PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28070831-6 2017 RESULTS: POP-specific inhibitors 3-({4-[2-(E)-styrylphenoxy]butanoyl}-L-4-hydroxyprolyl)-thiazolidine (SUAM-14746) and benzyloxycarbonyl-thiopropyl-thioprolinal and RNAi-mediated POP knockdown inhibited the proliferation of MCF7 cells without inducing cell death. suam 103-107 prolyl endopeptidase Homo sapiens 9-12 1812006-6 1991 However, two of the compounds, SUAM-1221 and its amine derivative, had ED50S versus mouse brain PEP (1-3 mg/kg) an order of magnitude less than the other compounds (25-40 mg/kg). suam 31-35 prolyl endopeptidase Mus musculus 96-99 28070831-6 2017 RESULTS: POP-specific inhibitors 3-({4-[2-(E)-styrylphenoxy]butanoyl}-L-4-hydroxyprolyl)-thiazolidine (SUAM-14746) and benzyloxycarbonyl-thiopropyl-thioprolinal and RNAi-mediated POP knockdown inhibited the proliferation of MCF7 cells without inducing cell death. suam 103-107 prolyl endopeptidase Homo sapiens 179-182 24269815-5 2014 POP specific inhibitors, 3-({4-[2-(E)-styrylphenoxy]butanoyl}-l-4-hydroxyprolyl)-thiazolidine (SUAM-14746) and benzyloxycarbonyl-thioprolyl-thioprolinal, or RNAi-mediated POP knockdown inhibited the growth of KATO III cells irrespective of their p53 status. suam 95-99 prolyl endopeptidase Homo sapiens 0-3 28070831-9 2017 Moreover, the SUAM-14746-mediated cell cycle arrest of MCF7 cells was associated with increased pRb2/p130 protein expression and an increase in the number of cells in the quiescent G0 state, as defined by low RNA levels. suam 14-18 proline rich protein BstNI subfamily 2 Homo sapiens 96-100 28070831-9 2017 Moreover, the SUAM-14746-mediated cell cycle arrest of MCF7 cells was associated with increased pRb2/p130 protein expression and an increase in the number of cells in the quiescent G0 state, as defined by low RNA levels. suam 14-18 RB transcriptional corepressor like 2 Homo sapiens 101-105 28487025-10 2017 CONCLUSION: The dose-dependent effect of SUAM-14746 on TSCs suggests that Prep plays an important role in the differentiation into SpTs and TGCs in the mouse placenta. suam 41-45 prolyl endopeptidase Mus musculus 74-78