PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25767823-0	2014	The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRbeta MRNA expression in the eye of zebrafish embryos.	6-oh-bde	20-28	thyroid hormone receptor beta	Danio rerio	65-72
28031414-7	2017	Intracellular concentrations of known P-gp and BCRP substrates [(3H)-paclitaxel and (3H)-prazosin, respectively] were significantly higher (indicating less efflux) in NIH-3T3-MDR1 and MDCK-BCRP cells in the presence of 6-OH-BDE-47, but not BDE-47.	6-oh-bde	219-227	ATP binding cassette subfamily B member 1	Homo sapiens	38-42
28031414-7	2017	Intracellular concentrations of known P-gp and BCRP substrates [(3H)-paclitaxel and (3H)-prazosin, respectively] were significantly higher (indicating less efflux) in NIH-3T3-MDR1 and MDCK-BCRP cells in the presence of 6-OH-BDE-47, but not BDE-47.	6-oh-bde	219-227	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-51
25531265-5	2015	This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad).	6-oh-bde	27-35	cadherin 1	Homo sapiens	105-115
25531265-5	2015	This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad).	6-oh-bde	27-35	cadherin 1	Homo sapiens	117-122
25531265-5	2015	This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad).	6-oh-bde	27-35	vimentin	Homo sapiens	194-202
25531265-5	2015	This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad).	6-oh-bde	27-35	vimentin	Homo sapiens	204-207
25531265-5	2015	This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad).	6-oh-bde	27-35	cadherin 2	Homo sapiens	213-223
25531265-5	2015	This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad).	6-oh-bde	27-35	cadherin 2	Homo sapiens	225-230
25767823-6	2014	Interestingly, exposure to the native thyroid hormone, triiodothyronine (T3) also led to similar responses: decreased THRbeta mRNA expression, decreased melanin pigmentation and increased apoptosis, suggesting that 6-OH-BDE 47 may be acting as a T3 mimic.	6-oh-bde	215-223	thyroid hormone receptor beta	Danio rerio	118-125
25767823-8	2014	Knock down of THRbeta led to decreases in melanin pigmentation and increases in apoptotic cells in the eye of zebrafish embryos, similar to exposure to T3 and 6-OH-BDE 47, but THRbeta mRNA overexpression rescued these effects.	6-oh-bde	159-167	thyroid hormone receptor beta	Danio rerio	14-21
25767823-10	2014	This study suggests that 6-OH-BDE 47 disrupts the activity of THRbeta in early life stages of zebrafish, and warrants further studies on effects in developing humans.	6-oh-bde	25-33	thyroid hormone receptor beta	Danio rerio	62-69
21106467-7	2011	The hydroxylated BDEs 6-OH-BDE-47 and 4 -OH-BDE-49 are biphasic RyR modulators.	6-oh-bde	22-30	ryanodine receptor 1	Homo sapiens	64-67
18313098-6	2008	Exposure to 0.05 microM 2"-OH-BDE-68 significantly induced the expression of CYP11A, CYP11B2, CYP17, CYP21, 3betaHSD2, 17betaHSD1, and 17betaHSD4, and the expression of StAR was induced by 6-OH-BDE-90 at the three exposure concentrations.	6-oh-bde	189-197	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	77-83