PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29182689-2	2017	We have used solvothermal reactions of a bifunctional p-bitmb ligand with [Ru(arene)X2]2 in CH2Cl2 or CH2Br2 to generate the novel mononuclear metallamacrocyclic [RuX(arene)L2CH2]X3 complexes 1-3 (1, arene = p-cym, X = Cl; 2, arene = bip, X = Cl; 3, arene = p-cym, X = Br), which were characterized by various techniques.	Methylene Chloride	92-98	growth differentiation factor 10	Homo sapiens	234-237
29182692-3	2017	Through careful analysis, we find that the central chloride arises from a generally ignored but nonetheless existing reaction between CH2Cl2 and NEt3, which is well recognized as the Menshutkin reaction.	Methylene Chloride	134-140	tetraspanin 2	Homo sapiens	145-149
29083010-3	2017	In CH2Cl2, the anthracene units in aip, 1 and 2 underwent photo-oxidation upon irradiation with 365 nm light, forming species aip-O, 1-O and 2-O, respectively.	Methylene Chloride	3-9	ADP ribosylation factor like GTPase 6 interacting protein 1	Homo sapiens	35-47
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	Methylene Chloride	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-56
29064238-4	2017	Two irreversible reductions are observed for (TpYPP)CoII and butano(TpYPP)CoII in CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate; the first leads to the formation of a highly reactive cobalt(I) porphyrin, which can then rapidly react with a solvent to give a CoIIICH2Cl as the product.	Methylene Chloride	82-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78
29101851-5	2017	The explicit solvents of dichloromethane (DCM) and water present a disparity of OH bond dissociation enthalpy and free energy (BDE and BDFE).	Methylene Chloride	25-40	homeobox D13	Homo sapiens	127-130
28875202-4	2017	The Au(PPh3)2Cl precursor could be directly reduced by NaBH4 (0.25 molar equivalent) in a dichloromethane solution; this produced Au8 clusters with a 35% reaction yield.	Methylene Chloride	90-105	protein phosphatase 4 catalytic subunit	Homo sapiens	7-11
28793182-2	2017	Herein, we demonstrate the potential of Cu(CF3 SO3 ) for the construction of the novel 2D polymer [{Cp*Fe(mu4 ,eta5:1:1:1 -P5 )}{Cu(CF3 SO3 )}]n (2) and the unprecedented nanosphere (CH2 Cl2 )1.4 @[{CpBn Fe(eta5 -P5 )}12 {Cu(CF3 SO3 )}19.6 ] (3).	Methylene Chloride	183-190	adaptor related protein complex 4 subunit mu 1	Homo sapiens	106-109
28771358-1	2017	The dichloromethane extract of the roots of Jatropha dioica afforded riolozatrione (1) and a C-6 epimer of riolozatrione, 6-epi-riolozatrione (2), as a new structure and only the second reported riolozane diterpenoid.	Methylene Chloride	4-19	complement C6	Homo sapiens	93-96
28835957-3	2017	This work was underpinned by detailed mechanistic studies examining the hydrogenation of 1 : 1 mixtures of 2 and bipy in CH2Cl2, which proceeds with disparate rates to afford [M(bipy)H2(PPh3)2][BArF4] (M = Rh, 4a[BArF4], t = 18 h @ 50  C; Ir, 4b[BArF4], t < 5 min @ RT) in CH2Cl2 (1 atm H2).	Methylene Chloride	121-127	caveolin 1	Homo sapiens	186-190
28835957-3	2017	This work was underpinned by detailed mechanistic studies examining the hydrogenation of 1 : 1 mixtures of 2 and bipy in CH2Cl2, which proceeds with disparate rates to afford [M(bipy)H2(PPh3)2][BArF4] (M = Rh, 4a[BArF4], t = 18 h @ 50  C; Ir, 4b[BArF4], t < 5 min @ RT) in CH2Cl2 (1 atm H2).	Methylene Chloride	276-282	caveolin 1	Homo sapiens	186-190
28713973-0	2017	A dichloromethane fraction of Triticum aestivum sprouts reduces allergic immune response through inhibiting Th2 differentiation in ovalbumin-immunized mice.	Methylene Chloride	2-17	heart and neural crest derivatives expressed 2	Mus musculus	108-111
28713973-2	2017	The present study aimed to determine whether a dichloromethane fraction isolated from Triticum aestivum sprouts (TDF) suppressed the allergic immune response in ovalbumin (OVA)-sensitized mice.	Methylene Chloride	47-62	sex determining region of Chr Y	Mus musculus	113-116
28671842-3	2017	Crystal-to-crystal transformations of CPs 1-6 were reversible under heat or in an appropriate solvent (acetonitrile, dichloromethane, chloroform, or benzene).	Methylene Chloride	117-132	carbamoyl-phosphate synthase 1	Homo sapiens	38-43
28570936-4	2017	UPA was extracted from human serum using liquid-liquid extraction with a combination of hexane and dichloromethane.	Methylene Chloride	99-114	plasminogen activator, urokinase	Homo sapiens	0-3
31457662-2	2017	In the presence of PPh3 or CO, these ruthenium complexes reacted with NH4PF6 in CH2Cl2 or CH3OH to give a series of ionic products 5-9.	Methylene Chloride	80-86	protein phosphatase 4 catalytic subunit	Homo sapiens	19-23
28664957-1	2017	Four-coordinate, monoradical-containing Co(iii) complexes participated in the non-innocent ligand driven homolytic cleavage of S-S and Se-Se bonds and catalyzed the conversion of RNCO (R = phenyl and naphthyl) to the corresponding urea derivatives (TON 480) in dry CH2Cl2 under sunlight stimulus.	Methylene Chloride	265-271	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	40-47
28414431-1	2017	Orange Tp*WSCl2 has been synthesized from the reactions of Tp*WOCl2 with boron sulfide in refluxing toluene or Tp*WS2Cl with PPh3 in dichloromethane at room temperature.	Methylene Chloride	133-148	caveolin 1	Homo sapiens	125-129
28501008-0	2017	Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl4-induced oxidative damage in vitro and in vivo with the involvement of Nrf2.	Methylene Chloride	24-39	C-C motif chemokine ligand 4	Homo sapiens	120-124
27896817-7	2017	In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes responsible for the genotoxic effects of 1,2-DCP and DCM, were analyzed by quantitative polymerase chain reaction and western blotting.	Methylene Chloride	133-136	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	44-50
27896817-7	2017	In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes responsible for the genotoxic effects of 1,2-DCP and DCM, were analyzed by quantitative polymerase chain reaction and western blotting.	Methylene Chloride	133-136	glutathione S-transferase theta 1	Rattus norvegicus	55-60
28240873-1	2017	We carried out time-resolved infrared (TR-IR) and emission lifetime measurements on a Re(I) carbonyl complex having an N-heterocyclic carbene ligand, namely, fac-[Re(CO)3(PyImPh)Br], under photochemically reactive (in solution in acetonitrile) and nonreactive (in solution in dichloromethane) conditions to investigate the mechanism of photochemical ligand substitution reactions.	Methylene Chloride	276-291	FA complementation group C	Homo sapiens	158-161
28393959-2	2017	The aryl-halogen bond hydroxylation and subsequent N,O-acetalization on CH2Cl2 are enabled under catalytic conditions which allows the generation of C(sp2)-O, C(sp3)-O and C(sp3)-N bonds to give the target products.	Methylene Chloride	72-78	Sp2 transcription factor	Homo sapiens	149-154
28293393-10	2017	DNA fragmentation, increased in the level of Bax and cleavage of PARP protein all showed the induction of apoptosis with CH2Cl2 extract after 48 hr contact with cells.	Methylene Chloride	121-127	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
28293393-10	2017	DNA fragmentation, increased in the level of Bax and cleavage of PARP protein all showed the induction of apoptosis with CH2Cl2 extract after 48 hr contact with cells.	Methylene Chloride	121-127	collagen type XI alpha 2 chain	Homo sapiens	65-69
28100882-1	2017	A fractionation methodology of fat, oil and grease (FOG) deposits was developed based on the insolubility of fatty acid salts in dichloromethane (DCM) and the relatively high solubility of fatty acids and triglycerides in DCM.	Methylene Chloride	129-144	FAT atypical cadherin 1	Homo sapiens	31-50
28146411-4	2017	In addition, SH extract and MC fraction not only scavenged reactive oxygen species efficiently but also caused nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 and subsequently significant induction of antioxidant enzymes such as NAD(P)H:quinone oxidoreductase, heme oxygenase 1 (HO-1), and glutathione reductase.	Methylene Chloride	28-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-179
28146411-4	2017	In addition, SH extract and MC fraction not only scavenged reactive oxygen species efficiently but also caused nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 and subsequently significant induction of antioxidant enzymes such as NAD(P)H:quinone oxidoreductase, heme oxygenase 1 (HO-1), and glutathione reductase.	Methylene Chloride	28-30	crystallin, zeta	Mus musculus	258-280
28146411-4	2017	In addition, SH extract and MC fraction not only scavenged reactive oxygen species efficiently but also caused nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 and subsequently significant induction of antioxidant enzymes such as NAD(P)H:quinone oxidoreductase, heme oxygenase 1 (HO-1), and glutathione reductase.	Methylene Chloride	28-30	heme oxygenase 1	Mus musculus	282-298
28146411-4	2017	In addition, SH extract and MC fraction not only scavenged reactive oxygen species efficiently but also caused nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 and subsequently significant induction of antioxidant enzymes such as NAD(P)H:quinone oxidoreductase, heme oxygenase 1 (HO-1), and glutathione reductase.	Methylene Chloride	28-30	heme oxygenase 1	Mus musculus	300-304
28146411-4	2017	In addition, SH extract and MC fraction not only scavenged reactive oxygen species efficiently but also caused nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 and subsequently significant induction of antioxidant enzymes such as NAD(P)H:quinone oxidoreductase, heme oxygenase 1 (HO-1), and glutathione reductase.	Methylene Chloride	28-30	glutathione reductase	Mus musculus	311-332
28146411-7	2017	Taken together, SH extract and its MC fraction exhibited a neuroprotective effect through Nrf2-mediated induction of antioxidant enzymes, such as HO-1, and warrant further in vivo and clinical studies to confirm its effects and potentially develop a neuroprotective salt substitute or dietary supplement.	Methylene Chloride	35-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
28146411-7	2017	Taken together, SH extract and its MC fraction exhibited a neuroprotective effect through Nrf2-mediated induction of antioxidant enzymes, such as HO-1, and warrant further in vivo and clinical studies to confirm its effects and potentially develop a neuroprotective salt substitute or dietary supplement.	Methylene Chloride	35-37	heme oxygenase 1	Mus musculus	146-150
27783868-1	2017	Tetramethylammonium tetraiodopentabromide [NMe4 ][I4 Br5 ] was the first iodobromide to be synthesized and crystallized in an ionic liquid as well as in dichloromethane.	Methylene Chloride	153-168	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	43-47
29138643-2	2017	The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B.	Methylene Chloride	4-19	monoamine oxidase A	Homo sapiens	83-118
27731627-3	2016	Complex 3, at the same time, in CH2Cl2 in the presence of 2-fold excess of PPh3 readily converts to a new anionic species [(Ph3P)3Cu][Co(2,4-isonido-C2B8H10)2] (4) which retains initial isonido geometry.	Methylene Chloride	32-38	protein phosphatase 4 catalytic subunit	Homo sapiens	75-79
27929170-9	2016	Interestingly, upon addition of NEt3/TFA, both 1 and 4 in CH2Cl2 can switch their luminescence between strong emission at 558 nm and weak emission at 546 nm, due to their acid-/base-induced structural interconversion between the protonation state and the deprotonation state of the qbiH ligand.	Methylene Chloride	58-64	tetraspanin 2	Homo sapiens	32-36
27929170-9	2016	Interestingly, upon addition of NEt3/TFA, both 1 and 4 in CH2Cl2 can switch their luminescence between strong emission at 558 nm and weak emission at 546 nm, due to their acid-/base-induced structural interconversion between the protonation state and the deprotonation state of the qbiH ligand.	Methylene Chloride	58-64	coagulation factor III, tissue factor	Homo sapiens	37-40
29844793-4	2017	The study has been done to investigate cytotoxic effects of dichloromethane brittle star extract and doxorubicin on EL4 cancer cells.	Methylene Chloride	60-75	epilepsy 4	Mus musculus	116-119
29844793-14	2017	All experiments related to apoptosis analysis confirmed that dichloromethane brittle star extract and doxorubicin have a cytotoxic effect on EL4 cells inIC50 concentration.	Methylene Chloride	61-76	epilepsy 4	Mus musculus	141-144
27770908-1	2017	Hydroxyapatite (HAp) nanoparticle stabilized Pickering emulsion was fabricated with poly(l-lactic acid) dissolved in dichloromethane (CH2Cl2) solution as oil phase and HAp aqueous dispersion as aqueous phase.	Methylene Chloride	117-132	BAG cochaperone 1	Homo sapiens	16-19
27770908-1	2017	Hydroxyapatite (HAp) nanoparticle stabilized Pickering emulsion was fabricated with poly(l-lactic acid) dissolved in dichloromethane (CH2Cl2) solution as oil phase and HAp aqueous dispersion as aqueous phase.	Methylene Chloride	134-140	BAG cochaperone 1	Homo sapiens	16-19
28226311-6	2017	The effects of the most potent DCM subfraction in relaxing phenylephrine-precontracted corpora cavernosa, DCM-I, on angiotensin I- or angiotensin II-induced contractions in corpora cavernosa were investigated.	Methylene Chloride	31-34	angiotensinogen	Rattus norvegicus	134-148
27933872-2	2016	As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N"-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2.	Methylene Chloride	277-283	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	54-58
27714273-1	2016	By using polar DMF to relax the H-bonded rigid backbone and to lower the energetic penalty associated with the sterically-crowded environment, the yields for BOP-mediated one-pot synthesis of pentameric macrocycles can be improved from 10-25% as obtained in CH2Cl2 to 13-47% when 15% DMF in CH2Cl2 was used as the reaction medium.	Methylene Chloride	258-264	BOP	Homo sapiens	158-161
27775145-3	2016	Blue emission of EPT in a polar aprotic solvent, i.e., dichloromethane (DCM), completely switches to green upon loading inside MCM-41 due to the conversion from a neutral to a protonated form of the drug inside nano-pores.	Methylene Chloride	55-70	methylmalonyl-CoA mutase	Homo sapiens	127-130
27775145-3	2016	Blue emission of EPT in a polar aprotic solvent, i.e., dichloromethane (DCM), completely switches to green upon loading inside MCM-41 due to the conversion from a neutral to a protonated form of the drug inside nano-pores.	Methylene Chloride	72-75	methylmalonyl-CoA mutase	Homo sapiens	127-130
27714273-1	2016	By using polar DMF to relax the H-bonded rigid backbone and to lower the energetic penalty associated with the sterically-crowded environment, the yields for BOP-mediated one-pot synthesis of pentameric macrocycles can be improved from 10-25% as obtained in CH2Cl2 to 13-47% when 15% DMF in CH2Cl2 was used as the reaction medium.	Methylene Chloride	291-297	BOP	Homo sapiens	158-161
27523328-7	2016	Intending to interpret the experimental data, singlet and triplet states at Cl 2p edge of the CH2Cl2 molecule, corresponding to the Cl (2p   10a1*) and Cl (2p   4b1*) transitions, were calculated at multiconfigurational self-consistent field (MCSCF) level and multireference configuration interaction (MRCI).	Methylene Chloride	94-100	endogenous retrovirus group W member 5	Homo sapiens	76-81
27628907-7	2016	As a consequence, a reductive cyclization of the starting materials is favored in CD2 Cl2 solutions as shown for two beta-(3-iodopropoxy)-substituted tetronates, which underwent in dichloromethane almost exclusive reduction, but gave predominantly the cyclization products in CD2 Cl2 .	Methylene Chloride	181-196	CD2 molecule	Homo sapiens	82-85
27593411-4	2016	An attempt to prepare [Au(L)2 ]+ units, even with less weakly basic solvents like CH2 Cl2 , led to decomposition of the [Al(ORF )4 ]- anion and formation of [NO(CH2 Cl2 )2 ]+ [F(Al(ORF )3 )2 ]- .	Methylene Chloride	82-89	cortactin binding protein 2	Homo sapiens	124-130
27593411-4	2016	An attempt to prepare [Au(L)2 ]+ units, even with less weakly basic solvents like CH2 Cl2 , led to decomposition of the [Al(ORF )4 ]- anion and formation of [NO(CH2 Cl2 )2 ]+ [F(Al(ORF )3 )2 ]- .	Methylene Chloride	82-89	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	181-187
27267866-1	2016	Cesium bis(perfluoro-triphenylborane)amide, Cs[H2NB2(C6F5)6] (1), has been prepared by the reaction of sodium salt and CsF in dichloromethane and water.	Methylene Chloride	126-141	colony stimulating factor 2	Homo sapiens	119-122
27406958-5	2016	Photolysis of 4 in CH2Cl2 at room temperature in the presence of excess PPh3 yields OPPh3 in 173% yield; control experiments implicate 6, NO2( ), and free NO3(-) as the active oxidants.	Methylene Chloride	19-25	caveolin 1	Homo sapiens	72-76
26982213-6	2016	The molar absorption coefficients (epsilon), fluorescence emission intensities, and quantum yield (PhiF) values of the SCCs with different counteranions in CH2Cl2 follow the order PF6(-) > OTf(-) > NO3(-).	Methylene Chloride	156-162	sperm associated antigen 17	Homo sapiens	180-183
27131434-14	2016	The cell cycle arrest in DCM-DS-treated MDA-MB-231 cells is possibly via p53-independent but p21-dependent pathway.	Methylene Chloride	25-28	tumor protein p53	Homo sapiens	73-76
27131434-14	2016	The cell cycle arrest in DCM-DS-treated MDA-MB-231 cells is possibly via p53-independent but p21-dependent pathway.	Methylene Chloride	25-28	H3 histone pseudogene 16	Homo sapiens	93-96
27111528-1	2016	Controlled bromination of a diarylditelluride, R2Te2 (R = 2,6-dimethylphenyl) (6) in dichloromethane led to the formation of a Te(II)-Te(IV) mixed-valent tellurenyl bromide, RBr2TeTeR (7).	Methylene Chloride	85-100	RB transcriptional corepressor like 2	Homo sapiens	174-178
27504189-3	2016	As the authors encountered a laboratory worker with IgAN that progressed to ESRD, we present a case report of IgAN progression due to dichloromethane exposure along with a review of literature.	Methylene Chloride	134-149	IGAN1	Homo sapiens	52-56
27504189-3	2016	As the authors encountered a laboratory worker with IgAN that progressed to ESRD, we present a case report of IgAN progression due to dichloromethane exposure along with a review of literature.	Methylene Chloride	134-149	IGAN1	Homo sapiens	110-114
27504189-5	2016	Although clinical follow-up was initiated under the impression of IgAN based on clinical findings, the patient continued to work for four more years in the same laboratory, during which he was in charge of laboratory analysis with direct exposure to a high concentration of dichloromethane without proper protective equipment.	Methylene Chloride	274-289	IGAN1	Homo sapiens	66-70
26948995-9	2016	The formation of (3)(MsN) was shown and the formation time constant in CH2Cl2 was found to be tau(ISC) = 34 +- 3 ps.	Methylene Chloride	71-77	moesin	Homo sapiens	21-24
26593590-1	2016	The aim of this study was to evaluate the role of glucose transporter-4 (GLUT4) in the anti-diabetic effects of methanol, hexane and dichloromethane extracts of the aerial parts of Ocimum basilicum (OB) and to analyze their phytochemical composition.	Methylene Chloride	133-148	solute carrier family 2 member 4	Rattus norvegicus	73-78
28329744-7	2016	The crude extract (NB1) presented the best antiviral effect, whereas the dichloromethane fraction (NB3) presented an immunomodulatory effect in the inflammatory and anti-inflammatory cytokines.	Methylene Chloride	73-88	contactin 6	Homo sapiens	99-102
26751269-3	2016	Cyclic voltammetry in dichloromethane indicates that, while some of {2}(3+) breaks apart into an [Ru2(ap)4F](+) ([3](+)) monomer in solution, the remaining dimer has a single reversible two-electron redox feature for the Ru2(6/5+) couple that is at a lower potential than that of [3](+).	Methylene Chloride	22-37	doublecortin domain containing 2	Homo sapiens	98-101
26893742-10	2016	The IC50 values obtained for the PC3 cell line were 37.97+-3.87, 51.57+-3.87 and 70.33+-2.36 for the CH2Cl2 fraction, the EtOAc fraction and the methanol extract, respectively.	Methylene Chloride	101-107	chromobox 8	Homo sapiens	33-36
26493883-1	2015	We report that 2,6-lutidine trichloroborane (Lut BCl3 ) reacts with H2 in toluene, bromobenzene, dichloromethane, and Lut solvents producing the neutral hydride, Lut BHCl2 .	Methylene Chloride	97-112	BCL3 transcription coactivator	Homo sapiens	49-53
26615667-4	2015	Structural analysis of crystals grown from CH2Cl2 reveals a complex with the formulation of [Fe(IV)(Osyn)(TMC)(OTf)](OTf) and the shortest Fe(IV) O bond [1.625(4) A] found to date.	Methylene Chloride	43-49	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	106-109
26508036-5	2015	Carbon atom displacements almost completely account for the differences in the symmetric and asymmetric CCl2 stretching intensities of dichloromethane, 103.9 of the total calculated value of 105.2 km mol(-1).	Methylene Chloride	135-150	C-C motif chemokine ligand 2	Homo sapiens	104-108
26458560-3	2015	PCL in dichloromethane increases its viscosity with concentration and molecular weight.	Methylene Chloride	7-22	PHD finger protein 1	Homo sapiens	0-3
26155017-1	2015	The silver(I) species [Ag(benzim(CH2py)2)2]PF6 (1) was prepared by refluxing the ligand precursor [H(benzim(CH2py)2)2]PF6 with Ag2O and aqueous sodium hydroxide in dichloromethane.	Methylene Chloride	164-179	sperm associated antigen 17	Homo sapiens	43-46
26191543-4	2015	Using CH2Cl2 doped wet air as the dopant gas, the detection sensitivities were improved about 4-fold (RDX), 4-fold (PETN), and 3-fold (tetryl) compared with those obtained using the conventional LTP.	Methylene Chloride	6-12	radixin	Homo sapiens	102-105
26220163-1	2015	The photoexcitation and multiphotoionization of the dichloromethane molecule have been studied for photons with energies from 100 eV to the Cl 2p edge, using the time-of-flight multicoincidence technique and synchrotron radiation.	Methylene Chloride	52-67	endogenous retrovirus group W member 5	Homo sapiens	140-145
26396672-5	2015	Then, the scaffold (BMP-2/PELA/BMP-7) was fused by these microcapsules with dichloromethane vapor method.	Methylene Chloride	76-91	bone morphogenetic protein 2	Rattus norvegicus	20-25
26396672-5	2015	Then, the scaffold (BMP-2/PELA/BMP-7) was fused by these microcapsules with dichloromethane vapor method.	Methylene Chloride	76-91	bone morphogenetic protein 7	Rattus norvegicus	31-36
25847124-2	2015	Using phospholipid as a surfactant, BMP-2 was modified as a complex (PBC) for dispersing in PLGA/dichloromethane solution.	Methylene Chloride	97-112	bone morphogenetic protein 2	Homo sapiens	36-41
25325283-7	2015	Although there are gaps in the database for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in vivo), the positive DNA damage assays correlated with tissue and/or species availability of functional glutathione S-transferase (GST) metabolic activity, the key activation pathway for dichloromethane-induced cancer.	Methylene Chloride	327-342	glutathione S-transferase kappa 1	Homo sapiens	244-269
26124811-8	2015	CONCLUSION: Study conducted on Eriobotrya japonica shows that CH2Cl2/MeOH 0:1 fraction inhibits efficiently the hG-IIA phospholipase.	Methylene Chloride	62-68	glucosidase II alpha subunit	Homo sapiens	112-118
26030520-3	2015	Optimized conditions for generating tertiary radicals from N-(acyloxy)phthalimide derivatives of tertiary carboxylic acids by visible-light irradiation in the presence of 1 mol % of commercially available Ru(bpy)3(PF6)2, diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (8), and i-Pr2NEt and their coupling in dichloromethane at room temperature with alkene acceptors were developed.	Methylene Chloride	320-335	sperm associated antigen 17	Homo sapiens	214-217
25558770-4	2015	In contrast, the Rh2(esp)2-catalyzed reaction of 34 in CH2Cl2 afforded a 3-oxocyclohepta[c]pyrrole formed by cyclopropanation of the rhodium carbenoid across the aromatic pi-bond.	Methylene Chloride	55-61	Rh associated glycoprotein	Homo sapiens	17-20
25182870-1	2014	Picosecond time-resolved infrared spectroscopy was used to elucidate early photochemical processes in the diazido complexes M(Cp*)(N3)2(PPh3), M = Rh (), Ir (), using 266 nm and 400 nm excitation in THF, CH2Cl2, MeCN and toluene solutions.	Methylene Chloride	204-210	caveolin 1	Homo sapiens	136-140
25469496-3	2015	In most cases, these complexes are mixtures of fac and mer isomers in a statistical distribution, in both CH2 Cl2 and MeCN.	Methylene Chloride	106-113	FA complementation group C	Homo sapiens	47-50
25636870-3	2015	Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 microg/ml for human aldose reductase in vitro.	Methylene Chloride	0-15	aldo-keto reductase family 1 member B	Homo sapiens	122-138
25636870-4	2015	From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors.	Methylene Chloride	9-24	aldo-keto reductase family 1 member B	Homo sapiens	86-102
25259851-1	2014	We herein present the iodo Meyer-Schuster rearrangement of 3-alkoxypropargyl alcohols for alpha-iodo-alpha,beta-unsaturated esters using iodine or NIS in dichloromethane at ambient temperature.	Methylene Chloride	154-169	solute carrier family 5 member 5	Homo sapiens	147-150
25412041-4	2014	The dichloromethane extract of propolis showed potent inhibition of human MAO-A and MAO-B.	Methylene Chloride	4-19	monoamine oxidase A	Homo sapiens	74-79
25412041-4	2014	The dichloromethane extract of propolis showed potent inhibition of human MAO-A and MAO-B.	Methylene Chloride	4-19	monoamine oxidase B	Homo sapiens	84-89
25354489-1	2014	The application of 2-arylcyclopropylmethanols as substitutes to homoallyl aryl alcohols and their reactions with aliphatic aldehydes in the presence of SnCl4 in CH2Cl2 leads to an efficient Prins cyclization to generate cis-2,6-disubstituted tetrahydropyrans in high yields.	Methylene Chloride	161-167	suppressor of cytokine signaling 2	Homo sapiens	220-225
25387662-2	2014	The Et groups can be easily replaced with F atoms using BF3 Et2O in moist CH2Cl2 to regenerate the BF2-BODIPYs (demasking).	Methylene Chloride	74-80	forkhead box G1	Homo sapiens	99-102
25271783-2	2014	A single-crystal X-ray structure derived from growing crystals from a MeCN-CH2Cl2 solution-phase redox reaction gives a stoichiometry of TTF4[SVW11O40] 2H2O 2CH2Cl2 and reveals that there are two crystallographically different TTF cation moieties based on (TTF2)(2+) dimers.	Methylene Chloride	75-81	transcription termination factor 2	Homo sapiens	257-261
25924408-2	2014	The dechlorination of CCl4 to dichloromethane (CH2Cl2) and chloroform (CHCl3) with a molar ratio of 3:2 was catalyzed by carbon-supported silver (Ag/C) catalyst in methanol solution.	Methylene Chloride	30-45	C-C motif chemokine ligand 4	Homo sapiens	22-26
25924408-2	2014	The dechlorination of CCl4 to dichloromethane (CH2Cl2) and chloroform (CHCl3) with a molar ratio of 3:2 was catalyzed by carbon-supported silver (Ag/C) catalyst in methanol solution.	Methylene Chloride	47-53	C-C motif chemokine ligand 4	Homo sapiens	22-26
24954954-3	2014	A series of BF2bdks with naphthyl and phenyl groups was synthesized, and photophysical properties were investigated in both methylene chloride and poly(lactic acid) (PLA).	Methylene Chloride	124-142	forkhead box G1	Homo sapiens	12-15
25004282-6	2014	The Ru2(5+/4+) and Ru2(5+/6+) processes of Ru2(dpb)4Cl were monitored by UV-vis spectroscopy in both CH2Cl2 and PhCN.	Methylene Chloride	101-107	doublecortin domain containing 2	Homo sapiens	4-7
25004282-6	2014	The Ru2(5+/4+) and Ru2(5+/6+) processes of Ru2(dpb)4Cl were monitored by UV-vis spectroscopy in both CH2Cl2 and PhCN.	Methylene Chloride	101-107	doublecortin domain containing 2	Homo sapiens	19-22
25004282-6	2014	The Ru2(5+/4+) and Ru2(5+/6+) processes of Ru2(dpb)4Cl were monitored by UV-vis spectroscopy in both CH2Cl2 and PhCN.	Methylene Chloride	101-107	doublecortin domain containing 2	Homo sapiens	19-22
25004282-7	2014	A conversion of Ru2(dpb)4Cl to [Ru2(dpb)4(CO)](+) was also carried out by simply bubbling CO gas through a CH2Cl2 solution of Ru2(dpb)4Cl at room temperature.	Methylene Chloride	107-113	doublecortin domain containing 2	Homo sapiens	16-19
25004282-7	2014	A conversion of Ru2(dpb)4Cl to [Ru2(dpb)4(CO)](+) was also carried out by simply bubbling CO gas through a CH2Cl2 solution of Ru2(dpb)4Cl at room temperature.	Methylene Chloride	107-113	doublecortin domain containing 2	Homo sapiens	32-35
25004282-7	2014	A conversion of Ru2(dpb)4Cl to [Ru2(dpb)4(CO)](+) was also carried out by simply bubbling CO gas through a CH2Cl2 solution of Ru2(dpb)4Cl at room temperature.	Methylene Chloride	107-113	doublecortin domain containing 2	Homo sapiens	32-35
25004282-8	2014	The chemically generated [Ru2(dpb)4(CO)](+) complex undergoes several electron transfer processes in CH2Cl2 containing 0.1 M TBAClO4 under a CO atmosphere, and the same reactions were seen for a chemically synthesized sample of Ru2(dpf)4(CO) in CH2Cl2, 0.1 M TBAClO4 under a N2 atmosphere, where dpf = N,N"-diphenylformamidinate anion.	Methylene Chloride	101-107	doublecortin domain containing 2	Homo sapiens	26-29
25004282-8	2014	The chemically generated [Ru2(dpb)4(CO)](+) complex undergoes several electron transfer processes in CH2Cl2 containing 0.1 M TBAClO4 under a CO atmosphere, and the same reactions were seen for a chemically synthesized sample of Ru2(dpf)4(CO) in CH2Cl2, 0.1 M TBAClO4 under a N2 atmosphere, where dpf = N,N"-diphenylformamidinate anion.	Methylene Chloride	245-251	doublecortin domain containing 2	Homo sapiens	26-29
24827859-4	2014	In electrochemical measurements, the cyclocondensed compound exhibited four defined reversible waves with a total spread of 756 mV in CH2Cl2 containing n-Bu4NBArF4 (ArF = 3,5-bis(trifluoromethyl)phenyl), displaying both intra- and inter-biferrocenyl interactions.	Methylene Chloride	134-140	ADP ribosylation factor 3	Homo sapiens	165-172
24909451-3	2014	These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.	Methylene Chloride	44-47	SEC14-like lipid binding 2	Rattus norvegicus	79-82
24909451-3	2014	These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.	Methylene Chloride	44-47	SEC14-like lipid binding 2	Rattus norvegicus	104-107
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	Methylene Chloride	125-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
24507930-4	2014	Each compound can undergo two metal-centered one-electron reductions leading to formation of Co(II) and Co(I) derivatives in CH2Cl2 or pyridine containing 0.1 M tetra-n-butylammonium perchlorate (TBAP).	Methylene Chloride	125-131	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	104-109
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	Methylene Chloride	61-67	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	135-142
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	Methylene Chloride	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25007397-5	2014	Our results reveal that PE2 in dichloromethane solution presents two 2PA allowed bands located at 570 and 710 nm, with cross section of about 320 and 45 GM, respectively.	Methylene Chloride	31-46	ETS2 repressor factor	Homo sapiens	24-27
24760124-2	2014	A reaction of the 44 electron cluster [Pt3(mu-PPh2)3Ph(PPh3)2] (1) with wet AgBF4 afforded the cationic cluster [Pt3(mu2-OH)(mu-PPh2)2(PPh3)3]BF4 (3(BF4)) which slowly transformed into [Pt3(mu2-Cl)(mu-PPh2)2(PPh3)3]BF4 (4(BF4)) upon recrystallization from CH2Cl2.	Methylene Chloride	256-262	protein phosphatase 4 catalytic subunit	Homo sapiens	55-59
24760124-2	2014	A reaction of the 44 electron cluster [Pt3(mu-PPh2)3Ph(PPh3)2] (1) with wet AgBF4 afforded the cationic cluster [Pt3(mu2-OH)(mu-PPh2)2(PPh3)3]BF4 (3(BF4)) which slowly transformed into [Pt3(mu2-Cl)(mu-PPh2)2(PPh3)3]BF4 (4(BF4)) upon recrystallization from CH2Cl2.	Methylene Chloride	256-262	protein phosphatase 4 catalytic subunit	Homo sapiens	135-139
24760124-2	2014	A reaction of the 44 electron cluster [Pt3(mu-PPh2)3Ph(PPh3)2] (1) with wet AgBF4 afforded the cationic cluster [Pt3(mu2-OH)(mu-PPh2)2(PPh3)3]BF4 (3(BF4)) which slowly transformed into [Pt3(mu2-Cl)(mu-PPh2)2(PPh3)3]BF4 (4(BF4)) upon recrystallization from CH2Cl2.	Methylene Chloride	256-262	protein phosphatase 4 catalytic subunit	Homo sapiens	135-139
24947113-13	2014	Although Annexin-V/PI-flow cytometry analysis has confirmed that DCM-DS induced apoptosis in MCF-7 cells, the distinct characteristics of apoptosis such as membrane blebbing, chromatin condensation, nuclear fragmentation and formation of apoptotic bodies were not observed under microscope.	Methylene Chloride	65-68	annexin A5	Homo sapiens	9-18
24607130-3	2014	Among CH2Cl2, CHCl3 and CCl4, CCl4 was chosen as the modifier due to the best peak-to-peak resolution and stability towards the fluctuation of modifier concentration.	Methylene Chloride	6-12	C-C motif chemokine ligand 4	Homo sapiens	30-34
25121057-11	2014	CONCLUSION: The application of dichloromethane on the ridge lap surface of the resin teeth before packing of the dough into the mold significantly increased the bond strength between cross linked acrylic resin teeth and heat cure denture base resin.	Methylene Chloride	31-46	LAP	Homo sapiens	60-63
24689807-6	2014	The propensity for methanol"s self-association in the solvents studied increases in the order: CH2Cl2 ~ CHCl3 < C6H6 < CCl4.	Methylene Chloride	95-101	C-C motif chemokine ligand 4	Homo sapiens	125-129
24644017-2	2014	Chemical oxidation of [Cp(CO)2 Mn C(OEt)Fc] (3 a) and isolation of the oxidised species [3 a][PF6 ] possessing a Mn(II) centre proved possible below -30  C in dichloromethane solution.	Methylene Chloride	159-174	sperm associated antigen 17	Homo sapiens	94-97
24413529-2	2014	The [AlX3(Me2E)] (X = Br or I, E = S; X = Br, E = Te) were made from toluene solution since attempted syntheses in CH2Cl2 resulted in substantial chloride incorporation.	Methylene Chloride	115-121	ALX homeobox 3	Homo sapiens	5-9
24469677-4	2014	Strong fluorescence that is tunable from 500 to 800 nm via variation of the polarity of the solvent and a moderate to good fluorescence quantum yield ranging from 0.24 to 0.58 in dichloromethane were observed in curcumin-BF2 complexes 1.	Methylene Chloride	179-194	forkhead box G1	Homo sapiens	221-224
24413529-7	2014	In CH2Cl2 solution [AlCl3(Me2S)] with added Me2S forms [AlCl3(Me2S)2], and the [AlX2{MeS(CH2)2SMe}2][AlX4] exist as mixtures of cis and trans isomers which undergo rapid exchange at ambient temperatures.	Methylene Chloride	3-9	ALX homeobox 4	Homo sapiens	101-105
24343365-3	2014	The reaction of synthesized dinuclear complexes with imidazole (Im) and N-methylimidazole (N-MeIm) in dry dichloromethane under argon atmosphere afforded the mononuclear complexes of general formula fac-[Re(CO)3(hq)(Im)] and fac-[Re(CO)3(hq)(N-MeIm)] respectively in high yield.	Methylene Chloride	106-121	FA complementation group C	Homo sapiens	199-202
24444890-4	2014	We found that dichloromethane and n-butanol sub-fractions of COCH-Et promoted glucose uptake in differentiated C2C12 cells at 50 mug/mL.	Methylene Chloride	14-29	cochlin	Mus musculus	61-65
24444890-6	2014	These were isolated from the dichloromethane layer of COCH-Et.	Methylene Chloride	29-44	cochlin	Mus musculus	54-58
24343365-3	2014	The reaction of synthesized dinuclear complexes with imidazole (Im) and N-methylimidazole (N-MeIm) in dry dichloromethane under argon atmosphere afforded the mononuclear complexes of general formula fac-[Re(CO)3(hq)(Im)] and fac-[Re(CO)3(hq)(N-MeIm)] respectively in high yield.	Methylene Chloride	106-121	FA complementation group C	Homo sapiens	225-228
24346321-4	2014	In CH2Cl2 solutions, L and the complexes [CuL(PPh3)X] (X = Cl, Br, I) display a luminescence band with lambda(max) = 377 nm and a lifetime of 1.9 ns (ligand-based luminescence (LL*)).	Methylene Chloride	3-9	caveolin 1	Homo sapiens	46-50
24219867-0	2014	Anti-oxidizing effect of the dichloromethane and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling pathway.	Methylene Chloride	29-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
24219867-0	2014	Anti-oxidizing effect of the dichloromethane and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling pathway.	Methylene Chloride	29-44	mitogen-activated protein kinase 1	Mus musculus	180-184
24303085-3	2013	The CH2Cl2 fraction of CIE strongly reduced LMP1-induced NF-kappaB activation and LCL viability with relatively low cytotoxic effects on primary human foreskin fibroblast (HFF), HeLa or Burkitt"s lymphoma (BL41) cells.	Methylene Chloride	4-10	PDZ and LIM domain 7	Homo sapiens	44-48
24822452-3	2014	The results showed that among the selected solvents, n-C6-9, tetrahydrofuran, diethyl ether, cyclohexane and benzene are the poor solvents for [HMIM] OTF, while dichloromethane, acetone, chloroform, ethyl acetate, carbon tetrachloride, methyl acetate, toluene and methanol are the favorite solvents for [HMIM] OTF.	Methylene Chloride	161-176	complement C6	Homo sapiens	55-59
24949447-2	2014	Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.	Methylene Chloride	12-27	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	79-85
24949447-2	2014	Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.	Methylene Chloride	12-27	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195
24949447-3	2014	Additionally, GSTT1 also participates in dichloromethane activation.	Methylene Chloride	41-56	glutathione S-transferase theta 1	Rattus norvegicus	14-19
24550665-6	2014	Real-time polymerase chain reaction assay demonstrated that dichloromethane and dichloroethane reduced the transcript abundance of psaB, whereas that of psbC changed depending on the toxicant after 24 h of exposure.	Methylene Chloride	60-75	photosystem I P700 chlorophyll a apoprotein A2	Chlorella vulgaris	131-135
24352138-3	2014	The width of the micro/nanowires is controlled via tuning the concentration of DB-TTF solution in dichloromethane.	Methylene Chloride	98-113	ras homolog family member H	Homo sapiens	82-85
24374437-3	2014	In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 mug/mL, respectively.	Methylene Chloride	54-69	prostaglandin-endoperoxide synthase 2	Homo sapiens	15-31
24266650-1	2013	A Co(II) anilinosalen catalyst containing proton relays in the first coordination sphere has been synthesized that catalyzes the electrochemical production of hydrogen from acid in dichloromethane and acetonitrile solutions.	Methylene Chloride	181-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
25102692-7	2014	Four constituents, beta-sitosterol, stigmasterol, sesamin, and hyperin were isolated from the methylene chloride fraction, among them, hyperin showed anti-acetylcholinesterase and anti-oxidant activities remarkably.	Methylene Chloride	94-112	acetylcholinesterase	Mus musculus	150-175
24036185-2	2014	Upon 350 nm UV irradiation of Por-SPn (n=1, 2, 4) in dichloromethane, unusual red-shifted absorption spectra were observed with the colour change from pink into green.	Methylene Chloride	53-68	cytochrome p450 oxidoreductase	Homo sapiens	30-33
24036185-7	2014	The reversible photochromic reactions of Por-SPn (n=1, 2, 4) in dichloromethane and THF were investigated by observing absorption and fluorescence spectral changes during UV irradiation or standing in the dark.	Methylene Chloride	64-79	cytochrome p450 oxidoreductase	Homo sapiens	41-44
23173971-2	2014	ether, ethyl acetate, n-hexane, dichloromethane and aqueous extracts of various species of medicinal plants have shown significant in-vivo and in-vitro pharmacological activities against ecto, endo and haemoparasites.	Methylene Chloride	32-47	tripartite motif containing 33	Homo sapiens	187-191
24303085-4	2013	Furthermore, lupeol, a pentacyclic triterpene, was identified in the CH2Cl2 fraction of CIE to attenuate LMP1-induced NF-kappaB activation and LCL viability.	Methylene Chloride	69-75	PDZ and LIM domain 7	Homo sapiens	105-109
24303085-5	2013	This study demonstrates that lupeol is one of active compounds in the CH2Cl2 fraction of CIE that inhibits LMP1-induced NF-kappaB activation and reduces NF-kappaB-dependent LCL viability.	Methylene Chloride	70-76	PDZ and LIM domain 7	Homo sapiens	107-111
24454170-2	2013	The eta(6)-coordination mode of the arene incorporated into the structure was generated in situ after addition of methyl tri-fluoro-methane-sulfonate to the neutral eta(5)-arene tethered precursor complex [RuCl(PPh3)(eta(5):kappa(1)-OC6H4C(NiPr2)=N-PPh2)] in di-chloro-methane solution.	Methylene Chloride	259-276	endothelin receptor type A	Homo sapiens	4-7
24454170-2	2013	The eta(6)-coordination mode of the arene incorporated into the structure was generated in situ after addition of methyl tri-fluoro-methane-sulfonate to the neutral eta(5)-arene tethered precursor complex [RuCl(PPh3)(eta(5):kappa(1)-OC6H4C(NiPr2)=N-PPh2)] in di-chloro-methane solution.	Methylene Chloride	259-276	endothelin receptor type A	Homo sapiens	165-168
24454170-2	2013	The eta(6)-coordination mode of the arene incorporated into the structure was generated in situ after addition of methyl tri-fluoro-methane-sulfonate to the neutral eta(5)-arene tethered precursor complex [RuCl(PPh3)(eta(5):kappa(1)-OC6H4C(NiPr2)=N-PPh2)] in di-chloro-methane solution.	Methylene Chloride	259-276	endothelin receptor type A	Homo sapiens	165-168
23770222-7	2013	UV-initiated radical polymerization of ECT2-AC in dichloromethane resulted in a crosslinked network (xECT2-AC).	Methylene Chloride	50-65	epithelial cell transforming 2	Homo sapiens	39-43
24427928-6	2013	The dichloromethane extract of privet leaves showed a considerable inhibitory effect against COX-1 and COX-2 enzyme activity.	Methylene Chloride	4-19	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	93-98
24427928-6	2013	The dichloromethane extract of privet leaves showed a considerable inhibitory effect against COX-1 and COX-2 enzyme activity.	Methylene Chloride	4-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
23838704-5	2013	The cis-[Ni(1a)2Cl2] (cis-3) is 1.77-1.55 kcal mol(-1) lower in energy than its trans-isomer in polar solvents including CH2Cl2 and THF, while the trans-[Ni(1a)2Br2] (trans-2a) is more stable than the cis-isomer similarly in the gas phase.	Methylene Chloride	121-127	suppressor of cytokine signaling 3	Homo sapiens	22-27
23561211-5	2013	However, dichloromethane extract proved the utmost antioxidant activity in cell (WS1) based-assay (IC50=57 mug/ml) and interesting anticancer capacity against human lung carcinoma (A-549) and colon adenocarcinoma (DLD-1) cells (IC50=37 and 48 mug/ml, respectively).	Methylene Chloride	9-24	paired box 3	Homo sapiens	81-84
23683960-7	2013	The preparation of MEH-PPV nanoparticles from DCM solution provides average size of about 127 nm.	Methylene Chloride	46-49	epoxide hydrolase 1	Homo sapiens	19-22
23683960-14	2013	The use of DCM and THF as initial solvents provides the MEH-PPV nanoparticles with green (lambda max=535 nm) and red (lambda max=590 nm) photoemission, respectively.	Methylene Chloride	11-14	epoxide hydrolase 1	Homo sapiens	56-59
23808375-1	2013	Activation barriers to the electrochemical oxidation for the series PPh3-n(dipp)n (dipp = 2,6-diisopropylphenyl) in CH2Cl2/Bu4NPF6 were measured using large amplitude FT ac voltammetry.	Methylene Chloride	116-122	protein phosphatase 4 catalytic subunit	Homo sapiens	68-72
23922034-6	2013	It has been concluded that while DFT 6-31+G(d,p) method provides accurate enol ratio in DMSO, MeOH, and DCM, in order to obtain accurate results for the other solvents the MP2 aug-cc-pVDZ level calculations should be used for CH3CN and CHCl3 solutions.	Methylene Chloride	104-107	tryptase pseudogene 1	Homo sapiens	172-175
23763627-1	2013	The X-ray crystal structure of a previously reported extremely strong quadruple NH   N AAAA-DDDD hydrogen-bond array [5 4] (K(a) = 1.5 x 10(6) M(-1) in CH3CN; K(a) > 3 x 10(12) M(-1) in CH2Cl2) features four short linear hydrogen bonds.	Methylene Chloride	189-195	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	92-96
23763627-2	2013	Changing the two benzimidazole groups of the DDDD unit to triazole groups replaces two of the NH   N hydrogen bonds with CH   N interactions (complex [5 6]), but only reduces the association constant in CH3CN by 2 orders of magnitude (K(a) = 2.6 x 10(4) M(-1) in CH3CN; K(a) > 1 x 10(7) M(-1) in CH2Cl2).	Methylene Chloride	299-305	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	45-49
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase, mu 1	Mus musculus	0-5
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase, theta 1	Mus musculus	11-16
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase mu 1	Homo sapiens	83-88
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase theta 1	Homo sapiens	99-104
23506349-8	2013	Gstm1- and Gstt1-null mice have potential as human models, since null genotypes of GSTM1/Gstm1 and GSTT1/Gstt1 decreased hepatic GST activities toward p-nitrobenzyl chloride and dichloromethane, respectively, in both humans and mice.	Methylene Chloride	178-193	glutathione S-transferase theta 1	Homo sapiens	105-110
23659712-4	2013	The azido-chlorido ligand back exchange was studied in detail by NMR techniques in [Bi(N3)6](3-) and Bi(N3)3 when chlorinated solvents such as CH2Cl2 were utilized leading to the formation of CH2(N3)Cl and/or HN3 along with partially chlorinated bismuth azides.	Methylene Chloride	143-149	MT-RNR2 like 3 (pseudogene)	Homo sapiens	209-212
24146513-6	2013	All three extracts significantly inhibited CYP1A1, CYP1A2 and CYP 2E1 activities, but only dichloromethane extract enhanced CYP2B activity.	Methylene Chloride	91-106	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	124-129
24146513-8	2013	As an indicator for metabolic drug interaction, pentobarbital-induced sleeping time was decreased in connection with the induction of CYP2B activity between 7 and 28 days of dichloromethane extract and EPMC-treated animals when compared to control.	Methylene Chloride	174-189	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	134-139
22834918-4	2013	However, organic solvents, such as chloroform or dichloromethane, are usually used for the fabrication of a PLCL scaffold through conventional methods.	Methylene Chloride	49-64	phospholipase C-like 1	Mus musculus	108-112
23475264-3	2013	Diffusion of iodine solution in n-hexane to the trans-[Os(PQ) (PPh3)2(CO)(Br)] solution in CH2Cl2 generates the crystals of trans-[Os(PQ)(PPh3)2(CO)(Br)](+)I3(-), (4(+))I3(-)), in lower yields.	Methylene Chloride	91-97	caveolin 1	Homo sapiens	63-67
23475264-3	2013	Diffusion of iodine solution in n-hexane to the trans-[Os(PQ) (PPh3)2(CO)(Br)] solution in CH2Cl2 generates the crystals of trans-[Os(PQ)(PPh3)2(CO)(Br)](+)I3(-), (4(+))I3(-)), in lower yields.	Methylene Chloride	91-97	caveolin 1	Homo sapiens	138-142
23590521-1	2013	The reaction of SiX4 (X = Cl or Br) with PMe3 in anhydrous CH2Cl2 forms trans-[SiX4(PMe3)2], while the diphosphines, Me2P(CH2)2PMe2, Et2P(CH2)2PEt2, and o-C6H4(PMe2)2 form cis-[SiX4(diphosphine)], all containing six-coordinate silicon centers.	Methylene Chloride	59-65	SIX homeobox 4	Homo sapiens	16-20
23590521-1	2013	The reaction of SiX4 (X = Cl or Br) with PMe3 in anhydrous CH2Cl2 forms trans-[SiX4(PMe3)2], while the diphosphines, Me2P(CH2)2PMe2, Et2P(CH2)2PEt2, and o-C6H4(PMe2)2 form cis-[SiX4(diphosphine)], all containing six-coordinate silicon centers.	Methylene Chloride	59-65	SIX homeobox 4	Homo sapiens	79-83
23590521-1	2013	The reaction of SiX4 (X = Cl or Br) with PMe3 in anhydrous CH2Cl2 forms trans-[SiX4(PMe3)2], while the diphosphines, Me2P(CH2)2PMe2, Et2P(CH2)2PEt2, and o-C6H4(PMe2)2 form cis-[SiX4(diphosphine)], all containing six-coordinate silicon centers.	Methylene Chloride	59-65	SIX homeobox 4	Homo sapiens	79-83
23529836-4	2013	The use of relatively fast-extracting ethyl acetate and slowly extracting dichloromethane as shell- and core-phase solvents, respectively, was found to produce DWMS with well-defined core-shell structure, high BSA encapsulation efficiency, and the desired localization of protein in the particle core.	Methylene Chloride	74-89	albumin	Homo sapiens	210-213
23630612-4	2013	Activity-guided fractionation of the dichloromethane extract led to the isolation of six polyacetylenes, which displayed properties of selective partial PPARgamma agonists in the luciferase reporter model.	Methylene Chloride	37-52	peroxisome proliferator activated receptor gamma	Homo sapiens	153-162
23464793-6	2013	However, excimer emissions were only observed for F5-F7 in dilute cyclohexane and for F6 and F7 in dilute methylene chloride, respectively.	Methylene Chloride	106-124	ATP synthase peripheral stalk subunit F6	Homo sapiens	86-95
23517550-15	2013	The CH2Cl2 solution of Co(salen)(X) shows an intense near-IR absorption, which is assigned as overlapped transitions from a ligand-to-metal charge transfer in Co(III)(salen)(X) and a ligand-to-ligand charge transfer in Co(II)(salen( +))(X).	Methylene Chloride	4-10	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	159-166
23517550-15	2013	The CH2Cl2 solution of Co(salen)(X) shows an intense near-IR absorption, which is assigned as overlapped transitions from a ligand-to-metal charge transfer in Co(III)(salen)(X) and a ligand-to-ligand charge transfer in Co(II)(salen( +))(X).	Methylene Chloride	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-225
23529036-3	2013	The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia reflexa showed potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, with IC50 values in the 8.49 to 52.23 g/mL range.	Methylene Chloride	4-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
23529036-3	2013	The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia reflexa showed potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, with IC50 values in the 8.49 to 52.23 g/mL range.	Methylene Chloride	4-19	butyrylcholinesterase	Homo sapiens	137-158
23529036-3	2013	The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia reflexa showed potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, with IC50 values in the 8.49 to 52.23 g/mL range.	Methylene Chloride	4-19	butyrylcholinesterase	Homo sapiens	160-164
23000891-5	2013	RESULTS: Administration of BV HCl, MC, or DFO showed significant reduction of inflammatory activity in comparison to controls leading to lower myeloperoxidase activity in the pancreas, less edema, lower ascites volumes, and preservation of tissue integrity (P < 0.05).	Methylene Chloride	35-37	myeloperoxidase	Rattus norvegicus	143-158
23590386-2	2013	Among the solvents used, including dichloromethane, chloroform, tetrahydrofuran, and carbon disulfide (CS2), CS2 was the best to induce fibril formation because its solubility parameter is closest to those of the P3AT derivatives.	Methylene Chloride	35-50	chorionic somatomammotropin hormone 2	Homo sapiens	109-112
23516976-1	2013	The photophysical properties of a polymer of intrinsic microporosity, namely, PIM-1, were characterized by steady-state and time-resolved fluorescence for solutions of PIM-1 in dichloromethane (DCM) or for a membrane made of PIM-1 immersed in hexane to which a quencher was added.	Methylene Chloride	177-192	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	78-83
23683258-10	2013	Bile flow increased after DCM supplementation and was associated with a concomitant increase of biliary glutathione and higher hepatic multidrug resistance-associated protein 2 (Mrp2) expression.	Methylene Chloride	26-29	ATP binding cassette subfamily C member 2	Rattus norvegicus	135-176
23683258-10	2013	Bile flow increased after DCM supplementation and was associated with a concomitant increase of biliary glutathione and higher hepatic multidrug resistance-associated protein 2 (Mrp2) expression.	Methylene Chloride	26-29	ATP binding cassette subfamily C member 2	Rattus norvegicus	178-182
22307937-2	2012	We show here that a dichloromethane extract of Ratanhiae radix ( RR_EX) dose-dependently inhibits human recombinant PTP1B in vitro and enhances insulin-stimulated glucose uptake in murine myocytes.	Methylene Chloride	20-35	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	116-121
22728431-3	2012	PSA containing crystalline ketotifen (PSA-Crystalline) and that containing amorphous ketotifen (PSA-Amorphous) were prepared by the solvent casting method using n-hexane and dichloromethane, respectively.	Methylene Chloride	174-189	aminopeptidase puromycin sensitive	Rattus norvegicus	0-3
22670799-2	2012	These extremely reactive complexes abstract chloride from dichloromethane to generate U(NDipp)(2)Cl(R(2)bpy)(2) or U(NDipp)(2)Cl(tppo)(3) (Dipp = 2,6-(i)Pr(2)C(6)H(3)).	Methylene Chloride	58-73	nudix hydrolase 4	Homo sapiens	139-147
24088696-5	2013	Investigations for the possible mechanism underlying the induction of apoptosis showed that CH2Cl2 fraction or compound 7 induced apoptosis through down-regulation of Bcl-2, up-regulation of Bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) in HL-60 cells.	Methylene Chloride	92-98	BCL2 apoptosis regulator	Homo sapiens	167-172
24088696-5	2013	Investigations for the possible mechanism underlying the induction of apoptosis showed that CH2Cl2 fraction or compound 7 induced apoptosis through down-regulation of Bcl-2, up-regulation of Bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) in HL-60 cells.	Methylene Chloride	92-98	BCL2 associated X, apoptosis regulator	Homo sapiens	191-194
24088696-5	2013	Investigations for the possible mechanism underlying the induction of apoptosis showed that CH2Cl2 fraction or compound 7 induced apoptosis through down-regulation of Bcl-2, up-regulation of Bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) in HL-60 cells.	Methylene Chloride	92-98	caspase 9	Homo sapiens	208-217
24088696-5	2013	Investigations for the possible mechanism underlying the induction of apoptosis showed that CH2Cl2 fraction or compound 7 induced apoptosis through down-regulation of Bcl-2, up-regulation of Bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) in HL-60 cells.	Methylene Chloride	92-98	caspase 3	Homo sapiens	231-240
24088696-5	2013	Investigations for the possible mechanism underlying the induction of apoptosis showed that CH2Cl2 fraction or compound 7 induced apoptosis through down-regulation of Bcl-2, up-regulation of Bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) in HL-60 cells.	Methylene Chloride	92-98	poly(ADP-ribose) polymerase 1	Homo sapiens	257-284
24088696-5	2013	Investigations for the possible mechanism underlying the induction of apoptosis showed that CH2Cl2 fraction or compound 7 induced apoptosis through down-regulation of Bcl-2, up-regulation of Bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) in HL-60 cells.	Methylene Chloride	92-98	poly(ADP-ribose) polymerase 1	Homo sapiens	286-290
24088696-6	2013	Furthermore, the apoptosis induction of HL-60 cell by CH2Cl2 fraction or compound 7 was attended by the decreasing of phospho-extracellular signal-regulated kinase (ERK) 1/2 and C-myc.	Methylene Chloride	54-60	mitogen-activated protein kinase 1	Homo sapiens	118-173
24088696-6	2013	Furthermore, the apoptosis induction of HL-60 cell by CH2Cl2 fraction or compound 7 was attended by the decreasing of phospho-extracellular signal-regulated kinase (ERK) 1/2 and C-myc.	Methylene Chloride	54-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	178-183
24088696-7	2013	These results indicated that the CH2Cl2 fraction and compound 7 could induce the apoptosis of HL-60 cells via the inactivation of ERK 1/2 and the decrease of C-myc.	Methylene Chloride	33-39	mitogen-activated protein kinase 3	Homo sapiens	130-137
24088696-7	2013	These results indicated that the CH2Cl2 fraction and compound 7 could induce the apoptosis of HL-60 cells via the inactivation of ERK 1/2 and the decrease of C-myc.	Methylene Chloride	33-39	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
23135783-0	2013	The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata             inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis.	Methylene Chloride	4-19	nucleophosmin 1	Homo sapiens	95-98
23135783-0	2013	The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata             inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis.	Methylene Chloride	4-19	ALK receptor tyrosine kinase	Homo sapiens	99-102
22438130-4	2013	The methylene chloride fraction of C. indicum (MCI) exhibited strong cytotoxic activity as compared with the other fractions and clearly suppressed constitutive STAT3 activation against both DU145 and U266 cells, but not MDA-MB-231 cells.	Methylene Chloride	4-22	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	47-50
22438130-4	2013	The methylene chloride fraction of C. indicum (MCI) exhibited strong cytotoxic activity as compared with the other fractions and clearly suppressed constitutive STAT3 activation against both DU145 and U266 cells, but not MDA-MB-231 cells.	Methylene Chloride	4-22	signal transducer and activator of transcription 3	Homo sapiens	161-166
24146440-5	2013	Herein we assess the effects of dichloromethane fraction from A. leiocarpus stem bark (ALF), selected as the most active on cyclic nucleotide phosphodiesterases (PDEs) and characterized its specificity towards purified vascular PDE1 to PDE5 isoenzymes and study its effects on a vascular model.	Methylene Chloride	32-47	general transcription factor IIA subunit 1 like	Homo sapiens	87-90
24146440-5	2013	Herein we assess the effects of dichloromethane fraction from A. leiocarpus stem bark (ALF), selected as the most active on cyclic nucleotide phosphodiesterases (PDEs) and characterized its specificity towards purified vascular PDE1 to PDE5 isoenzymes and study its effects on a vascular model.	Methylene Chloride	32-47	phosphodiesterase 5A	Homo sapiens	236-240
23014114-2	2012	Upon addition of a tetrahydrofuran (THF) solution of Hg(2+), the dichloromethane (DCM) solution of Ir1 gave a visual color change and significant fluorescent quenching.	Methylene Chloride	65-80	nischarin	Homo sapiens	99-102
23014114-2	2012	Upon addition of a tetrahydrofuran (THF) solution of Hg(2+), the dichloromethane (DCM) solution of Ir1 gave a visual color change and significant fluorescent quenching.	Methylene Chloride	82-85	nischarin	Homo sapiens	99-102
23240420-2	2012	By adding into dichloromethane solution containing Eu-TNS, the fluorescent intensities were enhanced gradually and regularly.	Methylene Chloride	15-30	tensin 1	Homo sapiens	54-57
22813233-2	2012	Together, these two mechanisms quantitatively describe the quenching of photoluminescence upon addition of BQ to PbS QDs in dichloromethane solution.	Methylene Chloride	124-139	cholinergic receptor muscarinic 3	Homo sapiens	113-116
22307937-2	2012	We show here that a dichloromethane extract of Ratanhiae radix ( RR_EX) dose-dependently inhibits human recombinant PTP1B in vitro and enhances insulin-stimulated glucose uptake in murine myocytes.	Methylene Chloride	20-35	insulin	Homo sapiens	144-151
22285522-0	2012	Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: suppression of NF-kappaB activation and MAPK signaling.	Methylene Chloride	29-44	mitogen-activated protein kinase 1	Mus musculus	140-144
22101976-5	2012	RESULTS: Catalase-loaded SLN were prepared by the double emulsification method and solvent evaporation techniques, using acetone-methylene chloride (1:1, v/v) as an organic solvent, SPC-tripalmitin as oil phase and Poloxamer 188 as a surfactant.	Methylene Chloride	129-147	catalase-3	Glycine max	9-17
22029900-7	2011	Crystals of [Zn(2)(L(C4))(4)(DMSO)(2)] 2(CH(2)Cl(2)) undergo a single-crystal to single-crystal gas/solid guest exchange upon exposure to atmospheric moisture, or faster if placed under vacuum or heated under dry gas to 100  C, followed by atmospheric moisture, to yield [Zn(2)(L(C4))(4)(DMSO)(2)] 3.9(H(2)O).	Methylene Chloride	41-51	gastrin	Homo sapiens	96-99
22170331-3	2012	In addition, in liver with GSTT1/Gstt1-null genotype, GST activity toward dichloromethane (DCM) was significantly decreased in both humans and mice.	Methylene Chloride	74-89	glutathione S-transferase theta 1	Homo sapiens	27-32
22170331-3	2012	In addition, in liver with GSTT1/Gstt1-null genotype, GST activity toward dichloromethane (DCM) was significantly decreased in both humans and mice.	Methylene Chloride	74-89	glutathione S-transferase theta 1	Homo sapiens	33-38
22077105-3	2012	Ring fusion using standard Scholl reaction conditions (FeCl(3), dichloromethane) occurs for perylene-substituted porphyrins to give a porphyrin beta,meso annulated with perylene rings (0.7:1 ratio of syn and anti isomers).	Methylene Chloride	64-79	synemin	Homo sapiens	200-203
22029900-7	2011	Crystals of [Zn(2)(L(C4))(4)(DMSO)(2)] 2(CH(2)Cl(2)) undergo a single-crystal to single-crystal gas/solid guest exchange upon exposure to atmospheric moisture, or faster if placed under vacuum or heated under dry gas to 100  C, followed by atmospheric moisture, to yield [Zn(2)(L(C4))(4)(DMSO)(2)] 3.9(H(2)O).	Methylene Chloride	41-51	gastrin	Homo sapiens	213-216
21671562-1	2011	Reductive elimination of C-Cl and C-C bonds from binuclear organopalladium complexes containing Pd-Pd bonds with overall formal oxidation state +III are explored by density functional theory for dichloromethane and acetonitrile solvent environments.	Methylene Chloride	195-210	crystallin gamma C	Homo sapiens	25-29
21830754-4	2011	The newly reported complexes display intense luminescence in dichloromethane solutions with maxima at 538 (Ir1) and 477 nm (Ir2) at 298 K (496 and 468 nm at 77 K, respectively) and emission quantum yields reaching ~18% for Ir1.	Methylene Chloride	61-76	nischarin	Homo sapiens	107-110
21830754-4	2011	The newly reported complexes display intense luminescence in dichloromethane solutions with maxima at 538 (Ir1) and 477 nm (Ir2) at 298 K (496 and 468 nm at 77 K, respectively) and emission quantum yields reaching ~18% for Ir1.	Methylene Chloride	61-76	nischarin	Homo sapiens	223-226
21671562-5	2011	Calculations for the symmetrical dichloro complex I indicate that a similar dissociative pathway for C-Cl coupling is competitive with a direct (nondissociative) pathway in acetonitrile, but the direct pathway is favored in dichloromethane.	Methylene Chloride	224-239	crystallin gamma C	Homo sapiens	101-105
21699753-5	2011	Phosphorylation of the pro-inflammatory transcription factor complex nuclear factor-kappa B (NF-kappaB) p65 and expression of inducible nitric oxide synthase (iNOS), one of its downstream proteins, were also suppressed by DCM fraction.	Methylene Chloride	222-225	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-91
21347498-1	2011	An easy, efficient and concise approach to tetrahydrofluorene [6,5,6]ABC tricyclic core embedded new polycycles has been achieved under relatively mild and catalytic Nazarov type electrocyclization conditions, using 2 mol% of Sc(OTf)(3) in anhydrous DCM (dichloromethane) at room temperature, with high yields.	Methylene Chloride	250-253	POU class 5 homeobox 1	Homo sapiens	226-235
21347498-1	2011	An easy, efficient and concise approach to tetrahydrofluorene [6,5,6]ABC tricyclic core embedded new polycycles has been achieved under relatively mild and catalytic Nazarov type electrocyclization conditions, using 2 mol% of Sc(OTf)(3) in anhydrous DCM (dichloromethane) at room temperature, with high yields.	Methylene Chloride	255-270	POU class 5 homeobox 1	Homo sapiens	226-235
21699753-5	2011	Phosphorylation of the pro-inflammatory transcription factor complex nuclear factor-kappa B (NF-kappaB) p65 and expression of inducible nitric oxide synthase (iNOS), one of its downstream proteins, were also suppressed by DCM fraction.	Methylene Chloride	222-225	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
21699753-5	2011	Phosphorylation of the pro-inflammatory transcription factor complex nuclear factor-kappa B (NF-kappaB) p65 and expression of inducible nitric oxide synthase (iNOS), one of its downstream proteins, were also suppressed by DCM fraction.	Methylene Chloride	222-225	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	104-107
21699753-5	2011	Phosphorylation of the pro-inflammatory transcription factor complex nuclear factor-kappa B (NF-kappaB) p65 and expression of inducible nitric oxide synthase (iNOS), one of its downstream proteins, were also suppressed by DCM fraction.	Methylene Chloride	222-225	nitric oxide synthase 2, inducible	Mus musculus	126-157
21699753-5	2011	Phosphorylation of the pro-inflammatory transcription factor complex nuclear factor-kappa B (NF-kappaB) p65 and expression of inducible nitric oxide synthase (iNOS), one of its downstream proteins, were also suppressed by DCM fraction.	Methylene Chloride	222-225	nitric oxide synthase 2, inducible	Mus musculus	159-163
21674787-3	2011	The hexane and CH(2) Cl(2) extracts showed the strongest cytotoxic activity against the C32 cell line with IC(50) values of 11.2 and 13.6 mug/ml, respectively, and the AcOEt extract was the most active extract against the COR-L23 cell line (IC(50) of 20.9 mug/ml).	Methylene Chloride	15-26	chemokine like factor	Homo sapiens	88-91
21514904-4	2011	The extraction of the DM-PIT-1 from the plasma and tumor tissue with methylene chloride resulted in its high recovery (70-80%).	Methylene Chloride	69-87	POU domain, class 1, transcription factor 1	Mus musculus	25-30
21111586-0	2011	A methylene chloride fraction of Saururus chinensis induces apoptosis through the activation of caspase-3 in prostate and breast cancer cells.	Methylene Chloride	2-20	caspase 3	Homo sapiens	96-105
21845078-1	2011	Catalase-loaded solid lipid nanoparticles (SLNs) were prepared by the double emulsion method (w/o/w) and solvent evaporation techniques, using acetone/methylene chloride (1:1) as an organic solvent, lecithin and triglyceride as oil phase and Poloxmer 188 as a surfactant.	Methylene Chloride	151-169	catalase	Homo sapiens	0-8
21182530-2	2011	The quantum yields Phi(Delta) of singlet molecular oxygen formation of berberine, palmatine and sanguinarine are moderate in dichloromethane (0.2-0.6) and much smaller in acetonitrile or trifluoroethanol.	Methylene Chloride	125-140	glucose-6-phosphate isomerase	Homo sapiens	19-22
24278544-6	2011	In conclusion,the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-alpha and IL-1beta in LPS-stimulated macrophages.	Methylene Chloride	74-89	interleukin 6	Mus musculus	171-175
24278544-6	2011	In conclusion,the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-alpha and IL-1beta in LPS-stimulated macrophages.	Methylene Chloride	74-89	tumor necrosis factor	Mus musculus	177-186
24278544-6	2011	In conclusion,the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-alpha and IL-1beta in LPS-stimulated macrophages.	Methylene Chloride	74-89	interleukin 1 beta	Mus musculus	191-199
20632303-4	2011	Treatment of Mono Mac 6 cells with the residue of a crude dichloromethane extract of rose hip powder significantly and concentration dependently inhibited the lipopolysaccharide induced interleukin-6 release.	Methylene Chloride	58-73	interleukin 6	Homo sapiens	186-199
21403939-7	2011	The application of dichloromethane on the ridge lap areas of teeth resulted in a significant improvement of bond strengths in heat- and auto-cured resins.	Methylene Chloride	19-34	LAP	Homo sapiens	48-51
21040769-3	2011	MATERIALS AND METHODS: RAW 264.7 cells were pretreated with the methylene chloride fraction of TO (MTO) and stimulated with LPS.	Methylene Chloride	64-82	chloride channel, voltage-sensitive 1	Mus musculus	99-102
21040769-13	2011	CONCLUSIONS: We demonstrate here the evidence that the methylene chloride fraction of Thuja orientalis (MTO) potentially inhibits the biomarkers related to inflammation in vitro and in vivo, and might be provided as a potential candidate for the treatment of inflammatory diseases.	Methylene Chloride	55-73	chloride channel, voltage-sensitive 1	Mus musculus	104-107
21916258-8	2011	In contrast, only dichloromethane and methanol extracts enhanced CYP2B activity.	Methylene Chloride	18-33	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	65-70
20923413-2	2011	The present study aims to fabricate composite nanofibrous substrate of Chit/HA (chitosan/HA - 80:25) prepared by dissolving in TFA/DCM (trifluoroacetic acid/dichloromethane) (70:30, w/w) for 5 days and electrospun to fabricate a scaffold for bone tissue engineering.	Methylene Chloride	157-172	chitinase 1	Homo sapiens	71-75
20837120-0	2010	Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype.	Methylene Chloride	45-60	glutathione S-transferase theta 1	Homo sapiens	79-110
21082792-5	2010	A particular situation was found in the reaction with SnMe(3)Cl, this giving a product existing in both tautomeric forms, with the phosphide-like complex [MCp{P(OSnMe(3))R*}(CO)(2)] prevailing at room temperature and the tautomer [MCp{P(O)R*}(CO)(2)(SnMe(3))] being the unique species present below 203 K in dichloromethane solution.	Methylene Chloride	308-323	CD46 molecule	Homo sapiens	155-158
20666506-2	2010	A theoretical electronic structure study of this unusual for alpha-oxoketenes [2 + 2] cyclization reaction both in the gas phase (DFT, MP2) and in dichloromethane solution (DFT), provides support for (a) a single-step, transition-state (involving a four-membered cyclic ring) charge-controlled, concerted mechanism and (b) a [4 + 2] cyclization reaction, not observed but studied theoretically in this study.	Methylene Chloride	147-162	tryptase pseudogene 1	Homo sapiens	135-138
20843538-2	2010	Total PAH ( (28)PAH) concentrations in the dichloromethane-soluble fraction ("binder"), comprising 5-10% of pavement mass, were as high as 200,000 mgkg(-1) (10,000 mgkg(-1) in binder+aggregate).	Methylene Chloride	43-58	phenylalanine hydroxylase	Homo sapiens	6-9
20961147-3	2010	Thus, the reaction of hmpH with Mn(O(2)CPh)(2) in CH(2)Cl(2)/MeOH led to isolation of octanuclear complex 1, whereas the analogous reaction in the presence of NEt(3) gave hexadecanuclear complex 2.	Methylene Chloride	50-60	hematopoietically expressed homeobox	Homo sapiens	22-26
20922239-3	2010	The complexes can be readily obtained by the addition of the thione ligand to a CuX-diphosphane adduct in dichloromethane-ethanol solution.	Methylene Chloride	106-121	cut like homeobox 1	Homo sapiens	80-83
20349936-6	2010	Reaction of a dichloromethane solution of 1 with a 36% aqueous solution of HCHO in the presence of H(2)SO(4) quantitatively converts 1 at room temperature to a 1:1 mixture of the syn- and anti-isomers of B(18)H(22).	Methylene Chloride	14-29	synemin	Homo sapiens	179-182
20483385-7	2010	Intragastric administration with MC significantly decreased morbidity and mortality of CLP-induced ALI as confirmed by blinded histological changes, myeloperoxidase activity, mortality, and the content of TNF-alpha and IL-10.	Methylene Chloride	33-35	myeloperoxidase	Rattus norvegicus	149-164
20483385-7	2010	Intragastric administration with MC significantly decreased morbidity and mortality of CLP-induced ALI as confirmed by blinded histological changes, myeloperoxidase activity, mortality, and the content of TNF-alpha and IL-10.	Methylene Chloride	33-35	tumor necrosis factor	Rattus norvegicus	205-214
20483385-7	2010	Intragastric administration with MC significantly decreased morbidity and mortality of CLP-induced ALI as confirmed by blinded histological changes, myeloperoxidase activity, mortality, and the content of TNF-alpha and IL-10.	Methylene Chloride	33-35	interleukin 10	Rattus norvegicus	219-224
20437033-2	2010	In the present study, it was demonstrated that the dichloromethane extract of Echinops grijisii had phase II detoxifying enzyme-inducing and nuclear factor-kappaB (NF-kappaB)-inhibiting activities, which might be attributed to the modification of key cysteine residues in Keap1 and NF-kappaB by Michael addition acceptors in it.	Methylene Chloride	51-66	kelch like ECH associated protein 1	Homo sapiens	272-277
20364836-6	2010	Reaction of mapm with 1 equiv of [Ru(CO)(4)(eta(2)-C(2)H(4))] in dichloromethane initially produces [Ru(CO)(4)(P-mapm)] which, over a 24 h period with exposure to ambient light, is completely converted to the P,P"-chelate, [Ru(CO)(3)(P,P"-mapm)], by photodissociation of carbon monoxide.	Methylene Chloride	65-80	endothelin receptor type A	Homo sapiens	44-47
20353154-1	2010	The isomerization dynamics of five labile octahedral Co(II) compounds have been investigated by variable temperature and pressure (1)H and (19)F NMR spectroscopy in dichloromethane solution.	Methylene Chloride	165-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-59
19900427-1	2010	The crucial step in the preparation of the title arsonolipids starting from the dichloromethane-soluble dithioarsonite CH(2)(OH)CH(OH)CH(2)-As(SPh)(2) is to avoid an internal cyclization during the acylation which protects the primary -OH group from being acylated.	Methylene Chloride	80-95	surfactant associated 3	Homo sapiens	143-146
19921058-2	2009	of CuX in dichloromethane to afford octanuclear copper(I) complexes, [Cu(8)(mu-X)(8)(mu-dpmppm)(2)] (X = Cl (1a), Br (1b), I (1c)), which involve a ladder-type {Cu(8)(mu-X)(2)(mu(3)-X)(6)} core supported by two dpmppm ligands in anti arrangement.	Methylene Chloride	10-25	cut like homeobox 1	Homo sapiens	3-6
19660780-1	2009	Photolysis of deca-bromodiphenyl ether (BDE-209) was investigated in tetrahydrofuran, dichloromethane, isopropanol, acetone, ethanol, methanol, acetonitrile and dimethylsulfoxide.	Methylene Chloride	86-101	homeobox D13	Homo sapiens	40-43
20193372-8	2009	The median expression of HO-1 in MC group was no significantly different with that in control group (P > 0.05).	Methylene Chloride	33-35	heme oxygenase 1	Rattus norvegicus	25-29
19842708-3	2009	The addition of Poisson-Boltzmann (PBF) continuum approximation (dichloromethane) corrected the disagreement and afforded energies consistent with experimental results.	Methylene Chloride	65-80	PTTG1 interacting protein	Homo sapiens	35-38
19724892-6	2009	In HL-60 cells 50% proliferation inhibition was achieved by 1.7 microg dichloromethane extract/ml medium and correlated with the activation of Chk2, down-regulation of Cdc25A, suppression of cyclin D1 level, and transient induction of p21.	Methylene Chloride	71-86	checkpoint kinase 2	Homo sapiens	143-147
19724892-6	2009	In HL-60 cells 50% proliferation inhibition was achieved by 1.7 microg dichloromethane extract/ml medium and correlated with the activation of Chk2, down-regulation of Cdc25A, suppression of cyclin D1 level, and transient induction of p21.	Methylene Chloride	71-86	cyclin D1	Homo sapiens	191-200
19724892-6	2009	In HL-60 cells 50% proliferation inhibition was achieved by 1.7 microg dichloromethane extract/ml medium and correlated with the activation of Chk2, down-regulation of Cdc25A, suppression of cyclin D1 level, and transient induction of p21.	Methylene Chloride	71-86	H3 histone pseudogene 16	Homo sapiens	235-238
19834287-1	2009	Our previous studies showed that administration of a subtoxic dose of acetaminophen (APAP) to female rats increased generation of carbon monoxide from dichloromethane, a metabolic reaction catalyzed mainly by cytochrome P450 (CYP) 2E1.	Methylene Chloride	151-166	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	209-234
19497357-6	2009	The antinociception caused by the dichloromethane fraction was significantly attenuated by pre-treatment of mice with p-chlorophenylalanine methyl ester (PCPA, an inhibitor of serotonin synthesis, 100 mg/kg once a day for 4 consecutive days) and WAY-100635 (a 5-HT(1A) receptor antagonist, 0.3 mg/kg).	Methylene Chloride	34-49	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	260-277
19514753-4	2009	The HAp nanoparticle-coated PLLA microspheres were fabricated by the evaporation of CH(2)Cl(2) from the emulsion and characterized in terms of size, particle size distribution, and morphology using scanning/transmission electron microscopes.	Methylene Chloride	84-94	reticulon 3	Homo sapiens	4-7
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Methylene Chloride	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
19435638-2	2009	The organic carbon-normalized sorption coefficients (K(OC)) for diuron and phenanthrene (determined from single initial concentrations of 0.8mgL(-1) and 1.5mgL(-1), respectively) were consistently higher following solvent-conditioning of a whole soil with five organic solvents (acetonitrile, acetone, methanol, chloroform and dichloromethane).	Methylene Chloride	327-342	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	53-58
19435638-3	2009	The relative increase in K(OC) was inversely related to the polarity of the conditioning solvent (i.e. greater increases in K(OC) were observed for the least polar solvents: chloroform and dichloromethane).	Methylene Chloride	189-204	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	25-30
19435638-3	2009	The relative increase in K(OC) was inversely related to the polarity of the conditioning solvent (i.e. greater increases in K(OC) were observed for the least polar solvents: chloroform and dichloromethane).	Methylene Chloride	189-204	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	124-129
19319397-4	2009	Upon treatment with PI3 in CH2Cl2 solution, ligands 5-8 undergo redox reactions to furnish the triiodide salts of the corresponding phosphenium cations 13-16 which were characterized by 1H, 13C and 31P NMR, and MS-CI spectroscopy.	Methylene Chloride	27-33	peptidase inhibitor 3	Homo sapiens	20-23
19788064-5	2009	To confirm the protein bound volatiles, purified alpha2u was extracted with dichloromethane and volatile molecules were detected using of gas chromatography linked to mass spectrometry (GC-MS).	Methylene Chloride	76-91	alpha2u globulin	Rattus norvegicus	49-56
19173220-1	2009	The dichloromethane extract of the roots and heartwood of Caesalpinia sappan exhibited potent inhibitory activity against beta-hexosaminidase release as marker of degranulation in rat basophilic leukemic (RBL-2H3) cells, with inhibition of 98.7% and 87.5% at concentration of 100 microg/ml, respectively.	Methylene Chloride	4-19	O-GlcNAcase	Rattus norvegicus	122-141
19473794-8	2009	Strong cytotoxicity was shown by the methylene chloride extract of Michelia champaca bark and the methanol extract of Curcuma longa rhizome against C32 and HeLa, respectively.	Methylene Chloride	37-55	chemokine like factor	Homo sapiens	148-151
19421978-1	2009	Treatment of HC[triple bond]CC(CH3)(OH)CH=CH2 with [OsCl2(PPh3)3] in dichloromethane yielded the eta2-olefin-coordinated osmacycle [Os{CH=C(PPh3)C(=CH2)-eta2-CH=CH2}Cl2(PPh3)2] (9).	Methylene Chloride	69-84	DNA polymerase iota	Homo sapiens	97-101
19421978-1	2009	Treatment of HC[triple bond]CC(CH3)(OH)CH=CH2 with [OsCl2(PPh3)3] in dichloromethane yielded the eta2-olefin-coordinated osmacycle [Os{CH=C(PPh3)C(=CH2)-eta2-CH=CH2}Cl2(PPh3)2] (9).	Methylene Chloride	69-84	DNA polymerase iota	Homo sapiens	153-157
19441783-1	2009	When saccharides bearing a sulfur, selenium, or oxygen substituent at the anomeric center and an unprotected hydroxyl group either at C-4 or C-6 were subjected to fluorination with DAST in dichloromethane, a regioselective migration of the anomeric substituent to the C-4 or C-6 position was observed.	Methylene Chloride	189-204	complement C4A (Rodgers blood group)	Homo sapiens	268-271
19441783-1	2009	When saccharides bearing a sulfur, selenium, or oxygen substituent at the anomeric center and an unprotected hydroxyl group either at C-4 or C-6 were subjected to fluorination with DAST in dichloromethane, a regioselective migration of the anomeric substituent to the C-4 or C-6 position was observed.	Methylene Chloride	189-204	complement C6	Homo sapiens	275-278
19214306-2	2009	Both C-Cl bonds of CH(2)Cl(2) are readily activated by CoCl(2) and metallic Zn allowing quantitative methylation of phosphines; unprecedented zwitterionic Co(ii) and Zn(ii) intermediates have been characterized which display alpha-metallated phosphoniums.	Methylene Chloride	19-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-160
17971998-1	2007	The mechanism of the Baeyer-Villiger rearrangement is modelled for the reaction of propanone with trifluoroperacetic acid, catalyzed by trifluoroacetic acid in dichloromethane, using three DFT methods (B3LYP, BH&HLYP and MPWB1K) and MP2.	Methylene Chloride	160-175	tryptase pseudogene 1	Homo sapiens	237-240
19382570-3	2009	The formed complexes were extracted into dichloromethane, and their absorbance was measured at 403 and 410 nm for BCP and BPB, respectively.	Methylene Chloride	41-56	opsin 1, short wave sensitive	Homo sapiens	114-125
18515053-2	2008	Bovine serum albumin (BSA) and recombinant human growth hormone (rhGH) were homogeneously solubilized as nano-scale complexes in methylene chloride phase by using polyethylene glycol (PEG) as a complex-forming agent.	Methylene Chloride	129-147	growth hormone 1	Homo sapiens	49-63
18669019-5	2008	Also the dichloromethane fraction exhibited cytotoxic activity against COR-L23 (IC50 30.4 microg/ml) and C32 (IC50 33.2 microg/ml) cells, while the EtOAc fraction demonstrated a selective cytotoxic activity against MCF-7 cells (IC50 67.9 microg/ml).	Methylene Chloride	9-24	chemokine like factor	Homo sapiens	105-108
18179206-6	2008	Compound [(L1re)(Cl)FeII][Et4N]2 can be further oxidized to [(L1re-2)(Cl)FeIII][Et4N] by CH2Cl2.	Methylene Chloride	89-95	LINE1 retrotransposable element 2	Homo sapiens	62-68
17949767-4	2008	Subsequent reverse-phase high-performance liquid chromatography (RP-HPLC) of the dichloromethane/methanol (1/1) fraction separated contaminants potent in the TR and Luc assays from those potent in the TTR assay.	Methylene Chloride	81-96	transthyretin L homeolog	Xenopus laevis	201-204
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	109-114
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	156-161
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-160
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	104-107
18097493-11	2008	Cyclic voltammetry experiments in MeCN-CH2Cl2 reveal facile metal-centred reversible-to-quasireversible CoIV-CoIII (or a ligand-centred redox process; 2a), CoIII-CoII (1a, 1b.MeOH, 2a, 2b and 3), CoII-CoI (1a, 1b.MeOH, 2aand 2b), and CoI-Co0 (1a, 1b.MeOH and 2b) redox processes.	Methylene Chloride	39-45	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	109-112
18190207-6	2008	When methylene chloride is used as the solvent, it forms analogous domains on the surface at 77 K. Mild annealing under vacuum causes most toluene molecules to desorb from the surface; however, this annealing process may lead to thermal degradation of Ru2 molecules.	Methylene Chloride	5-23	doublecortin domain containing 2	Homo sapiens	252-255
18020445-2	2007	The sodium salt of the Hhpp ligand, Hhpp = 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine, a 6,6 bicyclic, guanidine system, reacts with (THT)AuCl (THT = tetrahydrothiophene) in THF or CH2Cl2 to form the Au(II) complex, [Au2(hpp)2Cl2].	Methylene Chloride	189-195	HHPP	Homo sapiens	23-27
19707315-5	2007	We observed that only the DCM fraction ST-2 inhibited cell growth and viability in a dose-dependent manner.	Methylene Chloride	26-29	ST2	Homo sapiens	39-43
18952040-3	2009	After enzymatic reaction of human serum paraoxonase (PON1) with nerve gas, substrate was removed with dichloromethane, and alkyl methylphoshphonates were quantified by capillary electrophoresis of reversed osmotic flow using cationic detergent and sorbic acid.	Methylene Chloride	102-117	paraoxonase 1	Homo sapiens	53-57
19728301-1	2009	The present report regards a computational study aimed at assessing the conformational profile of the four stereoisomers of the peptide Ace-Pro-c3Phe-NMe, previously reported to exhibit beta-turn structures in dichloromethane with different type I/type II beta-turn profiles.	Methylene Chloride	210-225	angiotensin I converting enzyme	Homo sapiens	136-139
18621111-4	2008	The results indicated that among the three extracts, i.e. the ethanolic extract (PM1), the water extract (PM2) and dichloromethane extract (PM3), PM3 exhibited the most potent estrogenic activity in both models, followed by PM1.	Methylene Chloride	115-130	transmembrane protein 11	Homo sapiens	224-227
18774789-1	2008	Anharmonic and related constants have been calculated for CH2Cl2, CD2Cl2, and CHDCl2 by using the program Gaussian03 and B3LYP and MP2 models.	Methylene Chloride	58-64	tryptase pseudogene 1	Homo sapiens	131-134
18766238-2	2008	The SERRS spectra of an Ag island film spin coated with 50 microL of a 8.7 x 10(-7) M of CLPTCD in CH2Cl2 excited at 514.5 nm show signals from the first to the third overtones and combinations of fundamental vibrational modes observed between 1200 and 1600 cm(-1).	Methylene Chloride	99-105	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-9
18666761-3	2008	For the compound with n = 4 (DBA4), analysis of dipole signals indicates that the effective charge separation distances in toluene, 1,4-dioxane, ethyl acetate, tetrahydrofuran, dichloromethane, 1,2-dichloroethane, 2-methylpentanone-3, 3-pentanone, and benzonitrile are 2.2, 2.5, 4.5, 4.7, 5.5, 5.5, 4.8, and 6.3 A, respectively.	Methylene Chloride	177-192	ribosomal protein S17	Homo sapiens	29-33
18642814-2	2008	The oxidation of alkanes by various peroxides ((t)BuOOH, H2O2, PhCH2C(CH3)2OOH) is efficiently catalyzed by [Os(VI)(N)Cl4](-)/Lewis acid (FeCl3 or Sc(OTf)3) in CH2Cl2/CH3CO2H to give alcohols and ketones.	Methylene Chloride	160-166	POU class 5 homeobox 1	Homo sapiens	147-155
18506227-1	2008	Oxidative additions of dichloromethanes to a diiridium(i) core, bridged by 2-ferrocenyl-1,8-naphthyridines (NP-Fc), provide an iridium(II) dimer, [IrCl2(CO)2(eta 1-NP-Fc)]2, featuring an unsupported Ir-Ir single bond (2.7121(8) A).	Methylene Chloride	23-39	secreted phosphoprotein 1	Homo sapiens	158-163
18236442-1	2008	Interaction of H3O+ or H5O2+ with 1,3-alternate tetrapropoxycalix[4]arene (1) was studied in nitrobenzene and dichloromethane using 1H and 13C NMR including transverse and rotating-frame relaxations and density functional level of theory (DFT) quantum calculations.	Methylene Chloride	110-125	H3 clustered histone 15	Homo sapiens	15-18
18198868-5	2008	Adsorption is promoted by scanning to positive potentials (through the ferrocene wave) and by high concentrations of Bu4N+ X- electrolyte (X- = ClO4(-), PF6(-)) in the CH2Cl2 solvent; there is no adsorption if X- = p-toluenesulfonate or if the electrode is coated with an alkanethiolate monolayer.	Methylene Chloride	168-174	sperm associated antigen 17	Homo sapiens	153-156
18472637-5	2008	The annexin V, as well as the uptake of fluorescein diacetate/propidium iodide staining, revealed that methanolic and methane dichloride extracts of L. divaricata treatment of cells resulted in a rapid plasma membrane perturbation and triggered cellular death (>70%).	Methylene Chloride	118-136	annexin A5	Homo sapiens	4-13
17958423-8	2007	A CH2Cl2 solution under 0.30 atm of H2 and 0.13 atm of O2 converted to H2O in the presence of 1 and 10 mol % of H(OEt2)2BAr(F)4 (BAr(F)4- = B(C6H3-3,5-(CF3)2)4-).	Methylene Chloride	2-8	relaxin 2	Homo sapiens	36-44
17713902-2	2007	Isolable copper(I) complexes of the type [(BIT(OR,SMe))Cu(CO)]PF6 (3a and 3b) are produced in reactions of the respective tripodal ligands 1a (R = H) and 1b (R = Me) with [Cu(CH3CN)4]PF6 in CH2Cl2 under CO (1 atm); the pyramidal structure of 3a has been determined crystallographically.	Methylene Chloride	190-196	sperm associated antigen 17	Homo sapiens	62-65
17927182-2	2007	The binding constants (Ka11) of the BF2 complexes (3a-c) for various anions (Cl-, Br-, CH3CO2-, H2PO4-, and HSO4-) in CH2Cl2 decrease in the order Ph (3a) > o-tolyl (3b) > 2,6-Me2Ph (3c), possibly because of differences in the planarity and the number of interacting o-CH units at the binding sites.	Methylene Chloride	118-124	forkhead box G1	Homo sapiens	36-39
17620348-0	2007	Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation.	Methylene Chloride	85-100	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	21-27
17620348-1	2007	Dichloromethane (DCM) is metabolically converted to carbon monoxide mostly by CYP2E1 in liver, resulting in elevation of blood carboxyhemoglobin (COHb) levels.	Methylene Chloride	0-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	78-84
17424944-6	2007	These results indicate that the dichloromethane extract of PBL includes anticancer components composed of at least three fatty acids, and apoptosis-inducing activity of the extract was mediated by caspase-3 activation in tumor cells.	Methylene Chloride	32-47	caspase 3	Mus musculus	197-206
17592598-5	2007	In chlorinated solvents such as dichloromethane or chloroform, [5]PF(6) rapidly abstracts chloride by reductive dechlorination of the solvent to yield [(TL(tBu))CuCl]PF6, [8]PF6 quantitatively.	Methylene Chloride	32-47	sperm associated antigen 17	Homo sapiens	166-169
17592598-5	2007	In chlorinated solvents such as dichloromethane or chloroform, [5]PF(6) rapidly abstracts chloride by reductive dechlorination of the solvent to yield [(TL(tBu))CuCl]PF6, [8]PF6 quantitatively.	Methylene Chloride	32-47	sperm associated antigen 17	Homo sapiens	174-177
17439239-1	2007	The aim of this study was to investigate whether a cationic polyelectrolyte, poly(ethylene glycol)-b-poly(L-histidine) diblock copolymer (PEG-polyHis), can stabilize insulin, at the aqueous/methylene chloride interface formed during the microencapsulation process.	Methylene Chloride	190-208	insulin	Homo sapiens	166-173
17497810-2	2007	The self-assembled monolayers of RhCl(CO)(PPh3)2 are prepared from either dichloromethane or aqueous solutions, but the ordered structures are observed only in atmospheric conditions after solvents evaporate.	Methylene Chloride	74-89	protein phosphatase 4 catalytic subunit	Homo sapiens	42-46
17426864-1	2007	Reaction of [ReOCl3(PPh3)(2)] with HCpz(3) (pz = pyrazole) in dichloromethane leads to the formation of a new Re(iv) complex [ReCl3(HCpz3)]X (X=Cl, [ReO4]) with loss of the rhenium-oxo group.	Methylene Chloride	62-77	caveolin 1	Homo sapiens	20-24
16872891-2	2007	Charge-transfer (CT) complexes of carbazole, N-ethylcarbazole and 1,n-di(N-carbazolyl)alkanes with p-chloranil (p-CHL) have been investigated spectrophotometrically in dichloromethane.	Methylene Chloride	168-183	chordin like 1	Homo sapiens	114-117
17602615-2	2007	Addition of [CuCl(PPh3)]4 and Tl[PF6] to a CH2Cl2 solution of 1a results in simple cation replacement, forming the analogous [Cu(PPh3)3]+ salt (1b).	Methylene Chloride	43-49	protein phosphatase 4 catalytic subunit	Homo sapiens	18-22
17602615-2	2007	Addition of [CuCl(PPh3)]4 and Tl[PF6] to a CH2Cl2 solution of 1a results in simple cation replacement, forming the analogous [Cu(PPh3)3]+ salt (1b).	Methylene Chloride	43-49	protein phosphatase 4 catalytic subunit	Homo sapiens	129-133
17503848-3	2007	The thermal syn-addition of these sulfenic acids onto the triple bonds of the unsaturated acceptors was conducted in CH2Cl2 at 40 degrees C. The concentration of sulfoxide precursors of sulfenic acid and the sulfoxide/acceptor molar ratio addressed the syn-addition toward open-chain benzene sulfoxides or thiacyclophane S-oxides.	Methylene Chloride	117-123	synemin	Homo sapiens	12-15
17419620-1	2007	The slow hydrolysis of B(OMe)3 in a CH2Cl2 solution in the presence of 1,8-C10H6(NMe2)2 (5:1 ratio) led to the formation of the novel isolated pentaborate ester anion [B5O6(OMe)4]-, which was characterized by a single-crystal X-ray diffraction study as the salt [1,8-C10H6(NMe2)2H][B5O6(OMe)4].	Methylene Chloride	36-42	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	273-277
17362000-3	2007	By contrast, the reaction carried out in dichloromethane led to [Ti[micro-N,O-NTs]Cl(NMe2)(NHMe2)2]2 (3) and [Ti[micro-N,O-NTs]Cl2(NHMe2)2]n (4) through solvent activation.	Methylene Chloride	41-56	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	85-89
16765633-0	2006	Induction of DNA-protein crosslinks by dichloromethane in a V79 cell line transfected with the murine glutathione-S-transferase theta 1 gene.	Methylene Chloride	39-54	glutathione S-transferase, theta 1	Mus musculus	102-135
17252111-1	2007	The reaction of PdCl2, dppm and CS2 in CH(2)Cl(2)/MeOH results in the palladium carbodiphosphorane complex [Pd(Ph(2)PCH(2)Ph(2)PCPPh(2)CH(2)PPh(2)-P,C,P)Cl]Cl.	Methylene Chloride	39-49	chorionic somatomammotropin hormone 2	Homo sapiens	32-35
17907122-3	2007	However, when the reaction was carried out in acetone or dichloromethane a dinuclear eta(6)-arene Rh(II) complex (5) was obtained in the absence of added redox reagents.	Methylene Chloride	57-72	Rh blood group D antigen	Homo sapiens	98-103
19002880-6	2006	Specific production rates of interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha) from T cell were higher as 1.16 x 10(-4) and 1.86 x 10(-4 )pg/cell, respectively, in the purified compound, compared to 1.38 x 10(-4) and 2.22 x 10(-4 )pg/cell, respectively, by adding 0.5 g/L of the dichloromethane fraction.	Methylene Chloride	288-303	interleukin 6	Homo sapiens	29-42
19002880-6	2006	Specific production rates of interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha) from T cell were higher as 1.16 x 10(-4) and 1.86 x 10(-4 )pg/cell, respectively, in the purified compound, compared to 1.38 x 10(-4) and 2.22 x 10(-4 )pg/cell, respectively, by adding 0.5 g/L of the dichloromethane fraction.	Methylene Chloride	288-303	interleukin 6	Homo sapiens	44-48
19002880-6	2006	Specific production rates of interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha) from T cell were higher as 1.16 x 10(-4) and 1.86 x 10(-4 )pg/cell, respectively, in the purified compound, compared to 1.38 x 10(-4) and 2.22 x 10(-4 )pg/cell, respectively, by adding 0.5 g/L of the dichloromethane fraction.	Methylene Chloride	288-303	tumor necrosis factor	Homo sapiens	77-86
16874663-3	2006	Typical substrates for GSTT1 are industrial compounds, such as dichloromethane and ethylene oxide.	Methylene Chloride	63-78	glutathione S-transferase theta 1	Homo sapiens	23-28
17085293-2	2006	The methylene chloride soluble fraction of methanol extract from the stems of S. japonica showed significant MMP-1 inhibition in primary old aged human skin fibroblasts caused by ultraviolet (UV) irradiation.	Methylene Chloride	4-22	matrix metallopeptidase 1	Homo sapiens	109-114
17249732-7	2007	X-ray crystal structures of 23.2.5MeOH, 23.1.5MeCN, 24.CH2Cl2, and 24.1.5CH2Cl2 show the saddle-shape folding (typical of ex-TTF derivatives), which in 24 is enhanced by the pentamethylene chain bridging the dithiole units.	Methylene Chloride	55-61	ras homolog family member H	Homo sapiens	125-128
17200758-4	2007	One-electron oxidation of 2 in CH(2)Cl(2) under argon with one equiv of NOBF4 affords diamagnetic [Pd(L(N,O)(IBQ))((t)bpy)](PF6)(BF4).2CH(2)Cl(2) (3).	Methylene Chloride	31-41	sperm associated antigen 17	Homo sapiens	124-127
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Methylene Chloride	56-64	protein phosphatase 4 catalytic subunit	Homo sapiens	78-82
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Methylene Chloride	56-64	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Methylene Chloride	56-64	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Methylene Chloride	56-64	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Methylene Chloride	56-64	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
16999416-8	2006	cis-[(PPh3)2Pt(mu-OH)]2(NO3)2 reacts with 1-MeCy, in DMSO or CH2Cl2, to give the mononuclear species cis-[(PPh3)2Pt{1-MeCy(-H)}(1-MeCy)](NO3) (4) containing one neutral and one NH2-deprotonated 1-MeCy molecule, coordinated to the same metal center at the N3 and N4 sites, respectively.	Methylene Chloride	61-67	caveolin 1	Homo sapiens	6-10
16999416-8	2006	cis-[(PPh3)2Pt(mu-OH)]2(NO3)2 reacts with 1-MeCy, in DMSO or CH2Cl2, to give the mononuclear species cis-[(PPh3)2Pt{1-MeCy(-H)}(1-MeCy)](NO3) (4) containing one neutral and one NH2-deprotonated 1-MeCy molecule, coordinated to the same metal center at the N3 and N4 sites, respectively.	Methylene Chloride	61-67	caveolin 1	Homo sapiens	107-111
16765633-9	2006	After DCM treatment a significant concentration-dependent increase in tail moment in the V79 MZ cells was observed compared to a significant concentration-dependent decrease in tail moment in the V79 mGSTT1 cells.	Methylene Chloride	6-9	glutathione S-transferase, theta 1	Mus musculus	200-206
16765633-11	2006	DCM formed significantly higher levels of formaldehyde in the cytosol of the V79 mGSTT1 cells than in the cytosol of the V79 MZ cells.	Methylene Chloride	0-3	glutathione S-transferase, theta 1	Mus musculus	81-87
16765633-13	2006	These results indicate that V79 mGSTT1 can metabolize DCM to a genotoxic and cytotoxic metabolite, which is likely formaldehyde.	Methylene Chloride	54-57	glutathione S-transferase, theta 1	Mus musculus	32-38
16939272-9	2006	Activation energies for the stereogenic step have been determined by calculation of the transition state and substrate structures in dichloromethane solution at the B3LYP/6-311+G(2d,p)//B3LYP/6-31+G(d) level of theory in dichloromethane solution.	Methylene Chloride	133-148	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	167-170
16715514-6	2006	Nonconventional dichloromethane-based eluents have permitted to expand the chiral resolving ability of the immobilized Chiralpak IA CSP and to perform mg-scale enantioseparations with an analytical-size column.	Methylene Chloride	16-31	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	132-135
16895423-8	2006	Crystals of 12 grown from CH2Cl2 were found to contain a dimer, [U(NPh)2(OTf)2(THF)2]2, a complex possessing bridging triflate groups.	Methylene Chloride	26-32	POU class 2 homeobox 2	Homo sapiens	73-78
16562956-4	2006	The reaction of 1Cl or 1H with O2 at -78 degrees C in CH2Cl2 gives UV-vis and resonance Raman spectra indicative of a mu-eta2:eta2-(side-on)-peroxo dicopper(II) adduct (2R).	Methylene Chloride	54-60	DNA polymerase iota	Homo sapiens	126-130
16808512-3	2006	On the other hand, when the reaction was carried out in the presence of a catalytic amount of Cu(NTf2)2 and 1 equiv of H2O in (CH2Cl)2 at 100 degrees C, the decarbonylated naphthalene products 4 were obtained selectively over 3.	Methylene Chloride	126-134	nuclear transport factor 2	Homo sapiens	97-101
16800573-1	2006	The supported clusters Pt-Ru/gamma-Al2O3 were prepared by adsorption of the bimetallic precursor Pt3Ru6(CO)21(mu3-H)(mu-H)3 from CH2Cl2 solution onto gamma-Al2O3 followed by decarbonylation in He at 300 degrees C. The resultant supported clusters were characterized by infrared (IR) and extended X-ray absorption fine structure (EXAFS) spectroscopies and as catalysts for ethylene hydrogenation and n-butane hydrogenolysis.	Methylene Chloride	129-135	familial progressive hyperpigmentation 1	Homo sapiens	117-123
16387530-2	2006	Charge transfer (CT) complexes of anthracene, 9-methylanthracene and 1,n-di(9-anthryl)alkanes with p-chloranil (p-CHL) have been investigated spectrophotometrically in dichloromethane.	Methylene Chloride	168-183	chordin like 1	Homo sapiens	114-117
16779580-17	2006	A viscous hydrocarbon paste uncovered in API 1 was insoluble in water but dissolved in dichloromethane.	Methylene Chloride	87-102	baculoviral IAP repeat containing 2	Homo sapiens	41-46
16602793-3	2006	A three-component reaction involving ArP(O)(OH)2, 3,5-dimethylpyrazole(DMPZH), and Cu(CH3COO)2.H2O produces the tetranuclear Cu(II) compound [Cu4(mu3-OH)2{ArPO2(OH)}2(CH3CO2)2(DMPZH)4][CH3COO]2.CH2Cl2 (3).	Methylene Chloride	194-200	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	37-40
16562956-4	2006	The reaction of 1Cl or 1H with O2 at -78 degrees C in CH2Cl2 gives UV-vis and resonance Raman spectra indicative of a mu-eta2:eta2-(side-on)-peroxo dicopper(II) adduct (2R).	Methylene Chloride	54-60	DNA polymerase iota	Homo sapiens	121-125
16171358-3	2005	Two reversible, surface-confined redox couples were obtained for the fullerene-containing SAMs on TMF/GCE in CH(2)Cl(2) solution.	Methylene Chloride	109-119	methionine adenosyltransferase 1A	Homo sapiens	90-94
16509630-7	2006	The rest react with pentane with the bimolecular rate constants k(bi) = (9.5 +/- 0.7) x 10(9) M(-1) s(-1) in CH2Cl2 and k(bi) = (7.4 +/- 2) x 10(9) M(-1) s(-1) in CCl4.	Methylene Chloride	109-115	C-C motif chemokine ligand 4	Homo sapiens	163-167
16506751-2	2006	Electron-deficient alkenes, p-X-trans-beta-nitrostyrene (X = OCH3, CH3, H, F, Br, CF3, NO2), react quantitatively with (bc)Pd(eta2-O2) (bc = bathocuproine) in dichloromethane at room temperature to form the corresponding palladium(0)-alkene complexes.	Methylene Chloride	159-174	DNA polymerase iota	Homo sapiens	126-133
16365908-4	2006	We provide evidence that the active ingredient of the Ag+/PX3 reagent is the (H2CCl2)Ag-X-PX2+ cation.	Methylene Chloride	78-84	pannexin 3	Homo sapiens	58-61
16365908-4	2006	We provide evidence that the active ingredient of the Ag+/PX3 reagent is the (H2CCl2)Ag-X-PX2+ cation.	Methylene Chloride	78-84	pannexin 2	Homo sapiens	90-93
16246350-3	2006	The optimized method of separation is used for an online HPLC monitoring for the Rh(II)-catalyzed asymmetric intermolecular cyclopropanations in dichloromethane.	Methylene Chloride	145-160	Rh blood group D antigen	Homo sapiens	81-86
16892730-1	2006	The objective of this project was to study the effect of the presence of co-solvents with dichloromethane on the properties of leu-enkephalin microcapsules.	Methylene Chloride	90-105	prodynorphin	Homo sapiens	127-141
15950527-2	2005	The UV/vis absorption and fluorescent emission spectra of P1 and P2, measured in three solvents (acetonitrile, dichloromethane and toluene), reveal that the photophysical behaviors are closely related to silver (I) fragment, and strongly dependent on solvent polarity.	Methylene Chloride	111-126	crystallin gamma F, pseudogene	Homo sapiens	58-67
16568972-1	2006	Structural-functional analogue of the reduced site of dissimilatory nitrate reductase is synthesized as [Et4N][MoIV(SPh)(PPh3)(mnt)2].CH2Cl2 (1).	Methylene Chloride	134-140	caveolin 1	Homo sapiens	121-125
16568972-6	2006	The corresponding chloro complex, [Et4N][MoIV(Cl)(PPh3)(mnt)2].CH2Cl2 (2), responds to similar PPh3 dissociation but is unable to react with nitrate, showing the indispensable role of thiolate coordination for such oxotransfer reaction.	Methylene Chloride	63-69	caveolin 1	Homo sapiens	50-54
16568972-6	2006	The corresponding chloro complex, [Et4N][MoIV(Cl)(PPh3)(mnt)2].CH2Cl2 (2), responds to similar PPh3 dissociation but is unable to react with nitrate, showing the indispensable role of thiolate coordination for such oxotransfer reaction.	Methylene Chloride	63-69	caveolin 1	Homo sapiens	95-99
16529490-4	2006	Protonation of 3 using CF3SO3H in CH2Cl2 gives the charge-compensated compound [4,9-{Fe(CO)4}-4-(mu-H)-9,9,9-(CO)3-arachno-9,6-FeCB8H11] (6), in which the B-Fe sigma bond of the precursor has been converted to a B-H right harpoon-up Fe linkage.	Methylene Chloride	34-40	FECB	Homo sapiens	127-131
16499385-8	2006	Red-brown cis-TpiPrMoO2(SR) (R = as above and tBu) are formed by metathesis of TpiPrMoO2Cl and HSR/NEt3 in dichloromethane.	Methylene Chloride	107-122	HSR	Homo sapiens	95-98
16499385-8	2006	Red-brown cis-TpiPrMoO2(SR) (R = as above and tBu) are formed by metathesis of TpiPrMoO2Cl and HSR/NEt3 in dichloromethane.	Methylene Chloride	107-122	tetraspanin 2	Homo sapiens	99-103
16508179-2	2006	The CH2Cl2/MeOH extract of the stem bark of Oriciopsis glaberrima ENGL.	Methylene Chloride	4-10	exo/endonuclease G	Homo sapiens	66-70
16241143-5	2005	The [CpRh(Q)Cl] complexes react with PPh(3) in dichloromethane yielding the adducts CpRh(Q)Cl/PPh(3) (1:1) which exist in solution in two different isomeric forms.	Methylene Chloride	47-62	protein phosphatase 4 catalytic subunit	Homo sapiens	37-43
16241143-5	2005	The [CpRh(Q)Cl] complexes react with PPh(3) in dichloromethane yielding the adducts CpRh(Q)Cl/PPh(3) (1:1) which exist in solution in two different isomeric forms.	Methylene Chloride	47-62	protein phosphatase 4 catalytic subunit	Homo sapiens	94-100
16212342-2	2005	The X-ray structure of 1 grown in dichloromethane shows square-pyramidal coordination around the Co(II) ion, displaying a 1D polymeric network.	Methylene Chloride	34-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
16417034-7	2005	In contrast, the HRF predicted that the human carcinogenic potential of dichloromethane was at best less likely than in rodents; this conclusion was supported by the available epidemiological data.	Methylene Chloride	72-87	tumor protein, translationally-controlled 1	Homo sapiens	17-20
16117501-2	2005	Pretreatment of alpha-fluoropropiophenone with TiCl4 followed by reduction with LiBH4 in diethyl ether or methylene chloride provided the syn diastereomer predominantly, while use of Ti(OiPr)4 under identical conditions provided the anti diastereomer as the major product.	Methylene Chloride	106-124	synemin	Homo sapiens	138-141
15921820-4	2005	Both DCM and PE extracts had strong binding affinity to the 5-HT(5a) receptor, but only weak binding affinity to the 5-HT(2b) and the serotonin transporter.	Methylene Chloride	5-8	5-hydroxytryptamine receptor 5A	Homo sapiens	60-67
15740113-1	2005	Treatment of the allenylcarbene complex OsCl2(=CPh-CH=C=CHPh)(PPh3)2 with (PPh3)AuCCR in the presence of HNEt3Cl in CH2Cl2 produces osmabenzynes Os(CC(R)=C(CH2Ph)CH=CPh)Cl2(PPh3)2.	Methylene Chloride	116-122	caveolin 1	Homo sapiens	62-66
15998045-3	2005	The reaction of soluble complexes 3 and 4 with 2 equiv of Ph3P=CHCO2Me in CH2Cl2 (40 degrees C, 5 h) leads to dehydrochlorination resulting in a chelate ring closure to furnish the platinum(IV) chelates [PtCl2{NH=C(R)NC(Ph)=NPh}2] (R = Ph, 5; R = NEt2, 6), accordingly, and the phosphonium salt [Ph3PCH2CO2Me]Cl.	Methylene Chloride	74-80	tetraspanin 12	Homo sapiens	247-251
15962962-5	2005	Complex 5 x (1/2)CH2Cl2 crystallizes in the monoclinic space group P2(1)/c and contains two [Mn3(mu3-O)]7+ units linked at two of their apexes by two Pe(t)CO2(-) ligands and one mu4-CH2O2(2-) bridge.	Methylene Chloride	17-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	67-72
15911045-5	2005	PEGylated insulin can be co-dissolved with PLGA in methylene chloride and microspheres made by a single o/w emulsion process.	Methylene Chloride	51-69	insulin	Homo sapiens	10-17
15683365-3	2005	Murine GST T1-1 is particularly active with dichloromethane, which may explain the high carcinogenicity of dichloromethane in the mouse.	Methylene Chloride	44-59	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	11-15
15683365-3	2005	Murine GST T1-1 is particularly active with dichloromethane, which may explain the high carcinogenicity of dichloromethane in the mouse.	Methylene Chloride	107-122	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	11-15
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Methylene Chloride	16-22	transcription factor Dp-1	Homo sapiens	24-27
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Methylene Chloride	16-22	transcription factor Dp-1	Homo sapiens	158-161
15783196-5	2005	The macrocyclic nitrogen subsequently attacks the methylene chloride with a classic SN2 trajectory, and although the carbon-chlorine bond breaks, the chloride leaving group does not separate from the newly formed cationic macrocycle, such that the product is a tightly associated ion-pair.	Methylene Chloride	50-68	solute carrier family 38 member 5	Homo sapiens	84-87
15740879-8	2005	After 41 days of DCM extract administration at a dose of 300 mg/kg/day, diabetic rats showed improvement in glycemia, body weight, triglycerides, and GPT in comparison with the diabetic control group.	Methylene Chloride	17-20	glutamic--pyruvic transaminase	Rattus norvegicus	150-153
16241161-5	2005	The addition of these metal ions to dichloromethane solutions of L1, L2, and L3 produce strong changes in the absorption and emission spectra of these ligands.	Methylene Chloride	36-51	L1 cell adhesion molecule	Homo sapiens	65-79
15909046-2	2005	The heating of a solution of [Ru(eta(1)-1,2-S2B6H9)(PPh3)2(eta5-Cp)] 2 in CH2Cl2 at reflux temperature afforded 1 in 59% yield.	Methylene Chloride	74-80	protein phosphatase 4 catalytic subunit	Homo sapiens	52-56
15907139-4	2005	Complex 3-Nd1 can also be obtained from the treatment of complex 2 with DOTf in dichloromethane.	Methylene Chloride	80-95	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	10-13
15752741-4	2005	Films of collagen:PCL biocomposites were prepared using non-crosslinking method by impregnation of lyophilized collagen mats with PCL/dichloromethane solutions followed by solvent evaporation.	Methylene Chloride	134-149	PHD finger protein 1	Homo sapiens	18-21
15796509-1	2005	The first example of a stable oxoborane monomer (LB=O) stabilized by complexation to AlCl3 has been prepared by the reaction of LAlCl2 with BCl3 followed by treatment with H2O in CH2Cl2 (L = [HC(CMe)2(NC6F5)2]).	Methylene Chloride	179-185	BCL3 transcription coactivator	Homo sapiens	140-144
15740113-1	2005	Treatment of the allenylcarbene complex OsCl2(=CPh-CH=C=CHPh)(PPh3)2 with (PPh3)AuCCR in the presence of HNEt3Cl in CH2Cl2 produces osmabenzynes Os(CC(R)=C(CH2Ph)CH=CPh)Cl2(PPh3)2.	Methylene Chloride	116-122	caveolin 1	Homo sapiens	75-79
15740113-1	2005	Treatment of the allenylcarbene complex OsCl2(=CPh-CH=C=CHPh)(PPh3)2 with (PPh3)AuCCR in the presence of HNEt3Cl in CH2Cl2 produces osmabenzynes Os(CC(R)=C(CH2Ph)CH=CPh)Cl2(PPh3)2.	Methylene Chloride	116-122	caveolin 1	Homo sapiens	75-79
15733006-7	2005	cis-[Ru(o-C6H4-2-py)(bpy)(MeCN)2]PF6 (2e) has been prepared in CH2Cl2 (74%).	Methylene Chloride	63-69	sperm associated antigen 17	Homo sapiens	33-36
15732997-1	2005	Complexes (R3P)2PtF2 were prepared by reaction of the corresponding diiodo precursors with AgF in dichloromethane.	Methylene Chloride	98-113	angiopoietin like 6	Homo sapiens	91-94
15859286-2	2005	The reaction of [Re(MeCN)Cl3(PPh3)2] with [Ag(L1OH)(L1O)] in cold dichloromethane-acetonitrile solvent has furnished the green colored ionized azoimine complex [ReV(O)Cl(PPh3)2(L1)](PF6), 2.	Methylene Chloride	66-81	protein phosphatase 4 catalytic subunit	Homo sapiens	29-33
15859286-2	2005	The reaction of [Re(MeCN)Cl3(PPh3)2] with [Ag(L1OH)(L1O)] in cold dichloromethane-acetonitrile solvent has furnished the green colored ionized azoimine complex [ReV(O)Cl(PPh3)2(L1)](PF6), 2.	Methylene Chloride	66-81	protein phosphatase 4 catalytic subunit	Homo sapiens	170-174
15859286-2	2005	The reaction of [Re(MeCN)Cl3(PPh3)2] with [Ag(L1OH)(L1O)] in cold dichloromethane-acetonitrile solvent has furnished the green colored ionized azoimine complex [ReV(O)Cl(PPh3)2(L1)](PF6), 2.	Methylene Chloride	66-81	sperm associated antigen 17	Homo sapiens	182-185
15316986-5	2004	Dehydrohalogenation of [Cp*IrCl2(PH2Ar)] in CH2Cl2 at low temperatures resulted in the novel fused-ring systems 17 (Ar=Mes*) and 20 (Ar=Mes), with dimeric [[Cp*Ir=PAr]2] being the likely intermediate.	Methylene Chloride	44-50	F2R like trypsin receptor 1	Homo sapiens	163-168
15501612-8	2004	A comparison of the observed variation in V(maxC) values to other estimates of variability in the rate of oxidative metabolism and human CYP2E1 activity suggest a relatively narrow range in human hepatic activity toward DCM.	Methylene Chloride	220-223	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	137-143
18969645-9	2004	Low levels of dichloromethane and chloroform ranging from 0.04 to 1.13mugg(-1) were found in samples obtained from small gardens irrigated with tap water.	Methylene Chloride	14-29	nuclear RNA export factor 1	Homo sapiens	144-147
15315452-4	2004	Compared to the Co complexes 9, Co4, and Co1, the first oxidation of Co3 is considerably shifted to more positive potentials, if benzonitrile instead of dichloromethane is used as solvent.	Methylene Chloride	153-168	complement C4A (Rodgers blood group)	Homo sapiens	32-35
15642010-7	2004	The substances causing EAG activity could be removed partially by dichloromethane, ethanol and pentane-ether.	Methylene Chloride	66-81	potassium voltage-gated channel subfamily H member 1	Homo sapiens	23-26
15554639-4	2004	Ru2(dpf)4(NO) undergoes reversible one-electron reductions under N2 at E1/2=0.06 and -1.24 V in CH2Cl2, 0.1 M TBABr.	Methylene Chloride	96-102	doublecortin domain containing 2	Homo sapiens	0-3
15554639-7	2004	Ru2(dpf)4(NO)2 displays a reversible one-electron reduction at E1/2=-1.24 V versus SCE and an irreversible reduction at Epc=-1.96 V in CH2Cl2, 0.1 M TBAP under N2.	Methylene Chloride	135-141	doublecortin domain containing 2	Homo sapiens	0-3
15554639-7	2004	Ru2(dpf)4(NO)2 displays a reversible one-electron reduction at E1/2=-1.24 V versus SCE and an irreversible reduction at Epc=-1.96 V in CH2Cl2, 0.1 M TBAP under N2.	Methylene Chloride	135-141	enhancer of polycomb homolog 1	Homo sapiens	120-126
15486963-4	2004	While in contrast to ferritin overexpression, single administration of the CO donor methylene chloride (MC) or of BV also protected mice from liver damage, only coadministration of both HO products prolonged survival and reduced the expression of cytokines, e.g., tumor necrosis factor (TNF) and interferon gamma (IFN-gamma).	Methylene Chloride	104-106	tumor necrosis factor	Mus musculus	264-285
15486963-4	2004	While in contrast to ferritin overexpression, single administration of the CO donor methylene chloride (MC) or of BV also protected mice from liver damage, only coadministration of both HO products prolonged survival and reduced the expression of cytokines, e.g., tumor necrosis factor (TNF) and interferon gamma (IFN-gamma).	Methylene Chloride	104-106	tumor necrosis factor	Mus musculus	287-290
15486963-4	2004	While in contrast to ferritin overexpression, single administration of the CO donor methylene chloride (MC) or of BV also protected mice from liver damage, only coadministration of both HO products prolonged survival and reduced the expression of cytokines, e.g., tumor necrosis factor (TNF) and interferon gamma (IFN-gamma).	Methylene Chloride	104-106	interferon gamma	Mus musculus	296-323
15554262-1	2004	Thirteen compounds were isolated from the CH2Cl2 fraction of Machilus thunbergii as phospholipase Cgamma1 (PLCgamma1) inhibitors.	Methylene Chloride	42-48	phospholipase C gamma 1	Homo sapiens	107-116
15490317-1	2004	In the course of a screening of plant extracts for potential CNS and anti-inflammatory activities, a dichloromethane extract of Salvia miltiorrhiza showed a pronounced inhibitory effect on recombinant monoamine oxidase A (MAO A) and on inducible NO synthase (iNOS) induction in Raw 267.4 cells.	Methylene Chloride	101-116	monoamine oxidase A	Homo sapiens	222-227
14601832-8	2003	The response was greatly increased by post-column addition of 1% (v/v) triethylamine and its equivalent amount of formic acid in dichloromethane introduced at 0.1 ml min(-1) into the mobile phase.	Methylene Chloride	129-144	CD59 molecule (CD59 blood group)	Homo sapiens	166-172
15490317-1	2004	In the course of a screening of plant extracts for potential CNS and anti-inflammatory activities, a dichloromethane extract of Salvia miltiorrhiza showed a pronounced inhibitory effect on recombinant monoamine oxidase A (MAO A) and on inducible NO synthase (iNOS) induction in Raw 267.4 cells.	Methylene Chloride	101-116	nitric oxide synthase 2	Homo sapiens	259-263
15252617-1	2004	[Cp*Rh(eta1-NO3)(eta2-NO3)] (1) reacted with pyrazine (pyz) to give a dinuclear complex [Cp*Rh(eta1-NO3)(mu-pyz)(0.5)]2.CH2Cl2(3.CH2Cl2).	Methylene Chloride	120-126	secreted phosphoprotein 1	Homo sapiens	7-11
15252617-1	2004	[Cp*Rh(eta1-NO3)(eta2-NO3)] (1) reacted with pyrazine (pyz) to give a dinuclear complex [Cp*Rh(eta1-NO3)(mu-pyz)(0.5)]2.CH2Cl2(3.CH2Cl2).	Methylene Chloride	120-126	DNA polymerase iota	Homo sapiens	17-21
15252617-1	2004	[Cp*Rh(eta1-NO3)(eta2-NO3)] (1) reacted with pyrazine (pyz) to give a dinuclear complex [Cp*Rh(eta1-NO3)(mu-pyz)(0.5)]2.CH2Cl2(3.CH2Cl2).	Methylene Chloride	120-126	secreted phosphoprotein 1	Homo sapiens	95-99
15252617-1	2004	[Cp*Rh(eta1-NO3)(eta2-NO3)] (1) reacted with pyrazine (pyz) to give a dinuclear complex [Cp*Rh(eta1-NO3)(mu-pyz)(0.5)]2.CH2Cl2(3.CH2Cl2).	Methylene Chloride	129-135	secreted phosphoprotein 1	Homo sapiens	7-11
15252617-1	2004	[Cp*Rh(eta1-NO3)(eta2-NO3)] (1) reacted with pyrazine (pyz) to give a dinuclear complex [Cp*Rh(eta1-NO3)(mu-pyz)(0.5)]2.CH2Cl2(3.CH2Cl2).	Methylene Chloride	129-135	DNA polymerase iota	Homo sapiens	17-21
15252617-1	2004	[Cp*Rh(eta1-NO3)(eta2-NO3)] (1) reacted with pyrazine (pyz) to give a dinuclear complex [Cp*Rh(eta1-NO3)(mu-pyz)(0.5)]2.CH2Cl2(3.CH2Cl2).	Methylene Chloride	129-135	secreted phosphoprotein 1	Homo sapiens	95-99
15080703-7	2004	Sequestration of a methylene chloride solution of the Ds-pip complex from aqueous media by a NO-permeable membrane allows for fluorescence detection of NO for potential applications in biological fluids.	Methylene Chloride	19-37	prolactin induced protein	Homo sapiens	57-60
15252534-1	2004	Cationic nitrile complexes and neutral halide and cyanide complexes, with the general formula [MnL1L2(NO)(eta-C5H4Me)]z, undergo one-electron oxidation at a Pt electrode in CH2Cl2.	Methylene Chloride	173-179	endothelin receptor type A	Homo sapiens	106-109
15251288-6	2004	The dimethoxylated PCB congeners were readily converted into the respective dihydroxylated PCB derivatives using boron tribromide in dichloromethane.	Methylene Chloride	133-148	pyruvate carboxylase	Homo sapiens	19-22
15251288-6	2004	The dimethoxylated PCB congeners were readily converted into the respective dihydroxylated PCB derivatives using boron tribromide in dichloromethane.	Methylene Chloride	133-148	pyruvate carboxylase	Homo sapiens	91-94
15172992-2	2004	The purpose of this investigation was to determine the commonality for inactivation of the DAP-kinase gene in adenocarcinomas induced in mice by chronic exposure to mainstream cigarette smoke, the tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and vinyl carbamate, and the occupational carcinogen methylene chloride.	Methylene Chloride	323-341	death associated protein kinase 1	Mus musculus	91-101
15172992-7	2004	In addition, DAP-kinase methylation was detected in 52%, 60%, and 50% of tumors associated with NNK, vinyl carbamate, and methylene chloride, respectively.	Methylene Chloride	122-140	death associated protein kinase 1	Mus musculus	13-23
14599181-2	2003	These complexes can be obtained either via a halide metathesis reaction with AgF in dichloromethane or by reacting the corresponding dimethyl complexes with XeF2.	Methylene Chloride	84-99	angiopoietin like 6	Homo sapiens	77-80
13129340-5	2003	Complex 3 showed reaction with PPh3 in THF/CH2Cl2 to yield complex 2 and Ph3PO.	Methylene Chloride	43-49	protein phosphatase 4 catalytic subunit	Homo sapiens	31-35
14512878-8	2003	Exogenous CO administration or treatment with the CO-releasing agent methylene chloride mimicked the protective effect of HO-1, whereas treatment with exogenous biliverdin or overexpression of ferritin by recombinant adenoviral gene transfer did not.	Methylene Chloride	69-87	heme oxygenase 1	Mus musculus	122-126
12818669-1	2003	A combined system of bismuth triflate [Bi(OTf)(3)] and boron trifluoride etherate (BF(3).OEt(2)) in dichloromethane is an efficient promoter for the glycosylation of N-acetylneuraminic acid derivatives.	Methylene Chloride	100-115	POU class 5 homeobox 1	Homo sapiens	39-48
12798173-2	2003	Hydroxylated metabolites catalyzed by human CYP1B1 were extracted with methylene chloride and derivatized with BSTFA-10% TMCS.	Methylene Chloride	71-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-50
12176246-3	2002	The 3,4-DAP was dispersed in dichloromethane, leading to a suspension.	Methylene Chloride	29-44	death associated protein	Homo sapiens	8-11
12510749-5	2002	CL intensities of CH2Cl2, CHCl3, and CCl4 at the same concentration increased in the order CH2Cl2 < CHCl3 < CCl4.	Methylene Chloride	18-24	C-C motif chemokine ligand 4	Homo sapiens	114-118
12510749-5	2002	CL intensities of CH2Cl2, CHCl3, and CCl4 at the same concentration increased in the order CH2Cl2 < CHCl3 < CCl4.	Methylene Chloride	91-97	C-C motif chemokine ligand 4	Homo sapiens	37-41
12510749-5	2002	CL intensities of CH2Cl2, CHCl3, and CCl4 at the same concentration increased in the order CH2Cl2 < CHCl3 < CCl4.	Methylene Chloride	91-97	C-C motif chemokine ligand 4	Homo sapiens	114-118
12458511-1	2002	Three CH2Cl2 molecules encapsulating a Pd2(mu-F)2 square and new implications for catalysis.	Methylene Chloride	6-12	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	39-42
12392433-4	2002	Moreover, XeF2 rapidly oxidizes 2,2,2-crypt in CH2Cl2 solvent at room temperature to form HF and HF2-.	Methylene Chloride	47-53	complement factor H	Homo sapiens	97-100
12371826-1	2002	Nitrosonium triflate reacts with cold methylene chloride solutions of mer,trans-ReH(CO)3(PPh3)2 (1) with 1,1-insertion of NO+ into the Re-H bond to give the orange nitroxyl complex [mer,trans-Re(NH=O)(CO)3(PPh3)2][SO3CF3] (3) in 86% isolated yield.	Methylene Chloride	38-56	caveolin 1	Homo sapiens	89-93
12371826-1	2002	Nitrosonium triflate reacts with cold methylene chloride solutions of mer,trans-ReH(CO)3(PPh3)2 (1) with 1,1-insertion of NO+ into the Re-H bond to give the orange nitroxyl complex [mer,trans-Re(NH=O)(CO)3(PPh3)2][SO3CF3] (3) in 86% isolated yield.	Methylene Chloride	38-56	carboxylesterase 1	Homo sapiens	135-139
12371826-1	2002	Nitrosonium triflate reacts with cold methylene chloride solutions of mer,trans-ReH(CO)3(PPh3)2 (1) with 1,1-insertion of NO+ into the Re-H bond to give the orange nitroxyl complex [mer,trans-Re(NH=O)(CO)3(PPh3)2][SO3CF3] (3) in 86% isolated yield.	Methylene Chloride	38-56	caveolin 1	Homo sapiens	206-210
12371826-5	2002	The nitroxyl complex [cis,trans-OsBr(NH=O)(CO)2(PPh3)2][SO3CF3] (8) can be similarly prepared as orange crystals in 52% yield by reaction of cis,trans-OsHBr(CO)2(PPh3)2 (7) with [NO][SO3CF3] in cold methylene chloride solution.	Methylene Chloride	199-217	caveolin 1	Homo sapiens	48-52
12945905-1	2003	The reaction of aryl alkynes with dilute methylene chloride solutions of quaternary ammonium bromide and 20% trifluoroacetic acid produces primarily the syn Markovnikov adducts of hydrogen bromide.	Methylene Chloride	41-59	synemin	Homo sapiens	153-156
12708844-4	2003	Detailed mechanistic studies disclose the facile epimerization of aromatic alcohol in dichloromethane in the presence of In(OTf)3.	Methylene Chloride	86-101	POU class 5 homeobox 1	Homo sapiens	124-129
12711442-5	2003	Slower evaporation rate of acetone than dichloromethane enhanced phase separation between PCL and PEG during film formation, and resulted in the pore size in films prepared from acetone larger than from dichloromethane.	Methylene Chloride	40-55	PHD finger protein 1	Homo sapiens	90-93
12659553-2	2003	The resulting N-Boc diaryl hydrazines were directly oxidized with NBS/pyridine in CH(2)Cl(2) at room temperature to the azobenzenes.	Methylene Chloride	82-92	nibrin	Homo sapiens	66-69
12819363-2	2003	A dichloromethane extract of the sample was separated on C18 reversed-phase column with acetonitrile-50 mM ammonium acetate (80:20, v/v) as the mobile phase and analyzed by LC/MS via atmospheric pressure ionization/electrospray ionization interface.	Methylene Chloride	2-17	Bardet-Biedl syndrome 9	Homo sapiens	57-60
12550786-6	2003	In the simulation studies for microencapsulation, pegylated IFN showed better stability when exposed to dichloromethane as compared to native IFN.	Methylene Chloride	104-119	interferon alpha 1	Homo sapiens	60-63
12133272-9	2002	To deliver CO, one of the downstream HO-1 mediators, allogeneic OLT recipients were exposed to methylene chloride.	Methylene Chloride	95-113	heme oxygenase 1	Rattus norvegicus	37-41
12127234-1	2002	A chromogenic bioassay was utilized to determine the antithrombin activity of the methylene chloride and methanol extracts prepared from forty-five plants of Russia.	Methylene Chloride	82-100	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	53-65
12141857-5	2002	Additionally, the known diterpene 16-hydroxyrosmanol (10) and a new aromatic diterpene 11 were obtained from 16-hydroxycarnosol (9) by reaction with Ph3P/NBS in CH2Cl2.	Methylene Chloride	161-167	nibrin	Homo sapiens	154-157
12044564-3	2002	When the crystalline insulin was dispersed in dichloromethane as solid-in-oil (S/O) dispersion, it was found that most of insulin molecules were inlaid on the surface of PLGA microcapsules.	Methylene Chloride	46-61	insulin	Homo sapiens	21-28
12044564-3	2002	When the crystalline insulin was dispersed in dichloromethane as solid-in-oil (S/O) dispersion, it was found that most of insulin molecules were inlaid on the surface of PLGA microcapsules.	Methylene Chloride	46-61	insulin	Homo sapiens	122-129
12044564-7	2002	This phenomenon can be theoretically presumed to occur because insulin and PLGA molecules, having amphiphilic properties, converge on the interface between the hydrophilic additive and dichloromethane.	Methylene Chloride	185-200	insulin	Homo sapiens	63-70
12005482-5	2002	Cleavage studies of Leu-enkephalin anchored to either o-BAL or p-BAL handles revealed that both handles were surprisingly acid-labile and released the peptide with dilute TFA (5% and even 1% TFA in CH2Cl2).	Methylene Chloride	198-204	prodynorphin	Homo sapiens	20-34
11933148-5	2002	Elastase (3.4.21.37) was inhibited by both aqueous and dichloromethane extracts of the Basidiomycetes, with the aqueous extracts active at concentrations of 200 microg/mL.	Methylene Chloride	55-70	elastase, neutrophil expressed	Homo sapiens	0-8
11869107-1	2002	[reaction: see text] The Sc(OTf)3/FERRODIOL (2) complex was prepared at -78 degrees C in CH2Cl2 in the presence of 2,6-lutidine and MS 4A.	Methylene Chloride	89-95	POU class 5 homeobox 1	Homo sapiens	25-33
11578736-2	2001	Powder formulations of BSA obtained by spray-freeze drying were first suspended in methylene chloride containing PLG followed by coacervation by adding silicon oil and microsphere hardening in heptane.	Methylene Chloride	83-101	plasminogen	Homo sapiens	113-116
11884241-4	2002	The carcinogenic effects of DCM in the mouse are caused by the interaction with DNA of a glutathione (GSH) conjugate that is produced by the class theta glutathione S-transferase T1-1 (GST T1-1).	Methylene Chloride	28-31	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	179-183
11884241-4	2002	The carcinogenic effects of DCM in the mouse are caused by the interaction with DNA of a glutathione (GSH) conjugate that is produced by the class theta glutathione S-transferase T1-1 (GST T1-1).	Methylene Chloride	28-31	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	189-193
11884241-7	2002	The results show that mouse GST T1-1 is more efficient in catalyzing the conjugation of DCM with GSH than the orthologous human enzyme.	Methylene Chloride	88-91	glutathione S-transferase, theta 1	Mus musculus	28-36
11843606-3	2002	Treatment of a dichloromethane solution of syn- and anti-1,3-diol-acetonide with a catalytic amount of diluted aqueous hydrochloric acid leads to the selective cleavage of the anti diastereomer.	Methylene Chloride	15-30	synemin	Homo sapiens	43-46
11854317-9	2002	Upon CdCl(2)-treatment, both Sertoli cells and the germ cells upregulated Fas ligand; this event was also suppressed by zinc protoporphyrin-IX and restored by dichloromethane.	Methylene Chloride	159-174	Fas ligand	Homo sapiens	74-84
11785697-5	2001	The conformation of insulin protected by a 10-fold molar excess of SDS recovered after 1 h of contact with MC was evaluated via circular dichroism (CD) spectroscopy.	Methylene Chloride	107-109	insulin	Homo sapiens	20-27
11785697-9	2001	CD spectra indicated that the presence of insulin in SDS after 1 h of contact with MC qualitatively retained its secondary structure integrity.	Methylene Chloride	83-85	insulin	Homo sapiens	42-49
11513428-2	2001	N-nitrosodimethylamine (NDMA) and N-nitrosopyrrolidine (NPYR) as well as N-nitrosohexamethyleneimine (NHMI) can be adsorbed on zeolite Y, ZSM-5 and A in the solution of methylene chloride or water, which will be helpful for removal of the N-nitrosamines pollution in environmental protection.	Methylene Chloride	169-187	neuropeptide Y receptor Y1	Homo sapiens	34-61
11578104-0	2001	Improved activity and stability of lysozyme at the water/CH2Cl2 interface: enzyme unfolding and aggregation and its prevention by polyols.	Methylene Chloride	57-63	lysozyme	Homo sapiens	35-43
11578104-3	2001	When lysozyme was exposed to a large water/CH2Cl2 interface achieved by homogenization, lysozyme aggregation occurred.	Methylene Chloride	43-49	lysozyme	Homo sapiens	5-13
11578104-3	2001	When lysozyme was exposed to a large water/CH2Cl2 interface achieved by homogenization, lysozyme aggregation occurred.	Methylene Chloride	43-49	lysozyme	Homo sapiens	88-96
11578104-6	2001	The observed loss in specific enzyme activity of soluble lysozyme was caused by the irreversible formation of an unfolded lysozyme species, which was found to be monomeric, and was able to leave the water/CH2Cl2 interface and accumulate in the aqueous phase.	Methylene Chloride	205-211	lysozyme	Homo sapiens	57-65
11578104-6	2001	The observed loss in specific enzyme activity of soluble lysozyme was caused by the irreversible formation of an unfolded lysozyme species, which was found to be monomeric, and was able to leave the water/CH2Cl2 interface and accumulate in the aqueous phase.	Methylene Chloride	205-211	lysozyme	Homo sapiens	122-130
11330911-3	2001	The reaction between the isomeric carborane arachno-4,5-C2B7H13 (4) and PCl3 in dichloromethane in the presence of PS gave the asymmetrical isomer, nido-7,8,9,10-P2C2B7H, (5).	Methylene Chloride	80-95	PHD finger protein 19	Homo sapiens	72-76
11569885-2	2001	MAE requires only 10 mL solvent and 10 min extraction time whereas Soxhlet uses 200 mL and takes 24 h. Although the yields were lower, dichloromethane (DCM) was preferred to pyridine, N-methyl-2-pyrrolidone (NMP), and NMP with CS2 because the pattern of the PACs is shown to be independent of solvent and DCM is a much more convenient solvent to work with.	Methylene Chloride	135-150	chorionic somatomammotropin hormone 2	Homo sapiens	227-230
11569885-2	2001	MAE requires only 10 mL solvent and 10 min extraction time whereas Soxhlet uses 200 mL and takes 24 h. Although the yields were lower, dichloromethane (DCM) was preferred to pyridine, N-methyl-2-pyrrolidone (NMP), and NMP with CS2 because the pattern of the PACs is shown to be independent of solvent and DCM is a much more convenient solvent to work with.	Methylene Chloride	152-155	chorionic somatomammotropin hormone 2	Homo sapiens	227-230
11446825-0	2001	A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane.	Methylene Chloride	91-106	glutathione S-transferase theta 1	Homo sapiens	40-45
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	23-38	glutathione S-transferase theta 1	Homo sapiens	92-123
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	23-38	glutathione S-transferase theta 1	Homo sapiens	125-130
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	40-43	glutathione S-transferase theta 1	Homo sapiens	92-123
11446825-1	2001	The carcinogenicity of dichloromethane (DCM) is related to metabolic activation mediated by glutathione transferase theta 1 (GSTT1), whereas oxidation serves as a detoxification pathway.	Methylene Chloride	40-43	glutathione S-transferase theta 1	Homo sapiens	125-130
11453994-0	2001	Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants.	Methylene Chloride	0-15	glutathione S-transferase theta 1	Rattus norvegicus	82-117
11453994-1	2001	Methylobacterium dichloromethanicum DM4 is able to grow with dichloromethane as the sole carbon and energy source by using a dichloromethane dehalogenase/glutathione S-transferase (GST) for the conversion of dichloromethane to formaldehyde.	Methylene Chloride	61-76	hematopoietic prostaglandin D synthase	Rattus norvegicus	154-179
11453994-1	2001	Methylobacterium dichloromethanicum DM4 is able to grow with dichloromethane as the sole carbon and energy source by using a dichloromethane dehalogenase/glutathione S-transferase (GST) for the conversion of dichloromethane to formaldehyde.	Methylene Chloride	125-140	hematopoietic prostaglandin D synthase	Rattus norvegicus	154-179
11453994-3	2001	However, the dehalogenation of dichloromethane by GST T1-1 from rat was highly mutagenic and toxic to methylotrophic bacteria.	Methylene Chloride	31-46	glutathione S-transferase theta 1	Rattus norvegicus	50-56
11453994-4	2001	Plasmid-driven expression of rat GST T1-1 in strain DM4-2cr, a mutant of strain DM4 lacking dichloromethane dehalogenase, reduced cell viability 10(5)-fold in the presence of dichloromethane.	Methylene Chloride	92-107	glutathione S-transferase theta 1	Rattus norvegicus	33-39
11453994-5	2001	This effect was exploited to select dichloromethane-resistant transconjugants of strain DM4-2cr carrying a plasmid-encoded rGSTT1 gene.	Methylene Chloride	36-51	glutathione S-transferase theta 1	Rattus norvegicus	123-129
11453994-8	2001	The enzymatic activity of purified His-tagged GST T1-1 variants expressed in Escherichia coli was markedly reduced with both dichloromethane and the alternative substrate 1,2-epoxy-3-(4"-nitrophenoxy)propane.	Methylene Chloride	125-140	glutathione S-transferase theta 1	Rattus norvegicus	46-52
11513067-8	2001	Dichloromethane (GM = 47 mg/m3, GSD = 2.62) was common in cleaning tasks.	Methylene Chloride	0-15	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	28-30
11488453-2	2001	Dichloromethane (DCM) extracts from dried leaves showed a marked cyclooxygenase (COX) inhibitory activity with a preferential effect on COX-2 catalysed prostaglandin synthesis.	Methylene Chloride	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11488453-2	2001	Dichloromethane (DCM) extracts from dried leaves showed a marked cyclooxygenase (COX) inhibitory activity with a preferential effect on COX-2 catalysed prostaglandin synthesis.	Methylene Chloride	17-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
11516501-9	2001	Pegylated lysozyme exhibited much better stability than native lysozyme against exposure to organic solvent (dichloromethane), homogenization, and showed reduced adsorption onto the surface of blank PLGA microspheres.	Methylene Chloride	109-124	lysozyme	Homo sapiens	10-18
11305924-1	2001	Xenon and dichloromethane are inhalational anesthetic agents whose binding to myoglobin has been demonstrated by X-ray crystallography.	Methylene Chloride	10-25	myoglobin	Homo sapiens	78-87
11305924-3	2001	Though specific binding of these anesthetics might be expected to stabilize myoglobin against unfolding, dichloromethane actually destabilized myoglobin at all examined concentrations of this anesthetic (15, 40, and 200 mM).	Methylene Chloride	105-120	myoglobin	Homo sapiens	143-152
11305924-5	2001	Thus, dichloromethane and xenon have opposite effects on myoglobin stability despite localization in comparably folded X-ray crystallographic structures.	Methylene Chloride	6-21	myoglobin	Homo sapiens	57-66
12541814-4	2001	were coated with 5 g/L solutions of PSI5 and PSI6 in dichloromethane by the static method, named column 15 and column 16.	Methylene Chloride	53-68	protocadherin gamma subfamily B, 9 pseudogene	Homo sapiens	45-49
11304153-5	2001	As a consequence, (TTF)3(BF4)2 oxidation of the radical anion does not afford the neutral Ni(F2pdt)2(0) but a TTF salt formulated as [TTF](3)[Ni(F2pdt)2]3[CH2Cl2].	Methylene Chloride	155-161	ras homolog family member H	Homo sapiens	19-22
11018744-9	2000	For example, mice exposed to dichloromethane show a dose-dependent incidence of cancer via the GSTT1-1 pathway.	Methylene Chloride	29-44	glutathione S-transferase, theta 1	Mus musculus	95-102
11158713-1	2001	Dichloromethane (methylene chloride, DCM) is metabolized via two pathways in humans: mixed-function oxidases (MFO) and glutathione-S:-transferase (GST).	Methylene Chloride	0-15	glutathione S-transferase kappa 1	Homo sapiens	119-145
11158713-1	2001	Dichloromethane (methylene chloride, DCM) is metabolized via two pathways in humans: mixed-function oxidases (MFO) and glutathione-S:-transferase (GST).	Methylene Chloride	0-15	glutathione S-transferase kappa 1	Homo sapiens	147-150
11158713-1	2001	Dichloromethane (methylene chloride, DCM) is metabolized via two pathways in humans: mixed-function oxidases (MFO) and glutathione-S:-transferase (GST).	Methylene Chloride	17-35	glutathione S-transferase kappa 1	Homo sapiens	119-145
11158713-1	2001	Dichloromethane (methylene chloride, DCM) is metabolized via two pathways in humans: mixed-function oxidases (MFO) and glutathione-S:-transferase (GST).	Methylene Chloride	17-35	glutathione S-transferase kappa 1	Homo sapiens	147-150
11322544-5	2001	Removal of the phenylfluorenyl group was achieved with up to 3% TFA in dichloromethane in the presence of triethylsilane at 0 degrees C. These protecting-group techniques were successfully applied in the synthesis of differently lipidated H-Ras peptides.	Methylene Chloride	71-86	HRas proto-oncogene, GTPase	Homo sapiens	239-244
11238968-1	2001	Dichloromethane dehalogenase/glutathione S-transferase allows methylotrophic bacteria to grow with dichloromethane (DCM), a predominantly man-made compound.	Methylene Chloride	0-15	glutathione S-transferase kappa 1	Homo sapiens	29-54
11238968-1	2001	Dichloromethane dehalogenase/glutathione S-transferase allows methylotrophic bacteria to grow with dichloromethane (DCM), a predominantly man-made compound.	Methylene Chloride	99-114	glutathione S-transferase kappa 1	Homo sapiens	29-54
11238968-1	2001	Dichloromethane dehalogenase/glutathione S-transferase allows methylotrophic bacteria to grow with dichloromethane (DCM), a predominantly man-made compound.	Methylene Chloride	116-119	glutathione S-transferase kappa 1	Homo sapiens	29-54
11166419-3	2001	Prior to encapsulation, IGF-I was exposed to ultrasonication in a water/dichloromethane dispersion, and its stability tested in the presence and absence of various excipients in the W(1) phase.	Methylene Chloride	72-87	insulin like growth factor 1	Homo sapiens	24-29
11064134-2	2000	FTIR-ATR (attenuated total reflectance) spectroscopy was used to monitor the polyanhydride/anhydride reaction rates in dichloromethane, dichloroethane, chloroform, and 1,4-dioxane solutions at room temperature.	Methylene Chloride	119-134	ATR serine/threonine kinase	Homo sapiens	5-8
10961399-5	2000	The soluble orange-red ferrocenyl dendrimers can also be oxidized in CH2Cl2 by [NO][PF6] to the insoluble deep blue polyferrocenium dendrimers.	Methylene Chloride	69-75	sperm associated antigen 17	Homo sapiens	84-87
11076074-2	2000	A dichloromethane extract of the sample was separated on C18 reversed-phase column with acetonitrile-50 mM ammonium acetate (80:20, v/v) as the mobile phase and analyzed by LC-MS via atmospheric pressure ionization/electrospray ionization interface.	Methylene Chloride	2-17	Bardet-Biedl syndrome 9	Homo sapiens	57-60
10956516-2	2000	Following conventional solid-phase peptide synthesis, an excess of Me(2)AlCl and EtSH in dichloromethane cleaves peptides from Wang or Pam resins to give the corresponding thioesters directly in good yield and purity.	Methylene Chloride	89-104	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	135-138
11196780-10	2000	The Cu(I) complexes [Cu(MeC(CH2ER)3)2]PF6 were obtained from [Cu(NCMe)4]PF6 and tripod ligand in CH2Cl2 solution.	Methylene Chloride	97-103	C-C motif chemokine ligand 28	Homo sapiens	24-27
11196780-10	2000	The Cu(I) complexes [Cu(MeC(CH2ER)3)2]PF6 were obtained from [Cu(NCMe)4]PF6 and tripod ligand in CH2Cl2 solution.	Methylene Chloride	97-103	sperm associated antigen 17	Homo sapiens	38-41
11428118-4	2000	Methylene chloride solutions of Fe(OTf)2 and Me3tacn afford crystals of [Fe(Me3tacn)(MeCN)2(OTf)](OTf) (3).	Methylene Chloride	0-18	POU class 2 homeobox 2	Homo sapiens	35-40
10773332-10	2000	In addition, it was demonstrated that the GM-CSF lowered the interfacial tension between the GM-CSF aqueous solution and the methylene chloride organic phase.	Methylene Chloride	125-143	colony stimulating factor 2	Homo sapiens	42-48
10773332-10	2000	In addition, it was demonstrated that the GM-CSF lowered the interfacial tension between the GM-CSF aqueous solution and the methylene chloride organic phase.	Methylene Chloride	125-143	colony stimulating factor 2	Homo sapiens	93-99
11196994-6	2000	Treatment of Pd(PPh3)4 with [W(CO)5[PPh2[CS2(CH2)nCN]]] (n = 1, 8a; n = 2, 8b) in CH2Cl2 affords syn-[(Ph3P)2Pd[mu-eta 1,eta 2-[CS2(CH2)nCN]PPh2]W(CO)5] (n = 1, 9a; n = 2, 9b).	Methylene Chloride	82-88	protein phosphatase 4 catalytic subunit	Homo sapiens	16-20
11196994-6	2000	Treatment of Pd(PPh3)4 with [W(CO)5[PPh2[CS2(CH2)nCN]]] (n = 1, 8a; n = 2, 8b) in CH2Cl2 affords syn-[(Ph3P)2Pd[mu-eta 1,eta 2-[CS2(CH2)nCN]PPh2]W(CO)5] (n = 1, 9a; n = 2, 9b).	Methylene Chloride	82-88	secreted phosphoprotein 1	Homo sapiens	115-120
11196994-6	2000	Treatment of Pd(PPh3)4 with [W(CO)5[PPh2[CS2(CH2)nCN]]] (n = 1, 8a; n = 2, 8b) in CH2Cl2 affords syn-[(Ph3P)2Pd[mu-eta 1,eta 2-[CS2(CH2)nCN]PPh2]W(CO)5] (n = 1, 9a; n = 2, 9b).	Methylene Chloride	82-88	DNA polymerase iota	Homo sapiens	121-126
12526521-4	2000	1(2+) reacts slowly with PF6- anions in acetone or KF in CH2Cl2 to yield the mu 3-fluorido complex 2(2+) with idealized D3 symmetry, containing a trigonal planar Cu3F core, as shown by single-crystal X-ray diffraction.	Methylene Chloride	57-63	sperm associated antigen 17	Homo sapiens	25-28
10789447-9	2000	The phenylsulfanyl group was finally removed with P(OEt)3/NEt3 in CH2Cl2 (three examples, 43-62% yield).	Methylene Chloride	66-72	tetraspanin 2	Homo sapiens	58-62
11203618-10	2000	CONCLUSION: It is recommended that dichloromethane be applied on the denture teeth ridge-lap area prior to denture base processing.	Methylene Chloride	35-50	LAP	Homo sapiens	89-92
12526466-4	2000	[Cs(tetrabenzo-24-crown-8)(eta 1-NCMe)2(eta 2-CH2Cl2)][NO3] (2): triclinic, P1, a = 12.295(3) A, b = 13.295(3) A, c = 13.782(3) A, alpha = 89.105(17) degrees, beta = 66.096(18) degrees, gamma = 71.980(19) degrees, V = 1929.5(8) A3, Z = 2.	Methylene Chloride	45-52	secreted phosphoprotein 1	Homo sapiens	27-32
12526550-1	2000	Protonation of the classical trihydride [(triphos)RhH3] (2) at 210 K in either THF or CH2Cl2 by either HBF4.OMe2 or CF3SO2OH gives the nonclassical eta 2-H2 complex [(triphos)Rh(eta 2-H2)H2]+ (1) [triphos = MeC(CH2PPh2)3].	Methylene Chloride	86-92	DNA polymerase iota	Homo sapiens	148-153
12526550-1	2000	Protonation of the classical trihydride [(triphos)RhH3] (2) at 210 K in either THF or CH2Cl2 by either HBF4.OMe2 or CF3SO2OH gives the nonclassical eta 2-H2 complex [(triphos)Rh(eta 2-H2)H2]+ (1) [triphos = MeC(CH2PPh2)3].	Methylene Chloride	86-92	DNA polymerase iota	Homo sapiens	178-183
12526550-4	2000	In CH2Cl2, 1 is stable up to 240 K. Above this temperature, the eta 2-H2 complex begins to convert into a mixture of trans- and cis-6, which, in turn, transform into the bridging-chloride dimers trans- and cis-[[(triphos)RhH]2(mu-Cl)2]2+ at room temperature.	Methylene Chloride	3-9	DNA polymerase iota	Homo sapiens	64-69
12526550-4	2000	In CH2Cl2, 1 is stable up to 240 K. Above this temperature, the eta 2-H2 complex begins to convert into a mixture of trans- and cis-6, which, in turn, transform into the bridging-chloride dimers trans- and cis-[[(triphos)RhH]2(mu-Cl)2]2+ at room temperature.	Methylene Chloride	3-9	suppressor of cytokine signaling 5	Homo sapiens	128-133
11203611-9	2000	CONCLUSION: It is recommended that dichloromethane be applied on the denture teeth ridge-lap area prior to denture base processing.	Methylene Chloride	35-50	LAP	Homo sapiens	89-92
11272542-3	2000	Comparison of the bimolecular reduction of [1]BF4 and 2 by triarylphosphines reveals a pronounced charge effect, with the cationic species being reduced by PPh3 about 1,000 times faster than its neutral analogue in CH2Cl2 at room temperature.	Methylene Chloride	215-221	caveolin 1	Homo sapiens	156-160
11931114-5	2000	Oxidation of [RuII(Por)-(NH2tBu)2] by bromine in dichloromethane in the presence of tert-butylamine and traces of water produced oxo(imido)ruthenium(VI) porphyrins, [RuVI-O(Por)(NtBu)] (Por=TPP, 3,4,5-MeO-TPP, TTP, 4-Cl-TPP, 3,5-Cl-TPP).	Methylene Chloride	49-64	cytochrome p450 oxidoreductase	Homo sapiens	19-22
11931114-5	2000	Oxidation of [RuII(Por)-(NH2tBu)2] by bromine in dichloromethane in the presence of tert-butylamine and traces of water produced oxo(imido)ruthenium(VI) porphyrins, [RuVI-O(Por)(NtBu)] (Por=TPP, 3,4,5-MeO-TPP, TTP, 4-Cl-TPP, 3,5-Cl-TPP).	Methylene Chloride	49-64	cytochrome p450 oxidoreductase	Homo sapiens	173-176
11931114-5	2000	Oxidation of [RuII(Por)-(NH2tBu)2] by bromine in dichloromethane in the presence of tert-butylamine and traces of water produced oxo(imido)ruthenium(VI) porphyrins, [RuVI-O(Por)(NtBu)] (Por=TPP, 3,4,5-MeO-TPP, TTP, 4-Cl-TPP, 3,5-Cl-TPP).	Methylene Chloride	49-64	cytochrome p450 oxidoreductase	Homo sapiens	173-176
10666016-2	2000	After fractionation, only the dichloromethane extract was active against the PLA2 in vitro test.	Methylene Chloride	30-45	phospholipase A2, group V	Mus musculus	77-81
10836034-2	1999	The acrylate esters of these alcohols undergo BCl3-catalyzed Diels-Alder reactions with a variety of dienes at -78 to -55 degrees C in CH2Cl2 or C7H8 with high dienophile face selectivity (Table 1).	Methylene Chloride	135-141	BCL3 transcription coactivator	Homo sapiens	46-50
9870262-1	1998	The effect of the C-3 substituent on the reaction of androst-5-enes with mercury(II) trifluoroacetate in dichloromethane (modified Treibs oxidation) was investigated.	Methylene Chloride	105-120	complement C3	Homo sapiens	18-21
10691188-7	1999	The correlation between the immunological assay and a functional one i.e. by the means of the assay of its anticoagulant activity (activated partial thromboplastin time) made it possible to show that protein C amino acids 166-169 of the activation peptide were probably altered after ultrasonication and methylene chloride treatment.	Methylene Chloride	304-322	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	200-209
10350186-6	1999	Moreover, the presence of DCM inhibited growth with methanol of the DM4-2cr transconjugant expressing the rat liver GSTT1-1.	Methylene Chloride	26-29	glutathione S-transferase theta 1	Rattus norvegicus	116-123
10350186-8	1999	Under the same conditions, however, GST-mediated conversion of DCM to formaldehyde was lower in cell-free extracts of the transconjugant expressing the rat GSTT1 than in the corresponding strain expressing the bacterial DCM dehalogenase.	Methylene Chloride	63-66	glutathione S-transferase theta 1	Rattus norvegicus	156-161
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Methylene Chloride	30-45	glutathione S-transferase theta 1	Homo sapiens	105-138
10438655-1	1999	The carcinogenic potential of dichloromethane (DCM) has been linked to its metabolism to formaldehyde by glutathione-S-transferase theta 1 (GSTT1).	Methylene Chloride	30-45	glutathione S-transferase theta 1	Homo sapiens	140-145
11674293-3	1999	Strongly chelating TiCl(4) led to the syn isomer in high diastereomeric excess in noncoordinating solvents (CH(2)Cl(2)) at -78 degrees C with BH(3).py as reducing agent, while nonchelating CeCl(3) gave a high excess of the anti isomer in coordinating solvents (THF) at the same temperature with lithium triethylborohydride (LiEt(3)BH) as reducing agent.	Methylene Chloride	108-119	synemin	Homo sapiens	38-41
9854036-7	1999	Recombinant mouse GSTT1-1 was catalytically active towards 1, 2-epoxy-3-(p-nitrophenoxy)propane, 4-nitrobenzyl chloride and dichloromethane.	Methylene Chloride	124-139	glutathione S-transferase, theta 1	Mus musculus	18-25
11672264-5	1998	Analogously, (2R,3R)-3-(cis-2,6-dimethylpiperidino)-3-phenyl-1,2-propanediol (11) has been anchored to a 2-chlorotrityl chloride resin (Barlos resin) in dichloromethane in the presence of diisopropylethylamine, and the anchoring process has been also monitored by (13)C gel-phase NMR spectroscopy.	Methylene Chloride	153-168	suppressor of cytokine signaling 2	Homo sapiens	24-29
9795050-2	1998	Lysozyme powder, which was prepared from lyophilization after adjusting a lysozyme solution pH at 3, was molecularly dissolved in a co-solvent system composed of dimethylsulfoxide (DMSO) and methylene chloride.	Methylene Chloride	191-209	lysozyme	Homo sapiens	0-8
9841810-1	1998	The ability of a methylene chloride extract of diesel exhaust particle (EDEP) to activate the aryl hydrocarbon receptor (AhR), bind to and activate the estrogen receptor (ER), and induce gene expression mediated via these nuclear receptors was examined in Hepa1c1c7 mouse hepatoma and MCF-7 human breast cancer cells.	Methylene Chloride	17-35	aryl-hydrocarbon receptor	Mus musculus	94-119
9841810-1	1998	The ability of a methylene chloride extract of diesel exhaust particle (EDEP) to activate the aryl hydrocarbon receptor (AhR), bind to and activate the estrogen receptor (ER), and induce gene expression mediated via these nuclear receptors was examined in Hepa1c1c7 mouse hepatoma and MCF-7 human breast cancer cells.	Methylene Chloride	17-35	aryl-hydrocarbon receptor	Mus musculus	121-124
9792420-13	1998	The reported location of GSTT1 is consistent with its known metabolic activity toward compounds such as dichloromethane and their metabolism into genotoxic products.	Methylene Chloride	104-119	glutathione S-transferase, theta 1	Mus musculus	25-30
11666733-8	1996	Crystal data for PtP(2)O(3)C(28)H(26).CH(2)Cl(2): P2(1)/c, Z = 4, T approximately 298 K, a = 11.744(2) A, b = 15.526(3) A, c = 15.866(3) A, beta = 101.58(1) degrees.	Methylene Chloride	38-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-57
9680411-2	1998	Glycosylation of the derived acceptor with reactive groups only at C-6 with an ortho ester of d-mannose proceeded smoothly in dichloromethane in the presence of trimethylsilyl trifluoromethanesulfonate, and the degree of branching was up to 0.6.	Methylene Chloride	126-141	complement C6	Homo sapiens	67-70
11670447-4	1998	The compound crystallizes as a solvate with two molecules of CH(2)Cl(2) per formula unit in the monoclinic space group P2(1)/n with a = 1570.5(2) pm, b = 1060.2(1) pm, c = 1604.0(2) pm, beta = 114.93(1) degrees, and Z = 2.	Methylene Chloride	61-71	cyclin dependent kinase inhibitor 1A	Homo sapiens	119-124
9653765-2	1998	It was found that interaction of proteins such as tetanus toxoid (TT), diphtheria toxoid (DT), ovine growth hormone (oGH), and human chorionic gonadotropin-based antifertility vaccine (beta-hCG-TT) with DCM during primary emulsification stages of particle formulation led to the precipitation of the proteins at the aqueous organic interface with concomitant reduction in their immunoreactivity.	Methylene Chloride	203-206	growth hormone 1	Homo sapiens	101-115
9653765-3	1998	On the other hand, the B subunit of E. coli enterotoxin (LTB) was found to be comparatively stable toward the denaturing action of DCM.	Methylene Chloride	131-134	lymphotoxin beta	Homo sapiens	23-61
9368031-2	1997	A number of cytochrome P450 (P450) 2E1 substrates are known to show kinetic deuterium isotope effects of approximately 5 on Km (DK = DKm/HKm), but not on kcat, in rat liver microsomes (e.g. N-nitrosodimethylamine, ethanol, and CH2Cl2).	Methylene Chloride	227-233	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	12-38
9348725-12	1997	GPT increased significantly at 1,000 mg/kg of CH2Cl2.	Methylene Chloride	46-52	glutamic--pyruvic transaminase	Rattus norvegicus	0-3
9307035-0	1997	Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse.	Methylene Chloride	94-109	CD2 molecule	Homo sapiens	58-62
9307035-8	1997	In addition, recombinant human GST T1-1 was found to conjugate glutathione with dichloromethane, a pulmonary and hepatic carcinogen in the mouse.	Methylene Chloride	80-95	CD2 molecule	Homo sapiens	35-39
9648658-2	1998	The method includes extraction of insulin from human and rat plasma into dichloromethane, followed by back-extraction into 0.05 N hydrochloric acid.	Methylene Chloride	73-88	insulin	Homo sapiens	34-41
9629471-4	1998	Deprotection of the t-Boc protecting group was achieved with trifluoroacetic acid (TFAA) in methylene chloride.	Methylene Chloride	92-110	BOC cell adhesion associated, oncogene regulated	Homo sapiens	22-25
9242590-1	1997	Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1 mice.	Methylene Chloride	14-29	hematopoietic prostaglandin D synthase	Mus musculus	65-90
9242590-1	1997	Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1 mice.	Methylene Chloride	14-29	hematopoietic prostaglandin D synthase	Mus musculus	92-95
9242590-1	1997	Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1 mice.	Methylene Chloride	31-34	hematopoietic prostaglandin D synthase	Mus musculus	65-90
9242590-1	1997	Metabolism of dichloromethane (DCM) to formaldehyde (HCHO) via a glutathione S-transferase (GST) pathway is thought to be required for its carcinogenic effects in B6C3F1 mice.	Methylene Chloride	31-34	hematopoietic prostaglandin D synthase	Mus musculus	92-95
11671527-4	1997	These molybdenum-based receptors are chromogenic and, in methylene chloride, the affinities of the assembled receptors for dicarboxylic acids ranging from C(4) to C(8) have been assessed by UV-visible titrations after determining the stoichiometry of the complex formation using Job"s method.	Methylene Chloride	57-75	complement C4A (Rodgers blood group)	Homo sapiens	155-159
11671527-4	1997	These molybdenum-based receptors are chromogenic and, in methylene chloride, the affinities of the assembled receptors for dicarboxylic acids ranging from C(4) to C(8) have been assessed by UV-visible titrations after determining the stoichiometry of the complex formation using Job"s method.	Methylene Chloride	57-75	homeobox C8	Homo sapiens	163-167
9435885-2	1997	Recent studies have demonstrated that the mutagenicity of dichloromethane (CH2Cl2) and bromodichloromethane (BrCHCl2) can be mediated by a theta-class glutathione S-transferase (GSTT1-1).	Methylene Chloride	58-73	hematopoietic prostaglandin D synthase	Rattus norvegicus	151-176
9435885-2	1997	Recent studies have demonstrated that the mutagenicity of dichloromethane (CH2Cl2) and bromodichloromethane (BrCHCl2) can be mediated by a theta-class glutathione S-transferase (GSTT1-1).	Methylene Chloride	58-73	glutathione S-transferase theta 1	Rattus norvegicus	178-185
9435885-2	1997	Recent studies have demonstrated that the mutagenicity of dichloromethane (CH2Cl2) and bromodichloromethane (BrCHCl2) can be mediated by a theta-class glutathione S-transferase (GSTT1-1).	Methylene Chloride	75-81	hematopoietic prostaglandin D synthase	Rattus norvegicus	151-176
9435885-2	1997	Recent studies have demonstrated that the mutagenicity of dichloromethane (CH2Cl2) and bromodichloromethane (BrCHCl2) can be mediated by a theta-class glutathione S-transferase (GSTT1-1).	Methylene Chloride	75-81	glutathione S-transferase theta 1	Rattus norvegicus	178-185
9138628-6	1997	In addition, a methylene chloride/DMSO extract of the control pellets promoted expression of a reporter gene controlled by the estrogen receptor and demonstrated competition with 17 beta-estradiol for binding to the human estrogen receptor.	Methylene Chloride	15-33	estrogen receptor 1	Homo sapiens	127-144
9138628-6	1997	In addition, a methylene chloride/DMSO extract of the control pellets promoted expression of a reporter gene controlled by the estrogen receptor and demonstrated competition with 17 beta-estradiol for binding to the human estrogen receptor.	Methylene Chloride	15-33	estrogen receptor 1	Homo sapiens	222-239
8918684-9	1996	Insulin-induced increments in cortisol/ creatinine ratios were nonsignificant when urine samples were assayed after dichloromethane extraction.	Methylene Chloride	116-131	insulin	Canis lupus familiaris	0-7
8889796-8	1996	blocked COHb elevation completely, suggesting that the metabolic conversion of DCM to CO is mediated by cytochrome P-450 2E1 (P4502E1).	Methylene Chloride	79-82	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	104-124
8761485-10	1996	The relative activities between species, and the cellular and sub-cellular distribution within the liver and lungs of each species, provides an explanation for the species-specificity of methylene chloride, a mouse-specific carcinogen activated by glutathione S-transferase GSTT1-1.	Methylene Chloride	187-205	glutathione S-transferase, theta 1	Mus musculus	274-279
8799324-1	1996	A high activity glutathione S-transferase T1-1 (GSTT1-1) towards dichloromethane was isolated from human liver cytosol and purified to homogenity in 18.5% yield with a purification factor of 4400-fold.	Methylene Chloride	65-80	glutathione S-transferase theta 1	Homo sapiens	48-55
8671744-0	1996	DNA sequence analysis of methylene chloride-induced HPRT mutations in Chinese hamster ovary cells: comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde.	Methylene Chloride	25-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	52-56
8671744-2	1996	MC-induced mutations in the HPRT gene of Chinese hamster ovary cells have been sequenced and compared with the mutations induced by 1, 2-dibromoethane (1,2-DEB), which is known to act through a glutathione conjugate, and formaldehyde.	Methylene Chloride	0-2	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	28-32
8600370-0	1996	Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay.	Methylene Chloride	61-79	hematopoietic prostaglandin D synthase	Mus musculus	12-37
8600370-0	1996	Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay.	Methylene Chloride	61-79	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	104-108
8600370-2	1996	We have previously shown (Graves et al., 1995) that glutathione S-transferase (GST)-mediated metabolism of MC by mouse liver cytosol (S100 fraction) causes DNA single-strand (ss) breaks in CHO cells.	Methylene Chloride	107-109	hematopoietic prostaglandin D synthase	Mus musculus	52-77
8600370-2	1996	We have previously shown (Graves et al., 1995) that glutathione S-transferase (GST)-mediated metabolism of MC by mouse liver cytosol (S100 fraction) causes DNA single-strand (ss) breaks in CHO cells.	Methylene Chloride	107-109	hematopoietic prostaglandin D synthase	Mus musculus	79-82
8600370-3	1996	In this study, MC GST metabolites were shown to cause mutations at the HPRT locus of CHO cells.	Methylene Chloride	15-17	hematopoietic prostaglandin D synthase	Mus musculus	18-21
8600370-3	1996	In this study, MC GST metabolites were shown to cause mutations at the HPRT locus of CHO cells.	Methylene Chloride	15-17	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	71-75
8600370-5	1996	The MC GST metabolite formaldehyde was mutagenic in independent experiments, although the number of mutants induced was lower than with the MC.	Methylene Chloride	4-6	hematopoietic prostaglandin D synthase	Mus musculus	7-10
8600370-5	1996	The MC GST metabolite formaldehyde was mutagenic in independent experiments, although the number of mutants induced was lower than with the MC.	Methylene Chloride	140-142	hematopoietic prostaglandin D synthase	Mus musculus	7-10
7482563-8	1995	The frequency and pattern of H-ras gene activation were similar in control and methylene chloride-induced liver neoplasms.	Methylene Chloride	79-97	Harvey rat sarcoma virus oncogene	Mus musculus	29-34
8625454-5	1996	Ethylene dibromide, 1-bromo-2-chloroethane, 1,2-dichloroethane, and methylene dichloride induced umuC gene expression more strongly in the NM5004 strain than the original strain.	Methylene Chloride	68-88	DNA polymerase V subunit UmuC	Salmonella enterica subsp. enterica serovar Typhimurium	97-101
21619230-10	1996	Good agreement was obtained between a 45-min SPME and methylene chloride extraction for the determination of PAH concentrations in creosote-contaminated water, demonstrating that SPME is a useful technique for the rapid determination of hydrocarbons in complex water matrices.	Methylene Chloride	54-72	phenylalanine hydroxylase	Homo sapiens	109-112
8831906-1	1996	A new polymorphic form of glutathione S-transferase (GST), metabolising monohalogenated methanes, ethylene oxide and dichloromethane, has been purified from human erythrocytes and characterized.	Methylene Chloride	117-132	glutathione S-transferase kappa 1	Homo sapiens	26-51
8831906-1	1996	A new polymorphic form of glutathione S-transferase (GST), metabolising monohalogenated methanes, ethylene oxide and dichloromethane, has been purified from human erythrocytes and characterized.	Methylene Chloride	117-132	glutathione S-transferase kappa 1	Homo sapiens	53-56
7788840-8	1995	A significant (P < 0.05) negative correlation (r = -0.65 at 5 microM, r = -0.56 at 2 microM) was obtained in the GSTT1 positive donors between DEB-induced individual SCE frequency and RBC GSTT1 activity, measured by formaldehyde formation from dichloromethane; the GSTT1 null individuals showed no GSTT1 activity.	Methylene Chloride	247-262	glutathione S-transferase theta 1	Homo sapiens	116-121
7717874-1	1995	Based on the metabolism of dichloromethane (DCM) to carbon monoxide (CO), a process mediated by cytochrome P-4502E1 (CYP2E1), cytochrome c oxidase activity was determined in different tissues of rats after DCM exposure.	Methylene Chloride	27-42	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	117-123
7717874-1	1995	Based on the metabolism of dichloromethane (DCM) to carbon monoxide (CO), a process mediated by cytochrome P-4502E1 (CYP2E1), cytochrome c oxidase activity was determined in different tissues of rats after DCM exposure.	Methylene Chloride	44-47	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	117-123
7717874-1	1995	Based on the metabolism of dichloromethane (DCM) to carbon monoxide (CO), a process mediated by cytochrome P-4502E1 (CYP2E1), cytochrome c oxidase activity was determined in different tissues of rats after DCM exposure.	Methylene Chloride	206-209	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	117-123
7717874-5	1995	COHb formation due to DCM, 6.2 mmol/kg p.o., was completely prevented after treatment of rats with the mechanism-based inhibitor of CYP2E1, diethyl-dithiocarbamate (DDTC), using an oral dose of 32 mumol/kg.	Methylene Chloride	22-25	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	132-138
7879864-4	1994	After a de-lipidation step, the relatively polar metabolites that were extractable with dichloromethane represented the main fraction of the metabolites, which accounts for almost 50% of the total radioactivity of the tissue, of which E2 beta was the major metabolite (19.7%) and E1 and E2 alpha represented only 7.7 and 3.2%, respectively.	Methylene Chloride	88-103	dihydrolipoamide branched chain transacylase E2	Bos taurus	235-242
8578818-9	1995	Furthermore, at low antigen concentrations, DL-PLG microsphere vaccines prepared with the solvent methylene chloride induced higher antibody responses than those prepared using ethyl acetate as the solvent.	Methylene Chloride	98-116	plasminogen	Homo sapiens	47-50
8079362-2	1994	Both cytochrome P-450 (CYP)- and glutathione S-transferase (GST)-dependent metabolism of MC are known to occur.	Methylene Chloride	89-91	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	5-21
7702765-1	1994	Methylene chloride extracts of particulates from liquefied petroleum gas (LPG) combustion appliance were studied by using Ames test, micronucleus test and inducibility of pulmonary and hepatic aryl hydrocarbon hydroxylase (AHH) and glutathione S-transferase (GST) in rats.	Methylene Chloride	0-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	193-221
7827263-4	1994	The compound crystallizes in the monoclinic space group P2(1) from methanol-dichloromethane solution.	Methylene Chloride	76-91	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-61
8079362-2	1994	Both cytochrome P-450 (CYP)- and glutathione S-transferase (GST)-dependent metabolism of MC are known to occur.	Methylene Chloride	89-91	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	23-26
8079362-2	1994	Both cytochrome P-450 (CYP)- and glutathione S-transferase (GST)-dependent metabolism of MC are known to occur.	Methylene Chloride	89-91	hematopoietic prostaglandin D synthase	Mus musculus	33-58
8079362-2	1994	Both cytochrome P-450 (CYP)- and glutathione S-transferase (GST)-dependent metabolism of MC are known to occur.	Methylene Chloride	89-91	hematopoietic prostaglandin D synthase	Mus musculus	60-63
8079362-4	1994	Vacuolated bronchiolar cells were seen in mice exposed to 2000 and 4000 ppm MC but were not seen at lower concentrations, while addition of the CYP inhibitor, piperonyl butoxide, significantly reduced the bronchiolar cell vacuolation seen following exposure to 2000 ppm MC.	Methylene Chloride	76-78	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	144-147
8079362-4	1994	Vacuolated bronchiolar cells were seen in mice exposed to 2000 and 4000 ppm MC but were not seen at lower concentrations, while addition of the CYP inhibitor, piperonyl butoxide, significantly reduced the bronchiolar cell vacuolation seen following exposure to 2000 ppm MC.	Methylene Chloride	270-272	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	144-147
8079362-7	1994	The results suggest that the Clara cell vacuolation following MC exposure is mediated via CYP metabolism, that depression of the CYP metabolic pathway occurs following exposure, and that Clara cell vacuolation may have a priming role in stimulating cell proliferation in the unaffected cell population.	Methylene Chloride	62-64	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	90-93
7948589-1	1994	Poly(oxyethylene)-poly(oxypropylene) (PEO-PPO) co-polymers have been used as surfactants to produce resorbable poly(DL-lactide co-glycolide) (PLG) microspheres in the 500 nm-1 micron size range by an emulsification/solvent evaporation technique based on acetone-dichloromethane mixtures.	Methylene Chloride	262-277	protoporphyrinogen oxidase	Homo sapiens	42-45
8067899-4	1994	It is concluded that (i) cytochrome P-450 2E1 is involved in the metabolic conversion of both dichloromethane and salicylic acid, and (ii) salicylic acid may be an inducer of cytochrome P-450 2E1.	Methylene Chloride	94-109	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	25-45
8198545-6	1994	The GSTT1+ phenotype can catalyse the glutathione conjugation of dichloromethane, a metabolic pathway which has been shown to be mutagenic in Salmonella typhimurium mutagenicity tester strains and is believed to be responsible for carcinogenicity of dichloromethane in the mouse.	Methylene Chloride	65-80	glutathione S-transferase theta 1	Homo sapiens	4-9
8198545-6	1994	The GSTT1+ phenotype can catalyse the glutathione conjugation of dichloromethane, a metabolic pathway which has been shown to be mutagenic in Salmonella typhimurium mutagenicity tester strains and is believed to be responsible for carcinogenicity of dichloromethane in the mouse.	Methylene Chloride	250-265	glutathione S-transferase theta 1	Homo sapiens	4-9
7979958-0	1994	Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: influence of polymorphism of glutathione transferase theta (GST T1-1).	Methylene Chloride	14-29	glutathione S-transferase kappa 1	Homo sapiens	150-153
8067899-4	1994	It is concluded that (i) cytochrome P-450 2E1 is involved in the metabolic conversion of both dichloromethane and salicylic acid, and (ii) salicylic acid may be an inducer of cytochrome P-450 2E1.	Methylene Chloride	94-109	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	175-195
7979958-3	1994	The formation of formaldehyde from dichloromethane is influenced by the polymorphism of glutathione-S-transferase (GST) Theta, in the same way as the metabolism of methyl bromide, methyl chloride, methyl iodide and ethylene oxide.	Methylene Chloride	35-50	glutathione S-transferase kappa 1	Homo sapiens	88-113
7979958-3	1994	The formation of formaldehyde from dichloromethane is influenced by the polymorphism of glutathione-S-transferase (GST) Theta, in the same way as the metabolism of methyl bromide, methyl chloride, methyl iodide and ethylene oxide.	Methylene Chloride	35-50	glutathione S-transferase kappa 1	Homo sapiens	115-118
8239117-2	1993	We report seven cases, involving four patients, of intentional inhalation of CARB-MEDIC carburetor cleaner containing toluene (43.8%), methanol (23.2%), methylene chloride (20.5%), and propane (12.5%).	Methylene Chloride	153-171	syntaxin 8	Homo sapiens	77-81
7979958-5	1994	The metabolism of dichloromethane in hemolysate in vitro can be described by Michaelis-Menten kinetics; for an individual with high GST T1-1 enzyme activity, the maximum velocity of formaldehyde production was calculated to be approximately 180 pmol/min per mg Hb, the kM being approximately 60 mM dichloromethane.	Methylene Chloride	18-33	glutathione S-transferase kappa 1	Homo sapiens	132-135
7979958-5	1994	The metabolism of dichloromethane in hemolysate in vitro can be described by Michaelis-Menten kinetics; for an individual with high GST T1-1 enzyme activity, the maximum velocity of formaldehyde production was calculated to be approximately 180 pmol/min per mg Hb, the kM being approximately 60 mM dichloromethane.	Methylene Chloride	298-313	glutathione S-transferase kappa 1	Homo sapiens	132-135
7979958-6	1994	Carcinogenicity of dichloromethane in long-term inhalation exposure of rodents has been attributed to metabolism of the compound via the GST-dependent pathway.	Methylene Chloride	19-34	glutathione S-transferase kappa 1	Homo sapiens	137-140
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	88-106	glutathione S-transferase kappa 1	Homo sapiens	243-268
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	88-106	glutathione S-transferase kappa 1	Homo sapiens	270-273
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	108-123	glutathione S-transferase kappa 1	Homo sapiens	243-268
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	108-123	glutathione S-transferase kappa 1	Homo sapiens	270-273
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	125-128	glutathione S-transferase kappa 1	Homo sapiens	243-268
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	191-194	glutathione S-transferase kappa 1	Homo sapiens	243-268
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	191-194	glutathione S-transferase kappa 1	Homo sapiens	270-273
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	191-194	glutathione S-transferase kappa 1	Homo sapiens	243-268
8125209-3	1994	have developed physiologically based pharmacokinetic models for the human metabolism of methylene chloride (dichloromethane; DCM) and have advanced the hypothesis that the carcinogenicity of DCM is related to target organ metabolism of DCM by glutathione S-transferase (GST).	Methylene Chloride	191-194	glutathione S-transferase kappa 1	Homo sapiens	270-273
1446973-2	1992	The protected peptides were assembled using the mixed anhydride coupling methods with 40% TFA/CH2Cl2 used for removal of the Boc group from intermediate Boc-protected peptides.	Methylene Chloride	94-100	BOC cell adhesion associated, oncogene regulated	Homo sapiens	125-128
8241818-4	1993	When GC2 grade methylene chloride from Burdick & Jackson Laboratories was used, ETU recoveries ranged from 92 to 110%.	Methylene Chloride	15-33	solute carrier family 25 member 18	Homo sapiens	5-8
8512599-0	1993	Interindividual differences in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase in 22 human liver samples.	Methylene Chloride	59-77	glutathione S-transferase kappa 1	Homo sapiens	108-133
8512599-1	1993	The interindividual variation in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase (GST) was investigated with 22 human liver samples.	Methylene Chloride	61-79	glutathione S-transferase kappa 1	Homo sapiens	110-135
8512599-1	1993	The interindividual variation in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase (GST) was investigated with 22 human liver samples.	Methylene Chloride	61-79	glutathione S-transferase kappa 1	Homo sapiens	137-140
8388466-2	1993	In the presence of DCC and DMAP Cbz-beta-alanine reacts with ryanodine in CH2Cl2 to give O10eq-Cbz-beta-alanylryanodine (3a), which on hydrogenolysis yields the beta-alanyl ester (4a).	Methylene Chloride	74-80	DCC netrin 1 receptor	Homo sapiens	19-22
8504470-2	1993	To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli.	Methylene Chloride	70-88	Dcm	Escherichia coli	90-93
8504470-2	1993	To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli.	Methylene Chloride	70-88	Dcm	Escherichia coli	175-178
8504471-6	1993	This mutation profile was similar to that identified for the H-ras gene in the spontaneous liver tumors and suggests that methylene chloride acts in liver by promoting cells with spontaneous lesions.	Methylene Chloride	122-140	Harvey rat sarcoma virus oncogene	Mus musculus	61-66
8504471-8	1993	Except for activated K-ras genes detected in DNA from two methylene chloride induced tumors and one spontaneous tumor, no other transforming genes were identified.	Methylene Chloride	58-76	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	21-26
8504471-10	1993	The low number of spontaneous tumors available in this study limits the interpretation of the data, and thus the frequency and spectrum of K-ras activation in the methylene chloride induced tumors was not significantly different from that in the seven spontaneous tumors analyzed.	Methylene Chloride	163-181	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	139-144
8504472-0	1993	Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice.	Methylene Chloride	37-55	transformation related protein 53, pseudogene	Mus musculus	20-23
8504472-11	1993	Inactivation of p53 and possibly the retinoblastoma tumor suppressor gene appear to be infrequent events in lung and liver tumors from methylene chloride treated mice.	Methylene Chloride	135-153	transformation related protein 53, pseudogene	Mus musculus	16-19
8100433-9	1993	It is concluded that cytochrome P450 IIE1 (CYP 2E1) is responsible for the metabolic interaction of both DCM and MET, and MET may be an inducer of CYP 2E1.	Methylene Chloride	105-108	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	43-50
8100433-9	1993	It is concluded that cytochrome P450 IIE1 (CYP 2E1) is responsible for the metabolic interaction of both DCM and MET, and MET may be an inducer of CYP 2E1.	Methylene Chloride	105-108	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	147-154
8100433-10	1993	The two pathways of DCM, the oxidative via CYP 2E1 and the metabolism via GSH/GSH-S-transferase seem to be independent.	Methylene Chloride	20-23	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	43-50
1441760-2	1992	Aflatoxins B1, B2, G1, and G2, are extracted by methanol/water (85 + 15) and partitioned into methylene dichloride.	Methylene Chloride	94-114	anthocyanin regulatory R-S protein-like	Zea mays	11-29
1446973-2	1992	The protected peptides were assembled using the mixed anhydride coupling methods with 40% TFA/CH2Cl2 used for removal of the Boc group from intermediate Boc-protected peptides.	Methylene Chloride	94-100	BOC cell adhesion associated, oncogene regulated	Homo sapiens	153-156
24415192-3	1991	The monomer showed an ABS peak and a CD trough at 664 nm in CH2Cl2 (ABS peak at 665 nm in CCl4).	Methylene Chloride	60-66	C-C motif chemokine ligand 4	Homo sapiens	90-94
34812814-1	2021	The neutral complexes trans-(GeF4(PiPr3)2) and (GeF4(kappa2-L)) (L = CH3C(CH2PPh2)3 or P(CH2CH2PPh2)3) are obtained from (GeF4(MeCN)2) and the ligand in CH2Cl2.	Methylene Chloride	153-159	Rho guanine nucleotide exchange factor 4	Homo sapiens	29-33
2001359-1	1991	In an earlier publication, we reported that corrinoids catalyze the sequential reduction of CCl4 to CHCl3, CH2Cl2, CH3Cl, and CH4 with titanium(III) citrate as electron donor [Krone, U. E., Thauer, R. K., & Hogenkamp, H. P. C. (1989) Biochemistry 28, 4908-4914].	Methylene Chloride	107-113	C-C motif chemokine ligand 4	Homo sapiens	92-96
1848757-4	1991	Only GST 5-5 retains full activity during purification, and its activities towards the substrates 1,2-epoxy-3-(p-nitrophenoxy)propane, p-nitrobenzyl chloride, p-nitrophenethyl bromide, cumene hydroperoxide, dichloromethane and DNA hydroperoxide are 185, 86, 67, 42, 11 and 0.03 mumol/min per mg of protein respectively.	Methylene Chloride	207-222	glutathione S-transferase mu 3	Homo sapiens	5-12
34935054-9	2022	A mitochondrial membrane potential assay demonstrated that more cells became depolarized and the extent of cytochrome c release was markedly increased in a dose-dependent manner in HT-29 cells treated with DCM.	Methylene Chloride	206-209	cytochrome c, somatic	Homo sapiens	107-119
2279144-7	1990	The dichloromethane eluate from Bond Elut C18 was injected into the HPLC system.	Methylene Chloride	4-19	Bardet-Biedl syndrome 9	Homo sapiens	42-45
34812814-1	2021	The neutral complexes trans-(GeF4(PiPr3)2) and (GeF4(kappa2-L)) (L = CH3C(CH2PPh2)3 or P(CH2CH2PPh2)3) are obtained from (GeF4(MeCN)2) and the ligand in CH2Cl2.	Methylene Chloride	153-159	Rho guanine nucleotide exchange factor 4	Homo sapiens	48-52
34812814-1	2021	The neutral complexes trans-(GeF4(PiPr3)2) and (GeF4(kappa2-L)) (L = CH3C(CH2PPh2)3 or P(CH2CH2PPh2)3) are obtained from (GeF4(MeCN)2) and the ligand in CH2Cl2.	Methylene Chloride	153-159	Rho guanine nucleotide exchange factor 4	Homo sapiens	122-126
34431674-6	2021	It is found that o-PDI2 supports SB-CS yielding PDI +-PDI -, which is in equilibrium with the o-PDI2 first excited state in a polar solvent (CH2Cl2) while m-PDI2 and p-PDI2 exhibit accelerated internal conversion due to the motion of the linker along with subnanosecond intersystem crossing (ISC).	Methylene Chloride	141-147	peptidyl arginine deiminase 2	Homo sapiens	19-23
34182646-10	2021	The minimum inhibitory concentration assessed for dichloromethane extracts were 0.5 mg mL-1 for Staphylococcus hyicus and Enterococcus faecalis and 0.2 mg mL-1 for Streptococcus suis.	Methylene Chloride	50-65	L1 cell adhesion molecule	Mus musculus	87-91
34182646-10	2021	The minimum inhibitory concentration assessed for dichloromethane extracts were 0.5 mg mL-1 for Staphylococcus hyicus and Enterococcus faecalis and 0.2 mg mL-1 for Streptococcus suis.	Methylene Chloride	50-65	L1 cell adhesion molecule	Mus musculus	155-159
34771233-4	2021	In contrast, when the reaction was conducted in dichloromethane, chain-end thiol (PNVCL)6 star polymers could be obtained.	Methylene Chloride	48-63	steroidogenic acute regulatory protein	Homo sapiens	90-94
34869207-2	2021	The recognition behaviors of 1 in dichloromethane/acetonitrile solution to alkali metal ions (Na+ and K+), alkaline earth metal ions (Mg2+ and Ca2+), and transition metal ions (Co2+, Ni2+, Zn2+, Cd2+, Cu2+, Mn2+, and Ag+) have been investigated by UV-Vis and fluorescence spectra.	Methylene Chloride	34-49	CD2 molecule	Homo sapiens	195-198
34431674-6	2021	It is found that o-PDI2 supports SB-CS yielding PDI +-PDI -, which is in equilibrium with the o-PDI2 first excited state in a polar solvent (CH2Cl2) while m-PDI2 and p-PDI2 exhibit accelerated internal conversion due to the motion of the linker along with subnanosecond intersystem crossing (ISC).	Methylene Chloride	141-147	peptidyl arginine deiminase 1	Homo sapiens	48-51
34431674-6	2021	It is found that o-PDI2 supports SB-CS yielding PDI +-PDI -, which is in equilibrium with the o-PDI2 first excited state in a polar solvent (CH2Cl2) while m-PDI2 and p-PDI2 exhibit accelerated internal conversion due to the motion of the linker along with subnanosecond intersystem crossing (ISC).	Methylene Chloride	141-147	peptidyl arginine deiminase 1	Homo sapiens	54-57
34431674-6	2021	It is found that o-PDI2 supports SB-CS yielding PDI +-PDI -, which is in equilibrium with the o-PDI2 first excited state in a polar solvent (CH2Cl2) while m-PDI2 and p-PDI2 exhibit accelerated internal conversion due to the motion of the linker along with subnanosecond intersystem crossing (ISC).	Methylene Chloride	141-147	peptidyl arginine deiminase 2	Homo sapiens	96-100
34603672-1	2021	Treatment of hexachloropropene (Cl2C(double bond, length as m-dash)C(Cl)-CCl3) with Si2Cl6 and (nBu4N)Cl (1 : 4 : 1) in CH2Cl2 results in a quantitative conversion to the trisilylated, dichlorinated allyl anion salt (nBu4N)(Cl2C(double bond, length as m-dash)C(SiCl3)-C(SiCl3)2) ((nBu4N)(1)).	Methylene Chloride	120-126	C-C motif chemokine ligand 3	Homo sapiens	73-77
34280354-5	2021	In addition, the expression of various genes involved in carcinogenesis, namely, NFE2L2 (antioxidative response), CXCL8 (inflammation), CDH1 (cell adhesion), MMP9 (tissue remodeling) and MKI67 (cell proliferation) were altered in cholangiocytes treated with DCM.	Methylene Chloride	258-261	NFE2 like bZIP transcription factor 2	Homo sapiens	81-87
34280354-5	2021	In addition, the expression of various genes involved in carcinogenesis, namely, NFE2L2 (antioxidative response), CXCL8 (inflammation), CDH1 (cell adhesion), MMP9 (tissue remodeling) and MKI67 (cell proliferation) were altered in cholangiocytes treated with DCM.	Methylene Chloride	258-261	C-X-C motif chemokine ligand 8	Homo sapiens	114-119
34280354-5	2021	In addition, the expression of various genes involved in carcinogenesis, namely, NFE2L2 (antioxidative response), CXCL8 (inflammation), CDH1 (cell adhesion), MMP9 (tissue remodeling) and MKI67 (cell proliferation) were altered in cholangiocytes treated with DCM.	Methylene Chloride	258-261	cadherin 1	Homo sapiens	136-140
34280354-5	2021	In addition, the expression of various genes involved in carcinogenesis, namely, NFE2L2 (antioxidative response), CXCL8 (inflammation), CDH1 (cell adhesion), MMP9 (tissue remodeling) and MKI67 (cell proliferation) were altered in cholangiocytes treated with DCM.	Methylene Chloride	258-261	matrix metallopeptidase 9	Homo sapiens	158-162
34280354-5	2021	In addition, the expression of various genes involved in carcinogenesis, namely, NFE2L2 (antioxidative response), CXCL8 (inflammation), CDH1 (cell adhesion), MMP9 (tissue remodeling) and MKI67 (cell proliferation) were altered in cholangiocytes treated with DCM.	Methylene Chloride	258-261	marker of proliferation Ki-67	Homo sapiens	187-192
34280354-7	2021	In malignant cell lines (HuCCA-1 and RMCCA-1), DCM treatment resulted in increased CXCL8 and MMP9 transcription and decreased CDH1 transcription accompanied by increased invasion and migration capabilities of these cells.	Methylene Chloride	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
34280354-7	2021	In malignant cell lines (HuCCA-1 and RMCCA-1), DCM treatment resulted in increased CXCL8 and MMP9 transcription and decreased CDH1 transcription accompanied by increased invasion and migration capabilities of these cells.	Methylene Chloride	47-50	matrix metallopeptidase 9	Homo sapiens	93-97
34280354-7	2021	In malignant cell lines (HuCCA-1 and RMCCA-1), DCM treatment resulted in increased CXCL8 and MMP9 transcription and decreased CDH1 transcription accompanied by increased invasion and migration capabilities of these cells.	Methylene Chloride	47-50	cadherin 1	Homo sapiens	126-130
34754259-0	2021	Falcarindiol and dichloromethane fraction are bioactive components in Oplopanax elatus: Colorectal cancer chemoprevention via induction of apoptosis and G2/M cell cycle arrest mediated by cyclin A upregulation.	Methylene Chloride	17-32	cyclin A2	Homo sapiens	188-196
34322773-5	2021	Dichloromethane extract of site I soil sample caused maximum damage to 40 muL mL-1 DNA repair defective mutants and showed 38 and 49% survival in lexA and recA mutants, respectively, which was least among all the sites.	Methylene Chloride	0-15	L1 cell adhesion molecule	Mus musculus	78-82
34086162-0	2021	Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions.	Methylene Chloride	0-15	BCL2 associated X, apoptosis regulator	Homo sapiens	163-166
34086162-0	2021	Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions.	Methylene Chloride	0-15	tumor protein p53	Homo sapiens	168-171
34086162-0	2021	Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions.	Methylene Chloride	0-15	caspase 8	Homo sapiens	176-185
34124970-7	2021	Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 mug mL-1.	Methylene Chloride	0-15	L1 cell adhesion molecule	Mus musculus	129-133
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Methylene Chloride	14-20	interleukin 6	Mus musculus	112-125
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Methylene Chloride	14-20	tumor necrosis factor	Mus musculus	131-158
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Methylene Chloride	14-20	nitric oxide synthase 2, inducible	Mus musculus	215-236
34071911-7	2021	The 70% EtOH, CH2Cl2-soluble fraction, and water-soluble fraction inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-alpha, as well as markedly blocking LPS-induced expression of inducible NO synthase and cyclooxygenase-2 via inactivation of the nuclear factor-kappa B pathway.	Methylene Chloride	14-20	prostaglandin-endoperoxide synthase 2	Mus musculus	241-257
34071911-8	2021	In addition, the CH2Cl2-soluble fraction showed the most remarkable heme oxygenase (HO)-1 expression effects and increased nuclear erythroid 2-related factor translocation in the nucleus.	Methylene Chloride	17-23	heme oxygenase 1	Mus musculus	68-89
34071911-9	2021	In HT22 cells, the CH2Cl2-soluble fraction inhibited cell damage and ROS production caused by glutamate via the regulation of HO-1.	Methylene Chloride	19-25	heme oxygenase 1	Mus musculus	126-130
34071911-10	2021	Therefore, CH2Cl2-soluble fractions of S. horneri can attenuate oxidative action and neuroinflammatory responses via HO-1 induction, demonstrating their potential in the treatment of neuroinflammatory diseases.	Methylene Chloride	11-17	heme oxygenase 1	Mus musculus	117-121
34754259-9	2021	Under the same treatment condition, dichloromethane fraction caused cell cycle arrest at the G2/M phase by 32.6% (p < 0.01% vs. control of 23.4%), supported by upregulation of key cell cycle regulator cyclin A to 21.6% (p < 0.01% vs. control of 8.6%).	Methylene Chloride	36-51	cyclin A2	Homo sapiens	201-209
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Methylene Chloride	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
34070061-6	2021	The generation of the radical anion form of the dpp-BIAN ligand upon reduction of 1 in a CH2Cl2 solution was monitored by EPR spectroscopy.	Methylene Chloride	89-95	dentin sialophosphoprotein	Homo sapiens	48-51
35481086-4	2022	The results showed that the dichloromethane and ethyl acetate fractions showed the highest antioxidant activities, with 84.78 and 86.96% DPPH scavenging at 0.10 mug mL-1.	Methylene Chloride	28-43	L1 cell adhesion molecule	Mus musculus	165-169
34275786-1	2021	This study was carried out to isolate the secondary metabolites and to evaluate the antibacterial, antifungal, antioxidant, phytotoxic, anti-leishmanial and alpha-glucosidase activities of dichloromethane and methanol extracts of whole plant of Astragalus creticus.	Methylene Chloride	189-204	AT695_RS09985	Staphylococcus aureus	157-174
34275786-5	2021	The methanol extract exhibited better activity against Staphylococcus aureus (58.75%) while dichloromethane extract was found to be very active against Bacillus subtilis (56.30%).The methanol extract demonstrated highly significant phytotoxic (92.68% at 1000mug/ml) and antioxidant (64.55+-0.43%) potential while both extracts identified best inhibition of alpha-glucosidase enzyme.	Methylene Chloride	92-107	AT695_RS09985	Staphylococcus aureus	357-374
35631777-6	2022	Both extracts showed the capacity to inhibit alpha-glucosidase, especially the dichloromethane (EC50 = 0.52 mg/mL).	Methylene Chloride	79-94	sucrase-isomaltase	Homo sapiens	45-62
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Methylene Chloride	138-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
34908079-1	2022	In this study we self-assembled the four-armed porphyrin hetero dimer capsule Cap4, stabilized through amidinium-carboxylate salt bridges, in CH2Cl2 and CHCl3.	Methylene Chloride	142-148	caspase 8	Homo sapiens	78-82
34995071-9	2022	By analogy, the CH3Cl enters another hydrogen abstraction by Cl, producing HCl and the CH2Cl radical, which again undergoes a halogenation step with CCl4, generating CH2Cl2.	Methylene Chloride	166-172	C-C motif chemokine ligand 4	Homo sapiens	149-153
2559772-10	1989	The kinetics of CHCl3 and CH2Cl2 formation from CCl4 were similar to those with coenzyme F430 or aquocobalamin as catalysts and titanium(III) citrate as the reductant.	Methylene Chloride	26-32	C-C motif chemokine ligand 4	Homo sapiens	48-52
3341052-0	1988	Metabolism of dichloromethane and the subsequent binding of its product, carbon monoxide, to cytochrome P-450 in perfused rat liver.	Methylene Chloride	14-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109
2924819-4	1989	Moreover, proteinase-K treatment of lens protein before extraction with methylene chloride significantly increased the recoveries of Trp-P-1 and Trp-P-2.	Methylene Chloride	72-90	polycystin 1, transient receptor potential channel interacting	Homo sapiens	133-140
2924819-4	1989	Moreover, proteinase-K treatment of lens protein before extraction with methylene chloride significantly increased the recoveries of Trp-P-1 and Trp-P-2.	Methylene Chloride	72-90	polycystin 2, transient receptor potential cation channel	Homo sapiens	145-152
2498896-1	1989	The solution conformations of chromomycin A3 (CRA) and dechromose-A chromomycin A3 (CRA-B) in dichloromethane and methanol were studied by two-dimensional (2D) NMR techniques.	Methylene Chloride	94-109	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	84-87
2922756-12	1989	that metabolism of CH2Cl2 occurs in vivo by two competing pathways: a high-affinity saturable pathway (identified as MFO) and a low-affinity first-order pathway (identified as GST).	Methylene Chloride	19-25	glutathione S-transferase kappa 1	Homo sapiens	176-179
2549914-0	1989	Influence of cytochrome P-450 inhibitors on the inhalative uptake of methyl chloride and methylene chloride in male B6C3F1 mice.	Methylene Chloride	89-107	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	13-29
3436702-2	1987	It was found that the Moz-group can be removed rapidly and completely with 5-10% TFA in CH2Cl2.	Methylene Chloride	88-94	lysine acetyltransferase 6A	Homo sapiens	22-25
4083034-4	1985	Plasma BuChE activity increase was found to be a common reaction after exposure to TCE, perchloroethylene, chloroform, methylene chloride and carbon tetrachloride and also after exposure to ethanol.	Methylene Chloride	119-137	butyrylcholinesterase	Mus musculus	7-12
3502566-2	1987	Self-association of peptides related to the 28-31 sequence of corticotropin releasing factor in methylene chloride was disrupted by adding a variety of polar organic solvents in increasing amounts.	Methylene Chloride	96-114	corticotropin releasing hormone	Homo sapiens	62-92
3771096-2	1986	Since this derivative is stable in trifluoroacetic acid:CH2 Cl2 (1:1) and anhydrous hydrogen fluoride, Boc-Cys(Npys) could be used directly in solid phase synthesis of the 14-peptide acetyl-Cys(Npys)-Gly-Glu-Gln-Gln-His-His-Pro-Gly-Gly-Gly-Ala-Lys-G ln-Ala-amide.	Methylene Chloride	56-63	BOC cell adhesion associated, oncogene regulated	Homo sapiens	103-106
4019026-2	1985	Self-association of peptides (related to the C-terminal sequence of porcine secretin) in methylene chloride was disrupted by adding dimethylsulfoxide in increasing amounts.	Methylene Chloride	89-107	secretin	Homo sapiens	76-84
2983307-2	1985	Using a receptor preparation of rabbit platelet membranes, we identified a novel antagonist of PAF in the methylene chloride extract of a Chinese herbal plant, haifenteng (Piper futokadsura).	Methylene Chloride	106-124	PCNA clamp associated factor	Homo sapiens	95-98
6732849-5	1984	The elastin-bound [14C]muzolimine was not extractable by organic solvents or by weak acids or bases but was released in a soluble form by pancreatic elastase and extracted from the elastase digest by dichloromethane.	Methylene Chloride	200-215	elastin	Rattus norvegicus	4-11
6501151-5	1984	BBA is oxidized with potassium dichromate to BBP, which is partitioned into dichloromethane and further cleaned up on a silica gel column before determination by GC with EC detection.	Methylene Chloride	76-91	transmembrane protein 158	Homo sapiens	45-48
6832887-4	1983	The 4-chloromethylphenoxyacetyl polystyrene resin was tested by the synthesis of Leu-enkephalin which was cleaved, at the end of the synthesis, from the solid support in 91% yield by 60% trifluoroacetic acid in methylene chloride, and was shown to be more than 99% pure by ion-exchange chromatography and reverse phase high pressure liquid chromatography.	Methylene Chloride	211-229	prodynorphin	Homo sapiens	81-95
6891469-6	1982	However, the findings of Experiment 3 showed that incubation of the aqueous layer from the third CH2Cl2 extraction in beta-glucuronidase can free additional aggression-promoting cues into a subsequent CH2Cl2 extraction.	Methylene Chloride	97-103	glucuronidase, beta	Mus musculus	118-136
6891469-6	1982	However, the findings of Experiment 3 showed that incubation of the aqueous layer from the third CH2Cl2 extraction in beta-glucuronidase can free additional aggression-promoting cues into a subsequent CH2Cl2 extraction.	Methylene Chloride	201-207	glucuronidase, beta	Mus musculus	118-136
13658958-1	1959	Dichloromethane and chloroform have been found to inhibit the action of liver beta-glucuronidase on phenolphthalein glucuronic acid at concentrations which produce a considerable enhancement of bacterial beta-glucuronidase.	Methylene Chloride	0-15	glucuronidase beta	Homo sapiens	78-96
7347821-3	1981	A significant difference was evidenced between AST and ALT levels in two firms, chiefly attributable to the quantity and quality of the substances utilized in the two technological cycles: trichloroethylene, chromium, sulphuric acid, mineral oils, ammonia, N-hexane, pentanes acetone, ciclo hexane, methanol, ethyl acetate, isopropyl acetate, toluene, methylene chloride.	Methylene Chloride	352-370	solute carrier family 17 member 5	Homo sapiens	47-50
6893397-3	1980	Administration of 0.15 mL/100 g/day CH2Cl2 to SHRs for five days reduced the BP from 172 +/- 7 mm Hg (mean +/- SEM) to 155 +/- 6 mm Hg without changing the plasma renin activity.	Methylene Chloride	36-42	renin	Rattus norvegicus	163-168
6287806-0	1982	Dose dependent induction of rat liver microsomal cytochrome P-450 and microsomal enzymatic activities after inhalation of toluene and dichloromethane.	Methylene Chloride	134-149	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	49-65
6126182-6	1982	Like the proton-translocating ATPase of mammalian mitochondria the granule enzyme when membrane-bound was inhibited by up to 85% by tributyltin or NN"-dicyclohexylcarbodi-imide and was solubilized in a tributyltin-insensitive form after extraction with dichloromethane.	Methylene Chloride	253-268	dynein axonemal heavy chain 8	Homo sapiens	30-36
7241514-8	1981	Removal of the tert-butyloxycarbonyl group, followed by reaction with N-maleoylglycine and DCC/HOBt in methylene chloride, gave cyclic tetrapeptide 5 in 68% yield.	Methylene Chloride	103-121	DCC netrin 1 receptor	Bos taurus	91-94
16345659-1	1980	Strain DM1, a facultative methylotrophic bacterium utilizing methanol, formate, mono-, di-, and trimethylamine, as well as dichloromethane as C1 substrates was isolated as an airborne contaminant.	Methylene Chloride	123-138	immunoglobulin heavy diversity 1-7	Homo sapiens	7-10
7430045-4	1980	The fat is eluted on a glass column, using dichloromethane-methanol (9+1).	Methylene Chloride	43-58	FAT atypical cadherin 1	Homo sapiens	4-7
965337-2	1976	Similar blue colors were obtained using SbCl3, CF3COOH, and CCl3COOH in solutions of CHCl3, CH2Cl2 and C2H4Cl2.	Methylene Chloride	92-98	C-C motif chemokine ligand 3	Homo sapiens	60-64
13832008-1	1960	Although the rate of hydrolysis by mammalian beta-glucuronidase appears to be inhibited by methylene chloride or carbon tetrachloride with the standard technique (phenolphthalein glucuronide as a substrate), the release of steroidal conjugates under conditions generally employed does not appear to be affected.	Methylene Chloride	91-109	glucuronidase beta	Homo sapiens	45-63
13658958-1	1959	Dichloromethane and chloroform have been found to inhibit the action of liver beta-glucuronidase on phenolphthalein glucuronic acid at concentrations which produce a considerable enhancement of bacterial beta-glucuronidase.	Methylene Chloride	0-15	glucuronidase beta	Homo sapiens	204-222
34035208-9	2021	However, dichloromethane demonstrated a high toxicity level with LC50 of 10.32+-0.13 mug/mL and a weak cytotoxic level against SK-OV-3 cell lines (IC50 of 560.86+-0.63 mug/mL).	Methylene Chloride	9-24	thrombopoietin	Mus musculus	89-91
34035208-9	2021	However, dichloromethane demonstrated a high toxicity level with LC50 of 10.32+-0.13 mug/mL and a weak cytotoxic level against SK-OV-3 cell lines (IC50 of 560.86+-0.63 mug/mL).	Methylene Chloride	9-24	thrombopoietin	Mus musculus	172-174
34035208-10	2021	Moreover, the dichloromethane and n-hexane extracts showed high and promising antiplasmodial activity with IC50 2.13+-0.42 and 6.51+-0.49 mug/mL, respectively.	Methylene Chloride	14-29	thrombopoietin	Mus musculus	142-144
33576602-1	2021	In this study, a commercially available homogeneous pincer-type complex, Ru-Macho, was directly heterogenized via the Lewis acid-catalyzed Friedel-Crafts reaction using dichloromethane as the cross-linker to obtain a heterogeneous, pincer-type Ru porous organometallic polymer (Ru-Macho-POMP) with a high surface area.	Methylene Chloride	169-184	proteasome maturation protein	Homo sapiens	287-291
33836115-1	2021	Enhancement of the luminescence efficiency of two new diazapentacenium salts ( D1 and D2 ) of more than 55 for D1 and 22 times for D2 ) in poor solvents, acetonitrile and/or dichloromethane, was observed and rationalized as formation of emissive J-aggregates.	Methylene Chloride	174-189	leiomodin 1	Homo sapiens	79-88
34040519-9	2021	In alpha-glucosidase inhibitory activity, maximum inhibition was observed in DCM and chloroform extracts of SBGC (>85% inhibition at 25% concentration), followed by KBGC (>80% inhibition at 25% concentration), JBGC and GC.	Methylene Chloride	77-80	sucrase isomaltase (alpha-glucosidase)	Mus musculus	3-20
33387565-5	2021	Dose-dependent toxicokinetics of DCM suggest that DCM is a threshold carcinogen in mice, initiating carcinogenicity via the low affinity/high capacity GSTT1 pathway; a biotransformation pathway that becomes relevant only at high exposure concentrations.	Methylene Chloride	33-36	glutathione S-transferase, theta 1	Mus musculus	151-156
33641047-7	2021	Encapsulation efficiencies of GDNF and TUDCA for the initial multiloaded MSs, prepared with methylene chloride (MC) as organic solvent and polyvinyl alcohol (PVA) solution in the external phase, were 28.53+-0.36% and 45.65+-8.01% respectively.	Methylene Chloride	92-110	glial cell derived neurotrophic factor	Homo sapiens	30-34
33641047-7	2021	Encapsulation efficiencies of GDNF and TUDCA for the initial multiloaded MSs, prepared with methylene chloride (MC) as organic solvent and polyvinyl alcohol (PVA) solution in the external phase, were 28.53+-0.36% and 45.65+-8.01% respectively.	Methylene Chloride	112-114	glial cell derived neurotrophic factor	Homo sapiens	30-34
33166626-5	2021	AIMS OF THE STUDY: (1) To perform a phytochemical investigation of the dichloromethane-methanol 1:1 extracts of the bark (ASB), roots (ASR), and leaves (ASL) from Araliopsis soyauxii; (2) to evaluate the cytotoxicity of extracts and isolated compounds; (3) to determine the mode of induction of apoptosis of ASB and kihadanin B (12).	Methylene Chloride	71-86	arylsulfatase B	Homo sapiens	122-125
33932831-7	2021	In the system with 500 mg/L of BaP and dichloromethane addition, the removal rate increased drastically (14.64 mg/(L d)) at 400 mg/L turn point of BaP.	Methylene Chloride	39-54	prohibitin 2	Homo sapiens	147-150
33387565-5	2021	Dose-dependent toxicokinetics of DCM suggest that DCM is a threshold carcinogen in mice, initiating carcinogenicity via the low affinity/high capacity GSTT1 pathway; a biotransformation pathway that becomes relevant only at high exposure concentrations.	Methylene Chloride	50-53	glutathione S-transferase, theta 1	Mus musculus	151-156
33025115-5	2020	Based on ESP maps, doping of Cr, Ti, Fe, and Ni is the cause of strong electrophilic region creation which is very useful for adsorption process CH2Cl2 and CHCl3 on nanocages.	Methylene Chloride	145-151	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	9-12
33480940-3	2021	In this work, we focus on a series of novel complexes of Ag(i) and Cu(i) with weakly basic ligands such as CH2Cl2, Cl3CCN and SO2 stabilized by perfluorinated alkoxyaluminate, Al[(ORF)4]-, RF = C(CF3)3.	Methylene Chloride	107-113	replication factor C subunit 1	Homo sapiens	189-201
33355566-0	2021	A non-luminescent polymorph of [(cyclohexyl isocyanide)2Au]PF6 that becomes luminescent upon grinding or exposure to dichloromethane vapor.	Methylene Chloride	117-132	sperm associated antigen 17	Homo sapiens	59-62
32677743-4	2020	Methylene chloride extract of MA (MEMA) decreased the migration of RAW264.7 cells and THP-1 macrophages toward cancer cells via inhibition of focal adhesion kinase and Src activity.	Methylene Chloride	0-18	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	168-171
33179699-2	2020	The reaction of the same aziridine-2-carboxaldehyde with three moles of indole in dichloromethane yielded tris-indole adducts beta-(3,3"-bisindolyl)methyl (BIM) tryptamines from sequential steps including nucleophilic addition to aldehyde, Michael type Friedel-Crafts alkylation of the mono-adduct followed by regio- and stereoselective ring-opening of the aziridine ring.	Methylene Chloride	82-97	glycoprotein A33	Homo sapiens	126-136
33086004-1	2020	The reaction of [Ni6(CO)12]2- as a [NBu4]+ salt in CH2Cl2 with 0.8 equiv of PCl3 afforded [Ni14P2(CO)22]2-.	Methylene Chloride	51-57	PHD finger protein 19	Homo sapiens	76-80
32180460-10	2020	After 24 h, we found increased levels of caspase-3 activation in cells treated with 25 mug/ml dichloromethane and hexane extracts compared to untreated cells.	Methylene Chloride	94-109	caspase 3	Homo sapiens	41-50
32957145-2	2020	In initial investigations, the dichloromethane extract from the aerial parts of S. orientalis showed distinct inhibitory effects on the release of interleukin-8 in human neutrophils.	Methylene Chloride	31-46	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
32702988-3	2020	This new approach exploits broad fluorescence from a charge-transfer (CT) state of BD1, which possesses: i) a significant Stokes shift of 181 nm in dichloromethane; and ii) a comparably-high CT-fluorescence quantum yield (Phiref=7.0+-0.2 %), which is independent from oxygen presence and quencher (perylene) concentration while also exhibiting a linear intensity dependence.	Methylene Chloride	148-163	defensin beta 1	Homo sapiens	83-86
33122979-5	2020	Cell death ELISA, TUNEL assay, and the cleavage of poly ADP-ribose polymerase (PARP) uncovered that the cytotoxic effects of dichloromethane and methanol extracts were attributed to apoptosis in cancerous cells.	Methylene Chloride	125-140	poly(ADP-ribose) polymerase 1	Homo sapiens	51-77
33122979-5	2020	Cell death ELISA, TUNEL assay, and the cleavage of poly ADP-ribose polymerase (PARP) uncovered that the cytotoxic effects of dichloromethane and methanol extracts were attributed to apoptosis in cancerous cells.	Methylene Chloride	125-140	poly(ADP-ribose) polymerase 1	Homo sapiens	79-83
32790354-4	2020	The aryl hydrocarbon (AhR) and pregnane X (PXR) transcription factors showed the greatest upregulation; with HLB exceeding DCM-total, and no upregulation in the hydrocarbon fraction (DCM-SGC).	Methylene Chloride	123-126	aryl hydrocarbon receptor	Homo sapiens	22-25
32790354-4	2020	The aryl hydrocarbon (AhR) and pregnane X (PXR) transcription factors showed the greatest upregulation; with HLB exceeding DCM-total, and no upregulation in the hydrocarbon fraction (DCM-SGC).	Methylene Chloride	123-126	nuclear receptor subfamily 1 group I member 2	Homo sapiens	43-46
32845253-1	2020	New dipyridylpyrrole N-oxide ligands HL1 and HL2 are designed and synthesized via oxidation of 2-(5-(pyridin-2-yl)-1H-pyrrol-2-yl)pyridine (Hdpp) by using 3-chloroperbenzoic acid (m-CPBA) in CH2Cl2.	Methylene Chloride	191-197	asialoglycoprotein receptor 1	Homo sapiens	37-40
32845253-1	2020	New dipyridylpyrrole N-oxide ligands HL1 and HL2 are designed and synthesized via oxidation of 2-(5-(pyridin-2-yl)-1H-pyrrol-2-yl)pyridine (Hdpp) by using 3-chloroperbenzoic acid (m-CPBA) in CH2Cl2.	Methylene Chloride	191-197	intelectin 2	Homo sapiens	45-48
33117569-1	2020	Tri-ethyl-ammonium hexa-bromido-uranate(IV) di-chloro-methane monosolvate, [(C2H5)3NH]2[UBr6] CH2Cl2, was obtained in the form of dark-brown crystals from the reaction of uranium penta-bromide with NEt3 and ethyl-ene glycol in di-chloro-methane at low temperature.	Methylene Chloride	44-61	hexosaminidase subunit alpha	Homo sapiens	19-23
33117569-1	2020	Tri-ethyl-ammonium hexa-bromido-uranate(IV) di-chloro-methane monosolvate, [(C2H5)3NH]2[UBr6] CH2Cl2, was obtained in the form of dark-brown crystals from the reaction of uranium penta-bromide with NEt3 and ethyl-ene glycol in di-chloro-methane at low temperature.	Methylene Chloride	44-61	F-box protein 11	Homo sapiens	88-92
33117569-1	2020	Tri-ethyl-ammonium hexa-bromido-uranate(IV) di-chloro-methane monosolvate, [(C2H5)3NH]2[UBr6] CH2Cl2, was obtained in the form of dark-brown crystals from the reaction of uranium penta-bromide with NEt3 and ethyl-ene glycol in di-chloro-methane at low temperature.	Methylene Chloride	44-61	tetraspanin 2	Homo sapiens	198-202
30600731-5	2020	Maximum larvicidal activity of 85.83% was recorded in the dichloromethane fraction (LC50 = 469.78 microg mL-1).	Methylene Chloride	58-73	L1 cell adhesion molecule	Mus musculus	105-109
32702988-4	2020	Based on this, we developed an upconversion reference using the BD1 sensitizer mixed with perylene (1x10-5 M/1x10-4 M) in dichloromethane.	Methylene Chloride	122-137	defensin beta 1	Homo sapiens	64-67
32784977-8	2020	Furthermore, the anthraquinone-rich dichloromethane fraction displayed the highest anticancer activity when evaluated in a human hepatoma cancer cell line (HepG2), in which it induced increased apoptosis mediated by p53 and caspase activation.	Methylene Chloride	36-51	tumor protein p53	Homo sapiens	216-219
32751738-0	2020	Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1beta-Driven Neuroinflammation in BV2 Microglial Cells.	Methylene Chloride	18-36	interleukin 1 alpha	Mus musculus	57-65
32525176-3	2020	Reactions in dichloromethane yield the diolate (Hap)2Os(OCH2CH2O).	Methylene Chloride	13-28	BAG cochaperone 1	Homo sapiens	48-51
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Methylene Chloride	2-17	frizzled related protein	Homo sapiens	27-30
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Methylene Chloride	2-17	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Methylene Chloride	2-17	tumor necrosis factor	Homo sapiens	181-190
32326068-6	2020	n-Hexane- and dichloromethane-based extracts of Garcinia cambogia efficiently suppressed 5-LO activity in human neutrophils (IC50 = 0.92 and 1.39 microg/mL), and potently inhibited isolated human 5-LO (IC50 = 0.15 and 0.16 microg/mL) and mPGES-1 (IC50 = 0.29 and 0.49 microg/mL).	Methylene Chloride	14-29	prostaglandin E synthase	Mus musculus	238-245
32186860-1	2020	The reaction of PMe3 or PPh3 with PF5 in anhydrous CH2Cl2 or hexane forms the white, moisture-sensitive complexes [PF5(PR3)] (R = Me, Ph).	Methylene Chloride	51-57	protein phosphatase 4 catalytic subunit	Homo sapiens	24-28
32002826-9	2020	CONCLUSIONS: In this SAR study, a 5-HT1A selective ligand has been identified in which a tetralone moiety replaced the 1,4-benzodioxane of spiroxatrine and the methylene linker to the triazaspirodecanone portion was maintained in position 2.	Methylene Chloride	160-169	5-hydroxytryptamine receptor 1A	Homo sapiens	34-40
32188443-9	2020	RESULTS: Amongst 14 different leaf extracts investigated, extracts prepared by ultrasonication in dichloromethane and maceration in ethanol were most active in inhibiting TNF-alpha and IL-1beta production in human U937 macrophages.	Methylene Chloride	98-113	tumor necrosis factor	Homo sapiens	171-180
32188443-9	2020	RESULTS: Amongst 14 different leaf extracts investigated, extracts prepared by ultrasonication in dichloromethane and maceration in ethanol were most active in inhibiting TNF-alpha and IL-1beta production in human U937 macrophages.	Methylene Chloride	98-113	interleukin 1 alpha	Homo sapiens	185-193
32143618-5	2020	RESULTS: Test of the dichloromethane fraction of the methanolic extract of C. droserifolia, (CDD) revealed potent cytotoxic activity (from 70 to 90%) against several human cancer cell lines, including MCF-7, MDA-MB-231, and HeLa.	Methylene Chloride	21-36	natriuretic peptide A	Homo sapiens	93-96
32007923-5	2020	In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components.	Methylene Chloride	20-35	interleukin 1 alpha	Homo sapiens	46-54
32007923-5	2020	In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components.	Methylene Chloride	20-35	tumor necrosis factor	Homo sapiens	151-184
31673948-4	2019	The signal level recorded for RDX upon adduction to the radical anion of 1,4-benzoquinone under our experimental conditions was significantly higher than that realized by chloride adduction using dichloromethane (DCM) as the dopant.	Methylene Chloride	196-211	radixin	Homo sapiens	30-33
31679890-4	2020	The removal efficiency of methylene blue (MB, 50 mg L-1) achieves ~100% within 2 min.	Methylene Chloride	26-35	L1 cell adhesion molecule	Homo sapiens	52-55
31630030-4	2020	For achieving sensitive detection of MnSOD gene, the methylene blue (MB)-modified capture probe (CP) as the inner reference element was first self-assembled on triangular Au nanosheets modified paper working electrode to provide a built-in correction and improve the detection accuracy.	Methylene Chloride	53-62	superoxide dismutase 2	Homo sapiens	37-42
32193761-5	2020	Sex-stratified conditional logistic regression analyses revealed higher adjusted odds of ALS for men with exposure to benzene (aOR = 1.20; 95% CI 1.02, 1.41) and methylene chloride (aOR = 1.23; 95% CI 1.07, 1.42).	Methylene Chloride	162-180	superoxide dismutase 1	Homo sapiens	89-92
32193761-8	2020	Our study suggests an increased risk of ALS in men exposed to multiple solvents, with the greatest influence being from methylene chloride.	Methylene Chloride	120-138	superoxide dismutase 1	Homo sapiens	40-43
31738060-1	2020	An N-phenylbenzimidazole constrained in a coplanar fashion with a methylene tether (IMAC) was designed and used to prepare a series of emitters exhibiting thermally activated delayed fluorescence (TADF).	Methylene Chloride	66-82	C-C motif chemokine ligand 26	Homo sapiens	84-88
31920428-10	2020	Cytosolic isoenzymes of human carbonic anhydrase (hCA) I, and II isoenzymes were influentially suppressed by flower and fruit dichloromethane fractions with 1.650 and 2.020 microM IC50 values, respectively.	Methylene Chloride	126-141	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	30-64
31804076-0	2019	Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analog with Enhanced Stability.	Methylene Chloride	44-64	insulin	Homo sapiens	71-78
31804076-4	2019	To address this limitation, we chemically synthesized and evaluated a methylene thioacetal human insulin analog (SCS-Ins).	Methylene Chloride	70-90	insulin	Homo sapiens	97-104
31843022-3	2019	This study assessed if methylene blue (MB), a phenothiazine that inhibits caspases, alters Caspase-6-induced neurodegeneration and cognitive impairment in mice.	Methylene Chloride	23-32	caspase 6	Homo sapiens	74-82
31843022-3	2019	This study assessed if methylene blue (MB), a phenothiazine that inhibits caspases, alters Caspase-6-induced neurodegeneration and cognitive impairment in mice.	Methylene Chloride	23-32	caspase 6	Mus musculus	91-100
31802755-2	2019	Macrocycles containing imidazolin-2-ylidene groups formed the monometallic complex [(1,2,5,6-eta)-cycloocta-1,5-diene](5,16-dibenzyl-1,5,9,12,16,20-hexaazatricyclo[18.2.1.19,12]tetracosa-10,21-dien-21,22-diylidene)iridium(I) bromide dichloromethane monosolvate, [Ir(C8H12)(C32H42N6)]Br CH2Cl2, 2a.	Methylene Chloride	174-260	endothelin receptor type A	Homo sapiens	67-70
31577968-4	2019	Methylene blue (MB) as a redox probe was absorbed on IFN-gamma aptamer.	Methylene Chloride	0-9	interferon gamma	Homo sapiens	53-62
31673948-4	2019	The signal level recorded for RDX upon adduction to the radical anion of 1,4-benzoquinone under our experimental conditions was significantly higher than that realized by chloride adduction using dichloromethane (DCM) as the dopant.	Methylene Chloride	213-216	radixin	Homo sapiens	30-33
32095038-11	2019	DCM extracts decreased the relative number of NF-kappaB+ cells (125 mg/kg: 13.96+-0.84%).	Methylene Chloride	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	46-55
32095038-14	2019	DCM extracts reduced iNOS expression (especially at 125 mg/kg).	Methylene Chloride	0-3	nitric oxide synthase 2, inducible	Mus musculus	21-25
31666507-4	2019	The results provide direct evidence that diamond surfaces are coated by sp2-, and sp3-bonded amorphous carbon and functional groups of carboxylic acids (e.g., carboxyl, carboxylate, methyl, and methylene), indicating the geosynthesis of organic compounds in deep hydrous fluids.	Methylene Chloride	194-203	Sp3 transcription factor	Homo sapiens	82-85
31657577-8	2019	With the modified poly(caffeic acid) layer, SP-2 exhibited a different adsorption properties for Methylene Blue (MB, 180 mumol/g) to SP-1(~0 mumol/g), indicating that the tailorable structures of sponge can regulate their selectivity to guest molecules.	Methylene Chloride	97-106	Sp2 transcription factor	Homo sapiens	44-48
31584597-2	2019	The beta-CDHN presented a maximum adsorption capacity of 2080.35, 427.35 and 120.48 mg g-1 towards the cationic dye methylene blue (MB), heavy metal ions (Pb2+) and bisphenol A (BPA), respectively, much higher than those of many other adsorbents.	Methylene Chloride	116-125	cadherin 2	Homo sapiens	9-13
31595752-5	2019	Ru2 exhibited very strong solvatochromism from a visible emission maximum at 588 nm in CH2Cl2 to the near-IR region at 700 nm in water and singlet oxygen generation yield in water (23%) and DNA binding properties (intercalative DNA binding constant on the order of 106 M-1) comparable to those of Ru1, which should make Ru2 attractive for the aforementioned applications of Ru1 if the water solubility of Ru2 can be improved enough for the studies above.	Methylene Chloride	87-93	doublecortin domain containing 2	Homo sapiens	0-3
31588297-6	2019	Compared with the commercially available methylene blue (MB), syn-5al exhibits a better ability (Phi Delta = 0.61) to sensitize singlet oxygen (1O2) when irradiated with a 680 nm laser beam, and has potential as a photodynamic therapy (PDT) photosensitizer in the body"s therapeutic window (650-900 nm).	Methylene Chloride	41-50	syntrophin gamma 2	Homo sapiens	62-67
31226564-15	2019	CONCLUSIONS: Some non-metallic air toxics, particularly methylene chloride, were associated with the hazard for overall and ER+ breast cancer.	Methylene Chloride	56-74	epiregulin	Homo sapiens	124-126
31247800-2	2019	The reaction proceeds in dichloromethane under mild conditions, providing an efficient and general entry to gamma- or delta-CF3-substituted nitriles via tandem N-O and C(sp2)-C(sp3) bond cleavage and C(sp3)-CF3 bond formation.	Methylene Chloride	25-40	Sp2 transcription factor	Homo sapiens	168-173
30963643-6	2019	The relative activities of {[Ni](PF6 )}2 and [M](PF6 ) toward disproportionation are related to the electrochemically estimated Kdis values in CH2 Cl2 and DMF.	Methylene Chloride	143-150	sperm associated antigen 17	Homo sapiens	33-36
30963643-6	2019	The relative activities of {[Ni](PF6 )}2 and [M](PF6 ) toward disproportionation are related to the electrochemically estimated Kdis values in CH2 Cl2 and DMF.	Methylene Chloride	143-150	sperm associated antigen 17	Homo sapiens	49-52
31141826-5	2019	The antioxidant markers and acetylcholinesterase (AChE) inhibiting effect of DCM were also investigated.The results obtained from the behavioural study indicates that the DCM fraction significantly (p&lt;0.05) increased alternation behaviour of mice in the YMT, decreased the escape latency in the MWM paradigm and decreased the transfer latency in the EPM.	Methylene Chloride	77-80	acetylcholinesterase	Mus musculus	28-48
31141826-5	2019	The antioxidant markers and acetylcholinesterase (AChE) inhibiting effect of DCM were also investigated.The results obtained from the behavioural study indicates that the DCM fraction significantly (p&lt;0.05) increased alternation behaviour of mice in the YMT, decreased the escape latency in the MWM paradigm and decreased the transfer latency in the EPM.	Methylene Chloride	77-80	acetylcholinesterase	Mus musculus	50-54
31141826-5	2019	The antioxidant markers and acetylcholinesterase (AChE) inhibiting effect of DCM were also investigated.The results obtained from the behavioural study indicates that the DCM fraction significantly (p&lt;0.05) increased alternation behaviour of mice in the YMT, decreased the escape latency in the MWM paradigm and decreased the transfer latency in the EPM.	Methylene Chloride	171-174	acetylcholinesterase	Mus musculus	28-48
31141826-6	2019	Biochemically, DCM increased glutathione, and superoxide dismutase, but decreased malondialdehyde and AChE activity in the brain.The findings therefore suggests that the DCM possesses significant memory enhancing activity, which may be due to enhancement of antioxidant activity and cholinergic transmission.	Methylene Chloride	15-18	acetylcholinesterase	Mus musculus	102-106
31141826-6	2019	Biochemically, DCM increased glutathione, and superoxide dismutase, but decreased malondialdehyde and AChE activity in the brain.The findings therefore suggests that the DCM possesses significant memory enhancing activity, which may be due to enhancement of antioxidant activity and cholinergic transmission.	Methylene Chloride	170-173	acetylcholinesterase	Mus musculus	102-106
31318987-4	2019	DFT studies of the potential energy surface (B3LYP/6-31+G(d)+CPCM (dichloromethane)) of the reaction correlate the activity of different catalysts and support an intramolecular hydrogen-bond-assisted activation of the squaramide moiety in the transition state of the catalytic reaction.	Methylene Chloride	67-82	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	47-50
31367714-4	2019	The reaction of [Ru(OAc)2(CO)(PPh3)2] with PP in CH2Cl2 or toluene affords the fluxional acetate derivatives [Ru(OAc)2(CO)(PP)] (PP = dppb 11, dppf 12, (R)-BINAP 13, and (R,R)-Skewphos 14).	Methylene Chloride	49-55	caveolin 1	Homo sapiens	30-34
31368475-6	2019	The treatment of macrocyclic-bis(NHC)silver(i) complexes 4a and 4b with one equivalent of PdCl2(MeCN)2 in methylene chloride afforded square-planar trans-macrocyclic-bis(NHC)Pd(ii)X2 complexes 5a and 5b.	Methylene Chloride	106-124	phosducin like 2	Homo sapiens	90-102
31430123-4	2019	Luminescent investigations reveal that Ag3-iah can selectively detect dichloromethane or trichloromethane in tetrachloromethane.	Methylene Chloride	70-85	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	39-42
30768111-3	2019	Exposure to air of dichloromethane solutions of complexes 1 and 2 produced dioxygen derivatives [Os(eta5-C5Me5)(eta2-O2)(PPh3){P(OR)3}]BPh4 (10, 11) [R = Me (10), Et (11)].	Methylene Chloride	19-34	caveolin 1	Homo sapiens	121-125
30963643-3	2019	The complexes [Pd](PF6 ) and [Pt](PF6 ) adopt monomeric structures and are stable in CH2 Cl2 and toluene, whereas they gradually disproportionate at room temperature to [M] and 3,5-di-tert-butylbenzoquinone (3,5-DTBBQ) in polar solvents such as THF, MeOH, EtOH, DMF, or DMSO.	Methylene Chloride	85-92	sperm associated antigen 17	Homo sapiens	19-22
30963643-3	2019	The complexes [Pd](PF6 ) and [Pt](PF6 ) adopt monomeric structures and are stable in CH2 Cl2 and toluene, whereas they gradually disproportionate at room temperature to [M] and 3,5-di-tert-butylbenzoquinone (3,5-DTBBQ) in polar solvents such as THF, MeOH, EtOH, DMF, or DMSO.	Methylene Chloride	85-92	sperm associated antigen 17	Homo sapiens	34-37
30681097-5	2019	For example, PDI-TAB forms fibers of finite length when bulk powder is dispersed in methanol; it shows flexible lengthy 1D fibers when dichloromethane solution of PDI-TAB is injected into methanol solvent.	Methylene Chloride	135-150	peptidyl arginine deiminase 1	Homo sapiens	13-16
30681097-5	2019	For example, PDI-TAB forms fibers of finite length when bulk powder is dispersed in methanol; it shows flexible lengthy 1D fibers when dichloromethane solution of PDI-TAB is injected into methanol solvent.	Methylene Chloride	135-150	peptidyl arginine deiminase 1	Homo sapiens	163-166
30994355-5	2019	Intriguingly, the reaction coordinates of this redox-driven structural change have strong dependence on the environment, such as the solvent (THF vs CH2Cl2) and supporting electrolyte (PF6- vs B(C6F5)4-).	Methylene Chloride	149-155	sperm associated antigen 17	Homo sapiens	185-188
30978009-7	2019	Compound 4 was also obtained from 5 by heating to 110  C for 24 h. The reaction of 1 with 2,5-dimethylfuran (DMFUR) in CH2Cl2 at 40  C yielded the new compound [Re2(CO)8(mu-eta2-3,2-(CH3)2C4H2O)](mu-H) (6), which contains a bridging (sigma + pi)-coordinated 2,5-dimethylfuryl ligand formed by activation of the C-H bond at the 3 position of DMFUR.	Methylene Chloride	119-125	G protein-coupled receptor 161	Homo sapiens	161-164
30859832-2	2019	The reaction of geranyl derivatives with N-bromosuccinimide (NBS) proceeds rapidly in CH2Cl2 to give the corresponding bromocyclization products in high yields as a ca.	Methylene Chloride	86-92	nibrin	Homo sapiens	61-64
30921647-12	2019	The DCM extract was most active for phosphomolybdenum and alpha-glucosidase inhibition assays.	Methylene Chloride	4-7	sucrase-isomaltase	Homo sapiens	58-75
30958872-4	2019	The results indicated that DCM-mediated significant (p&lt;0.05) increases in serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase and alkaline phosphatase activities as well as urea and creatinine levels were dose-dependently normalized to the control values in rats co-treated with quercetin.	Methylene Chloride	27-30	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	109-135
30958872-4	2019	The results indicated that DCM-mediated significant (p&lt;0.05) increases in serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase and alkaline phosphatase activities as well as urea and creatinine levels were dose-dependently normalized to the control values in rats co-treated with quercetin.	Methylene Chloride	27-30	gamma-glutamyltransferase 1	Rattus norvegicus	137-163
30958872-5	2019	Further, quercetin co-treatment ameliorated DCM-mediated decrease in the hepatic and renal activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase as well as glutathione level in the treated rats.	Methylene Chloride	44-47	catalase	Rattus norvegicus	127-135
30958872-5	2019	Further, quercetin co-treatment ameliorated DCM-mediated decrease in the hepatic and renal activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase as well as glutathione level in the treated rats.	Methylene Chloride	44-47	hematopoietic prostaglandin D synthase	Rattus norvegicus	164-189
31745533-4	2019	Through a series of reactions catalyzed by cytochrome P450 2E1 (CYP2E1), metabolism of methylene chloride leads to the formation of formyl chloride, and ultimately carbon monoxide (CO).	Methylene Chloride	87-105	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	43-62
31459328-3	2019	It reacts with CH2Cl2 to give a mixture of isomers of [PtMe2(CH2Cl)(kappa3-N,N",O-(L1-H)], 6, and decomposes in acetone to give [PtMe3(kappa3-N,N",O-(L1-H)], 7, both of which contain the fac tridentate deprotonated ligand.	Methylene Chloride	15-21	FA complementation group C	Homo sapiens	187-190
30733449-2	2019	Here we report on two stable 17-electron [Cr(CO)6] + salts that were synthesized by oxidation of Cr(CO)6 with [NO]+[Al(ORF)4]- (RF = C(CF3)3)) in CH2Cl2 and with removal of NO gas.	Methylene Chloride	146-152	replication factor C subunit 1	Homo sapiens	128-141
31745533-4	2019	Through a series of reactions catalyzed by cytochrome P450 2E1 (CYP2E1), metabolism of methylene chloride leads to the formation of formyl chloride, and ultimately carbon monoxide (CO).	Methylene Chloride	87-105	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	64-70
30351014-4	2018	CH2Cl2 adducts formed by displacement of the eta1-alkanes in solution ( n = 5; L = NBA, COA), [ RhH(Cy2P(CH2)2( CH)(CH2)2PCy2)(kappa1-ClCH2Cl)][BArF4], are characterized crystallographically.	Methylene Chloride	0-6	secreted phosphoprotein 1	Homo sapiens	45-49
30318864-5	2018	The exposure of V12-free to the guest molecule vapors of CH2 Cl2 , 1,2-dichloroethane, MeNO2 , MeCN, and MeBr resulted in the selective insertion of the guest to reform the guest-inserted V12 structure.	Methylene Chloride	57-64	immunoglobulin lambda variable 2-8	Homo sapiens	16-19
30318864-5	2018	The exposure of V12-free to the guest molecule vapors of CH2 Cl2 , 1,2-dichloroethane, MeNO2 , MeCN, and MeBr resulted in the selective insertion of the guest to reform the guest-inserted V12 structure.	Methylene Chloride	57-64	immunoglobulin lambda variable 2-8	Homo sapiens	188-191
30193010-1	2018	In an initial screening, the dichloromethane extract from the leaves of Melodorum fruticosum showed distinct inhibitory effects on the release of interleukin-8 (IL-8) in human neutrophils.	Methylene Chloride	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
30222350-10	2018	First we study the SN2 nucleophilic substitution reaction of a Cl in CH2Cl2 leading to an understanding of the kinetic origin of the chirality inversion in such processes.	Methylene Chloride	69-75	solute carrier family 38 member 5	Homo sapiens	19-22
29727733-9	2018	RESULTS: The dichloromethane extract of L. zeylanica efficiently inhibited 5-LO activity in stimulated human neutrophils (IC50 = 5.5 microg/mL) and isolated human 5-LO and mPGES-1 (IC50 = 2.2 and 0.4 microg/mL).	Methylene Chloride	13-28	arachidonate 5-lipoxygenase	Homo sapiens	75-79
29727733-9	2018	RESULTS: The dichloromethane extract of L. zeylanica efficiently inhibited 5-LO activity in stimulated human neutrophils (IC50 = 5.5 microg/mL) and isolated human 5-LO and mPGES-1 (IC50 = 2.2 and 0.4 microg/mL).	Methylene Chloride	13-28	arachidonate 5-lipoxygenase	Homo sapiens	163-167
29727733-9	2018	RESULTS: The dichloromethane extract of L. zeylanica efficiently inhibited 5-LO activity in stimulated human neutrophils (IC50 = 5.5 microg/mL) and isolated human 5-LO and mPGES-1 (IC50 = 2.2 and 0.4 microg/mL).	Methylene Chloride	13-28	prostaglandin E synthase	Mus musculus	172-179
29227091-2	2018	In this study, we surprisingly found that, under vacuum-UV (VUV) excitation, a gaseous mixture of CH2Cl2/H2O/analyte (OVOCs) in N2 buffer generated large amounts of H3O+ and protonated analyte even when the photon energy was lower than the ionization energy of the neutral species involved.	Methylene Chloride	98-104	H3 clustered histone 15	Homo sapiens	165-168
29220048-2	2017	The 5"-benzoylated complex without any other substituents exhibited phosphorescence-based monomer emission at 479 nm in dichloromethane (10 muM, rt) with a PL quantum yield of 0.28.	Methylene Chloride	120-135	latexin	Homo sapiens	140-143
28901170-1	2018	This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activity.	Methylene Chloride	103-118	butyrylcholinesterase	Homo sapiens	297-311
30152480-2	2018	A solution of [IrCl(IMes)(COD)] in dichloromethane reacts with H2 and Qu to form [IrCl(H)2(IMes)(Qu)2] (2).	Methylene Chloride	35-50	relaxin 2	Homo sapiens	63-72
30093114-5	2018	Amongst extracts and fractions of G. uralensis, methyl dichloride (MeCl2) fraction was the most effective to induce expression of uncoupling protein 1 (UCP1), a fat browning marker, in 3T3-L1 adipocytes.	Methylene Chloride	67-72	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	152-156
30019726-3	2018	Differential pulse voltammetry (DPV) in CH2Cl2/[n-Bu4N][PF6], demonstrated that the redox potential difference between the two 1e- FeIII/II couples (DeltaE1/2) is between 112 mV and 146 mV, being most pronounced with the electron rich Cp*2Ti(C2Fc)2CuBr.	Methylene Chloride	40-46	sperm associated antigen 17	Homo sapiens	56-59
30019726-5	2018	For each complex with a measurable DeltaE1/2 value, spectroelectrochemical experiments were performed in CH2Cl2/[n-Bu4N][PF6] and gave clear evidence of both the one-electron oxidized mixed-valent (MV) state and the two-electron oxidized state, each with distinct spectroscopic signatures.	Methylene Chloride	105-111	sperm associated antigen 17	Homo sapiens	121-124
29985607-2	2018	When carried out in the presence of CCl4 or Cl2C CCl2 (CH2Cl2 solutions, room temperature or below), the reaction furnishes the monocarbanion [C(SiCl3)3]- ([A]-; 92%) or the vicinal dianion [(Cl3Si)2C-C(SiCl3)2]2- ([B]2-; 85%) in excellent yields.	Methylene Chloride	55-61	C-C motif chemokine ligand 4	Homo sapiens	36-40
30200732-5	2018	Petroleum ether fraction and dichloromethane fraction of P. lingua from Guizhou province can reduce renal oxalic acid and renal calcium concentration, increase urinary oxalic acid and urine calcium, with significant inhibitory effect on the formation of renal calculus in rats, significantly increase SOD and CAT activities in renal tissues, and significantly reduce MDA levels.	Methylene Chloride	29-44	catalase	Rattus norvegicus	309-312
29771459-2	2018	The influence of the solvent (HCN, CH2 Cl2 , and aromatic hydrocarbons) on the crystallization process was studied, revealing dimer formation when using HCN or CH2 Cl2 as solvent, whereas aromatic hydrocarbons led to the formation of monomeric arene  HCN-B(C6 F5 )3 adducts, additionally stabilized by eta6 -coordination of the aromatic ring system similar to well-known half-sandwich complexes.	Methylene Chloride	35-42	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	153-156
29771459-2	2018	The influence of the solvent (HCN, CH2 Cl2 , and aromatic hydrocarbons) on the crystallization process was studied, revealing dimer formation when using HCN or CH2 Cl2 as solvent, whereas aromatic hydrocarbons led to the formation of monomeric arene  HCN-B(C6 F5 )3 adducts, additionally stabilized by eta6 -coordination of the aromatic ring system similar to well-known half-sandwich complexes.	Methylene Chloride	35-42	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	153-156
29771459-2	2018	The influence of the solvent (HCN, CH2 Cl2 , and aromatic hydrocarbons) on the crystallization process was studied, revealing dimer formation when using HCN or CH2 Cl2 as solvent, whereas aromatic hydrocarbons led to the formation of monomeric arene  HCN-B(C6 F5 )3 adducts, additionally stabilized by eta6 -coordination of the aromatic ring system similar to well-known half-sandwich complexes.	Methylene Chloride	160-167	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	30-33
29710525-3	2018	The current study aimed to evaluate the effect of crude extract, butanol, and dichloromethane fractions from BA on the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK-JNK) pathway in experimental diabetic rats.	Methylene Chloride	78-93	mitogen-activated protein kinase 9	Rattus norvegicus	176-180
29710525-3	2018	The current study aimed to evaluate the effect of crude extract, butanol, and dichloromethane fractions from BA on the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK-JNK) pathway in experimental diabetic rats.	Methylene Chloride	78-93	mitogen-activated protein kinase 8	Rattus norvegicus	181-184
29748474-12	2018	In conclusion, lipophilic constituents of DEPs extracted by n-hexane and DCM seem to induce rapid AhR-dependent [Ca2+]i increase in HMEC-1 endothelial cells, possibly involving both ROCE and SOCE-mediated mechanisms.	Methylene Chloride	73-76	aryl hydrocarbon receptor	Homo sapiens	98-101
29748474-13	2018	The semi-lipophilic fraction extracted by DCM also caused an AhR-dependent reduction in global membrane order, which appeared to be connected to the [Ca2+]i increase.	Methylene Chloride	42-45	aryl hydrocarbon receptor	Homo sapiens	61-64
29498521-4	2018	M06-2X functional was found to perform best and applied to systematically explore the trends in reactivity for halides (F- and Cl-) and simple amines toward the substrates NH2Cl and NHCl2 (SN2@N) as well as CH3Cl and CH2Cl2 (SN2@C).	Methylene Chloride	217-223	solute carrier family 38 member 5	Homo sapiens	225-228
29073346-1	2017	Direct experimental determination of redox properties of superoxo (O2.- ) and peroxo (O22- ) embedded in dicopper complexes bearing an unsymmetrical binucleating ligand was achieved using cryo-electrochemistry and cryo-spectroelectrochemistry in dichloromethane.	Methylene Chloride	246-261	immunoglobulin kappa variable 1D-39	Homo sapiens	67-71
28972884-3	2017	In this study, the mechanism underlying the anti-cancer effects of a dichloromethane fraction of TA (TDF) was investigated in vitro and in vivo.	Methylene Chloride	69-84	sex determining region of Chr Y	Mus musculus	101-104