PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 14747372-7 2004 Substitution of Cl anion with gluconate in the external solution enhanced RST-dependent urate transport. gluconic acid 30-39 solute carrier family 22 member 12 Homo sapiens 74-77 15715267-12 2005 The heating of As(V) in the presence of gluconate, glucose, ascorbic acid, methionine, isoleucine, sodium chloride, and pure water, in autoclave for 15 minutes, showed that, whereas no As(III) was found in pure water and sodium chloride solution, approximately 50% of As(V) was converted into As(III) in the remainder of the solutions. gluconic acid 40-49 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 15-20 15850610-3 2005 On resuspension of BCECF-loaded platelets in a chloride-free medium (gluconate replaced) that contains bicarbonate, cytosolic pH (pHi) increased and stabilized after 10 min at an alkaline value. gluconic acid 69-78 glucose-6-phosphate isomerase Homo sapiens 130-133 15850610-8 2005 Posterior addition of NaCl after 5 min in high gluconate reproduced the pHi fall of the control experiment. gluconic acid 47-56 glucose-6-phosphate isomerase Homo sapiens 72-75 15156318-7 2004 Osmotic shock (exposure to 700 mOsm by addition of sucrose for 12 h), removal of Cl(-) (replaced by gluconate for 15 h) or removal of glucose (12 h) decreased cell volume and increased the number of annexin-binding erythrocytes. gluconic acid 100-109 annexin A11, opposite strand Mus musculus 199-206 15226459-7 2004 After administration of a zinc supplement (22 mg zinc gluconate/d for 27 d), ZIP1 expression decreased by 17% (P < 0.01) and 21% (P < 0.05) in the peripheral leukocytes collected from 15 young (20-25 y) and 10 elderly (64-75 y) subjects, respectively. gluconic acid 49-63 solute carrier family 39 member 1 Homo sapiens 77-81 15497133-0 2004 Gluconic acid production in bioreactor with immobilized glucose oxidase plus catalase on polymer membrane adjacent to anion-exchange membrane. gluconic acid 0-13 catalase Homo sapiens 77-85 15253640-4 2004 The GOx-catalyzed oxidation of glucose produces gluconic acid, inducing the pH-responsive polymer to shrink, which in turn decreases the polymer mass. gluconic acid 48-61 hydroxyacid oxidase 1 Homo sapiens 4-7 10973981-3 2000 Replacement of Cl(-) by gluconate or 2-(N-morpholino)ethanesulfonic acid decreased the apparent affinity of GAT1 and SGLT1 for Na(+) and the organic substrate. gluconic acid 24-33 solute carrier family 6 member 1 Homo sapiens 108-112 12761352-8 2003 Reversal potential measurements showed that the human P2X5 receptor was permeable to calcium (PCa/PNa = 1.5) and N-methyl-d-glucamine (NMDG) (PNMDG/PNa = 0.4); it was also permeable to chloride (PCl/PNa = 0.5) but not gluconate (Pgluc/PNa = 0.01) ions. gluconic acid 218-227 purinergic receptor P2X 5 Homo sapiens 54-58 11578909-2 2001 Gluconate has been used as exchange ligand in the carrier added experiments and in the syntheses of 99Tc-CCK(4) and Re-CCK(4) complexes to be able to reproduce at macroscopic level the same chemical reactions occurring at non carrier added conditions. gluconic acid 0-9 protein tyrosine kinase 7 (inactive) Homo sapiens 105-110 11578909-2 2001 Gluconate has been used as exchange ligand in the carrier added experiments and in the syntheses of 99Tc-CCK(4) and Re-CCK(4) complexes to be able to reproduce at macroscopic level the same chemical reactions occurring at non carrier added conditions. gluconic acid 0-9 protein tyrosine kinase 7 (inactive) Homo sapiens 119-124 12562898-3 2003 In normal, but not CF, epithelia, replacing mucosal Cl- with gluconate caused intracellular pH (pHi) to increase, and the initial rates (Delta pH min-1) of this increase were modestly augmented (approximately 26 %) when normal cells were pretreated with forskolin (10 microM). gluconic acid 61-70 glucose-6-phosphate isomerase Homo sapiens 96-99 10973981-3 2000 Replacement of Cl(-) by gluconate or 2-(N-morpholino)ethanesulfonic acid decreased the apparent affinity of GAT1 and SGLT1 for Na(+) and the organic substrate. gluconic acid 24-33 solute carrier family 5 member 1 Homo sapiens 117-122 10320738-2 1999 Potassium fluoride (KF), 440 mM trimethylamine chloride and exclusion of bovine serum albumin (BSA) decreased the activity of the enzyme, while ethylene glycol-bis (beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) and the potassium salts of aspartate, gluconate, methylsulfate and monobasic phosphate increased its activity. gluconic acid 260-269 albumin Homo sapiens 80-93 9691115-2 1998 The effect of the ions specifically depends on their chemical nature following the Hofmeister ion series for cations (Li+ < NH+4 < K- approximately Cs+ </= Na+) and anions (gluconate- < Cl- < NO3- approximately ClO4- approximately SCN-) respectively, indicating that both are involved in the formation of the salt-protein complex that can react with ryanodine. gluconic acid 182-191 NBL1, DAN family BMP antagonist Homo sapiens 207-210 10408615-5 1999 Gluconate also reduced N-methyl-D-aspartate-induced membrane currents recorded from CA1 neurons in a dose-dependent manner. gluconic acid 0-9 carbonic anhydrase 1 Rattus norvegicus 84-87 10408615-7 1999 Although gluconate chelated Ca2+ most strongly among the four Cl- substitutes examined, excitotoxic neuronal death could be protected by 7 mM gluconate without Ca2+ chelating action. gluconic acid 9-18 carbonic anhydrase 2 Rattus norvegicus 28-31 10408615-9 1999 Gluconate suppressed the N-methyl-D-aspartate component of excitatory synaptic currents evoked in CA1 neurons. gluconic acid 0-9 carbonic anhydrase 1 Rattus norvegicus 98-101 9841653-4 1998 The reason for this low yield was studied and shown not to be caused by enzyme inactivation or a pH drop during the reaction but due to an instability of the cofactor NADP+. Although gluconic acid inhibited both NADPH production and oxidation by GDH and hydrogenase, respectively, it was not the major cause of NADP+ instability. gluconic acid 184-197 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 247-250 9769420-7 1998 Many of the biophysical and pharmacological properties of the currents were phenotypically similar to those of the CFTR Cl- channel, such as the ohmic current-voltage relationship, the anion selectivity with a Type III sequence (Br- > Cl- > I- >> F- >= gluconate-), I--induced blockage, insensitivity to a stilbene-derivative Cl- channel blocker, and sensitivity to a carboxylate analogue Cl- channel blocker. gluconic acid 268-277 cystic fibrosis transmembrane conductance regulator Cavia porcellus 115-119 9688606-3 1998 However, replacement of external Cl- with gluconate caused an H2DIDS-inhibitable (100 microM) increase in the pHi of HCMV-infected cells but not in mock-infected cells. gluconic acid 42-51 glucose-6-phosphate isomerase Homo sapiens 110-113 9379169-1 1997 The mechanism of Cl ion permeation through single cystic fibrosis transmembrane conductance regulator (CFTR) channels was studied using the channel-blocking ion gluconate. gluconic acid 161-170 CF transmembrane conductance regulator Homo sapiens 50-101 9671976-6 1998 Replacing Na by other cations or Cl by gluconate increased k to 0.22 min(-1) and 0.26 min(-1), respectively, and 86Rb efflux by 4-23% and 39, respectively. gluconic acid 39-48 CD59 molecule (CD59 blood group) Homo sapiens 69-75 9671976-6 1998 Replacing Na by other cations or Cl by gluconate increased k to 0.22 min(-1) and 0.26 min(-1), respectively, and 86Rb efflux by 4-23% and 39, respectively. gluconic acid 39-48 CD59 molecule (CD59 blood group) Homo sapiens 86-92 9512497-6 1998 Whole-cell membrane currents recorded in TrpC1-expressing cells increased as a function of post-infection time and were (1) inwardly rectifying in symmetrical sodium gluconate solutions, (2) non-selective with respect to Na+, Ca2+ and Ba2+, and (3) blocked by La3+. gluconic acid 159-175 transient receptor potential cation channel subfamily C member 1 Homo sapiens 41-46 10806782-3 1998 After treatment with zinc gluconate for 1 month the serum zinc level, RBC-C3b RR, RBC-ICR, CD3 and CD4/CD8 became normal, CD8 also approached to normal. gluconic acid 21-35 CD4 molecule Homo sapiens 99-102 10806782-3 1998 After treatment with zinc gluconate for 1 month the serum zinc level, RBC-C3b RR, RBC-ICR, CD3 and CD4/CD8 became normal, CD8 also approached to normal. gluconic acid 21-35 CD8a molecule Homo sapiens 103-106 10806782-3 1998 After treatment with zinc gluconate for 1 month the serum zinc level, RBC-C3b RR, RBC-ICR, CD3 and CD4/CD8 became normal, CD8 also approached to normal. gluconic acid 21-35 CD8a molecule Homo sapiens 122-125 9518736-9 1998 The ability of CFTR to inhibit ENaC currents was significantly reduced either when extracellular Cl- was replaced by poorly conductive anions, e.g. SCN- or gluconate, or when CFTR was inhibited by diphenylamine-carboxylate (DPC, 1 mmol l-1). gluconic acid 156-165 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 15-19 10099229-4 1998 Continuous reactor performance in the presence of PEI and BSA showed that NAD(H), glucose dehydrogenase, and lactate dehydrogenase were retained by 10-kDa ultrafiltration membranes; L-lactate and gluconate were produced at conversions higher than 95%. gluconic acid 196-205 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 82-103 9379169-1 1997 The mechanism of Cl ion permeation through single cystic fibrosis transmembrane conductance regulator (CFTR) channels was studied using the channel-blocking ion gluconate. gluconic acid 161-170 CF transmembrane conductance regulator Homo sapiens 103-107 9379169-2 1997 High concentrations of intracellular gluconate ions cause a rapid, voltage-dependent block of CFTR Cl channels by binding to a site approximately 40% of the way through the transmembrane electric field. gluconic acid 37-46 CF transmembrane conductance regulator Homo sapiens 94-98 9379169-7 1997 Based on this evidence that CFTR is a multi-ion pore, we have analyzed Cl permeation and gluconate block using discrete-state models with multiple occupancy. gluconic acid 89-98 CF transmembrane conductance regulator Homo sapiens 28-32 9642379-1 1997 OBJECTIVE: To study the effects of oral low-dose magnesium gluconate in prevention of pregnancy induced hypertension (PIH) and its mechanism. gluconic acid 49-68 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 118-121 9642379-4 1997 RESULTS: 4% of the pregnant women developed PIH after magnesium gluconate treatment, which was substantially lower than that in the control group (16%) (P < 0.05). gluconic acid 54-73 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 44-47 9642379-9 1997 CONCLUSION: Low-dose magnesium gluconate may efficiently prevent PIH in high risk women. gluconic acid 21-40 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 65-68 9194712-11 1997 These results, combined with the fact that both the cAMP and the CRP levels are lowered by glucose 6-phosphate, lactose and gluconate, lead to the conclusion that the decreased cAMP and CRP levels are the cause of catabolite repression by these non-PTS carbon sources. gluconic acid 124-133 catabolite gene activator protein Escherichia coli 65-68 9276756-8 1997 Replacing extracellular Cl- by other permeant anions shifted the inactivation curve in parallel with their relative permeabilities (SCN- > I- > NO3- > Cl- >> gluconate). gluconic acid 173-182 NBL1, DAN family BMP antagonist Homo sapiens 150-153 9194712-11 1997 These results, combined with the fact that both the cAMP and the CRP levels are lowered by glucose 6-phosphate, lactose and gluconate, lead to the conclusion that the decreased cAMP and CRP levels are the cause of catabolite repression by these non-PTS carbon sources. gluconic acid 124-133 catabolite gene activator protein Escherichia coli 186-189 9013613-3 1997 Indeed, both the pICln and the ClC-6 induced current are outwardly rectifying, they inactivate slowly at positive potentials and have an anion permeability sequence NO3- > I- > Br- > Cl- > gluconate. gluconic acid 201-210 chloride nucleotide-sensitive channel 1A Homo sapiens 17-22 9013613-3 1997 Indeed, both the pICln and the ClC-6 induced current are outwardly rectifying, they inactivate slowly at positive potentials and have an anion permeability sequence NO3- > I- > Br- > Cl- > gluconate. gluconic acid 201-210 chloride voltage-gated channel 6 Homo sapiens 31-36 9013613-3 1997 Indeed, both the pICln and the ClC-6 induced current are outwardly rectifying, they inactivate slowly at positive potentials and have an anion permeability sequence NO3- > I- > Br- > Cl- > gluconate. gluconic acid 201-210 NBL1, DAN family BMP antagonist S homeolog Xenopus laevis 165-168 8917766-6 1996 (3) Substitution of external Cl- by gluconate (95 mM) caused a rapid pHi rise both in normal Na+ and low-Na+ perfusion. gluconic acid 36-45 glucose-6-phosphate isomerase Homo sapiens 69-72 8944640-4 1996 In Cl(-)-depleted medium (gluconate as a substitute), cAMP stimulation evoked a K+ current in CFTR-transfected but not in untransfected CFPAC-1 cells. gluconic acid 26-35 cathelicidin antimicrobial peptide Homo sapiens 54-58 8944640-4 1996 In Cl(-)-depleted medium (gluconate as a substitute), cAMP stimulation evoked a K+ current in CFTR-transfected but not in untransfected CFPAC-1 cells. gluconic acid 26-35 CF transmembrane conductance regulator Homo sapiens 94-98 7900846-4 1995 Na-HCO3 cotransporter activity was measured in highly purified rabbit renal cortical basolateral membranes (BLMV) as the difference in 22Na uptake in presence of HCO3- and gluconate. gluconic acid 172-181 electrogenic sodium bicarbonate cotransporter 1 Oryctolagus cuniculus 0-21 8770004-3 1996 Using a single-channel recording from Chinese hamster ovary cells stably expressing CFTR, we have found that both the sparingly permeant anion glutamate and the impermeant anion gluconate cause a rapid, voltage-dependent block of CFTR channels when applied to the intracellular, but not the extracellular, face of excised patches. gluconic acid 178-187 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 84-88 8770004-3 1996 Using a single-channel recording from Chinese hamster ovary cells stably expressing CFTR, we have found that both the sparingly permeant anion glutamate and the impermeant anion gluconate cause a rapid, voltage-dependent block of CFTR channels when applied to the intracellular, but not the extracellular, face of excised patches. gluconic acid 178-187 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 230-234 8753075-5 1996 Ion selectivity of this mechanism was K+ = Rb+ > Cs+ > Na+ = NMDG+ (N-methyl-D-glucamine) for cations and Cl- = SCN- = NO3- > > gluconate- for anions. gluconic acid 140-149 NBL1, DAN family BMP antagonist Homo sapiens 125-128 8821823-4 1996 Na-HCO3 cotransporter activity (expressed in nmol/mg protein/3 seconds) was taken as the difference in 22Na uptake in the presence of HCO3 and gluconate. gluconic acid 143-152 electrogenic sodium bicarbonate cotransporter 1 Oryctolagus cuniculus 0-21 8589287-4 1995 Na-HCO3 cotransporter activity (expressed in nanomoles per milligram of protein per 3 s) was taken as the difference in 22Na uptake in the presence of HCO3 and gluconate. gluconic acid 160-169 electrogenic sodium bicarbonate cotransporter 1 Oryctolagus cuniculus 0-21 7752540-3 1994 The conductive pathway for anions is inhibited by 9-AC and has the permeability sequence SCN > I > NO3 > Br > Cl > F > gluconate; it is also permeant to HCO3-. gluconic acid 137-146 NBL1, DAN family BMP antagonist Homo sapiens 105-108 7535636-5 1995 cAMP activation, anion selectivity (Cl- > I- > gluconate), and a dependence upon metabolic energy (metabolic poisoning inhibited GCl), all indicate that the GCl expressed in RD2(NL) is in fact CFTR-GCl. gluconic acid 53-62 germ cell-less 2, spermatogenesis associated Homo sapiens 163-166 7535636-5 1995 cAMP activation, anion selectivity (Cl- > I- > gluconate), and a dependence upon metabolic energy (metabolic poisoning inhibited GCl), all indicate that the GCl expressed in RD2(NL) is in fact CFTR-GCl. gluconic acid 53-62 germ cell-less 2, spermatogenesis associated Homo sapiens 163-166 7529236-3 1995 We report that addition of vasopressin to fura-2-loaded glomerular mesangial cells in culture markedly accelerated the rate at which Mn2+ quenched fura-2 fluorescence at its Ca(2+)-insensitive wavelength in the presence of extracellular NaCl, but that this quench response was attenuated when Cl- was removed from the extracellular medium by equimolar substitution with impermeant anions (gluconate, methanesulfonate, acetate, lactate). gluconic acid 389-398 arginine vasopressin Homo sapiens 27-38 7865219-6 1995 Substitution of gluconate for Cl- in the basolateral fluid, but not the apical fluid, resulted in a rise in steady-state pHi that was reversible on replacement of the basolateral fluid with Cl(-)-containing buffer, which occurred in HCO3(-)- but not Hepes-buffered medium. gluconic acid 16-25 glucose-6-phosphate isomerase Rattus norvegicus 121-124 8011858-7 1994 In addition, gluconic acids were chemically attached to insulin molecules. gluconic acid 13-27 insulin Homo sapiens 56-63 8011858-8 1994 The modified insulin, containing two gluconic acid units per insulin molecule, was isolated using ion-exchange chromatography. gluconic acid 37-50 insulin Homo sapiens 13-20 8011858-9 1994 This gluconic acid-modified insulin (G-Ins) was bound onto a PBA gel column, and the G-Ins release profile in response to varying glucose concentrations was investigated. gluconic acid 5-18 insulin Homo sapiens 28-35 8272366-5 1993 The conductance sequence of the channel as deduced from outward currents carried by five different anions including chloride was: Cl- > BR- > NO3- > gluconate > I-. gluconic acid 158-167 NBL1, DAN family BMP antagonist Homo sapiens 148-151 8272366-6 1993 The permeability sequence deduced from the reversal potentials was NO3- > or = Br- > Cl- > I- > gluconate. gluconic acid 108-117 NBL1, DAN family BMP antagonist Homo sapiens 67-70 1651666-5 1991 Ionic substitution of Cl with nontransported anions, iodide and gluconate, reduced ET-1-induced changes in Isc. gluconic acid 64-73 endothelin 1 Canis lupus familiaris 83-87 7687269-6 1993 The channels are anion selective with a permeability sequence of I- > SCN- > NO3-, Br- > Cl- > MeSO3- > acetate, propionate > ascorbate > aspartate and gluconate. gluconic acid 173-182 NBL1, DAN family BMP antagonist Homo sapiens 83-86 1281885-11 1992 cAMP activated basolateral GCl as indicated by increased bi-ionic (gluconate:Cl-, bath:lumen) diffusion potentials (by about 12 mV). gluconic acid 67-76 germ cell-less 2, spermatogenesis associated Homo sapiens 27-30 1517828-16 1992 When the recording pipettes contained KCl (140 mM), the resting potential of P3-4 neurons was 34 mV depolarized compared with resting potentials observed with potassium gluconate-filled pipettes. gluconic acid 159-178 alpha- and gamma-adaptin binding protein Rattus norvegicus 77-81 1372482-7 1992 In contrast, the cAMP-stimulated currents of CFTR-expressing oocytes were DIDS insensitive and were inhibited only approximately 50% when bath Cl was replaced by gluconate or glutamate. gluconic acid 162-171 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 45-49 1666052-9 1991 Use of cyclamate or gluconate in place of Cl- also resulted in the inhibition of basal and forskolin-stimulated ACTH secretion. gluconic acid 20-29 pro-opiomelanocortin-alpha Mus musculus 112-116 1332155-8 1992 Ionic substitution of Cl- with nontransported anions, iodide and gluconate, inhibited endothelin-1-induced increases in PD and SCC. gluconic acid 65-74 endothelin 1 Canis lupus familiaris 86-98 18595064-4 1990 A multienzyme system composed of NADPH-dependent aldose reductase (AR) and glucose dehydrogenase (GDH) was used for the production of sorbitol and gluconic acid from glucose and for the conjugated enzymatic regeneration of NADP(H). gluconic acid 147-160 2,4-dienoyl-CoA reductase 1 Homo sapiens 33-38 1645273-6 1991 Replacement of Cl- by gluconate elicited a rapid, 0.6-U increase in pHi. gluconic acid 22-31 glucose-6-phosphate isomerase Oryctolagus cuniculus 68-71 2127311-2 1990 Cell pH (pHi) was measured in response to sudden substitution of bath Cl- by gluconate. gluconic acid 77-86 glucose-6-phosphate isomerase Oryctolagus cuniculus 9-12 18595064-4 1990 A multienzyme system composed of NADPH-dependent aldose reductase (AR) and glucose dehydrogenase (GDH) was used for the production of sorbitol and gluconic acid from glucose and for the conjugated enzymatic regeneration of NADP(H). gluconic acid 147-160 aldo-keto reductase family 1 member B Homo sapiens 49-65 18595064-4 1990 A multienzyme system composed of NADPH-dependent aldose reductase (AR) and glucose dehydrogenase (GDH) was used for the production of sorbitol and gluconic acid from glucose and for the conjugated enzymatic regeneration of NADP(H). gluconic acid 147-160 aldo-keto reductase family 1 member B Homo sapiens 67-69 18595064-4 1990 A multienzyme system composed of NADPH-dependent aldose reductase (AR) and glucose dehydrogenase (GDH) was used for the production of sorbitol and gluconic acid from glucose and for the conjugated enzymatic regeneration of NADP(H). gluconic acid 147-160 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 75-96 18595064-4 1990 A multienzyme system composed of NADPH-dependent aldose reductase (AR) and glucose dehydrogenase (GDH) was used for the production of sorbitol and gluconic acid from glucose and for the conjugated enzymatic regeneration of NADP(H). gluconic acid 147-160 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 98-101 18592598-4 1990 On the example of the gluconic acid production catalyzed by glucose dehydrogenase, current as high as 0.1 A was obtained in experience where enzymatic activity was the main limitation. gluconic acid 22-35 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 60-81 34385012-4 2021 A cascaded catalytic reaction is triggered by glucose, in which GOx catalyzes the oxidation of glucose into gluconic acid and hydrogen peroxide (H2O2), and hydroxyl radical ( OH) is further produced with the catalysis of GQDs nanozyme with peroxidase-like activity, resulting in the degradation of AgNPs@GQDs-GOx with the release of Ag+. gluconic acid 108-121 hydroxyacid oxidase 1 Homo sapiens 64-67 34662447-6 2022 RESULTS: The Pten-KO prostate increased purine nucleotide pools, cystathionine, and both reduced and oxidized glutathione (GSH, GSSG), and gluconate/glucuronate species in addition to cholesteryl sulfate and polyamine precursor ornithine. gluconic acid 139-148 phosphatase and tensin homolog Mus musculus 13-17 33034314-5 2020 Once MONs-GOx@MnO2-Ce6 enter tumor cells, it catalyzes the oxidation of glucose using oxygen (O2) and generates hydrogen peroxide (H2O2) and gluconic acid, the former of which may accelerate the decomposition of MnO2 nanosheets. gluconic acid 141-154 hydroxyacid oxidase 1 Homo sapiens 10-13 34385012-4 2021 A cascaded catalytic reaction is triggered by glucose, in which GOx catalyzes the oxidation of glucose into gluconic acid and hydrogen peroxide (H2O2), and hydroxyl radical ( OH) is further produced with the catalysis of GQDs nanozyme with peroxidase-like activity, resulting in the degradation of AgNPs@GQDs-GOx with the release of Ag+. gluconic acid 108-121 hydroxyacid oxidase 1 Homo sapiens 309-312 34702529-0 2021 Chitosan-poloxamer-based thermosensitive hydrogels containing zinc gluconate/recombinant human epidermal growth factor benefit for antibacterial and wound healing. gluconic acid 62-76 epidermal growth factor Homo sapiens 95-118 34704735-7 2021 The GOx could oxidize the intratumoral glucose to produce gluconic acid and H2O2. gluconic acid 58-71 hydroxyacid oxidase 1 Homo sapiens 4-7 34649197-5 2021 Here GOx could catalyze the oxidation of glucose into gluconic acid and H2O2, thus depleting the glucose in tumor intracellular compartment while accelerating the release of the entrapped therapeutic payloads. gluconic acid 54-67 hydroxyacid oxidase 1 Homo sapiens 5-8 34391834-5 2021 In hyperglycemia, the encapsulated glucose-sensing enzyme GOx converts glucose to gluconic acid and lowers the pH of the microenvironment, causing insulin to adopt a positive charge. gluconic acid 82-95 hydroxyacid oxidase 1, liver Mus musculus 58-61 34585187-6 2021 The generated O2 was utilized by GOx in starvation therapy to consume glucose and produce H2O2 and gluconic acid. gluconic acid 99-112 hydroxyacid oxidase 1 Homo sapiens 33-36 34318860-7 2021 Glucose oxidase (GOx) elevated the gluconic acid ROS levels in tumor cells, resulting in an acidic and oxidative environment. gluconic acid 35-48 hydroxyacid oxidase 1 Homo sapiens 0-15 34423981-5 2021 According to the pH change produced by gluconic acid, the pH-sensitive monomer DEAEMA endowed the polymersome membrane with multilevelly tunable and self-regulative permeability, further controlling the release behavior of insulin. gluconic acid 39-52 insulin Homo sapiens 223-230 34215059-4 2021 Using the pH-responsive luminescence behavior of ZGOMP, we developed an autofluorescence-free biosensor using ZGOMP as a probe and gluconic acid as a quencher to detect prostate-specific antigen (PSA). gluconic acid 131-144 kallikrein related peptidase 3 Homo sapiens 169-194 34215059-4 2021 Using the pH-responsive luminescence behavior of ZGOMP, we developed an autofluorescence-free biosensor using ZGOMP as a probe and gluconic acid as a quencher to detect prostate-specific antigen (PSA). gluconic acid 131-144 kallikrein related peptidase 3 Homo sapiens 196-199 34572575-2 2021 Glucose oxidase (GOx), which is considered as an attractive starvation reagent for cancer therapy, can effectively catalyze the conversion of glucose into gluconic acid and hydrogen peroxide (H2O2) in the presence of O2. gluconic acid 155-168 hydroxyacid oxidase 1 Homo sapiens 0-15 34572575-2 2021 Glucose oxidase (GOx), which is considered as an attractive starvation reagent for cancer therapy, can effectively catalyze the conversion of glucose into gluconic acid and hydrogen peroxide (H2O2) in the presence of O2. gluconic acid 155-168 hydroxyacid oxidase 1 Homo sapiens 17-20 34318860-7 2021 Glucose oxidase (GOx) elevated the gluconic acid ROS levels in tumor cells, resulting in an acidic and oxidative environment. gluconic acid 35-48 hydroxyacid oxidase 1 Homo sapiens 17-20 34429071-6 2021 TMC4 allowed permeation of organic anions including gluconate, but their current amplitudes at positive potentials were less than that of Cl-. gluconic acid 52-61 transmembrane channel like 4 Homo sapiens 0-4 35293041-3 2022 This copper-mediated ketonization system was applicable for the synthesis of not only gluconic acid-derived ketone 6 as a synthetic intermediate in the transformation to canagliflozin, an SGLT2 inhibitor, but also thiolactol 8 , a valuable synthetic intermediate for (+)-biotin. gluconic acid 86-99 solute carrier family 5 member 2 Homo sapiens 188-193 34169349-6 2021 In the presence of glucose, GOx could catalyze glucose to produce H2O2 and gluconic acid. gluconic acid 75-88 hydroxyacid oxidase 1 Homo sapiens 28-31 34132713-5 2021 Accompanying the formed immunocomplexes, labeled GOx molecules catalyzed glucose into gluconic acid and hydrogen peroxide. gluconic acid 86-99 hydroxyacid oxidase 1 Homo sapiens 49-52 35348331-5 2022 GOx could effectively consume oxygen and catalyzed glucose into gluconic acid and hydrogen peroxide. gluconic acid 64-77 hydroxyacid oxidase 1 Homo sapiens 0-3 35352076-3 2022 After the introduction of glucose, GNPs@MIL-53 displays excellent glucose oxidase (GOx)-like activity to induce the conversion of glucose to gluconic acid and H2O2. gluconic acid 141-154 hydroxyacid oxidase 1 Homo sapiens 66-81 35352076-3 2022 After the introduction of glucose, GNPs@MIL-53 displays excellent glucose oxidase (GOx)-like activity to induce the conversion of glucose to gluconic acid and H2O2. gluconic acid 141-154 hydroxyacid oxidase 1 Homo sapiens 83-86 2594939-3 1989 However, replacing extracellular chloride with gluconate, such that the final bath chloride concentration was less than 20 mM, caused a marked alkalinization of pHi to a new steady-state value. gluconic acid 47-56 glucose-6-phosphate isomerase Rattus norvegicus 161-164 3037913-9 1987 It was also found that changing from NMG gluconate to Na gluconate Ringer caused pHi to increase from 7.1 to 7.3, and this alkalinization was blocked by 10(-3) M amiloride; changing from NMG gluconate to NMG Cl Ringer caused pHi to decrease to 6.7. gluconic acid 41-50 glucose-6-phosphate isomerase Oryctolagus cuniculus 81-84 3358935-2 1988 In this sequence, hexokinase is inhibited by its product glucose 6-phosphate and also by D-gluconic acid produced from the parallel enzymic reaction of glucose oxidase. gluconic acid 89-104 hexokinase 1 Homo sapiens 18-28 2450891-4 1988 Total peritubular chloride replacement with gluconate increased pHi by 0.8, and this change was inhibited by a pretreatment with an anion transport inhibitor, SITS. gluconic acid 44-53 glucose-6-phosphate isomerase Oryctolagus cuniculus 64-67 2474434-11 1989 Exchange of incubation medium chloride for gluconate or a reduction in the osmotic strength of the medium reduced both basal and secretagogue-stimulated ACTH secretion. gluconic acid 43-52 pro-opiomelanocortin-alpha Mus musculus 153-157 3255805-9 1988 As indicated by ion replacement studies (gluconate for Cl-), the apical membrane of normal cells exhibits an apical membrane Cl- conductance (GCl) that can be activated by isoprenaline. gluconic acid 41-50 germ cell-less 2, spermatogenesis associated Homo sapiens 142-145 3037913-9 1987 It was also found that changing from NMG gluconate to Na gluconate Ringer caused pHi to increase from 7.1 to 7.3, and this alkalinization was blocked by 10(-3) M amiloride; changing from NMG gluconate to NMG Cl Ringer caused pHi to decrease to 6.7. gluconic acid 41-50 glucose-6-phosphate isomerase Oryctolagus cuniculus 225-228 2442220-2 1987 Gluconate replacement increased pHi from 7.12 +/- 0.02 to 7.27 +/- 0.04, caused secretory rate to fall by 75%, and increased salivary HCO3 from 14 +/- 0.9 mmol/L to 67 +/- 1.5 mmol/L. gluconic acid 0-9 glucose-6-phosphate isomerase Rattus norvegicus 32-35 3030871-8 1987 In potassium gluconate Ringer"s, pHi was completely independent of pHo. gluconic acid 3-22 glucose-6-phosphate isomerase Oryctolagus cuniculus 33-36 3607269-3 1987 After rapid intravenous infusion (60 sec) of 4 mg/kg/lean body mass of calcium (as gluconate), CT concentration increased measurably (p less than 0.0001) in the controls, while remaining unchanged in the spasmophilic. gluconic acid 83-92 calcitonin related polypeptide alpha Homo sapiens 95-97 2436139-4 1987 After replacement of perfusate Cl with gluconate, the standard ACh concentration caused a rise in pHi to 7.50 +/- 0.02 followed by a fall to 7.27 +/- 0.04 after 60 min, concomitant with a 76% fall in secretory rate and a rise in salivary HCO3 concentration from 14 +/- 0.9 to 67 +/- 1.5 mmol/l. gluconic acid 39-48 glucose-6-phosphate isomerase Rattus norvegicus 98-101 3490793-6 1986 Replacement of external Cl- by gluconate reversibly increased pHc by 0.34 +/- 0.05 U. gluconic acid 31-40 solute carrier family 25 member 3 Homo sapiens 62-65 7193-2 1976 The final enzyme yield was increased by starch, maltose, glycerol, peptone, and yeast extract but reduced by acetate and gluconate, alpha-Glucosidase was formed in the cytoplasm and accumulated as a large pool during the logarithmic growth phase. gluconic acid 121-130 alpha-glucosidase Parageobacillus thermoglucosidasius 132-149 3495300-5 1986 Zinc gluconate in short courses appear to act as a regulator of CD8 lymphoid cells subsets. gluconic acid 0-14 CD8a molecule Homo sapiens 64-67 3755365-8 1986 Replacement of chloride with gluconate on both sides of the tissue significantly reduced the change in short circuit current produced by neuropeptide Y (1 X 10(-7) M), as did a similar replacement of bicarbonate. gluconic acid 29-38 neuropeptide Y Oryctolagus cuniculus 137-151 7430956-2 1980 The method uses glucose-dehydrogenase which converts glucose to gluconic acid. gluconic acid 64-77 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 16-37 33987139-2 2021 The current randomized controlled trial was carried out to evaluate the effect of zinc gluconate supplementation on migraine-related symptoms, serum level of high sensitivity C-reactive protein (hs-CRP) and lipid profile in migraineurs. gluconic acid 82-96 C-reactive protein Homo sapiens 175-193 33881052-3 2021 GOx on the surface of hollow mesoporous silica nanoparticles can catalyze the decomposition of intratumoral glucose to generate gluconic acid and H2O2, while Fe3O4 nanoparticles as a Fenton reaction catalyst can in situ catalyze H2O2 to produce highly toxic hydroxyl radicals ( OH). gluconic acid 128-141 hydroxyacid oxidase 1 Homo sapiens 0-3 33237737-4 2020 In response to the inherent acidity and H2O2 at the tumor sites, Ag2S-GOx@BHS would accelerate the structural degradation while releasing glucose oxidase (GOx), which could efficiently deplete intratumoral glucose to copious amounts of gluconic acid and H2O2. gluconic acid 236-249 angiotensin II receptor type 1 Homo sapiens 65-69 33383100-1 2021 OBJECTIVES: To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion. gluconic acid 50-59 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 88-92 33383100-3 2021 Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. gluconic acid 85-94 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 104-108 33464244-3 2021 GOx could catalyze the oxidation of intracellular glucose to gluconic acid and poisonous H2O2 to cause the deterioration of the tumor survival microenvironment, simultaneously achieving starvation and oxidation therapy. gluconic acid 61-74 hydroxyacid oxidase 1 Homo sapiens 0-3 33373089-5 2021 Within the dynamic pH-stable skeleton of the protein hydrogels, polymersomes with loaded PEGylated insulin biomacromolecules demonstrate a pH-responsive reversible swelling-deswelling and a desirable, on-demand cargo release which is induced by the enzymatic oxidation of glucose to gluconic acid. gluconic acid 283-296 insulin Homo sapiens 99-106 33237737-4 2020 In response to the inherent acidity and H2O2 at the tumor sites, Ag2S-GOx@BHS would accelerate the structural degradation while releasing glucose oxidase (GOx), which could efficiently deplete intratumoral glucose to copious amounts of gluconic acid and H2O2. gluconic acid 236-249 hydroxyacid oxidase 1 Homo sapiens 70-73 33237737-4 2020 In response to the inherent acidity and H2O2 at the tumor sites, Ag2S-GOx@BHS would accelerate the structural degradation while releasing glucose oxidase (GOx), which could efficiently deplete intratumoral glucose to copious amounts of gluconic acid and H2O2. gluconic acid 236-249 hydroxyacid oxidase 1 Homo sapiens 138-153 33237737-4 2020 In response to the inherent acidity and H2O2 at the tumor sites, Ag2S-GOx@BHS would accelerate the structural degradation while releasing glucose oxidase (GOx), which could efficiently deplete intratumoral glucose to copious amounts of gluconic acid and H2O2. gluconic acid 236-249 hydroxyacid oxidase 1 Homo sapiens 155-158 33237737-5 2020 More importantly, the sufficient H2O2 not only acts as a reactant to generate Ag+ from Ag2S for metal-ion therapy and improves the oxidative stress but also combines with gluconic acid results in the self-accelerating degradation process. gluconic acid 171-184 angiotensin II receptor type 1 Homo sapiens 87-91 33231593-5 2020 Initiated by the breakdown of glucose into gluconic acid and H2O2 by GOx, Fe-PDAP promotes reoxygenation by catalyzing the reaction-supplied and tumor cell-supplied H2O2 into O2, which then enhances the O2-dependent PDT. gluconic acid 43-56 hydroxyacid oxidase 1 Homo sapiens 69-72 32901482-5 2020 As observed, in a biomimetic cascade catalysis, the confined GOx in the microreactors are able to catalyze oxidation of glucose to gluconic acid and hydrogen peroxide (H2O2) followed by activation of Fe3O4-PEI by H2O2 for the oxidation of chromogenic substrate o-phenylenediamine (oPD) to 2, 3-diaminophenazine (DAP). gluconic acid 131-144 hydroxyacid oxidase 1 Homo sapiens 61-64 32820048-8 2020 In contrast, changes in selectivity made gluconate permeant in L46P EAAT2, and non-stationary noise analysis revealed slightly increased unitary current amplitudes in mutant EAAT2 anion channels. gluconic acid 41-50 solute carrier family 1 member 2 Homo sapiens 68-73 32820048-8 2020 In contrast, changes in selectivity made gluconate permeant in L46P EAAT2, and non-stationary noise analysis revealed slightly increased unitary current amplitudes in mutant EAAT2 anion channels. gluconic acid 41-50 solute carrier family 1 member 2 Homo sapiens 174-179 32278244-4 2020 The highest yields of GOS production with the lowest glucose concentration and highest GA production were obtained with lactose solution in multienzymatic systems in the presence of ultrasound (30% amplitude) when Gox was added after 1 h of treatment with beta-gal. gluconic acid 87-89 hydroxyacid oxidase 1 Homo sapiens 214-217 32278244-2 2020 In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey). gluconic acid 107-120 hydroxyacid oxidase 1 Homo sapiens 67-82 32353784-3 2020 The results of the hydrogen evolution curves and chemical kinetics of 7 different concentrations of sodium D-gluconate showed that when the sodium D-gluconate concentration reached 0.25 g L-1, there was almost no hydrogen generation, and the rate constant was almost zero. gluconic acid 100-118 L1 cell adhesion molecule Homo sapiens 188-191 32353784-3 2020 The results of the hydrogen evolution curves and chemical kinetics of 7 different concentrations of sodium D-gluconate showed that when the sodium D-gluconate concentration reached 0.25 g L-1, there was almost no hydrogen generation, and the rate constant was almost zero. gluconic acid 140-158 L1 cell adhesion molecule Homo sapiens 188-191 32278244-2 2020 In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey). gluconic acid 107-120 hydroxyacid oxidase 1 Homo sapiens 84-87 32536169-4 2020 In addition, by changing the pH dynamically using glucose oxidase (GOx)-catalyzed oxidation of glucose to gluconic acid, the direction of fluid pumping can be altered in situ, allowing for the design of a glucose sensor. gluconic acid 106-119 hydroxyacid oxidase 1 Homo sapiens 50-65 32278244-2 2020 In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey). gluconic acid 122-124 hydroxyacid oxidase 1 Homo sapiens 67-82 32278244-2 2020 In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey). gluconic acid 122-124 hydroxyacid oxidase 1 Homo sapiens 84-87 32278244-2 2020 In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey). gluconic acid 218-231 galactosidase beta 1 Homo sapiens 261-279 32278244-2 2020 In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey). gluconic acid 218-231 hydroxyacid oxidase 1 Homo sapiens 295-298 32692754-7 2020 Co-administration of kaempferol and zinc gluconate ameliorated noise-induced oxidative stress as demonstrated by the significantly increased activities of GPx, catalase, and SOD, and decreased levels of NO and MDA (P < 0.05 and P < 0.01 respectively), compared to the DW + N group. gluconic acid 36-50 catalase Rattus norvegicus 160-168 32536169-4 2020 In addition, by changing the pH dynamically using glucose oxidase (GOx)-catalyzed oxidation of glucose to gluconic acid, the direction of fluid pumping can be altered in situ, allowing for the design of a glucose sensor. gluconic acid 106-119 hydroxyacid oxidase 1 Homo sapiens 67-70 32138507-4 2020 GOx in the MOF, as the glucose-responsive factor, could catalyze glucose into gluconic acid with the formation of H2O2 as the byproduct. gluconic acid 78-91 hydroxyacid oxidase 1 Homo sapiens 0-3 32629825-4 2020 Glucose can passively diffuse into the pores and become oxidized to gluconic acid by GOx, thereby causing a decrease in local pH. gluconic acid 68-81 hydroxyacid oxidase 1 Homo sapiens 85-88 31978443-3 2020 After entering the cavities of ZIF-8, glucose can be oxidized into gluconic acid by GOx, causing a decrease in local pH. gluconic acid 67-80 hydroxyacid oxidase 1 Homo sapiens 84-87 32233414-6 2020 GOx catalyzes the oxidation of glucose, which generates hydrogen peroxide and gluconic acid, leading to the starvation therapy via glucose consumption in cancer cells, as well as the disruption of cellular redox balance. gluconic acid 78-91 hydroxyacid oxidase 1, liver Mus musculus 0-3 32156109-2 2020 In this study, a robust and easy-to-use multienzymatic cascade reaction system of coimmobilized GA@GOx hybrid nanoflowers with a specific spatial distribution of enzymes by compartmentalization was constructed and applied to catalyze starch to gluconic acid in one pot. gluconic acid 244-257 hydroxyacid oxidase 1 Homo sapiens 99-102 32156109-7 2020 The final results indicated that the overall enzyme activity of the GA@GOx hybrid nanoflowers increased by 1.5 times, and the conversion efficiency was 92.12% within 80 min significantly superior to the free multienzyme system, which showed the outstanding conversion of starch into gluconic acid in one pot. gluconic acid 283-296 hydroxyacid oxidase 1 Homo sapiens 71-74 32138507-5 2020 The gluconic acid formed decreases the local pH in MOFs, resulting in the degradation of MOFs and thus preloaded insulin would be released. gluconic acid 4-17 insulin Homo sapiens 113-120 32038274-11 2019 In vitro, the Nrf2 protein level was downregulated in mpkCCD cells after NaCl treatment for 24 h. Interestingly, sodium gluconate had a similar effect on downregulating Nrf2 expression as NaCl, whereas neither Choline-Cl nor mannitol changed Nrf2 expression. gluconic acid 113-129 nuclear factor, erythroid derived 2, like 2 Mus musculus 14-18 31889346-3 2020 The addition of increasing glucose concentrations promotes the release of insulin due to the disassembly of the GI-PSAs triggered by the catalytic in-situ formation of gluconic acid. gluconic acid 168-181 insulin Homo sapiens 74-81 32031792-12 2020 Glucose permeates across the two hydrogel layers resulting in the glucose oxidase catalyzed aerobic oxidation of glucose to gluconic acid. gluconic acid 124-137 hydroxyacid oxidase 1 Homo sapiens 66-81 32038274-11 2019 In vitro, the Nrf2 protein level was downregulated in mpkCCD cells after NaCl treatment for 24 h. Interestingly, sodium gluconate had a similar effect on downregulating Nrf2 expression as NaCl, whereas neither Choline-Cl nor mannitol changed Nrf2 expression. gluconic acid 113-129 nuclear factor, erythroid derived 2, like 2 Mus musculus 169-173 32038274-11 2019 In vitro, the Nrf2 protein level was downregulated in mpkCCD cells after NaCl treatment for 24 h. Interestingly, sodium gluconate had a similar effect on downregulating Nrf2 expression as NaCl, whereas neither Choline-Cl nor mannitol changed Nrf2 expression. gluconic acid 113-129 nuclear factor, erythroid derived 2, like 2 Mus musculus 169-173 32038274-12 2019 Meanwhile, the mRNA levels of Nrf2 target genes were downregulated by NaCl and/or sodium gluconate, while some of them were also regulated by Choline-Cl, indicating a more complex regulation of these genes under a high salt condition. gluconic acid 82-98 nuclear factor, erythroid derived 2, like 2 Mus musculus 30-34 31722522-3 2019 Specifically, Pt blocks deoxyribonucleic acid (DNA) replication and activates hydrogen peroxide (H2O2) generation for chemotherapy; GOx consumes glucose to produce H2O2 and gluconic acid for starvation therapy; and all H2O2 products are catalyzed by ferrous ions decomposed from ferrocene to generate the highly toxic hydroxyl radicals ( OH) for chemodynamic therapy. gluconic acid 173-186 hydroxyacid oxidase 1, liver Mus musculus 132-135 31833533-3 2020 When the iRGMs were mixed with whole blood samples, GOx can convert blood glucose into gluconic acid, as well as H2O2, which will reduce MnO2 and decompose the iRGMs. gluconic acid 87-100 hydroxyacid oxidase 1 Homo sapiens 52-55 31569698-0 2019 Co-Immobilization of Glucose Dehydrogenase and Xylose Dehydrogenase as a New Approach for Simultaneous Production of Gluconic and Xylonic Acid. gluconic acid 117-125 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 21-42 31747128-1 2019 Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O2 ) to produce hydrogen peroxide (H2 O2 ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation. gluconic acid 118-131 hydroxyacid oxidase 1 Homo sapiens 0-15 31747128-1 2019 Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O2 ) to produce hydrogen peroxide (H2 O2 ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation. gluconic acid 118-131 hydroxyacid oxidase 1 Homo sapiens 17-20 31569698-0 2019 Co-Immobilization of Glucose Dehydrogenase and Xylose Dehydrogenase as a New Approach for Simultaneous Production of Gluconic and Xylonic Acid. gluconic acid 117-125 xanthine dehydrogenase Homo sapiens 47-67 31569698-3 2019 Therefore, in this work we have undertaken a study focused on the co-immobilization of glucose dehydrogenase (GDH, EC 1.1.1.118) and xylose dehydrogenase (XDH, EC 1.1.1.175) using mesoporous Santa Barbara Amorphous silica (SBA 15) for the simultaneous production of gluconic acid and xylonic acid. gluconic acid 266-279 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 87-108 31569698-3 2019 Therefore, in this work we have undertaken a study focused on the co-immobilization of glucose dehydrogenase (GDH, EC 1.1.1.118) and xylose dehydrogenase (XDH, EC 1.1.1.175) using mesoporous Santa Barbara Amorphous silica (SBA 15) for the simultaneous production of gluconic acid and xylonic acid. gluconic acid 266-279 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 110-113 31569698-3 2019 Therefore, in this work we have undertaken a study focused on the co-immobilization of glucose dehydrogenase (GDH, EC 1.1.1.118) and xylose dehydrogenase (XDH, EC 1.1.1.175) using mesoporous Santa Barbara Amorphous silica (SBA 15) for the simultaneous production of gluconic acid and xylonic acid. gluconic acid 266-279 xanthine dehydrogenase Homo sapiens 133-153 31569698-3 2019 Therefore, in this work we have undertaken a study focused on the co-immobilization of glucose dehydrogenase (GDH, EC 1.1.1.118) and xylose dehydrogenase (XDH, EC 1.1.1.175) using mesoporous Santa Barbara Amorphous silica (SBA 15) for the simultaneous production of gluconic acid and xylonic acid. gluconic acid 266-279 xanthine dehydrogenase Homo sapiens 155-158 31351968-8 2019 KEY FINDINGS: Berberine and zinc gluconate pretreatment to CLP rats improved survival rate, reduced plasma endotoxin level, alleviated hypozincemia, increased zinc accumulation and ZIP14 mRNA expression in the intestinal mucosa. gluconic acid 28-42 solute carrier family 39 member 14 Homo sapiens 181-186 31048253-7 2019 In the INAzymes system, glucose is converted to gluconic acid by GOx in the presence of oxygen to produce H2O2 as an intermediate. gluconic acid 48-61 hydroxyacid oxidase 1 Homo sapiens 65-68 31361291-2 2019 Once internalized by tumor cells, GOX catalyzes endogenous glucose into hydrogen peroxide (H2O2) and gluconic acid (H+) enabling starvation therapy through choking off energy (glucose) supply. gluconic acid 101-114 hydroxyacid oxidase 1 Homo sapiens 34-37 31236648-9 2019 In the presence of GOx, glucose oxidizes to gluconic acid and H2O2, so the original level of glucose can be estimated by determining the H2O2 present. gluconic acid 44-57 hydroxyacid oxidase 1 Homo sapiens 19-22 31351968-12 2019 Berberine and IGF-I treatment increased ZIP14 protein expression and promoted zinc transfer into Caco-2 cells exposed to zinc gluconate plus LPS. gluconic acid 121-135 insulin like growth factor 1 Homo sapiens 14-19 31252482-6 2019 GOx can catalyze the conversion of glucose into gluconic acid and H2O2, which can elevate acidity in the tumor microenvironment and boost Fe3O4-based Fenton reaction, producing a myriad of OH to induce tumor cell death. gluconic acid 48-61 hydroxyacid oxidase 1 Homo sapiens 0-3 30280731-4 2018 Accompanying the formation of the sandwiched immunocomplexes, the loaded GOx molecules in the microsphere could catalyze glucose into gluconic acid and hydrogen peroxide. gluconic acid 134-147 hydroxyacid oxidase 1 Homo sapiens 73-76 31002497-7 2019 Nontoxic glucose can be continuously converted into abundant gluconic acid and H2O2 by GOx, avoiding the direct use of relatively high concentrated and toxic H2O2 and minimizing the harmful side effects. gluconic acid 61-74 hydroxyacid oxidase 1 Homo sapiens 87-90 30907460-2 2019 GOx can effectively catalyze the oxidation of glucose into gluconic acid and hydrogen peroxide. gluconic acid 59-72 hydroxyacid oxidase 1 Homo sapiens 0-3 30865742-4 2019 In the slightly acidic environment of cancer cells, GOx is released and it consumes d-glucose and molecular oxygen, nutrients essential for the survival of cancer cells, and produces gluconic acid and hydrogen peroxide, respectively. gluconic acid 183-196 hydroxyacid oxidase 1 Homo sapiens 52-55 30865742-5 2019 The produced gluconic acid increases the acidity of the tumor microenvironment leading to complete MOF destruction and enhances hemoglobin and GOx release. gluconic acid 13-26 hydroxyacid oxidase 1 Homo sapiens 143-146 31066555-1 2019 The complexation equilibria between Mg2+ and d-gluconate (Gluc-) ions are of particular importance in modeling the chemical speciation in low- and intermediate-level radioactive waste repositories. gluconic acid 45-56 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 58-62 31088565-0 2019 Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. gluconic acid 0-9 chloride channel, voltage-sensitive 3 Mus musculus 73-78 31088565-2 2019 Here, we report that gluconate inhibits neonatal seizure by inhibiting CLC-3 chloride channels. gluconic acid 21-30 chloride channel, voltage-sensitive 3 Mus musculus 71-76 31088565-4 2019 Blocking CLC-3 Cl- channels by gluconate inhibits seizure activity both in neonatal brain slices and in neonatal animals with in vivo EEG recordings. gluconic acid 31-40 chloride channel, voltage-sensitive 3 Mus musculus 9-14 31088565-7 2019 Our studies suggest that gluconate can suppress neonatal seizure activities through inhibiting CLC-3 Cl- channels in developing brains. gluconic acid 25-34 chloride channel, voltage-sensitive 3 Mus musculus 95-100 30724188-1 2019 To achieve efficient one-step production of gluconic acid, cascade reactions of glucose oxidase (GOD) and catalase (CAT) have been advocated in the biocatalysis system. gluconic acid 44-57 catalase Homo sapiens 106-114 30724188-1 2019 To achieve efficient one-step production of gluconic acid, cascade reactions of glucose oxidase (GOD) and catalase (CAT) have been advocated in the biocatalysis system. gluconic acid 44-57 catalase Homo sapiens 116-119 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 158-174 catalase Homo sapiens 69-72 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 158-174 catalase Homo sapiens 237-240 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 179-192 catalase Homo sapiens 69-72 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 179-192 catalase Homo sapiens 237-240 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 165-174 catalase Homo sapiens 69-72 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 165-174 catalase Homo sapiens 237-240 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 289-302 catalase Homo sapiens 69-72 30724188-6 2019 The conversion of glucose under adequate air by co-localized GOD&CAT sustained the activity more than 90% after repeated utilization in the production of sodium gluconate and gluconic acid, suggesting that the co-immobilized GOD&CAT could be a promising catalyst for gluconate and gluconic acid production in some chemical and food industries. gluconic acid 289-302 catalase Homo sapiens 237-240 30217016-5 2018 Expressed in Xenopus oocytes, the inside-out patch-clamp configuration showed single channels with a conductance of about 46 pS and 39 pS for hemichannels composed of hCx46 and hCx26 monomers, respectively, when chloride was replaced by gluconate on both membrane sides. gluconic acid 237-246 gap junction protein alpha 3 Homo sapiens 167-172 30077007-6 2018 Substitution of gluconate or aspartate for chloride in the bath solution blocked voltage-gated outward currents and shifted the reversal potential of Panx1 currents to the right, indicating the anion permeability of this channel. gluconic acid 16-25 pannexin 1 Mus musculus 150-155 30217016-5 2018 Expressed in Xenopus oocytes, the inside-out patch-clamp configuration showed single channels with a conductance of about 46 pS and 39 pS for hemichannels composed of hCx46 and hCx26 monomers, respectively, when chloride was replaced by gluconate on both membrane sides. gluconic acid 237-246 gap junction protein beta 2 Homo sapiens 177-182 30073791-3 2018 Self-assembled from a well-designed amphiphilic host-guest complex formed by pillar[5]arene and a diphenylboronic acid derivative and loaded with insulin and glucose oxidase, the obtained insulin-GOx-loaded supramolecular vesicles can selectively recognize glucose, accompanied by the structure disruption and efficient release of the entrapped insulin triggered by the high glucose concentration as well as the in situ generated H2 O2 and acid microenvironment during the GOx-promoted specific oxidation of glucose into gluconic acid. gluconic acid 521-534 hydroxyacid oxidase 1, liver Mus musculus 196-199 33435111-5 2018 GOx/CAT in the MBGs could catalyze glucose to form gluconic acid, resulting decrease in the local pH. gluconic acid 51-64 hydroxyacid oxidase 1 Homo sapiens 0-3 30024579-3 2018 GOx efficiently catalyzes the oxidization of glucose into gluconic acid and hydrogen peroxide (H2O2), which can be employed by various biosensors for the detection of cancer biomarkers. gluconic acid 58-71 hydroxyacid oxidase 1 Homo sapiens 0-3 29969227-2 2018 The ZIF-8 NMOFs are loaded with the respective drug and glucose oxidase (GOx), and the GOx-mediated aerobic oxidation of glucose yields gluconic acid and H2O2. gluconic acid 136-149 hydroxyacid oxidase 1 Homo sapiens 56-71 29969227-2 2018 The ZIF-8 NMOFs are loaded with the respective drug and glucose oxidase (GOx), and the GOx-mediated aerobic oxidation of glucose yields gluconic acid and H2O2. gluconic acid 136-149 hydroxyacid oxidase 1 Homo sapiens 73-76 29969227-2 2018 The ZIF-8 NMOFs are loaded with the respective drug and glucose oxidase (GOx), and the GOx-mediated aerobic oxidation of glucose yields gluconic acid and H2O2. gluconic acid 136-149 hydroxyacid oxidase 1 Homo sapiens 87-90 33435111-5 2018 GOx/CAT in the MBGs could catalyze glucose to form gluconic acid, resulting decrease in the local pH. gluconic acid 51-64 catalase Homo sapiens 4-7 29656196-5 2018 The HILIC-MS/MS method showed a high sensitivity (LOD = 0.98 mug L-1 for hexonic acid), a good repeatability (RSD of peak area less than 1.669%), accuracy (92.9%-104.2%), recovery (97.6%-99.3%) and a wide linear range. gluconic acid 73-85 immunoglobulin kappa variable 1-16 Homo sapiens 65-68 29623975-4 2018 When hyperglycemia is encountered, the enzymatic conversion of glucose into gluconic acid leads to a decrease in the local pH, and the hydrogel is disassembled because of the strong inter- and intramolecular electrostatic repulsions between ornithine (Orn) residues; this is followed by the release of insulin. gluconic acid 76-89 insulin Homo sapiens 302-309 29633614-2 2018 Upon the specific uptake of MG/HA by CD44 overexpressed cancer cells, GOD catalyzed the oxidation of glucose into gluconic acid and hydrogen peroxide (H2O2) accompanying the consumption of oxygen (O2). gluconic acid 114-127 CD44 molecule (Indian blood group) Homo sapiens 37-41 29421303-4 2018 In this system, glucose can be broken down into gluconic acid and hydrogen peroxide by GOx-INS-ER, and the latter will rupture the erythrocyte membrane to release INS within minutes. gluconic acid 48-61 hydroxyacid oxidase 1, liver Mus musculus 87-90 29501862-0 2018 Configuration-dependent complex formation between Ca(II) and sugar carboxylate ligands in alkaline medium: Comparison of L-gulonate with D-gluconate and D-heptaguconate. gluconic acid 137-148 carbonic anhydrase 2 Homo sapiens 50-56 29438880-2 2018 Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and oxygen into gluconic acid and H2O2. gluconic acid 168-181 hydroxyacid oxidase 1, liver Mus musculus 8-23 29438880-2 2018 Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and oxygen into gluconic acid and H2O2. gluconic acid 168-181 hydroxyacid oxidase 1, liver Mus musculus 25-28 29185908-2 2017 In the present study, the growth inhibition kinetics of recombinant P. pastoris expressing human interferon gamma was studied under different initial substrate concentrations of gluconate (10-100 g L-1) and methanol (2-50 g L-1) in modified FM22 medium. gluconic acid 178-187 interferon gamma Homo sapiens 97-113 29051100-9 2018 The present work demonstrates that the immobilized bi-enzyme (GOD/CAT@IO-SiO2) is not only a very promising system for glucose removal but also has great potential for applications in production of gluconic acid, preparation of biosensors, enzyme bioreactors, etc. gluconic acid 198-211 catalase Homo sapiens 66-69 29207127-4 2018 The labelling of MTX was carried out via a 99mTc-gluconate precursor. gluconic acid 48-58 metaxin 1 Homo sapiens 17-20 29185908-3 2017 The highest specific growth rate of 0.0206 and 0.019 hr-1 was observed at 60 g L-1 of gluconate and 10 g L-1 of methanol, respectively. gluconic acid 86-95 L1 cell adhesion molecule Homo sapiens 79-82 28858729-5 2017 RESULTS: Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- alpha), interleukins-6 1 beta, inflammatory8 (IFN ou), pancreatic 1L1-beta along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). gluconic acid 53-67 C-reactive protein Rattus norvegicus 153-171 28858729-5 2017 RESULTS: Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- alpha), interleukins-6 1 beta, inflammatory8 (IFN ou), pancreatic 1L1-beta along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). gluconic acid 53-67 C-reactive protein Rattus norvegicus 173-176 28858729-5 2017 RESULTS: Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- alpha), interleukins-6 1 beta, inflammatory8 (IFN ou), pancreatic 1L1-beta along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). gluconic acid 53-67 tumor necrosis factor Rattus norvegicus 179-206 28858729-5 2017 RESULTS: Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- alpha), interleukins-6 1 beta, inflammatory8 (IFN ou), pancreatic 1L1-beta along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). gluconic acid 53-67 tumor necrosis factor Rattus norvegicus 208-218 28858729-5 2017 RESULTS: Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- alpha), interleukins-6 1 beta, inflammatory8 (IFN ou), pancreatic 1L1-beta along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). gluconic acid 53-67 solute carrier family 30 member 8 Rattus norvegicus 340-358 28858729-5 2017 RESULTS: Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- alpha), interleukins-6 1 beta, inflammatory8 (IFN ou), pancreatic 1L1-beta along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). gluconic acid 53-67 solute carrier family 30 member 8 Rattus norvegicus 360-364 28971188-3 2017 Because of its limited availability, d-gluconate (Gluc-) is commonly used as a structural and functional model of Isa-. gluconic acid 37-48 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 50-54 29404057-3 2017 physicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like PXRD, PSA, FT-IR, UV-Vis spectroscopy, TGA/DTG, and DSC. gluconic acid 42-61 T-box transcription factor 1 Homo sapiens 148-151 28647826-1 2017 Closed-loop insulin delivery system works on pH modulation by gluconic acid production from glucose, which in turn allows regulation of insulin release across membrane. gluconic acid 62-75 insulin Homo sapiens 12-19 28647826-1 2017 Closed-loop insulin delivery system works on pH modulation by gluconic acid production from glucose, which in turn allows regulation of insulin release across membrane. gluconic acid 62-75 insulin Homo sapiens 136-143 29404057-8 2017 The TGA/DTG thermograms of the analyte indicated that magnesium gluconate was thermally stable up to around 165 C. Consequently, the melting temperature of magnesium gluconate was found to be 169.90 C along with the enthalpy of fusion of 308.7 J/g. gluconic acid 54-73 T-box transcription factor 1 Homo sapiens 4-7 28752954-8 2017 The release of promoter bound GntR is induced by gluconate and 6-phosphogluconate that bind with similar apparent affinities to the GntR/DNA complex. gluconic acid 49-58 GntR family transcriptional regulator Pseudomonas aeruginosa PAO1 30-34 28660924-6 2017 It was found that GOx immobilized on the modified SiO2 using glutardialdehyde as a crosslinking agent was the most active and stable catalytic system, showing an 85% yield of gluconic acid. gluconic acid 175-188 hydroxyacid oxidase 1 Homo sapiens 18-21 28752954-8 2017 The release of promoter bound GntR is induced by gluconate and 6-phosphogluconate that bind with similar apparent affinities to the GntR/DNA complex. gluconic acid 49-58 GntR family transcriptional regulator Pseudomonas aeruginosa PAO1 132-136 28656770-10 2017 The aerobic oxidation of glucose in the presence of glucose oxidase, GOx, yields gluconic acid and H2O2. gluconic acid 81-94 hydroxyacid oxidase 1 Homo sapiens 69-72 27802606-6 2016 The killer capsules harvest glucose from their surroundings, which is then enzymatically converted by GOx into gluconate ions. gluconic acid 111-120 hydroxyacid oxidase 1 Homo sapiens 102-105 28650613-1 2017 Glucose oxidase (GOX) can convert glucose into gluconic acid and hydrogen peroxide (H2O2), which is potentially useful for synergistic cancer-starving and oxidation therapy. gluconic acid 47-60 hydroxyacid oxidase 1 Homo sapiens 0-15 28650613-1 2017 Glucose oxidase (GOX) can convert glucose into gluconic acid and hydrogen peroxide (H2O2), which is potentially useful for synergistic cancer-starving and oxidation therapy. gluconic acid 47-60 hydroxyacid oxidase 1 Homo sapiens 17-20 28107976-4 2017 In this assay, GOx-catalyzed oxidization of glucose produces gluconic acid and hydrogen peroxide (H2O2). gluconic acid 61-74 hydroxyacid oxidase 1 Homo sapiens 15-18 27904934-0 2017 Part-2: Analytical Expressions of Concentrations of Glucose, Oxygen, and Gluconic Acid in a Composite Membrane for Closed-Loop Insulin Delivery for the Non-steady State Conditions. gluconic acid 73-86 insulin Homo sapiens 127-134 27936311-2 2017 Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. gluconic acid 82-95 hydroxyacid oxidase 1 Homo sapiens 24-39 27936311-2 2017 Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. gluconic acid 82-95 hydroxyacid oxidase 1 Homo sapiens 41-44 27838499-7 2017 Interestingly, extracellular Cl--free condition created by replacing Cl- with equimolar gluconate resulted in a decrease in [Cl-]i and induced protective effects similar to SQS preconditioning, whereas pharmacologically opening of the mPTP with ATR abolished all the protective effects induced by SQS or Cl--free, including suppression of mPTP opening, maintenance of mitochondrial membrane potential, and subsequent improvement of mitochondrial function. gluconic acid 88-97 protein tyrosine phosphatase, receptor type, U Mus musculus 235-239 27838499-7 2017 Interestingly, extracellular Cl--free condition created by replacing Cl- with equimolar gluconate resulted in a decrease in [Cl-]i and induced protective effects similar to SQS preconditioning, whereas pharmacologically opening of the mPTP with ATR abolished all the protective effects induced by SQS or Cl--free, including suppression of mPTP opening, maintenance of mitochondrial membrane potential, and subsequent improvement of mitochondrial function. gluconic acid 88-97 protein tyrosine phosphatase, receptor type, U Mus musculus 339-343 27979773-0 2017 Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice. gluconic acid 0-14 metallothionein 1 Mus musculus 41-46 27696329-8 2016 Immunostaining, Western blot analysis and light microscopy revealed that potassium gluconate exposure delayed cell fusion and maintained a higher population of cells expressing the muscle stem cell marker Pax7. gluconic acid 73-92 paired box 7 Homo sapiens 205-209 27589853-0 2017 Genipin Cross-Linked Glucose Oxidase and Catalase Multi-enzyme for Gluconic Acid Synthesis. gluconic acid 67-80 catalase Homo sapiens 41-49 27589853-1 2017 In this work, glucose oxidase (GOD) and catalase (CAT) were used simultaneously to produce gluconic acid from glucose. gluconic acid 91-104 catalase Homo sapiens 40-48 27589853-1 2017 In this work, glucose oxidase (GOD) and catalase (CAT) were used simultaneously to produce gluconic acid from glucose. gluconic acid 91-104 catalase Homo sapiens 50-53 27589853-3 2017 Improvements in gluconic acid production were due to quick removal of harmful intermediate hydrogen peroxide by CAT. gluconic acid 16-29 catalase Homo sapiens 112-115 27859880-4 2017 Glucose is transformed by GOx into gluconic acid, which promoted the dethreading of the benzimidazole-CD-GOx inclusion complexes, allowing cargo release. gluconic acid 35-48 hydroxyacid oxidase 1 Homo sapiens 26-29 27859880-4 2017 Glucose is transformed by GOx into gluconic acid, which promoted the dethreading of the benzimidazole-CD-GOx inclusion complexes, allowing cargo release. gluconic acid 35-48 hydroxyacid oxidase 1 Homo sapiens 105-108 27868112-8 2016 Similarly to oxidations mediated by certain LPMOs, thorough MS/MS-analysis of selected products and comparison with synthesised standards confirmed two types of glycosidic cleavage cascades induced by HO -mediated H-atom abstraction at C1 and C3/C4, producing gluconic acids, native oligosaccharides, and oxo-oligomers (carbonyl at non-reducing end). gluconic acid 260-274 heterogeneous nuclear ribonucleoprotein C Homo sapiens 236-248 26395757-3 2015 The results shown that both zinc sulfate and zinc gluconate addition increased the intracellular zinc concentration and influenced the expression of zinc transporters (Slc30a1 and Slc39a1) in a time-dependent manner. gluconic acid 45-59 solute carrier family 30 (zinc transporter), member 1 Mus musculus 168-175 27211694-2 2016 This study combines the use of glucose oxidase and catalase activities with the aim of rapid conversion of glucose into non-fermentable gluconic acid. gluconic acid 136-149 catalase Vitis vinifera 51-59 27189366-7 2016 Molecular docking studies suggest the possibility that oppositely charged substitution at residue E574 may disturb the interaction between the substrates and Pdr5p, resulting in impaired transport activity. gluconic acid 98-102 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 158-163 26999507-3 2016 The microneedle is composed of biocompatible hyaluronic acid integrated with pH-sensitive dextran nanoparticles (NPs) that encapsulate aPD1 and glucose oxidase (GOx), which converts blood glucose to gluconic acid. gluconic acid 199-212 hydroxyacid oxidase 1, liver Mus musculus 144-159 26999507-3 2016 The microneedle is composed of biocompatible hyaluronic acid integrated with pH-sensitive dextran nanoparticles (NPs) that encapsulate aPD1 and glucose oxidase (GOx), which converts blood glucose to gluconic acid. gluconic acid 199-212 hydroxyacid oxidase 1, liver Mus musculus 161-164 26752097-3 2016 The nanopipettes were functionalized as glucose nanosensors by immobilizing glucose oxidase (GOx) covalently to the tip so that the interaction of glucose with GOx resulted in a catalytic oxidation of beta-d-glucose to d-gluconic acid, which was measured as a change in impedance due to drop in pH of the medium at the nanopipette tip. gluconic acid 219-234 hydroxyacid oxidase 1 Homo sapiens 76-91 26752097-3 2016 The nanopipettes were functionalized as glucose nanosensors by immobilizing glucose oxidase (GOx) covalently to the tip so that the interaction of glucose with GOx resulted in a catalytic oxidation of beta-d-glucose to d-gluconic acid, which was measured as a change in impedance due to drop in pH of the medium at the nanopipette tip. gluconic acid 219-234 hydroxyacid oxidase 1 Homo sapiens 93-96 26752097-3 2016 The nanopipettes were functionalized as glucose nanosensors by immobilizing glucose oxidase (GOx) covalently to the tip so that the interaction of glucose with GOx resulted in a catalytic oxidation of beta-d-glucose to d-gluconic acid, which was measured as a change in impedance due to drop in pH of the medium at the nanopipette tip. gluconic acid 219-234 hydroxyacid oxidase 1 Homo sapiens 160-163 27518716-3 2016 To trace glucose in blood serum, owing to the reduced pH value caused by the production of gluconic acid in the GOx-catalyzed oxidation reaction, the bonding force between GOx and polyelectrolyte weakens, making GOx drop off from the sensing chip. gluconic acid 91-104 hydroxyacid oxidase 1 Homo sapiens 112-115 27518716-3 2016 To trace glucose in blood serum, owing to the reduced pH value caused by the production of gluconic acid in the GOx-catalyzed oxidation reaction, the bonding force between GOx and polyelectrolyte weakens, making GOx drop off from the sensing chip. gluconic acid 91-104 hydroxyacid oxidase 1 Homo sapiens 172-175 27518716-3 2016 To trace glucose in blood serum, owing to the reduced pH value caused by the production of gluconic acid in the GOx-catalyzed oxidation reaction, the bonding force between GOx and polyelectrolyte weakens, making GOx drop off from the sensing chip. gluconic acid 91-104 hydroxyacid oxidase 1 Homo sapiens 172-175 26544022-4 2016 In a Hexokinase 2 and Glucokinase 1 deleted strain (hxk2Deltaglk1Delta), glucose flux was diverted away from glycolysis and into a model pathway, gluconate, by controlling the transcription of Hexokinase 1 with the tetracycline transactivator protein (tTA). gluconic acid 146-155 hexokinase 2 Saccharomyces cerevisiae S288C 5-17 26544022-4 2016 In a Hexokinase 2 and Glucokinase 1 deleted strain (hxk2Deltaglk1Delta), glucose flux was diverted away from glycolysis and into a model pathway, gluconate, by controlling the transcription of Hexokinase 1 with the tetracycline transactivator protein (tTA). gluconic acid 146-155 hexokinase 1 Saccharomyces cerevisiae S288C 193-205 26544022-5 2016 A maximum 10-fold decrease in hexokinase activity resulted in a 50-fold increase in gluconate yields, from 0.7% to 36% mol/mol of glucose. gluconic acid 84-93 hexokinase Saccharomyces cerevisiae S288C 30-40 26278045-6 2016 With the assistant of glucose oxidase (GOx), the released glucose can react with the dissolved oxgen to produce gluconic acid and H2O2, the latter can enhance the CL of luminol in the NaOH solution. gluconic acid 112-125 hydroxyacid oxidase 1 Homo sapiens 22-37 26278045-6 2016 With the assistant of glucose oxidase (GOx), the released glucose can react with the dissolved oxgen to produce gluconic acid and H2O2, the latter can enhance the CL of luminol in the NaOH solution. gluconic acid 112-125 hydroxyacid oxidase 1 Homo sapiens 39-42 26395757-3 2015 The results shown that both zinc sulfate and zinc gluconate addition increased the intracellular zinc concentration and influenced the expression of zinc transporters (Slc30a1 and Slc39a1) in a time-dependent manner. gluconic acid 45-59 solute carrier family 39 (zinc transporter), member 1 Mus musculus 180-187 25839331-5 2015 Such aerobic systems, involved in gluconic acid production and phosphate solubilization, essentially require the pyrroloquinoline quinine (PQQ)- dependent glucose dehydrogenase (GDH) in the genome. gluconic acid 34-47 glutamate dehydrogenase Solanum lycopersicum 178-181 25888969-0 2015 Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration. gluconic acid 95-114 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 21-37 24865662-0 2014 Multinuclear complex formation between Ca(II) and gluconate ions in hyperalkaline solutions. gluconic acid 50-59 carbonic anhydrase 2 Homo sapiens 39-45 25309319-10 2014 However, ATP release evoked by potassium gluconate application was reduced in Panx1(-/-) mice. gluconic acid 31-50 pannexin 1 Mus musculus 78-83 24910038-1 2014 Gold nanoparticles (AuNPs) can oxidize glucose, producing hydrogen peroxide and gluconic acid, which are the same products as those generated by glucose oxidase (GOx). gluconic acid 80-93 hydroxyacid oxidase 1 Homo sapiens 145-160 24910038-1 2014 Gold nanoparticles (AuNPs) can oxidize glucose, producing hydrogen peroxide and gluconic acid, which are the same products as those generated by glucose oxidase (GOx). gluconic acid 80-93 hydroxyacid oxidase 1 Homo sapiens 162-165 26461290-7 2014 The results of this randomized double-blind placebo-controlled trial show that supplementation with vitamin C, vitamin E (as alpha tocopherol), zinc gluconate and selenomethionine in patients with FSHD significantly improves the maximal voluntary contraction and endurance of both quadriceps by enhancing the antioxidants defences and reducing oxidative stress. gluconic acid 144-158 FSHMD1A Homo sapiens 197-201 25171321-5 2014 Purified hVDAC3 allowed the passage of both chloride and gluconate anions and did not distinguish between potassium, sodium and calcium used as cations. gluconic acid 57-66 voltage dependent anion channel 3 Homo sapiens 9-15 24682480-1 2014 Gluconic acid secretion mediated by the direct oxidation of glucose by pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase (GDH) is responsible for mineral phosphate solubilization in Gram-negative bacteria. gluconic acid 0-13 SDR family oxidoreductase Herbaspirillum seropedicae 112-133 24682480-1 2014 Gluconic acid secretion mediated by the direct oxidation of glucose by pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase (GDH) is responsible for mineral phosphate solubilization in Gram-negative bacteria. gluconic acid 0-13 SDR family oxidoreductase Herbaspirillum seropedicae 135-138 24682480-4 2014 Transformants Hs (pSS2) and Hs (pOK53) secreted micromolar levels of PQQ and attained high GDH activity leading to secretion of 33.46 mM gluconic acid when grown on 50 mM glucose while Hs (pJNK1) was ineffective. gluconic acid 137-150 SDR family oxidoreductase Herbaspirillum seropedicae 91-94 24863931-3 2014 The permeability ratio sequence determined by substituting Cl(-) with other anions (PX/PCl) was SCN(-) > I(-) > NO3 (-) > Br(-) > Cl(-) > F(-) > gluconate. gluconic acid 163-172 NBL1, DAN family BMP antagonist Homo sapiens 118-121 24785462-3 2014 GOx-catalyzed oxidization of glucose leads to the formation of gluconic acid and hydrogen peroxide (H2O2). gluconic acid 63-76 hydroxyacid oxidase 1 Homo sapiens 0-3 24475083-7 2014 Zinc gluconate significantly reduced mean ALT (p<0.0001), AST (p<0.0001), GGT (p<0.0001) levels after 1 month, and urinary copper excretion after 6 months (p<0.0054). gluconic acid 0-14 solute carrier family 17 member 5 Homo sapiens 58-61 24475083-7 2014 Zinc gluconate significantly reduced mean ALT (p<0.0001), AST (p<0.0001), GGT (p<0.0001) levels after 1 month, and urinary copper excretion after 6 months (p<0.0054). gluconic acid 0-14 gamma-glutamyltransferase light chain 5 pseudogene Homo sapiens 74-77 23737455-7 2013 Univariate Cox regression and Kaplan-Meier analyses showed that levels of aminoadipic acid, gluconic acid and maltotriose were associated with the biochemical tumor recurrence (prostate-specific antigen > 0.2 ng/mL). gluconic acid 92-105 kallikrein related peptidase 3 Homo sapiens 177-202 23842530-7 2013 AQP5-L51R has the anion permeability sequence I(-) > NO3(-) NO2(-) > Br(-) > Cl(-) > HCO3(-) > gluconate. gluconic acid 112-121 aquaporin 5 Homo sapiens 0-4 24050935-10 2013 The gluconic acid-conjugated ATP@SPIONs, when conjugated with cMet-binding peptide, were successfully visualized on the U87MG tumors implanted in mice via multimodality imaging. gluconic acid 4-17 met proto-oncogene Mus musculus 62-66 23897548-1 2013 Contrary to suggestions in the literature, it has been proven that Al(III) forms a 1 : 1 complex with gluconate (hereafter Gluc(-)) in strongly alkaline (pH > 12) aqueous solutions. gluconic acid 102-111 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 123-127 23638642-4 2013 Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. gluconic acid 305-318 insulin Homo sapiens 97-104 23572517-11 2013 We profiled an additional set of relevant metabolic enzymes and transporters, including Crc targets, and showed that the Crc-regulated edd mutant (gluconate-6-phosphate dehydratase) had similar gluconate levels as the rpoN mutant. gluconic acid 147-156 ubiquitin protein ligase E3 component n-recognin 5 Homo sapiens 135-138 23562736-8 2013 Aga2-GOx fusion proteins in the yeast cell wall could also be used as immobilized catalysts for the production of gluconic acid. gluconic acid 114-127 Aga2p Saccharomyces cerevisiae S288C 0-4 23638642-4 2013 Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. gluconic acid 305-318 insulin Homo sapiens 223-230 23117226-0 2013 Analytical expressions for the steady-state concentrations of glucose, oxygen and gluconic acid in a composite membrane for closed-loop insulin delivery. gluconic acid 82-95 insulin Homo sapiens 136-143 23377928-4 2013 Of the glucose taken up by the cells, 9% was phosphorylated to glucose 6-phosphate, whereas 91% was oxidized by cytoplasmic glucose dehydrogenase to gluconate. gluconic acid 149-158 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family Gluconobacter oxydans 621H 124-145 23090569-6 2012 The PB-FCNF modified glassy carbon electrode (PB-FCNF/GCE) shows good electrocatalysis toward the reduction of H(2)O(2), a product from the reduction of O(2) followed by glucose oxidase (GOD) catalysis of the oxidation of glucose to gluconic acid. gluconic acid 233-246 aminomethyltransferase Homo sapiens 46-57 23345219-5 2013 This voltage response is mediated by the coordinated activation of Ca(2+)-dependent, TRAM-34-sensitive K(Ca)3.1 channels, and Ca(2+)-dependent, 4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid (DIDS)-sensitive and gluconate-sensitive Cl(-) channels. gluconic acid 217-226 translocation associated membrane protein 1 Homo sapiens 85-89 20338726-7 2010 Similarly, cell shrinkage by 48 h replacement of extracellular chloride with gluconate and oxidative stress (30 min exposure to 0.3 mM tert-butylhydroperoxide) triggered suicidal erythrocyte death as evident from enhanced annexin V-binding. gluconic acid 77-86 annexin A5 Homo sapiens 222-231 22311122-2 2012 Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-) glutamate (-) gluconate(-). gluconic acid 233-242 pannexin 1 Homo sapiens 31-36 23430849-6 2012 We successfully treated the patient with zinc gluconate and vitamin C, and we detected a novel homozygous c.541_551dup (p.Leu186fsX38) mutation in the exon 3 of her SLC39A4 gene. gluconic acid 41-55 solute carrier family 39 member 4 Homo sapiens 165-172 23251508-6 2012 Recognizing that porin assembly can be inhibited by zinc, we found that zinc gluconate inhibited potassium efflux from RBC exposed to total venom or purified porin, and prolonged survival time in mice following venom injection. gluconic acid 72-86 voltage dependent anion channel 1 Homo sapiens 17-22 23251508-6 2012 Recognizing that porin assembly can be inhibited by zinc, we found that zinc gluconate inhibited potassium efflux from RBC exposed to total venom or purified porin, and prolonged survival time in mice following venom injection. gluconic acid 72-86 voltage dependent anion channel 1 Homo sapiens 158-163 20599191-1 2010 Complexation of d-gluconate (Gluc(-)) with Ca(2+) has been investigated via (1)H, (13)C and (43)Ca NMR spectroscopy in aqueous solutions in the presence of high concentration background electrolytes (1MI4M (NaCl) ionic strength). gluconic acid 16-27 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 29-33 20583766-2 2010 An enzymatic oxygen scavenging system of glucose oxidase and catalase is widely used to improve the dye photostability but with the unfavorable side effect of producing gluconic acid. gluconic acid 169-182 catalase Homo sapiens 61-69 22854010-0 2012 Human beta-defensin-2 and psoriasin, two new innate immunity targets of zinc gluconate. gluconic acid 72-86 defensin beta 4A Homo sapiens 6-21 22854010-6 2012 RESULTS: We found that hBD-2 and psoriasin mRNA expression levels and hBD-2 extracellular release, but not hBD-4 expression and release, were significantly upregulated by zinc gluconate in LPS-stimulated inflammatory skin explants. gluconic acid 171-185 defensin beta 4A Homo sapiens 23-28 22854010-6 2012 RESULTS: We found that hBD-2 and psoriasin mRNA expression levels and hBD-2 extracellular release, but not hBD-4 expression and release, were significantly upregulated by zinc gluconate in LPS-stimulated inflammatory skin explants. gluconic acid 171-185 defensin beta 4A Homo sapiens 70-75 22854010-6 2012 RESULTS: We found that hBD-2 and psoriasin mRNA expression levels and hBD-2 extracellular release, but not hBD-4 expression and release, were significantly upregulated by zinc gluconate in LPS-stimulated inflammatory skin explants. gluconic acid 171-185 defensin beta 104B Homo sapiens 107-112 22854010-7 2012 CONCLUSION: These results suggest that hBD-2 and psoriasin may be two main targets of zinc gluconate, involved in its anti-inflammatory activity in dermatoses. gluconic acid 86-100 defensin beta 4A Homo sapiens 39-44 22509831-0 2012 Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-alpha in the epidermis. gluconic acid 0-14 peroxisome proliferator activated receptor alpha Homo sapiens 32-80 22509831-3 2012 The aim of our work was to determine whether the modulation of PPAR-alpha expression and activity could be one of the mechanisms of action of zinc gluconate anti-inflammatory activity in inflammatory dermatoses. gluconic acid 142-156 peroxisome proliferator activated receptor alpha Homo sapiens 63-73 22509831-7 2012 On the other hand, in inflammatory LPS-stimulated explants, zinc gluconate significantly upregulated PPAR-alpha function and mRNA expression level, without changing its epidermal protein expression. gluconic acid 60-74 peroxisome proliferator activated receptor alpha Homo sapiens 101-111 22509831-8 2012 These results suggest that zinc gluconate may be a PPAR-alpha agonist, which might play a role in the anti-inflammatory activity of this molecule. gluconic acid 27-41 peroxisome proliferator activated receptor alpha Homo sapiens 51-61 22318860-3 2012 When adding glucose and GOx to the aqueous solution of gelator 1 or the self-assembled fibrillar hydrogel of gelator 2 to construct glucose metabolism system, the metabolic product (gluconic acid) can trigger the protonation of the peptide molecules and induce the phase transitions of gelators 1 (sol-gel) and 2 (gel-sol). gluconic acid 182-195 hydroxyacid oxidase 1 Homo sapiens 24-27 22629867-4 2012 Here, GOx is harnessed for its unparalled level of catalytic activity and substrate specificity while H2O2 is produced as a by-product during the oxidation of D-glucose to gluconic acid by GOx. gluconic acid 172-185 hydroxyacid oxidase 1 Homo sapiens 6-9 22629867-4 2012 Here, GOx is harnessed for its unparalled level of catalytic activity and substrate specificity while H2O2 is produced as a by-product during the oxidation of D-glucose to gluconic acid by GOx. gluconic acid 172-185 hydroxyacid oxidase 1 Homo sapiens 189-192 21251218-7 2011 CT-induced I(SC) was blocked by replacing chloride in the bath solutions with equimolar gluconate and was significantly inhibited by the specific cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor, CFTR(127inh). gluconic acid 88-97 calcitonin related polypeptide alpha Homo sapiens 0-2 21424226-6 2011 The TMEM16A current could be strongly inhibited by niflumic acid, and when Cl(-) was substituted by gluconate ions, the current was reduced considerably. gluconic acid 100-109 anoctamin 1 Homo sapiens 4-11 20509693-3 2010 beta-Gal catalyzes the hydrolysis of lactose, and the produced glucose is catalytically oxidized to gluconic acid and H(2)O(2), which is reduced in the presence of HRP. gluconic acid 100-113 beta-galactosidase Theobroma cacao 0-8 20066046-2 2010 Our experiments showed that CaV1.2 currents expressed in HEK293 cells are strongly inhibited by replacing extracellular chloride with gluconate or perchlorate. gluconic acid 134-143 calcium voltage-gated channel subunit alpha1 C Homo sapiens 28-34 19771426-6 2010 RESULTS: Gluconate-mediated labelling of maGGG-Z(HER2:342) and maGSG-Z(HER2:342) with (186)Re provided a yield of more than 95% within 60 min. gluconic acid 9-18 erb-b2 receptor tyrosine kinase 2 Mus musculus 49-53 19771426-6 2010 RESULTS: Gluconate-mediated labelling of maGGG-Z(HER2:342) and maGSG-Z(HER2:342) with (186)Re provided a yield of more than 95% within 60 min. gluconic acid 9-18 erb-b2 receptor tyrosine kinase 2 Mus musculus 71-75 20107083-7 2010 Using a Cs(+)-gluconate-based internal solution, the leptin-activated current reversed near -20 mV. gluconic acid 10-23 leptin Mus musculus 53-59 20066046-4 2010 Inhibition of CaV1.2 currents produced by replacing chloride with gluconate was reduced from approximately 75%-80% to approximately 50% by omitting beta subunits but unaffected by omitting alpha(2)delta subunits. gluconic acid 66-75 calcium voltage-gated channel subunit alpha1 C Homo sapiens 14-20 20066046-10 2010 Expressing CaV1.2 channels that lacked both N and C termini reduced gluconate inhibition to approximately 25% consistent with additive interactions between the two tail regions. gluconic acid 68-77 calcium voltage-gated channel subunit alpha1 C Homo sapiens 11-17 19910681-8 2009 0.3 mM tert-butylhydroperoxide), energy depletion (48 h glucose removal) and isotonic cell shrinkage (48 h replacement of extracellular Cl(-) with gluconate) significantly increased annexin V-binding and decreased the forward scatter, effects significantly blunted in the presence of thymol 2.5 - 20 microg/ml. gluconic acid 147-156 annexin A5 Homo sapiens 182-191 19250168-2 2009 AIMS: In this study, we evaluated the in vitro effects of green coffee (C. arabica L.) oil (GCO) on the synthesis of collagen, elastin, and glycosaminoglycans (GAG) and in the release of transforming growth factor-beta1 (TGF-beta1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) by human skin fibroblasts. gluconic acid 92-95 elastin Homo sapiens 127-134 19250168-2 2009 AIMS: In this study, we evaluated the in vitro effects of green coffee (C. arabica L.) oil (GCO) on the synthesis of collagen, elastin, and glycosaminoglycans (GAG) and in the release of transforming growth factor-beta1 (TGF-beta1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) by human skin fibroblasts. gluconic acid 92-95 transforming growth factor beta 1 Homo sapiens 221-230 19250168-2 2009 AIMS: In this study, we evaluated the in vitro effects of green coffee (C. arabica L.) oil (GCO) on the synthesis of collagen, elastin, and glycosaminoglycans (GAG) and in the release of transforming growth factor-beta1 (TGF-beta1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) by human skin fibroblasts. gluconic acid 92-95 colony stimulating factor 2 Homo sapiens 286-292 17429031-8 2007 On the other hand, replacement of gluconate with Cl(-) decreased the K(m) value for the uptake of [(3)H]estrone sulfate and cefotiam by HEK-hOAT3 to about one-third, while it did not change the V(max) value. gluconic acid 34-43 solute carrier family 22 member 8 Homo sapiens 140-145 31130775-5 2008 The enzyme, glucose oxidase (GOX), was then electrostatically immobilized inside the functionalized membrane domains to study the catalytic oxidation of glucose to gluconic acid and H2O2. gluconic acid 164-177 hydroxyacid oxidase 1 Homo sapiens 12-27 31130775-5 2008 The enzyme, glucose oxidase (GOX), was then electrostatically immobilized inside the functionalized membrane domains to study the catalytic oxidation of glucose to gluconic acid and H2O2. gluconic acid 164-177 hydroxyacid oxidase 1 Homo sapiens 29-32 18769052-11 2008 Low Cl(-) solution (Cl(-) exchanged by gluconate for 48 hours) similarly increased annexin V-binding and decreased forward scatter, effects again reversed by caffeine (50-500 microM). gluconic acid 39-48 annexin A5 Homo sapiens 83-92 18499752-2 2008 Reduction in extracellular Cl(-) and equimolar substitution by the membrane-impermeant anions glutamate or gluconate significantly increased hCG-stimulated P4 accumulation. gluconic acid 107-116 chorionic gonadotropin subunit beta 5 Homo sapiens 141-144 18304565-4 2008 In Gox medium, no significant changes were observed in both oxygen concentration and Fe(ox)/Cr(ox) ratio, but the density of colloidal particles decreased, indicating a dissolution of Fe oxide/hydroxide under the influence of gluconate. gluconic acid 226-235 hydroxyacid oxidase 1 Homo sapiens 3-6 17429031-5 2007 The uptake of p-[(14)C]aminohippurate by HEK-hOAT1 and [(3)H]estrone sulfate by HEK-hOAT3 was greater in the presence of Cl(-) than in the presence of SO(4)(2-) or gluconate. gluconic acid 164-173 solute carrier family 22 member 6 Homo sapiens 45-50 17429031-6 2007 Additionally, the uptake of various compounds by HEK-hOAT1 and HEK-hOAT3 was significantly higher in the Cl(-)-containing medium than the gluconate-containing medium, suggesting that the influences of Cl(-) are not dependent on substrate and that Cl(-) directly stimulates the functions of hOAT1 and hOAT3. gluconic acid 138-147 solute carrier family 22 member 6 Homo sapiens 53-58 17429031-6 2007 Additionally, the uptake of various compounds by HEK-hOAT1 and HEK-hOAT3 was significantly higher in the Cl(-)-containing medium than the gluconate-containing medium, suggesting that the influences of Cl(-) are not dependent on substrate and that Cl(-) directly stimulates the functions of hOAT1 and hOAT3. gluconic acid 138-147 solute carrier family 22 member 8 Homo sapiens 67-72 19071317-4 2007 In the presence of oxygen, GOx converts glucose to gluconic acid and hydrogen peroxide (H(2)O(2)). gluconic acid 51-64 hydroxyacid oxidase 1 Homo sapiens 27-30 17391039-1 2007 [diagram: see text] Using a boronic acid receptor that was previously found to have high affinity for gluconic acid, we created a colorimetric indicator displacement assay (IDA) that can report the concentration of the product of glucose oxidase (GOx) catalyzed glucose oxidation. gluconic acid 102-115 hydroxyacid oxidase 1 Homo sapiens 230-245 17391039-1 2007 [diagram: see text] Using a boronic acid receptor that was previously found to have high affinity for gluconic acid, we created a colorimetric indicator displacement assay (IDA) that can report the concentration of the product of glucose oxidase (GOx) catalyzed glucose oxidation. gluconic acid 102-115 hydroxyacid oxidase 1 Homo sapiens 247-250 17317744-7 2007 The conductance has an anion-permeability sequence: NO3- approximately I- > NO2- > Br- > Cl- > SO4(2-) approximately HCO3- approximately gluconate- approximately aspartate- approximately cyclamate-. gluconic acid 149-158 NBL1, DAN family BMP antagonist Homo sapiens 52-55 17251326-6 2007 Osmotic shock (addition of 400 mM sucrose), Cl(-) removal (replacement with gluconate), or energy depletion (removal of glucose) led to significantly stronger annexin binding in AE1(-/-) erythrocytes/reticulocytes than in AE1(+/+) erythrocytes. gluconic acid 76-85 annexin A11, opposite strand Mus musculus 159-166 17251326-6 2007 Osmotic shock (addition of 400 mM sucrose), Cl(-) removal (replacement with gluconate), or energy depletion (removal of glucose) led to significantly stronger annexin binding in AE1(-/-) erythrocytes/reticulocytes than in AE1(+/+) erythrocytes. gluconic acid 76-85 solute carrier family 4 (anion exchanger), member 1 Mus musculus 178-181 17975305-7 2007 Anandamide further enhanced the stimulating effects of hypertonic (addition of 550 mM sucrose) or isotonic (isosmotic replacement of Cl- with gluconate) cell shrinkage on annexin V binding. gluconic acid 142-151 annexin A5 Homo sapiens 171-180 17121853-6 2007 Here we present the three-dimensional structure of Gal80p from Kluyveromyces lactis and show that it is structurally homologous to glucose-fructose oxidoreductase, an enzyme in the sorbitol-gluconate pathway. gluconic acid 190-199 transcription regulator GAL80 Saccharomyces cerevisiae S288C 51-57 16048901-9 2005 Kinetic characterization of KCC3a in X. laevis oocytes reveals apparent K(m)s for Rb(+) and Cl(-) of 10.7 +/- 2.5 and 7.3 +/- 1.2 mM, respectively, with an anion selectivity of Br(-) > Cl(-) > PO(4) = I(-) = SCN(-) = gluconate. gluconic acid 223-232 solute carrier family 12 member 6 L homeolog Xenopus laevis 28-33 16871926-3 2006 Biochemical evidence from several studies suggests that zinc is an effective cold treatment and that over-the-counter (OTC) zinc-gluconate compounds may provide the high pharmacologic doses of zinc needed to act as an effective means of treating and reducing the duration and severity of symptoms of the common cold. gluconic acid 124-138 ornithine transcarbamylase Rattus norvegicus 101-123 16206555-4 2005 In Experiment 1, chick weight gain and tibia ash were significantly increased (P < 0.05) by 1.5 and 3% sodium gluconate (NaGlu), 1.5% calcium gluconate (CaGlu), 1.5 and 3% glucono-delta-lactone, and 1% 2-hydroxy-4-methylthio butanoic acid (Alimet). gluconic acid 106-122 N-acetylglucosaminidase, alpha Gallus gallus 124-129 16339930-5 2005 However, addition of gluconate to the growth medium of 39006 repressed transcription of pigA-O, via a PigT-dependent mechanism, resulting in a decrease in Pig production. gluconic acid 21-30 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 88-92 16301672-3 2005 In Bac1 murine macrophages, substitution of extracellular Cl- with gluconate produced a 10-fold increase in the rate and extent of ATP-induced IL-1beta processing and secretion, while reducing the EC50 for ATP by 5-fold. gluconic acid 67-76 interleukin 1 beta Mus musculus 143-151 16301672-4 2005 Replacement of Cl- with gluconate also increased the potency of ATP as an inducer of mature IL-1beta secretion in primary mouse bone marrow-derived macrophages and in THP-1 human monocytes/macrophages. gluconic acid 24-33 interleukin 1 beta Mus musculus 92-100