PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11992633-0	2002	7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	0-59	regulating synaptic membrane exocytosis 2	Homo sapiens	126-141
11992633-2	2002	Treatment of LXFL529L cells with the potent PDE4 inhibitor 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine (DC-TA-46) induces dose-dependent growth inhibition.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	59-118	phosphodiesterase 4A	Homo sapiens	44-48
11992633-2	2002	Treatment of LXFL529L cells with the potent PDE4 inhibitor 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine (DC-TA-46) induces dose-dependent growth inhibition.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	120-128	phosphodiesterase 4A	Homo sapiens	44-48
11992633-5	2002	DC-TA-46 mediated inhibition of PDE4 activity in LXFL529L cells resulted in an increase of the intracellular cAMP level and significant induction of the activity of protein kinase A (PKA).	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	0-8	phosphodiesterase 4A	Homo sapiens	32-36
11992634-1	2002	7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine (DC-TA-46) is a potent inhibitor of the rolipram-sensitive cAMP-specific phosphodiesterase isoenzyme family PDE4.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	0-59	phosphodiesterase 4A	Homo sapiens	168-172
11992634-1	2002	7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine (DC-TA-46) is a potent inhibitor of the rolipram-sensitive cAMP-specific phosphodiesterase isoenzyme family PDE4.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	61-69	phosphodiesterase 4A	Homo sapiens	168-172
11992634-2	2002	DC-TA-46 inhibits cAMP-hydrolysis of PDE4 isolated from solid tumors of the human large cell lung tumor xenograft LXFL529 in the nanomolar range (IC(50)=16+/-5nM).	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	0-8	phosphodiesterase 4A	Homo sapiens	37-41
9515161-8	1998	Treatment of CarB cells with DC-TA-46 strongly inhibits intracellular PDE activity, resulting in a marked and long-lasting rise of cAMP.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	29-37	syntaxin 8	Mus musculus	13-17
9822544-2	1998	7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine (7a) is a potent inhibitor of the cAMP-specific phosphodiesterase isoenzyme family PDE4 and induces growth inhibition in a panel of tumor cell lines.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	0-58	phosphodiesterase 4A	Homo sapiens	142-146
9822544-2	1998	7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine (7a) is a potent inhibitor of the cAMP-specific phosphodiesterase isoenzyme family PDE4 and induces growth inhibition in a panel of tumor cell lines.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	60-62	phosphodiesterase 4A	Homo sapiens	142-146
27859531-7	2017	Rolipram (10 muM) and DC-TA-46 (0.5 muM) produced a decrease of cyclin expression, in particular of cyclin A, as well as an increase in p21, p27 and p53, as evaluated by Western blot analysis.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	22-30	latexin	Homo sapiens	36-39
27859531-7	2017	Rolipram (10 muM) and DC-TA-46 (0.5 muM) produced a decrease of cyclin expression, in particular of cyclin A, as well as an increase in p21, p27 and p53, as evaluated by Western blot analysis.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	22-30	proliferating cell nuclear antigen	Homo sapiens	64-70
27859531-7	2017	Rolipram (10 muM) and DC-TA-46 (0.5 muM) produced a decrease of cyclin expression, in particular of cyclin A, as well as an increase in p21, p27 and p53, as evaluated by Western blot analysis.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	22-30	cyclin A2	Homo sapiens	100-108
27859531-7	2017	Rolipram (10 muM) and DC-TA-46 (0.5 muM) produced a decrease of cyclin expression, in particular of cyclin A, as well as an increase in p21, p27 and p53, as evaluated by Western blot analysis.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	22-30	H3 histone pseudogene 16	Homo sapiens	136-139
27859531-7	2017	Rolipram (10 muM) and DC-TA-46 (0.5 muM) produced a decrease of cyclin expression, in particular of cyclin A, as well as an increase in p21, p27 and p53, as evaluated by Western blot analysis.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	22-30	interferon alpha inducible protein 27	Homo sapiens	141-144
27859531-7	2017	Rolipram (10 muM) and DC-TA-46 (0.5 muM) produced a decrease of cyclin expression, in particular of cyclin A, as well as an increase in p21, p27 and p53, as evaluated by Western blot analysis.	7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	22-30	tumor protein p53	Homo sapiens	149-152