PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7834611-2	1995	Production of MTX from MTX-Phe, catalyzed by bovine pancreas carboxypeptidase A (CPA), was 250-fold faster than the corresponding reaction involving methotrexate-alpha-alanine, previously the best MTX peptide substrate for the enzyme.	methotrexate-alpha-alanine	149-175	carboxypeptidase A1	Homo sapiens	81-84
2719954-5	1989	Pancreatic carboxypeptidase A (CP-A) hydrolyzed MTX-Ala and, at a much slower rate, MTX-Asp and MTX-Arg.	methotrexate-alpha-alanine	48-55	carboxypeptidase A1, pancreatic	Mus musculus	31-35
1731945-0	1992	Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.	methotrexate-alpha-alanine	14-40	carboxypeptidase A1	Homo sapiens	44-62
1731945-8	1992	This potentiation of MTX-Ala cytotoxicity by conjugate-bound CP-A, which was at least 30-fold greater than that produced by a comparable amount of free enzyme, is attributed to enhanced effectiveness of MTX generated at the cell surface as opposed to the surrounding medium.	methotrexate-alpha-alanine	21-28	carboxypeptidase A1	Homo sapiens	61-65
1877392-5	1991	UCLA-P3 cells that had been exposed to the conjugate and then washed thoroughly were extremely sensitive to methotrexate alpha-alanine (MTX-Ala), a prodrug form of MTX.	methotrexate-alpha-alanine	108-134	metaxin 1	Homo sapiens	136-139
1877392-5	1991	UCLA-P3 cells that had been exposed to the conjugate and then washed thoroughly were extremely sensitive to methotrexate alpha-alanine (MTX-Ala), a prodrug form of MTX.	methotrexate-alpha-alanine	108-134	metaxin 1	Homo sapiens	164-167
34893236-5	2022	MTX-ALA NGs efficiently ameliorated the skin manifestations and down-regulated the proinflammatory cytokines of TNF-alpha and IL-17A in imiquimod-induced psoriatic mice (p < 0.001).	methotrexate-alpha-alanine	0-7	tumor necrosis factor	Mus musculus	112-121
34893236-5	2022	MTX-ALA NGs efficiently ameliorated the skin manifestations and down-regulated the proinflammatory cytokines of TNF-alpha and IL-17A in imiquimod-induced psoriatic mice (p < 0.001).	methotrexate-alpha-alanine	0-7	interleukin 17A	Mus musculus	126-132
2719954-9	1989	MTX-Ala was much less toxic than MTX (ID50 values of 2.0 X 10(-6) M and 2.4 x 10(-8) M, respectively), but in the presence of CP-A the ID50 of the peptide improved to 8.5 X 10(-8) M. Similar results were obtained with MTX-Asp/CP-A and MTX-Ala/CP-B combinations.	methotrexate-alpha-alanine	0-7	carboxypeptidase A1, pancreatic	Mus musculus	126-130
2719954-9	1989	MTX-Ala was much less toxic than MTX (ID50 values of 2.0 X 10(-6) M and 2.4 x 10(-8) M, respectively), but in the presence of CP-A the ID50 of the peptide improved to 8.5 X 10(-8) M. Similar results were obtained with MTX-Asp/CP-A and MTX-Ala/CP-B combinations.	methotrexate-alpha-alanine	0-7	carboxypeptidase A1, pancreatic	Mus musculus	226-230
24485831-6	2014	RESULTS: Pretreatment of SCC4 cells by 0.001 mg/L MTX for 72 hours resulted in a significant augmentation in MTX-ALA-PDT-induced killing of SCC4 cells (p &lt; 0.05).	methotrexate-alpha-alanine	109-116	MAU2 sister chromatid cohesion factor	Homo sapiens	25-29
3074629-6	1988	The MTX-ala and, to a lesser extent, MTX-arg were substrates for pancreatic carboxypeptidase B.	methotrexate-alpha-alanine	4-11	carboxypeptidase B1 (tissue)	Mus musculus	76-94
24485831-6	2014	RESULTS: Pretreatment of SCC4 cells by 0.001 mg/L MTX for 72 hours resulted in a significant augmentation in MTX-ALA-PDT-induced killing of SCC4 cells (p &lt; 0.05).	methotrexate-alpha-alanine	109-116	MAU2 sister chromatid cohesion factor	Homo sapiens	140-144