PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25462239-0	2015	Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study.	malonic acid	0-8	serine racemase	Homo sapiens	39-54
25462239-4	2015	Here we present the synthesis and activity analysis of a series of malonate-based inhibitors of mouse serine racemase (mSR).	malonic acid	67-75	serine racemase	Mus musculus	102-117
25462239-4	2015	Here we present the synthesis and activity analysis of a series of malonate-based inhibitors of mouse serine racemase (mSR).	malonic acid	67-75	macrophage scavenger receptor 1	Mus musculus	119-122
25462239-6	2015	The structure-activity relationship of the whole series in the human orthologue (hSR) was interpreted using Glide docking, WaterMap analysis of hydration and quantum mechanical calculations based on the X-ray structure of the hSR/malonate complex.	malonic acid	230-238	HSR	Homo sapiens	81-84
24794562-9	2014	The MifR protein is homologous to other transcriptional regulators involved in dicarboxylate assimilation, suggesting that MifR might interact with RpoN to activate the expression of the PA5530 gene in response to extracellular C5-dicarboxylates, especially alpha-KG.	malonic acid	79-92	DNA-binding response regulator MifR	Pseudomonas aeruginosa PAO1	4-8
25331425-0	2015	Regulation of human serine racemase activity and dynamics by halides, ATP and malonate.	malonic acid	78-86	serine racemase	Homo sapiens	20-35
25331425-6	2015	ATP increased ninefold the affinity of hSR for malonate and malonate increased 100-fold that of ATP, confirming an allosteric interaction between the two binding sites.	malonic acid	47-55	HSR	Homo sapiens	39-42
25331425-6	2015	ATP increased ninefold the affinity of hSR for malonate and malonate increased 100-fold that of ATP, confirming an allosteric interaction between the two binding sites.	malonic acid	60-68	HSR	Homo sapiens	39-42
25066953-4	2014	The newly developed inhibitors have lower IC50 value comparing with that of malonate, one of the standard SR inhibitor.	malonic acid	76-84	serine racemase	Homo sapiens	106-108
24794562-9	2014	The MifR protein is homologous to other transcriptional regulators involved in dicarboxylate assimilation, suggesting that MifR might interact with RpoN to activate the expression of the PA5530 gene in response to extracellular C5-dicarboxylates, especially alpha-KG.	malonic acid	79-92	DNA-binding response regulator MifR	Pseudomonas aeruginosa PAO1	123-127
24794562-9	2014	The MifR protein is homologous to other transcriptional regulators involved in dicarboxylate assimilation, suggesting that MifR might interact with RpoN to activate the expression of the PA5530 gene in response to extracellular C5-dicarboxylates, especially alpha-KG.	malonic acid	79-92	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	148-152
24794562-9	2014	The MifR protein is homologous to other transcriptional regulators involved in dicarboxylate assimilation, suggesting that MifR might interact with RpoN to activate the expression of the PA5530 gene in response to extracellular C5-dicarboxylates, especially alpha-KG.	malonic acid	79-92	MFS dicarboxylate transporter	Pseudomonas aeruginosa PAO1	187-193
24586272-7	2014	Malonate promoted a NAD(+) decrease that was not prevented by 3-aminobenzamide, a poly(ADP-ribose)polymerase inhibitor, at 4 and 24 hours.	malonic acid	0-8	poly (ADP-ribose) polymerase 1	Rattus norvegicus	82-108
24136226-1	2013	The cannabinoid CB2 receptor, which is activated by the endocannabinoid 2-arachidonoyl-glycerol (2-AG), protects striatal neurons from apoptotic death caused by the local administration of malonate, a rat model of Huntington"s disease (HD).	malonic acid	189-197	cannabinoid receptor 2	Rattus norvegicus	16-28
24479838-1	2014	The alkylation of (Z)-3-aryl-2-fluoroallyl acetate with the malonate anion by the [Pd(C3H5)(cod)]BF4/2,2"-bpy catalyst proceeds through the carbon-fluorine bond cleavage, and 2 equiv of the malonate nucleophile was introduced to the allyl substrate.	malonic acid	60-68	forkhead box G1	Homo sapiens	97-102
24292006-1	2014	The aqueous biphasic system (ABS) involving sodium malonate-polyethylene glycol (PEG) phases has been applied for the first time for separation of no-carrier-added (183)Re (T1/2=70 d) from alpha-particle irradiated bulk tantalum target.	malonic acid	44-59	interleukin 1 receptor like 1	Homo sapiens	173-182
24053613-6	2014	Inhibition of mitochondrial reverse electron transfer with malonate, malate, or rotenone attenuated AngII-induced cytoplasmic and mitochondrial O2( -) production.	malonic acid	59-67	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	100-105
24729915-1	2014	The research was performed to study the simultaneous detection of a homologous series of alpha , omega -dicarboxylic acids (C2-C10), oxalic, malonic, succinic, glutaric, adipic, pimelic, suberic, azelaic, and sebacic acids, with capillary electrophoresis using indirect UV detection.	malonic acid	89-122	homeobox C10	Homo sapiens	127-130
25206650-3	2013	In the later stages of the malonate insult, TDP-43 expression reduced in the nuclei and transferred to the cytoplasm.	malonic acid	27-35	TAR DNA binding protein	Mus musculus	44-50
25206650-5	2013	Interestingly, in the early stages of the response to malonate treatment, nuclear TDP-43 expression increased, and neurons remained relatively intact, without inclusion bodies or fragmentation.	malonic acid	54-62	TAR DNA binding protein	Mus musculus	82-88
25206650-7	2013	This hypothesis was confirmed by an in vitro transgenic experiment, in which overexpression of wild type mouse TDP-43 in cultured cortical motor neurons significantly reduced malonate-induced neuronal death.	malonic acid	175-183	TAR DNA binding protein	Mus musculus	111-117
24136226-10	2013	In M-213 cells exposed to malonate, in which COX-2 was also upregulated, JZL184 worsened neurotoxicity, and this effect was attenuated by the COX-2 inhibitor celecoxib or AGN220675.	malonic acid	26-34	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	45-50
24136226-10	2013	In M-213 cells exposed to malonate, in which COX-2 was also upregulated, JZL184 worsened neurotoxicity, and this effect was attenuated by the COX-2 inhibitor celecoxib or AGN220675.	malonic acid	26-34	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	142-147
24136226-12	2013	In conclusion, the inhibition of 2-AG biosynthesis is neuroprotective in rats lesioned with malonate, possibly through the counteraction of the formation of pro-neuroinflammatory PGE2-G, formed from COX-2-mediated oxygenation of 2-AG.	malonic acid	92-100	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	199-204
24136226-13	2013	Accordingly, MAGL inhibition or the administration of PGE2-G aggravates the malonate toxicity.	malonic acid	76-84	monoglyceride lipase	Rattus norvegicus	13-17
23813405-7	2013	A dicarboxylic acid plasma membrane transporter with the ability to uptake exogenous malonic acid was identified from another species of yeast known as Schizosaccharomyces pombe and the gene encoding this transporter is identified as the mae1 gene.	malonic acid	85-97	malate dehydrogenase (oxaloacetate-decarboxylating)	Saccharomyces cerevisiae S288C	238-242
23928095-2	2013	The crystal structures of mouse P5CDH complexed with glutarate, succinate, malonate, glyoxylate, and acetate are reported.	malonic acid	75-83	aldehyde dehydrogenase 4 family, member A1	Mus musculus	32-37
23928095-6	2013	Inhibition of P5CDH by glyoxylate, malonate, succinate, glutarate, and l-glutamate is also examined.	malonic acid	35-43	aldehyde dehydrogenase 4 family, member A1	Mus musculus	14-19
23828654-6	2013	Interestingly, the excised KirCI-AT2 can also transfer malonate to ACP5 and thus has a relaxed ACP-specificity compared to the entire KirCI protein.	malonic acid	55-63	acid phosphatase 5, tartrate resistant	Homo sapiens	67-71
23807634-5	2013	Here, we report three crystal structures of human ACP6 in complex with malonate, L-(+)-tartrate and tris, respectively.	malonic acid	71-79	acid phosphatase 6, lysophosphatidic	Homo sapiens	50-54
23642436-5	2013	METHODS: SDH activity was measured in isolated mitochondria exposed to succinate (control), malonate (inhibitor of succinate dehydrogenase), diazoxide, and varying concentrations of glutathione alone or in combination with diazoxide.	malonic acid	92-100	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	9-12
23659346-5	2013	Short- and long-term troglitazone administration in Sod2(+/-) mouse led to a mitochondrial proteome shift from an early compensatory response to an eventual phase of intolerable oxidative stress, due to decreased mitochondrial glutathione (mGSH) import protein, decreased dicarboxylate ion carrier (DIC), and the specific activation of ASK1-JNK and FOXO3a with prolonged troglitazone exposure.	malonic acid	272-285	superoxide dismutase 2, mitochondrial	Mus musculus	52-56
23642436-9	2013	RESULTS: Both malonate and diazoxide inhibited succinate dehydrogenase.	malonic acid	14-22	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	47-70
24247155-3	2013	Due to the dicarboxylate-like structure, we postulated that GSH uptake across the basolateral membrane is mediated by the sodium-dependent dicarboxylate transporter 3 (NaDC3).	malonic acid	11-24	solute carrier family 13 member 5	Homo sapiens	122-164
23535164-9	2013	RESULTS: Both malonate and diazoxide inhibit SDH activity in mitochondria of wild-type mice and in mice lacking the SUR1 subunit (p < 0.05 vs control).	malonic acid	14-22	aminoadipate-semialdehyde synthase	Mus musculus	45-48
23535164-9	2013	RESULTS: Both malonate and diazoxide inhibit SDH activity in mitochondria of wild-type mice and in mice lacking the SUR1 subunit (p < 0.05 vs control).	malonic acid	14-22	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	116-120
23186227-10	2013	Thus, malonate induced the activation of apoptosis signal-regulating kinase-1 (ASK1) and two MAPK kinases, MKK3/6 and MKK7, which lead to an increased phosphorylation of JNK and p38 MAPK, effects that were blocked by sildenafil.	malonic acid	6-14	mitogen-activated protein kinase 8	Rattus norvegicus	170-173
23186227-10	2013	Thus, malonate induced the activation of apoptosis signal-regulating kinase-1 (ASK1) and two MAPK kinases, MKK3/6 and MKK7, which lead to an increased phosphorylation of JNK and p38 MAPK, effects that were blocked by sildenafil.	malonic acid	6-14	mitogen activated protein kinase 14	Rattus norvegicus	178-181
23186227-12	2013	While inhibition of p38 provided a significant protection against malonate-induced neurotoxicity, inhibition of JNK did not.	malonic acid	66-74	mitogen activated protein kinase 14	Rattus norvegicus	20-23
23186227-13	2013	CONCLUSIONS AND IMPLICATIONS: Sildenafil protects against the chemical hypoxia induced by malonate through the regulation of the ASK1-MKK3/6-p38/MAPK signalling pathway.	malonic acid	90-98	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	129-133
23186227-13	2013	CONCLUSIONS AND IMPLICATIONS: Sildenafil protects against the chemical hypoxia induced by malonate through the regulation of the ASK1-MKK3/6-p38/MAPK signalling pathway.	malonic acid	90-98	mitogen activated protein kinase kinase 3	Rattus norvegicus	134-138
23186227-13	2013	CONCLUSIONS AND IMPLICATIONS: Sildenafil protects against the chemical hypoxia induced by malonate through the regulation of the ASK1-MKK3/6-p38/MAPK signalling pathway.	malonic acid	90-98	mitogen activated protein kinase 14	Rattus norvegicus	141-144
23036115-8	2013	Application of the SDH inhibitor, malonate, phenocopied the sdhaf2 root architecture in WT.	malonic acid	34-42	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	19-22
23036115-8	2013	Application of the SDH inhibitor, malonate, phenocopied the sdhaf2 root architecture in WT.	malonic acid	34-42	succinate dehydrogenase assembly factor	Arabidopsis thaliana	60-66
23637528-2	2013	In this study we exploited modified fullerene (diadduct malonic acid-fullerene-Asn-Gly-Arg peptide [DMA-C60-NGR]) as an antitumor drug carrier in order to build a new tumor-targeting drug delivery system.	malonic acid	56-68	reticulon 4 receptor	Homo sapiens	108-111
23415811-0	2013	Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.	malonic acid	132-140	cyclin-dependent kinase 5	Rattus norvegicus	36-40
23415811-6	2013	Thus, malonate induced the activation of the calcium-dependent protease, calpain and the cyclin-dependent kinase 5, cdk5; which resulted in the hyperphosphorylation of tau and the cleavage of the protective transcription factor, myocyte enhancer factor 2, MEF2.	malonic acid	6-14	cyclin-dependent kinase 5	Rattus norvegicus	89-114
23415811-6	2013	Thus, malonate induced the activation of the calcium-dependent protease, calpain and the cyclin-dependent kinase 5, cdk5; which resulted in the hyperphosphorylation of tau and the cleavage of the protective transcription factor, myocyte enhancer factor 2, MEF2.	malonic acid	6-14	cyclin-dependent kinase 5	Rattus norvegicus	116-120
23415811-7	2013	All these effects were also significantly reduced by sildenafil pre-treatment, suggesting that sildenafil protects against malonate-induced cell death through the regulation of the calpain/p25/cdk5 signaling pathway.	malonic acid	123-131	lipocalin 2	Rattus norvegicus	189-192
23415811-7	2013	All these effects were also significantly reduced by sildenafil pre-treatment, suggesting that sildenafil protects against malonate-induced cell death through the regulation of the calpain/p25/cdk5 signaling pathway.	malonic acid	123-131	cyclin-dependent kinase 5	Rattus norvegicus	193-197
23186227-0	2013	Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate.	malonic acid	124-132	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	18-22
23186227-0	2013	Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate.	malonic acid	124-132	mitogen activated protein kinase kinase 3	Rattus norvegicus	23-27
23186227-0	2013	Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate.	malonic acid	124-132	mitogen activated protein kinase 14	Rattus norvegicus	30-33
23186227-10	2013	Thus, malonate induced the activation of apoptosis signal-regulating kinase-1 (ASK1) and two MAPK kinases, MKK3/6 and MKK7, which lead to an increased phosphorylation of JNK and p38 MAPK, effects that were blocked by sildenafil.	malonic acid	6-14	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	41-77
23186227-10	2013	Thus, malonate induced the activation of apoptosis signal-regulating kinase-1 (ASK1) and two MAPK kinases, MKK3/6 and MKK7, which lead to an increased phosphorylation of JNK and p38 MAPK, effects that were blocked by sildenafil.	malonic acid	6-14	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	79-83
23186227-10	2013	Thus, malonate induced the activation of apoptosis signal-regulating kinase-1 (ASK1) and two MAPK kinases, MKK3/6 and MKK7, which lead to an increased phosphorylation of JNK and p38 MAPK, effects that were blocked by sildenafil.	malonic acid	6-14	mitogen activated protein kinase kinase 3	Rattus norvegicus	107-111
23186227-10	2013	Thus, malonate induced the activation of apoptosis signal-regulating kinase-1 (ASK1) and two MAPK kinases, MKK3/6 and MKK7, which lead to an increased phosphorylation of JNK and p38 MAPK, effects that were blocked by sildenafil.	malonic acid	6-14	mitogen activated protein kinase kinase 7	Rattus norvegicus	118-122
24247155-3	2013	Due to the dicarboxylate-like structure, we postulated that GSH uptake across the basolateral membrane is mediated by the sodium-dependent dicarboxylate transporter 3 (NaDC3).	malonic acid	11-24	solute carrier family 13 member 3	Homo sapiens	168-173
21865262-10	2011	OAT3 showed the same dicarboxylate selectivity with ~13-fold higher IC(50) values compared with OAT1.	malonic acid	21-34	solute carrier family 22 member 8	Homo sapiens	0-4
22858636-1	2012	The Medicago truncatula NIP/LATD (for Numerous Infections and Polyphenolics/Lateral root-organ Defective) gene encodes a protein found in a clade of nitrate transporters within the large NRT1(PTR) family that also encodes transporters of dipeptides and tripeptides, dicarboxylates, auxin, and abscisic acid.	malonic acid	266-280	nitrate transporter 1.1	Arabidopsis thaliana	187-191
21865262-1	2011	Organic anions are taken up from the blood into proximal tubule cells by organic anion transporters 1 and 3 (OAT1 and OAT3) in exchange for dicarboxylates.	malonic acid	140-154	solute carrier family 22 member 6	Homo sapiens	109-113
21865262-1	2011	Organic anions are taken up from the blood into proximal tubule cells by organic anion transporters 1 and 3 (OAT1 and OAT3) in exchange for dicarboxylates.	malonic acid	140-154	solute carrier family 22 member 8	Homo sapiens	118-122
21865262-3	2011	In this study, we tested the substrate specificities of human NaDC3, OAT1, and OAT3 to identify those dicarboxylates for which the three cooperating transporters have common high affinities.	malonic acid	102-116	solute carrier family 13 member 3	Homo sapiens	62-67
22511576-2	2012	The reactive nucleophile is generated in situ from the respective malonate using CBr(4)  and a base.	malonic acid	66-74	carbonyl reductase 4	Homo sapiens	81-87
22505679-1	2012	Bacteria catabolize malonate via two pathways, encoded by the mdc and mat genes.	malonic acid	20-28	C-C motif chemokine ligand 22	Homo sapiens	62-65
22645761-0	2012	[Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors].	malonic acid	37-49	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	56-61
22645761-3	2012	Malonic acid moiety was used herein as a mimic of the phosphate group in pTyr, and novel malonic acid derivatives 1-7 were designed, synthesized and evaluated as PTP1B inhibitors.	malonic acid	89-101	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	162-167
21865262-3	2011	In this study, we tested the substrate specificities of human NaDC3, OAT1, and OAT3 to identify those dicarboxylates for which the three cooperating transporters have common high affinities.	malonic acid	102-116	solute carrier family 22 member 6	Homo sapiens	69-73
21865262-3	2011	In this study, we tested the substrate specificities of human NaDC3, OAT1, and OAT3 to identify those dicarboxylates for which the three cooperating transporters have common high affinities.	malonic acid	102-116	solute carrier family 22 member 8	Homo sapiens	79-83
21865262-11	2011	The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 and 2) suggest potentially similar molecular structures of the binding sites in OAT1 and OAT3 for dicarboxylates.	malonic acid	198-212	solute carrier family 13 member 3	Homo sapiens	78-83
21865262-4	2011	All transporters were stably expressed in HEK293 cells, and extracellularly added dicarboxylates were used as inhibitors of [(14)C]succinate (NaDC3), p-[(3)H]aminohippurate (OAT1), or [(3)H]estrone-3-sulfate (OAT3) uptake.	malonic acid	82-96	solute carrier family 13 member 3	Homo sapiens	142-147
21865262-4	2011	All transporters were stably expressed in HEK293 cells, and extracellularly added dicarboxylates were used as inhibitors of [(14)C]succinate (NaDC3), p-[(3)H]aminohippurate (OAT1), or [(3)H]estrone-3-sulfate (OAT3) uptake.	malonic acid	82-96	solute carrier family 22 member 6	Homo sapiens	174-178
21865262-4	2011	All transporters were stably expressed in HEK293 cells, and extracellularly added dicarboxylates were used as inhibitors of [(14)C]succinate (NaDC3), p-[(3)H]aminohippurate (OAT1), or [(3)H]estrone-3-sulfate (OAT3) uptake.	malonic acid	82-96	solute carrier family 22 member 8	Homo sapiens	209-213
21865262-11	2011	The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 and 2) suggest potentially similar molecular structures of the binding sites in OAT1 and OAT3 for dicarboxylates.	malonic acid	198-212	solute carrier family 22 member 8	Homo sapiens	95-105
21865262-11	2011	The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 and 2) suggest potentially similar molecular structures of the binding sites in OAT1 and OAT3 for dicarboxylates.	malonic acid	198-212	solute carrier family 22 member 6	Homo sapiens	180-184
21865262-11	2011	The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 and 2) suggest potentially similar molecular structures of the binding sites in OAT1 and OAT3 for dicarboxylates.	malonic acid	198-212	solute carrier family 22 member 8	Homo sapiens	95-99
21642549-6	2011	Recombinant AAE13 protein showed high activity against malonic acid (K(m) = 529.4 +- 98.5 muM; V(m) = 24.0 +- 2.7 mumol/mg/min) but little or no activity against other dicarboxylic or fatty acids tested.	malonic acid	55-67	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	12-17
21674569-7	2011	Finally, this combination also reversed the up-regulation of proinflammatory markers such as inducible nitric oxide synthase observed in malonate-lesioned rats.	malonic acid	137-145	nitric oxide synthase 2	Rattus norvegicus	93-124
21371748-4	2011	Here, we show that a bis-adduct malonic acid derivative of fullerene, C60(C(COOH)2)2, inhibits tumor necrosis factor alpha-initiated cellular apoptosis via stabilizing lysosomes.	malonic acid	32-44	tumor necrosis factor	Homo sapiens	95-122
21887436-0	2011	Co(II), Mn(II) and Cu(II)-directed coordination polymers with mixed tetrazolate-dicarboxylate heterobridges exhibiting spin-canted, spin-frustrated antiferromagnetism and a slight spin-flop transition.	malonic acid	80-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
21846720-4	2011	The human candidate protein ACSF3, which has a predicted N-terminal mitochondrial targeting sequence, was cloned, expressed, and characterized as a 65-kDa acyl-CoA synthetase with extremely high specificity for malonate and methylmalonate.	malonic acid	211-219	acyl-CoA synthetase family member 3	Homo sapiens	28-33
21846720-5	2011	An arginine residue implicated in malonate binding by prokaryotic malonyl-CoA synthetases was found to be positionally conserved in animal ACSF3 enzymes and essential for activity.	malonic acid	34-42	acyl-CoA synthetase family member 3	Homo sapiens	139-144
21846720-7	2011	In conclusion, unlike fungi, which have an intramitochondrial acetyl-CoA carboxylase, animals require an alternative source of mitochondrial malonyl-CoA; the mitochondrial ACSF3 enzyme is capable of filling this role by utilizing free malonic acid as substrate.	malonic acid	235-247	acyl-CoA synthetase family member 3	Homo sapiens	172-177
21643438-3	2011	Mouse L-PGDS with a C65A mutation was previously crystallized with citrate or malonate as a precipitant, and the X-ray crystallographic structure was determined at 2.0 A resolution.	malonic acid	78-86	prostaglandin D2 synthase (brain)	Mus musculus	6-12
21491491-3	2011	The precipitant, malonate, employed for the crystallization is itself a weak inhibitor of phosphoenolpyruvate carboxylase and a malonate molecule is seen in the active-site in the crystal structure.	malonic acid	17-25	MLO-like protein 4	Zea mays	90-121
21642549-10	2011	Our results demonstrate that the malonyl-CoA synthetase encoded by AAE13 is essential for healthy growth and development, probably because it is required for the detoxification of malonate.	malonic acid	180-188	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	67-72
21123491-2	2011	The major transporter to reabsorb citrate is Na(+)-dicarboxylate cotransporter (NaDC1), which transports dicarboxylates, including the divalent form of citrate.	malonic acid	105-119	solute carrier family 13 member 2	Oryctolagus cuniculus	80-85
21754320-3	2011	The Co(II) atom is in an almost octa-hedral environment formed by four carboxyl-ate O atoms from two malonate ligands and two water O atoms.	malonic acid	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20211941-4	2010	In previous work, our laboratory found that Nrf2 protects from intrastriatal injections of the mitochondrial complex II inhibitor malonate.	malonic acid	130-138	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
20538765-1	2010	Glutathione transport into mitochondria is mediated by oxoglutarate (OGC) and dicarboxylate carrier (DIC) in the kidney and liver.	malonic acid	78-91	solute carrier family 25 member 10	Rattus norvegicus	101-104
20211941-6	2010	GFAP-Nrf2 transgenic mice are significantly more resistant to malonate lesioning.	malonic acid	62-70	glial fibrillary acidic protein	Mus musculus	0-4
20211941-6	2010	GFAP-Nrf2 transgenic mice are significantly more resistant to malonate lesioning.	malonic acid	62-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	5-9
20211941-8	2010	Furthermore, striatal transplantation of neuroprogenitor cells overexpressing Nrf2 that differentiate into astrocytes after grafting also significantly reduced malonate toxicity.	malonic acid	160-168	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
20188726-5	2010	Ipsilateral striatal malonic acid (3 and 6 micromol) administration significantly reduced body weight, locomotor activity, motor coordination and caused oxidative damage (lipid peroxidation, nitrite, superoxide dismutase, catalase and glutathione) in the striatum as compared to sham treated animal.	malonic acid	21-33	catalase	Rattus norvegicus	222-230
20380411-1	2010	The DNA binding property of a Cu(II) complex, viz., [Cu(mal)(2)](picH)(2).2H(2)O, (mal)(2) = malonic acid, picH = protonated 2-amino-4-picoline, has been investigated in this study.	malonic acid	93-105	ERCC excision repair 6 like, spindle assembly checkpoint helicase	Homo sapiens	65-69
20171189-12	2010	The Oac1p, dicarboxylate (Dic1p) and PTP transporter subunits form heterodimers with even lower affinities.	malonic acid	11-24	dynein axonemal intermediate chain 1	Homo sapiens	26-31
20380447-8	2010	All of the flexible dicarboxylate ligands adopt a syn conformation except that in complex 2, indicating that the syn conformational ligand is helpful for the formation of a metallamacrocycle and a MOCC.	malonic acid	20-33	synemin	Homo sapiens	50-53
20380447-8	2010	All of the flexible dicarboxylate ligands adopt a syn conformation except that in complex 2, indicating that the syn conformational ligand is helpful for the formation of a metallamacrocycle and a MOCC.	malonic acid	20-33	synemin	Homo sapiens	113-116
20171189-12	2010	The Oac1p, dicarboxylate (Dic1p) and PTP transporter subunits form heterodimers with even lower affinities.	malonic acid	11-24	solute carrier family 25 member 3	Homo sapiens	37-40
19653678-2	2009	Malonyl-CoA synthetase (MCS) was used in conjunction with chalcone synthase (CHS), thereby allowing efficient use of synthetic starter molecules and malonate as extender.	malonic acid	149-157	acyl-CoA synthetase family member 3	Homo sapiens	0-22
19885534-1	2009	Two isomorphous 3D Mn(II) and Co(II) coordination polymers with a dicarboxylate inner salt and cyanate as coligands were synthesized and structurally characterized, and their magnetic properties have been studied.	malonic acid	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
19536567-2	2009	The structural characterizations of these species by 1H NMR and IR spectroscopies suggest that both molybdenocene complexes contain the ligands in a bidentate fashion and elemental analysis and mass spectrometry corroborate the proposed formula for the species to be Cp2Mo(malonate) and [Cp2Mo(maltolato)]Cl (Cp is cyclopentadienyl).	malonic acid	273-281	ceruloplasmin	Homo sapiens	267-270
19525321-0	2009	CYP86B1 is required for very long chain omega-hydroxyacid and alpha, omega -dicarboxylic acid synthesis in root and seed suberin polyester.	malonic acid	62-93	cytochrome P450, family 86, subfamily B, polypeptide 1	Arabidopsis thaliana	0-7
19115380-3	2009	Our results showed that only compounds able to activate CB2 receptors were capable of protecting striatal projection neurons from malonate-induced death.	malonic acid	130-138	cannabinoid receptor 2	Rattus norvegicus	56-59
19115380-5	2009	CB2 receptors are scarce in the striatum in healthy conditions, but they are markedly upregulated after the lesion with malonate.	malonic acid	120-128	cannabinoid receptor 2 (macrophage)	Mus musculus	0-3
19115380-7	2009	We further showed that the activation of CB2 receptors significantly reduced the levels of tumor necrosis factor-alpha (TNF-alpha) that had been increased by the lesion with malonate.	malonic acid	174-182	cannabinoid receptor 2 (macrophage)	Mus musculus	41-44
19115380-7	2009	We further showed that the activation of CB2 receptors significantly reduced the levels of tumor necrosis factor-alpha (TNF-alpha) that had been increased by the lesion with malonate.	malonic acid	174-182	tumor necrosis factor	Mus musculus	91-118
19115380-7	2009	We further showed that the activation of CB2 receptors significantly reduced the levels of tumor necrosis factor-alpha (TNF-alpha) that had been increased by the lesion with malonate.	malonic acid	174-182	tumor necrosis factor	Mus musculus	120-129
19115380-8	2009	In summary, our results demonstrate that stimulation of CB2 receptors protect the striatum against malonate toxicity, likely through a mechanism involving glial cells, in particular reactive microglial cells in which CB2 receptors would be upregulated in response to the lesion.	malonic acid	99-107	cannabinoid receptor 2 (macrophage)	Mus musculus	56-59
19115380-8	2009	In summary, our results demonstrate that stimulation of CB2 receptors protect the striatum against malonate toxicity, likely through a mechanism involving glial cells, in particular reactive microglial cells in which CB2 receptors would be upregulated in response to the lesion.	malonic acid	99-107	cannabinoid receptor 2 (macrophage)	Mus musculus	217-220
18039180-1	2008	Screening of the Arabidopsis thaliana genome revealed three potential homologues of mammalian and yeast mitochondrial DICs (dicarboxylate carriers) designated as DIC1, DIC2 and DIC3, each belonging to the mitochondrial carrier protein family.	malonic acid	124-137	Dic1p	Saccharomyces cerevisiae S288C	162-166
19122194-8	2009	Catalytic subunits (SDH1, SDH2N plus SDH2C, SDH3, and SDH4) contain all key residues for binding of dicarboxylates and quinones, but the enzyme showed the lower affinity for both substrates and inhibitors than mammalian enzymes.	malonic acid	100-114	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	20-24
19122194-8	2009	Catalytic subunits (SDH1, SDH2N plus SDH2C, SDH3, and SDH4) contain all key residues for binding of dicarboxylates and quinones, but the enzyme showed the lower affinity for both substrates and inhibitors than mammalian enzymes.	malonic acid	100-114	succinate dehydrogenase complex subunit C	Homo sapiens	44-48
19122194-8	2009	Catalytic subunits (SDH1, SDH2N plus SDH2C, SDH3, and SDH4) contain all key residues for binding of dicarboxylates and quinones, but the enzyme showed the lower affinity for both substrates and inhibitors than mammalian enzymes.	malonic acid	100-114	succinate dehydrogenase complex subunit D	Homo sapiens	54-58
19007212-1	2008	Spin-unrestricted time-dependent density functional theory has been applied to the electronic circular dichroism spectra of Cr(III) complexes with an open-shell ground state, that is, [Cr(L-L)(3)](n+) with L-L = en(ethylenediamine), acac(acetylacetonate), ox(oxalate), mal(malonate), and Thiox(dithiooxalate).	malonic acid	273-281	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	127-130
18609448-5	2008	Glutaric acid, a model dicarboxylate, trans-stimulated the uptake of [(14)C]zonampanel by OAT4, suggesting that zonampanel was transported by OAT4 via an exchange with dicarboxylate.	malonic acid	23-36	solute carrier family 22 member 11	Homo sapiens	90-94
18609448-6	2008	Considering the endogenous dicarboxylate gradient, OAT4 seems to transport zonampanel in the direction of reabsorption rather than secretion.	malonic acid	27-40	solute carrier family 22 member 11	Homo sapiens	51-55
18374655-1	2008	Glutathione (GSH) is transported into renal mitochondria by the dicarboxylate (DIC; Slc25a10) and 2-oxoglutarate carriers (OGC; Slc25a11).	malonic acid	64-77	solute carrier family 25 member 10	Rattus norvegicus	79-82
18374655-1	2008	Glutathione (GSH) is transported into renal mitochondria by the dicarboxylate (DIC; Slc25a10) and 2-oxoglutarate carriers (OGC; Slc25a11).	malonic acid	64-77	solute carrier family 25 member 10	Rattus norvegicus	84-92
19251849-9	2009	Mutants lacking mqo function grow more slowly in culture than wild-type bacteria when dicarboxylates are the only available carbon source.	malonic acid	86-100	malate dehydrogenase (quinone)	Pseudomonas syringae pv. tomato str. DC3000	16-19
19251849-11	2009	DC3000 mutants lacking dctA1 do not grow to wild-type levels in planta, indicating that transport and utilization of dicarboxylates are important for virulence of DC3000.	malonic acid	117-131	dicarboxylate/amino acid:cation symporter	Pseudomonas syringae pv. tomato str. DC3000	23-28
19378558-2	2009	Homoleptic eight-coordinated monomeric compounds of the type ML4 were obtained for Hf with all the malonate ligands employed.	malonic acid	99-107	mucolipin TRP cation channel 1	Homo sapiens	61-64
18682385-2	2008	Recombinant and reconstituted mitochondrial oxalacetate carrier (Oac1p) efficiently transported alpha-IPM in addition to its known substrates oxalacetate, sulfate, and malonate and in contrast to other di- and tricarboxylate transporters as well as the previously proposed alpha-IPM transporter.	malonic acid	168-176	Oac1p	Saccharomyces cerevisiae S288C	65-70
18654694-1	2008	Thermally denatured chymotrypsin, lysozyme and papain are substantially refolded towards their native conformation by gold nanoparticle bearing dicarboxylate sidechains.	malonic acid	144-157	lysozyme	Homo sapiens	34-42
18039180-1	2008	Screening of the Arabidopsis thaliana genome revealed three potential homologues of mammalian and yeast mitochondrial DICs (dicarboxylate carriers) designated as DIC1, DIC2 and DIC3, each belonging to the mitochondrial carrier protein family.	malonic acid	124-137	dicarboxylate carrier 2	Arabidopsis thaliana	168-172
17257042-6	2007	On the contrary, K2(suc) and K2(dmmal) yielded preferentially the dinuclear species [fac-Ru(DMSO-S)3(H2O)(mu-dicarb)]2 (dicarb = dmmal, 11; suc, 13), with two bridging dicarboxylate moieties.	malonic acid	168-181	RBPJ pseudogene 3	Homo sapiens	17-24
18044850-4	2007	The temperature dependence of the vapor pressures was obtained as least-squares fits to the derived vapor pressures: ln(Psat,l) (Pa)=220.2389-22634.96/T (K)-26.66767 ln T (K) for malonic acid and ln(Psat,l) (Pa)=140.6704-18230.97/T (K)-15.48011 ln T (K) for adipic acid.	malonic acid	179-191	phosphoserine aminotransferase 1	Homo sapiens	120-124
18044850-4	2007	The temperature dependence of the vapor pressures was obtained as least-squares fits to the derived vapor pressures: ln(Psat,l) (Pa)=220.2389-22634.96/T (K)-26.66767 ln T (K) for malonic acid and ln(Psat,l) (Pa)=140.6704-18230.97/T (K)-15.48011 ln T (K) for adipic acid.	malonic acid	179-191	phosphoserine aminotransferase 1	Homo sapiens	199-203
17172466-0	2007	Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.	malonic acid	152-160	mitogen-activated protein kinase 14	Homo sapiens	28-64
17172466-0	2007	Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.	malonic acid	152-160	BCL2 associated X, apoptosis regulator	Homo sapiens	74-77
17172466-0	2007	Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.	malonic acid	152-160	cytochrome c, somatic	Homo sapiens	102-114
17172466-2	2007	We have shown previously that malonate increased reactive oxygen species (ROS) production in human SH-SY5Y neuroblastoma cells, leading to oxidative stress, cytochrome c release, and apoptotic cell death.	malonic acid	30-38	cytochrome c, somatic	Homo sapiens	157-169
17172466-3	2007	Expression of a green fluorescent protein-Bax fusion protein in SH-SY5Y neuroblastoma cells demonstrated a Bax redistribution from the cytosol to mitochondria after 12 to 24 h of malonate treatment that coincided with mitochondrial potential collapse and chromatin condensation.	malonic acid	179-187	BCL2 associated X, apoptosis regulator	Homo sapiens	42-45
17172466-3	2007	Expression of a green fluorescent protein-Bax fusion protein in SH-SY5Y neuroblastoma cells demonstrated a Bax redistribution from the cytosol to mitochondria after 12 to 24 h of malonate treatment that coincided with mitochondrial potential collapse and chromatin condensation.	malonic acid	179-187	BCL2 associated X, apoptosis regulator	Homo sapiens	107-110
17172466-4	2007	Inhibition of Bax translocation using furosemide, as well as Bax gene deletion, afforded significant protection against malonate-induced apoptosis.	malonic acid	120-128	BCL2 associated X, apoptosis regulator	Homo sapiens	14-17
17172466-4	2007	Inhibition of Bax translocation using furosemide, as well as Bax gene deletion, afforded significant protection against malonate-induced apoptosis.	malonic acid	120-128	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64
17172466-5	2007	Further experiments revealed that malonate induced a prominent increase in the level of activated p38 mitogen-activated protein (MAP) kinase and that treatment with the p38 MAP kinase inhibitor SKF86002 potently blocked malonate-induced Bax translocation and apoptosis.	malonic acid	34-42	mitogen-activated protein kinase 14	Homo sapiens	98-101
17172466-5	2007	Further experiments revealed that malonate induced a prominent increase in the level of activated p38 mitogen-activated protein (MAP) kinase and that treatment with the p38 MAP kinase inhibitor SKF86002 potently blocked malonate-induced Bax translocation and apoptosis.	malonic acid	34-42	BCL2 associated X, apoptosis regulator	Homo sapiens	237-240
17172466-5	2007	Further experiments revealed that malonate induced a prominent increase in the level of activated p38 mitogen-activated protein (MAP) kinase and that treatment with the p38 MAP kinase inhibitor SKF86002 potently blocked malonate-induced Bax translocation and apoptosis.	malonic acid	220-228	mitogen-activated protein kinase 14	Homo sapiens	98-101
17172466-5	2007	Further experiments revealed that malonate induced a prominent increase in the level of activated p38 mitogen-activated protein (MAP) kinase and that treatment with the p38 MAP kinase inhibitor SKF86002 potently blocked malonate-induced Bax translocation and apoptosis.	malonic acid	220-228	mitogen-activated protein kinase 14	Homo sapiens	169-183
17172466-5	2007	Further experiments revealed that malonate induced a prominent increase in the level of activated p38 mitogen-activated protein (MAP) kinase and that treatment with the p38 MAP kinase inhibitor SKF86002 potently blocked malonate-induced Bax translocation and apoptosis.	malonic acid	220-228	BCL2 associated X, apoptosis regulator	Homo sapiens	237-240
17172466-7	2007	Our data suggest that malonate-induced ROS production and subsequent p38 MAP kinase activation mediates the activation of the pro-apoptotic Bax protein to induce mitochondrial membrane permeabilization and neuronal apoptosis.	malonic acid	22-30	mitogen-activated protein kinase 14	Homo sapiens	69-72
17172466-7	2007	Our data suggest that malonate-induced ROS production and subsequent p38 MAP kinase activation mediates the activation of the pro-apoptotic Bax protein to induce mitochondrial membrane permeabilization and neuronal apoptosis.	malonic acid	22-30	BCL2 associated X, apoptosis regulator	Homo sapiens	140-143
17257042-5	2007	Likewise, when 3 was used as a precursor, the neutral mononuclear species fac-[Ru(DMSO-O)(DMSO-S)3(eta2-dicarb)] (dicarb = mal, 7; mmal, 10; ox, 16), which contains a DMSO-O ligand in the place of Cl-, was obtained.	malonic acid	123-126	DNA polymerase iota	Homo sapiens	99-103
18198353-5	2008	4E-BP2 ASO-treated mice showed >8.5% increase in metabolic rate, >40% increase in UCP1 levels in BAT, >45% increase in beta(3)-adrenoceptor mRNA, and 40-55% decrease in mitochondrial dicarboxylate carrier, fatty acid synthase, and diacylglycerol acyltransferase 2 mRNA levels in WAT.	malonic acid	192-205	EBNA1 binding protein 2	Mus musculus	1-6
18338640-2	2007	Using succinate and malonate as zinc binding groups and long hydrophobic substituents to bind with S1" pockets, the compounds showed micromolar inhibition and selectivity for MMP-2 over others.	malonic acid	20-28	matrix metallopeptidase 2	Homo sapiens	175-180
17919343-6	2007	Inhibitors of respiratory chain-mediated H2O2 production, malonate and carbonyl cyanide-4-(trifluoromethoxy)-phenylhydrazone (FCCP), inhibited both insulin-stimulated H2O2 release from neurons and insulin-stimulated autophosphorylation of insulin receptor.	malonic acid	58-66	insulin	Homo sapiens	148-155
17919343-6	2007	Inhibitors of respiratory chain-mediated H2O2 production, malonate and carbonyl cyanide-4-(trifluoromethoxy)-phenylhydrazone (FCCP), inhibited both insulin-stimulated H2O2 release from neurons and insulin-stimulated autophosphorylation of insulin receptor.	malonic acid	58-66	insulin	Homo sapiens	197-204
17919343-6	2007	Inhibitors of respiratory chain-mediated H2O2 production, malonate and carbonyl cyanide-4-(trifluoromethoxy)-phenylhydrazone (FCCP), inhibited both insulin-stimulated H2O2 release from neurons and insulin-stimulated autophosphorylation of insulin receptor.	malonic acid	58-66	insulin	Homo sapiens	197-204
17257042-6	2007	On the contrary, K2(suc) and K2(dmmal) yielded preferentially the dinuclear species [fac-Ru(DMSO-S)3(H2O)(mu-dicarb)]2 (dicarb = dmmal, 11; suc, 13), with two bridging dicarboxylate moieties.	malonic acid	168-181	RBPJ pseudogene 3	Homo sapiens	20-23
17257042-8	2007	The solid-state X-ray structural data showed that the preferential binding mode of the investigated dicarboxylates, either bridging (mu) or chelating (eta2), is dictated mainly by steric reasons.	malonic acid	100-114	DNA polymerase iota	Homo sapiens	151-155
17220594-6	2007	Thus, mOat3 was shown to mediate the bidirectional transport of PGE(2), partly coupled to the dicarboxylate exchange mechanism.	malonic acid	94-107	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	6-11
17090704-4	2007	We presently report that the malonate-induced DA efflux is partially mediated by reverse transport of DA from the cytosol to the extracellular space via the DA transporter (DAT).	malonic acid	29-37	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	157-171
17090704-4	2007	We presently report that the malonate-induced DA efflux is partially mediated by reverse transport of DA from the cytosol to the extracellular space via the DA transporter (DAT).	malonic acid	29-37	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	173-176
17090704-6	2007	Consistent with these findings, the DAT inhibitors prevented malonate-induced damage to DA neurons in mesencephalic cultures and also protected against the loss of GABA neurons in this system.	malonic acid	61-69	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	36-39
17220594-6	2007	Thus, mOat3 was shown to mediate the bidirectional transport of PGE(2), partly coupled to the dicarboxylate exchange mechanism.	malonic acid	94-107	prostaglandin E synthase 2 S homeolog	Xenopus laevis	64-70
16759857-1	2006	The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta.	malonic acid	78-86	protein tyrosine phosphatase receptor type B	Homo sapiens	148-156
16600197-5	2006	Indeed, studies by Lash and colleagues in isolated mitochondria from rat kidney showed that most of the transport (>80%) in that tissue could be accounted for by function of the dicarboxylate carrier (DIC, Slc25a10) and the oxoglutarate carrier (OGC, Slc25a11), which mediate electroneutral exchange of dicarboxylates for inorganic phosphate and 2-oxoglutarate for other dicarboxylates, respectively.	malonic acid	181-194	solute carrier family 25 member 11	Rattus norvegicus	254-262
18309926-5	2007	In order to achieve a systemic upregulation of antioxidant potential in local striatal region, a cell-based, Nrf2-dependent antioxidant gene therapy is performed to attenuate malonate-induced neuronal cell death.	malonic acid	175-183	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
16484232-1	2006	The Escherichia coli complex II homologues succinate:ubiquinone oxidoreductase (SQR, SdhCDAB) and menaquinol:fumarate oxidoreductase (QFR, FrdABCD) have remarkable structural homology at their dicarboxylate binding sites.	malonic acid	193-206	oxidoreductase	Escherichia coli	64-78
16478971-9	2006	Accumulation of estrone sulfate mediated by mOat6 was significantly trans-stimulated by glutarate, indicating that mOat6 functions as an organic anion/dicarboxylate exchanger.	malonic acid	151-164	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	44-49
16478971-9	2006	Accumulation of estrone sulfate mediated by mOat6 was significantly trans-stimulated by glutarate, indicating that mOat6 functions as an organic anion/dicarboxylate exchanger.	malonic acid	151-164	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	115-120
16832499-2	2006	The complexes were synthesized by partially replacing the amido groups from the complexes [Ti(NMe2)4] and [Ti(NEt2)4] via Bronstedt acid/base reactions, using the malonate-ligands di-isopropylmalonate (Hdpml) and di-tert-butylmalonate (Hdbml).	malonic acid	163-171	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	94-98
16819824-4	2006	Upon formation of the PEPCK-Mn2+-PEP or PEPCK-Mn2+-malonate-Mn2+ GDP complexes, C307 coordination is lost as the P-loop in which it resides adopts a different conformation.	malonic acid	51-59	progestagen associated endometrial protein	Homo sapiens	22-25
16819824-4	2006	Upon formation of the PEPCK-Mn2+-PEP or PEPCK-Mn2+-malonate-Mn2+ GDP complexes, C307 coordination is lost as the P-loop in which it resides adopts a different conformation.	malonic acid	51-59	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	40-45
16819824-6	2006	A third conformation of the mobile P-loop in the PEPCK-Mn2+-malonate-Mn2+ GDP complex demonstrates the participation of a previously unrecognized, conserved serine residue (S305) in mediating phosphoryl transfer.	malonic acid	60-68	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	49-54
16819824-7	2006	The ordering of the mobile active site lid in the PEPCK-Mn2+-malonate-Mn2+ GDP complex yields the first observation of this structural feature and provides additional insight into the mechanism of phosphoryl transfer.	malonic acid	61-69	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	50-55
16763307-2	2006	The Ca(II) cation, lying on a twofold axis, is coordinated by two water molecules and six malonate O atoms.	malonic acid	90-98	carbonic anhydrase 2	Homo sapiens	4-10
16458060-3	2006	The SERS spectral features indicated that the RSPSA molecules should bound to the silver as dicarboxylate, with a strongly tilted orientation with respect to the normal to the surface.	malonic acid	92-105	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
16455258-3	2006	Three of them, two isosteric carboxylate analogues and a malonate derivative, showed a binding affinity for the M6P/IGF2R equivalent to or higher than that of M6P.	malonic acid	57-65	insulin like growth factor 2 receptor	Homo sapiens	112-121
16484232-1	2006	The Escherichia coli complex II homologues succinate:ubiquinone oxidoreductase (SQR, SdhCDAB) and menaquinol:fumarate oxidoreductase (QFR, FrdABCD) have remarkable structural homology at their dicarboxylate binding sites.	malonic acid	193-206	oxidoreductase	Escherichia coli	118-132
16516867-9	2006	This is the first report demonstrating the molecular identity of the Na+ -coupled di/tricarboxylate transport system expressed in neurons as NaC2/NaCT, which can transport the tricarboxylate citrate as well as dicarboxylates such as succinate, alpha-ketoglutarate, and malate.	malonic acid	210-224	nucleus accumbens associated 2, BEN and BTB (POZ) domain containing	Mus musculus	141-145
16516867-9	2006	This is the first report demonstrating the molecular identity of the Na+ -coupled di/tricarboxylate transport system expressed in neurons as NaC2/NaCT, which can transport the tricarboxylate citrate as well as dicarboxylates such as succinate, alpha-ketoglutarate, and malate.	malonic acid	210-224	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	146-150
16518487-0	2006	Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative.	malonic acid	60-68	BOC cell adhesion associated, oncogene regulated	Homo sapiens	97-100
16298531-5	2006	We found that alpha-synuclein-deficient mice are also resistant to both malonate and 3-nitropropionic acid (3-NP) neurotoxicity.	malonic acid	72-80	synuclein, alpha	Mus musculus	14-29
16537407-2	2006	We synthesized a series of antagonists of GHRH(1-29)NH(2) acylated at the N terminus with monocarboxylic or alpha,omega-dicarboxylic acids containing six to sixteen carbon atoms.	malonic acid	108-138	growth hormone releasing hormone	Homo sapiens	42-46
16291728-1	2006	We previously showed that two anion carriers of the mitochondrial inner membrane, the dicarboxylate carrier (DIC; Slc25a10) and oxoglutarate carrier (OGC; Slc25a11), transport glutathione (GSH) from cytoplasm into mitochondrial matrix.	malonic acid	86-99	solute carrier family 25 member 10	Rattus norvegicus	114-122
16185077-0	2005	Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity.	malonic acid	98-111	serine racemase	Mus musculus	49-64
16079298-11	2005	These results indicate that rOat5 is renal organic anion/dicarboxylates exchanger and, under physiological conditions, may function as an apical reabsorptive pathway for organic anions in proximal tubules driven by an outward gradient of dicarboxylates.	malonic acid	57-71	solute carrier family 22, member 24	Rattus norvegicus	28-33
16242643-12	2005	In addition, malonate-induced down-regulation of the antiapoptotic gene Bcl-2 was not prevented by minocycline, controversially the mechanism previously proposed to explain minocycline protective action.	malonic acid	13-21	BCL2, apoptosis regulator	Rattus norvegicus	72-77
16027120-1	2005	Mitochondrial solute carrier family 25 member 10 (Slc25a10) transports dicarboxylates such as malate or succinate across the mitochondrial inner membrane.	malonic acid	71-85	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	Mus musculus	50-58
16004976-3	2005	Injection of malonate at a dose of 3 mumol unilaterally into the rat left medial forebrain bundle resulted in the 54% decrease in dopamine (DA) concentration in the ipsilateral striatum and, depending on the examined striatum regions, caused 24-44% reduction in [3H]GBR12,935 binding to the dopamine transporter (DAT).	malonic acid	13-21	solute carrier family 6 member 3	Rattus norvegicus	291-311
16004976-3	2005	Injection of malonate at a dose of 3 mumol unilaterally into the rat left medial forebrain bundle resulted in the 54% decrease in dopamine (DA) concentration in the ipsilateral striatum and, depending on the examined striatum regions, caused 24-44% reduction in [3H]GBR12,935 binding to the dopamine transporter (DAT).	malonic acid	13-21	solute carrier family 6 member 3	Rattus norvegicus	313-316
15692145-1	2005	The human organic anion transporter 2 (hOAT2, SLC22A7) mediates the sodium-independent uptake of numerous drugs, including cephalosporins, salicylates, dicarboxylates, and prostaglandins, and is mainly expressed in hepatocytes.	malonic acid	152-166	solute carrier family 22 member 7	Homo sapiens	10-37
15692145-1	2005	The human organic anion transporter 2 (hOAT2, SLC22A7) mediates the sodium-independent uptake of numerous drugs, including cephalosporins, salicylates, dicarboxylates, and prostaglandins, and is mainly expressed in hepatocytes.	malonic acid	152-166	solute carrier family 22 member 7	Homo sapiens	39-44
15692145-1	2005	The human organic anion transporter 2 (hOAT2, SLC22A7) mediates the sodium-independent uptake of numerous drugs, including cephalosporins, salicylates, dicarboxylates, and prostaglandins, and is mainly expressed in hepatocytes.	malonic acid	152-166	solute carrier family 22 member 7	Homo sapiens	46-53
15561973-11	2005	The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 or 3.	malonic acid	68-81	solute carrier family 13 member 3	Homo sapiens	102-109
15561973-11	2005	The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 or 3.	malonic acid	68-81	solute carrier family 22 member 6	Homo sapiens	219-251
15655518-15	2005	Further permeability transition pore opening and the subsequent release of proapoptotic factors such as Cyt c could therefore be, at least in part, responsible for malonate-induced toxicity.	malonic acid	164-172	cytochrome c, somatic	Homo sapiens	104-109
16018587-9	2005	Succinate dehydrogenase (SDH) was inhibited by malonate but not by QA.	malonic acid	47-55	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
16018587-9	2005	Succinate dehydrogenase (SDH) was inhibited by malonate but not by QA.	malonic acid	47-55	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
15728336-3	2005	To identify putative metabolic changes in AttDT knock-out plants, we provoked a metabolic scenario connected to an increased consumption of dicarboxylates.	malonic acid	140-154	tonoplast dicarboxylate transporter	Arabidopsis thaliana	42-47
15728336-12	2005	In conclusion, these results show that Arabidopsis vacuoles contain at least two transporters and a channel for dicarboxylates and citrate and that the activity of AttDT is critical for regulation of pH homeostasis.	malonic acid	112-126	tonoplast dicarboxylate transporter	Arabidopsis thaliana	164-169
15664815-3	2005	The cytosolic isozyme hCA I was strongly activated by acetate, oxalate, pyruvate, l-lactate, and citrate (K(A) around 0.1 microM), whereas formate, malonate, malate, and benzoate were weaker activators (K(A) in the range 0.1-1mM).	malonic acid	148-156	carbonic anhydrase 1	Homo sapiens	22-27
15664815-5	2005	The membrane-associated isozyme hCA IV was the most sensitive to inhibition by carboxylates, showing a K(I) of 99 nM for citrate and oxalate, of 2.8 microM for malonate and of 14.5 microM for pyruvate among others.	malonic acid	160-168	carbonic anhydrase 4	Homo sapiens	32-38
15655518-4	2005	Malonate induces mitochondrial potential collapse, mitochondrial swelling, cytochrome c (Cyt c) release and depletes glutathione (GSH) and nicotinamide adenine dinucleotide coenzyme (NAD(P)H) stores in brain-isolated mitochondria.	malonic acid	0-8	cytochrome c, somatic	Homo sapiens	75-87
15655518-4	2005	Malonate induces mitochondrial potential collapse, mitochondrial swelling, cytochrome c (Cyt c) release and depletes glutathione (GSH) and nicotinamide adenine dinucleotide coenzyme (NAD(P)H) stores in brain-isolated mitochondria.	malonic acid	0-8	cytochrome c, somatic	Homo sapiens	89-94
15655518-9	2005	Malonate added to SH-SY5Y cell cultures produced a marked loss of cell viability together with the release of Cyt c and depletion of GSH and NAD(P)H concentrations.	malonic acid	0-8	cytochrome c, somatic	Homo sapiens	110-115
15608338-7	2005	Exogenous malonate, which feeds into the carboxylation pathway of acetyl-CoA metabolism, chemically complements the morphological and chemical alterations associated with reduced ACL expression, indicating that the observed metabolic alterations are related to the carboxylation pathway of cytosolic acetyl-CoA metabolism.	malonic acid	10-18	acetone-cyanohydrin lyase	Arabidopsis thaliana	179-182
15611470-3	2005	We found that Nrf2-deficient cells and Nrf2 knockout mice are significantly more vulnerable to malonate and 3NP and demonstrate increased antioxidant response element (ARE)-regulated transcription mediated by astrocytes.	malonic acid	95-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
15611470-3	2005	We found that Nrf2-deficient cells and Nrf2 knockout mice are significantly more vulnerable to malonate and 3NP and demonstrate increased antioxidant response element (ARE)-regulated transcription mediated by astrocytes.	malonic acid	95-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	malonic acid	202-210	acetone-cyanohydrin lyase	Arabidopsis thaliana	70-73
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	malonic acid	202-210	acetone-cyanohydrin lyase	Arabidopsis thaliana	225-228
15124099-3	2004	Triterpenoids esterified with malonic acid at C-3 possessed the strongest hemolytic activity among the tested compounds.	malonic acid	30-42	complement C3	Homo sapiens	46-49
15480454-4	2004	For oxalate, malonate, benzoate and dibenzoate anions only the beta2 constants could be obtained.	malonic acid	13-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	63-68
15296730-0	2004	Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.	malonic acid	40-48	caspase 1	Homo sapiens	61-70
15088065-6	2004	Interestingly, significant metabolic complementation of the mutant phenotype was obtained by exogenous supply of malonate, suggesting that the lack of cytosolic malonyl-CoA is likely to be the initial factor leading to abnormal development in the acc1 mutants.	malonic acid	113-121	acetyl-CoA carboxylase ACC1	Saccharomyces cerevisiae S288C	247-251
15037815-8	2004	These results indicate that OAT4 is an apical organic anion/dicarboxylate exchanger and mainly functions as an apical pathway for the reabsorption of some organic anions in renal proximal tubules driven by an outwardly directed dicarboxylate gradient.	malonic acid	60-73	solute carrier family 22 member 11	Homo sapiens	28-32
15050711-0	2004	Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method.	malonic acid	19-27	mitogen-activated protein kinase 8	Rattus norvegicus	94-117
15050711-2	2004	Malonate, which produces lesions similar to those of focal ischemia-reperfusion by a reversible inhibition of succinate dehydrogenase in mitochondria, was injected into the left striatum in the rat brain without or with the simultaneous injection of a cell permeable peptidic JNK inhibitor, (L)-HIV-TAT48-57-PP-JBD20.	malonic acid	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	276-279
15098936-0	2004	Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice.	malonic acid	72-80	monoamine oxidase A	Rattus norvegicus	124-129
15098936-1	2004	Intrastriatal administration of the succinate dehydrogenase (SDH) inhibitor malonate produces neuronal injury by a "secondary excitotoxic" mechanism involving the generation of reactive oxygen species (ROS).	malonic acid	76-84	aminoadipate-semialdehyde synthase	Mus musculus	36-59
15098936-1	2004	Intrastriatal administration of the succinate dehydrogenase (SDH) inhibitor malonate produces neuronal injury by a "secondary excitotoxic" mechanism involving the generation of reactive oxygen species (ROS).	malonic acid	76-84	aminoadipate-semialdehyde synthase	Mus musculus	61-64
15098936-7	2004	In rats treated with either of the specific MAO-A or -B inhibitors, clorgyline or deprenyl, respectively, malonate lesion volumes were reduced by 30% compared to controls.	malonic acid	106-114	monoamine oxidase A	Mus musculus	44-49
15098936-8	2004	In knock-out mice lacking the MAO-A isoform, malonate-induced lesions were reduced by 50% and protein carbonyls, an index ROS formation, were reduced by 11%, compared to wild-type animals.	malonic acid	45-53	monoamine oxidase A	Mus musculus	30-35
15098936-9	2004	In contrast, mice deficient in MAO-B showed highly variable susceptibility to malonate toxicity precluding us from determining the precise role of MAO-B in this form of brain damage.	malonic acid	78-86	monoamine oxidase B	Mus musculus	31-36
15098936-10	2004	These findings indicate that normal levels of MAO-A participate in expression of malonate toxicity by a mechanism involving oxidative stress.	malonic acid	81-89	monoamine oxidase A	Mus musculus	46-51
12837685-2	2003	In this study, we used electrophysiology, kinetic measurements, and static head experiments to determine the coupling ratio for Oat1-mediated organic anion/dicarboxylate exchange.	malonic acid	156-169	solute carrier family 22 member 6	Rattus norvegicus	128-132
14969746-3	2004	We show that malonate stress increases the number of dead or dying cells when organotypic slice cultures are transduced to express pathological-length huntingtin fragments.	malonic acid	13-21	huntingtin	Homo sapiens	151-161
14744804-14	2004	These data provide in vivo proof-of-concept of the neuroprotective effects of reversible caspase-3 inhibitors in a model of malonate-induced striatal injury in the adult rat.	malonic acid	124-132	caspase 3	Rattus norvegicus	89-98
14501124-0	2003	Crystallization of the PX domain of cytokine-independent survival kinase (CISK): improvement of crystal quality for X-ray diffraction with sodium malonate.	malonic acid	139-154	serum/glucocorticoid regulated kinase 3	Mus musculus	36-72
14501124-0	2003	Crystallization of the PX domain of cytokine-independent survival kinase (CISK): improvement of crystal quality for X-ray diffraction with sodium malonate.	malonic acid	139-154	serum/glucocorticoid regulated kinase 3	Mus musculus	74-78
14501124-6	2003	In this study, the use of sodium malonate is the key to both successful crystallization and cryoprotection of the PX domain of CISK.	malonic acid	26-41	serum/glucocorticoid regulated kinase 3	Mus musculus	127-131
12837685-9	2003	When stoichiometry was assessed using plasma membranes isolated from the hOAT1-expressing cells, both kinetic and static head data indicated that hOAT1 also demonstrated a 1:1 coupling between organic anion and dicarboxylate.	malonic acid	211-224	solute carrier family 22 member 6	Homo sapiens	146-151
12774021-8	2003	In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle.	malonic acid	234-247	transthyretin	Mus musculus	100-103
12774021-8	2003	In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle.	malonic acid	234-247	forkhead box A2	Mus musculus	104-109
12910308-2	2003	Injection of SDH inhibitor (sodium malonate) inhibited gas exchange and abolished the effect of sodium succinate.	malonic acid	28-43	serine dehydratase	Rattus norvegicus	13-16
12691560-0	2003	Syntheses of two new 1D and 3D networks of Cu(II) and Co(II) using malonate and urotropine as bridging ligands: crystal structures and magnetic studies.	malonic acid	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
12606766-7	2003	Toxicity of this conjugate was reduced by the OAT1-exchangeable dicarboxylates alpha-ketoglutarate, glutarate, and adipate, but not by succinate, a nonexchangeable dicarboxylate.	malonic acid	64-77	solute carrier family 22 member 6	Homo sapiens	46-50
12093104-6	2002	Compared to HSP-70+/+ and HSP-70+/-, wild-type controls showed significantly larger striatal lesions following 3-NP or malonate injections.	malonic acid	119-127	heat shock protein 1B	Mus musculus	26-32
12298006-3	2002	NMR studies on palladium eta(3)-1,3-diphenylallyl intermediates (11 a, c and e) showed the presence of syn/syn- and syn/anti-allyl isomers in solution; this resembles the first example of eta(3)-eta(1)-eta(3) isomerism in Pd allylic complexes containing bis(oxazolines) derived from malonic acid.	malonic acid	283-295	synemin	Homo sapiens	107-110
12298006-3	2002	NMR studies on palladium eta(3)-1,3-diphenylallyl intermediates (11 a, c and e) showed the presence of syn/syn- and syn/anti-allyl isomers in solution; this resembles the first example of eta(3)-eta(1)-eta(3) isomerism in Pd allylic complexes containing bis(oxazolines) derived from malonic acid.	malonic acid	283-295	synemin	Homo sapiens	107-110
12697169-12	2003	We believe that intracellular esterases generate the corresponding dicarboxylate, which is a potent PP1 and PP2A inhibitor, and that it is this species which is responsible for the observed anti-cancer activity.	malonic acid	67-80	inorganic pyrophosphatase 1	Homo sapiens	100-103
12697169-12	2003	We believe that intracellular esterases generate the corresponding dicarboxylate, which is a potent PP1 and PP2A inhibitor, and that it is this species which is responsible for the observed anti-cancer activity.	malonic acid	67-80	protein phosphatase 2 phosphatase activator	Homo sapiens	108-112
14586168-6	2003	METHODS: The human OAT3 obtained Xenopus laevis oocyte expression system, hOAT3-mediated transport of estrone sulfate (ES) and dicarboxylates was assayed for cis-inhibition and/or trans-stimulation in both the uptake and efflux direction.	malonic acid	127-141	solute carrier family 22 member 8	Homo sapiens	74-79
12298006-3	2002	NMR studies on palladium eta(3)-1,3-diphenylallyl intermediates (11 a, c and e) showed the presence of syn/syn- and syn/anti-allyl isomers in solution; this resembles the first example of eta(3)-eta(1)-eta(3) isomerism in Pd allylic complexes containing bis(oxazolines) derived from malonic acid.	malonic acid	283-295	synemin	Homo sapiens	103-106
12093104-4	2002	In this study, we examined whether the 70-kDa heat shock protein (HSP-70) is protective against neurotoxicity induced by malonate and 3-NP.	malonic acid	121-129	heat shock protein 1B	Mus musculus	66-72
11800230-5	2001	The spectral changes indicate that the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca- in the malonate chelation mode, where a Ca2+ interacts with two oxygen atoms, one from each of the two COO- groups of a single gamma-carboxyglutamic acid residue.	malonic acid	118-126	bone gamma-carboxyglutamate protein	Homo sapiens	81-92
12024022-5	2002	This phenotype was partially rescued by malonic acid, indicating that reactive oxygen species generated by the electron transport chain contribute to mitochondrial dysfunction in abf2 Delta strains.	malonic acid	40-52	DNA-binding protein ABF2	Saccharomyces cerevisiae S288C	179-183
12051770-4	2002	The data indicate that there are Mrp2-independent mechanisms in the rat for biliary excretion of dicarboxylate organic anions related to biliverdin.	malonic acid	97-110	ATP binding cassette subfamily C member 2	Rattus norvegicus	33-37
11595758-4	2001	Prior lesions of the nigrostriatal pathway with 6-OHDA or the depletion of striatal dopamine stores by pretreatment with reserpine, an inhibitor or the vesicular monoamine transporter type-2 (VMAT2), in combination with alpha-methyl-p-tyrosine resulted in a significant reduction of malonate-induced striatal lesion volumes.	malonic acid	283-291	solute carrier family 18 member A2	Rattus norvegicus	192-197
11161534-3	2001	In the absence of Pb(II), ATR-FTIR measurements of sorbed malonate suggest the formation of more than one malonate surface complex.	malonic acid	106-114	ATR serine/threonine kinase	Homo sapiens	26-29
11526017-10	2001	This suggests that, in S. cerevisiae, either there is a proton counterflow or the Mae1p permease functions differently from a proton/dicarboxylate symport.	malonic acid	133-146	malate dehydrogenase (oxaloacetate-decarboxylating)	Saccharomyces cerevisiae S288C	82-87
11463328-3	2001	In an analogous fashion, ketoester- and malonate-substituted carbenoids have been found to insert into C-2 thioindoles.	malonic acid	40-48	complement C2	Homo sapiens	103-106
11408160-3	2001	Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111.	malonic acid	74-82	selectin P	Homo sapiens	172-182
11287335-4	2001	The mNaDC-3 transporter has a broad substrate specificity for dicarboxylates, including succinate, alpha-ketoglutarate, fumarate, malate, and dimethylsuccinate.	malonic acid	62-76	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	Mus musculus	4-11
11161534-2	2001	Pb L(III)-edge EXAFS measurements performed in the presence of malonate indicate the presence of both Fe and C neighbors, suggesting that a major fraction of surface-bound malonate is bonded to adsorbed Pb(II).	malonic acid	172-180	submaxillary gland androgen regulated protein 3B	Homo sapiens	203-209
11288487-6	2001	OAT1 mediates sodium-independent, anion exchange for a variety of organic anions including p-aminohippurate, cyclic nucleotides, prostanoides, dicarboxylates, and anionic drugs including beta-lactams, non-steroidal antiinflammatory drugs, diuretics and antiviral drugs.	malonic acid	143-157	solute carrier family 22 member 6	Rattus norvegicus	0-4
11161534-8	2001	Thus, our results suggest that malonate binds to sorbed Pb(II) adions, forming ternary metal-bridging surface complexes.	malonic acid	31-39	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
11161534-3	2001	In the absence of Pb(II), ATR-FTIR measurements of sorbed malonate suggest the formation of more than one malonate surface complex.	malonic acid	58-66	ATR serine/threonine kinase	Homo sapiens	26-29
11161607-0	2001	Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.	malonic acid	122-130	superoxide dismutase 2, mitochondrial	Mus musculus	34-64
11429834-5	2001	On the other hand, the use of palladium complexes with PPh3 as the ligand inhibits the transmetalation pathway and promotes the nucleophilic attack of the malonate-type anions on the intermediate (eta 3-allyl)-palladium complexes.	malonic acid	155-163	caveolin 1	Homo sapiens	55-59
11161607-5	2001	Compared to littermate wild-type mice, mice with partial SOD2 deficiency showed increased vulnerability to dopamine depletion after systemic MPTP treatment and significantly larger striatal lesions produced by both 3-NP and malonate.	malonic acid	224-232	superoxide dismutase 2, mitochondrial	Mus musculus	57-61
11161607-6	2001	SOD2(+/-) mice also showed an increased production of "hydroxyl" radicals after malonate injection measured with the salicylate hydroxyl radical trapping method.	malonic acid	80-88	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
10903889-8	2000	Lastly, in malonate-injured rat brains, the ipsilateral side showed a striking correlation of SBDP formation with p35 to p25 conversion and tau phosphorylation (at Ser202 and Thr205) increase.	malonic acid	11-19	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	114-117
11121487-6	2000	Malonic acid, which decreased the oxidative stress in mitochondria, partially suppressed both petite induction and the temperature-induced increase in the amount of mtDNA damage in mhr1-1 cells at 37 degrees C. Thus, functional mitochondria require active MHR1, which keeps the extent of spontaneous oxidative damage in mtDNA within a tolerable level.	malonic acid	0-12	Mhr1p	Saccharomyces cerevisiae S288C	181-187
11121487-6	2000	Malonic acid, which decreased the oxidative stress in mitochondria, partially suppressed both petite induction and the temperature-induced increase in the amount of mtDNA damage in mhr1-1 cells at 37 degrees C. Thus, functional mitochondria require active MHR1, which keeps the extent of spontaneous oxidative damage in mtDNA within a tolerable level.	malonic acid	0-12	Mhr1p	Saccharomyces cerevisiae S288C	256-260
10899963-0	2000	Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.	malonic acid	0-8	caspase 1	Mus musculus	93-102
10899963-3	2000	Intrastriatal injection of malonate resulted in significantly smaller striatal lesions in mutant caspase-1 mice than those observed in littermate control mice.	malonic acid	27-35	caspase 1	Mus musculus	97-106
10899963-4	2000	Caspase-1 was significantly activated following malonate intrastriatal administration in control mice but significantly attenuated in mutant caspase-1 mice.	malonic acid	48-56	caspase 1	Mus musculus	0-9
10899963-6	2000	These results provide further evidence of a functional role for caspase-1 in both malonate- and 3-NP-mediated neurotoxin models of HD.	malonic acid	82-90	caspase 1	Mus musculus	64-73
10903889-8	2000	Lastly, in malonate-injured rat brains, the ipsilateral side showed a striking correlation of SBDP formation with p35 to p25 conversion and tau phosphorylation (at Ser202 and Thr205) increase.	malonic acid	11-19	lipocalin 2	Rattus norvegicus	121-124
10585886-1	1999	The dicarboxylate carrier (DIC) is a nuclear-encoded protein located in the mitochondrial inner membrane.	malonic acid	4-17	solute carrier family 25 member 10	Homo sapiens	27-30
10773757-5	2000	We recently reported that CMPF and BR share the binding site for dicarboxylate molecules on the HSA molecule [Pharm Res 1999;16:916-923].	malonic acid	65-78	albumin	Homo sapiens	96-99
10627575-0	2000	Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.	malonic acid	82-90	glutathione peroxidase 1	Mus musculus	18-49
10207168-7	1999	In situ hybridization revealed that SDCT2 is prominently expressed in kidney proximal tubule S3 segments and in perivenous hepatocytes, consistent with the sites of high-affinity dicarboxylate transport identified based on vesicle studies.	malonic acid	179-192	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 L homeolog	Xenopus laevis	36-41
10397614-0	1999	Interaction between two dicarboxylate endogenous substances, bilirubin and an uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, on human serum albumin.	malonic acid	24-37	albumin	Homo sapiens	152-165
10397614-1	1999	PURPOSE: Two dicarboxylate endogenous substances, bilirubin (BR) and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), have a very high affinity to human serum albumin (HSA).	malonic acid	13-26	albumin	Homo sapiens	162-175
10022228-5	1998	On the other hand, we recently isolated a complementary DNA that encodes an organic anion transporter 1 (OAT1) as an anion/dicarboxylate exchanger of the basolateral membrane of proximal tubule.	malonic acid	123-136	solute carrier family 22 member 6	Homo sapiens	76-103
9920886-6	1999	NaDC3 accepts a number of dicarboxylates including dimethylsuccinate as substrates and excludes monocarboxylates.	malonic acid	26-40	solute carrier family 13 member 3	Homo sapiens	0-5
10022228-5	1998	On the other hand, we recently isolated a complementary DNA that encodes an organic anion transporter 1 (OAT1) as an anion/dicarboxylate exchanger of the basolateral membrane of proximal tubule.	malonic acid	123-136	solute carrier family 22 member 6	Homo sapiens	105-109
9464365-0	1998	Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8).	malonic acid	24-36	matrix metallopeptidase 8	Homo sapiens	63-85
10203688-2	1998	Intrastriatal injections of malonate induced cleavage of caspase-2 beginning at 6 h, and caspase-3-like activity as identified by DEVD biotin affinity-labeling within 12 h. DEVD affinity-labeling was prevented and lesion volume reduced in transgenic mice overexpressing BCL-2 in neuronal cells.	malonic acid	28-36	caspase 2	Rattus norvegicus	57-66
10203688-2	1998	Intrastriatal injections of malonate induced cleavage of caspase-2 beginning at 6 h, and caspase-3-like activity as identified by DEVD biotin affinity-labeling within 12 h. DEVD affinity-labeling was prevented and lesion volume reduced in transgenic mice overexpressing BCL-2 in neuronal cells.	malonic acid	28-36	caspase-3-like	Rattus norvegicus	89-103
10203688-2	1998	Intrastriatal injections of malonate induced cleavage of caspase-2 beginning at 6 h, and caspase-3-like activity as identified by DEVD biotin affinity-labeling within 12 h. DEVD affinity-labeling was prevented and lesion volume reduced in transgenic mice overexpressing BCL-2 in neuronal cells.	malonic acid	28-36	B cell leukemia/lymphoma 2	Mus musculus	270-275
9668069-12	1998	However, NaDC-1 contains a single high affinity binding site for Li+ that, when occupied, results in transport inhibition, which may account for its potent inhibitory effects on renal dicarboxylate transport.	malonic acid	184-197	solute carrier family 13 member 2L homeolog	Xenopus laevis	9-15
9614221-5	1998	PC12 cell lines expressing a PS-1 mutation (L286V) exhibited increased sensitivity to apoptosis induced by 3-nitropropionic acid (3-NP) and malonate, inhibitors of succinate dehydrogenase, compared with control cell lines and lines overexpressing wild-type PS-1.	malonic acid	140-148	presenilin 1	Rattus norvegicus	29-33
9464365-0	1998	Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8).	malonic acid	24-36	matrix metallopeptidase 8	Homo sapiens	87-91
9048766-2	1997	In the present study, unilateral focal infusions of malonate into the nucleus basalis magnocellularis (nbM) of male Sprague-Dawley rats (weighing 250-300 g) resulted in a dose-related depletion in ipsilateral cortical and amygdaloid choline acetyltransferase (ChAT) activity.	malonic acid	52-60	choline O-acetyltransferase	Rattus norvegicus	233-258
9228014-5	1997	The uptake rate of PAH was increased by the outwardly directed dicarboxylate gradient, consisting with the idea that OAT1 is an organic anion/dicarboxylate exchanger.	malonic acid	63-76	solute carrier family 22 member 6	Rattus norvegicus	117-121
9185322-5	1997	The stimulatory effects of 4-PA, maleate and Cd2+ on the fluorescein uptake were markedly attenuated by LiCl (5 mM), suggesting that the Na-coupled re-uptake of alpha-ketoglutarate is involved in energization of the fluorescein uptake in the exchange for the cytoplasmic dicarboxylate.	malonic acid	271-284	Cd2 molecule	Rattus norvegicus	45-48
9083004-2	1997	This activity, monitored by the formation of Mn(III)-malate or -malonate, is inhibited by Co(II) but not by superoxide dismutase.	malonic acid	63-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
9409726-2	1997	Infusion of 2 micromol malonate into the left striatum of rats resulted in a 67% loss of striatal DA and a 40% loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra.	malonic acid	23-31	tyrosine hydroxylase	Rattus norvegicus	119-139
9409726-2	1997	Infusion of 2 micromol malonate into the left striatum of rats resulted in a 67% loss of striatal DA and a 40% loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra.	malonic acid	23-31	tyrosine hydroxylase	Rattus norvegicus	141-143
8592116-5	1996	Malonate produced a dose-dependent lesion in which CA1 pyramidal neurons were most vulnerable, followed by CA3 and dentate gyrus.	malonic acid	0-8	carbonic anhydrase 1	Rattus norvegicus	51-54
9056390-0	1997	S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity.	malonic acid	85-93	nitric oxide synthase 2	Homo sapiens	35-56
9056390-2	1997	In the present experiments we found that S-methylthiocitrulline, a relatively selective neuronal nitric oxide synthase (NOS) inhibitor, produced significant neuroprotection against striatal lesions produced by malonate, and the protection was reversed by l-arginine but not by d-arginine.	malonic acid	210-218	nitric oxide synthase 2	Homo sapiens	97-118
8978755-4	1997	In contrast, transgenic mice overexpressing glutathione peroxidase (hGPE) that received an intrastriatal infusion of malonate (3 mumol) into the left side had significantly less loss of striatal dopamine than their hGPE-negative littermates when assayed 1 week following infusion.	malonic acid	117-125	glycophorin E (MNS blood group)	Homo sapiens	68-72
8978755-4	1997	In contrast, transgenic mice overexpressing glutathione peroxidase (hGPE) that received an intrastriatal infusion of malonate (3 mumol) into the left side had significantly less loss of striatal dopamine than their hGPE-negative littermates when assayed 1 week following infusion.	malonic acid	117-125	glycophorin E (MNS blood group)	Homo sapiens	215-219
8810298-10	1996	Finally, we present evidence that of all the dicarboxylates tested only DC2-DC4 can be transported by the classical dicarboxylate carrier.	malonic acid	45-59	monoacylglycerol O-acyltransferase 1	Homo sapiens	72-75
8810298-10	1996	Finally, we present evidence that of all the dicarboxylates tested only DC2-DC4 can be transported by the classical dicarboxylate carrier.	malonic acid	45-58	monoacylglycerol O-acyltransferase 1	Homo sapiens	72-75
8667023-0	1996	Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.	malonic acid	9-17	nitric oxide synthase 1, neuronal	Mus musculus	44-74
8667023-4	1996	Malonate striatal lesions were significantly attenuated in the nNOS mutant mice, and they were significantly increased in the eNOS mutant mice.	malonic acid	0-8	nitric oxide synthase 1, neuronal	Mus musculus	63-67
8667023-5	1996	Malonate-induced increases in levels of 2,3- and 2,5-dihydroxybenzoic acid/salicylate, markers of hydroxyl radical generation, were significantly attenuated in the nNOS knockout mice.	malonic acid	0-8	nitric oxide synthase 1, neuronal	Mus musculus	164-168
8667023-6	1996	Malonate-induced increases in 3-nitrotyrosine, a marker for peroxynitrite-mediated damage, were blocked in the nNOS mice, whereas a significant increase occurred in the eNOS mice.	malonic acid	0-8	nitric oxide synthase 1, neuronal	Mus musculus	111-115
8667023-8	1996	produced by nNOS results in generation of peroxynitrite, which plays a role in malonate neurotoxicity.	malonic acid	79-87	nitric oxide synthase 1, neuronal	Mus musculus	12-16
8871943-3	1996	Intrahippocampal injection of 3-nitropropionic acid (3-NP) and malonic acid resulted in neuronal death, particularly in CA1.	malonic acid	63-75	carbonic anhydrase 1	Homo sapiens	120-123
7790410-3	1995	In the present study, we examined whether systemically administered bFGF could prevent neuronal death induced by intrastriatal injection of N-methyl-D-aspartate (NMDA) or chemical hypoxia induced by intrastriatal injection of malonate in adult rats and 1-methyl-4-phenylpyridinium (MPP+) in neonatal rats.	malonic acid	226-234	fibroblast growth factor 2	Rattus norvegicus	68-72
7556544-0	1995	Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum.	malonic acid	26-38	calbindin 1	Rattus norvegicus	103-112
8750236-8	1995	Transport assays revealed that the mae1 gene encodes a permease involved in the uptake of L-malate, succinate and malonic acid.	malonic acid	114-126	malate dehydrogenase (oxaloacetate-decarboxylating)	Saccharomyces cerevisiae S288C	35-39
7578099-1	1995	The binding of the two synergistic anion mimics, phosphate and sulfate, and of the synergistic anions, malonate and oxalate, to the N-lobe of recombinant human serum transferrin (hTF/2N) wild-type and H207E mutant protein was assessed by difference ultraviolet (UV) spectroscopy at 246 nm as a function of pH.	malonic acid	103-111	transferrin	Homo sapiens	166-177
7790410-4	1995	Systemic administration of bFGF (100 micrograms/kg) for three doses both before and after intrastriatal injection of either NMDA or malonate in adult rats produced a significant neuroprotective effect.	malonic acid	132-140	fibroblast growth factor 2	Rattus norvegicus	27-31
8305846-3	1993	There is a partially overlapping substrate specificity between the PAH, dicarboxylate, and sulfate transport systems but also between the PAH and organic cation transport system.	malonic acid	72-85	phenylalanine hydroxylase	Homo sapiens	138-141
7813471-7	1994	This was achieved by measuring the effects of KCN (or malonate or N,N,N",N"-tetramethyl-p-phenylenediamine) on system flux when intermediates were allowed to relax and on local flux when intermediates were held constant.	malonic acid	54-62	neurogenin 3	Rattus norvegicus	158-163
7783143-3	1995	In vitro evaluation against human bronchiolar ECE revealed that in all cases hydroxamates derived from malonate were more potent than hydroxamates derived from succinate.	malonic acid	103-111	endothelin converting enzyme 1	Homo sapiens	46-49
7675303-0	1995	Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid.	malonic acid	96-108	carbonic anhydrase 1	Homo sapiens	31-34
7675303-3	1995	The CA1 region was exquisitely sensitive to malonate and the dentate gyrus was extremely resistant; the CA3 region had intermediate sensitivity.	malonic acid	44-52	carbonic anhydrase 1	Homo sapiens	4-7
7840619-4	1995	Substrate protection studies demonstrated that substrates for the tricarboxylate transporter (i.e., citrate, isocitrate, phosphoenolpyruvate, and malate) effectively protected against PLP inhibition, whereas other organic anions which are not transported by the tricarboxylate carrier (i.e., malonate, alpha-ketoglutarate, phosphate, and succinate) afforded considerably less protection.	malonic acid	292-300	pyridoxal phosphatase	Homo sapiens	184-187
1458159-2	1992	It is suggested that malonic acid derivatives may influence the antioxidizing enzymes--catalase, glucose-6-phosphate dehydrogenase and superoxide dismutase.	malonic acid	21-33	glucose-6-phosphate dehydrogenase	Homo sapiens	97-130
8243798-6	1993	Reactions at P450scc and P45011 beta, mediated by IC, are enhanced by low concentrations of various dicarboxylates anions (fumarate, SU).	malonic acid	100-114	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	13-20
8500224-8	1993	Against the A2780 tumor, the Pt(IV) dicarboxylates produced individual best effects of between 0.8-1.1 LCK, based on data from two or three experiments.	malonic acid	36-50	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	103-106
7689641-1	1993	Intrastriatal injection of malonate, a reversible inhibitor of succinate dehydrogenase (SDH), produced age-dependent striatal lesions, which were significantly greater in 4- and 12-month-old animals than in 1-month-old animals.	malonic acid	27-35	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	63-86
7689641-1	1993	Intrastriatal injection of malonate, a reversible inhibitor of succinate dehydrogenase (SDH), produced age-dependent striatal lesions, which were significantly greater in 4- and 12-month-old animals than in 1-month-old animals.	malonic acid	27-35	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	88-91
7689641-7	1993	These results show that the competitive SDH inhibitor malonate produces more transient and milder bioenergetic defects than 3-NP, which are associated with selective activation of NMDA receptors.	malonic acid	54-62	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	40-43
1518531-8	1992	Malonate blocked not only succinate-cytochrome c reductase and fumarate reductase, but also intact cell motility.	malonic acid	0-8	cytochrome c, somatic	Homo sapiens	36-48
2357226-4	1990	The substrate requirements of E1 and E2 were highly specific for malonate and malonamate, respectively.	malonic acid	65-73	transcription factor E1	Glycine max	30-39
2276278-8	1990	Malonate (5 mM) rapidly reversed a 5 mM succinate-induced hyperpolarization of PDI which also suggests a metabolically mediated effect on PDI.	malonic acid	0-8	protein disulfide-isomerase	Oryctolagus cuniculus	79-82
2276278-8	1990	Malonate (5 mM) rapidly reversed a 5 mM succinate-induced hyperpolarization of PDI which also suggests a metabolically mediated effect on PDI.	malonic acid	0-8	protein disulfide-isomerase	Oryctolagus cuniculus	138-141
1646634-5	1991	(3) With the ATPase as H(+)-consuming pump, at equivalent delta mu H+ values, the output flow is more markedly inhibited by malonate than by uncouplers; the latter, however, are more inhibitory than lipophilic anions such as ClO4-.	malonic acid	124-132	dynein axonemal heavy chain 8	Homo sapiens	13-19
2384742-5	1990	The dry weight yield of cells from malonate was estimated at 2.5 g mol-1.	malonic acid	35-43	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	67-72
34821502-1	2021	The complexation of Np(V) with malonate and succinate is studied by different spectroscopic techniques, namely, attenuated total reflection Fourier transform infrared (ATR FT-IR) and extended X-ray absorption fine-structure (EXAFS) spectroscopy, as well as by quantum chemistry to determine the speciation, thermodynamic data, and structural information of the formed complexes.	malonic acid	31-39	ATR serine/threonine kinase	Homo sapiens	168-171
12177002-9	2002	NaCT represents the first transporter to be identified in mammalian cells that shows preference for citrate over dicarboxylates.	malonic acid	113-127	solute carrier family 13 member 2	Homo sapiens	0-4
34821502-3	2021	The complexation reactions are investigated as a function of the total concentration of malonate ((Mal2-)total) and succinate ((Succ2-)total), ionic strength (Im = 0.5-4.0 mol kg-1 Na+(Cl-/ClO4-)), and temperature (Theta = 20-85  C).	malonic acid	88-96	mal, T cell differentiation protein 2	Homo sapiens	99-103
34821502-11	2021	In addition to the thermodynamic data, the structures of the complexes and the coordination modes of malonate and succinate are investigated using EXAFS spectroscopy, ATR-FT-IR spectroscopy, and quantum chemical calculations.	malonic acid	101-109	ATR serine/threonine kinase	Homo sapiens	167-170
34102574-4	2021	Mitochondria do not produce GSH, and although the transport of GSH to mitochondria is not fully understood, two carrier proteins, the dicarboxylate carrier (DIC, SLC25A10) and the oxoglutarate carrier (OGC, SLC25A11) have been suggested to participate in GSH transport.	malonic acid	134-147	solute carrier family 25 member 10	Homo sapiens	162-170
34623563-9	2022	Significantly, malonate and vigabatrin blocked the effects of the GABA shunt in the HK activity coupled to OXPHOS.	malonic acid	15-23	hexokinase 1	Homo sapiens	84-86
34677384-6	2021	Though both Drosophila INDY and mammalian INDY transport citrate, the translocation mechanism differs, the former being a dicarboxylate exchanger for the influx of citrate2- in exchange for other dicarboxylates, and the latter being a Na+-coupled uniporter for citrate2-.	malonic acid	122-135	I'm not dead yet	Drosophila melanogaster	23-27
34677384-6	2021	Though both Drosophila INDY and mammalian INDY transport citrate, the translocation mechanism differs, the former being a dicarboxylate exchanger for the influx of citrate2- in exchange for other dicarboxylates, and the latter being a Na+-coupled uniporter for citrate2-.	malonic acid	122-135	I'm not dead yet	Drosophila melanogaster	42-46
34234892-6	2021	As a result, we demonstrated that malonic acid on LPS-treated microglia decreased pro-inflammatory responses and mechanisms of the p38 MAPK/NF-kappaB pathway.	malonic acid	34-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
34328001-3	2021	Herein, inspired by a recent unveiled structure of Zn6(H2O)3(BTP)4 and by means of an amide-functionalized preliminary single tricarboxylate, a subsequent mixed tricarboxylate, and dicarboxylate linkers, an intricate three-way rod MOF and the next three isoreticular three-way rod MOFs have been successfully realized, namely, 3W-ROD-1 and 3W-ROD-2-X (X = -OH, -F, and -CH3), respectively.	malonic acid	181-194	polypyrimidine tract binding protein 3	Homo sapiens	330-342
35486485-8	2022	Interestingly, with a subtle change from adc in CP1 to fumarate in CP2 as the dicarboxylate linker, the latter performed much better than the former and displayed an excellent electrochemical stability in basic medium.	malonic acid	78-91	ceruloplasmin	Homo sapiens	67-70
34234892-0	2021	Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-kappaB pathway.	malonic acid	0-12	mitogen-activated protein kinase 14	Mus musculus	99-107
34234892-0	2021	Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-kappaB pathway.	malonic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-117
34234892-6	2021	As a result, we demonstrated that malonic acid on LPS-treated microglia decreased pro-inflammatory responses and mechanisms of the p38 MAPK/NF-kappaB pathway.	malonic acid	34-46	mitogen-activated protein kinase 14	Mus musculus	131-139
35410329-2	2022	In a "closed" hSR structure containing the allosteric activator ATP, the inhibitor malonate is enclosed between the large and small domains while ATP is distal to the active site, residing at the dimer interface with the Tyr121 hydroxyl group contacting the alpha-phosphate of ATP.	malonic acid	83-91	HSR	Homo sapiens	14-17
35255883-4	2022	Deep-Eutectic Solvents composed of choline chloride and malonic acid had the best extraction efficiency, with the optimal extraction conditions being as follows: a solid-liquid ratio of 40 mg/mL, an extraction temperature of 55  C, an extraction time of 70 min and a DES with 20% water content.	malonic acid	56-68	thrombopoietin	Mus musculus	192-194
34935828-3	2022	The parent heterocycles HL1 and HL2 both generate robust and permanently porous isomeric MOFs on reaction with zinc and a dicarboxylate co-ligand.	malonic acid	122-135	asialoglycoprotein receptor 1	Homo sapiens	24-27
34935828-3	2022	The parent heterocycles HL1 and HL2 both generate robust and permanently porous isomeric MOFs on reaction with zinc and a dicarboxylate co-ligand.	malonic acid	122-135	intelectin 2	Homo sapiens	32-35
35036692-3	2022	The structure is a binary complex of MDH1 with only a bound malonate molecule in the substrate binding site.	malonic acid	60-68	malate dehydrogenase 1	Homo sapiens	37-41
35071379-1	2021	Acyl-CoA synthetase family member 3 (ACSF3) carries out the first step of mitochondrial fatty acid synthesis II, which is the linkage of malonate and, to a lesser extent, methylmalonate onto CoA.	malonic acid	137-145	acyl-CoA synthetase family member 3	Bos taurus	0-35
35071379-1	2021	Acyl-CoA synthetase family member 3 (ACSF3) carries out the first step of mitochondrial fatty acid synthesis II, which is the linkage of malonate and, to a lesser extent, methylmalonate onto CoA.	malonic acid	137-145	acyl-CoA synthetase family member 3	Bos taurus	37-42
3994742-10	1985	An inhibitor of catalase activity, malonate, decreased the rate of cyanamide inactivation of ALDH in intact mitochondria.	malonic acid	35-43	catalase	Rattus norvegicus	16-24
4008496-0	1985	Inhibition of lipid synthesis by beta beta"-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in the rat in vivo.	malonic acid	78-109	anti-Mullerian hormone receptor type 2	Rattus norvegicus	69-72
3395646-4	1988	The malate dehydrogenase activity is fully inhibited by the inhibitors of the dicarboxylate-binding site of the enzyme, i.e., N-ethylmaleimide and malonate and is practically insensitive to carboxin, a specific inhibitor of the ubiquinone-binding center.	malonic acid	78-91	malic enzyme 1	Homo sapiens	4-24
3395646-4	1988	The malate dehydrogenase activity is fully inhibited by the inhibitors of the dicarboxylate-binding site of the enzyme, i.e., N-ethylmaleimide and malonate and is practically insensitive to carboxin, a specific inhibitor of the ubiquinone-binding center.	malonic acid	147-155	malic enzyme 1	Homo sapiens	4-24
3019394-4	1986	Using the correct wavelength pair, and with malonate to slow down the electron input, the reduction course of cytochrome b was still triphasic but a plateau or a turn replaced the oxidation phase previously reported by several authors.	malonic acid	44-52	mitochondrially encoded cytochrome b	Homo sapiens	110-122
3994742-10	1985	An inhibitor of catalase activity, malonate, decreased the rate of cyanamide inactivation of ALDH in intact mitochondria.	malonic acid	35-43	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	93-97
6435698-9	1984	(4) Addition of malonic acid as a buffer for Mg2+ largely eliminated this problem.	malonic acid	16-28	mucin 7, secreted	Homo sapiens	45-48
7161187-5	1982	One of the hydroxyl groups (presumably at C-19) forms a hemiketal ring with the keto group at C-15, and another (at either C-21 or C-23) forms a hemiester with a malonic acid moiety.	malonic acid	162-174	TBL1X/Y related 1	Homo sapiens	123-127
6705144-5	1984	A study on the pH dependence using 100 mM malonate buffer, pH 2.0-6.0, revealed a maximum rate at pH 3.5, with steep slopes above and below this pH value, in agreement with a mathematical analysis of the reaction equations.	malonic acid	42-50	polyhomeotic homolog 2	Homo sapiens	59-63
7161187-5	1982	One of the hydroxyl groups (presumably at C-19) forms a hemiketal ring with the keto group at C-15, and another (at either C-21 or C-23) forms a hemiester with a malonic acid moiety.	malonic acid	162-174	nucleolin	Homo sapiens	131-135
6127053-3	1982	Saturation constants (Ks) of P17 with acetate, arginine, aspartate, glutamate, lactate, succinate, malonate, p-hydroxybenzoate and glucose were all below 1 microM.	malonic acid	99-107	family with sequence similarity 72 member B	Homo sapiens	29-32
6954519-6	1982	It is shown that inhibitors such as 2,4-dinitrophenol and malonate exert only slight inhibition of the pentose shunt yet release the glucose-mediated curb elicited by glucose and glucosamine in the parental PGI+ strain and also the glucose transport curb persisting in the PGI mutant.	malonic acid	58-66	glucose-6-phosphate isomerase	Cricetulus griseus	207-210
6954519-6	1982	It is shown that inhibitors such as 2,4-dinitrophenol and malonate exert only slight inhibition of the pentose shunt yet release the glucose-mediated curb elicited by glucose and glucosamine in the parental PGI+ strain and also the glucose transport curb persisting in the PGI mutant.	malonic acid	58-66	glucose-6-phosphate isomerase	Cricetulus griseus	273-276
454714-10	1979	A possible role of malonyl-CoA decarboxylase as an enzyme which protects the cell against accumulation of malonyl-CoA and its immediate metabolites -- malonate and methylmalonyl-CoA is disucssed.	malonic acid	151-159	malonyl-CoA decarboxylase	Rattus norvegicus	19-44
6786338-5	1981	The pH dependence of terephthalate binding as well as the spectral similarities of the dicarboxylate complexes to the ESO2 intermediate provides further evidence for the suggestion that this intermediate is a tightly bound enzyme-product complex.	malonic acid	87-100	cancer/testis antigen 2	Homo sapiens	118-122
4465902-0	1974	The effect of malonate on succinic dehydrogenase (SDH) activity during the multiplication of influenza and herpes viruses in the embryonate hen egg.	malonic acid	14-22	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	26-48
1175635-10	1975	It is inferred that alipathic and aromatic dicarboxylates bind at different subsites in the active site region, perturbing the coenzyme pKa by an indirect protein-mediated mechanism.	malonic acid	43-57	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	136-139
4465902-0	1974	The effect of malonate on succinic dehydrogenase (SDH) activity during the multiplication of influenza and herpes viruses in the embryonate hen egg.	malonic acid	14-22	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	50-53
16657283-7	1970	Malonate inhibits the initial decrease and the subsequent increase in reducing sugars in control buds, but not the increase induced by GA(3).Total protein in buds was not influenced by 10(-4)m GA(3) over a period of 40 hours, nor did activity of alpha-amylase increase significantly until 20 hours after beginning of treatment.	malonic acid	0-8	alpha-amylase	Solanum tuberosum	246-259
16655852-0	1963	Malonic Acid Biosynthesis in Bush Bean Roots.	malonic acid	0-12	brain expressed associated with NEDD4 1	Homo sapiens	34-38
16655853-0	1963	Malonic Acid Biosynthesis in Bush Bean Roots.	malonic acid	0-12	brain expressed associated with NEDD4 1	Homo sapiens	34-38
13042804-2	1953	Metabolism of acetate-1-C14 in malonate-treated rats.	malonic acid	31-39	anti-Mullerian hormone receptor type 2	Rattus norvegicus	24-27
16655192-0	1959	Malonate as a Participant in Organic Acid Metabolism in Bush Bean Leaves.	malonic acid	0-8	brain expressed associated with NEDD4 1	Homo sapiens	61-65
14821851-0	1951	C13 isotope effect in the decarboxylation of normal malonic acid.	malonic acid	52-64	homeobox C13	Homo sapiens	0-3
33666092-9	2021	Our evidence also shows that inhibition of SDH by malonate treatment after birth extends the window of cardiomyocyte proliferation and regeneration in juvenile mice.	malonic acid	50-58	aminoadipate-semialdehyde synthase	Mus musculus	43-46
33666092-11	2021	Our metabolite analysis following SDH inhibition by malonate induces dynamic changes in adult cardiac metabolism.	malonic acid	52-60	aminoadipate-semialdehyde synthase	Mus musculus	34-37
33666092-12	2021	Conclusions: Inhibition of SDH by malonate promotes adult cardiomyocyte proliferation, revascularization, and heart regeneration via metabolic reprogramming.	malonic acid	34-42	aminoadipate-semialdehyde synthase	Mus musculus	27-30
33751015-8	2021	Besides, the enhancement effect of ASP is compared with that of malonic acid (MOA) with two carboxylic acid groups (Chemosphere, 2018, 203, 26-33), and ASP presents a more obvious enhancement effect than MOA.	malonic acid	64-76	assembly factor for spindle microtubules	Homo sapiens	152-155
33744860-3	2021	Ether lipid metabolism, glycerolipid metabolism, and glyoxylate and dicarboxylate metabolism were differentially enriched between the Rb1 and model groups.	malonic acid	68-81	RB transcriptional corepressor 1	Mus musculus	134-137
33923786-1	2021	Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients.	malonic acid	46-54	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
33923786-1	2021	Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients.	malonic acid	46-54	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
33342207-0	2021	NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines.	malonic acid	58-70	nibrin	Homo sapiens	0-3
33546743-7	2021	Through integrated data analysis, we obtained five significant p53-dependent metabolic pathways including phenylalanine, glyoxylate, dicarboxylate, and linoleic acid metabolism, and the citrate cycle.	malonic acid	133-146	tumor protein p53	Homo sapiens	63-66
33435514-3	2021	Herein, we report the synthesis and evaluation of a family of malonate-based modified nucleosides to investigate the optimal positioning of metal-binding groups in nucleoside-derived inhibitors for SNM1A.	malonic acid	62-70	DNA cross-link repair 1A	Homo sapiens	198-203
33080510-1	2021	The paper explains the relationship between the energy of hydrogen bonds and the distance between associated carboxyl groups of malonic acid (MA) molecules by means of infrared spectroscopic studies of crystals of its four isotopic varieties [CH2(COOH)2, h4-MA; CH2(COOD)2, d2c-MA; CD2(COOH)2, d2m-MA; CD2(COOD)2, d4-MA].	malonic acid	128-140	CD2 molecule	Homo sapiens	282-285
33080510-1	2021	The paper explains the relationship between the energy of hydrogen bonds and the distance between associated carboxyl groups of malonic acid (MA) molecules by means of infrared spectroscopic studies of crystals of its four isotopic varieties [CH2(COOH)2, h4-MA; CH2(COOD)2, d2c-MA; CD2(COOH)2, d2m-MA; CD2(COOD)2, d4-MA].	malonic acid	128-140	CD2 molecule	Homo sapiens	302-305
33342207-1	2021	A general DBU-mediated one-pot three-component cycloaddition reaction of easily accessible malonic acid derivatives, nitrosoarenes, and alkenes has been successfully established with the aid of NBS to provide direct access to highly functionalized isoxazolidine derivatives with generally good to excellent yields, broad functional group tolerance, and excellent regio- and diastereo-selectivities under mild conditions.	malonic acid	91-103	nibrin	Homo sapiens	194-197
33342207-2	2021	The mechanism study shows that the NBS-mediated formation of bromomalonic acid derivatives from malonic acid derivatives and DBU-promoted synthesis of nitrone intermediates via the reaction of bromomalonic acid derivatives with nitrosoarenes are key steps.	malonic acid	66-78	nibrin	Homo sapiens	35-38
33180421-18	2020	GSEA showed that genes in high expression group of SLC19A1 were enriched in KEGG pathways, including "Glyoxylate and dicarboxylate metabolism", "Oxidative phosphorylation", "Aminoacyl tRNA biosynthesis", "Base excision repair", "Pyrimidine metabolism" and "Proteasome".	malonic acid	117-130	solute carrier family 19 member 1	Homo sapiens	51-58
32940784-12	2020	nNOS-derived NO was partially reduced by malonate + PA.	malonic acid	41-49	nitric oxide synthase 1	Rattus norvegicus	0-4
33014287-7	2020	The glycolytic pathway in caspase-4 positive NSCLC tissues was bypassed by the malonic acid-dependent lipogenesis.	malonic acid	79-91	caspase 4	Homo sapiens	26-35
32999308-9	2020	Fecal and serum metabolic profile showed that malonate which influences the immune system was significantly more abundant in DJ-1-/- mice.	malonic acid	46-54	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	125-129
32333952-10	2020	The combination of network pharmacology, metabolomics, western blot, and PCR showed that HLD can treat T2DM by enhancing the gene and protein expression levels of glucose transporter 4 (GLUT4), insulin receptor (INSR), and mitogen-activated protein kinase 1 (MAPK1) to interfere with glyoxylate and dicarboxylate metabolism.	malonic acid	299-312	solute carrier family 2 member 4	Rattus norvegicus	163-184
32840539-0	2020	Effecting structural diversity in a series of Co(II)-organic frameworks by the interplay between rigidity of a dicarboxylate and flexibility of bis(tridentate) spanning ligands.	malonic acid	111-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
32876527-2	2020	It has been shown that mitochondrial metabolites, transported by the citrate carrier (CIC), dicarboxylate carrier (DIC), oxoglutarate carrier (OGC), and mitochondrial pyruvate carrier (MPC) play a vital role in the regulation of glucose-stimulated insulin secretion (GSIS).	malonic acid	92-105	insulin	Homo sapiens	248-255
32887801-6	2020	Importantly, we also identify a small molecule dicarboxylate that acts as an essential cofactor in this process and works in synergy with SDHAF2 to properly orient the flavin and capping domains of SDHA.	malonic acid	47-60	succinate dehydrogenase complex assembly factor 2	Homo sapiens	138-144
32887801-6	2020	Importantly, we also identify a small molecule dicarboxylate that acts as an essential cofactor in this process and works in synergy with SDHAF2 to properly orient the flavin and capping domains of SDHA.	malonic acid	47-60	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	138-142
32863205-4	2020	Among these, the competitive SDH inhibitor malonate, administered as a cell-permeable malonate ester prodrug, has shown promise in models of cardiac IR injury, but the efficacy of malonate ester prodrugs against renal IR injury have not been investigated.	malonic acid	43-51	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	29-32
32333952-10	2020	The combination of network pharmacology, metabolomics, western blot, and PCR showed that HLD can treat T2DM by enhancing the gene and protein expression levels of glucose transporter 4 (GLUT4), insulin receptor (INSR), and mitogen-activated protein kinase 1 (MAPK1) to interfere with glyoxylate and dicarboxylate metabolism.	malonic acid	299-312	solute carrier family 2 member 4	Rattus norvegicus	186-191
32234596-9	2020	Cecum contents metabolomics revealed that 16 biomarkers associated with PBR antidepressant effect were screened, which were involved 3 metabolic pathways including primary bile acid biosynthesis, taurine and hypotaurine metabolism, glyoxylate and dicarboxylate metabolism.	malonic acid	247-260	translocator protein	Rattus norvegicus	72-75
32648168-3	2022	Inhibition of succinate accumulation and/or oxidation by dimethyl malonate (DMM), a cell permeable prodrug of the SDH inhibitor malonate, can decrease I/R injury.	malonic acid	66-74	aminoadipate-semialdehyde synthase	Mus musculus	114-117
32648168-8	2022	RESULTS: We found that the diacetoxymethyl malonate diester (MAM) most rapidly delivered large amounts of malonate to cells in vivo.	malonic acid	43-51	PZP, alpha-2-macroglobulin like	Mus musculus	61-64
32648168-10	2022	CONCLUSIONS: The rapidly hydrolysed malonate prodrug MAM can protect against cardiac I/R injury in a clinically relevant mouse model.	malonic acid	36-44	PZP, alpha-2-macroglobulin like	Mus musculus	53-56
31172995-4	2019	The results with the monomer of hAOX1 allowed to shed some light on the role played by thioridazine and two malonate ions that are co-crystalized in the recent X-ray structure of hAOX1.	malonic acid	108-116	aldehyde oxidase 1	Homo sapiens	32-37
31947805-0	2020	A Pair of CoII Supramolecular Isomers Based on Flexible Bis-Pyridyl-Bis-Amide and Angular Dicarboxylate Ligands.	malonic acid	90-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
31789022-0	2019	AAAA-DDDD Quadruple H-Bond-Assisted Ionic Interactions: Robust Bis(guanidinium)/Dicarboxylate Heteroduplexes in Water.	malonic acid	80-93	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	5-9
31402355-3	2019	To promote the antitumor efficacy of chemical drugs by suppressing hypoxia, we designed and conjugated a hydrophobic HIF-1alpha inhibitor (YC-1) to a hydrophilic anticancer drug, irinotecan (Ir), into one molecular entity via dicarboxylate and PEG3 linkages.	malonic acid	226-239	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
31356773-4	2019	Their transport properties and kinetic parameters demonstrate that UCP5 and UCP6 transport inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and (only UCP5) glutamate and tricarboxylates.	malonic acid	213-221	solute carrier family 25 member 14	Homo sapiens	67-71
31319025-5	2019	Malonic acid-decorated fullerene (MA-C60) was used as a superoxide disproportionation chemocatalyst mimicking the function of SOD.	malonic acid	0-12	superoxide dismutase 1	Homo sapiens	126-129
31172995-4	2019	The results with the monomer of hAOX1 allowed to shed some light on the role played by thioridazine and two malonate ions that are co-crystalized in the recent X-ray structure of hAOX1.	malonic acid	108-116	aldehyde oxidase 1	Homo sapiens	179-184
30707752-1	2019	Purpose: To characterize two mitochondrial membrane transporters 2-oxoglutarate (OGC) and dicarboxylate (DIC) in human RPE (hRPE) and to elucidate their role in the regulation of mitochondrial glutathione (mGSH) uptake and cell death in oxidative stress.	malonic acid	90-103	ribulose-5-phosphate-3-epimerase	Homo sapiens	124-128
31164982-7	2019	Studies in cultured cells revealed that EMT was induced by SDH inhibition through SDHC CRISPR/Cas9 knockdown or by the enzymatic inhibitor malonate.	malonic acid	139-147	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	59-62
30707752-1	2019	Purpose: To characterize two mitochondrial membrane transporters 2-oxoglutarate (OGC) and dicarboxylate (DIC) in human RPE (hRPE) and to elucidate their role in the regulation of mitochondrial glutathione (mGSH) uptake and cell death in oxidative stress.	malonic acid	90-103	ribulose-5-phosphate-3-epimerase	Homo sapiens	119-122
31066429-6	2019	The same coordination mode of L1 and L2 in complexes 6-8 joins adjacent Cd(ii) cations together with aromatic dicarboxylates, leading to different (63)(65 8), 2-periodic (6 3) and (4 4) layer motifs.	malonic acid	110-124	L1 cell adhesion molecule	Homo sapiens	30-39
31052601-0	2019	Temperature-Controlled Assembly/Reassembly of Two Dicarboxylate-Based Three-Dimensional Co(II) Coordination Polymers with an Antiferromagnetic Metallic Layer and a Ferromagnetic Metallic Chain.	malonic acid	50-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
30225479-0	2018	Cobalt complexes of the chelating dicarboxylate ligand "esp": a paddlewheel-type dimer and a heptanuclear coordination cluster.	malonic acid	34-47	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	56-59
30669552-2	2019	DASS proteins typically mediate the coupled uptake of Na+ ions and dicarboxylate, tricarboxylate, or sulfate.	malonic acid	67-80	latent transforming growth factor beta binding protein 3	Homo sapiens	0-4
30201289-3	2019	While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-CoA synthetase ACSF3.	malonic acid	204-212	acyl-CoA synthetase family member 3	Homo sapiens	234-256
30201289-3	2019	While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-CoA synthetase ACSF3.	malonic acid	204-212	acyl-CoA synthetase family member 3	Homo sapiens	257-262
30201289-5	2019	A major role for ACSF3 is to provide a metabolic pathway for the clearance of malonate by the generation of malonyl-CoA, which can then be decarboxylated to acetyl-CoA by malonyl-CoA decarboxylase.	malonic acid	78-86	acyl-CoA synthetase family member 3	Homo sapiens	17-22
30225479-1	2018	The coordination chemistry of Co(ii) with the chelating dicarboxylate ligand esp (esp = alpha,alpha,alpha",alpha"-tetramethyl-1,3-benzenedipropionate) is explored.	malonic acid	56-69	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	77-80
30225479-1	2018	The coordination chemistry of Co(ii) with the chelating dicarboxylate ligand esp (esp = alpha,alpha,alpha",alpha"-tetramethyl-1,3-benzenedipropionate) is explored.	malonic acid	56-69	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	82-85
30092627-5	2018	Next, the exchange of byproducts (succinate and fumarate) between the cytosol and mitochondria was regulated by the expression of a dicarboxylate carrier Sfc1p from Saccharomyces cerevisiae in the mitochondria, which increased l-malate titer 3.5% and decreased succinate concentration 36.8%.	malonic acid	132-145	Sfc1p	Saccharomyces cerevisiae S288C	154-159
30410862-0	2018	In silico identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network.	malonic acid	71-84	translocated promoter region, nuclear basket protein	Homo sapiens	91-94
30410862-1	2018	Dicarboxylate clamp tetratricopeptide repeat (dcTPR) motif-containing proteins are well-known partners of the heat shock protein (Hsp) 70 and Hsp90 molecular chaperones.	malonic acid	0-13	heat shock protein family A (Hsp70) member 4	Homo sapiens	110-137
30410862-1	2018	Dicarboxylate clamp tetratricopeptide repeat (dcTPR) motif-containing proteins are well-known partners of the heat shock protein (Hsp) 70 and Hsp90 molecular chaperones.	malonic acid	0-13	heat shock protein 90 alpha family class A member 1	Homo sapiens	142-147
29383416-2	2018	Here we investigate if the apical CaSR in the proximal tubule also prevents stone formation acting via regulation of apical dicarboxylate and citrate transport.	malonic acid	124-137	calcium sensing receptor	Homo sapiens	34-38
29383416-6	2018	Using isotope labeled succinate uptake in OK cells along with various pharmacologic tools we examined whether the CaSR alters apical dicarboxylate transport and through which signal transduction pathways this occurs.	malonic acid	133-146	calcium sensing receptor	Homo sapiens	114-118
29383416-7	2018	Our results indicate that in the proximal tubule CaSR adjusts apical dicarboxylate transport, and does so via a CaSR   Gq   PKC signaling pathway.	malonic acid	69-82	calcium sensing receptor	Homo sapiens	49-53
29796494-2	2018	These compounds were obtained from the controlled hydrolysis of Np4+ in the presence of dicarboxylate ligands.	malonic acid	88-101	proteinase 3	Homo sapiens	64-67
29371401-0	2018	Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.	malonic acid	130-144	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	0-27
28942194-4	2018	Although the transport of mGSH is not fully understood, SLC25A10 (dicarboxylate carrier, DIC) and SLC25A11 (2-oxoglutarate carrier, OGC) have been involved in mGSH transport, and therefore we examined their expression and role in HCC.	malonic acid	66-79	solute carrier family 25 member 10	Homo sapiens	56-64
29371401-0	2018	Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.	malonic acid	130-144	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	29-33
29371401-0	2018	Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.	malonic acid	130-144	uncoupling protein 2	Arabidopsis thaliana	38-42
29079741-5	2017	The results demonstrated that the Hsp90 C-terminal peptide binds to the TPR domain of FKBP51 with the help of di-carboxylate clamp involving Lys272, Glu273, Lys352, Asn322, and Lys329 which are conserved throughout several di-carboxylate clamp TPR proteins.	malonic acid	110-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39
29096064-7	2017	A crystal structure of the AprA MT1-GNAT di-domain with bound Mn2+, malonate, and the methyl donor S-adenosylmethionine (SAM) reveals that the malonyl substrate is a bidentate metal ligand, indicating that the metal acts as a Lewis acid to promote methylation of the malonyl alpha-carbon.	malonic acid	68-76	metallothionein 1I, pseudogene	Homo sapiens	32-35
29402957-0	2018	Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.	malonic acid	92-100	aminoadipate-semialdehyde synthase	Mus musculus	24-47
29402957-8	2018	In conclusion, inhibition of SDH with intracoronary malonate during early reperfusion limits reperfusion injury and infarct size in pigs submitted to transient coronary occlusion without modifying reperfusion arrhythmias or contractile function in distant myocardium.	malonic acid	52-60	aminoadipate-semialdehyde synthase	Mus musculus	29-32
29056341-4	2017	Cells lacking CLYBL accumulate citramalyl-CoA, an intermediate in the C5-dicarboxylate metabolic pathway that includes itaconate, a recently identified human anti-microbial metabolite and immunomodulator.	malonic acid	73-86	citramalyl-CoA lyase	Homo sapiens	14-19
29079741-5	2017	The results demonstrated that the Hsp90 C-terminal peptide binds to the TPR domain of FKBP51 with the help of di-carboxylate clamp involving Lys272, Glu273, Lys352, Asn322, and Lys329 which are conserved throughout several di-carboxylate clamp TPR proteins.	malonic acid	223-237	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39
28165703-0	2017	Flexible Zirconium MOF as the Crystalline Sponge for Coordinative Alignment of Dicarboxylates.	malonic acid	79-93	lysine acetyltransferase 8	Homo sapiens	19-22
30271272-3	2017	Herein, we demonstrate the suitability of bio-based ionic liquids (ILs) formed by the cholinium cation and dicarboxylate-based anions as potential media for enzymes, in which remarkable enhanced activity and improved stability of Cyt C against multiple stresses were obtained.	malonic acid	107-120	cytochrome c, somatic	Homo sapiens	230-235
28479296-2	2017	Intramitochondrial malonyl-CoA is generated by a malonyl-CoA synthetase, ACSF3, which produces malonyl-CoA from malonate, an endogenous competitive inhibitor of succinate dehydrogenase.	malonic acid	112-120	acyl-CoA synthetase family member 3	Homo sapiens	73-78
28608694-10	2017	Together with three previous X-ray structures of iron complexes in the alphaalphabetabeta conformation, the structure of the cavity and the shape of the relaxed distal strap are also discussed with the consideration of the resolution of X-ray structures of two different free-base ligands in the alphaalphabetabeta conformation, with one bearing the ethyl malonate group and the second one bearing the malonic acid group.	malonic acid	402-414	serine/threonine kinase receptor associated protein	Homo sapiens	168-173
28479296-4	2017	ACSF3 KO cells exhibited elevated malonate and impaired mitochondrial metabolism.	malonic acid	34-42	acyl-CoA synthetase family member 3	Homo sapiens	0-5
28479296-6	2017	While ACSF3 was required for the metabolism and therefore detoxification of malonate, ACSF3-derived malonyl-CoA was specifically required for lysine malonylation of mitochondrial proteins.	malonic acid	76-84	acyl-CoA synthetase family member 3	Homo sapiens	6-11
28644952-1	2017	In this issue of Cell Chemical Biology, Bowman and colleagues show that the mitochondrial enzyme ACSF3 generates malonyl-CoA from malonate, in turn regulating metabolic flux and mitochondrial protein malonylation (Bowman et al., 2017).	malonic acid	130-138	acyl-CoA synthetase family member 3	Homo sapiens	97-102
28479296-7	2017	Together, these data describe an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism.	malonic acid	107-115	acyl-CoA synthetase family member 3	Homo sapiens	52-57
28570579-8	2017	Two IR-associated genes, KLF15 encoding a transcription factor and SLC25A10 encoding a dicarboxylate carrier, were selected for functional evaluation in adipocytes differentiated in vitro.	malonic acid	87-100	solute carrier family 25 member 10	Homo sapiens	67-75
28025701-3	2017	The flux control coefficient (FCC) identified overexpressing isocitrate dehydrogenase (IDH1), a rate-controlling flux for ethanol fermentation, and dicarboxylate carrier (DIC1), a limiting flux for cell growth, as keys of furfural-resistance phenotype.	malonic acid	148-161	Dic1p	Saccharomyces cerevisiae S288C	171-175
27927654-2	2017	Although luminal dicarboxylate reabsorption via NaDC1 (SLC13A2) is believed to be the primary mechanism regulating renal dicarboxylate transport, the specific localization of NaDC1 in the human kidney is currently unknown.	malonic acid	17-30	solute carrier family 13 member 2	Homo sapiens	48-53
28025687-1	2017	Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins.	malonic acid	78-91	glycolipid transfer protein	Homo sapiens	54-58
28247897-0	2017	Solvothermal self-assembly of Cd2+ coordination polymers with supramolecular networks involving N-donor ligands and aromatic dicarboxylates: synthesis, crystal structure and photoluminescence studies.	malonic acid	125-139	CD2 molecule	Homo sapiens	30-33
27927654-2	2017	Although luminal dicarboxylate reabsorption via NaDC1 (SLC13A2) is believed to be the primary mechanism regulating renal dicarboxylate transport, the specific localization of NaDC1 in the human kidney is currently unknown.	malonic acid	17-30	solute carrier family 13 member 2	Homo sapiens	55-62
27614971-3	2017	The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates.	malonic acid	271-285	solute carrier family 22 member 6	Homo sapiens	171-175
27927654-2	2017	Although luminal dicarboxylate reabsorption via NaDC1 (SLC13A2) is believed to be the primary mechanism regulating renal dicarboxylate transport, the specific localization of NaDC1 in the human kidney is currently unknown.	malonic acid	121-134	solute carrier family 13 member 2	Homo sapiens	55-62
27614971-3	2017	The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates.	malonic acid	271-285	solute carrier family 22 member 6	Homo sapiens	177-184
27927654-11	2017	These studies provide important information regarding NaDC1"s role in human dicarboxylate metabolism.	malonic acid	76-89	solute carrier family 13 member 2	Homo sapiens	54-59
27614971-3	2017	The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates.	malonic acid	271-285	solute carrier family 22 member 8	Homo sapiens	190-194
27614971-3	2017	The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates.	malonic acid	271-285	solute carrier family 22 member 8	Homo sapiens	196-203
27942632-1	2016	By using Gd2O3, propanedioic acid (H2pda) and oxalic acid (H2ox), a new Gd-based metal-organic framework (MOF) [Gd(pda)(ox)0.5(H2O)2]n (1) has been successfully constructed and structurally characterized.	malonic acid	16-33	lysine acetyltransferase 8	Homo sapiens	81-110
29055942-4	2017	METHODS: Using Xenopus laevis oocytes expressing either human EAAT1, 2, or 3, or human sodium-dependent dicarboxylate transporter 3 (NaDC3), transport-associated currents of NAG, NCG, and related dicarboxylates were assayed.	malonic acid	196-210	solute carrier family 13 member 3	Homo sapiens	133-138
29055942-9	2017	In NaDC3-expressing oocytes, all dicarboxylates induced much larger inward currents than did L-aspartate and L-glutamate.	malonic acid	33-47	solute carrier family 13 member 3	Homo sapiens	3-8
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	malonic acid	121-129	pyruvate carboxylase	Homo sapiens	26-28
27683012-0	2016	Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.	malonic acid	80-93	solute carrier family 13 member 5	Homo sapiens	62-66
27683012-0	2016	Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.	malonic acid	80-93	solute carrier family 13 member 5	Homo sapiens	68-75
27493727-0	2016	Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells.	malonic acid	0-8	pyruvate carboxylase	Homo sapiens	45-65
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	malonic acid	121-129	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	270-293
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	malonic acid	121-129	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	295-298
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	malonic acid	238-246	pyruvate carboxylase	Homo sapiens	26-28
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	malonic acid	238-246	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	270-293
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	malonic acid	238-246	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	295-298
26484935-2	2016	The effect upon the HO2 uptake coefficient gamma of adding different organic species (malonic acid, citric acid, 1,2-diaminoethane, tartronic acid, ethylenediaminetetraacetic acid (EDTA), and oxalic acid) into the copper(II)-doped aerosols was investigated.	malonic acid	86-98	heme oxygenase 2	Homo sapiens	20-23
26133542-5	2016	This study was aimed at the identification of novel SR inhibitor by mimicking malonic acid, the best-known SR inhibitor, with a cyclopropane scaffold.	malonic acid	78-90	serine racemase	Homo sapiens	52-54
26133542-5	2016	This study was aimed at the identification of novel SR inhibitor by mimicking malonic acid, the best-known SR inhibitor, with a cyclopropane scaffold.	malonic acid	78-90	serine racemase	Homo sapiens	107-109
26748070-9	2016	Oxidative injury was emulated in vivo by injecting of malonic acid into the rat brain, and we showed that the treatment with RX409 or RX426 inhibited GAPDH-mediated aggregation in the brain, reduced areas of the injury as proved by magnetic resonance imaging, and augmented the behavioral status of the rats as established by the "beam walking" test.	malonic acid	54-66	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	150-155
26915364-1	2016	BACKGROUND: The presence of increased urinary concentrations of both methylmalonic acid (MMA) and malonic acid (MA) is assumed to differentiate combined malonic and methylmalonic aciduria (CMAMMA), due to mutations in the ACSF3 gene, from other causes of methylmalonic aciduria (classic MMAemia).	malonic acid	75-87	acyl-CoA synthetase family member 3	Homo sapiens	222-227
26620127-4	2015	The studies herein report the identification and characterization of a novel small dicarboxylate molecule (compound 2) capable of selectively and potently inhibiting citrate transport through NaCT, both in vitro and in vivo.	malonic acid	83-96	solute carrier family 13 member 5	Homo sapiens	192-196
26051274-6	2015	Malonate, an inhibitor of succinate dehydrogenase (SDH), increased succinate levels in cultured HSCs and increased GPR91 and alpha-SMA expression.	malonic acid	0-8	aminoadipate-semialdehyde synthase	Mus musculus	26-49
26051274-6	2015	Malonate, an inhibitor of succinate dehydrogenase (SDH), increased succinate levels in cultured HSCs and increased GPR91 and alpha-SMA expression.	malonic acid	0-8	aminoadipate-semialdehyde synthase	Mus musculus	51-54
26051274-6	2015	Malonate, an inhibitor of succinate dehydrogenase (SDH), increased succinate levels in cultured HSCs and increased GPR91 and alpha-SMA expression.	malonic acid	0-8	succinate receptor 1	Mus musculus	115-120
26051274-6	2015	Malonate, an inhibitor of succinate dehydrogenase (SDH), increased succinate levels in cultured HSCs and increased GPR91 and alpha-SMA expression.	malonic acid	0-8	actin alpha 2, smooth muscle, aorta	Mus musculus	125-134
26239684-5	2015	Two inner membrane organic anion carriers, the dicarboxylate carrier (DIC; Slc25a10) and 2-oxoglutarate carrier (OGC; Slc25a11) are responsible for this transport.	malonic acid	47-60	solute carrier family 25 member 10	Rattus norvegicus	75-83
26239684-5	2015	Two inner membrane organic anion carriers, the dicarboxylate carrier (DIC; Slc25a10) and 2-oxoglutarate carrier (OGC; Slc25a11) are responsible for this transport.	malonic acid	47-60	solute carrier family 25 member 11	Rattus norvegicus	89-111
26239684-5	2015	Two inner membrane organic anion carriers, the dicarboxylate carrier (DIC; Slc25a10) and 2-oxoglutarate carrier (OGC; Slc25a11) are responsible for this transport.	malonic acid	47-60	solute carrier family 25 member 11	Rattus norvegicus	113-116
26239684-5	2015	Two inner membrane organic anion carriers, the dicarboxylate carrier (DIC; Slc25a10) and 2-oxoglutarate carrier (OGC; Slc25a11) are responsible for this transport.	malonic acid	47-60	solute carrier family 25 member 11	Rattus norvegicus	118-126
26870577-4	2016	Each malonate ligand is involved in the formation of six-membered chelate rings involving one Co(II) atom of the dinuclear unit and at the same time is coordinating to another Co(II) atom of a neighbouring dinuclear unit in a bridging mode.	malonic acid	5-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-100
26870577-4	2016	Each malonate ligand is involved in the formation of six-membered chelate rings involving one Co(II) atom of the dinuclear unit and at the same time is coordinating to another Co(II) atom of a neighbouring dinuclear unit in a bridging mode.	malonic acid	5-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-182
26477380-8	2016	A model of malonyl-CoA and malonate binding to human CPT II was suggested by docking studies to explain the action of the inhibitors regarding to the effect of the mutation on the protein conformation.	malonic acid	27-35	carnitine palmitoyltransferase 2	Homo sapiens	53-59
26787461-8	2016	Overall, malonate stimulation triggers mitochondrial stress and induces the assembly of non-canonical cellular SGs via 4EBP1 pathway.	malonic acid	9-17	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	119-124
25854324-1	2015	X-ray crystal structures of human serum transferrin (77 kDa) with Yb(III) or Fe(III) bound to the C-lobe and malonate as the synergistic anion show that the large Yb(III) ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.	malonic acid	109-117	transferrin	Homo sapiens	40-51