PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9914520-6	1999	However, the AEAT activity was increased about sixfold by the addition of 250 microm bis-(4-nitrophenyl) phosphate (a serine esterase inhibitor) to the incubation whereas FAEE synthase activity was completely inhibited.	bis(4-nitrophenyl)phosphate	85-114	carboxylesterase 1D	Rattus norvegicus	171-184
10540391-1	1999	Streptomyces dizinc aminopeptidase (sAP) shows a specific activity of 33.7 nmol min(-1) mg(-1) toward the hydrolysis of the transition-state analogue bis-p-nitrophenylphosphate with a rate constant of k(cat)/K(m)=100 M(-1) s(-1) and a first-order rate enhancement of about 10(10), which is much superior to several Zn chemical models and comparable to some phosphodiesterases.	bis(4-nitrophenyl)phosphate	150-176	carboxypeptidase Q	Homo sapiens	20-34
11670819-14	1998	On the basis of (31)P NMR and visible spectra, 2 is shown to hydrolyze tris(p-nitorophenyl) phosphate (TNP) into bis(p-nitrophenyl) phosphate (BNP) in DMSO.	bis(4-nitrophenyl)phosphate	113-141	natriuretic peptide B	Homo sapiens	143-146
2360207-6	1990	Aminooxyacetic acid, an inhibitor of cysteine conjugate beta-lyase, and bis-p-nitrophenyl phosphate, an amidase inhibitor, blocked the effect of N-acetyl PCBC on glutathione reductase, indicating that metabolism by the cytosol is required to produce enzyme inhibition.	bis(4-nitrophenyl)phosphate	72-99	glutathione-disulfide reductase	Rattus norvegicus	162-183
8824203-6	1996	The most catalytically efficient substrate identified was bis-(p-nitrophenyl) phosphate with a Km of 0.9 mM and a kcat of 6.2 x 10(2) min-1, suggesting that the enzyme may also function in vivo as a phosphodiesterase.	bis(4-nitrophenyl)phosphate	58-87	CD59 molecule (CD59 blood group)	Homo sapiens	134-139
9490062-8	1998	Porcine REH was effectively inhibited by alpha-tocopherol and bis-(4-nitrophenyl) phosphate [(Np)2P].	bis(4-nitrophenyl)phosphate	62-91	liver carboxylesterase	Sus scrofa	8-11
11669912-8	1997	The hydrolysis rate of bis(p-nitrophenyl) phosphate (BNP) was measured in aqueous solution at 308.1 K in the presence of the L1and L2 zinc complexes.	bis(4-nitrophenyl)phosphate	23-51	natriuretic peptide B	Homo sapiens	53-56
34904522-2	2022	One of the major in vivo metabolic pathways of vixotrigine in humans is the hydrolysis of the carboxamide to form the carboxylic acid metabolite M14.The in vitro formation of M14 in human hepatocytes was inhibited by the carboxylesterase (CES) inhibitor Bis(4-nitrophenyl) phosphate in a concentration-dependent manner.	bis(4-nitrophenyl)phosphate	254-282	carboxylesterase 1	Homo sapiens	221-237
34933885-7	2022	The findings were further supported by a TAF incubation study with the CatA inhibitor telaprevir and the CES1 inhibitor bis-(p-nitrophenyl) phosphate.	bis(4-nitrophenyl)phosphate	120-149	carboxylesterase 1	Homo sapiens	105-109
6626182-11	1983	The cholinesterase enzyme was also composed of 80 000-Mr subunits (i.e. the residual labelling in band I after bis-p-nitrophenyl phosphate treatment).	bis(4-nitrophenyl)phosphate	111-138	butyrylcholinesterase	Homo sapiens	4-18
435507-15	1979	Beef liver lysophospholipase II was rapidly and stoichiometrically inactivated by diisopropylfluorophosphate and bis(p-nitrophenyl) phosphate.	bis(4-nitrophenyl)phosphate	113-141	lysophospholipase 2	Homo sapiens	11-31
6838491-0	1983	Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus).	bis(4-nitrophenyl)phosphate	80-107	esterase A4	Mus musculus	0-11
6838491-0	1983	Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus).	bis(4-nitrophenyl)phosphate	80-107	esterase A4	Mus musculus	13-18
6178187-5	1982	Pretreatment with carboxylesterase inhibitors, triorthocresylphosphate (TOCP) and bis-p-nitrophenylphosphate (BNPP), potentiated the inhibition of brain ChE by leptophos, suggesting that ISOCase might take a role in leptophos detoxification.	bis(4-nitrophenyl)phosphate	82-108	butyrylcholinesterase	Rattus norvegicus	153-156
6178187-5	1982	Pretreatment with carboxylesterase inhibitors, triorthocresylphosphate (TOCP) and bis-p-nitrophenylphosphate (BNPP), potentiated the inhibition of brain ChE by leptophos, suggesting that ISOCase might take a role in leptophos detoxification.	bis(4-nitrophenyl)phosphate	110-114	butyrylcholinesterase	Rattus norvegicus	153-156
27498590-5	2016	The kinetics of bis(4-nitrophenyl) phosphate (BNPP) hydrolysis catalyzed by G1, G2, 1 and 2 were examined at pHs ranging from 7.50 to 10.50 at 308+-0.1K.	bis(4-nitrophenyl)phosphate	16-44	5-hydroxytryptamine receptor 1A	Homo sapiens	80-91
29407485-6	2018	Inhibition studies revealed that the FD hydrolysis was inhibited by bis-p-nitrophenylphosphate, phenylmethanesulfonyl fluoride, and loperamide (specific for CES2), whereas the pNPA and 4-MUA hydrolysis inhibition was limited.	bis(4-nitrophenyl)phosphate	68-94	carboxylesterase 2	Homo sapiens	157-161
27765821-0	2016	Mechanistic insights into the manganese-dependent phosphodiesterase activity of yeast Dbr1 with bis-p-nitrophenylphosphate and branched RNA substrates.	bis(4-nitrophenyl)phosphate	96-122	RNA lariat debranching enzyme	Saccharomyces cerevisiae S288C	86-90
27765821-5	2016	We report that Dbr1 has a vigorous manganese-dependent phosphodiesterase activity with the non-RNA substrate bis-p-nitrophenylphosphate.	bis(4-nitrophenyl)phosphate	109-135	RNA lariat debranching enzyme	Saccharomyces cerevisiae S288C	15-19
203999-4	1977	Also reported previously, the synthetic phosphodiester bis-p-nitrophenyl phosphate (BNPP) but not various phosphomonoesters preserve LIF activity in the presence of the serine esterase inhibitor phenylmethylsulfonyl fluoride (PMSF).	bis(4-nitrophenyl)phosphate	84-88	LIF interleukin 6 family cytokine	Homo sapiens	133-136
322260-5	1977	alpha-N-benzoyl-L-arginine ethylester (BAEE), a typical trypsin substrate, and bis-p-nitrophenyl phosphate (BNPP), a phosphodiester, were the only esters capable of retaining LIF activity in the presence of PMSF.	bis(4-nitrophenyl)phosphate	79-106	LIF interleukin 6 family cytokine	Homo sapiens	175-178
322260-7	1977	Moreover, the protection afforded by BAEE and BNPP was the king that would be anticipated if the esters and irreversible inhibitor competed for the same site on LIF.	bis(4-nitrophenyl)phosphate	46-50	LIF interleukin 6 family cytokine	Homo sapiens	161-164
322260-9	1977	In addition, LIF-treated leukocytes partly escaped migration inhibition in the presence of BAEE and BNPP, respectively.	bis(4-nitrophenyl)phosphate	100-104	LIF interleukin 6 family cytokine	Homo sapiens	13-16
322260-11	1977	It is still not proved, however, that LIF as an enzyme is capable of hydrolyzing BAEE and BNPP, although it seems highly possible.	bis(4-nitrophenyl)phosphate	90-94	LIF interleukin 6 family cytokine	Homo sapiens	38-41
322260-12	1977	The substrate specificities of a putative LIF enzyme are discussed on the basis of the chemical structure of BAEE and BNPP.	bis(4-nitrophenyl)phosphate	118-122	LIF interleukin 6 family cytokine	Homo sapiens	42-45
27498590-5	2016	The kinetics of bis(4-nitrophenyl) phosphate (BNPP) hydrolysis catalyzed by G1, G2, 1 and 2 were examined at pHs ranging from 7.50 to 10.50 at 308+-0.1K.	bis(4-nitrophenyl)phosphate	46-50	5-hydroxytryptamine receptor 1A	Homo sapiens	80-91
26817948-7	2016	Moreover, sacubitril activation was significantly inhibited by the carboxylesterase 1 (CES1) inhibitor bis-(p-nitrophenyl) phosphate in human liver S9.	bis(4-nitrophenyl)phosphate	103-132	carboxylesterase 1	Homo sapiens	67-85
26817948-7	2016	Moreover, sacubitril activation was significantly inhibited by the carboxylesterase 1 (CES1) inhibitor bis-(p-nitrophenyl) phosphate in human liver S9.	bis(4-nitrophenyl)phosphate	103-132	carboxylesterase 1	Homo sapiens	87-91
24752820-1	2014	Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.	bis(4-nitrophenyl)phosphate	229-256	C-C motif chemokine ligand 4	Homo sapiens	69-73
23530020-7	2013	Incubation with diisopropyl fluorophosphate and bis-(4-nitrophenyl) phosphate, which are general inhibitors of CES, significantly decreased Met-Hb formation when prilocaine and lidocaine were incubated with HLM.	bis(4-nitrophenyl)phosphate	48-77	hemoglobin subunit gamma 2	Homo sapiens	140-146
24212377-5	2014	The impact of CES1-mediated BIBR 1087 formation during transcellular transport experiments was assessed by comparing several combinations of three experimental approaches: radioactivity detection using [(14)C]dabigatran etexilate as substrate, liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantification of dabigatran etexilate, and in the presence and absence of a CES inhibitor bis(p-nitrophenyl) phosphate (BNPP).	bis(4-nitrophenyl)phosphate	393-421	carboxylesterase 1	Homo sapiens	14-18
24212377-5	2014	The impact of CES1-mediated BIBR 1087 formation during transcellular transport experiments was assessed by comparing several combinations of three experimental approaches: radioactivity detection using [(14)C]dabigatran etexilate as substrate, liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantification of dabigatran etexilate, and in the presence and absence of a CES inhibitor bis(p-nitrophenyl) phosphate (BNPP).	bis(4-nitrophenyl)phosphate	423-427	carboxylesterase 1	Homo sapiens	14-18
23275066-5	2013	Coincubation of clopidogrel with the CES1 inhibitor bis(4-nitrophenyl) phosphate in human liver s9 fractions significantly increased the concentrations of clopidogrel, 2-oxo-clopidogrel, and clopidogrel active metabolite, while the concentrations of all formed carboxylate metabolites were significantly decreased.	bis(4-nitrophenyl)phosphate	52-80	carboxylesterase 1	Homo sapiens	37-41
15256494-6	2004	In rat serum, the carboxylesterase inhibitor bis-p-nitrophenyl-phosphate totally inhibited ghrelin desoctanoylation, and a correlation was found between ghrelin desoctanoylation and carboxylesterase activity.	bis(4-nitrophenyl)phosphate	45-72	ghrelin and obestatin prepropeptide	Rattus norvegicus	91-98
22085648-6	2012	Benzil and bis-p-nitrophenyl phosphate (BNPP), two carboxylesterase inhibitors, abrogated the effect of carboxylesterases and resensitized carboxylesterase-expressing cells to the potent cytotoxic effects of phospho-NSAIDs.	bis(4-nitrophenyl)phosphate	11-38	carboxylesterase 1	Homo sapiens	104-121
22085648-6	2012	Benzil and bis-p-nitrophenyl phosphate (BNPP), two carboxylesterase inhibitors, abrogated the effect of carboxylesterases and resensitized carboxylesterase-expressing cells to the potent cytotoxic effects of phospho-NSAIDs.	bis(4-nitrophenyl)phosphate	40-44	carboxylesterase 1	Homo sapiens	104-121
21865160-4	2011	Enzymatic assays showed that, in addition to phosphodiesterase activity for bis(p-nitrophenyl) phosphate, Spr1479 has hydrolase activity for diadenosine polyphosphate (Ap(n)A) and ATP.	bis(4-nitrophenyl)phosphate	76-104	spr1479	Streptococcus pneumoniae R6	106-113
21504219-2	2011	The copper(II) complexes of these ligands are able to accelerate cleavage of the P-O bonds within the model phosphodiesters bis(p-nitrophenyl)phosphate (BNPP) and [2-(hydroxypropyl)-p-nitrophenyl]phosphate (HPNPP), as well as supercoiled pBR 322 plasmid DNA.	bis(4-nitrophenyl)phosphate	124-151	translocator protein	Homo sapiens	238-241
21504219-2	2011	The copper(II) complexes of these ligands are able to accelerate cleavage of the P-O bonds within the model phosphodiesters bis(p-nitrophenyl)phosphate (BNPP) and [2-(hydroxypropyl)-p-nitrophenyl]phosphate (HPNPP), as well as supercoiled pBR 322 plasmid DNA.	bis(4-nitrophenyl)phosphate	153-157	translocator protein	Homo sapiens	238-241
21207966-2	2011	Taking the advantage of loperamide, a specific carboxylesterase 2 (CES2) inhibitor, and bis-p-nitrophenyl phosphate (BNPP), an irreversible CESs inhibitor, we propose for the first time a capillary electrophoresis (CE) method that enables detecting and distinguishing CES2 activity from other CESs in complex biological samples.	bis(4-nitrophenyl)phosphate	117-121	carboxylesterase 2	Homo sapiens	268-272
20947616-6	2011	In animal and human liver S9, this metabolic pathway could be inhibited by 4-methylpyrazole, bis-p-nitrophenylphosphate (BNPP), or a brief heat treatment at 50 C. Based on these results, the overall metabolic pathway was believed to involve a two-step oxidation process: dehydrogenation of the secondary alcohol in liver cytosol followed by an FMO5-mediated Baeyer-Villiger oxidation in liver microsomes.	bis(4-nitrophenyl)phosphate	93-119	flavin containing dimethylaniline monoxygenase 5	Homo sapiens	344-348
20947616-6	2011	In animal and human liver S9, this metabolic pathway could be inhibited by 4-methylpyrazole, bis-p-nitrophenylphosphate (BNPP), or a brief heat treatment at 50 C. Based on these results, the overall metabolic pathway was believed to involve a two-step oxidation process: dehydrogenation of the secondary alcohol in liver cytosol followed by an FMO5-mediated Baeyer-Villiger oxidation in liver microsomes.	bis(4-nitrophenyl)phosphate	121-125	flavin containing dimethylaniline monoxygenase 5	Homo sapiens	344-348
18606399-4	2008	The addition of the carboxylesterase inhibitor bis-(4-nitrophenyl) phosphate (BNPP) inhibited the degradation of the novel drug, indicating that it may be a substrate for both butyrylcholinesterase and carboxylesterase.	bis(4-nitrophenyl)phosphate	47-76	butyrylcholinesterase	Mus musculus	176-218
18606399-4	2008	The addition of the carboxylesterase inhibitor bis-(4-nitrophenyl) phosphate (BNPP) inhibited the degradation of the novel drug, indicating that it may be a substrate for both butyrylcholinesterase and carboxylesterase.	bis(4-nitrophenyl)phosphate	78-82	butyrylcholinesterase	Mus musculus	176-218
22294686-9	2012	The AcMPAG deglucuronidation by recombinant ABHD10, HLC, and HLH were potently inhibited by AgNO(3), CdCl(2), CuCl(2), PMSF, bis-p-nitrophenylphosphate, and DTNB.	bis(4-nitrophenyl)phosphate	125-151	abhydrolase domain containing 10, depalmitoylase	Homo sapiens	44-50
20297923-0	2010	Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.	bis(4-nitrophenyl)phosphate	73-77	G protein-coupled bile acid receptor 1	Rattus norvegicus	190-194
16147995-6	2005	Phosphodiesterase activity of tissue nonspecific alkaline phosphatase for bis-p-nitrophenyl phosphate was confirmed, the rate of this phosphodiesterase activity is in the same range as that of phosphomonoesterase activity for p-nitrophenyl phosphate under physiological pH.	bis(4-nitrophenyl)phosphate	74-101	alkaline phosphatase, liver/bone/kidney	Gallus gallus	30-69
12883081-12	2003	Bis(p-nitrophenyl)phosphate (BNPP), a carboxylesterase inhibitor, was able to attenuate the vinyl acetate-induced decrease in pHi.	bis(4-nitrophenyl)phosphate	0-27	glucose-6-phosphate isomerase	Rattus norvegicus	126-129
12883081-12	2003	Bis(p-nitrophenyl)phosphate (BNPP), a carboxylesterase inhibitor, was able to attenuate the vinyl acetate-induced decrease in pHi.	bis(4-nitrophenyl)phosphate	29-33	glucose-6-phosphate isomerase	Rattus norvegicus	126-129
11896299-9	2002	The effect of vinyl acetate on pH(i) was attenuated by prior exposure to the carboxylesterase inhibitor bis(p-nitrophenyl)phosphate.	bis(4-nitrophenyl)phosphate	104-131	glucose-6-phosphate isomerase	Homo sapiens	31-36
11341928-2	2001	It has been shown that the salt effect on the reaction of acetylcholinesterase with anionic bis(p-nitrophenyl) phosphate is determined by the influence of added salts on the activity coefficient of the inhibitor.	bis(4-nitrophenyl)phosphate	92-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-78