PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7077053-1	1982	Five reference laboratories were established in Pakistan for monitoring cholinesterase (ChE) activities of workers exposed to organophosphorus compounds.	Organophosphorus Compounds	126-152	butyrylcholinesterase	Homo sapiens	72-86
7077053-1	1982	Five reference laboratories were established in Pakistan for monitoring cholinesterase (ChE) activities of workers exposed to organophosphorus compounds.	Organophosphorus Compounds	126-152	butyrylcholinesterase	Homo sapiens	88-91
614823-0	1977	[Blood cholinesterase activity in agricultural workers exposed to organophosphorus compounds].	Organophosphorus Compounds	66-92	butyrylcholinesterase	Homo sapiens	7-21
4677141-3	1972	The effect of temperature and pH was studied on the kinetics of inhibition of horse serum and human serum cholinesterase by four organophosphorus compounds and five carbamates.	Organophosphorus Compounds	129-155	butyrylcholinesterase	Homo sapiens	106-120
31325422-0	2019	Dimerization of human butyrylcholinesterase expressed in bacterium for development of a thermally stable bioscavenger of organophosphorus compounds.	Organophosphorus Compounds	121-147	butyrylcholinesterase	Homo sapiens	22-43
5315349-0	1971	Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors.	Organophosphorus Compounds	39-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	88-108
33592259-1	2021	Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-113
33592259-1	2021	Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
33592259-1	2021	Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system.	Organophosphorus Compounds	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-113
33592259-1	2021	Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system.	Organophosphorus Compounds	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
33592259-6	2021	BChE is stoichiometrically inhibited by OPs with no apparent toxic result.	Organophosphorus Compounds	40-43	butyrylcholinesterase	Homo sapiens	0-4
33049692-4	2021	PON1 has a limited hydrolytic potential of the racemic OPs, while the bacterial PTE exhibits a significant catalytic activity on the less toxic isomers P(+) of the nerve agents.	Organophosphorus Compounds	55-58	paraoxonase 1	Homo sapiens	0-4
33049692-5	2021	Avian serum albumin also shows a hydrolyzing capacity of chiral OPs with oxo and thio forms.	Organophosphorus Compounds	64-67	albumin	Homo sapiens	6-19
32333945-2	2020	Poisonings by organophosphorus compounds (OP) that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE.	Organophosphorus Compounds	14-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	215-219
28737687-0	2017	New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds.	Organophosphorus Compounds	109-135	butyrylcholinesterase	Homo sapiens	74-95
31138650-2	2019	OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine.	Organophosphorus Compounds	0-3	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-35
31138650-2	2019	OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine.	Organophosphorus Compounds	0-3	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-41
31293901-3	2019	The susceptibility to exposure can be evaluated by studying the most common polymorphisms of genes involved in the metabolism of organophosphorus compounds (cytochrome P450, glutathione transferase, acetyltransferases or paraoxonase 1).	Organophosphorus Compounds	129-155	paraoxonase 1	Homo sapiens	221-234
30458057-1	2019	Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes.	Organophosphorus Compounds	118-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
30458057-1	2019	Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes.	Organophosphorus Compounds	118-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
30458057-1	2019	Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes.	Organophosphorus Compounds	146-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
30458057-1	2019	Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes.	Organophosphorus Compounds	146-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
30027640-2	2019	Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-69
30027640-2	2019	Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75
29024789-1	2018	The primary toxic mechanism of organophosphorus compounds, i.e. nerve agents or pesticides, is based on the irreversible inhibition of acetylcholinesterase.	Organophosphorus Compounds	31-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-155
29180286-1	2018	Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP).	Organophosphorus Compounds	199-225	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
29180286-1	2018	Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP).	Organophosphorus Compounds	199-225	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
29248576-1	2018	Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP).	Organophosphorus Compounds	191-217	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-47
29248576-1	2018	Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP).	Organophosphorus Compounds	191-217	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-53
29986514-1	2018	The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents.	Organophosphorus Compounds	178-204	paraoxonase 1	Homo sapiens	68-81
29986514-1	2018	The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents.	Organophosphorus Compounds	178-204	paraoxonase 1	Homo sapiens	83-87
30950246-1	2019	Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE).	Organophosphorus Compounds	24-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-157
30950246-1	2019	Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE).	Organophosphorus Compounds	24-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-163
30950246-1	2019	Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE).	Organophosphorus Compounds	52-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-157
30950246-1	2019	Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE).	Organophosphorus Compounds	52-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-163
30938485-3	2019	3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds.	Organophosphorus Compounds	241-267	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-165
30938485-3	2019	3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds.	Organophosphorus Compounds	241-267	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-171
30027640-2	2019	Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard.	Organophosphorus Compounds	28-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-69
30027640-2	2019	Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard.	Organophosphorus Compounds	28-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75
30312685-1	2018	Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans.	Organophosphorus Compounds	13-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-114
30312685-1	2018	Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans.	Organophosphorus Compounds	13-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
30176330-0	2018	Cholinesterase and phenyl valerate-esterase activities sensitive to organophosphorus compounds in membranes of chicken brain.	Organophosphorus Compounds	68-94	butyrylcholinesterase	Gallus gallus	0-14
29772260-1	2018	The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents.	Organophosphorus Compounds	119-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-98
29772260-1	2018	The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents.	Organophosphorus Compounds	119-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-104
27939611-1	2017	Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth.	Organophosphorus Compounds	5-31	patatin like phospholipase domain containing 6	Homo sapiens	182-208
28223025-3	2017	Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs).	Organophosphorus Compounds	71-97	paraoxonase 1	Homo sapiens	14-18
28223025-3	2017	Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs).	Organophosphorus Compounds	99-102	paraoxonase 1	Homo sapiens	14-18
28168550-6	2017	In the case of nonchlorinated OPs, by-product formation of HCN, H2S, or PH3 in HTC was observed but did not affect the dynamic range of reproducible isotope values above the limit of detection.	Organophosphorus Compounds	30-33	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	59-62
27939611-1	2017	Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth.	Organophosphorus Compounds	5-31	patatin like phospholipase domain containing 6	Homo sapiens	210-213
27939611-1	2017	Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth.	Organophosphorus Compounds	33-36	patatin like phospholipase domain containing 6	Homo sapiens	182-208
27939611-1	2017	Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth.	Organophosphorus Compounds	33-36	patatin like phospholipase domain containing 6	Homo sapiens	210-213
26948828-2	2017	PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs) such as methyl parathion and chlorpyrifos.	Organophosphorus Compounds	57-83	paraoxonase 1	Homo sapiens	0-4
26948828-2	2017	PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs) such as methyl parathion and chlorpyrifos.	Organophosphorus Compounds	85-88	paraoxonase 1	Homo sapiens	0-4
25522658-1	2015	Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE).	Organophosphorus Compounds	13-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-149
27475862-2	2016	NTE was initially discovered as a target of the so-called organophosphorus-induced delayed polyneuropathy triggered by the inhibition of the NTE-associated esterase center by neuropathic organophosphorus compounds (OPs).	Organophosphorus Compounds	187-213	patatin like phospholipase domain containing 6	Homo sapiens	0-3
27475862-2	2016	NTE was initially discovered as a target of the so-called organophosphorus-induced delayed polyneuropathy triggered by the inhibition of the NTE-associated esterase center by neuropathic organophosphorus compounds (OPs).	Organophosphorus Compounds	187-213	patatin like phospholipase domain containing 6	Homo sapiens	141-144
27475862-2	2016	NTE was initially discovered as a target of the so-called organophosphorus-induced delayed polyneuropathy triggered by the inhibition of the NTE-associated esterase center by neuropathic organophosphorus compounds (OPs).	Organophosphorus Compounds	215-218	patatin like phospholipase domain containing 6	Homo sapiens	0-3
27475862-2	2016	NTE was initially discovered as a target of the so-called organophosphorus-induced delayed polyneuropathy triggered by the inhibition of the NTE-associated esterase center by neuropathic organophosphorus compounds (OPs).	Organophosphorus Compounds	215-218	patatin like phospholipase domain containing 6	Homo sapiens	141-144
27492594-1	2016	Human butyrylcholinesterase is a serine hydrolase that reacts with organophosphorus compounds (OP) to form stable adducts.	Organophosphorus Compounds	67-93	butyrylcholinesterase	Homo sapiens	6-27
25743373-1	2016	The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond.	Organophosphorus Compounds	127-153	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
25743373-1	2016	The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond.	Organophosphorus Compounds	155-158	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
25743373-1	2016	The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond.	Organophosphorus Compounds	155-158	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
27348899-2	2016	Recent studies have shown that organophosphorus compounds increase cyclooxygenase-2 (COX-2) expression and induce neurotoxicity.	Organophosphorus Compounds	31-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	67-83
27348899-2	2016	Recent studies have shown that organophosphorus compounds increase cyclooxygenase-2 (COX-2) expression and induce neurotoxicity.	Organophosphorus Compounds	31-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	85-90
25828536-2	2015	Similar to acetylcholinesterase, the enzyme reacts with organophosphorus compounds (OP) like nerve agents or pesticides that cause enzyme inhibition (BChE adducts).	Organophosphorus Compounds	56-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	11-31
25828536-2	2015	Similar to acetylcholinesterase, the enzyme reacts with organophosphorus compounds (OP) like nerve agents or pesticides that cause enzyme inhibition (BChE adducts).	Organophosphorus Compounds	56-82	butyrylcholinesterase	Homo sapiens	150-154
26851641-1	2016	Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE).	Organophosphorus Compounds	33-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-198
26851641-1	2016	Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE).	Organophosphorus Compounds	33-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	200-204
25743373-1	2016	The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond.	Organophosphorus Compounds	127-153	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
26210933-1	2016	The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP).	Organophosphorus Compounds	188-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-167
26210933-1	2016	The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP).	Organophosphorus Compounds	188-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173
23625910-3	2015	The aim of this study was to determine the effects of PON1 gene polymorphism and its effects on PON and AChE enzyme activities in individuals who were exposed to organophosphorus insecticides due to occupational reasons, and to profile the probability of susceptibility to organophosphorus compounds.	Organophosphorus Compounds	273-299	paraoxonase 1	Homo sapiens	54-58
23625910-3	2015	The aim of this study was to determine the effects of PON1 gene polymorphism and its effects on PON and AChE enzyme activities in individuals who were exposed to organophosphorus insecticides due to occupational reasons, and to profile the probability of susceptibility to organophosphorus compounds.	Organophosphorus Compounds	273-299	paraoxonase 1	Homo sapiens	54-57
24912784-1	2015	Organophosphorus compounds (OP) are bound to human butyrylcholinesterase (BChE) and endogenous or exogenous BChE may act as a stoichiometric scavenger.	Organophosphorus Compounds	0-26	butyrylcholinesterase	Homo sapiens	51-72
24912784-1	2015	Organophosphorus compounds (OP) are bound to human butyrylcholinesterase (BChE) and endogenous or exogenous BChE may act as a stoichiometric scavenger.	Organophosphorus Compounds	0-26	butyrylcholinesterase	Homo sapiens	74-78
24912784-1	2015	Organophosphorus compounds (OP) are bound to human butyrylcholinesterase (BChE) and endogenous or exogenous BChE may act as a stoichiometric scavenger.	Organophosphorus Compounds	0-26	butyrylcholinesterase	Homo sapiens	108-112
25522658-1	2015	Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE).	Organophosphorus Compounds	13-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
25255935-1	2014	Neuropathy target esterase (NTE) is a protein involved in the development of a polyneuropathy caused by exposure to certain organophosphorus compounds.	Organophosphorus Compounds	124-150	patatin like phospholipase domain containing 6	Homo sapiens	0-26
25255935-1	2014	Neuropathy target esterase (NTE) is a protein involved in the development of a polyneuropathy caused by exposure to certain organophosphorus compounds.	Organophosphorus Compounds	124-150	patatin like phospholipase domain containing 6	Homo sapiens	28-31
24136594-2	2014	OPC-induced mortality can be significantly reduced by prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors.	Organophosphorus Compounds	0-3	acetylcholinesterase	Rattus norvegicus	96-116
24576786-1	2014	Organophosphorus compounds (OPs) induce neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Gallus gallus	149-175
24576786-1	2014	Organophosphorus compounds (OPs) induce neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Gallus gallus	177-180
24576786-1	2014	Organophosphorus compounds (OPs) induce neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Gallus gallus	149-175
24576786-1	2014	Organophosphorus compounds (OPs) induce neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Gallus gallus	177-180
24136594-2	2014	OPC-induced mortality can be significantly reduced by prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors.	Organophosphorus Compounds	0-3	acetylcholinesterase	Rattus norvegicus	118-122
24142151-3	2014	NTE-related motor neuron disease is associated with the expression of a mutant form of NTE and the inhibition and further modification of NTE by organophosphorus compounds is the trigger of a delayed neurodegenerative neuropathy.	Organophosphorus Compounds	145-171	patatin-like phospholipase domain containing 6	Mus musculus	0-3
25050413-3	2014	The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs).	Organophosphorus Compounds	250-276	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
25050413-3	2014	The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs).	Organophosphorus Compounds	250-276	acetylcholinesterase (Cartwright blood group)	Homo sapiens	220-224
25050413-3	2014	The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs).	Organophosphorus Compounds	278-281	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
25050413-3	2014	The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs).	Organophosphorus Compounds	278-281	acetylcholinesterase (Cartwright blood group)	Homo sapiens	220-224
24142151-3	2014	NTE-related motor neuron disease is associated with the expression of a mutant form of NTE and the inhibition and further modification of NTE by organophosphorus compounds is the trigger of a delayed neurodegenerative neuropathy.	Organophosphorus Compounds	145-171	patatin-like phospholipase domain containing 6	Mus musculus	87-90
24142151-3	2014	NTE-related motor neuron disease is associated with the expression of a mutant form of NTE and the inhibition and further modification of NTE by organophosphorus compounds is the trigger of a delayed neurodegenerative neuropathy.	Organophosphorus Compounds	145-171	patatin-like phospholipase domain containing 6	Mus musculus	87-90
24057572-1	2014	Great efforts have been undertaken in the last decades to develop new oximes to reactivate acetylcholinesterase inhibited by organophosphorus compounds (OP).	Organophosphorus Compounds	125-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
23909275-7	2014	This Account discusses the previously neglected potential of these phosphinates as replacements of PCl3 for the preparation of organophosphorus compounds.	Organophosphorus Compounds	127-153	PHD finger protein 19	Homo sapiens	99-103
24649050-1	2013	The toxicity of organophosphorus compounds (OPs) results primarily from the irreversible inhibition of acetylcholinesterase (AChE).	Organophosphorus Compounds	16-42	acetylcholinesterase	Mus musculus	103-123
24413757-3	2014	Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
24413757-3	2014	Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited.	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Homo sapiens	168-194
24413757-3	2014	Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited.	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Homo sapiens	196-199
24413757-3	2014	Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited.	Organophosphorus Compounds	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
24413757-3	2014	Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited.	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Homo sapiens	168-194
24413757-3	2014	Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited.	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Homo sapiens	196-199
24649050-1	2013	The toxicity of organophosphorus compounds (OPs) results primarily from the irreversible inhibition of acetylcholinesterase (AChE).	Organophosphorus Compounds	16-42	acetylcholinesterase	Mus musculus	125-129
24649050-1	2013	The toxicity of organophosphorus compounds (OPs) results primarily from the irreversible inhibition of acetylcholinesterase (AChE).	Organophosphorus Compounds	44-47	acetylcholinesterase	Mus musculus	103-123
24649050-1	2013	The toxicity of organophosphorus compounds (OPs) results primarily from the irreversible inhibition of acetylcholinesterase (AChE).	Organophosphorus Compounds	44-47	acetylcholinesterase	Mus musculus	125-129
23047024-1	2013	Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
23047024-1	2013	Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms.	Organophosphorus Compounds	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
23123251-7	2013	The Hansch model showed that increasing neuropathic potential correlated with rising R hydrophobicity; moreover, OPC binding to scavenger EOHs (BChE and CaE) had different effects on potential acute and delayed neurotoxicity.	Organophosphorus Compounds	113-116	butyrylcholinesterase	Homo sapiens	144-148
23658579-10	2013	CONCLUSION: Organophosphorus compounds inhibit cholinesterase action leading to cholinergic hyperactivity.	Organophosphorus Compounds	12-38	butyrylcholinesterase	Homo sapiens	47-61
23123251-7	2013	The Hansch model showed that increasing neuropathic potential correlated with rising R hydrophobicity; moreover, OPC binding to scavenger EOHs (BChE and CaE) had different effects on potential acute and delayed neurotoxicity.	Organophosphorus Compounds	113-116	gap junction protein alpha 8	Homo sapiens	153-156
23200747-1	2013	Organophosphorus compounds (OPs) cause neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Gallus gallus	148-174
23200747-1	2013	Organophosphorus compounds (OPs) cause neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Gallus gallus	176-179
23200747-1	2013	Organophosphorus compounds (OPs) cause neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Gallus gallus	148-174
23200747-1	2013	Organophosphorus compounds (OPs) cause neurotoxic disorders through interactions with well-known target esterases, such as acetylcholinesterase and neuropathy target esterase (NTE).	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Gallus gallus	176-179
23220589-5	2013	The difficulties in reactivation of ChE activity and slight antidote effect regarding intoxication with some OPC are some of the reasons for continuous efforts to obtain new reactivators of ChE.	Organophosphorus Compounds	109-112	butyrylcholinesterase	Rattus norvegicus	190-193
21856330-4	2011	The biosensor was based on inhibition of AChE by OP compounds/insecticides.	Organophosphorus Compounds	49-61	acetylcholinesterase	Rattus norvegicus	41-45
23201180-2	2013	The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs).	Organophosphorus Compounds	128-154	paraoxonase 1	Homo sapiens	4-17
23201180-2	2013	The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs).	Organophosphorus Compounds	128-154	paraoxonase 1	Homo sapiens	36-40
23201180-2	2013	The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs).	Organophosphorus Compounds	156-159	paraoxonase 1	Homo sapiens	4-17
23201180-2	2013	The paraoxonase 1 from human serum (PON1) is a phosphotriesterase (PTE) that hydrolyses several xenobiotics including drugs and organophosphorus compounds (OPs).	Organophosphorus Compounds	156-159	paraoxonase 1	Homo sapiens	36-40
23244429-1	2012	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors can protect against the lethal effects of organophosphorus compounds (OPCs).	Organophosphorus Compounds	123-149	acetylcholinesterase	Rattus norvegicus	42-62
23244429-1	2012	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors can protect against the lethal effects of organophosphorus compounds (OPCs).	Organophosphorus Compounds	123-149	acetylcholinesterase	Rattus norvegicus	64-68
23158570-1	2012	OBJECTIVE: To explore the protective effects of intranasal (IN) dosing of nerve growth factor (NGF) on brain injury induced by organophosphorus compounds (OP) in rats.	Organophosphorus Compounds	127-153	nerve growth factor	Rattus norvegicus	74-93
23158570-1	2012	OBJECTIVE: To explore the protective effects of intranasal (IN) dosing of nerve growth factor (NGF) on brain injury induced by organophosphorus compounds (OP) in rats.	Organophosphorus Compounds	127-153	nerve growth factor	Rattus norvegicus	95-98
22561105-1	2012	Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment.	Organophosphorus Compounds	73-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
22561105-1	2012	Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment.	Organophosphorus Compounds	73-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
21953823-1	2012	Pralidoxime (2-PAM) belongs to the class of monopyridinium oximes with reactivating potency on cholinesterases inhibited by phosphylating organophosphorus compounds (OPC), for example, pesticides and nerve agents.	Organophosphorus Compounds	138-164	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	15-18
21953823-1	2012	Pralidoxime (2-PAM) belongs to the class of monopyridinium oximes with reactivating potency on cholinesterases inhibited by phosphylating organophosphorus compounds (OPC), for example, pesticides and nerve agents.	Organophosphorus Compounds	166-169	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	15-18
21998030-1	2012	Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach.	Organophosphorus Compounds	77-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
21998030-1	2012	Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach.	Organophosphorus Compounds	77-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
20807085-1	2011	The standard treatment of poisoning by organophosphorus compounds (OP) includes the reversible muscarine receptor antagonist atropine and oximes for the reactivation of OP-inhibited acetylcholinesterase (AChE).	Organophosphorus Compounds	39-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	204-208
21930118-1	2011	Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides.	Organophosphorus Compounds	39-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-112
21763810-3	2011	The biosensor was based on inhibition of AChE by OP compounds/insecticides.	Organophosphorus Compounds	49-61	GDSL esterase/lipase ACHE	Zea mays	41-45
21470076-1	2011	For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial.	Organophosphorus Compounds	63-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-132
21470076-1	2011	For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial.	Organophosphorus Compounds	63-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
20981864-1	2011	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality.	Organophosphorus Compounds	128-131	acetylcholinesterase	Rattus norvegicus	64-68
20981864-1	2011	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality.	Organophosphorus Compounds	100-126	acetylcholinesterase	Rattus norvegicus	42-62
20981864-1	2011	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality.	Organophosphorus Compounds	100-126	acetylcholinesterase	Rattus norvegicus	64-68
20981864-1	2011	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality.	Organophosphorus Compounds	128-132	acetylcholinesterase	Rattus norvegicus	42-62
20981864-1	2011	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality.	Organophosphorus Compounds	128-132	acetylcholinesterase	Rattus norvegicus	64-68
20981864-1	2011	Prophylactic administration of reversible acetylcholinesterase (AChE) inhibitors before exposure to organophosphorus compounds (OPCs) can reduce OPC-induced mortality.	Organophosphorus Compounds	128-131	acetylcholinesterase	Rattus norvegicus	42-62
20882513-1	2010	Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue.	Organophosphorus Compounds	15-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
20669006-1	2011	Acetylcholinesterase (AChE) is the primary target of organophosphorus compounds (OP).	Organophosphorus Compounds	53-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
20669006-1	2011	Acetylcholinesterase (AChE) is the primary target of organophosphorus compounds (OP).	Organophosphorus Compounds	53-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
21828920-1	2011	Yeast cells displaying organophosphorus hydrolase (OPH), which was anchored using a lectin-like cell-wall protein (Flo1p), were used as a biocatalyst for the detection of organophosphorus compounds (OPs).	Organophosphorus Compounds	171-197	flocculin FLO1	Saccharomyces cerevisiae S288C	115-120
21828920-1	2011	Yeast cells displaying organophosphorus hydrolase (OPH), which was anchored using a lectin-like cell-wall protein (Flo1p), were used as a biocatalyst for the detection of organophosphorus compounds (OPs).	Organophosphorus Compounds	199-202	flocculin FLO1	Saccharomyces cerevisiae S288C	115-120
21144749-2	2011	They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds.	Organophosphorus Compounds	125-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-43
21144749-2	2011	They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds.	Organophosphorus Compounds	125-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
21144749-2	2011	They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds.	Organophosphorus Compounds	125-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
21451868-1	2011	Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE).	Organophosphorus Compounds	30-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-116
21451868-1	2011	Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE).	Organophosphorus Compounds	30-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122
20882513-1	2010	Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue.	Organophosphorus Compounds	15-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-129
20156534-1	2010	Standard treatment of acute poisoning by organophosphorus compounds (OP) includes administration of an antimuscarinic (e.g. atropine) and of an oxime-based reactivator of OP-inhibited acetylcholinesterase (AChE).	Organophosphorus Compounds	41-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	206-210
20542100-1	2010	OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs).	Organophosphorus Compounds	119-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-58
20542100-1	2010	OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs).	Organophosphorus Compounds	119-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
20542100-1	2010	OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs).	Organophosphorus Compounds	147-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-58
20542100-1	2010	OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs).	Organophosphorus Compounds	147-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64
20188121-1	2010	Single doses of organophosphorus compounds (OP) which covalently inhibit neuropathy target esterase (NTE) can induce lower-limb paralysis and distal damage in long nerve axons.	Organophosphorus Compounds	16-42	patatin-like phospholipase domain containing 6	Mus musculus	73-99
20188121-1	2010	Single doses of organophosphorus compounds (OP) which covalently inhibit neuropathy target esterase (NTE) can induce lower-limb paralysis and distal damage in long nerve axons.	Organophosphorus Compounds	16-42	patatin-like phospholipase domain containing 6	Mus musculus	101-104
19883634-1	2010	It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling.	Organophosphorus Compounds	116-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
19883634-1	2010	It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling.	Organophosphorus Compounds	116-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
20206154-1	2010	Butyrylcholinesterase is considered to be an endogenous stoichiometric bioscavenger of organophosphorus compounds (OPs), but due to limited concentration of BChE in the organism, stoichiometric reduction of OP is not always sufficient.	Organophosphorus Compounds	87-113	butyrylcholinesterase	Homo sapiens	0-21
20206154-1	2010	Butyrylcholinesterase is considered to be an endogenous stoichiometric bioscavenger of organophosphorus compounds (OPs), but due to limited concentration of BChE in the organism, stoichiometric reduction of OP is not always sufficient.	Organophosphorus Compounds	115-118	butyrylcholinesterase	Homo sapiens	0-21
20338154-4	2010	Native, untagged engineered recombinant human PON1 (rHuPON1) expressed in Escherichia coli and purified by conventional column chromatographic purification is stable, active, and capable of protecting PON1 knockout mice (PON1(-/-)) from exposure to high levels of the OP compound diazoxon.	Organophosphorus Compounds	268-279	paraoxonase 1	Homo sapiens	46-50
20338154-4	2010	Native, untagged engineered recombinant human PON1 (rHuPON1) expressed in Escherichia coli and purified by conventional column chromatographic purification is stable, active, and capable of protecting PON1 knockout mice (PON1(-/-)) from exposure to high levels of the OP compound diazoxon.	Organophosphorus Compounds	268-279	paraoxonase 1	Homo sapiens	55-59
20338154-4	2010	Native, untagged engineered recombinant human PON1 (rHuPON1) expressed in Escherichia coli and purified by conventional column chromatographic purification is stable, active, and capable of protecting PON1 knockout mice (PON1(-/-)) from exposure to high levels of the OP compound diazoxon.	Organophosphorus Compounds	268-279	paraoxonase 1	Mus musculus	55-59
20095398-1	2009	Experiments on Wistar rats showed that subacute poisoning by organophosphorus compounds dimethyldichlorovinyl phosphate (DDVF), malation, and dimethylparation (total dose, 1.0 LD50) suppresses both cell and humoral immune responses and significantly decreases the level of blood cytokines (IFNg, IL-4) and the IFNg/IL-4 ratio in comparison to the control, which is evidence for a greater lesion of Th1 cells in comparison to Th2 cells.	Organophosphorus Compounds	61-87	interferon gamma	Rattus norvegicus	290-294
20097283-1	2010	Organophosphorus-induced delayed polyneuropathy (OPIDP) is a syndrome induced by certain organophosphorus compounds (OPs) through a mechanism based on the inhibition and further modification (aging) of neuropathy target esterase (NTE).	Organophosphorus Compounds	117-120	patatin like phospholipase domain containing 6	Homo sapiens	202-228
20097283-1	2010	Organophosphorus-induced delayed polyneuropathy (OPIDP) is a syndrome induced by certain organophosphorus compounds (OPs) through a mechanism based on the inhibition and further modification (aging) of neuropathy target esterase (NTE).	Organophosphorus Compounds	117-120	patatin like phospholipase domain containing 6	Homo sapiens	230-233
20095398-1	2009	Experiments on Wistar rats showed that subacute poisoning by organophosphorus compounds dimethyldichlorovinyl phosphate (DDVF), malation, and dimethylparation (total dose, 1.0 LD50) suppresses both cell and humoral immune responses and significantly decreases the level of blood cytokines (IFNg, IL-4) and the IFNg/IL-4 ratio in comparison to the control, which is evidence for a greater lesion of Th1 cells in comparison to Th2 cells.	Organophosphorus Compounds	61-87	interleukin 4	Rattus norvegicus	296-300
20095398-1	2009	Experiments on Wistar rats showed that subacute poisoning by organophosphorus compounds dimethyldichlorovinyl phosphate (DDVF), malation, and dimethylparation (total dose, 1.0 LD50) suppresses both cell and humoral immune responses and significantly decreases the level of blood cytokines (IFNg, IL-4) and the IFNg/IL-4 ratio in comparison to the control, which is evidence for a greater lesion of Th1 cells in comparison to Th2 cells.	Organophosphorus Compounds	61-87	interferon gamma	Rattus norvegicus	310-314
20095398-1	2009	Experiments on Wistar rats showed that subacute poisoning by organophosphorus compounds dimethyldichlorovinyl phosphate (DDVF), malation, and dimethylparation (total dose, 1.0 LD50) suppresses both cell and humoral immune responses and significantly decreases the level of blood cytokines (IFNg, IL-4) and the IFNg/IL-4 ratio in comparison to the control, which is evidence for a greater lesion of Th1 cells in comparison to Th2 cells.	Organophosphorus Compounds	61-87	interleukin 4	Rattus norvegicus	315-319
19778238-1	2009	Organophosphorus compounds (OPs) are potent inhibitors of acetylcholinesterase (AChE).	Organophosphorus Compounds	0-26	acetylcholinesterase	Cavia porcellus	58-78
19778238-1	2009	Organophosphorus compounds (OPs) are potent inhibitors of acetylcholinesterase (AChE).	Organophosphorus Compounds	0-26	acetylcholinesterase	Cavia porcellus	80-84
19778238-1	2009	Organophosphorus compounds (OPs) are potent inhibitors of acetylcholinesterase (AChE).	Organophosphorus Compounds	28-31	acetylcholinesterase	Cavia porcellus	58-78
19778238-1	2009	Organophosphorus compounds (OPs) are potent inhibitors of acetylcholinesterase (AChE).	Organophosphorus Compounds	28-31	acetylcholinesterase	Cavia porcellus	80-84
19526299-1	2009	Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs).	Organophosphorus Compounds	216-242	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-170
19603416-1	2009	K-oximes have recently been developed in the search for efficacious broad-band reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OPC).	Organophosphorus Compounds	136-162	acetylcholinesterase	Rattus norvegicus	95-115
19603416-1	2009	K-oximes have recently been developed in the search for efficacious broad-band reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OPC).	Organophosphorus Compounds	136-162	acetylcholinesterase	Rattus norvegicus	117-121
19603416-1	2009	K-oximes have recently been developed in the search for efficacious broad-band reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OPC).	Organophosphorus Compounds	164-167	acetylcholinesterase	Rattus norvegicus	95-115
19603416-1	2009	K-oximes have recently been developed in the search for efficacious broad-band reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OPC).	Organophosphorus Compounds	164-167	acetylcholinesterase	Rattus norvegicus	117-121
19526299-1	2009	Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs).	Organophosphorus Compounds	216-242	acetylcholinesterase (Cartwright blood group)	Homo sapiens	172-176
19526299-1	2009	Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs).	Organophosphorus Compounds	244-248	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-170
19526299-1	2009	Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs).	Organophosphorus Compounds	244-248	acetylcholinesterase (Cartwright blood group)	Homo sapiens	172-176
18603232-1	2008	The therapeutic value of human serum butyrylcholinesterase (Hu BChE) as a bioscavenger of chemical warfare agents is due to its high reactivity with organophosphorus compounds and prolonged circulatory stability.	Organophosphorus Compounds	149-175	butyrylcholinesterase	Homo sapiens	37-58
19426854-6	2009	Applications using prolidase to detoxify OP nerve agents include its incorporation into fire-fighting foams and as biosensors for OP compound detection.	Organophosphorus Compounds	130-141	peptidase D	Homo sapiens	19-28
18603232-1	2008	The therapeutic value of human serum butyrylcholinesterase (Hu BChE) as a bioscavenger of chemical warfare agents is due to its high reactivity with organophosphorus compounds and prolonged circulatory stability.	Organophosphorus Compounds	149-175	butyrylcholinesterase	Homo sapiens	63-67
12907237-1	2003	The inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	49-75	acetylcholinesterase	Mus musculus	18-38
18597495-1	2008	Human serum albumin was able to hydrolyze the organophosphorus compounds paraoxon, chlorpyrifos-oxon, and diazoxon at toxicologically relevant concentrations.	Organophosphorus Compounds	46-72	albumin	Mus musculus	12-19
17532308-1	2007	Paraoxonase (PON1) plays an important role in mechanism of organophosphorus compound (OP) toxicity, as seen both in vitro and in vivo studies.	Organophosphorus Compounds	59-84	paraoxonase 1	Homo sapiens	0-11
17532308-1	2007	Paraoxonase (PON1) plays an important role in mechanism of organophosphorus compound (OP) toxicity, as seen both in vitro and in vivo studies.	Organophosphorus Compounds	59-84	paraoxonase 1	Homo sapiens	13-17
17456837-2	2007	Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-121
17456837-2	2007	Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition.	Organophosphorus Compounds	0-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-127
16963094-1	2007	Organophosphorus compounds (OP) such as phenyl saligenin phosphate (PSP) and mipafox (MPX) which cause delayed neuropathy, inhibit neuropathy target esterase (NTE), while OPs such as paraoxon (PXN) react more readily with acetylcholinesterase.	Organophosphorus Compounds	0-26	patatin-like phospholipase domain containing 6	Mus musculus	131-157
16963094-1	2007	Organophosphorus compounds (OP) such as phenyl saligenin phosphate (PSP) and mipafox (MPX) which cause delayed neuropathy, inhibit neuropathy target esterase (NTE), while OPs such as paraoxon (PXN) react more readily with acetylcholinesterase.	Organophosphorus Compounds	0-26	patatin-like phospholipase domain containing 6	Mus musculus	159-162
17936934-0	2007	Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.	Organophosphorus Compounds	92-118	paraoxonase 1	Mus musculus	43-56
17936934-0	2007	Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.	Organophosphorus Compounds	92-118	paraoxonase 1	Mus musculus	58-62
16942853-1	2006	Tenocyclidine-TCP showing a broad spectrum of pharmacological activity including antidotal effect in organophosphorus compounds poisoning, radioprotective and anticancer effects.	Organophosphorus Compounds	101-127	serine peptidase inhibitor Kazal type 1	Homo sapiens	14-17
16770629-0	2006	Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?	Organophosphorus Compounds	65-91	acetylcholinesterase	Rattus norvegicus	0-20
16876764-1	2006	Inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) such as pesticides and nerve agents causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	45-71	acetylcholinesterase	Mus musculus	14-34
16876764-1	2006	Inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) such as pesticides and nerve agents causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	45-71	acetylcholinesterase	Mus musculus	36-40
16876764-1	2006	Inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) such as pesticides and nerve agents causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	73-76	acetylcholinesterase	Mus musculus	14-34
16876764-1	2006	Inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) such as pesticides and nerve agents causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	73-76	acetylcholinesterase	Mus musculus	36-40
16479322-3	2006	Recently, the FDA approved, based on animal experiments, for military combat medical use oral pyridostigmine (PSTG) for pre-exposure treatment of soman; the concept is to block the cholinesterase reversibly using the carbamate pyridostigmine in order to deny access to the active site of the enzyme to the irreversible inhibitor (OPC) on subsequent exposure.	Organophosphorus Compounds	330-333	butyrylcholinesterase	Rattus norvegicus	181-195
16515465-1	2006	Nerve agents (sarin, soman, cyclosarin, tabun and VX agent) and pesticides (paraoxon, chlorpyrifos, TEPP) represent extremely toxic group of organophosphorus compounds (OPCs).	Organophosphorus Compounds	141-167	testis, prostate and placenta expressed	Homo sapiens	100-104
16515465-1	2006	Nerve agents (sarin, soman, cyclosarin, tabun and VX agent) and pesticides (paraoxon, chlorpyrifos, TEPP) represent extremely toxic group of organophosphorus compounds (OPCs).	Organophosphorus Compounds	169-173	testis, prostate and placenta expressed	Homo sapiens	100-104
16388582-1	2006	Organophosphorus compounds (OPs) interfere with the catalytic mechanism of acetylcholinesterase (AChE) by rapidly phosphorylating the catalytic serine residue.	Organophosphorus Compounds	0-26	acetylcholinesterase	Mus musculus	75-95
16388582-1	2006	Organophosphorus compounds (OPs) interfere with the catalytic mechanism of acetylcholinesterase (AChE) by rapidly phosphorylating the catalytic serine residue.	Organophosphorus Compounds	0-26	acetylcholinesterase	Mus musculus	97-101
16388582-1	2006	Organophosphorus compounds (OPs) interfere with the catalytic mechanism of acetylcholinesterase (AChE) by rapidly phosphorylating the catalytic serine residue.	Organophosphorus Compounds	28-31	acetylcholinesterase	Mus musculus	75-95
16388582-1	2006	Organophosphorus compounds (OPs) interfere with the catalytic mechanism of acetylcholinesterase (AChE) by rapidly phosphorylating the catalytic serine residue.	Organophosphorus Compounds	28-31	acetylcholinesterase	Mus musculus	97-101
16293236-1	2005	Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE.	Organophosphorus Compounds	22-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	158-178
16293236-1	2005	Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE.	Organophosphorus Compounds	22-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	180-184
16293236-1	2005	Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE.	Organophosphorus Compounds	22-48	CHE	Capra hircus	4-5
16293236-1	2005	Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE.	Organophosphorus Compounds	22-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	416-420
16007003-1	2005	OBJECTIVES: The Q192R polymorphism of paraoxonase (PON1) has been shown to affect hydrolysis of organophosphorus compounds.	Organophosphorus Compounds	96-122	paraoxonase 1	Homo sapiens	38-49
16007003-1	2005	OBJECTIVES: The Q192R polymorphism of paraoxonase (PON1) has been shown to affect hydrolysis of organophosphorus compounds.	Organophosphorus Compounds	96-122	paraoxonase 1	Mus musculus	51-55
16119193-1	2005	Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially with pesticides or nerve agents.	Organophosphorus Compounds	90-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36
16119193-1	2005	Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially with pesticides or nerve agents.	Organophosphorus Compounds	90-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
15762562-3	2005	The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species.	Organophosphorus Compounds	102-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-81
15762562-3	2005	The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species.	Organophosphorus Compounds	102-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
15035642-1	2004	Aging of organophosphorus (OP)-compound-inhibited neuropathy target esterase (NTE) is the critical event that initiates OP-compound-induced delayed neurotoxicity (OPIDN).	Organophosphorus Compounds	120-131	patatin like phospholipase domain containing 6	Homo sapiens	50-76
15035642-1	2004	Aging of organophosphorus (OP)-compound-inhibited neuropathy target esterase (NTE) is the critical event that initiates OP-compound-induced delayed neurotoxicity (OPIDN).	Organophosphorus Compounds	120-131	patatin like phospholipase domain containing 6	Homo sapiens	78-81
17913691-0	2007	Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds.	Organophosphorus Compounds	140-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	15-35
17913691-1	2007	Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP).	Organophosphorus Compounds	88-114	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
17913691-1	2007	Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP).	Organophosphorus Compounds	88-114	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
17402711-1	2007	Organophosphorus compounds (OPs), such as nerve agents and a group of insecticides, irreversibly inhibit the enzyme acetylcholinesterase (AChE) by a rapid phosphorylation of the catalytic Ser203 residue.	Organophosphorus Compounds	0-26	acetylcholinesterase	Mus musculus	116-136
17402711-1	2007	Organophosphorus compounds (OPs), such as nerve agents and a group of insecticides, irreversibly inhibit the enzyme acetylcholinesterase (AChE) by a rapid phosphorylation of the catalytic Ser203 residue.	Organophosphorus Compounds	0-26	acetylcholinesterase	Mus musculus	138-142
17402711-1	2007	Organophosphorus compounds (OPs), such as nerve agents and a group of insecticides, irreversibly inhibit the enzyme acetylcholinesterase (AChE) by a rapid phosphorylation of the catalytic Ser203 residue.	Organophosphorus Compounds	28-31	acetylcholinesterase	Mus musculus	116-136
17402711-1	2007	Organophosphorus compounds (OPs), such as nerve agents and a group of insecticides, irreversibly inhibit the enzyme acetylcholinesterase (AChE) by a rapid phosphorylation of the catalytic Ser203 residue.	Organophosphorus Compounds	28-31	acetylcholinesterase	Mus musculus	138-142
16780806-0	2006	Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.	Organophosphorus Compounds	141-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-124
16266695-1	2005	Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime).	Organophosphorus Compounds	35-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-163
12907237-1	2003	The inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	49-75	acetylcholinesterase	Mus musculus	40-44
12907237-1	2003	The inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	77-80	acetylcholinesterase	Mus musculus	18-38
12907237-1	2003	The inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) causes acute toxicity or death of the intoxicated individual.	Organophosphorus Compounds	77-80	acetylcholinesterase	Mus musculus	40-44
12777966-1	2003	BACKGROUND: Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids.	Organophosphorus Compounds	97-123	paraoxonase 1	Homo sapiens	12-23
12777966-1	2003	BACKGROUND: Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids.	Organophosphorus Compounds	97-123	paraoxonase 1	Homo sapiens	25-29
12746135-0	2003	Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds.	Organophosphorus Compounds	107-133	patatin like phospholipase domain containing 6	Homo sapiens	23-49
12706567-1	2003	The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water.	Organophosphorus Compounds	128-154	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64
12706567-1	2003	The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water.	Organophosphorus Compounds	128-154	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
9587020-0	1998	Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.	Organophosphorus Compounds	131-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-104
11679273-1	2001	The fiber-optic biosensor consisting of an acetylcholinesterase (AChE)-immobilized Langmuir-Blodgett (LB) film was developed to detect organophosphorus compounds in contaminated water.	Organophosphorus Compounds	135-161	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
11022865-1	2000	It has been assumed since its discovery that serum paraoxonase (PON1) plays a major role in the detoxication of specific organophosphorus compounds.	Organophosphorus Compounds	121-147	paraoxonase 1	Mus musculus	64-68
10421485-0	1999	Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds.	Organophosphorus Compounds	105-131	glucuronidase, beta	Rattus norvegicus	55-73
10421485-3	1999	We investigated the effects of organophosphorus compounds (OPs) such as insecticides on the dissociation of egasyn-beta-glucuronidase (EG) complex.	Organophosphorus Compounds	31-57	carboxylesterase 1E	Rattus norvegicus	108-114
10421485-3	1999	We investigated the effects of organophosphorus compounds (OPs) such as insecticides on the dissociation of egasyn-beta-glucuronidase (EG) complex.	Organophosphorus Compounds	31-57	glucuronidase, beta	Rattus norvegicus	115-133
10421485-3	1999	We investigated the effects of organophosphorus compounds (OPs) such as insecticides on the dissociation of egasyn-beta-glucuronidase (EG) complex.	Organophosphorus Compounds	59-62	carboxylesterase 1E	Rattus norvegicus	108-114
10421485-3	1999	We investigated the effects of organophosphorus compounds (OPs) such as insecticides on the dissociation of egasyn-beta-glucuronidase (EG) complex.	Organophosphorus Compounds	59-62	glucuronidase, beta	Rattus norvegicus	115-133
9268605-0	1997	Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity.	Organophosphorus Compounds	102-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
9268605-0	1997	Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity.	Organophosphorus Compounds	102-128	patatin like phospholipase domain containing 6	Homo sapiens	25-51
9268605-1	1997	The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects.	Organophosphorus Compounds	141-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-72
9268605-1	1997	The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects.	Organophosphorus Compounds	141-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	74-78
9268605-1	1997	The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects.	Organophosphorus Compounds	141-167	patatin like phospholipase domain containing 6	Homo sapiens	84-110
9268605-1	1997	The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects.	Organophosphorus Compounds	141-167	patatin like phospholipase domain containing 6	Homo sapiens	112-115
8246310-1	1993	We studied the ability of 2-PAM to reactivate cholinesterase (ChE) inhibited by organophosphorus compounds (OPs) and aging.	Organophosphorus Compounds	108-111	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	28-31
8930121-2	1996	Some organophosphorus compounds induce a neurodegenarative syndrome related to the covalent modification of a carboxylesterase known as neuropathy target esterase.	Organophosphorus Compounds	5-31	patatin like phospholipase domain containing 6	Bos taurus	136-162
8896566-1	1996	Many organophosphorus compounds (OPs) are potent cholinesterase inhibitors, accounting for their use as insecticides and, unfortunately, also as nerve agents.	Organophosphorus Compounds	5-31	butyrylcholinesterase	Homo sapiens	49-63
8896566-1	1996	Many organophosphorus compounds (OPs) are potent cholinesterase inhibitors, accounting for their use as insecticides and, unfortunately, also as nerve agents.	Organophosphorus Compounds	33-36	butyrylcholinesterase	Homo sapiens	49-63
7983680-3	1994	In the present article, a partial characterization is made of the NTE and other related PV esterases in the bovine adrenal medulla and brain; NTE sensitivity to the neurotoxic organophosphorus compound mipafox is investigated, and its subcellular distribution is studied.	Organophosphorus Compounds	176-201	patatin like phospholipase domain containing 6	Bos taurus	66-69
7983680-3	1994	In the present article, a partial characterization is made of the NTE and other related PV esterases in the bovine adrenal medulla and brain; NTE sensitivity to the neurotoxic organophosphorus compound mipafox is investigated, and its subcellular distribution is studied.	Organophosphorus Compounds	176-201	patatin like phospholipase domain containing 6	Bos taurus	142-145
8344004-1	1993	A short review is presented on the key points in the development of the hypothesis for the initiation of delayed neuropathy by reaction of organophosphorus compounds with neuropathy target esterase (NTE).	Organophosphorus Compounds	139-165	patatin like phospholipase domain containing 6	Homo sapiens	171-197
8374048-0	1993	Carbamates of (hydroxyphenoxy)methyl heteroaromatic salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.	Organophosphorus Compounds	123-149	acetylcholinesterase	Mus musculus	61-81
8374049-0	1993	Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.	Organophosphorus Compounds	127-153	acetylcholinesterase	Mus musculus	65-85
8344004-1	1993	A short review is presented on the key points in the development of the hypothesis for the initiation of delayed neuropathy by reaction of organophosphorus compounds with neuropathy target esterase (NTE).	Organophosphorus Compounds	139-165	patatin like phospholipase domain containing 6	Homo sapiens	199-202
6290952-8	1982	Neurotoxic OP-compounds, that cause secondary degeneration of myelin (Wallerian), may be associated with decreased brain and spinal cord CNP activity at the time of maximal locomotor impairment.	Organophosphorus Compounds	11-23	2',3'-cyclic nucleotide 3' phosphodiesterase	Gallus gallus	137-140
1397476-1	1992	Marked (greater than 70%) reduction of the neuropathy target enzyme (NTE) shortly after exposure to organophosphorus compounds heralds the onset of delayed neuropathic damage in animals and humans.	Organophosphorus Compounds	100-126	patatin like phospholipase domain containing 6	Homo sapiens	43-67
1397476-1	1992	Marked (greater than 70%) reduction of the neuropathy target enzyme (NTE) shortly after exposure to organophosphorus compounds heralds the onset of delayed neuropathic damage in animals and humans.	Organophosphorus Compounds	100-126	patatin like phospholipase domain containing 6	Homo sapiens	69-72
34185362-1	2021	Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms.	Organophosphorus Compounds	29-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-146
34185362-1	2021	Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms.	Organophosphorus Compounds	29-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
34185362-1	2021	Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms.	Organophosphorus Compounds	57-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-146
34185362-1	2021	Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms.	Organophosphorus Compounds	57-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
3376120-2	1988	Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE).	Organophosphorus Compounds	5-31	patatin like phospholipase domain containing 6	Homo sapiens	136-162
3376120-2	1988	Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE).	Organophosphorus Compounds	5-31	patatin like phospholipase domain containing 6	Homo sapiens	164-167
3715916-1	1986	Neurotoxic esterase (NTE) is a protein which is hypothesized to be the site where certain organophosphorus compounds act to produce delayed-onset neurotoxicity.	Organophosphorus Compounds	90-116	patatin like phospholipase domain containing 6	Gallus gallus	0-19
3715916-1	1986	Neurotoxic esterase (NTE) is a protein which is hypothesized to be the site where certain organophosphorus compounds act to produce delayed-onset neurotoxicity.	Organophosphorus Compounds	90-116	patatin like phospholipase domain containing 6	Gallus gallus	21-24
4015398-0	1985	Phthalates and organophosphorus compounds as cholinesterase inhibitors in fractions of industrial hexane impurities.	Organophosphorus Compounds	15-41	butyrylcholinesterase	Homo sapiens	45-59
3619246-2	1987	Lymphocytic NTE activity was measured after intoxication by organo phosphorus compounds and in chronic alcoholics at the beginning of alcohol withdrawal.	Organophosphorus Compounds	60-87	patatin like phospholipase domain containing 6	Homo sapiens	12-15
3775817-1	1986	In this study whole blood cholinesterase activities were determined (tintometric method) of agricultural pesticide users exposed to organophosphorus compounds in Indonesia, Malaysia, Sri Lanka and Thailand.	Organophosphorus Compounds	132-158	butyrylcholinesterase	Homo sapiens	26-40
3699334-0	1986	Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds.	Organophosphorus Compounds	130-156	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-116
3952739-8	1986	This study indicates that assay of lymphocyte NTE can provide a good monitor of exposure to axonotoxic organophosphorus compounds within 24 hr between exposure and measurement.	Organophosphorus Compounds	103-129	patatin like phospholipase domain containing 6	Homo sapiens	46-49
3952746-1	1986	Organophosphorus compounds (OPs) that cause organophosphorus ester-induced delayed neuropathy (OPIDN) generally inhibit neurotoxic esterase (NTE).	Organophosphorus Compounds	0-26	patatin like phospholipase domain containing 6	Gallus gallus	141-144
3952746-1	1986	Organophosphorus compounds (OPs) that cause organophosphorus ester-induced delayed neuropathy (OPIDN) generally inhibit neurotoxic esterase (NTE).	Organophosphorus Compounds	28-31	patatin like phospholipase domain containing 6	Gallus gallus	141-144