PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21786685-1	2011	Effect of carcinogenic polycyclic aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and 3-methylcholanthrene (MC) on transcription factor NF-kappaB activation was studied.	benzo(a)	62-70	nuclear factor kappa B subunit 1	Homo sapiens	136-145
18675828-6	2008	Overall, UGT1A1-53 and -3156 genotypes modified the association between dietary benzo(a)pyrene (BaP) and colon cancer (P for interaction=0.02 and 0.03, respectively).	benzo(a)	80-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	9-15
17908424-0	2007	[c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts].	benzo(a)	113-121	mitogen-activated protein kinase 8	Homo sapiens	1-26
17908424-0	2007	[c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts].	benzo(a)	113-121	mitogen-activated protein kinase 1	Homo sapiens	31-76
17908424-0	2007	[c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts].	benzo(a)	113-121	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	1-6
16600107-0	2006	[ERK and JNK/AP-1 pathways involved in benzo(a)pyrene induced cell cycle changes in human embryo lung fibroblasts].	benzo(a)	39-47	mitogen-activated protein kinase 1	Homo sapiens	1-4
17220276-6	2007	Treatment of Hus1(neo/neo) and Hus1(neo/Delta1) cells with the DNA adducting agent benzo(a)pyrene dihydrodriol epoxide resulted in a loss of cell viability that was associated with S-phase DNA damage checkpoint failure.	benzo(a)	83-91	HUS1 checkpoint clamp component	Homo sapiens	13-17
17220276-6	2007	Treatment of Hus1(neo/neo) and Hus1(neo/Delta1) cells with the DNA adducting agent benzo(a)pyrene dihydrodriol epoxide resulted in a loss of cell viability that was associated with S-phase DNA damage checkpoint failure.	benzo(a)	83-91	HUS1 checkpoint clamp component	Homo sapiens	31-35
16600107-0	2006	[ERK and JNK/AP-1 pathways involved in benzo(a)pyrene induced cell cycle changes in human embryo lung fibroblasts].	benzo(a)	39-47	mitogen-activated protein kinase 8	Homo sapiens	9-12
7574713-7	1995	Introduction of an antisense 24-mer oligonucleotide to glycine N-methyltransferase cDNA into rat hepatoma H4IIE cells by lipofectin resulted in a 60% reduction in the benzo(a)pyrene-mediated induction of ethoxyresorufin-O-deethylase activity and protein over the sense and scrambled antisense oligonucleotide controls.	benzo(a)	167-175	glycine N-methyltransferase	Rattus norvegicus	55-82
14744740-8	2004	These data suggest that the UGT1A1 TATAA box polymorphism plays a role in an individual"s overall ability to detoxify benzo(a)pyrene and in cancer risk.	benzo(a)	118-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	28-34
12792991-1	2003	In order to investigate the relationship between proliferative activities and heat stress protein 70(HSP70) expression of porcine aortic endothelial cells(ECs) treated by benzo(a) pryene in vitro, porcine aortic endothelial cells were cultured in vitro, treated by different concentration of BaP(0, 0.5, 1, 10, 20 mumol/L) for 24 hours.	benzo(a)	171-179	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
9606968-12	1998	For example, mGSTA1, but not mGSTA2, subunit expression was observed in the skin, which is a target organ for benzo(a)pyrene (BP)-induced cancer in mice.	benzo(a)	110-118	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	13-19
27901495-5	2017	Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation.	benzo(a)	13-21	dickkopf WNT signaling pathway inhibitor 2	Mus musculus	36-40
1459043-0	1992	Relationship between activities of cytochrome P-450 monooxygenases in human placental microsomes and binding of benzo(a)pyrene metabolites to calf thymus DNA.	benzo(a)	112-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	35-51
34800719-0	2022	KIF11, a plus end-directed kinesin, as a key gene in benzo(a)pyrene-induced non-small cell lung cancer.	benzo(a)	53-61	kinesin family member 11	Homo sapiens	0-5
27901495-5	2017	Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation.	benzo(a)	13-21	engrailed 1	Mus musculus	45-48
27901495-5	2017	Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation.	benzo(a)	13-21	lysophosphatidic acid receptor 2	Mus musculus	79-84
27901495-5	2017	Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation.	benzo(a)	13-21	dickkopf WNT signaling pathway inhibitor 2	Mus musculus	202-206
27901495-5	2017	Furthermore, benzo(a)pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to down-regulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation.	benzo(a)	13-21	engrailed 1	Mus musculus	211-214