PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 20955204-5 2011 In-cell ELISA and immunofluorescence microscopy revealed an increase in the expression of syndecan-4 and its rearrangement to form focal adhesions in both cell types after PL exposure. pl 172-174 syndecan 4 Homo sapiens 90-100 21385008-5 2011 Moreover, PL induced a strong cell actin cytoskeletal re-organization that persisted up to 24 h. The accelerated wound closure promoted by PL, in either presence or absence of serum, was associated with a high expression of the inflammatory cytokine interleukin-8. pl 10-12 C-X-C motif chemokine ligand 8 Homo sapiens 250-263 21385008-5 2011 Moreover, PL induced a strong cell actin cytoskeletal re-organization that persisted up to 24 h. The accelerated wound closure promoted by PL, in either presence or absence of serum, was associated with a high expression of the inflammatory cytokine interleukin-8. pl 139-141 C-X-C motif chemokine ligand 8 Homo sapiens 250-263 21385008-6 2011 Further, after 24 h PL treatment, confluent keratinocytes also expressed low amounts of interleukin-8 and of the antimicrobial peptide neutrophil gelatinase-associated lipocalin, which dramatically increased under inflammatory conditions. pl 20-22 C-X-C motif chemokine ligand 8 Homo sapiens 88-101 22249932-3 2012 RESULTS: PL caused peribronchial and perivascular inflammation that peaked at 18-24 h. Polymorphonuclear cells (PMNs) began to accumulate in bronchoalveolar lavage fluid (BALF) of PL-challenged mice by 4 h and accounted for >90% of leukocytes by 18-24 h. Inflammation was marked by the appearance of MIP-2, KC, TNF-alpha, and IL-6 in the BALF with peak levels attained 4 h after PL administration. pl 9-11 chemokine (C-X-C motif) ligand 2 Mus musculus 303-308 22249932-3 2012 RESULTS: PL caused peribronchial and perivascular inflammation that peaked at 18-24 h. Polymorphonuclear cells (PMNs) began to accumulate in bronchoalveolar lavage fluid (BALF) of PL-challenged mice by 4 h and accounted for >90% of leukocytes by 18-24 h. Inflammation was marked by the appearance of MIP-2, KC, TNF-alpha, and IL-6 in the BALF with peak levels attained 4 h after PL administration. pl 9-11 tumor necrosis factor Mus musculus 314-323 22249932-3 2012 RESULTS: PL caused peribronchial and perivascular inflammation that peaked at 18-24 h. Polymorphonuclear cells (PMNs) began to accumulate in bronchoalveolar lavage fluid (BALF) of PL-challenged mice by 4 h and accounted for >90% of leukocytes by 18-24 h. Inflammation was marked by the appearance of MIP-2, KC, TNF-alpha, and IL-6 in the BALF with peak levels attained 4 h after PL administration. pl 9-11 interleukin 6 Mus musculus 329-333 22249932-8 2012 CONCLUSIONS: These results strongly suggest that PL-induced lung inflammation is dependent on an innate MyD88-dependent pathway rather than the Ig-binding properties of this microbial B cell superantigen. pl 49-51 myeloid differentiation primary response gene 88 Mus musculus 104-109 20512938-3 2010 Further analyses made on HuVEC showed that the ERK inhibitor PD98059 maximally inhibited the PL-induced endothelial repair, followed in order of importance by the calcium chelator BAPTA-AM, the PI3K inhibitor wortmannin and the p38 inhibitor SB203580. pl 93-95 mitogen-activated protein kinase 1 Homo sapiens 47-50 20512938-3 2010 Further analyses made on HuVEC showed that the ERK inhibitor PD98059 maximally inhibited the PL-induced endothelial repair, followed in order of importance by the calcium chelator BAPTA-AM, the PI3K inhibitor wortmannin and the p38 inhibitor SB203580. pl 93-95 mitogen-activated protein kinase 1 Homo sapiens 228-231 20512938-6 2010 Western blot analysis on scratch wounded HuVEC showed that PL induced no activation of p38, a transient activation of AKT, and a sustained activation of ERK1/2. pl 59-61 mitogen-activated protein kinase 3 Homo sapiens 153-159 20512938-7 2010 The complex of data indicates that, although different signalling pathways are involved in PL-promoted endothelial repair, the process is chiefly under the control of ERK1/2. pl 91-93 mitogen-activated protein kinase 3 Homo sapiens 167-173 20040336-2 2010 The mechanism of action is thought to involve activation of the PPARalpha-MDR3-phospholipid (PL) secretion pathway. pl 93-95 ATP binding cassette subfamily B member 4 Homo sapiens 64-78 20496666-7 2010 The relationship between PL area of integration and PL intensity of maximum of nanocrystalline ZnO films at different ratio of O2/Ar in processing was given. pl 25-27 immunoglobulin kappa variable 1D-39 Homo sapiens 127-132 20496666-7 2010 The relationship between PL area of integration and PL intensity of maximum of nanocrystalline ZnO films at different ratio of O2/Ar in processing was given. pl 52-54 immunoglobulin kappa variable 1D-39 Homo sapiens 127-132 19846483-10 2010 These results demonstrate for the first time that the avian ZP gene is expressed in the oocyte, and that the ZP2 protein in the oocyte might play a role for the PL formation in the immature follicles of the ovary. pl 161-163 zona pellucida sperm-binding protein 2 Coturnix japonica 109-112 19519274-7 2009 PL-supplemented cultures resulted in significantly larger colonies, shorter culture time period, and higher population doublings between P1 and P3 compared to FBS-containing cultures. pl 0-2 crystallin gamma F, pseudogene Homo sapiens 137-146 19456168-5 2009 The strong local field enhancement due to nanogaps between Au NPs in the background of a light-emitting MEH-PPV NP might be another origin of the PL enhancement of the NP complex, as supported by finite difference time domain calculations. pl 146-148 epoxide hydrolase 1 Homo sapiens 104-107 19686468-8 2009 Furthermore, in a separate experiment, a prior experience with controllable stress led to potentiation of Fos expression in retrogradely labeled PL neurons in response to an uncontrollable stressor 1 week later. pl 145-147 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-109 19661340-5 2009 We infer that a combination of ascorbate with PL is beneficial to cancer management via the simultaneous inhibition of cell growth and expression of MMP-1, TGF-beta and HSPs, and furthermore, the stimulation of TIMP-1. pl 46-48 matrix metallopeptidase 1 Homo sapiens 149-154 19661340-5 2009 We infer that a combination of ascorbate with PL is beneficial to cancer management via the simultaneous inhibition of cell growth and expression of MMP-1, TGF-beta and HSPs, and furthermore, the stimulation of TIMP-1. pl 46-48 TIMP metallopeptidase inhibitor 1 Homo sapiens 211-217 19555769-6 2009 Western blot analyses of scratch wounded cells showed activation of AKT and p38, while in the presence of PL there was a faster and sustained activation of AKT and p38 (up to 6h), and a transient activation of ERK1/2. pl 106-108 mitogen-activated protein kinase 14 Mus musculus 164-167 19555769-6 2009 Western blot analyses of scratch wounded cells showed activation of AKT and p38, while in the presence of PL there was a faster and sustained activation of AKT and p38 (up to 6h), and a transient activation of ERK1/2. pl 106-108 mitogen-activated protein kinase 3 Mus musculus 210-216 19267882-8 2009 Data indicate that cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding per se, PI3K is essential for PL effects and its downstream effector Akt is activated only in the presence of PL. pl 123-125 mitogen-activated protein kinase 1 Homo sapiens 90-93 19267882-8 2009 Data indicate that cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding per se, PI3K is essential for PL effects and its downstream effector Akt is activated only in the presence of PL. pl 123-125 mitogen-activated protein kinase 3 Homo sapiens 98-104 19267882-8 2009 Data indicate that cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding per se, PI3K is essential for PL effects and its downstream effector Akt is activated only in the presence of PL. pl 123-125 mitogen-activated protein kinase 1 Homo sapiens 90-93 19267882-8 2009 Data indicate that cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding per se, PI3K is essential for PL effects and its downstream effector Akt is activated only in the presence of PL. pl 123-125 mitogen-activated protein kinase 3 Homo sapiens 98-104 19267882-8 2009 Data indicate that cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding per se, PI3K is essential for PL effects and its downstream effector Akt is activated only in the presence of PL. pl 123-125 mitogen-activated protein kinase 1 Homo sapiens 90-93 19267882-8 2009 Data indicate that cell Ca2(+) plays a fundamental role in wound healing even without PL, p38 and ERK1/2 are essential for PL effects but are also activated by wounding per se, PI3K is essential for PL effects and its downstream effector Akt is activated only in the presence of PL. pl 123-125 mitogen-activated protein kinase 3 Homo sapiens 98-104 18541455-9 2008 Doping of CdS with Zn2+ and Cu2+ is found to enhance the PL intensity. pl 57-59 CDP-diacylglycerol synthase 1 Homo sapiens 10-13 19265384-6 2009 Modification of ZnO NCs with Co(II) resulted in the transfer of photoexcited electrons to the cobalt center where consequent nonradiative recombination, at energies lower than required for PC, was observed via a comparable decrease in both PL and PC activity. pl 240-242 mitochondrially encoded cytochrome c oxidase II Homo sapiens 29-35 19070893-10 2009 In placenta, PPARalpha, PPARdelta and PPARgamma protein expression was significantly increased in the IL group compared to the NIL or PL group. pl 134-136 peroxisome proliferator activated receptor gamma Homo sapiens 38-47 18616790-12 2008 CONCLUSIONS: Data indicate that PL increases wound healing rate by stimulating keratinocyte migration through a calcium- and p38-dependent mechanism. pl 32-34 mitogen-activated protein kinase 1 Homo sapiens 125-128 19159346-5 2008 Most PL particles were seen in the CP portion of the axonal plasma membranes, suggesting that the anti-TrkB antibody binds to the membrane-inserted TrkB that acts as a functional receptor. pl 5-7 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 103-107 19159346-5 2008 Most PL particles were seen in the CP portion of the axonal plasma membranes, suggesting that the anti-TrkB antibody binds to the membrane-inserted TrkB that acts as a functional receptor. pl 5-7 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 148-152 18789914-7 2008 A significantly higher percentage of circulating PL contained depolarised mitochondria (p=0.0003) which correlated with disease activity and C-reactive protein levels in patients. pl 49-51 C-reactive protein Homo sapiens 141-159 17338907-5 2006 The mean IL-6 concentration increased from 3 pg/ml in both groups pre-operatively to 78.5 pg/ml (PL group) vs 74.8 pg/ml (MIS group) at 6 hours post-operatively and reached a maximum of 100 pg/ml (PL group) vs 90.5 pg/ml pg/ml (MIS group) after 24 hours. pl 97-99 interleukin 6 Homo sapiens 9-13 17927236-2 2007 The concentration of MEH-PPV in the PP blend is designed to be fairly low (0.01 wt %) in order to observe the intrinsic intrachain PL property of MEH-PPV in the solid state. pl 131-133 epoxide hydrolase 1 Homo sapiens 21-24 17927236-2 2007 The concentration of MEH-PPV in the PP blend is designed to be fairly low (0.01 wt %) in order to observe the intrinsic intrachain PL property of MEH-PPV in the solid state. pl 131-133 epoxide hydrolase 1 Homo sapiens 146-149 17927236-11 2007 Finally, based on an argument on the different magnitudes of Stokes shift between the blend sample and the neat film, we conclude that the PL of MEH-PPV in the neat film predominantly occurs at the site of interchain excitations via the interchain migration of excitons. pl 139-141 epoxide hydrolase 1 Homo sapiens 145-148 18076675-5 2008 METHODS: A 36-year-old female with PL associated with a heterozygous PPARG mutation complicated by poorly controlled diabetes and severe, refractory hypertriglyceridaemia was enrolled in a National Institutes of Health (NIH) protocol to evaluate the role of r-metHuLeptin in lipodystrophy. pl 35-37 peroxisome proliferator activated receptor gamma Homo sapiens 69-74 18179197-5 2008 The solid-state emission spectrum of BTCD-60 was found to show almost a 5-6 times enhancement in PL intensity as compared to that of MEH-PPV. pl 97-99 Kin17 DNA and RNA binding protein Homo sapiens 37-41 18175967-5 2008 The results showed that total escins (1 mg/ml) as well as two compounds isolated from total escins, namely escin Ib and IIa, showed inhibitory effects on PL activity. pl 154-156 ATPase, class II, type 9A Mus musculus 120-123 17845214-2 2007 We found that pretreatment of human keratinocytes with PL inhibited SSR-mediated increase of tumor necrosis factor (TNF)-alpha and also abrogated nitric oxide (NO) production. pl 55-57 tumor necrosis factor Homo sapiens 93-126 17338907-5 2006 The mean IL-6 concentration increased from 3 pg/ml in both groups pre-operatively to 78.5 pg/ml (PL group) vs 74.8 pg/ml (MIS group) at 6 hours post-operatively and reached a maximum of 100 pg/ml (PL group) vs 90.5 pg/ml pg/ml (MIS group) after 24 hours. pl 197-199 interleukin 6 Homo sapiens 9-13 17338907-7 2006 The post-operative mean H-FABP concentration increased to 10.7 microg/l in the PL group vs 15.8 microg/l in the MIS group. pl 79-81 fatty acid binding protein 3 Homo sapiens 24-30 15564728-7 2004 Cs A administration to the rats increased RBC membrane cholesterol (CHO) levels and the CHO/phospholipid (PL) ratio significantly (p < 0.01 and p < 0.05, respectively) but did not change RBC membrane proteins and membrane PL levels. pl 106-108 chorionic somatomammotropin hormone 1 Homo sapiens 0-4 15355401-8 2004 In the case of confluent bone cells, the presence of PL (from 1 x 10(6) to 3 x 10(8) platelets/ml) for 11 days, the ALP specific activity and total calcium content decreased in a PL dose-dependent manner and reached a minimum in the presence of PL from 3 x 10(8) platelets/ml. pl 53-55 alkaline phosphatase, placental Homo sapiens 116-119 15355401-8 2004 In the case of confluent bone cells, the presence of PL (from 1 x 10(6) to 3 x 10(8) platelets/ml) for 11 days, the ALP specific activity and total calcium content decreased in a PL dose-dependent manner and reached a minimum in the presence of PL from 3 x 10(8) platelets/ml. pl 179-181 alkaline phosphatase, placental Homo sapiens 116-119 15355401-8 2004 In the case of confluent bone cells, the presence of PL (from 1 x 10(6) to 3 x 10(8) platelets/ml) for 11 days, the ALP specific activity and total calcium content decreased in a PL dose-dependent manner and reached a minimum in the presence of PL from 3 x 10(8) platelets/ml. pl 179-181 alkaline phosphatase, placental Homo sapiens 116-119 15355401-9 2004 In summary, short-term PL exposure (up to 24 h) promotes the proliferative and chemotactic bone cell functions while long-term PL exposure results in a decrease of both ALP activity and mineral formation. pl 127-129 alkaline phosphatase, placental Homo sapiens 169-172 15255989-6 2004 All LC neurons and a significant proportion of PL neurons were engaged during several aspects of a Go/NoGo task, especially after the signal for trial onset and CS+ presentation. pl 47-49 reticulon 4 Rattus norvegicus 102-106 15147379-1 2004 The C2 domain of factor VIII (FVIII) is important for FVIII-phospholipid (PL) and FVIII-von Willebrand factor (VWF) interactions. pl 74-76 coagulation factor VIII Homo sapiens 17-28 15147379-1 2004 The C2 domain of factor VIII (FVIII) is important for FVIII-phospholipid (PL) and FVIII-von Willebrand factor (VWF) interactions. pl 74-76 coagulation factor VIII Homo sapiens 30-35 15147379-1 2004 The C2 domain of factor VIII (FVIII) is important for FVIII-phospholipid (PL) and FVIII-von Willebrand factor (VWF) interactions. pl 74-76 coagulation factor VIII Homo sapiens 54-59 15564728-7 2004 Cs A administration to the rats increased RBC membrane cholesterol (CHO) levels and the CHO/phospholipid (PL) ratio significantly (p < 0.01 and p < 0.05, respectively) but did not change RBC membrane proteins and membrane PL levels. pl 228-230 chorionic somatomammotropin hormone 1 Homo sapiens 0-4 10079520-4 1999 In this report, we have further analyzed the functional importance of N-cadherin in the cellular condensation-chondrogenesis pathway by examining N-cadherin expression and related activities in high density micromass cultures of chick limb mesenchymal cells in which chondrogenesis is being stimulated with the cationic polymer, poly-L-lysine (PL). pl 344-346 cadherin 2 Gallus gallus 70-80 12512935-7 2002 Analysis by electrophoresis showed a marked decrease in P0 and MBP at 7 days PL in young rats and 14 days PL in adult rats. pl 77-79 myelin basic protein Rattus norvegicus 63-66 11014211-3 2000 We report the novel finding that all ECMs tested, but not a nonspecific attachment factor, poly-L-lysine (PL), promoted a highly synergistic proliferative response to EGF plus IGF-I. pl 106-108 epidermal growth factor Mus musculus 167-170 15507266-4 2004 Raised numbers of circulating CD5+ B cells correlate with high levels of anti-phospholipid (PL) Ab in some APS patients, and participate in altered immunity of women with recurrent spontaneous abortion. pl 92-94 CD5 molecule Homo sapiens 30-33 12076864-7 2002 The regeneration ratio and the proliferating cell nuclear antigen (PCNA) labeling index in the PL group was markedly higher than in the sham group 24h after hepatectomy. pl 95-97 proliferating cell nuclear antigen Rattus norvegicus 31-65 12076864-7 2002 The regeneration ratio and the proliferating cell nuclear antigen (PCNA) labeling index in the PL group was markedly higher than in the sham group 24h after hepatectomy. pl 95-97 proliferating cell nuclear antigen Rattus norvegicus 67-71 10079520-6 1999 Immunohistochemistry, immunoblotting, and Northern blot analysis all show that PL treatment results in a time-dependent increase in N-cadherin expression at both the protein and mRNA levels. pl 79-81 cadherin 2 Gallus gallus 132-142 10079520-8 1999 PL treatment also alters the tyrosine-phosphorylation state of the N-cadherin associated signaling protein, beta-catenin. pl 0-2 cadherin 2 Gallus gallus 67-77 10079520-8 1999 PL treatment also alters the tyrosine-phosphorylation state of the N-cadherin associated signaling protein, beta-catenin. pl 0-2 catenin beta 1 Gallus gallus 108-120 8642640-7 1996 In cows with PL (n=5), BLV-infected CD5+ and CD5- B cells accounted for 66% +/- 4.8% and 13.9% +/- 6.6% of circulating B lymphocytes, respectively. pl 13-15 CD5 molecule Bos taurus 36-39 8642640-7 1996 In cows with PL (n=5), BLV-infected CD5+ and CD5- B cells accounted for 66% +/- 4.8% and 13.9% +/- 6.6% of circulating B lymphocytes, respectively. pl 13-15 CD5 molecule Bos taurus 45-48 8525084-3 1995 The percentage of IgM-bearing cells was significantly higher in the BLV+PL+ group than in the BLV-PL- and BLV+PL- groups by FACS. pl 72-74 IgM Bos taurus 18-21 8668679-3 1996 METHODS: A molecular conjugate consisting of EGF and poly-L-lysine (PL) was synthesized and complexed with 5" fluorescently-labeled oligonucleotide. pl 68-70 epidermal growth factor Homo sapiens 45-48 1735616-9 1992 Transition from a PL state to overt thymic lymphoma involves emancipation of a PL cell from IL-4 dependency. pl 18-20 interleukin 4 Mus musculus 92-96 34802947-11 2021 Moreover, the anti-inflammatory effect of PL was evidenced by the maintenance of AnxA1 levels, reduction of COX-2 (p < 0,05), Bcl-2 (p < 0,01) and NF-kB (p < 0,001) expressions and decreased IL-1beta, IL-17 (p < 0,01) and TNF-alpha (p < 0,05) levels. pl 42-44 annexin A1 Mus musculus 81-86 33807038-4 2021 Additionally, CS was measured in PL Group and exhibited a significant improvement in the AE one month after the beginning of treatment for 3, 6, 12, and 18 cycles/o (p = 0.003). pl 33-35 citrate synthase Homo sapiens 14-16 22849563-8 2013 Among the patients with familial MM, those exhibiting a mutated CDKN2A and/or polymorphisms in MC1R had the bigger differences in response to treatment with PL. pl 157-159 cyclin dependent kinase inhibitor 2A Homo sapiens 64-70 22849563-8 2013 Among the patients with familial MM, those exhibiting a mutated CDKN2A and/or polymorphisms in MC1R had the bigger differences in response to treatment with PL. pl 157-159 melanocortin 1 receptor Homo sapiens 95-99 34600321-7 2022 The PL intensity can be significantly enhanced by 2.9 times after doping 2 mol% Gd3+ ions in Sr3LiSbO6. pl 4-6 GRDX Homo sapiens 80-83 34885945-8 2021 Hydroalcoholic PL extract and its components (5-Dodecanolide, Oleamide, and Resolvin D1) exerted an anti-inflammatory effect on LPS-stimulated neutrophils and peripheral mononuclear cells reducing the capability to produce TNFalpha, as well as the activities of antioxidant and pro-inflammatory enzymes. pl 15-17 tumor necrosis factor Rattus norvegicus 223-231 34802947-11 2021 Moreover, the anti-inflammatory effect of PL was evidenced by the maintenance of AnxA1 levels, reduction of COX-2 (p < 0,05), Bcl-2 (p < 0,01) and NF-kB (p < 0,001) expressions and decreased IL-1beta, IL-17 (p < 0,01) and TNF-alpha (p < 0,05) levels. pl 42-44 prostaglandin-endoperoxide synthase 2 Mus musculus 108-113 34802947-11 2021 Moreover, the anti-inflammatory effect of PL was evidenced by the maintenance of AnxA1 levels, reduction of COX-2 (p < 0,05), Bcl-2 (p < 0,01) and NF-kB (p < 0,001) expressions and decreased IL-1beta, IL-17 (p < 0,01) and TNF-alpha (p < 0,05) levels. pl 42-44 B cell leukemia/lymphoma 2 Mus musculus 126-131 34802947-11 2021 Moreover, the anti-inflammatory effect of PL was evidenced by the maintenance of AnxA1 levels, reduction of COX-2 (p < 0,05), Bcl-2 (p < 0,01) and NF-kB (p < 0,001) expressions and decreased IL-1beta, IL-17 (p < 0,01) and TNF-alpha (p < 0,05) levels. pl 42-44 interleukin 1 alpha Mus musculus 191-199 34802947-11 2021 Moreover, the anti-inflammatory effect of PL was evidenced by the maintenance of AnxA1 levels, reduction of COX-2 (p < 0,05), Bcl-2 (p < 0,01) and NF-kB (p < 0,001) expressions and decreased IL-1beta, IL-17 (p < 0,01) and TNF-alpha (p < 0,05) levels. pl 42-44 interleukin 17A Mus musculus 201-206 34802947-11 2021 Moreover, the anti-inflammatory effect of PL was evidenced by the maintenance of AnxA1 levels, reduction of COX-2 (p < 0,05), Bcl-2 (p < 0,01) and NF-kB (p < 0,001) expressions and decreased IL-1beta, IL-17 (p < 0,01) and TNF-alpha (p < 0,05) levels. pl 42-44 tumor necrosis factor Mus musculus 222-231 34826194-7 2021 For antioxidants, the PL group had markedly decreased T-AOC and CAT activity, but markedly increased SOD activity. pl 22-24 catalase Rattus norvegicus 64-67 34826194-7 2021 For antioxidants, the PL group had markedly decreased T-AOC and CAT activity, but markedly increased SOD activity. pl 22-24 superoxide dismutase 1 Rattus norvegicus 101-104 34868247-7 2021 The comparative expression analysis of these ABGs indicated that the upregulation of TT8 together with its target genes (such as DFR, ANS, UFGT, and TT19) might promote the anthocyanin accumulation in PL at the early developmental stage (41-91 days). pl 201-203 dihydroflavonol-4-reductase Brassica napus 129-132 34869518-4 2021 In this preclinical study, we assessed the effects of a chronic supplementation with a source of PL extracted from an alpha-lactalbumin enriched whey protein containing 10% lipids from early life (post-natal day (PND) 7) to adulthood (PND 72) on adult motor skills, anxiety, and long-term memory. pl 97-99 lactalbumin alpha Homo sapiens 118-135 33875111-3 2021 It is demonstrated that the resonant coupling between graphene SPs and GaN exciton emission is responsible for the substantially enhanced PL from the structure of graphene/GaN nanofilm. pl 138-140 gigaxonin Homo sapiens 71-74 34642434-11 2021 PRP and PL groups combined with mechanical loading showed upregulation of COL2A1, ACAN and COMP. pl 8-10 collagen type II alpha 1 chain Homo sapiens 74-80 34642434-11 2021 PRP and PL groups combined with mechanical loading showed upregulation of COL2A1, ACAN and COMP. pl 8-10 aggrecan Homo sapiens 82-86 34642434-12 2021 The highest amount of total TGF-beta1 was quantified in the PL group. pl 60-62 transforming growth factor beta 1 Homo sapiens 28-37 34642434-13 2021 Latent TGF-beta1 was activated in all loaded groups, while the highest amount was found in the PL group. pl 95-97 transforming growth factor beta 1 Homo sapiens 7-16 34642434-19 2021 Loading presumably can enhance the action of TGF-beta1, which was predominantly activated in loaded PL groups. pl 100-102 transforming growth factor beta 1 Homo sapiens 45-54 34610057-8 2021 The MEH-PPV/MgO nanocomposite displayed 23% PL quantum efficiency. pl 44-46 epoxide hydrolase 1 Homo sapiens 4-7 34555892-5 2021 To enhance the room-temperature PL property of K3Lu(PO4)2:Pr3+, a polymorphous adjustment strategy was proposed by the use of the ion-doping method. pl 32-34 proteinase 3 Homo sapiens 58-61 33875111-3 2021 It is demonstrated that the resonant coupling between graphene SPs and GaN exciton emission is responsible for the substantially enhanced PL from the structure of graphene/GaN nanofilm. pl 138-140 gigaxonin Homo sapiens 172-175 34254396-7 2021 By precisely adjusting the crystallinity and crystal cellulose conversion of MCC, the changing trend of quantum efficiency and p-RTP lifetime is consistent with the change of crystallinity, and the cellulose Imay be more beneficial to PL emission than cellulose II. pl 235-237 MORN repeat containing 4 Homo sapiens 129-132 34311512-6 2021 PL treatment reduced CD80,CD86 and PDL-1 and enhanced CD206 and CD200R expression on macrophages analyzed by cytofluorimetry. pl 0-2 CD80 molecule Homo sapiens 21-25 34311512-6 2021 PL treatment reduced CD80,CD86 and PDL-1 and enhanced CD206 and CD200R expression on macrophages analyzed by cytofluorimetry. pl 0-2 CD86 molecule Homo sapiens 26-30 34311512-6 2021 PL treatment reduced CD80,CD86 and PDL-1 and enhanced CD206 and CD200R expression on macrophages analyzed by cytofluorimetry. pl 0-2 CD274 molecule Homo sapiens 35-40 34116758-4 2021 To this, PPO was treated by PL at different pHs (4.0-6.5) and its inactivation kinetics and changes in its structure were evaluated by spectrophotometric and spectrofluorometric methods. pl 28-30 protoporphyrinogen oxidase Homo sapiens 9-12 34311512-6 2021 PL treatment reduced CD80,CD86 and PDL-1 and enhanced CD206 and CD200R expression on macrophages analyzed by cytofluorimetry. pl 0-2 mannose receptor C-type 1 Homo sapiens 54-59 34311512-6 2021 PL treatment reduced CD80,CD86 and PDL-1 and enhanced CD206 and CD200R expression on macrophages analyzed by cytofluorimetry. pl 0-2 CD200 receptor 1 Homo sapiens 64-70 34311512-11 2021 Our results demonstrate that PL dampens the macrophage secretion of pro-inflammatory cytokines and induces the release of arginase, TGF-beta and VEGF that may affect angiogenesis and tissue regeneration, thus facilitating the wound healing process. pl 29-31 transforming growth factor alpha Homo sapiens 132-140 34311512-11 2021 Our results demonstrate that PL dampens the macrophage secretion of pro-inflammatory cytokines and induces the release of arginase, TGF-beta and VEGF that may affect angiogenesis and tissue regeneration, thus facilitating the wound healing process. pl 29-31 vascular endothelial growth factor A Homo sapiens 145-149 34116758-9 2021 Beyond the specific outcome for PPO, the results are evidence of a general pH-independence in the mechanism of enzyme inactivation by PL in the pH range 4.0-6.5 and acidification can be a strategy to decrease treatment times during PL processing. pl 134-136 protoporphyrinogen oxidase Homo sapiens 32-35 34176927-5 2021 In HeLa and 4T1 cells, LDHA or LDHB knockout or LDH inhibitor FX11 significantly decreased ROS induction by modulators of the mitochondrial electron transfer chain (antimycin, oligomycin, rotenone), hypoxia, and pharmacological ROS inducers piperlogumine (PL) and phenethyl isothiocyanate (PEITC). pl 256-258 lactate dehydrogenase A Mus musculus 23-27 34345193-10 2021 In the change from PL to OCM, operative time, CRP and CK decreased, but Hb also decreased. pl 19-21 C-reactive protein Homo sapiens 46-49 34345193-10 2021 In the change from PL to OCM, operative time, CRP and CK decreased, but Hb also decreased. pl 19-21 cytidine/uridine monophosphate kinase 1 Homo sapiens 54-56 34176927-5 2021 In HeLa and 4T1 cells, LDHA or LDHB knockout or LDH inhibitor FX11 significantly decreased ROS induction by modulators of the mitochondrial electron transfer chain (antimycin, oligomycin, rotenone), hypoxia, and pharmacological ROS inducers piperlogumine (PL) and phenethyl isothiocyanate (PEITC). pl 256-258 lactate dehydrogenase A Homo sapiens 48-51 35001885-9 2022 CONCLUSIONS: PL rate before gw22 among singleton pregnancies with AD and/or MTHFR polymorphisms was 35.8%. pl 13-15 methylenetetrahydrofolate reductase Homo sapiens 76-81 35381293-8 2022 ERK phosphorylation in response to fetal calf serum or 1 ng/ml EGF was nearly as efficient in OS cell lines and one FN-RMS cell line in suspension as cells adherent to poly-l-lysine (PL) or fibronectin (FN). pl 183-185 mitogen-activated protein kinase 1 Homo sapiens 0-3 35596539-6 2022 There was a disagreement in PD-L1 expression on TCs between paired BM and PL lesions in 15 cases and on ICs in seven cases. pl 74-76 CD274 molecule Homo sapiens 28-33 35131296-14 2022 The present study provides evidence for a miR-34a-dependent mechanism underlying the fast-acting antidepressant-like actions of (2R,6R)-HNK, indicating a novel role of PL miR-34a in antidepression. pl 168-170 microRNA 34a Mus musculus 171-178 35420771-6 2022 Tunable PL compositions will require fundamental investigations of competitive gas binding mechanisms, thermal effects on binding site stability, and the role of nanoconfinement on gas and solvent diffusion that can be accelerated through molecular modeling. pl 8-10 gastrin Homo sapiens 79-82 35420771-6 2022 Tunable PL compositions will require fundamental investigations of competitive gas binding mechanisms, thermal effects on binding site stability, and the role of nanoconfinement on gas and solvent diffusion that can be accelerated through molecular modeling. pl 8-10 gastrin Homo sapiens 181-184 35170302-7 2022 For first time, we performed tip-enhanced PL imaging of freestanding 2D materials and studied the competition between the PL enhancement mechanisms by nanoindentation as a function of the tip-sample distance. pl 122-124 TOR signaling pathway regulator Homo sapiens 188-191 35397211-3 2022 Furthermore, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. pl 77-79 somatostatin Homo sapiens 26-29 33687163-2 2021 The study aims to evaluate metformin"s efficacy in preventing PL in fresh GnRH antagonist intracytoplasmic sperm injection (ICSI) cycles with cleavage-stage embryo transfer. pl 62-64 gonadotropin releasing hormone 1 Homo sapiens 74-78 3125740-3 1988 Results demonstrate that IFN-gamma release by elicited PL is lower in some CAPD patients with high peritonitis incidence (HPI) than in healthy donors or in CAPD patients with low peritonitis incidence (LPI). pl 55-57 interferon gamma Homo sapiens 25-34 2957818-3 1987 This result was in contrast to that obtained with poly-D-lysine (PL) stimulated t-PA, where minactivin was a potent inhibitor. pl 65-67 plasminogen activator, tissue type Homo sapiens 80-84 3089269-1 1986 Fractionation of a human antibody to factor VIII: Ag by immunoabsorption with factor VIII/phospholipid (PL) complex has produced two pools of labelled Fab" fragments which can be used in fluid-phase immunoradiometric assays (IRMAs). pl 104-106 FA complementation group B Homo sapiens 151-154 6483865-4 1984 A significant increase in PL content of alpha-MSH compared to Days 5-11 and 17-20 occurred on Day 4 of gestation, and no significant changes were detected in the AP concentration of alpha-MSH throughout the period studied. pl 26-28 proopiomelanocortin Rattus norvegicus 40-49 34029467-2 2021 While having no detectable influence on absorbance of this conjugated polymer, our experiments clearly revealed that illumination of PDOPT caused a significant increase in the PL intensity (IPL(T,t)), that is, the emission probability of PDOPT. pl 176-178 pleckstrin homology like domain family A member 2 Homo sapiens 190-193 33759503-5 2021 We find that reversible hole trapping leads to both delayed and trap PL, involving the same trap states. pl 69-71 TRAP Homo sapiens 29-33 33759503-5 2021 We find that reversible hole trapping leads to both delayed and trap PL, involving the same trap states. pl 69-71 TRAP Homo sapiens 64-68 33739084-5 2021 Although the PL of solid Cb-1/2/3 showed non-TADF properties with lifetimes only at several nanoseconds, the crystallographic studies have shown a root cause of pi pi stacking that quenched the TADF, and the theoretical calculations forecasted small singlet-triplet energy gaps (DeltaES-T) therein. pl 13-15 cannabinoid receptor 1 Homo sapiens 25-33 34049755-12 2022 The white blood cell count, neutrophil count, and CRP levels on postoperative day 7 significantly differed between the SSI and non-SSI cases in the PL group. pl 148-150 C-reactive protein Homo sapiens 50-53 33912879-6 2021 The expressions of the PL enhancement kinetics due to the trap deactivations by lasers of different wavelengths were derived. pl 23-25 TRAP Homo sapiens 58-62 32163062-4 2020 By taking advantage of the intense and long-lived PL of the nanoprobes, the short-lived background autofluorescence can be completely eliminated, which enables the sensitive detection of beta-hCG with a linear range of 0-10 ng mL-1 and a detection limit down to 6.1 pg mL-1, approximately two orders of magnitude improvement relative to that of a commercial beta-hCG assay kit. pl 50-52 L1 cell adhesion molecule Mus musculus 227-231 33880356-5 2021 Methods: Three-step culture media supplemented with PL or fetal bovine serum (FBS) were used for proliferation and differentiation of CD34+ umbilical cord blood stem cells to erythrocytes in co-culture with bone marrow mesenchymal stem cells (BM-MSCs). pl 52-54 CD34 molecule Homo sapiens 134-138 33522125-4 2021 The Pb-doped Ag2 Se QDs (denoted as Pb:Ag2 Se QDs) present fire-new optical features with significantly enhanced PL intensity of 4.2 folds. pl 113-115 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 13-16 33522125-4 2021 The Pb-doped Ag2 Se QDs (denoted as Pb:Ag2 Se QDs) present fire-new optical features with significantly enhanced PL intensity of 4.2 folds. pl 113-115 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 39-42 33360073-7 2021 Moreover, the PL-loaded composite hydrogels inhibited the inflammatory response and dedifferentiation of IL-1beta-induced chondrocytes. pl 14-16 interleukin 1 alpha Homo sapiens 105-113 33360073-9 2021 RNA sequencing analysis indicated that PL"s protective effects might be associated with modulating hyaluronan synthase 1 (HAS-1) expression. pl 39-41 hyaluronan synthase 1 Homo sapiens 99-120 33360073-9 2021 RNA sequencing analysis indicated that PL"s protective effects might be associated with modulating hyaluronan synthase 1 (HAS-1) expression. pl 39-41 hyaluronan synthase 1 Homo sapiens 122-127 33058414-8 2020 During PL-induced chondrogenic differentiation of hUCMSCs, expression of H19 and SOX9 were increased, whereas miR-29b-3p expression was decreased. pl 7-9 H19 imprinted maternally expressed transcript Homo sapiens 73-76 33058414-8 2020 During PL-induced chondrogenic differentiation of hUCMSCs, expression of H19 and SOX9 were increased, whereas miR-29b-3p expression was decreased. pl 7-9 SRY-box transcription factor 9 Homo sapiens 81-85 33058414-9 2020 H19 overexpression promoted, whereas H19 silencing attenuated the PL-induced chondrogenic differentiation of hUCMSCs. pl 66-68 H19 imprinted maternally expressed transcript Homo sapiens 37-40 33058414-12 2020 In conclusion, PL induced chondrogenic differentiation of hUCMSCs by regulating the H19/miR-29b-3p/SOX9 axis. pl 15-17 H19 imprinted maternally expressed transcript Homo sapiens 84-87 33058414-12 2020 In conclusion, PL induced chondrogenic differentiation of hUCMSCs by regulating the H19/miR-29b-3p/SOX9 axis. pl 15-17 SRY-box transcription factor 9 Homo sapiens 99-103 32622597-4 2020 Given the key role played by the polar lipids (PL) (phospho- and sphingolipids) of the milk fat globule membrane (MFGM) in the immune system and cognitive development of the newborn, it is crucial to analyze whether the content and distribution of the PL are affected by gestation period. pl 47-49 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 87-112 32622597-4 2020 Given the key role played by the polar lipids (PL) (phospho- and sphingolipids) of the milk fat globule membrane (MFGM) in the immune system and cognitive development of the newborn, it is crucial to analyze whether the content and distribution of the PL are affected by gestation period. pl 47-49 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 114-118 32843766-8 2020 Creation of the PL tunnel tended to involve insertion from a more medial aspect for the PLD guide group than the conventional guide group. pl 16-18 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-91 32303304-4 2020 In this work, the effect of the administration of PL to horses with OA was analyzed both clinically and molecularly by determining the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), glycosaminoglycans (GAGs), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in synovial fluid. pl 50-52 matrix metallopeptidase 2 Equus caballus 145-171 32303304-4 2020 In this work, the effect of the administration of PL to horses with OA was analyzed both clinically and molecularly by determining the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), glycosaminoglycans (GAGs), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in synovial fluid. pl 50-52 matrix metallopeptidase 2 Equus caballus 173-178 32303304-4 2020 In this work, the effect of the administration of PL to horses with OA was analyzed both clinically and molecularly by determining the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), glycosaminoglycans (GAGs), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in synovial fluid. pl 50-52 matrix metallopeptidase 9 Equus caballus 181-207 32303304-4 2020 In this work, the effect of the administration of PL to horses with OA was analyzed both clinically and molecularly by determining the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), glycosaminoglycans (GAGs), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in synovial fluid. pl 50-52 matrix metallopeptidase 9 Equus caballus 209-214 32303304-4 2020 In this work, the effect of the administration of PL to horses with OA was analyzed both clinically and molecularly by determining the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), glycosaminoglycans (GAGs), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in synovial fluid. pl 50-52 ADAM metallopeptidase with thrombospondin type 1 motif 5 Equus caballus 217-281 32303304-4 2020 In this work, the effect of the administration of PL to horses with OA was analyzed both clinically and molecularly by determining the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), glycosaminoglycans (GAGs), and tissue inhibitor of metalloproteinase 1 (TIMP-1) in synovial fluid. pl 50-52 ADAM metallopeptidase with thrombospondin type 1 motif 5 Equus caballus 283-291 32303304-7 2020 The levels of MMP-9 decreased significantly (P < .05) on day 10 after treatment with PL. pl 85-87 matrix metallopeptidase 9 Equus caballus 14-19 32303304-12 2020 In conclusion, the beneficial effects of PL in OA could be attributed to the decreased activity of MMP-2, MMP-9, and ADAMTS-5 and the increased concentration of GAGs and TIMP-1 after the administration of platelet-rich plasma. pl 41-43 matrix metallopeptidase 2 Equus caballus 99-104 32303304-12 2020 In conclusion, the beneficial effects of PL in OA could be attributed to the decreased activity of MMP-2, MMP-9, and ADAMTS-5 and the increased concentration of GAGs and TIMP-1 after the administration of platelet-rich plasma. pl 41-43 matrix metallopeptidase 9 Equus caballus 106-111 32303304-12 2020 In conclusion, the beneficial effects of PL in OA could be attributed to the decreased activity of MMP-2, MMP-9, and ADAMTS-5 and the increased concentration of GAGs and TIMP-1 after the administration of platelet-rich plasma. pl 41-43 ADAM metallopeptidase with thrombospondin type 1 motif 5 Equus caballus 117-125 33404014-9 2021 We were able to identify the promising PL inhibition of hawthorn leaf herbal infusions at 1 mg mL-1 (37%) and PL activation by fresh and dry hawthorn flowers (~24%). pl 39-41 L1 cell adhesion molecule Mus musculus 95-99 33057008-8 2020 The in vitro results showed that PL significantly promoted the proliferation, cell cycle, and migration of huc-MSCs by upregulating relevant genes/proteins and activating beclin1-dependent autophagy via the AMPK/mTOR signaling pathway. pl 33-35 beclin 1 Homo sapiens 171-178 33057008-8 2020 The in vitro results showed that PL significantly promoted the proliferation, cell cycle, and migration of huc-MSCs by upregulating relevant genes/proteins and activating beclin1-dependent autophagy via the AMPK/mTOR signaling pathway. pl 33-35 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 207-211 33057008-8 2020 The in vitro results showed that PL significantly promoted the proliferation, cell cycle, and migration of huc-MSCs by upregulating relevant genes/proteins and activating beclin1-dependent autophagy via the AMPK/mTOR signaling pathway. pl 33-35 mechanistic target of rapamycin kinase Homo sapiens 212-216 33057008-9 2020 The main growth factors (PDGF-AA, IGF-1, TGF-beta, EGF, and FGF) contributed to the effects of PL in varying degrees. pl 95-97 insulin like growth factor 1 Homo sapiens 34-39 33057008-9 2020 The main growth factors (PDGF-AA, IGF-1, TGF-beta, EGF, and FGF) contributed to the effects of PL in varying degrees. pl 95-97 transforming growth factor alpha Homo sapiens 41-49 33057008-9 2020 The main growth factors (PDGF-AA, IGF-1, TGF-beta, EGF, and FGF) contributed to the effects of PL in varying degrees. pl 95-97 epidermal growth factor Homo sapiens 51-54 32876723-6 2020 The addition of LYZ would result in PL quenching from beta-CD-CuNCs. pl 36-38 lysozyme Homo sapiens 16-19 32876723-6 2020 The addition of LYZ would result in PL quenching from beta-CD-CuNCs. pl 36-38 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 54-61 32521330-8 2020 Mechanistically, the beneficial effects of a PL-loaded PEM coating might be related to activation of the hypoxia-inducible factor-1(Hif-1alpha)/vascular endothelial growth factor (VEGF) axis. pl 45-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 132-142 32521330-8 2020 Mechanistically, the beneficial effects of a PL-loaded PEM coating might be related to activation of the hypoxia-inducible factor-1(Hif-1alpha)/vascular endothelial growth factor (VEGF) axis. pl 45-47 vascular endothelial growth factor A Homo sapiens 144-178 32521330-8 2020 Mechanistically, the beneficial effects of a PL-loaded PEM coating might be related to activation of the hypoxia-inducible factor-1(Hif-1alpha)/vascular endothelial growth factor (VEGF) axis. pl 45-47 vascular endothelial growth factor A Homo sapiens 180-184 32791829-7 2020 A breakthrough regarding the efficient use of the mobile exciton for PL has recently been achieved by local chemical functionalization of the SWCNTs, in which the chemical reactions introduce local defects of oxygen and sp3 carbon atoms in the tube structures. pl 69-71 Sp3 transcription factor Homo sapiens 220-223 32638584-3 2020 We demonstrate a non-destructive modified gas-phase technique with co-deposition of both precursors trimethylaluminum (TMA) and water, to dramatically enhance the PL emission in zero-dimensional (0D) Cs4PbBr6 PNCs via alumina encapsulation. pl 163-165 gastrin Homo sapiens 42-45 32058216-8 2020 Pro-inflammatory cytokines TNF-alpha, IL-1 and IL-6 were decreased and anti-inflammatory cytokines IL-10 and TGF-beta were increased after treatment with PL compared to that in the TNBS group. pl 154-156 tumor necrosis factor Rattus norvegicus 27-36 32058216-8 2020 Pro-inflammatory cytokines TNF-alpha, IL-1 and IL-6 were decreased and anti-inflammatory cytokines IL-10 and TGF-beta were increased after treatment with PL compared to that in the TNBS group. pl 154-156 interleukin 6 Rattus norvegicus 47-51 32058216-8 2020 Pro-inflammatory cytokines TNF-alpha, IL-1 and IL-6 were decreased and anti-inflammatory cytokines IL-10 and TGF-beta were increased after treatment with PL compared to that in the TNBS group. pl 154-156 interleukin 10 Rattus norvegicus 99-104 32058216-8 2020 Pro-inflammatory cytokines TNF-alpha, IL-1 and IL-6 were decreased and anti-inflammatory cytokines IL-10 and TGF-beta were increased after treatment with PL compared to that in the TNBS group. pl 154-156 transforming growth factor alpha Rattus norvegicus 109-117 32163062-4 2020 By taking advantage of the intense and long-lived PL of the nanoprobes, the short-lived background autofluorescence can be completely eliminated, which enables the sensitive detection of beta-hCG with a linear range of 0-10 ng mL-1 and a detection limit down to 6.1 pg mL-1, approximately two orders of magnitude improvement relative to that of a commercial beta-hCG assay kit. pl 50-52 L1 cell adhesion molecule Mus musculus 269-273 31265249-8 2019 Relying on the enhancement of PL intensity via cation exchange, the Cys- and Thr-capped CIS/ZnS QDs can sense Cd2+ sensitively. pl 30-32 CD2 molecule Homo sapiens 110-113 32265729-0 2020 Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration. pl 40-42 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 14-24 32265729-6 2020 We found that 5% PL increased rMSCs migration, and this effect was blocked by the addition of the BK channel selective antagonist Iberiotoxin (IBTX). pl 17-19 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 98-108 32250253-5 2020 Using an in vitro model of wound healing, we investigated the effect of PL-treated T cells on fibroblast proliferation and production of fibronectin and type-1 collagen as well as keratinocyte migration. pl 72-74 fibronectin 1 Homo sapiens 137-148 32250253-6 2020 RESULTS: PL induced T lymphocyte proliferation and CD69 expression, and promoted a transient upregulation of IFN-gamma and TNF-alpha. pl 9-11 CD69 molecule Homo sapiens 51-55 32250253-6 2020 RESULTS: PL induced T lymphocyte proliferation and CD69 expression, and promoted a transient upregulation of IFN-gamma and TNF-alpha. pl 9-11 interferon gamma Homo sapiens 109-118 32250253-6 2020 RESULTS: PL induced T lymphocyte proliferation and CD69 expression, and promoted a transient upregulation of IFN-gamma and TNF-alpha. pl 9-11 tumor necrosis factor Homo sapiens 123-132 32250253-7 2020 However, later on, PL enhanced the number of CD25+ T cells releasing TGF-beta and expressing Foxp3 RNA, which was accompanied by a suppression in the level of type 1 cytokines. pl 19-21 interleukin 2 receptor subunit alpha Homo sapiens 45-49 32250253-7 2020 However, later on, PL enhanced the number of CD25+ T cells releasing TGF-beta and expressing Foxp3 RNA, which was accompanied by a suppression in the level of type 1 cytokines. pl 19-21 transforming growth factor alpha Homo sapiens 69-77 32250253-7 2020 However, later on, PL enhanced the number of CD25+ T cells releasing TGF-beta and expressing Foxp3 RNA, which was accompanied by a suppression in the level of type 1 cytokines. pl 19-21 forkhead box P3 Homo sapiens 93-98 32250253-8 2020 In the in vitro model, supernatants of PL-treated T cells positively affected the reparative capacity of human keratinocytes and induced fibroblast proliferation and production of fibronectin and type-1 collagen. pl 39-41 fibronectin 1 Homo sapiens 180-191 31991927-8 2020 We also pointed out that the PL-induced generation of intracellular ROS (reactive oxygen species) via NOX4 (NADPH oxidase 4) is necessary for the activation of TRPM2 and the resulting Ca2+ entry from the extracellular space. pl 29-31 NADPH oxidase 4 Homo sapiens 102-106 31991927-8 2020 We also pointed out that the PL-induced generation of intracellular ROS (reactive oxygen species) via NOX4 (NADPH oxidase 4) is necessary for the activation of TRPM2 and the resulting Ca2+ entry from the extracellular space. pl 29-31 NADPH oxidase 4 Homo sapiens 108-123 31991927-8 2020 We also pointed out that the PL-induced generation of intracellular ROS (reactive oxygen species) via NOX4 (NADPH oxidase 4) is necessary for the activation of TRPM2 and the resulting Ca2+ entry from the extracellular space. pl 29-31 transient receptor potential cation channel subfamily M member 2 Homo sapiens 160-165 31675958-8 2019 Different PL preparations were then applied in cartilage culture with interleukin-1 beta and cultured for 10 days. pl 10-12 interleukin-1 beta Equus caballus 70-88 31486116-7 2019 Fitting the MSTN-F94L variant as a random effect, the genomic prediction accuracies for birth weight increased by 2.7% in PL, by 2.2% in AL and by 3.2% in MB. pl 122-124 myostatin Bos taurus 12-16 31409470-8 2019 Under optimal conditions, this probe exhibited a good linear relationship between PL response and PO43- concentration in the range from 7.0 to 30.0 muM with a limit of detection of 50 nM. pl 82-84 latexin Homo sapiens 148-151 31274212-3 2019 PL signals of the cage can be switched and modulated by adding or retracting Fc derivatives or converting TTF into different oxidation states through chemical or photochemical pathways. pl 0-2 ras homolog family member H Homo sapiens 106-109 31360967-4 2019 The thermally coupled 1E(1D)/3T2(3F) states of Cr4+ or the 2E(2G)/4T2(4F) states of Cr3+ were revealed as competitive energy level pairs suitable for PL lifetime based temperature sensing. pl 150-152 teratocarcinoma-derived growth factor 1 pseudogene 4 Homo sapiens 47-50 31360967-4 2019 The thermally coupled 1E(1D)/3T2(3F) states of Cr4+ or the 2E(2G)/4T2(4F) states of Cr3+ were revealed as competitive energy level pairs suitable for PL lifetime based temperature sensing. pl 150-152 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 84-87 31360967-5 2019 Quadrivalent Cr4+ had a particular PL lifetime ratio of 1E(1D)/3T2(3F) up to 103, which was much higher than that (101) of trivalent Cr3+:2E(2G)/4T2(4F). pl 35-37 teratocarcinoma-derived growth factor 1 pseudogene 4 Homo sapiens 13-16 31265249-10 2019 Moreover, intercellular Cd2+ can also be evaluated by the bright PL from the QDs, and the QDs can achieve multicolor imaging. pl 65-67 CD2 molecule Homo sapiens 24-27 30825581-9 2019 Paired stimulation of mPFC and whiskers revealed an inhibitory effect at short intervals (<100 ms), which was mediated by ZI inhibitory neurons since PL stimulation induced response facilitation in the majority of ZI neurons (42%) and muscimol injection into ZI nucleus reduced inhibitory effects, suggesting that the mPFC may inhibit the POm neurons by activation of GABAergic ZI neurons. pl 153-155 complement factor properdin Mus musculus 22-26 30825581-9 2019 Paired stimulation of mPFC and whiskers revealed an inhibitory effect at short intervals (<100 ms), which was mediated by ZI inhibitory neurons since PL stimulation induced response facilitation in the majority of ZI neurons (42%) and muscimol injection into ZI nucleus reduced inhibitory effects, suggesting that the mPFC may inhibit the POm neurons by activation of GABAergic ZI neurons. pl 153-155 complement factor properdin Mus musculus 321-325 31089001-9 2019 The in situ expressions of type II Collagen (Col2) and matrix metalloproteinase 13 (Mmp13) in the arthritic cartilage was abnormal and was restored by PL. pl 151-153 matrix metallopeptidase 13 Homo sapiens 55-82 31089001-9 2019 The in situ expressions of type II Collagen (Col2) and matrix metalloproteinase 13 (Mmp13) in the arthritic cartilage was abnormal and was restored by PL. pl 151-153 matrix metallopeptidase 13 Homo sapiens 84-89 31089001-10 2019 In vitro, PL significantly restored tumor necrosis factor alpha (TNF-alpha)-suppressed anabolic gene expression (Col2 and aggrecan) and TNF-alpha-increased catabolic gene expression (Col10, Mmp13, Adamts5, and Adamts9) in chondrocytes. pl 10-12 tumor necrosis factor Homo sapiens 36-63 31089001-10 2019 In vitro, PL significantly restored tumor necrosis factor alpha (TNF-alpha)-suppressed anabolic gene expression (Col2 and aggrecan) and TNF-alpha-increased catabolic gene expression (Col10, Mmp13, Adamts5, and Adamts9) in chondrocytes. pl 10-12 tumor necrosis factor Homo sapiens 65-74 31089001-10 2019 In vitro, PL significantly restored tumor necrosis factor alpha (TNF-alpha)-suppressed anabolic gene expression (Col2 and aggrecan) and TNF-alpha-increased catabolic gene expression (Col10, Mmp13, Adamts5, and Adamts9) in chondrocytes. pl 10-12 matrix metallopeptidase 13 Homo sapiens 190-195 31089001-10 2019 In vitro, PL significantly restored tumor necrosis factor alpha (TNF-alpha)-suppressed anabolic gene expression (Col2 and aggrecan) and TNF-alpha-increased catabolic gene expression (Col10, Mmp13, Adamts5, and Adamts9) in chondrocytes. pl 10-12 ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens 197-204 31089001-10 2019 In vitro, PL significantly restored tumor necrosis factor alpha (TNF-alpha)-suppressed anabolic gene expression (Col2 and aggrecan) and TNF-alpha-increased catabolic gene expression (Col10, Mmp13, Adamts5, and Adamts9) in chondrocytes. pl 10-12 ADAM metallopeptidase with thrombospondin type 1 motif 9 Homo sapiens 210-217 31089001-12 2019 This study provides certain knowledge of anti-OA effect and TNF signaling-related mechanism of PL, placing it as a promising and alternative option for OA therapy in the future. pl 95-97 tumor necrosis factor Homo sapiens 60-63 30622945-9 2018 Accordingly, PL induced in quiescent cells activation of the proliferation-related pathways ERK, Akt, and STAT-3 and expression of Cyclin D1. pl 13-15 mitogen-activated protein kinase 1 Homo sapiens 92-95 30697894-6 2019 The granular-like BaB2 O4 :Eu3+ red phosphor prepared by this two-step method exhibited stronger PL intensity and better red color purity than when prepared by a solid-state method. pl 97-99 immunoglobulin kappa variable 5-2 Homo sapiens 18-22 30104096-15 2018 PL supplementation of dMSCs improved AKT signaling, but they were resistant to FGF2 activation of extracellular signal-regulated protein kinases 1 and 2. pl 0-2 AKT serine/threonine kinase 1 Homo sapiens 37-40 30104096-19 2018 Thus, PL supplementation strategies may improve AKT signaling, which could be important to MSC survival in cellular therapies. pl 6-8 AKT serine/threonine kinase 1 Homo sapiens 48-51 30970613-3 2019 PL exerted a protective effect on HUVEC in an inflammatory milieu by inhibiting IL-1alpha-activated NF-kappaB pathway and by inducing the secretion of PGE2, a pro-resolving molecule in the wound microenvironment. pl 0-2 interleukin 1 alpha Homo sapiens 80-89 30970613-3 2019 PL exerted a protective effect on HUVEC in an inflammatory milieu by inhibiting IL-1alpha-activated NF-kappaB pathway and by inducing the secretion of PGE2, a pro-resolving molecule in the wound microenvironment. pl 0-2 nuclear factor kappa B subunit 1 Homo sapiens 100-109 32186019-7 2019 We examined the effect of PL, RG, and PF (PRP), a most effective herbal formula deduced from constitutive ingredient herbs of Antai Yin which is composed of PRP, on the leukemia inhibitory factor (LIF) expression and endometrial receptivity. pl 26-28 LIF interleukin 6 family cytokine Homo sapiens 169-195 30622945-9 2018 Accordingly, PL induced in quiescent cells activation of the proliferation-related pathways ERK, Akt, and STAT-3 and expression of Cyclin D1. pl 13-15 cyclin D1 Homo sapiens 131-140 30622945-10 2018 Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8. pl 10-12 interleukin 1 alpha Homo sapiens 99-108 30622945-10 2018 Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8. pl 10-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-127 30622945-10 2018 Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8. pl 10-12 interleukin 6 Homo sapiens 180-184 30622945-10 2018 Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8. pl 10-12 C-X-C motif chemokine ligand 8 Homo sapiens 190-194 29980062-4 2018 The transition of electrons localized in different sized sub-domain of the sp2 bonded carbons having different values of highest occupied molecular orbital (HOMO) -lowest unoccupied molecular orbital (LUMO) gap may likely to be responsible for the observed PL emission in rG1 and rG2 at different excitation wavelengths. pl 257-259 myosin light chain, phosphorylatable, fast skeletal muscle Rattus norvegicus 280-283 30622945-9 2018 Accordingly, PL induced in quiescent cells activation of the proliferation-related pathways ERK, Akt, and STAT-3 and expression of Cyclin D1. pl 13-15 AKT serine/threonine kinase 1 Homo sapiens 97-100 30622945-9 2018 Accordingly, PL induced in quiescent cells activation of the proliferation-related pathways ERK, Akt, and STAT-3 and expression of Cyclin D1. pl 13-15 signal transducer and activator of transcription 3 Homo sapiens 106-112 30429648-8 2018 Among the CTB-positive cells, 2.6% in the PL, 4.2% in the BLA, and 1.1% in the vHIP were co-labeled by c-Fos, whereas among c-Fos-positive cells, 7.7% in the PL, 19.8% in the BLA, and 8.5% in the vHIP were co-labeled with CTB. pl 42-44 phosphate cytidylyltransferase 1, choline, beta isoform Mus musculus 10-13 30429648-8 2018 Among the CTB-positive cells, 2.6% in the PL, 4.2% in the BLA, and 1.1% in the vHIP were co-labeled by c-Fos, whereas among c-Fos-positive cells, 7.7% in the PL, 19.8% in the BLA, and 8.5% in the vHIP were co-labeled with CTB. pl 42-44 FBJ osteosarcoma oncogene Mus musculus 103-108 30254326-5 2018 The results show that PL contains a high amount of NPY, which is in part also excreted by ASCs when stimulated with PL. pl 22-24 neuropeptide Y Homo sapiens 51-54 30254326-5 2018 The results show that PL contains a high amount of NPY, which is in part also excreted by ASCs when stimulated with PL. pl 116-118 neuropeptide Y Homo sapiens 51-54 30254326-6 2018 The protein levels of the three main NPY subtype receptors (Y1, Y2, Y5) are unaltered by stimulation of ASCs with PL, but their inhibition through selective pharmacological antagonists, considerably enhances migration, and a parallel reduction of angiogenic features of ASCs including decrease in VEGF mRNA and intracellular calcium levels, both downstream targets of NPY. pl 114-116 RNA, Ro60-associated Y1 Homo sapiens 60-70 30254326-8 2018 Our data highlight the presence of NPY in PL preparations and its peripheral effects on adipose progenitors. pl 42-44 neuropeptide Y Homo sapiens 35-38 30031163-6 2018 Moreover, the release of the chemotactic and pro-angiogenic growth factors (GFs) (PDGF and VEGF) from the PL-laden hydrogels showed an improved sustained profile proportional to the amount of incorporated CNCs. pl 106-108 vascular endothelial growth factor A Homo sapiens 91-95 29341933-7 2018 Cells were able to proliferate over time and an up-regulation of tenogenic genes (SCX, COL1A1 and TNC) was observed, suggesting that PL patches may modify the behavior of hTDCs. pl 133-135 scleraxis bHLH transcription factor Homo sapiens 82-85 29620264-6 2018 The expression levels of caspase-3/9 were significantly upregulated within PL-PTX-treated ovarian cancer cells. pl 75-77 caspase 3 Mus musculus 25-34 29624869-4 2018 The BAz monomer showed slight PL in the dilute solution, and aggregation-induced emission (AIE) was detected. pl 30-32 par-3 family cell polarity regulator Homo sapiens 4-7 29341933-7 2018 Cells were able to proliferate over time and an up-regulation of tenogenic genes (SCX, COL1A1 and TNC) was observed, suggesting that PL patches may modify the behavior of hTDCs. pl 133-135 collagen type I alpha 1 chain Homo sapiens 87-93 29341933-7 2018 Cells were able to proliferate over time and an up-regulation of tenogenic genes (SCX, COL1A1 and TNC) was observed, suggesting that PL patches may modify the behavior of hTDCs. pl 133-135 tenascin C Homo sapiens 98-101 29341933-12 2018 Remarkably, PL patches supported the activity of native tendon cells by up-regulating tenogenic genes and enabling the deposition of ECM proteins. pl 12-14 multimerin 1 Homo sapiens 133-136 28140474-12 2017 PL significantly prevented the increase in EGF production at tested times. pl 0-2 epidermal growth factor Homo sapiens 43-46 29052350-8 2018 Moreover, in cultured cartilage cells, PL induced a hypoxia-inducible factor (HIF-1) alpha increase, its nuclear relocation and the binding to HIF-1 responsive elements. pl 39-41 hypoxia inducible factor 1 subunit alpha Homo sapiens 78-90 29052350-8 2018 Moreover, in cultured cartilage cells, PL induced a hypoxia-inducible factor (HIF-1) alpha increase, its nuclear relocation and the binding to HIF-1 responsive elements. pl 39-41 hypoxia inducible factor 1 subunit alpha Homo sapiens 78-83 28365518-8 2017 The result from the lymphocyte immunophenotyping of BLV-infected cows with PL was an increase in B cells, mainly B CD5+ CD11b+, due to the apoptosis inhibition. pl 75-77 CD5 molecule Bos taurus 115-118 28365518-8 2017 The result from the lymphocyte immunophenotyping of BLV-infected cows with PL was an increase in B cells, mainly B CD5+ CD11b+, due to the apoptosis inhibition. pl 75-77 integrin subunit alpha M Bos taurus 120-125 28437081-6 2017 Moreover, along with the Gd3+ PL intensity enhancement, a linear correlation was revealed between the increase in decay times for the Gd3+6P7/2-emitting state and the amount of silicon. pl 30-32 GRDX Homo sapiens 25-28 28437081-6 2017 Moreover, along with the Gd3+ PL intensity enhancement, a linear correlation was revealed between the increase in decay times for the Gd3+6P7/2-emitting state and the amount of silicon. pl 30-32 GRDX Homo sapiens 134-137 28437081-7 2017 It is then suggested that the improved PL properties of gadolinium(III) originate from the increased UV transparency of the host and the consequent precluding of a nonradiative energy transfer from Gd3+ to the matrix. pl 39-41 GRDX Homo sapiens 198-201 29683102-5 2018 Insulin was used as the model protein; insulin-phospholipid (PL) was prepared to increase drug lipophilicity and compatibility with lipid excipients. pl 61-63 insulin Homo sapiens 39-46 28488384-3 2017 Herein, through a novel, eco-friendly, and one-step route, PMV-derived PL polymers can be fabricated with the highest quantum yield of 87% among water-soluble nonconjugated PL polymers ever reported. pl 71-73 ciliogenesis associated kinase 1 Homo sapiens 25-28 28140474-13 2017 PL significantly reduced the p53 (-80%), p21 (-84%), and Ki-67 (-48%) positive cells. pl 0-2 tumor protein p53 Homo sapiens 29-32 28140474-13 2017 PL significantly reduced the p53 (-80%), p21 (-84%), and Ki-67 (-48%) positive cells. pl 0-2 H3 histone pseudogene 16 Homo sapiens 41-44 32903287-4 2016 Moreover, we found that the near band edge emission feature at hvEM = 3.2 eV gains relative intensity with regard to the PL emission features in the visible light region. pl 121-123 TNF receptor superfamily member 14 Homo sapiens 63-67 27841298-8 2016 Furthermore, PL may reduce amino acid transport and cell proliferation through the depression of mTOR pathway. pl 13-15 mechanistic target of rapamycin kinase Sus scrofa 97-101 27973912-5 2016 Time-resolved PL from individual FA1-xMAxPbI3 nanorods demonstrates that lifetimes of mixed cation FA1-xMAxPbI3 nanorods are longer than those of the pure FAPbI3 or MAPbI3 nanorods, and the FA0.4MA0.6PbI3 displays the longest average PL lifetime of about 2 mus. pl 14-16 FA complementation group A Homo sapiens 33-36 27973912-5 2016 Time-resolved PL from individual FA1-xMAxPbI3 nanorods demonstrates that lifetimes of mixed cation FA1-xMAxPbI3 nanorods are longer than those of the pure FAPbI3 or MAPbI3 nanorods, and the FA0.4MA0.6PbI3 displays the longest average PL lifetime of about 2 mus. pl 14-16 FA complementation group A Homo sapiens 99-102 25657071-2 2015 In this study, lithocholic acid (LCA), a potent anti-cancer drug, is converted to two forms of poly(ethyleneglycol) (PEG) conjugates, viz., PEG-LCA (PL) and lactobionic acid (LBA) conjugated PEG-LCA (LPL). pl 149-151 lipoprotein lipase Homo sapiens 200-203 27153064-5 2016 Screening of 324 pure compounds and 480 crude extracts from Chinese medicinal herbs resulted in the identification of Paeonia lactiflora Pall (PL) extract and the active component 1,2,3,4,6-penta-O-galloyl-beta-d-glucopyranoside (PGG) as a GNMT inducer. pl 143-145 glycine N-methyltransferase Homo sapiens 240-244 27153064-6 2016 Purified PL extract and PGG induced GNMT mRNA and protein expression in Huh7 human hepatoma cells and in xenograft tumors. pl 9-11 glycine N-methyltransferase Homo sapiens 36-40 26709648-6 2016 The inhibition of the PI3kinase/AKT pathway with the specific inhibitor wortmannin, decreases PL-induced cell migration but not proliferation. pl 94-96 AKT serine/threonine kinase 1 Homo sapiens 32-35 26709648-9 2016 GMP-grade PL preparations positively influence in vitro biological effects of TFs representing a suitable and safer alternative to FBS. pl 10-12 5'-nucleotidase, cytosolic II Homo sapiens 0-3 26413793-8 2015 Cells had a low baseline expression of ALP and GAG, but increased expression of total collagen when induced by the ligament and tenogenic growth factor fibroblast growth factor 2 (FGF-2), especially when cultured in the presence of PL (p < 0.01) instead of FBS (p < 0.05). pl 232-234 fibroblast growth factor 2 Homo sapiens 152-178 26413793-8 2015 Cells had a low baseline expression of ALP and GAG, but increased expression of total collagen when induced by the ligament and tenogenic growth factor fibroblast growth factor 2 (FGF-2), especially when cultured in the presence of PL (p < 0.01) instead of FBS (p < 0.05). pl 232-234 fibroblast growth factor 2 Homo sapiens 180-185 26263542-7 2015 RESULTS: The proliferation rates of DPSCs and SCAP significantly increased when cells were treated with 5% PL (7X doubling time) as compared to FBS. pl 107-109 SREBF chaperone Homo sapiens 46-50 26263542-8 2015 5% PL also enhanced mineralized differentiation of DPSCs and SCAP, as indicated by the measurement of alkaline phosphatase activity, osteocalcin and osteopontin, calcium deposition and q-PCR. pl 3-5 SREBF chaperone Homo sapiens 61-65 26263542-8 2015 5% PL also enhanced mineralized differentiation of DPSCs and SCAP, as indicated by the measurement of alkaline phosphatase activity, osteocalcin and osteopontin, calcium deposition and q-PCR. pl 3-5 bone gamma-carboxyglutamate protein Homo sapiens 133-144 26263542-8 2015 5% PL also enhanced mineralized differentiation of DPSCs and SCAP, as indicated by the measurement of alkaline phosphatase activity, osteocalcin and osteopontin, calcium deposition and q-PCR. pl 3-5 secreted phosphoprotein 1 Homo sapiens 149-160 26588227-2 2015 Poly-L-lysine (PL) is a basic polypeptide identified for its role in the activation of CaSR through allosteric binding. pl 15-17 calcium sensing receptor Homo sapiens 87-91 26588227-6 2015 On the other hand, the gene expression of pro-inflammatory cytokines TNF-alpha, IL-6, and IL-1beta was inhibited by PL supplementation. pl 116-118 tumor necrosis factor Homo sapiens 69-78 26588227-6 2015 On the other hand, the gene expression of pro-inflammatory cytokines TNF-alpha, IL-6, and IL-1beta was inhibited by PL supplementation. pl 116-118 interleukin 6 Homo sapiens 80-84 26588227-6 2015 On the other hand, the gene expression of pro-inflammatory cytokines TNF-alpha, IL-6, and IL-1beta was inhibited by PL supplementation. pl 116-118 interleukin 1 beta Homo sapiens 90-98 26588227-9 2015 The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration. pl 192-194 tumor necrosis factor Mus musculus 71-80 26588227-9 2015 The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration. pl 192-194 interleukin 6 Mus musculus 82-86 26588227-9 2015 The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration. pl 192-194 interleukin 17A Mus musculus 88-104 26588227-9 2015 The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration. pl 192-194 interleukin 1 beta Mus musculus 110-118 26588227-11 2015 In the present study, we provide evidence that PL exerts anti-inflammatory effects on the gut system, which is primarily mediated by allosteric ligand activation of CaSR. pl 47-49 calcium sensing receptor Homo sapiens 165-169 25669753-5 2015 Hippocampal neurons projecting to either PL or BA exhibited similar degrees of context-dependent Fos expression; there were more Fos-positive neurons in each area after the renewal, as opposed, to suppression of fear. pl 41-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 97-100 25669753-5 2015 Hippocampal neurons projecting to either PL or BA exhibited similar degrees of context-dependent Fos expression; there were more Fos-positive neurons in each area after the renewal, as opposed, to suppression of fear. pl 41-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 129-132 24254232-4 2014 Very narrow and symmetric PL emission was observed in the yellow region for core-shell CdS/ZnS. pl 26-28 CDP-diacylglycerol synthase 1 Homo sapiens 87-90 25073002-6 2015 The COL3A1 AA genotype was, however, significantly (p = 0.036) over-represented in the PL ACL group (9.9%, n = 9) when compared to the PL control (CON) group (2.8%, n = 4). pl 87-89 collagen type III alpha 1 chain Homo sapiens 4-10 25299186-8 2014 CONCLUSION: This meta-analysis suggested that GnRH-ant can reduce the incidence of PL and increase the CPR when used in COS/IUI cycles, and it was especially useful for non-PCOS patients. pl 83-85 gonadotropin releasing hormone 1 Homo sapiens 46-50 25130438-12 2014 The previously reported biological activity of pL and the presence of CYP11A1 in skin suggest that this pathway may serve to produce biologically active products from L3, emphasizing a novel role of CYP11A1 in sterol metabolism. pl 47-49 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 199-206 24992758-8 2014 Serum levels of TNF-alpha, IL-2, and IFN-gamma, frequencies of CD4 + and CD8+ T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU+PL or 5-FU+PTM compared with mice treated with 5-FU alone (P < 0.05). pl 195-197 tumor necrosis factor Mus musculus 16-25 24720766-5 2014 We demonstrated that, in MSCs, PL induced nuclear factor kappaB (NF-kappaB) activation, expression of COX-2 and mPGE synthase, and PGE2 production; in an inflammatory microenvironment, PL increased the inflammatory response and promoted the secretion of the proinflammatory cytokine IL-6. pl 31-33 cytochrome c oxidase II, mitochondrial Mus musculus 102-107 24720766-5 2014 We demonstrated that, in MSCs, PL induced nuclear factor kappaB (NF-kappaB) activation, expression of COX-2 and mPGE synthase, and PGE2 production; in an inflammatory microenvironment, PL increased the inflammatory response and promoted the secretion of the proinflammatory cytokine IL-6. pl 31-33 interleukin 6 Mus musculus 283-287 25013939-7 2014 Moreover, electrophysiological recordings demonstrated PL-mediated inhibition of LPS or Tg-induced currents that were TRPC1-dependent. pl 55-57 transient receptor potential cation channel subfamily C member 1 Homo sapiens 118-123 24992758-8 2014 Serum levels of TNF-alpha, IL-2, and IFN-gamma, frequencies of CD4 + and CD8+ T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU+PL or 5-FU+PTM compared with mice treated with 5-FU alone (P < 0.05). pl 195-197 interferon gamma Mus musculus 37-46 24430559-4 2014 Herein, a novel polymeric nanoparticle delivery system composed of heparin and e-poly-L-lysine (PL) was prepared for control release of nerve growth factor (NGF) and basic fibroblast growth factor (bFGF). pl 96-98 fibroblast growth factor 2 Homo sapiens 166-196 24430559-4 2014 Herein, a novel polymeric nanoparticle delivery system composed of heparin and e-poly-L-lysine (PL) was prepared for control release of nerve growth factor (NGF) and basic fibroblast growth factor (bFGF). pl 96-98 fibroblast growth factor 2 Homo sapiens 198-202 24012435-3 2013 We demonstrated that PL stimulation induces a transient increase of the inflammatory response in quiescent human osteoblasts, via NF-kB activation, COX-2 induction, PGE2 production and secretion of pro-inflammatory cytokines. pl 21-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 148-153 24077221-11 2014 PTC single focus in PL is very rare and only individual experiences can be discussed regarding the extent of the surgery. pl 20-22 coiled-coil domain containing 6 Homo sapiens 0-3 24012435-7 2013 These results correlated with up-regulation of the proliferative and survival pathways ERKs and Akt and with cell cycle re-activation via induction of CyclinD1 and phosphorylation of Rb, following PL stimulation. pl 197-199 cyclin D1 Homo sapiens 151-159 24266258-5 2013 In the range of 0.5-15 ng/mL for AFP or CEA (or 0.5-15 U/mL for CA125 or CA19-9), the apparent linear relations between the PL enhancements and the concentrations of HCC markers offered simple standard curve for HCC detection in serum samples, indicating that the PL-enhanced antibody-ZnO arrays could be utilized in early clinical screening. pl 124-126 alpha fetoprotein Homo sapiens 33-36 24266258-5 2013 In the range of 0.5-15 ng/mL for AFP or CEA (or 0.5-15 U/mL for CA125 or CA19-9), the apparent linear relations between the PL enhancements and the concentrations of HCC markers offered simple standard curve for HCC detection in serum samples, indicating that the PL-enhanced antibody-ZnO arrays could be utilized in early clinical screening. pl 124-126 CEA cell adhesion molecule 3 Homo sapiens 40-43 24266258-5 2013 In the range of 0.5-15 ng/mL for AFP or CEA (or 0.5-15 U/mL for CA125 or CA19-9), the apparent linear relations between the PL enhancements and the concentrations of HCC markers offered simple standard curve for HCC detection in serum samples, indicating that the PL-enhanced antibody-ZnO arrays could be utilized in early clinical screening. pl 124-126 mucin 16, cell surface associated Homo sapiens 64-69 24070307-8 2013 Interestingly, interchain interactions lead only to about a 30% drop in the PL ratio, suggesting that the MEH-PPV pi-stacks--and strongly disordered HJ-aggregates in general--can masquerade as single (elongated) chains. pl 76-78 epoxide hydrolase 1 Homo sapiens 106-109 23893408-9 2013 Our findings identify a novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. pl 143-145 granzyme B Homo sapiens 30-33 23893408-9 2013 Our findings identify a novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. pl 143-145 intersectin 1 Homo sapiens 37-41 23893408-9 2013 Our findings identify a novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. pl 143-145 mitogen-activated protein kinase 1 Homo sapiens 64-67 23893408-9 2013 Our findings identify a novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. pl 143-145 ETS transcription factor ELK1 Homo sapiens 74-79 24300511-4 2013 We found that carboxylesterase (CES), especially the rat CES1 isozyme, Hydrolase A, is expressed in rat skin and that the hydrolysis of p-nitrophenyl acyl derivatives and caproyl-propranolol (PL) was 20-fold lower in the 9000g supernatant fraction of skin homogenate than in liver microsomes. pl 192-194 carboxylesterase 1E Rattus norvegicus 57-61 23274196-2 2013 The LPD method could embed a monoclonal antibody of C-reactive protein (Anti-CRP), which is mixed with poly(l-lysine) (PL) as an organic binder, on/in titanium oxide thin layer deposited onto a surface plasmon resonance (SPR) sensing chip (F(Anti-CRP-PL)), allowing simple immobilization of anti-CRP capable of CRP detection. pl 119-121 C-reactive protein Homo sapiens 52-70 22465169-5 2012 Our findings also showed that electrical stimulation of PL (100 muA) suppressed morphine-induced CPP that reveals impaired learning and memory formation in the process of conditioning through the blocking connection from the hippocampus to the prelimbic cortex of mPFC. pl 56-58 complement factor properdin Mus musculus 264-268 23939464-5 2013 Based on the linear relationship (R = -0.9994) between the ratiometric PL intensity (IQD2/IQD1) and the molar concentration of 5-FU (0-1 muM), a ratiometric PL sensor for 5-FU was achieved and displays a low limit of detection (20 nM). pl 71-73 latexin Homo sapiens 137-140 22698936-6 2012 The osteogenic differentiation of the seeded hASCs was observed earlier for the PL-loaded constructs, as shown by the earlier alkaline phosphatase peak and calcium detection and stronger Runx2 expression at day 7 of culture, in comparison with the control scaffolds. pl 80-82 RUNX family transcription factor 2 Homo sapiens 187-192 22698936-7 2012 Osteocalcin gene expression was upregulated in presence of PL during all culture period, which indicates an enhanced osteogenic induction. pl 59-61 bone gamma-carboxyglutamate protein Homo sapiens 0-11