PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8875598-0	1996	Pharmacological characteristics of BDTI, a new isoquinoline-derived beta 2-adrenoceptor agonist, in canine trachea and rat heart.	isoquinoline	47-59	beta-2 adrenergic receptor	Canis lupus familiaris	68-87
8630091-1	1996	Isoquinoline derivatives exert 1-methyl-4-phenylpyridinium (MPP+)-like activity as inhibitors of complex I and alpha-ketoglutarate dehydrogenase activity in rat brain mitochondrial fragments.	isoquinoline	0-12	oxoglutarate dehydrogenase	Rattus norvegicus	111-144
8691425-5	1996	The resulting structure-activity relationships seem to validate the mechanism of action of these inhibitors as analogs of a pro-C-8 high-energy intermediate and delineate the minimal requirements for the design of efficient isoquinoline-based, or simplified, OSC inhibitors.	isoquinoline	224-236	lanosterol synthase	Homo sapiens	259-262
8839983-8	1996	The very potent isoquinoline-derived cAK inhibitors found here involve substitution of the N-containing isoquinoline ring system and these inhibitors show high specificity for cAK.	isoquinoline	16-28	cyclin-dependent kinase 7	Rattus norvegicus	37-40
8839983-8	1996	The very potent isoquinoline-derived cAK inhibitors found here involve substitution of the N-containing isoquinoline ring system and these inhibitors show high specificity for cAK.	isoquinoline	16-28	cyclin-dependent kinase 7	Rattus norvegicus	176-179
8575032-5	1995	Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridazine, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity.	isoquinoline	120-132	5-hydroxytryptamine receptor 3A	Rattus norvegicus	151-165
2037868-1	1991	Kinetic analysis has shown that isoquinoline, papaverine and berberine act as reversible competitive inhibitors to muscle lactate dehydrogenase and mitochondrial malate dehydrogenase with respect to the coenzyme NADH.	isoquinoline	32-44	malic enzyme 2	Homo sapiens	162-182
1473250-1	1992	Promotion of "initiated" JB6 epidermal cells to the tumor phenotype can be effected by 12-O-tetradecanoylphorbol-13-acetate treatment, by stimulation of epidermal growth factor (EGF) receptor activity with EGF or transforming growth factor alpha and by exposure to the isoquinoline derivative H7.	isoquinoline	269-281	epidermal growth factor	Homo sapiens	178-181
7542903-3	1995	Peripheral BZ receptors (PBR) are composed of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier, with molecular weights of 18, 32, and 30 kDa, respectively.	isoquinoline	65-77	translocator protein	Homo sapiens	0-23
7542903-3	1995	Peripheral BZ receptors (PBR) are composed of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier, with molecular weights of 18, 32, and 30 kDa, respectively.	isoquinoline	65-77	translocator protein	Homo sapiens	25-28
7662887-0	1995	Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	isoquinoline	51-63	oxoglutarate dehydrogenase	Rattus norvegicus	14-47
7841044-7	1995	In contrast, both the isoquinoline carboxamide PK11195 and the benzodiazepine Ro 5-4864 ligands, displaying a high affinity for the MBR, did affect ALA-mediated phototoxicity, each markedly increasing the EC50 for cell photodestruction and thus exerting a photoprotective effect.	isoquinoline	22-34	translocator protein	Rattus norvegicus	132-135
7516040-0	1994	The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells.	isoquinoline	4-16	arginine vasopressin	Rattus norvegicus	55-66
1649835-4	1991	Photolabeling with an isoquinoline ligand, [3H]PK 14105, identifies a 17-kDa protein, the PBR isoquinoline binding protein (PBR/IBP), in both species.	isoquinoline	22-34	translocator protein	Bos taurus	90-93
1649835-4	1991	Photolabeling with an isoquinoline ligand, [3H]PK 14105, identifies a 17-kDa protein, the PBR isoquinoline binding protein (PBR/IBP), in both species.	isoquinoline	22-34	translocator protein	Bos taurus	124-127
1649835-4	1991	Photolabeling with an isoquinoline ligand, [3H]PK 14105, identifies a 17-kDa protein, the PBR isoquinoline binding protein (PBR/IBP), in both species.	isoquinoline	22-34	translocator protein	Bos taurus	128-131
1649835-5	1991	To further elucidate the role of the PBR/IBP in determining PBR benzodiazepine and isoquinoline binding characteristics, the bovine PBR/IBP was cloned and expressed.	isoquinoline	83-95	translocator protein	Bos taurus	136-139
2037868-5	1991	A fluorimetric analysis of the binding of the three alkaloids show that the dissociation constants (Kd) for malate dehydrogenase are 2.8 microM (berberine), 46 microM (papaverine) and 86 microM (isoquinoline); the corresponding values for lactate dehydrogenase are 3.1 microM, 52 microM and 114 microM.	isoquinoline	195-207	malic enzyme 2	Homo sapiens	108-128
1883525-8	1991	Inhibition of PKC by the isoquinoline derivative H7 abolishes induction of M-CSF by M-CSF.	isoquinoline	25-37	proline rich transmembrane protein 2	Homo sapiens	14-17
1883525-8	1991	Inhibition of PKC by the isoquinoline derivative H7 abolishes induction of M-CSF by M-CSF.	isoquinoline	25-37	colony stimulating factor 1	Homo sapiens	75-80
1883525-8	1991	Inhibition of PKC by the isoquinoline derivative H7 abolishes induction of M-CSF by M-CSF.	isoquinoline	25-37	colony stimulating factor 1	Homo sapiens	84-89
33971490-0	2021	Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors.	isoquinoline	88-100	MAPK interacting serine/threonine kinase 1	Homo sapiens	117-123
2196173-11	1990	The results also demonstrate that the induction of Na+ influx by CSF-1 is inhibited by the protein kinase C inhibitors staurosporine and the isoquinoline derivative H7, but not by HA1004.	isoquinoline	141-153	colony stimulating factor 1	Homo sapiens	65-70
34358095-8	2021	Molecular dynamic simulations with the parallel G4 formed by a 21-nt sequence present in k-RAS gene promoter, showed that the relative spatial orientation of the two methylated quinoline/isoquinoline rings determines the ligands mode and strength of binding to G4s.	isoquinoline	187-199	KRAS proto-oncogene, GTPase	Homo sapiens	89-94
30052463-7	2018	Two isoquinoline derivatives were identified as novel ABCB1 inhibitors, one of which was a phenethylisoquinoline alkaloid, (+-)-7-benzyloxy-1-(3-benzyloxy-4-methoxyphenethyl)-1,2,3,4-tetrahydro-6-methoxy-2-methylisoquinoline oxalate.	isoquinoline	4-16	ATP binding cassette subfamily B member 1	Homo sapiens	54-59
34659902-0	2021	PTEN inhibition leads to the development of resistance to novel isoquinoline derivative TNBG-5602 in human liver cancer cells.	isoquinoline	64-76	phosphatase and tensin homolog	Homo sapiens	0-4
34920926-0	2022	Corrigendum to "Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors" (Bioorg.	isoquinoline	104-116	MAPK interacting serine/threonine kinase 1	Homo sapiens	133-139
34684878-0	2021	Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists.	isoquinoline	53-65	C-X-C motif chemokine receptor 4	Homo sapiens	72-77
34684819-3	2021	Various in vitro and in vivo studies have reported the anti-inflammatory role of berberine (BRB), an organic heteropentacyclic phytochemical and natural isoquinoline, in inhibiting NLRP3 inflammasome-dependent inflammation against many disorders.	isoquinoline	153-165	NLR family pyrin domain containing 3	Homo sapiens	181-186
3346669-7	1988	The relationship of the chemical structure of structurally related quinoline and isoquinoline derivatives to inhibition of the activity of type A or B MAO was examined.	isoquinoline	81-93	monoamine oxidase A	Homo sapiens	151-154
35597409-20	2022	Isoquinoline alkaloids, including berberine, jateorhizine, coptisine, epiberberine, columbamine, and palmatine, were substrates of hOCT1 and hOCT2, but not the indole alkaloids evodiamine and rutaecarpine.	isoquinoline	0-12	POU class 2 homeobox 2	Homo sapiens	141-146
35043181-5	2022	In the present study, the small molecule isoquinoline compound ZINC71820901 (lyn3) was obtained from the ZINC molecular library through virtual screening based on the structure of the crystal COI1-JAZ1 co-receptor and was found to act as an inhibitor of the JA signaling pathway both in Arabidopsis and tea plants.	isoquinoline	41-53	RNI-like superfamily protein	Arabidopsis thaliana	192-196
35043181-5	2022	In the present study, the small molecule isoquinoline compound ZINC71820901 (lyn3) was obtained from the ZINC molecular library through virtual screening based on the structure of the crystal COI1-JAZ1 co-receptor and was found to act as an inhibitor of the JA signaling pathway both in Arabidopsis and tea plants.	isoquinoline	41-53	jasmonate-zim-domain protein 1	Arabidopsis thaliana	197-201
35597409-20	2022	Isoquinoline alkaloids, including berberine, jateorhizine, coptisine, epiberberine, columbamine, and palmatine, were substrates of hOCT1 and hOCT2, but not the indole alkaloids evodiamine and rutaecarpine.	isoquinoline	0-12	solute carrier family 22 member 1	Homo sapiens	131-136
33100202-9	2021	Some natural/plant derived compounds including fatty acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline and indole alkaloids were also reported as potent FFAR1 agonists.	isoquinoline	110-122	free fatty acid receptor 1	Homo sapiens	173-178
3821373-5	1987	Of several compounds structurally similar to quinoline, isoquinoline noncompetitively inhibited MAO-A and -B activity.	isoquinoline	56-68	monoamine oxidase A	Homo sapiens	96-108
360759-3	1978	An isoquinoline derivative Ro 8-4650 (rac-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline hydrochloride) with dopaminergic properties was studied in a randomized crossover trial.	isoquinoline	3-15	Rac family small GTPase 1 pseudogene 4	Homo sapiens	38-43
2821259-6	1987	The R-(-) stereoisomer 11b was observed to be approximately 2.5-fold more potent than its enantiomer 11c; this is the first report of stereoselectivity in the isoquinoline series of ligands selective for the PBR.	isoquinoline	159-171	translocator protein	Homo sapiens	208-211
2892200-7	1987	After a 24 h exposure of cells kept in full-growth medium to ISq (10 micrograms ml-1), the levels of HMG-CoA reductase rose about twofold.	isoquinoline	61-64	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	101-118
5072367-0	1972	Inability of isoquinoline derivatives to inhibit virus neuraminidase activity.	isoquinoline	13-25	neuraminidase 1	Homo sapiens	55-68
33518149-10	2021	Isoquinoline alkaloid supplementation inhibited the expression of intestinal inflammatory factors, IL-6, tumor necrosis factor-like factor 1A, and inducible nitric oxide synthase under HS treatment (P < 0.05).	isoquinoline	0-12	interleukin 6	Gallus gallus	99-103
33518149-10	2021	Isoquinoline alkaloid supplementation inhibited the expression of intestinal inflammatory factors, IL-6, tumor necrosis factor-like factor 1A, and inducible nitric oxide synthase under HS treatment (P < 0.05).	isoquinoline	0-12	nitric oxide synthase 2	Gallus gallus	147-178
33378180-3	2021	Herein, we present a two-phase, fragment-based drug discovery (FBDD) effort in which we first identified isoquinoline fragments that disrupt TNFalpha ligand-receptor binding through an allosteric desymmetrization mechanism as observed in high-resolution crystal structures.	isoquinoline	105-117	tumor necrosis factor	Homo sapiens	141-149
33406435-4	2021	We identify a potent and selective small molecule isoquinoline inhibitor of SARM1 NADase that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy or mitochondrial dysfunction.	isoquinoline	50-62	sterile alpha and TIR motif containing 1	Homo sapiens	76-81
33063809-2	2020	Utilization of methoxy-substituted quinoline and isoquinoline chromophores, conformational restriction and multidentate coordination structure allow discrimination between Zn2+ and Cd2+.	isoquinoline	49-61	CD2 molecule	Homo sapiens	181-184
32614784-7	2021	The SARs analysis showed the structural difference including planar, quaternary nitrogen, and the peripheral functional groups at C-8, C-9, C-10, have strong effect on inhibition of TF activity, which provided effective methods to modify isoquinoline alkaloids for inhibiting TF activity.	isoquinoline	238-250	homeobox C8	Homo sapiens	130-133
32594322-7	2020	This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-kappaB signaling pathways, which are necessary for viral replication.	isoquinoline	5-17	mitogen-activated protein kinase kinase 7	Homo sapiens	59-62
32594322-7	2020	This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-kappaB signaling pathways, which are necessary for viral replication.	isoquinoline	5-17	mitogen-activated protein kinase 1	Homo sapiens	63-66
32594322-7	2020	This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-kappaB signaling pathways, which are necessary for viral replication.	isoquinoline	5-17	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	68-72
32594322-7	2020	This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-kappaB signaling pathways, which are necessary for viral replication.	isoquinoline	5-17	mechanistic target of rapamycin kinase	Homo sapiens	73-77
32591416-10	2020	SIGNIFICANCE STATEMENT: Robust kinetic parameters were determined for the reversible and time-dependent inhibition of CYP2C9, CYP2D6 and CYP3A4/5 activities in HLMs by major component isoquinoline alkaloids contained in the botanical natural product (NP) goldenseal.	isoquinoline	184-196	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	118-124
32591416-10	2020	SIGNIFICANCE STATEMENT: Robust kinetic parameters were determined for the reversible and time-dependent inhibition of CYP2C9, CYP2D6 and CYP3A4/5 activities in HLMs by major component isoquinoline alkaloids contained in the botanical natural product (NP) goldenseal.	isoquinoline	184-196	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	126-132
32591416-10	2020	SIGNIFICANCE STATEMENT: Robust kinetic parameters were determined for the reversible and time-dependent inhibition of CYP2C9, CYP2D6 and CYP3A4/5 activities in HLMs by major component isoquinoline alkaloids contained in the botanical natural product (NP) goldenseal.	isoquinoline	184-196	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	137-145
32454229-5	2020	Molecular docking showed that the isoquinoline moiety is embedded in a cavity surrounded by four aromatic residues of acetylcholinesterase by the pi-pi action.	isoquinoline	34-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
32723012-0	2021	Molecular modeling studies of novel naphthyridine and isoquinoline derivatives as CDK8 inhibitors.	isoquinoline	54-66	cyclin dependent kinase 8	Homo sapiens	82-86
32614784-7	2021	The SARs analysis showed the structural difference including planar, quaternary nitrogen, and the peripheral functional groups at C-8, C-9, C-10, have strong effect on inhibition of TF activity, which provided effective methods to modify isoquinoline alkaloids for inhibiting TF activity.	isoquinoline	238-250	complement C9	Homo sapiens	135-138
32614784-7	2021	The SARs analysis showed the structural difference including planar, quaternary nitrogen, and the peripheral functional groups at C-8, C-9, C-10, have strong effect on inhibition of TF activity, which provided effective methods to modify isoquinoline alkaloids for inhibiting TF activity.	isoquinoline	238-250	homeobox C10	Homo sapiens	140-144
31102120-5	2020	Results The aporphine and isoquinoline derivatives APO, C1, and A5 significantly reduced HNSCC cell viability and promoted DNA damages in these cells.	isoquinoline	26-38	aminopeptidase O (putative)	Homo sapiens	51-54
31682434-0	2020	Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.	isoquinoline	0-12	kelch like ECH associated protein 1	Homo sapiens	94-99
31682434-0	2020	Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.	isoquinoline	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
31682434-2	2020	We previously reported an isoquinoline-based NRF2 activator, but this compound showed negative logD7.4 and a -2 charge at physiological pH, which may have limited its membrane permeability.	isoquinoline	26-38	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
32503690-7	2020	These data revealed that the 18-membered ring of the bisbenzylisoquinoline alkaloids maintained the P-glycoprotein inhibitory activity, suggesting that double isoquinoline units connected by two oxygen bridges were indispensable.	isoquinoline	62-74	ATP binding cassette subfamily B member 1	Homo sapiens	100-114
32065882-2	2020	Due to our study, isoquinoline-based tetracyclic scaffold was identified as the key structural element for their anti-LSD1 activity, subtle changes of substituents attached to the core structure led to dramatic changes of the activity.	isoquinoline	18-30	lysine demethylase 1A	Homo sapiens	118-122
32065882-6	2020	These findings give the potential application of epiberberine in AML treatment, and the isoquinoline-based tetracyclic scaffold could be used for further development of LSD1 inhibitors.	isoquinoline	88-100	lysine demethylase 1A	Homo sapiens	169-173
31534655-4	2019	Optimization of hit 3 by SAR studies guided by SBDD identified indazole 38 (IC50 0.032 muM) and isoquinoline 45 (IC50 0.085 muM) as potent inhibitors of NOTUM.	isoquinoline	96-108	latexin	Homo sapiens	124-127
32382664-5	2019	Therefore, the authors of this work thought of isoquinoline based noscapine to inhibit the nsP3 protease of CHIKV.	isoquinoline	47-59	SH2 domain containing 3C	Homo sapiens	91-95
31534655-4	2019	Optimization of hit 3 by SAR studies guided by SBDD identified indazole 38 (IC50 0.032 muM) and isoquinoline 45 (IC50 0.085 muM) as potent inhibitors of NOTUM.	isoquinoline	96-108	notum, palmitoleoyl-protein carboxylesterase	Homo sapiens	153-158
30474907-0	2019	Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7.	isoquinoline	28-40	ubiquitin specific peptidase 2	Homo sapiens	97-101
30835121-2	2019	This strategy provides the synthesis of valuable SCF3-substituted quinoline and isoquinoline systems via the construction of one C(sp2)-SCF3 bond and one C-N bond within one process.	isoquinoline	80-92	Sp2 transcription factor	Homo sapiens	129-134
30835121-2	2019	This strategy provides the synthesis of valuable SCF3-substituted quinoline and isoquinoline systems via the construction of one C(sp2)-SCF3 bond and one C-N bond within one process.	isoquinoline	80-92	KIT ligand	Homo sapiens	49-52
30474907-0	2019	Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7.	isoquinoline	28-40	ubiquitin specific peptidase 7	Homo sapiens	106-110
30405404-3	2018	Berberine, a natural isoquinoline alkaloid, could modulate lipid metabolism and glucose homeostasis by regulating the expression of HNF4alpha in many metabolic diseases.	isoquinoline	21-33	hepatocyte nuclear factor 4 alpha	Homo sapiens	132-141
30419265-5	2018	The newly generated "auxiliary" stereocenter at C-1 permitted decisive NOE interactions between the isoquinoline and the naphthalene parts, and thus a reliable attribution of the axial configuration of 13 and 14.	isoquinoline	100-112	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	48-51
29608815-7	2018	We reveal that isoquinoline- or naphthyridine-based compounds, such as HSN431, HSN576, HSN459, and HSN608 potently inhibit the enzymatic activities of ABL1, ABL1(T315I), and ABL1(E255K).	isoquinoline	15-27	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	151-155
29949370-7	2018	Both experimental results and DFT computations suggest that the presence of a planar conjugate bipyridyl unit or its isoquinoline derivative is a key feature for stabilizing low valent CoI species toward proton binding.	isoquinoline	117-129	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	185-188
29990896-4	2018	The structure-activity relationship of these compounds was explored to evaluate the effect of the functional group at C-2 in benzazepines and the modification in the aryl group at the isoquinoline C-1 position towards the affinity and selectivity for the mentioned receptors.	isoquinoline	184-196	T cell receptor gamma constant 1	Homo sapiens	197-200
29608815-7	2018	We reveal that isoquinoline- or naphthyridine-based compounds, such as HSN431, HSN576, HSN459, and HSN608 potently inhibit the enzymatic activities of ABL1, ABL1(T315I), and ABL1(E255K).	isoquinoline	15-27	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	157-161
29608815-7	2018	We reveal that isoquinoline- or naphthyridine-based compounds, such as HSN431, HSN576, HSN459, and HSN608 potently inhibit the enzymatic activities of ABL1, ABL1(T315I), and ABL1(E255K).	isoquinoline	15-27	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	157-161
29405651-6	2018	Molecular docking analysis of the isoquinoline 6d reveals its interactions with the LEDGF/p75-binding residues of IN.	isoquinoline	34-46	PC4 and SFRS1 interacting protein 1	Homo sapiens	84-93
29256293-1	2018	The first phase of molecular brain imaging of microglial activation in neuroinflammatory conditions began some 20 years ago with the introduction of [11C]-( R)-PK11195, the prototype isoquinoline ligand for translocator protein (18 kDa) (TSPO).	isoquinoline	183-195	translocator protein	Homo sapiens	207-236
29269216-0	2018	Effects of newly synthetized isoquinoline derivatives on rat uterine contractility and ROCK II activity.	isoquinoline	29-41	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	87-94
29269216-7	2018	We measured the effects of 11 isoquinoline molecules with significant IC50 values on ROCK II activity.	isoquinoline	30-42	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	85-92
27933572-11	2016	There was a statistically significant correlation between OC levels and ISQ values at 1-12 weeks (r = 0.245, P &lt; 0.05).	isoquinoline	72-75	bone gamma-carboxyglutamate protein	Homo sapiens	58-60
28583845-1	2017	To characterize the role of cAMP-dependent protein kinase (PKA) in regulating vascular Ca2+ current through Cav1.2 channels [ICa1.2], we have documented a marked capacity of the isoquinoline H-89, widely used as a PKA inhibitor, to reduce current amplitude.	isoquinoline	178-190	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	43-57
28583845-1	2017	To characterize the role of cAMP-dependent protein kinase (PKA) in regulating vascular Ca2+ current through Cav1.2 channels [ICa1.2], we have documented a marked capacity of the isoquinoline H-89, widely used as a PKA inhibitor, to reduce current amplitude.	isoquinoline	178-190	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	59-62
28583845-1	2017	To characterize the role of cAMP-dependent protein kinase (PKA) in regulating vascular Ca2+ current through Cav1.2 channels [ICa1.2], we have documented a marked capacity of the isoquinoline H-89, widely used as a PKA inhibitor, to reduce current amplitude.	isoquinoline	178-190	islet cell autoantigen 1	Rattus norvegicus	125-129
28583845-1	2017	To characterize the role of cAMP-dependent protein kinase (PKA) in regulating vascular Ca2+ current through Cav1.2 channels [ICa1.2], we have documented a marked capacity of the isoquinoline H-89, widely used as a PKA inhibitor, to reduce current amplitude.	isoquinoline	178-190	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	214-217
28594451-1	2017	An unprecedented two-step spin-crossover behavior with the sequence of gammaHS =1 gammaHS =3/4 gammaHS =1/4 was observed in two-dimensional Hofmann type coordination polymer [Fe(isoq)2 {Ag(CN)2 }2 ] (isoq=isoquinoline), which resulted from three crystallographically inequivalent FeII sites with distinct transition temperatures.	isoquinoline	205-217	spindlin 1	Homo sapiens	26-30
27897286-1	2016	A novel family of square-planar Pd(ii) complexes based on isoquinoline-functionalised pyrazolate ligands [Pd(pzR(n,n)iq)2] (R(n,n) = C6H3(OCnH2n+1)2, n = 4, 6, 8, 10, 12, 14, 16, 18) has been synthesised and characterised.	isoquinoline	58-70	myelin protein zero like 1	Homo sapiens	109-112
29211070-1	2017	We describe a new application of 2-(1-methylhydrazinyl)pyridine as a bidentate directing group to directing cobalt-catalyzed C(sp2)-H alkenylation/annulation of the corresponding benzoic hydrazides to form an isoquinoline backbone, via reacting with a terminal or internal alkyne followed by annulation.	isoquinoline	209-221	Sp2 transcription factor	Homo sapiens	125-130
28688339-0	2017	Brain-derived neurotrophic factor signaling plays a role in resilience to stress promoted by isoquinoline in defeated mice.	isoquinoline	93-105	brain derived neurotrophic factor	Mus musculus	0-33
27981329-2	2017	In contrast, the isoquinoline counterpart 1-isoTQLN exhibits a Cd2+-specific fluorescence increase at 365 nm attributable to monomer emission (ICd/I0 = 83, IZn/ICd = 19%, phiCd = 0.015).	isoquinoline	17-29	CD2 molecule	Homo sapiens	63-66
27981329-2	2017	In contrast, the isoquinoline counterpart 1-isoTQLN exhibits a Cd2+-specific fluorescence increase at 365 nm attributable to monomer emission (ICd/I0 = 83, IZn/ICd = 19%, phiCd = 0.015).	isoquinoline	17-29	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	Homo sapiens	143-146
27981329-2	2017	In contrast, the isoquinoline counterpart 1-isoTQLN exhibits a Cd2+-specific fluorescence increase at 365 nm attributable to monomer emission (ICd/I0 = 83, IZn/ICd = 19%, phiCd = 0.015).	isoquinoline	17-29	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	Homo sapiens	160-163
27052821-4	2016	All tested compounds were selective MAO-B inhibitors, although only the substituted isoquinoline derivative 2b showed IC50 lower than the concentration of 100 muM (IC50 = 82.41 muM).	isoquinoline	84-96	monoamine oxidase B	Homo sapiens	36-41
27624521-1	2016	We report a study of a series of isoquinoline derivatives, including their synthesis, in vitro microsomal leucine aminopeptidase (LAP) inhibition and antiproliferative activity on cancer cell lines.	isoquinoline	33-45	LAP	Homo sapiens	106-128
27624521-1	2016	We report a study of a series of isoquinoline derivatives, including their synthesis, in vitro microsomal leucine aminopeptidase (LAP) inhibition and antiproliferative activity on cancer cell lines.	isoquinoline	33-45	LAP	Homo sapiens	130-133
26811496-4	2016	Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK).	isoquinoline	85-97	autophagy related 7	Homo sapiens	153-177
27326329-2	2016	Optimized compounds in both series exhibited rapid aldehyde oxidase-mediated metabolism, which could be abrogated by introduction of an amino substituent at C5 of the 1,6-naphthyridine scaffold or at C1 of the isoquinoline scaffold.	isoquinoline	210-222	aldehyde oxidase 1	Homo sapiens	51-67
26811496-4	2016	Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK).	isoquinoline	85-97	autophagy related 7	Homo sapiens	179-183
23062825-4	2012	Berberin, palmatine and chelerythrine, chemically clustered in the so-called isoquinoline group, showed promising cholinesterase inhibitory activity and were therefore further investigated.	isoquinoline	77-89	butyrylcholinesterase	Homo sapiens	114-128
24881658-0	2014	Isoquinoline derivatives as potent, selective, and orally active CRTH2 antagonists.	isoquinoline	0-12	prostaglandin D2 receptor 2	Cavia porcellus	65-70
24881658-1	2014	Synthesis and structure-activity relationship of a novel series of isoquinoline CRTH2 antagonists bearing a methylene linker between the isoquinoline and benzamide moieties were described.	isoquinoline	67-79	prostaglandin D2 receptor 2	Cavia porcellus	80-85
24216094-0	2013	Isoquinoline derivatives as potent CRTH2 antagonists: design, synthesis and SAR.	isoquinoline	0-12	prostaglandin D2 receptor 2	Homo sapiens	35-40
24216094-1	2013	In this study, we describe the synthesis and structure-activity relationship (SAR) of a series of isoquinoline chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists.	isoquinoline	98-110	prostaglandin D2 receptor 2	Homo sapiens	180-185
23679855-5	2013	Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439.	isoquinoline	94-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-50
26309138-0	2015	A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes.	isoquinoline	8-20	transferrin	Homo sapiens	96-107
25934226-3	2015	Interestingly, the meta analog of triazole-benzene-sulfonamide (34) bearing 6,7-dimethoxy substituents on the isoquinoline ring displayed the most potent aromatase inhibitory activity (IC50=0.2muM) without affecting normal cell.	isoquinoline	110-122	latexin	Homo sapiens	193-196
25735905-6	2015	VT EPR spectroscopy shows a transient signal corresponding to a triplet state between 20 and 60 K. Complex 2 reacts with PPh3 to generate [Pd(NNO(ISQ))(PPh3)](+) and one equivalent of [PdCl(NNO(ISQ))].	isoquinoline	146-149	protein phosphatase 4 catalytic subunit	Homo sapiens	121-125
25735905-6	2015	VT EPR spectroscopy shows a transient signal corresponding to a triplet state between 20 and 60 K. Complex 2 reacts with PPh3 to generate [Pd(NNO(ISQ))(PPh3)](+) and one equivalent of [PdCl(NNO(ISQ))].	isoquinoline	146-149	protein phosphatase 4 catalytic subunit	Homo sapiens	152-156
24236461-4	2014	Among different phyto-constituents, alkaloids that contain isoquinoline/bis(isoquinoline)and related ring structures (such as berberine, palmatine, coptisine, and jateorrhizine) have shown very potent aldose reductase inhibitory activity.	isoquinoline	59-71	aldo-keto reductase family 1 member B	Homo sapiens	201-217
24236461-7	2014	On the basis of these findings, it may be proposed that the presence of isoquinoline/bis(isoquinoline)ring structures is the most important requirement for alkaloids to behave as potent aldose reductase inhibitors.	isoquinoline	72-84	aldo-keto reductase family 1 member B	Homo sapiens	186-202
24236461-9	2014	The present review discusses these isoquinoline/bis(isoquinoline)-based alkaloids as aldose reductase inhibitors that may be used to manage diabetic complications and may substitute for the chemically synthesized aldose reductase inhibitors.	isoquinoline	35-47	aldo-keto reductase family 1 member B	Homo sapiens	85-101
24236461-9	2014	The present review discusses these isoquinoline/bis(isoquinoline)-based alkaloids as aldose reductase inhibitors that may be used to manage diabetic complications and may substitute for the chemically synthesized aldose reductase inhibitors.	isoquinoline	35-47	aldo-keto reductase family 1 member B	Homo sapiens	213-229
23913808-1	2013	Mix and match: With isoquinoline as the nucleophilic trigger, multicomponent reactions afforded spirooxazino isoquinoline derivatives, proceeding through 1,4-dipolar intermediates.	isoquinoline	20-32	Mix paired-like homeobox	Homo sapiens	0-3
23948248-4	2013	In contrast, substitutions with different electronic properties at either 1"- or 4"-position of the isoquinoline ring of the side chain were generally acceptable for reasonable MOR selectivity.	isoquinoline	100-112	opioid receptor mu 1	Homo sapiens	177-180
23734997-2	2013	The aim of this study is to investigate the antifibrotic activity of isoquinoline alkaloid berberine in carbon tetrachloride (CCl4)-induced damage in mice.	isoquinoline	69-81	chemokine (C-C motif) ligand 4	Mus musculus	126-130
23146122-4	2012	This strategy has also been successfully expanded to the synthesis of MIDA boronate functionalized heterocycles such as isoquinoline, pyrrole, and indole.	isoquinoline	120-132	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	70-74
22153663-2	2012	In our search for new H(4)R ligands, a low affinity isoquinoline fragment was optimized to 7-(furan-2-yl)-4-(piperazin-1-yl)quinazolin-2-amine (VUF11489), as a new H(4)R antagonist.	isoquinoline	52-64	histamine receptor H4	Homo sapiens	22-27
22469703-0	2012	Isoquinoline derivatives as potent CRTH2 receptor antagonists: synthesis and SAR.	isoquinoline	0-12	prostaglandin D2 receptor 2	Homo sapiens	35-40
22469703-0	2012	Isoquinoline derivatives as potent CRTH2 receptor antagonists: synthesis and SAR.	isoquinoline	0-12	sarcosine dehydrogenase	Homo sapiens	77-80
22153663-2	2012	In our search for new H(4)R ligands, a low affinity isoquinoline fragment was optimized to 7-(furan-2-yl)-4-(piperazin-1-yl)quinazolin-2-amine (VUF11489), as a new H(4)R antagonist.	isoquinoline	52-64	histamine receptor H4	Homo sapiens	164-169
22111927-4	2011	A potent and highly selective isoquinoline CHK1 inhibitor (SAR-020106) was identified, which potentiated the efficacies of irinotecan and gemcitabine in SW620 human colon carcinoma xenografts in nude mice.	isoquinoline	30-42	checkpoint kinase 1	Homo sapiens	43-47
21523550-7	2012	The docking analysis also revealed that sulfonylurea derivatives with an isoquinoline or naphthalene scaffold represent potential LAR drugs.	isoquinoline	73-85	protein tyrosine phosphatase receptor type F	Homo sapiens	130-133
20936410-5	2011	RESULTS: The image contrast and the binding of [(11)C]SSR180575 are higher than that obtained with the isoquinoline-based TSPO radioligand, [(11)C]PK11195.	isoquinoline	103-115	translocator protein	Homo sapiens	122-126
21194992-16	2011	The BMP 0.75 and BMP 1.5 groups exhibited significant changes in ISQ compared with the control group: 8.17 +- 8.31 versus 11.50 +- 9.02 versus 2.17 +- 7.61, respectively; P &lt; .05.	isoquinoline	65-68	bone morphogenetic protein 1	Homo sapiens	17-22
21572949-5	2011	This virtual screening has successfully identified an alpha(1A/D)-AR selective antagonist, with low microM affinity with a novel structural scaffold of a an isoquinoline fused three-ring system and good lead-like qualities ideal for further drug development.	isoquinoline	157-169	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	54-62
21858289-1	2011	A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-alpha.	isoquinoline	168-180	tumor necrosis factor	Homo sapiens	215-224
24900292-2	2011	PK 11195, an isoquinoline analogue, is one of the ligands of highest TSPO binding affinity.	isoquinoline	13-25	translocator protein	Homo sapiens	69-73
21215643-0	2011	Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists.	isoquinoline	43-55	cannabinoid receptor 2	Homo sapiens	100-103
21215643-2	2011	Most of the prepared quinoline, isoquinoline, and quinoxalinyl phenyl amines showed low-potency partial CB2 receptor agonists activity.	isoquinoline	32-44	cannabinoid receptor 2	Homo sapiens	104-107
16219465-4	2005	Isoquinoline analogue 33 displayed high affinity and an antagonistic mode of action for the 5-HT(1A) and the 5-HT(1B) receptors and was characterized further with respect to selectivity, electrically stimulated [(3)H]5-HT release and in vivo efficacy.	isoquinoline	0-12	5-hydroxytryptamine receptor 1A	Homo sapiens	92-99
19348415-1	2009	The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described.	isoquinoline	71-83	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	98-117
19348415-1	2009	The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described.	isoquinoline	71-83	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	119-127
17869522-2	2007	An isoquinoline derivative shows good selectivity for the p110alpha isoform over p110beta and p110delta, and also demonstrates good in vitro activity in a cell proliferation assay.	isoquinoline	3-15	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	58-67
17869522-2	2007	An isoquinoline derivative shows good selectivity for the p110alpha isoform over p110beta and p110delta, and also demonstrates good in vitro activity in a cell proliferation assay.	isoquinoline	3-15	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	81-89
17869522-2	2007	An isoquinoline derivative shows good selectivity for the p110alpha isoform over p110beta and p110delta, and also demonstrates good in vitro activity in a cell proliferation assay.	isoquinoline	3-15	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	94-103
16842193-6	2006	Subsequent conformationally restrained isoquinoline and indoleacetamide analogues have been synthesised in an attempt to yield PBR ligands with superior affinity and brain kinetics.	isoquinoline	39-51	translocator protein	Homo sapiens	127-130
20373219-4	2010	The models developed and the participating descriptors advocate that the substituent groups of the isoquinoline moiety hold scope for further modification in the optimization of the caspase-3 inhibitory activity.	isoquinoline	99-111	caspase 3	Homo sapiens	182-191
18672861-6	2008	Most compounds also clearly discriminated between CYP11B2 and CYP11B1, and the CYP1A2 potency significantly decreased in some cases (e.g., isoquinoline derivative 30 displayed only 6% CYP1A2 inhibition at 2 microM concentration).	isoquinoline	139-151	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	79-85
18672861-6	2008	Most compounds also clearly discriminated between CYP11B2 and CYP11B1, and the CYP1A2 potency significantly decreased in some cases (e.g., isoquinoline derivative 30 displayed only 6% CYP1A2 inhibition at 2 microM concentration).	isoquinoline	139-151	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	184-190
17451060-1	2007	The endogenous isoquinoline salsolinol (SALS) is a recently identified prolactin (PRL) releasing factor, a selective and potent stimulator of PRL secretion both in vivo and in vitro.	isoquinoline	15-27	prolactin	Rattus norvegicus	71-80
17451060-1	2007	The endogenous isoquinoline salsolinol (SALS) is a recently identified prolactin (PRL) releasing factor, a selective and potent stimulator of PRL secretion both in vivo and in vitro.	isoquinoline	15-27	prolactin	Rattus norvegicus	82-85
17451060-1	2007	The endogenous isoquinoline salsolinol (SALS) is a recently identified prolactin (PRL) releasing factor, a selective and potent stimulator of PRL secretion both in vivo and in vitro.	isoquinoline	15-27	prolactin	Rattus norvegicus	142-145
16636662-4	2006	All these effects including cell death, loss of mitochondrial Delta Psi m and AIF release were blocked by pretreatment with the poly (ADP-ribose) polymerase inhibitor isoquinoline.	isoquinoline	167-179	apoptosis inducing factor mitochondria associated 1	Homo sapiens	78-81
16373399-3	2006	In this context, we describe the identification and characterization of the isoquinoline derivative PA-082, a prototype of a novel class of non-thiazolidinedione partial PPARgamma ligands.	isoquinoline	76-88	peroxisome proliferator activated receptor gamma	Homo sapiens	170-179
16219465-4	2005	Isoquinoline analogue 33 displayed high affinity and an antagonistic mode of action for the 5-HT(1A) and the 5-HT(1B) receptors and was characterized further with respect to selectivity, electrically stimulated [(3)H]5-HT release and in vivo efficacy.	isoquinoline	0-12	5-hydroxytryptamine receptor 1B	Homo sapiens	109-116
15210579-4	2004	2 Both ATP and the nucleotide analogue 2"-3"-O-(4-benzoylbenzoyl)-ATP (BzATP) induced an 86Rb+ efflux, which was completely inhibited by the isoquinoline derivative 1-(N,O-bis[5-isoquinolinesulphonyl]-N-methyl-l-tyrosyl)-4-phenylpiperazine (KN-62), a potent P2X7 receptor antagonist.	isoquinoline	141-153	purinergic receptor P2X 7	Homo sapiens	258-271
15927466-2	2005	Analogues that incorporated a bulky substituent at the first carbon position of benzylamine or isoquinoline showed over 30-fold selectivity for DPP-IV over both DPP8 and DPP-II.	isoquinoline	95-107	dipeptidyl peptidase 4	Homo sapiens	144-150
15927466-2	2005	Analogues that incorporated a bulky substituent at the first carbon position of benzylamine or isoquinoline showed over 30-fold selectivity for DPP-IV over both DPP8 and DPP-II.	isoquinoline	95-107	dipeptidyl peptidase 8	Homo sapiens	161-165
15927466-2	2005	Analogues that incorporated a bulky substituent at the first carbon position of benzylamine or isoquinoline showed over 30-fold selectivity for DPP-IV over both DPP8 and DPP-II.	isoquinoline	95-107	dipeptidyl peptidase 7	Homo sapiens	170-176
15689158-0	2005	Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.	isoquinoline	154-166	transient receptor potential cation channel subfamily V member 1	Homo sapiens	6-46
15664838-3	2005	To identify potent and selective chemical compounds against DPP8, we have synthesized a series of isoquinoline and isoindoline derivatives and have tested their inhibitory activity against DPP8, DPP-IV and DPP-II.	isoquinoline	98-110	dipeptidyl peptidase 8	Homo sapiens	60-64
15664838-4	2005	Isoindoline derivatives were found to be more potent DPP8 inhibitors than isoquinoline derivatives.	isoquinoline	74-86	dipeptidyl peptidase 8	Homo sapiens	53-57
15664838-6	2005	From SAR results, we speculate that the S1 site of DPP8 may be larger than that of DPP-IV, which would allow the accommodation of larger C-terminal residues, such as isoquinoline or isoindoline.	isoquinoline	166-178	dipeptidyl peptidase 8	Homo sapiens	51-55
15664838-6	2005	From SAR results, we speculate that the S1 site of DPP8 may be larger than that of DPP-IV, which would allow the accommodation of larger C-terminal residues, such as isoquinoline or isoindoline.	isoquinoline	166-178	dipeptidyl peptidase 4	Homo sapiens	83-89
14723961-4	2004	The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives.	isoquinoline	122-134	translocator protein	Rattus norvegicus	72-75
12798691-9	2003	An additional PKA/PKB mutation, Q181K, corrects the defect, as shown both by the crystal structure of triple mutant PKAB3 (PKAalpha V123A, L173M, Q181K) and by surface plasmon resonance spectroscopy binding studies with ATP and three isoquinoline inhibitors.	isoquinoline	234-246	AKT serine/threonine kinase 1	Homo sapiens	18-21
15531802-4	2004	More than 10 microg quantities of each investigated alkaloid or other isoquinoline and aporphine analogs needed for the CI-MS, EI-MS and FAB-MS analysis from the previous studies.	isoquinoline	70-82	FA complementation group B	Homo sapiens	137-140
14649722-2	2003	The inhibitory effect of Ca2+/CaM was attenuated by isoquinoline derivatives (PX 28, 34, 216, 224, and CPU57) and a CaM antagonist W-7.	isoquinoline	52-64	calmodulin	Saccharomyces cerevisiae S288C	30-33
12657723-7	2003	Inhibitors with isoquinoline and quinazoline moieties were recognized by aurora2 in which H-89 and 6,7-dimethoxyquinazoline compounds exhibited high binding energies compared with that of staurosporine.	isoquinoline	16-28	aurora kinase A	Homo sapiens	73-80
11911843-0	2002	Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson"s disease: studies using heterologous expression systems of the dopamine transporter.	isoquinoline	40-52	solute carrier family 6 member 3	Homo sapiens	150-170
12353998-2	2002	Synthetically the methodology provides a simple and convenient route to isoquinolines containing an aryl, alkyl, or vinylic group at C-3 and an aroyl group at C-4 of the isoquinoline ring.	isoquinoline	72-84	complement C3	Homo sapiens	133-136
12353998-2	2002	Synthetically the methodology provides a simple and convenient route to isoquinolines containing an aryl, alkyl, or vinylic group at C-3 and an aroyl group at C-4 of the isoquinoline ring.	isoquinoline	72-84	complement C4A (Rodgers blood group)	Homo sapiens	159-162
12161135-1	2002	Several isoquinoline-based templates were identified from the studies of the conformational effects of the diketopiperazine structures for PAI-1 inhibition.	isoquinoline	8-20	serpin family E member 1	Homo sapiens	139-144
11689087-5	2001	Here we report the discovery of several isoquinoline analogues, exemplified by 1 and 2, which bind IGFBP-3 as well as other IGFBPs at low nanomolar concentrations.	isoquinoline	40-52	insulin like growth factor binding protein 3	Homo sapiens	99-106
11948256-8	2002	Pre-treatment with the isoquinoline PK11195, a specific PBR ligand, attenuated the occurrence of seizures, hyperactivity, and increases in isoquinoline binding protein levels in the hippocampus, which usually follow kainic acid application.	isoquinoline	23-35	translocator protein	Rattus norvegicus	56-59
11948256-8	2002	Pre-treatment with the isoquinoline PK11195, a specific PBR ligand, attenuated the occurrence of seizures, hyperactivity, and increases in isoquinoline binding protein levels in the hippocampus, which usually follow kainic acid application.	isoquinoline	139-151	translocator protein	Rattus norvegicus	56-59
11861809-3	2002	The isoquinoline H89 inhibits PKA and thus should prevent the inactivation of RhoA.	isoquinoline	4-16	ras homolog family member A	Homo sapiens	78-82
12382020-1	2002	The isoquinoline peripheral benzodiazepine receptor ligand PK11195 increased drug (daunomycin)- and fluorochrome (calcein-AM) uptake and induced apoptosis detected by flow cytometry (FCM) technique, DNA electrophoretic analysis and poly(ADP-ribose) polymerase (PARP) cleavage in human multidrug-resistant myeloid leukemia (BL-60/VCR) and ovarian carcinoma (A2780/ADR) cells in vitro.	isoquinoline	4-16	poly(ADP-ribose) polymerase 1	Homo sapiens	232-259
12382020-1	2002	The isoquinoline peripheral benzodiazepine receptor ligand PK11195 increased drug (daunomycin)- and fluorochrome (calcein-AM) uptake and induced apoptosis detected by flow cytometry (FCM) technique, DNA electrophoretic analysis and poly(ADP-ribose) polymerase (PARP) cleavage in human multidrug-resistant myeloid leukemia (BL-60/VCR) and ovarian carcinoma (A2780/ADR) cells in vitro.	isoquinoline	4-16	poly(ADP-ribose) polymerase 1	Homo sapiens	261-265
11689087-5	2001	Here we report the discovery of several isoquinoline analogues, exemplified by 1 and 2, which bind IGFBP-3 as well as other IGFBPs at low nanomolar concentrations.	isoquinoline	40-52	insulin like growth factor binding protein 3	Homo sapiens	124-130
10854431-7	2000	2) The effect was inhibited by oxidized ATP and the isoquinoline KN-62, two known P2X7 receptor antagonists.	isoquinoline	52-64	purinergic receptor P2X 7	Homo sapiens	82-95
11520893-4	2001	The isoquinoline reduced DeltaPsim within 3 h, as detected by a fluorescence indicator, JC-1, then after 16 h incubation, GAPDH accumulated in nuclei by detection with immunostaining.	isoquinoline	4-16	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	122-127
11237767-1	2001	An isoquinoline derivative, 5-methyl-7,8-dimethoxy-1-phenylpyrazolo[5,4-c]isoquinoline (compound 1), was identified as a novel inhibitor of LPS-induced TNF-alpha production by cell-based screening.	isoquinoline	3-15	tumor necrosis factor	Mus musculus	152-161
10841801-0	2000	Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor.	isoquinoline	0-12	adenosine A3 receptor	Homo sapiens	73-96
10841801-3	2000	A structure-affinity analysis indicated that on the 2-position of the quinazoline ring or the equivalent 3-position of the isoquinoline ring a phenyl or heteroaryl substituent increased the adenosine A(3) receptor affinity in comparison to unsubstituted or aliphatic derivatives.	isoquinoline	123-135	adenosine A3 receptor	Homo sapiens	190-213
10813936-4	2000	The connecting isoquinoline and the steric interaction between the aromatic moiety and the Me-1 substituent can block the oxazaphosphorinane ring.	isoquinoline	15-27	malic enzyme 1	Homo sapiens	91-95
11128601-5	2000	The isoquinoline activated caspase-3 like proteases and a caspase-3 inhibitor protected the cells from DNA damage.	isoquinoline	4-16	caspase 3	Homo sapiens	27-36
10364850-2	1999	The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay in human hepatoma cells.	isoquinoline	75-87	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	169-173
9767636-6	1998	A structure-activity relationship analysis indicated that a phenyl group when coupled by a spacer allowing conjugation on position 1 of the isoquinoline ring increased the adenosine A3 receptor affinity.	isoquinoline	140-152	adenosine A3 receptor	Homo sapiens	172-193
10353597-6	1999	Accordingly, the cell death-inducing effect of LND is amplified by simultaneous addition of PK11195, an isoquinoline ligand of the peripheral benzodiazepine receptor which antagonizes the cytoprotective effect of Bcl-2.	isoquinoline	104-116	BCL2 apoptosis regulator	Homo sapiens	213-218
9918542-3	1999	In attempting to characterize the role of protein kinase A (PKA) in regulating the beta-2 adrenergic receptor (AR) in human airway cells, we observed a seemingly profound capacity of the isoquinoline H-89, a potent and widely used PKA inhibitor, to attenuate agonist-mediated desensitization of the beta-2 AR.	isoquinoline	187-199	adrenoceptor beta 2	Homo sapiens	83-109
9918542-3	1999	In attempting to characterize the role of protein kinase A (PKA) in regulating the beta-2 adrenergic receptor (AR) in human airway cells, we observed a seemingly profound capacity of the isoquinoline H-89, a potent and widely used PKA inhibitor, to attenuate agonist-mediated desensitization of the beta-2 AR.	isoquinoline	187-199	adrenoceptor beta 2	Homo sapiens	299-308
9767637-5	1998	First, the influence of an amide group at position 1 of the isoquinoline ring on the adenosine A3 receptor affinity was determined.	isoquinoline	60-72	adenosine A3 receptor	Homo sapiens	85-106
9401954-0	1997	Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products.	isoquinoline	0-12	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	81-96
9711973-5	1998	Based on converging evidence, the view is advanced that endogenous, genetically based (excessive) formation, or accumulation, of toxic DA transporter substrates, such as isoquinoline or beta-carboline derivatives, may in fact represent the primary cause of substantia nigra cell degeneration in patients with PD.	isoquinoline	170-182	solute carrier family 6 member 3	Homo sapiens	135-149
9527511-10	1997	These studies demonstrate that the isoquinoline and benzodiazepine sites on the peripheral-type benzodiazepine receptor in human brain manifest many pharmacological characteristics that are distinct from each other and from rodent brain peripheral-type benzodiazepine receptors.	isoquinoline	35-47	translocator protein	Homo sapiens	80-119
9113369-0	1997	The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.	isoquinoline	4-16	purinergic receptor P2X 7	Homo sapiens	61-73
9101367-5	1997	Two inhibitors of PKA, the isoquinoline-sulfonamide derivative, H-89 and a cAMP analog, RpcAMP, blocked the ability of PGE1 to down-regulate collagenase-1 gene expression.	isoquinoline	27-39	interstitial collagenase	Oryctolagus cuniculus	141-154