studies have found reduced concentrations of both leptin and resistin after glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatment; however, the evidence in this field is inconclusive.	Radium	138-140	glucagon like peptide 1 receptor	Homo sapiens	90-122
34079225-4	2021	Romiplostim is a TPO-RA approved for use in patients with ITP in the United States, European Union, Australia, and several countries in Africa and Asia, as well as for use in patients with refractory aplastic anemia in Japan and Korea.	Radium	21-23	thrombopoietin	Homo sapiens	17-20
34098057-1	2021	AIM: Previous studies have found reduced concentrations of both leptin and resistin after glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatment; however, the evidence in this field is inconclusive.	Radium	138-140	glucagon like peptide 1 receptor	Homo sapiens	132-137
34098057-8	2021	CONCLUSION: The results of this meta-analysis of randomized controlled trials suggest that GLP-1 RA therapy reduces both leptin and resistin levels.	Radium	97-99	glucagon like peptide 1 receptor	Homo sapiens	91-96
34098057-8	2021	CONCLUSION: The results of this meta-analysis of randomized controlled trials suggest that GLP-1 RA therapy reduces both leptin and resistin levels.	Radium	97-99	leptin	Homo sapiens	121-127
34135013-7	2021	The 60-day mortality was 3.11% (387 of 12,446), with 2.06% (138 of 6,692) for GLP1-RA use, 2.32% (85 of 3,665) for SGLT2i use, and 5.67% (199 of 3,511) for DPP4i use.	Radium	83-85	glucagon like peptide 1 receptor	Homo sapiens	78-82
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	developmental pluripotency-associated 3	Mus musculus	61-67
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	deleted in azoospermia-like	Mus musculus	69-73
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	stimulated by retinoic acid gene 8	Mus musculus	75-80
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	synaptonemal complex protein 3	Mus musculus	82-87
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	growth differentiation factor 9	Mus musculus	93-97
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	POU domain, class 5, transcription factor 1	Mus musculus	132-136
34475317-4	2021	RA-treated cells exhibited increased expression of Fragilis, Stella, Dazl, Stra8, Sycp3, and Gdf9 genes and decreased expression of Oct4, Mvh genes compared to the non-treated controls.	Radium	0-2	DEAD box helicase 4	Mus musculus	138-141
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	POU domain, class 5, transcription factor 1	Mus musculus	87-91
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	developmental pluripotency-associated 3	Mus musculus	103-109
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	deleted in azoospermia-like	Mus musculus	111-115
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	synaptonemal complex protein 3	Mus musculus	117-122
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	growth differentiation factor 9	Mus musculus	124-128
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	DEAD box helicase 4	Mus musculus	157-160
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	13-15	stimulated by retinoic acid gene 8	Mus musculus	166-171
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	POU domain, class 5, transcription factor 1	Mus musculus	87-91
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	developmental pluripotency-associated 3	Mus musculus	103-109
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	deleted in azoospermia-like	Mus musculus	111-115
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	synaptonemal complex protein 3	Mus musculus	117-122
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	growth differentiation factor 9	Mus musculus	124-128
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	DEAD box helicase 4	Mus musculus	157-160
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	50-52	stimulated by retinoic acid gene 8	Mus musculus	166-171
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	194-196	POU domain, class 5, transcription factor 1	Mus musculus	87-91
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	194-196	developmental pluripotency-associated 3	Mus musculus	103-109
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	194-196	DEAD box helicase 4	Mus musculus	157-160
34475317-5	2021	Furthermore, RA in combination with progesterone (RA?P) led to increased expression of Oct4, Fragilis, Stella, Dazl, Sycp3, Gdf9 and decreased expression of Mvh, and Stra8 genes compared to the RA-treated scenario.	Radium	194-196	stimulated by retinoic acid gene 8	Mus musculus	166-171
35522243-3	2022	Analysis of transcriptomic data identified a JAK2 related JAK/STAT signaling pathway gene signature that distinguishes RA-UIP from idiopathic UIP.	Radium	119-121	Janus kinase 2	Homo sapiens	45-49
35522243-3	2022	Analysis of transcriptomic data identified a JAK2 related JAK/STAT signaling pathway gene signature that distinguishes RA-UIP from idiopathic UIP.	Radium	119-121	Janus kinase 2	Homo sapiens	58-61
35584281-6	2022	However, long-term treatment with 9-cis RA resulted in decreased overall tail volume, dermal thickness, and epidermal thickness, with an associated increase in functional lymphatic clearance and lymphatic vessel density, assessed by LYVE-1 immunostaining, compared with control.	Radium	40-42	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	233-239
35134170-3	2022	However, the role of angiotensin II and other vasoactive hormones on GLP-1 RA treatment has not been clearly defined.	Radium	75-77	glucagon like peptide 1 receptor	Homo sapiens	69-74
35194917-6	2022	The overall analysis results showed that GLP-1 RA improved glycemic control without increasing the risk of hypoglycemic events.	Radium	47-49	glucagon like peptide 1 receptor	Homo sapiens	41-46
35598398-9	2022	Next, we identified the downstream signaling pathway of CD147, and proved that the anti-RA effects of GEN were mediated by down-regulating the expression of p38, IkappaBalpha and p65 in vivo and in vitro assays.	Radium	88-90	basigin	Mus musculus	56-61
35598398-9	2022	Next, we identified the downstream signaling pathway of CD147, and proved that the anti-RA effects of GEN were mediated by down-regulating the expression of p38, IkappaBalpha and p65 in vivo and in vitro assays.	Radium	88-90	mitogen-activated protein kinase 14	Mus musculus	157-160
35598398-9	2022	Next, we identified the downstream signaling pathway of CD147, and proved that the anti-RA effects of GEN were mediated by down-regulating the expression of p38, IkappaBalpha and p65 in vivo and in vitro assays.	Radium	88-90	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	162-174
35598398-9	2022	Next, we identified the downstream signaling pathway of CD147, and proved that the anti-RA effects of GEN were mediated by down-regulating the expression of p38, IkappaBalpha and p65 in vivo and in vitro assays.	Radium	88-90	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	179-182
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	thymoma viral proto-oncogene 1	Mus musculus	141-144
35609420-6	2022	A filter binding assay demonstrated that RA-VII markedly enhances the binding affinity of eEF2 for GTP, but not for GDP, and prevents exchange of GTP in the eEF2-GTP complex, even after addition of a large excess of GTP/GDP.	Radium	41-43	eukaryotic translation elongation factor 2	Homo sapiens	90-94
35609420-6	2022	A filter binding assay demonstrated that RA-VII markedly enhances the binding affinity of eEF2 for GTP, but not for GDP, and prevents exchange of GTP in the eEF2-GTP complex, even after addition of a large excess of GTP/GDP.	Radium	41-43	eukaryotic translation elongation factor 2	Homo sapiens	157-161
35609420-9	2022	These results suggest that RA-VII tightly stabilizes the GTP eEF2 complex structure, which is able to bind to the ribosomal functional site, but seems to suppress normal turnover of eEF2 after translocation.	Radium	27-29	eukaryotic translation elongation factor 2	Homo sapiens	61-65
35609420-9	2022	These results suggest that RA-VII tightly stabilizes the GTP eEF2 complex structure, which is able to bind to the ribosomal functional site, but seems to suppress normal turnover of eEF2 after translocation.	Radium	27-29	eukaryotic translation elongation factor 2	Homo sapiens	182-186
35609420-10	2022	The properties of RA-VII make it a novel ligand for probing the action of eEF2 in the process of translocation on the ribosome.	Radium	18-21	eukaryotic translation elongation factor 2	Homo sapiens	74-78
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	signal transducer and activator of transcription 3	Mus musculus	146-151
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	signal transducer and activator of transcription 3	Mus musculus	154-159
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	161-167
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	glycogen synthase kinase 3 alpha	Mus musculus	183-191
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	225-231
35491520-9	2022	Further research into the effect of adding Gla-300 to GLP-1 RA therapy is warranted.	Radium	60-62	glucagon like peptide 1 receptor	Homo sapiens	54-59
35124150-8	2022	The results showed that on day 10 of RA-induction, grape cluster growth cells expressed integrinbeta1, the specific marker protein of SSCs cells, and the integrinbeta1 positive rate was 35.1%.	Radium	37-39	integrin subunit beta 1	Gallus gallus	88-101
35373878-4	2022	During follow-up, 673 participants receiving GLP-1 RA treatment (8.7%) and 416 participants receiving placebo (11.2%) had a cardiovascular event.	Radium	51-53	glucagon like peptide 1 receptor	Homo sapiens	45-50
35124150-8	2022	The results showed that on day 10 of RA-induction, grape cluster growth cells expressed integrinbeta1, the specific marker protein of SSCs cells, and the integrinbeta1 positive rate was 35.1%.	Radium	37-39	integrin subunit beta 1	Gallus gallus	154-167
35124150-9	2022	Also, SSCs marker genes CVH, Integrinbeta1, Integrinalpha6 were significantly up-regulated during RA-induction.	Radium	98-100	DEAD-box helicase 4	Gallus gallus	24-27
35124150-9	2022	Also, SSCs marker genes CVH, Integrinbeta1, Integrinalpha6 were significantly up-regulated during RA-induction.	Radium	98-100	integrin subunit beta 1	Gallus gallus	29-42
35124150-9	2022	Also, SSCs marker genes CVH, Integrinbeta1, Integrinalpha6 were significantly up-regulated during RA-induction.	Radium	98-100	integrin subunit alpha 6	Gallus gallus	44-58
35124150-12	2022	The qRT-PCR results showed that the expression levels of RA receptors (RXRA, RARA and RXRG) and the predicted genes (COL5A1, COL5A2 and COL3A1) were both significantly increased during RA-induction.	Radium	185-187	retinoid X receptor alpha	Gallus gallus	71-75
35124150-12	2022	The qRT-PCR results showed that the expression levels of RA receptors (RXRA, RARA and RXRG) and the predicted genes (COL5A1, COL5A2 and COL3A1) were both significantly increased during RA-induction.	Radium	185-187	retinoid X receptor gamma	Gallus gallus	86-90
35124150-12	2022	The qRT-PCR results showed that the expression levels of RA receptors (RXRA, RARA and RXRG) and the predicted genes (COL5A1, COL5A2 and COL3A1) were both significantly increased during RA-induction.	Radium	185-187	collagen type V alpha 1 chain	Gallus gallus	117-123
35124150-12	2022	The qRT-PCR results showed that the expression levels of RA receptors (RXRA, RARA and RXRG) and the predicted genes (COL5A1, COL5A2 and COL3A1) were both significantly increased during RA-induction.	Radium	185-187	collagen type V alpha 2 chain	Gallus gallus	125-131
35124150-12	2022	The qRT-PCR results showed that the expression levels of RA receptors (RXRA, RARA and RXRG) and the predicted genes (COL5A1, COL5A2 and COL3A1) were both significantly increased during RA-induction.	Radium	185-187	collagen type III alpha 1 chain	Gallus gallus	136-142
35124150-13	2022	Also, dual-luciferase reporter assay showed that RA could affect the luciferin activities of COL5A1, COL5A2 and COL3A1.	Radium	49-51	collagen type V alpha 1 chain	Gallus gallus	93-99
35124150-13	2022	Also, dual-luciferase reporter assay showed that RA could affect the luciferin activities of COL5A1, COL5A2 and COL3A1.	Radium	49-51	collagen type V alpha 2 chain	Gallus gallus	101-107
35124150-13	2022	Also, dual-luciferase reporter assay showed that RA could affect the luciferin activities of COL5A1, COL5A2 and COL3A1.	Radium	49-51	collagen type III alpha 1 chain	Gallus gallus	112-118
35124150-14	2022	These results suggest that RA plays a crucial role in the formation of chicken spermatogonial stem cells via the transcription levels of COL5A1, COL5A2 and COL3A1 to regulate the ECM-receptor interaction signaling pathway.	Radium	27-29	collagen type V alpha 1 chain	Gallus gallus	137-143
35124150-14	2022	These results suggest that RA plays a crucial role in the formation of chicken spermatogonial stem cells via the transcription levels of COL5A1, COL5A2 and COL3A1 to regulate the ECM-receptor interaction signaling pathway.	Radium	27-29	collagen type V alpha 2 chain	Gallus gallus	145-151
35124150-14	2022	These results suggest that RA plays a crucial role in the formation of chicken spermatogonial stem cells via the transcription levels of COL5A1, COL5A2 and COL3A1 to regulate the ECM-receptor interaction signaling pathway.	Radium	27-29	collagen type III alpha 1 chain	Gallus gallus	156-162
35123846-6	2022	Prostate-specific antigen significantly increased from baseline in patients who received radium-223 as third-line treatment and in patients who received radium-223 post-chemotherapy.	Radium	89-95	kallikrein related peptidase 3	Homo sapiens	0-25
35007700-3	2022	Patients in the intervention group were required to receive TPO-RA therapy.	Radium	64-66	thyroid peroxidase	Homo sapiens	60-63
35007700-6	2022	More thromboembolic events were noted in the TPO-RA group than in the control group: 25 compared to 4.	Radium	49-51	thyroid peroxidase	Homo sapiens	45-48
35007700-10	2022	Our findings indicate there is a non-significant higher chance of thrombosis in ITP patients with TPO-RA treatments versus ITP patients without TPO-RA treatment.	Radium	102-104	thyroid peroxidase	Homo sapiens	98-101
35007700-10	2022	Our findings indicate there is a non-significant higher chance of thrombosis in ITP patients with TPO-RA treatments versus ITP patients without TPO-RA treatment.	Radium	148-150	thyroid peroxidase	Homo sapiens	144-147
35185331-10	2022	The TZ-containing BMPs all can be targeted to and internalized in the HER2-overexpressing breast cancer cell line SK-BR-3; however, their targeting efficiencies vary considerably: 50-75% for RA-TZ-containing BMPs and 9-19% for GA-TZ-containing BMPs.	Radium	191-193	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-74
35175551-7	2022	Here, we review evidence on GLP-1 RA use in people living with T2DM and CKD and summarize renal outcomes from clinical studies.	Radium	34-36	glucagon like peptide 1 receptor	Homo sapiens	28-33
35297184-4	2022	Owing to this unique chemical structure, HNG-ethanol exhibits superior gas sensing properties toward NO gas (Ra /Rg  = 3.05, 20 ppm) with a practical limit of detection (LOD) of 500 ppb and reliable repeatability (over 5 cycles).	Radium	109-111	neurogranin	Homo sapiens	41-44
35371812-13	2022	Regarding TPO-RA treatment for refractory ITP during pregnancy, only six pregnant cases including the present one treated with eltrombopag have been reported so far.	Radium	14-16	thyroid peroxidase	Homo sapiens	10-13
35222806-8	2022	A dual-luciferase reporter assay exhibited that miR-155-5p could inhibit the Ras homolog enriched in brain (Rheb) expression, a mechanism critical for miR-155-5p-mediated neuronal injury.	Radium	77-80	microRNA 155	Mus musculus	48-55
35222806-8	2022	A dual-luciferase reporter assay exhibited that miR-155-5p could inhibit the Ras homolog enriched in brain (Rheb) expression, a mechanism critical for miR-155-5p-mediated neuronal injury.	Radium	77-80	Ras homolog enriched in brain	Mus musculus	108-112
35222806-8	2022	A dual-luciferase reporter assay exhibited that miR-155-5p could inhibit the Ras homolog enriched in brain (Rheb) expression, a mechanism critical for miR-155-5p-mediated neuronal injury.	Radium	77-80	microRNA 155	Mus musculus	151-158
35123846-6	2022	Prostate-specific antigen significantly increased from baseline in patients who received radium-223 as third-line treatment and in patients who received radium-223 post-chemotherapy.	Radium	153-159	kallikrein related peptidase 3	Homo sapiens	0-25
35078985-3	2022	In both autoinhibited, monomeric structures, the RAS binding domain (RBD) of BRAF is resolved, revealing that the RBD forms an extensive contact interface with the 14-3-3 protomer bound to the BRAF C-terminal site and that key basic residues required for RBD-RAS binding are exposed.	Radium	49-52	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	77-81
35078985-3	2022	In both autoinhibited, monomeric structures, the RAS binding domain (RBD) of BRAF is resolved, revealing that the RBD forms an extensive contact interface with the 14-3-3 protomer bound to the BRAF C-terminal site and that key basic residues required for RBD-RAS binding are exposed.	Radium	49-52	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	164-170
35078985-3	2022	In both autoinhibited, monomeric structures, the RAS binding domain (RBD) of BRAF is resolved, revealing that the RBD forms an extensive contact interface with the 14-3-3 protomer bound to the BRAF C-terminal site and that key basic residues required for RBD-RAS binding are exposed.	Radium	49-52	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	193-197
35054349-12	2022	CONCLUSION: In anti-IL-6R RA-treated patients, hsCRP does not reflect the inflammatory disease state, but in those treated with JAKi, hsCRP was associated with US synovitis.	Radium	26-28	interleukin 6 receptor	Homo sapiens	20-25
35059245-6	2022	Forty-six percent of the subjects in the daily GLP-1 RAs group reported that the incidence of forgetting injections of GLP-1 RA was decreased.	Radium	125-127	glucagon like peptide 1 receptor	Homo sapiens	47-52
34997102-9	2022	High baseline HbA1c, the addition of GLP-1 RA treatment modality, and in-hospital initiation of GLP-1 RA treatment were identified as significant contributing factors to HbA1c reduction.	Radium	102-104	glucagon like peptide 1 receptor	Homo sapiens	96-101
35101924-4	2022	RESEARCH DESIGN AND METHODS: A retrospective cohort study among patients with T2DM initiating injectable GLP-1 RA therapy was conducted using the Clinical Practice Research Datalink that includes primary care medical records for 13 million patients in the UK.	Radium	111-113	glucagon like peptide 1 receptor	Homo sapiens	105-110
34225640-3	2022	We have previously demonstrated that Ra-SBRT ablates metastatic lesions and induces tumor immune rejection of metastatic tumors by promoting in situ programming of M2 TAM towards M1-TAM and infiltration of Siglec-8+ Eosinophils.	Radium	37-39	sialic acid binding Ig like lectin 8	Homo sapiens	206-214
35059245-6	2022	Forty-six percent of the subjects in the daily GLP-1 RAs group reported that the incidence of forgetting injections of GLP-1 RA was decreased.	Radium	125-127	glucagon like peptide 1 receptor	Homo sapiens	119-124
2602914-4	1989	Addition of RA-SF to LPS-pretreated cell cultures results in IgG2b secretion in CBA/N spleen cells as well.	Radium	12-14	immunoglobulin heavy constant gamma 2B	Mus musculus	61-66
2784801-2	1989	RA is associated with decreased IL 2 production.	Radium	0-2	interleukin 2	Homo sapiens	32-36
2548190-3	1989	Nuclear extracts prepared from COS-1 cells transfected with an expression vector for the nuclear RA receptors RAR alpha or RAR beta were enriched (20- to 100-fold) with a RA-binding activity that coeluted by size-exclusion HPLC with the putative RAR from HL-60 cells.	Radium	97-99	retinoic acid receptor alpha	Homo sapiens	110-119
2548190-3	1989	Nuclear extracts prepared from COS-1 cells transfected with an expression vector for the nuclear RA receptors RAR alpha or RAR beta were enriched (20- to 100-fold) with a RA-binding activity that coeluted by size-exclusion HPLC with the putative RAR from HL-60 cells.	Radium	97-99	retinoic acid receptor beta	Homo sapiens	123-131
2656343-4	1989	However, under isotopic non-steady-state conditions, the isotopically determined Ra was significantly lower than the glucose infusion rate (11.5 +/- 1.3 vs. 13.7 +/- 1.5 mg.kg-1 fat-free mass.min-1, respectively, P less than .001), and the underestimation was related to the deviation from the isotopic steady state.	Radium	81-83	CD59 molecule (CD59 blood group)	Homo sapiens	192-197
2563199-6	1989	Insulin further increased Rd (+76%), Glucox (+155%), and Glucnonox (+50%) but decreased Ra (-43%) and Lipox (-43%).	Radium	88-90	insulin	Homo sapiens	0-7
2787055-6	1989	By the method, anti-Ro/SSA antibodies were detected in SLE (44%), MCTD (71%), PSS (50%), SjS (83%), RA (16%), PBC (23%), lupoid hepatitis (23%) but only 4% in normal controls.	Radium	100-102	tripartite motif containing 21	Homo sapiens	20-26
2698356-4	1989	In study I, Ra was normalized within 45 min after insulin supply but Rd increased transiently before returning to normal.	Radium	12-14	insulin	Canis lupus familiaris	50-57
2573982-4	1989	CONCLUSION: A desensitization of soluble guanylate cyclase to activation with NO can be demonstrated under non-physiological conditions (disrupted cells) in homogenates from nitrate tolerant RA.	Radium	191-193	guanylate cyclase	Bos taurus	41-58
3233185-5	1988	An increase in both the concentrations of plasma retinol and RBP were detected after topical application of the RA gel.	Radium	112-114	retinol binding protein 4	Homo sapiens	61-64
2977197-12	1988	Much more ANP may be produced from RA in long-standing mitral valve disease.	Radium	35-37	natriuretic peptide A	Homo sapiens	10-13
3067866-7	1988	Genes on chromosome 14 may also influence susceptibility to RA, probably by interaction with MHC genes and there are different Gm associations for DR4-positive and collagen-antibody-positive rheumatoid subgroups.	Radium	60-62	major histocompatibility complex, class I, C	Homo sapiens	93-96
3067866-7	1988	Genes on chromosome 14 may also influence susceptibility to RA, probably by interaction with MHC genes and there are different Gm associations for DR4-positive and collagen-antibody-positive rheumatoid subgroups.	Radium	60-62	major histocompatibility complex, class II, DR beta 4	Homo sapiens	147-150
3148711-3	1988	SF from active RA contained a significant amount of IL-1 beta and IL-2 but not gamma-IFN.	Radium	15-17	interleukin 1 beta	Homo sapiens	52-61
3056958-8	1988	In addition, incubation of MTLn3 cells with 50 microM RA 233 resulted in an increase of p21ras protein expression, whereas there was no effect on the level of p21ras in identically treated MTC cells or when either clone was treated with 10 ng/ml EGF.	Radium	54-56	HRas proto-oncogene, GTPase	Rattus norvegicus	88-94
3148711-3	1988	SF from active RA contained a significant amount of IL-1 beta and IL-2 but not gamma-IFN.	Radium	15-17	interleukin 2	Homo sapiens	66-70
3658705-1	1987	Raman spectra of gp5 and complexes of gp5 with poly(rA) and poly(dA) have been determined and analysed.	Radium	52-54	glycoprotein V platelet	Homo sapiens	17-20
2898893-2	1988	Without adrenergic blockade, infusion of insulin at 0.275 mU.kg-1.min-1 (control) caused glucose to fall from 92 +/- 4 to 82 +/- 4 mg/dl over 30 min, because of transient fall in Ra from 2.8 +/- 0.4 to 2.3 +/- 0.3 mg.kg-1.min-1, which recovered to base line by 30 min.	Radium	179-181	insulin	Canis lupus familiaris	41-48
3658705-1	1987	Raman spectra of gp5 and complexes of gp5 with poly(rA) and poly(dA) have been determined and analysed.	Radium	52-54	glycoprotein V platelet	Homo sapiens	38-41
3658705-5	1987	Binding of gp5 to poly(rA) and poly(dA) influences the intensity of bands near 1338 and 1480 cm-1 which are considered to be marker-bands for the phosphate-sugar-base conformer.	Radium	23-25	glycoprotein V platelet	Homo sapiens	11-14
3658705-8	1987	It seems that gp5 forces poly(rA) and poly(dA) to a similar conformation.	Radium	30-32	glycoprotein V platelet	Homo sapiens	14-17
2821650-6	1987	Similar blockade of the inhibitory actions of several other inhibitors of cAMP PDE such as RA 233, RX-RA 69 (analogs of dipyridamole) and oxagrelate is seen by adenosine deaminase pretreatment.	Radium	91-93	adenosine deaminase	Homo sapiens	160-179
3476218-3	1987	The occurrence of these processes was much greater in RA-treated THP-1-Cs5 cells than in RA-treated THP-1-R cells.	Radium	54-56	GLI family zinc finger 2	Homo sapiens	65-70
3476218-3	1987	The occurrence of these processes was much greater in RA-treated THP-1-Cs5 cells than in RA-treated THP-1-R cells.	Radium	89-91	GLI family zinc finger 2	Homo sapiens	100-105
3476218-5	1987	Morphological changes in RA-treated THP-1-Cs5 cells were observed by light and electron microscopy.	Radium	25-27	GLI family zinc finger 2	Homo sapiens	36-41
3476218-7	1987	Among various retinoids examined, RA was the strongest inducer of the differentiation of the THP-1-Cs5 cells into mature cells.	Radium	34-36	GLI family zinc finger 2	Homo sapiens	93-98
3029143-9	1987	By contrast, similar extracts from Nulli-SCC1 cells treated with retinol bound large amounts of both [3H]retinol and [3H]RA.	Radium	121-123	protein tyrosine phosphatase, receptor type, J	Mus musculus	41-45
3487336-8	1986	HNK-1+ cell percentage resulted only slightly reduced in patients with RA (13.1 +/- 8.7 versus 15.0 +/- 7.0) and there was only a modest correlation (p approximately equal to 0.10) between NK activity and HNK-1+ cell percentage.	Radium	71-73	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
3029143-1	1987	[3H]Retinoic acid (RA) and [3H]retinol bind in an unsaturable manner to isolated nuclei from Nulli-SCC1 and PCC4.aza1R embryonal carcinoma (EC) cells.	Radium	19-21	protein tyrosine phosphatase, receptor type, J	Mus musculus	99-103
3029143-8	1987	Nucleoplasmic extracts from Nulli-SCC1 and PCC4.aza1R cells pretreated with RA had considerable levels of specific [3H]RA-binding activity with little or no increase in [3H]retinol binding.	Radium	76-78	protein tyrosine phosphatase, receptor type, J	Mus musculus	34-38
3502559-6	1986	Conversely, the combination of the presence of HLA-Dw2, B27, and older age of onset of disease was found to be the most powerful predictor of the development of cervical spine changes and successfully predicted this complication of RA in 73 per cent.	Radium	232-234	melanocortin 2 receptor accessory protein	Homo sapiens	56-59
3946853-9	1986	Ao-RA end diastolic gradients decreased in four of the five during SCV-CPR.	Radium	3-5	cytochrome p450 oxidoreductase	Homo sapiens	71-74
3501431-7	1987	In the presence of RA, particularly trans-RA, medial epithelial cells acquired nasal cell characteristics, and EGF enhanced this effect.	Radium	19-21	epidermal growth factor	Mus musculus	111-114
3533684-5	1986	Hepatic glucose production (Ra) was suppressed by greater than 95% during each euglycemic clamp and during the 20-h insulin infusion.	Radium	28-30	insulin	Homo sapiens	116-123
3533684-6	1986	After the insulin infusion, Ra and glucose utilization rate returned to the initial basal level within 1 h, as did insulin levels.	Radium	28-30	insulin	Homo sapiens	10-17
6442470-3	1984	The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor or further deteriorated including coma on admission, the excretion rate of AT III RA was 18.08 +/- 2.50 X 10(-4) ml/min.	Radium	196-198	serpin family C member 1	Homo sapiens	189-195
4031071-6	1985	The difference between the Ra determined by 3-D1-glucose (Ra3) and the Ra determined by 6,6-D2-glucose (Ra6) represents the SCR between fructose-6-phosphate and fructose-1,6-diphosphate.	Radium	27-29	RA3	Homo sapiens	58-61
4031071-6	1985	The difference between the Ra determined by 3-D1-glucose (Ra3) and the Ra determined by 6,6-D2-glucose (Ra6) represents the SCR between fructose-6-phosphate and fructose-1,6-diphosphate.	Radium	27-29	RA6	Homo sapiens	104-107
3881988-8	1985	Tracer-determined basal Ra of insulin was 2.39 +/- (SE) 0.61 mU/min.	Radium	24-26	insulin	Canis lupus familiaris	30-37
3986959-7	1985	Therefore, RA must be present simultaneously with TPA; it presumably acts on the cell surface when antagonizing the effect of TPA on FN release.	Radium	11-13	plasminogen activator, tissue type	Homo sapiens	126-129
3986959-7	1985	Therefore, RA must be present simultaneously with TPA; it presumably acts on the cell surface when antagonizing the effect of TPA on FN release.	Radium	11-13	fibronectin 1	Homo sapiens	133-135
6561390-5	1984	Complexes made with RA Ab bound 18% as much C-1 as those made with native Ab.	Radium	20-22	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	44-47
6540263-4	1984	The pTP X Ad Pol complex utilizes a variety of homopolymer template-primer combinations including poly(dC) X oligo(dG), poly(dA) X oligo(dT), poly(dT) X oligo(dA), and poly(dT) X oligo(rA).	Radium	185-187	protein tyrosine phosphatase receptor type U	Homo sapiens	4-7
6418795-8	1984	These results indicate that B cells responsible for the cognate interaction and those having TRF acceptor site(s) belong to a distinct subpopulation of B cells, and that the cytocidal action of the noncovalent conjugate of the antibody and RA formed from the biotinylated antibody and avidin-RA via an avidin-biotin complex has immunologic selectivity, eliminating only the latter subset of B cells recognized by the antibody.	Radium	240-242	interleukin 5	Mus musculus	93-96
6561390-6	1984	These data indicate that the principal, if not the only, effect of RA is on C-1 binding.	Radium	67-69	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	76-79
6348949-6	1983	We present our initial retrospective results in 28 patients with refractory RA given low dose oral MTX over the past 2.5 yr. An apparent positive response was noted in 19 of these patients (67%) and is similar to the experience of other clinicians.	Radium	76-78	metaxin 1	Homo sapiens	99-102
6580490-8	1983	After IFN-alpha rA in vivo therapy, their NK cells became refractory to further in vitro IFN-alpha rA treatment.	Radium	16-18	interferon alpha 1	Homo sapiens	6-15
7284377-12	1981	2",3"-DideoxyTTP, a potent inhibitor of DNA polymerase beta or gamma, slightly inhibited the reactions with poly(rA) .	Radium	113-115	DNA polymerase beta	Bos taurus	40-59
6132712-4	1983	During euglycaemia 50% inhibition of RA of endogenous glucose occurred at insulin concentrations of 60 microU/ml in arterial plasma.	Radium	37-39	LOC105613195	Ovis aries	74-81
6132712-8	1983	Hypoglycaemia was associated with a reduction in insulin"s suppression of RA of endogenous glucose and hyperglycaemia significantly reduced the increase in MCR due to insulin.	Radium	74-76	LOC105613195	Ovis aries	49-56
6337503-7	1983	Insulin infusion at 0.05 U X kg-1 X h-1 by the peripheral and portal circulations reduced 3H-Ra to the normal range: 3.1 and 2.8 mg X kg-1 X min-1, respectively.	Radium	93-95	insulin	Canis lupus familiaris	0-7
6299278-1	1982	Cellular retinoic acid-binding protein (CRABP) was detected in the nuclear fraction of N-methyl-N-nitrosourea-induced mammary cancers after the incubation of cytosol containing [3H]retinoic acid (RA)-bound CRABP with isolated nuclei.	Radium	41-43	cellular retinoic acid binding protein 1	Homo sapiens	0-38
6299278-1	1982	Cellular retinoic acid-binding protein (CRABP) was detected in the nuclear fraction of N-methyl-N-nitrosourea-induced mammary cancers after the incubation of cytosol containing [3H]retinoic acid (RA)-bound CRABP with isolated nuclei.	Radium	41-43	cellular retinoic acid binding protein 1	Homo sapiens	206-211
6299278-3	1982	[3H]RA-CRABP was found to be a prerequisite for the detection of nuclear binding, since the incubation of isolated nuclei or 0.4 M-KCl extract of the nuclei with [3H]RA did not result in any significant binding.	Radium	4-6	cellular retinoic acid binding protein 1	Homo sapiens	7-12
6185764-1	1982	An enkephalin analogue, D-Ala2-Met5-enkephalinamide (DAME), caused a fall in blood pressure (BP) following right atrial administration (RA) in urethane-anesthetized rats that were also atropinized, paralyzed, and artificially ventilated.	Radium	136-138	proenkephalin	Rattus norvegicus	3-13
6811526-5	1982	l-1) was less in RA than C from 1.0 +/- 0.15 (SE) (C = 1.1 +/- 0.17) at rest to 5.3 +/- 1.25 (C = 6.8 +/- 0.98) at 60% VO2 max (P less than 0.10).	Radium	17-19	aldo-keto reductase family 1 member C4	Homo sapiens	51-58
7034195-4	1981	Although the presence of RA in the CSF was confirmed in this study, no direct correlation seems to exist between it values and the elevated blood pressure; therefore, the pathophysiological significance of the renin-angiotensin system in the CSF and its relation to centrally generated hypertension remains questionable.	Radium	25-27	colony stimulating factor 2	Homo sapiens	35-38
7001194-2	1980	This increase in Ra raises CSF pressure (CSFP), which rise provokes a redistribution of arteriovenous pressures across the cerebrovascular bed.	Radium	17-19	colony stimulating factor 2	Homo sapiens	27-30
69627-4	1977	The reverse transcriptase - p30 complex stimulated [3H]TMP incorporation into (dT)12 - (rA)n 2- to 3-fold compared to that observed with the purified enzyme alone.	Radium	88-90	centromere protein V	Homo sapiens	28-31
7379531-10	1980	Our results indicate that in clamped kidneys an increase of RA causes a reduction of PGC and hence a reduction of pressure at the baroreceptor site which may act as a trigger mechanism for renin release.	Radium	60-62	progastricsin	Rattus norvegicus	85-88
426056-4	1979	This is in contrast to the rise in Ra seen after insulin withdrawal in depancreatized dogs, which have normal levels of IRG.	Radium	35-37	insulin	Canis lupus familiaris	49-56
426056-6	1979	When near basal IRG levels were provided during ST infusion in normal dogs, Ra increased, indicating that glucagon contributes to the acute development of diabetes.	Radium	76-78	somatostatin	Canis lupus familiaris	48-50
1265008-7	1976	The patient with active RA with a low serum albumin would be unusually susceptible to changes induced by combinations of strongly bound anti-inflammatory drugs.	Radium	24-26	albumin	Homo sapiens	44-51
195659-5	1977	Steady exposure to acetylcholine abolished both forms of RA.5 Two competitive inhibitors of cholinesterase, neostigmine and ambenonium, were also shown to evoke RA in nerve and muscle.	Radium	57-59	butyrylcholinesterase	Rattus norvegicus	92-106
195659-5	1977	Steady exposure to acetylcholine abolished both forms of RA.5 Two competitive inhibitors of cholinesterase, neostigmine and ambenonium, were also shown to evoke RA in nerve and muscle.	Radium	161-163	butyrylcholinesterase	Rattus norvegicus	92-106
195659-6	1977	The generation times for nerve RA and muscle RA were similar to those following ecothiopate.6 It was concluded that nerve RA and muscle RA were generated after the inhibition of cholinesterase by ecothiopate as a result of the prolonged action of acetylcholine upon cholinoceptive sites on the nerve terminal and motor endplate respectively.	Radium	31-33	butyrylcholinesterase	Rattus norvegicus	178-192
862128-6	1977	(3) The activity of constitutive aryl hydrocarbon hydroxylase (AHH) was slightly decreased after exposure to RA but the level of enzyme induced by benz[a]anthracene was strongly reduced to 20% of the controls.	Radium	109-111	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-61
862128-6	1977	(3) The activity of constitutive aryl hydrocarbon hydroxylase (AHH) was slightly decreased after exposure to RA but the level of enzyme induced by benz[a]anthracene was strongly reduced to 20% of the controls.	Radium	109-111	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	63-66
63195-11	1976	In such cases Ra-titers mostly occurred either together with Rb2-titers alone or concomitantly with both Rb2- and Rc-titers.	Radium	14-16	RB transcriptional corepressor like 2	Homo sapiens	105-108
33667931-2	2021	The highest activity concentrations found were (606.2 +- 25.13), (8.07 +- 6.37), (10.01 +- 1.45), (43.97 +- 5.54) Bq.kg-1 for K-40, Ra-226, Ra-228 and Th-228, respectively.	Radium	132-134	keratin 40	Homo sapiens	126-130
1206671-4	1975	(3) beta-glucuronidase and beta-N-acetylglucosaminidase levels in the SF of RA correlated well with each other but not with hyaluronidase.	Radium	76-78	glucuronidase beta	Homo sapiens	4-22
1206671-4	1975	(3) beta-glucuronidase and beta-N-acetylglucosaminidase levels in the SF of RA correlated well with each other but not with hyaluronidase.	Radium	76-78	O-GlcNAcase	Homo sapiens	27-55
1206671-5	1975	(4) beta-glucuronidase and beta-N-acetylglucosaminidase levels were higher in the SF of RA than in the corresponding serum, while the converse was true for hyaluronidase.	Radium	88-90	glucuronidase beta	Homo sapiens	4-22
1206671-5	1975	(4) beta-glucuronidase and beta-N-acetylglucosaminidase levels were higher in the SF of RA than in the corresponding serum, while the converse was true for hyaluronidase.	Radium	88-90	O-GlcNAcase	Homo sapiens	27-55
4364334-7	1974	During contact of neutrophils with RA serum-treated zymosan particles epinephrine, isoproterenol, and cyclic AMP inhibited both particle ingestion and beta-glucuronidase discharge.	Radium	35-37	glucuronidase beta	Homo sapiens	151-169
33880925-4	2021	For gas-sensing ability, the ASGA exhibits an excellent response of Ra/Rg = 137.4 to 20 ppm of ethanol at the optimum temperature of 210  C and can reach a response of 1.2 even at the limit detection concentration of 0.25 ppm.	Radium	68-70	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	4-7
33381897-9	2021	Therefore, they could be separated from other antibody-defined RA subsets previously associated with the HLA-B*08 allele.	Radium	63-65	major histocompatibility complex, class I, B	Homo sapiens	105-110
33381897-12	2021	CONCLUSION: Our results identify HLA-B*08 carrying Asp-9 as the most associated MHC locus with anti-CarP+ /anti-CCP- RA.	Radium	117-119	major histocompatibility complex, class I, B	Homo sapiens	33-38
33381897-12	2021	CONCLUSION: Our results identify HLA-B*08 carrying Asp-9 as the most associated MHC locus with anti-CarP+ /anti-CCP- RA.	Radium	117-119	major histocompatibility complex, class I, C	Homo sapiens	80-83
33381897-13	2021	This knowledge contributes to clarify the role of the HLA in susceptibility to RA subsets by shaping the spectrum of RA autoantibodies.	Radium	79-81	major histocompatibility complex, class II, DR beta 1	Homo sapiens	54-57
33381897-13	2021	This knowledge contributes to clarify the role of the HLA in susceptibility to RA subsets by shaping the spectrum of RA autoantibodies.	Radium	117-119	major histocompatibility complex, class II, DR beta 1	Homo sapiens	54-57
33982895-12	2021	CONCLUSION: IL-34 is a novel endogenous factor that remodels hypermetabolic M34 MPhis and facilitates their cross-regulation with effector T cells to advance RA inflammatory bone destruction.	Radium	158-160	interleukin 34	Mus musculus	12-17
33565209-0	2021	Switching to iGlarLixi vs Continuation of Daily or Weekly GLP-1 RA in Insufficiently Controlled Type 2 Diabetes: A LixiLan-G Trial Subgroup Analysis by HbA1c and GLP-1 RA Use at Screening.	Radium	64-66	glucagon like peptide 1 receptor	Homo sapiens	58-63
33640375-8	2021	Inhibition of activated microglia with minocycline or the blockade of cytokines (TNF-alpha and IL-1beta) with a receptor antagonist (RA) attenuated neuronal apoptosis after exposure to ketamine.	Radium	133-135	tumor necrosis factor	Rattus norvegicus	81-90
33640375-8	2021	Inhibition of activated microglia with minocycline or the blockade of cytokines (TNF-alpha and IL-1beta) with a receptor antagonist (RA) attenuated neuronal apoptosis after exposure to ketamine.	Radium	133-135	interleukin 1 alpha	Rattus norvegicus	95-103
33400403-4	2021	MATERIALS AND METHODS: Prospective cohort study of men starting GLP-1 RA therapy for type 2 diabetes mellitus.	Radium	70-72	glucagon like peptide 1 receptor	Homo sapiens	64-69
33400403-9	2021	CONCLUSION: GLP-1 RA therapy improves weight and HbA1c without adverse effects on testosterone.	Radium	18-20	glucagon like peptide 1 receptor	Homo sapiens	12-17
33550047-2	2021	The underlying mechanism and its effect on CD68 macrophages were investigated, as a further argument to its possible efficacy in RA treatment.	Radium	129-131	Cd68 molecule	Rattus norvegicus	43-47
33902658-9	2021	Our results suggest that the inhibition of RARalphaS77 phosphorylation by either expressing RARalphaS77A or inhibiting RARalpha"s phosphokinase CDK7, can bypass RA stimuli to transactivate tumor-suppressive miR-3074-5p and reduce oncogenic DHRS3, thus overcoming the RA-resistance of TNBC.	Radium	43-45	cyclin dependent kinase 7	Homo sapiens	144-148
33864629-0	2021	Treatment Patterns and Persistence With GLP-1 RA Treatments Among Patients With Type 2 Diabetes in France: A Retrospective Cohort Analysis.	Radium	46-48	glucagon like peptide 1 receptor	Homo sapiens	40-45
33864629-3	2021	METHODS: This retrospective cohort analysis presents longitudinal data from approximately 7500 French retail pharmacies that filled GLP-1-RA prescriptions for GLP-1 RA-naive patients with T2D ("index therapy": dulaglutide; once-weekly exenatide [exenatide QW]; twice-daily exenatide [exenatide BID]; liraglutide) between January 2015 and December 2016 (follow-up >= 12 months).	Radium	138-140	glucagon like peptide 1 receptor	Homo sapiens	132-137
33864629-3	2021	METHODS: This retrospective cohort analysis presents longitudinal data from approximately 7500 French retail pharmacies that filled GLP-1-RA prescriptions for GLP-1 RA-naive patients with T2D ("index therapy": dulaglutide; once-weekly exenatide [exenatide QW]; twice-daily exenatide [exenatide BID]; liraglutide) between January 2015 and December 2016 (follow-up >= 12 months).	Radium	165-167	glucagon like peptide 1 receptor	Homo sapiens	159-164
33213987-6	2021	There were indications that TPO-RA treatment enhanced platelet function, with respect to platelet-monocyte aggregates, soluble P-selectin, GPVI expression, and adhesion under flow.	Radium	32-34	thyroid peroxidase	Homo sapiens	28-31
33213987-6	2021	There were indications that TPO-RA treatment enhanced platelet function, with respect to platelet-monocyte aggregates, soluble P-selectin, GPVI expression, and adhesion under flow.	Radium	32-34	selectin P	Homo sapiens	127-137
33213987-6	2021	There were indications that TPO-RA treatment enhanced platelet function, with respect to platelet-monocyte aggregates, soluble P-selectin, GPVI expression, and adhesion under flow.	Radium	32-34	glycoprotein VI platelet	Homo sapiens	139-143
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	interleukin 6	Homo sapiens	45-48
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	tumor necrosis factor	Homo sapiens	50-53
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	interleukin 1 beta	Homo sapiens	55-60
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	mitogen-activated protein kinase 1	Homo sapiens	65-70
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	tumor necrosis factor	Homo sapiens	82-85
33902658-9	2021	Our results suggest that the inhibition of RARalphaS77 phosphorylation by either expressing RARalphaS77A or inhibiting RARalpha"s phosphokinase CDK7, can bypass RA stimuli to transactivate tumor-suppressive miR-3074-5p and reduce oncogenic DHRS3, thus overcoming the RA-resistance of TNBC.	Radium	43-45	dehydrogenase/reductase 3	Homo sapiens	240-245
33902658-9	2021	Our results suggest that the inhibition of RARalphaS77 phosphorylation by either expressing RARalphaS77A or inhibiting RARalpha"s phosphokinase CDK7, can bypass RA stimuli to transactivate tumor-suppressive miR-3074-5p and reduce oncogenic DHRS3, thus overcoming the RA-resistance of TNBC.	Radium	92-94	retinoic acid receptor, alpha	Mus musculus	43-51
33685123-5	2021	The transcript abundance of cyp26a1 was inhibited and subsequent increasing embryonic all-trans RA level was observed in embryos, showing RAR/RXR antagonistic activity.	Radium	96-98	cytochrome P450, family 26, subfamily A, polypeptide 1	Oryzias latipes	28-35
33835520-1	2021	AIM: Previous studies have reported an elevation in adiponectin concentrations using glucagon-like peptide-1 receptor agonists (GLP-1 RA) therapy; however, this possible pleiotropic effect is still uncertain.	Radium	134-136	adiponectin, C1Q and collagen domain containing	Homo sapiens	52-63
33853479-5	2021	Furthermore, higher proportion of Tfh cells defined by all definitions and a specified definition (CD4+CXCR5+PD-1high) was observed when S+RA compared to S-RA patients.Expert opinion:The results demonstrate that circulating Tfh are highly elevated in RA patients highlights its potential use as a biomarker and a target for RA therapy.	Radium	139-141	CD4 molecule	Homo sapiens	99-102
33853479-5	2021	Furthermore, higher proportion of Tfh cells defined by all definitions and a specified definition (CD4+CXCR5+PD-1high) was observed when S+RA compared to S-RA patients.Expert opinion:The results demonstrate that circulating Tfh are highly elevated in RA patients highlights its potential use as a biomarker and a target for RA therapy.	Radium	139-141	C-X-C motif chemokine receptor 5	Homo sapiens	103-108
33863738-2	2021	Angiotensin II (AngII), the main effector of the renin-angiotensin (RA) system, elicits fibrosis in both kidney and lung.	Radium	68-70	angiotensinogen	Homo sapiens	0-14
33863738-2	2021	Angiotensin II (AngII), the main effector of the renin-angiotensin (RA) system, elicits fibrosis in both kidney and lung.	Radium	68-70	angiotensinogen	Homo sapiens	16-21
33835520-1	2021	AIM: Previous studies have reported an elevation in adiponectin concentrations using glucagon-like peptide-1 receptor agonists (GLP-1 RA) therapy; however, this possible pleiotropic effect is still uncertain.	Radium	134-136	glucagon like peptide 1 receptor	Homo sapiens	85-117
33835520-6	2021	RESULTS: A meta-analysis of 20 randomized controlled trials involving 1,497 individuals demonstrated a significant increase in adiponectin levels after GLP-1 RA administration (WMD: 0.59 mug/mL, 95% CI: 0.10, 1.08, p = 0.02).	Radium	158-160	adiponectin, C1Q and collagen domain containing	Homo sapiens	127-138
33835520-6	2021	RESULTS: A meta-analysis of 20 randomized controlled trials involving 1,497 individuals demonstrated a significant increase in adiponectin levels after GLP-1 RA administration (WMD: 0.59 mug/mL, 95% CI: 0.10, 1.08, p = 0.02).	Radium	158-160	glucagon like peptide 1 receptor	Homo sapiens	152-157
33835520-8	2021	CONCLUSIONS: GLP-1 RA treatment is associated with an increase in adiponectin levels.	Radium	19-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
33730072-9	2021	These results suggest that 13-cis RA and 1,25-VD3 significantly suppress TNF-alpha mediated cell invasion and therefore potentially act as preventive agents against PDAC.	Radium	34-36	tumor necrosis factor	Homo sapiens	73-82
33889575-6	2021	Overall, our findings demonstrate that IL-17 collaborating with IFNgamma to induce TA-MSC transformation, which can be targeted by RA for melanoma treatment.	Radium	131-133	interleukin 17A	Mus musculus	39-44
33889575-6	2021	Overall, our findings demonstrate that IL-17 collaborating with IFNgamma to induce TA-MSC transformation, which can be targeted by RA for melanoma treatment.	Radium	131-133	interferon gamma	Mus musculus	64-72
33789275-3	2021	PATIENTS/METHODS: UK hematologists completed a survey to characterize self-reported practice patterns related to TPO-RA tapering and discontinuation in patients with ITP.	Radium	117-119	thyroid peroxidase	Homo sapiens	113-116
33789275-9	2021	Individual differences need to be taken into account when considering TPO-RA tapering or discontinuation.	Radium	74-76	thyroid peroxidase	Homo sapiens	70-73
33789275-10	2021	CONCLUSIONS: Tapering and discontinuation of TPO-RA therapy may be considered for certain patients with ITP.	Radium	49-51	thyroid peroxidase	Homo sapiens	45-48
33854754-5	2021	We compared the incidence of inpatient, emergency room, or outpatient diagnosis of GUI (bacterial and mycotic) within 6 months of SGLT2i or GLP1-RA initiation.	Radium	145-147	glucagon like peptide 1 receptor	Homo sapiens	140-144
33854754-8	2021	Results: One hundred and thirty-three patients were initiated on SGLT2i therapy and 341 patients newly initiated on GLP1-RA therapy.	Radium	121-123	glucagon like peptide 1 receptor	Homo sapiens	116-120
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	tumor necrosis factor	Homo sapiens	53-62
32662411-9	2021	CONCLUSIONS: Iguratimod ameliorates RA progression via regulating miR-146a mediated IRAK1 expression and TRAF6/JNK1 pathway.	Radium	36-38	microRNA 146a	Rattus norvegicus	66-74
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	matrix metallopeptidase 9	Homo sapiens	86-112
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	matrix metallopeptidase 9	Homo sapiens	114-119
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	mitogen-activated protein kinase 8	Homo sapiens	146-169
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	mitogen-activated protein kinase 8	Homo sapiens	171-174
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	nuclear factor kappa B subunit 1	Homo sapiens	180-202
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	nuclear factor kappa B subunit 1	Homo sapiens	204-213
33730072-8	2021	Moreover, treatment of SP600125 (a specific inhibitor of JNK pathway) or cotreatment of 13-cis RA and 1,25-VD3 significantly induced a decreased expression of miR-221 and an increased expression of TIMP-3 protein.	Radium	95-97	mitogen-activated protein kinase 8	Homo sapiens	57-60
33730072-8	2021	Moreover, treatment of SP600125 (a specific inhibitor of JNK pathway) or cotreatment of 13-cis RA and 1,25-VD3 significantly induced a decreased expression of miR-221 and an increased expression of TIMP-3 protein.	Radium	95-97	microRNA 221	Homo sapiens	159-166
33730072-8	2021	Moreover, treatment of SP600125 (a specific inhibitor of JNK pathway) or cotreatment of 13-cis RA and 1,25-VD3 significantly induced a decreased expression of miR-221 and an increased expression of TIMP-3 protein.	Radium	95-97	TIMP metallopeptidase inhibitor 3	Homo sapiens	198-204
32662411-9	2021	CONCLUSIONS: Iguratimod ameliorates RA progression via regulating miR-146a mediated IRAK1 expression and TRAF6/JNK1 pathway.	Radium	36-38	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	84-89
33563064-1	2021	RASAL2 (RAS protein activator like 2), a RASGTPase activating protein, can catalyze the hydrolysis of RAS-GTP into RAS-GDP to inactivate the RAS pathway in various types of cancer cells.	Radium	102-106	RAS protein activator like 2	Homo sapiens	0-6
33563064-1	2021	RASAL2 (RAS protein activator like 2), a RASGTPase activating protein, can catalyze the hydrolysis of RAS-GTP into RAS-GDP to inactivate the RAS pathway in various types of cancer cells.	Radium	102-106	RAS protein activator like 2	Homo sapiens	8-36
32281449-8	2021	Treatment failure was observed in 21% TPO-RA-treated patients and 47% control arm patients (RR = 0.42, 95% CI 0.33-0.53) in RCTs during a median follow-up of 13 weeks, and in 29% TPO-RA-treated patients in cohort studies, during a median follow-up of 69 weeks.	Radium	42-44	thyroid peroxidase	Homo sapiens	38-41
32281449-10	2021	RR of WHO grade >=2 bleeding was 0.58 (0.38-0.86) in TPO-RA-treated patients, compared to control arm patients.	Radium	57-59	thyroid peroxidase	Homo sapiens	53-56
33583939-10	2021	TYK2 rs280500, rs280521, and rs8108236 were associated with RA susceptibility in the dominant model, but the same was not observed for rs280519 and rs12720253 (P<0.05).	Radium	60-62	tyrosine kinase 2	Homo sapiens	0-4
33583939-11	2021	Furthermore, 3 risk haplotypes (AAAGT, AGGAT, and GAAAT) and a protective haplotype (GAGGT) of TYK2 gene were associated with RA susceptibility (P<0.05).	Radium	126-128	tyrosine kinase 2	Homo sapiens	95-99
33512051-6	2022	The effects of RA-VEGF scaffolds on HUVECs angiogenesis were investigated in vitro.	Radium	15-17	vascular endothelial growth factor A	Homo sapiens	18-22
33017635-10	2021	Treatment of RA-XII inhibited the formation of autophagosomes, which is implied by the GFP-LC3 fluorescent dots, MDC-stained autophagic vesicles and LC3 protein expression.	Radium	13-15	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	91-94
33017635-10	2021	Treatment of RA-XII inhibited the formation of autophagosomes, which is implied by the GFP-LC3 fluorescent dots, MDC-stained autophagic vesicles and LC3 protein expression.	Radium	13-15	C-C motif chemokine ligand 22	Homo sapiens	113-116
33017635-10	2021	Treatment of RA-XII inhibited the formation of autophagosomes, which is implied by the GFP-LC3 fluorescent dots, MDC-stained autophagic vesicles and LC3 protein expression.	Radium	13-15	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	149-152
33555084-9	2021	NK1 RAs were used in 45%/42%/19% of patients receiving cisplatin-/AC-/carboplatin-based chemotherapy, respectively; 18%/24%/7% received the guideline-recommended NK1 RA-5-HT3 RA-dexamethasone combination; no antiemetics were prescribed for 12% of the treatments.	Radium	4-6	tachykinin receptor 1	Homo sapiens	0-3
33581878-13	2021	GLP1-RA use also increased, but observed usage remained lower than SGLT2 inhibitors.	Radium	5-7	glucagon like peptide 1 receptor	Homo sapiens	0-4
33362086-9	2021	By using the optimized model, the turning experiment of BaF2 HDOEs was completed, and then the BaF2 HDOEs with Ra=2.75nm were obtained.	Radium	111-113	BANF family member 2	Homo sapiens	56-60
33245530-0	2021	Preference for Oral and Injectable GLP-1 RA Therapy Profiles in Japanese Patients with Type 2 Diabetes: A Discrete Choice Experiment.	Radium	41-43	glucagon	Homo sapiens	35-40
33245530-14	2021	CONCLUSION: Japanese patients with T2D appear to prefer oral GLP-1 RA profiles over injectable GLP-1 RA profiles, and administration appears to be the most important factor in this decision.	Radium	67-69	glucagon	Homo sapiens	61-66
32748760-6	2021	Moreover, the western blot results further indicated that the inhibitory effect of RA might be due to its suppressive role in let-7f-5p-targeted AMER3 and SLC9A9 regulation.	Radium	83-85	APC membrane recruitment protein 3	Homo sapiens	145-150
33362086-9	2021	By using the optimized model, the turning experiment of BaF2 HDOEs was completed, and then the BaF2 HDOEs with Ra=2.75nm were obtained.	Radium	111-113	BANF family member 2	Homo sapiens	95-99
32748760-6	2021	Moreover, the western blot results further indicated that the inhibitory effect of RA might be due to its suppressive role in let-7f-5p-targeted AMER3 and SLC9A9 regulation.	Radium	83-85	solute carrier family 9 member A9	Homo sapiens	155-161
33882773-8	2021	In vivo evaluation revealed that IRE with single-dose administration of Ra-233, compared to IRE alone, reduced the rate of tumor recurrence by 40% following initial apparent complete ablation and decreased the rate of proliferation of incompletely ablated tumor as quantified in Ki-67 staining (53.58 +- 16.0% for IRE vs. 20.12 +- 1.63%; for IRE plus Ra-223; p = 0.004).	Radium	72-74	antigen identified by monoclonal antibody Ki 67	Mus musculus	279-284
33300091-4	2021	RESULTS: The analysis included 932 eligible patients with T2DM who had their first GLP-1 RA prescription (index date) between September 2016 and July 2018.	Radium	89-91	glucagon like peptide 1 receptor	Homo sapiens	83-88
33977469-4	2021	But also the rate of nucleotide exchange, i.e., the Ras-GDP/GTP cycling rate, can have a major impact on Ras function, as illustrated perhaps most impressively by newly discovered fast-cycling oncogenic mutants of the Ras-related GTPase Rac1.	Radium	52-55	Rac family small GTPase 1	Homo sapiens	237-241
32712041-5	2021	However physician have to keep in mind that thromboembolism rates appear to be higher with TPO-RA treatment in ITP patients at high risk of thrombosis, and that data from "real-life" studies with very long term follow up are not available.	Radium	95-97	thyroid peroxidase	Homo sapiens	91-94
33410302-11	2020	CONCLUSION: Our data suggest that the association between FasL rs763110 polymorphism and RA susceptibility in Western Eurasians observed in previous studies might be overestimated and should be limited to the population of Southwestern Asia until further investigations are performed.	Radium	89-91	Fas ligand	Homo sapiens	58-62
33156626-6	2020	The tailored polymer could self-assemble into nanoscale micelles to encapsulate RAS-selective lethal small molecule 3, a covalent GPX4 inhibitor.	Radium	80-83	glutathione peroxidase 4	Mus musculus	130-134
33333629-9	2021	PTLD rate (Alemtuzumab 0.8% vs. r-ATG 2.2% vs. IL2-RA 1%; P: .028) was significantly higher in the anti-thymocyte group.	Radium	51-53	interleukin 2	Homo sapiens	47-50
33292155-7	2021	LEADER, REWIND and SUSTAIN-6 trials have demonstrated reduction in rates of major adverse cardiovascular events with active GLP-1 RA treatment but ELIXA, PIONEER 6 and EXSCEL have been neutral.	Radium	130-132	glucagon like peptide 1 receptor	Homo sapiens	124-129
33090723-4	2020	Thus, the purpose of this study was to investigate the molecular mechanism through which AFP promotes tumour cell proliferation by interfering with the RA-RAR signal pathway.	Radium	152-154	alpha fetoprotein	Homo sapiens	89-92
33090723-4	2020	Thus, the purpose of this study was to investigate the molecular mechanism through which AFP promotes tumour cell proliferation by interfering with the RA-RAR signal pathway.	Radium	152-154	retinoic acid receptor alpha	Homo sapiens	155-158
33447242-1	2020	Inhibition of Ras farnesylation in acute has been found to upregulate the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) activity.	Radium	14-17	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	115-126
32814348-5	2020	Median time of Tpo-RA exposure during pregnancy was 4.4 weeks [range: 1-39 weeks]; the indication for starting Tpo-RA was preparation for delivery in 10/17 (58%) pregnancies whereas 4 had chronic refractory symptomatic ITP and 3 were on eltrombopag when the pregnancy started.	Radium	19-21	thyroid peroxidase	Homo sapiens	15-18
32814348-5	2020	Median time of Tpo-RA exposure during pregnancy was 4.4 weeks [range: 1-39 weeks]; the indication for starting Tpo-RA was preparation for delivery in 10/17 (58%) pregnancies whereas 4 had chronic refractory symptomatic ITP and 3 were on eltrombopag when the pregnancy started.	Radium	115-117	thyroid peroxidase	Homo sapiens	111-114
33314638-7	2021	RESULTS: Rejection rates at 6 months (alemtuzumab 8.6% vs r-ATG 7.8% vs IL2-RA 9.2%; P = .30) and 12 months (alemtuzumab 17.2% vs r-ATG 15.7% vs IL2-RA 16.5%; P = .70) were not significantly different between induction groups.	Radium	76-78	interleukin 2	Homo sapiens	72-75
32604577-6	2020	The SnO2 thin-film sensor, which was created by ion sputtering for 10 min, shows an excellent sensor response (Ra/Rg where Ra is the electric resistance under air and Rg is the electric resistance under the test gas) for detecting 1 ppm H2S at 350 C.	Radium	111-113	gastrin	Homo sapiens	212-215
32620467-5	2020	OBJECTIVE: The factors that can lead to RA includes inflammatory cascades, increased levels of (TNF-alpha) tumor necrosis factor alpha, IL-1b and IL-17 (interleukins) along with reduced levels of Nrf2 factors (nuclear factor-erythroid 2-related factor-2).	Radium	40-42	interleukin 1 beta	Homo sapiens	136-141
32620467-5	2020	OBJECTIVE: The factors that can lead to RA includes inflammatory cascades, increased levels of (TNF-alpha) tumor necrosis factor alpha, IL-1b and IL-17 (interleukins) along with reduced levels of Nrf2 factors (nuclear factor-erythroid 2-related factor-2).	Radium	40-42	interleukin 17A	Homo sapiens	146-151
32620467-5	2020	OBJECTIVE: The factors that can lead to RA includes inflammatory cascades, increased levels of (TNF-alpha) tumor necrosis factor alpha, IL-1b and IL-17 (interleukins) along with reduced levels of Nrf2 factors (nuclear factor-erythroid 2-related factor-2).	Radium	40-42	NFE2 like bZIP transcription factor 2	Homo sapiens	196-200
32620467-5	2020	OBJECTIVE: The factors that can lead to RA includes inflammatory cascades, increased levels of (TNF-alpha) tumor necrosis factor alpha, IL-1b and IL-17 (interleukins) along with reduced levels of Nrf2 factors (nuclear factor-erythroid 2-related factor-2).	Radium	40-42	NFE2 like bZIP transcription factor 2	Homo sapiens	210-253
33153459-7	2020	We also report additional data that further suggests only WT RAS-GTP levels are reduced with EGFR inhibition and that KRAS G13D is impaired in binding to NF1.	Radium	61-64	epidermal growth factor receptor	Homo sapiens	93-97
32777740-0	2020	Radiological evaluation of Ra-226, Ra-228 and K-40 in tea samples: A comparative study of effective dose and cancer risk.	Radium	0-2	keratin 40	Homo sapiens	46-50
32888091-7	2020	RESULTS: The RA improved significantly in 500-7500 lx in both groups (NCS, p = 0.001; CS, p = 0.046).	Radium	13-15	citrate synthase	Homo sapiens	71-73
32535203-4	2020	Molecular docking suggested a strong binding of RA to the functionally important residues of MARK.	Radium	48-50	microtubule affinity regulating kinase 1	Homo sapiens	93-97
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	27-29	AKT serine/threonine kinase 1	Rattus norvegicus	80-84
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	27-29	mechanistic target of rapamycin kinase	Rattus norvegicus	86-90
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	27-29	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	96-99
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	AKT serine/threonine kinase 1	Rattus norvegicus	80-84
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	mechanistic target of rapamycin kinase	Rattus norvegicus	86-90
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	96-99
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	AKT serine/threonine kinase 1	Rattus norvegicus	170-174
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	mechanistic target of rapamycin kinase	Rattus norvegicus	176-180
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	186-189
33132650-19	2020	Compared with those in the RA + CD group, the mRNA expression levels of PI3KC1, Akt1, mTOR, and p62 in the RA + HM group were significantly higher (P PI3KC1 < 0.01 and P Akt1, mTOR, and p62 < 0.05), while those of LC3B were significantly lower (P < 0.05).	Radium	107-109	microtubule associated protein 1 light chain 3 beta	Homo sapiens	214-218
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	AKT serine/threonine kinase 1	Rattus norvegicus	92-96
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	mechanistic target of rapamycin kinase	Rattus norvegicus	104-108
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	AKT serine/threonine kinase 1	Rattus norvegicus	146-150
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	mechanistic target of rapamycin kinase	Rattus norvegicus	167-171
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	190-193
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	microtubule associated protein 1 light chain 3 beta	Homo sapiens	245-249
33132650-20	2020	Compared with the RA + CD group, the RA + HM group exhibited significantly higher PI3KC1, p-Akt1, and p-mTOR protein levels (P PI3KC1 < 0.01, P p-Akt1 < 0.05, and P p-mTOR < 0.01), a higher p62 protein level (P = 0.057), and significantly lower LC3B and Vps34 protein levels (P < 0.01 for both) in colon tissue.	Radium	37-39	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	254-259
32910778-6	2020	LIMITATIONS: There were relatively small numbers of available publications, some heterogeneity regarding protocols, and differences in the GLP-1 RA compound used.	Radium	145-147	glucagon like peptide 1 receptor	Homo sapiens	139-144
33101545-2	2020	B cells are important components of rheumatoid arthritis- (RA-) mediated immune response; hence, CNV in the regulators of B cells (such as VPREB1) can influence RA susceptibility.	Radium	59-61	V-set pre-B cell surrogate light chain 1	Homo sapiens	139-145
33101545-3	2020	In this study, we aimed to explore the association of CNV in the VPREB1 gene with RA susceptibility in the Pakistani population.	Radium	82-84	V-set pre-B cell surrogate light chain 1	Homo sapiens	65-71
33042280-9	2020	Results: In animals bearing EGFR(+) tumors, a significant difference in RA values between treated and untreated animals was observed (RA = 0.24 +- 0.15 and 0.61 +- 0.18, respectively, p=0.027), with an area under the curve - receiver operating characteristic (AUC-ROC) value of 0.92.	Radium	72-74	epidermal growth factor receptor	Mus musculus	28-32
32692720-9	2020	This suggests the Mst1-AMPK-Sirt1 axis is a potential target for RA therapy.	Radium	65-67	macrophage stimulating 1	Homo sapiens	18-22
32359071-5	2020	The relationships between the changes in RA functions and in brain natriuretic peptide (BNP) were evaluated in both the dilated and non-dilated RA groups.	Radium	41-43	natriuretic peptide B	Homo sapiens	61-86
32359071-5	2020	The relationships between the changes in RA functions and in brain natriuretic peptide (BNP) were evaluated in both the dilated and non-dilated RA groups.	Radium	41-43	natriuretic peptide B	Homo sapiens	88-91
32359071-7	2020	The changes in RA peak LS and in RA early LSR were significantly correlated with the changes in BNP (DeltaRA-LS: r = -0.63, DeltaRA-early LSR: r = 0.65) and pulmonary vascular resistance (PVR) (DeltaRA-LS: r = -0.69, DeltaRA-early LSR: r = 0.66) in the nondilated RA group.	Radium	15-17	natriuretic peptide B	Homo sapiens	96-99
32359071-7	2020	The changes in RA peak LS and in RA early LSR were significantly correlated with the changes in BNP (DeltaRA-LS: r = -0.63, DeltaRA-early LSR: r = 0.65) and pulmonary vascular resistance (PVR) (DeltaRA-LS: r = -0.69, DeltaRA-early LSR: r = 0.66) in the nondilated RA group.	Radium	33-35	natriuretic peptide B	Homo sapiens	96-99
32359071-10	2020	The improvements in RA reservoir and conduit functions were significantly correlated with the changes in BNP levels and PVR in CTEPH patients with normal RA sizes.	Radium	20-22	natriuretic peptide B	Homo sapiens	105-108
32866246-14	2021	MCT significantly increased RA-content of type-1 (proinflammatory) CD68-positive M1-macrophages without affecting type-2 (anti-inflammatory) M2-macrophages.	Radium	28-30	Cd68 molecule	Rattus norvegicus	67-71
32476083-10	2020	Patients who achieved R within 14 days from the start of TPO-RA administration exhibited a higher 2-year TFR rate, compared with patients who did not (87.5% vs. 48.5%, p = 0.0106).	Radium	61-63	thyroid peroxidase	Homo sapiens	57-60
32692720-9	2020	This suggests the Mst1-AMPK-Sirt1 axis is a potential target for RA therapy.	Radium	65-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	23-27
32692720-9	2020	This suggests the Mst1-AMPK-Sirt1 axis is a potential target for RA therapy.	Radium	65-67	sirtuin 1	Homo sapiens	28-33
32130282-5	2020	RESULTS: TNFR1 and leptin were higher in the T2DM group with RA than in the T2DM group without RA and control group.	Radium	61-63	TNF receptor superfamily member 1A	Homo sapiens	9-14
32679012-6	2022	RA-96 Fab fragment was conjugated to the liposomal surface of the nanoparticle to increase tumor homing ability.	Radium	0-2	FA complementation group B	Homo sapiens	6-9
32305361-9	2020	The level of phosphorylated Cx43 at Ser386 (p-Cx43Ser368), but not total Cx43, was higher in LA versus RA myocytes.	Radium	103-105	gap junction protein alpha 1	Homo sapiens	28-32
32509155-4	2020	Based on these previous findings that circadian timekeeping is disturbed in RA at molecular level, the aim of this study was to observe the influence of moxibustion on expression level and circadian rhythm of REV-ERBalpha at different tissues of RA rats.	Radium	76-78	nuclear receptor subfamily 1, group D, member 1	Rattus norvegicus	209-221
32001795-9	2020	In the epididymal white adipose tissue (eWAT), TL1A deficiency in HF-diet-fed mice resulted in a reduced abundance of IL-18Ra+ type-1 ILCs and gammadeltaT cells as well as markedly reduced expression of the mitochondria-regulating genes Ucp1, Ucp2, Ucp3, and Prdm16.	Radium	121-125	tumor necrosis factor (ligand) superfamily, member 15	Mus musculus	47-51
32120069-7	2020	We show that alpha-Syn binds RA and translocates to the nucleus to selectively enhance gene transcription.	Radium	29-31	synuclein alpha	Homo sapiens	13-22
32120069-9	2020	Importantly, nuclear translocation of alpha-Syn following RA treatment enhances its toxicity in cultured neurons and the expression levels of PD-associated genes, including ATPase cation transporting 13A2 (ATP13A2) and PTEN-induced kinase1 (PINK1).	Radium	58-60	synuclein alpha	Homo sapiens	38-47
32120069-9	2020	Importantly, nuclear translocation of alpha-Syn following RA treatment enhances its toxicity in cultured neurons and the expression levels of PD-associated genes, including ATPase cation transporting 13A2 (ATP13A2) and PTEN-induced kinase1 (PINK1).	Radium	58-60	ATPase cation transporting 13A2	Homo sapiens	173-204
32120069-9	2020	Importantly, nuclear translocation of alpha-Syn following RA treatment enhances its toxicity in cultured neurons and the expression levels of PD-associated genes, including ATPase cation transporting 13A2 (ATP13A2) and PTEN-induced kinase1 (PINK1).	Radium	58-60	ATPase cation transporting 13A2	Homo sapiens	206-213
32120069-9	2020	Importantly, nuclear translocation of alpha-Syn following RA treatment enhances its toxicity in cultured neurons and the expression levels of PD-associated genes, including ATPase cation transporting 13A2 (ATP13A2) and PTEN-induced kinase1 (PINK1).	Radium	58-60	PTEN induced kinase 1	Homo sapiens	219-239
32120069-9	2020	Importantly, nuclear translocation of alpha-Syn following RA treatment enhances its toxicity in cultured neurons and the expression levels of PD-associated genes, including ATPase cation transporting 13A2 (ATP13A2) and PTEN-induced kinase1 (PINK1).	Radium	58-60	PTEN induced kinase 1	Homo sapiens	241-246
32315715-9	2020	Accordingly, gelatin zymography revealed lower Mmp2 activity in mutant samples upon RA-treatment (0.77-fold, 95% HDI: 0.60 - 0.96).	Radium	84-86	matrix metallopeptidase 2	Mus musculus	47-51
32617521-1	2020	The known collaboration between all-transretinoic acid and interferon motivates this study of the dependence of RA-induced leukemic cell differentiation on interferon regulatory factor-1 (IRF-1), a transcription factor that is the main mediator of interferon effects.	Radium	112-114	interferon regulatory factor 1	Homo sapiens	156-186
32617521-1	2020	The known collaboration between all-transretinoic acid and interferon motivates this study of the dependence of RA-induced leukemic cell differentiation on interferon regulatory factor-1 (IRF-1), a transcription factor that is the main mediator of interferon effects.	Radium	112-114	interferon regulatory factor 1	Homo sapiens	188-193
32617521-2	2020	In the HL-60 acute myeloid leukemia (AML) model that represents a rare RA-responsive subtype of AML, IRF-1 is not expressed until RA induces its prominent expression, and ectopic IRF-1 expression enhances RA-induced differentiation, motivating interest in how IRF-1 is putatively needed for RA response.	Radium	71-73	interferon regulatory factor 1	Homo sapiens	101-106
32617521-5	2020	However, elimination of IRF-1 inhibited RA-induced p47phox expression and inducible oxidative metabolism detected by reactive oxygen species (ROS), suggesting IRF-1 is essential for mature granulocytic inducible oxidative metabolism.	Radium	40-42	interferon regulatory factor 1	Homo sapiens	24-29
32617521-5	2020	However, elimination of IRF-1 inhibited RA-induced p47phox expression and inducible oxidative metabolism detected by reactive oxygen species (ROS), suggesting IRF-1 is essential for mature granulocytic inducible oxidative metabolism.	Radium	40-42	neutrophil cytosolic factor 1	Homo sapiens	51-58
32617521-5	2020	However, elimination of IRF-1 inhibited RA-induced p47phox expression and inducible oxidative metabolism detected by reactive oxygen species (ROS), suggesting IRF-1 is essential for mature granulocytic inducible oxidative metabolism.	Radium	40-42	interferon regulatory factor 1	Homo sapiens	159-164
32397319-6	2020	On the other hand, the Yxoss CBR  mesh from ReOss  was sandblasted, presenting an extremely rough surface with a Ra of 6.59 +- 0.76 microm.	Radium	113-115	carbonyl reductase 1	Homo sapiens	29-32
32523658-2	2020	Romiplostim is a peptide TPO-RA approved for over a decade to treat adults with ITP but was just recently US Food and Drug Administration approved to manage ITP in children 1 year of age and older who have had an inadequate response to corticosteroids, intravenous immunoglobulin, or splenectomy.	Radium	29-31	thyroid peroxidase	Homo sapiens	25-28
32130282-7	2020	Adiponectin were higher and IL-4 decreased in the T2DM group with RA compared to the control group.	Radium	66-68	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
32130282-7	2020	Adiponectin were higher and IL-4 decreased in the T2DM group with RA compared to the control group.	Radium	66-68	interleukin 4	Homo sapiens	28-32
32237479-12	2020	Based on MCDA model and clinical results, the benefit value, risk value and benefit-risk value of different doses, courses and combined administration of TGT in the treatment with RA were compared.	Radium	180-182	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	154-157
31770665-6	2020	CAD/CAM milling roughness simulation led to significantly (p &lt; 0.05) greater roughness (Ra and Rz), promoting a more irregular topography with scratches and grooves, and led to a lower fatigue performance for all the tested ceramics.	Radium	91-93	calmodulin 3	Homo sapiens	4-7
32149119-0	2020	A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene.	Radium	76-78	neurotrophic receptor tyrosine kinase 2	Homo sapiens	170-175
32149119-9	2020	A novel RA response DNA element in the NTRK2 gene was then identified by bioinformatics analysis and chromatin immunoprecipitation (ChIP) assay.	Radium	8-10	neurotrophic receptor tyrosine kinase 2	Homo sapiens	39-44
32149119-11	2020	Our study systematically provided the potential regulatory information of ATRA-triggered neuroblastoma differentiation, and in the NTRK2 gene, we identified a novel RA response DNA element, which may contribute to the differentiation in a human-specific manner.	Radium	76-78	neurotrophic receptor tyrosine kinase 2	Homo sapiens	131-136
31464042-5	2020	RESULTS: Pre-RA autoantibody levels were elevated in cases vs. controls as follows: ACPA-IgG 17.9 years, RF-IgA 14.2 years, RF-IgM 7.2 years, ACPA-IgA 6.2 years and ACPA-IgM and RF-IgA both at 5.0 years (p&lt;0.01, all comparisons).	Radium	13-15	proteinase 3	Homo sapiens	84-88
31164723-13	2020	The protective function of CRABP1 is likely attributed to its classically proposed (canonical) activity as a trap for RA, which will reduce RA availability, thereby dampening RA-stimulated ERK1/2 activation and adipocyte hypertrophy.	Radium	28-30	mitogen-activated protein kinase 3	Mus musculus	189-195
31164723-13	2020	The protective function of CRABP1 is likely attributed to its classically proposed (canonical) activity as a trap for RA, which will reduce RA availability, thereby dampening RA-stimulated ERK1/2 activation and adipocyte hypertrophy.	Radium	118-120	cellular retinoic acid binding protein I	Mus musculus	27-33
31164723-13	2020	The protective function of CRABP1 is likely attributed to its classically proposed (canonical) activity as a trap for RA, which will reduce RA availability, thereby dampening RA-stimulated ERK1/2 activation and adipocyte hypertrophy.	Radium	118-120	cellular retinoic acid binding protein I	Mus musculus	27-33
31527569-12	2019	After the inhibition of Pitx1, RARss2 expression was further increased by RA treatment in tendon cells.	Radium	31-33	paired like homeodomain 1	Homo sapiens	24-29
30885035-7	2020	Regression analysis revealed that pre-treatment levels of miR-199a-5p and miR-221-3p could help to predict platelet response to TPO-RA-treatment.	Radium	132-134	thyroid peroxidase	Homo sapiens	128-131
30963978-12	2020	CONCLUSION: The ongoing surge of interest in anticytokine therapy makes further study of visfatin highly relevant as it may serve as a base for innovational RA treatment.	Radium	157-159	nicotinamide phosphoribosyltransferase	Mus musculus	89-97
32359660-2	2020	The promoter responded linearly to a wide concentration range of at-RA in cells cotransfected with retinoic acid receptors (RAR).	Radium	68-70	retinoic acid receptor alpha	Homo sapiens	99-122
32359660-2	2020	The promoter responded linearly to a wide concentration range of at-RA in cells cotransfected with retinoic acid receptors (RAR).	Radium	68-70	retinoic acid receptor alpha	Homo sapiens	124-127
32359660-4	2020	An isolated clonal line of HEK293T cells that was permanently transfected with the promoter driving the expression of RFP responded to both at-RA and retinol, and the responses could be measured by fluorescence microscopy and flow cytometry.	Radium	143-145	tripartite motif containing 27	Homo sapiens	118-121
31146647-6	2020	Immunomodulation was assessed by measuring serum IgG anti-platelet antibody levels; TPO-RA-treated mice had significantly reduced IgG anti-platelet antibodies despite the increasing platelet counts.	Radium	88-90	thyroid peroxidase	Mus musculus	84-87
31280643-7	2020	After both two and six weeks of TPO-RA-treatment, ITP patients had higher MV-associated PS-activity and phospholipid-dependent thrombin generation in plasma than controls.	Radium	36-38	thyroid peroxidase	Homo sapiens	32-35
31280643-7	2020	After both two and six weeks of TPO-RA-treatment, ITP patients had higher MV-associated PS-activity and phospholipid-dependent thrombin generation in plasma than controls.	Radium	36-38	coagulation factor II, thrombin	Homo sapiens	127-135
32642730-5	2020	NF1 mutant neurofibroma SCs with elevated Ras-GTP signaling resemble injury-induced repair SCs, in producing growth factors and cytokines not normally present in SCs.	Radium	42-45	neurofibromin 1	Homo sapiens	0-3
31081041-10	2019	CONCLUSION: The results of the epigenetic qPCR assay showed that low levels of Th17 cells were predictive of developing RA, particularly in the ACPA-negative patients.	Radium	120-122	proteinase 3	Homo sapiens	144-148
31527569-15	2019	Positive feedback occurs between RA signaling and Pitx1.	Radium	33-35	paired like homeodomain 1	Homo sapiens	50-55
30649241-9	2019	LA and RA booster pump function were increased in the acute setting (LA-epsilona: P = 0.045, SRa: P = 0.002 and RA-epsilona: P = 0.004, SRa: P = 0.002 vs. controls).	Radium	7-9	steroid receptor RNA activator 1	Homo sapiens	93-96
31272231-3	2019	The variable RA is the normalized difference between L5 and M10 - the higher the RA, the greater the difference between these two variables.	Radium	13-15	ribosomal protein L5	Homo sapiens	53-55
31272231-3	2019	The variable RA is the normalized difference between L5 and M10 - the higher the RA, the greater the difference between these two variables.	Radium	81-83	ribosomal protein L5	Homo sapiens	53-55
30649241-9	2019	LA and RA booster pump function were increased in the acute setting (LA-epsilona: P = 0.045, SRa: P = 0.002 and RA-epsilona: P = 0.004, SRa: P = 0.002 vs. controls).	Radium	7-9	steroid receptor RNA activator 1	Homo sapiens	136-139
31037524-15	2019	Moreover, the expression of apoptosis-related proteins, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), were decreased with RA treatment.	Radium	143-145	poly (ADP-ribose) polymerase 1	Rattus norvegicus	86-114
31482833-7	2019	The mean age of infants at the time of RA-PSG was 13.0 +- 11.7 weeks and at O2-PSG was 15.4 +- 13.0 weeks.	Radium	39-41	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	42-45
31482833-8	2019	The obstructive AHI decreased from 19.7 +- 13.0 during RA-PSG to 10.6 +- 11.7 during O2-PSG (P < .001).	Radium	55-57	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	58-61
31390367-7	2019	To follow up on these observations, we immunoprecipitated endogenous RAS from HEK293T cells, conducted mass spectrometric analysis and found that RAS residues, Lys-5 and Lys-147, undergo dimethylation and monomethylation, respectively.	Radium	69-72	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	160-165
30753643-0	2019	Has TNF inhibitor use decreased the need for total hip and total knee replacement for patients with RA?	Radium	100-102	tumor necrosis factor	Homo sapiens	4-7
31160794-0	2019	ACPA-negative RA divided into clinical subsets.	Radium	14-16	proteinase 3	Homo sapiens	0-4
31358819-2	2019	In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras binding to the Ras binding domain (RBD) of Raf.	Radium	131-134	mitogen-activated protein kinase 3	Homo sapiens	96-102
31164691-0	2019	Znf703 is a novel RA target in the neural plate border.	Radium	18-20	zinc finger protein 703	Homo sapiens	0-6
31092459-9	2019	CONCLUSION: ALP and BAP levels and BSI values are suitable evaluation markers during treatment with Ra-223.	Radium	100-102	alkaline phosphatase, placental	Homo sapiens	12-15
30928092-4	2019	Herein the results indicated that RA-XII reduced the cell motility by decreasing the expressions of beta-catenin and beta-catenin dependent proteins CD44 and MMP7 in HCT116 cells.	Radium	34-36	catenin beta 1	Homo sapiens	100-112
30928092-4	2019	Herein the results indicated that RA-XII reduced the cell motility by decreasing the expressions of beta-catenin and beta-catenin dependent proteins CD44 and MMP7 in HCT116 cells.	Radium	34-36	catenin beta 1	Homo sapiens	117-129
30928092-4	2019	Herein the results indicated that RA-XII reduced the cell motility by decreasing the expressions of beta-catenin and beta-catenin dependent proteins CD44 and MMP7 in HCT116 cells.	Radium	34-36	CD44 molecule (Indian blood group)	Homo sapiens	149-153
30928092-4	2019	Herein the results indicated that RA-XII reduced the cell motility by decreasing the expressions of beta-catenin and beta-catenin dependent proteins CD44 and MMP7 in HCT116 cells.	Radium	34-36	matrix metallopeptidase 7	Homo sapiens	158-162
30928092-6	2019	Moreover the decreased cell motility caused by RA-XII was attenuated with the SREBP-1 knockdown.	Radium	47-49	sterol regulatory element binding transcription factor 1	Homo sapiens	78-85
30786725-5	2019	RESULTS: In total, data from 8 trials and 77 242 patients, 42 920 (55.6%) in GLP1-RA trials, and 34 322 (44.4%) in SGLT2i trials, were included.	Radium	82-84	glucagon like peptide 1 receptor	Homo sapiens	77-81
30733287-5	2019	The structure reveals that the IN segment associates with the RA segment and thereby suppresses RIAM:RAP1 association.	Radium	62-64	amyloid beta precursor protein binding family B member 1 interacting protein	Homo sapiens	96-100
30743272-6	2019	The patients with ITP undergoing TPO-RA therapy presented a pro-coagulant profile due to the formation of a more fibrinolysis-resistant clot because of increased plasminogen activator inhibitor-1 (PAI-1) levels.	Radium	37-39	thyroid peroxidase	Homo sapiens	33-36
30743272-6	2019	The patients with ITP undergoing TPO-RA therapy presented a pro-coagulant profile due to the formation of a more fibrinolysis-resistant clot because of increased plasminogen activator inhibitor-1 (PAI-1) levels.	Radium	37-39	serpin family E member 1	Homo sapiens	162-195
30743272-6	2019	The patients with ITP undergoing TPO-RA therapy presented a pro-coagulant profile due to the formation of a more fibrinolysis-resistant clot because of increased plasminogen activator inhibitor-1 (PAI-1) levels.	Radium	37-39	serpin family E member 1	Homo sapiens	197-202
30743272-8	2019	Moreover, patients under TPO-RA treatment presented an enhanced pro-coagulant activity associated with microparticles and an increased platelet apoptosis that causes a higher exposure of phosphatidylserine and, consequently, a larger surface for the binding of the prothrombinase complex.	Radium	29-31	thyroid peroxidase	Homo sapiens	25-28
30383455-14	2019	VEGF levels were higher in P13 OIR mice than RA mice (p < 0.0001).	Radium	45-47	vascular endothelial growth factor A	Mus musculus	0-4
30733287-5	2019	The structure reveals that the IN segment associates with the RA segment and thereby suppresses RIAM:RAP1 association.	Radium	62-64	TERF2 interacting protein	Homo sapiens	101-105
30867811-6	2019	Consequently, Knockdown of ISL1 inhibits neuroblastoma cell proliferation and migration in vitro and impedes tumor growth in vivo, and enhances neuronal differentiation by RA treatment.	Radium	172-174	ISL LIM homeobox 1	Homo sapiens	27-31
30599075-6	2019	Meanwhile, we showed that miR-21 activated the PI3K/AKT signaling pathway to participate in RA by inhibiting PTEN expression.	Radium	92-94	microRNA 21	Homo sapiens	26-32
30599075-6	2019	Meanwhile, we showed that miR-21 activated the PI3K/AKT signaling pathway to participate in RA by inhibiting PTEN expression.	Radium	92-94	AKT serine/threonine kinase 1	Homo sapiens	52-55
30599075-6	2019	Meanwhile, we showed that miR-21 activated the PI3K/AKT signaling pathway to participate in RA by inhibiting PTEN expression.	Radium	92-94	phosphatase and tensin homolog	Homo sapiens	109-113
30723587-2	2019	The LXR ligands/oxysterols and the RXR ligand 9-cis Retinoic Acid (9-cis RA) were shown to dampen DC migration to lymphoid organs through the inhibition of CCR7 expression.	Radium	73-75	nuclear receptor subfamily 1, group H, member 3	Mus musculus	4-7
30391675-5	2019	The elevated RRAD expression was then confirmed in senescent human fibroblasts that were induced by Ras, H2O2, ionizing radiation, hydroxyurea, etoposide and replicative passage, respectively.	Radium	100-103	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	13-17
30663507-3	2019	The data showed that such RA forms of Abs are able to modulate the antibody interaction with interferon gamma, and it was suggested that the observed influence of RA forms of Abs on "antibody-antigen" interaction could be used to analyze the activity of this kind of drugs.	Radium	26-28	interferon gamma	Homo sapiens	93-109
30663507-3	2019	The data showed that such RA forms of Abs are able to modulate the antibody interaction with interferon gamma, and it was suggested that the observed influence of RA forms of Abs on "antibody-antigen" interaction could be used to analyze the activity of this kind of drugs.	Radium	163-165	interferon gamma	Homo sapiens	93-109
29215956-2	2019	Previous long-term TPO-RA clinical trials have shown that thrombotic events occurred in 6% of TPO-RA-treated ITP patients.	Radium	23-25	thyroid peroxidase	Homo sapiens	19-22
29215956-2	2019	Previous long-term TPO-RA clinical trials have shown that thrombotic events occurred in 6% of TPO-RA-treated ITP patients.	Radium	23-25	thyroid peroxidase	Homo sapiens	94-97
29215956-2	2019	Previous long-term TPO-RA clinical trials have shown that thrombotic events occurred in 6% of TPO-RA-treated ITP patients.	Radium	98-100	thyroid peroxidase	Homo sapiens	19-22
29215956-2	2019	Previous long-term TPO-RA clinical trials have shown that thrombotic events occurred in 6% of TPO-RA-treated ITP patients.	Radium	98-100	thyroid peroxidase	Homo sapiens	94-97
29215956-9	2019	Significantly higher levels of F1+2, D-dimer, and PAI-1 were found in ITP patients before TPO-RA treatment and in patients on long-term TPO-RA treatment than in controls.	Radium	94-96	serpin family E member 1	Homo sapiens	50-55
29215956-9	2019	Significantly higher levels of F1+2, D-dimer, and PAI-1 were found in ITP patients before TPO-RA treatment and in patients on long-term TPO-RA treatment than in controls.	Radium	94-96	thyroid peroxidase	Homo sapiens	90-93
29293383-12	2019	During TPO-RA treatment for up to 2 years, this profile was partially reversed while mild BM reticulin fibrosis was still present in the majority of patients.	Radium	11-13	thyroid peroxidase	Homo sapiens	7-10
30204915-11	2019	These findings suggest PIM-1 as a novel regulator of the aggressive and invasive behaviour of RA-FLSs and indicate its potential as a target for RA treatment.	Radium	94-96	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	23-28
30723587-2	2019	The LXR ligands/oxysterols and the RXR ligand 9-cis Retinoic Acid (9-cis RA) were shown to dampen DC migration to lymphoid organs through the inhibition of CCR7 expression.	Radium	73-75	chemokine (C-C motif) receptor 7	Mus musculus	156-160
30551225-6	2018	Analytical evidence for the presence of radium-calixarene species by means of activity measurement, TLC as well as HPLC could not been proven unambiguously.	Radium	40-46	lipocalin 1	Homo sapiens	100-103
30222957-6	2018	Exogenous RA signaling activation in the Ezh2 mutants leads to synergistic activation of the anti-osteogenic factors in the cranial mesenchyme in vivo.	Radium	10-12	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	41-45
30643060-9	2018	After IR, the expression of MMP9 in the lung tissues in the IR group and the RA group increased significantly (both P&lt;0.01).	Radium	77-79	matrix metallopeptidase 9	Rattus norvegicus	28-32
30643060-10	2018	The expression of MMP-9 protein in the RA group was significantly lower than that in the IR group (P&lt;0.01).	Radium	39-41	matrix metallopeptidase 9	Rattus norvegicus	18-23
30120083-5	2018	OUTCOMES: Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17).	Radium	64-66	neurofascin	Homo sapiens	95-106
30533262-10	2018	However, RA treatment decreased the levels of p-ATM, p-p53, GADD45alpha, p21, MMP-3, -9, and -13 and increased the level of COL1A1 in a concentration-dependent manner.	Radium	9-11	tumor protein p53	Homo sapiens	55-58
30533262-10	2018	However, RA treatment decreased the levels of p-ATM, p-p53, GADD45alpha, p21, MMP-3, -9, and -13 and increased the level of COL1A1 in a concentration-dependent manner.	Radium	9-11	growth arrest and DNA damage inducible alpha	Homo sapiens	60-71
30533262-10	2018	However, RA treatment decreased the levels of p-ATM, p-p53, GADD45alpha, p21, MMP-3, -9, and -13 and increased the level of COL1A1 in a concentration-dependent manner.	Radium	9-11	H3 histone pseudogene 16	Homo sapiens	73-76
30533262-10	2018	However, RA treatment decreased the levels of p-ATM, p-p53, GADD45alpha, p21, MMP-3, -9, and -13 and increased the level of COL1A1 in a concentration-dependent manner.	Radium	9-11	matrix metallopeptidase 3	Homo sapiens	78-96
30533262-10	2018	However, RA treatment decreased the levels of p-ATM, p-p53, GADD45alpha, p21, MMP-3, -9, and -13 and increased the level of COL1A1 in a concentration-dependent manner.	Radium	9-11	collagen type I alpha 1 chain	Homo sapiens	124-130
29957465-11	2018	In addition, by comparing RA rats and RA + NF-kappaB rats, we found that TNF-alpha stimulation exacerbated RA, increased expression levels of p-IkappaBalpha, p-p65, IL-1beta, IL-6, and IL-17, and decreased the expression level of IL-10.	Radium	26-28	tumor necrosis factor	Rattus norvegicus	73-82
30289535-4	2018	The increasing use of TNF inhibitors has not only improved the management of RA, but it has also helped in our understanding of the pathogenetic mechanisms of the disease.	Radium	77-79	tumor necrosis factor	Homo sapiens	22-25
30259238-7	2018	Structural differences among GLP-1 mimetics and analogs may explain potency differences in both A1C reduction and weight loss that may parallel important cardiovascular protective properties of the GLP-1 RA class.	Radium	204-206	glucagon	Homo sapiens	29-34
30259238-7	2018	Structural differences among GLP-1 mimetics and analogs may explain potency differences in both A1C reduction and weight loss that may parallel important cardiovascular protective properties of the GLP-1 RA class.	Radium	204-206	glucagon	Homo sapiens	198-203
30672201-10	2018	Compared with the model group, the expression of CK-MB and Beclin1 was decreased significantly in RA group, RB group, RC group and RD group (all P&lt;0.05), but the expression of Bcl-2 was significantly increased (all P&lt;0.05).	Radium	98-100	beclin 1	Rattus norvegicus	59-66
30672201-11	2018	Compared with the RA group, the expression of CK-MB was decreased in the RB group and RC group (both P&lt;0.05) but the expression of Bcl-2 was increased (both P&lt;0.01); the expression was not significantly different from that in the RD group (P&gt;0.05); the increasing of Bcl-2 in the RB group was more significant than that in RC group (P&lt;0.05).	Radium	18-20	BCL2, apoptosis regulator	Rattus norvegicus	134-139
30672201-11	2018	Compared with the RA group, the expression of CK-MB was decreased in the RB group and RC group (both P&lt;0.05) but the expression of Bcl-2 was increased (both P&lt;0.01); the expression was not significantly different from that in the RD group (P&gt;0.05); the increasing of Bcl-2 in the RB group was more significant than that in RC group (P&lt;0.05).	Radium	18-20	BCL2, apoptosis regulator	Rattus norvegicus	276-281
30672201-12	2018	The expression of Beclin 1 in the RB group was significantly lower than that in the RA group (P&lt;0.05), but there was no significant difference among other EA groups (all P&gt;0.05).	Radium	84-86	beclin 1	Rattus norvegicus	18-26
29967194-6	2018	RESULTS: We found a strong enrichment of significant interactions (AP p&lt;0.05) between the HLA-DRB1 SE alleles and the group of SNPs associated with ACPA-positive RA in both cohorts (Kolmogorov-Smirnov test D=0.35 for EIRA and D=0.25 for NARAC, p&lt;2.2e-16 for both).	Radium	165-167	major histocompatibility complex, class II, DR beta 1	Homo sapiens	93-101
29890139-5	2018	RA treatment suppressed the alpha-MSH-stimulated increase of melanogenesis and down-regulated the expression of tyrosinase and TRP1 proteins in B16F1 cells.	Radium	0-2	pro-opiomelanocortin-alpha	Mus musculus	28-37
29890139-5	2018	RA treatment suppressed the alpha-MSH-stimulated increase of melanogenesis and down-regulated the expression of tyrosinase and TRP1 proteins in B16F1 cells.	Radium	0-2	tyrosinase	Mus musculus	112-122
29890139-5	2018	RA treatment suppressed the alpha-MSH-stimulated increase of melanogenesis and down-regulated the expression of tyrosinase and TRP1 proteins in B16F1 cells.	Radium	0-2	tyrosinase-related protein 1	Mus musculus	127-131
29890139-7	2018	Inhibition of autophagy reduced the anti-melanogenic activity of RA in alpha-MSH-treated B16F1 cells.	Radium	65-67	pro-opiomelanocortin-alpha	Mus musculus	71-80
30048325-11	2018	The risk of delirium decreased by 24% per day per patient with use of RA (IRR 0.76, 95% CI 0.61 to 0.96).	Radium	70-72	insulin receptor related receptor	Homo sapiens	74-77
30120083-5	2018	OUTCOMES: Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17).	Radium	64-66	neurofascin	Homo sapiens	108-113
30120083-5	2018	OUTCOMES: Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17).	Radium	64-66	solute carrier family 25 member 17	Homo sapiens	119-153
29981365-4	2018	All-trans retinoic acid (ATRA), the biologically active metabolite of vitamin A/RA, has been shown to have pleiotropic effects on hematopoietic cells, enhancing HSC self-renewal while also increasing differentiation of more mature progenitors.	Radium	27-29	fucosyltransferase 1 (H blood group)	Homo sapiens	161-164
30120083-5	2018	OUTCOMES: Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17).	Radium	64-66	solute carrier family 25 member 17	Homo sapiens	155-163
29683208-7	2018	Based on Ras Pull-Down Assays, CMC2.24 inhibited Ras-GTP, the active form of Ras, in MIA PaCa-2 cells and in pancreatic acinar explants isolated from Kras mutant mice, by 90.3% and 89.1%, respectively (P &lt; 0.01, for both).	Radium	9-12	C-X9-C motif containing 2	Homo sapiens	31-35
30214105-9	2018	Results: The mRNA expressions of the SOX10, MBP, and MBP gene were significantly increased in the treated groups compared with the negative control group; the increase was similar in the 9-cis-RA group and the positive control group.	Radium	193-195	SRY-box transcription factor 10	Rattus norvegicus	37-42
28603283-8	2018	Taken together, by linking HSC70 and NF-kappaB signaling, TXNDC5 plays a pro-inflammatory role in RASFs, highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction.	Radium	98-100	heat shock protein family A (Hsp70) member 8	Homo sapiens	27-32
30102701-5	2018	Further studies demonstrated that Wdr62 is required for RA-induced Stra8 expression via the activation of JNK signaling, and the defects in meiotic initiation from Wdr62-deficient female mice could be partially rescued by JNK1 overexpression in germ cells.	Radium	56-58	mitogen-activated protein kinase 8	Mus musculus	106-109
30102701-5	2018	Further studies demonstrated that Wdr62 is required for RA-induced Stra8 expression via the activation of JNK signaling, and the defects in meiotic initiation from Wdr62-deficient female mice could be partially rescued by JNK1 overexpression in germ cells.	Radium	56-58	mitogen-activated protein kinase 8	Mus musculus	222-226
30104724-5	2018	Our findings illuminate a critical function for SHP2 in promoting oncogenic RAS/MAPK pathway activation in cancers with RAS-GTP-dependent oncogenic BRAF, NF1 loss and nucleotide-cycling oncogenic KRAS.	Radium	76-79	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	48-52
30102701-5	2018	Further studies demonstrated that Wdr62 is required for RA-induced Stra8 expression via the activation of JNK signaling, and the defects in meiotic initiation from Wdr62-deficient female mice could be partially rescued by JNK1 overexpression in germ cells.	Radium	56-58	WD repeat domain 62	Mus musculus	34-39
30102701-5	2018	Further studies demonstrated that Wdr62 is required for RA-induced Stra8 expression via the activation of JNK signaling, and the defects in meiotic initiation from Wdr62-deficient female mice could be partially rescued by JNK1 overexpression in germ cells.	Radium	56-58	stimulated by retinoic acid gene 8	Mus musculus	67-72
28603283-8	2018	Taken together, by linking HSC70 and NF-kappaB signaling, TXNDC5 plays a pro-inflammatory role in RASFs, highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction.	Radium	98-100	thioredoxin domain containing 5	Homo sapiens	58-64
28603283-8	2018	Taken together, by linking HSC70 and NF-kappaB signaling, TXNDC5 plays a pro-inflammatory role in RASFs, highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction.	Radium	98-100	thioredoxin domain containing 5	Homo sapiens	167-173
28603283-8	2018	Taken together, by linking HSC70 and NF-kappaB signaling, TXNDC5 plays a pro-inflammatory role in RASFs, highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction.	Radium	98-100	heat shock protein family A (Hsp70) member 8	Homo sapiens	174-179
29549724-10	2018	Overall, our findings suggest that BBR is a potential candidate for therapeutic targeting of IL-21/IL-21R mediated RA pathogenesis.	Radium	115-117	interleukin 21	Rattus norvegicus	93-98
29549724-10	2018	Overall, our findings suggest that BBR is a potential candidate for therapeutic targeting of IL-21/IL-21R mediated RA pathogenesis.	Radium	115-117	interleukin 21 receptor	Rattus norvegicus	99-105
29491073-6	2018	Back-to-back oocyte retrieval and RA-TLH with BSO are not only feasible, but could also decrease significant anesthetic risks for morbidly obese patients.	Radium	34-36	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	37-40
29522756-9	2018	Activation of Hoxd4 mRNA using transretinoic acid (RA) resulted in 18-fold increase of UII mRNA expression in CNSS and high locomotor activity in medaka, confirming that Hoxd4 is also involved in UII gene transcriptional regulation.	Radium	51-53	hoxd4	Oryzias latipes	14-19
29522756-9	2018	Activation of Hoxd4 mRNA using transretinoic acid (RA) resulted in 18-fold increase of UII mRNA expression in CNSS and high locomotor activity in medaka, confirming that Hoxd4 is also involved in UII gene transcriptional regulation.	Radium	51-53	hoxd4	Oryzias latipes	170-175
29440291-8	2018	Furthermore, in cells expressing either S1178A SOS1 or a constitutively membrane-bound CAAX box tagged SOS1 mutant, we observed elevated RAS-GTP levels over time in response to compound, as compared with the biphasic changes in RAS-GTP exhibited in cells expressing wild-type SOS1.	Radium	137-140	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	47-51
29440291-8	2018	Furthermore, in cells expressing either S1178A SOS1 or a constitutively membrane-bound CAAX box tagged SOS1 mutant, we observed elevated RAS-GTP levels over time in response to compound, as compared with the biphasic changes in RAS-GTP exhibited in cells expressing wild-type SOS1.	Radium	137-140	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	103-107
29440291-8	2018	Furthermore, in cells expressing either S1178A SOS1 or a constitutively membrane-bound CAAX box tagged SOS1 mutant, we observed elevated RAS-GTP levels over time in response to compound, as compared with the biphasic changes in RAS-GTP exhibited in cells expressing wild-type SOS1.	Radium	137-140	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	103-107
29482449-4	2018	Using retinoid acid (RA)-induced SMC differentiation models, we observed that p53 expression is increased during in vitro differentiation of mouse ESCs into SMCs.	Radium	21-23	transformation related protein 53	Mus musculus	78-81
29642915-11	2018	The RBP4 action is depend on its associated ligand vitamin A/retinol acid (RA) and possibly involves similar pathways as for conferring insulin resistance.	Radium	75-77	retinol binding protein 4	Homo sapiens	4-8
29319370-1	2018	OBJECTIVE: To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals.	Radium	165-167	CD226 molecule	Homo sapiens	41-46
29319370-3	2018	RESULTS: Significant association with RA was found with CD226 T allele (OR (95%CI) = 1.6 (1.04-2.4), P = 0.032), and higher CD226 serum level (P = 0.001).	Radium	38-40	CD226 molecule	Homo sapiens	56-61
29319370-3	2018	RESULTS: Significant association with RA was found with CD226 T allele (OR (95%CI) = 1.6 (1.04-2.4), P = 0.032), and higher CD226 serum level (P = 0.001).	Radium	38-40	CD226 molecule	Homo sapiens	124-129
29319370-7	2018	CONCLUSION: The CD226 T allele may be susceptibility risk factors for the development of RA and the higher serum level of CD226 may be involved in the pathogenesis of RA in Egyptian patients.	Radium	89-91	CD226 molecule	Homo sapiens	16-21
29319370-7	2018	CONCLUSION: The CD226 T allele may be susceptibility risk factors for the development of RA and the higher serum level of CD226 may be involved in the pathogenesis of RA in Egyptian patients.	Radium	167-169	CD226 molecule	Homo sapiens	122-127
29628894-6	2018	Results: IRS2-/- RA exhibited normal vasomotor function, yet a decreased maximal diameter compared to IRS2+/+ RA.	Radium	17-19	insulin receptor substrate 2	Mus musculus	9-13
29628894-12	2018	Insulin-induced AKT phosphorylation in RA was similar in the presence of IRS2-/- and IRS2+/+ PVAT.	Radium	39-41	insulin receptor substrate 2	Mus musculus	85-89
29743862-4	2018	Histone acetylation in the regulatory region of CYP1A1 was enhanced by treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or all-trans retinoic acid (at-RA).	Radium	160-162	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
29872770-9	2018	At the protein level, there was increased cleaved caspase-3 but decreased procaspase-3 expression in Met-, 9-cis RA- and Met+9-cis RA-treated C6 GSCs, as detected by western blotting.	Radium	113-115	caspase 3	Homo sapiens	74-86
29872770-10	2018	The ratio of cleaved caspase-3/procaspase-3 was 1.6 times higher in Met+9-cis RA-treated groups compared to control.	Radium	78-80	caspase 3	Homo sapiens	21-30
29872770-10	2018	The ratio of cleaved caspase-3/procaspase-3 was 1.6 times higher in Met+9-cis RA-treated groups compared to control.	Radium	78-80	caspase 3	Homo sapiens	31-43
29334210-13	2018	The bFGF+RA group had higher rate (83 +- 1.52) of two-cells development, than control (33 +- 1, P&lt;0.001).	Radium	9-11	fibroblast growth factor 2	Mus musculus	4-8
29305158-4	2018	This repressive action on RA signaling was functionally confirmed by the decrease of RA-mediated neuronal differentiation in neural stem cells stably overexpressing TBR2.	Radium	26-28	eomesodermin	Homo sapiens	165-169
28696795-7	2018	RESULTS: CEP70 was expressed predominantly in the superficial lining layer in RA synovial tissue.	Radium	78-80	centrosomal protein 70	Homo sapiens	9-14
29305158-4	2018	This repressive action on RA signaling was functionally confirmed by the decrease of RA-mediated neuronal differentiation in neural stem cells stably overexpressing TBR2.	Radium	85-87	eomesodermin	Homo sapiens	165-169
29305158-8	2018	Indeed, we found ZFP423 to be expressed in the developing cortex and promote RA-dependent neuronal differentiation.	Radium	77-79	zinc finger protein 423	Homo sapiens	17-23
29305158-9	2018	These data indicate that TBR2 contributes to suppressing RA signaling in INPs, thereby enabling them to re-enter the cell cycle and delay neuronal differentiation.	Radium	57-59	eomesodermin	Homo sapiens	25-29
28905300-7	2017	Treatment of RA after overstretch injury with antagonists to purinergic P2X7 receptor (P2X7R) antagonists or P2X7R/pannexin (PanX1) complex, but not PanX1 alone, restored vasomotor function.	Radium	13-15	Pannexin 1	Rattus norvegicus	125-130
28983953-9	2018	We confirm the efficacy of TPO-RA switch; once achieved, response to the 2nd TPO-RA seems durable.	Radium	31-33	thyroid peroxidase	Homo sapiens	27-30
28983953-9	2018	We confirm the efficacy of TPO-RA switch; once achieved, response to the 2nd TPO-RA seems durable.	Radium	31-33	thyroid peroxidase	Homo sapiens	77-80
28983953-9	2018	We confirm the efficacy of TPO-RA switch; once achieved, response to the 2nd TPO-RA seems durable.	Radium	81-83	thyroid peroxidase	Homo sapiens	27-30
28983953-9	2018	We confirm the efficacy of TPO-RA switch; once achieved, response to the 2nd TPO-RA seems durable.	Radium	81-83	thyroid peroxidase	Homo sapiens	77-80
30526305-6	2018	Although coexpression with MYC reduced certain RAS-induced senescence markers (histone H3 lysine 9 trimethylation and senescence-associated beta-GAL activity), the induction of the senescence marker p16INK4A was further enhanced and the culture ceased to proliferate within a few days, revealing that MYC could not fully suppress RAS-induced senescence.	Radium	47-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-30
28121199-13	2017	Identification of this CTL1- and CTL2-mediated choline transport system should provide a potential new target for RA therapy.	Radium	114-116	solute carrier family 44 member 1	Homo sapiens	23-27
28121199-13	2017	Identification of this CTL1- and CTL2-mediated choline transport system should provide a potential new target for RA therapy.	Radium	114-116	solute carrier family 44 member 2	Homo sapiens	33-37
28687611-3	2017	A screening campaign revealed retinol (vitamin A alcohol) and all-trans retinoic acid (vitamin A acid) (RA) as hits that time-dependently (&gt;=24 h) deplete phosphatidylcholine-bound polyunsaturated fatty acids (PUFA-PCs) from NIH-3T3 mouse fibroblasts while inducing Akt activation (EC50   0.1-1 microM).	Radium	104-106	thymoma viral proto-oncogene 1	Mus musculus	269-272
29085766-4	2017	These descriptors correlate with the anti-RA activity with R2 values for JAK3, JAK2 and JAK1 are 0.9811, 0.8620 and 0.9740, respectively.	Radium	42-44	Janus kinase 3	Homo sapiens	73-77
29085766-4	2017	These descriptors correlate with the anti-RA activity with R2 values for JAK3, JAK2 and JAK1 are 0.9811, 0.8620 and 0.9740, respectively.	Radium	42-44	Janus kinase 2	Homo sapiens	79-83
29085766-4	2017	These descriptors correlate with the anti-RA activity with R2 values for JAK3, JAK2 and JAK1 are 0.9811, 0.8620 and 0.9740, respectively.	Radium	42-44	Janus kinase 1	Homo sapiens	88-92
28810523-13	2017	Altogether, these findings suggested XAN-induced ROS contributed great importance to the proliferation inhibition of HFLS-RA cells by mediating NF-kappaB/p38 feedback loop and apoptosis, which provided us a panoramic view of potential target in the therapy of RA by XAN.	Radium	122-124	nuclear factor kappa B subunit 1	Homo sapiens	144-153
28810523-13	2017	Altogether, these findings suggested XAN-induced ROS contributed great importance to the proliferation inhibition of HFLS-RA cells by mediating NF-kappaB/p38 feedback loop and apoptosis, which provided us a panoramic view of potential target in the therapy of RA by XAN.	Radium	122-124	mitogen-activated protein kinase 14	Homo sapiens	154-157
28687611-5	2017	Organized in a coregulated phospholipid subcluster, PUFA-PCs compensated for the RA-induced loss of cellular PUFA-PCs and diminished Akt activation when supplemented.	Radium	81-83	thymoma viral proto-oncogene 1	Mus musculus	133-136
28687611-6	2017	The counter-regulation of phospholipids and Akt by RA was mimicked by knockdown of lysophosphatidylcholine acyltransferase-3 or the selective retinoid X receptor (RXR) agonist bexarotene and prevented by the selective RXR antagonist Hx531.	Radium	51-53	thymoma viral proto-oncogene 1	Mus musculus	44-47
28687611-6	2017	The counter-regulation of phospholipids and Akt by RA was mimicked by knockdown of lysophosphatidylcholine acyltransferase-3 or the selective retinoid X receptor (RXR) agonist bexarotene and prevented by the selective RXR antagonist Hx531.	Radium	51-53	lysophosphatidylcholine acyltransferase 3	Mus musculus	83-124
28687611-8	2017	Together, our findings show that RA regulates the long-term activation of Akt by changes in the phospholipid composition.-Pein, H., Koeberle, S. C., Voelkel, M., Schneider, F., Rossi, A., Thurmer, M., Loeser, K., Sautebin, L., Morrison, H., Werz, O., Koeberle, A.	Radium	33-35	thymoma viral proto-oncogene 1	Mus musculus	74-77
28938465-7	2017	Insulin sensitivity of glucose production (Ra) was measured by the euglycemic hyperinsulinemic clamp technique in which a low insulin dose (0.4 mU/kg/min for 240 minutes) was combined with D-[3-3H] glucose infusion to measure rates of Ra and utilization and insulin action on antilipolysis from suppression of serum free fatty acids.	Radium	43-45	insulin	Homo sapiens	0-7
28483913-7	2017	Moreover, our results also show that RA induction of RAR target genes is suppressed by the ERK pathway activation.	Radium	37-39	retinoic acid receptor alpha	Homo sapiens	53-56
28645068-9	2017	In comparison of all applied fabrication process routes, it is found that CAD/CAM milling followed by polishing and sintering produced the smoothest surface with Ra = 0.12 +- 0.08microm and Rz = 0.89 +- 0.26microm.	Radium	162-164	calmodulin 3	Homo sapiens	78-81
28886103-4	2017	We show that the promoter of the human SOX3 gene is extremely hypomethylated both in undifferentiated NT2/D1 cells and during the early phases of RA-induced neural differentiation.	Radium	146-148	SRY-box transcription factor 3	Homo sapiens	39-43
28570942-6	2017	RA treatment-induced increase in RARalpha, Src and NR1 expressions in mVAD neurons was much lower than that in VAN neurons.	Radium	0-2	retinoic acid receptor, alpha	Rattus norvegicus	33-41
28570942-6	2017	RA treatment-induced increase in RARalpha, Src and NR1 expressions in mVAD neurons was much lower than that in VAN neurons.	Radium	0-2	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	43-46
28570942-6	2017	RA treatment-induced increase in RARalpha, Src and NR1 expressions in mVAD neurons was much lower than that in VAN neurons.	Radium	0-2	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	51-54
29696196-2	2017	Recent studies indicated that baseline serum TNF-alpha could be considered as a key indicator for optimal dosing of infliximab for RA treatment to achieve the clinical response and its sustained remission.	Radium	131-133	tumor necrosis factor	Homo sapiens	45-54
28549973-5	2017	An increase in the concentration of CRM197 and ApoE decreased the transendothelial electrical resistance and increased the ability of propidium iodide and RA to cross the BBB.	Radium	155-157	apolipoprotein E	Homo sapiens	47-51
29029510-3	2017	Semaphorin 3A (Sema3A) is recently identified as an essential player in the bone homeostasis, however its role in RA progression especially in the macrophage polarization are poorly understood.	Radium	114-116	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	0-13
29029510-3	2017	Semaphorin 3A (Sema3A) is recently identified as an essential player in the bone homeostasis, however its role in RA progression especially in the macrophage polarization are poorly understood.	Radium	114-116	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	15-21
28660910-0	2017	Rheumatoid arthritis: ACPA status influences RA development.	Radium	45-47	proteinase 3	Homo sapiens	22-26
28963484-5	2017	All these changes facilitate ADP-RA to bind ARH1.	Radium	33-35	ADP-ribosylarginine hydrolase	Homo sapiens	44-48
28855513-4	2017	In this biosensor, two inactive luciferase fragments are sandwiched by Raf-1, whose conformation changes upon GTP-Ras binding.	Radium	114-117	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	71-76
28549973-7	2017	Thus, CRM197-ApoE-RA-PAAM-CH-PLGA NPs can be a promising formulation to deliver RA to Abeta-insulted neurons in the pharmacotherapy of Alzheimer"s disease.	Radium	18-20	apolipoprotein E	Homo sapiens	13-17
28483913-7	2017	Moreover, our results also show that RA induction of RAR target genes is suppressed by the ERK pathway activation.	Radium	37-39	mitogen-activated protein kinase 1	Homo sapiens	91-94
27469144-13	2017	In conclusion, RA augmented pentobarbital-induced sleeping behaviors through GABAA-ergic transmission.	Radium	15-17	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	77-82
28388567-5	2017	The generated pharmacophore model revealed that the one RA, three Hyd, and two HBA features play an important role in binding to the active site of the target protein-PTP-MEG2.	Radium	56-58	protein tyrosine phosphatase non-receptor type 9	Homo sapiens	167-175
28379210-1	2017	AIM: The study has two aims: 1) to evaluate the association of IL-17 polymorphism rs2275913 with RA severity and 2) to evaluate if this particular SNP is associated with susceptibility for RA in Mexican patients.	Radium	97-99	interleukin 17A	Homo sapiens	63-68
28628642-7	2017	CA-4 decreased Ra and Rq values in sensitive cells but increased these values in resistant cells.	Radium	15-17	carbonic anhydrase 4	Homo sapiens	0-4
28430414-6	2017	The local stability of each rA-dT base pair within the tract is the same as that of the corresponding rA-rU base pair in the homologous RNA-only duplex but differs from the stabilities of dA-dT and dA-rU base pairs in the other two duplexes (namely, dA-dT &gt; rA-dT &gt; dA-rU).	Radium	28-30	arouser	Drosophila melanogaster	198-203
28430414-6	2017	The local stability of each rA-dT base pair within the tract is the same as that of the corresponding rA-rU base pair in the homologous RNA-only duplex but differs from the stabilities of dA-dT and dA-rU base pairs in the other two duplexes (namely, dA-dT &gt; rA-dT &gt; dA-rU).	Radium	28-30	arouser	Drosophila melanogaster	272-277
28446218-7	2017	RESULTS: Galectin-3 was increased in pre-rheumatoid arthritis (RA) (4.6 mug/l, interquartile range (IQR) 3.8-5.5) versus non-RA (4.0 mug/l, IQR 3.1-4.9; p = 0.03) and controls (3.8 mug/l, IQR 3.0-4.8; p = 0.009).	Radium	63-65	galectin 3	Homo sapiens	9-19
28171867-15	2017	CONCLUSION: The IL-6 (-174) GC genotype is associated with a smaller C/D ratio, larger RA, and thicker RNFL compared with IL-6 (-174) GG in NTG patients.	Radium	87-89	interleukin 6	Homo sapiens	16-20
27930985-9	2017	Down-regulation of FGFR1 attenuated the increase in Ras-GTP expression caused by IL-1beta stimulation.	Radium	52-55	fibroblast growth factor receptor 1	Homo sapiens	19-24
27930985-9	2017	Down-regulation of FGFR1 attenuated the increase in Ras-GTP expression caused by IL-1beta stimulation.	Radium	52-55	interleukin 1 beta	Homo sapiens	81-89
28054709-6	2017	SARAH binds RA and blocks the interaction between RA and MDM2.	Radium	12-14	MDM2 proto-oncogene	Homo sapiens	57-61
28054709-8	2017	In the presence of active KRas, the interaction between RA and MDM2 is recovered.	Radium	56-58	MDM2 proto-oncogene	Homo sapiens	63-67
28167758-6	2017	RARalpha and RXRalpha serve as a "director" and an "enhancer," respectively, to enhance RARalpha binding to RA-responsive element (RARE) and hence miR-10a expression, thus down-regulating GATA6/VCAM-1 signaling in ECs.	Radium	0-2	retinoic acid receptor, alpha	Rattus norvegicus	88-96
28167758-6	2017	RARalpha and RXRalpha serve as a "director" and an "enhancer," respectively, to enhance RARalpha binding to RA-responsive element (RARE) and hence miR-10a expression, thus down-regulating GATA6/VCAM-1 signaling in ECs.	Radium	0-2	microRNA 10a	Rattus norvegicus	147-154
28167758-6	2017	RARalpha and RXRalpha serve as a "director" and an "enhancer," respectively, to enhance RARalpha binding to RA-responsive element (RARE) and hence miR-10a expression, thus down-regulating GATA6/VCAM-1 signaling in ECs.	Radium	0-2	GATA binding protein 6	Rattus norvegicus	188-193
28167758-6	2017	RARalpha and RXRalpha serve as a "director" and an "enhancer," respectively, to enhance RARalpha binding to RA-responsive element (RARE) and hence miR-10a expression, thus down-regulating GATA6/VCAM-1 signaling in ECs.	Radium	0-2	vascular cell adhesion molecule 1	Rattus norvegicus	194-200
27682653-7	2017	Finally, serum FGF23 levels, compared with the plasma BNP levels, were more strongly associated with the clinical outcomes in patients with above-median RA pressure.	Radium	153-155	fibroblast growth factor 23	Homo sapiens	15-20
27682653-8	2017	These findings suggested that serum FGF23 levels are predominantly correlated with clinical outcomes, may serve as a biomarker for HF in patients with higher RA pressure, may provide beneficial information for patients with right-sided HF and may represent different clinical information than that provided only by plasma BNP levels.	Radium	158-160	fibroblast growth factor 23	Homo sapiens	36-41
28107533-10	2017	Furthermore, the combined therapy with kakkonto reduced the expression of RA-degrading enzyme CYP26B1 mRNA in the FA mouse colon.	Radium	74-76	cytochrome P450, family 26, subfamily b, polypeptide 1	Mus musculus	94-101
28054709-5	2017	RA binds to the RING-finger region of MDM2 and stabilizes p53.	Radium	0-2	MDM2 proto-oncogene	Homo sapiens	38-42
28054709-5	2017	RA binds to the RING-finger region of MDM2 and stabilizes p53.	Radium	0-2	tumor protein p53	Homo sapiens	58-61
28054709-6	2017	SARAH binds RA and blocks the interaction between RA and MDM2.	Radium	2-4	MDM2 proto-oncogene	Homo sapiens	57-61
27809896-3	2016	To better understand the HLA-RA connection, we aimed to investigate if the enhanced capacity to present arginine-to-citrulline-converted peptides is unique for HLA-SE alleles.	Radium	29-31	major histocompatibility complex, class II, DR beta 1	Homo sapiens	25-28
28155679-5	2016	The RA in these models are 1 and 2, respectively; In the model B11 and B21, the entry tears are located near the proximal descending aorta and the RA in these models are again assigned to 1 and 2, respectively.	Radium	4-6	VPS52 subunit of GARP complex	Homo sapiens	23-34
27775549-3	2016	We previously showed that expression of CYP26 in BM stromal cells maintains a retinoic acid-low (RA-low) microenvironment that prevents the differentiation of normal and malignant hematopoietic cells.	Radium	97-99	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	40-45
27775549-5	2016	CYP26-mediated inactivation of RA within the BM microenvironment prevented plasma cell differentiation and promoted a B cell-like, BTZ-resistant phenotype in human MM cells that were cocultured on BM stroma.	Radium	31-33	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	0-5
27991534-4	2016	Moreover, our results indicated that there was a significant reduction in the proportion of patients needing rescue medications in the TPO-RA groups compared with the control groups (RR: 0.50, 95% CI: 0.42-0.59, P = 2.0 x 10-15) and that the rates of any or severe adverse events were similar between the TPO-RA and control regimens (RR: 1.01, 95% CI: 0.92-1.10; RR: 0.74, 95% CI: 0.54-1.01; respectively).	Radium	139-141	thyroid peroxidase	Homo sapiens	135-138
27991534-4	2016	Moreover, our results indicated that there was a significant reduction in the proportion of patients needing rescue medications in the TPO-RA groups compared with the control groups (RR: 0.50, 95% CI: 0.42-0.59, P = 2.0 x 10-15) and that the rates of any or severe adverse events were similar between the TPO-RA and control regimens (RR: 1.01, 95% CI: 0.92-1.10; RR: 0.74, 95% CI: 0.54-1.01; respectively).	Radium	139-141	thyroid peroxidase	Homo sapiens	305-308
27809896-3	2016	To better understand the HLA-RA connection, we aimed to investigate if the enhanced capacity to present arginine-to-citrulline-converted peptides is unique for HLA-SE alleles.	Radium	29-31	major histocompatibility complex, class II, DR beta 1	Homo sapiens	160-163
27765925-7	2016	RA-GC status correlated with older age (P &lt; 0.001), differentiated histology (P = 0.001), intestinal or mixed type by Lauren classification (P &lt; 0.001), lymphovascular invasion (P = 0.026), and mutant-pattern of p53 (P &lt; 0.001).	Radium	0-2	tumor protein p53	Homo sapiens	218-221
27609837-4	2016	Consequently, HuR is crucial for the nuclear import of cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA to the nuclear retinoic acid receptor (RAR) and whose mobilization to the nucleus is mediated by a "classical-like" nuclear localization signal (NLS).	Radium	98-100	ELAV like RNA binding protein 1	Homo sapiens	14-17
27609837-4	2016	Consequently, HuR is crucial for the nuclear import of cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA to the nuclear retinoic acid receptor (RAR) and whose mobilization to the nucleus is mediated by a "classical-like" nuclear localization signal (NLS).	Radium	98-100	cellular retinoic acid binding protein 2	Homo sapiens	55-95
27609837-4	2016	Consequently, HuR is crucial for the nuclear import of cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA to the nuclear retinoic acid receptor (RAR) and whose mobilization to the nucleus is mediated by a "classical-like" nuclear localization signal (NLS).	Radium	98-100	retinoic acid receptor alpha	Homo sapiens	139-161
27609837-4	2016	Consequently, HuR is crucial for the nuclear import of cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA to the nuclear retinoic acid receptor (RAR) and whose mobilization to the nucleus is mediated by a "classical-like" nuclear localization signal (NLS).	Radium	98-100	retinoic acid receptor alpha	Homo sapiens	163-166
27459537-5	2016	PATIENT AND METHODS: We treated an insulin-dependent T2-WFS patient with the GLP-1-RA exenatide for 9 weeks.	Radium	83-85	insulin	Homo sapiens	35-42
27459537-5	2016	PATIENT AND METHODS: We treated an insulin-dependent T2-WFS patient with the GLP-1-RA exenatide for 9 weeks.	Radium	83-85	glucagon like peptide 1 receptor	Homo sapiens	77-82
27462069-7	2016	Immunoblotting showed that the superior/middle lateral RA had significantly higher adenosine A1 receptor (2.7+-1.7-fold; P&lt;0.01) and GIRK4 (1.7+-0.8-fold; P&lt;0.05) protein expression than lateral/posterior LA.	Radium	55-57	adenosine A1 receptor	Homo sapiens	83-104
27536890-12	2016	In vitro experiments revealed that the RA index was a potent regulator of acute insulin secretion where a high RA index (20ng ml-1 resistin, 5nmol l-1 g-adiponectin) significantly decreased insulin secretion whereas a low RA index (10ng ml-1 resistin, 10nmol l-1 g-adiponectin) significantly increased insulin secretion.	Radium	39-41	adiponectin, C1Q and collagen domain containing	Homo sapiens	153-164
27536890-12	2016	In vitro experiments revealed that the RA index was a potent regulator of acute insulin secretion where a high RA index (20ng ml-1 resistin, 5nmol l-1 g-adiponectin) significantly decreased insulin secretion whereas a low RA index (10ng ml-1 resistin, 10nmol l-1 g-adiponectin) significantly increased insulin secretion.	Radium	39-41	adiponectin, C1Q and collagen domain containing	Homo sapiens	265-276
27340132-7	2016	Interestingly, less toxic and aggregation incapable rat amylin (rA) showed a comparable inhibitory effect on proteasome activity and protein ubiquitination, decoupling amylin aggregation/ toxicity and amylin-induced protein stress.	Radium	64-66	islet amyloid polypeptide	Rattus norvegicus	56-62
27340132-7	2016	Interestingly, less toxic and aggregation incapable rat amylin (rA) showed a comparable inhibitory effect on proteasome activity and protein ubiquitination, decoupling amylin aggregation/ toxicity and amylin-induced protein stress.	Radium	64-66	islet amyloid polypeptide	Rattus norvegicus	168-174
27340132-7	2016	Interestingly, less toxic and aggregation incapable rat amylin (rA) showed a comparable inhibitory effect on proteasome activity and protein ubiquitination, decoupling amylin aggregation/ toxicity and amylin-induced protein stress.	Radium	64-66	islet amyloid polypeptide	Rattus norvegicus	168-174
27462069-7	2016	Immunoblotting showed that the superior/middle lateral RA had significantly higher adenosine A1 receptor (2.7+-1.7-fold; P&lt;0.01) and GIRK4 (1.7+-0.8-fold; P&lt;0.05) protein expression than lateral/posterior LA.	Radium	55-57	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	136-141
27462069-8	2016	CONCLUSIONS: This study revealed a 3-fold RA-to-LA adenosine A1 receptor protein expression gradient in the human heart, leading to significantly greater RA versus LA repolarization sensitivity in response to adenosine.	Radium	42-44	adenosine A1 receptor	Homo sapiens	51-72
27462069-8	2016	CONCLUSIONS: This study revealed a 3-fold RA-to-LA adenosine A1 receptor protein expression gradient in the human heart, leading to significantly greater RA versus LA repolarization sensitivity in response to adenosine.	Radium	154-156	adenosine A1 receptor	Homo sapiens	51-72
27447665-5	2016	9-cis-betac increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from betac in RAW264.7 macrophages.	Radium	75-77	cytochrome P450, family 26, subfamily b, polypeptide 1	Mus musculus	41-48
27446432-8	2016	However, 2 months after the administration of the final dose of Ra-223, PSA and BAP levels increased again, and bone pain deteriorated.	Radium	64-66	kallikrein related peptidase 3	Homo sapiens	72-75
27193470-7	2016	In conclusion, decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to RA inflammatory processes.	Radium	174-176	Fc receptor like 4	Homo sapiens	25-30
27193470-7	2016	In conclusion, decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to RA inflammatory processes.	Radium	174-176	Fc receptor like 2	Homo sapiens	61-66
27447665-5	2016	9-cis-betac increased the mRNA levels of CYP26B1, an enzyme that regulates RA cellular levels, indicating the formation of RA from betac in RAW264.7 macrophages.	Radium	123-125	cytochrome P450, family 26, subfamily b, polypeptide 1	Mus musculus	41-48
26549032-7	2016	In agreement, using three distinct assays that measure different aspects of the RasGTP/GDP cycle, we established that overexpression of RasGRP1 in T-ALLs results in a constitutively high GTP-loading rate of Ras, which is constantly counterbalanced by hydrolysis of RasGTP.	Radium	80-83	RAS guanyl releasing protein 1	Homo sapiens	136-143
26909716-1	2016	A 75-year-old man with castrate-resistant prostate cancer and increasing prostate-specific antigen (PSA) level developed severe bone marrow depression during Ra radionuclide therapy.	Radium	158-160	kallikrein related peptidase 3	Homo sapiens	73-104
27174050-5	2016	In the present study, we identified 9 Ru (II)-Arene Schiff-base (RAS) complexes able to induce p53-independent cytotoxicity and discuss structural features that are required for their p53-independent activity.	Radium	65-68	tumor protein p53	Homo sapiens	95-98
27174050-5	2016	In the present study, we identified 9 Ru (II)-Arene Schiff-base (RAS) complexes able to induce p53-independent cytotoxicity and discuss structural features that are required for their p53-independent activity.	Radium	65-68	tumor protein p53	Homo sapiens	184-187
27165430-7	2016	Identification of the regulatory subunits of KCa1.1 expressed by RA-FLS may therefore provide the opportunity for generating a selective target for RA treatment.	Radium	65-67	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	45-51
26983453-8	2016	When combining the discovery and validation cohorts, an intronic SNP in the Solute Carrier family 8 gene (SLC8A3) was found to be associated with ACPA-positive RA at a genome-wide level of significance RA [odds ratio (95% CI): 1.42 (1.25, 1.6), Pcombined = 3.19x10(-8)].	Radium	160-162	solute carrier family 8 member A3	Homo sapiens	106-112
26983453-8	2016	When combining the discovery and validation cohorts, an intronic SNP in the Solute Carrier family 8 gene (SLC8A3) was found to be associated with ACPA-positive RA at a genome-wide level of significance RA [odds ratio (95% CI): 1.42 (1.25, 1.6), Pcombined = 3.19x10(-8)].	Radium	160-162	proteinase 3	Homo sapiens	146-150
26837772-11	2016	Immunohistochemistry showed the protein levels of MMP1 in the Ra group were significantly increased when compared with the DMSO group (P &lt; 0.01) and the NS group (P &lt; 0.01).	Radium	62-64	interstitial collagenase	Oryctolagus cuniculus	50-54
27025400-10	2016	RA-NP were shown to be up to 83-fold more efficient than free RA and to enhance hEPC proliferation.	Radium	0-2	hepcidin antimicrobial peptide	Homo sapiens	80-84
26929410-5	2016	Osmotic swelling switches the kinetics of RA-MA currents to the slowly adapting type in both cultured DRG neurons and HEK293 cells heterologously expressing Piezo2.	Radium	42-44	piezo type mechanosensitive ion channel component 2	Homo sapiens	157-163
26974727-0	2016	Evidence-Based Guideline: ACR made 10 strong treatment recommendations for RA, but high-quality evidence was sparse.	Radium	75-77	acrosin	Homo sapiens	26-29
27081671-8	2016	Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands.	Radium	32-34	steroidogenic acute regulatory protein	Mus musculus	18-22
27081671-8	2016	Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands.	Radium	32-34	retinoic acid receptor, alpha	Mus musculus	192-214
27081671-8	2016	Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands.	Radium	32-34	retinoic acid receptor, alpha	Mus musculus	216-219
26769970-9	2016	In addition, GCNF also showed a regulatory gene pattern that is different from RA treatment during hES cell differentiation.	Radium	79-81	ribosome binding protein 1	Homo sapiens	99-102
26548884-8	2016	RESULTS: Groups Ap1 and Bp presented significantly lower Ra values compared with their respective uncoated groups A and B (P&lt;.001).	Radium	57-59	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-19
26714848-4	2016	Basal Ra is challenging to measure in insulin-dependent diabetes, where exogenous insulin required to maintain normoglycemia can raise peripheral insulin concentrations sufficiently to suppress basal Ra.	Radium	6-8	insulin	Homo sapiens	82-89
26714848-4	2016	Basal Ra is challenging to measure in insulin-dependent diabetes, where exogenous insulin required to maintain normoglycemia can raise peripheral insulin concentrations sufficiently to suppress basal Ra.	Radium	200-202	insulin	Homo sapiens	82-89
27160088-8	2016	PHS was shorter in the RA-LDP group (10.5 vs. 13 days; p = 0.02).	Radium	23-25	carboxypeptidase Q	Homo sapiens	26-29
26731668-7	2016	VARA supplementation increased total retinol in plasma, liver and lung, with a dose-by-dose accumulation in neonatal liver and lung, while transcripts for Lrat in liver, megalin in kidney, Cyp26A1/B1 in liver and lung, respectively, and Stra6 in lung, were all increased, suggesting pathways of VA uptake, storage and RA oxidation were each augmented after VARA.	Radium	2-4	signaling receptor and transporter of retinol STRA6	Homo sapiens	237-242
26370400-9	2016	CONCLUSION: The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA.	Radium	199-201	AGBL carboxypeptidase 2	Homo sapiens	49-53
26815200-4	2016	We further demonstrate that such EndMT is initiated by recruitment of aberrantly phosphorylated DNMT1 to the RASAL1 CpG island promoter by HDAC2, causing aberrant promoter methylation and transcriptional suppression, ultimately leading to increased Ras-GTP activity and activation of common EndMT regulators Twist and Snail.	Radium	249-252	DNA methyltransferase 1	Homo sapiens	96-101
26815200-4	2016	We further demonstrate that such EndMT is initiated by recruitment of aberrantly phosphorylated DNMT1 to the RASAL1 CpG island promoter by HDAC2, causing aberrant promoter methylation and transcriptional suppression, ultimately leading to increased Ras-GTP activity and activation of common EndMT regulators Twist and Snail.	Radium	249-252	RAS protein activator like 1	Homo sapiens	109-115
26815200-4	2016	We further demonstrate that such EndMT is initiated by recruitment of aberrantly phosphorylated DNMT1 to the RASAL1 CpG island promoter by HDAC2, causing aberrant promoter methylation and transcriptional suppression, ultimately leading to increased Ras-GTP activity and activation of common EndMT regulators Twist and Snail.	Radium	249-252	histone deacetylase 2	Homo sapiens	139-144
26815200-4	2016	We further demonstrate that such EndMT is initiated by recruitment of aberrantly phosphorylated DNMT1 to the RASAL1 CpG island promoter by HDAC2, causing aberrant promoter methylation and transcriptional suppression, ultimately leading to increased Ras-GTP activity and activation of common EndMT regulators Twist and Snail.	Radium	249-252	snail family transcriptional repressor 1	Homo sapiens	318-323
26765066-12	2016	More mechanistic studies are needed to further explain the association between PTH and Ca concentration and RA.	Radium	108-110	parathyroid hormone	Homo sapiens	79-82
26742834-9	2016	These findings suggest that caspase-1 is a potential therapeutic target for RA treatment.	Radium	76-78	caspase 1	Mus musculus	28-37
26150526-10	2015	Furthermore, elevated c-Src stimulates Ras GTP-loading and activates Raf and MEK kinases.	Radium	39-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-27
25731768-8	2015	Compared with patients without RA, the adjusted model demonstrated that patients with diabetes and RA were 28% less likely to have diabetic retinopathy and 4% more likely to receive an eye exam [ARR 0.72 (95% CI 0.67, 0.77), ARR 1.04 (95% CI 1.02, 1.06)].	Radium	99-101	arrestin beta 1	Homo sapiens	225-230
26715450-5	2015	METHODS: We have compared the functional Multidrug Activity Factors (MAF) of the MDR1 and MRP1 transporters of Peripheral Blood Leukocytes of 59 Rheumatoid Arthritis patients with various response rate to MTX-therapy (MTX-responder, MTX-resistant and MTX-intolerant RA-groups) and 47 non-RA controls in six different leukocyte subpopulations (neutrophil leukocytes, monocytes, lymphocytes, CD4+, CD8+ and CD19+ cells).	Radium	266-268	ATP binding cassette subfamily B member 1	Homo sapiens	81-85
26715450-5	2015	METHODS: We have compared the functional Multidrug Activity Factors (MAF) of the MDR1 and MRP1 transporters of Peripheral Blood Leukocytes of 59 Rheumatoid Arthritis patients with various response rate to MTX-therapy (MTX-responder, MTX-resistant and MTX-intolerant RA-groups) and 47 non-RA controls in six different leukocyte subpopulations (neutrophil leukocytes, monocytes, lymphocytes, CD4+, CD8+ and CD19+ cells).	Radium	266-268	ATP binding cassette subfamily C member 1	Homo sapiens	90-94
26553605-0	2015	Rheumatoid arthritis: Novel NFkappaB inhibitor associated with RA severity.	Radium	63-65	nuclear factor kappa B subunit 1	Homo sapiens	28-36
26248207-6	2015	RA treatment expanded the pronephric proximal domain in normal embryos as in taz morphants, an effect that was further enhanced upon exposure of taz morphants to RA.	Radium	0-2	tafazzin, phospholipid-lysophospholipid transacylase	Danio rerio	77-80
26248207-6	2015	RA treatment expanded the pronephric proximal domain in normal embryos as in taz morphants, an effect that was further enhanced upon exposure of taz morphants to RA.	Radium	0-2	tafazzin, phospholipid-lysophospholipid transacylase	Danio rerio	145-148
26248207-6	2015	RA treatment expanded the pronephric proximal domain in normal embryos as in taz morphants, an effect that was further enhanced upon exposure of taz morphants to RA.	Radium	162-164	tafazzin, phospholipid-lysophospholipid transacylase	Danio rerio	145-148
26248207-9	2015	The present findings show that Taz is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating RA signaling in the pronephric progenitor field in the intermediate mesoderm.	Radium	176-178	tafazzin, phospholipid-lysophospholipid transacylase	Danio rerio	31-34
26379840-9	2015	The IC50 for RA in RA-PEG-SH-AuNPs after 12 and 24 h were 3 and 1 muM, respectively.	Radium	13-15	latexin	Homo sapiens	66-69
26009294-0	2015	Rheumatoid arthritis: Clues to the HLA-RA connection from T-cell crossreactivity to vinculin and microorganisms.	Radium	39-41	vinculin	Homo sapiens	84-92
25406356-8	2015	The levels of phospho-STAT3 in resting PB T cells and monocytes were significantly higher in patients with RA than in healthy volunteers.	Radium	107-109	signal transducer and activator of transcription 3	Homo sapiens	22-27
26080448-3	2015	Functional studies revealed that HSP70 could directly regulate retinoid acid (RA)-induced retinoid acid receptor beta2 (RARbeta2) gene transcription through its binding to chromatin, with R469me1 being essential in this process.	Radium	78-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	33-38
26080448-3	2015	Functional studies revealed that HSP70 could directly regulate retinoid acid (RA)-induced retinoid acid receptor beta2 (RARbeta2) gene transcription through its binding to chromatin, with R469me1 being essential in this process.	Radium	78-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	113-118
25753732-10	2015	Using Cdx1 as an entry point, we identified the retinoid acid (RA) and canonical Wnt pathways as downstream targets of Gpr161.	Radium	63-65	caudal type homeobox 1	Mus musculus	6-10
25753732-10	2015	Using Cdx1 as an entry point, we identified the retinoid acid (RA) and canonical Wnt pathways as downstream targets of Gpr161.	Radium	63-65	G protein-coupled receptor 161	Mus musculus	119-125
25753732-12	2015	Intraperitoneal RA injection restores expression of canonical Wnt markers and rescues Gpr161(vl/vl) NTDs.	Radium	16-18	G protein-coupled receptor 161	Mus musculus	86-92
26191192-7	2015	Compared with the RA group, the OIR mice exhibited over-expression in VEGF and HIF-1alpha mRNA and protein.	Radium	18-20	vascular endothelial growth factor A	Mus musculus	70-74
25897113-6	2015	Our data offer an unprecedentedly detailed view on the action of RA in triggering pluripotent cell differentiation and demonstrate that RAR/RXR action is mediated via two different sets of regulatory regions tightly associated with cell differentiation status.	Radium	65-67	retinoic acid receptor, alpha	Mus musculus	136-139
26191192-7	2015	Compared with the RA group, the OIR mice exhibited over-expression in VEGF and HIF-1alpha mRNA and protein.	Radium	18-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	79-89
25617125-12	2015	Taken together, our findings suggest that AIMP1 exacerbates RA by promoting inflammation and osteoclastogenesis and that atliximab could be developed as a therapeutic antibody to target inflammatory diseases, including RA.	Radium	60-62	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	Mus musculus	42-47
25583377-7	2015	RA-PAH patients had an older median age of onset (64.0 vs 53.7 years) and lower baseline mean pulmonary arterial pressure (mPAP) (41 vs 50 mm Hg, P = 0.02).	Radium	0-2	phospholipid phosphatase 1	Mus musculus	123-127
25054647-5	2015	PEDF protein was increased in hyperoxic lungs compared with RA-exposed lungs (P &lt; 0.05).	Radium	60-62	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	0-4
25832527-1	2015	OBJECTIVE: To detect the expression of RA SAL2 in patients with hepatocellular carcinoma (HCC), and to investigate the association of RASAL2 expression with pathological characteristics and prognosis.	Radium	39-41	spalt like transcription factor 2	Homo sapiens	42-46
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P &lt; 0.05).	Radium	32-35	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	164-169
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P &lt; 0.05).	Radium	32-35	KRAS proto-oncogene, GTPase	Homo sapiens	171-175
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P &lt; 0.05).	Radium	32-35	mitogen-activated protein kinase 3	Homo sapiens	183-189
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P &lt; 0.05).	Radium	32-35	microRNA 21	Homo sapiens	268-274
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P &lt; 0.05).	Radium	32-35	RAS p21 protein activator 1	Homo sapiens	58-63
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P &lt; 0.05).	Radium	32-35	RAS p21 protein activator 1	Homo sapiens	58-63
26090479-4	2015	RESULTS: Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P &lt; 0.001).	Radium	47-49	AGBL carboxypeptidase 2	Homo sapiens	21-25
26233912-5	2015	In the immune system, the ALDH1A and CYP26 enzymes appear to modulate RA concentrations.	Radium	70-72	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	37-42
25447206-4	2015	We have determined that miR-134 is induced during RA-induced differentiation of NT2/D1 cells and the overexpression of miR-134 represses the expression of FOXM1 protein but not FOXM1 mRNA.	Radium	50-52	microRNA 134	Homo sapiens	24-31
25447206-4	2015	We have determined that miR-134 is induced during RA-induced differentiation of NT2/D1 cells and the overexpression of miR-134 represses the expression of FOXM1 protein but not FOXM1 mRNA.	Radium	50-52	forkhead box M1	Homo sapiens	155-160
25351936-11	2015	CONCLUSIONS: From this initial study, we can conclude that PTPN22-rs2476601 and STAT4-rs7574865 polymorphisms are clearly associated with the risk of RA in the Western Algerian population.	Radium	150-152	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	59-65
25351936-11	2015	CONCLUSIONS: From this initial study, we can conclude that PTPN22-rs2476601 and STAT4-rs7574865 polymorphisms are clearly associated with the risk of RA in the Western Algerian population.	Radium	150-152	signal transducer and activator of transcription 4	Homo sapiens	80-85
24838830-6	2014	The chirodiastaltic energies amount to a total of 1.77 kJ mol(-1) for the Ra:Ra versus Ra:Sa (PH2-PH2 )2 dimers, 0.81 kJ mol(-1) for the RSa:RSa versus RSa:SRa (PH2-PHF)2 dimers, and 2.93 kJ mol(-1) for the RRa:RRa versus RRa:SSa (PH2-PHF)2 dimers.	Radium	74-76	steroid receptor RNA activator 1	Homo sapiens	156-159
26246959-9	2015	Crystallin alpha B (hypertrophy inhibitor) was upregulated in both the RV (+2.2) and RA (+2.6).	Radium	85-87	crystallin alpha B	Canis lupus familiaris	0-18
26067715-9	2015	CONCLUSIONS: These findings suggest, for the first time in humans, that higher serum uric acid levels are associated significantly with Ra in subjects with Cin &gt; 60 ml/min/1.73m(2).	Radium	136-138	pyridoxal phosphatase	Homo sapiens	156-159
25118313-8	2015	Patients with RA expressed increased levels of phosphorylated or active RelA (p65) compared with controls.	Radium	14-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	72-76
25118313-8	2015	Patients with RA expressed increased levels of phosphorylated or active RelA (p65) compared with controls.	Radium	14-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	78-81
25624860-11	2014	196G/A of BDNF correlated with the parameters GDx and RA (p = 0.03; p = 0.002, respectively), while 190G/C of HSP70-1 correlated with c/d and RA (p = 0.014, p = 0.024, respectively).	Radium	54-56	brain derived neurotrophic factor	Homo sapiens	10-14
25624860-11	2014	196G/A of BDNF correlated with the parameters GDx and RA (p = 0.03; p = 0.002, respectively), while 190G/C of HSP70-1 correlated with c/d and RA (p = 0.014, p = 0.024, respectively).	Radium	142-144	heat shock protein family A (Hsp70) member 1A	Homo sapiens	110-117
25477235-4	2014	We found that atRA inhibited MEPM-cell proliferation by downregulating TGF-beta/Smad signaling and that TGF-beta3 treatment was able to antagonize RA signaling.	Radium	16-18	transforming growth factor, beta 1	Mus musculus	71-79
25920201-3	2014	Compared with the inhibition effect of RA decoctions on CYP450 isoforms, their co-decoctions of RA and RPA with different proportions can decrease RA" inhibition on CYP3A, CYP2D, CYP2C and CYP1A2, but can not reduce RA" effect on CYP2E1.	Radium	96-98	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	189-195
25920201-3	2014	Compared with the inhibition effect of RA decoctions on CYP450 isoforms, their co-decoctions of RA and RPA with different proportions can decrease RA" inhibition on CYP3A, CYP2D, CYP2C and CYP1A2, but can not reduce RA" effect on CYP2E1.	Radium	96-98	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	230-236
25059841-10	2015	RA demonstrated significant upregulation of podoplanin at the invasive front (P &lt; 0.05), whereas upregulation of beta-catenin and CD44v6 and downregulation of E-cadherin at this site were not statistically significant (P &gt; 0.05).	Radium	0-2	podoplanin	Homo sapiens	44-54
25446507-7	2015	Most RA (n = 12/15; 80%) exhibited a bimolecular spatial expression pattern, the most common being RANK-positive/OPG-positive (n = 8/15; 53.3%).	Radium	5-7	TNF receptor superfamily member 11a	Homo sapiens	99-103
25446507-7	2015	Most RA (n = 12/15; 80%) exhibited a bimolecular spatial expression pattern, the most common being RANK-positive/OPG-positive (n = 8/15; 53.3%).	Radium	5-7	TNF receptor superfamily member 11b	Homo sapiens	113-116
24838830-6	2014	The chirodiastaltic energies amount to a total of 1.77 kJ mol(-1) for the Ra:Ra versus Ra:Sa (PH2-PH2 )2 dimers, 0.81 kJ mol(-1) for the RSa:RSa versus RSa:SRa (PH2-PHF)2 dimers, and 2.93 kJ mol(-1) for the RRa:RRa versus RRa:SSa (PH2-PHF)2 dimers.	Radium	77-79	steroid receptor RNA activator 1	Homo sapiens	156-159
24777778-1	2014	Several studies have examined the effects of tumor necrosis factor receptor (TNFR) 1 +38 A/G and TNFR2 196 M/R polymorphisms on susceptibility to RA and have reported conflicting results.	Radium	146-148	TNF receptor superfamily member 1A	Homo sapiens	45-75
25382096-12	2014	Due to the differences in pharmacokinetics, efficacy, rates of adverse effects, and administration requirements within the GLP-1 RA class, each agent should be evaluated independently.	Radium	129-131	glucagon like peptide 1 receptor	Homo sapiens	123-128
24777778-1	2014	Several studies have examined the effects of tumor necrosis factor receptor (TNFR) 1 +38 A/G and TNFR2 196 M/R polymorphisms on susceptibility to RA and have reported conflicting results.	Radium	146-148	TNF receptor superfamily member 1A	Homo sapiens	77-81
24777778-1	2014	Several studies have examined the effects of tumor necrosis factor receptor (TNFR) 1 +38 A/G and TNFR2 196 M/R polymorphisms on susceptibility to RA and have reported conflicting results.	Radium	146-148	TNF receptor superfamily member 1B	Homo sapiens	97-102
24777778-9	2014	Our meta-analysis demonstrated that the functional TNFR2 196 M/R polymorphism is associated with susceptibility to RA in the European population.	Radium	115-117	TNF receptor superfamily member 1B	Homo sapiens	51-56
24831057-3	2014	This process in the gums appears to be independent of smoking, the main environmental risk factor for ACPA-positive RA.	Radium	116-118	proteinase 3	Homo sapiens	102-106
25024169-5	2014	All constructs were studied in radioligand binding and/or functional IP turnover assays, providing evidence for an intracellular binding site for CCR2-RA-[R], JNJ-27141491, and SD-24.	Radium	151-153	C-C motif chemokine receptor 2	Homo sapiens	146-150
25314524-8	2014	The secondary instability is temporally periodic for Pr=0.1 but quasiperiodic for Pr=0.025 for moderate values of Q. Convective patterns for higher values of Ra consist of periodic, quasiperiodic, and chaotic wavy rolls above the onset of the secondary instability for eta=1.	Radium	158-160	secreted phosphoprotein 1	Homo sapiens	269-274
25192011-3	2014	RA-36, the 31-meric DNA aptamer, consists of two thrombin binding pharmacophores joined with the thymine linker.	Radium	0-2	coagulation factor II	Mus musculus	49-57
25192011-4	2014	It has been shown earlier that RA-36 directly inhibits thrombin in the reaction of fibrinogen hydrolysis, and also it inhibits plasma and blood coagulation.	Radium	31-33	coagulation factor II	Mus musculus	55-63
25124193-8	2014	Furthermore, Wnt5a overexpression positively correlated with levels of Camk2d and Ror2 in C2C12 cells after RA exposure.	Radium	108-110	wingless-type MMTV integration site family, member 5A	Mus musculus	13-18
25124193-8	2014	Furthermore, Wnt5a overexpression positively correlated with levels of Camk2d and Ror2 in C2C12 cells after RA exposure.	Radium	108-110	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	71-77
25124193-8	2014	Furthermore, Wnt5a overexpression positively correlated with levels of Camk2d and Ror2 in C2C12 cells after RA exposure.	Radium	108-110	receptor tyrosine kinase-like orphan receptor 2	Mus musculus	82-86
25115332-14	2014	CONCLUSION: The present study suggests that a selective CB(2) agonist could be a new therapy for RA that inhibits production of inflammatory mediators from FLS, and osteoclastogenesis.	Radium	97-99	cannabinoid receptor 2 (macrophage)	Mus musculus	56-61
24824214-10	2014	In addition, miR-15b was upregulated in AF within RA only, and miR-106a, -18a, -18b, -19a, -19b, -23a, -25, -30a, -363, -486-5p, -590-5p, and -93 were upregulated in AF within LA only.	Radium	50-52	microRNA 15b	Homo sapiens	13-20
24971534-9	2014	ESE-1 interacted with the EBS element in CR2 and enrichment of CR2 significantly increased upon RA-mediated differentiation of NCCIT cells, suggesting that this binding is likely to be involved in ESE-1-mediated repression of OCT4 promoter activity upon differentiation.	Radium	96-98	E74 like ETS transcription factor 3	Homo sapiens	0-5
24971534-9	2014	ESE-1 interacted with the EBS element in CR2 and enrichment of CR2 significantly increased upon RA-mediated differentiation of NCCIT cells, suggesting that this binding is likely to be involved in ESE-1-mediated repression of OCT4 promoter activity upon differentiation.	Radium	96-98	E74 like ETS transcription factor 3	Homo sapiens	197-202
24971534-9	2014	ESE-1 interacted with the EBS element in CR2 and enrichment of CR2 significantly increased upon RA-mediated differentiation of NCCIT cells, suggesting that this binding is likely to be involved in ESE-1-mediated repression of OCT4 promoter activity upon differentiation.	Radium	96-98	POU class 5 homeobox 1	Homo sapiens	226-230
24500066-3	2014	This study aimed to evaluate the effect of TPO-RA treatment on platelet function and on the procoagulant state in ITP patients before (ITP-bR) and after responding (ITP-aR) to treatment.	Radium	47-49	thyroid peroxidase	Homo sapiens	43-46
24725224-4	2014	We aimed to describe the subset of patients in whom transient Tpo-RA therapy may induce a durable response.	Radium	66-68	thyroid peroxidase	Homo sapiens	62-65
24531877-7	2014	Moreover, decreased expression of RASAL1 in MKN-28 cells resulted in increased expression of RAS-GTP and p-ERK1/2.	Radium	34-37	mitogen-activated protein kinase 3	Homo sapiens	107-113
24531877-9	2014	The increased expression of RASAL1 in BGC-823 cells caused declined expression of RAS-GTP and p-ERK1/2, as well as promoted apoptosis and restrained cell proliferation, invasion and migration.	Radium	28-31	mitogen-activated protein kinase 3	Homo sapiens	96-102
24790153-4	2014	Arginase-1 (Arg-1) was found promote suppression because 1) ATRA was a potent inducer of Arg-1 protein and activity, 2) the Arg-1 inhibitor N(w)-hydroxy nor-l-arginine partially reversed suppression, and 3) the suppressive function of RA-DCs was partially compromised using OT-II T cells from GCN2(-/-) mice, which are insensitive to Arg-1.	Radium	62-64	arginase, liver	Mus musculus	0-10
24790153-4	2014	Arginase-1 (Arg-1) was found promote suppression because 1) ATRA was a potent inducer of Arg-1 protein and activity, 2) the Arg-1 inhibitor N(w)-hydroxy nor-l-arginine partially reversed suppression, and 3) the suppressive function of RA-DCs was partially compromised using OT-II T cells from GCN2(-/-) mice, which are insensitive to Arg-1.	Radium	62-64	arginase, liver	Mus musculus	12-17
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	0-21
24790153-4	2014	Arginase-1 (Arg-1) was found promote suppression because 1) ATRA was a potent inducer of Arg-1 protein and activity, 2) the Arg-1 inhibitor N(w)-hydroxy nor-l-arginine partially reversed suppression, and 3) the suppressive function of RA-DCs was partially compromised using OT-II T cells from GCN2(-/-) mice, which are insensitive to Arg-1.	Radium	62-64	arginase, liver	Mus musculus	89-94
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	23-27
24790153-4	2014	Arginase-1 (Arg-1) was found promote suppression because 1) ATRA was a potent inducer of Arg-1 protein and activity, 2) the Arg-1 inhibitor N(w)-hydroxy nor-l-arginine partially reversed suppression, and 3) the suppressive function of RA-DCs was partially compromised using OT-II T cells from GCN2(-/-) mice, which are insensitive to Arg-1.	Radium	62-64	arginase, liver	Mus musculus	89-94
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	interferon gamma	Mus musculus	150-159
24790153-4	2014	Arginase-1 (Arg-1) was found promote suppression because 1) ATRA was a potent inducer of Arg-1 protein and activity, 2) the Arg-1 inhibitor N(w)-hydroxy nor-l-arginine partially reversed suppression, and 3) the suppressive function of RA-DCs was partially compromised using OT-II T cells from GCN2(-/-) mice, which are insensitive to Arg-1.	Radium	62-64	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	293-297
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	168-172
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	168-172
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	168-172
24790153-4	2014	Arginase-1 (Arg-1) was found promote suppression because 1) ATRA was a potent inducer of Arg-1 protein and activity, 2) the Arg-1 inhibitor N(w)-hydroxy nor-l-arginine partially reversed suppression, and 3) the suppressive function of RA-DCs was partially compromised using OT-II T cells from GCN2(-/-) mice, which are insensitive to Arg-1.	Radium	62-64	arginase, liver	Mus musculus	89-94
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	arginase, liver	Mus musculus	402-407
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	89-91	nitric oxide synthase 2, inducible	Mus musculus	0-21
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	89-91	nitric oxide synthase 2, inducible	Mus musculus	23-27
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	89-91	interferon gamma	Mus musculus	150-159
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	89-91	arginase, liver	Mus musculus	402-407
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	0-21
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	23-27
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	interferon gamma	Mus musculus	150-159
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	168-172
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	168-172
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	nitric oxide synthase 2, inducible	Mus musculus	168-172
24790153-5	2014	Inducible NO synthase (iNOS), however, was found to be a more significant contributor to RA-DC function because 1) ATRA potentiated the expression of IFN-gamma-induced iNOS, 2) suppressive function in RA-DCs was blocked by the iNOS inhibitor N(G)-monomethyl-l-arginine, monoacetate salt, and 3) RA-DCs derived from iNOS(-/-) mice exhibited near complete loss of tolerogenic function, despite sustained Arg-1 activity.	Radium	117-119	arginase, liver	Mus musculus	402-407
24687854-2	2014	We show that HuR directly interacts with cellular retinoic acid-binding protein 2 (CRABP2), a protein known to transport RA from the cytosol to the nuclear retinoic acid receptor (RAR).	Radium	84-86	ELAV like RNA binding protein 1	Homo sapiens	13-16
24687854-2	2014	We show that HuR directly interacts with cellular retinoic acid-binding protein 2 (CRABP2), a protein known to transport RA from the cytosol to the nuclear retinoic acid receptor (RAR).	Radium	84-86	cellular retinoic acid binding protein 2	Homo sapiens	41-81
24687854-2	2014	We show that HuR directly interacts with cellular retinoic acid-binding protein 2 (CRABP2), a protein known to transport RA from the cytosol to the nuclear retinoic acid receptor (RAR).	Radium	84-86	retinoic acid receptor alpha	Homo sapiens	156-178
24687854-2	2014	We show that HuR directly interacts with cellular retinoic acid-binding protein 2 (CRABP2), a protein known to transport RA from the cytosol to the nuclear retinoic acid receptor (RAR).	Radium	84-86	retinoic acid receptor alpha	Homo sapiens	180-183
24824320-9	2014	Our study showed that treatment with multiple doses of RA had an inductive effect on rat CYP1A2 and an inhibitory effect on rat CYP3A4 enzyme activity.	Radium	55-57	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	89-95
24824320-11	2014	CONCLUSIONS: Caution is needed when RA is co-administration with some CYP1A2 or CYP3A4 substrates in clinic, because it may result in treatment failure and herb-drug interactions.	Radium	36-38	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	70-76
24811196-9	2014	CONCLUSIONS: FYB users incurred the highest levels of total costs, while their non-DMARD related costs remained similar to non-biologic users, possibly reflecting better RA control.	Radium	170-172	FYN binding protein 1	Homo sapiens	13-16
24492385-0	2014	Rheumatoid arthritis: Are FcRL4+ B cells the next target for RA biologic therapy?	Radium	61-63	Fc receptor like 4	Homo sapiens	26-31
24849446-5	2014	RESULTS: P60 had the lowest Ra (0.125-+0.030 microm) followed by Z250 and Spectrum.	Radium	28-30	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	9-12
24257117-6	2014	Our results point at CREB as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent.	Radium	120-122	SRY-box transcription factor 3	Homo sapiens	136-140
24289988-0	2014	PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2.	Radium	14-16	PRAME nuclear receptor transcriptional regulator	Homo sapiens	61-66
24289988-0	2014	PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2.	Radium	14-16	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	71-75
24265455-5	2014	Targeted silencing of endogenous RARalpha and RXRalpha, with small interfering RNAs, resulted in decreases in 9-cis RA-stimulated StAR and progesterone levels.	Radium	33-35	steroidogenic acute regulatory protein	Mus musculus	130-134
24749345-7	2014	The highest expression level of IGF-I in RA group were much higher from 4 d to 7 d (alveolar development period) but significantly lower in 14 d. There was a positive correlation between IGF-I and alveolar development.	Radium	41-43	insulin-like growth factor 1	Rattus norvegicus	32-37
24749345-7	2014	The highest expression level of IGF-I in RA group were much higher from 4 d to 7 d (alveolar development period) but significantly lower in 14 d. There was a positive correlation between IGF-I and alveolar development.	Radium	41-43	insulin-like growth factor 1	Rattus norvegicus	187-192
24749345-8	2014	In comparison with RA group, the expression levels of IGF-I in O2 group were significantly lower in 4 d and 7 d but were significantly higher in 14 d (P &lt; 0.05); In comparison with O2 group, the expression levels of IGF-I in O2 group significantly increased in 4 d and 7 d but significantly reduced in 14 d (P &lt; 0.05).	Radium	19-21	insulin-like growth factor 1	Rattus norvegicus	54-59
24528488-1	2014	BACKGROUND: We have previously identified BRINP (BMP/RA-inducible neural-specific protein-1, 2, 3) family genes that possess the ability to suppress cell cycle progression in neural stem cells.	Radium	53-55	bone morphogenic protein/retinoic acid inducible neural specific 1	Mus musculus	42-47
24394593-8	2014	The introduction of a point mutation in TDG, which neither affects overall protein structure nor BER activity, leads to a significant loss in ternary complex stability, resulting in the deregulation of RA targets involved in cellular networks associated with DNA replication, recombination and repair.	Radium	202-204	thymine DNA glycosylase	Homo sapiens	40-43
25522241-13	2014	Studying retinoid acid (RA) response of SH-SY5Y cell line, a model of human metastatic neuroblastoma, we found that HOXD-AS1 is a subject to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation.	Radium	24-26	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	116-124
23882111-1	2014	RA is characterized by chronic inflammation in the musculoskeletal system, in which TNF-alpha is the key cytokine trigger.	Radium	0-2	tumor necrosis factor	Homo sapiens	84-93
24422478-9	2014	This study also shows that an oxidant not only inhibits the catalytic action of Cdc25 on Ras-SNO but also fails to enhance Ras-SNO GNE.	Radium	89-92	cell division cycle 25C	Homo sapiens	80-85
25522241-13	2014	Studying retinoid acid (RA) response of SH-SY5Y cell line, a model of human metastatic neuroblastoma, we found that HOXD-AS1 is a subject to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation.	Radium	24-26	AKT serine/threonine kinase 1	Homo sapiens	186-189
25522241-13	2014	Studying retinoid acid (RA) response of SH-SY5Y cell line, a model of human metastatic neuroblastoma, we found that HOXD-AS1 is a subject to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation.	Radium	235-237	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	116-124
25217584-2	2014	We have studied the effect of activation of the retinoic A receptor, at the RARE-promoter chromatin of CASP9 and CYP26A1 genes, 15 and 45 min following RA exposure, and we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific demethylase, LSD1 and by the JMJ-domain containing demethylase, D2A.	Radium	76-78	caspase 9	Homo sapiens	103-108
25217584-2	2014	We have studied the effect of activation of the retinoic A receptor, at the RARE-promoter chromatin of CASP9 and CYP26A1 genes, 15 and 45 min following RA exposure, and we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific demethylase, LSD1 and by the JMJ-domain containing demethylase, D2A.	Radium	76-78	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	113-120
25505515-3	2013	A temporal Cx43 downregulation was confirmed in both cell lines during RA-induced neuronal differentiation using RT-PCR (P &lt; 0.05) preceding an increase in neuronal doublecortin protein.	Radium	71-73	gap junction protein alpha 1	Homo sapiens	11-15
24373564-3	2013	CASE PRESENTATION: We present the case of a 40-year-old woman, with a confirmed erosive and seropositive RA, successfully treated by TNFalpha blocker (etanercept) for seven years, and who developed a severe neurosarcoidosis.	Radium	105-107	tumor necrosis factor	Homo sapiens	133-141
23901134-1	2013	OBJECTIVE: The MHC exerts the greatest contribution to RA susceptibility, where certain HLA-DRB1 alleles confer the greatest risk.	Radium	55-57	major histocompatibility complex, class I, C	Homo sapiens	15-18
23800300-12	2013	We observed an association of decreased RA value (rim area) with the -82 A/G MMP12 (anova, p &lt; 0.001).	Radium	40-42	matrix metallopeptidase 12	Homo sapiens	77-82
23800300-13	2013	Normal RA value was observed in patients with POAG group connected with the 372 T/C TIMP1 (anova, p &lt; 0.05) and the -511 C/T IL-1beta (anova, p &lt; 0.05) genes polymorphisms occurrence.	Radium	7-9	TIMP metallopeptidase inhibitor 1	Homo sapiens	84-89
23800300-13	2013	Normal RA value was observed in patients with POAG group connected with the 372 T/C TIMP1 (anova, p &lt; 0.05) and the -511 C/T IL-1beta (anova, p &lt; 0.05) genes polymorphisms occurrence.	Radium	7-9	interleukin 1 beta	Homo sapiens	128-136
23901134-1	2013	OBJECTIVE: The MHC exerts the greatest contribution to RA susceptibility, where certain HLA-DRB1 alleles confer the greatest risk.	Radium	55-57	major histocompatibility complex, class II, DR beta 1	Homo sapiens	88-96
23526782-6	2013	In agreement with flow cytometry analysis, increased cell proliferation was observed after RA induction in Rnf10 knockdown cells as determined by a BrdU incorporation assay.	Radium	91-93	ring finger protein 10	Homo sapiens	107-112
24065740-5	2013	We further demonstrated that H3.3 actively marks enhancers and determines the transcriptional potential of retinoid acid (RA)-regulated genes via creating an open chromatin signature that enables the binding of RAR/RXR.	Radium	122-124	retinoid X receptor alpha	Homo sapiens	215-218
23926185-11	2013	These data indicate for the first time that C3 may be a primary factor to activate the renal RA systems to induce hypertension.	Radium	93-95	complement component 3	Mus musculus	44-46
23891710-3	2013	The serum [EPO] response was blunted in all RA groups compared to IA but the resulting reticulocyte response was similar in all experimental groups.	Radium	44-46	erythropoietin	Mus musculus	11-14
24023268-13	2013	Chromatin immunoprecipitation showed RA-dependent binding of RARalpha to the RARE2-containing promoter region in vivo.	Radium	37-39	retinoic acid receptor alpha	Homo sapiens	61-69
23783432-7	2013	RA treatment for 12 h activated Math1, although RA alone had very limited effects on mucus-like cell differentiation.	Radium	0-2	atonal bHLH transcription factor 1	Mus musculus	32-37
23335000-9	2013	ATXN2 absence by itself was insufficient to significantly change Grb2-dependent signaling for endogenous Ras levels, Ras-GTP levels, and kinetics as well as MEK1 phosphorylation, suggesting that other factors compensate for proliferation control.	Radium	105-108	growth factor receptor bound protein 2	Mus musculus	65-69
23967305-7	2013	The integrated RA-PH structural unit in Grb7-10-14 is also found in a second adaptor family that includes Rap1-interacting adaptor molecule (RIAM) and lamellipodin, proteins involved in actin-cytoskeleton rearrangement.	Radium	15-17	amyloid beta precursor protein binding family B member 1 interacting protein	Homo sapiens	106-139
23981290-17	2013	Hepatic RA mediated through RXRalpha and its partners regulates lipid homeostasis.	Radium	8-10	retinoid X receptor alpha	Mus musculus	28-36
23967305-7	2013	The integrated RA-PH structural unit in Grb7-10-14 is also found in a second adaptor family that includes Rap1-interacting adaptor molecule (RIAM) and lamellipodin, proteins involved in actin-cytoskeleton rearrangement.	Radium	15-17	amyloid beta precursor protein binding family B member 1 interacting protein	Homo sapiens	141-145
23967305-7	2013	The integrated RA-PH structural unit in Grb7-10-14 is also found in a second adaptor family that includes Rap1-interacting adaptor molecule (RIAM) and lamellipodin, proteins involved in actin-cytoskeleton rearrangement.	Radium	15-17	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	151-163
23967305-8	2013	The structure of Grb14 RA-PH in complex with H-Ras represents the first detailed molecular characterization of tandem RA-PH domains bound to a small GTPase and provides insights into the molecular basis for specificity.	Radium	23-25	growth factor receptor bound protein 14	Homo sapiens	17-22
23967305-8	2013	The structure of Grb14 RA-PH in complex with H-Ras represents the first detailed molecular characterization of tandem RA-PH domains bound to a small GTPase and provides insights into the molecular basis for specificity.	Radium	23-25	HRas proto-oncogene, GTPase	Homo sapiens	45-50
23967305-8	2013	The structure of Grb14 RA-PH in complex with H-Ras represents the first detailed molecular characterization of tandem RA-PH domains bound to a small GTPase and provides insights into the molecular basis for specificity.	Radium	118-120	growth factor receptor bound protein 14	Homo sapiens	17-22
23967305-8	2013	The structure of Grb14 RA-PH in complex with H-Ras represents the first detailed molecular characterization of tandem RA-PH domains bound to a small GTPase and provides insights into the molecular basis for specificity.	Radium	118-120	HRas proto-oncogene, GTPase	Homo sapiens	45-50
23587914-10	2013	The results of our meta-analysis suggest that IL-18 rs360722 SNP is only associated with RA susceptibility.	Radium	89-91	interleukin 18	Homo sapiens	46-51
23744644-5	2013	RA activity was abrogated by an antagonist of the RAR.	Radium	0-2	retinoic acid receptor, alpha	Mus musculus	50-53
23744644-8	2013	These results suggest that RA selectively induces IgA isotype switching through RAR and that RA and TGF-beta have important effects on the overall gut IgA antibody response.	Radium	27-29	retinoic acid receptor, alpha	Mus musculus	80-83
23722388-8	2013	Further, 13-cis RA also reduced the phosphorylation of Akt and increased the generation of interleukin-1beta and matrix metallopeptidase 9.	Radium	16-18	AKT serine/threonine kinase 1	Homo sapiens	55-58
23644984-7	2013	It was in consistent with our expectation that RA could up-regulate Boule and Stra8 expression, but down-regulate Nanos2 expression in mGSCs.	Radium	47-49	protein boule-like	Capra hircus	68-73
23644984-7	2013	It was in consistent with our expectation that RA could up-regulate Boule and Stra8 expression, but down-regulate Nanos2 expression in mGSCs.	Radium	47-49	stimulated by retinoic acid gene 8 protein homolog	Capra hircus	78-83
23644984-7	2013	It was in consistent with our expectation that RA could up-regulate Boule and Stra8 expression, but down-regulate Nanos2 expression in mGSCs.	Radium	47-49	nanos homolog 2	Capra hircus	114-120
23722388-8	2013	Further, 13-cis RA also reduced the phosphorylation of Akt and increased the generation of interleukin-1beta and matrix metallopeptidase 9.	Radium	16-18	interleukin 1 beta	Homo sapiens	91-108
23722388-8	2013	Further, 13-cis RA also reduced the phosphorylation of Akt and increased the generation of interleukin-1beta and matrix metallopeptidase 9.	Radium	16-18	matrix metallopeptidase 9	Homo sapiens	113-138
23207146-9	2013	PDX-1/Hes-1 interactions on cell proliferation were determined by exposure to All-trans Retinoic Acid (At-RA), an inductor of Hes-1.	Radium	106-108	pancreatic and duodenal homeobox 1	Mus musculus	0-5
23650978-0	2013	Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases.	Radium	114-116	interleukin 6	Homo sapiens	31-49
23724366-5	2013	Our results revealed that RA of GDF9 during different hours of IVM showed significant reduction between 0 h and 24 h of maturation in oocytes and BMP15 transcript increased significantly (P&lt;0.05) between 6 h and 12 h and decreased again between 12 h and 24.	Radium	26-28	growth/differentiation factor 9	Bubalus bubalis	32-36
23287363-12	2013	CONCLUSION: Alcohol intake is inversely associated with ACPA-positive RA, suggesting a protective effect.	Radium	70-72	proteinase 3	Homo sapiens	56-60
23650978-0	2013	Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases.	Radium	114-116	interleukin 6	Homo sapiens	51-55
23207146-13	2013	At-RA neutralized the increases in PDX-1 expression and cell proliferation, both in vitro and in vivo in DDC mice.	Radium	3-5	pancreatic and duodenal homeobox 1	Mus musculus	35-40
23207146-9	2013	PDX-1/Hes-1 interactions on cell proliferation were determined by exposure to All-trans Retinoic Acid (At-RA), an inductor of Hes-1.	Radium	106-108	hes family bHLH transcription factor 1	Mus musculus	6-11
23207146-9	2013	PDX-1/Hes-1 interactions on cell proliferation were determined by exposure to All-trans Retinoic Acid (At-RA), an inductor of Hes-1.	Radium	106-108	hes family bHLH transcription factor 1	Mus musculus	126-131
22451023-7	2013	A significantly increased risk of RA associated with the IRAK1 rs3027898 AA genotype was more evident among females, younger patients, CRP negative patients and both anti-CCP positive and negative patients compared with the IRAK1 rs3027898 CC/CA genotypes.	Radium	34-36	interleukin 1 receptor associated kinase 1	Homo sapiens	57-62
23341540-2	2013	RA is associated with a failure of apoptosis of infiltrating leukocytes, thought to be a result of overexpression of prosurvival Bcl-2 proteins.	Radium	0-2	B cell leukemia/lymphoma 2	Mus musculus	129-134
23498785-16	2013	The percentages of proliferating cell nuclear antigen (PCNA)-positive cells were higher in the MSC groups: 16.83 +- 4.62%, 19.17 +- 6.21%, and 2.17 +- 1.16% for the TV, RA, and control groups, respectively.	Radium	169-171	proliferating cell nuclear antigen	Rattus norvegicus	19-53
23498785-16	2013	The percentages of proliferating cell nuclear antigen (PCNA)-positive cells were higher in the MSC groups: 16.83 +- 4.62%, 19.17 +- 6.21%, and 2.17 +- 1.16% for the TV, RA, and control groups, respectively.	Radium	169-171	proliferating cell nuclear antigen	Rattus norvegicus	55-59
23220432-8	2013	However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR = 1.402, 95% CI = 1.001-1.964, p = 0.049).	Radium	84-86	guanylate cyclase 2C	Homo sapiens	30-33
23257245-3	2013	METHODS: Non-reduced (NR) and RA preparations of PRG4 were separated using high performance liquid chromatography-size-exclusion chromatography with an in-line multi-angle laser light scattering (MALLS) detector, which was used for absolute determination of PRG4 M(W).	Radium	30-32	proteoglycan 4	Bos taurus	49-53
23127800-5	2013	Remarkably, in a gpa2Delta, but not in a gpr1Delta mutant, active Ras accumulates in internal membranes and mitochondria, both when cells are growing on glucose medium or are starved, indicating that Gpa2, but not Gpr1 is required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus.	Radium	66-69	guanine nucleotide-binding protein subunit alpha	Saccharomyces cerevisiae S288C	200-204
23127800-5	2013	Remarkably, in a gpa2Delta, but not in a gpr1Delta mutant, active Ras accumulates in internal membranes and mitochondria, both when cells are growing on glucose medium or are starved, indicating that Gpa2, but not Gpr1 is required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus.	Radium	66-69	Gpr1p	Saccharomyces cerevisiae S288C	214-218
22712632-3	2013	Genes of RA-degrading enzyme CYP26b1, ALDH1 involved in RA synthesis and genes of carrier protein CRABPII involved in RA metabolism were turned on during the post-natal testicular development in dogs.	Radium	9-11	cytochrome P450 family 26 subfamily B member 1	Canis lupus familiaris	29-36
22451023-7	2013	A significantly increased risk of RA associated with the IRAK1 rs3027898 AA genotype was more evident among females, younger patients, CRP negative patients and both anti-CCP positive and negative patients compared with the IRAK1 rs3027898 CC/CA genotypes.	Radium	34-36	interleukin 1 receptor associated kinase 1	Homo sapiens	224-229
23409053-0	2013	Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells.	Radium	91-93	dipeptidyl peptidase like 6	Homo sapiens	25-29
23409053-3	2013	We observed an increase in the mRNA and protein level of Dnmt3b, whereas the expression of Dnmt1 and Dnmt3a was decreased after RA treatment of P19 cells which indicated that Dnmt3b is more important during neuronal differentiation of P19 cells.	Radium	128-130	DNA methyltransferase 1	Homo sapiens	91-96
23409053-3	2013	We observed an increase in the mRNA and protein level of Dnmt3b, whereas the expression of Dnmt1 and Dnmt3a was decreased after RA treatment of P19 cells which indicated that Dnmt3b is more important during neuronal differentiation of P19 cells.	Radium	128-130	DNA methyltransferase 3 alpha	Homo sapiens	101-107
23409053-3	2013	We observed an increase in the mRNA and protein level of Dnmt3b, whereas the expression of Dnmt1 and Dnmt3a was decreased after RA treatment of P19 cells which indicated that Dnmt3b is more important during neuronal differentiation of P19 cells.	Radium	128-130	DNA methyltransferase 3 beta	Homo sapiens	175-181
23409053-10	2013	RA induced neuronal differentiation was inhibited upon ectopic expression of Dpp6 in P19 cells.	Radium	0-2	dipeptidyl peptidase like 6	Homo sapiens	77-81
23409053-11	2013	Taken together, the present study described epigenetic silencing of Dpp6 expression by DNA methylation and established that its ectopic expression can act as negative signal during RA induced neuronal differentiation of P19 cells.	Radium	181-183	dipeptidyl peptidase like 6	Homo sapiens	68-72
22986289-3	2013	We review evidence from previous studies of the relationship between RA and traditional CV comorbidities such as dyslipidaemia, obesity, insulin resistance and diabetes, hypertension, cigarette smoking and physical inactivity.	Radium	69-71	insulin	Homo sapiens	137-144
22959974-2	2012	Although some recent studies demonstrate that VIP has a protective role in animal RA models, its variant in different disease grade of OA remains uncertain.	Radium	82-84	vasoactive intestinal peptide	Homo sapiens	46-49
23022338-6	2012	Of the 9 CCP3+/CCP2- patients, 6 (66.7%) had RA, one patient had ankylosing spondylitis, one osteoarthritis and one psoriatic arthritis.	Radium	45-47	AGBL carboxypeptidase 3	Homo sapiens	9-13
23022338-7	2012	The CCP3-/CCP2+ patient had juvenile RA.	Radium	37-39	AGBL carboxypeptidase 3	Homo sapiens	4-8
23022338-7	2012	The CCP3-/CCP2+ patient had juvenile RA.	Radium	37-39	AGBL carboxypeptidase 2	Homo sapiens	10-14
23258323-7	2012	Under the convert microscope it was observed that WISH cells started to change their shape, and there were several axon or dendrite-like processes out from the cell body induced by astragalus for 24 h or RA for 12 h. The positive cell rates of NSE and MAP-2 in 100 muL/mL astragalus-induced group were less than those in RA-induced group at 48 h (P &lt; 0.05), but higher than those in control group.	Radium	204-206	enolase 2	Homo sapiens	244-247
23258323-7	2012	Under the convert microscope it was observed that WISH cells started to change their shape, and there were several axon or dendrite-like processes out from the cell body induced by astragalus for 24 h or RA for 12 h. The positive cell rates of NSE and MAP-2 in 100 muL/mL astragalus-induced group were less than those in RA-induced group at 48 h (P &lt; 0.05), but higher than those in control group.	Radium	204-206	microtubule associated protein 2	Homo sapiens	252-257
22551950-9	2012	Changes in ATGL and HSL protein expression was positively associated with changes in whole body Ra(FFA) (P&lt;.03).	Radium	96-98	patatin like phospholipase domain containing 2	Homo sapiens	11-15
22987726-4	2012	The results revealed a transient induction of NOS3 (known as the constitutively expressed endothelial nitric oxide synthase; eNOS) during the time course of the RA treatment.	Radium	161-163	nitric oxide synthase 3	Homo sapiens	46-50
22987726-4	2012	The results revealed a transient induction of NOS3 (known as the constitutively expressed endothelial nitric oxide synthase; eNOS) during the time course of the RA treatment.	Radium	161-163	nitric oxide synthase 3	Homo sapiens	90-123
22551950-9	2012	Changes in ATGL and HSL protein expression was positively associated with changes in whole body Ra(FFA) (P&lt;.03).	Radium	96-98	lipase E, hormone sensitive type	Homo sapiens	20-23
23033662-5	2012	Furthermore, the changes of AD, FA and RA showed a significant negative correlation with the beta-APP immunohistochemical results.	Radium	39-41	amyloid beta precursor protein	Rattus norvegicus	93-101
22575527-7	2012	Using flow cytometry we could prove that CD14/Fc bound to whole Gram-negative bacteria, especially to short lipopolysaccharide (Ra and Re) mutants, and weak interaction was observed between the fusion protein and Listeria monocytogenes.	Radium	128-130	CD14 molecule	Homo sapiens	41-45
22740443-10	2012	The fraction of TPO-RA-treated patients who will be treatment-free after 12-24 months of therapy is unknown but likely to be low.	Radium	20-22	thyroid peroxidase	Homo sapiens	16-19
21947347-9	2012	The results from our study suggest that the C3435T MDR1 gene polymorphism may not be related with the RA susceptibility, but may influence the efficacy of RA therapy with DMARDs, and the 3435CC genotype may be related with RRA.	Radium	155-157	ATP binding cassette subfamily B member 1	Homo sapiens	51-55
22812434-2	2012	METHODS: Using a time-trend controlled case-crossover study design, we calculated odds ratios to evaluate whether exposure to ambient air pollutants and certain meteorological conditions on the day of admission (Lag 0) and up to 3 days before admission (Lag1 through Lag 3) were associated with acute RA exacerbation.	Radium	301-303	ceramide synthase 1	Homo sapiens	254-258
22812434-5	2012	In winter, a 1 C decrease in ambient temperature and a 1 ppb increase in sulfur dioxide concentration on the day of Lag 1 were associated with 14.8% (95% confidence interval [CI]: 0.9-26.7) and 19.7% (95% CI: 3.3-38.7) increases in the risk of RA exacerbation among nonsmokers, respectively.	Radium	244-246	ceramide synthase 1	Homo sapiens	116-121
22489869-11	2012	The clinical significance of the higher postoperative mean serum IL-6 and IL-10 levels in the RA group remains to be clarified in a future study.	Radium	94-96	interleukin 6	Homo sapiens	65-69
22489869-11	2012	The clinical significance of the higher postoperative mean serum IL-6 and IL-10 levels in the RA group remains to be clarified in a future study.	Radium	94-96	interleukin 10	Homo sapiens	74-79
22847212-2	2012	BACKGROUND: The chance of a good response in RA is attenuated in previous anti-TNF users who start new anti-TNF therapy compared to biologic naive patients.	Radium	45-47	tumor necrosis factor	Homo sapiens	79-82
22847212-2	2012	BACKGROUND: The chance of a good response in RA is attenuated in previous anti-TNF users who start new anti-TNF therapy compared to biologic naive patients.	Radium	45-47	tumor necrosis factor	Homo sapiens	108-111
22661711-8	2012	The differential ability of RAR-RXR bound to DR0 compared to DR2, DR5, and DR8 to mediate RA-dependent transcriptional activation indicates that half-site spacing allosterically regulates RAR function.	Radium	28-30	retinoic acid receptor, alpha	Mus musculus	188-191
21946941-6	2012	Only trace amounts of MMP-9 activity were detected in 4 of 10 patients with RA, whereas higher MMP-9 levels were evident in all samples from SA (P = 0.0241).	Radium	76-78	matrix metallopeptidase 9	Homo sapiens	22-27
22653613-6	2012	Very interestingly, GO significantly enhanced the differentiation of SH-SY5Y induced-retinoic acid (RA) by evaluating neurite length and the expression of neuronal marker MAP2.	Radium	100-102	microtubule associated protein 2	Homo sapiens	171-175
22716252-6	2012	The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice.	Radium	61-63	cellular retinoic acid binding protein II	Mus musculus	18-58
22716252-6	2012	The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice.	Radium	61-63	fatty acid binding protein 5, epidermal	Mus musculus	92-97
22716252-6	2012	The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice.	Radium	61-63	fatty acid binding protein 5, epidermal	Mus musculus	133-138
22258391-9	2012	Highly elevated BMD loss (&gt;=2.5 mg/cm2/month) was present in 16.3% of patients and associated with RA development [odds ratio (OR) 6.1, 95% CI 1.2, 29.2, positive predictive value (PPV) 85%, negative predictive value (NPV) 52%, sensitivity 26%, specificity 95%].	Radium	102-104	olfactory receptor family 2 subfamily I member 1 pseudogene	Homo sapiens	118-137
22337226-7	2012	RESULTS: As compared with mice exposed to RA, hypoxia placebo mice had a significant increase in the lung protein expression of CXCR7.	Radium	42-44	atypical chemokine receptor 3	Mus musculus	128-133
22155198-4	2012	In RA synovial tissue, biological effects of these metabolites as a consequence of altered peripheral sex hormone synthesis (intracrine, e.g., at the level of macrophages and fibroblasts) mainly results in stimulation of cell proliferation and cytokine production (i.e. TNF).	Radium	3-5	tumor necrosis factor	Homo sapiens	270-273
22498670-3	2012	RESULTS: Diffuse and strong reactivity involving the full or nearly full thickness of urothelium was observed with CK5/6 in 90% of RA cases.	Radium	131-133	keratin 5	Homo sapiens	115-120
22724068-2	2012	Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly adapting (RA) mechanosensitive currents to intermediate-adapting currents in dorsal root ganglion sensory neurons.	Radium	127-129	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	85-90
22724068-3	2012	Deletion of both TRPC3 and TRPC6 caused deficits in light touch and silenced half of small-diameter sensory neurons expressing mechanically activated RA currents.	Radium	150-152	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	17-22
22724068-3	2012	Deletion of both TRPC3 and TRPC6 caused deficits in light touch and silenced half of small-diameter sensory neurons expressing mechanically activated RA currents.	Radium	150-152	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	27-32
21193990-0	2012	A PTPN22 promoter polymorphism -1123G&gt;C is associated with RA pathogenesis in Chinese.	Radium	62-64	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	2-8
23019895-6	2012	CONCLUSION: It is realized that Scorpio and Scolopendra effectively treat RA by regulating the level of CD4 + CD25 + FoxP3 + Treg cell to restore immunological tolerance.	Radium	74-76	Cd4 molecule	Rattus norvegicus	104-107
23019895-6	2012	CONCLUSION: It is realized that Scorpio and Scolopendra effectively treat RA by regulating the level of CD4 + CD25 + FoxP3 + Treg cell to restore immunological tolerance.	Radium	74-76	forkhead box P3	Rattus norvegicus	117-122
21193990-1	2012	The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C&gt;T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia.	Radium	180-182	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	99-105
22039172-8	2012	All-trans retinoic acid (atRA) induced CYPS1 mRNA expression more potently than 9-cis RA or 13-cis RA.	Radium	27-29	peptidylprolyl isomerase B	Homo sapiens	39-44
22783724-7	2012	P19 GFPFoxA1 cells showed an earlier onset of differentiation during RA-induced neuronal differentiation, evidenced by a more rapid change on the Nanog decrease and the tubulin betaIII increase.	Radium	69-71	interleukin 23 subunit alpha	Homo sapiens	0-3
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	356-358	Tudor staphylococcal nuclease	Drosophila melanogaster	203-207
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	356-358	anon-86Ca	Drosophila melanogaster	259-266
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	356-358	p38a MAP kinase	Drosophila melanogaster	323-330
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	356-358	l(2)46Co	Drosophila melanogaster	374-381
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	356-358	l(2)46Cp	Drosophila melanogaster	431-438
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	406-408	Tudor staphylococcal nuclease	Drosophila melanogaster	203-207
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	406-408	anon-86Ca	Drosophila melanogaster	259-266
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	406-408	p38a MAP kinase	Drosophila melanogaster	323-330
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	406-408	l(2)46Co	Drosophila melanogaster	374-381
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Radium	406-408	l(2)46Cp	Drosophila melanogaster	431-438
22783724-7	2012	P19 GFPFoxA1 cells showed an earlier onset of differentiation during RA-induced neuronal differentiation, evidenced by a more rapid change on the Nanog decrease and the tubulin betaIII increase.	Radium	69-71	Nanog homeobox	Homo sapiens	146-151
21497537-1	2012	OBJECTIVE: The aim of the present study was to compare the serum level of COMP in both subsets of Systemic sclerosis (SSc) as a marker of arthritis and reveal an associated subclinical RA overlap and a relation to clinical, laboratory and radiological findings in SSc.	Radium	185-187	cartilage oligomeric matrix protein	Homo sapiens	74-78
22500176-4	2012	To study literature evidence assessing the risk of surgical site infections in orthopedic surgery patients with RA using anti-TNF drugs, compared to untreated patients or those using conventional DMARD.	Radium	112-114	tumor necrosis factor	Homo sapiens	126-129
21862573-0	2011	Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis.	Radium	66-69	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	23-26
22185370-4	2012	Initial response to TPO-ra defined as platelet counts &gt;30 x 10(9)/l after 4 weeks of treatment was found in 59% of primary ITP patients, 57% of patients with secondary ITP and 40% of patients with non-ITP.	Radium	24-26	thyroid peroxidase	Homo sapiens	20-23
22761867-6	2012	Assessment of the EGFR-Ras-ERK1/2 signaling cascade identified Ras GTP binding as the locus of the DHA-induced disruption of signal transduction.	Radium	23-26	epidermal growth factor receptor	Mus musculus	18-22
22761867-6	2012	Assessment of the EGFR-Ras-ERK1/2 signaling cascade identified Ras GTP binding as the locus of the DHA-induced disruption of signal transduction.	Radium	23-26	mitogen-activated protein kinase 3	Mus musculus	27-33
22271596-8	2012	The interaction between RA-Grb14 and RLD-CNGA1 is mediated through a simple protein-protein interaction temporally and spatially regulated by light and cGMP.	Radium	24-26	growth factor receptor bound protein 14	Homo sapiens	27-32
22271596-8	2012	The interaction between RA-Grb14 and RLD-CNGA1 is mediated through a simple protein-protein interaction temporally and spatially regulated by light and cGMP.	Radium	24-26	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	41-46
21365266-13	2011	Our results suggest that 9-cis-RA, all-trans-RA,lithium chloride and CEBPalpha might play important regulatory roles in let-7a2 gene expression in A549 cells.	Radium	31-33	microRNA let-7a-2	Homo sapiens	120-127
21365266-13	2011	Our results suggest that 9-cis-RA, all-trans-RA,lithium chloride and CEBPalpha might play important regulatory roles in let-7a2 gene expression in A549 cells.	Radium	45-47	microRNA let-7a-2	Homo sapiens	120-127
21873267-11	2011	CONCLUSIONS: Scintigraphy using (99m)Tc-anti-TNF-alpha showed high correlation with the presence of inflammatory signs detected by MRI in the hands and wrists of patients with active RA, and demonstrated a greater sensitivity than clinical examination.	Radium	183-185	tumor necrosis factor	Homo sapiens	45-54
21564055-3	2011	OBJECTIVES: In this study, we investigated the role of 13-cis RA-induced TRAIL within SEB-1 sebocytes.	Radium	62-64	TNF superfamily member 10	Homo sapiens	73-78
21523363-8	2011	Corticoid dose was not associated to dyslipidaemia, but in multiple regression models, corticoid dose may be negatively related to some atherogenic markers, in particular non-HDL-c. Tunisian patients with markedly active RA experience substantially reduced serum HDL-c and increased TC, LDL-c and Lp (a) concentrations as well as increased TC/HDL-c, LDL-c/HDL-c and non-HDL-c/HDL-c ratios.	Radium	221-223	component of oligomeric golgi complex 2	Homo sapiens	287-292
21523363-8	2011	Corticoid dose was not associated to dyslipidaemia, but in multiple regression models, corticoid dose may be negatively related to some atherogenic markers, in particular non-HDL-c. Tunisian patients with markedly active RA experience substantially reduced serum HDL-c and increased TC, LDL-c and Lp (a) concentrations as well as increased TC/HDL-c, LDL-c/HDL-c and non-HDL-c/HDL-c ratios.	Radium	221-223	component of oligomeric golgi complex 2	Homo sapiens	350-355
21669875-7	2011	Blockage of RA signaling before 2So also leads to mild defects of heart laterality, which become much more severe through perturbation of cardiac bmp4 asymmetry when RA signaling is blocked after 2So.	Radium	12-14	bone morphogenetic protein 4	Danio rerio	146-150
21708156-8	2011	Among the T1D patients ZnT8-RA was detected in 1351 (52%) patients, ZnT8-WA in 1209 (47%) and ZnT8-QA in 790 (31%) demonstrating that 1661 (64%) had one or several ZnT8A.	Radium	28-30	solute carrier family 30 member 8	Homo sapiens	23-27
21669875-7	2011	Blockage of RA signaling before 2So also leads to mild defects of heart laterality, which become much more severe through perturbation of cardiac bmp4 asymmetry when RA signaling is blocked after 2So.	Radium	166-168	bone morphogenetic protein 4	Danio rerio	146-150
21669875-9	2011	These findings suggest that RA signaling controls visceral laterality through the left-sided Nodal signal before 2So, and regulates heart laterality through cardiac bmp4 mainly after 2So, first identifying sequential control and concordance of visceral and heart laterality.	Radium	28-30	bone morphogenetic protein 4	Danio rerio	165-169
21668453-5	2011	Treatment with BMP4 or RA induces a significant increase in ACTRIA, ACTRIIA and ACTRIIB transcripts, whereas activin A decreases ACTRIB.	Radium	23-25	activin A receptor type 2B	Homo sapiens	80-87
21668453-5	2011	Treatment with BMP4 or RA induces a significant increase in ACTRIA, ACTRIIA and ACTRIIB transcripts, whereas activin A decreases ACTRIB.	Radium	23-25	activin A receptor type 1B	Homo sapiens	129-135
21439638-7	2011	Our data showed that the expression of SMC specific marker genes, including myocardin, smoothelin, SM22alpha and SMMHC, were higher for the group induced by RA than for the group treated by DMSO, while pluripotent marker gene expression was repressed by the RA-treatment.	Radium	157-159	smoothelin	Mus musculus	87-97
21439638-7	2011	Our data showed that the expression of SMC specific marker genes, including myocardin, smoothelin, SM22alpha and SMMHC, were higher for the group induced by RA than for the group treated by DMSO, while pluripotent marker gene expression was repressed by the RA-treatment.	Radium	157-159	transgelin	Mus musculus	99-108
21439638-7	2011	Our data showed that the expression of SMC specific marker genes, including myocardin, smoothelin, SM22alpha and SMMHC, were higher for the group induced by RA than for the group treated by DMSO, while pluripotent marker gene expression was repressed by the RA-treatment.	Radium	157-159	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	113-118
20656949-5	2011	The expression of BRP-39 was significantly induced in macrophages, airway epithelial cells, and alveolar Type II cells in the lungs of CS-exposed mice compared with RA-exposed mice, at least in part via an IL-18 signaling-dependent pathway.	Radium	165-167	chitinase-like 1	Mus musculus	18-24
21724524-6	2011	The D10 is 5% more with IMRT plan and 7% more with RA plan for central target in comparison with plan goal.	Radium	51-53	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion	Homo sapiens	4-7
21102549-7	2011	MLC-2V, another ventricular-specific marker, was expressed in the majority of the cardiomyocytes in Noggin+RAi-treated cultures, but not in the cardiomyocytes of Noggin+RA-treated cultures.	Radium	107-109	myosin light chain 2	Homo sapiens	0-6
21555593-2	2011	Although previous studies have implicated neural crest-derived periocular mesenchyme (POM) as the critical target of RA action in the eye, we show here that RAR signaling regulates choroid fissure closure in zebrafish by acting on both the ventral optic cup and the POM.	Radium	117-119	retinoic acid receptor alpha	Homo sapiens	157-160
21433280-2	2011	Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent--rosmarinic acid (RA)--on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptide-1 (GLP-1).	Radium	112-114	solute carrier family 5 member 1	Rattus norvegicus	166-193
21433280-2	2011	Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent--rosmarinic acid (RA)--on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptide-1 (GLP-1).	Radium	112-114	solute carrier family 5 member 1	Rattus norvegicus	195-200
21433280-2	2011	Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent--rosmarinic acid (RA)--on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptide-1 (GLP-1).	Radium	112-114	glucagon	Rattus norvegicus	246-269
21433280-2	2011	Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent--rosmarinic acid (RA)--on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptide-1 (GLP-1).	Radium	112-114	glucagon	Rattus norvegicus	271-276
21102549-9	2011	With 50.7 +- 1.76% cardiac differentiation efficiency, 94% of the cardiomyocytes in Noggin+RA-treated cultures had embryonic atrial-like APs.	Radium	91-93	noggin	Homo sapiens	84-90
20376700-3	2011	Truncated PPARdelta lacking the activation domain AF2 cannot suppress RA-induced activation of the hCOX-2 gene via DR1, suggesting that cofactor recruitment by AF2 is required for the suppression by PPARdelta.	Radium	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-105
21276787-5	2011	In contrast, ectopic expression of hyperactive zebrafish RARs induces expression of a RA-responsive reporter transgene as well as ectopic expression of endogenous RA-responsive target genes.	Radium	86-88	arginyl-tRNA synthetase 1	Danio rerio	57-61
21445804-7	2011	In the second set, sections of the medulla were immunolabeled for vasopressin V(1A ) receptor, and its expression was significantly higher in the RVLM and in the neighboring rostral ventral respiratory column in CIH- than from RA-conditioned rats.	Radium	227-229	arginine vasopressin receptor 1A	Rattus norvegicus	66-93
21587177-5	2011	RAx reduced lung V5 from (50.9% +- 9.8% in f-IMRT and (51.4% +- 10.8% in RA to (49.3% +- 10.4% in RAx (p &lt; 0.05).	Radium	0-2	retina and anterior neural fold homeobox	Homo sapiens	98-101
21245636-5	2011	The unexpectedly delayed activation of the paraseptal RA following activation of the paraseptal left atrium (DP1) can be explained by the absence of a LA-CS musculature (CSM) electrical connection at the proximal CS, which forces a detour of the activation wavefront from LA to RA via the distal CS (DP2).	Radium	54-56	prostaglandin D2 receptor	Homo sapiens	109-112
22372022-9	2011	After adjustment, inverse associations between RA and DBP/SBP for both genders were found.	Radium	47-49	selenium binding protein 1	Homo sapiens	58-61
21245636-5	2011	The unexpectedly delayed activation of the paraseptal RA following activation of the paraseptal left atrium (DP1) can be explained by the absence of a LA-CS musculature (CSM) electrical connection at the proximal CS, which forces a detour of the activation wavefront from LA to RA via the distal CS (DP2).	Radium	54-56	transcription factor Dp-2	Homo sapiens	300-303
21245636-5	2011	The unexpectedly delayed activation of the paraseptal RA following activation of the paraseptal left atrium (DP1) can be explained by the absence of a LA-CS musculature (CSM) electrical connection at the proximal CS, which forces a detour of the activation wavefront from LA to RA via the distal CS (DP2).	Radium	278-280	prostaglandin D2 receptor	Homo sapiens	109-112
20833643-8	2010	RESULTS: ACPA-negative RA with apparent bone erosion was not associated with SE, supporting the idea that ACPA-negative RA is genetically distinct from ACPA-positive RA.	Radium	23-25	proteinase 3	Homo sapiens	9-13
22140430-7	2011	Interestingly, within these ROCK-inhibited RA treated cultures, increased levels of mesodermal or ectodermal markers were not observed, instead it was found that the pluripotent markers SSEA-1 and Oct-4 remained up-regulated similar to that seen in undifferentiated cultures.	Radium	43-45	POU class 5 homeobox 1	Homo sapiens	197-202
20833643-3	2010	ACPA-positive RA was found to be associated with the HLA-DR shared epitope (SE), but ACPA negative was not.	Radium	14-16	proteinase 3	Homo sapiens	0-4
20833643-10	2010	In accordance with the ACPA-negative RA subset, the RF-negative RA subset showed a clearly distinct pattern of association with SE from the RF-positive RA.	Radium	37-39	proteinase 3	Homo sapiens	23-27
20833643-3	2010	ACPA-positive RA was found to be associated with the HLA-DR shared epitope (SE), but ACPA negative was not.	Radium	14-16	major histocompatibility complex, class II, DR beta 1	Homo sapiens	53-56
20001643-1	2010	The aim of this study was to describe how persons with RA from an area in western Sweden experience everyday life with TNF-alpha blockers.	Radium	55-57	tumor necrosis factor	Homo sapiens	119-128
20833643-12	2010	CONCLUSIONS: ACPA-negative erosive RA is genetically distinct from ACPA-positive RA.	Radium	35-37	proteinase 3	Homo sapiens	13-17
20833643-4	2010	However, the suspicion remained that this result was caused by the ACPA-negative RA subset containing patients with non-RA diseases.	Radium	81-83	proteinase 3	Homo sapiens	67-71
20833643-4	2010	However, the suspicion remained that this result was caused by the ACPA-negative RA subset containing patients with non-RA diseases.	Radium	120-122	proteinase 3	Homo sapiens	67-71
20707993-3	2010	Recent findings indicate that Cyp26b1, a RA-degrading enzyme, is a key factor preventing initiation of meiosis in the fetal testis.	Radium	41-43	cytochrome P450, family 26, subfamily b, polypeptide 1	Mus musculus	30-37
20801112-3	2010	We found that Gdf11 and Acvr2b mutants are sensitive to exogenous RA treatment on vertebral specification and caudal vertebral development.	Radium	66-68	growth differentiation factor 11	Mus musculus	14-19
20801112-3	2010	We found that Gdf11 and Acvr2b mutants are sensitive to exogenous RA treatment on vertebral specification and caudal vertebral development.	Radium	66-68	activin receptor IIB	Mus musculus	24-30
20506217-5	2010	Over-expression of Jmjd3 in P19 cells also significantly enhances the RA-induced expression and promoter activity of Mash1.	Radium	70-72	lysine demethylase 6B	Homo sapiens	19-24
20506217-5	2010	Over-expression of Jmjd3 in P19 cells also significantly enhances the RA-induced expression and promoter activity of Mash1.	Radium	70-72	achaete-scute family bHLH transcription factor 1	Homo sapiens	117-122
20506217-10	2010	Our results suggest that the demethylase activity of Jmjd3 and its mediator Hes1 for Mash1 promoter binding are both required for Jmjd3 enhanced efficient expression of Mash1 gene in the early stage of RA-induced neuronal differentiation of P19 cells.	Radium	202-204	lysine demethylase 6B	Homo sapiens	53-58
20506217-10	2010	Our results suggest that the demethylase activity of Jmjd3 and its mediator Hes1 for Mash1 promoter binding are both required for Jmjd3 enhanced efficient expression of Mash1 gene in the early stage of RA-induced neuronal differentiation of P19 cells.	Radium	202-204	hes family bHLH transcription factor 1	Homo sapiens	76-80
20506217-10	2010	Our results suggest that the demethylase activity of Jmjd3 and its mediator Hes1 for Mash1 promoter binding are both required for Jmjd3 enhanced efficient expression of Mash1 gene in the early stage of RA-induced neuronal differentiation of P19 cells.	Radium	202-204	achaete-scute family bHLH transcription factor 1	Homo sapiens	85-90
20506217-10	2010	Our results suggest that the demethylase activity of Jmjd3 and its mediator Hes1 for Mash1 promoter binding are both required for Jmjd3 enhanced efficient expression of Mash1 gene in the early stage of RA-induced neuronal differentiation of P19 cells.	Radium	202-204	lysine demethylase 6B	Homo sapiens	130-135
20506217-10	2010	Our results suggest that the demethylase activity of Jmjd3 and its mediator Hes1 for Mash1 promoter binding are both required for Jmjd3 enhanced efficient expression of Mash1 gene in the early stage of RA-induced neuronal differentiation of P19 cells.	Radium	202-204	achaete-scute family bHLH transcription factor 1	Homo sapiens	169-174
21327148-3	2010	In recent work we provided evidence that patients who lack HLA-DRB1*01 and/or *04 alleles can acquire RA susceptibility through fetal, maternal or iatrogenic microchimerism.	Radium	102-104	major histocompatibility complex, class II, DR beta 1	Homo sapiens	59-67
20548336-7	2010	Consistent with a role for PHF8 in neuronal differentiation, knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation, whereas overexpression of the wild-type but not the F279S mutant PHF8 drives P19 cells toward neuronal differentiation.	Radium	126-128	PHD finger protein 8	Mus musculus	74-78
20548336-7	2010	Consistent with a role for PHF8 in neuronal differentiation, knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation, whereas overexpression of the wild-type but not the F279S mutant PHF8 drives P19 cells toward neuronal differentiation.	Radium	126-128	PHD finger protein 8	Mus musculus	74-78
20535114-13	2010	Thus, inward remodeling because of blood flow reduction in mesenteric RA depends on unopposed angiotensin II-induced contraction and ERK1/2 activation, independent of superoxide production.	Radium	70-72	angiotensinogen	Rattus norvegicus	94-108
20535114-13	2010	Thus, inward remodeling because of blood flow reduction in mesenteric RA depends on unopposed angiotensin II-induced contraction and ERK1/2 activation, independent of superoxide production.	Radium	70-72	mitogen activated protein kinase 3	Rattus norvegicus	133-139
20308920-9	2010	The blunted endothelin-1 contractile response of small arteries found in transgenic+salt mice was partially restored by ET(A)RA and completely prevented by dual ET(A/B)R antagonism.	Radium	125-127	endothelin 1	Mus musculus	12-24
20885005-6	2010	Our real-time RT-PCR, Western blot, and immunocytochemistry analyses of undifferentiated and RA-differentiated cells have demonstrated the enhanced expression of both splice variants of DRD2, with the short one being stronger enhanced than the long one under RA-treatment, and the DRD2 distribution on cell bodies and neurites under both conditions.	Radium	93-95	dopamine receptor D2	Homo sapiens	186-190
20885005-6	2010	Our real-time RT-PCR, Western blot, and immunocytochemistry analyses of undifferentiated and RA-differentiated cells have demonstrated the enhanced expression of both splice variants of DRD2, with the short one being stronger enhanced than the long one under RA-treatment, and the DRD2 distribution on cell bodies and neurites under both conditions.	Radium	93-95	dopamine receptor D2	Homo sapiens	281-285
20308057-4	2010	In contrast to the effect seen in wild type keratinocytes, Ras(GTP) levels were barely detected in RasGRP1 KO cells even after 60 min of exposure to phorbol esters.	Radium	59-62	RAS guanyl releasing protein 1	Mus musculus	99-106
20009532-9	2010	In contrast, the kinase domain mutation is active in the absence of RAS-Gtp binding, but depends on the interaction with p85.	Radium	68-71	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	121-124
20176747-7	2010	We also investigated if 9-cis retinoic acid (9-cis RA), the ligand for the heterodimeric partner of TR and LXR, RXR, could regulate the hDIO2 promoter.	Radium	51-53	retinoid X receptor alpha	Homo sapiens	112-115
20176747-7	2010	We also investigated if 9-cis retinoic acid (9-cis RA), the ligand for the heterodimeric partner of TR and LXR, RXR, could regulate the hDIO2 promoter.	Radium	51-53	iodothyronine deiodinase 2	Homo sapiens	136-141
20176747-8	2010	Notably, 9-cis RA repressed the hDIO2 luciferase reporter (1 microM, approximately fourfold) in a dose-dependent manner, while coexpression of an inactive mutant RXR abolished this effect.	Radium	15-17	iodothyronine deiodinase 2	Homo sapiens	32-37
20176747-10	2010	Our data indicate that hDIO2 transcription is negatively regulated by both 22(R)-OH-cholesterol and 9-cis RA, which is consistent with LXR/RXR involvement.	Radium	106-108	iodothyronine deiodinase 2	Homo sapiens	23-28
20176747-10	2010	Our data indicate that hDIO2 transcription is negatively regulated by both 22(R)-OH-cholesterol and 9-cis RA, which is consistent with LXR/RXR involvement.	Radium	106-108	retinoid X receptor alpha	Homo sapiens	139-142
20376724-4	2010	Immunohistochemistry and mRNA expression of RhoA/ROK was significantly increased in GSV from diabetic patients compared to that of IMA and RA from diabetic patients.	Radium	139-141	ras homolog family member A	Homo sapiens	44-48
20376724-6	2010	CONCLUSIONS: RhoA/ROK expression and function in GSV from diabetic patients is significantly increased compared with IMA and RA from diabetic patients and GSV from nondiabetic patients.	Radium	125-127	ras homolog family member A	Homo sapiens	13-17
20078939-5	2009	CONCLUSIONS: Ezh2 produces a repressive histone mark H3K27me3 in the early stage of RA induced P12 cells.	Radium	84-86	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	95-98
19344752-2	2009	RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and RASSF7 to RASSF10 contain an N-terminal RA domain.	Radium	0-2	Ras association domain family member 10	Homo sapiens	79-86
20078939-5	2009	CONCLUSIONS: Ezh2 produces a repressive histone mark H3K27me3 in the early stage of RA induced P12 cells.	Radium	84-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
20047520-9	2010	CONCLUSION: Overexpression of PDCD5 could enhance apoptosis of RA FLS induced by triptolide; PDCD5 may be a potential therapeutic target to RA.	Radium	63-65	programmed cell death 5	Homo sapiens	30-35
19934264-4	2010	Binding assays indicated that SKIP interacts with RAR in a RA-dependent manner, through a region that overlaps the binding site for SIRT1.	Radium	50-52	sirtuin 1	Homo sapiens	132-137
19934264-11	2010	These data suggest that SIRT1 and SKIP play reciprocal roles in the regulation of RAR activity, which is implicated in the regulation of RA-induced neuronal differentiation of P19 cells.	Radium	82-84	sirtuin 1	Homo sapiens	24-29
20056091-7	2010	The level of MCP-1 in serum of RA patieuts was positively correlated with IgG, IgM, and gamma-G.	Radium	31-33	C-C motif chemokine ligand 2	Homo sapiens	13-18
19846660-0	2009	Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.	Radium	21-23	Ste50p	Saccharomyces cerevisiae S288C	34-40
19846660-0	2009	Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.	Radium	21-23	Opy2p	Saccharomyces cerevisiae S288C	57-62
19732752-8	2009	TNIP1 repression of RARs in the presence of RA places it in a small category of corepressors of agonist-bound NRs.	Radium	20-22	TNFAIP3 interacting protein 1	Homo sapiens	0-5
19244202-4	2009	In room air (RA), lung Trx interacting protein (Txnip) levels decreased developmentally through Day 7 (1.0 +/- 0.06 [Day 1] vs. 0.49 +/- 0.10 [Day 3] vs. 0.29 +/- 0.03 [Day 7]; P &lt; 0.01), whereas VEGF expression increased (1.25 +/- 0.16 [Day 1] vs. 4.35 +/- 1.51 [Day 3] vs. 13.23 +/- 0.37 [Day 7]; P &lt; 0.01).	Radium	13-15	thioredoxin interacting protein	Mus musculus	23-46
19244202-7	2009	Txnip and VEGF protein levels were inversely correlated in both the RA and hyperoxia-exposed groups (n = 18; R = -0.66; P = 0.003).	Radium	68-70	thioredoxin interacting protein	Mus musculus	0-5
19244202-7	2009	Txnip and VEGF protein levels were inversely correlated in both the RA and hyperoxia-exposed groups (n = 18; R = -0.66; P = 0.003).	Radium	68-70	vascular endothelial growth factor A	Mus musculus	10-14
19244202-4	2009	In room air (RA), lung Trx interacting protein (Txnip) levels decreased developmentally through Day 7 (1.0 +/- 0.06 [Day 1] vs. 0.49 +/- 0.10 [Day 3] vs. 0.29 +/- 0.03 [Day 7]; P &lt; 0.01), whereas VEGF expression increased (1.25 +/- 0.16 [Day 1] vs. 4.35 +/- 1.51 [Day 3] vs. 13.23 +/- 0.37 [Day 7]; P &lt; 0.01).	Radium	13-15	thioredoxin interacting protein	Mus musculus	48-53
19244202-4	2009	In room air (RA), lung Trx interacting protein (Txnip) levels decreased developmentally through Day 7 (1.0 +/- 0.06 [Day 1] vs. 0.49 +/- 0.10 [Day 3] vs. 0.29 +/- 0.03 [Day 7]; P &lt; 0.01), whereas VEGF expression increased (1.25 +/- 0.16 [Day 1] vs. 4.35 +/- 1.51 [Day 3] vs. 13.23 +/- 0.37 [Day 7]; P &lt; 0.01).	Radium	13-15	vascular endothelial growth factor A	Mus musculus	199-203
19713442-12	2009	CONCLUSIONS: These findings suggest that the presence of high levels of functionally active TREM-1 in RA synovium may contribute to the development or maintenance of RA, or both.	Radium	102-104	triggering receptor expressed on myeloid cells 1	Homo sapiens	92-98
19737838-1	2009	OBJECTIVE: Several studies have shown that a haplotype (rs11889341, rs7574865, rs8179673 and rs10181656) in STAT4 is associated with the development of RA in Caucasian, Korean and Japanese populations.	Radium	152-154	signal transducer and activator of transcription 4	Homo sapiens	108-113
19737838-2	2009	The aim of this study was to investigate the effect of STAT4 on susceptibility to RA in the Han Chinese population.	Radium	82-84	signal transducer and activator of transcription 4	Homo sapiens	55-60
19799655-5	2009	The lowest RA(LOX) (81%) was observed when tomato juice was treated at 250 Hz for 7 mus in bipolar mode.	Radium	11-13	linoleate 9S-lipoxygenase A	Solanum lycopersicum	14-17
19834598-13	2009	Notably, Gli1 did not induce N-MYC expression in neuroblastoma cells, but strongly induced RET, a known mediator of RA effect.	Radium	116-118	GLI family zinc finger 1	Homo sapiens	9-13
19834598-13	2009	Notably, Gli1 did not induce N-MYC expression in neuroblastoma cells, but strongly induced RET, a known mediator of RA effect.	Radium	116-118	ret proto-oncogene	Homo sapiens	91-94
19715447-5	2009	RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate.	Radium	138-140	interleukin 6	Homo sapiens	47-51
19715447-5	2009	RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate.	Radium	138-140	interleukin 6	Homo sapiens	63-67
19477911-10	2009	RA treatment up-regulated FOXP3 expression and down-regulated IL-17 expression in colon biopsies of patients and in colon tissues and MLN of mice with colitis compared with controls.	Radium	0-2	forkhead box P3	Homo sapiens	26-31
19447772-3	2009	To study the contribution of SAA to the recruitment of Th17 cells, we investigated the effects of SAA on CCL20 production by RA synoviotytes.	Radium	125-127	serum amyloid A1 cluster	Homo sapiens	98-101
19477911-10	2009	RA treatment up-regulated FOXP3 expression and down-regulated IL-17 expression in colon biopsies of patients and in colon tissues and MLN of mice with colitis compared with controls.	Radium	0-2	interleukin 17A	Homo sapiens	62-67
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	Radium	11-13	tumor necrosis factor	Mus musculus	79-88
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	Radium	11-13	interleukin 1 beta	Mus musculus	90-98
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	Radium	11-13	interleukin 17A	Mus musculus	100-105
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	Radium	11-13	interleukin 10	Mus musculus	138-143
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	Radium	11-13	transforming growth factor, beta 1	Mus musculus	145-153
19595764-6	2009	Furthermore, inhibition of RALDH2, which should decrease endogenous RA levels, caused a reduction of anterior domains indicating that endogenous RA is necessary for regulating their size.	Radium	68-70	aldehyde dehydrogenase 1 family member A2 L homeolog	Xenopus laevis	27-33
19494026-5	2009	The plasma inositol concentration was 175.74 (59.71-300.60) micromol/L and Ra was 1.06 (0.33-1.75) micromol x kg(-1).min(-1) (1521 micromol x kg(-1) x d(-1)).	Radium	75-77	CD59 molecule (CD59 blood group)	Homo sapiens	117-123
19401386-3	2009	Recent studies reported that GALT CD103+ DCs mediated enhanced iTreg conversion via the secretion of RA.	Radium	101-103	galactose-1-phosphate uridylyltransferase	Homo sapiens	29-33
19401386-6	2009	Using in vitro and in vivo approaches, we now demonstrate that PPARgamma activation enhances iTreg generation through increased RA synthesis from murine splenic DCs.	Radium	128-130	peroxisome proliferator activated receptor gamma	Mus musculus	63-72
19401386-8	2009	Overall, our findings suggest that PPARgamma may be important as a factor that stimulates DCs to produce RA and as a potential mechanism by which PPARgamma ligands ameliorate autoimmunity.	Radium	105-107	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44
19425111-7	2009	olig2, olig3, and olig4 expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS.	Radium	134-136	oligodendrocyte lineage transcription factor 2	Danio rerio	0-5
19425111-7	2009	olig2, olig3, and olig4 expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS.	Radium	134-136	oligodendrocyte transcription factor 3	Danio rerio	7-12
19425111-7	2009	olig2, olig3, and olig4 expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS.	Radium	134-136	oligodendrocyte transcription factor 4	Danio rerio	18-23
19199100-4	2009	ELISA detected a higher level of PADI4 in SF of RA than in samples of OA and AS (P = 0.0001).	Radium	48-50	peptidyl arginine deiminase 4	Homo sapiens	33-38
19648926-3	2009	Here we report the crystal structure of the RA and PH domains of Grb10 at 2.6-A resolution.	Radium	44-46	growth factor receptor bound protein 10	Homo sapiens	65-70
19447772-3	2009	To study the contribution of SAA to the recruitment of Th17 cells, we investigated the effects of SAA on CCL20 production by RA synoviotytes.	Radium	125-127	C-C motif chemokine ligand 20	Homo sapiens	105-110
18793807-8	2009	CONCLUSION: Serum BNP correlates with RA contractility and RV diastolic dysfunction by RV TDI in adults with acquired PH.	Radium	38-40	natriuretic peptide B	Homo sapiens	18-21
19308998-2	2009	We first show that the expression of ngn1 increases drastically in RA induced neuronal differentiation.	Radium	67-69	neurogenin 1	Homo sapiens	37-41
19308998-4	2009	Recruiting of a repressive histone code H3K27me3 on the ngn1 gene is the dominant change in first repression stage, which is followed by the binding of the active codes of H3K9ac, H3K14ac, and the H3K4me3 in the second and third stages of RA treatment.	Radium	239-241	neurogenin 1	Homo sapiens	56-60
19351850-11	2009	RA also induced rapid activation of Akt in MCF-7 cells.	Radium	0-2	AKT serine/threonine kinase 1	Homo sapiens	36-39
19569515-3	2009	It was found that increasing the NO concentration (in RA group) prevents the disruption of the dystrophin layer and decreases the loss of desmin in m. soleus under eccentric contraction, whereas in the R and RN groups the level of damage to dystrophin and desmin was significantly higher compared to the control rats.	Radium	54-56	dystrophin	Rattus norvegicus	95-105
19569515-3	2009	It was found that increasing the NO concentration (in RA group) prevents the disruption of the dystrophin layer and decreases the loss of desmin in m. soleus under eccentric contraction, whereas in the R and RN groups the level of damage to dystrophin and desmin was significantly higher compared to the control rats.	Radium	54-56	desmin	Rattus norvegicus	138-144
19351850-13	2009	These findings indicate that RA induction of NIS in MCF-7 cells is mediated by rapid activation of the PI3K pathway and involves direct interaction with RAR and retinoid X receptor.	Radium	29-31	retinoic acid receptor alpha	Homo sapiens	153-156
19351850-13	2009	These findings indicate that RA induction of NIS in MCF-7 cells is mediated by rapid activation of the PI3K pathway and involves direct interaction with RAR and retinoid X receptor.	Radium	29-31	retinoid X receptor alpha	Homo sapiens	161-180
19379570-4	2009	Among de-novo MDS patients, the expression level of cyclin A1 mRNA in the MDS-RAEB group (1.895 +/- 1.769) was higher than that in MDS-RA group (0.629 +/- 1.583) (p &lt; 0.01).	Radium	78-80	cyclin A1	Homo sapiens	52-61
19999184-14	2009	The efficacy, safety, and quality of life benefits of TNFalpha antagonists suggest using them possibly earlier than today, even in clinically moderate RA.	Radium	151-153	tumor necrosis factor	Homo sapiens	54-62
19241459-10	2009	The results clearly show an AMO-dependent decrease in Ras-GTP levels, which is consistent with the restoration of neurofibromin function.	Radium	54-57	neurofibromin 1	Homo sapiens	114-127
19545055-3	2009	The best pharmacophore model of integrin alphavbeta3 receptor antagonists with RMS = 0.73, Correl = 0.90, Weight = 1.17, Config = 14.00 is found out, which consisting of four features: a neg ionizable core (NI), two aliphatic hydrophobic core (HP) and an aromatic ring center (RA).	Radium	277-279	integrin subunit alpha V	Homo sapiens	32-52
19022332-1	2009	p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain.	Radium	82-86	RAS p21 protein activator 1	Homo sapiens	0-11
19258542-7	2009	Induction of RAR-beta2 expression in oral leukoplakia tissues after the patients treated with 13-cis RA correlated with a reduction in COX-2 expression and clinical response.	Radium	13-15	prostaglandin-endoperoxide synthase 2	Mus musculus	135-140
18922886-1	2008	The retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) and the retinoic acid receptors RAR and RXR significantly induce transcriptional activity from a 200-bp PKD1 proximal promoter in transfected mammalian cells.	Radium	47-49	retinoic acid receptor alpha	Homo sapiens	115-118
19204112-3	2009	TGF-beta has been shown to induce expression of Foxp3 as well as IL10 and the vitamin A metabolite; all-trans retinoic acid (RA [at-RA]) has been found to enhance the former.	Radium	125-127	forkhead box P3	Mus musculus	48-53
19204112-3	2009	TGF-beta has been shown to induce expression of Foxp3 as well as IL10 and the vitamin A metabolite; all-trans retinoic acid (RA [at-RA]) has been found to enhance the former.	Radium	125-127	interleukin 10	Mus musculus	65-69
19204112-3	2009	TGF-beta has been shown to induce expression of Foxp3 as well as IL10 and the vitamin A metabolite; all-trans retinoic acid (RA [at-RA]) has been found to enhance the former.	Radium	132-134	transforming growth factor, beta 1	Mus musculus	0-8
19204112-3	2009	TGF-beta has been shown to induce expression of Foxp3 as well as IL10 and the vitamin A metabolite; all-trans retinoic acid (RA [at-RA]) has been found to enhance the former.	Radium	132-134	forkhead box P3	Mus musculus	48-53
19118369-2	2009	The main CLA products in faecal suspensions, rumenic acid (cis-9,trans-11-CLA; RA) and trans-9,trans-11-CLA, were labelled at C-13, as were other 9,11 geometric isomers.	Radium	79-81	homeobox C13	Homo sapiens	126-130
19381305-6	2009	As reviewed here, the generation of such germline mutations, combined with pharmacological approaches to block the RA signalling pathway, has provided genetic evidence that RAR/RXR heterodimers are indeed the functional units transducing the RA signal during prenatal development.	Radium	115-117	retinoic acid receptor, alpha	Mus musculus	173-176
19126387-7	2009	CONCLUSION: TWEAK can induce RA FLS to synthesize MMP-3 and damage the articular bone and cartilage directly.	Radium	29-31	TNF superfamily member 12	Homo sapiens	12-17
19126387-7	2009	CONCLUSION: TWEAK can induce RA FLS to synthesize MMP-3 and damage the articular bone and cartilage directly.	Radium	29-31	matrix metallopeptidase 3	Homo sapiens	50-55
19288751-5	2009	The position of retinoic acid production and CYP26b1 expression that metabolizes RA to an inactive form regulates Stra8 expression.	Radium	81-83	cytochrome P450 family 26 subfamily B member 1	Homo sapiens	45-52
19288751-5	2009	The position of retinoic acid production and CYP26b1 expression that metabolizes RA to an inactive form regulates Stra8 expression.	Radium	81-83	stimulated by retinoic acid 8	Homo sapiens	114-119
18594976-6	2009	9-cis RA inhibited c-jun levels and also inhibited expression of its receptor RXR alpha in HSC-T6 cells.	Radium	6-8	retinoid X receptor alpha	Rattus norvegicus	78-87
19246282-4	2009	RESULTS: Both tazarotene and at-RA dose-dependently reduced the expression of MMP-1 and increased the expression of TIMP-1 in cultured human fibroblasts exposed to heat shock, and tazarotene produced stronger effect than at-RA.	Radium	32-34	matrix metallopeptidase 1	Homo sapiens	78-83
19246282-4	2009	RESULTS: Both tazarotene and at-RA dose-dependently reduced the expression of MMP-1 and increased the expression of TIMP-1 in cultured human fibroblasts exposed to heat shock, and tazarotene produced stronger effect than at-RA.	Radium	32-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	116-122
18854619-7	2009	Six out of 11 patients showed significantly increased (above 50%) Tg levels just after RA therapy.	Radium	87-89	thyroglobulin	Homo sapiens	66-68
18922886-1	2008	The retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) and the retinoic acid receptors RAR and RXR significantly induce transcriptional activity from a 200-bp PKD1 proximal promoter in transfected mammalian cells.	Radium	47-49	retinoid X receptor alpha	Homo sapiens	123-126
18922886-1	2008	The retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) and the retinoic acid receptors RAR and RXR significantly induce transcriptional activity from a 200-bp PKD1 proximal promoter in transfected mammalian cells.	Radium	47-49	polycystin 1, transient receptor potential channel interacting	Homo sapiens	187-191
18922886-1	2008	The retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) and the retinoic acid receptors RAR and RXR significantly induce transcriptional activity from a 200-bp PKD1 proximal promoter in transfected mammalian cells.	Radium	79-81	retinoic acid receptor alpha	Homo sapiens	115-118
18922886-1	2008	The retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) and the retinoic acid receptors RAR and RXR significantly induce transcriptional activity from a 200-bp PKD1 proximal promoter in transfected mammalian cells.	Radium	79-81	polycystin 1, transient receptor potential channel interacting	Homo sapiens	187-191
18922886-9	2008	RT-PCR showed that AT-RA treatment of HEK293T cells increased the levels of endogenous PKD1 RNA, and chromatin immunoprecipitation showed the presence of both RXR and Sp1 at the PKD1 proximal promoter.	Radium	22-24	polycystin 1, transient receptor potential channel interacting	Homo sapiens	87-91
18922886-9	2008	RT-PCR showed that AT-RA treatment of HEK293T cells increased the levels of endogenous PKD1 RNA, and chromatin immunoprecipitation showed the presence of both RXR and Sp1 at the PKD1 proximal promoter.	Radium	22-24	polycystin 1, transient receptor potential channel interacting	Homo sapiens	178-182
18835879-3	2008	Previously, we identified two three-marker haplotypes in a 106-kb region in the MHC class III region immediately centromeric to TNF, which are strongly associated with RA on HLA-DRB1*0404 haplotypes.	Radium	168-170	major histocompatibility complex, class II, DR beta 1	Homo sapiens	174-182
18835879-8	2008	RESULTS: Association was observed between RA and single markers or two marker haplotypes involving AIF1, BAT3 and CSNK.	Radium	42-44	allograft inflammatory factor 1	Homo sapiens	99-103
18835879-8	2008	RESULTS: Association was observed between RA and single markers or two marker haplotypes involving AIF1, BAT3 and CSNK.	Radium	42-44	BAG cochaperone 6	Homo sapiens	105-109
18835879-8	2008	RESULTS: Association was observed between RA and single markers or two marker haplotypes involving AIF1, BAT3 and CSNK.	Radium	42-44	casein kappa	Homo sapiens	114-118
18838388-6	2008	RESULTS: The IL-1B (-1464 C/G) G allele was found to be less common in the RA group [P = 0.01; odds ratio (OR) 1.24; 95% CI 1.04, 1.48].	Radium	75-77	interleukin 1 beta	Homo sapiens	13-18
18565102-5	2008	Morphologic and expression analysis demonstrated that 10(-7) M RA applied at d1-5 was most effective to induce the atrial sublineage.	Radium	63-65	leiomodin 1	Homo sapiens	77-81
18838388-9	2008	CONCLUSIONS: There may be a protective effect in RA from the IL-1B (-1464 C/G) G variant.	Radium	49-51	interleukin 1 beta	Homo sapiens	61-66
18838388-11	2008	Further meta-analysis revealed IL-1B (-511 A/G) to be associated with increased susceptibility to RA.	Radium	98-100	interleukin 1 beta	Homo sapiens	31-36
18757243-7	2008	Severe RA stage was associated with highly elevated TL1A and DcR3 serum levels.	Radium	7-9	TNF superfamily member 15	Homo sapiens	52-56
18757243-7	2008	Severe RA stage was associated with highly elevated TL1A and DcR3 serum levels.	Radium	7-9	TNF receptor superfamily member 6b	Homo sapiens	61-65
18835331-9	2008	In summary, we have characterized the zebra finch ortholog of FMRP and found elevated levels in the premotor nucleus RA at a key developmental stage for vocal learning.	Radium	117-119	fragile X messenger ribonucleoprotein 1	Homo sapiens	62-66
18565102-7	2008	Conversely, RA exposure at an early developmental stage inhibited ventricular-specific MLC-2v gene expression.	Radium	12-14	myosin light chain 2	Homo sapiens	87-93
18565102-9	2008	Terminally differentiated cardiomyocytes exposed to RA at d1-5 or d6-10 displayed unchanged I(Ca,L) and I(to) channel expression compared with untreated cells.	Radium	52-54	leiomodin 1	Homo sapiens	58-62
18720532-7	2008	This review introduces the important role of PAF-RA in the treatment of AP.	Radium	49-51	PCNA clamp associated factor	Homo sapiens	45-48
18280134-3	2008	All-transretinoic acid (RA), an active metabolite of vitamin A, regulates the activity of several metabolic enzymes related to OAT, including ornithine decarboxylase and arginase, which may influence the function of OAT through effects on substrate (ornithine) availability.	Radium	24-26	ornithine aminotransferase	Homo sapiens	127-130
18280134-3	2008	All-transretinoic acid (RA), an active metabolite of vitamin A, regulates the activity of several metabolic enzymes related to OAT, including ornithine decarboxylase and arginase, which may influence the function of OAT through effects on substrate (ornithine) availability.	Radium	24-26	ornithine decarboxylase 1	Homo sapiens	142-165
18280134-3	2008	All-transretinoic acid (RA), an active metabolite of vitamin A, regulates the activity of several metabolic enzymes related to OAT, including ornithine decarboxylase and arginase, which may influence the function of OAT through effects on substrate (ornithine) availability.	Radium	24-26	ornithine aminotransferase	Homo sapiens	216-219
18280134-6	2008	Treatment with RA induced increases in OAT gene expression and enzymatic activity, which resulted in decreased intracellular concentrations of ornithine and polyamines (putrescine, spermidine and spermine) in a dose-dependent manner.	Radium	15-17	ornithine aminotransferase	Homo sapiens	39-42
18280134-9	2008	We conclude that exposure of Caco-2 cells to RA induces OAT expression for increasing ornithine catabolism.	Radium	45-47	ornithine aminotransferase	Homo sapiens	56-59
18816852-3	2008	These have shown local control of synthesis and degradation, and computational models suggest that degradation by the Cyp26 enzymes plays a critical role in the formation of a morphogen gradient as well as its ability to compensate for fluctuations in RA levels.	Radium	252-254	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	118-123
18562462-6	2008	The total sample size allows detection of a potential association between RA susceptibility and MBL groups with an odds ratio of 1.37 (alpha &lt; 0.05; 1-beta &gt; 0.8).	Radium	74-76	mannose binding lectin 2	Homo sapiens	96-99
18486601-7	2008	Our present results suggest that a Ras GTPase(s) activated by tyrosine-phosphorylation signals interacts with the inhibitory RA domain, resulting in an active conformation of RIN3 as a Rab5-GEF and that RIN-unique RH domain constitutes a Rab5-binding region for the progress of GEF action.	Radium	125-127	Ras and Rab interactor 3	Homo sapiens	175-179
18474417-3	2008	In this work, we reported that RA treatment for 24 h decreases cell viability, induces apoptosis dependent on caspase-3 activation, and activates the transcription factor AP-1 in cultured Sertoli cells.	Radium	31-33	caspase 3	Homo sapiens	110-119
18474417-3	2008	In this work, we reported that RA treatment for 24 h decreases cell viability, induces apoptosis dependent on caspase-3 activation, and activates the transcription factor AP-1 in cultured Sertoli cells.	Radium	31-33	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-175
18474417-4	2008	Moreover, RA induced a rapid and non-classical stimulation of ERK1/2.	Radium	10-12	mitogen-activated protein kinase 3	Homo sapiens	62-68
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	mitogen-activated protein kinase kinase 1	Homo sapiens	73-79
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	mitogen-activated protein kinase 3	Homo sapiens	80-86
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	caspase 3	Homo sapiens	104-113
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	caspase 3	Homo sapiens	129-138
18486601-7	2008	Our present results suggest that a Ras GTPase(s) activated by tyrosine-phosphorylation signals interacts with the inhibitory RA domain, resulting in an active conformation of RIN3 as a Rab5-GEF and that RIN-unique RH domain constitutes a Rab5-binding region for the progress of GEF action.	Radium	125-127	RAB5A, member RAS oncogene family	Homo sapiens	185-189
18486601-7	2008	Our present results suggest that a Ras GTPase(s) activated by tyrosine-phosphorylation signals interacts with the inhibitory RA domain, resulting in an active conformation of RIN3 as a Rab5-GEF and that RIN-unique RH domain constitutes a Rab5-binding region for the progress of GEF action.	Radium	125-127	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	190-193
18486601-7	2008	Our present results suggest that a Ras GTPase(s) activated by tyrosine-phosphorylation signals interacts with the inhibitory RA domain, resulting in an active conformation of RIN3 as a Rab5-GEF and that RIN-unique RH domain constitutes a Rab5-binding region for the progress of GEF action.	Radium	125-127	RAB5A, member RAS oncogene family	Homo sapiens	238-242
18486601-7	2008	Our present results suggest that a Ras GTPase(s) activated by tyrosine-phosphorylation signals interacts with the inhibitory RA domain, resulting in an active conformation of RIN3 as a Rab5-GEF and that RIN-unique RH domain constitutes a Rab5-binding region for the progress of GEF action.	Radium	125-127	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	278-281
18606996-8	2008	These extracts contained retinoids (5.4 nM) as assessed by RA-inducible Cyp26A1-promoter luciferase reporter cell lines.	Radium	59-61	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	72-79
18799094-1	2008	OBJECTIVE: To test whether the presence of RA associated HLA-DRB1*0101, HLA-DRB1*0401 and HLA-DRB1*0404 alleles individually influences anti-cyclic citrullinated peptide antibodies (anti-CCP) production.	Radium	43-45	major histocompatibility complex, class II, DR beta 1	Homo sapiens	57-65
18492826-5	2008	Using 3T3-F442A adipocytes, we demonstrated that Pck1 expression was 10-fold more sensitive to 9-cis RA (EC(50): 10 nmol/L) than to all-trans RA.	Radium	101-103	phosphoenolpyruvate carboxykinase 1	Homo sapiens	49-53
18492826-5	2008	Using 3T3-F442A adipocytes, we demonstrated that Pck1 expression was 10-fold more sensitive to 9-cis RA (EC(50): 10 nmol/L) than to all-trans RA.	Radium	142-144	phosphoenolpyruvate carboxykinase 1	Homo sapiens	49-53
18492826-6	2008	We then analyzed the respective involvement of RARE1/PCK1, RARE2, and RARE3/PCK2 in the response of Pck1 to 9-cis RA and all-trans RA in adipocytes.	Radium	47-49	phosphoenolpyruvate carboxykinase 1	Homo sapiens	100-104
18492826-7	2008	The response to 9-cis RA mainly involved the RARE1/PCK1 element, whereas RARE2 was mainly responsive to all-trans RA.	Radium	22-24	phosphoenolpyruvate carboxykinase 1	Homo sapiens	51-55
18492826-8	2008	In contrast, the full response to both RA isomers involved these 2 elements and included RARE3/PCK2 as well.	Radium	39-41	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	95-99
18492826-9	2008	Furthermore, 9-cis RA, but not all-trans RA, selectively induced PCK1 in ex-vivo-treated human adipose tissue explants, with a concomitant induction of glyceroneogenesis monitored by [1-(14)C]-pyruvate incorporation into neutral lipids.	Radium	19-21	phosphoenolpyruvate carboxykinase 1	Homo sapiens	65-69
18492826-10	2008	The concomitant 9-cis RA-induced reduction in fatty acid output indicates an important role for this RA stereoisomer in lipid homeostasis through stimulation of PEPCK-C and glyceroneogenesis in adipose tissue.	Radium	22-24	phosphoenolpyruvate carboxykinase 1	Homo sapiens	161-168
18492826-10	2008	The concomitant 9-cis RA-induced reduction in fatty acid output indicates an important role for this RA stereoisomer in lipid homeostasis through stimulation of PEPCK-C and glyceroneogenesis in adipose tissue.	Radium	101-103	phosphoenolpyruvate carboxykinase 1	Homo sapiens	161-168