PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17459099-3	2007	Previous studies showed that the activity of the separately purified rhodanese-like domain of MOCS3 displayed 1000-fold lower activity in comparison to bovine rhodanese with thiosulfate as sulfur source.	Thiosulfates	174-185	molybdenum cofactor synthesis 3	Bos taurus	94-99
18020379-7	2007	The adsorption of alpha-lipoic acid to CdS in the presence of light proceeds with photo-oxidation of the CdS surface and reductive cleavage of the disulfide bond of alpha-lipoic acid to produce some adsorbed dihydrolipoic acid and thiosulfate.	Thiosulfates	231-242	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
17459099-4	2007	When the six amino acid active site loop of MOCS3 rhodanese-like domain was exchanged with the loop found in bovine rhodanese, thiosulfate:cyanide sulfurtransferase activity was increased 165-fold.	Thiosulfates	127-138	molybdenum cofactor synthesis 3	Bos taurus	44-49
17551834-3	2008	In the presence of cyanide, rhodanese shifted the major mucosal metabolite of sulfide from thiosulfate to thiocyanate.	Thiosulfates	91-102	thiosulfate sulfurtransferase	Rattus norvegicus	28-37
17551834-4	2008	The purported ability of purified rhodanese to metabolize sulfide reflects: (a) contamination with a sulfide oxidase, and (b) the spontaneous conversion of sulfide to thiosulfate during storage; rhodanese then catalyzes the conversion of this thiosulfate to thiocyanate.	Thiosulfates	167-178	thiosulfate sulfurtransferase	Rattus norvegicus	34-43
17551834-4	2008	The purported ability of purified rhodanese to metabolize sulfide reflects: (a) contamination with a sulfide oxidase, and (b) the spontaneous conversion of sulfide to thiosulfate during storage; rhodanese then catalyzes the conversion of this thiosulfate to thiocyanate.	Thiosulfates	243-254	thiosulfate sulfurtransferase	Rattus norvegicus	34-43
17551834-4	2008	The purported ability of purified rhodanese to metabolize sulfide reflects: (a) contamination with a sulfide oxidase, and (b) the spontaneous conversion of sulfide to thiosulfate during storage; rhodanese then catalyzes the conversion of this thiosulfate to thiocyanate.	Thiosulfates	243-254	thiosulfate sulfurtransferase	Rattus norvegicus	195-204
17551834-7	2008	Rhodanese then converts this thiosulfate to thiocyanate, but this reaction does not increase the rate of sulfide detoxification.	Thiosulfates	29-40	thiosulfate sulfurtransferase	Rattus norvegicus	0-9
17991026-1	2007	The soxB gene encodes the SoxB component of the periplasmic thiosulfate-oxidizing Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as intermediate.	Thiosulfates	60-71	SRY-box transcription factor 3	Homo sapiens	4-8
17991026-1	2007	The soxB gene encodes the SoxB component of the periplasmic thiosulfate-oxidizing Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as intermediate.	Thiosulfates	60-71	SRY-box transcription factor 3	Homo sapiens	26-30
17991026-1	2007	The soxB gene encodes the SoxB component of the periplasmic thiosulfate-oxidizing Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as intermediate.	Thiosulfates	229-240	SRY-box transcription factor 3	Homo sapiens	4-8
17991026-1	2007	The soxB gene encodes the SoxB component of the periplasmic thiosulfate-oxidizing Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as intermediate.	Thiosulfates	229-240	SRY-box transcription factor 3	Homo sapiens	26-30
17991026-2	2007	Indeed, the comprehensive genetic and genomic analyses presented in the present study identified the soxB gene in 121 phylogenetically and physiologically divergent SOB, including several species for which thiosulfate utilization has not been reported yet.	Thiosulfates	206-217	SRY-box transcription factor 3	Homo sapiens	101-105
17991026-3	2007	In first support of the previously postulated general involvement of components of the Sox enzyme complex in the thiosulfate oxidation process of sulfur-storing SOB, the soxB gene was detected in all investigated photo- and chemotrophic species that form sulfur globules during thiosulfate oxidation (Chromatiaceae, Chlorobiaceae, Ectothiorhodospiraceae, Thiothrix, Beggiatoa, Thiobacillus, invertebrate symbionts and free-living relatives).	Thiosulfates	113-124	SRY-box transcription factor 3	Homo sapiens	170-174
17991026-3	2007	In first support of the previously postulated general involvement of components of the Sox enzyme complex in the thiosulfate oxidation process of sulfur-storing SOB, the soxB gene was detected in all investigated photo- and chemotrophic species that form sulfur globules during thiosulfate oxidation (Chromatiaceae, Chlorobiaceae, Ectothiorhodospiraceae, Thiothrix, Beggiatoa, Thiobacillus, invertebrate symbionts and free-living relatives).	Thiosulfates	278-289	SRY-box transcription factor 3	Homo sapiens	170-174
16979290-5	2007	Strain SA2 used thiosulfate, sulfate, sulfite and elemental sulfur as electron acceptors and produced sulfide.	Thiosulfates	16-27	stromal antigen 2	Homo sapiens	7-10
16211368-3	2006	Two of the transporters, NaS1 and NaS2, carry substrates such as sulfate, selenate and thiosulfate.	Thiosulfates	87-98	solute carrier family 13 member 1	Homo sapiens	25-29
17098912-2	2007	Here we report on the presence of multiple sulfurtransferases in the cyanogenic bacterium Pseudomonas aeruginosa PAO1 and investigate in detail RhdA, a thiosulfate:cyanide sulfurtransferase (rhodanese) which converts cyanide to less toxic thiocyanate.	Thiosulfates	152-163	thiosulfate:cyanide sulfurtransferase	Pseudomonas aeruginosa PAO1	144-148
17181263-1	2006	The electrochemical oxidation of thiosulfate is revealed to have two distinct oscillatory regimes in both linear potential and galvanic voltammograms, where various nonlinear behaviors such as period-2, mixed-mode and quasi-periodic oscillations, and chaos are observed under potentiostatic or galvanostatic conditions.	Thiosulfates	33-44	period circadian regulator 2	Homo sapiens	193-201
16211368-3	2006	Two of the transporters, NaS1 and NaS2, carry substrates such as sulfate, selenate and thiosulfate.	Thiosulfates	87-98	solute carrier family 13 member 4	Homo sapiens	34-38
11161786-5	2000	Expression of hNaSi-1 protein in Xenopus oocytes demonstrated a high-affinity Na+-sulfate cotransporter that was inhibited by selenate, thiosulfate, molybdate, tungstate, citrate, and succinate.	Thiosulfates	136-147	solute carrier family 13 member 1	Homo sapiens	14-21
16099456-2	2005	Disruption of flr gene strongly inhibited the reduction of thiosulfate and exhibited a reduced growth in the presence of sulfite with lactate as electron donor.	Thiosulfates	59-70	biliverdin reductase B	Homo sapiens	14-17
16099456-4	2005	Additionally, flr mutant cells revealed a decrease of about 50% in the H2 consumption rate using thiosulfate as electron acceptor.	Thiosulfates	97-108	biliverdin reductase B	Homo sapiens	14-17
15910006-3	2005	Recent studies have shown that the MOCS3 rhodanese-like domain (MOCS3-RLD) catalyzes the transfer of sulfur from thiosulfate to cyanide and is also able to provide the sulfur for the thiocarboxylation of MOCS2A in a defined in vitro system for the generation of MPT from precursor Z.	Thiosulfates	113-124	molybdenum cofactor synthesis 3	Homo sapiens	35-40
15910006-3	2005	Recent studies have shown that the MOCS3 rhodanese-like domain (MOCS3-RLD) catalyzes the transfer of sulfur from thiosulfate to cyanide and is also able to provide the sulfur for the thiocarboxylation of MOCS2A in a defined in vitro system for the generation of MPT from precursor Z.	Thiosulfates	113-124	molybdenum cofactor synthesis 3	Homo sapiens	64-69
15607730-3	2005	Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent transport of sulfate that was inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate, but not by oxalate, citrate, succinate, phenol red or DIDS.	Thiosulfates	115-126	solute carrier family 13 member 4	Homo sapiens	14-19
11313131-0	2001	Phylogeny and distribution of the soxB gene among thiosulfate-oxidizing bacteria.	Thiosulfates	50-61	SRY-box transcription factor 3	Homo sapiens	34-38
11313131-1	2001	A PCR protocol for the detection of sulfur-oxidizing bacteria based on soxB genes that are essential for thiosulfate oxidation by sulfur-oxidizing bacteria of various phylogenetic groups which use the "Paracoccus sulfur oxidation" pathway was developed.	Thiosulfates	105-116	SRY-box transcription factor 3	Homo sapiens	71-75
11313131-2	2001	Five degenerate primers were used to specifically amplify fragments of soxB genes from different sulfur-oxidizing bacteria previously shown to oxidize thiosulfate.	Thiosulfates	151-162	SRY-box transcription factor 3	Homo sapiens	71-75
11313131-6	2001	Thiosulfate-oxidizing green sulfur bacteria formed a coherent group by their soxB sequences.	Thiosulfates	0-11	SRY-box transcription factor 3	Homo sapiens	77-81
16041477-7	2005	The presence of tetrathionate synthase, the enzyme responsible for thiosulfate oxidation, was detected in strain HG 1.	Thiosulfates	67-78	polycystin 1, transient receptor potential channel interacting pseudogene 1	Homo sapiens	113-117
16269753-5	2005	Additional experiments revealed that the level of tceA expression was independent of the concentration of chlorinated ethenes (sum concentrations of TCE and DCEs of 2.2 to 333 microM), the concentration of the electron donor hydrogen (concentrations of 12 nM to 17 microM), and the presence of alternate bacterial electron acceptors (5 mM concentrations of fumarate, sulfate, sulfite, thiosulfate, nitrate, or nitrite) but was highly dependent on incubation temperature.	Thiosulfates	385-396	transcription elongation factor A1	Homo sapiens	50-54
15700231-8	2005	An information-dependent acquisition method, where the switch criterion was loss of m/z 79.9568, specifically identified 11 thiosulfate-containing peptides using nano-LC/MS from a tryptic digest of bovine serum albumin (BSA).	Thiosulfates	124-135	albumin	Mus musculus	205-218
15073332-4	2004	The MOCS3 rhodanese-like domain (MOCS3-RLD) was purified after heterologous expression in E. coli and was shown to catalyze the transfer of sulfur from thiosulfate to cyanide.	Thiosulfates	152-163	molybdenum cofactor synthesis 3	Homo sapiens	4-9
15073332-4	2004	The MOCS3 rhodanese-like domain (MOCS3-RLD) was purified after heterologous expression in E. coli and was shown to catalyze the transfer of sulfur from thiosulfate to cyanide.	Thiosulfates	152-163	molybdenum cofactor synthesis 3	Homo sapiens	33-38
11513876-1	2001	Four proteins of Paracoccus pantotrophus are required for hydrogen sulfide-, sulfur-, thiosulfate- and sulfite-dependent horse heart cytochrome c reduction.	Thiosulfates	86-97	cytochrome c, somatic	Equus caballus	133-145
11337884-4	2001	Under the same conditions, reaction of cis-1,3-D with thiosulfate was more than three times faster than trans-1,3-D, which was correlated with a lower reaction activation energy for the cis isomer.	Thiosulfates	54-65	suppressor of cytokine signaling 1	Homo sapiens	39-44
9383735-11	1997	A thiosulfate adduct of rhuMAb HER2 was observed by cation-exchange chromatography.	Thiosulfates	2-13	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-35
10409492-7	1999	NaSi-1 specificity for the Na(+) cation was determined, and the anions selenate, molybdate, tungstate, oxalate and thiosulphate could all inhibit NaSi-1-induced sulphate transport.	Thiosulfates	115-127	solute carrier family 13 member 1 S homeolog	Xenopus laevis	146-152
9383735-12	1997	These studies demonstrate that stoichiometric amounts of methionine and thiosulfate are sufficient to eliminate temperature-induced oxidation of rhuMAb HER2 caused by free radicals that were generated by the presence of metal ion and peroxide impurities in the formulation.	Thiosulfates	72-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	152-156
7665563-3	1995	At high concentrations this renaturation also requires the substrate thiosulfate to have been present during GroEL-rhodanese complex formation.	Thiosulfates	69-80	heat shock protein family D (Hsp60) member 1	Homo sapiens	109-114
9224564-7	1997	Sulphite was a competitive inhibitor vs thiosulphate for rhodanese isolated from normal liver and a hyperbolic activator for the enzyme isolated from liver of DAB-treated animals.	Thiosulfates	40-52	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	57-66
8910318-10	1996	Arg187 is suggested to be a binding site of both mercaptopyruvate and thiosulfate in MST.	Thiosulfates	70-81	mercaptopyruvate sulfurtransferase	Rattus norvegicus	85-88
8910318-12	1996	On the other hand, the substitution of Arg for Gly248 or Lys for Ser249 facilitates catalysis of thiosulfate in MST.	Thiosulfates	97-108	mercaptopyruvate sulfurtransferase	Rattus norvegicus	112-115
15045421-3	1996	The influence of the electrodeposition potential, the pH and the thiosulfate concentration on the stoichiometry of CdS and CdTe layers are discussed.	Thiosulfates	65-76	CDP-diacylglycerol synthase 1	Homo sapiens	115-118
9070219-1	1997	cDNA for the human rhodanese (thiosulfate; cyanide sulfurtransferase, EC 2.8.1.1) was cloned from a human fetal liver cDNA library.	Thiosulfates	30-41	thiosulfate sulfurtransferase	Cricetulus griseus	19-28
7665563-4	1995	When thiosulfate is present the GroEL-rhodanese complex can be concentrated to greater than 1 mg/ml rhodanese with little effect on the efficiency of renaturation.	Thiosulfates	5-16	heat shock protein family D (Hsp60) member 1	Homo sapiens	32-37
7514870-6	1994	Ferrous iron and the reducing agents cysteine and thiosulphate accelerate the rate of recovery of insulin secretion, and ferrous iron and thiosulphate stimulate the recovery of islet aconitase activity, suggesting that iron-sulphurcentre reconstitution may be involved in the recovery process.	Thiosulfates	50-62	insulin	Homo sapiens	98-105
7641082-1	1995	Rhodanese (thiosulfate:cyanide sulfurtransferase, E.C.	Thiosulfates	11-22	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	0-9
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Thiosulfates	94-105	tumor associated calcium signal transducer 2	Homo sapiens	62-69
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Thiosulfates	94-105	tumor associated calcium signal transducer 2	Homo sapiens	204-211
7958565-5	1994	Present studies suggest that there are advantages in using alternative sulfur donors, i.e., organic thiosulfonates in this rhodanese-containing resealed erythrocyte system, since these compounds have higher lipid solubility than inorganic thiosulfates and can readily penetrate the red blood cell membrane.	Thiosulfates	239-251	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	123-132
1647344-2	1991	Some in vitro studies were performed to elucidate the action of S-adenosyl-L-methionine (SAM) and thiosulphate on liver rhodanese, delta-amino-levulinic acid dehydratase (Al A-D) and cytochrome oxidase affected by cyanide in the experimental conditions.	Thiosulfates	98-110	aminolevulinate dehydratase	Homo sapiens	131-169
8096394-2	1993	The bacterial chaperonins, GroEL and GroES, along with the rhodanese substrate thiosulfate greatly enhance the specific enzymatic activity of the rhodanese polypeptide that is formed.	Thiosulfates	79-90	heat shock protein family D (Hsp60) member 1	Homo sapiens	27-32
8391509-5	1993	Thiosulfate sulfurtransferase (rhodanese) is shown to act as a cytochrome c reductase in the presence of thiosulfate and GSH, and again the generation of GSS- can be envisaged to explain this result.	Thiosulfates	105-116	thiosulfate sulfurtransferase	Homo sapiens	0-29
8391509-5	1993	Thiosulfate sulfurtransferase (rhodanese) is shown to act as a cytochrome c reductase in the presence of thiosulfate and GSH, and again the generation of GSS- can be envisaged to explain this result.	Thiosulfates	105-116	cytochrome c, somatic	Homo sapiens	63-75
1333420-1	1992	The aim of the experiments was to evaluate the effect of administration of cysteine, methionine, thiocystine, and thiosulphate upon the activity of mercaptopyruvate sulphurtransferase (MPST) and rhodanese in mouse liver.	Thiosulfates	114-126	mercaptopyruvate sulfurtransferase	Mus musculus	148-183
1333420-1	1992	The aim of the experiments was to evaluate the effect of administration of cysteine, methionine, thiocystine, and thiosulphate upon the activity of mercaptopyruvate sulphurtransferase (MPST) and rhodanese in mouse liver.	Thiosulfates	114-126	mercaptopyruvate sulfurtransferase	Mus musculus	185-189
1333420-3	1992	The MPST activity significantly increased after cysteine and to a lesser extent after thiocystine and thiosulphate.	Thiosulfates	102-114	mercaptopyruvate sulfurtransferase	Mus musculus	4-8
1667623-3	1991	The present method is about 70-fold more sensitive than the conventional method using cyanide and thiosulfate as substrates and correlates well (r = 0.997) with the conventional method in bovine liver rhodanese.	Thiosulfates	98-109	thiosulfate sulfurtransferase	Bos taurus	201-210
1816051-1	1991	The essential sulphydryl group of bovine liver rhodanese (thiosulphate: cyanide sulphurtrasferase, E.C.	Thiosulfates	58-70	thiosulfate sulfurtransferase	Bos taurus	47-56
1647344-6	1991	Cyanide and thiosulphate inhibited ALA-D activity when both compounds were present in the incubation or the preincubation mixture.	Thiosulfates	12-24	aminolevulinate dehydratase	Homo sapiens	35-40
1708376-9	1991	The amino acid sequence of the protein has similarity to bovine liver rhodanese, an enzyme that transfers the thiol group of thiosulfate to a thiophilic acceptor molecule, and a rhodaneselike protein of Saccharopolyspora erythraea.	Thiosulfates	125-136	thiosulfate sulfurtransferase	Bos taurus	70-79
1647344-2	1991	Some in vitro studies were performed to elucidate the action of S-adenosyl-L-methionine (SAM) and thiosulphate on liver rhodanese, delta-amino-levulinic acid dehydratase (Al A-D) and cytochrome oxidase affected by cyanide in the experimental conditions.	Thiosulfates	98-110	aminolevulinate dehydratase	Homo sapiens	171-177
34679660-0	2021	Saccharomyces cerevisiae Rhodanese RDL2 Uses the Arg Residue of the Active-Site Loop for Thiosulfate Decomposition.	Thiosulfates	89-100	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	35-39
2254590-4	1990	With thiosulfate as a substrate, the Km for rhodanese was 6.7 mM and the Vmax was 0.67 mumol thiocyanate min-1 mg-1 protein.	Thiosulfates	5-16	CD59 molecule (CD59 blood group)	Homo sapiens	105-115
2275748-1	1990	Rhodanese (thiosulfate: cyanide sulfurtransferase, EC 2.8.1.1.)	Thiosulfates	11-22	thiosulfate sulfurtransferase	Gallus gallus	0-9
2317511-8	1990	Sulfane sulfurtransferase, like rhodanese, catalyzes the transfer of sulfur from thiosulfate to cyanide via a persulfide intermediate, and displays remarkably similar kinetics in this process (Aird, B.A., Heinrikson, R.L.	Thiosulfates	81-92	thiosulfate sulfurtransferase	Bos taurus	32-41
24962324-0	2015	Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats.	Thiosulfates	28-39	angiotensinogen	Homo sapiens	81-95
34748908-5	2021	Rdl2 releases sulfane sulfur atoms (S0) from stable S0 carriers (thiosulfate and dialkyl polysulfide) to produce RSS.	Thiosulfates	65-76	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	0-4
34679660-5	2021	Herein, we report a 2.47 A resolution structure of RDL2 co-crystallized with thiosulfate (PDB entry: 6K6R).	Thiosulfates	77-88	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	51-55
34679660-11	2021	Thus, we propose that Arg can offer a hydrogen bond-rich, acidic-like microenvironment in RDL2 in which thiosulfate decomposes to release sulfane sulfur.	Thiosulfates	104-115	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	90-94
35394482-0	2022	Albumin as a prospective carrier of the nitrosyl iron complex with thiourea and thiosulfate ligands under aerobic conditions.	Thiosulfates	80-91	albumin	Homo sapiens	0-7
34108477-3	2021	Here we identified 191 phages derived from twelve environments that encoded 227 AMGs for oxidation of sulfur and thiosulfate (dsrA, dsrC/tusE, soxC, soxD and soxYZ).	Thiosulfates	113-124	phosphatidylinositol glycan anchor biosynthesis class P	Homo sapiens	132-136
34108477-3	2021	Here we identified 191 phages derived from twelve environments that encoded 227 AMGs for oxidation of sulfur and thiosulfate (dsrA, dsrC/tusE, soxC, soxD and soxYZ).	Thiosulfates	113-124	SRY-box transcription factor 6	Homo sapiens	149-153
34163455-5	2021	Thiosulfate gave the highest denitrification rates removing 10.94 mM NO3 - day-1 and 8.98 mM NO3 - day-1 by DS and GS, respectively.	Thiosulfates	0-11	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
34163455-5	2021	Thiosulfate gave the highest denitrification rates removing 10.94 mM NO3 - day-1 and 8.98 mM NO3 - day-1 by DS and GS, respectively.	Thiosulfates	0-11	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
2922757-9	1989	When thiosulfate was omitted, staining for rhodanese activity was still clearly identifiable in both liver and muscle sections with cyanide alone.	Thiosulfates	5-16	thiosulfate sulfurtransferase	Rattus norvegicus	43-52
35202787-4	2022	We show that all three quinones concentration-dependently catalyze the oxidization of H2S to polysulfides and thiosulfate in buffer with the potency CoQ0>CoQ1>CoQ10 and that CoQ0 specifically oxidizes H2S to per-polysulfides, H2S2,3,4.	Thiosulfates	110-121	decaprenyl diphosphate synthase subunit 1	Homo sapiens	154-158
2844672-7	1988	The ligand thiosulfate in equimolar concentrations to GTS had a statistically significant (P less than 0.01) inhibitory effect on AF"s blockade of O2- generation during the first 5 min of the interaction with the PMNs; thiomalate had no effect.	Thiosulfates	11-22	GTS	Homo sapiens	54-57
3165676-1	1988	Bovine liver rhodanese (thiosulfate:cyanide sulfurtransferase, EC 2.8.1.1) was prepared in dilute solutions and subjected to conditions that led to a time-dependent loss of enzyme activity.	Thiosulfates	24-35	thiosulfate sulfurtransferase	Bos taurus	13-22
6402020-4	1983	Rhodanese (thiosulfate: cyanide sulfurtransferase (EC 2.8.1.1) purified from bovine liver mitochondria was shown to restore, in the presence of thiosulfate, the activity of the partly inactivated NADH dehydrogenase.	Thiosulfates	11-22	thiosulfate sulfurtransferase	Bos taurus	0-9
3466649-8	1987	The substrate, thiosulfate, could reactivate the enzyme up to 70% in 1 h with ES as compared to 24 h with E. Tetrathionate modification of rhodanese could be correlated with the changes in intrinsic fluorescence and with the binding of the active site reporter 2-anilinonaphthalene-8-sulfonic acid (2,8-ANS).	Thiosulfates	15-26	thiosulfate sulfurtransferase	Bos taurus	139-148
6589161-0	1984	Differences in the binding of sulfate, selenate and thiosulfate ions to bovine liver rhodanese, and a description of a binding site for ammonium and sodium ions.	Thiosulfates	52-63	thiosulfate sulfurtransferase	Bos taurus	85-94
6589161-2	1984	The binding of sulfate, selenate and thiosulfate by the sulfur-transferase rhodanese (EC 2.8.1.1) in the crystalline state has been studied by X-ray analysis at resolutions between 0.23 nm and 0.4 nm.	Thiosulfates	37-48	thiosulfate sulfurtransferase	Bos taurus	75-84
6589161-7	1984	In the complex of sulfur-rhodanese with thiosulfate, the outer sulfur atom of the anion near the active centre points towards the extra sulfur atom which is bound as a persulfide to the S gamma of the essential Cys-247.	Thiosulfates	40-51	thiosulfate sulfurtransferase	Bos taurus	25-34
16346367-3	1983	Native but not mammalian cytochrome c was also reduced by the enzyme in the presence of thiosulfate.	Thiosulfates	88-99	cytochrome c, somatic	Homo sapiens	25-37
6402020-4	1983	Rhodanese (thiosulfate: cyanide sulfurtransferase (EC 2.8.1.1) purified from bovine liver mitochondria was shown to restore, in the presence of thiosulfate, the activity of the partly inactivated NADH dehydrogenase.	Thiosulfates	144-155	thiosulfate sulfurtransferase	Bos taurus	0-9
6402020-6	1983	Rhodanese-mediated sulfide transfer was directly demonstrated when the reactivation of NADH dehydrogenase was performed in the presence of radioactive thiosulfate (labeled in the outer sulfur) and the 35S-loaded flavoprotein was re-isolated by gel filtration chromatography.	Thiosulfates	151-162	thiosulfate sulfurtransferase	Bos taurus	0-9
1213990-3	1975	Kinetic studies revealed that Fraction I rat liver rhodanese catalyzes thiocyanate formation from thiosulfate and cyanide by a double displacement mechanism.	Thiosulfates	98-109	thiosulfate sulfurtransferase	Rattus norvegicus	51-60
6284218-5	1982	(4) Reducing equivalents from thiosulfate appear to enter the respiratory chain at the cytochrome c level; however, studies in cell-free extracts were limited due to a loss in respiratory activity with thiosulfate as a substrate upon cell disruption.	Thiosulfates	30-41	cytochrome c, somatic	Homo sapiens	87-99
18962947-2	1981	Cyanide masking and selective demasking of zinc can be used to deal with the interference of many metal ions, cadmium can be masked with semithiocarbazide, and thiosulphate can be used for masking Hg(II), Pd(II) and Os(VIII).	Thiosulfates	160-172	cytochrome c oxidase subunit 8A	Homo sapiens	219-223
986188-5	1976	A thiosulfate reduction activity of rhodanese was also found using dithiothreitol as reductant.	Thiosulfates	2-13	thiosulfate sulfurtransferase	Bos taurus	36-45
33922196-5	2021	Although thiosulfate was converted to sulfite and H2S by the mitochondrial rhodanese Rdl1, its toxicity was not due to H2S as the rdl1-deletion mutant that produced significantly less H2S was more sensitive to thiosulfate than the wild type.	Thiosulfates	9-20	thiosulfate sulfurtransferase RDL1	Saccharomyces cerevisiae S288C	85-89
13313183-2	1956	The relation between the apparent volume of distribution of thiosulfate and the volume of distribution of insulin.	Thiosulfates	60-71	insulin	Homo sapiens	106-113
4727786-0	1973	Protective effect of thiosulfate and metabolic thiosulfate precursors against toxicity of nitrogen mustard (HN2).	Thiosulfates	21-32	MT-RNR2 like 2 (pseudogene)	Homo sapiens	108-111
4727786-0	1973	Protective effect of thiosulfate and metabolic thiosulfate precursors against toxicity of nitrogen mustard (HN2).	Thiosulfates	47-58	MT-RNR2 like 2 (pseudogene)	Homo sapiens	108-111
4349317-0	1973	A Novel function of cytochrome C (555, Chlorobium thiosulfatophilum) in oxidation of thiosulfate.	Thiosulfates	85-96	cytochrome c, somatic	Homo sapiens	20-32
6020561-2	1967	The enzyme system in one of the isolates (C-3) was constitutive, but in the other isolate (A-50) it was induced by thiosulfate or tetrathionate.	Thiosulfates	115-126	complement C3	Homo sapiens	42-45
6020561-3	1967	The apparent K(m) for oxygen for thiosulfate oxidation by A-50 was about 223 mum, but, for lactate oxidation by A-50 or thiosulfate oxidation by C-3, the apparent K(m) for oxygen was below 2 mm.	Thiosulfates	120-131	complement C3	Homo sapiens	145-148
6020561-6	1967	Extracts of induced A-50 reduced ferricyanide, endogenous cytochrome c, and mammalian cytochrome c in the presence of thiosulfate.	Thiosulfates	118-129	cytochrome c, somatic	Homo sapiens	58-70
13512735-0	1957	[Research on the behavior of thiosulfate & PAI renal function tests & on the histomorphological characteristics of the kidney in animals subjected to experimental thyroidectomy].	Thiosulfates	29-40	serpin family E member 1	Homo sapiens	47-50
33949526-7	2021	Therefore, thiosulfate could potentially have a similar chemoprotective effect against diimine fac-Re(CO)3 complexes as it has against cisplatin.	Thiosulfates	11-22	FA complementation group C	Homo sapiens	95-98
32157599-0	2020	Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients.	Thiosulfates	107-118	CIHL	Homo sapiens	130-160
31678147-0	2020	Influence of hemoglobin and albumin on the NO donation effect of tetranitrosyl iron complex with thiosulfate.	Thiosulfates	97-108	albumin	Homo sapiens	28-35
32275397-5	2020	Cu(II) and thiosulfate strongly increased silver release (up to 83% of total Ag) from Ag2S in the dark.	Thiosulfates	11-22	angiotensin II receptor type 1	Homo sapiens	86-90
31678147-1	2020	The effects of deoxyhemoglobin (Hb) and albumin on the NO-donor activity of the anionic tetranitrosyl iron complex with thiosulfate ligands (1) were studied for the first time.	Thiosulfates	120-131	albumin	Homo sapiens	40-47
31727914-8	2019	The assays showed Km values of 2.89 mM and 7.02 mM for thiosulfate and 3-mercaptopyruvate, respectively, indicating the protein has dual activity as TST and MST.	Thiosulfates	55-66	thiosulfate sulfurtransferase	Homo sapiens	149-152
31893496-3	2019	In the mitochondria, hydrogen sulfide is oxidized to sulfite, which is then converted to thiosulfate (sulfane sulfur-containing compound) by thiosulfate sulfurtransferase (rhodanese; TST).	Thiosulfates	89-100	thiosulfate sulfurtransferase	Rattus norvegicus	141-170
31893496-3	2019	In the mitochondria, hydrogen sulfide is oxidized to sulfite, which is then converted to thiosulfate (sulfane sulfur-containing compound) by thiosulfate sulfurtransferase (rhodanese; TST).	Thiosulfates	89-100	thiosulfate sulfurtransferase	Rattus norvegicus	183-186
30880290-8	2019	These results indicate that CRP plays a key role in the generation of H2S coupled to thiosulfate assimilation, whose molecular mechanisms remains to be elucidated.	Thiosulfates	85-96	catabolite gene activator protein	Escherichia coli	28-31
31356773-4	2019	Their transport properties and kinetic parameters demonstrate that UCP5 and UCP6 transport inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and (only UCP5) glutamate and tricarboxylates.	Thiosulfates	127-138	solute carrier family 25 member 14	Homo sapiens	67-71
31408267-2	2019	We describe the one-pot total synthesis of human thiosulfate:glutathione sulfurtransferase (TSTD1).	Thiosulfates	49-60	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	92-97
31356773-7	2019	The transport affinities of UCP5 and UCP6 were higher for sulfate and thiosulfate than for any other substrate, whereas the specific activity of UCP5 was much higher than that of UCP6.	Thiosulfates	70-81	solute carrier family 25 member 14	Homo sapiens	28-32
31356773-8	2019	It is proposed that a main physiological role of UCP5 and UCP6 is to catalyze the export of sulfite and thiosulfate (the H2S degradation products) from the mitochondria, thereby modulating the level of the important signal molecule H2S.	Thiosulfates	104-115	solute carrier family 25 member 14	Homo sapiens	49-53
30341787-7	2019	Urinary homolanthionine and thiosulfate in CBSD were increased significantly 1.9 and 3 times suggesting higher hydrogen sulfide synthesis by gamma-cystathionase and detoxification respectively.	Thiosulfates	28-39	cystathionine gamma-lyase	Homo sapiens	141-160
30349987-3	2019	Patients with pathogenic mutations in ETHE1 have markedly increased thiosulfate, which is a reliable index of H2S levels.	Thiosulfates	68-79	ETHE1 persulfide dioxygenase	Homo sapiens	38-43
29348167-5	2018	The relatively unstudied human thiosulfate sulfurtransferase-like domain-containing 1 (TSTD1) protein, a single-domain cytoplasmic sulfurtransferase, was also postulated to play a role in the sulfide oxidation pathway using thiosulfate to form glutathione persulfide, for subsequent processing in the mitochondrial matrix.	Thiosulfates	31-42	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	87-92
30141069-3	2018	Recently, we have reported that many heterotrophic bacteria can use sulfide:quinone oxidoreductase and persulfide dioxygenase to oxidize H2S to thiosulfate and sulfite.	Thiosulfates	144-155	crystallin zeta	Homo sapiens	76-98
30472982-7	2018	We also found that anemic CKD patients requiring exogenous EPO exhibited lower urinary thiosulfate levels compared to non-anemic CKD patients of similar CKD classification.	Thiosulfates	87-98	erythropoietin	Homo sapiens	59-62
30219948-1	2018	nov., a thiosulfate-oxidizing and arsenate-reducing organism isolated from Little Hot Creek in the Long Valley Caldera, California.	Thiosulfates	8-19	cellular communication network factor 3	Homo sapiens	0-3
30056533-5	2018	In vivo findings showed that thiosulfate administration decreased the activities of CK and citrate synthase, and increased the activity of catalase 30 min after administration.	Thiosulfates	29-40	citrate synthase	Rattus norvegicus	91-107
29508061-4	2018	In the presence of elevated levels of H2S and thiosulfate, the sulfhydryl groups of p53 protein as well as Bcl-2 protein could be modified via HBITC-induced S-sulfuration or by oxidative stress.	Thiosulfates	46-57	tumor protein p53	Homo sapiens	84-87
29508061-4	2018	In the presence of elevated levels of H2S and thiosulfate, the sulfhydryl groups of p53 protein as well as Bcl-2 protein could be modified via HBITC-induced S-sulfuration or by oxidative stress.	Thiosulfates	46-57	BCL2 apoptosis regulator	Homo sapiens	107-112
30217845-3	2018	S. cerevisiae absorbed thiosulfate into the cell through two sulfate permeases, Sul1 and Sul2.	Thiosulfates	23-34	sulfate permease	Saccharomyces cerevisiae S288C	80-84
30217845-3	2018	S. cerevisiae absorbed thiosulfate into the cell through two sulfate permeases, Sul1 and Sul2.	Thiosulfates	23-34	sulfate permease	Saccharomyces cerevisiae S288C	89-93
30217845-4	2018	Two rhodaneses, Rdl1 and Rdl2, converted thiosulfate to a persulfide and sulfite.	Thiosulfates	41-52	thiosulfate sulfurtransferase RDL1	Saccharomyces cerevisiae S288C	16-20
30217845-4	2018	Two rhodaneses, Rdl1 and Rdl2, converted thiosulfate to a persulfide and sulfite.	Thiosulfates	41-52	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	25-29
29906753-2	2018	In this study, the ratio of S2O32--S/NO3--N and pH are confirmed to be two key factors affecting the thiosulfate-driven denitratation activity and nitrite accumulation.	Thiosulfates	101-112	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
29906753-7	2018	At HRT of 30 min, the NO3- removal efficiency could achieve above 90% with the nitrate-to-nitrite transformation ratio of 0.8, implying the great potential to apply the thiosulfate-driven denitratation & anammox system for BNR with minimal sludge production.	Thiosulfates	169-180	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
29348167-8	2018	Kinetic studies with a combination of sulfur donors and acceptors reveal that TSTD1 exhibits a low Km for thioredoxin as a sulfane sulfur acceptor and that it utilizes thiosulfate inefficiently as a sulfur donor.	Thiosulfates	168-179	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	78-83
28864655-2	2017	Some bacteria with sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) can oxidize self-produced sulfide to sulfite and thiosulfate, but other bacteria without these enzymes release sulfide into the medium, from which H2S can volatilize into the gas phase.	Thiosulfates	138-149	H16_RS23915	Ralstonia eutropha H16	27-49
28777380-1	2017	Sulfide (H2S, HS- and S2-) oxidation to sulfite and thiosulfate by heterotrophic bacteria, using sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO), has recently been reported as a possible detoxification mechanism for sulfide at high levels.	Thiosulfates	52-63	quinone oxidoreductase	Pseudomonas aeruginosa PAO1	105-127
28550177-8	2017	In addition, treatment with thiosulfate also diminished VEGF-induced cystathionine-gamma-lyase expression and reduced VEGF-induced HUVEC proliferation under both normoxic and hypoxic conditions.	Thiosulfates	28-39	vascular endothelial growth factor A	Homo sapiens	56-60
28550177-8	2017	In addition, treatment with thiosulfate also diminished VEGF-induced cystathionine-gamma-lyase expression and reduced VEGF-induced HUVEC proliferation under both normoxic and hypoxic conditions.	Thiosulfates	28-39	vascular endothelial growth factor A	Homo sapiens	118-122
28550177-11	2017	Moreover, our findings also reveal that thiosulfate surprisingly inhibits VEGF-dependent endothelial cell proliferation associated with a reduction in cystathionine-gamma-lyase protein levels.	Thiosulfates	40-51	vascular endothelial growth factor A	Homo sapiens	74-78
28632164-0	2017	The Role of Hemoproteins: Hemoglobin, Myoglobin and Neuroglobin in Endogenous Thiosulfate Production Processes.	Thiosulfates	78-89	neuroglobin	Homo sapiens	52-63
28632164-4	2017	In this review, we discuss the current state of knowledge on the interactions between hydrogen sulfide and hemoglobin, myoglobin and neuroglobin and postulate that thiosulfate is a metabolically important product of this processes.	Thiosulfates	164-175	myoglobin	Homo sapiens	119-128
28632164-4	2017	In this review, we discuss the current state of knowledge on the interactions between hydrogen sulfide and hemoglobin, myoglobin and neuroglobin and postulate that thiosulfate is a metabolically important product of this processes.	Thiosulfates	164-175	neuroglobin	Homo sapiens	133-144
28246171-7	2017	Ferric neuroglobin is slowly reduced by H2S and catalyzes its inefficient oxidative conversion to thiosulfate.	Thiosulfates	98-109	neuroglobin	Homo sapiens	7-18
27125215-2	2016	We report here the functional characterization of human SLC26A1, a 4,4"-diisothiocyanato-2,2"-stilbenedisulfonic acid (DIDS)-sensitive, electroneutral sodium-independent anion exchanger transporting sulfate, oxalate, bicarbonate, thiosulfate, and (with divergent properties) chloride.	Thiosulfates	230-241	solute carrier family 26 member 1	Homo sapiens	56-63
27038311-1	2017	3-mercaptopyruvate sulfurtransferase (3-MST) was a novel hydrogen sulfide (H2S)-synthesizing enzyme that may be involved in cyanide degradation and in thiosulfate biosynthesis.	Thiosulfates	151-162	mercaptopyruvate sulfurtransferase	Mus musculus	0-36
27038311-1	2017	3-mercaptopyruvate sulfurtransferase (3-MST) was a novel hydrogen sulfide (H2S)-synthesizing enzyme that may be involved in cyanide degradation and in thiosulfate biosynthesis.	Thiosulfates	151-162	mercaptopyruvate sulfurtransferase	Mus musculus	38-43
28735401-12	2017	Sulfite-generating ST activity is determined by colorimetric detection of SCN- formation at 460 nm as the red Fe(SCN)3 complex from cyanide and thiosulfate using acidic iron reagent.	Thiosulfates	144-155	HCLS1 associated protein X-1	Homo sapiens	113-118
27523630-1	2016	Patients affected by sulfite oxidase (SO) deficiency present severe seizures early in infancy and progressive neurological damage, as well as tissue accumulation of sulfite, thiosulfate and S-sulfocysteine.	Thiosulfates	174-185	sulfite oxidase	Rattus norvegicus	21-36
27523630-1	2016	Patients affected by sulfite oxidase (SO) deficiency present severe seizures early in infancy and progressive neurological damage, as well as tissue accumulation of sulfite, thiosulfate and S-sulfocysteine.	Thiosulfates	174-185	sulfite oxidase	Rattus norvegicus	38-40
27591534-6	2016	On the measurements of serum thiosulfate by our developed method, a thiosulfate concentration as 57.5muM was detected clearly in the H2S poisoning case comparing to the non poisoning case in which only a trace amount of thiosulfate was observed.	Thiosulfates	68-79	latexin	Homo sapiens	101-104
27105581-6	2016	Sulfite is then converted to thiosulfate by addition of a second persulfide group by sulfurtransferase 1.	Thiosulfates	29-40	mercaptopyruvate sulfurtransferase 1	Arabidopsis thaliana	85-104
26140942-6	2015	AtAPC2 and AtAPC3 also had the ability to transport sulfate and thiosulfate.	Thiosulfates	64-75	anaphase-promoting complex/cyclosome 2	Arabidopsis thaliana	0-6
26917598-1	2016	Ethylmalonic encephalopathy is a fatal, rapidly progressive mitochondrial disorder caused by ETHE1 mutations, whose peculiar clinical and biochemical features are due to the toxic accumulation of hydrogen sulphide and of its metabolites, including thiosulphate.	Thiosulfates	248-260	ETHE1 persulfide dioxygenase	Homo sapiens	93-98
26538444-0	2016	Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis.	Thiosulfates	12-23	prestin	Drosophila melanogaster	56-64
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Thiosulfates	13-24	prestin	Drosophila melanogaster	51-59
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Thiosulfates	13-24	prestin	Drosophila melanogaster	191-199
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Thiosulfates	120-131	prestin	Drosophila melanogaster	51-59
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Thiosulfates	120-131	prestin	Drosophila melanogaster	191-199
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Thiosulfates	120-131	prestin	Drosophila melanogaster	51-59
26538444-8	2016	Furthermore, thiosulfate has a higher affinity for dPrestin and mSlc26a6 compared with oxalate These data indicate that thiosulfate"s ability to act as a competitive inhibitor of oxalate via dPrestin, can explain the decrease in CaOx crystallization seen in the presence of thiosulfate, but not sulfate.	Thiosulfates	120-131	prestin	Drosophila melanogaster	191-199
27591534-6	2016	On the measurements of serum thiosulfate by our developed method, a thiosulfate concentration as 57.5muM was detected clearly in the H2S poisoning case comparing to the non poisoning case in which only a trace amount of thiosulfate was observed.	Thiosulfates	29-40	latexin	Homo sapiens	101-104
27591534-6	2016	On the measurements of serum thiosulfate by our developed method, a thiosulfate concentration as 57.5muM was detected clearly in the H2S poisoning case comparing to the non poisoning case in which only a trace amount of thiosulfate was observed.	Thiosulfates	68-79	latexin	Homo sapiens	101-104
26546573-8	2015	Protective effects of thiosulfate were associated with inhibition of caspase-3 activity by persulfidation at Cys163 in caspase-3.	Thiosulfates	22-33	caspase 3	Homo sapiens	69-78
26546573-8	2015	Protective effects of thiosulfate were associated with inhibition of caspase-3 activity by persulfidation at Cys163 in caspase-3.	Thiosulfates	22-33	caspase 3	Homo sapiens	119-128
26546573-9	2015	We discovered that an SLC13 family protein, sodium sulfate cotransporter 2 (SLC13A4, NaS-2), facilitates transport of thiosulfate, but not sulfide, across the cell membrane, regulating intracellular concentrations and thus mediating cytoprotective effects of Na2S and STS.	Thiosulfates	118-129	solute carrier family 13 member 4	Homo sapiens	76-83
26546573-9	2015	We discovered that an SLC13 family protein, sodium sulfate cotransporter 2 (SLC13A4, NaS-2), facilitates transport of thiosulfate, but not sulfide, across the cell membrane, regulating intracellular concentrations and thus mediating cytoprotective effects of Na2S and STS.	Thiosulfates	118-129	solute carrier family 13 member 4	Homo sapiens	85-90
26546573-10	2015	CONCLUSIONS: The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3.	Thiosulfates	59-70	solute carrier family 13 member 4	Homo sapiens	115-120
26546573-10	2015	CONCLUSIONS: The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3.	Thiosulfates	59-70	caspase 3	Homo sapiens	176-185
26140942-6	2015	AtAPC2 and AtAPC3 also had the ability to transport sulfate and thiosulfate.	Thiosulfates	64-75	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	11-17
26269602-2	2015	Rhodanese catalyzes the transfer of sulfane sulfur from glutathione persulfide (GSSH) to sulfite generating thiosulfate and from thiosulfate to cyanide generating thiocyanate.	Thiosulfates	108-119	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	0-9
26269602-2	2015	Rhodanese catalyzes the transfer of sulfane sulfur from glutathione persulfide (GSSH) to sulfite generating thiosulfate and from thiosulfate to cyanide generating thiocyanate.	Thiosulfates	129-140	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	0-9
26269602-8	2015	All three rhodanese forms preferentially catalyze sulfur transfer from GSSH to sulfite, generating thiosulfate and glutathione.	Thiosulfates	99-110	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	10-19
25688092-5	2015	Furthermore, we have discovered the locus of sulfide oxidation in RBCs and describe a new role for an old protein, hemoglobin, which in the ferric or methemoglobin state binds H2S and oxidizes it to a mixture of thiosulfate and hydropolysulfides.	Thiosulfates	212-223	hemoglobin subunit gamma 2	Homo sapiens	150-163
25777939-1	2015	Sulfite oxidase (SOX) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation and high urinary excretion of sulfite and thiosulfate.	Thiosulfates	166-177	sulfite oxidase	Rattus norvegicus	0-15
25777939-1	2015	Sulfite oxidase (SOX) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation and high urinary excretion of sulfite and thiosulfate.	Thiosulfates	166-177	sulfite oxidase	Rattus norvegicus	17-20
25777939-5	2015	We also observed that thiosulfate inhibited glutamine synthetase (GS) activity.	Thiosulfates	22-33	glutamate-ammonia ligase	Rattus norvegicus	44-64
26177047-6	2015	In contrast, CstB oxidizes major cellular low molecular weight (LMW) persulfide substrates from S. aureus, coenzyme A persulfide (CoASSH) and bacillithiol persulfide (BSSH), directly to generate thiosulfate (TS) and reduced thiols, thereby avoiding the cellular toxicity of sulfite.	Thiosulfates	195-206	cystatin B	Homo sapiens	13-17
24793416-1	2014	Sulfite oxidase (SO) deficiency is biochemically characterized by the accumulation of sulfite, thiosulfate and S-sulfocysteine in tissues and biological fluids of the affected patients.	Thiosulfates	95-106	sulfite oxidase	Homo sapiens	0-15
25725525-1	2015	A cystine-catabolizing enzyme, 3-mercaptopyruvate sulfurtransferase catalyzes the trans-sulfuration reaction of mercaptopyruvate or thiosulfate to thiol-containing compounds or cyanide.	Thiosulfates	132-143	mercaptopyruvate sulfurtransferase	Homo sapiens	31-67
24793416-1	2014	Sulfite oxidase (SO) deficiency is biochemically characterized by the accumulation of sulfite, thiosulfate and S-sulfocysteine in tissues and biological fluids of the affected patients.	Thiosulfates	95-106	sulfite oxidase	Homo sapiens	17-19
23758073-10	2014	INNOVATION: These results suggest that inhibition of CSE or administration of STS prevents acute inflammatory liver failure by augmenting thiosulfate levels and upregulating antioxidant and anti-apoptotic defense in the liver.	Thiosulfates	138-149	cystathionase (cystathionine gamma-lyase)	Mus musculus	53-56
24987017-5	2014	As a consequence of SiR impairment, the levels of sulfite, sulfate, and thiosulfate were higher and glutathione levels were lower compared with the wild type.	Thiosulfates	72-83	sulfite reductase	Solanum lycopersicum	20-23
24981631-2	2014	SQOR"s inability to produce the glutathione persulfide (GSS(-)) substrate for sulfur dioxygenase (SDO) suggested that a thiosulfate:glutathione sulfurtransferase (TST) was required to provide the missing link between the SQOR and SDO reactions.	Thiosulfates	120-131	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	163-166
24981631-5	2014	Recombinant TSTD1 and RDL1 catalyze a predicted thiosulfate-dependent conversion of glutathione to GSS(-).	Thiosulfates	48-59	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	12-17
24981631-5	2014	Recombinant TSTD1 and RDL1 catalyze a predicted thiosulfate-dependent conversion of glutathione to GSS(-).	Thiosulfates	48-59	thiosulfate sulfurtransferase RDL1	Saccharomyces cerevisiae S288C	22-26
24981631-10	2014	The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor.	Thiosulfates	144-155	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	66-69
24511127-9	2014	Thiosulfate beneficially associated with eGFR, serum acidity, high-sensitivity C-reactive protein, and N-terminal probrain natriuretic peptide (all P<=0.001).	Thiosulfates	0-11	epidermal growth factor receptor	Homo sapiens	41-45
24511127-9	2014	Thiosulfate beneficially associated with eGFR, serum acidity, high-sensitivity C-reactive protein, and N-terminal probrain natriuretic peptide (all P<=0.001).	Thiosulfates	0-11	C-reactive protein	Homo sapiens	79-97
25079642-9	2014	Electrochemical methods revealed that HA could enhance the electrocatalytic current of both in vitro and in vivo Cyt c towards oxygen and thiosulfate, suggesting enhanced EET.	Thiosulfates	138-149	cytochrome c, somatic	Equus caballus	113-118
23758073-11	2014	CONCLUSION: Congenital deficiency or chemical inhibition of CSE increases thiosulfate levels in the liver and prevents ALF at least in part by augmentation of antioxidant and anti-apoptotic mechanisms.	Thiosulfates	74-85	cystathionase (cystathionine gamma-lyase)	Mus musculus	60-63
22903887-4	2012	Here, we show that AAV2/8-mediated, ETHE1-gene transfer to the liver of a genetically, metabolically and clinically faithful EE mouse model resulted in full restoration of SDO activity, correction of plasma thiosulfate, a biomarker reflecting the accumulation of H(2)S, and spectacular clinical improvement.	Thiosulfates	207-218	ethylmalonic encephalopathy 1	Mus musculus	36-41
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Thiosulfates	124-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
23999614-2	2013	We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes.	Thiosulfates	124-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	243-249
23350603-3	2013	CDO(-/-) mice had elevated urinary excretion of thiosulfate, high tissue and serum cystathionine and lanthionine levels, and evidence of inhibition and destabilization of cytochrome c oxidase, which is consistent with excess production of H2S/HS(-).	Thiosulfates	48-59	cysteine dioxygenase 1, cytosolic	Mus musculus	0-3
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Thiosulfates	113-124	solute carrier family 13 member 1	Homo sapiens	35-39
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Thiosulfates	113-124	solute carrier family 13 member 1	Homo sapiens	41-48
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Thiosulfates	113-124	solute carrier family 13 member 4	Homo sapiens	54-58
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Thiosulfates	113-124	solute carrier family 13 member 4	Homo sapiens	60-67
18805995-3	2008	Some of the isolates contained genes for thiosulfate oxidation (soxB) and anoxygenic photosynthesis (pufM), possibly enabling the strains to better compete in these sulfur-rich environments subject to long periods of illumination in the Arctic summer.	Thiosulfates	41-52	SRY-box transcription factor 3	Homo sapiens	64-68
20135153-2	2011	The best characterized Str is bovine rhodanese (EC 2.8.1.1) which catalyses in vitro the transfer of a sulfane sulfur atom from thiosulfate to cyanide, leading to the formation of sulfite and thiocyanate.	Thiosulfates	128-139	thiosulfate sulfurtransferase	Bos taurus	37-46
19046683-7	2009	Arsenate (As(V)) was reduced to As(III) with thiosulfate, and then the total inorganic As was quantified as As(III).	Thiosulfates	45-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
22852582-10	2012	We propose that sulfite is the physiological acceptor of the sulfane sulfur and that the SQOR reaction is the predominant source of the thiosulfate produced during H(2)S oxidation by mammalian tissues.	Thiosulfates	136-147	sulfide quinone oxidoreductase	Homo sapiens	89-93
20143161-4	2010	Some green sulfur bacteria oxidize thiosulfate by the multienzyme system called either the TOMES (thiosulfate oxidizing multi-enzyme system) or Sox (sulfur oxidizing system) composed of the three periplasmic proteins: SoxB, SoxYZ, and SoxAXK with a soluble small molecule cytochrome c as the electron acceptor.	Thiosulfates	35-46	SRY-box transcription factor 3	Homo sapiens	218-222
20143161-4	2010	Some green sulfur bacteria oxidize thiosulfate by the multienzyme system called either the TOMES (thiosulfate oxidizing multi-enzyme system) or Sox (sulfur oxidizing system) composed of the three periplasmic proteins: SoxB, SoxYZ, and SoxAXK with a soluble small molecule cytochrome c as the electron acceptor.	Thiosulfates	35-46	cytochrome c, somatic	Homo sapiens	272-284
19685866-0	2009	Microsolvation of thiosulfuric acid and its tautomeric anions [HSSO(3)](-) and [SSO(2)(OH)](-) studied by B3LYP-PCM and G3X(MP2) calculations.	Thiosulfates	18-35	tryptase pseudogene 1	Homo sapiens	124-127
19542325-0	2009	Anaerobic respiration of elemental sulfur and thiosulfate by Shewanella oneidensis MR-1 requires psrA, a homolog of the phsA gene of Salmonella enterica serovar typhimurium LT2.	Thiosulfates	46-57	TetR/AcrR family transcriptional regulator	Shewanella oneidensis MR-1	97-101
19542325-0	2009	Anaerobic respiration of elemental sulfur and thiosulfate by Shewanella oneidensis MR-1 requires psrA, a homolog of the phsA gene of Salmonella enterica serovar typhimurium LT2.	Thiosulfates	46-57	thiosulfate reductase PhsA	Shewanella oneidensis MR-1	120-124
19136963-6	2009	We found that thiosulfate was excreted in massive amounts in urine of both Ethe1(-/-) mice and humans with ethylmalonic encephalopathy.	Thiosulfates	14-25	ethylmalonic encephalopathy 1	Mus musculus	75-80
19136963-7	2009	High thiosulfate and sulfide concentrations were present in Ethe1(-/-) mouse tissues.	Thiosulfates	5-16	ethylmalonic encephalopathy 1	Mus musculus	60-65
18650437-4	2008	The low activity of MOCS3-RLD with thiosulfate as sulfur donor and detailed mutagenesis studies showed that thiosulfate is most likely not the physiological sulfur source for Moco biosynthesis in eukaryotes.	Thiosulfates	35-46	molybdenum cofactor synthesis 3	Homo sapiens	20-25
18650437-4	2008	The low activity of MOCS3-RLD with thiosulfate as sulfur donor and detailed mutagenesis studies showed that thiosulfate is most likely not the physiological sulfur source for Moco biosynthesis in eukaryotes.	Thiosulfates	108-119	molybdenum cofactor synthesis 3	Homo sapiens	20-25
18494801-5	2008	The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate.	Thiosulfates	173-184	crystallin zeta	Homo sapiens	107-129
18491921-4	2008	We demonstrate that the C-terminal domain of Uba4, like MOCS3, has rhodanese activity and is able to transfer the sulfur from thiosulfate to cyanide in vitro.	Thiosulfates	126-137	molybdenum cofactor synthesis 3	Homo sapiens	45-49
18491921-4	2008	We demonstrate that the C-terminal domain of Uba4, like MOCS3, has rhodanese activity and is able to transfer the sulfur from thiosulfate to cyanide in vitro.	Thiosulfates	126-137	molybdenum cofactor synthesis 3	Homo sapiens	56-61