PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34516632-3 2022 Gata2 +9.5 deficiency removes the E-box motif and the GATA site and depletes fetal liver HSCs. gata 54-58 GATA binding protein 2 Homo sapiens 0-5 32645737-10 2020 In conclusion, these findings suggest that cacao bean polyphenols prevent pressure overload-induced cardiac hypertrophy and systolic dysfunction by inhibiting the extracellular signal-regulated kinase 1/2-GATA binding protein 4 pathway in cardiomyocytes. gata 205-209 brain expressed, associated with Nedd4, 1 Mus musculus 49-53 35500030-0 2022 The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo. gata 39-43 Transcription factor elt-1 Caenorhabditis elegans 33-38 35500030-0 2022 The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo. gata 39-43 Homeobox protein nob-1 Caenorhabditis elegans 77-82 35500030-0 2022 The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo. gata 39-43 Homeobox protein php-3 Caenorhabditis elegans 87-92 2535536-0 1989 ASF-2: a factor that binds to the cauliflower mosaic virus 35S promoter and a conserved GATA motif in Cab promoters. gata 88-92 neural proliferation, differentiation and control 1 Homo sapiens 102-105 33624780-3 2021 Here, we show that mutations in the putative GATA-binding sites of the AVT4 promoter reduced AVT4 expression. gata 45-49 Avt4p Saccharomyces cerevisiae S288C 71-75 33624780-3 2021 Here, we show that mutations in the putative GATA-binding sites of the AVT4 promoter reduced AVT4 expression. gata 45-49 Avt4p Saccharomyces cerevisiae S288C 93-97 30523150-6 2019 ChIP results indicated that the TMG treatment decreases the occupancy of GATA-1, OGT, and OGA at the GATA-binding site of the lysosomal protein transmembrane 5 (Laptm5) gene promoter. gata 73-77 lysosomal protein transmembrane 5 Homo sapiens 126-159 32823905-6 2020 The rs311103C disrupts the GATA-binding site, resulting in decreased CD99 expression. gata 27-31 CD99 molecule (Xg blood group) Homo sapiens 69-73 31440221-8 2019 This response is mainly regulated by a GATA transcription factor, most likely ELT-2, as indicated by the enrichment of (i) the GATA motif in the promoter regions of inducible genes and (ii) of ELT-2 targets among the differentially expressed genes. gata 39-43 Transcription factor elt-2 Caenorhabditis elegans 78-83 31440221-8 2019 This response is mainly regulated by a GATA transcription factor, most likely ELT-2, as indicated by the enrichment of (i) the GATA motif in the promoter regions of inducible genes and (ii) of ELT-2 targets among the differentially expressed genes. gata 39-43 Transcription factor elt-2 Caenorhabditis elegans 193-198 30818362-4 2019 Our data reveal Dal80 binding to a large set of promoters, sometimes independently of GATA sites, correlating with nitrogen- and/or Dal80-sensitive gene expression. gata 86-90 Dal80p Saccharomyces cerevisiae S288C 132-137 33073934-11 2020 In addition, the patient 3 who harboring missense variants in the GATA binding domain of TRPS1 showed more severe craniofacial and skeletal phenotypes. gata 66-70 transcriptional repressor GATA binding 1 Homo sapiens 89-94 31520575-6 2019 AR binding sites (ARBS) are enriched for FOX, HOX, and GATA motifs in PC cells but not for c-JUN motifs in benign cells. gata 55-59 androgen receptor Homo sapiens 0-2 30914275-8 2019 Our findings, in addition to identifying the genetic cause of brachydactyly in two unrelated kindreds, emphasize the role of pathogenic TRPS1 variants in the development of brachydactyly type E and highlight the GATA DNA-binding region of TRPS1 protein with respect to phenotype-genotype correlation. gata 212-216 transcriptional repressor GATA binding 1 Homo sapiens 239-244 30523150-6 2019 ChIP results indicated that the TMG treatment decreases the occupancy of GATA-1, OGT, and OGA at the GATA-binding site of the lysosomal protein transmembrane 5 (Laptm5) gene promoter. gata 73-77 lysosomal protein transmembrane 5 Homo sapiens 161-167 29550363-5 2018 In the present study, we revealed the dynamics of Gata.a and beta-catenin, and expression profiles of their target genes precisely. gata 50-54 beta-catenin Ciona intestinalis 61-73 30315105-5 2018 Mechanistically, TRPS1 repressed SOX2 expression by directly targeting the consensus GATA-binding element in the SOX2 promoter as elucidated by ChIP and luciferase reporter assays. gata 85-89 transcriptional repressor GATA binding 1 Mus musculus 17-22 30315105-5 2018 Mechanistically, TRPS1 repressed SOX2 expression by directly targeting the consensus GATA-binding element in the SOX2 promoter as elucidated by ChIP and luciferase reporter assays. gata 85-89 SRY (sex determining region Y)-box 2 Mus musculus 33-37 30315105-5 2018 Mechanistically, TRPS1 repressed SOX2 expression by directly targeting the consensus GATA-binding element in the SOX2 promoter as elucidated by ChIP and luciferase reporter assays. gata 85-89 SRY (sex determining region Y)-box 2 Mus musculus 113-117 30510588-6 2018 Additionally, DNA methylation was also altered by TCS exposure, especially in those regions with GATA motif enrichment. gata 97-101 treacle ribosome biogenesis factor 1 Homo sapiens 50-53 29991720-7 2018 We demonstrate that RUNX1 induction moves FLI1 from distal ETS/GATA sites to RUNX1/ETS sites and recruits the basal transcription factors CDK9, BRD4, the Mediator complex and the looping factor LDB1. gata 63-67 runt related transcription factor 1 Mus musculus 20-25 29991720-7 2018 We demonstrate that RUNX1 induction moves FLI1 from distal ETS/GATA sites to RUNX1/ETS sites and recruits the basal transcription factors CDK9, BRD4, the Mediator complex and the looping factor LDB1. gata 63-67 Friend leukemia integration 1 Mus musculus 42-46 29991720-7 2018 We demonstrate that RUNX1 induction moves FLI1 from distal ETS/GATA sites to RUNX1/ETS sites and recruits the basal transcription factors CDK9, BRD4, the Mediator complex and the looping factor LDB1. gata 63-67 cyclin-dependent kinase 9 (CDC2-related kinase) Mus musculus 138-142 29991720-7 2018 We demonstrate that RUNX1 induction moves FLI1 from distal ETS/GATA sites to RUNX1/ETS sites and recruits the basal transcription factors CDK9, BRD4, the Mediator complex and the looping factor LDB1. gata 63-67 bromodomain containing 4 Mus musculus 144-148 29991720-7 2018 We demonstrate that RUNX1 induction moves FLI1 from distal ETS/GATA sites to RUNX1/ETS sites and recruits the basal transcription factors CDK9, BRD4, the Mediator complex and the looping factor LDB1. gata 63-67 LIM domain binding 1 Mus musculus 194-198 29197504-5 2018 Both sequences contain GATA binding motifs, and expression pattern analysis identified that Gata6 is expressed in the flank and the anterior portion of nascent hindlimb buds. gata 23-27 GATA binding protein 6 Mus musculus 92-97 29263149-7 2018 We also demonstrate that Pdx1 expression in adult beta-cells depends on GATA sites in transgenic reporter mice and that loss of GATA6 greatly affects beta-cell-specific gene expression. gata 72-76 pancreatic and duodenal homeobox 1 Mus musculus 25-29 29564399-6 2018 For example, the core GATA activators GAT1 and GLN3 have a conserved role in nitrogen catabolite repression (NCR). gata 22-26 Gat1p Saccharomyces cerevisiae S288C 38-42 29564399-6 2018 For example, the core GATA activators GAT1 and GLN3 have a conserved role in nitrogen catabolite repression (NCR). gata 22-26 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 47-51 28082341-8 2017 Chromatin immunoprecipitation sequencing revealed 5 GATA binding sites in a regulatory region 31 kb upstream of NBEAL2 covered by a H3K4Me1 mark indicative of an enhancer locus. gata 52-56 neurobeachin like 2 Homo sapiens 112-118 29299165-11 2017 Chromatin immunoprecipitation (ChIP) assays validated that GATA3 binds directly to the +220 GATA binding motif on the human vWF promoter and A549 conditioned media significantly increases the binding of GATA3. gata 59-63 von Willebrand factor Homo sapiens 124-127 29299165-11 2017 Chromatin immunoprecipitation (ChIP) assays validated that GATA3 binds directly to the +220 GATA binding motif on the human vWF promoter and A549 conditioned media significantly increases the binding of GATA3. gata 59-63 GATA binding protein 3 Homo sapiens 203-208 28216155-6 2017 Promoter analysis and quantitative ChIP analysis demonstrated that FOG1-mediated transcriptional repression of PU.1 would be mediated through a GATA-binding element located at its promoter, accompanied by significantly decreased H3 acetylation at lysine 4 and 9 (K4 and K9) as well as H3K4 trimethylation. gata 144-148 zinc finger protein, FOG family member 1 Homo sapiens 67-71 28216155-6 2017 Promoter analysis and quantitative ChIP analysis demonstrated that FOG1-mediated transcriptional repression of PU.1 would be mediated through a GATA-binding element located at its promoter, accompanied by significantly decreased H3 acetylation at lysine 4 and 9 (K4 and K9) as well as H3K4 trimethylation. gata 144-148 Spi-1 proto-oncogene Homo sapiens 111-115 29035278-5 2017 In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and recruited Hdac3 to the evolutionarily conserved E-box-GATA-ETS composite element of a Gata2 intragenic enhancer. gata 176-180 T cell acute lymphocytic leukemia 1 Mus musculus 67-71 29035278-5 2017 In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and recruited Hdac3 to the evolutionarily conserved E-box-GATA-ETS composite element of a Gata2 intragenic enhancer. gata 176-180 GATA binding protein 2 Mus musculus 73-78 29035278-5 2017 In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and recruited Hdac3 to the evolutionarily conserved E-box-GATA-ETS composite element of a Gata2 intragenic enhancer. gata 176-180 E26 avian leukemia oncogene 1, 5' domain Mus musculus 84-88 29035278-5 2017 In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and recruited Hdac3 to the evolutionarily conserved E-box-GATA-ETS composite element of a Gata2 intragenic enhancer. gata 176-180 histone deacetylase 3 Mus musculus 132-137 29035278-5 2017 In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and recruited Hdac3 to the evolutionarily conserved E-box-GATA-ETS composite element of a Gata2 intragenic enhancer. gata 176-180 GATA binding protein 2 Mus musculus 208-213 28982936-6 2017 The AP1 site also serves as a GATA-binding site in one of the bovine IFNT genes. gata 30-34 Jun proto-oncogene, AP-1 transcription factor subunit Bos taurus 4-7 28982936-6 2017 The AP1 site also serves as a GATA-binding site in one of the bovine IFNT genes. gata 30-34 interferon-tau 3g Bos taurus 69-73 28007891-1 2017 Nitrogen catabolite repression (NCR), the ability of Saccharomyces cerevisiae to use good nitrogen sources in preference to poor ones, derives from nitrogen-responsive regulation of the GATA family transcription activators Gln3 and Gat1 In nitrogen-replete conditions, the GATA factors are cytoplasmic and NCR-sensitive transcription minimal. gata 186-190 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 223-227 27746176-7 2017 These data suggest that GATA factor could affect G protein signaling through regulating RGS4 expression, and GATA signaling may develop as a future therapeutic target for RGS4-related diseases. gata 24-28 regulator of G-protein signaling 4 Oryctolagus cuniculus 88-92 27746176-7 2017 These data suggest that GATA factor could affect G protein signaling through regulating RGS4 expression, and GATA signaling may develop as a future therapeutic target for RGS4-related diseases. gata 24-28 regulator of G-protein signaling 4 Oryctolagus cuniculus 171-175 28007891-1 2017 Nitrogen catabolite repression (NCR), the ability of Saccharomyces cerevisiae to use good nitrogen sources in preference to poor ones, derives from nitrogen-responsive regulation of the GATA family transcription activators Gln3 and Gat1 In nitrogen-replete conditions, the GATA factors are cytoplasmic and NCR-sensitive transcription minimal. gata 186-190 Gat1p Saccharomyces cerevisiae S288C 232-236 28007891-1 2017 Nitrogen catabolite repression (NCR), the ability of Saccharomyces cerevisiae to use good nitrogen sources in preference to poor ones, derives from nitrogen-responsive regulation of the GATA family transcription activators Gln3 and Gat1 In nitrogen-replete conditions, the GATA factors are cytoplasmic and NCR-sensitive transcription minimal. gata 273-277 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 223-227 28007891-1 2017 Nitrogen catabolite repression (NCR), the ability of Saccharomyces cerevisiae to use good nitrogen sources in preference to poor ones, derives from nitrogen-responsive regulation of the GATA family transcription activators Gln3 and Gat1 In nitrogen-replete conditions, the GATA factors are cytoplasmic and NCR-sensitive transcription minimal. gata 273-277 Gat1p Saccharomyces cerevisiae S288C 232-236 27231347-1 2016 One mode of gamma-globin gene silencing involves a GATA-1 FOG-1 Mi2beta repressor complex that binds to the -566 GATA site relative to the (A)gamma-globin gene cap site. gata 51-55 chromodomain helicase DNA binding protein 4 Homo sapiens 64-71 28123038-0 2017 Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation. gata 9-13 aminolevulinic acid synthase 2, erythroid Mus musculus 28-33 28123038-1 2017 The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggesting it could be causal mutations of XLSA. gata 45-49 wingless-type MMTV integration site family, member 1 Mus musculus 56-61 28123038-1 2017 The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggesting it could be causal mutations of XLSA. gata 45-49 aminolevulinic acid synthase 2, erythroid Mus musculus 71-99 28123038-1 2017 The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggesting it could be causal mutations of XLSA. gata 45-49 aminolevulinic acid synthase 2, erythroid Mus musculus 101-106 28123038-2 2017 However, the function of this int-1-GATA site during in vivo development remains largely unknown. gata 36-40 wingless-type MMTV integration site family, member 1 Mus musculus 30-35 27231347-7 2016 Taken together, our data suggest that O-GlcNAcylation is a novel mechanism of gamma-globin gene regulation mediated by modulating the assembly of the GATA-1 FOG-1 Mi2beta repressor complex at the -566 GATA motif within the promoter. gata 150-154 zinc finger protein, FOG family member 1 Homo sapiens 157-162 27231347-7 2016 Taken together, our data suggest that O-GlcNAcylation is a novel mechanism of gamma-globin gene regulation mediated by modulating the assembly of the GATA-1 FOG-1 Mi2beta repressor complex at the -566 GATA motif within the promoter. gata 150-154 chromodomain helicase DNA binding protein 4 Homo sapiens 163-170 27231347-1 2016 One mode of gamma-globin gene silencing involves a GATA-1 FOG-1 Mi2beta repressor complex that binds to the -566 GATA site relative to the (A)gamma-globin gene cap site. gata 51-55 hemoglobin subunit gamma 1 Homo sapiens 140-154 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 69-77 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 99-107 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 121-124 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-GlcNAcase Homo sapiens 130-141 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-GlcNAcase Homo sapiens 143-146 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 hemoglobin subunit gamma 1 Homo sapiens 168-182 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 290-293 27231347-3 2016 In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in beta-globin locus yeast artificial chromosome (beta-YAC) bone marrow cells. gata 204-208 O-GlcNAcase Homo sapiens 298-301 27152625-7 2016 Third, Gata.a directs specific gene expression in the animal hemisphere domain, because beta-catenin/Tcf7 weakens the Gata.a-binding activity for target sites through a physical interaction in the vegetal cells. gata 7-11 beta-catenin Ciona intestinalis 88-100 27079877-6 2016 Using a combination of targeted mutagenesis of transcription factor-binding sites and gene silencing of transcription factors, we found that Gata and Ets factors are required for Flk1in10 enhancer activity in all endothelial cells. gata 141-145 kinase insert domain protein receptor Mus musculus 179-183 27340386-2 2016 The regulatory sequence of the CCR3 gene, contains two Runt-related transcription factor (RUNX) 1 sites and two PU.1 sites, in addition to a functional GATA site for transactivation of the CCR3 gene. gata 152-156 C-C motif chemokine receptor 3 Homo sapiens 31-35 27340386-2 2016 The regulatory sequence of the CCR3 gene, contains two Runt-related transcription factor (RUNX) 1 sites and two PU.1 sites, in addition to a functional GATA site for transactivation of the CCR3 gene. gata 152-156 C-C motif chemokine receptor 3 Homo sapiens 189-193 27152625-7 2016 Third, Gata.a directs specific gene expression in the animal hemisphere domain, because beta-catenin/Tcf7 weakens the Gata.a-binding activity for target sites through a physical interaction in the vegetal cells. gata 118-122 beta-catenin Ciona intestinalis 88-100 26896592-0 2016 Mutagenesis of GATA motifs controlling the endoderm regulator elt-2 reveals distinct dominant and secondary cis-regulatory elements. gata 15-19 Transcription factor elt-2 Caenorhabditis elegans 62-67 26896592-5 2016 We determined that a single primary dominant GATA motif located 527bp upstream of the elt-2 start codon was necessary for both embryonic activation and later maintenance of transcription, while nearby secondary GATA motifs played largely subtle roles in modulating postembryonic levels of elt-2. gata 45-49 Transcription factor elt-2 Caenorhabditis elegans 86-91 25938608-7 2015 In 293T gel shift assays, exogenous C/EBPalpha binds both C/EBP sites, c-Myb binds the Myb site, PU.1 binds the second Ets site, PU.1, Fli-1, ERG, and Ets1 bind the sixth Ets site, GATA2 binds both GATA sites, and SCL binds the second E-box. gata 181-185 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 36-46 26932670-6 2016 Consistent with the erroneous activation of hedgehog signaling, we demonstrate that GATA4 and GATA6 are able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 and that GATA-binding sites within this enhancer are necessary for this repressive activity. gata 84-88 sonic hedgehog signaling molecule Homo sapiens 146-160 26932670-6 2016 Consistent with the erroneous activation of hedgehog signaling, we demonstrate that GATA4 and GATA6 are able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 and that GATA-binding sites within this enhancer are necessary for this repressive activity. gata 84-88 sonic hedgehog signaling molecule Homo sapiens 162-165 26932670-6 2016 Consistent with the erroneous activation of hedgehog signaling, we demonstrate that GATA4 and GATA6 are able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 and that GATA-binding sites within this enhancer are necessary for this repressive activity. gata 84-88 acyl-CoA synthetase medium chain family member 1 Homo sapiens 194-199 25825272-8 2015 Claudin-2 has hyperosmolarity-sensitive region in its promoter, which includes GATA binding site. gata 79-83 claudin 2 Canis lupus familiaris 0-9 26601269-3 2015 Mutation of an intronic GATA motif (+9.5) in GATA2, encoding a master regulator of hematopoiesis, underlies an immunodeficiency associated with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). gata 24-28 GATA binding protein 2 Mus musculus 45-50 26183398-3 2015 We identified TRPS1 (tricho-rhino-phalangeal-syndrome 1), a repressor of GATA-mediated transcription, and BAT3 (Scythe/BAG6), a nucleo-cytoplasmic shuttling chaperone protein, as new Cath-D-interacting nuclear proteins. gata 73-77 transcriptional repressor GATA binding 1 Homo sapiens 21-55 25938608-7 2015 In 293T gel shift assays, exogenous C/EBPalpha binds both C/EBP sites, c-Myb binds the Myb site, PU.1 binds the second Ets site, PU.1, Fli-1, ERG, and Ets1 bind the sixth Ets site, GATA2 binds both GATA sites, and SCL binds the second E-box. gata 181-185 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 36-41 24018543-0 2013 GATA augments GNRH-mediated increases in Adcyap1 gene expression in pituitary gonadotrope cells. gata 0-4 gonadotropin releasing hormone 1 Rattus norvegicus 14-18 25552417-9 2015 Of note, PIAS1 depletion affected AR chromatin occupancy at binding sites enriched for HOXD13 and GATA motifs. gata 98-102 protein inhibitor of activated STAT 1 Homo sapiens 9-14 25552417-9 2015 Of note, PIAS1 depletion affected AR chromatin occupancy at binding sites enriched for HOXD13 and GATA motifs. gata 98-102 androgen receptor Homo sapiens 34-36 25429295-8 2014 This common regulatory framework comprises a composite box made of the GATA motifs and GCN4-like Motifs (GLMs) and was shown to be functional as the GLMs are able to bind a bZIP transcriptional factor SPA (Storage Protein Activator). gata 71-75 bZIP transcription factor RISBZ2 Triticum aestivum 201-204 25429295-8 2014 This common regulatory framework comprises a composite box made of the GATA motifs and GCN4-like Motifs (GLMs) and was shown to be functional as the GLMs are able to bind a bZIP transcriptional factor SPA (Storage Protein Activator). gata 71-75 bZIP transcription factor RISBZ2 Triticum aestivum 206-231 24166784-0 2014 X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations. gata 69-73 5'-aminolevulinate synthase 2 Homo sapiens 37-42 25675838-6 2015 Additionally, we found evidence of interspecies variation in binding sites for several regulatory elements linked to iNOS (GATA-3, GATA-4, KLF6, SRF, STAT-1, STAT-3, OLF-1 and HIF-1) across species, especially in African green monkeys relative to other species. gata 123-127 nitric oxide synthase 2 Macaca mulatta 117-121 25711168-8 2015 Finally, we provide evidence that col-41 expression is controlled by a sequence element containing two GATA sites and by the epidermal GATA transcription factors ELT-1 and ELT-3. gata 103-107 Col_cuticle_N domain-containing protein Caenorhabditis elegans 34-40 26430560-0 2015 The C. elegans embryonic fate specification factor EGL-18 (GATA) is reutilized downstream of Wnt signaling to maintain a population of larval progenitor cells. gata 59-63 GATA-type domain-containing protein Caenorhabditis elegans 51-57 24636993-7 2014 We introduced biotin-tagged GATA2 into a mouse CD-derived cell line and conducted chromatin pulldown assays, which revealed direct GATA2 binding to conserved GATA motifs in the Aqp2 promoter region. gata 28-32 GATA binding protein 2 Mus musculus 131-136 24636993-7 2014 We introduced biotin-tagged GATA2 into a mouse CD-derived cell line and conducted chromatin pulldown assays, which revealed direct GATA2 binding to conserved GATA motifs in the Aqp2 promoter region. gata 28-32 aquaporin 2 Mus musculus 177-181 24636993-8 2014 A luciferase reporter assay using an Aqp2 promoter-reporter showed that GATA2 trans activates Aqp2 through the GATA motifs. gata 72-76 aquaporin 2 Mus musculus 37-41 24636993-8 2014 A luciferase reporter assay using an Aqp2 promoter-reporter showed that GATA2 trans activates Aqp2 through the GATA motifs. gata 72-76 aquaporin 2 Mus musculus 94-98 23935018-6 2014 Importantly, two mutations, each of which disrupts the GATA-binding site in the enhancer, were identified in unrelated male patients with congenital sideroblastic anemia, and the lower expression level of ALAS2 mRNA in bone marrow erythroblasts was confirmed in one of these patients. gata 55-59 5'-aminolevulinate synthase 2 Homo sapiens 205-210 24018543-0 2013 GATA augments GNRH-mediated increases in Adcyap1 gene expression in pituitary gonadotrope cells. gata 0-4 adenylate cyclase activating polypeptide 1 Rattus norvegicus 41-48 24018543-5 2013 By transient transfection and electrophoretic mobility shift assay analysis, we demonstrate that GATA2 and GATA4 stimulate Adcyap1 promoter activity via a GATA cis-element located at position -191 in the rat Adcyap1 gene promoter. gata 97-101 adenylate cyclase activating polypeptide 1 Rattus norvegicus 123-130 24021675-8 2013 The 3.2-kb sequences interspaced between the Gata1 hematopoietic enhancer and the double GATA-motif were able to recruit DNA methyltransferase 1, thereby exerting a cis-repressive function in the HSC-like cell line. gata 89-93 GATA binding protein 1 Homo sapiens 45-50 24021675-8 2013 The 3.2-kb sequences interspaced between the Gata1 hematopoietic enhancer and the double GATA-motif were able to recruit DNA methyltransferase 1, thereby exerting a cis-repressive function in the HSC-like cell line. gata 89-93 DNA methyltransferase 1 Homo sapiens 121-144 24018543-5 2013 By transient transfection and electrophoretic mobility shift assay analysis, we demonstrate that GATA2 and GATA4 stimulate Adcyap1 promoter activity via a GATA cis-element located at position -191 in the rat Adcyap1 gene promoter. gata 97-101 adenylate cyclase activating polypeptide 1 Rattus norvegicus 208-215 24018543-7 2013 Conversely, blunting GATA expression with specific siRNA inhibits the ability of GNRH to stimulate ADCYAP1 mRNA levels in these cells. gata 21-25 gonadotropin releasing hormone 1 Rattus norvegicus 81-85 24018543-7 2013 Conversely, blunting GATA expression with specific siRNA inhibits the ability of GNRH to stimulate ADCYAP1 mRNA levels in these cells. gata 21-25 adenylate cyclase activating polypeptide 1 Rattus norvegicus 99-106 24006283-8 2013 Mutation studies identified the minimal region conferring basal and forskolin-stimulated VNN2 promoter activities, which were dependent on chicken ovalbumin upstream promoter-transcription factor (COUP-TF), GATA, and Ebox cis-elements. gata 207-211 vanin 2 Gallus gallus 89-93 24112087-9 2013 Site-directed mutagenesis in transcription-factor-binding sites, including Ets, GATA, and AP2, verified their key roles in regulating transcription, especially sites Ets (-103), GATA (-211), and AP2 (-3). gata 80-84 transcription factor AP-2 beta Sus scrofa 195-198 24112087-9 2013 Site-directed mutagenesis in transcription-factor-binding sites, including Ets, GATA, and AP2, verified their key roles in regulating transcription, especially sites Ets (-103), GATA (-211), and AP2 (-3). gata 178-182 transcription factor AP-2 beta Sus scrofa 90-93 23874392-4 2013 The promoter region of SLCO4C1 gene has several GATA motifs, and indoxyl sulfate up-regulated GATA3 mRNA and subsequently down-regulated SLCO4C1 mRNA. gata 48-52 solute carrier organic anion transporter family, member 4C1 Rattus norvegicus 23-30 23183747-3 2013 A potentially functional polymorphism (i.e., rs4938723T/C) in the promoter region of pri-miR-34b/c was predicted to influence the GATA-X binding sites. gata 130-134 microRNA 34b Homo sapiens 89-96 23717578-5 2013 Runx1 occupied genomic regions were highly enriched in RUNX and ETS motifs and to a lesser extent in GATA motif. gata 101-105 runt related transcription factor 1 Mus musculus 0-5 23211524-9 2013 The trans-repressive action of GATA2 on Gnrhr promoter activity is likely balanced or even hindered by trans-activating effects of LIM homeodomain proteins via this novel bifunctional LIM/GATA response element. gata 31-35 gonadotropin releasing hormone receptor Mus musculus 40-45 23325760-3 2013 Many of the identified Notch-regulated enhancers contain Runx and GATA motifs, and we demonstrate that binding of the Runx protein Lozenge (Lz) is required for enhancers to be competent to respond to Notch. gata 66-70 Notch Drosophila melanogaster 23-28 23325760-3 2013 Many of the identified Notch-regulated enhancers contain Runx and GATA motifs, and we demonstrate that binding of the Runx protein Lozenge (Lz) is required for enhancers to be competent to respond to Notch. gata 66-70 lozenge Drosophila melanogaster 131-138 23325760-3 2013 Many of the identified Notch-regulated enhancers contain Runx and GATA motifs, and we demonstrate that binding of the Runx protein Lozenge (Lz) is required for enhancers to be competent to respond to Notch. gata 66-70 Notch Drosophila melanogaster 200-205 23085565-6 2012 Moreover, we determined the effect of tanshinone IIA on IRF-1 or GATAs induction and binding activity to VCAM-1 promoter since the upstream promoter region of VCAM-1 but not ICAM-1 contains IRF-1 and GATA binding motifs. gata 65-69 vascular cell adhesion molecule 1 Homo sapiens 159-165 22996659-3 2012 Though the disease-causing mutations commonly occur in the GATA-2 DNA binding domain, we identified a patient with mycobacterial infection and myelodysplasia who had an uncharacterized heterozygous deletion in a GATA2 cis-element consisting of an E-box and a GATA motif. gata 59-63 GATA binding protein 2 Homo sapiens 212-217 22996659-3 2012 Though the disease-causing mutations commonly occur in the GATA-2 DNA binding domain, we identified a patient with mycobacterial infection and myelodysplasia who had an uncharacterized heterozygous deletion in a GATA2 cis-element consisting of an E-box and a GATA motif. gata 59-63 cytokine inducible SH2 containing protein Homo sapiens 218-221 22420414-7 2012 Consistent with their expression patterns during chick embryonic development, Gata4, Nanog and Ets1 are recruited on the LTR in embryonic stem cells; in the epiblast the complementary expression of Nanog and Gata/Ets correlates with the Ens-1 gene expression pattern; and Ens-1 transcripts are also detected in the hypoblast, an extraembryonic tissue expressing Gata4 and Ets2, but not Nanog. gata 78-82 Nanog homeobox Gallus gallus 198-203 22867996-6 2012 Functional analysis of the HELIOS-BCL11B fusion protein revealed reduced transcriptional suppression activity compared to that of the WT-BCL11B due to the loss of the N-terminal friend of GATA-repression motif, which functions as a metastasis-associated protein 2 binding site. gata 188-192 IKAROS family zinc finger 2 Homo sapiens 27-33 22867996-6 2012 Functional analysis of the HELIOS-BCL11B fusion protein revealed reduced transcriptional suppression activity compared to that of the WT-BCL11B due to the loss of the N-terminal friend of GATA-repression motif, which functions as a metastasis-associated protein 2 binding site. gata 188-192 BAF chromatin remodeling complex subunit BCL11B Homo sapiens 34-40 22867996-6 2012 Functional analysis of the HELIOS-BCL11B fusion protein revealed reduced transcriptional suppression activity compared to that of the WT-BCL11B due to the loss of the N-terminal friend of GATA-repression motif, which functions as a metastasis-associated protein 2 binding site. gata 188-192 BAF chromatin remodeling complex subunit BCL11B Homo sapiens 137-143 22525679-4 2012 The quality of the carbon source modulates UGA4 expression through two parallel pathways, each one acting on different regulatory elements, the UAS(GATA) and the UAS(GABA). gata 148-152 Uga4p Saccharomyces cerevisiae S288C 43-47 22865859-5 2012 Reporter assays suggested that two GATA motifs just upstream of the transcription start site in the ST2 promoter are critical for transcriptional activity. gata 35-39 ST2 Homo sapiens 100-103 22865859-6 2012 These two GATA motifs possess the capacity to bind GATA1 and GATA2 in EMSA. gata 10-14 GATA binding protein 1 Homo sapiens 51-56 22865859-6 2012 These two GATA motifs possess the capacity to bind GATA1 and GATA2 in EMSA. gata 10-14 GATA binding protein 2 Homo sapiens 61-66 22422726-6 2012 Using luciferase reporter analysis in rat cardiomyocytes, it can be shown that MEF2, GATA, and E-box regulatory elements are essential for efficient expression of the Myh7b gene. gata 85-89 myosin heavy chain 7B Rattus norvegicus 167-172 22420414-7 2012 Consistent with their expression patterns during chick embryonic development, Gata4, Nanog and Ets1 are recruited on the LTR in embryonic stem cells; in the epiblast the complementary expression of Nanog and Gata/Ets correlates with the Ens-1 gene expression pattern; and Ens-1 transcripts are also detected in the hypoblast, an extraembryonic tissue expressing Gata4 and Ets2, but not Nanog. gata 78-82 ENS-1 Gallus gallus 237-242 22420414-7 2012 Consistent with their expression patterns during chick embryonic development, Gata4, Nanog and Ets1 are recruited on the LTR in embryonic stem cells; in the epiblast the complementary expression of Nanog and Gata/Ets correlates with the Ens-1 gene expression pattern; and Ens-1 transcripts are also detected in the hypoblast, an extraembryonic tissue expressing Gata4 and Ets2, but not Nanog. gata 78-82 ENS-1 Gallus gallus 272-277 22420414-7 2012 Consistent with their expression patterns during chick embryonic development, Gata4, Nanog and Ets1 are recruited on the LTR in embryonic stem cells; in the epiblast the complementary expression of Nanog and Gata/Ets correlates with the Ens-1 gene expression pattern; and Ens-1 transcripts are also detected in the hypoblast, an extraembryonic tissue expressing Gata4 and Ets2, but not Nanog. gata 78-82 GATA binding protein 4 Gallus gallus 362-367 22420414-7 2012 Consistent with their expression patterns during chick embryonic development, Gata4, Nanog and Ets1 are recruited on the LTR in embryonic stem cells; in the epiblast the complementary expression of Nanog and Gata/Ets correlates with the Ens-1 gene expression pattern; and Ens-1 transcripts are also detected in the hypoblast, an extraembryonic tissue expressing Gata4 and Ets2, but not Nanog. gata 78-82 ETS proto-oncogene 2, transcription factor Gallus gallus 372-376 22420414-7 2012 Consistent with their expression patterns during chick embryonic development, Gata4, Nanog and Ets1 are recruited on the LTR in embryonic stem cells; in the epiblast the complementary expression of Nanog and Gata/Ets correlates with the Ens-1 gene expression pattern; and Ens-1 transcripts are also detected in the hypoblast, an extraembryonic tissue expressing Gata4 and Ets2, but not Nanog. gata 78-82 Nanog homeobox Gallus gallus 198-203 22420414-10 2012 By providing pluripotent cells with intact binding sites for Gata, Nanog, or both, Ens-1 LTR may promote distinct transcriptional networks in embryonic stem cells subpopulations and prime the separation between embryonic and extraembryonic fates. gata 61-65 ENS-1 Gallus gallus 83-88 22071109-7 2011 The enhancer is activated by Bmp, Wnt and Fgf, and it contains Gata-, Cdx-, Tcf/Lef-, ER71/Etv2- and Fox-binding sites, some of which are bound specifically by each of these transcription factors. gata 63-67 ets variant 2 Mus musculus 91-95 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 101-105 Egg-laying defective protein 27 Caenorhabditis elegans 0-6 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 101-105 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase Caenorhabditis elegans 34-39 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 101-105 GATA-type domain-containing protein Caenorhabditis elegans 95-100 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 101-105 Egg-laying defective protein 27 Caenorhabditis elegans 123-129 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 166-170 Egg-laying defective protein 27 Caenorhabditis elegans 0-6 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 166-170 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase Caenorhabditis elegans 34-39 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 166-170 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 79-85 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 166-170 GATA-type domain-containing protein Caenorhabditis elegans 95-100 23271974-5 2012 egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. gata 166-170 Egg-laying defective protein 27 Caenorhabditis elegans 123-129 23284307-3 2012 A GATA-1-FOG-1-Mi2 repressor complex was recently demonstrated to be recruited to the -566 GATA motif of the (A)gamma-globin gene. gata 2-6 zinc finger protein, multitype 1 Mus musculus 9-14 22235304-5 2012 Electrophoretic mobility shift assays and chromatin immunoprecipitation assays showed that GATA-1 directly bound to a GATA binding site in the ZNF268 promoter in vitro and in vivo. gata 91-95 zinc finger protein 268 Homo sapiens 143-149 22071109-8 2011 As these transcription factors are known to act under the control of the Bmp, Wnt and Fgf families, early Flk1 expression may be induced by cooperative interactions between Gata, Tcf/Lef, Cdx and ER71/Etv2 under the control of Bmp, Wnt and Fgf signaling. gata 173-177 kinase insert domain protein receptor Mus musculus 106-110 22194696-2 2011 Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown. gata 70-74 Transcription factor elt-2 Caenorhabditis elegans 61-66 22194696-2 2011 Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown. gata 70-74 Ferritin Caenorhabditis elegans 136-141 22194696-2 2011 Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown. gata 70-74 Ferritin Caenorhabditis elegans 146-151 21571865-5 2011 The GATA response was localized to a DNA regulatory region at position -101 in the rat LHbeta gene promoter which overlaps with a previously described cis-element for pituitary homeobox-1 (Pitx1) and is flanked by two SF-1/LRH-1 regulatory sites. gata 4-8 luteinizing hormone subunit beta Rattus norvegicus 87-93 21756893-6 2011 Although otx2 can activate both gata5 and gata6, and the prdm1a/krox homologue also activates some endoderm transcription factors, a feedback loop from Gata to otx2 and prdm1a is missing. gata 152-156 orthodenticle homeobox 2b Danio rerio 9-13 21756893-6 2011 Although otx2 can activate both gata5 and gata6, and the prdm1a/krox homologue also activates some endoderm transcription factors, a feedback loop from Gata to otx2 and prdm1a is missing. gata 152-156 GATA binding protein 5 Danio rerio 32-37 21756893-6 2011 Although otx2 can activate both gata5 and gata6, and the prdm1a/krox homologue also activates some endoderm transcription factors, a feedback loop from Gata to otx2 and prdm1a is missing. gata 152-156 GATA binding protein 6 Danio rerio 42-47 21756893-6 2011 Although otx2 can activate both gata5 and gata6, and the prdm1a/krox homologue also activates some endoderm transcription factors, a feedback loop from Gata to otx2 and prdm1a is missing. gata 152-156 PR domain containing 1a, with ZNF domain Danio rerio 57-63 21756893-6 2011 Although otx2 can activate both gata5 and gata6, and the prdm1a/krox homologue also activates some endoderm transcription factors, a feedback loop from Gata to otx2 and prdm1a is missing. gata 152-156 orthodenticle homeobox 2b Danio rerio 160-164 21756893-6 2011 Although otx2 can activate both gata5 and gata6, and the prdm1a/krox homologue also activates some endoderm transcription factors, a feedback loop from Gata to otx2 and prdm1a is missing. gata 152-156 PR domain containing 1a, with ZNF domain Danio rerio 169-175 21756893-7 2011 Furthermore, we found the positive regulation between gata5 and gata6 to further lock-on the mesendoderm specification by the Gata family. gata 126-130 GATA binding protein 5 Danio rerio 54-59 21756893-7 2011 Furthermore, we found the positive regulation between gata5 and gata6 to further lock-on the mesendoderm specification by the Gata family. gata 126-130 GATA binding protein 6 Danio rerio 64-69 21609320-5 2011 We identified a potential GATA-binding site within the human hepcidin promoter. gata 26-30 hepcidin antimicrobial peptide Homo sapiens 61-69 21609320-6 2011 Indeed, in hepatic HepG2 cells, luciferase experiments demonstrated that mutation of this GATA-binding site impaired the hepcidin promoter transcriptional activity in basal conditions. gata 90-94 hepcidin antimicrobial peptide Homo sapiens 121-129 21609320-10 2011 Finally, we found that mutation of the GATA-binding site impaired the interleukin-6 induction of hepcidin gene expression, but did not prevent the bone morphogenetic protein-6 response. gata 39-43 interleukin 6 Homo sapiens 70-83 21609320-10 2011 Finally, we found that mutation of the GATA-binding site impaired the interleukin-6 induction of hepcidin gene expression, but did not prevent the bone morphogenetic protein-6 response. gata 39-43 hepcidin antimicrobial peptide Homo sapiens 97-105 21571865-5 2011 The GATA response was localized to a DNA regulatory region at position -101 in the rat LHbeta gene promoter which overlaps with a previously described cis-element for pituitary homeobox-1 (Pitx1) and is flanked by two SF-1/LRH-1 regulatory sites. gata 4-8 paired-like homeodomain 1 Rattus norvegicus 167-187 21571865-5 2011 The GATA response was localized to a DNA regulatory region at position -101 in the rat LHbeta gene promoter which overlaps with a previously described cis-element for pituitary homeobox-1 (Pitx1) and is flanked by two SF-1/LRH-1 regulatory sites. gata 4-8 paired-like homeodomain 1 Rattus norvegicus 189-194 21571865-5 2011 The GATA response was localized to a DNA regulatory region at position -101 in the rat LHbeta gene promoter which overlaps with a previously described cis-element for pituitary homeobox-1 (Pitx1) and is flanked by two SF-1/LRH-1 regulatory sites. gata 4-8 splicing factor 1 Rattus norvegicus 218-222 21571865-5 2011 The GATA response was localized to a DNA regulatory region at position -101 in the rat LHbeta gene promoter which overlaps with a previously described cis-element for pituitary homeobox-1 (Pitx1) and is flanked by two SF-1/LRH-1 regulatory sites. gata 4-8 nuclear receptor subfamily 5, group A, member 2 Rattus norvegicus 223-228 21297973-5 2011 In particular, downregulation of Gata2 expression was mirrored by abundant GATA motifs in regions of reduced histone acetylation suggesting an important role in leukaemogenic transcriptional reprogramming. gata 75-79 GATA binding protein 2 Mus musculus 33-38 21279818-6 2011 Second, the expression of GATA1 target genes may be modified, at least in part, by GATA2 occupying the GATA-binding motifs. gata 26-30 GATA binding protein 2 Homo sapiens 83-88 21279818-7 2011 GATA2 is expressed earlier in erythropoiesis than GATA1, and prior GATA2 binding may afford GATA1 access to GATA motifs through epigenetic remodeling and thus facilitate target gene expression. gata 0-4 GATA binding protein 1 Homo sapiens 92-97 20484821-7 2010 Electrophoretic mobility shift, luciferase reporter, and chromatin immunoprecipitation assays showed that GATA3 binds specifically to a functional double-GATA motif within the GCMB promoter. gata 106-110 glial cells missing homolog 2 Mus musculus 176-180 21126317-8 2011 By RT-PCR, co-transfection studies and gel-shift assays, we show that Muc5b promoter activity is completely inhibited by TTF-1, whereas factors of the GATA family (GATA-4/GATA-5/GATA-6) are activators. gata 151-155 GATA binding protein 4 Mus musculus 164-170 20615953-5 2010 The ERV-9 LTR contains multiple CCAAT and GATA motifs and competitively recruits a high concentration of NF-Y and GATA-2 present in low abundance in adult erythroid cells to assemble an LTR/RNA polymerase II complex. gata 42-46 GATA binding protein 2 Homo sapiens 114-120 20740275-7 2010 The nitrogen source used for growth was suggested to be an important determinant of arsenite toxicity, in keeping with non-enzymatic roles of the URE2 gene product in GATA-type regulation. gata 167-171 glutathione peroxidase Saccharomyces cerevisiae S288C 146-150 20346173-4 2010 A typical LMO2 binding site consists of two elements, a GATA site and an E-box, with an interval of 9 approximately 12 bp. gata 56-60 LIM domain only 2 Homo sapiens 10-14 20384792-8 2010 The results of chromatin immunoprecipitation and electrophoretic mobility shift assays suggested that myogenin bound to GATA4 on the GATA elements and the C-terminal Zn-finger domain of GATA4 and the N-terminal region of myogenin were required for this synergistic activation of transcription. gata 120-124 myogenin Rattus norvegicus 102-110 19598245-8 2009 One Point mutation studies revealed that among six potential GATA binding sites located on the upstream region of the bIFNT gene, the one next to ETS2 site exhibited reduced luciferase activity. gata 61-65 ETS proto-oncogene 2, transcription factor Bos taurus 146-150 19829305-4 2010 We show that the Fli1 promoter is upregulated by Ets factors Ets1, Ets2, Fli1 and Elf1 either alone or in combination with GATA factors, but is inhibited by Tel. gata 123-127 Friend leukemia integration 1 Mus musculus 17-21 20402826-7 2010 Here we investigated the way in which Wnt/beta-catenin signalling functionally interacts with the GATA family of pro-cardiogenic transcription factors to regulate subsequent heart muscle differentiation. gata 98-102 catenin beta 1 L homeolog Xenopus laevis 42-54 20402826-14 2010 In conclusion, our findings show that the inhibition of heart development by Wnt/beta-catenin signalling during organogenesis is mediated by the loss of expression of GATA pro-cardiogenic transcription factors and reveal functional differences between those GATA factors in heart development. gata 167-171 catenin beta 1 L homeolog Xenopus laevis 81-93 20402826-14 2010 In conclusion, our findings show that the inhibition of heart development by Wnt/beta-catenin signalling during organogenesis is mediated by the loss of expression of GATA pro-cardiogenic transcription factors and reveal functional differences between those GATA factors in heart development. gata 258-262 catenin beta 1 L homeolog Xenopus laevis 81-93 20523068-3 2010 The double GATA (dblGATA) site is a high-affinity GATA-binding site in the GATA-1 promoter. gata 11-15 GATA binding protein 1 Mus musculus 75-81 20523068-3 2010 The double GATA (dblGATA) site is a high-affinity GATA-binding site in the GATA-1 promoter. gata 20-24 GATA binding protein 1 Mus musculus 75-81 19777209-4 2009 The possible role of Ure2p in acquiring sensitivity to oxidative stress by means of its regulatory role in the GATA signal transduction pathway was discussed. gata 111-115 glutathione peroxidase Saccharomyces cerevisiae S288C 21-26 19729519-9 2009 One of these enhancers contains functional GATA-binding sites, indicating the potential for a regulatory loop in which GATA factors control the expression of their partner protein FOG-1. gata 43-47 zinc finger protein, FOG family member 1 Danio rerio 180-185 19729519-9 2009 One of these enhancers contains functional GATA-binding sites, indicating the potential for a regulatory loop in which GATA factors control the expression of their partner protein FOG-1. gata 119-123 zinc finger protein, FOG family member 1 Danio rerio 180-185 19723625-3 2009 The Gata1 hematopoietic enhancer activity is strictly dependent on a GATA site located in the 5" region of the enhancer. gata 69-73 GATA binding protein 1 Mus musculus 4-9 19729597-5 2009 p300DeltaC/H3 significantly inhibited p300-induced activation of GATA- and myocyte enhancer factor 2-dependent promoters in cultured ventricular myocytes, and p300DeltaC/H3-TG mice showed cardiac dysfunction that was lethal by 20 weeks of age. gata 65-69 E1A binding protein p300 Mus musculus 0-4 19700764-5 2009 Chromatin immunoprecipitation (ChIP) analyses revealed that, in TS cells, GATA3 directly regulates Cdx2 transcription from a conserved GATA motif at the intron 1 region of the Cdx2 locus. gata 74-78 caudal type homeobox 2 Mus musculus 99-103 19306917-8 2009 By transient transfection into Cos-1 and TM4 cells, distal element I which contains GATA-binding sites and proximal element B containing the sex-determining region on Y chromosome gene (SRY) binding site were revealed to have an important role in transcriptional regulation of the wrasse DMRT1 when an enhancer sequence was provided. gata 84-88 doublesex and mab-3 related transcription factor 1 Mus musculus 288-293 19700764-5 2009 Chromatin immunoprecipitation (ChIP) analyses revealed that, in TS cells, GATA3 directly regulates Cdx2 transcription from a conserved GATA motif at the intron 1 region of the Cdx2 locus. gata 74-78 caudal type homeobox 2 Mus musculus 176-180 19497978-10 2009 Moreover, the activity of MED1 for SULT2A1 promoter was mediated by GATA-6 via the -190 GATA-binding site. gata 68-72 mediator complex subunit 1 Homo sapiens 26-30 19497978-10 2009 Moreover, the activity of MED1 for SULT2A1 promoter was mediated by GATA-6 via the -190 GATA-binding site. gata 68-72 sulfotransferase family 2A member 1 Homo sapiens 35-42 19357811-5 2009 Moreover, the promoter activity of 2487 eLuc containing two novel GATA sites was significantly elevated by co-transfection of a GATA-2 expression vector in proliferating Rcho-1 cells. gata 66-70 GATA binding protein 2 Rattus norvegicus 128-134 19104072-4 2009 In this article, we demonstrate that the extent to which Sit4 plays a role in NCR-sensitive transcription depends upon whether or not (i) Gzf3, a GATA repressor homologous to Dal80, is active in the genetic background assayed; (ii) Gat1 is able to activate transcription of the assayed gene in the absence of Gln3 in that genetic background; and (iii) the gene chosen as a reporter is able to be transcribed by Gln3 or Gat1 in the absence of the other GATA factor. gata 146-150 type 2A-related serine/threonine-protein phosphatase SIT4 Saccharomyces cerevisiae S288C 57-61 19104072-4 2009 In this article, we demonstrate that the extent to which Sit4 plays a role in NCR-sensitive transcription depends upon whether or not (i) Gzf3, a GATA repressor homologous to Dal80, is active in the genetic background assayed; (ii) Gat1 is able to activate transcription of the assayed gene in the absence of Gln3 in that genetic background; and (iii) the gene chosen as a reporter is able to be transcribed by Gln3 or Gat1 in the absence of the other GATA factor. gata 452-456 type 2A-related serine/threonine-protein phosphatase SIT4 Saccharomyces cerevisiae S288C 57-61 19355882-10 2009 Furthermore, preclinical respectively clinical trials have been performed with small orally active drugs that stimulate endogenous EPO production by activating the EPO promoter ("GATA-inhibitors": diazepane derivatives) or enhancer ("HIF-stabilizers": 2-oxoglutarate analogues). gata 179-183 erythropoietin Homo sapiens 131-134 18845640-6 2009 In placental trophoblast giant cells, cAMP is required for activation of the Star promoter, and the cis-elements mediating a maximal response were defined as cAMP response element 2 and GATA. gata 186-190 steroidogenic acute regulatory protein Rattus norvegicus 77-81 19095651-3 2009 Unlike other GATA-type zinc fingers that recognize the consensus sequence (A/C/T)GATA(A/G), the MED-1 zinc finger (MED1zf) binds the larger and atypical site GTATACT(T/C)(3). gata 13-17 mediator complex subunit 1 Homo sapiens 96-101 19355882-10 2009 Furthermore, preclinical respectively clinical trials have been performed with small orally active drugs that stimulate endogenous EPO production by activating the EPO promoter ("GATA-inhibitors": diazepane derivatives) or enhancer ("HIF-stabilizers": 2-oxoglutarate analogues). gata 179-183 erythropoietin Homo sapiens 164-167 18003741-0 2007 Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans. gata 6-10 REgulator of Fusion Caenorhabditis elegans 60-65 18951515-0 2008 Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice. gata 56-60 troponin T2, cardiac type Rattus norvegicus 117-135 18591257-7 2008 We show that GATA4 is required for cyclin D2, cyclin A2, and Cdk4 expression in the right ventricle and that the Cyclin D2 and Cdk4 promoters are bound and activated by GATA4 via multiple consensus GATA binding sites in each gene"s proximal promoter. gata 13-17 cyclin D2 Mus musculus 35-44 18591257-7 2008 We show that GATA4 is required for cyclin D2, cyclin A2, and Cdk4 expression in the right ventricle and that the Cyclin D2 and Cdk4 promoters are bound and activated by GATA4 via multiple consensus GATA binding sites in each gene"s proximal promoter. gata 13-17 cyclin A2 Mus musculus 46-55 18591257-7 2008 We show that GATA4 is required for cyclin D2, cyclin A2, and Cdk4 expression in the right ventricle and that the Cyclin D2 and Cdk4 promoters are bound and activated by GATA4 via multiple consensus GATA binding sites in each gene"s proximal promoter. gata 13-17 cyclin-dependent kinase 4 Mus musculus 61-65 18591257-7 2008 We show that GATA4 is required for cyclin D2, cyclin A2, and Cdk4 expression in the right ventricle and that the Cyclin D2 and Cdk4 promoters are bound and activated by GATA4 via multiple consensus GATA binding sites in each gene"s proximal promoter. gata 13-17 cyclin D2 Mus musculus 113-122 18591257-7 2008 We show that GATA4 is required for cyclin D2, cyclin A2, and Cdk4 expression in the right ventricle and that the Cyclin D2 and Cdk4 promoters are bound and activated by GATA4 via multiple consensus GATA binding sites in each gene"s proximal promoter. gata 13-17 GATA binding protein 4 Mus musculus 169-174 18522800-5 2008 In 3T3-L1 preadipocytes, the transcriptional factors GATA-2 and GATA-3 are known to down-regulate adipogenesis by direct binding to the C/EBPbeta protein and to the GATA-binding site on the PPARgamma2 promoter. gata 53-57 GATA binding protein 3 Mus musculus 64-70 18522800-5 2008 In 3T3-L1 preadipocytes, the transcriptional factors GATA-2 and GATA-3 are known to down-regulate adipogenesis by direct binding to the C/EBPbeta protein and to the GATA-binding site on the PPARgamma2 promoter. gata 53-57 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 136-145 18522800-5 2008 In 3T3-L1 preadipocytes, the transcriptional factors GATA-2 and GATA-3 are known to down-regulate adipogenesis by direct binding to the C/EBPbeta protein and to the GATA-binding site on the PPARgamma2 promoter. gata 53-57 peroxisome proliferator activated receptor gamma Mus musculus 190-200 18448117-7 2008 We showed that ELT-2 and PHA-4 proteins interact directly with the GATA and forkhead binding sequences, respectively, in gel mobility shift assays. gata 67-71 Transcription factor elt-2 Caenorhabditis elegans 15-20 18448117-7 2008 We showed that ELT-2 and PHA-4 proteins interact directly with the GATA and forkhead binding sequences, respectively, in gel mobility shift assays. gata 67-71 Defective pharyngeal development protein 4 Caenorhabditis elegans 25-30 18174356-5 2008 Insights into the functional roles played by GATA factors in adult organ systems have been hampered by the early embryonic lethality associated with the different Gata-null mice. gata 163-167 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 Mus musculus 45-49 18024960-6 2008 Site-directed mutagenesis of the GATA sequences, singly or in combination, reduces ftn-1 GFP reporter expression in the intestine. gata 33-37 Ferritin Caenorhabditis elegans 83-88 18024960-7 2008 In vitro DNA mobility shift assays show that the intestine-specific GATA protein ELT-2 binds to both GATA sequences. gata 68-72 Transcription factor elt-2 Caenorhabditis elegans 81-86 18671946-5 2008 Sm up-regulated the binding activity of GATA-6 to SM-MHC GATA site and activated the transfected SM-MHC promoter in proliferative VSMCs, while mutating the GATA-6 binding site abolished this activation. gata 40-44 myosin heavy chain 11 Homo sapiens 50-56 18625887-8 2008 ETO2-dependent direct repression of the Pf4 proximal promoter is mediated by GATA-binding sites and an E-Box motif. gata 77-81 CBFA2/RUNX1 partner transcriptional co-repressor 3 Homo sapiens 0-4 18625887-8 2008 ETO2-dependent direct repression of the Pf4 proximal promoter is mediated by GATA-binding sites and an E-Box motif. gata 77-81 platelet factor 4 Homo sapiens 40-43 18443038-4 2008 DNA-protein binding assays showed that the GATA motif of interest is capable of binding GATA-1 transcription factor in vitro and in vivo. gata 43-47 GATA binding protein 1 Homo sapiens 88-94 18347053-0 2008 Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site. gata 94-98 zinc finger protein, multitype 1 Mus musculus 101-106 17687519-13 2007 Chromatin immunoprecipitation revealed that GATA, AP-1 and NF-AT binding to IL-5 promoter was induced by LPS stimulation and that TQ inhibited GATA binding at the IL-5 promoter but did not affect AP-1 and NF-AT binding. gata 44-48 interleukin 5 Rattus norvegicus 76-80 17728253-11 2007 GATA enhancer sequences govern DKF-2 expression in intestine in vivo. gata 0-4 Serine/threonine-protein kinase dkf-2 Caenorhabditis elegans 31-36 17555758-2 2007 The cytokine IL-5 and a high-affinity double GATA-binding site within the GATA-1 promoter are critical for eosinophilopoiesis. gata 45-49 GATA binding protein 1 Mus musculus 74-80 17909262-6 2007 The Cyp19 promoter contains a cAMP response element-like sequence (CLS), two nuclear receptor elements half sites (NREs), a GATA binding site, a Yin Yang-1 (YY1) response element, and an activation protein 3 (AP3) binding site. gata 124-128 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 4-9 17909262-12 2007 Our results indicate that CLS is active only in follicles; whereas in the CL, binding to the GATA, NRE, and AP3 sites associates with changes in Cyp19 expression, suggesting that they control Cyp19 promoter activity in luteal cells. gata 93-97 cardiolipin synthase 1 Rattus norvegicus 26-29 17909262-12 2007 Our results indicate that CLS is active only in follicles; whereas in the CL, binding to the GATA, NRE, and AP3 sites associates with changes in Cyp19 expression, suggesting that they control Cyp19 promoter activity in luteal cells. gata 93-97 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 145-150 17875210-0 2007 GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells. gata 0-4 troponin I, cardiac 3 Mus musculus 36-54 17875210-1 2007 BACKGROUND: We reported previously that the cardiac troponin I (cTnI) promoter drives cardiac-specific expression of reporter genes in cardiac muscle cells and in transgenic mice, and that disruption of GATA elements inactivates the cTnI promoter in cultured cardiomyocytes. gata 203-207 troponin I, cardiac 3 Mus musculus 44-62 17875210-1 2007 BACKGROUND: We reported previously that the cardiac troponin I (cTnI) promoter drives cardiac-specific expression of reporter genes in cardiac muscle cells and in transgenic mice, and that disruption of GATA elements inactivates the cTnI promoter in cultured cardiomyocytes. gata 203-207 troponin I, cardiac 3 Mus musculus 64-68 17875210-1 2007 BACKGROUND: We reported previously that the cardiac troponin I (cTnI) promoter drives cardiac-specific expression of reporter genes in cardiac muscle cells and in transgenic mice, and that disruption of GATA elements inactivates the cTnI promoter in cultured cardiomyocytes. gata 203-207 troponin I, cardiac 3 Mus musculus 233-237 17875210-3 2007 RESULTS: Mutation or deletion of GATA elements induces a strong transcriptional activation of the cTnI promoter in regenerating skeletal muscle and in cultured skeletal muscle cells. gata 33-37 troponin I, cardiac 3 Mus musculus 98-102 17875210-4 2007 Electrophoretic mobility shift assays show that proteins present in nuclear extracts of C2C12 muscle cells bind the GATA motifs present in the cTnI promoter. gata 116-120 troponin I, cardiac 3 Mus musculus 143-147 17592720-3 2007 Isolation and functional analysis of the Fet3 promoter indicate that a GATA sequence element plays a role in iron-dependent expression of Fet3. gata 71-75 ferroxidase FET3 Saccharomyces cerevisiae S288C 41-45 17592720-3 2007 Isolation and functional analysis of the Fet3 promoter indicate that a GATA sequence element plays a role in iron-dependent expression of Fet3. gata 71-75 ferroxidase FET3 Saccharomyces cerevisiae S288C 138-142 17611647-10 2007 Two GATA-binding sites within intron 6 of human JMJD2B gene were conserved in mouse Jmjd2b gene. gata 4-8 lysine demethylase 4B Homo sapiens 48-54 17611647-10 2007 Two GATA-binding sites within intron 6 of human JMJD2B gene were conserved in mouse Jmjd2b gene. gata 4-8 lysine (K)-specific demethylase 4B Mus musculus 84-90 17587490-5 2007 Our results indicate that GATA binding sites at -90 and -81 in the rat BNP promoter are essential for the in vivo response to Ang II. gata 26-30 natriuretic peptide B Rattus norvegicus 71-74 17587490-5 2007 Our results indicate that GATA binding sites at -90 and -81 in the rat BNP promoter are essential for the in vivo response to Ang II. gata 26-30 angiotensinogen Rattus norvegicus 126-132 17605826-6 2007 Although the in vivo contribution is limited to cells of parietal endoderm lineage, Gata-induced extra-embryonic endoderm cells (gExEn) can be induced to differentiate into visceral endoderm-like cells in vitro by repression of Gata6. gata 84-88 GATA binding protein 6 Mus musculus 228-233 17290010-7 2007 -40 and -89 GATA binding sites in the IFABP promoter were required for the synergistic activation by Smad2, 3, and 4 and GATA4. gata 12-16 fatty acid binding protein 2 Homo sapiens 38-43 17290010-7 2007 -40 and -89 GATA binding sites in the IFABP promoter were required for the synergistic activation by Smad2, 3, and 4 and GATA4. gata 12-16 SMAD family member 2 Homo sapiens 101-109 17290010-7 2007 -40 and -89 GATA binding sites in the IFABP promoter were required for the synergistic activation by Smad2, 3, and 4 and GATA4. gata 12-16 GATA binding protein 4 Homo sapiens 121-126 17227882-5 2007 Mutation of the GATA binding site on the Cyp19 promoter and inhibition of GATA4 expression with specific small interfering RNA significantly reduced FSH-enhanced Cyp19 expression, whereas overexpression of GATA4 increased Cyp19 promoter activity. gata 16-20 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 41-46 17437998-5 2007 In addition, SSBP2 was found to augment transcription of the Protein 4.2 (P4.2) gene, a direct target of the E-box-GATA-binding complex, in an Ldb1-dependent manner and to increase endogenous Ldb1 and Lmo2 protein levels, E-box-GATA DNA-binding activity, and P4.2 and beta-globin expression in erythroid progenitors. gata 115-119 single stranded DNA binding protein 2 Homo sapiens 13-18 17437998-5 2007 In addition, SSBP2 was found to augment transcription of the Protein 4.2 (P4.2) gene, a direct target of the E-box-GATA-binding complex, in an Ldb1-dependent manner and to increase endogenous Ldb1 and Lmo2 protein levels, E-box-GATA DNA-binding activity, and P4.2 and beta-globin expression in erythroid progenitors. gata 115-119 erythrocyte membrane protein band 4.2 Homo sapiens 61-72 17437998-5 2007 In addition, SSBP2 was found to augment transcription of the Protein 4.2 (P4.2) gene, a direct target of the E-box-GATA-binding complex, in an Ldb1-dependent manner and to increase endogenous Ldb1 and Lmo2 protein levels, E-box-GATA DNA-binding activity, and P4.2 and beta-globin expression in erythroid progenitors. gata 115-119 erythrocyte membrane protein band 4.2 Homo sapiens 74-78 17437998-5 2007 In addition, SSBP2 was found to augment transcription of the Protein 4.2 (P4.2) gene, a direct target of the E-box-GATA-binding complex, in an Ldb1-dependent manner and to increase endogenous Ldb1 and Lmo2 protein levels, E-box-GATA DNA-binding activity, and P4.2 and beta-globin expression in erythroid progenitors. gata 228-232 single stranded DNA binding protein 2 Homo sapiens 13-18 17437998-5 2007 In addition, SSBP2 was found to augment transcription of the Protein 4.2 (P4.2) gene, a direct target of the E-box-GATA-binding complex, in an Ldb1-dependent manner and to increase endogenous Ldb1 and Lmo2 protein levels, E-box-GATA DNA-binding activity, and P4.2 and beta-globin expression in erythroid progenitors. gata 228-232 erythrocyte membrane protein band 4.2 Homo sapiens 61-72 17437998-5 2007 In addition, SSBP2 was found to augment transcription of the Protein 4.2 (P4.2) gene, a direct target of the E-box-GATA-binding complex, in an Ldb1-dependent manner and to increase endogenous Ldb1 and Lmo2 protein levels, E-box-GATA DNA-binding activity, and P4.2 and beta-globin expression in erythroid progenitors. gata 228-232 erythrocyte membrane protein band 4.2 Homo sapiens 74-78 17242194-7 2007 Transient transfections in human primary endothelial cells derived from umbilical vein (HUVECs) demonstrated that VE-cadherin promoter activity was dependent on the integrity of a specialized E-box associated with a GATA motif and was maximal with the coexpression of the different components of the TAL-1 complex. gata 216-220 cadherin 5 Homo sapiens 114-125 17227882-5 2007 Mutation of the GATA binding site on the Cyp19 promoter and inhibition of GATA4 expression with specific small interfering RNA significantly reduced FSH-enhanced Cyp19 expression, whereas overexpression of GATA4 increased Cyp19 promoter activity. gata 16-20 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 162-167 17227882-5 2007 Mutation of the GATA binding site on the Cyp19 promoter and inhibition of GATA4 expression with specific small interfering RNA significantly reduced FSH-enhanced Cyp19 expression, whereas overexpression of GATA4 increased Cyp19 promoter activity. gata 16-20 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 162-167 17312153-7 2007 This suppression of the TGF-beta1 promoter is mediated by the -1079 to -406 region, in which deletion of a GATA-binding motif at position -821 abrogates NF-AT-mediated activation of the TGF-beta1 promoter. gata 107-111 transforming growth factor, beta 1 Mus musculus 24-33 17312153-7 2007 This suppression of the TGF-beta1 promoter is mediated by the -1079 to -406 region, in which deletion of a GATA-binding motif at position -821 abrogates NF-AT-mediated activation of the TGF-beta1 promoter. gata 107-111 transforming growth factor, beta 1 Mus musculus 186-195 16924465-4 2006 Stimulation of cardiomyocytes with 100 nM AngII for 2 h activated the transcription factors AP-1 and GATA by 68.6+/-23.9 or 70.7+/-9.8%. gata 101-105 angiotensinogen Rattus norvegicus 42-47 16979593-3 2006 EMSA with DNA probes within the region reveals that binding of GATA motif bound proteins was decreased by LPS-treatment. gata 63-67 toll-like receptor 4 Mus musculus 106-109 17113066-8 2007 There are three zinc-finger GATA-type factors that are candidates to bind this extended GATA site in the differentiating C. elegans intestine: ELT-2, ELT-4 and ELT-7. gata 28-32 Transcription factor elt-2 Caenorhabditis elegans 143-148 17113066-8 2007 There are three zinc-finger GATA-type factors that are candidates to bind this extended GATA site in the differentiating C. elegans intestine: ELT-2, ELT-4 and ELT-7. gata 28-32 GATA-type domain-containing protein Caenorhabditis elegans 150-155 17113066-8 2007 There are three zinc-finger GATA-type factors that are candidates to bind this extended GATA site in the differentiating C. elegans intestine: ELT-2, ELT-4 and ELT-7. gata 28-32 Transcription factor elt-7 Caenorhabditis elegans 160-165 16924465-9 2006 In contrast to the early induction of GATA and AP-1, the transcription factor similar to mothers against decapentaplegic homolog (SMAD) was induced by AngII after 24 h. This stimulation was dependent on TGF-beta1 because it was blocked by antibodies specific for TGF-beta1. gata 38-42 angiotensinogen Rattus norvegicus 151-156 16924465-9 2006 In contrast to the early induction of GATA and AP-1, the transcription factor similar to mothers against decapentaplegic homolog (SMAD) was induced by AngII after 24 h. This stimulation was dependent on TGF-beta1 because it was blocked by antibodies specific for TGF-beta1. gata 38-42 transforming growth factor, beta 1 Rattus norvegicus 203-212 16407417-11 2006 The proximal smMLCK promoter also contains a consensus GATA-binding site that bound GATA-6. gata 55-59 myosin, light polypeptide kinase Mus musculus 13-19 16762033-3 2006 The HvMYBS3 protein expressed in bacteria binds to oligonucleotides containing a GATA core derived from the promoters of: (i) the developing endosperm gene Itr1 (5"-GATAAGATA-3") encoding trypsin inhibitor BTI-CMe, and (ii) the post-germinating aleurone gene Amy6.4 (5"-TATCCAC-3"/5"-GTGGATA-3") encoding a high-pI alpha-amylase. gata 81-85 ITR1 Hordeum vulgare 156-160 16949798-6 2006 Expression of a dominant-interfering form of GATA6, which inhibits transactivation of GATA targets, severely impairs the ability of dorsal leading edge mesendoderm to spread and translocate on fibronectin. gata 45-49 fibronectin 1 S homeolog Xenopus laevis 193-204 16407417-11 2006 The proximal smMLCK promoter also contains a consensus GATA-binding site that bound GATA-6. gata 55-59 GATA binding protein 6 Mus musculus 84-90 16452489-7 2006 Here we report that GATA-4, a transcription factor essential for heart development, binds to the Grp78 promoter in vivo and activates the ERSE, which does not contain a consensus GATA binding site. gata 20-24 heat shock protein 5 Mus musculus 97-102 16720723-7 2006 Transient transfection experiments in KK-1 cells demonstrated that dominant negative GATA-4 variants or mutations of GATA-binding sites in the inhibin-alpha promoter attenuated TGF-beta-induced gene activation. gata 85-89 transforming growth factor, beta 1 Mus musculus 177-185 16437149-0 2006 The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells. gata 4-8 GATA binding protein 1 Homo sapiens 75-80 16437149-4 2006 GATA1, not GATA2, binds to the GATA binding sites and transactivates the Hemgn promoter in a dose-dependent manner. gata 0-4 hemogen Homo sapiens 73-78 16325171-3 2006 We have previously shown that the binding site recognized by MED-1 is a noncanonical RAGTATAC site that is not expected from the resemblance of its single C4-type zinc finger to those of other known GATA factors, which recognize the consensus HGATAR. gata 199-203 GATA-type domain-containing protein Caenorhabditis elegans 61-66 16373364-2 2006 An important role for the proximal AP-1 and GATA sites in regulating IL-5 transcription is generally accepted but the significance of an adjacent Ets/NFAT site has remained unclear. gata 44-48 interleukin 5 Mus musculus 69-73 16373364-6 2006 Mutagenesis showed that the Ets/NFAT site is of critical importance along with the AP-1 and GATA sites in regulating IL-5 transcription stimulated by PMA/cAMP and MAP kinase activation. gata 92-96 interleukin 5 Mus musculus 117-121 16055713-0 2005 GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. gata 0-4 GATA binding protein 2 Mus musculus 76-81 16413408-6 2006 The ability of mouse GATA factors to transactivate the Nox1 promoter was demonstrated in Cos-7 cells and site-directed mutagenesis of the conserved GATA-binding site further demonstrates that the regulation of Nox1 transcription is mediated by the direct binding of a GATA factor to the Nox1 proximal promoter. gata 21-25 NADPH oxidase 1 Mus musculus 55-59 16413408-6 2006 The ability of mouse GATA factors to transactivate the Nox1 promoter was demonstrated in Cos-7 cells and site-directed mutagenesis of the conserved GATA-binding site further demonstrates that the regulation of Nox1 transcription is mediated by the direct binding of a GATA factor to the Nox1 proximal promoter. gata 21-25 NADPH oxidase 1 Homo sapiens 210-214 16413408-6 2006 The ability of mouse GATA factors to transactivate the Nox1 promoter was demonstrated in Cos-7 cells and site-directed mutagenesis of the conserved GATA-binding site further demonstrates that the regulation of Nox1 transcription is mediated by the direct binding of a GATA factor to the Nox1 proximal promoter. gata 21-25 NADPH oxidase 1 Homo sapiens 210-214 16286657-4 2005 We found that conditionally active GATA-1 (ER-GATA-1) and GATA-2 occupy only a small subset of the conserved GATA motifs within the murine beta-globin locus. gata 35-39 GATA binding protein 1 Mus musculus 43-52 16286657-5 2005 Kinetic analyses in GATA-1-null cells indicated that ER-GATA-1 preferentially occupied GATA motifs at the locus control region (LCR), in which chromatin accessibility is largely GATA-1-independent. gata 20-24 GATA binding protein 1 Mus musculus 53-62 16286657-5 2005 Kinetic analyses in GATA-1-null cells indicated that ER-GATA-1 preferentially occupied GATA motifs at the locus control region (LCR), in which chromatin accessibility is largely GATA-1-independent. gata 20-24 GATA binding protein 1 Mus musculus 56-62 16274253-11 2005 Deletion of either the 5" E box or the 3" E box and the GATA element in the VEGFR-2 promoter completely abolished the inhibition of VEGFR-2 promoter activity elicited by VEGFR-1 siRNA. gata 56-60 kinase insert domain receptor Bos taurus 76-83 16274253-11 2005 Deletion of either the 5" E box or the 3" E box and the GATA element in the VEGFR-2 promoter completely abolished the inhibition of VEGFR-2 promoter activity elicited by VEGFR-1 siRNA. gata 56-60 kinase insert domain receptor Bos taurus 132-139 16274253-11 2005 Deletion of either the 5" E box or the 3" E box and the GATA element in the VEGFR-2 promoter completely abolished the inhibition of VEGFR-2 promoter activity elicited by VEGFR-1 siRNA. gata 56-60 fms related receptor tyrosine kinase 1 Bos taurus 170-177 15980430-9 2005 In addition, PKN increased the activities of serum-response factor (SRF), GATA, and MEF2-dependent enhancer-reporters. gata 74-78 protein kinase N1 Homo sapiens 13-16 16012775-10 2005 GATA and E47 binding sites were conserved among human FGF23, rat Fgf23, and mouse Fgf23 promoters. gata 0-4 fibroblast growth factor 23 Homo sapiens 54-59 16012775-10 2005 GATA and E47 binding sites were conserved among human FGF23, rat Fgf23, and mouse Fgf23 promoters. gata 0-4 fibroblast growth factor 23 Rattus norvegicus 65-70 16012775-10 2005 GATA and E47 binding sites were conserved among human FGF23, rat Fgf23, and mouse Fgf23 promoters. gata 0-4 fibroblast growth factor 23 Mus musculus 82-87 15869801-2 2005 In sheep, we recently discovered a putative GATA-binding site (WGATAR) in the second intron of the Th1-cytokine gene interleukin 2 (IL2), showing a single nucleotide polymorphism (G/C). gata 44-48 interleukin-2 Ovis aries 117-130 15869801-2 2005 In sheep, we recently discovered a putative GATA-binding site (WGATAR) in the second intron of the Th1-cytokine gene interleukin 2 (IL2), showing a single nucleotide polymorphism (G/C). gata 44-48 interleukin-2 Ovis aries 132-135 16055713-5 2005 Detailed transgenic mouse reporter expression analyses demonstrate that five GATA motifs within the 3.1-kbp Gata2 early hematopoietic regulatory domain (G2-EHRD) were essential for GFP expression within the dorsal aortic wall, where hemangioblasts, the earliest precursors possessing both hematopoietic and vascular developmental potential, are thought to reside. gata 77-81 GATA binding protein 2 Mus musculus 108-113 12888492-4 2003 We found that str1+ is subject to negative transcriptional regulation, which is exerted through binding of Fep1 to a single GATA element in the str1+ promoter. gata 124-128 cystathionine gamma-lyase CYS3 Saccharomyces cerevisiae S288C 14-18 15843409-6 2005 The Mef2c AHF enhancer relies on Isl1- and Gata-binding sites. gata 43-47 myocyte enhancer factor 2C Mus musculus 4-9 15780659-2 2005 One such system, the target of rapamycin (Tor) proteins, senses nutrients and uses the GATA activators Gln3p and Nil1p to regulate translation in response to low-quality carbon and nitrogen. gata 87-91 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 103-108 15780659-2 2005 One such system, the target of rapamycin (Tor) proteins, senses nutrients and uses the GATA activators Gln3p and Nil1p to regulate translation in response to low-quality carbon and nitrogen. gata 87-91 Gat1p Saccharomyces cerevisiae S288C 113-118 15737937-4 2005 We report that MED-1 binds invariant noncanonical sites in the end genes, revealing that the MEDs are atypical members of the GATA factor family that do not recognize GATA sequences. gata 126-130 GATA-type domain-containing protein Caenorhabditis elegans 15-20 15539431-6 2005 Mutation of the GATA binding site on G5 abrogated the transcriptional activation mediated by Gata-4 and reduced basal glucagon gene promoter activity in glucagon-producing cells by 55%. gata 16-20 LOW QUALITY PROTEIN: transcription factor GATA-4 Cricetulus griseus 93-99 15670213-2 2005 GATA-binding motifs have been found in the regulatory regions of various erythroid-specific genes, suggesting that GATA-1 contributes to gene regulation during the entire process of erythropoiesis. gata 0-4 GATA binding protein 1 Mus musculus 115-121 15541382-3 2004 Having found putative GATA binding sites in the murine Muc2 promoter and that GATA-4 is expressed in Muc2-expressing goblet cells of the mouse small intestine, we undertook to study its regulation by this transcription factor. gata 22-26 mucin 2 Mus musculus 55-59 15501582-8 2004 In all postnatal ovaries, the expression of P450scc localized with tissue expressing GATA-4 and/or GATA-6, but GATA expression also occurred in P450scc negative cells. gata 85-89 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 44-51 15896659-2 2005 We identified and characterized a new C/T substitution at position -689 (-689C>T) in the P2 promoter of PPARgamma in a putative GATA binding site. gata 131-135 peroxisome proliferator activated receptor gamma Homo sapiens 107-116 15862566-10 2005 The zebrafish ff1a dual promoter contains several GATA binding sites and E-boxes, a site for DR4, XFD2, MyoD, Snail, HNF3, S8, and an HMG-box recognition site for Sox9. gata 50-54 nuclear receptor subfamily 5, group A, member 2 Danio rerio 14-18 15659482-8 2005 Together with the timing of their expression and the effects of GATA MOs in vivo, these observations identify GATA6 as the predominant GATA factor in the maintenance of endodermal gene expression by TGFbeta signaling in gastrulating embryos. gata 64-68 GATA binding protein 6 L homeolog Xenopus laevis 110-115 15572669-3 2004 For example, prohypertrophic transcription factors belonging to the nuclear factor of activated T cells (NFAT) and GATA families are subject to CRM1-dependent nuclear export but are rapidly relocalized to the nucleus in response to cues for hypertrophic growth. gata 115-119 exportin 1 Homo sapiens 144-148 15256532-4 2004 A GATA-4 expression plasmid cotransfected with a murine LHR promoter-driven luciferase reporter plasmid, containing a consensus GATA-binding site, induced a dose-dependent significant transactivation of the LHR promoter in nonsteroidogenic human embryonic kidney 293, steroidogenic murine mLTC-1 Leydig cells and in murine adrenal Y-1 cells. gata 2-6 luteinizing hormone/choriogonadotropin receptor Mus musculus 56-59 15256532-4 2004 A GATA-4 expression plasmid cotransfected with a murine LHR promoter-driven luciferase reporter plasmid, containing a consensus GATA-binding site, induced a dose-dependent significant transactivation of the LHR promoter in nonsteroidogenic human embryonic kidney 293, steroidogenic murine mLTC-1 Leydig cells and in murine adrenal Y-1 cells. gata 2-6 luteinizing hormone/choriogonadotropin receptor Mus musculus 207-210 15302915-7 2004 Transfections with wild-type and mutant promoter constructs in cardiac HL-1 cells indicated that one GATA box is absolutely required for high alphaT-catenin promoter activity in these cells. gata 101-105 catenin (cadherin associated protein), alpha 3 Mus musculus 142-156 15123623-7 2004 An estrogen receptor fusion to GATA-1 (ER-GATA-1) and endogenous GATA-1 both occupied a region of Tac-2 intron-7, which contains two conserved GATA motifs. gata 31-35 GATA binding protein 1 Mus musculus 39-48 15123623-7 2004 An estrogen receptor fusion to GATA-1 (ER-GATA-1) and endogenous GATA-1 both occupied a region of Tac-2 intron-7, which contains two conserved GATA motifs. gata 31-35 GATA binding protein 1 Mus musculus 42-48 15123623-7 2004 An estrogen receptor fusion to GATA-1 (ER-GATA-1) and endogenous GATA-1 both occupied a region of Tac-2 intron-7, which contains two conserved GATA motifs. gata 31-35 tachykinin 2 Mus musculus 98-103 15140029-10 2004 In conclusion, we have identified a novel polymorphic GATA site that may affect transciptional activity of the human IL-12Rbeta2 gene under GATA3-mediated, Th2-polarizing conditions. gata 54-58 GATA binding protein 3 Homo sapiens 140-145 14701820-5 2004 HS1 participates in the transcriptional autoregulation of GATA-1 through an essential GATA-binding site that is footprinted in vivo. gata 58-62 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 0-3 14555463-6 2004 In response to TNF-alpha treatment for 4 h, nuclear protein binding to (32)P oligonucleotides was characterized as: 1) a significant increase in binding to (-370)CACCC, 2) a significant decrease in binding to (-231)GATA, and 3) no change in (-186)CACCC binding. gata 215-219 tumor necrosis factor Homo sapiens 15-24 14614148-0 2003 Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. gata 41-45 zinc finger protein, multitype 1 Mus musculus 55-71 14613857-9 2003 Furthermore, the coregulator of GATA, FOG2, markedly suppresses the GATA-induced increase in myocytes, but enhances it in PC12 cells. gata 32-36 zinc finger protein, multitype 2 Rattus norvegicus 38-42 14613857-9 2003 Furthermore, the coregulator of GATA, FOG2, markedly suppresses the GATA-induced increase in myocytes, but enhances it in PC12 cells. gata 68-72 zinc finger protein, multitype 2 Rattus norvegicus 38-42 14613857-10 2003 The use of GATA mutants that are incapable of forming complexes with FOG2 indicates that the formation of GATA-FOG complexes is required for the FOG2-induced suppression in myocytes, but not for the FOG2-mediated enhancement in PC12 cells. gata 106-110 zinc finger protein, multitype 2 Rattus norvegicus 69-73 14613857-10 2003 The use of GATA mutants that are incapable of forming complexes with FOG2 indicates that the formation of GATA-FOG complexes is required for the FOG2-induced suppression in myocytes, but not for the FOG2-mediated enhancement in PC12 cells. gata 106-110 zinc finger protein, multitype 2 Rattus norvegicus 145-149 14613857-10 2003 The use of GATA mutants that are incapable of forming complexes with FOG2 indicates that the formation of GATA-FOG complexes is required for the FOG2-induced suppression in myocytes, but not for the FOG2-mediated enhancement in PC12 cells. gata 106-110 zinc finger protein, multitype 2 Rattus norvegicus 145-149 14613857-12 2003 The lack of a GATA-binding consensus sequence in the Kv4.2 minimum promoter suggests that these transcription factors indirectly influence the channel gene transcription. gata 14-18 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 53-58 12888492-4 2003 We found that str1+ is subject to negative transcriptional regulation, which is exerted through binding of Fep1 to a single GATA element in the str1+ promoter. gata 124-128 cystathionine gamma-lyase CYS3 Saccharomyces cerevisiae S288C 144-148 12706632-8 2003 A hypothesis involving protein-protein interactions between C/EBP (pX2/BCFII) and GATA during choriogenesis is presented to explain the temporal specificity of chorion genes. gata 82-86 chorion specific C/EBP Bombyx mori 60-65 12650603-11 2003 It also appears to behave like a GATA-element transcription factor, since transfection of a GATA-element reporter into MTA1-expressing cells resulted in 10-20-fold increase in reporter expression over poorly MTA1-expressing cells. gata 33-37 metastasis associated 1 Homo sapiens 119-123 12504119-7 2003 Based on these results, we propose that light controls the expression of GAPA and GAPB genes in part by regulating the binding of the same transcription factor at their GATA motifs. gata 169-173 glyceraldehyde 3-phosphate dehydrogenase A subunit Arabidopsis thaliana 73-77 12724402-7 2003 Quantitative electrophoretic mobility shift assays using oligonucleotides derived from the GPIX promoter containing Ets and GATA binding motifs reveal that Fli-1 and GATA-1 exhibit cooperative DNA binding in which the binding of GATA-1 to DNA is increased approximately 26-fold in the presence of Fli-1 (from 4.2 to 0.16 nM), providing a mechanism for the observed transcriptional synergy. gata 124-128 glycoprotein IX platelet Homo sapiens 91-95 12724402-7 2003 Quantitative electrophoretic mobility shift assays using oligonucleotides derived from the GPIX promoter containing Ets and GATA binding motifs reveal that Fli-1 and GATA-1 exhibit cooperative DNA binding in which the binding of GATA-1 to DNA is increased approximately 26-fold in the presence of Fli-1 (from 4.2 to 0.16 nM), providing a mechanism for the observed transcriptional synergy. gata 124-128 Fli-1 proto-oncogene, ETS transcription factor Homo sapiens 156-161 12724402-7 2003 Quantitative electrophoretic mobility shift assays using oligonucleotides derived from the GPIX promoter containing Ets and GATA binding motifs reveal that Fli-1 and GATA-1 exhibit cooperative DNA binding in which the binding of GATA-1 to DNA is increased approximately 26-fold in the presence of Fli-1 (from 4.2 to 0.16 nM), providing a mechanism for the observed transcriptional synergy. gata 124-128 GATA binding protein 1 Homo sapiens 166-172 12724402-7 2003 Quantitative electrophoretic mobility shift assays using oligonucleotides derived from the GPIX promoter containing Ets and GATA binding motifs reveal that Fli-1 and GATA-1 exhibit cooperative DNA binding in which the binding of GATA-1 to DNA is increased approximately 26-fold in the presence of Fli-1 (from 4.2 to 0.16 nM), providing a mechanism for the observed transcriptional synergy. gata 124-128 GATA binding protein 1 Homo sapiens 229-235 12480945-4 2003 The RXR alpha-mediated repression mapped to the proximal 147 bp of the rat ANF promoter, a region lacking a consensus retinoid response element but containing several known cardiogenic cis elements including a well characterized GATA response element. gata 229-233 retinoid X receptor alpha Rattus norvegicus 4-13 12480945-6 2003 Liganded RXR alpha repressed the activity of a heterologous promoter-reporter construct containing GATA-response element recognition sites in cardiac myocytes but not in several other cell types, suggesting that additional cardiac-enriched factors participate in the repression complex. gata 99-103 retinoid X receptor alpha Rattus norvegicus 9-18 12650603-11 2003 It also appears to behave like a GATA-element transcription factor, since transfection of a GATA-element reporter into MTA1-expressing cells resulted in 10-20-fold increase in reporter expression over poorly MTA1-expressing cells. gata 33-37 metastasis associated 1 Homo sapiens 208-212 11788768-3 2002 The presence of GATA-like motifs in the upstream region of the Acl1.4 gene (encoding for ACP4) and the similarity in light-mediated induction to ferredoxin-A mRNA suggests a direct role of light in Acl1.4 gene activation. gata 16-20 acyl carrier protein 4 Arabidopsis thaliana 89-93 12532156-5 2003 RESULTS: Three common MC3R variants were found: a 17C>A variant, changing Thr6-->Lys in 16%, a 241G>A variant changing Val81-->Ile in 15%, and a -239A>G substitution in the GATA binding site in 21% of the subjects. gata 188-192 melanocortin 3 receptor Homo sapiens 22-26 12202480-7 2002 In vitro mutational analyses of the MBP-P2 promoter showed that both the GATA-1/PU.1 synergy, and repressor activity of C/EBPepsilon(27) are mediated via protein-protein interactions through the C/EBP and/or GATA-binding sites but not the PU.1 sites. gata 73-77 myelin basic protein Homo sapiens 36-39 12391281-5 2002 Electrophoretic mobility shift assays (EMSAs) indicate that the putative CRE and GATA sites indeed bind cAMP response element modulator 1/c-Jun and the GATA6 protein, respectively. gata 81-85 GATA binding protein 6 Rattus norvegicus 152-157 12200364-9 2002 Compared with wild-type GATA-1, Arg216Gln GATA-1 shows comparable affinity to single GATA sites but decreased affinity to palindromic sites. gata 24-28 GATA binding protein 1 Homo sapiens 42-48 11978798-9 2002 Transfection with a dominant negative AP-1 construct or mutation of the AP-1, GATA, or C/EBP sites in the -272-bp IL-8 promoter construct blocked induction by nickel. gata 78-82 C-X-C motif chemokine ligand 8 Homo sapiens 114-118 12054852-0 2002 Transcriptional activation of the BNP gene by lipopolysaccharide is mediated through GATA elements in neonatal rat cardiac myocytes. gata 85-89 natriuretic peptide B Rattus norvegicus 34-37 12054852-10 2002 Mutation of the GATA sequence located at -95 and -84 abolished such an induction of BNP promoter activity. gata 16-20 natriuretic peptide B Rattus norvegicus 84-87 12054852-12 2002 These results indicate that LPS induces the BNP gene expression through a pathway involving CD14, Rac1, p38 MAPK and GATA elements. gata 117-121 natriuretic peptide B Rattus norvegicus 44-47 12702322-8 2002 Furthermore, deletion analyses and mutagenesis have shown that the palindromic sequence is important for full repression of GCV2 in complex glucose-containing medium and functions in a manner that is different from control mediated by the GATA element. gata 239-243 glycine decarboxylase subunit P Saccharomyces cerevisiae S288C 124-128 18763064-7 2002 There is a cis-activating GATA motif in ENH of DLA-EIAV and EIAV L. Two N-linked glycosylation sites disappeared in DLA-EIAV Gp90 in comparison with that of EIAV L. A bHLH transcription factor binding consensus sequence was found in LTR of DLA-EIAV but not in EIAV L. Furthermore, there is a mutation in the stem of DLA-EIAV TAR resulting in formation of a uridine tuber. gata 26-30 galectin 3 binding protein Homo sapiens 125-129 11862325-3 2002 Rat B-type natriuretic peptide (BNP) gene promoter contains a region of two adjacent GATA binding sites (between -68 and -97) with high affinity for GATA-4. gata 85-89 natriuretic peptide B Rattus norvegicus 4-30 11862325-3 2002 Rat B-type natriuretic peptide (BNP) gene promoter contains a region of two adjacent GATA binding sites (between -68 and -97) with high affinity for GATA-4. gata 85-89 natriuretic peptide B Rattus norvegicus 32-35 11862325-3 2002 Rat B-type natriuretic peptide (BNP) gene promoter contains a region of two adjacent GATA binding sites (between -68 and -97) with high affinity for GATA-4. gata 85-89 GATA binding protein 4 Rattus norvegicus 149-155 11862325-5 2002 GATA decoy oligodeoxynucleotide treatment of cardiomyocytes blocked GATA-4 DNA binding activity in electrophoretic mobility shift analysis and decreased baseline expression of cardiac natriuretic peptides and GATA-dependent promoter activity. gata 0-4 GATA binding protein 4 Rattus norvegicus 68-74 11862325-7 2002 Mutation of GATA binding sites at -80 and -91 rat BNP promoter downregulated baseline but did not affect endothelin-1 or angiotensin II induced promoter activity. gata 12-16 natriuretic peptide B Rattus norvegicus 50-53 12446778-3 2002 TRPS1, the only other vertebrate protein with the GATA motif, is a large, multitype zinc finger protein that harbors a single DNA-binding GATA domain and represses transcription. gata 50-54 transcriptional repressor GATA binding 1 Mus musculus 0-5 12446778-3 2002 TRPS1, the only other vertebrate protein with the GATA motif, is a large, multitype zinc finger protein that harbors a single DNA-binding GATA domain and represses transcription. gata 138-142 transcriptional repressor GATA binding 1 Mus musculus 0-5 12446778-4 2002 Monoallelic TRPS1 mutations cause two dominantly inherited human developmental disorders of the hair, face, and digits, tricho-rhino-phalangeal syndrome (TRPS) types I (MIM 190350) and III (MIM 190351); missense GATA domain mutations account for the more severe type III form. gata 212-216 transcriptional repressor GATA binding 1 Homo sapiens 12-17 12150943-5 2002 A conserved GATA site in the intergenic region was shown by site-directed mutagenesis to act as a repressor for the ABCG5 promoter. gata 12-16 ATP binding cassette subfamily G member 5 Homo sapiens 116-121 12045237-0 2002 Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. gata 37-41 GATA binding protein 1 Mus musculus 62-68 12045237-3 2002 Here we demonstrate that deletion of a high-affinity GATA-binding site in the GATA-1 promoter, an element presumed to mediate positive autoregulation of GATA-1 expression, leads to selective loss of the eosinophil lineage. gata 53-57 GATA binding protein 1 Mus musculus 78-84 12045237-3 2002 Here we demonstrate that deletion of a high-affinity GATA-binding site in the GATA-1 promoter, an element presumed to mediate positive autoregulation of GATA-1 expression, leads to selective loss of the eosinophil lineage. gata 53-57 GATA binding protein 1 Mus musculus 153-159 11827958-6 2002 Overexpression of p38 kinase pathway, but not extracellular signal-regulated kinase or c-Jun N-terminal protein kinase, activated GATA-4 binding to B-type natriuretic peptide gene and induced rat B-type natriuretic peptide promoter activity via proximal GATA binding sites. gata 130-134 mitogen activated protein kinase 14 Rattus norvegicus 18-21 11827958-7 2002 In conclusion, these findings demonstrate that activation of p38 kinase is necessary for hypertrophic agonist-induced GATA-4 binding to B-type natriuretic peptide gene and sufficient for GATA-dependent B-type natriuretic peptide gene expression. gata 118-122 mitogen activated protein kinase 14 Rattus norvegicus 61-64 11842118-9 2002 The substitution in PS4A of a GATA-binding sequence similar to PS13, which only requires a single zinc finger domain, bound GATA-4 efficiently but did not activate the Fgf-3 promoter. gata 30-34 GATA binding protein 4 Homo sapiens 124-130 12432220-4 2002 Closer examination revealed a cross-regulatory mechanism by which GATA-1 can control the expression of GATA-2 and vice versa, possibly via essential GATA binding sites in their cis-acting elements. gata 66-70 GATA binding protein 2 Homo sapiens 103-109 11408486-2 2001 When nitrogen is limiting, Gln3p and Gat1p are concentrated in the nucleus where they bind GATA sequences upstream of nitrogen catabolite repression (NCR)-sensitive genes and activate their transcription. gata 91-95 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 27-32 11606434-7 2001 The importance of these GATA elements to BNP promoter activation was further confirmed by the corresponding 38-bp oligonucleotide conferring hemodynamic stress responsiveness to a minimal BNP promoter. gata 24-28 natriuretic peptide B Rattus norvegicus 41-44 11606434-7 2001 The importance of these GATA elements to BNP promoter activation was further confirmed by the corresponding 38-bp oligonucleotide conferring hemodynamic stress responsiveness to a minimal BNP promoter. gata 24-28 natriuretic peptide B Rattus norvegicus 188-191 11606434-9 2001 In conclusion, GATA elements are necessary and sufficient to confer transcriptional activation of BNP gene in response to hemodynamic stress. gata 15-19 natriuretic peptide B Rattus norvegicus 98-101 11356843-2 2001 When cells are cultured with a good nitrogen source (glutamine, ammonia), Gln3p and Gat1p are restricted to the cytoplasm, whereas with a poor nitrogen source (proline), they localize to the nucleus, bind to the GATA sequences of NCR-sensitive gene promoters, and activate transcription. gata 212-216 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 74-79 11356843-2 2001 When cells are cultured with a good nitrogen source (glutamine, ammonia), Gln3p and Gat1p are restricted to the cytoplasm, whereas with a poor nitrogen source (proline), they localize to the nucleus, bind to the GATA sequences of NCR-sensitive gene promoters, and activate transcription. gata 212-216 Gat1p Saccharomyces cerevisiae S288C 84-89 11408486-2 2001 When nitrogen is limiting, Gln3p and Gat1p are concentrated in the nucleus where they bind GATA sequences upstream of nitrogen catabolite repression (NCR)-sensitive genes and activate their transcription. gata 91-95 Gat1p Saccharomyces cerevisiae S288C 37-42 11259267-7 2001 Dax-1-mediated repression of GATA-4/SF-1 synergism did not involve direct repression of GATA-dependent transactivation, but rather, it occurred through a direct protein-protein interaction with DNA-bound SF-1. gata 29-33 nuclear receptor subfamily 0 group B member 1 Homo sapiens 0-5 11493575-3 2001 To analyze the role played by GATAb in the regulation of the Fbp1 EcRU activity, we have replaced the GATA-binding sites GBS1, GBS2 and GBS3 in the Fbp1 EcRU with UAS sites for the yeast GAL4 activator and tested the activity of the mutagenized Fbp1 EcRUs in transgenic lines, either in the presence or absence of ubiquitously expressed GAL4. gata 30-34 fructose 1,6-bisphosphate 1-phosphatase Saccharomyces cerevisiae S288C 61-65 11493553-1 2001 Expression of gata1 is regulated through multiple cis-acting GATA motifs. gata 61-65 GATA binding protein 1a Danio rerio 14-19 11493553-5 2001 GFP reporter analyses revealed that this intron and a distal double GATA motif in the regulatory region are important for the regulation of zebrafish gata1 gene expression. gata 68-72 GATA binding protein 1a Danio rerio 150-155 11259267-7 2001 Dax-1-mediated repression of GATA-4/SF-1 synergism did not involve direct repression of GATA-dependent transactivation, but rather, it occurred through a direct protein-protein interaction with DNA-bound SF-1. gata 29-33 splicing factor 1 Homo sapiens 36-40 11259267-7 2001 Dax-1-mediated repression of GATA-4/SF-1 synergism did not involve direct repression of GATA-dependent transactivation, but rather, it occurred through a direct protein-protein interaction with DNA-bound SF-1. gata 29-33 splicing factor 1 Homo sapiens 204-208 11259267-9 2001 Because we have shown that other GATA family members also have the ability to synergize with SF-1, Dax-1 repression of GATA/SF-1 synergism may represent an important mechanism for fine-tuning the regulation of SF-1-dependent genes in multiple target tissues. gata 33-37 splicing factor 1 Homo sapiens 93-97 11259267-9 2001 Because we have shown that other GATA family members also have the ability to synergize with SF-1, Dax-1 repression of GATA/SF-1 synergism may represent an important mechanism for fine-tuning the regulation of SF-1-dependent genes in multiple target tissues. gata 33-37 nuclear receptor subfamily 0 group B member 1 Homo sapiens 99-104 11259267-9 2001 Because we have shown that other GATA family members also have the ability to synergize with SF-1, Dax-1 repression of GATA/SF-1 synergism may represent an important mechanism for fine-tuning the regulation of SF-1-dependent genes in multiple target tissues. gata 33-37 splicing factor 1 Homo sapiens 124-128 11259267-9 2001 Because we have shown that other GATA family members also have the ability to synergize with SF-1, Dax-1 repression of GATA/SF-1 synergism may represent an important mechanism for fine-tuning the regulation of SF-1-dependent genes in multiple target tissues. gata 33-37 splicing factor 1 Homo sapiens 124-128 11156886-4 2001 Gel mobility shift assays were used to analyze the trans-acting factors that interact with the GATA motifs of the BNP promoter. gata 95-99 natriuretic peptide B Rattus norvegicus 114-117 11073899-2 2000 In addition to the GATA sequences situated upstream of all nitrogen catabolite repression-sensitive genes that encode enzyme and transport proteins, the promoters of the GAT1, DAL80, and DEH1 genes all contain multiple GATA sequences as well. gata 219-223 Gat1p Saccharomyces cerevisiae S288C 170-174 11016926-6 2001 The functional cooperation between GATA-1 and PKC-epsilon displayed dependence on cellular milieu, as well as on the promoter context of GATA binding sites. gata 35-39 protein kinase C epsilon Homo sapiens 46-57 11073899-2 2000 In addition to the GATA sequences situated upstream of all nitrogen catabolite repression-sensitive genes that encode enzyme and transport proteins, the promoters of the GAT1, DAL80, and DEH1 genes all contain multiple GATA sequences as well. gata 219-223 Dal80p Saccharomyces cerevisiae S288C 176-181 11073899-2 2000 In addition to the GATA sequences situated upstream of all nitrogen catabolite repression-sensitive genes that encode enzyme and transport proteins, the promoters of the GAT1, DAL80, and DEH1 genes all contain multiple GATA sequences as well. gata 219-223 Gzf3p Saccharomyces cerevisiae S288C 187-191 10906145-2 2000 Gln3p binds to and Gat1p is proposed to bind to single GATA sequences; Dal80p binds to pairs of specifically oriented and spaced GATA sequences, and Dal82p binds to a pathway-specific element, UIS(ALL). gata 129-133 Dal80p Saccharomyces cerevisiae S288C 71-77 10788492-5 2000 Stimulation by phenylephrine caused serine phosphorylation of GATA-4 and increased its ability to bind the ET-1 GATA element. gata 62-66 endothelin 1 Rattus norvegicus 107-111 10862620-5 2000 The GATA motifs bound GATA-1 and mutagenesis analysis revealed that the proximal one is critical for the enhancing activity. gata 4-8 GATA binding protein 1 Homo sapiens 22-28 10851229-4 2000 Here, we show that GATA-6 bound to a GATA-like motif (-810/-805) within the rat Sm-MHC promoter in a sequence-specific manner and activated this promoter through this site. gata 19-23 myosin heavy chain 11 Rattus norvegicus 80-86 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 0-4 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 24-29 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 0-4 Gat1p Saccharomyces cerevisiae S288C 34-39 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 0-4 Dal80p Saccharomyces cerevisiae S288C 57-63 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 0-4 Gzf3p Saccharomyces cerevisiae S288C 68-73 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 221-225 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 24-29 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 221-225 Gat1p Saccharomyces cerevisiae S288C 34-39 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 221-225 Dal80p Saccharomyces cerevisiae S288C 57-63 10799523-1 2000 GATA family activators (Gln3p and Gat1p) and repressors (Dal80p and Deh1p) regulate nitrogen catabolite repression (NCR)-sensitive transcription in Saccharomyces cerevisiae presumably via their competitive binding to the GATA sequences upstream of NCR-sensitive genes. gata 221-225 Gzf3p Saccharomyces cerevisiae S288C 68-73 10788492-3 2000 Using transient transfection assays in primary cardiac myocytes from neonatal rats, we show here that the GATA element in the rat ET-1 promoter was required for phenylephrine-stimulated ET-1 transcription. gata 106-110 endothelin 1 Rattus norvegicus 130-134 10788492-3 2000 Using transient transfection assays in primary cardiac myocytes from neonatal rats, we show here that the GATA element in the rat ET-1 promoter was required for phenylephrine-stimulated ET-1 transcription. gata 106-110 endothelin 1 Rattus norvegicus 186-190 10625644-3 2000 In this work, a consensus GATA-binding site (GBS) was identified at positions -69 to -64 of the mouse SP-A gene. gata 26-30 surfactant associated protein A1 Mus musculus 102-106 10588863-5 1999 GATA-dependent regulatory sequences of the Nkx2.5 gene that implicate GATA-4/5/6 as upstream positive regulators were described recently. gata 0-4 NK2 homeobox 5 S homeolog Xenopus laevis 43-49 10588863-5 1999 GATA-dependent regulatory sequences of the Nkx2.5 gene that implicate GATA-4/5/6 as upstream positive regulators were described recently. gata 0-4 GATA binding protein 4 L homeolog Xenopus laevis 70-76 10559172-1 1999 Dal82p binds to the UIS(ALL) sites of allophanate-induced genes of the allantoin-degradative pathway and functions synergistically with the GATA family Gln3p and Gat1p transcriptional activators that are responsible for nitrogen catabolite repression-sensitive gene expression. gata 140-144 Dal82p Saccharomyces cerevisiae S288C 0-6 10559172-1 1999 Dal82p binds to the UIS(ALL) sites of allophanate-induced genes of the allantoin-degradative pathway and functions synergistically with the GATA family Gln3p and Gat1p transcriptional activators that are responsible for nitrogen catabolite repression-sensitive gene expression. gata 140-144 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 152-157 10559172-8 1999 This synergism is unlike all other known instances of Dal82p synergism, namely, that with the GATA family transcription activators Gln3p and Gat1p, which occurs only in the presence of an inducer. gata 94-98 Dal82p Saccharomyces cerevisiae S288C 54-60 10559172-8 1999 This synergism is unlike all other known instances of Dal82p synergism, namely, that with the GATA family transcription activators Gln3p and Gat1p, which occurs only in the presence of an inducer. gata 94-98 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 131-136 10523648-3 1999 We found that an HS2 element mutated in its GATA motif failed to remodel the epsilon-globin promoter or activate transcription yet HS2 nuclease accessibility did not change. gata 44-48 spectrin beta, erythrocytic Homo sapiens 17-20 10501969-7 1999 Functional studies with recombinant GATA-4, -5, and -6 proteins show that GATA-5 has preferential affinity for a subset of GATA elements found on cardiac promoters and differentially activate cardiac gene transcription. gata 36-40 GATA binding protein 5 Rattus norvegicus 74-80 10514435-7 1999 In vivo deletion and site-directed mutation analyses confirm that one GATA element in mtl-1 and two in mtl-2 are required for transcription. gata 70-74 Metallothionein-1 Caenorhabditis elegans 86-91 10514435-11 1999 These results indicate that cell-specific transcription of the C. elegans metallothionein genes is regulated by the binding of ELT-2 to GATA elements in these promoters. gata 136-140 Transcription factor elt-2 Caenorhabditis elegans 127-132 10597043-1 1999 The Caenorhabditis elegans ELT-1 protein, a homolog of the vertebrate GATA transcription factor family, is a transcription activator that can recognize the GATA motif. gata 70-74 Transcription factor elt-1 Caenorhabditis elegans 27-32 10597043-6 1999 To investigate the possible target genes for the ELT-1 protein in the germ line, the ELT-1 protein was expressed and tested for its binding specificity to the GATA motif that is present in the promoter region of the C. elegans major sperm protein genes. gata 159-163 Transcription factor elt-1 Caenorhabditis elegans 49-54 10597043-6 1999 To investigate the possible target genes for the ELT-1 protein in the germ line, the ELT-1 protein was expressed and tested for its binding specificity to the GATA motif that is present in the promoter region of the C. elegans major sperm protein genes. gata 159-163 Transcription factor elt-1 Caenorhabditis elegans 85-90 10597043-8 1999 Mutational analysis showed that the GATC core sequence was necessary for strong transactivation of the reporter gene, and that the combination of GATC and GATA motif resulted in a stronger transactivation by ELT-1 than either the duplicated GATC or GATA motif. gata 155-159 Transcription factor elt-1 Caenorhabditis elegans 208-213 10597043-8 1999 Mutational analysis showed that the GATC core sequence was necessary for strong transactivation of the reporter gene, and that the combination of GATC and GATA motif resulted in a stronger transactivation by ELT-1 than either the duplicated GATC or GATA motif. gata 249-253 Transcription factor elt-1 Caenorhabditis elegans 208-213 9834187-0 1999 Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. gata 63-67 NK2 homeobox 5 Mus musculus 51-57 10524205-4 1999 Transcriptional reporter assays in Ba/F3 cells revealed that two AP-1 sites, a GATA motif, and an Ets site are required for induction of DUB-1 enhancer activity. gata 79-83 ubiquitin specific peptidase 17-like A Mus musculus 137-142 10438731-3 1999 Further analysis of the MBP promoter region identified a C/EBP (CCAAT/enhancer-binding protein) consensus binding site 6 bp upstream of the functional GATA-binding site in the MBP gene. gata 151-155 myelin basic protein Homo sapiens 24-27 10438731-3 1999 Further analysis of the MBP promoter region identified a C/EBP (CCAAT/enhancer-binding protein) consensus binding site 6 bp upstream of the functional GATA-binding site in the MBP gene. gata 151-155 myelin basic protein Homo sapiens 176-179 10438731-6 1999 Furthermore, we have demonstrated that both C/EBPbeta and GATA-1 can bind simultaneously to the C/EBP- and GATA-binding sites in the MBP promoter. gata 58-62 myelin basic protein Homo sapiens 133-136 10395794-10 1999 Electrophoretic mobility shift assay revealed that GATA-1 could bind to the -29/-24 GATA motif and this was confirmed by the observation that the nuclear protein bound to the motif was supershifted by an anti-GATA-1 monoclonal antibody. gata 51-55 GATA binding protein 1 Mus musculus 209-215 10207004-7 1999 The upstream sequence of the cloned PGRP gene was shown to contain putative cis-regulatory elements similar to the NF-kappaB-like element, interferon-response half-element, and GATA motif element, which have been found in the promoters of the acute phase protein genes of mammals and insects. gata 177-181 peptidoglycan recognition protein Bombyx mori 36-40 10075997-2 1999 Previous functional analysis demonstrated that the repression of the GPB promoter is determined by the binding of a ubiquitous factor which recognizes a GATA motif centered at position -75. gata 153-157 glycophorin B (MNS blood group) Homo sapiens 69-72 10075997-4 1999 Here, we have identified the Ku70 protein as a candidate GPB repressor DNA binding subunit through the screening of a human HeLa expression library using the -75 GATA sequence as bait (one-hybrid method). gata 162-166 X-ray repair cross complementing 6 Homo sapiens 29-33 10075997-4 1999 Here, we have identified the Ku70 protein as a candidate GPB repressor DNA binding subunit through the screening of a human HeLa expression library using the -75 GATA sequence as bait (one-hybrid method). gata 162-166 glycophorin B (MNS blood group) Homo sapiens 57-60 9834187-9 1999 These results reveal a novel GATA-dependent mechanism for activation of Nkx2-5 transcription in the developing heart and indicate that regulation of Nkx2-5 is controlled in a modular manner, with multiple regulatory regions responding to distinct transcriptional networks in different compartments of the developing heart. gata 29-33 NK2 homeobox 5 Mus musculus 72-78 9834187-9 1999 These results reveal a novel GATA-dependent mechanism for activation of Nkx2-5 transcription in the developing heart and indicate that regulation of Nkx2-5 is controlled in a modular manner, with multiple regulatory regions responding to distinct transcriptional networks in different compartments of the developing heart. gata 29-33 NK2 homeobox 5 Mus musculus 149-155 9693032-2 1998 The NOTCH4 locus contains a TATA-less promoter with two putative transcription initiation sites (Inr), three RBP-Jkappa sites, and two GATA recognition sites. gata 135-139 notch receptor 4 Homo sapiens 4-10 9737959-5 1998 Although this conserved element imparts high level transcription to a heterologous promoter in all lines examined, erythroid specificity is retained only when it is fused to the proximal EKLF promoter, which contains an important GATA site. gata 230-234 Kruppel like factor 1 Homo sapiens 187-191 9819382-7 1998 Promoter analysis revealed that a GATA site in a cryptic promoter in the second intron was essential and sufficient for the TAL1- and LMO-dependent transcriptional activation, and GATA3 binds to this site. gata 34-38 T cell acute lymphocytic leukemia 1 Mus musculus 124-128 9819382-7 1998 Promoter analysis revealed that a GATA site in a cryptic promoter in the second intron was essential and sufficient for the TAL1- and LMO-dependent transcriptional activation, and GATA3 binds to this site. gata 34-38 GATA binding protein 3 Mus musculus 180-185 9791119-2 1998 Thus far, Gln3p, Dal80p, and Deh1p have been shown to bind to GATA sequences in NCR-sensitive promoters, in some cases to exactly the same GATA sequences. gata 62-66 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 10-15 9791119-2 1998 Thus far, Gln3p, Dal80p, and Deh1p have been shown to bind to GATA sequences in NCR-sensitive promoters, in some cases to exactly the same GATA sequences. gata 62-66 Dal80p Saccharomyces cerevisiae S288C 17-23 9791119-2 1998 Thus far, Gln3p, Dal80p, and Deh1p have been shown to bind to GATA sequences in NCR-sensitive promoters, in some cases to exactly the same GATA sequences. gata 62-66 Gzf3p Saccharomyces cerevisiae S288C 29-34 9791119-2 1998 Thus far, Gln3p, Dal80p, and Deh1p have been shown to bind to GATA sequences in NCR-sensitive promoters, in some cases to exactly the same GATA sequences. gata 139-143 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 10-15 9791119-2 1998 Thus far, Gln3p, Dal80p, and Deh1p have been shown to bind to GATA sequences in NCR-sensitive promoters, in some cases to exactly the same GATA sequences. gata 139-143 Dal80p Saccharomyces cerevisiae S288C 17-23 9791119-2 1998 Thus far, Gln3p, Dal80p, and Deh1p have been shown to bind to GATA sequences in NCR-sensitive promoters, in some cases to exactly the same GATA sequences. gata 139-143 Gzf3p Saccharomyces cerevisiae S288C 29-34 9753664-6 1998 Consistent with this postulation, we found that the promoter region of the isolated BMP-4 genomic DNA includes several consensus binding sites for transcriptional regulators functioning under BMP-4 signaling such as GATA binding and ventralizing homeobox genes. gata 216-220 bone morphogenetic protein 4 L homeolog Xenopus laevis 84-89 9753664-6 1998 Consistent with this postulation, we found that the promoter region of the isolated BMP-4 genomic DNA includes several consensus binding sites for transcriptional regulators functioning under BMP-4 signaling such as GATA binding and ventralizing homeobox genes. gata 216-220 bone morphogenetic protein 4 L homeolog Xenopus laevis 192-197 9753664-7 1998 In a functional assay we found that the GATA binding and ventral homeobox proteins can positively modulate BMP-4 promoter activity. gata 40-44 bone morphogenetic protein 4 L homeolog Xenopus laevis 107-112 9724651-2 1998 Using immunoprecipitation of genomic fragments bound to TAL-1 in the chromatin of murine erythro-leukemia (MEL) cells, we found that 10% of the immunoselected fragments contained a CAGATG or a CAGGTG E-box, followed by a GATA site. gata 221-225 T cell acute lymphocytic leukemia 1 Mus musculus 56-61 9724651-3 1998 We studied one of these fragments containing two E-boxes, CAGATG and CAGGTC, followed by a GATA motif, and showed that TAL-1 binds to the CAGGTG E-box with an affinity modulated by the CAGATG or the GATA site, and that the CAGGTG-GATA motif exhibits positive transcriptional activity in MEL but not in HeLa cells. gata 91-95 TAL bHLH transcription factor 1, erythroid differentiation factor Homo sapiens 119-124 9724651-3 1998 We studied one of these fragments containing two E-boxes, CAGATG and CAGGTC, followed by a GATA motif, and showed that TAL-1 binds to the CAGGTG E-box with an affinity modulated by the CAGATG or the GATA site, and that the CAGGTG-GATA motif exhibits positive transcriptional activity in MEL but not in HeLa cells. gata 199-203 TAL bHLH transcription factor 1, erythroid differentiation factor Homo sapiens 119-124 9724651-3 1998 We studied one of these fragments containing two E-boxes, CAGATG and CAGGTC, followed by a GATA motif, and showed that TAL-1 binds to the CAGGTG E-box with an affinity modulated by the CAGATG or the GATA site, and that the CAGGTG-GATA motif exhibits positive transcriptional activity in MEL but not in HeLa cells. gata 199-203 TAL bHLH transcription factor 1, erythroid differentiation factor Homo sapiens 119-124 9724651-6 1998 These results establish that TAL-1 is likely to activate its target genes through a complex that binds an E-box-GATA motif and define the first gene regulated by TAL-1. gata 112-116 TAL bHLH transcription factor 1, erythroid differentiation factor Homo sapiens 29-34 9642238-10 1998 The GATA motif bound GATA-1 in vitro. gata 4-8 GATA binding protein 1 Homo sapiens 21-27 9634475-8 1998 In particular, a GATA/c-Ets motive was identified in a short segment homologous to the mouse CD4 distal enhancer, suggesting that LAG-3, which is embedded in the CD4 locus, may be controlled by some CD4 regulatory elements. gata 17-21 CD4 antigen Mus musculus 93-96 9634475-8 1998 In particular, a GATA/c-Ets motive was identified in a short segment homologous to the mouse CD4 distal enhancer, suggesting that LAG-3, which is embedded in the CD4 locus, may be controlled by some CD4 regulatory elements. gata 17-21 lymphocyte-activation gene 3 Mus musculus 130-135 9571201-4 1998 Within the 5" flanking region we identified a putative binding site for NRF-2, a GATA- and GC-box element. gata 81-85 NFE2 like bZIP transcription factor 2 Homo sapiens 72-77 9634475-8 1998 In particular, a GATA/c-Ets motive was identified in a short segment homologous to the mouse CD4 distal enhancer, suggesting that LAG-3, which is embedded in the CD4 locus, may be controlled by some CD4 regulatory elements. gata 17-21 CD4 antigen Mus musculus 162-165 9634475-8 1998 In particular, a GATA/c-Ets motive was identified in a short segment homologous to the mouse CD4 distal enhancer, suggesting that LAG-3, which is embedded in the CD4 locus, may be controlled by some CD4 regulatory elements. gata 17-21 CD4 antigen Mus musculus 162-165 9659934-1 1998 The Caenorhabditis elegans elt-2 gene encodes a single-finger GATA factor, previously cloned by virtue of its binding to a tandem pair of GATA sites that control the gut-specific ges-1 esterase gene. gata 62-66 Transcription factor elt-2 Caenorhabditis elegans 27-32 9659934-1 1998 The Caenorhabditis elegans elt-2 gene encodes a single-finger GATA factor, previously cloned by virtue of its binding to a tandem pair of GATA sites that control the gut-specific ges-1 esterase gene. gata 62-66 Gut esterase 1 Caenorhabditis elegans 179-184 9600835-7 1998 Cloning of the metchnikowin gene revealed the presence in the 5" flanking region of several putative cis-regulatory motifs characterized in the promoters of insect immune genes: namely, Rel sites, GATA motifs, interferon consensus response elements and NF-IL6 response elements. gata 197-201 Metchnikowin Drosophila melanogaster 15-27 9628819-3 1998 Several putative transcription factor-binding sites were identified in each of the urocortin promoters, including a TATA box, a cyclic AMP response element (CRE), GATA-binding sites, and a C/EBP-binding site as well as a Brn-2-binding site(s). gata 163-167 urocortin Homo sapiens 83-92 9486185-5 1998 Mutational analysis of the LUE demonstrated that bases contained within a GATA consensus motif are critical for both CCP binding and transcription from the LPH promoter. gata 74-78 lactase Homo sapiens 156-159 9498775-11 1998 Taken together, our results provide evidence that GATA-related factors may be involved in Th2-specific expression of the IL-5 gene. gata 50-54 heart and neural crest derivatives expressed 2 Mus musculus 90-93 9498775-11 1998 Taken together, our results provide evidence that GATA-related factors may be involved in Th2-specific expression of the IL-5 gene. gata 50-54 interleukin 5 Mus musculus 121-125 9473510-8 1998 The core promoter of RH50 gene was located within 68bp length from the translation start position, which included an inverse GATA motif, although obvious motifs for Sp1 or erythroid Kruppel-like factor were lacking. gata 125-129 Rh associated glycoprotein Homo sapiens 21-25 9305891-2 1997 The P1 region of the mouse TSHbeta promoter (-133 to -88) region interacts with Pit-1 and an additional 50-kDa factor at an adjacent site that resembles a consensus GATA binding site. gata 165-169 thyroid stimulating hormone, beta subunit Mus musculus 27-34 9403619-10 1997 A GATA element within beta-MHC sequences -303/-197 plays a role in the transcriptional activation of this gene by aortic constriction. gata 2-6 myosin heavy chain 7 Rattus norvegicus 22-30 9761670-0 1998 Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. gata 91-95 Gut-specific cysteine proteinase Caenorhabditis elegans 68-73 9761670-6 1998 A concatemer of the cpr-1 -147 GATA motif placed upstream of minimal promoter/lac Z reporter gene constructs results in strong reporter gene expression in gut cells of larval stages and also in embryos. gata 31-35 Gut-specific cysteine proteinase Caenorhabditis elegans 20-25 9401021-2 1997 All four proteins contain GATA-type zinc finger domains, and three of them (Gln3p, Dal80p, and Deh1p) have been shown to bind to GATA sequences situated upstream of genes whose expression is sensitive to nitrogen catabolite repression (NCR). gata 26-30 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 76-81 9401021-2 1997 All four proteins contain GATA-type zinc finger domains, and three of them (Gln3p, Dal80p, and Deh1p) have been shown to bind to GATA sequences situated upstream of genes whose expression is sensitive to nitrogen catabolite repression (NCR). gata 26-30 Dal80p Saccharomyces cerevisiae S288C 83-89 9401021-2 1997 All four proteins contain GATA-type zinc finger domains, and three of them (Gln3p, Dal80p, and Deh1p) have been shown to bind to GATA sequences situated upstream of genes whose expression is sensitive to nitrogen catabolite repression (NCR). gata 26-30 Gzf3p Saccharomyces cerevisiae S288C 95-100 9249061-3 1997 Putative transcription factor binding sites that might be significant for THBS2 regulation included p53, NF-kappaB, Spl, Myc-CF1, NF-Y, CF1, AP1, and GATA sites. gata 150-154 thrombospondin 2 Homo sapiens 74-79 9231805-11 1997 In light of these findings, the established role of other GATA-binding proteins in hematopoetic cell differentiation and apoptosis, and the presence of conserved GATA motifs in the promoters of genes expressed selectively in ovary, we propose that GATA-4 and GATA-6 play distinct roles in follicular development and luteinization. gata 58-62 GATA binding protein 4 Mus musculus 248-254 9231805-11 1997 In light of these findings, the established role of other GATA-binding proteins in hematopoetic cell differentiation and apoptosis, and the presence of conserved GATA motifs in the promoters of genes expressed selectively in ovary, we propose that GATA-4 and GATA-6 play distinct roles in follicular development and luteinization. gata 162-166 GATA binding protein 4 Mus musculus 248-254 9211887-9 1997 Contained in this region is a consensus GATA motif, suggesting that a member of the GATA family of DNA-binding proteins is involved in the cell-specific regulation of the GIP gene. gata 40-44 gastric inhibitory polypeptide Mus musculus 171-174 9125153-4 1997 Reverse-transcription PCR using dissected nephron segments revealed that rat GATA-3 but not GATA-2 was expressed in collecting ducts, thus indicating that GATA-3 could interact with GATA motifs in the AQP-2 promoter. gata 77-81 GATA binding protein 3 Rattus norvegicus 155-161 9125153-4 1997 Reverse-transcription PCR using dissected nephron segments revealed that rat GATA-3 but not GATA-2 was expressed in collecting ducts, thus indicating that GATA-3 could interact with GATA motifs in the AQP-2 promoter. gata 77-81 aquaporin 2 Rattus norvegicus 201-206 9028940-8 1997 An electrophoretic mobility shift assay (EMSA) showed that in EPO-stimulated UT-7 cells, the dynamic changes in EPOR gene expression paralleled the GATA-1 DNA-binding activity to the oligonucleotide probe containing a GATA-binding site located at the promoter region of the EPOR gene. gata 148-152 erythropoietin Homo sapiens 62-65 9028940-8 1997 An electrophoretic mobility shift assay (EMSA) showed that in EPO-stimulated UT-7 cells, the dynamic changes in EPOR gene expression paralleled the GATA-1 DNA-binding activity to the oligonucleotide probe containing a GATA-binding site located at the promoter region of the EPOR gene. gata 148-152 erythropoietin receptor Homo sapiens 112-116 7760810-7 1995 ER-mediated repression of GATA-1 activity occurs on an artificial promoter containing a single GATA-binding site, as well as in the context of an intact promoter which is normally regulated by GATA-1. gata 26-30 GATA binding protein 1 Homo sapiens 193-199 8977242-8 1996 Although our functional approach does not yet indicate the precise sequences required for erythroid induction, the AE1 gene upstream region contains potential GATA sites at -154, -141, and -60; an E-box at -163; CACCC or GGTGG motifs at -188, -121, and -88; and an AP-1/NF-E2-like site at -42. gata 159-163 solute carrier family 4 (anion exchanger), member 1 Mus musculus 115-118 8901135-2 1996 An E. coli-expressed NIT2/beta-Gal fusion protein binds specifically to DNA in vitro by recognizing GATA core elements. gata 100-104 nitrilase family, member 2 Mus musculus 21-25 8901135-4 1996 The native NIT2 protein in nuclear extracts binds with high affinity to DNA fragments which contain two GATA elements, weakly to fragments with a single GATA element, and fails to bind to DNAs which lack these sequences. gata 104-108 nitrilase family, member 2 Mus musculus 11-15 8901135-4 1996 The native NIT2 protein in nuclear extracts binds with high affinity to DNA fragments which contain two GATA elements, weakly to fragments with a single GATA element, and fails to bind to DNAs which lack these sequences. gata 153-157 nitrilase family, member 2 Mus musculus 11-15 7568152-0 1995 Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. gata 12-16 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 25-30 8690723-4 1995 Deletion analysis of the distal GATA site and its neighboring sequence and DNase-I footprinting/EMSA (electrophoretic mobility shift assay) analysis indicated that induced nuclear factor binding to GATA-1 and its neighboring sequence may be required for expression during MEL cell differentiation induced by dimethyl sulfoxide treatment. gata 32-36 GATA binding protein 1 Mus musculus 198-204 7782329-3 1995 The longest open reading frame in the elt-2 cDNA codes for a protein of M(r) 47,000 with a single zinc finger domain, similar (approximately 75% amino acid identity) to the C-terminal fingers of all other two-fingered GATA factors isolated to date. gata 218-222 Transcription factor elt-2 Caenorhabditis elegans 38-43 7782329-5 1995 An upstream region in the ELT-2 protein with the sequence C-X2-C-X16-C-X2-C has some of the characteristics of a zinc finger domain but is highly diverged from the zinc finger domains of other GATA factors. gata 193-197 Transcription factor elt-2 Caenorhabditis elegans 26-31 7782329-7 1995 The genomic clone for elt-2 has been characterized and mapped near the center of the C. elegans X chromosome, ELT-2 protein, produced by in vitro transcription-translation, binds to ges-1 GATA-containing oligonucleotides similar to a factor previously identified in C. elegans embryo extracts, both as assayed by electrophoretic migration and by competition with wild type and mutant oligonucleotides. gata 188-192 Transcription factor elt-2 Caenorhabditis elegans 22-27 7782329-7 1995 The genomic clone for elt-2 has been characterized and mapped near the center of the C. elegans X chromosome, ELT-2 protein, produced by in vitro transcription-translation, binds to ges-1 GATA-containing oligonucleotides similar to a factor previously identified in C. elegans embryo extracts, both as assayed by electrophoretic migration and by competition with wild type and mutant oligonucleotides. gata 188-192 Transcription factor elt-2 Caenorhabditis elegans 110-115 7782329-7 1995 The genomic clone for elt-2 has been characterized and mapped near the center of the C. elegans X chromosome, ELT-2 protein, produced by in vitro transcription-translation, binds to ges-1 GATA-containing oligonucleotides similar to a factor previously identified in C. elegans embryo extracts, both as assayed by electrophoretic migration and by competition with wild type and mutant oligonucleotides. gata 188-192 Gut esterase 1 Caenorhabditis elegans 182-187 8896456-2 1996 In this study, we characterize an essential upstream IL-2 response element that contains both consensus and non-consensus GAS motifs, two putative Ets binding sites (EBS), one of which overlaps the consensus GAS motif, and a GATA motif, which overlaps the non-consensus GAS motif. gata 225-229 interleukin 2 Homo sapiens 53-57 8703016-9 1996 The mutation changes a GATA consensus binding site, disrupts GATA-1 binding to the mutated site, and decreases promoter activity by 84%. gata 23-27 GATA binding protein 1 Homo sapiens 61-67 11012226-7 1996 GATA-1 binds with low affinity to a unique GATA motif at -70 in the MPL promoter, and destruction of this site yields only a modest decrease in expression level in human erythroleukemia (HEL) cells. gata 0-4 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 68-71 7473742-1 1995 The GATA motif (WGATAR) is found in the promoter regions of numerous Caenorhabditis elegans genes, including two intestine-specific genes, vit-2 and ges-1, in which it has been shown to be required for promoter function. gata 4-8 Vitellogenin-2 Caenorhabditis elegans 139-144 7473742-1 1995 The GATA motif (WGATAR) is found in the promoter regions of numerous Caenorhabditis elegans genes, including two intestine-specific genes, vit-2 and ges-1, in which it has been shown to be required for promoter function. gata 4-8 Gut esterase 1 Caenorhabditis elegans 149-154 7473742-9 1995 The deleted ELT-1 protein containing only the C-terminal Zn finger was sufficient for activation in response to GATA, but both fingers were required for activation at GATC. gata 112-116 Transcription factor elt-1 Caenorhabditis elegans 12-17 7639699-8 1995 In addition, sequences described in the Drosophila melanogaster Sgs-3 gene as being involved in its salivary gland-specific expression as well as two putative OTF- and GATA-binding elements were also found. gata 168-172 Salivary gland secretion 3 Drosophila melanogaster 64-69 7649372-0 1995 A gut-to-pharynx/tail switch in embryonic expression of the Caenorhabditis elegans ges-1 gene centers on two GATA sequences. gata 109-113 Gut esterase 1 Caenorhabditis elegans 83-88 7890725-7 1995 Gel shift competition experiments and transactivation studies revealed that this functional activity is mediated via binding at a GATA-binding site in the WT1 enhancer. gata 130-134 WT1 transcription factor Homo sapiens 155-158 7717974-4 1995 Gel-shift experiments and antibody binding studies demonstrate that: (1) GATA-4 is the major GATA-binding protein activity in differentiated F9 cells, and (2) GATA-4 binds to consensus GATA motifs in the retinoic acid-responsive portion of the J6 promoter. gata 73-77 GATA binding protein 4 Mus musculus 159-165 8045902-2 1994 The deduced sequences of the DAL80 and GLN3 proteins contain a zinc finger motif homologous to those shown to bind GATA sequences. gata 115-119 Dal80p Saccharomyces cerevisiae S288C 29-34 7853477-5 1995 Two of the required elements, GATA (at -114) and CACGTG (at -104), were previously shown to specifically bind host transcription factors and activate transcription from the TATA-dependent wild-type gp64 efp promoter. gata 30-34 gp64 Orgyia pseudotsugata multiple nucleopolyhedrovirus 198-202 7808401-2 1994 NIT2 binding sites in the promoter regions of nit3, alc and lao have at least two GATA sequence elements. gata 82-86 putative hydrolase Saccharomyces cerevisiae S288C 0-4 7808401-3 1994 We have examined the binding affinity of the NIT2 protein for the yeast DAL5 wild-type upstream activation sequence UASNTR, which contains two GATA elements, and for a series of mutated binding sites, each differing from the wild-type site by a single base. gata 143-147 putative hydrolase Saccharomyces cerevisiae S288C 45-49 7808401-5 1994 In contrast, nearly all substitutions within the GATA elements almost completely eliminated NIT2 binding, demonstrating the importance of the GATA sequence for NIT2 binding. gata 49-53 putative hydrolase Saccharomyces cerevisiae S288C 92-96 7808401-5 1994 In contrast, nearly all substitutions within the GATA elements almost completely eliminated NIT2 binding, demonstrating the importance of the GATA sequence for NIT2 binding. gata 49-53 putative hydrolase Saccharomyces cerevisiae S288C 160-164 7808401-5 1994 In contrast, nearly all substitutions within the GATA elements almost completely eliminated NIT2 binding, demonstrating the importance of the GATA sequence for NIT2 binding. gata 142-146 putative hydrolase Saccharomyces cerevisiae S288C 92-96 7808401-5 1994 In contrast, nearly all substitutions within the GATA elements almost completely eliminated NIT2 binding, demonstrating the importance of the GATA sequence for NIT2 binding. gata 142-146 putative hydrolase Saccharomyces cerevisiae S288C 160-164 8045902-2 1994 The deduced sequences of the DAL80 and GLN3 proteins contain a zinc finger motif homologous to those shown to bind GATA sequences. gata 115-119 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 39-43 8045902-4 1994 We demonstrate here that the GATA-containing sites upstream of UGA4 required for optimal GLN3-dependent transcriptional activation also mediate DAL80 protein binding in vitro and DAL80-responsive regulation in vivo. gata 29-33 Uga4p Saccharomyces cerevisiae S288C 63-67 8045902-4 1994 We demonstrate here that the GATA-containing sites upstream of UGA4 required for optimal GLN3-dependent transcriptional activation also mediate DAL80 protein binding in vitro and DAL80-responsive regulation in vivo. gata 29-33 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 89-93 8045902-4 1994 We demonstrate here that the GATA-containing sites upstream of UGA4 required for optimal GLN3-dependent transcriptional activation also mediate DAL80 protein binding in vitro and DAL80-responsive regulation in vivo. gata 29-33 Dal80p Saccharomyces cerevisiae S288C 144-149 8045902-4 1994 We demonstrate here that the GATA-containing sites upstream of UGA4 required for optimal GLN3-dependent transcriptional activation also mediate DAL80 protein binding in vitro and DAL80-responsive regulation in vivo. gata 29-33 Dal80p Saccharomyces cerevisiae S288C 179-184 8400237-8 1993 The CLC promoter sequence contains two consensus GATA binding sites, a purine-rich sequence that presents potential binding sites for PU.1, a member of the ets family of genes, as well as sequences described in other myeloid-specific promoters. gata 49-53 Charcot-Leyden crystal galectin Homo sapiens 4-7 8007990-5 1994 We recently found two putative GATA-binding sites within the proximal enhancer of the alpha-MHC gene, suggesting that GATA-4 might regulate its expression. gata 31-35 myosin heavy chain 6 Homo sapiens 86-95 8007990-5 1994 We recently found two putative GATA-binding sites within the proximal enhancer of the alpha-MHC gene, suggesting that GATA-4 might regulate its expression. gata 31-35 GATA binding protein 4 Homo sapiens 118-124 8007990-6 1994 In this study, we establish that GATA-4 interacts with the alpha-MHC GATA sites to stimulate cardiac muscle-specific expression. gata 33-37 myosin heavy chain 6 Homo sapiens 59-68 8007990-8 1994 GATA-4-dependent enhancement of activity from a heterologous promoter was mediated through the alpha-MHC GATA sites. gata 0-4 myosin heavy chain 6 Homo sapiens 95-104 8200477-6 1994 Factors that bind to double-stranded oligonucleotides containing the ges-1 GATA sequences are present predominantly in nuclear extracts of embryos but are found neither in cytoplasmic nor in nuclear extracts of unfertilized oocytes. gata 75-79 Gut esterase 1 Caenorhabditis elegans 69-74 8200477-7 1994 Two proteins, of 43 and 60 kDa, can be uv-crosslinked to double-stranded oligonucleotides containing the ges-1 GATA sequences. gata 111-115 Gut esterase 1 Caenorhabditis elegans 105-110 8164667-5 1994 Cloning and functional analysis of the rat BNP upstream sequences revealed unexpected structural resemblance to erythroid but not to muscle-specific promoters and enhancers, including a requirement for regulatory elements containing GATA motifs. gata 233-237 natriuretic peptide B Rattus norvegicus 43-46 8164667-8 1994 Within the heart, GATA transcripts are localized in ANP- and BNP-expressing myocytes, and forced expression of the GATA protein in heterologous cells markedly activates transcription from the natural cardiac muscle-specific ANP and BNP promoters. gata 18-22 natriuretic peptide B Rattus norvegicus 61-64 8027030-5 1994 Upon isolating and sequencing 2.5 kilobases of the rat BNP 5"-flanking sequence (FS), a variety of putative transcriptional enhancer sites were identified, including several GATA consensus sequences (WGATAR), one of which apparently serves as the major promoter site. gata 174-178 natriuretic peptide B Rattus norvegicus 55-58 8027030-7 1994 Truncation analyses showed that inducibility mapped primarily to the proximal -116 base pair of the rat BNP 5"-FS, where there are two consensus GATA sites in addition to the GATA sequence at the TATA box. gata 145-149 natriuretic peptide B Rattus norvegicus 104-107 8027030-7 1994 Truncation analyses showed that inducibility mapped primarily to the proximal -116 base pair of the rat BNP 5"-FS, where there are two consensus GATA sites in addition to the GATA sequence at the TATA box. gata 175-179 natriuretic peptide B Rattus norvegicus 104-107 8027030-8 1994 Point mutation analyses showed that at least one of the GATA sites was required to confer full GATA-4-inducible transcription. gata 56-60 GATA binding protein 4 Rattus norvegicus 95-101 8027030-9 1994 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata 105-109 natriuretic peptide B Rattus norvegicus 60-63 8027030-9 1994 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata 105-109 natriuretic peptide B Rattus norvegicus 164-167 8027030-9 1994 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata 201-205 natriuretic peptide B Rattus norvegicus 60-63 8027030-9 1994 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata 201-205 myotrophin Rattus norvegicus 86-99 8027030-9 1994 These results demonstrate that a proximal region of the rat BNP 5"-FS is required for growth factor- and GATA-inducible transcription, supporting the view that the BNP gene could serve as a target for GATA-binding proteins during early cardiac development. gata 201-205 natriuretic peptide B Rattus norvegicus 164-167 8150083-3 1994 These complexes bind to GATA motifs of the rho-globin promoter and histone H5 enhancer with high affinity, and to the chicken beta-globin promoter specialized TATA element and enhancer GATA with low affinity. gata 24-28 hemoglobin beta, subunit rho Gallus gallus 43-53 8150083-3 1994 These complexes bind to GATA motifs of the rho-globin promoter and histone H5 enhancer with high affinity, and to the chicken beta-globin promoter specialized TATA element and enhancer GATA with low affinity. gata 185-189 hemoglobin beta, subunit rho Gallus gallus 43-53 8370527-5 1993 We find that TBP (TATA-binding protein) alone can activate transcription of beta-globin chromatin templates from promoters mutated to a canonical TATA box but is ineffective on those containing the normal -30 GATA site. gata 209-213 TATA-box binding protein Gallus gallus 13-16 8449904-9 1993 Mutations and deletions of both sites indicate that only the association of CCACC/Sp1 and GATA binding sites can drive efficient and tissue-specific expression of this R-PK minimal promoter. gata 90-94 pyruvate kinase L/R Homo sapiens 168-172 8370527-5 1993 We find that TBP (TATA-binding protein) alone can activate transcription of beta-globin chromatin templates from promoters mutated to a canonical TATA box but is ineffective on those containing the normal -30 GATA site. gata 209-213 TATA-box binding protein Gallus gallus 18-38 1744088-4 1991 In all three mast cell lines, the promoter activity of the MC-CPA gene depended on the GATA binding site. gata 87-91 carboxypeptidase A3 Homo sapiens 59-65 1596565-13 1992 Inspection of the 5" flanking region of the TFPI gene showed a conserved GATA-binding motif located approximately 400 bp upstream of the proposed transcription initiation site(s). gata 73-77 tissue factor pathway inhibitor Homo sapiens 44-48 1583720-0 1992 Differential factor binding at the promoter of early baculovirus gene PE38 during viral infection: GATA motif is recognized by an insect protein. gata 99-103 hypothetical protein Autographa californica nucleopolyhedrovirus 70-74 1583720-2 1992 A GATA motif located 50 nucleotides upstream of the PE38 transcriptional start site is recognized differentially in the course of infection. gata 2-6 hypothetical protein Autographa californica nucleopolyhedrovirus 52-56 7678994-5 1993 In addition, our results indicate that the tal-1 1A promoter, which contains two consensus GATA-binding sites, is active mainly in these lineages. gata 91-95 TAL bHLH transcription factor 1, erythroid differentiation factor Homo sapiens 43-48 1396592-3 1992 We used gel shift and transfection assays to demonstrate that the GATA motif in the SCL promoter binds GATA-1 (and GATA-2), and also mediates transcriptional transactivation. gata 66-70 GATA binding protein 1 Homo sapiens 103-109 1396592-3 1992 We used gel shift and transfection assays to demonstrate that the GATA motif in the SCL promoter binds GATA-1 (and GATA-2), and also mediates transcriptional transactivation. gata 66-70 GATA binding protein 2 Homo sapiens 115-121 1590778-6 1992 Gel-mobility-shift assays with 23 bp oligonucleotides containing the GATA-binding site (AGATAA) of the histone H5 enhancer or of the beta-globin enhancer showed that the GATA sequence was sufficient for the formation of at least five complexes. gata 69-73 H1 histone family, member 0 Gallus gallus 103-113 1590778-6 1992 Gel-mobility-shift assays with 23 bp oligonucleotides containing the GATA-binding site (AGATAA) of the histone H5 enhancer or of the beta-globin enhancer showed that the GATA sequence was sufficient for the formation of at least five complexes. gata 89-93 H1 histone family, member 0 Gallus gallus 103-113 1918021-6 1991 A nuclear protein binding to the GATA motif in Region A has been identified and proven to be necessary for expression of the ET1 gene. gata 33-37 endothelin 1 Homo sapiens 125-128 1944279-8 1991 On the basis of the above-described results, we propose that the megakaryocyte-specific enhancer/silencer domain and the GATA site are responsible for high-level expression of the PF4 gene in a lineage-specific manner. gata 121-125 platelet factor 4 Rattus norvegicus 180-183 1766438-7 1991 Characteristic GATA repeats with a conserved spacing were found in 5" upstream sequences of cab 1A-D, cab 3A-C, cab 11 and cab 12. gata 15-19 chlorophyll a/b-binding protein Cab-1A Solanum lycopersicum 92-98 1766438-7 1991 Characteristic GATA repeats with a conserved spacing were found in 5" upstream sequences of cab 1A-D, cab 3A-C, cab 11 and cab 12. gata 15-19 chlorophyll a-b binding protein CAB11 Solanum lycopersicum 112-118 2044960-6 1991 Full promoter activity requires the presence of proximal CACCC box sequences and an upstream, double GATA motif that binds a single GATA-1 molecule in an asymmetric fashion. gata 101-105 GATA binding protein 1 Mus musculus 132-138 2388628-6 1990 Gel shift analysis, methylation interference, protein-DNA cross-linking, and oligonucleotide competition studies revealed that BAE cell nuclear extract contains a 47-kilodalton DNA-binding protein recognizing the core motif TATC (GATA) located at positions -135 to -132 of the PPET-1 promoter. gata 230-234 zinc finger protein 763 Homo sapiens 177-196 2388628-6 1990 Gel shift analysis, methylation interference, protein-DNA cross-linking, and oligonucleotide competition studies revealed that BAE cell nuclear extract contains a 47-kilodalton DNA-binding protein recognizing the core motif TATC (GATA) located at positions -135 to -132 of the PPET-1 promoter. gata 230-234 endothelin 1 Bos taurus 277-283 2388628-11 1990 We conclude that a nuclear factor with binding specificity for a GATA motif similar to that of the transcriptional activator GF-1 is necessary for the efficient and cell-specific expression of the human PPET-1 gene. gata 65-69 GATA binding protein 1 Homo sapiens 125-129 2388628-11 1990 We conclude that a nuclear factor with binding specificity for a GATA motif similar to that of the transcriptional activator GF-1 is necessary for the efficient and cell-specific expression of the human PPET-1 gene. gata 65-69 endothelin 1 Homo sapiens 203-209 1827068-5 1991 hGATA-3 contains a zinc finger domain that is highly related to the DNA-binding domain of the erythroid-specific transcription factor, GATA-1, and binds to a region of T alpha 3 that contains a consensus GATA binding site (AGATAG). gata 1-5 GATA binding protein 1 Homo sapiens 135-141 2276623-1 1990 The murine, erythroid DNA-binding protein GF-1 (also known as NF-E1, Eryf 1), a 413-amino acid polypeptide with two novel finger domains of the Cx-Cx variety, recognizes a consensus GATA motif present in cis elements of the majority of erythroid-expressed genes. gata 182-186 gonadal fat pad weight 1 Mus musculus 42-46 2276623-1 1990 The murine, erythroid DNA-binding protein GF-1 (also known as NF-E1, Eryf 1), a 413-amino acid polypeptide with two novel finger domains of the Cx-Cx variety, recognizes a consensus GATA motif present in cis elements of the majority of erythroid-expressed genes. gata 182-186 YY1 transcription factor Mus musculus 62-67 2276623-1 1990 The murine, erythroid DNA-binding protein GF-1 (also known as NF-E1, Eryf 1), a 413-amino acid polypeptide with two novel finger domains of the Cx-Cx variety, recognizes a consensus GATA motif present in cis elements of the majority of erythroid-expressed genes. gata 182-186 GATA binding protein 1 Mus musculus 69-75 2276623-3 1990 Using a cotransfection assay, we find that GF-1 is a potent transcriptional activator with several activation domains but that this is revealed only in heterologous cells and with reporters containing minimal promoters onto which either a single or multiple GATA-binding sites are placed. gata 258-262 gonadal fat pad weight 1 Mus musculus 43-47 2276623-6 1990 The role of each finger is more pronounced with some GATA-binding sites than with others, suggesting a diversity of interactions between GF-1 and different target sites. gata 53-57 gonadal fat pad weight 1 Mus musculus 137-141 34897794-5 2022 This study expands the spectrum of genetic defects associated with BDE2 and TRPS and demonstrates the pathogenicity of TRPS1 missense variants located outside both the nuclear localization signal and the GATA and Ikaros-like binding domains. gata 204-208 transcriptional repressor GATA binding 1 Homo sapiens 119-124