PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27170440-7	2016	CHD1 mRNA level was partially decreased in response to alpha-amanitin (RNA polymerase II inhibitor) treatment, suggesting that CHD1 mRNA in eight-cell embryos is of both maternal and zygotic origin.	Alpha-Amanitin	55-69	chromodomain helicase DNA binding protein 1	Bos taurus	0-4
28292928-2	2017	Assembly of the Elongin A ubiquitin ligase and its recruitment to sites of DNA damage is a tightly regulated process induced by DNA-damaging agents and alpha-amanitin, a drug that induces Pol II stalling.	Alpha-Amanitin	152-166	elongin A	Homo sapiens	16-25
27035356-5	2017	MCPIP1 expression induced by MG132 was inhibited by alpha-amanitin inhibition of gene transcription or cycloheximide inhibition of protein synthesis.	Alpha-Amanitin	52-66	zinc finger CCCH-type containing 12A	Homo sapiens	0-6
28241077-5	2017	Instead, we identified Megalin, Tequila, and widerborst as candidate genes underlying the alpha-amanitin resistance phenotype in the North American DGRP lines, all three of which are connected to the Target of Rapamycin (TOR) pathway.	Alpha-Amanitin	90-104	Megalin	Drosophila melanogaster	23-30
28241077-5	2017	Instead, we identified Megalin, Tequila, and widerborst as candidate genes underlying the alpha-amanitin resistance phenotype in the North American DGRP lines, all three of which are connected to the Target of Rapamycin (TOR) pathway.	Alpha-Amanitin	90-104	Tequila	Drosophila melanogaster	32-39
28241077-5	2017	Instead, we identified Megalin, Tequila, and widerborst as candidate genes underlying the alpha-amanitin resistance phenotype in the North American DGRP lines, all three of which are connected to the Target of Rapamycin (TOR) pathway.	Alpha-Amanitin	90-104	Target of rapamycin	Drosophila melanogaster	200-219
28241077-5	2017	Instead, we identified Megalin, Tequila, and widerborst as candidate genes underlying the alpha-amanitin resistance phenotype in the North American DGRP lines, all three of which are connected to the Target of Rapamycin (TOR) pathway.	Alpha-Amanitin	90-104	Target of rapamycin	Drosophila melanogaster	221-224
27226557-4	2016	We find that the mushroom toxin alpha-amanitin, which inhibits TL mobility, suppresses the effect of Rpb9 on NTP misincorporation, consistent with a role for Rpb9 in this process.	Alpha-Amanitin	32-46	DNA-directed RNA polymerase II core subunit RPB9	Saccharomyces cerevisiae S288C	101-105
27226557-4	2016	We find that the mushroom toxin alpha-amanitin, which inhibits TL mobility, suppresses the effect of Rpb9 on NTP misincorporation, consistent with a role for Rpb9 in this process.	Alpha-Amanitin	32-46	DNA-directed RNA polymerase II core subunit RPB9	Saccharomyces cerevisiae S288C	158-162
27170440-7	2016	CHD1 mRNA level was partially decreased in response to alpha-amanitin (RNA polymerase II inhibitor) treatment, suggesting that CHD1 mRNA in eight-cell embryos is of both maternal and zygotic origin.	Alpha-Amanitin	55-69	chromodomain helicase DNA binding protein 1	Bos taurus	127-131
25901683-8	2015	Suppression of POLR2A with alpha-amanitin or small interfering RNAs selectively inhibits the proliferation, survival and tumorigenic potential of colorectal cancer cells with hemizygous TP53 loss in a p53-independent manner.	Alpha-Amanitin	27-41	RNA polymerase II subunit A	Homo sapiens	15-21
27140624-8	2016	In addition, alpha-amanitin-insensitive vegt transcripts were detected around vegetal nuclei of the blastula.	Alpha-Amanitin	13-27	vegt protein S homeolog	Xenopus laevis	40-44
27181033-0	2016	alpha-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15.	Alpha-Amanitin	0-14	TATA-box binding protein associated factor 15	Mus musculus	83-88
27181033-4	2016	We consistently found that alpha-amanitin, an RNA polymerase II (RNAPII) inhibitor, effectively inhibited DTCs by suppressing TAF15 expression, which binds to RNA to modulate transcription and RNA processing.	Alpha-Amanitin	27-41	TATA-box binding protein associated factor 15	Mus musculus	126-131
27181033-6	2016	Therefore, post-treatment cancer relapse may occur through non-distinct subpopulations and may be effectively prevented by alpha-amanitin to disrupt transcriptional machinery, including TAF15.	Alpha-Amanitin	123-137	TATA-box binding protein associated factor 15	Mus musculus	186-191
25901683-11	2015	Here we show that low doses of alpha-amanitin-conjugated anti-epithelial cell adhesion molecule (EpCAM) antibody lead to complete tumour regression in mouse models of human colorectal cancer with hemizygous deletion of POLR2A.	Alpha-Amanitin	31-45	epithelial cell adhesion molecule	Mus musculus	97-102
25901683-11	2015	Here we show that low doses of alpha-amanitin-conjugated anti-epithelial cell adhesion molecule (EpCAM) antibody lead to complete tumour regression in mouse models of human colorectal cancer with hemizygous deletion of POLR2A.	Alpha-Amanitin	31-45	RNA polymerase II subunit A	Homo sapiens	219-225
23667685-7	2013	We present data demonstrating that URI nuclear/cytoplasmic shuttling is affected by compounds that stall pol II on the DNA (alpha-amanitin and actinomycin-D) and by leptomycin B, an inhibitor of the CRM1 exportin that mediates the nuclear export of pol II subunits.	Alpha-Amanitin	124-138	URI1 prefoldin like chaperone	Homo sapiens	35-38
22491901-8	2012	To see if this increase was due to minor transcriptional activity, 2-cell embryos were exposed to alpha-amanitin for 30-34 h. Results showed a significant decrease in miR-21, pre-miR-21, miR-130a and SRFS3 in alpha-amanitin-treated embryos (P < 0.05).	Alpha-Amanitin	98-112	microRNA 21	Bos taurus	167-173
22524704-13	2012	Upcyte( ) hepatocytes were markedly more sensitive to the hepatotoxin, alpha-amanitin, than HepG2 cells, indicating functional OATP1B3 uptake.	Alpha-Amanitin	71-85	solute carrier organic anion transporter family member 1B3	Homo sapiens	127-134
25949122-7	2013	Expression of genes for cumulus expansion markers (Ptx3, Has2, and Tnfaip6) and gap junctional proteins (Gja1, Gja4, and Gjc1) decreased in alpha-amanitin-treated CCs.	Alpha-Amanitin	140-154	pentraxin related gene	Mus musculus	51-55
25949122-7	2013	Expression of genes for cumulus expansion markers (Ptx3, Has2, and Tnfaip6) and gap junctional proteins (Gja1, Gja4, and Gjc1) decreased in alpha-amanitin-treated CCs.	Alpha-Amanitin	140-154	hyaluronan synthase 2	Mus musculus	57-61
25949122-7	2013	Expression of genes for cumulus expansion markers (Ptx3, Has2, and Tnfaip6) and gap junctional proteins (Gja1, Gja4, and Gjc1) decreased in alpha-amanitin-treated CCs.	Alpha-Amanitin	140-154	tumor necrosis factor alpha induced protein 6	Mus musculus	67-74
25949122-7	2013	Expression of genes for cumulus expansion markers (Ptx3, Has2, and Tnfaip6) and gap junctional proteins (Gja1, Gja4, and Gjc1) decreased in alpha-amanitin-treated CCs.	Alpha-Amanitin	140-154	gap junction protein, alpha 1	Mus musculus	105-109
25949122-7	2013	Expression of genes for cumulus expansion markers (Ptx3, Has2, and Tnfaip6) and gap junctional proteins (Gja1, Gja4, and Gjc1) decreased in alpha-amanitin-treated CCs.	Alpha-Amanitin	140-154	gap junction protein, alpha 4	Mus musculus	111-115
25949122-7	2013	Expression of genes for cumulus expansion markers (Ptx3, Has2, and Tnfaip6) and gap junctional proteins (Gja1, Gja4, and Gjc1) decreased in alpha-amanitin-treated CCs.	Alpha-Amanitin	140-154	gap junction protein, gamma 1	Mus musculus	121-125
25949122-9	2013	In addition, expression of genes related to metabolism (Prps1, Rpe, Rpia, Taldo1, and Tkt) decreased in alpha -amanitin-treated CCs but not in oocytes.	Alpha-Amanitin	104-119	phosphoribosyl pyrophosphate synthetase 1	Mus musculus	56-61
25949122-9	2013	In addition, expression of genes related to metabolism (Prps1, Rpe, Rpia, Taldo1, and Tkt) decreased in alpha -amanitin-treated CCs but not in oocytes.	Alpha-Amanitin	104-119	ribulose-5-phosphate-3-epimerase	Mus musculus	63-66
25949122-9	2013	In addition, expression of genes related to metabolism (Prps1, Rpe, Rpia, Taldo1, and Tkt) decreased in alpha -amanitin-treated CCs but not in oocytes.	Alpha-Amanitin	104-119	ribose 5-phosphate isomerase A	Mus musculus	68-72
25949122-9	2013	In addition, expression of genes related to metabolism (Prps1, Rpe, Rpia, Taldo1, and Tkt) decreased in alpha -amanitin-treated CCs but not in oocytes.	Alpha-Amanitin	104-119	transaldolase 1	Mus musculus	74-80
25949122-9	2013	In addition, expression of genes related to metabolism (Prps1, Rpe, Rpia, Taldo1, and Tkt) decreased in alpha -amanitin-treated CCs but not in oocytes.	Alpha-Amanitin	104-119	transketolase	Mus musculus	86-89
23247044-7	2013	CAT activity for alpha-amanitin doses 0.1 and 0.15 mg/kg was higher in comparison to the negative control but the differences were not statistically significant (p > 0.05).	Alpha-Amanitin	17-31	catalase	Mus musculus	0-3
24738249-3	2013	Alpha-amanitin, the RNA-polymerize II repressor, in toxic doze, could induce the chromosome transference in the cells from all studied groups: from old and young donors and donors with repair process defect (with BRCA 1, 2 mutations).	Alpha-Amanitin	0-14	BRCA1 DNA repair associated	Homo sapiens	213-219
22491901-8	2012	To see if this increase was due to minor transcriptional activity, 2-cell embryos were exposed to alpha-amanitin for 30-34 h. Results showed a significant decrease in miR-21, pre-miR-21, miR-130a and SRFS3 in alpha-amanitin-treated embryos (P < 0.05).	Alpha-Amanitin	98-112	microRNA 21	Bos taurus	179-185
22491901-8	2012	To see if this increase was due to minor transcriptional activity, 2-cell embryos were exposed to alpha-amanitin for 30-34 h. Results showed a significant decrease in miR-21, pre-miR-21, miR-130a and SRFS3 in alpha-amanitin-treated embryos (P < 0.05).	Alpha-Amanitin	98-112	microRNA 130a	Bos taurus	187-195
22645362-5	2012	I-PpoI-induced contact between homologous genes is abrogated by the transcriptional inhibitors actinomycin D and alpha-amanitin and requires the kinase activity of ATM but not DNA-PK.	Alpha-Amanitin	113-127	ATM serine/threonine kinase	Homo sapiens	164-167
22457476-12	2012	CONCLUSION: This preclinical study suggests that anti-EpCAM antibody conjugates with alpha-amanitin have the potential to be highly effective therapeutic agents for pancreatic carcinomas and various EpCAM-expressing malignancies.	Alpha-Amanitin	85-99	epithelial cell adhesion molecule	Mus musculus	54-59
22350759-7	2012	Treatment of the SNU-719 EBV-positive gastric cancer cell line with alpha-amanitin at a concentration that selectively inhibits RNA polymerase II activity decreased the expression levels of BART miRNAs.	Alpha-Amanitin	68-82	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	190-194
22457476-12	2012	CONCLUSION: This preclinical study suggests that anti-EpCAM antibody conjugates with alpha-amanitin have the potential to be highly effective therapeutic agents for pancreatic carcinomas and various EpCAM-expressing malignancies.	Alpha-Amanitin	85-99	epithelial cell adhesion molecule	Mus musculus	199-204
20811013-3	2011	Steady-state concentrations of mRNA for the antiapoptotic genes BCL2 and HSPA1A were higher for MII oocytes, 2-cell embryos, and 2-cell embryos treated with alpha-amanitin as compared to >=16-cell embryos.	Alpha-Amanitin	157-171	BCL2 apoptosis regulator	Bos taurus	64-68
22217779-3	2011	For eight tolerant and one related susceptible species, we sequenced the gene encoding the large subunit of RNA Polymerase II, which is the target site of alpha-amanitin.	Alpha-Amanitin	155-169	RNA polymerase II 215kD subunit	Drosophila melanogaster	108-125
22194310-2	2012	Mutations of interest are introduced into an alpha-amanitin-resistant version of Rpb1, which is then expressed ectopically in cells.	Alpha-Amanitin	45-59	RNA polymerase II subunit A	Homo sapiens	81-85
22194310-4	2012	Here, we show that cells that are enabled to grow in alpha-amanitin by expression of an alpha-amanitin-resistant Rpb1 exhibit changes in cell physiology that can lead to misleading experimental outcomes.	Alpha-Amanitin	53-67	RNA polymerase II subunit A	Homo sapiens	113-117
22194310-4	2012	Here, we show that cells that are enabled to grow in alpha-amanitin by expression of an alpha-amanitin-resistant Rpb1 exhibit changes in cell physiology that can lead to misleading experimental outcomes.	Alpha-Amanitin	88-102	RNA polymerase II subunit A	Homo sapiens	113-117
22019700-7	2011	The ability of TAF15 to directly contact RNA, most likely RNA pol II transcripts, was supported by in vivo UV cross-linking studies in the presence of alpha-amanitin.	Alpha-Amanitin	151-165	TATA-box binding protein associated factor 15	Homo sapiens	15-20
22384351-0	2011	Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in alpha-Amanitin Resistance and/or Reduced Function.	Alpha-Amanitin	114-128	Ama1p	Saccharomyces cerevisiae S288C	87-92
22384351-1	2011	Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause alpha-amanitin resistance and/or developmental defects were isolated previously.	Alpha-Amanitin	89-103	DNA-directed RNA polymerase II subunit RPB1	Caenorhabditis elegans	58-63
21248291-5	2011	Paf (37 nM) treatment of 2-cell embryos caused an alpha-amanitin (26 muM)-sensitive increase in Bcl2 and Fos transcripts 20 min after treatment that subsided by 40 min.	Alpha-Amanitin	50-64	B cell leukemia/lymphoma 2	Mus musculus	96-100
21248291-5	2011	Paf (37 nM) treatment of 2-cell embryos caused an alpha-amanitin (26 muM)-sensitive increase in Bcl2 and Fos transcripts 20 min after treatment that subsided by 40 min.	Alpha-Amanitin	50-64	FBJ osteosarcoma oncogene	Mus musculus	105-108
20811013-3	2011	Steady-state concentrations of mRNA for the antiapoptotic genes BCL2 and HSPA1A were higher for MII oocytes, 2-cell embryos, and 2-cell embryos treated with alpha-amanitin as compared to >=16-cell embryos.	Alpha-Amanitin	157-171	heat shock 70 kDa protein 1B	Bos taurus	73-79
20422051-6	2010	After alpha-amanitin pre-treatment, the VP16-activator, GCN5, and Brd2 are still recruited to the transcription site but the chromatin does not decondense.	Alpha-Amanitin	6-20	host cell factor C1	Homo sapiens	40-44
20647547-3	2010	At physiological concentrations (1-10 ng/ml), leptin increased LSR protein and mRNA levels in Hepa1-6 cells through an ERK1/2-dependent and alpha-amanitin-sensitive pathway.	Alpha-Amanitin	140-154	leptin	Mus musculus	46-52
20647547-3	2010	At physiological concentrations (1-10 ng/ml), leptin increased LSR protein and mRNA levels in Hepa1-6 cells through an ERK1/2-dependent and alpha-amanitin-sensitive pathway.	Alpha-Amanitin	140-154	lipolysis stimulated lipoprotein receptor	Mus musculus	63-66
20101221-7	2010	GSK-3beta activation was independent of RNA pol II dephosphorylation confirmed by alpha-amanitin, a specific RNA pol II inihibitor, showing potent inhibition of RNA pol II phosphorylation without corresponding effects on GSK-3beta phosphorylation.	Alpha-Amanitin	82-96	glycogen synthase kinase 3 beta	Homo sapiens	0-9
20422051-6	2010	After alpha-amanitin pre-treatment, the VP16-activator, GCN5, and Brd2 are still recruited to the transcription site but the chromatin does not decondense.	Alpha-Amanitin	6-20	lysine acetyltransferase 2A	Homo sapiens	56-60
20422051-6	2010	After alpha-amanitin pre-treatment, the VP16-activator, GCN5, and Brd2 are still recruited to the transcription site but the chromatin does not decondense.	Alpha-Amanitin	6-20	bromodomain containing 2	Homo sapiens	66-70
20175232-0	2010	[Effect of DRB/alpha-Amanitin on localization of Nrf2 in A549 cells].	Alpha-Amanitin	15-29	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
20175232-7	2010	CONCLUSION: DRB and alpha-Amanitin can down-regulate the expression of Nrf2 and its targeting proteins HO-1, AKR1C and NQO1, but may have no effect on the localization of Nrf2.	Alpha-Amanitin	20-34	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
20175232-1	2010	OBJECTIVE: To investigate the effects of transcriptional inhibitors 5, 6-dichloro-1-b-D-ribofuranosylbenzimidazole (DRB) and alpha-Amanitin on the localization of Nrf2 in the nucleus.	Alpha-Amanitin	125-139	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
20175232-7	2010	CONCLUSION: DRB and alpha-Amanitin can down-regulate the expression of Nrf2 and its targeting proteins HO-1, AKR1C and NQO1, but may have no effect on the localization of Nrf2.	Alpha-Amanitin	20-34	heme oxygenase 1	Homo sapiens	103-114
20175232-7	2010	CONCLUSION: DRB and alpha-Amanitin can down-regulate the expression of Nrf2 and its targeting proteins HO-1, AKR1C and NQO1, but may have no effect on the localization of Nrf2.	Alpha-Amanitin	20-34	NAD(P)H quinone dehydrogenase 1	Homo sapiens	119-123
19950610-12	2009	CONCLUSION: Serum BUN, Crea, ALT, AST, TBIL and DBIL are sensitive indicators for the toxicity of alpha-amanitin in vivo.	Alpha-Amanitin	98-112	glutamic pyruvic transaminase, soluble	Mus musculus	29-32
19700751-9	2009	Eventually, the protective effect of orally administered glucose on liver injury induced by LPS, overdose of acetaminophen, or alpha-amanitin was shown to be mediated by the anti-inflammatory cytokine interleukin-10.	Alpha-Amanitin	127-141	interleukin 10	Mus musculus	201-215
19950610-12	2009	CONCLUSION: Serum BUN, Crea, ALT, AST, TBIL and DBIL are sensitive indicators for the toxicity of alpha-amanitin in vivo.	Alpha-Amanitin	98-112	transmembrane protease, serine 11d	Mus musculus	34-37
19398578-4	2009	Treatment of cells overexpressing NF90 and NF45 with an RNA polymerase II inhibitor, alpha-amanitin, did not reduce the amounts of pri-miRNAs, suggesting that the accumulation of pri-miRNAs is not due to transcriptional activation.	Alpha-Amanitin	85-99	interleukin enhancer binding factor 3	Homo sapiens	34-38
19501393-9	2009	The transcription of CENPF and HMGN2 is alpha-amanitin sensitive only at late 8-cell stage and morula, respectively.	Alpha-Amanitin	40-54	centromere protein F	Bos taurus	21-26
19501393-9	2009	The transcription of CENPF and HMGN2 is alpha-amanitin sensitive only at late 8-cell stage and morula, respectively.	Alpha-Amanitin	40-54	high mobility group nucleosomal binding domain 2	Bos taurus	31-36
19398578-4	2009	Treatment of cells overexpressing NF90 and NF45 with an RNA polymerase II inhibitor, alpha-amanitin, did not reduce the amounts of pri-miRNAs, suggesting that the accumulation of pri-miRNAs is not due to transcriptional activation.	Alpha-Amanitin	85-99	interleukin enhancer binding factor 2	Homo sapiens	43-47
19411846-10	2009	Surprisingly, blocking the transcriptional arm of p53, either via alpha-Amanitin or the p53-specific transcriptional inhibitor Pifithrin alpha, not only fails to inhibit, but greatly potentiates Nutlin-induced apoptosis.	Alpha-Amanitin	66-80	tumor protein p53	Homo sapiens	50-53
19353593-9	2009	Inhibition of transcription by alpha-amanitin caused a reduction in CRYM mRNA.	Alpha-Amanitin	31-45	crystallin mu	Homo sapiens	68-72
19341710-5	2009	BMP-2 also reduced miR-206 expression in the presence of alpha-amanitin in a similar manner to that in the absence of alpha-amanitin.	Alpha-Amanitin	57-71	bone morphogenetic protein 2	Mus musculus	0-5
19341710-5	2009	BMP-2 also reduced miR-206 expression in the presence of alpha-amanitin in a similar manner to that in the absence of alpha-amanitin.	Alpha-Amanitin	57-71	microRNA 206	Mus musculus	19-26
19341710-5	2009	BMP-2 also reduced miR-206 expression in the presence of alpha-amanitin in a similar manner to that in the absence of alpha-amanitin.	Alpha-Amanitin	118-132	bone morphogenetic protein 2	Mus musculus	0-5
18621687-5	2008	We show by alpha-amanitin inhibition that RNA polymerase II (RNAPII) transcription is required to localize MCM2-7 (but not ORC) to permit the second round of origin firing.	Alpha-Amanitin	11-25	RNA polymerase II 215kD subunit	Drosophila melanogaster	42-59
18621687-5	2008	We show by alpha-amanitin inhibition that RNA polymerase II (RNAPII) transcription is required to localize MCM2-7 (but not ORC) to permit the second round of origin firing.	Alpha-Amanitin	11-25	RNA polymerase II 215kD subunit	Drosophila melanogaster	61-67
18621687-5	2008	We show by alpha-amanitin inhibition that RNA polymerase II (RNAPII) transcription is required to localize MCM2-7 (but not ORC) to permit the second round of origin firing.	Alpha-Amanitin	11-25	Minichromosome maintenance 2	Drosophila melanogaster	107-113
16485114-11	2006	This effect on KGFR autophosphorylation was still present when cells were treated with the alpha-amanitin, an inhibitor of RNA transcription, indicating a rapid, nongenomic effect.	Alpha-Amanitin	91-105	fibroblast growth factor receptor 2	Homo sapiens	15-19
17512903-2	2007	Alpha amanitin resistant transcription from Spodoptera litura nucleopolyhedrovirus (SpltNPV-I) polyhedrin promoter was observed with virus infected nuclear extract of NIV-HA-197 cells but not with that from uninfected nuclear extract.	Alpha-Amanitin	0-14	major occlusion protein	Spodoptera litura nucleopolyhedrovirus	95-105
17224908-5	2007	Disruption of transcription by actinomycin D, 5,6-dichloro-1-beta-D-ribofuranosyl-benzimadazole or alpha-amanitin leads to accumulation of cellular p53 protein.	Alpha-Amanitin	99-113	tumor protein p53	Homo sapiens	148-151
17336461-11	2007	This therefore informed the decision to study the in vivo effect of alpha amanitin on SOD and CAT activity and the level of lipid peroxidation (LPO) products in liver homogenates isolated from mice treated with the toxin.	Alpha-Amanitin	68-82	catalase	Mus musculus	94-97
16606619-11	2006	The association of phosphorylated PI4K92 with nuclear speckles is dynamic and follows the morphological alteration of speckles upon inhibition of mRNA transcription with alpha-amanitin.	Alpha-Amanitin	170-184	phosphatidylinositol 4-kinase beta	Homo sapiens	34-40
18289623-7	2008	The RNA synthesis inhibitor alpha-amanitin induced similar to mafosfamide more apoptosis in p53(wt) than in p53(mt) cells.	Alpha-Amanitin	28-42	tumor protein p53	Homo sapiens	92-95
18289623-7	2008	The RNA synthesis inhibitor alpha-amanitin induced similar to mafosfamide more apoptosis in p53(wt) than in p53(mt) cells.	Alpha-Amanitin	28-42	tumor protein p53	Homo sapiens	108-111
18296417-11	2008	Oatp1b2-null mice were completely resistant to the hepatotoxicity induced by phalloidin and microcystin-LR, but were similarly sensitive to alpha-amanitin-induced hepatotoxicity compared with wild-type mice.	Alpha-Amanitin	140-154	solute carrier organic anion transporter family, member 1b2	Mus musculus	0-7
17524367-8	2007	This enrichment was lost when cells were treated with alpha-amanitin showing that DEK binds to this particular site only when the TOP1 gene is actively expressed.	Alpha-Amanitin	54-68	DEK proto-oncogene	Homo sapiens	82-85
17218408-6	2007	The Pde3a mRNA level was up-regulated 28-fold in the COC after 4 h of IVM and remained high up to 12 h. The mRNA up-regulation and increased activity were inhibited by an RNA synthesis inhibitor, alpha-amanitin.	Alpha-Amanitin	196-210	phosphodiesterase 3A	Homo sapiens	4-9
16427078-4	2006	alpha-Amanitin caused an accumulation of RNAPII at transcribed genes, a reduction of TBP bound to chromatin and a less accessible chromatin structure.	Alpha-Amanitin	0-14	TATA-box binding protein	Homo sapiens	85-88
16331601-9	2006	Exposure of ACC cells to cisplatin resulted in upregulation of CXCR4 on the cell surface, which was repressed by the transcriptional inhibitor, alpha-amanitin.	Alpha-Amanitin	144-158	C-X-C motif chemokine receptor 4	Homo sapiens	63-68
15457515-9	2004	The exposure of fertilized oocytes to the RNA polymerase II inhibitor alpha-amanitin was able to suppress this Zar1 increase indicating that transcription of this gene occurs at the 4-cell stage.	Alpha-Amanitin	70-84	zygote arrest 1	Bos taurus	111-115
16304766-4	2005	In cells with BSCA1 and BRCA2 genes mutations the chromosome loci transference could not be induced by the X-radiation, but it could be induced by the RNA-polymerize II repression by alpha-amanitin.	Alpha-Amanitin	183-197	BRCA2 DNA repair associated	Homo sapiens	24-29
12799190-6	2003	The spatial distribution of nuclear DGK-theta was dynamic in that it was affected by inhibition of mRNA transcription with alpha-amanitin.	Alpha-Amanitin	123-137	diacylglycerol kinase theta	Homo sapiens	36-45
14585813-8	2004	Moreover, immunolocalization of RNA Pol I, but not of UBF, and the mRNA expression of PAF53 and UBF were significantly reduced or absent after culture with alpha-amanitin, indicating that RNA Pol I, PAF53, and presumably, UBF are derived from de novo embryonic transcription.	Alpha-Amanitin	156-170	RNA polymerase I subunit E	Homo sapiens	86-91
14585813-8	2004	Moreover, immunolocalization of RNA Pol I, but not of UBF, and the mRNA expression of PAF53 and UBF were significantly reduced or absent after culture with alpha-amanitin, indicating that RNA Pol I, PAF53, and presumably, UBF are derived from de novo embryonic transcription.	Alpha-Amanitin	156-170	upstream binding transcription factor	Homo sapiens	96-99
14585813-8	2004	Moreover, immunolocalization of RNA Pol I, but not of UBF, and the mRNA expression of PAF53 and UBF were significantly reduced or absent after culture with alpha-amanitin, indicating that RNA Pol I, PAF53, and presumably, UBF are derived from de novo embryonic transcription.	Alpha-Amanitin	156-170	RNA polymerase I subunit E	Homo sapiens	199-204
14585813-8	2004	Moreover, immunolocalization of RNA Pol I, but not of UBF, and the mRNA expression of PAF53 and UBF were significantly reduced or absent after culture with alpha-amanitin, indicating that RNA Pol I, PAF53, and presumably, UBF are derived from de novo embryonic transcription.	Alpha-Amanitin	156-170	upstream binding transcription factor	Homo sapiens	96-99
14598021-0	2004	The hepatocellular bile acid transporter Ntcp facilitates uptake of the lethal mushroom toxin alpha-amanitin.	Alpha-Amanitin	94-108	solute carrier family 10 member 1	Homo sapiens	41-45
14598021-3	2004	Because older data suggested that a sodium-dependent bile acid transporter is responsible for alpha-amanitin uptake, we tested the hypothesis that Na(+)-taurocholate cotransporter polypeptide (Ntcp) facilitates hepatocellular alpha-amanitin uptake.	Alpha-Amanitin	94-108	solute carrier family 10 member 1	Homo sapiens	193-197
14598021-3	2004	Because older data suggested that a sodium-dependent bile acid transporter is responsible for alpha-amanitin uptake, we tested the hypothesis that Na(+)-taurocholate cotransporter polypeptide (Ntcp) facilitates hepatocellular alpha-amanitin uptake.	Alpha-Amanitin	226-240	solute carrier family 10 member 1	Homo sapiens	147-191
14598021-3	2004	Because older data suggested that a sodium-dependent bile acid transporter is responsible for alpha-amanitin uptake, we tested the hypothesis that Na(+)-taurocholate cotransporter polypeptide (Ntcp) facilitates hepatocellular alpha-amanitin uptake.	Alpha-Amanitin	226-240	solute carrier family 10 member 1	Homo sapiens	193-197
14598021-6	2004	A toxicologically relevant functional assay for alpha-amanitin uptake was developed by measuring its ability to block cytokine-induced synthesis of interleukin-1 receptor antagonist (IL-1Ra) mRNA.	Alpha-Amanitin	48-62	interleukin 1 receptor antagonist	Homo sapiens	148-181
14598021-6	2004	A toxicologically relevant functional assay for alpha-amanitin uptake was developed by measuring its ability to block cytokine-induced synthesis of interleukin-1 receptor antagonist (IL-1Ra) mRNA.	Alpha-Amanitin	48-62	interleukin 1 receptor antagonist	Homo sapiens	183-189
14598021-8	2004	Pretreatment of transfected cells with 1 micro M alpha-amanitin for 6-10 h almost completely blocked induction of IL-1Ra mRNA (1.9-fold induction) whereas pretreatment of non-transfected cells did not block induction of IL-1Ra mRNA (21.6-fold induction, P<0.02 compared with stimulated transfected cells without alpha-amanitin).	Alpha-Amanitin	49-63	interleukin 1 receptor antagonist	Homo sapiens	114-120
14598021-9	2004	These findings demonstrate that Ntcp may be an important mediator of alpha-amanitin uptake by the liver.	Alpha-Amanitin	69-83	solute carrier family 10 member 1	Homo sapiens	32-36
15122760-3	2004	Because transcription inhibitors (actinomycin D, galactosamine, alpha-amanitin) sensitize primary hepatocytes to the cytotoxic action of tumor necrosis factor (TNF), we reasoned whether topoisomerase inhibitors would act similarly.	Alpha-Amanitin	64-78	tumor necrosis factor	Mus musculus	137-158
12774192-7	2003	We also evaluated the effects of alpha-amanitin, the main amatoxin, on in vitro insulin release.	Alpha-Amanitin	33-47	insulin	Homo sapiens	80-87
12774192-12	2003	Islets preincubated with 5 mg/l alpha-amanitin showed a pattern of glucose-stimulated insulin release similar to controls, whereas islets preincubated with 50 mg/l alpha-amanitin showed an increased basal release with a reduced response to glucose stimulation.	Alpha-Amanitin	32-46	insulin	Homo sapiens	86-93
12774192-14	2003	We demonstrate, for the first time, that alpha-amanitin induces insulin release and may exert a cytotoxic effect on beta cells.	Alpha-Amanitin	41-55	insulin	Homo sapiens	64-71
12578909-6	2003	The levels of SART3/p110 and LSm proteins in CBs were reduced upon treatment with the transcription inhibitor alpha-amanitin, suggesting that CB localization reflects active processes dependent on transcription/splicing.	Alpha-Amanitin	110-124	spliceosome associated factor 3, U4/U6 recycling protein	Homo sapiens	14-19
12770726-2	2003	In the rat ovary, the preovulatory surge of LH induces NGFI-B expression in granulosa cells of preovulatory follicles, reaching a peak within 1 h and declining to control levels at 6 h. The LH-stimulated NGFI-B expression is abolished by alpha-amanitin, but superinduced by cycloheximide.	Alpha-Amanitin	238-252	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	55-61
12770726-2	2003	In the rat ovary, the preovulatory surge of LH induces NGFI-B expression in granulosa cells of preovulatory follicles, reaching a peak within 1 h and declining to control levels at 6 h. The LH-stimulated NGFI-B expression is abolished by alpha-amanitin, but superinduced by cycloheximide.	Alpha-Amanitin	238-252	nuclear receptor subfamily 4 group A member 1	Homo sapiens	204-210
12686606-5	2003	Treatment of cells with actinomycin D, DRB, or alpha-amanitin, specific inhibitors of Pol II, disperses ELL and EAF1 from CBs, indicating that localization of ELL and EAF1 in CBs is dependent on active transcription by Pol II.	Alpha-Amanitin	47-61	elongation factor for RNA polymerase II	Homo sapiens	104-107
12686606-5	2003	Treatment of cells with actinomycin D, DRB, or alpha-amanitin, specific inhibitors of Pol II, disperses ELL and EAF1 from CBs, indicating that localization of ELL and EAF1 in CBs is dependent on active transcription by Pol II.	Alpha-Amanitin	47-61	ELL associated factor 1	Homo sapiens	112-116
12686606-5	2003	Treatment of cells with actinomycin D, DRB, or alpha-amanitin, specific inhibitors of Pol II, disperses ELL and EAF1 from CBs, indicating that localization of ELL and EAF1 in CBs is dependent on active transcription by Pol II.	Alpha-Amanitin	47-61	elongation factor for RNA polymerase II	Homo sapiens	159-162
12686606-5	2003	Treatment of cells with actinomycin D, DRB, or alpha-amanitin, specific inhibitors of Pol II, disperses ELL and EAF1 from CBs, indicating that localization of ELL and EAF1 in CBs is dependent on active transcription by Pol II.	Alpha-Amanitin	47-61	ELL associated factor 1	Homo sapiens	167-171
12578909-6	2003	The levels of SART3/p110 and LSm proteins in CBs were reduced upon treatment with the transcription inhibitor alpha-amanitin, suggesting that CB localization reflects active processes dependent on transcription/splicing.	Alpha-Amanitin	110-124	spliceosome associated factor 3, U4/U6 recycling protein	Homo sapiens	20-24
12533431-3	2003	MuERV-L expression was completely repressed when transcription from the zygotic genome was inhibited by alpha-amanitin.	Alpha-Amanitin	104-118	endogenous retroviral sequence 4 (with leucine tRNA primer)	Mus musculus	0-7
11932950-5	2002	Similar inhibition of ALP development was also observed in alpha-amanitin-injected embryos.	Alpha-Amanitin	59-73	alkaline phosphatase, placental	Homo sapiens	22-25
12405536-6	2002	Measurement of the selenoprotein W mRNA half-life in myoblasts treated with the transcription inhibitor, alpha-amanitin, showed that selenoprotein W mRNA levels decreased over time with an estimated half-life of 57 h for cells grown in low selenium medium.	Alpha-Amanitin	105-119	selenoprotein W	Rattus norvegicus	19-34
12405536-6	2002	Measurement of the selenoprotein W mRNA half-life in myoblasts treated with the transcription inhibitor, alpha-amanitin, showed that selenoprotein W mRNA levels decreased over time with an estimated half-life of 57 h for cells grown in low selenium medium.	Alpha-Amanitin	105-119	selenoprotein W	Rattus norvegicus	133-148
12724855-4	2003	Previously, we have used transcriptional inhibitors alpha-amanitin and actinomycin D to measure P-gp mRNA half-life in normal liver and in liver tumors.	Alpha-Amanitin	52-66	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
12473687-3	2002	Treatment of HeLa cells with alpha-amanitin or 5,6-dichlorobenzimidazole riboside (DRB) inhibited RNA polymerase II (pol II) transcription and led to the enlargement of lamin speckles as well as SFCs.	Alpha-Amanitin	29-43	lamin A/C	Homo sapiens	169-174
11932950-6	2002	While injection of alpha-amanitin at 24 hr prior to the emergence of ALP activity exerted inhibitory effects on ALP development, injection at 14 hr was no longer effective.	Alpha-Amanitin	19-33	alkaline phosphatase, placental	Homo sapiens	69-72
11932950-6	2002	While injection of alpha-amanitin at 24 hr prior to the emergence of ALP activity exerted inhibitory effects on ALP development, injection at 14 hr was no longer effective.	Alpha-Amanitin	19-33	alkaline phosphatase, placental	Homo sapiens	112-115
11955611-9	2002	TGFbeta was found to induce marked elongation of TSP-1 mRNA longevity in osteosarcoma cells when mRNA degradation was assayed in the presence of alpha-amanitin.	Alpha-Amanitin	145-159	transforming growth factor beta 1	Homo sapiens	0-7
11955611-9	2002	TGFbeta was found to induce marked elongation of TSP-1 mRNA longevity in osteosarcoma cells when mRNA degradation was assayed in the presence of alpha-amanitin.	Alpha-Amanitin	145-159	thrombospondin 1	Homo sapiens	49-54
11858729-8	2002	alpha-Amanitin inhibition studies and CAT assays demonstrated that CYP1B1 mRNA induction is associated with a transcriptional activation of its expression.	Alpha-Amanitin	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73
11964095-4	2002	Cyclin B1 protein was not detectable in embryos cultured in medium without alpha-amanitin for 5, 10, 18 or 25 h P4CC followed by culture in medium with alpha-amanitin to 33 P4CC.	Alpha-Amanitin	152-166	cyclin B1	Sus scrofa	0-9
11416027-8	2001	LH-stimulated NGFI-B expression in preovulatory follicles was abolished by alpha-amanitin, but was superinduced by cycloheximide.	Alpha-Amanitin	75-89	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	14-20
11553916-6	2001	However, if embryos were first exposed to alpha-amanitin after 18-hr P4CC with this treatment continuing to 33 hr, the levels of cdc25c transcript were reduced (P < 0.04) when compared to those embryos that were first exposed to the inhibitor at either 5- or 10-hr P4CC.	Alpha-Amanitin	42-56	cell division cycle 25C	Homo sapiens	129-135
10569990-6	1999	Treatment with alpha-amanitin from 5, 10, 18, or 25 h P4CC to 33 h P4CC resulted in cyclin B1 quantities that did not differ from those in the 33-h control embryos, irrespective of time spent in the inhibitor.	Alpha-Amanitin	15-29	cyclin B1	Homo sapiens	84-93
11152674-9	2001	The degradation of p57(Kip2) evoked by TGF-beta1 was blocked by forced expression of an inhibitory Smad called Smad7 or by the addition of actinomycin D or alpha-amanitin.	Alpha-Amanitin	156-170	cyclin dependent kinase inhibitor 1C	Homo sapiens	19-22
11152674-9	2001	The degradation of p57(Kip2) evoked by TGF-beta1 was blocked by forced expression of an inhibitory Smad called Smad7 or by the addition of actinomycin D or alpha-amanitin.	Alpha-Amanitin	156-170	cyclin dependent kinase inhibitor 1C	Homo sapiens	23-27
11152674-9	2001	The degradation of p57(Kip2) evoked by TGF-beta1 was blocked by forced expression of an inhibitory Smad called Smad7 or by the addition of actinomycin D or alpha-amanitin.	Alpha-Amanitin	156-170	transforming growth factor beta 1	Homo sapiens	39-48
10940310-7	2000	This protein-DNA complex could be labeled by incorporation of radioactive ribonucleotides into RNA in the presence of alpha-amanitin, suggesting that the polymerase I enzyme is part of the complex.	Alpha-Amanitin	118-132	DNA polymerase iota	Homo sapiens	154-166
11012721-4	2000	Data from mapping crosses of chromosome III support a role for a naturally occurring polymorphism in a multidrug resistance gene (Mdr65A) in alpha-amanitin resistance.	Alpha-Amanitin	141-155	Multi drug resistance 65	Drosophila melanogaster	130-136
11012721-6	2000	Therefore, if Mdr65A mutants contribute to the difference between alpha-amanitin-resistant and alpha-amanitin-sensitive third chromosome lines, the underlying cause is a gene regulatory mutation.	Alpha-Amanitin	66-80	Multi drug resistance 65	Drosophila melanogaster	14-20
10854226-4	2000	Under GSH depletion, also caspase-independent, TNF-R1-mediated injury (high-dose actinomycin D or alpha-amanitin), as well as necrotic hepatotoxicity (high-dose lipopolysaccharide) were entirely blocked.	Alpha-Amanitin	98-112	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	47-53
10386968-8	1999	TH protein level also failed to decline when cells were incubated for 3 days with a concentration of the transcription inhibitor alpha-amanitin that caused a >90% loss of TH mRNA.	Alpha-Amanitin	129-143	tyrosine hydroxylase	Bos taurus	0-2
10438658-0	1999	Influence of tumor necrosis factor-alpha and silibin on the cytotoxic action of alpha-amanitin in rat hepatocyte culture.	Alpha-Amanitin	80-94	tumor necrosis factor	Rattus norvegicus	13-40
10438658-2	1999	We examined whether exogenous tumor necrosis factor-alpha must be present for alpha-amanitin cytotoxicity in rat hepatocyte culture.	Alpha-Amanitin	78-92	tumor necrosis factor	Rattus norvegicus	30-57
10438658-7	1999	alpha-Amanitin alone does not increase but dose-dependently inhibits the expression of the antioxidant enzyme manganous superoxide dismutase and decreases the inducing effect of TNF-alpha on the expression of this enzyme.	Alpha-Amanitin	0-14	tumor necrosis factor	Rattus norvegicus	178-187
10438658-8	1999	The gene expression of endogenous tumor necrosis factor-alpha in the hepatocytes is not increased but rather inhibited by alpha-amanitin treatment.	Alpha-Amanitin	122-136	tumor necrosis factor	Rattus norvegicus	34-61
10386968-8	1999	TH protein level also failed to decline when cells were incubated for 3 days with a concentration of the transcription inhibitor alpha-amanitin that caused a >90% loss of TH mRNA.	Alpha-Amanitin	129-143	tyrosine hydroxylase	Bos taurus	174-176
10342860-9	1999	By comparison, the antiapoptotic effects of insulin-like growth factor I on germ cells in cultured fetal ovaries were significantly attenuated by cotreating ovaries with LY294002 (P < 0.05) but not with alpha-amanitin or cycloheximide (P > 0.05).	Alpha-Amanitin	206-220	insulin-like growth factor 1	Mus musculus	44-72
9195908-7	1997	Using in vitro nuclear run-on transcription assay and Northern blot analysis of alpha-amanitin-treated cells, IL-1-mediated rGSTM1 mRNA decrease was found to result from mRNA destabilization.	Alpha-Amanitin	80-94	glutathione S-transferase mu 1	Rattus norvegicus	124-130
9927311-6	1999	Treatment with cycloheximide or alpha-amanitin abolished LH-induced PACAP transcripts, indicating that new protein synthesis and transcription are necessary.	Alpha-Amanitin	32-46	adenylate cyclase activating polypeptide 1	Rattus norvegicus	68-73
9389644-4	1997	In vivo, disruption of chromatin in the first 400 bp of the transcribed region of hsp70 following heat shock is resistant to the transcriptional inhibitor alpha-amanitin.	Alpha-Amanitin	155-169	heat shock protein family A (Hsp70) member 4	Homo sapiens	82-87
9389644-5	1997	Disruption of chromatin farther downstream also occurs following activation but is sensitive to alpha-amanitin, suggesting that polymerase movement is needed to disrupt distal portions of the hsp70 gene.	Alpha-Amanitin	96-110	heat shock protein family A (Hsp70) member 4	Homo sapiens	192-197
9843505-7	1998	Upon transcriptional inhibition by alpha-amanitin or actinomycin D, the protein gradually redistributes until it localizes fully to interchromatin granule clusters, together with the splicing factor SC35.	Alpha-Amanitin	35-49	serine and arginine rich splicing factor 2	Homo sapiens	199-203
9828212-6	1998	An equally rapid loss of PC-1 protein and mRNA could also be provoked in normal livers by the administration of the translational inhibitor, cycloheximide, but the transcriptional inhibitors, actinomycin D and alpha-amanitin, did not show these effects.	Alpha-Amanitin	210-224	ectonucleotide pyrophosphatase/phosphodiesterase 1	Rattus norvegicus	25-29
9770348-11	1998	An inhibitor of transcription, alpha-amanitin, dramatically induced wt p53 protein, whereas Mdm-2 protein was downregulated.	Alpha-Amanitin	31-45	tumor protein p53	Homo sapiens	71-74
9738911-11	1998	Northern blots of alpha-amanitin-treated polyps demonstrated that the half-life of hsp70 mRNA in heat-shocked H. oligactis is drastically shorter than in H. magnipapillata.	Alpha-Amanitin	18-32	heat shock 70 kDa protein	Hydra vulgaris	83-88
9299125-8	1997	Apoptosis induced by cycloheximide or alpha-amanitin was blocked by injection of RNA encoding Xenopus Bcl-2, suggesting that this maternal program is normally blocked by expression of an apoptotic inhibitor.	Alpha-Amanitin	38-52	B-cell CLL/lymphoma 2 S homeolog	Xenopus laevis	102-107
8760875-3	1996	We have found that in murine fibroblasts exposure to alpha-amanitin triggered degradation of the RPB1 subunit, while other RNAPII subunits, RPB5 and RPB8, remained almost unaffected.	Alpha-Amanitin	53-67	polymerase (RNA) II (DNA directed) polypeptide A	Mus musculus	97-101
9029737-6	1997	The down-regulation of aromatase, SF-1, and RII beta by each kinase activator and alpha-amanitin was prevented by cycloheximide when the drug was added in combination with the activator.	Alpha-Amanitin	82-96	splicing factor 1	Rattus norvegicus	34-38
8859220-11	1996	In addition, an inhibitor of RNA polymerase, alpha-amanitin, dose-dependently decreased this histamine-induced augmentation of VCAM-1 expression.	Alpha-Amanitin	45-59	vascular cell adhesion molecule 1	Homo sapiens	127-133
8814143-10	1996	Additionally, both actinomycin D and alpha-amanitin inhibited the increase in uPA mRNA by PAF.	Alpha-Amanitin	37-51	urokinase-type plasminogen activator	Oryctolagus cuniculus	78-81
8703990-12	1996	FACS analysis of taxol -treated and alpha-amanitin-treated cells corroborated these data.	Alpha-Amanitin	36-50	acyl-CoA synthetase long-chain family member 1	Mus musculus	0-4
9202172-5	1997	The increase in the level of Grp75 was completely blocked by cycloheximide, but only partially blocked by the inhibitors of mRNA synthesis actinomycin D and alpha-amanitin.	Alpha-Amanitin	157-171	stress-70 protein, mitochondrial	Cricetulus griseus	29-34
9041255-4	1997	RESULTS: TNF induced apoptosis of murine hepatocytes or human hepatoma cells in the presence of alpha-amanitin or ActD.	Alpha-Amanitin	96-110	tumor necrosis factor	Mus musculus	9-12
9041255-6	1997	After in vivo administration of high doses of ActD or alpha-amanitin alone, hepatic TNF-messenger RNA was increased and hepatocytes underwent apoptosis.	Alpha-Amanitin	54-68	tumor necrosis factor	Mus musculus	84-87
9041255-9	1997	Mice deficient for the 55-kilodalton TNF receptor were protected from ActD- or alpha-amanitin-induced toxicity.	Alpha-Amanitin	79-93	tumor necrosis factor	Mus musculus	37-40
9041255-11	1997	CONCLUSIONS: Hepatotoxins such as alpha-amanitin may induce liver failure by an indirect mechanism involving sensitization of parenchymal cells toward endogenously produced TNF.	Alpha-Amanitin	34-48	tumor necrosis factor	Mus musculus	173-176
8760875-4	1996	Transcriptional inhibition in alpha-amanitin-treated cells was slow and closely followed the disappearance of RPB1.	Alpha-Amanitin	30-44	polymerase (RNA) II (DNA directed) polypeptide A	Mus musculus	110-114
8760875-5	1996	The degradation rate of RPB1 was alpha-amanitin dose dependent and was not a consequence of transcriptional arrest.	Alpha-Amanitin	33-47	polymerase (RNA) II (DNA directed) polypeptide A	Mus musculus	24-28
8760875-6	1996	Alpha-Amanitin-promoted degradation of RPB1 was prevented in cells exposed to actinomycin D, another transcriptional inhibitor.	Alpha-Amanitin	0-14	polymerase (RNA) II (DNA directed) polypeptide A	Mus musculus	39-43
8760875-9	1996	Hence, alpha-amanitin did not activate a proteolytic system, but instead its binding to mRPB1 likely represented a signal for degradation.	Alpha-Amanitin	7-21	polymerase (RNA) II (DNA directed) polypeptide A	Mus musculus	88-93
8935992-4	1996	We utilized the resistance to the transcriptional inhibitor alpha-amanitin conferred by RpII215(4) to show that RpII215(4)/+ flies raised on alpha-amanitin-containing food still show the Ubx effect and are indistinguishable from flies raised on normal food.	Alpha-Amanitin	60-74	RNA polymerase II 215kD subunit	Drosophila melanogaster	88-95
8612682-7	1996	Interestingly, both alpha-amanitin and AMD cause coilin to associate with the nucleolar domain.	Alpha-Amanitin	20-34	coilin	Homo sapiens	49-55
8612682-9	1996	After alpha-amanitin treatment, coilin is concentrated in numerous beads closely associated with individual rDNA transcription units within nucleolar necklaces.	Alpha-Amanitin	6-20	coilin	Homo sapiens	32-38
8631492-4	1996	Using this approach we find a transient increase in the mRNA abundance of the translation initiation factor eIF-4C that is inhibited by alpha-amanitin and correlated with a transient increase in the relative rate of protein synthesis for eIF-4C.	Alpha-Amanitin	136-150	eukaryotic translation initiation factor 1A, X-linked	Mus musculus	108-114
8631492-4	1996	Using this approach we find a transient increase in the mRNA abundance of the translation initiation factor eIF-4C that is inhibited by alpha-amanitin and correlated with a transient increase in the relative rate of protein synthesis for eIF-4C.	Alpha-Amanitin	136-150	eukaryotic translation initiation factor 1A, X-linked	Mus musculus	238-244
8935992-4	1996	We utilized the resistance to the transcriptional inhibitor alpha-amanitin conferred by RpII215(4) to show that RpII215(4)/+ flies raised on alpha-amanitin-containing food still show the Ubx effect and are indistinguishable from flies raised on normal food.	Alpha-Amanitin	141-155	Ultrabithorax	Drosophila melanogaster	187-190
8935992-4	1996	We utilized the resistance to the transcriptional inhibitor alpha-amanitin conferred by RpII215(4) to show that RpII215(4)/+ flies raised on alpha-amanitin-containing food still show the Ubx effect and are indistinguishable from flies raised on normal food.	Alpha-Amanitin	60-74	RNA polymerase II 215kD subunit	Drosophila melanogaster	112-119
8935992-4	1996	We utilized the resistance to the transcriptional inhibitor alpha-amanitin conferred by RpII215(4) to show that RpII215(4)/+ flies raised on alpha-amanitin-containing food still show the Ubx effect and are indistinguishable from flies raised on normal food.	Alpha-Amanitin	60-74	Ultrabithorax	Drosophila melanogaster	187-190
8935992-4	1996	We utilized the resistance to the transcriptional inhibitor alpha-amanitin conferred by RpII215(4) to show that RpII215(4)/+ flies raised on alpha-amanitin-containing food still show the Ubx effect and are indistinguishable from flies raised on normal food.	Alpha-Amanitin	141-155	RNA polymerase II 215kD subunit	Drosophila melanogaster	112-119
8653400-4	1995	Further, Northern analysis of RNA from neurons maintained in the presence of the transcription inhibitor, alpha-amanitin, showed that glutamate shortened the half life of the ligatin message from 10 h to 58 min.	Alpha-Amanitin	106-120	ligatin	Homo sapiens	175-182
7488195-6	1995	This increase was blocked by alpha-amanitin, suggesting that active transcription is necessary and was associated with increased AP1 binding activities.	Alpha-Amanitin	29-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-132
7479000-3	1995	And the L1 internal promoter, unlike other internal promoters, is thought to be RNA polymerase II (pol II) dependent, because the L1 transcript has a large size (approximately 6 kb), protein coding capacity and a 3" terminal polyadenylation signal followed by a poly(A) tail, and also because transcription from the promoter of Drosophila L1-like element jockey was highly sensitive to alpha-amanitin.	Alpha-Amanitin	386-400	l(1)L1	Drosophila melanogaster	8-10
7479000-3	1995	And the L1 internal promoter, unlike other internal promoters, is thought to be RNA polymerase II (pol II) dependent, because the L1 transcript has a large size (approximately 6 kb), protein coding capacity and a 3" terminal polyadenylation signal followed by a poly(A) tail, and also because transcription from the promoter of Drosophila L1-like element jockey was highly sensitive to alpha-amanitin.	Alpha-Amanitin	386-400	RNA polymerase II 215kD subunit	Drosophila melanogaster	99-105
7479000-3	1995	And the L1 internal promoter, unlike other internal promoters, is thought to be RNA polymerase II (pol II) dependent, because the L1 transcript has a large size (approximately 6 kb), protein coding capacity and a 3" terminal polyadenylation signal followed by a poly(A) tail, and also because transcription from the promoter of Drosophila L1-like element jockey was highly sensitive to alpha-amanitin.	Alpha-Amanitin	386-400	l(1)L1	Drosophila melanogaster	130-132
7493649-4	1995	Both cycloheximide and alpha-amanitin inhibited the increase in uPAR mRNA levels, demonstrating the requirement for the de novo synthesis of a short-lived protein for transcriptional activation.	Alpha-Amanitin	23-37	plasminogen activator, urokinase receptor	Homo sapiens	64-68
7488101-5	1995	We report that TRiC-P5 is synthesized at the 2-cell stage in an alpha-amanitin sensitive manner.	Alpha-Amanitin	64-78	chaperonin containing Tcp1, subunit 3 (gamma)	Mus musculus	15-22
7750638-3	1995	Experiments with the protein synthesis inhibitors, cycloheximide and anisomycin, and the mRNA synthesis inhibitor, alpha-amanitin, showed that 20E induced a protein(s) which suppressed transcription of the DDC gene.	Alpha-Amanitin	115-129	Dopa decarboxylase	Drosophila melanogaster	206-209
7643127-4	1995	Using nuclear run-on assays and northern analyses of total RNA from alpha-amanitin-treated cells, we measured the effects of glutamate on the transcriptional activity and mRNA stability of the ligatin gene.	Alpha-Amanitin	68-82	ligatin	Homo sapiens	193-200
7609077-7	1995	Tax1 transactivation was inhibited by low concentrations of alpha-amanitin and was effectively neutralized by anti-Tax1 but not control sera.	Alpha-Amanitin	60-74	contactin 2	Homo sapiens	0-4
7642577-3	1995	10 microgram/ml alpha-amanitin completely inhibited DmS-II-mediated transcript cleavage but allowed extended pyrophosphorolysis and nucleotide addition to occur.	Alpha-Amanitin	16-30	RNA polymerase II elongation factor	Drosophila melanogaster	52-58
7790384-12	1995	The rate of mdr1b mRNA decay in primary d-15 UE cells was decreased by treatment with alpha-amanitin or cycloheximide, suggesting that the decay pathway requires both transcription and de novo protein synthesis.	Alpha-Amanitin	86-100	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	12-17
7545067-7	1995	Cyclohexamide eliminated nearly all and alpha-amanitin reduced by half the TH induction elicited by DA and BDNF; indicating that both de novo transcription and translation were required for increased expression.	Alpha-Amanitin	40-54	tyrosine hydroxylase	Homo sapiens	75-77
7545067-7	1995	Cyclohexamide eliminated nearly all and alpha-amanitin reduced by half the TH induction elicited by DA and BDNF; indicating that both de novo transcription and translation were required for increased expression.	Alpha-Amanitin	40-54	brain derived neurotrophic factor	Homo sapiens	107-111
7528686-2	1994	Upon removal of CSF-1 from bone marrow-derived macrophages (BMM), uPA mRNA decayed with a half-life of 2 h. If RNA synthesis inhibitors actinomycin D, 5,6-dichloro-1-beta-ribofuranosyl benzimidazole (DRB) or alpha-amanitin were added at the time as CSF-1 removal, the uPA message was stabilised.	Alpha-Amanitin	208-222	colony stimulating factor 1	Homo sapiens	16-21
7636805-3	1995	The increase in prostaglandin E2 accumulation induced by epidermal growth factor was inhibited by alpha-amanitin (2 micrograms ml-1), cycloheximide (0.5 micrograms ml-1) and dexamethasone (5 mumol l-1).	Alpha-Amanitin	98-112	epidermal growth factor like 1	Rattus norvegicus	57-80
7636805-4	1995	Epidermal growth factor increased cyclooxygenase activity in the stromal cells in a time-dependent fashion and this increase in activity was also inhibited by alpha-amanitin, cycloheximide and dexamethasone.	Alpha-Amanitin	159-173	epidermal growth factor like 1	Rattus norvegicus	0-23
7867493-1	1995	Activation of the mouse embryonic genome at the 2-cell stage is characterized by the synthesis of several alpha-amanitin-sensitive polypeptides, some of which belong to the multigenic hsp 70 family.	Alpha-Amanitin	106-120	heat shock protein 1B	Mus musculus	184-190
7619501-1	1995	Mouse embryos produced by the fertilization of eggs from (B6D2)F1 and CF-1 mice differ in their ability to complete the second cell cycle in the presence of alpha-amanitin.	Alpha-Amanitin	157-171	forkhead box G1	Mus musculus	58-65
7528686-2	1994	Upon removal of CSF-1 from bone marrow-derived macrophages (BMM), uPA mRNA decayed with a half-life of 2 h. If RNA synthesis inhibitors actinomycin D, 5,6-dichloro-1-beta-ribofuranosyl benzimidazole (DRB) or alpha-amanitin were added at the time as CSF-1 removal, the uPA message was stabilised.	Alpha-Amanitin	208-222	plasminogen activator, urokinase	Homo sapiens	66-69
7996055-3	1994	Both an RNA polymerase II antagonist, alpha-amanitin, and a specific GC antagonist, RU38486, inhibited the enhancement of SAA3 mRNA expression by DEX.	Alpha-Amanitin	38-52	serum amyloid A3, pseudogene	Homo sapiens	122-126
8084582-9	1994	Inhibition of transcription with alpha-amanitin evokes nuclear accumulation of p53 both in normal cells and in XP cells.	Alpha-Amanitin	33-47	tumor protein p53	Homo sapiens	79-82
7964719-9	1994	Studies using alpha-amanitin, an inhibitor of RNA polymerase II, showed that NH4Cl decreased the stability of GFAP mRNA by approximately 50%.	Alpha-Amanitin	14-28	glial fibrillary acidic protein	Homo sapiens	110-114
8154183-5	1993	Transcription in all of the extracts was sensitive to inhibition by alpha-amanitin, indicating that it was catalysed by RNA polymerase II, and was dramatically stimulated by the chimeric activator GAL4/VP16.	Alpha-Amanitin	68-82	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	197-201
8046244-2	1994	However, TNF-alpha induced a concentration-dependent cell death in hepatocytes that had been pretreated with the transcriptional inhibitors actinomycin D (ActD), D-galactosamine, or alpha-amanitin.	Alpha-Amanitin	182-196	tumor necrosis factor	Mus musculus	9-18
8061605-0	1994	A beta-turn in alpha-amanitin is the most important structural feature for binding to RNA polymerase II and three monoclonal antibodies.	Alpha-Amanitin	15-29	amyloid beta precursor protein	Homo sapiens	0-6
8167153-3	1994	Inhibition of the response to IL-6 by cycloheximide and alpha-amanitin indicates that increases in PAI-1 are dependent on both protein and RNA synthesis.	Alpha-Amanitin	56-70	interleukin 6	Homo sapiens	30-34
8167153-3	1994	Inhibition of the response to IL-6 by cycloheximide and alpha-amanitin indicates that increases in PAI-1 are dependent on both protein and RNA synthesis.	Alpha-Amanitin	56-70	serpin family E member 1	Homo sapiens	99-104
1324671-4	1992	ET-1 also induced an increase in u-PAR mRNA level, which was completely blocked by alpha-amanitin (5 micrograms/ml).	Alpha-Amanitin	83-97	endothelin 1	Homo sapiens	0-4
8344262-5	1993	The disruption of nuc-1 from DNA is independent of DNA replication since it is completed in 20 min and independent of transcription as it is alpha-amanitin insensitive.	Alpha-Amanitin	141-155	peroxisome proliferator activated receptor delta	Homo sapiens	18-23
8471070-13	1993	Since this increase in 2E1 synthesis stems, at least in part, from the acetone-mediated enhancement of hepatocyte 2E1 mRNA content and is inhibitable by alpha-amanitin, transcriptional activation of the rabbit CYP2E1 gene is apparently involved in the induction of 2E1 protein by acetone.	Alpha-Amanitin	153-167	cytochrome P450 2E1	Oryctolagus cuniculus	210-216
1324671-4	1992	ET-1 also induced an increase in u-PAR mRNA level, which was completely blocked by alpha-amanitin (5 micrograms/ml).	Alpha-Amanitin	83-97	plasminogen activator, urokinase receptor	Homo sapiens	33-38
7685022-8	1993	The catalytic activity of RdRP is resistant to alpha-amanitin and actinomycin D.	Alpha-Amanitin	47-61	RNA-directed RNA polymerase	Solanum lycopersicum	26-30
1335698-2	1992	The increase in ACE activity was preceded by an increase in ACE mRNA, which could be detected after treatment of cells with dexamethasone for 4 h. When the increase in ACE mRNA produced by dexamethasone at 4 h was blocked by alpha-amanitin, an RNA polymerase II inhibitor, the increase in ACE activity detected at 48 h was inhibited.	Alpha-Amanitin	225-239	angiotensin I converting enzyme	Bos taurus	16-19
1335698-2	1992	The increase in ACE activity was preceded by an increase in ACE mRNA, which could be detected after treatment of cells with dexamethasone for 4 h. When the increase in ACE mRNA produced by dexamethasone at 4 h was blocked by alpha-amanitin, an RNA polymerase II inhibitor, the increase in ACE activity detected at 48 h was inhibited.	Alpha-Amanitin	225-239	angiotensin I converting enzyme	Bos taurus	60-63
1335698-2	1992	The increase in ACE activity was preceded by an increase in ACE mRNA, which could be detected after treatment of cells with dexamethasone for 4 h. When the increase in ACE mRNA produced by dexamethasone at 4 h was blocked by alpha-amanitin, an RNA polymerase II inhibitor, the increase in ACE activity detected at 48 h was inhibited.	Alpha-Amanitin	225-239	angiotensin I converting enzyme	Bos taurus	60-63
1335698-2	1992	The increase in ACE activity was preceded by an increase in ACE mRNA, which could be detected after treatment of cells with dexamethasone for 4 h. When the increase in ACE mRNA produced by dexamethasone at 4 h was blocked by alpha-amanitin, an RNA polymerase II inhibitor, the increase in ACE activity detected at 48 h was inhibited.	Alpha-Amanitin	225-239	angiotensin I converting enzyme	Bos taurus	60-63
1446624-6	1992	While pulse-chase studies demonstrated that total (medium plus cell-associated) collagen levels were stable throughout the 48-h period, TGF beta 1 increased the fraction of cell-associated collagen between 24-48 h, and this was partially blocked by alpha-amanitin, but not by antibody to fibronectin or beta 1-integrin subunit.	Alpha-Amanitin	249-263	transforming growth factor, beta 1	Rattus norvegicus	136-146
1446624-6	1992	While pulse-chase studies demonstrated that total (medium plus cell-associated) collagen levels were stable throughout the 48-h period, TGF beta 1 increased the fraction of cell-associated collagen between 24-48 h, and this was partially blocked by alpha-amanitin, but not by antibody to fibronectin or beta 1-integrin subunit.	Alpha-Amanitin	249-263	fibronectin 1	Rattus norvegicus	288-299
1497870-5	1992	In eggs collected at the pronuclear stage and cultured to the late two-cell stage in the presence of alpha-amanitin, the matrix morphology was altered for Pl1 and Pl2.	Alpha-Amanitin	101-115	lethal, Chr 9, Russell 1	Mus musculus	155-158
1497870-5	1992	In eggs collected at the pronuclear stage and cultured to the late two-cell stage in the presence of alpha-amanitin, the matrix morphology was altered for Pl1 and Pl2.	Alpha-Amanitin	101-115	lethal, Chr 9, Russell 2	Mus musculus	163-166
1995295-4	1991	This effect, which is time- and dose-dependent (0.05-5 ng/ml), is restricted to PDGF-AA, one of the three PDGF isoforms; IL-1 beta effect on PDGF is inhibited by actinomycin D and alpha-amanitin, suggesting a transcriptional regulation of PDGF-A chain.	Alpha-Amanitin	180-194	interleukin-1 beta	Oryctolagus cuniculus	121-130
1934297-5	1991	However, if cells were treated with either actinomycin D, alpha-amanitin or cordycepin, which are inhibitors of RNA synthesis, after exposure to cycloheximide, prominent induction of AHH activity was observed, the levels being almost equal to those for hepatocytes treated with benz[a]anthracene, a potent AHH inducer.	Alpha-Amanitin	58-72	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	183-186
1934297-5	1991	However, if cells were treated with either actinomycin D, alpha-amanitin or cordycepin, which are inhibitors of RNA synthesis, after exposure to cycloheximide, prominent induction of AHH activity was observed, the levels being almost equal to those for hepatocytes treated with benz[a]anthracene, a potent AHH inducer.	Alpha-Amanitin	58-72	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	306-309
1930253-4	1991	The observed inhibition (40-70%) of RNA polymerase II-directed RNA synthesis (based on alpha-amanitin sensitivity) in isolated nuclei of heat-treated cells was also significantly reversed by the simultaneous addition of IFN.	Alpha-Amanitin	87-101	interferon alpha 1	Homo sapiens	220-223
33803263-0	2021	Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro.	Alpha-Amanitin	64-78	MARVEL domain containing 2	Homo sapiens	30-34
1905567-6	1991	In the presence of aphidicolin, alpha-amanitin, and actinomycin D, positive cells for N-myc gene product decreased markedly.	Alpha-Amanitin	32-46	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	86-91
1905567-8	1991	But northern blot analysis demonstrated that the expression level of N-myc gene was only repressed by the transcriptional inhibitors alpha-amanitin and actinomycin D.	Alpha-Amanitin	133-147	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
2325130-5	1990	We compared the effects of alpha-amanitin and actinomycin D on the transcription of c-fos and c-myc with the effects of each inhibitor on the distribution of the corresponding oncogenic DNA sequences in the chromatographically separated nucleosome fractions.	Alpha-Amanitin	27-41	FBJ osteosarcoma oncogene	Mus musculus	84-89
2325130-6	1990	It was found that the inhibition of RNA polymerase II by alpha-amanitin (added at the peaks of c-fos or c-myc expression in serum-stimulated BALB/c 3T3 cells) resulted in a rapid loss of affinity of the oncogene-containing nucleosomes for the mercury column.	Alpha-Amanitin	57-71	FBJ osteosarcoma oncogene	Mus musculus	95-100
1829092-4	1991	By using alpha-amanitin, an inhibitor of DNA-dependent RNA polymerase, we were able to show that the first embryonic mRNA transcriptions of the beta-N-acetylhexosaminidase genes take place between 38 and 46 h post HCG (early 2-cell stage) and between 46 and 54 h post HCG (late 2-cell stage).	Alpha-Amanitin	9-23	O-GlcNAcase	Mus musculus	144-171
34639119-8	2021	Treatment with HLSC-EVs caused increased expression of miR29b, which was significantly inhibited in the presence of alpha-amanitin.	Alpha-Amanitin	116-130	microRNA 29b-1	Homo sapiens	55-61
34154403-7	2021	We discovered that albumin, similarly, can neutralize a variety of fungal (alpha-amanitin), bacterial (streptolysin O and staurosporin), and insect (melittin) hydrophobic toxins.	Alpha-Amanitin	75-89	albumin	Homo sapiens	19-26
35015118-5	2022	To address the role of RNA polymerase II-mediated transcription for CID loading in early Drosophila embryos, we have quantified the effects of alpha-amanitin and triptolide on centromeric CID-EGFP levels.	Alpha-Amanitin	143-157	centromere identifier	Drosophila melanogaster	188-191
2564622-7	1989	All transcripts were inhibited by the polymerase II inhibitor, alpha-amanitin.	Alpha-Amanitin	63-77	RNA polymerase II, I and III subunit F	Rattus norvegicus	38-51
2792759-3	1989	We confirmed this observation in microinjected oocytes and showed that the alpha-amanitin-resistant transcription of c-myc was competed by known polymerase III genes.	Alpha-Amanitin	75-89	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	117-122
2476654-6	1989	The approximately 2.7 kb arylsulfatase transcript is very susceptible to degradation, disappearing in less than an hour after sulfur starved cells are administered either sulfate or alpha-amanitin.	Alpha-Amanitin	182-196	uncharacterized protein	Chlamydomonas reinhardtii	25-38
2877996-4	1986	The induction of TH by PM was blocked by alpha-amanitin as observed in high density cultures.	Alpha-Amanitin	41-55	tyrosine hydroxylase	Bos taurus	17-19
3165095-9	1988	mRNA synthesis inhibition with alpha-amanitin blocked this TNF effect, as did cAMP but not cGMP analogues.	Alpha-Amanitin	31-45	tumor necrosis factor	Homo sapiens	59-62
2449340-8	1988	Results obtained with actinomycin-D and alpha-amanitin suggest that the above effects of bFGF can be correlated with increased RNA stability produced by bFGF.	Alpha-Amanitin	40-54	fibroblast growth factor 2	Rattus norvegicus	89-93
2449340-8	1988	Results obtained with actinomycin-D and alpha-amanitin suggest that the above effects of bFGF can be correlated with increased RNA stability produced by bFGF.	Alpha-Amanitin	40-54	fibroblast growth factor 2	Rattus norvegicus	153-157
3107751-3	1987	This specific increase of c-fos steady-state levels is dependent on the incubation time with a maximal level of induction (over 40-fold) after approximately 1 h. The accumulation of c-fos transcripts is suppressed by alpha-amanitin while cycloheximide intensifies induction only moderately.	Alpha-Amanitin	217-231	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31
3107751-3	1987	This specific increase of c-fos steady-state levels is dependent on the incubation time with a maximal level of induction (over 40-fold) after approximately 1 h. The accumulation of c-fos transcripts is suppressed by alpha-amanitin while cycloheximide intensifies induction only moderately.	Alpha-Amanitin	217-231	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
3031058-2	1987	The hormone-mediated increase in tyrosinase activity is dependent upon continued transcription since the enzyme induction is suppressed by either cordycepin (1 microgram/ml) or alpha-amanitin (10 micrograms/ml).	Alpha-Amanitin	177-191	tyrosinase	Mus musculus	33-43
3096698-4	1986	Up to 85% of the cells became immunofluorescently labeled in the presence of FSH, and its induced P-450scc synthesis was inhibited by cycloheximide and alpha-amanitin.	Alpha-Amanitin	152-166	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	98-106
3263853-5	1988	Measurement of RNA half life after addition of alpha-amanitin (an inhibitor of RNA polymerase II) indicate that IL-1 alpha mRNA is not as stable as IL-1 beta mRNA suggesting one mechanism for the different relative levels of RNA.	Alpha-Amanitin	47-61	interleukin 1 alpha	Homo sapiens	112-122
2842063-3	1988	alpha-amanitin experiments indicate that jockey is transcribed by RNA polymerase II.	Alpha-Amanitin	0-14	RNA polymerase II 215kD subunit	Drosophila melanogaster	66-83
2897311-11	1988	Since alpha-amanitin inhibited the increase in TH levels, we conclude that cell-cell contact regulates TH in PC12 cells at the transcriptional level.	Alpha-Amanitin	6-20	tyrosine hydroxylase	Rattus norvegicus	47-49
2897311-11	1988	Since alpha-amanitin inhibited the increase in TH levels, we conclude that cell-cell contact regulates TH in PC12 cells at the transcriptional level.	Alpha-Amanitin	6-20	tyrosine hydroxylase	Rattus norvegicus	103-105
2829145-4	1987	CRF and alpha-amanitin (inhibitor of RNA polymerase II activity) were also found to affect POMC mRNA levels in a concentration-dependent fashion.	Alpha-Amanitin	8-22	pro-opiomelanocortin-alpha	Mus musculus	91-95
2829145-6	1987	It was also found that alpha-amanitin negatively regulated basal and CRF-stimulated POMC mRNA levels at both the 2 hr and 24 hr time periods, supporting evidence for positive regulation of POMC by CRF at the transcriptional level.	Alpha-Amanitin	23-37	pro-opiomelanocortin-alpha	Mus musculus	84-88
2829145-6	1987	It was also found that alpha-amanitin negatively regulated basal and CRF-stimulated POMC mRNA levels at both the 2 hr and 24 hr time periods, supporting evidence for positive regulation of POMC by CRF at the transcriptional level.	Alpha-Amanitin	23-37	pro-opiomelanocortin-alpha	Mus musculus	189-193
3611064-8	1987	Actinomycin D and alpha-amanitin, which are inhibitors of transcription, also blocked the early dexamethasone effect on plasma fibronectin synthesis.	Alpha-Amanitin	18-32	fibronectin 1	Gallus gallus	127-138
3096577-3	1986	Injections of alpha-amanitin revealed that ftz RNA turns over extremely rapidly in the embryo, and we think that this may be essential to effect rapid changes in ftz RNA patterns.	Alpha-Amanitin	14-28	fushi tarazu	Drosophila melanogaster	43-46
3096577-3	1986	Injections of alpha-amanitin revealed that ftz RNA turns over extremely rapidly in the embryo, and we think that this may be essential to effect rapid changes in ftz RNA patterns.	Alpha-Amanitin	14-28	fushi tarazu	Drosophila melanogaster	162-165
4002211-1	1985	The administration of 0.2 micrograms/g/bw of alpha-amanitin to approximately 20 g rats provoked the following nuclear modifications in rat adrenal fasciculata cells at 60 min: chromatin condensation, nucleolar fragmentation, increase in the number of PCG and clumping of ICG in the center of the nucleus.	Alpha-Amanitin	45-59	psoriasis susceptibility 1 candidate 2	Rattus norvegicus	251-254
3776348-1	1986	Our previous studies employing alpha-amanitin-sensitive H-9 and resistant Ama 102 mutant host cells demonstrated that polymerase II (Pol II), or a drug-sensitive component of the enzyme, is required for replication of vaccinia virus.	Alpha-Amanitin	31-45	G protein-coupled receptor 50	Rattus norvegicus	56-59
3721058-7	1986	RCP induction was completely inhibited by both alpha-amanitin and cycloheximide for prolonged periods while E-stimulated RBP production was affected only partially by alpha-amanitin.	Alpha-Amanitin	47-61	CGRP receptor component	Homo sapiens	0-3
2870781-11	1986	Treatment with alpha-amanitin resulted in a complete suppression of the activity of ODC (a protein with a very short half life), in both the control and dexamethasone treated cultures.	Alpha-Amanitin	15-29	ornithine decarboxylase 1	Rattus norvegicus	84-87
6488182-14	1984	The induction of ALDH is blocked by actinomycin D, alpha-amanitin, and cycloheximide.	Alpha-Amanitin	51-65	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	17-21
6598004-4	1984	The inhibition of UMP incorporation by 2 micrograms/ml alpha-amanitin was much greater at 23 degrees C than at 37 degrees C. The molecular weight of the RNA synthesized in permeabilized cells is broadly distributed with about 83% larger than 18 S. In vitro transcription of the mouse beta-major globin gene was studied by hybridizing 32P-labeled nascent RNA to filter-bound DNA sequences representing this gene and its flanking regions.	Alpha-Amanitin	55-69	hemoglobin, beta adult major chain	Mus musculus	284-301
6145760-4	1984	We have compared NGF-mediated TH and AChE induction and have provided pharmacological evidence that TH induction involves a post-transcriptional, polyadenylation-dependent event (blockable by 9-beta-arabinofuranosyladenine but not by alpha-amanitin), whereas AChE induction requires transcription (blockable by alpha-amanitin).	Alpha-Amanitin	234-248	tyrosine hydroxylase	Bos taurus	100-102
6481855-6	1984	Low concentrations of alpha-amanitin (2 micrograms/ml) inhibited IAP RNA synthesis by greater than 90%, suggesting that RNA polymerase II is responsible for IAP transcription.	Alpha-Amanitin	22-36	intracisternal A particle, Eya1 linked	Mus musculus	65-68
6481855-6	1984	Low concentrations of alpha-amanitin (2 micrograms/ml) inhibited IAP RNA synthesis by greater than 90%, suggesting that RNA polymerase II is responsible for IAP transcription.	Alpha-Amanitin	22-36	intracisternal A particle, Eya1 linked	Mus musculus	157-160
6145760-4	1984	We have compared NGF-mediated TH and AChE induction and have provided pharmacological evidence that TH induction involves a post-transcriptional, polyadenylation-dependent event (blockable by 9-beta-arabinofuranosyladenine but not by alpha-amanitin), whereas AChE induction requires transcription (blockable by alpha-amanitin).	Alpha-Amanitin	311-325	tyrosine hydroxylase	Bos taurus	100-102
6410926-8	1983	Cordycepin (0.1 mg/ml) or alpha-amanitin (10 micrograms/ml) partially inhibited insulin effects on ribosomes and protein synthesis but not on lipoprotein lipase.	Alpha-Amanitin	26-40	insulin	Homo sapiens	80-87
6743315-3	1984	The in vitro results further demonstrate that both DNA chain growth (elongation) and initiation - the addition of the first nucleotide of the DNA chain (dCMP) to the preterminal protein - are inhibited directly by the drug, by not by alpha-amanitin.	Alpha-Amanitin	234-248	cmp	Drosophila melanogaster	153-157
6690454-11	1984	In isolated nuclei, DHFR RNA synthesis is inhibited by alpha-amanitin (1 microgram/ml), indicating that the DHFR gene is transcribed by RNA polymerase II.	Alpha-Amanitin	55-69	dihydrofolate reductase	Mus musculus	20-24
6690454-11	1984	In isolated nuclei, DHFR RNA synthesis is inhibited by alpha-amanitin (1 microgram/ml), indicating that the DHFR gene is transcribed by RNA polymerase II.	Alpha-Amanitin	55-69	dihydrofolate reductase	Mus musculus	108-112
6609159-2	1984	Addition of actinomycin D or alpha-amanitin simultaneously with 1,25-(OH)2D3 prevented hormonal elevation of BGP levels but did not affect basal BGP synthesis.	Alpha-Amanitin	29-43	bone gamma-carboxyglutamate protein	Homo sapiens	109-112
7248303-6	1981	Moreover, actinomycin D and alpha-amanitin inhibited the stimulation of ornithine decarboxylase, showing that the enhanced activity in vitro resulted from the synthesis of new mRNA for ornithine decarboxylase.	Alpha-Amanitin	28-42	ornithine decarboxylase 1	Rattus norvegicus	72-95
6886593-5	1983	Embryo-coded HPRT activity is detectable by the 4- to 8-cell stage when the increase in HPRT activity becomes sensitive to alpha-amanitin.	Alpha-Amanitin	123-137	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	13-17
6886593-5	1983	Embryo-coded HPRT activity is detectable by the 4- to 8-cell stage when the increase in HPRT activity becomes sensitive to alpha-amanitin.	Alpha-Amanitin	123-137	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	88-92
6795031-4	1981	ODC activity and progesterone production also correlated closely after administration of various inhibitors of protein or RNA synthesis [cycloheximide (10 microgram/ml), actinomycin D (1 microgram/ml), or alpha-amanitin (1 microgram/ml)].	Alpha-Amanitin	205-219	ornithine decarboxylase 1	Homo sapiens	0-3
6115471-0	1981	A conjugate of alpha-amanitin and monoclonal immunoglobulin G to Thy 1.2 antigen is selectively toxic to T lymphoma cells.	Alpha-Amanitin	15-29	thymus cell antigen 1, theta	Mus musculus	65-72
6115471-1	1981	A covalent conjugate of an alpha-amanitin azo derivative and a monoclonal immunoglobulin G to the Thy 1.2 antigen on murine T lymphocytes was synthesized.	Alpha-Amanitin	27-41	thymus cell antigen 1, theta	Mus musculus	98-105
6891290-3	1982	Enucleated or alpha-amanitin-injected oocytes synthesize normal levels of heat-shock protein.	Alpha-Amanitin	14-28	heat shock 70kDa protein L homeolog	Xenopus laevis	74-92
6807638-6	1982	Such staining correlates with RNA polymerase II activity as judged by the sensitivity of RNA synthesis at these sites to low concentrations of alpha-amanitin.	Alpha-Amanitin	143-157	RNA polymerase II 215kD subunit	Drosophila melanogaster	30-47
7248303-6	1981	Moreover, actinomycin D and alpha-amanitin inhibited the stimulation of ornithine decarboxylase, showing that the enhanced activity in vitro resulted from the synthesis of new mRNA for ornithine decarboxylase.	Alpha-Amanitin	28-42	ornithine decarboxylase 1	Rattus norvegicus	185-208
95387-9	1979	Using alpha-amanitine and different ionic strength conditions it was found that erythropoietin enhances preferentially RNA polymerase II activity while testosterone increases RNA polymerase I activity.	Alpha-Amanitin	6-21	erythropoietin	Rattus norvegicus	80-94
7193216-4	1980	Cordycepin and alpha-amanitin also prevent dexamethasone-mediated inhibition of PA in HuEL cells, indicating that the RNA whose synthesis must be prevented is of the mRNA class.	Alpha-Amanitin	15-29	solute carrier family 30 member 9	Homo sapiens	86-90
6777048-1	1980	We previously described an alpha-amanitin-resistant mutant of D. melanogaster (AmaC4 or simply C4) with an altered, amanitin-resistant RNA polymerase II.	Alpha-Amanitin	27-41	RNA polymerase II 215kD subunit	Drosophila melanogaster	135-152
6784718-3	1981	Eighty-five percent of the activity in the extracts is inhibited by 1 microgram/ml alpha-amanitin and this fraction is attributed to RNA polymerase II.	Alpha-Amanitin	83-97	RNA polymerase II 140kD subunit	Drosophila melanogaster	133-150
6250695-3	1980	However, the dPyK mRNA synthesis was sensitive to alpha-amanitin in alpha-amanitin sensitive cells and resistant to alpha-amanitin in alpha-amanitin resistant cells.	Alpha-Amanitin	50-64	Pyruvate kinase	Drosophila melanogaster	13-17
6250695-3	1980	However, the dPyK mRNA synthesis was sensitive to alpha-amanitin in alpha-amanitin sensitive cells and resistant to alpha-amanitin in alpha-amanitin resistant cells.	Alpha-Amanitin	68-82	Pyruvate kinase	Drosophila melanogaster	13-17
6250695-3	1980	However, the dPyK mRNA synthesis was sensitive to alpha-amanitin in alpha-amanitin sensitive cells and resistant to alpha-amanitin in alpha-amanitin resistant cells.	Alpha-Amanitin	68-82	Pyruvate kinase	Drosophila melanogaster	13-17
6250695-3	1980	However, the dPyK mRNA synthesis was sensitive to alpha-amanitin in alpha-amanitin sensitive cells and resistant to alpha-amanitin in alpha-amanitin resistant cells.	Alpha-Amanitin	68-82	Pyruvate kinase	Drosophila melanogaster	13-17
6250695-4	1980	The effective dose range of alpha-amanitin used and the genetic lesion in alpha-amanitin resistant cells suggested that cellular DNA-dependent RNA polymerase II was also involved in the transcription of dPyK.	Alpha-Amanitin	28-42	Pyruvate kinase	Drosophila melanogaster	203-207
6250695-4	1980	The effective dose range of alpha-amanitin used and the genetic lesion in alpha-amanitin resistant cells suggested that cellular DNA-dependent RNA polymerase II was also involved in the transcription of dPyK.	Alpha-Amanitin	74-88	Pyruvate kinase	Drosophila melanogaster	203-207
109306-0	1979	alpha-Amanitin: inactivation by bovine lactoperoxidase.	Alpha-Amanitin	0-14	lactoperoxidase	Bos taurus	39-54
109306-1	1979	The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus.	Alpha-Amanitin	24-38	lactoperoxidase	Bos taurus	82-97
109306-2	1979	Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.	Alpha-Amanitin	123-137	lactoperoxidase	Bos taurus	143-158
287014-4	1979	The sensitivity of labeling of the RNA synthesized and released from the nuclei to low doses of alpha-amanitin suggests the presence of polymerase II products in the particles.	Alpha-Amanitin	96-110	RNA polymerase II, I and III subunit F	Rattus norvegicus	136-149
1174142-4	1975	IIa and IIb were inhibited completely by 0.1 mug alpha-amanitin/ml, whereas the other forms were not.	Alpha-Amanitin	49-63	ATPase, class II, type 9A	Mus musculus	0-3
81070-5	1978	Actinomycin D or alpha-amanitin completely blocks the synthesis of alpha2u-globulin RNA in these nuclei.	Alpha-Amanitin	17-31	alpha2u globulin	Rattus norvegicus	67-83
273231-6	1978	The synthesis of ovalbumin RNA progressed during the incubation of nuclei and was sensitive to actinomycin D and low concentrations of alpha-amanitin.	Alpha-Amanitin	135-149	ovalbumin (SERPINB14)	Gallus gallus	17-26
840645-5	1977	Studies with alpha-amanitin showed that both RNA polymerase I and II were stimulated by the estradiol receptor.	Alpha-Amanitin	13-27	estrogen receptor 1	Gallus gallus	92-110
1174142-4	1975	IIa and IIb were inhibited completely by 0.1 mug alpha-amanitin/ml, whereas the other forms were not.	Alpha-Amanitin	49-63	ATPase, class II, type 9B	Mus musculus	8-11
174977-4	1975	Addition of either 0.062 mug/ml actinomycin D or 100 mug/ml cordycepin along with dbT, or 3 mug/ml alpha-amanitin 9 h prior to addition of dbT, prevented the increase in hCG secretion at 3 1/2-8 h. It was concluded that synthesis of RNA (possibly messenger RNA) is required for the early stimulation of hCG secretion by dbT.	Alpha-Amanitin	99-113	chorionic gonadotropin subunit beta 5	Homo sapiens	170-173
174977-4	1975	Addition of either 0.062 mug/ml actinomycin D or 100 mug/ml cordycepin along with dbT, or 3 mug/ml alpha-amanitin 9 h prior to addition of dbT, prevented the increase in hCG secretion at 3 1/2-8 h. It was concluded that synthesis of RNA (possibly messenger RNA) is required for the early stimulation of hCG secretion by dbT.	Alpha-Amanitin	99-113	chorionic gonadotropin subunit beta 5	Homo sapiens	303-306
4656807-5	1972	The early (15min) increase in RNA synthesis in ;high-salt conditions" can be completely eliminated by alpha-amanitin, an inhibitor of the RNA polymerase II.	Alpha-Amanitin	102-116	RNA polymerase II, I and III subunit F	Rattus norvegicus	142-155
4736535-5	1973	Production of H-1 viral protein was shown to be sensitive to inhibition by alpha-amanitin.	Alpha-Amanitin	75-89	H1.5 linker histone, cluster member	Homo sapiens	14-17
11945974-0	1971	Inhibitory effects of alpha-amanitin on RNA synthesis and induction of DOPA-decarboxylase by beta-ecdysone.	Alpha-Amanitin	22-36	dopa decarboxylase	Homo sapiens	71-89
5144225-0	1971	Effect of alpha-amanitin on ribonucleic acid polymerase II of rat brain nuclei and on retention of avoidance conditioning.	Alpha-Amanitin	10-24	RNA polymerase II, I and III subunit F	Rattus norvegicus	45-58
5144225-2	1971	alpha-Amanitin inhibits in vitro the activity of RNA polymerase II of rat brain nuclei.	Alpha-Amanitin	0-14	RNA polymerase II, I and III subunit F	Rattus norvegicus	53-66
31726883-7	2020	Catalase levels increased significantly in the alpha-AMA + SR group, compared to those in the alpha-AMA + NS group (p < 0.001).	Alpha-Amanitin	47-56	catalase	Mus musculus	0-8
4918258-1	1970	alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus.	Alpha-Amanitin	0-14	RNA polymerase II, I and III subunit F	Rattus norvegicus	115-128
32814259-8	2020	The limits of detection for alpha-amanitin and beta-amanitin in plasma were both 0.02 ng mL-1.	Alpha-Amanitin	28-42	L1 cell adhesion molecule	Mus musculus	89-93
33568521-6	2021	Therefore, breast cancer cells with heterozygous loss of 17p are extremely sensitive to the inhibition of POLR2A via a specific small-molecule inhibitor, alpha-amanitin.	Alpha-Amanitin	154-168	RNA polymerase II subunit A	Homo sapiens	106-112
33568521-7	2021	Here, we demonstrate that alpha-amanitin-conjugated trastuzumab (T-Ama) potentiated the HER2-targeted therapy and exhibited superior efficacy in treating HER2-low breast cancer with 17p loss.	Alpha-Amanitin	26-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-92
33660802-8	2021	After alpha-amanitin induction in glioma cells overexpressing LINC00887, RNA degradation of CCND1 was examined at 0, 6, 12 and 24 h, respectively.	Alpha-Amanitin	6-20	long intergenic non-protein coding RNA 887	Homo sapiens	62-71
31270214-7	2019	When the transcription was inhibited by alpha-amanitin, the degradation of CAR mRNA was attenuated by knockdown of ADAR1, suggesting that the increase in CAR mRNA level by ADAR1 knockdown is a post-transcriptional event.	Alpha-Amanitin	40-54	nuclear receptor subfamily 1 group I member 3	Homo sapiens	75-78
31696483-7	2019	At last, the mRNA level of UPF1 was determined in U87 and LN229 cells overexpressing PVT1 treated with 50 muM alpha-amanitin.	Alpha-Amanitin	110-124	UPF1 RNA helicase and ATPase	Homo sapiens	27-31
31696483-7	2019	At last, the mRNA level of UPF1 was determined in U87 and LN229 cells overexpressing PVT1 treated with 50 muM alpha-amanitin.	Alpha-Amanitin	110-124	Pvt1 oncogene	Homo sapiens	85-89
31504820-8	2019	Blastomere patterns of Cops3 mRNA distribution are alpha-amanitin-resistant.	Alpha-Amanitin	51-65	COP9 signalosome subunit 3	Mus musculus	23-28
31270214-7	2019	When the transcription was inhibited by alpha-amanitin, the degradation of CAR mRNA was attenuated by knockdown of ADAR1, suggesting that the increase in CAR mRNA level by ADAR1 knockdown is a post-transcriptional event.	Alpha-Amanitin	40-54	adenosine deaminase RNA specific	Homo sapiens	115-120
31270214-7	2019	When the transcription was inhibited by alpha-amanitin, the degradation of CAR mRNA was attenuated by knockdown of ADAR1, suggesting that the increase in CAR mRNA level by ADAR1 knockdown is a post-transcriptional event.	Alpha-Amanitin	40-54	nuclear receptor subfamily 1 group I member 3	Homo sapiens	154-157
31270214-7	2019	When the transcription was inhibited by alpha-amanitin, the degradation of CAR mRNA was attenuated by knockdown of ADAR1, suggesting that the increase in CAR mRNA level by ADAR1 knockdown is a post-transcriptional event.	Alpha-Amanitin	40-54	adenosine deaminase RNA specific	Homo sapiens	172-177
31123282-0	2019	BRAF inhibition sensitizes melanoma cells to alpha-amanitin via decreased RNA polymerase II assembly.	Alpha-Amanitin	45-59	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
31244217-5	2019	We produced a conjugate of FGF2 with either monomethyl auristatin E (MMAE) or alpha-amanitin (alphaAMTN) as a cytotoxic agent and subsequently applied a sortase A-mediated ligation to obtain a dimeric conjugate containing both MMAE and alphaAMTN.	Alpha-Amanitin	78-92	fibroblast growth factor 2	Homo sapiens	27-31
31244217-5	2019	We produced a conjugate of FGF2 with either monomethyl auristatin E (MMAE) or alpha-amanitin (alphaAMTN) as a cytotoxic agent and subsequently applied a sortase A-mediated ligation to obtain a dimeric conjugate containing both MMAE and alphaAMTN.	Alpha-Amanitin	94-103	fibroblast growth factor 2	Homo sapiens	27-31
30890736-10	2019	However, forced transcriptional shutdown using transcriptional inhibitors alpha-amanitin and 5,6-dichloro-1-ss-D-ribofuranosylbenzimidazole (DRB) slowed down DSB repair and resensitized TLP-knockdown cells to etoposide.	Alpha-Amanitin	74-88	TATA-box binding protein like 1	Homo sapiens	186-189
30891624-3	2019	Previously, we have shown that polymyxin B (polB) reverts alpha-amanitin inhibition of RNAPII, although it was not able to guarantee the full survival of alpha-amanitin-intoxicated mice or prevent alpha-amanitin pro-inflammatory effects.	Alpha-Amanitin	58-72	polymerase (DNA directed), beta	Mus musculus	31-42
30891624-3	2019	Previously, we have shown that polymyxin B (polB) reverts alpha-amanitin inhibition of RNAPII, although it was not able to guarantee the full survival of alpha-amanitin-intoxicated mice or prevent alpha-amanitin pro-inflammatory effects.	Alpha-Amanitin	58-72	polymerase (DNA directed), beta	Mus musculus	44-48
30891624-4	2019	alpha-Amanitin is also a substrate of the organic-anion-transporting polypeptide 1B3 (OATP1B3) and Na(+)-taurocholate cotransporter polypeptide (NTCP) transporters.	Alpha-Amanitin	0-14	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	99-143
30891624-4	2019	alpha-Amanitin is also a substrate of the organic-anion-transporting polypeptide 1B3 (OATP1B3) and Na(+)-taurocholate cotransporter polypeptide (NTCP) transporters.	Alpha-Amanitin	0-14	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	145-149
30891624-9	2019	Results showed that the administration of the polB + MP combination, 4 h after alpha-amanitin, led to the full survival of the intoxicated animals, with a significant attenuation of alpha-amanitin-induced renal and hepatic necrosis.	Alpha-Amanitin	79-93	DNA polymerase beta	Homo sapiens	46-50
30891624-9	2019	Results showed that the administration of the polB + MP combination, 4 h after alpha-amanitin, led to the full survival of the intoxicated animals, with a significant attenuation of alpha-amanitin-induced renal and hepatic necrosis.	Alpha-Amanitin	182-196	DNA polymerase beta	Homo sapiens	46-50
30891624-10	2019	Also, the combination polB + MP led to a decrease of aminotransferase plasma levels, of the renal myeloperoxidase activity and of renal inflammatory cell infiltrate promoted by alpha-amanitin, although not preventing any of the hepatic pro-inflammatory effect of the toxin.	Alpha-Amanitin	177-191	DNA polymerase beta	Homo sapiens	22-26
30896385-7	2019	Treatment of cells from one viraemic patient with alpha-amanitin greatly reduces the rate of ASP RNA synthesis, suggesting that it is associated with RNA polymerase II, the central enzyme in the transcription of protein-coding genes.	Alpha-Amanitin	50-64	assembly factor for spindle microtubules	Homo sapiens	93-96
30891624-0	2019	An effective antidotal combination of polymyxin B and methylprednisolone for alpha-amanitin intoxication.	Alpha-Amanitin	77-91	DNA polymerase beta	Homo sapiens	38-49
30349055-5	2018	Combined inhibition of RNAP2 and RBX1 profoundly suppress the growth of CRPC in a synergistic manner, which potentiates the therapeutic effectivity of the RNAP2 inhibitor, alpha-amanitin-based antibody drug conjugate (ADC).	Alpha-Amanitin	172-186	ring-box 1	Homo sapiens	33-37
28823811-9	2018	alpha-Amanitin insensitivity confirmed that overexpression of miR-4443 was not due to transcriptional activation.	Alpha-Amanitin	0-14	microRNA 4443	Homo sapiens	62-70
30029518-0	2018	FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and alpha-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1.	Alpha-Amanitin	61-75	fibroblast growth factor 2	Homo sapiens	0-4
30029518-0	2018	FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and alpha-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1.	Alpha-Amanitin	61-75	fibroblast growth factor receptor 1	Homo sapiens	139-153
30029518-2	2018	We developed a fibroblast growth factor 2 (FGF2)-conjugate bearing two cytotoxic drugs with independent mode of action: alpha-amanitin and monomethyl auristatin E.	Alpha-Amanitin	120-134	fibroblast growth factor 2	Homo sapiens	15-41
30029518-2	2018	We developed a fibroblast growth factor 2 (FGF2)-conjugate bearing two cytotoxic drugs with independent mode of action: alpha-amanitin and monomethyl auristatin E.	Alpha-Amanitin	120-134	fibroblast growth factor 2	Homo sapiens	43-47
29520305-4	2018	In the U87, in the MDA-MB-468, and partly in the A549 cancer cell lines, the cyclo[DKP-isoDGR]-alpha-amanitin conjugates bearing the lysosomally cleavable Val-Ala linker were found to be slightly more potent than alpha-amanitin.	Alpha-Amanitin	95-109	small nucleolar RNA, C/D box 87	Homo sapiens	7-10
29441192-5	2018	To verify the hypothesis that MAPT-AS1 and MAPT might form a duplex structure, we performed RT-PCR assays on RNA after alpha-amanitin treatment.	Alpha-Amanitin	119-133	MAPT antisense RNA 1	Homo sapiens	30-38
29441192-5	2018	To verify the hypothesis that MAPT-AS1 and MAPT might form a duplex structure, we performed RT-PCR assays on RNA after alpha-amanitin treatment.	Alpha-Amanitin	119-133	microtubule associated protein tau	Homo sapiens	30-34
30138934-6	2018	The EGFR mRNA stability was explored by using RNA synthesis inhibitor alpha-amanitin.	Alpha-Amanitin	70-84	epidermal growth factor receptor	Homo sapiens	4-8