PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11063030-5	1998	The direct phosphoserine analysis on the purified bovine 20 kDa amelogenin indicated the presence of 0.8 moles of phosphoserine/mole protein naturally occurring, consistent with the quantitative analysis of 14C-radiolabeling of phosphoserines by conversion to dehydroalanine and in situ reaction with the thiol agent, 14C-mercaptoethanol, 0.64 moles 14C-incorporated/mole 20 kDa amelogenin.	dehydroalanine	260-274	amelogenin, X isoform	Bos taurus	64-74
9871726-0	1998	A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.	dehydroalanine	65-79	tachykinin receptor 2	Rattus norvegicus	21-42
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	dehydroalanine	33-52	cystathionine beta-synthase	Homo sapiens	78-81
8204579-0	1994	Identification of serine-143 as the most likely precursor of dehydroalanine in the active site of histidine ammonia-lyase.	dehydroalanine	61-75	histidine ammonia-lyase	Homo sapiens	98-121
8664267-8	1996	The alpha-aminoacrylate intermediate decays to generate a species absorbing maximally at 418 nm, resulting from attack of the cysteine thiol to give ether in external Schiff base linkage with the active site PLP.	dehydroalanine	4-23	proteolipid protein 1	Homo sapiens	208-211
7756277-1	1995	Anhydrothrombin, a catalytically inactive derivative of thrombin in which dehydroalanine replaces the active-site serine, was prepared by a novel method.	dehydroalanine	74-88	coagulation factor II, thrombin	Homo sapiens	7-15
7756277-2	1995	The active-site serine of thrombin was modified to dehydroalanine by promoting the beta-elimination of phenylmethylsulfonic acid from phenylmethylsulfonyl fluoride-inactivated thrombin under conditions in which the enzyme is unfolded.	dehydroalanine	51-65	coagulation factor II, thrombin	Homo sapiens	26-34
7756277-2	1995	The active-site serine of thrombin was modified to dehydroalanine by promoting the beta-elimination of phenylmethylsulfonic acid from phenylmethylsulfonyl fluoride-inactivated thrombin under conditions in which the enzyme is unfolded.	dehydroalanine	51-65	coagulation factor II, thrombin	Homo sapiens	176-184
9398272-1	1997	The reaction of the substrate O-acetyl-L-serine (OAS) with the pyridoxal 5"-phosphate (PLP)-dependent enzyme O-acetylserine sulfhydrylase-A (OASS-A) proceeds via the transient formation of an external aldimine absorbing at 420 nm and a stable alpha-aminoacrylate intermediate absorbing at 330 and 465 nm.	dehydroalanine	243-262	pyridoxal phosphatase	Homo sapiens	87-90
7961661-3	1994	Histidase and phenylalanine ammonia-lyase are the only two enzymes that have been postulated to require the modified amino acid, dehydroalanine, for enzyme activity.	dehydroalanine	129-143	histidine ammonia lyase	Rattus norvegicus	0-9
8204579-6	1994	To investigate the possible role of serine as a precursor of dehydroalanine in the active site of histidase, each of the four serines, conserved in all known histidases and phenylalanine ammonia-lyases, was consecutively changed to alanine by site-directed mutagenesis.	dehydroalanine	61-75	histidine ammonia-lyase	Homo sapiens	98-107
2120224-3	1990	Apart from phenylalanine ammonia-lyase, which is not expressed in animals, histidase is the only enzyme known to have a dehydroalanine residue in its active site.	dehydroalanine	120-134	histidine ammonia lyase	Rattus norvegicus	75-84
1537807-6	1992	High concentrations of potassium cyanide inactivated histidase in the absence of its substrate or histidinol phosphate, suggesting that, as in other histidases, dehydroalanine plays an important role in catalysis.	dehydroalanine	161-175	histidine ammonia-lyase	Homo sapiens	53-62
1943682-4	1991	In this review we discuss current research on: (1) the mechanism of formation of an unusual residue, dehydroalanine, at the active site of histidase; and (2) the role of urocanic acid as an ultraviolet light-induced immunoregulator in the skin, and the implications of urocanic acid deficiency for human histidinemia.	dehydroalanine	101-115	histidine ammonia-lyase	Homo sapiens	139-148
2120224-5	1990	As an initial step to determining the precursor of dehydroalanine in histidase, we have isolated a functional cDNA clone for histidase from a rat liver cDNA library using an affinity-purified antiserum.	dehydroalanine	51-65	histidine ammonia lyase	Rattus norvegicus	69-78
2120224-5	1990	As an initial step to determining the precursor of dehydroalanine in histidase, we have isolated a functional cDNA clone for histidase from a rat liver cDNA library using an affinity-purified antiserum.	dehydroalanine	51-65	histidine ammonia lyase	Rattus norvegicus	125-134
2120224-10	1990	The formation of active histidase in cells that have no endogenous histidase activity suggests either that the requisite modifying enzyme is present in these cells or that the dehydroalanine residue forms by an autocatalytic mechanism.	dehydroalanine	176-190	histidine ammonia lyase	Rattus norvegicus	24-33
2120224-13	1990	On the basis of the similarity of function of histidase and phenylalanine ammonia-lyase, dehydroalanine at the active sites, and the sequence conservation over a large evolutionary distance (mammals, bacteria, yeast, and plants), we propose that the genes for histidase and phenylalanine ammonia-lyase have diverged from a common ancestral gene, of which the most conserved regions are likely to be involved in catalysis or dehydroalanine formation.	dehydroalanine	424-438	histidine ammonia lyase	Rattus norvegicus	46-55
2120224-13	1990	On the basis of the similarity of function of histidase and phenylalanine ammonia-lyase, dehydroalanine at the active sites, and the sequence conservation over a large evolutionary distance (mammals, bacteria, yeast, and plants), we propose that the genes for histidase and phenylalanine ammonia-lyase have diverged from a common ancestral gene, of which the most conserved regions are likely to be involved in catalysis or dehydroalanine formation.	dehydroalanine	424-438	histidine ammonia lyase	Rattus norvegicus	260-269
6347188-0	1983	The formation of dehydroalanine residues in alkali-treated insulin and oxidized glutathione.	dehydroalanine	17-31	insulin	Homo sapiens	59-66
3396754-0	1988	Colorimetry of dehydroalanine residues preserved as "lost side chains" in thyroglobulin.	dehydroalanine	15-29	thyroglobulin	Homo sapiens	74-87
3396754-1	1988	We developed a new assay method for dehydroalanine residues in thyroglobulin, which had been proposed to be the "lost side chains" during thyroid hormonogenesis.	dehydroalanine	36-50	thyroglobulin	Homo sapiens	63-76
3396754-7	1988	The results indicate that when one hormone residue is produced by the coupling of two iodotyrosine residues, the "lost side chain" is preserved as one dehydroalanine residue in the thyroglobulin molecule.	dehydroalanine	151-165	thyroglobulin	Homo sapiens	181-194
3284836-0	1988	Analogues of luteinizing hormone-releasing hormone (LH-RH) containing dehydroalanine in 6th position.	dehydroalanine	70-84	gonadotropin releasing hormone 1	Homo sapiens	13-50
3284836-0	1988	Analogues of luteinizing hormone-releasing hormone (LH-RH) containing dehydroalanine in 6th position.	dehydroalanine	70-84	gonadotropin releasing hormone 1	Homo sapiens	52-57
2345166-0	1990	Location of dehydroalanine residues in the amino acid sequence of bovine thyroglobulin.	dehydroalanine	12-26	thyroglobulin	Bos taurus	73-86
2345166-2	1990	Thyroid hormonogenesis in thyroglobulin results in the conversion of an "acceptor" iodotyrosine to a hormone residue and a "donor" iodotyrosine to a dehydroalanine residue.	dehydroalanine	149-163	thyroglobulin	Homo sapiens	26-39
2345166-4	1990	To search for donor sites, we treated bovine thyroglobulin with 4-aminothiophenol to specifically modify dehydroalanine residues to S-(4-aminophenyl)cysteine (APC) residues, according to the principle of dehydroalanine determination developed by us (Kondo, T., Kondo, Y., and Ui, N. (1988) Mol.	dehydroalanine	105-119	thyroglobulin	Bos taurus	45-58
3096851-1	1986	Phenylethylaminoalanine (PEAA), derived from biogenic phenylethylamine and dehydroalanine, inhibited the enzymatic activity of the metalloenzyme, carboxypeptidase A (CPA).	dehydroalanine	75-89	carboxypeptidase A1	Homo sapiens	146-164
3096851-1	1986	Phenylethylaminoalanine (PEAA), derived from biogenic phenylethylamine and dehydroalanine, inhibited the enzymatic activity of the metalloenzyme, carboxypeptidase A (CPA).	dehydroalanine	75-89	carboxypeptidase A1	Homo sapiens	166-169
6347188-3	1983	measurements enable direct observation of the rate of formation of dehydroalanine residues resulting from lysis of the disulphide bonds of insulin and oxidized glutathione in base at pD13.	dehydroalanine	67-81	insulin	Homo sapiens	139-146
5354969-0	1969	Dehydroalanine in histidine ammonia lyase.	dehydroalanine	0-14	histidine ammonia-lyase	Homo sapiens	18-41
33006472-6	2020	Oxidative selenoxide elimination generates the electrophilic center, dehydroalanine, which upon Michael addition with C-terminal modified ubiquitin, a nucleophile, yield Ub tagged SUMO2.	dehydroalanine	69-83	small ubiquitin like modifier 2	Homo sapiens	180-185
32958252-3	2020	A phase II generated metabolite of busulfan, EdAG (gamma-glutamyldehydroalanylglycine), is a dehydroalanine analog of glutathione (GSH) with an electrophilic moiety, suggesting it may bind to proteins and disrupt biological function.	dehydroalanine	93-107	hemogen	Homo sapiens	45-49
28106097-3	2017	A recent proposal suggested that LanCL1 catalyzes the addition of the Cys of glutathione to protein- or peptide-bound dehydroalanine (Dha) to form lanthionine, analogous to the reaction catalyzed by LanC in bacteria.	dehydroalanine	118-132	LanC (bacterial lantibiotic synthetase component C)-like 1	Mus musculus	33-39
31742803-0	2020	Co(III)-Catalyzed C-H Amidation of Dehydroalanine for the Site-Selective Structural Diversification of Thiostrepton.	dehydroalanine	35-49	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	3-6
31742803-2	2020	In this work, the first C(sp2)-H amidation of dehydroalanine (Dha) residues was applied to the site selective modification of thiostrepton to prepare a variety of derivatives.	dehydroalanine	46-60	Sp2 transcription factor	Homo sapiens	24-29
31742803-2	2020	In this work, the first C(sp2)-H amidation of dehydroalanine (Dha) residues was applied to the site selective modification of thiostrepton to prepare a variety of derivatives.	dehydroalanine	62-65	Sp2 transcription factor	Homo sapiens	24-29
31742803-6	2020	The exceptional functional group compatibility and site selectivity of Co(III)-catalyzed C(sp2)-H Dha amidation suggests that this approach could be generalized to other natural products and biopolymers containing Dha residues.	dehydroalanine	98-101	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-77
31742803-6	2020	The exceptional functional group compatibility and site selectivity of Co(III)-catalyzed C(sp2)-H Dha amidation suggests that this approach could be generalized to other natural products and biopolymers containing Dha residues.	dehydroalanine	98-101	Sp2 transcription factor	Homo sapiens	89-94
31742803-6	2020	The exceptional functional group compatibility and site selectivity of Co(III)-catalyzed C(sp2)-H Dha amidation suggests that this approach could be generalized to other natural products and biopolymers containing Dha residues.	dehydroalanine	214-217	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	71-77
31742803-6	2020	The exceptional functional group compatibility and site selectivity of Co(III)-catalyzed C(sp2)-H Dha amidation suggests that this approach could be generalized to other natural products and biopolymers containing Dha residues.	dehydroalanine	214-217	Sp2 transcription factor	Homo sapiens	89-94
30451505-1	2018	The cypemycin decarboxylase CypD is investigated by using a synthetic oligopeptide, which contains the to-be-cyclized dehydroalanine (Dha) residue.	dehydroalanine	118-132	peptidylprolyl isomerase D	Homo sapiens	28-32
30451505-1	2018	The cypemycin decarboxylase CypD is investigated by using a synthetic oligopeptide, which contains the to-be-cyclized dehydroalanine (Dha) residue.	dehydroalanine	134-137	peptidylprolyl isomerase D	Homo sapiens	28-32
30451505-2	2018	It was shown that CypD efficiently catalyzes the decarboxylation of this Dha-containing peptide, but the expected AviCys ring is not formed in the product, suggesting that CypD alone is not enough to form the AviCys ring.	dehydroalanine	73-76	peptidylprolyl isomerase D	Homo sapiens	18-22
30181125-9	2018	Based on the collective data presented here in, PA5339 was renamed RidA.IMPORTANCE RidA is a widely conserved protein that prevents endogenous metabolic stress caused by 2-aminoacrylate (2AA) damage to pyridoxal 5"-phosphate (PLP)-dependent enzymes in prokaryotes and eukaryotes.	dehydroalanine	170-185	hypothetical protein	Pseudomonas aeruginosa PAO1	48-54
29527788-0	2018	Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential alpha-Globin-Modulating Deubiquitinase.	dehydroalanine	57-71	hemoglobin subunit alpha 2	Homo sapiens	132-144
29440254-1	2018	The RidA protein (PF01042) from Salmonella enterica is a deaminase that quenches 2-aminoacrylate (2AA) and other reactive metabolites.	dehydroalanine	81-96	reactive intermediate imine deaminase A homolog	Homo sapiens	4-8
29440254-6	2018	These results uncovered a new mechanism to ameliorate metabolic stress, and they suggest that direct quenching by RidA is not the only strategy to quench 2AA.IMPORTANCE 2-Aminoacrylate is an endogenously generated reactive metabolite that can damage cellular enzymes if not directly quenched by the conserved deaminase RidA.	dehydroalanine	169-184	reactive intermediate imine deaminase A homolog	Homo sapiens	114-118
29440254-6	2018	These results uncovered a new mechanism to ameliorate metabolic stress, and they suggest that direct quenching by RidA is not the only strategy to quench 2AA.IMPORTANCE 2-Aminoacrylate is an endogenously generated reactive metabolite that can damage cellular enzymes if not directly quenched by the conserved deaminase RidA.	dehydroalanine	169-184	reactive intermediate imine deaminase A homolog	Homo sapiens	319-323
29487232-6	2018	The RidA family protein Mmf1p deaminates 2-aminoacrylate, preempting metabolic stress and loss of the mitochondrial genome.	dehydroalanine	41-56	isoleucine biosynthesis protein MMF1	Saccharomyces cerevisiae S288C	24-29
29487232-7	2018	Disruption of the mitochondrial pyridoxal 5"-phosphate-dependent serine dehydratases (Ilv1p and Cha1p) prevents 2-aminoacrylate formation, avoiding stress in the absence of Mmf1p.	dehydroalanine	112-127	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	86-91
29487232-7	2018	Disruption of the mitochondrial pyridoxal 5"-phosphate-dependent serine dehydratases (Ilv1p and Cha1p) prevents 2-aminoacrylate formation, avoiding stress in the absence of Mmf1p.	dehydroalanine	112-127	L-serine/L-threonine ammonia-lyase CHA1	Saccharomyces cerevisiae S288C	96-101
29487232-9	2018	Taken together, the data indicate that Mmf1p indirectly contributes to mitochondrial DNA maintenance by preventing 2-aminoacrylate stress derived from mitochondrial amino acid metabolism.IMPORTANCE Deleterious reactive metabolites are produced as a consequence of many intracellular biochemical transformations.	dehydroalanine	115-130	isoleucine biosynthesis protein MMF1	Saccharomyces cerevisiae S288C	39-44
28497355-6	2017	The Dha residues facilitate preferential backbone cleavages to produce signature c- and z-ions, demonstrated with cations derived from melittin, mechano growth factor (MGF), and ubiquitin.	dehydroalanine	4-7	insulin like growth factor 1	Homo sapiens	145-166
28497355-6	2017	The Dha residues facilitate preferential backbone cleavages to produce signature c- and z-ions, demonstrated with cations derived from melittin, mechano growth factor (MGF), and ubiquitin.	dehydroalanine	4-7	insulin like growth factor 1	Homo sapiens	168-171
28528273-0	2017	Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C.	dehydroalanine	62-76	cathepsin C	Homo sapiens	110-121
28592682-9	2017	Modeling and direct investigation of the N-terminal sequence of betaA4 crystallin, as well as a variety of homologous peptides, showed that the epsilon amino group of Lys can promote DHA production by nucleophilic attack on the alpha proton of cystine.	dehydroalanine	183-186	crystallin beta A4	Homo sapiens	64-81
32302100-3	2020	Employing this USP7 variant, we found that inhibitors with a cyanopyrrolidine warhead unexpectedly promoted a beta-elimination reaction of the initial covalent adducts, thereby converting the active-site cysteine residue to dehydroalanine.	dehydroalanine	224-238	ubiquitin specific peptidase 7	Homo sapiens	15-19
32302100-3	2020	Employing this USP7 variant, we found that inhibitors with a cyanopyrrolidine warhead unexpectedly promoted a beta-elimination reaction of the initial covalent adducts, thereby converting the active-site cysteine residue to dehydroalanine.	dehydroalanine	224-238	amyloid beta precursor protein	Homo sapiens	108-114
28919039-2	2017	By replacing Gly76 in distal ubiquitin (Ub) by dehydroalanine we designed the diubiquitin (diUb) activity-based probe UbG76Dha-Ub (OTULIN activity-based probe [ABP]) that couples to the catalytic site of OTULIN and thereby captures OTULIN in its active conformation.	dehydroalanine	47-61	ubiquitin D	Homo sapiens	78-89
28919039-2	2017	By replacing Gly76 in distal ubiquitin (Ub) by dehydroalanine we designed the diubiquitin (diUb) activity-based probe UbG76Dha-Ub (OTULIN activity-based probe [ABP]) that couples to the catalytic site of OTULIN and thereby captures OTULIN in its active conformation.	dehydroalanine	47-61	OTU deubiquitinase with linear linkage specificity	Homo sapiens	131-137
28106097-3	2017	A recent proposal suggested that LanCL1 catalyzes the addition of the Cys of glutathione to protein- or peptide-bound dehydroalanine (Dha) to form lanthionine, analogous to the reaction catalyzed by LanC in bacteria.	dehydroalanine	134-137	LanC (bacterial lantibiotic synthetase component C)-like 1	Mus musculus	33-39
26794841-5	2016	Analysis of SbnA crystals incubated with OPS revealed the structure of the PLP-alpha-aminoacrylate intermediate.	dehydroalanine	79-98	pyridoxal phosphatase	Homo sapiens	75-78
27405778-7	2016	By combining state-of-the-art ultra-high-pressure liquid chromatography-mass spectrometry metabolic flux analysis with redox and switch-tag proteomics, we identify for the first time ex vivo functionally relevant reversible and irreversible (sulfinic acid; Cys to dehydroalanine) oxidations of GAPDH without exogenous supplementation of excess pro-oxidant compounds in clinically relevant blood products.	dehydroalanine	264-278	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	294-299
27490699-3	2016	In contrast, here we demonstrate that incubation of busulfan with the thiol redox proteins glutaredoxin or thioredoxin at pH 7.4 and 37  C results in the formation of putative S-tetrahydrothiophenium adducts at their catalytic Cys residues, followed by beta-elimination to yield dehydroalanine.	dehydroalanine	279-293	glutaredoxin	Homo sapiens	91-103
27490699-3	2016	In contrast, here we demonstrate that incubation of busulfan with the thiol redox proteins glutaredoxin or thioredoxin at pH 7.4 and 37  C results in the formation of putative S-tetrahydrothiophenium adducts at their catalytic Cys residues, followed by beta-elimination to yield dehydroalanine.	dehydroalanine	279-293	thioredoxin	Homo sapiens	107-118
26278353-3	2015	EdAG contains the electrophilic dehydroalanine, which is expected to react with protein nucleophiles, particularly proteins with GSH binding sites such as glutaredoxins (Grx"s).	dehydroalanine	32-46	hemogen	Homo sapiens	0-4
26278353-3	2015	EdAG contains the electrophilic dehydroalanine, which is expected to react with protein nucleophiles, particularly proteins with GSH binding sites such as glutaredoxins (Grx"s).	dehydroalanine	32-46	glutaredoxin	Homo sapiens	170-173
20070187-3	2010	Mass spectrometry revealed that treatment of GPx1 with H(2)O(2) converts the selenocysteine residue at its active site to dehydroalanine (DHA).	dehydroalanine	122-136	glutathione peroxidase 1	Homo sapiens	45-49
24364494-1	2014	A strategy for the synthesis of dehydroalanine based diubiquitin activity probes is described.	dehydroalanine	32-46	ubiquitin D	Homo sapiens	53-64
24364494-2	2014	The site-specific introduction of dehydroalanine was achieved from diubiquitin bearing Cys residue near the scissile bond between two ubiquitins linked through Lys48, Lys63 or in a head to tail fashion.	dehydroalanine	34-48	ubiquitin D	Homo sapiens	67-78
22725664-2	2012	The elimination product is an electrophilic metabolite that is a dehydroalanine-containing tripeptide, gamma-glutamyldehydroalanylglycine (EdAG).	dehydroalanine	65-79	hemogen	Homo sapiens	139-143
22725664-8	2012	Observation of the hydroxyl trapping properties of EdAG suggests that the busulfan metabolite EdAG may contribute to or mitigate redox-related cytotoxicity associated with the therapeutic use of busulfan, and reaffirms indicators that support a role in free radical biology for dehydroalanine-containing peptides and proteins.	dehydroalanine	278-292	hemogen	Homo sapiens	51-55
22725664-8	2012	Observation of the hydroxyl trapping properties of EdAG suggests that the busulfan metabolite EdAG may contribute to or mitigate redox-related cytotoxicity associated with the therapeutic use of busulfan, and reaffirms indicators that support a role in free radical biology for dehydroalanine-containing peptides and proteins.	dehydroalanine	278-292	hemogen	Homo sapiens	94-98
21420488-5	2011	Most striking, mass spectrometry revealed two chemical forms of the 47th residue of GPX1: the projected native selenocysteine (Sec) and the Se-lacking dehydroalanine (DHA).	dehydroalanine	151-165	glutathione peroxidase 1	Mus musculus	84-88
21420488-5	2011	Most striking, mass spectrometry revealed two chemical forms of the 47th residue of GPX1: the projected native selenocysteine (Sec) and the Se-lacking dehydroalanine (DHA).	dehydroalanine	167-170	glutathione peroxidase 1	Mus musculus	84-88
21420488-6	2011	The hepatic GPX1 protein of the SOD1(-/-) mice contained 38% less Sec and 77% more DHA than that of WT and showed aggravated dissociation of the tetramer structure.	dehydroalanine	83-86	glutathione peroxidase 1	Mus musculus	12-16
21420488-6	2011	The hepatic GPX1 protein of the SOD1(-/-) mice contained 38% less Sec and 77% more DHA than that of WT and showed aggravated dissociation of the tetramer structure.	dehydroalanine	83-86	superoxide dismutase 1, soluble	Mus musculus	32-36
21420488-7	2011	In conclusion, knockout of SOD1 elevated the conversion of Sec to DHA in the active site of hepatic GPX1, leading to proportional decreases in the apparent k(cat) and activity of the enzyme protein as a whole.	dehydroalanine	66-69	superoxide dismutase 1, soluble	Mus musculus	27-31
21420488-7	2011	In conclusion, knockout of SOD1 elevated the conversion of Sec to DHA in the active site of hepatic GPX1, leading to proportional decreases in the apparent k(cat) and activity of the enzyme protein as a whole.	dehydroalanine	66-69	glutathione peroxidase 1	Mus musculus	100-104
20070187-3	2010	Mass spectrometry revealed that treatment of GPx1 with H(2)O(2) converts the selenocysteine residue at its active site to dehydroalanine (DHA).	dehydroalanine	138-141	glutathione peroxidase 1	Homo sapiens	45-49
20070187-4	2010	We developed a blot method for detection of DHA-containing proteins, with which we observed that the amount of DHA-containing GPx1 increases with increasing RBC density, which is correlated with increasing RBC age.	dehydroalanine	44-47	glutathione peroxidase 1	Homo sapiens	126-130
20070187-4	2010	We developed a blot method for detection of DHA-containing proteins, with which we observed that the amount of DHA-containing GPx1 increases with increasing RBC density, which is correlated with increasing RBC age.	dehydroalanine	111-114	glutathione peroxidase 1	Homo sapiens	126-130
19212810-0	2009	Two novel bovine somatotropin species generated from a common dehydroalanine intermediate.	dehydroalanine	62-76	somatotropin	Bos taurus	17-29
20609902-4	2010	We developed a convenient method for estimation of the amount of DHA-GPx1 in cell homogenates.	dehydroalanine	65-68	glutathione peroxidase 1	Homo sapiens	69-73
20609902-6	2010	The method required an immunoprecipitation of GPx1 before labeling with the cysteamine derivative because many other proteins contain DHA.	dehydroalanine	134-137	glutathione peroxidase 1	Homo sapiens	46-50
20609902-7	2010	With the use of this method, we found that conversion of the Sec residue at the active site of GPx1 to DHA occurred during aging of red blood cells (RBCs) in vivo as well as in RBCs exposed to H(2)O(2) generated either externally by glucose oxidase or internally as a result of aniline-induced Hb autoxidation.	dehydroalanine	103-106	glutathione peroxidase 1	Homo sapiens	95-99
20609902-8	2010	Accordingly, the content of DHA-GPx1 in each RBC likely reflects total oxidative stress experienced by the cell during its lifetime of 120 days.	dehydroalanine	28-31	glutathione peroxidase 1	Homo sapiens	32-36
20609902-10	2010	Therefore, DHA-GPx1 in RBCs might be a suitable surrogate marker for evaluation of oxidative stress in the body.	dehydroalanine	11-14	glutathione peroxidase 1	Homo sapiens	15-19
17289451-10	2007	The dehydroalanine was identified in similar small amounts in both recombinant and plasma-derived MBL.	dehydroalanine	4-18	mannose binding lectin 2	Homo sapiens	98-101
18265430-0	2008	Dehydroalanine derived from cysteine is a common post-translational modification in human serum albumin.	dehydroalanine	0-14	albumin	Homo sapiens	90-103
18004874-9	2007	The 320 and 506 nm species originate from conversion of the alpha-aminoacrylate external aldimine to the internal aldimine and alpha-aminoacrylate, followed by the nucleophilic attack of alpha-aminoacrylate on C-4" of the internal aldimine to give a covalent adduct with PLP.	dehydroalanine	60-79	complement C4A (Rodgers blood group)	Homo sapiens	210-213
18004874-9	2007	The 320 and 506 nm species originate from conversion of the alpha-aminoacrylate external aldimine to the internal aldimine and alpha-aminoacrylate, followed by the nucleophilic attack of alpha-aminoacrylate on C-4" of the internal aldimine to give a covalent adduct with PLP.	dehydroalanine	60-79	proteolipid protein 1	Homo sapiens	271-274
18004874-9	2007	The 320 and 506 nm species originate from conversion of the alpha-aminoacrylate external aldimine to the internal aldimine and alpha-aminoacrylate, followed by the nucleophilic attack of alpha-aminoacrylate on C-4" of the internal aldimine to give a covalent adduct with PLP.	dehydroalanine	127-146	complement C4A (Rodgers blood group)	Homo sapiens	210-213
18004874-9	2007	The 320 and 506 nm species originate from conversion of the alpha-aminoacrylate external aldimine to the internal aldimine and alpha-aminoacrylate, followed by the nucleophilic attack of alpha-aminoacrylate on C-4" of the internal aldimine to give a covalent adduct with PLP.	dehydroalanine	127-146	proteolipid protein 1	Homo sapiens	271-274
18004874-9	2007	The 320 and 506 nm species originate from conversion of the alpha-aminoacrylate external aldimine to the internal aldimine and alpha-aminoacrylate, followed by the nucleophilic attack of alpha-aminoacrylate on C-4" of the internal aldimine to give a covalent adduct with PLP.	dehydroalanine	127-146	complement C4A (Rodgers blood group)	Homo sapiens	210-213
18004874-9	2007	The 320 and 506 nm species originate from conversion of the alpha-aminoacrylate external aldimine to the internal aldimine and alpha-aminoacrylate, followed by the nucleophilic attack of alpha-aminoacrylate on C-4" of the internal aldimine to give a covalent adduct with PLP.	dehydroalanine	127-146	proteolipid protein 1	Homo sapiens	271-274
17063874-4	2006	During the process of TTR analysis, we found unique isoforms of TTR, which showed changes of the cysteine (10th from amino terminal) residue to glycine, dehydroalanine, and S-sulfocysteine residues.	dehydroalanine	153-167	transthyretin	Homo sapiens	22-25
17063874-4	2006	During the process of TTR analysis, we found unique isoforms of TTR, which showed changes of the cysteine (10th from amino terminal) residue to glycine, dehydroalanine, and S-sulfocysteine residues.	dehydroalanine	153-167	transthyretin	Homo sapiens	64-67
15183043-2	2004	Anhydrothrombin (AhT) is a catalytically inactive derivative of thrombin in which dehydroalanine replaces the active-site serine.	dehydroalanine	82-96	coagulation factor II, thrombin	Homo sapiens	7-15
11412095-9	2001	Upon reaction with L-Ser and in the presence of the alpha-site substrate analogue, alpha-glycerol phosphate, the Na(+) form of betaD305A undergoes inactivation via reaction of nascent alpha-aminoacrylate with bound PLP.	dehydroalanine	184-203	proteolipid protein 1	Homo sapiens	215-218
12146963-3	2002	Furthermore, the alpha-aminoacrylate Schiff base intermediate, E(A-A), formed between L-Ser and enzyme-bound PLP has an unusual spectrum with lambda(max) = 350 nm and a shoulder extending to greater than 500 nm.	dehydroalanine	17-36	pyridoxal phosphatase	Homo sapiens	109-112
14679512-1	2003	A chemoselective strategy for oligosaccharide-peptide ligation is described in which alpha-thio analogues of mucin-related glycoconjugates can be readily accessed through site-selective conjugate addition of complex oligosaccharide thiolates to dehydroalanine-containing peptides.	dehydroalanine	245-259	LOC100508689	Homo sapiens	109-114
12686130-3	2003	Histidine and phenylalanine ammonia-lyases (HAL and PAL) possess a catalytically essential electrophilic group which has been believed to be dehydroalanine for 30 years.	dehydroalanine	141-155	histidine ammonia-lyase	Homo sapiens	44-47
12686130-3	2003	Histidine and phenylalanine ammonia-lyases (HAL and PAL) possess a catalytically essential electrophilic group which has been believed to be dehydroalanine for 30 years.	dehydroalanine	141-155	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	52-55
14635094-5	2003	We have observed formation of dehydroalanine and dehydrovaline residues resulting from i, i+2-bridged cysteines and i, i+3-bridged cysteine/penicillamine peptides, respectively, thereby supporting a beta-elimination/Michael-addition mechanism for this transformation.	dehydroalanine	30-44	amyloid beta precursor protein	Homo sapiens	197-203
10831589-4	2000	We performed direct binding assays using anhydro-thrombin, a catalytically inactive derivative of thrombin in which the active-site serine is converted to dehydroalanine.	dehydroalanine	155-169	coagulation factor II, thrombin	Homo sapiens	49-57
11042162-11	2001	Finally, in the presence of homocysteine the alpha-aminoacrylate-enzyme absorption band readily disappears with the concomitant formation of the absorption band of the internal aldimine, indicating that cystathionine beta-synthase crystals catalyze both beta-elimination and beta-replacement reactions.	dehydroalanine	45-64	cystathionine beta-synthase	Homo sapiens	203-230
11297349-0	2001	Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity.	dehydroalanine	59-73	cathepsin C	Homo sapiens	122-133
10831589-4	2000	We performed direct binding assays using anhydro-thrombin, a catalytically inactive derivative of thrombin in which the active-site serine is converted to dehydroalanine.	dehydroalanine	155-169	coagulation factor II, thrombin	Homo sapiens	98-106
10521497-4	1999	The light chain (LCh) fragments (both 80 and 72 kDa) and the recombinant C2 domain dose-dependently bound to immobilized anhydro-FXa, a catalytically inactive derivative of FXa in which dehydroalanine replaces the active-site serine.	dehydroalanine	186-200	coagulation factor X	Homo sapiens	129-132
10845681-9	2000	The dehydroalanine-type ANP intermediate then reacted with another ANP molecule to form a non-disulfide-linked dimer through reaction with the side chain of tyrosine.	dehydroalanine	4-18	natriuretic peptide A	Homo sapiens	24-27
10845681-9	2000	The dehydroalanine-type ANP intermediate then reacted with another ANP molecule to form a non-disulfide-linked dimer through reaction with the side chain of tyrosine.	dehydroalanine	4-18	natriuretic peptide A	Homo sapiens	67-70