PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1337198-6	1992	CAP (75 micrograms/15 microliters of 20% 2-hydroxypropyl-beta-cyclodextrin) resulted in an equal reduction (40-50%) in the dorsal horn levels of sP and CGRP, but not VIP.	2-Hydroxypropyl-beta-cyclodextrin	41-74	calcitonin-related polypeptide alpha	Rattus norvegicus	152-156
8376357-4	1993	In rat adipocytes, CD also enhanced the translocation of protein kinase C (PKC)-beta to the plasma membrane during the action of phorbol esters, which alone had little or no effect on this specific PKC translocation.	2-Hydroxypropyl-beta-cyclodextrin	19-21	protein kinase C, beta	Rattus norvegicus	57-84
8376357-4	1993	In rat adipocytes, CD also enhanced the translocation of protein kinase C (PKC)-beta to the plasma membrane during the action of phorbol esters, which alone had little or no effect on this specific PKC translocation.	2-Hydroxypropyl-beta-cyclodextrin	19-21	protein kinase C, gamma	Rattus norvegicus	75-78
8376357-5	1993	Although it is uncertain how CD alters the function of plasma membranes to enhance the translocation of PKC-beta to, and the activation of glucose transporters within, this subcellular fraction during phorbol ester treatment, our findings provide direct support for a two-step model in the activation of glucose transport.	2-Hydroxypropyl-beta-cyclodextrin	29-31	protein kinase C, beta	Rattus norvegicus	104-112
2367328-1	1990	A series of hydroxypropyl-beta-cyclodextrins was prepared by a method that leads to a preferential substitution on the secondary hydroxyls, mainly O-2, of beta-cyclodextrin with (S)-2-hydroxypropyl groups.	2-Hydroxypropyl-beta-cyclodextrin	12-44	immunoglobulin kappa variable 1D-39	Homo sapiens	147-150
2062811-2	1991	The aqueous solubility of ovine growth hormone at pH 7.4 was increased through the use of HPCD.	2-Hydroxypropyl-beta-cyclodextrin	90-94	growth hormone 1	Homo sapiens	32-46
2062811-8	1991	Aggregation of insulin was also suppressed by HPCD.	2-Hydroxypropyl-beta-cyclodextrin	46-50	insulin	Homo sapiens	15-22
33775727-3	2021	2-Hydroxypropyl beta-cyclodextrin (HP-beta-CD) is one of the promising excipients applied recently for HCF development of IgG and Ig-based therapeutics although it has been used for formulation of small synthesized chemical drugs for more than thirty years.	2-Hydroxypropyl-beta-cyclodextrin	0-33	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-45
33940723-4	2021	In this study, a DMDS-controlled release formulation was developed by encapsulating DMDS in the cavity of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	106-139	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	144-151
33775727-4	2021	This review describes essential aspects about application of HP-beta-CD as excipient in pharmaceutical formulation, including physico-chemical properties of HP-beta-CD, supply chain, regulatory, patent landscape, marketed drugs with HP-beta-CD, analytics and analytical challenges, stability and control strategies, and safety concerns.	2-Hydroxypropyl-beta-cyclodextrin	61-71	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	160-167
33236374-1	2021	OBJECTIVE: The aim of the present study was to evaluate the effect of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical setup.	2-Hydroxypropyl-beta-cyclodextrin	70-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	106-113
33971083-7	2021	Results showed that the inclusion of hydroxypropyl-beta-cyclodextrin with butylphthalide significantly improved the pharmacokinetic behavior of free body HP-beta-CD and NBP in vivo.	2-Hydroxypropyl-beta-cyclodextrin	37-68	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	157-164
33806952-5	2021	The results showed that hydroxypropyl-beta-cyclodextrin (HP-beta-CD), rather than solid carriers commonly used in solidification of traditional Pickering emulsions, was suitable for the solid NSSPE to retain the original appearance and size of emulsion droplets after reconstitution.	2-Hydroxypropyl-beta-cyclodextrin	24-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	60-67
32890578-0	2020	Delineation of metabolic responses of Npc1-/-nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	127-160	NPC intracellular cholesterol transporter 1	Mus musculus	38-42
32890578-0	2020	Delineation of metabolic responses of Npc1-/-nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	127-160	sterol O-acyltransferase 2	Mus musculus	97-102
32890578-4	2020	To date, the most effective agent for promoting release of entrapped UC in nearly all organs of NPC1-deficient mice and cats is 2-hydroxypropyl-beta-cyclodextrin (2HPbetaCD).	2-Hydroxypropyl-beta-cyclodextrin	128-161	NPC intracellular cholesterol transporter 1	Mus musculus	96-100
32890578-4	2020	To date, the most effective agent for promoting release of entrapped UC in nearly all organs of NPC1-deficient mice and cats is 2-hydroxypropyl-beta-cyclodextrin (2HPbetaCD).	2-Hydroxypropyl-beta-cyclodextrin	163-172	NPC intracellular cholesterol transporter 1	Mus musculus	96-100
32890578-8	2020	These findings have implications for systemic 2HPbetaCD treatment in NPC1 patients in view of the purportedly low levels of SOAT2 activity in human liver.	2-Hydroxypropyl-beta-cyclodextrin	46-55	NPC intracellular cholesterol transporter 1	Homo sapiens	69-73
34954480-2	2022	The findings revealed that estradiol enclosed into the cavity of beta-CD and HP-beta-CD and produced the estradiol-beta-CD and estradiol-HP-beta-CD complexes with the stoichiometry of 1:1.	2-Hydroxypropyl-beta-cyclodextrin	77-87	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	65-72
23737847-0	2013	Inclusion Complex of Zerumbone with Hydroxypropyl- beta -Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio.	2-Hydroxypropyl-beta-cyclodextrin	36-69	caspase 8	Homo sapiens	128-137
23737847-0	2013	Inclusion Complex of Zerumbone with Hydroxypropyl- beta -Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio.	2-Hydroxypropyl-beta-cyclodextrin	36-69	BH3 interacting domain death agonist	Homo sapiens	138-141
23737847-0	2013	Inclusion Complex of Zerumbone with Hydroxypropyl- beta -Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio.	2-Hydroxypropyl-beta-cyclodextrin	36-69	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
34954480-6	2022	And, it is also observed that the phenyl moiety in estradiol is almost parallel to the central axis of beta-CD and HP-beta-CD, and the phenyl moiety was located on wider rim of beta-CD and HP-beta-CD.	2-Hydroxypropyl-beta-cyclodextrin	115-125	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	177-184
34954480-2	2022	The findings revealed that estradiol enclosed into the cavity of beta-CD and HP-beta-CD and produced the estradiol-beta-CD and estradiol-HP-beta-CD complexes with the stoichiometry of 1:1.	2-Hydroxypropyl-beta-cyclodextrin	77-87	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	115-122
34954480-6	2022	And, it is also observed that the phenyl moiety in estradiol is almost parallel to the central axis of beta-CD and HP-beta-CD, and the phenyl moiety was located on wider rim of beta-CD and HP-beta-CD.	2-Hydroxypropyl-beta-cyclodextrin	189-199	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	103-110
34954480-2	2022	The findings revealed that estradiol enclosed into the cavity of beta-CD and HP-beta-CD and produced the estradiol-beta-CD and estradiol-HP-beta-CD complexes with the stoichiometry of 1:1.	2-Hydroxypropyl-beta-cyclodextrin	77-87	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	140-147
34954480-5	2022	Moreover, it was confirmed from the results of molecular modeling that estradiol inserted into the hydrophobic cavity of beta-CD and HP-beta-CD and form a stable estradiol-CD complexes.	2-Hydroxypropyl-beta-cyclodextrin	133-143	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	121-128
34333358-5	2021	METHODS: Hydroxy propyl-beta-cyclodextrin(HP-beta-CD) was used to formulate readily soluble ivermectin lyophilized powder.	2-Hydroxypropyl-beta-cyclodextrin	9-41	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	45-52
34819339-9	2022	Repeated administration of HPbetaCD also preserved NeuN immunoreactivity in the striatum and thalamus and c-Fos immunoreactivity in hippocampal regions.	2-Hydroxypropyl-beta-cyclodextrin	27-35	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	51-55
34819339-9	2022	Repeated administration of HPbetaCD also preserved NeuN immunoreactivity in the striatum and thalamus and c-Fos immunoreactivity in hippocampal regions.	2-Hydroxypropyl-beta-cyclodextrin	27-35	FBJ osteosarcoma oncogene	Mus musculus	106-111
34364573-1	2021	The purpose of this study was to use hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen.	2-Hydroxypropyl-beta-cyclodextrin	37-68	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	73-80
34771576-1	2021	2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) is widely used as an enabling excipient in pharmaceutical formulations.	2-Hydroxypropyl-beta-cyclodextrin	0-33	cytochrome b-245, beta polypeptide	Mus musculus	43-46
34592985-9	2021	Cholesterol storage, mitochondrial dysfunction, and axonal trafficking defects can be ameliorated by treatment with 2-hydroxypropyl-beta-cyclodextrin, a drug that has shown efficacy in NPC1 preclinical models and in a phase 1/2a trial.	2-Hydroxypropyl-beta-cyclodextrin	116-149	NPC intracellular cholesterol transporter 1	Homo sapiens	185-189
34718092-2	2021	A novel gastroretentive drug delivery system was developed by preparing the hydroxypropyl-beta-cyclodextrin (HP-beta-CD) inclusion complex incorporated into chitosan nanoparticles (V-CD/NPs), to improve the bioavailability of VEO and its protective effect on gastric mucosa.	2-Hydroxypropyl-beta-cyclodextrin	76-107	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	112-119
34296265-4	2021	This study analyzed RNA-Seq data from 42 NPC1 patient-derived, primary fibroblast cell lines to determine transcriptional changes induced by treatment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a compound currently under investigation in clinical trials.	2-Hydroxypropyl-beta-cyclodextrin	191-199	NPC intracellular cholesterol transporter 1	Homo sapiens	41-45
34296265-8	2021	Overall, this large NPC1 patient-derived dataset provides a comprehensive foundation for understanding the genomic response to HPbetaCD treatment.	2-Hydroxypropyl-beta-cyclodextrin	127-135	NPC intracellular cholesterol transporter 1	Homo sapiens	20-24
34364701-1	2021	The purpose of this study is to find that a small amount of 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can produce a parachute effect on indomethacin (INM).	2-Hydroxypropyl-beta-cyclodextrin	60-93	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	98-105
34356363-3	2021	In this work, a grape cane pilot-plant extract (GCPPE) was encapsulated in hydroxypropyl beta-cyclodextrin (HP-beta-CD) by a spray-drying technique and the formation of an inclusion complex was confirmed by microscopy and infrared spectroscopy.	2-Hydroxypropyl-beta-cyclodextrin	75-106	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	111-118
34436503-2	2021	Our previous study demonstrated that 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) attenuated EMT by blocking the transforming growth factor (TGF)-beta/Smad signaling pathway and activating ER stress in MDA-MB-231 cells.	2-Hydroxypropyl-beta-cyclodextrin	37-70	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	75-82
34436503-2	2021	Our previous study demonstrated that 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) attenuated EMT by blocking the transforming growth factor (TGF)-beta/Smad signaling pathway and activating ER stress in MDA-MB-231 cells.	2-Hydroxypropyl-beta-cyclodextrin	37-70	transforming growth factor alpha	Homo sapiens	115-152
34436503-8	2021	However, HP-beta-CD is proposed to deplete membrane cholesterol at low concentrations and concurrently inhibit ER stress and induce EMT by promoting the TGF-beta signaling pathways.	2-Hydroxypropyl-beta-cyclodextrin	9-19	transforming growth factor alpha	Homo sapiens	153-161
34480898-9	2021	Treating HUVECs with a cholesterol chelator hydroxypropyl-beta-cyclodextrin demonstrated that depletion of cholesterol was sufficient to rescue HUVECs from TNFalpha-induced apoptosis, even in the presence of FAC.	2-Hydroxypropyl-beta-cyclodextrin	44-75	tumor necrosis factor	Homo sapiens	156-164
34175669-8	2021	Hepatocytes from Npc1+/+ mice treated with U18666A exhibited increased mchol accumulation, STARD1 upregulation and decreased ACDase expression, effects that were reversed by cholesterol extraction with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	202-235	NPC intracellular cholesterol transporter 1	Mus musculus	17-21
34175669-8	2021	Hepatocytes from Npc1+/+ mice treated with U18666A exhibited increased mchol accumulation, STARD1 upregulation and decreased ACDase expression, effects that were reversed by cholesterol extraction with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	202-235	steroidogenic acute regulatory protein	Mus musculus	91-97
34175669-8	2021	Hepatocytes from Npc1+/+ mice treated with U18666A exhibited increased mchol accumulation, STARD1 upregulation and decreased ACDase expression, effects that were reversed by cholesterol extraction with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	202-235	N-acylsphingosine amidohydrolase 1	Mus musculus	125-131
34468866-3	2021	Here, we have studied the interaction between 2-hydroxypropyl beta-CD (HPbetaCD) and three water-soluble drugs, namely naloxone (NX), oxycodone (OC), and tramadol (TR), by isothermal titration calorimetry (ITC) combined with molecular modeling in view of the potential impact on drug release.	2-Hydroxypropyl-beta-cyclodextrin	71-79	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	62-69
34468866-3	2021	Here, we have studied the interaction between 2-hydroxypropyl beta-CD (HPbetaCD) and three water-soluble drugs, namely naloxone (NX), oxycodone (OC), and tramadol (TR), by isothermal titration calorimetry (ITC) combined with molecular modeling in view of the potential impact on drug release.	2-Hydroxypropyl-beta-cyclodextrin	71-79	coagulation factor II thrombin receptor	Homo sapiens	164-166
34301017-1	2021	In this study, hydroxypropyl-beta-cyclodextrin (HP-beta-CD) particles were produced using supercritical assisted atomization (SAA) with carbon dioxide as the spraying medium or co-solute and aqueous ethanol solution as the solvent.	2-Hydroxypropyl-beta-cyclodextrin	15-46	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	51-58
34150357-2	2021	The investigational use of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in the treatment of NPC has shown promising results in improving life expectancy and reducing neurological damage in this patient population.	2-Hydroxypropyl-beta-cyclodextrin	27-60	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	65-72
34168432-1	2021	Background: The aim of this work was to develop a novel and feasible modification strategy by utilizing the supramolecular effect of 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) for enhancing the biological transport efficiency of paclitaxel (PTX)-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles.	2-Hydroxypropyl-beta-cyclodextrin	133-166	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	173-180
34126897-4	2022	OBJECTIVE: To analyze (Autodock Vina software and CycloMolder platform) the formation of inclusion complexes between ABZ, beta-cyclodextrin (beta-CD) and its derivatives, Methyl-beta-cyclodextrin (M-beta-CD) and Hydroxypropyl-beta-cyclodextrin (HP-beta-CD), through in vitro and in silico studies.	2-Hydroxypropyl-beta-cyclodextrin	212-243	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	141-148
34126897-4	2022	OBJECTIVE: To analyze (Autodock Vina software and CycloMolder platform) the formation of inclusion complexes between ABZ, beta-cyclodextrin (beta-CD) and its derivatives, Methyl-beta-cyclodextrin (M-beta-CD) and Hydroxypropyl-beta-cyclodextrin (HP-beta-CD), through in vitro and in silico studies.	2-Hydroxypropyl-beta-cyclodextrin	212-243	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	248-255
35490765-1	2022	The current work aimed to enhance the oral bioavailability of water-insoluble drug Artemisinin (ART) by the inclusion of ART with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and then loaded with porous starch (PS).	2-Hydroxypropyl-beta-cyclodextrin	130-161	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	166-173
35158266-0	2022	Investigation on detoxication effects of 2-hydroxypropyl-beta-cyclodextrin over two halogenated aromatic DBPs 2,4,6-trichlorophenol and 2,4,6-tribromophenol binding with human serum albumin.	2-Hydroxypropyl-beta-cyclodextrin	41-74	albumin	Homo sapiens	176-189
35158266-2	2022	Herein, by using in vitro (fluorescence quenching, UV absorbance, circular dichroism) and in silico (molecular docking) method, binding interactions of two halophenolic DBPs (2,4,6-trichlorophenol (TCP) and 2,4,6-tribromophenol (TBP)) with human serum albumin (HSA) and the influence of hydroxypropyl-beta-cyclodextrin (HPCD) on the interactions were investigated.	2-Hydroxypropyl-beta-cyclodextrin	287-318	albumin	Homo sapiens	252-259
35158266-2	2022	Herein, by using in vitro (fluorescence quenching, UV absorbance, circular dichroism) and in silico (molecular docking) method, binding interactions of two halophenolic DBPs (2,4,6-trichlorophenol (TCP) and 2,4,6-tribromophenol (TBP)) with human serum albumin (HSA) and the influence of hydroxypropyl-beta-cyclodextrin (HPCD) on the interactions were investigated.	2-Hydroxypropyl-beta-cyclodextrin	320-324	albumin	Homo sapiens	252-259
35287906-1	2022	The aim of this study was to investigate the effects of beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on the physical and anti-staling properties of corn starch (CS).	2-Hydroxypropyl-beta-cyclodextrin	88-119	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	124-131
35337497-1	2022	In this work, the solution blow spinning (SBS) technique was used to rapidly fabricate the thymol (THY)/2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) inclusion complexes loaded chitosan (CS)/polycaprolactone (PCL) nanofibrous films for fruit preservation and packaging.	2-Hydroxypropyl-beta-cyclodextrin	104-137	citrate synthase	Homo sapiens	186-188
35337497-1	2022	In this work, the solution blow spinning (SBS) technique was used to rapidly fabricate the thymol (THY)/2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) inclusion complexes loaded chitosan (CS)/polycaprolactone (PCL) nanofibrous films for fruit preservation and packaging.	2-Hydroxypropyl-beta-cyclodextrin	139-147	citrate synthase	Homo sapiens	186-188
35337497-4	2022	FTIR and thermal analysis showed that the thermal stability was also improved due to the formation of hydrogen bonds between THY/HPbetaCD inclusion complexes and CS/PCL nanofibers.	2-Hydroxypropyl-beta-cyclodextrin	129-137	citrate synthase	Homo sapiens	162-164
35630687-3	2022	In this study, the inclusion complex of RBG with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was prepared using the co-evaporation method, and the molar ratio of RBG to CD was determined to be approximately 1:2 by continuous variation plot for both CDs.	2-Hydroxypropyl-beta-cyclodextrin	81-114	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	119-126
35631996-1	2022	In this study, the enhanced solubilization performance of a poorly soluble drug, beclomethasone dipropionate (BDP), was investigated using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and ethanol.	2-Hydroxypropyl-beta-cyclodextrin	139-170	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	175-182
35506864-4	2022	Herein, we have fabricated lactose-appended hydroxypropyl-beta-cyclodextrin (Lac-HPbetaCD) and evaluated its lowering effects on cholesterol accumulation in NPC model mice.	2-Hydroxypropyl-beta-cyclodextrin	44-75	lactase	Mus musculus	77-80
35287906-1	2022	The aim of this study was to investigate the effects of beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on the physical and anti-staling properties of corn starch (CS).	2-Hydroxypropyl-beta-cyclodextrin	88-119	citrate synthase	Homo sapiens	193-195
35458617-2	2022	Its formulation with the non-toxic 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) could improve its pharmacological profile.	2-Hydroxypropyl-beta-cyclodextrin	35-68	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	75-82
35227839-3	2022	Therefore in this study inclusion complexes of Q and R with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were formulated to improve the aqueous solubility, antiproliferative efficacy and also antioxidant activity of the flavonoids.	2-Hydroxypropyl-beta-cyclodextrin	60-91	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	96-103
35629772-3	2022	The sensors were based on the use of 4"-nitrobenzo-15-crown-5 (ionophore I), dibenzo-18-crown-6 (ionophore II), and 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) (ionophore III) as neutral carriers within a plasticized PVC matrix.	2-Hydroxypropyl-beta-cyclodextrin	116-149	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	156-163
35424977-1	2022	Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1.	2-Hydroxypropyl-beta-cyclodextrin	105-138	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
35166277-2	2022	For resolving this issue, hydroxypropyl-beta-cyclodextrin-carbon black (HP-beta-CD-CB) nanohybrid that possesses the collaborative advantages of CB (e.g., excellent electrical properties, large surface area) and HP-beta-CD (e.g., high molecule recognition and preconcentration capability) was synthesized in this study via a simple process and then utilized as a novel electrode material to electrochemically detect BZC.	2-Hydroxypropyl-beta-cyclodextrin	26-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	215-222
35424977-1	2022	Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1.	2-Hydroxypropyl-beta-cyclodextrin	223-233	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
35424977-3	2022	Moreover, the complexation behaviors of HP-beta-CD with benzaldehyde and intermediates were studied by UV-vis and 2D-ROESY NMR spectroscopies to reveal the plausible mechanisms of the reactions, and HP-beta-CD did not act as a simple phase transfer agent.	2-Hydroxypropyl-beta-cyclodextrin	199-209	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	43-50
35424918-1	2022	A hydroxypropyl-beta-cyclodextrin (HP-beta-CD) imprinted coating based on polyhedral oligomeric silsesquioxane (POSS) for open tubular electrochromatography was prepared.	2-Hydroxypropyl-beta-cyclodextrin	2-33	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-45
35311602-1	2022	AIM: To prepare ecdysterone(ES)/hydroxypropyl-beta-cyclodextrin(HP-beta-CD) inclusion complex, thus improving the water solubility and bioavailability of ES.	2-Hydroxypropyl-beta-cyclodextrin	32-63	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	67-74
35118566-9	2022	Also, the micelles with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as lyophilization protectants had minimal variation in particle size.	2-Hydroxypropyl-beta-cyclodextrin	24-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	60-67
35175724-4	2022	In this study, we fabricated a novel thin-film composite nanofiltration membrane composed of (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD) as the chiral selector for the enantiomeric separation of racemic 1-phenylethanol chiral compounds in organic solvents.	2-Hydroxypropyl-beta-cyclodextrin	93-128	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	133-140
34653273-3	2022	In the present study, we have designed and evaluated Hydroxypropyl-beta-cyclodextrin (HP-beta-CD),) based conventional formulations of TAA (aqueous suspensions) with different dose strengths to identify the dose strength required for achieving the effective concentrations in vitreous humor following pre-corneal administration of the formulations.	2-Hydroxypropyl-beta-cyclodextrin	53-84	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	89-96
35095535-2	2021	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD) is a cyclic oligosaccharide derivative that is being developed to treat NPC1.	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Mus musculus	117-121
35095535-2	2021	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD) is a cyclic oligosaccharide derivative that is being developed to treat NPC1.	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Mus musculus	117-121
35095535-6	2021	However, cotreatment with metformin reduced inflammatory response and inhibited the proinflammatory cytokine release in the brain, liver and spleen of HPbetaCD-treated Npc1 -/- mice.	2-Hydroxypropyl-beta-cyclodextrin	151-159	NPC intracellular cholesterol transporter 1	Mus musculus	168-172
35095535-8	2021	In conclusion, our results demonstrate that metformin does not show beneficial effects on body weight or survival time but reduced the inflammatory response in a mouse model of NPC1 when combined with HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	201-209	NPC intracellular cholesterol transporter 1	Mus musculus	177-181
35370195-4	2022	2-Hydroxypropyl-beta-CD (HPBCD) has activity as a cholesterol shuttle and can attenuate NPC-related manifestations in model cells and animals.	2-Hydroxypropyl-beta-cyclodextrin	25-30	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	16-23
35056780-4	2022	From the results calculated by the AutoDock program it can be predicted that insulin can make a stable complex with 5-7 molecules of hydroxypropyl-beta-cyclodextrin or sulfobutylether-beta-cyclodextrin, and by forming a complex potentially can prevent or delay the amyloid fibrillation of the insulin and increase the stability of the molecule.	2-Hydroxypropyl-beta-cyclodextrin	133-164	insulin	Homo sapiens	77-84
33919582-3	2021	The combination of piperine with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood-brain barrier.	2-Hydroxypropyl-beta-cyclodextrin	33-66	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	71-78
33838791-1	2021	In this study, we have investigated the host-guest inclusion complexes between beta-cyclodextrin (betaCD), 2-hydroxypropyl-beta-cyclodextrin (2-HPbetaCD), and mono-6-tosyl-beta-cyclodextrin (TS-betaCD) excipients and two amino acids, such as L-arginine (L-Arg) and L-lysine (L-Lys).	2-Hydroxypropyl-beta-cyclodextrin	107-140	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	146-152
33998067-9	2021	In this study, we sought to investigate the effects of the oral administration of Ang-(1-7) included in hydroxypropyl beta-cyclodextrin (HPbeta-CD) in preventing and treating muscle damage following downhill running.	2-Hydroxypropyl-beta-cyclodextrin	137-146	angiogenin	Rattus norvegicus	82-90
3255320-6	1988	Complexation of T-CDS1 with 2-hydroxypropyl-beta-cyclodextrin allowed a lowering of the effective LH-suppressing dose of T-CDS1 from 25 mg/kg to 10 mg/kg, presumably by increasing the solubility of T-CDS1 in the blood.	2-Hydroxypropyl-beta-cyclodextrin	28-61	CDP-diacylglycerol synthase 1	Homo sapiens	123-127
3255320-6	1988	Complexation of T-CDS1 with 2-hydroxypropyl-beta-cyclodextrin allowed a lowering of the effective LH-suppressing dose of T-CDS1 from 25 mg/kg to 10 mg/kg, presumably by increasing the solubility of T-CDS1 in the blood.	2-Hydroxypropyl-beta-cyclodextrin	28-61	CDP-diacylglycerol synthase 1	Homo sapiens	123-127
3255320-7	1988	These findings suggest that testosterone can be effectively delivered to the central nervous system (CNS) with minimal peripheral effect, and the delivery of T-CDS1 to the CNS can be improved via complexation with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	214-247	CDP-diacylglycerol synthase 1	Homo sapiens	160-164
33999634-4	2021	Here, a computational approach is proposed to clarify the role of beta-cyclodextrin (betaCD) and 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) against granulocyte colony-stimulating (GCSF) factor denaturation at the air-water and ice-water interfaces, and also in bulk water at 300 or 260 K. Both traditional molecular dynamics (MD) simulations and enhanced sampling techniques (metadynamics, MetaD) are used to shed light on the underlying molecular mechanisms.	2-Hydroxypropyl-beta-cyclodextrin	97-130	colony stimulating factor 3	Homo sapiens	182-186
33999634-4	2021	Here, a computational approach is proposed to clarify the role of beta-cyclodextrin (betaCD) and 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) against granulocyte colony-stimulating (GCSF) factor denaturation at the air-water and ice-water interfaces, and also in bulk water at 300 or 260 K. Both traditional molecular dynamics (MD) simulations and enhanced sampling techniques (metadynamics, MetaD) are used to shed light on the underlying molecular mechanisms.	2-Hydroxypropyl-beta-cyclodextrin	132-140	colony stimulating factor 3	Homo sapiens	182-186
33944678-2	2021	This study describes a simple method to prepare modified aerobic granular sludge (AGS) by hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	90-121	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	126-133
33745428-6	2021	RESULTS: Hydroxypropyl beta cyclodextrin (HP-beta-CD) better solubilized AMB than both alpha-CD and beta-CD e.g, the concentration of water-soluble AMB/HP-beta-CD IC could reach 465 microg/mL.	2-Hydroxypropyl-beta-cyclodextrin	9-40	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	45-52
33860449-3	2022	To improve the effect of OM, a ternary OM solid dispersion consisting of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and hydroxypropyl methylcellulose (HPMC) was prepared by mechanochemical method.	2-Hydroxypropyl-beta-cyclodextrin	73-104	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	109-116
33782944-1	2021	A cyclic heptasaccharide, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), is a cholesterol solubilizer that is being developed to treat NPC, but its ototoxicity and pulmonary toxicity remain important issues.	2-Hydroxypropyl-beta-cyclodextrin	26-59	adrenocortical dysplasia	Mus musculus	64-71
33466390-0	2021	Intracerebroventricular Treatment with 2-Hydroxypropyl-beta-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice.	2-Hydroxypropyl-beta-cyclodextrin	39-72	glycoprotein (transmembrane) nmb	Mus musculus	106-151
33253428-1	2021	The complexation of ester betulin derivatives with (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD) was studied by mobility shift affinity capillary electrophoresis.	2-Hydroxypropyl-beta-cyclodextrin	51-86	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	91-98
33352504-1	2021	2-(3-Methylphenyl)propanic acid and 2-(4-methylphenyl)propanoic acid were successfully enantioseparated by countercurrent chromatography using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as a chiral selector.	2-Hydroxypropyl-beta-cyclodextrin	143-174	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	179-186
32860997-4	2021	Thus, this study aims to use (-)-borneol as a monoterpene model to prepare inclusion complexes between beta-CD and hydroxypropyl-beta-CD (HP-beta-CD) through different ways and characterize them in order to choose the best inclusion method to improve physicochemical properties of monoterpenes.	2-Hydroxypropyl-beta-cyclodextrin	115-136	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	103-110
33668491-2	2021	This work aimed at developing an effective method that can be utilized for the determination of I (S), I (R), and II (S) and II (R) enantiomers of (I) and (II) compounds through the use of a dual chiral-achiral selector complex consisting of hydroxypropyl-beta-cyclodextrin and 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin system by applying capillary electrophoresis.	2-Hydroxypropyl-beta-cyclodextrin	242-273	secretoglobin family 1D member 4	Homo sapiens	114-159
33183638-0	2021	Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin for oral insulin delivery.	2-Hydroxypropyl-beta-cyclodextrin	69-100	insulin	Homo sapiens	110-117
33183638-4	2021	In this study, a novel N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin (NAC-HP-beta-CD-Arg) was successfully synthesized and characterized.	2-Hydroxypropyl-beta-cyclodextrin	65-96	synuclein alpha	Homo sapiens	98-101
33183638-4	2021	In this study, a novel N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin (NAC-HP-beta-CD-Arg) was successfully synthesized and characterized.	2-Hydroxypropyl-beta-cyclodextrin	65-96	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	105-112
33466390-0	2021	Intracerebroventricular Treatment with 2-Hydroxypropyl-beta-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice.	2-Hydroxypropyl-beta-cyclodextrin	39-72	glycoprotein (transmembrane) nmb	Mus musculus	153-158
33466390-3	2021	In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B (GPNMB) to act as a biomarker reflecting the therapeutic effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in an NPC mouse model.	2-Hydroxypropyl-beta-cyclodextrin	161-194	glycoprotein (transmembrane) nmb	Mus musculus	48-93
33466390-3	2021	In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B (GPNMB) to act as a biomarker reflecting the therapeutic effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in an NPC mouse model.	2-Hydroxypropyl-beta-cyclodextrin	161-194	adrenocortical dysplasia	Mus musculus	199-206
33065226-4	2021	In this study, DSF was embedded in hydroxypropyl-beta-cyclodextrin (HP-beta-CD) to prepare a DSF inclusion complex with the enhanced solubility, anti-GBM activity and high safety in vitro.	2-Hydroxypropyl-beta-cyclodextrin	35-66	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	71-78
33113137-8	2021	To better illustrate the technique"s rationale, the interaction between 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and the antihypertensive drug losartan is investigated.	2-Hydroxypropyl-beta-cyclodextrin	72-105	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	110-117
32798987-4	2020	In this way, to improve the pharmaceutical properties, the HK was complexed in hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and its oral bioavailability and antitumor effects were evaluated.	2-Hydroxypropyl-beta-cyclodextrin	79-110	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	115-122
33157211-2	2020	In this study, we present a gentle drying technology for monoclonal antibodies, applying the water soluble 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as matrix, to prepare a solid reconstitution dosage form.	2-Hydroxypropyl-beta-cyclodextrin	107-140	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	145-152
33505938-1	2020	The objective of this study was to synthesize and characterize inclusion complexes of phenolic acids with hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	106-137	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	142-149
33505939-1	2020	The objective of this study was to investigate characterization of inclusion complexes of flavonoids with hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	106-137	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	142-149
32804273-3	2020	By optimizing the ratio of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and PS to 1:1 (w/w), most products crystallized during the biotransformation process.	2-Hydroxypropyl-beta-cyclodextrin	27-58	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	63-70
32090640-3	2020	Meanwhile, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier.	2-Hydroxypropyl-beta-cyclodextrin	11-44	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	49-56
33171970-0	2020	Complexation with Random Methyl-beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin Promotes Chrysin Effect and Potential for Liver Fibrosis Therapy.	2-Hydroxypropyl-beta-cyclodextrin	54-89	chromate resistance; sulfate transport	Homo sapiens	99-106
33222104-6	2020	Molecular dynamics (MD) simulation revealed lycopene molecule was wrapped within the aggregates of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and PEG 6000 through extensive hydrogen bond interactions, which was experimentally validated by DSC, XRD, and FTIR spectrum analysis.	2-Hydroxypropyl-beta-cyclodextrin	99-130	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
33262593-2	2020	We developed a poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) surface modified respectively with 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD), chitosan oligosaccharide and trehalose.	2-Hydroxypropyl-beta-cyclodextrin	105-138	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	145-152
33171970-3	2020	The aim of this study was to investigate the biocompatibility of CHR complexes with two cyclodextrins (CDs)-(2-hydroxypropyl)-beta-cyclodextrin (HPBCD) and random methyl-beta-cyclodextrin (RAMEB), and their potential to induce anti-inflammatory, antioxidant and anti-fibrotic effects.	2-Hydroxypropyl-beta-cyclodextrin	108-143	chromate resistance; sulfate transport	Homo sapiens	65-68
33171970-3	2020	The aim of this study was to investigate the biocompatibility of CHR complexes with two cyclodextrins (CDs)-(2-hydroxypropyl)-beta-cyclodextrin (HPBCD) and random methyl-beta-cyclodextrin (RAMEB), and their potential to induce anti-inflammatory, antioxidant and anti-fibrotic effects.	2-Hydroxypropyl-beta-cyclodextrin	145-150	chromate resistance; sulfate transport	Homo sapiens	65-68
33158197-5	2020	Among many CMPAs, successful TER enantioresolution was achieved using hydroxypropyl beta-cyclodextrin (HP-beta-CD) added to the mobile phase as 5.4 mM HP-beta-CD in 52.25 mM ammonium acetate.	2-Hydroxypropyl-beta-cyclodextrin	70-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	106-113
33158197-5	2020	Among many CMPAs, successful TER enantioresolution was achieved using hydroxypropyl beta-cyclodextrin (HP-beta-CD) added to the mobile phase as 5.4 mM HP-beta-CD in 52.25 mM ammonium acetate.	2-Hydroxypropyl-beta-cyclodextrin	70-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	154-161
33023196-3	2020	The aim of this study was to improve the solubility of alpha-M through complex formation with 2-hydroxypropyl-beta-cyclodextrin (alpha-M/HP-beta-CD CX) and to evaluate the healing activity of the complex.	2-Hydroxypropyl-beta-cyclodextrin	94-127	adrenomedullin	Mus musculus	55-62
32236723-9	2020	DeltaZ of hydroxypropyl-beta-cyclodextrin:TiF4 72 h was higher than negative control, hydroxypropyl-beta-cyclodextrin, gamma-cyclodextrin, gamma-cyclodextrin:TiF4 1 2 h, gamma-cyclodextrin:TiF4 72 h, and NaF (p < 0.05) and similar to TiF4 and hydroxypropyl-beta-cyclodextrin:TiF4 12 h (p > 0.05).	2-Hydroxypropyl-beta-cyclodextrin	10-41	C-X-C motif chemokine ligand 8	Homo sapiens	204-207
33023196-3	2020	The aim of this study was to improve the solubility of alpha-M through complex formation with 2-hydroxypropyl-beta-cyclodextrin (alpha-M/HP-beta-CD CX) and to evaluate the healing activity of the complex.	2-Hydroxypropyl-beta-cyclodextrin	94-127	adrenomedullin	Mus musculus	129-136
32607920-1	2020	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Rattus norvegicus	158-173
32743855-1	2020	The inclusion interaction between hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and 21 2-aryl carboxylic acids was investigated by UV (ultraviolet) spectrophotometer.	2-Hydroxypropyl-beta-cyclodextrin	34-65	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	70-77
32956992-1	2020	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by preferentially destroying outer hair cells.	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Rattus norvegicus	83-98
32956992-1	2020	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by preferentially destroying outer hair cells.	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Rattus norvegicus	100-104
32956992-1	2020	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by preferentially destroying outer hair cells.	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Rattus norvegicus	83-98
32956992-1	2020	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by preferentially destroying outer hair cells.	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Rattus norvegicus	100-104
32956992-8	2020	HPbetaCD-mediated apoptosis in P3 cultures was most-strongly initiated by activation of the extrinsic caspase-8 cell death pathway in cochlear and vestibular hair cells and neurons followed by activation of executioner caspase-3.	2-Hydroxypropyl-beta-cyclodextrin	0-8	caspase 8	Rattus norvegicus	102-111
32956992-8	2020	HPbetaCD-mediated apoptosis in P3 cultures was most-strongly initiated by activation of the extrinsic caspase-8 cell death pathway in cochlear and vestibular hair cells and neurons followed by activation of executioner caspase-3.	2-Hydroxypropyl-beta-cyclodextrin	0-8	caspase 3	Rattus norvegicus	219-228
32607920-1	2020	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Rattus norvegicus	175-179
32607920-1	2020	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Rattus norvegicus	158-173
32607920-1	2020	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Rattus norvegicus	175-179
32191845-3	2020	The results showed that the PTS:HPbetaCD complex increased the content of reduced glutathione and the activity of glutathione-S-transferase and glutaredoxin in the right ventricle (RV) of MCT-treated rats in a dose-dependent manner.	2-Hydroxypropyl-beta-cyclodextrin	32-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	114-139
32191845-3	2020	The results showed that the PTS:HPbetaCD complex increased the content of reduced glutathione and the activity of glutathione-S-transferase and glutaredoxin in the right ventricle (RV) of MCT-treated rats in a dose-dependent manner.	2-Hydroxypropyl-beta-cyclodextrin	32-40	glutaredoxin	Rattus norvegicus	144-156
32705246-0	2020	2-Hydroxypropyl-beta-cyclodextrin blocks autophagy flux and triggers caspase-8-mediated apoptotic cascades in HepG2 cells.	2-Hydroxypropyl-beta-cyclodextrin	0-33	caspase 8	Homo sapiens	69-78
32705246-4	2020	It was found that a high dose (20 mM) of HPbetaCD treatment significantly inhibited the AKT/mTOR pathway and disrupted infusion of autophagosomes and lysosomes, which rapidly led to massive autophagosome accumulation in HepG2 cells.	2-Hydroxypropyl-beta-cyclodextrin	41-49	AKT serine/threonine kinase 1	Homo sapiens	88-91
32705246-4	2020	It was found that a high dose (20 mM) of HPbetaCD treatment significantly inhibited the AKT/mTOR pathway and disrupted infusion of autophagosomes and lysosomes, which rapidly led to massive autophagosome accumulation in HepG2 cells.	2-Hydroxypropyl-beta-cyclodextrin	41-49	mechanistic target of rapamycin kinase	Homo sapiens	92-96
32691965-3	2020	To circumvent this problem, a drug delivery system with 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) was explored.	2-Hydroxypropyl-beta-cyclodextrin	56-89	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	96-103
32534161-4	2020	A tetracycline-type antibiotic with low water solubility (doxycycline (DOX)) was used with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as solubilizer.	2-Hydroxypropyl-beta-cyclodextrin	91-124	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	129-136
32785200-5	2020	First, CAP solubility increased up to 20 times with hydroxypropyl-beta-cyclodextrin (HP-beta-CD), as shown by the phase solubility study.	2-Hydroxypropyl-beta-cyclodextrin	52-83	adrenocortical dysplasia	Mus musculus	88-95
32872207-4	2020	One possible way to overcome all these problems could be the addition of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) to the GG-Gly formulation as a drug-precipitation inhibitor.	2-Hydroxypropyl-beta-cyclodextrin	73-104	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	109-116
32354235-12	2020	Furthermore, we demonstrated that 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a clinical agent used to enhance the solubility of drugs, activates TFEB and inhibits AAA formation and progression in mice.	2-Hydroxypropyl-beta-cyclodextrin	34-67	transcription factor EB	Mus musculus	148-152
32354235-12	2020	Furthermore, we demonstrated that 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a clinical agent used to enhance the solubility of drugs, activates TFEB and inhibits AAA formation and progression in mice.	2-Hydroxypropyl-beta-cyclodextrin	69-77	transcription factor EB	Mus musculus	148-152
32354235-13	2020	Finally, we found that HPbetaCD inhibits AAA in a VSMC TFEB-dependent manner in mouse models.	2-Hydroxypropyl-beta-cyclodextrin	23-31	transcription factor EB	Mus musculus	55-59
32354235-15	2020	TFEB activation by HPbetaCD may be a promising therapeutic strategy for the prevention and treatment of AAA.	2-Hydroxypropyl-beta-cyclodextrin	19-27	transcription factor EB	Mus musculus	0-4
32698250-0	2021	2-Hydroxypropyl-beta-cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production.	2-Hydroxypropyl-beta-cyclodextrin	0-33	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	79-86
32698250-0	2021	2-Hydroxypropyl-beta-cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production.	2-Hydroxypropyl-beta-cyclodextrin	0-33	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	90-97
32698250-9	2021	KEY RESULTS: In both wild type and Cyp27a1-/- Cyp46a1-/- mice, HPCD crossed the blood-retinal barrier when delivered i.p.	2-Hydroxypropyl-beta-cyclodextrin	63-67	cytochrome P450, family 27, subfamily a, polypeptide 1	Mus musculus	35-42
32698250-9	2021	KEY RESULTS: In both wild type and Cyp27a1-/- Cyp46a1-/- mice, HPCD crossed the blood-retinal barrier when delivered i.p.	2-Hydroxypropyl-beta-cyclodextrin	63-67	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	46-53
32390840-7	2020	To address this issue, hydroxypropyl-beta-cyclodextrin (HP-beta-CD) complexes of the compounds were synthesized by the saturated aqueous method.	2-Hydroxypropyl-beta-cyclodextrin	23-54	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	59-66
32518977-2	2020	One column was fabricated by concurrently using glycidyl methacrylate-bonded hydroxypropyl beta-cyclodextrin (GMA-HP-beta-CD), sodium 3-mercaptopropanesulphonate, and alkoxysilanes in the "one-pot" process.	2-Hydroxypropyl-beta-cyclodextrin	77-108	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	117-124
32270794-4	2020	A berberine/hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) inclusion complex was first prepared to improve the solubility of berberine and loaded into a thermoresponsive hydrogel system of poloxamers.	2-Hydroxypropyl-beta-cyclodextrin	12-44	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	49-56
32346918-1	2020	Direct enantioseparation of mandelic acid by high-performance liquid chromatography (HPLC) with a reversed phase column and a mobile phase containing a small amount of hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) was studied as an efficient method for saving consumption of the CD additive.	2-Hydroxypropyl-beta-cyclodextrin	168-200	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	205-212
32606661-7	2020	Results: Complexation of SMV with hydroxypropyl beta-cyclodextrin (HP beta-CD) was superior to all other polymers as revealed by the equilibrium saturation solubility, stability constant, complexation efficiency and thermodynamic potential.	2-Hydroxypropyl-beta-cyclodextrin	34-65	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	70-77
32517880-3	2020	Here, we evaluated the effect of treatment with the inclusion compound of Ang-(1-7) in hydroxypropyl beta-cyclodextrin (HPbetaCD) given by inhalation on pulmonary remodeling in an ovalbumin (OVA)-induced chronic allergic lung inflammation.	2-Hydroxypropyl-beta-cyclodextrin	87-118	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	74-82
32517880-3	2020	Here, we evaluated the effect of treatment with the inclusion compound of Ang-(1-7) in hydroxypropyl beta-cyclodextrin (HPbetaCD) given by inhalation on pulmonary remodeling in an ovalbumin (OVA)-induced chronic allergic lung inflammation.	2-Hydroxypropyl-beta-cyclodextrin	120-128	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	74-82
32517880-3	2020	Here, we evaluated the effect of treatment with the inclusion compound of Ang-(1-7) in hydroxypropyl beta-cyclodextrin (HPbetaCD) given by inhalation on pulmonary remodeling in an ovalbumin (OVA)-induced chronic allergic lung inflammation.	2-Hydroxypropyl-beta-cyclodextrin	120-128	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	180-189
32517880-5	2020	After the 2nd week of challenge, mice were treated with Ang-(1-7) by inhalation (4.5 mug of Ang-(1-7) included in 6.9 mug of HPbetaCD for 14 days, i.e. days 35-48).	2-Hydroxypropyl-beta-cyclodextrin	125-133	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	56-64
32210964-2	2020	We previously reported that both subcutaneous and intranasal administration of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a pharmaceutical excipient widely used to improve solubility, can act as an effective adjuvant for an influenza vaccine.	2-Hydroxypropyl-beta-cyclodextrin	79-110	adrenocortical dysplasia	Mus musculus	115-122
31839355-1	2020	The preparation of a highly efficient chiral liquid chromatography (LC) column is explored by dynamically coating a reversed-phase porous silicon pillar array column with hydroxypropyl-beta-cyclodextrin (Hp-beta-CD) as the chiral selector.	2-Hydroxypropyl-beta-cyclodextrin	171-202	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	207-214
32175596-1	2020	The purpose of this study was to prepare and characterize inclusion complexes between tea polyphenol (TP) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD), and to evaluate their antioxidant properties.	2-Hydroxypropyl-beta-cyclodextrin	110-141	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	146-153
31706864-3	2019	Considering the ability of hydroxypropyl-beta-cyclodextrin (HP-beta-CD, 100 mM) to increase the water solubility of BUD (SHP-beta-CD = 4.3 10-3 M; K1:1 = 861.11 M-1), a mucoadhesive thiolated HP-beta-CD (HP-beta-CD-SH) was synthesized and characterized by mass spectroscopy, 1H- and 13C NMR techniques.	2-Hydroxypropyl-beta-cyclodextrin	27-58	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	63-70
32394838-3	2020	The complexation of local anesthetics in 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) are able to improve pharmacological features.	2-Hydroxypropyl-beta-cyclodextrin	41-74	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	79-86
31312996-7	2020	In Npc1-/- mice given 2HPbetaCD 24 h earlier, UC levels fell, EC levels increased (although less so in mice lacking SOAT2), and cholesterol synthesis was suppressed equally in the Npc1-/-:Soat2+/+ and Npc1-/-:Soat2-/- mice.	2-Hydroxypropyl-beta-cyclodextrin	22-31	NPC intracellular cholesterol transporter 1	Mus musculus	3-7
31746388-3	2020	The present study explored the effects of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a cholesterol-depleting agent of lipid rafts, on the transforming growth factor (TGF)-beta/Smad signaling pathway and endoplasmic reticulum (ER) stress in mediating EMT in MDA-MB-231 breast cancer cells.	2-Hydroxypropyl-beta-cyclodextrin	42-73	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
31746388-3	2020	The present study explored the effects of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a cholesterol-depleting agent of lipid rafts, on the transforming growth factor (TGF)-beta/Smad signaling pathway and endoplasmic reticulum (ER) stress in mediating EMT in MDA-MB-231 breast cancer cells.	2-Hydroxypropyl-beta-cyclodextrin	42-73	transforming growth factor alpha	Homo sapiens	141-178
31746388-8	2020	Thus, HP-beta-CD can block the TGF-beta/Smad signaling pathway via diminishing the expression of TbetaRI which helps to activate ER stress and attenuate EMT in MDA-MB-231 cells, highlighting a potential target of lipid rafts for breast cancer treatment.	2-Hydroxypropyl-beta-cyclodextrin	6-16	transforming growth factor alpha	Homo sapiens	31-39
31746388-8	2020	Thus, HP-beta-CD can block the TGF-beta/Smad signaling pathway via diminishing the expression of TbetaRI which helps to activate ER stress and attenuate EMT in MDA-MB-231 cells, highlighting a potential target of lipid rafts for breast cancer treatment.	2-Hydroxypropyl-beta-cyclodextrin	6-16	transforming growth factor beta receptor 1	Homo sapiens	97-104
31999726-7	2020	Furthermore, early treatment of Npc1-/- mice with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), significantly prevented the appearance of the glycosylated LAMP1 in the cerebellum of Npc1-/- mice at 7 weeks, consistent with the prevention of neuro-inflammation in mice treated with this drug.	2-Hydroxypropyl-beta-cyclodextrin	50-83	NPC intracellular cholesterol transporter 1	Mus musculus	32-36
31999726-7	2020	Furthermore, early treatment of Npc1-/- mice with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), significantly prevented the appearance of the glycosylated LAMP1 in the cerebellum of Npc1-/- mice at 7 weeks, consistent with the prevention of neuro-inflammation in mice treated with this drug.	2-Hydroxypropyl-beta-cyclodextrin	50-83	lysosomal-associated membrane protein 1	Mus musculus	155-160
31999726-7	2020	Furthermore, early treatment of Npc1-/- mice with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), significantly prevented the appearance of the glycosylated LAMP1 in the cerebellum of Npc1-/- mice at 7 weeks, consistent with the prevention of neuro-inflammation in mice treated with this drug.	2-Hydroxypropyl-beta-cyclodextrin	50-83	NPC intracellular cholesterol transporter 1	Mus musculus	182-186
31999726-7	2020	Furthermore, early treatment of Npc1-/- mice with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), significantly prevented the appearance of the glycosylated LAMP1 in the cerebellum of Npc1-/- mice at 7 weeks, consistent with the prevention of neuro-inflammation in mice treated with this drug.	2-Hydroxypropyl-beta-cyclodextrin	85-93	NPC intracellular cholesterol transporter 1	Mus musculus	32-36
31999726-7	2020	Furthermore, early treatment of Npc1-/- mice with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), significantly prevented the appearance of the glycosylated LAMP1 in the cerebellum of Npc1-/- mice at 7 weeks, consistent with the prevention of neuro-inflammation in mice treated with this drug.	2-Hydroxypropyl-beta-cyclodextrin	85-93	lysosomal-associated membrane protein 1	Mus musculus	155-160
31999726-7	2020	Furthermore, early treatment of Npc1-/- mice with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), significantly prevented the appearance of the glycosylated LAMP1 in the cerebellum of Npc1-/- mice at 7 weeks, consistent with the prevention of neuro-inflammation in mice treated with this drug.	2-Hydroxypropyl-beta-cyclodextrin	85-93	NPC intracellular cholesterol transporter 1	Mus musculus	182-186
31706864-3	2019	Considering the ability of hydroxypropyl-beta-cyclodextrin (HP-beta-CD, 100 mM) to increase the water solubility of BUD (SHP-beta-CD = 4.3 10-3 M; K1:1 = 861.11 M-1), a mucoadhesive thiolated HP-beta-CD (HP-beta-CD-SH) was synthesized and characterized by mass spectroscopy, 1H- and 13C NMR techniques.	2-Hydroxypropyl-beta-cyclodextrin	27-58	nuclear receptor subfamily 0 group B member 2	Homo sapiens	121-124
31706864-3	2019	Considering the ability of hydroxypropyl-beta-cyclodextrin (HP-beta-CD, 100 mM) to increase the water solubility of BUD (SHP-beta-CD = 4.3 10-3 M; K1:1 = 861.11 M-1), a mucoadhesive thiolated HP-beta-CD (HP-beta-CD-SH) was synthesized and characterized by mass spectroscopy, 1H- and 13C NMR techniques.	2-Hydroxypropyl-beta-cyclodextrin	27-58	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	125-132
31706864-3	2019	Considering the ability of hydroxypropyl-beta-cyclodextrin (HP-beta-CD, 100 mM) to increase the water solubility of BUD (SHP-beta-CD = 4.3 10-3 M; K1:1 = 861.11 M-1), a mucoadhesive thiolated HP-beta-CD (HP-beta-CD-SH) was synthesized and characterized by mass spectroscopy, 1H- and 13C NMR techniques.	2-Hydroxypropyl-beta-cyclodextrin	27-58	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	125-132
30639736-2	2019	In this study, we investigated the tolerability of a model freebase compound, GDC-0152, solubilized by pH adjustment with succinic acid and complexation with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) to enable intravenous use.	2-Hydroxypropyl-beta-cyclodextrin	158-189	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	194-201
31051283-2	2019	Our goal was to evaluate the mechanism of action of a previously described combination-therapy, Triple Combination Formulation (TCF) - comprised of the histone deacetylase inhibitor (HDACi) vorinostat/HPbetaCD/PEG - shown to prolong survival in Npc1 mice.	2-Hydroxypropyl-beta-cyclodextrin	201-209	NPC intracellular cholesterol transporter 1	Mus musculus	245-249
31408673-9	2019	Analysis of the combined effect of trehalose and HP-beta-CD on UV-Phb aggregation showed that protein aggregation was independently affected by trehalose and HP-beta-CD.	2-Hydroxypropyl-beta-cyclodextrin	49-59	prohibitin 1	Homo sapiens	66-69
31408673-9	2019	Analysis of the combined effect of trehalose and HP-beta-CD on UV-Phb aggregation showed that protein aggregation was independently affected by trehalose and HP-beta-CD.	2-Hydroxypropyl-beta-cyclodextrin	158-168	prohibitin 1	Homo sapiens	66-69
31425749-0	2019	An oral 2-hydroxypropyl-beta-cyclodextrin-loaded spirooxindole-pyrrolizidine derivative restores p53 activity via targeting MDM2 and JNK1/2 in hepatocellular carcinoma.	2-Hydroxypropyl-beta-cyclodextrin	8-41	tumor protein p53	Homo sapiens	97-100
31425749-0	2019	An oral 2-hydroxypropyl-beta-cyclodextrin-loaded spirooxindole-pyrrolizidine derivative restores p53 activity via targeting MDM2 and JNK1/2 in hepatocellular carcinoma.	2-Hydroxypropyl-beta-cyclodextrin	8-41	MDM2 proto-oncogene	Homo sapiens	124-128
31425749-0	2019	An oral 2-hydroxypropyl-beta-cyclodextrin-loaded spirooxindole-pyrrolizidine derivative restores p53 activity via targeting MDM2 and JNK1/2 in hepatocellular carcinoma.	2-Hydroxypropyl-beta-cyclodextrin	8-41	mitogen-activated protein kinase 8	Homo sapiens	133-137
31145948-7	2019	To produce needles of higher mechanical strength for successful insertion into the compact and hard HS tissue, hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was added into sodium hyaluronic acid (HA), the needle material.	2-Hydroxypropyl-beta-cyclodextrin	111-142	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	147-154
31776357-4	2019	2-hydroxypropyl-beta-Cyclodextrin (2HP-beta-CD) has been previously shown to reduce lysosomal cholesterol accumulation in a murine model of Niemann Pick Type C (NPC) disease.	2-Hydroxypropyl-beta-cyclodextrin	0-33	adrenocortical dysplasia	Mus musculus	39-46
31408673-3	2019	The effects of chemical chaperones trehalose and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on the kinetics of aggregation of UV-irradiated muscle glycogen phosphorylase b (UV-Phb) at 37  C have been studied.	2-Hydroxypropyl-beta-cyclodextrin	49-82	prohibitin 1	Homo sapiens	180-183
31408673-5	2019	It was shown that both trehalose and HP-beta-CD increased the duration of the nucleation phase and slowed down the rate of structural reorganization of the UV-Phb molecule.	2-Hydroxypropyl-beta-cyclodextrin	37-47	prohibitin 1	Homo sapiens	159-162
30753095-7	2019	7K-induced Eng expression was prevented by the treatment with 2-hydroxypropyl-beta-cyclodextrin; 8-{[5-chloro-2-(4-methylpiperazin-1-yl) pyridine-4-carbonyl] amino}-1-(4-fluorophenyl)-4, 5-dihydrobenzo[g]indazole-3-carboxamide; or by KLF6 silencing.	2-Hydroxypropyl-beta-cyclodextrin	62-95	endoglin	Mus musculus	11-14
30632402-2	2019	Hence, the present study is to synthesize N-trimethyl chitosan (TMC), a water-soluble chitosan derivative and to prepare flurbiprofen (FLU):hydroxyl propyl-beta-cyclodextrin (HP-beta-CD) complex-loaded nanoparticles for treatment of bacterial conjunctivitis which aims to increase the residence time in ocular tissue, thus enhancing patient compliance and improved efficacy.	2-Hydroxypropyl-beta-cyclodextrin	140-173	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	178-185
30753095-7	2019	7K-induced Eng expression was prevented by the treatment with 2-hydroxypropyl-beta-cyclodextrin; 8-{[5-chloro-2-(4-methylpiperazin-1-yl) pyridine-4-carbonyl] amino}-1-(4-fluorophenyl)-4, 5-dihydrobenzo[g]indazole-3-carboxamide; or by KLF6 silencing.	2-Hydroxypropyl-beta-cyclodextrin	62-95	Kruppel-like factor 6	Mus musculus	234-238
31372225-2	2019	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is an attractive drug candidate for treating NPC, as it diminishes cholesterol accumulation in NPC cells.	2-Hydroxypropyl-beta-cyclodextrin	0-31	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	36-43
30704045-3	2019	Based on these considerations, the purpose of this work was to use the strategy of complexation with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in order to obtain an aqueous preparation of DAS, which is characterized by a low water solubility (6.49 x 10-4 mg/mL).	2-Hydroxypropyl-beta-cyclodextrin	101-132	beta-carotene oxygenase 1	Mus musculus	137-144
30681344-0	2019	Host-Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2-Hydroxypropyl-beta-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism.	2-Hydroxypropyl-beta-cyclodextrin	98-131	angiotensinogen	Homo sapiens	163-177
32104450-2	2019	Complexation of DP with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was applied to mask the bitter taste then the prepared complexes were incorporated into ODF using solvent casting method.	2-Hydroxypropyl-beta-cyclodextrin	24-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	60-67
30342014-7	2019	Hydroxypropyl-beta-cyclodextrin is too bulky to enter MPO channel leading to the binding site suggesting a full release of curcumin from the cyclodextrin thereby allowing its full access to the active site of MPO.	2-Hydroxypropyl-beta-cyclodextrin	0-31	myeloperoxidase	Homo sapiens	54-57
30342014-7	2019	Hydroxypropyl-beta-cyclodextrin is too bulky to enter MPO channel leading to the binding site suggesting a full release of curcumin from the cyclodextrin thereby allowing its full access to the active site of MPO.	2-Hydroxypropyl-beta-cyclodextrin	0-31	myeloperoxidase	Homo sapiens	209-212
30176257-4	2018	In the present study, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was used to form a complex with Sit, namely the Sit-HP-beta-CD inclusion complex, and the inhibitory effect of this complex on adipogenesis in the 3T3-L1 pre-adipocyte cell line was investigated.	2-Hydroxypropyl-beta-cyclodextrin	22-55	beta-carotene oxygenase 1	Mus musculus	60-67
30541953-9	2018	In addition, the PTS + HPbetaCD complex also provoked increased catalase activity in both experimental protocols.	2-Hydroxypropyl-beta-cyclodextrin	23-31	catalase	Rattus norvegicus	64-72
28901794-5	2018	reports significantly decreased hepatocellular injury, Fas/FasL expression and inhibited HMGB1 release in rats receiving a hydrosoluble, lyophilized complex of SLB and hydroxypropyl-beta-cyclodextrin (SLB-HP-beta-CD) intravenously.	2-Hydroxypropyl-beta-cyclodextrin	168-199	high mobility group box 1	Rattus norvegicus	89-94
30392741-0	2018	Necroptosis inhibition as a therapy for Niemann-Pick disease, type C1: Inhibition of RIP kinases and combination therapy with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	126-159	NPC1 like intracellular cholesterol transporter 1	Mus musculus	40-69
30392741-11	2018	We thus investigated the potential of combining RIPK1 inhibition with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) therapy HPbetaCD has been shown to slow neurological disease progression in NPC1 mice, cats and patients.	2-Hydroxypropyl-beta-cyclodextrin	123-131	NPC1 like intracellular cholesterol transporter 1	Mus musculus	191-195
30392741-12	2018	HPbetaCD appeared to have an additive positive effect on the pathology and survival of Npc1-/-:Ripk1kd/kd mice.	2-Hydroxypropyl-beta-cyclodextrin	0-8	NPC intracellular cholesterol transporter 1	Mus musculus	87-91
30176257-4	2018	In the present study, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was used to form a complex with Sit, namely the Sit-HP-beta-CD inclusion complex, and the inhibitory effect of this complex on adipogenesis in the 3T3-L1 pre-adipocyte cell line was investigated.	2-Hydroxypropyl-beta-cyclodextrin	22-55	beta-carotene oxygenase 1	Mus musculus	124-131
30249300-8	2018	OHC loss and elevated thresholds were found for high frequency regions in NPC1-KO mice, whose OHCs retained their sensitivity to HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	129-137	NPC intracellular cholesterol transporter 1	Mus musculus	74-78
30424529-8	2018	The monotherapy with HPbetaCD led to an increase of 261% +- 10.5% compared to sham-treated Npc1-/- mice.	2-Hydroxypropyl-beta-cyclodextrin	21-29	NPC intracellular cholesterol transporter 1	Mus musculus	91-95
30293685-5	2018	To improve the solubility of compound 4p, we hosted this compound into the substituted glucopyranose ring of (2-Hydroxypropyl)-beta-cyclodextrin (HBC), a cosolvent approved by FDA with the help of ultrasonication and heating.	2-Hydroxypropyl-beta-cyclodextrin	109-144	keratin 88, pseudogene	Homo sapiens	146-149
30281958-0	2018	Lipase-catalyzed hydrolysis of (R,S)-2,3-diphenylpropionic methyl ester enhanced by hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	84-115	PAN0_003d1715	Moesziomyces antarcticus	0-6
30203709-3	2018	The present study aims to explore the effects of oral administration of PTS complexed with hydroxypropyl-beta-cyclodextrin HPbetaCD (PTS:HPbetaCD complex) on the glutathione cycle, thiol protein activities and signalling pathways involving the protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK-3beta) proteins in the left ventricle (LV) of infarcted rats.	2-Hydroxypropyl-beta-cyclodextrin	91-122	AKT serine/threonine kinase 1	Rattus norvegicus	262-265
30203709-3	2018	The present study aims to explore the effects of oral administration of PTS complexed with hydroxypropyl-beta-cyclodextrin HPbetaCD (PTS:HPbetaCD complex) on the glutathione cycle, thiol protein activities and signalling pathways involving the protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK-3beta) proteins in the left ventricle (LV) of infarcted rats.	2-Hydroxypropyl-beta-cyclodextrin	91-122	glycogen synthase kinase 3 beta	Rattus norvegicus	271-301
30203709-3	2018	The present study aims to explore the effects of oral administration of PTS complexed with hydroxypropyl-beta-cyclodextrin HPbetaCD (PTS:HPbetaCD complex) on the glutathione cycle, thiol protein activities and signalling pathways involving the protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK-3beta) proteins in the left ventricle (LV) of infarcted rats.	2-Hydroxypropyl-beta-cyclodextrin	91-122	glycogen synthase kinase 3 beta	Rattus norvegicus	303-312
30203709-5	2018	The results showed that the PBS: HPbetaCD complex decreased lipid peroxidation, prevented the decrease in thioredoxin reductase (TRxR) activity, and increased the activity of glutathione-S-transferase (GST) and glutaredoxin (GRx).	2-Hydroxypropyl-beta-cyclodextrin	33-41	peroxiredoxin 5	Rattus norvegicus	106-127
30203709-5	2018	The results showed that the PBS: HPbetaCD complex decreased lipid peroxidation, prevented the decrease in thioredoxin reductase (TRxR) activity, and increased the activity of glutathione-S-transferase (GST) and glutaredoxin (GRx).	2-Hydroxypropyl-beta-cyclodextrin	33-41	peroxiredoxin 5	Rattus norvegicus	129-133
30203709-5	2018	The results showed that the PBS: HPbetaCD complex decreased lipid peroxidation, prevented the decrease in thioredoxin reductase (TRxR) activity, and increased the activity of glutathione-S-transferase (GST) and glutaredoxin (GRx).	2-Hydroxypropyl-beta-cyclodextrin	33-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	175-200
30203709-5	2018	The results showed that the PBS: HPbetaCD complex decreased lipid peroxidation, prevented the decrease in thioredoxin reductase (TRxR) activity, and increased the activity of glutathione-S-transferase (GST) and glutaredoxin (GRx).	2-Hydroxypropyl-beta-cyclodextrin	33-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	202-205
30203709-5	2018	The results showed that the PBS: HPbetaCD complex decreased lipid peroxidation, prevented the decrease in thioredoxin reductase (TRxR) activity, and increased the activity of glutathione-S-transferase (GST) and glutaredoxin (GRx).	2-Hydroxypropyl-beta-cyclodextrin	33-41	glutaredoxin	Rattus norvegicus	211-223
30203709-5	2018	The results showed that the PBS: HPbetaCD complex decreased lipid peroxidation, prevented the decrease in thioredoxin reductase (TRxR) activity, and increased the activity of glutathione-S-transferase (GST) and glutaredoxin (GRx).	2-Hydroxypropyl-beta-cyclodextrin	33-41	glutaredoxin	Rattus norvegicus	225-228
30135069-3	2018	Both mouse and feline models of NPC1 mimic the disease progression in humans and have been used in preclinical studies of 2-hydroxypropyl-beta-cyclodextrin (2HPbetaCD; VTS-270), a drug that appeared to slow neurological progression in a Phase 1/2 clinical trial.	2-Hydroxypropyl-beta-cyclodextrin	122-155	NPC intracellular cholesterol transporter 1	Mus musculus	32-36
30214897-5	2018	As this compound presents low solubility and high toxicity in human clinical trials, we prepared an inclusion complex containing hydroxypropyl-beta-cyclodextrin and 17-AAG (17-AAG:HPbetaCD) to improve its solubility.	2-Hydroxypropyl-beta-cyclodextrin	129-160	N-methylpurine DNA glycosylase	Homo sapiens	176-179
30214897-5	2018	As this compound presents low solubility and high toxicity in human clinical trials, we prepared an inclusion complex containing hydroxypropyl-beta-cyclodextrin and 17-AAG (17-AAG:HPbetaCD) to improve its solubility.	2-Hydroxypropyl-beta-cyclodextrin	180-188	N-methylpurine DNA glycosylase	Homo sapiens	168-171
30214897-10	2018	Stability studies revealed that 17-AAG:HPbetaCD-loaded liposomes were smaller than 200 nm, with 99% EE.	2-Hydroxypropyl-beta-cyclodextrin	39-47	nitrogen permease regulator-like 3	Mus musculus	35-38
29803791-3	2018	In this study, an inclusion complex of MLT with 2-hydroxypropyl beta-cyclodextrin (HP-beta-CD) was prepared to improve the water solubility, and the osteogenic differentiation ability of the inclusion complex was investigated in MC3T3-E1 cells.	2-Hydroxypropyl-beta-cyclodextrin	48-81	beta-carotene oxygenase 1	Mus musculus	86-93
30135069-3	2018	Both mouse and feline models of NPC1 mimic the disease progression in humans and have been used in preclinical studies of 2-hydroxypropyl-beta-cyclodextrin (2HPbetaCD; VTS-270), a drug that appeared to slow neurological progression in a Phase 1/2 clinical trial.	2-Hydroxypropyl-beta-cyclodextrin	157-166	NPC intracellular cholesterol transporter 1	Mus musculus	32-36
30135069-10	2018	As a proof of principle, we were able to show that treatment of the npc1 mutant larvae with 2HPbetaCD significantly reduced neuromast LysoTracker staining.	2-Hydroxypropyl-beta-cyclodextrin	92-101	Niemann-Pick disease, type C1	Danio rerio	68-72
28927751-2	2017	The interaction of A1 with HP-betaCD resulted in the inclusion complex A1/HP-betaCD in 1:1 stoichiometry.	2-Hydroxypropyl-beta-cyclodextrin	27-36	brain protein 1	Mus musculus	71-83
29617956-5	2018	Treatment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a drug currently being studied in a phase 2b/3 clinical trial, reversed all microglia-associated defects in Npc1-/- animals.	2-Hydroxypropyl-beta-cyclodextrin	15-48	NPC intracellular cholesterol transporter 1	Homo sapiens	169-173
29617956-5	2018	Treatment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), a drug currently being studied in a phase 2b/3 clinical trial, reversed all microglia-associated defects in Npc1-/- animals.	2-Hydroxypropyl-beta-cyclodextrin	50-58	NPC intracellular cholesterol transporter 1	Homo sapiens	169-173
29617956-7	2018	We identified CD22 as a marker of dysregulated microglia in Npc1 mutant mice and subsequently demonstrated that elevated cerebrospinal fluid levels of CD22 in NPC1 patients responds to HPbetaCD administration.	2-Hydroxypropyl-beta-cyclodextrin	185-193	CD22 antigen	Mus musculus	14-18
29617956-7	2018	We identified CD22 as a marker of dysregulated microglia in Npc1 mutant mice and subsequently demonstrated that elevated cerebrospinal fluid levels of CD22 in NPC1 patients responds to HPbetaCD administration.	2-Hydroxypropyl-beta-cyclodextrin	185-193	NPC intracellular cholesterol transporter 1	Mus musculus	60-64
29617956-7	2018	We identified CD22 as a marker of dysregulated microglia in Npc1 mutant mice and subsequently demonstrated that elevated cerebrospinal fluid levels of CD22 in NPC1 patients responds to HPbetaCD administration.	2-Hydroxypropyl-beta-cyclodextrin	185-193	CD22 antigen	Mus musculus	151-155
29617956-7	2018	We identified CD22 as a marker of dysregulated microglia in Npc1 mutant mice and subsequently demonstrated that elevated cerebrospinal fluid levels of CD22 in NPC1 patients responds to HPbetaCD administration.	2-Hydroxypropyl-beta-cyclodextrin	185-193	NPC intracellular cholesterol transporter 1	Mus musculus	159-163
29663576-9	2018	In this study, we tested systemic post-stroke treatments using a molecule where Ang-(1-7) is included within hydroxypropyl-beta-cyclodextrin [HPbetaCD-Ang-(1-7)] as an orally bioavailable treatment.	2-Hydroxypropyl-beta-cyclodextrin	142-151	angiogenin	Rattus norvegicus	80-83
29663576-11	2018	The results indicate that post-stroke oral administration of HPbetaCD-Ang-(1-7) resulted in 25% reductions in cerebral infarct volumes and improvement in neurological functions (P &lt; 0.05), without inducing any alterations in blood pressure, heart rate or cerebral blood flow.	2-Hydroxypropyl-beta-cyclodextrin	61-69	angiogenin	Rattus norvegicus	70-73
29411332-1	2018	We have tested the efficacy of hydroxypropyl-beta-cyclodextrin (HPBCD) delivered by the nasal route in the mouse model of juvenile Niemann-Pick C1 disease (NPC1), as pulmonary disease has not responded to systemic therapy with this drug.	2-Hydroxypropyl-beta-cyclodextrin	31-62	NPC intracellular cholesterol transporter 1	Mus musculus	156-160
29411332-1	2018	We have tested the efficacy of hydroxypropyl-beta-cyclodextrin (HPBCD) delivered by the nasal route in the mouse model of juvenile Niemann-Pick C1 disease (NPC1), as pulmonary disease has not responded to systemic therapy with this drug.	2-Hydroxypropyl-beta-cyclodextrin	64-69	NPC intracellular cholesterol transporter 1	Mus musculus	156-160
29587349-9	2018	However, HPbetaCD monotherapy additionally increased cholesterol synthesis as indicated by a marked increase of the HMG-CoA and srebp-2 mRNA expression, probably as a result of increased hepatocellular proliferation.	2-Hydroxypropyl-beta-cyclodextrin	9-17	sterol regulatory element binding factor 2	Mus musculus	128-135
29346563-5	2018	Biweekly intrathecal administration of 2-hydroxypropyl-beta cyclodextrin (HPbetaCD) ameliorated neurological dysfunction, reduced cholesterol and sphingolipid accumulation, and increased lifespan in NPC1 cats.	2-Hydroxypropyl-beta-cyclodextrin	39-72	NPC intracellular cholesterol transporter 1	Felis catus	199-203
29346563-5	2018	Biweekly intrathecal administration of 2-hydroxypropyl-beta cyclodextrin (HPbetaCD) ameliorated neurological dysfunction, reduced cholesterol and sphingolipid accumulation, and increased lifespan in NPC1 cats.	2-Hydroxypropyl-beta-cyclodextrin	74-82	NPC intracellular cholesterol transporter 1	Felis catus	199-203
29346563-7	2018	This study is the first to (i) identify specific brain regions exhibiting autophagic abnormalities in any species with NPC1, (ii) provide evidence of differential vulnerability among discrete brain nuclei and pathways, and (iii) show the amelioration of these abnormalities in NPC1 cats treated with HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	300-308	NPC intracellular cholesterol transporter 1	Felis catus	277-281
29390035-0	2018	Correction: Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1.	2-Hydroxypropyl-beta-cyclodextrin	32-64	NPC intracellular cholesterol transporter 1	Homo sapiens	90-118
29138063-2	2018	Although 2-hydroxypropyl beta-cyclodextrin (HP-beta-CD) promotes the excretion of cholesterol and prolongs the life span in animal models of NPC disease, it requires extremely high dose.	2-Hydroxypropyl-beta-cyclodextrin	9-42	beta-carotene oxygenase 1	Mus musculus	47-54
29180229-8	2018	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), an activator of the transcription factor TFEB, which regulates expression of genes involved in autophagy and lysosome function, mitigates damage of pexophagy and decreases ROS production induced by doxorubicin.	2-Hydroxypropyl-beta-cyclodextrin	0-33	transcription factor EB	Homo sapiens	87-91
29180229-8	2018	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD), an activator of the transcription factor TFEB, which regulates expression of genes involved in autophagy and lysosome function, mitigates damage of pexophagy and decreases ROS production induced by doxorubicin.	2-Hydroxypropyl-beta-cyclodextrin	35-43	transcription factor EB	Homo sapiens	87-91
28829147-4	2017	Docking simulations of 2892 commercially available approved drugs indicated that L-PGDS shows higher binding affinities for various drugs compared with 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	152-185	prostaglandin D2 synthase	Homo sapiens	81-87
28803710-2	2017	In preclinical testing, 2-hydroxypropyl-beta-cyclodextrins (HPbetaCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1.	2-Hydroxypropyl-beta-cyclodextrin	24-58	NPC intracellular cholesterol transporter 1	Mus musculus	224-228
28803710-2	2017	In preclinical testing, 2-hydroxypropyl-beta-cyclodextrins (HPbetaCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1.	2-Hydroxypropyl-beta-cyclodextrin	60-68	NPC intracellular cholesterol transporter 1	Mus musculus	224-228
28803710-4	2017	METHODS: In this open-label, dose-escalation phase 1-2a study, we gave monthly intrathecal HPbetaCD to participants with NPC1 with neurological manifestation at the National Institutes of Health (NIH), Bethesda, MD, USA.	2-Hydroxypropyl-beta-cyclodextrin	91-99	NPC intracellular cholesterol transporter 1	Homo sapiens	121-125
28803710-23	2017	CSF 24(S)-HC concentrations in three participants given either 600 or 900 mg of HPbetaCD were increased about two fold (p=0 0032) after drug administration.	2-Hydroxypropyl-beta-cyclodextrin	80-88	colony stimulating factor 2	Homo sapiens	0-3
28155026-16	2017	HP-beta-CD could help stabilize NP-C with low toxicity potential, although some AEs have been reported.	2-Hydroxypropyl-beta-cyclodextrin	0-10	NPC intracellular cholesterol transporter 1	Homo sapiens	32-36
28628327-5	2017	Treatment of Npc1 KO CHO cells with 2-hydroxypropyl-beta-cyclodextrin (HPBCD), which can reduce cholesterol and glycosphingolipid (GSL) storage, did not affect the glycomic alterations observed in the GSL-, N-, and O-glycans of Npc1 KO CHO cells.	2-Hydroxypropyl-beta-cyclodextrin	36-69	NPC intracellular cholesterol transporter 1	Cricetulus griseus	13-17
28628327-5	2017	Treatment of Npc1 KO CHO cells with 2-hydroxypropyl-beta-cyclodextrin (HPBCD), which can reduce cholesterol and glycosphingolipid (GSL) storage, did not affect the glycomic alterations observed in the GSL-, N-, and O-glycans of Npc1 KO CHO cells.	2-Hydroxypropyl-beta-cyclodextrin	71-76	NPC intracellular cholesterol transporter 1	Cricetulus griseus	13-17
28628327-5	2017	Treatment of Npc1 KO CHO cells with 2-hydroxypropyl-beta-cyclodextrin (HPBCD), which can reduce cholesterol and glycosphingolipid (GSL) storage, did not affect the glycomic alterations observed in the GSL-, N-, and O-glycans of Npc1 KO CHO cells.	2-Hydroxypropyl-beta-cyclodextrin	71-76	NPC intracellular cholesterol transporter 1	Cricetulus griseus	228-232
28526856-2	2017	Here we show that HPbetaCD addition mitigates these adverse effects in human fibroblasts by significantly reducing LDLr and SREBP1 gene expression.	2-Hydroxypropyl-beta-cyclodextrin	18-26	low density lipoprotein receptor	Homo sapiens	115-119
28526856-2	2017	Here we show that HPbetaCD addition mitigates these adverse effects in human fibroblasts by significantly reducing LDLr and SREBP1 gene expression.	2-Hydroxypropyl-beta-cyclodextrin	18-26	sterol regulatory element binding transcription factor 1	Homo sapiens	124-130
28155026-3	2017	The investigational use of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) showed a promising role in treating NP-C, although efficacy and safety have not been established.	2-Hydroxypropyl-beta-cyclodextrin	27-60	NPC intracellular cholesterol transporter 1	Homo sapiens	110-114
28155026-3	2017	The investigational use of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) showed a promising role in treating NP-C, although efficacy and safety have not been established.	2-Hydroxypropyl-beta-cyclodextrin	62-72	NPC intracellular cholesterol transporter 1	Homo sapiens	110-114
28155026-17	2017	Moreover, controlled clinical trials would be necessary to evaluate the role of HP-beta-CD in NP-C.	2-Hydroxypropyl-beta-cyclodextrin	80-90	NPC intracellular cholesterol transporter 1	Homo sapiens	94-98
28452365-3	2017	Recently, the cycloheptaglucoside 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) has shown efficacy as a potential NPC therapeutic by extending lifetime in NPC mice, delaying neurodegeneration, and decreasing visceral and neurological cholesterol burden.	2-Hydroxypropyl-beta-cyclodextrin	34-67	beta-carotene oxygenase 1	Mus musculus	72-79
28414792-0	2017	Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1.	2-Hydroxypropyl-beta-cyclodextrin	20-52	NPC intracellular cholesterol transporter 1	Homo sapiens	78-106
28414792-1	2017	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Homo sapiens	238-242
28414792-1	2017	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Homo sapiens	238-242
28383485-6	2017	Additionally, after administration of two different therapy approaches using either a combination of miglustat, 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and allopregnanolone or a monotherapy with HPbetaCD, we recorded a remarkable reduction of morphological damages in NPC1-/- mice and an up to four-fold increase of proliferating cells within the olfactory epithelium.	2-Hydroxypropyl-beta-cyclodextrin	112-145	NPC1 like intracellular cholesterol transporter 1	Mus musculus	273-277
28638736-9	2017	We further demonstrate that the activation of TFEB by hydroxypropyl-beta-cyclodextrin in macrophages suppressed their M2 polarization and tumor-promoting capacity, and that macrophage-specific TFEB overexpression inhibited breast tumor growth in mice.	2-Hydroxypropyl-beta-cyclodextrin	54-85	transcription factor EB	Mus musculus	46-50
27714322-3	2016	The solubilizing efficiency of the TTP inclusion complex is enhanced in the order of DMbetaCD &gt; HPbetaCD &gt; betaCD.	2-Hydroxypropyl-beta-cyclodextrin	99-107	ZFP36 ring finger protein	Homo sapiens	35-38
28347782-5	2017	Hydroxypropyl-beta-Cyclodextrin (HPbetaCD) was the best CD studied for encapsulating t10,c12-CLA.	2-Hydroxypropyl-beta-cyclodextrin	0-31	selectin P ligand	Homo sapiens	93-96
28347782-5	2017	Hydroxypropyl-beta-Cyclodextrin (HPbetaCD) was the best CD studied for encapsulating t10,c12-CLA.	2-Hydroxypropyl-beta-cyclodextrin	33-41	selectin P ligand	Homo sapiens	93-96
28347782-6	2017	The resulting t10,c12-CLA-HPbetaCD complex showed a very high dependency on pH, which explains why a pKa of 4.08 was found for first time, which was very close to the simulated value.	2-Hydroxypropyl-beta-cyclodextrin	26-34	selectin P ligand	Homo sapiens	22-25
27692470-8	2017	Another therapeutic candidate can be broad-acting 2-hydroxypropyl-beta-cyclodextrin, a compound that targets several mechanisms such as cholesterol efflux, complement gene expression, and the NLRP3 pathway.	2-Hydroxypropyl-beta-cyclodextrin	50-83	NLR family pyrin domain containing 3	Homo sapiens	192-197
32104329-1	2017	The goal of this study was to improve the solubility and oral bioavailability of tamibarotene by complexing it with hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	116-147	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	152-159
32104329-2	2017	The inclusion complex of tamibarotene with hydroxypropyl-beta-cyclodextrin (Am80-HP-beta-CD) was prepared through a freeze-drying method at the mole ratio of 1:1 (Am80: HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	43-74	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	84-91
32104329-2	2017	The inclusion complex of tamibarotene with hydroxypropyl-beta-cyclodextrin (Am80-HP-beta-CD) was prepared through a freeze-drying method at the mole ratio of 1:1 (Am80: HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	43-74	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	172-179
28179943-2	2017	Currently, treatment of NPC involves the use of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	48-81	NPC intracellular cholesterol transporter 1	Homo sapiens	24-27
28179943-2	2017	Currently, treatment of NPC involves the use of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	83-93	NPC intracellular cholesterol transporter 1	Homo sapiens	24-27
28179943-4	2017	One of the methods to reduce the required dose of HP-beta-CD for treatment of NPC is to actively targeting hepatocytes with beta-cyclodextrin (beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	50-60	NPC intracellular cholesterol transporter 1	Homo sapiens	78-81
29065825-0	2017	2-Hydroxypropyl-beta-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1.	2-Hydroxypropyl-beta-cyclodextrin	0-34	NPC1 like intracellular cholesterol transporter 1	Mus musculus	83-111
29065825-3	2017	Animal investigations of 2-hydroxypropyl-beta-cyclodextrins (HPbetaCD) in NPC1 in mice demonstrated that HPbetaCD does not cross the blood-brain barrier in significant amounts but suggested a potential for these complex oligosaccharides to moderately impact CNS manifestations when administered subcutaneously or intraperitoneally at very high doses; however, safety concerns regarding pulmonary toxicity were raised.	2-Hydroxypropyl-beta-cyclodextrin	25-59	NPC1 like intracellular cholesterol transporter 1	Mus musculus	74-78
29065825-3	2017	Animal investigations of 2-hydroxypropyl-beta-cyclodextrins (HPbetaCD) in NPC1 in mice demonstrated that HPbetaCD does not cross the blood-brain barrier in significant amounts but suggested a potential for these complex oligosaccharides to moderately impact CNS manifestations when administered subcutaneously or intraperitoneally at very high doses; however, safety concerns regarding pulmonary toxicity were raised.	2-Hydroxypropyl-beta-cyclodextrin	61-69	NPC1 like intracellular cholesterol transporter 1	Mus musculus	74-78
29065825-3	2017	Animal investigations of 2-hydroxypropyl-beta-cyclodextrins (HPbetaCD) in NPC1 in mice demonstrated that HPbetaCD does not cross the blood-brain barrier in significant amounts but suggested a potential for these complex oligosaccharides to moderately impact CNS manifestations when administered subcutaneously or intraperitoneally at very high doses; however, safety concerns regarding pulmonary toxicity were raised.	2-Hydroxypropyl-beta-cyclodextrin	105-113	NPC1 like intracellular cholesterol transporter 1	Mus musculus	74-78
26845478-3	2016	In this study, the inclusion complexes of simvastatin (SV) with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated beta-cyclodextrin (RM-beta-CD) were prepared to improve the water-solubility and the osteogenic differentiation ability of the inclusion complexes in MC3T3-E1 cells was investigated.	2-Hydroxypropyl-beta-cyclodextrin	64-95	beta-carotene oxygenase 1	Mus musculus	100-107
27812358-1	2016	2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient.	2-Hydroxypropyl-beta-cyclodextrin	0-33	beta-carotene oxygenase 1	Mus musculus	38-45
27903454-7	2017	Our studies revealed that PEG, HPCD, SOL, CrEL, Tw20 and Tw80 were potent inhibitors of OCT1-3 (e.g., Tw20 IC50 values&lt;0.04%).	2-Hydroxypropyl-beta-cyclodextrin	31-35	solute carrier family 22 member 2	Canis lupus familiaris	88-94
27269370-2	2017	To improve its in vivo behavior and water-solubility, a Hydroxypropyl-beta-Cyclodextrin (HP-beta-CD) inclusion complex of 16-DHP was prepared in this paper.	2-Hydroxypropyl-beta-cyclodextrin	56-87	beta-carotene oxygenase 1	Mus musculus	92-99
27269370-2	2017	To improve its in vivo behavior and water-solubility, a Hydroxypropyl-beta-Cyclodextrin (HP-beta-CD) inclusion complex of 16-DHP was prepared in this paper.	2-Hydroxypropyl-beta-cyclodextrin	56-87	dihydropyrimidinase	Rattus norvegicus	125-128
28154534-3	2017	HPbetaCD/BCP and AM630 were then administered to VD rats to upregulate and downregulate the cannabinoid receptor type 2 (CB2).	2-Hydroxypropyl-beta-cyclodextrin	0-8	cannabinoid receptor 2	Rattus norvegicus	121-124
28154534-7	2017	Moreover, molecular biology experiments showed that HPbetaCD/BCP can increase the expression levels of CB2 in brain tissues, particularly the hippocampus and white matter tissues, as well as the expression levels of PI3K and Akt.	2-Hydroxypropyl-beta-cyclodextrin	52-60	cannabinoid receptor 2	Rattus norvegicus	103-106
28154534-7	2017	Moreover, molecular biology experiments showed that HPbetaCD/BCP can increase the expression levels of CB2 in brain tissues, particularly the hippocampus and white matter tissues, as well as the expression levels of PI3K and Akt.	2-Hydroxypropyl-beta-cyclodextrin	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	225-228
29090040-3	2017	Here, we evaluate the antioxidant capacities of astaxanthin included within hydroxypropyl-beta-cyclodextrin (CD-A) to directly and indirectly reduce the induced ROS production.	2-Hydroxypropyl-beta-cyclodextrin	76-107	cytidine deaminase	Homo sapiens	109-113
27992857-8	2016	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), an activator of TFEB, also promoted neuronal survival, decreased the levels of p62, and lowered the pH in lysosomes.	2-Hydroxypropyl-beta-cyclodextrin	0-33	transcription factor EB	Homo sapiens	62-66
27992857-8	2016	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), an activator of TFEB, also promoted neuronal survival, decreased the levels of p62, and lowered the pH in lysosomes.	2-Hydroxypropyl-beta-cyclodextrin	0-33	nucleoporin 62	Homo sapiens	125-128
27992857-8	2016	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), an activator of TFEB, also promoted neuronal survival, decreased the levels of p62, and lowered the pH in lysosomes.	2-Hydroxypropyl-beta-cyclodextrin	35-43	transcription factor EB	Homo sapiens	62-66
27992857-8	2016	2-Hydroxypropyl-beta-cyclodextrin (HPbetaCD), an activator of TFEB, also promoted neuronal survival, decreased the levels of p62, and lowered the pH in lysosomes.	2-Hydroxypropyl-beta-cyclodextrin	35-43	nucleoporin 62	Homo sapiens	125-128
27418290-0	2016	Effect of hydroxypropyl-beta-cyclodextrin on the bounding of salazosulfapyridine to human serum albumin.	2-Hydroxypropyl-beta-cyclodextrin	10-41	albumin	Homo sapiens	90-103
27317367-1	2016	The objective of this study was to assess the antioxidant ability of C60(OH)10/2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) nanoparticles, by comparing their scavenging ability for reactive nitrogen species, their cytoprotective effects under conditions of oxidative stress, and their therapeutic effects against diseases that are induced by oxidative stress.	2-Hydroxypropyl-beta-cyclodextrin	81-112	beta-carotene oxygenase 1	Mus musculus	117-124
27586038-10	2016	Two sequential 2-hydroxypropyl-beta-cyclodextrin administrations at PN4 and PN7 counteract these defects, partially preventing functional impairment of BG and fully restoring the normal patterns of glutamatergic/GABAergic stimulation to PCs.These findings indicate that in Npc1 (nmf164) homozygous mice the derangement of synaptic connectivity and dysmyelination during cerebellar morphogenesis largely anticipate motor deficits that are typically observed during adulthood.	2-Hydroxypropyl-beta-cyclodextrin	15-48	NPC intracellular cholesterol transporter 1	Mus musculus	273-277
27586038-10	2016	Two sequential 2-hydroxypropyl-beta-cyclodextrin administrations at PN4 and PN7 counteract these defects, partially preventing functional impairment of BG and fully restoring the normal patterns of glutamatergic/GABAergic stimulation to PCs.These findings indicate that in Npc1 (nmf164) homozygous mice the derangement of synaptic connectivity and dysmyelination during cerebellar morphogenesis largely anticipate motor deficits that are typically observed during adulthood.	2-Hydroxypropyl-beta-cyclodextrin	15-48	NPC intracellular cholesterol transporter 1	Mus musculus	279-285
27307499-6	2016	Biweekly intrathecal administration of HPbetaCD initiated prior to the onset of neurologic dysfunction completely normalized CSF calbindin in NPC1 cats at all time points analyzed when followed up to 78 weeks of age.	2-Hydroxypropyl-beta-cyclodextrin	39-47	calbindin 1	Homo sapiens	129-138
27572704-1	2016	2-Hydroxy-propyl-beta-cyclodextrin (HPbetaCD), a cholesterol scavenger, is currently undergoing Phase 2b/3 clinical trial for treatment of Niemann Pick Type C-1 (NPC1), a fatal neurodegenerative disorder that stems from abnormal cholesterol accumulation in the endo/lysosomes.	2-Hydroxypropyl-beta-cyclodextrin	36-44	NPC intracellular cholesterol transporter 1	Homo sapiens	139-160
27572704-1	2016	2-Hydroxy-propyl-beta-cyclodextrin (HPbetaCD), a cholesterol scavenger, is currently undergoing Phase 2b/3 clinical trial for treatment of Niemann Pick Type C-1 (NPC1), a fatal neurodegenerative disorder that stems from abnormal cholesterol accumulation in the endo/lysosomes.	2-Hydroxypropyl-beta-cyclodextrin	36-44	NPC intracellular cholesterol transporter 1	Homo sapiens	162-166
27353207-8	2016	Treatment with HP-CD microspheres against Abeta(1-42) significantly reduced DNA fragmentation and increased the Bcl-2/Bax mRNA ratio and mitochondrial function.	2-Hydroxypropyl-beta-cyclodextrin	15-20	BCL2, apoptosis regulator	Rattus norvegicus	112-117
27353207-8	2016	Treatment with HP-CD microspheres against Abeta(1-42) significantly reduced DNA fragmentation and increased the Bcl-2/Bax mRNA ratio and mitochondrial function.	2-Hydroxypropyl-beta-cyclodextrin	15-20	BCL2 associated X, apoptosis regulator	Rattus norvegicus	118-121
27307499-6	2016	Biweekly intrathecal administration of HPbetaCD initiated prior to the onset of neurologic dysfunction completely normalized CSF calbindin in NPC1 cats at all time points analyzed when followed up to 78 weeks of age.	2-Hydroxypropyl-beta-cyclodextrin	39-47	NPC intracellular cholesterol transporter 1	Felis catus	142-146
27307499-7	2016	Initiation of HPbetaCD after the onset of clinical signs (16 weeks of age) resulted in a delayed reduction of calbindin levels in the CSF.	2-Hydroxypropyl-beta-cyclodextrin	14-22	calbindin 1	Homo sapiens	110-119
27458481-8	2016	The caspase-3 enzyme activity analysis and Annexin V/PI double-staining revealed that EVO/HP-beta-CD inclusion complexes possessed better antitumor activities than evodiamine.	2-Hydroxypropyl-beta-cyclodextrin	90-100	caspase 3	Homo sapiens	4-13
27458481-8	2016	The caspase-3 enzyme activity analysis and Annexin V/PI double-staining revealed that EVO/HP-beta-CD inclusion complexes possessed better antitumor activities than evodiamine.	2-Hydroxypropyl-beta-cyclodextrin	90-100	annexin A5	Homo sapiens	43-52
27160037-2	2016	In this study, we examined whether hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a widely used pharmaceutical excipient to improve solubility and drug delivery, can act as a mucosal adjuvant for intranasal flu vaccines.	2-Hydroxypropyl-beta-cyclodextrin	35-66	beta-carotene oxygenase 1	Mus musculus	71-78
27288778-0	2016	Use of 2 hydroxypropyl-beta-cyclodextrin therapy in two adult Niemann Pick Type C patients.	2-Hydroxypropyl-beta-cyclodextrin	7-40	protein interacting with PRKCA 1	Homo sapiens	70-74
27040215-5	2016	The detailed characterization techniques (XRD, TGA and (1)H-NMR) confirmed the formation of inclusion complex between GA and HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	125-133	T-box transcription factor 1	Homo sapiens	47-50
27061827-1	2016	OBJECTIVES: The aim of this study was to observe the effect multilamellar liposomes (MLV) and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in the in-vitro effects of lidocaine in cell viability, pro-inflammatory cytokines and prostaglandin E2 release of both human keratinocytes (HaCaT) and gingival fibroblasts (HGF) cells.	2-Hydroxypropyl-beta-cyclodextrin	129-139	hepatocyte growth factor	Homo sapiens	315-318
26250106-6	2016	It was confirmed that the precipitate that was formed by zinc ions in the presence of HPbetaCD and DF-Na contained no cyclodextrin and most likely it was a mixture of the complexes: DF2-Zn and DF-Zn with some molecules of water.	2-Hydroxypropyl-beta-cyclodextrin	86-94	serine protease 57	Rattus norvegicus	182-185
27241174-4	2016	report that CD mediates regression of atherosclerotic plaques in two mouse models by solubilizing cholesterol crystals (CCs), and promoting metabolism of CCs into water-soluble 27-hydroxycholesterol, which, in turn, activates anti-inflammatory LXR receptor target genes, promotes active and passive efflux of cholesterol from macrophages, and increases metabolic processing of cholesterol.	2-Hydroxypropyl-beta-cyclodextrin	12-14	nuclear receptor subfamily 1, group H, member 3	Mus musculus	244-247
26903308-2	2016	Recent studies reported ototoxicity of 2-hydroxypropyl- beta-cyclodextrin (HPbetaCD), a cholesterol chelator and the only promising treatment for NPC1.	2-Hydroxypropyl-beta-cyclodextrin	39-73	NPC intracellular cholesterol transporter 1	Mus musculus	146-150
26903308-2	2016	Recent studies reported ototoxicity of 2-hydroxypropyl- beta-cyclodextrin (HPbetaCD), a cholesterol chelator and the only promising treatment for NPC1.	2-Hydroxypropyl-beta-cyclodextrin	75-83	NPC intracellular cholesterol transporter 1	Mus musculus	146-150
26903308-4	2016	Single, high-dose administration of HPbetaCD resulted in OHC death in prestin wildtype (WT) mice whereas OHCs were largely spared in prestin knockout (KO) mice in the basal region, implicating prestin"s involvement in ototoxicity of HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	36-44	solute carrier family 26, member 5	Mus musculus	70-77
26903308-5	2016	We found that prestin can interact with cholesterol in vitro, suggesting that HPbetaCD-induced ototoxicity may involve disruption of this interaction.	2-Hydroxypropyl-beta-cyclodextrin	78-86	solute carrier family 26, member 5	Mus musculus	14-21
26664628-2	2015	Currently, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) has been applied for the treatment of NPC.	2-Hydroxypropyl-beta-cyclodextrin	11-44	NPC intracellular cholesterol transporter 1	Homo sapiens	97-100
26288996-6	2016	It was confirmed that the precipitate that was formed by zinc ions in the presence of HPbetaCD and DF-Na contained no cyclodextrin and most likely it was a mixture of the complexes: DF2-Zn and DF-Zn with some molecules of water.	2-Hydroxypropyl-beta-cyclodextrin	86-94	serine protease 57	Rattus norvegicus	182-185
26664628-2	2015	Currently, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) has been applied for the treatment of NPC.	2-Hydroxypropyl-beta-cyclodextrin	46-57	NPC intracellular cholesterol transporter 1	Homo sapiens	97-100
26664628-3	2015	HP-beta-CyD improved hepatosplenomegaly in NPC patients, however, a high dose of HP-beta-CyD was necessary.	2-Hydroxypropyl-beta-cyclodextrin	0-11	NPC intracellular cholesterol transporter 1	Homo sapiens	43-46
26404254-0	2015	Weekly Treatment of 2-Hydroxypropyl-beta-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice.	2-Hydroxypropyl-beta-cyclodextrin	20-53	low density lipoprotein receptor	Mus musculus	99-111
26392920-4	2015	By means of patch clamp recordings, we measured inhibitory postsynaptic currents (IPSCs) of CA1 pyramidal cells of CDX-treated and -untreated animals to elucidate the influence of CDX on the synaptic transmission.	2-Hydroxypropyl-beta-cyclodextrin	115-118	carbonic anhydrase 1	Mus musculus	92-95
26392920-5	2015	Surprisingly, CDX induced a significantly higher GABAergic IPSC frequency in wild-type mice than in NPC1(-/-) mice.	2-Hydroxypropyl-beta-cyclodextrin	14-17	NPC intracellular cholesterol transporter 1	Mus musculus	100-104
26392920-8	2015	However, the unexpected effect of CDX on the GABAergic synaptic transmission is of special interest as a disturbance plays, for example, a crucial role in epilepsy and, moreover, as CDX is currently under investigation as a treatment for NPC1 in humans.	2-Hydroxypropyl-beta-cyclodextrin	182-185	NPC intracellular cholesterol transporter 1	Homo sapiens	238-242
25790376-5	2015	Furthermore, we showed that pharmacological activation of TFEB using 2-hydroxypropyl-beta-cyclodextrin promotes autophagic clearance of aggregated alpha-syn.	2-Hydroxypropyl-beta-cyclodextrin	69-102	transcription factor EB	Homo sapiens	58-62
25987212-0	2015	Insulin complexation with hydroxypropyl-beta-cyclodextrin: Spectroscopic evaluation of molecular inclusion and use of the complex in gel for healing of pressure ulcers.	2-Hydroxypropyl-beta-cyclodextrin	26-57	insulin	Homo sapiens	0-7
25987212-3	2015	Complexation of insulin with hydroxypropyl-beta-cyclodextrin (HPbetaCD) was performed in this work through the coprecipitation method, providing the inclusion complex (HPbetaCD-I).	2-Hydroxypropyl-beta-cyclodextrin	29-60	insulin	Homo sapiens	16-23
25987212-3	2015	Complexation of insulin with hydroxypropyl-beta-cyclodextrin (HPbetaCD) was performed in this work through the coprecipitation method, providing the inclusion complex (HPbetaCD-I).	2-Hydroxypropyl-beta-cyclodextrin	62-70	insulin	Homo sapiens	16-23
25921262-7	2015	2-Hydroxypropyl-beta-cyclodextrin is as effective in reducing Abeta and inflammation in the complement factor H knockout (Cfh(-/-)) mouse that shows advanced ageing and has been proposed as an AMD model.	2-Hydroxypropyl-beta-cyclodextrin	0-33	complement component factor h	Mus musculus	92-111
25944736-5	2015	In this study, we assessed the mechanism of action and therapeutic potential of a new angiogenic molecule, (2-hydroxypropyl)-beta-cyclodextrin (2HP-beta-CD).	2-Hydroxypropyl-beta-cyclodextrin	107-142	beta-carotene oxygenase 1	Mus musculus	148-155
25790376-5	2015	Furthermore, we showed that pharmacological activation of TFEB using 2-hydroxypropyl-beta-cyclodextrin promotes autophagic clearance of aggregated alpha-syn.	2-Hydroxypropyl-beta-cyclodextrin	69-102	synuclein alpha	Homo sapiens	147-156
25107912-7	2014	In addition, based on the loss of Npc2 (Niemann-Pick type C 2) protein expression in the brain, the mice were treated with 2-hydroxypropyl-beta-cyclodextrin, a drug previously reported to rescue Purkinje cell death in a mouse model of Niemann-Pick type C disease.	2-Hydroxypropyl-beta-cyclodextrin	123-156	NPC intracellular cholesterol transporter 2	Mus musculus	34-38
25681338-3	2015	In this study, we reprofiled hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as a vaccine adjuvant and found that it acts as a potent and unique adjuvant.	2-Hydroxypropyl-beta-cyclodextrin	29-60	beta-carotene oxygenase 1	Mus musculus	65-72
24964810-6	2014	Upon direct CNS delivery of HP-beta-CD, we found increases in plasma 24(S)-HC in two independent NPC1 disease animal models, findings that were confirmed in human NPC1 subjects receiving HP-beta-CD.	2-Hydroxypropyl-beta-cyclodextrin	28-38	NPC intracellular cholesterol transporter 1	Homo sapiens	97-101
25115571-6	2014	In Npc1(-/-) mice, treatment with 2HPbetaCD from 49 days reduced whole-liver cholesterol content at 77 days from 33.0 +- 1.0 to 9.1 +- 0.5 mg/organ.	2-Hydroxypropyl-beta-cyclodextrin	34-43	NPC intracellular cholesterol transporter 1	Mus musculus	3-7
25115571-8	2014	There was a transient increase in biliary cholesterol concentration in Npc1(-/-) mice after 2HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	92-101	NPC intracellular cholesterol transporter 1	Mus musculus	71-75
25115571-9	2014	Plasma alanine aminotransferase and aspartate aminotransferase activities in 77-day-old 2HPbetaCD-treated Npc1(-/-) mice were reduced compared with saline-treated controls.	2-Hydroxypropyl-beta-cyclodextrin	88-97	NPC intracellular cholesterol transporter 1	Mus musculus	106-110
25115571-10	2014	The lifespan of Npc1(-/-) mice given 2HPbetaCD marginally exceeded that of the saline-treated controls (99 +- 1.1 vs 94 +- 1.4 days, respectively; P &lt; 0.05).	2-Hydroxypropyl-beta-cyclodextrin	37-46	NPC intracellular cholesterol transporter 1	Mus musculus	16-20
25130438-6	2014	The catalytic efficiency of bovine CYP11A1 for metabolism of L3 dissolved in 2-hydroxypropyl-beta-cyclodextrin was approximately 20% of that reported for vitamin D3 and cholesterol.	2-Hydroxypropyl-beta-cyclodextrin	77-110	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	35-42
25138253-1	2014	The objective of this investigation was to develop a novel cationic polymer, hydroxypropyl-beta-cyclodextrin grafted polyethyleneimine (HP-beta-CD-PEI1800), as a penetration enhancer, and evaluate its viability on improving transdermal delivery of diclofenac sodium.	2-Hydroxypropyl-beta-cyclodextrin	77-108	beta-carotene oxygenase 1	Mus musculus	139-146
24969023-0	2014	A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	124-155	NPC intracellular cholesterol transporter 1	Mus musculus	70-74
25107912-7	2014	In addition, based on the loss of Npc2 (Niemann-Pick type C 2) protein expression in the brain, the mice were treated with 2-hydroxypropyl-beta-cyclodextrin, a drug previously reported to rescue Purkinje cell death in a mouse model of Niemann-Pick type C disease.	2-Hydroxypropyl-beta-cyclodextrin	123-156	NPC intracellular cholesterol transporter 2	Mus musculus	40-61
24907126-7	2014	In addition, we found that hydroxypropyl-beta-cyclodextrin is much more potent and efficacious in the NPC1 neural stem cells compared to the NPC1 fibroblasts.	2-Hydroxypropyl-beta-cyclodextrin	27-58	NPC intracellular cholesterol transporter 1	Homo sapiens	102-106
24868096-6	2014	The LC-MS/MS methods are ~100-fold more sensitive than the current HPLC assay, and were successfully employed to analyze HP-beta-CD in human plasma and CSF samples to support the phase 1 clinical trial of HP-beta-CD in NPC1 patients.	2-Hydroxypropyl-beta-cyclodextrin	205-215	NPC intracellular cholesterol transporter 1	Homo sapiens	219-223
24746691-3	2014	The complexation of Cur and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was done by grinding.	2-Hydroxypropyl-beta-cyclodextrin	28-59	beta-carotene oxygenase 1	Mus musculus	64-71
24459399-4	2014	MATERIALS AND METHODS: The phase solubility of TBE with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was estimated.	2-Hydroxypropyl-beta-cyclodextrin	56-87	beta-carotene oxygenase 1	Mus musculus	92-99
27896072-8	2014	In addition, in vitro analysis showed that the Npc1 gene deficiency and treatment with U18666A, an Npc1 inhibitor, remarkably attenuated the cytotoxicity of HPBCD in Chinese hamster ovary cells.	2-Hydroxypropyl-beta-cyclodextrin	157-162	NPC intracellular cholesterol transporter 1	Cricetulus griseus	47-51
27896072-8	2014	In addition, in vitro analysis showed that the Npc1 gene deficiency and treatment with U18666A, an Npc1 inhibitor, remarkably attenuated the cytotoxicity of HPBCD in Chinese hamster ovary cells.	2-Hydroxypropyl-beta-cyclodextrin	157-162	NPC intracellular cholesterol transporter 1	Cricetulus griseus	99-103
27896072-0	2014	Influence of Npc1 genotype on the toxicity of hydroxypropyl-beta-cyclodextrin, a potentially therapeutic agent, in Niemann-Pick Type C disease models.	2-Hydroxypropyl-beta-cyclodextrin	46-77	NPC intracellular cholesterol transporter 1	Mus musculus	13-17
27896072-4	2014	When treated with HPBCD (20,000 mg/kg, subcutaneously), over half of the wild-type (Npc1+/+) or Npc1+/- mice died by 72 h after the injection.	2-Hydroxypropyl-beta-cyclodextrin	18-23	NPC intracellular cholesterol transporter 1	Mus musculus	84-88
27896072-4	2014	When treated with HPBCD (20,000 mg/kg, subcutaneously), over half of the wild-type (Npc1+/+) or Npc1+/- mice died by 72 h after the injection.	2-Hydroxypropyl-beta-cyclodextrin	18-23	NPC intracellular cholesterol transporter 1	Mus musculus	96-100
24283970-2	2014	This paper describes one of the first TRND programs, the development of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) for the treatment of Niemann-Pick disease type C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	72-105	NPC intracellular cholesterol transporter 1	Homo sapiens	140-168
24283970-2	2014	This paper describes one of the first TRND programs, the development of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) for the treatment of Niemann-Pick disease type C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	72-105	NPC intracellular cholesterol transporter 1	Homo sapiens	170-174
24283970-2	2014	This paper describes one of the first TRND programs, the development of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) for the treatment of Niemann-Pick disease type C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	107-117	NPC intracellular cholesterol transporter 1	Homo sapiens	140-168
24283970-2	2014	This paper describes one of the first TRND programs, the development of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) for the treatment of Niemann-Pick disease type C1 (NPC1).	2-Hydroxypropyl-beta-cyclodextrin	107-117	NPC intracellular cholesterol transporter 1	Homo sapiens	170-174
23943622-5	2013	Both biochemical activity assays and immunoblots of subcellular fractions of sperm incubated with the sterol acceptor 2-hydroxypropyl-beta-cyclodextrin (2-OHCD) confirmed the release of an active PLB fragment.	2-Hydroxypropyl-beta-cyclodextrin	118-151	phospholipase B1	Mus musculus	196-199
24053823-4	2013	We investigated the effects of complexing rhubarb extract with HP-beta-CD on the growth of Huh7 and HepG2 cells by performing cytotoxicity analysis, cellular uptake test, and colony formation assay.	2-Hydroxypropyl-beta-cyclodextrin	63-73	MIR7-3 host gene	Homo sapiens	91-95
23831266-3	2013	(1)H NMR experiments in solution also confirmed the formation of these complexes and demonstrated an insertion of the arsthinol (STB) with its dithiarsolane extremity into the wide rim of the hydroxypropyl-beta-cyclodextrin cavity.	2-Hydroxypropyl-beta-cyclodextrin	192-223	stubby	Mus musculus	129-132
23881911-5	2013	These lipids were modestly decreased following miglustat treatment, but markedly decreased in response to treatment with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), two drugs that have shown efficacy in NPC1 animal models.	2-Hydroxypropyl-beta-cyclodextrin	121-154	NPC intracellular cholesterol transporter 1	Homo sapiens	207-211
23881911-5	2013	These lipids were modestly decreased following miglustat treatment, but markedly decreased in response to treatment with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), two drugs that have shown efficacy in NPC1 animal models.	2-Hydroxypropyl-beta-cyclodextrin	156-166	NPC intracellular cholesterol transporter 1	Homo sapiens	207-211
23881911-9	2013	Similar alterations were observed in the CSF from the NPC1 feline model following HP-beta-CD treatment.	2-Hydroxypropyl-beta-cyclodextrin	82-92	NPC intracellular cholesterol transporter 1	Homo sapiens	54-58
23417986-6	2013	However, when dosed in a solution formulated with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) (15 mg/kg), PTS possessed good bioavailability (F = 59.2 +- 19.6%).	2-Hydroxypropyl-beta-cyclodextrin	50-83	6-pyruvoyl-tetrahydropterin synthase	Rattus norvegicus	109-112
24065164-1	2013	Pseudopterosin A (PsA) treatment of growth factor depleted human umbilical vein endothelial cell (HUVEC) cultures formulated in hydroxypropyl-beta-cyclodextrin (HPbetaCD) for 42 h unexpectedly produced a 25% increase in cell proliferation (EC50 = 1.34 x 10-8 M).	2-Hydroxypropyl-beta-cyclodextrin	128-159	aminopeptidase puromycin sensitive	Homo sapiens	18-21
24065164-3	2013	The formulation of PsA into HPbetaCD produced a 200-fold increase in potency over a DMSO formulation; we propose this could result from a constrained presentation of PsA to the receptor, which would limit non-specific binding.	2-Hydroxypropyl-beta-cyclodextrin	28-36	aminopeptidase puromycin sensitive	Homo sapiens	19-22
24065164-3	2013	The formulation of PsA into HPbetaCD produced a 200-fold increase in potency over a DMSO formulation; we propose this could result from a constrained presentation of PsA to the receptor, which would limit non-specific binding.	2-Hydroxypropyl-beta-cyclodextrin	28-36	aminopeptidase puromycin sensitive	Homo sapiens	166-169
23417986-10	2013	CONCLUSION: Aqueous solubility was identified as a barrier to its oral bioavailability while solubilizing PTS with HP-beta-CD substantially increased its bioavailability; dose manipulation was a practical strategy to enhance its bioavailability and systemic exposure; and its delivery through oral mucosa was feasible.	2-Hydroxypropyl-beta-cyclodextrin	115-125	6-pyruvoyl-tetrahydropterin synthase	Rattus norvegicus	106-109
23417986-6	2013	However, when dosed in a solution formulated with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) (15 mg/kg), PTS possessed good bioavailability (F = 59.2 +- 19.6%).	2-Hydroxypropyl-beta-cyclodextrin	85-95	6-pyruvoyl-tetrahydropterin synthase	Rattus norvegicus	109-112
22892156-1	2012	An injection of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) to mice lacking Niemann Pick type C (NPC) protein results in delayed neurodegeneration, decreased inflammation, and prolonged lifespan.	2-Hydroxypropyl-beta-cyclodextrin	16-49	beta-carotene oxygenase 1	Mus musculus	54-61
23192786-8	2013	HPbetaCD-based formulation dramatically improved antiallodynic effect of MDA7 in comparison with the liposomes preparation.	2-Hydroxypropyl-beta-cyclodextrin	0-8	interleukin 24	Rattus norvegicus	73-77
23215690-0	2013	2-Hydroxypropyl-beta-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells.	2-Hydroxypropyl-beta-cyclodextrin	0-33	sarcolipin	Homo sapiens	43-46
23215690-0	2013	2-Hydroxypropyl-beta-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells.	2-Hydroxypropyl-beta-cyclodextrin	0-33	ATP binding cassette subfamily B member 1	Homo sapiens	76-90
22415157-2	2012	A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (alpha, beta, MebetaCD and HPbetaCD) covalently linked through a phosphodiester bridge to different labels, in highly pure form and under very mild detachment conditions.	2-Hydroxypropyl-beta-cyclodextrin	112-120	complement C6	Homo sapiens	58-61
22318938-4	2012	We report here cytotoxic effects of a novel OA-rich triterpene extract from mistletoe (V. album L., Santalaceae) solubilized by 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) on B16.F10 mouse melanoma cells.	2-Hydroxypropyl-beta-cyclodextrin	128-161	beta-carotene oxygenase 1	Mus musculus	168-175
22619379-10	2012	Expression of Lgals3 and Ctsd was normalized following treatment with 2-hydroxypropyl-beta-cyclodextrin, a therapy that reduces pathological findings and significantly increases Npc1(-/-) survival.	2-Hydroxypropyl-beta-cyclodextrin	70-103	lectin, galactose binding, soluble 3	Mus musculus	14-20
22619379-10	2012	Expression of Lgals3 and Ctsd was normalized following treatment with 2-hydroxypropyl-beta-cyclodextrin, a therapy that reduces pathological findings and significantly increases Npc1(-/-) survival.	2-Hydroxypropyl-beta-cyclodextrin	70-103	cathepsin D	Mus musculus	25-29
22619379-10	2012	Expression of Lgals3 and Ctsd was normalized following treatment with 2-hydroxypropyl-beta-cyclodextrin, a therapy that reduces pathological findings and significantly increases Npc1(-/-) survival.	2-Hydroxypropyl-beta-cyclodextrin	70-103	NPC intracellular cholesterol transporter 1	Mus musculus	178-182
22876616-5	2012	HPCD improved the solubility of CIP 3 times at pH 5.5 and 2 times at pH 7.4.	2-Hydroxypropyl-beta-cyclodextrin	0-4	exosome component 8	Homo sapiens	32-37
22466854-7	2012	It was concluded that the HP-beta-CD caused specific conformational changes in SOD by non-covalent modification.	2-Hydroxypropyl-beta-cyclodextrin	26-36	superoxide dismutase 1	Homo sapiens	79-82
22377264-6	2012	The influence of alpha-crystallin and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on aggregation of UV-irradiated GAPDH was studied.	2-Hydroxypropyl-beta-cyclodextrin	38-71	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	117-122
22377264-6	2012	The influence of alpha-crystallin and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on aggregation of UV-irradiated GAPDH was studied.	2-Hydroxypropyl-beta-cyclodextrin	73-83	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	117-122
22377264-7	2012	Despite the fact that HP-beta-CD accelerates thermal aggregation of non-irradiated GAPDH, in the case of aggregation of UV-irradiated GAPDH HP-beta-CD reveals a purely protective effect.	2-Hydroxypropyl-beta-cyclodextrin	22-32	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	83-88
22377264-7	2012	Despite the fact that HP-beta-CD accelerates thermal aggregation of non-irradiated GAPDH, in the case of aggregation of UV-irradiated GAPDH HP-beta-CD reveals a purely protective effect.	2-Hydroxypropyl-beta-cyclodextrin	140-150	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	134-139
21645594-1	2011	The aim of this study was to evaluate the safety and anti-tumor effect of 9-nitro-camptothecin/hydroxypropyl-beta-cyclodextrin (9-NC/HP-beta-CD) complex on tumor-bearing mice.	2-Hydroxypropyl-beta-cyclodextrin	95-126	beta-carotene oxygenase 1	Mus musculus	136-143
22037294-2	2012	The assay involves derivatization with FITC followed by CE-LIF using 0.5 mM hydroxyl propyl-beta-cyclodextrin in borate buffer [80 mM, pH 9.3].	2-Hydroxypropyl-beta-cyclodextrin	76-109	LIF interleukin 6 family cytokine	Homo sapiens	59-62
22689424-1	2012	Natural borneol (NB)/2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) inclusion complex has been prepared, and characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FT-IR).	2-Hydroxypropyl-beta-cyclodextrin	21-54	beta-carotene oxygenase 1	Mus musculus	59-66
21525004-6	2011	Application of 2-hydroxypropyl-beta-cyclodextrin (a sterol-binding agent) or overexpression of Rab9 rescued the progesterone-induced HERG trafficking defect and ER stress.	2-Hydroxypropyl-beta-cyclodextrin	15-48	potassium voltage-gated channel subfamily H member 2	Homo sapiens	133-137
21094690-11	2011	Furthermore, we used the laser-ablation technique to generate BPIB aqueous solution in the presence of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) without the use of hazardous dimethyl sulfoxide (DMSO).	2-Hydroxypropyl-beta-cyclodextrin	103-136	beta-carotene oxygenase 1	Mus musculus	141-148
21697390-4	2011	When injected into the CNS of the npc1(-/-) mouse, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a compound known to prevent this C accumulation, diffused throughout the brain and was excreted with a t(&frac12;) of 6.5 h. This agent caused suppression of C synthesis, elevation of C esters, suppression of sterol regulatory-binding protein 2 (SREBP2) target genes, and activation of liver X receptor-controlled genes.	2-Hydroxypropyl-beta-cyclodextrin	51-84	NPC intracellular cholesterol transporter 1	Mus musculus	34-38
21697390-4	2011	When injected into the CNS of the npc1(-/-) mouse, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a compound known to prevent this C accumulation, diffused throughout the brain and was excreted with a t(&frac12;) of 6.5 h. This agent caused suppression of C synthesis, elevation of C esters, suppression of sterol regulatory-binding protein 2 (SREBP2) target genes, and activation of liver X receptor-controlled genes.	2-Hydroxypropyl-beta-cyclodextrin	51-84	adrenocortical dysplasia	Mus musculus	89-96
21697390-4	2011	When injected into the CNS of the npc1(-/-) mouse, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a compound known to prevent this C accumulation, diffused throughout the brain and was excreted with a t(&frac12;) of 6.5 h. This agent caused suppression of C synthesis, elevation of C esters, suppression of sterol regulatory-binding protein 2 (SREBP2) target genes, and activation of liver X receptor-controlled genes.	2-Hydroxypropyl-beta-cyclodextrin	51-84	sterol regulatory element binding factor 2	Mus musculus	345-351
21459030-7	2011	Treatment of Npc1(-/-) mice with hydroxypropyl-beta-cyclodextrin (HPBCD), despite efficacious effects in brain and liver, results in little difference from age-matched controls (using a CNS-expressed transgene to extend the life expectancy of the Npc1(-/-) mice) for these variables.	2-Hydroxypropyl-beta-cyclodextrin	33-64	NPC intracellular cholesterol transporter 1	Mus musculus	13-17
21459030-7	2011	Treatment of Npc1(-/-) mice with hydroxypropyl-beta-cyclodextrin (HPBCD), despite efficacious effects in brain and liver, results in little difference from age-matched controls (using a CNS-expressed transgene to extend the life expectancy of the Npc1(-/-) mice) for these variables.	2-Hydroxypropyl-beta-cyclodextrin	33-64	NPC intracellular cholesterol transporter 1	Mus musculus	247-251
21193873-11	2010	The (1)H NMR studies revealed the binding of (99m)Tc at C-8/H-8 position of HPbetaCD.	2-Hydroxypropyl-beta-cyclodextrin	76-84	homeobox C8	Homo sapiens	56-59
20970221-0	2010	2-Hydroxypropyl-beta-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.	2-Hydroxypropyl-beta-cyclodextrin	0-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	131-134
20970221-0	2010	2-Hydroxypropyl-beta-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.	2-Hydroxypropyl-beta-cyclodextrin	0-33	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	135-138
22178947-1	2011	The effects of (2-hydroxypropyl)-beta-cyclodextrin (HPbetaCD), a cyclic oligomer, on membrane electroporation-induced inward current (I(MEP)) in pituitary tumor (GH(3)) cells were experimentally and analytically characterized.	2-Hydroxypropyl-beta-cyclodextrin	15-50	neurolysin	Rattus norvegicus	136-139
22178947-1	2011	The effects of (2-hydroxypropyl)-beta-cyclodextrin (HPbetaCD), a cyclic oligomer, on membrane electroporation-induced inward current (I(MEP)) in pituitary tumor (GH(3)) cells were experimentally and analytically characterized.	2-Hydroxypropyl-beta-cyclodextrin	52-60	neurolysin	Rattus norvegicus	136-139
22178947-6	2011	However, in HPbetaCD-treated cells, the ability of AAPH to enhance I(MEP) was abolished.	2-Hydroxypropyl-beta-cyclodextrin	12-20	neurolysin	Rattus norvegicus	69-72
22178947-9	2011	The energy change of I(MEP) in untreated and HPbetaCD-treated cells was estimated to be -17.7 and -44.8 kJ/mol, respectively, and the perturbation of free energy following HPbetaCD treatment was -27.1 kJ/mol.	2-Hydroxypropyl-beta-cyclodextrin	45-53	neurolysin	Rattus norvegicus	23-26
22178947-9	2011	The energy change of I(MEP) in untreated and HPbetaCD-treated cells was estimated to be -17.7 and -44.8 kJ/mol, respectively, and the perturbation of free energy following HPbetaCD treatment was -27.1 kJ/mol.	2-Hydroxypropyl-beta-cyclodextrin	172-180	neurolysin	Rattus norvegicus	23-26
22178947-12	2011	Taken together, depletion of membrane cholesterol by HPbetaCD can elevate the edge energy of pore formation, thereby decreasing the I(MEP) magnitude.	2-Hydroxypropyl-beta-cyclodextrin	53-61	neurolysin	Rattus norvegicus	134-137
20540152-0	2010	Effect of 2-hydroxypropyl-beta-cyclodextrin on thermal stability and aggregation of glycogen phosphorylase b from rabbit skeletal muscle.	2-Hydroxypropyl-beta-cyclodextrin	10-43	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	84-108
20540152-1	2010	The study of the kinetics of thermal aggregation of glycogen phosphorylase b (Phb) from rabbit skeletal muscles by dynamic light scattering at 48 C showed that 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) accelerated the aggregation process and induced the formation of the larger protein aggregates.	2-Hydroxypropyl-beta-cyclodextrin	160-193	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	52-76
20540152-1	2010	The study of the kinetics of thermal aggregation of glycogen phosphorylase b (Phb) from rabbit skeletal muscles by dynamic light scattering at 48 C showed that 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) accelerated the aggregation process and induced the formation of the larger protein aggregates.	2-Hydroxypropyl-beta-cyclodextrin	195-205	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	52-76
21193873-13	2010	Docking studies demonstrated the interaction between HPbetaCD and bacterial maltose binding protein (MBP).	2-Hydroxypropyl-beta-cyclodextrin	53-61	myelin basic protein	Homo sapiens	76-99
21193873-13	2010	Docking studies demonstrated the interaction between HPbetaCD and bacterial maltose binding protein (MBP).	2-Hydroxypropyl-beta-cyclodextrin	53-61	myelin basic protein	Homo sapiens	101-104
19750228-5	2009	METHODOLOGY/PRINCIPAL FINDINGS: Administration of CD to Npc1(-/-) mice beginning at either P7 or P21 and continuing every other day delayed clinical onset, reduced intraneuronal cholesterol and GSL storage as well as free sphingosine accumulation, reduced markers of neurodegeneration, and led to longer survival than any previous treatment regime.	2-Hydroxypropyl-beta-cyclodextrin	50-52	NPC intracellular cholesterol transporter 1	Mus musculus	56-60
20337728-8	2010	Addition of HPbetaCD in the poloxamer formulation particularly reversed levels of systemic and local levels of TNFalpha and KC.	2-Hydroxypropyl-beta-cyclodextrin	12-20	tumor necrosis factor	Mus musculus	111-119
20212119-2	2010	Recent studies have shown that hydroxypropyl-beta-cyclodextrin injections in npc1(-/-) mice are partially effective in treating this disease.	2-Hydroxypropyl-beta-cyclodextrin	31-62	NPC intracellular cholesterol transporter 1	Mus musculus	77-81
20357695-1	2010	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) is a promising experimental therapy for Niemann-Pick type C disease that improved intracellular cholesterol transport, substantially reduced neurodegeneration and hepatic disease, and increased lifespan in npc1 mice.	2-Hydroxypropyl-beta-cyclodextrin	0-33	NPC intracellular cholesterol transporter 1	Mus musculus	251-255
20357695-1	2010	2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) is a promising experimental therapy for Niemann-Pick type C disease that improved intracellular cholesterol transport, substantially reduced neurodegeneration and hepatic disease, and increased lifespan in npc1 mice.	2-Hydroxypropyl-beta-cyclodextrin	35-43	NPC intracellular cholesterol transporter 1	Mus musculus	251-255
20338194-0	2010	Effect of 2-hydroxypropyl-beta-cyclodextrin on thermal inactivation, denaturation and aggregation of glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle.	2-Hydroxypropyl-beta-cyclodextrin	10-43	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	101-141
20338194-1	2010	The effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal aggregation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle at 45 degrees C has been studied using dynamic light scattering.	2-Hydroxypropyl-beta-cyclodextrin	14-47	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	87-127
20338194-1	2010	The effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal aggregation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle at 45 degrees C has been studied using dynamic light scattering.	2-Hydroxypropyl-beta-cyclodextrin	14-47	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	129-134
20338194-1	2010	The effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal aggregation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle at 45 degrees C has been studied using dynamic light scattering.	2-Hydroxypropyl-beta-cyclodextrin	49-59	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	87-127
20338194-1	2010	The effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal aggregation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle at 45 degrees C has been studied using dynamic light scattering.	2-Hydroxypropyl-beta-cyclodextrin	49-59	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	129-134
20338194-3	2010	The acceleration of GAPDH aggregation was due to destabilization of the enzyme molecule under the action of HP-beta-CD.	2-Hydroxypropyl-beta-cyclodextrin	108-118	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	20-25
19965601-2	2010	Acute administration of 2-hydroxypropyl-beta-cyclodextrin (CYCLO) rapidly overcomes this transport defect in both the 7-day-old pup and 49-day-old mature npc1(-/-) mouse, even though this compound is cleared from the body and plasma six times faster in the mature mouse than in the neonatal animal.	2-Hydroxypropyl-beta-cyclodextrin	24-57	NPC intracellular cholesterol transporter 1	Mus musculus	154-158
19965601-2	2010	Acute administration of 2-hydroxypropyl-beta-cyclodextrin (CYCLO) rapidly overcomes this transport defect in both the 7-day-old pup and 49-day-old mature npc1(-/-) mouse, even though this compound is cleared from the body and plasma six times faster in the mature mouse than in the neonatal animal.	2-Hydroxypropyl-beta-cyclodextrin	59-64	NPC intracellular cholesterol transporter 1	Mus musculus	154-158
19965601-8	2010	These studies demonstrate that CYCLO administration acutely reverses the cholesterol transport defect seen in the NPC1 mouse at any age, and this reversal allows the sequestered sterol to be excreted from the body as bile acid.	2-Hydroxypropyl-beta-cyclodextrin	31-36	NPC intracellular cholesterol transporter 1	Mus musculus	114-118
19884502-6	2009	The NPC1 or NPC2 block in cholesterol delivery to the ER can be overcome by 2-hydroxypropyl-beta-cyclodextrin, which leads to a marked increase in ACAT-mediated cholesterol esterification.	2-Hydroxypropyl-beta-cyclodextrin	76-109	NPC intracellular cholesterol transporter 1	Homo sapiens	4-8
19884502-6	2009	The NPC1 or NPC2 block in cholesterol delivery to the ER can be overcome by 2-hydroxypropyl-beta-cyclodextrin, which leads to a marked increase in ACAT-mediated cholesterol esterification.	2-Hydroxypropyl-beta-cyclodextrin	76-109	NPC intracellular cholesterol transporter 2	Homo sapiens	12-16
19884502-6	2009	The NPC1 or NPC2 block in cholesterol delivery to the ER can be overcome by 2-hydroxypropyl-beta-cyclodextrin, which leads to a marked increase in ACAT-mediated cholesterol esterification.	2-Hydroxypropyl-beta-cyclodextrin	76-109	sterol O-acyltransferase 1	Homo sapiens	147-151
19750228-8	2009	CONCLUSIONS/SIGNIFICANCE: Treatment with CD delayed clinical disease onset, reduced intraneuronal storage and secondary markers of neurodegeneration, and significantly increased lifespan of both Npc1(-/-) and Npc2(-/-) mice.	2-Hydroxypropyl-beta-cyclodextrin	41-43	NPC intracellular cholesterol transporter 2	Mus musculus	209-213
19750228-8	2009	CONCLUSIONS/SIGNIFICANCE: Treatment with CD delayed clinical disease onset, reduced intraneuronal storage and secondary markers of neurodegeneration, and significantly increased lifespan of both Npc1(-/-) and Npc2(-/-) mice.	2-Hydroxypropyl-beta-cyclodextrin	41-43	NPC intracellular cholesterol transporter 1	Mus musculus	195-199
18036789-2	2008	This study focuses on the development and pharmacological evaluation of a RVC in 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) inclusion complex.	2-Hydroxypropyl-beta-cyclodextrin	81-114	beta-carotene oxygenase 1	Mus musculus	119-126
19564937-0	2009	Effects of hydroxylpropyl-beta-cyclodextrin on in vitro insulin stability.	2-Hydroxypropyl-beta-cyclodextrin	11-43	insulin	Homo sapiens	56-63
19564937-1	2009	The objective of this study was to elucidate the effects of hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) on the in vitro stability of insulin.	2-Hydroxypropyl-beta-cyclodextrin	60-92	insulin	Homo sapiens	135-142
19564937-1	2009	The objective of this study was to elucidate the effects of hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) on the in vitro stability of insulin.	2-Hydroxypropyl-beta-cyclodextrin	94-104	insulin	Homo sapiens	135-142
19564937-2	2009	It was found that HP-beta-CD had positive effects on the stability of insulin in acid and base and under high temperature conditions.	2-Hydroxypropyl-beta-cyclodextrin	18-28	insulin	Homo sapiens	70-77
19564937-3	2009	Furthermore, use of HP-beta-CD could also increase the stability of disulfide bonds which are important to the conformation of insulin.	2-Hydroxypropyl-beta-cyclodextrin	20-30	insulin	Homo sapiens	127-134
19564937-4	2009	Through (1)H-NMR experiments it was found that the protective effect of HP-beta-CD was due to complexation with insulin.	2-Hydroxypropyl-beta-cyclodextrin	72-82	insulin	Homo sapiens	112-119
19564937-5	2009	The results suggest that the presence of HP-beta-CD could improve the stability of insulin in different environments.	2-Hydroxypropyl-beta-cyclodextrin	41-51	insulin	Homo sapiens	83-90
19179626-7	2009	On the other hand, depletion of cholesterol content by hydroxypropyl-beta-cyclodextrin upregulated PCSK9 transcripts (20%, P&lt;0.05) and protein mass (540%, P&lt;0.001), in parallel with SREBP-2 protein levels.	2-Hydroxypropyl-beta-cyclodextrin	55-86	proprotein convertase subtilisin/kexin type 9	Homo sapiens	99-104
19179626-7	2009	On the other hand, depletion of cholesterol content by hydroxypropyl-beta-cyclodextrin upregulated PCSK9 transcripts (20%, P&lt;0.05) and protein mass (540%, P&lt;0.001), in parallel with SREBP-2 protein levels.	2-Hydroxypropyl-beta-cyclodextrin	55-86	sterol regulatory element binding transcription factor 2	Homo sapiens	188-195
19330082-4	2008	In addition, it was found that the complexation of insulin with HP-beta-CD was characterized by UV absorption spectra.	2-Hydroxypropyl-beta-cyclodextrin	64-74	insulin	Homo sapiens	51-58
19330082-5	2008	These results indicated that HP-beta-CD, casein and protamine could offer some positive and useful results, and could protect insulin from degradation during their transit through the intestinal tract.	2-Hydroxypropyl-beta-cyclodextrin	29-39	insulin	Homo sapiens	126-133
19118040-1	2009	PURPOSE: beta-Lapachone (ARQ 501, a formulation of beta-lapachone complexed with hydroxypropyl-beta-cyclodextrin) is a novel anticancer agent with selectivity against prostate cancer cells overexpressing the NAD(P)H:quinone oxidoreductase-1 enzyme.	2-Hydroxypropyl-beta-cyclodextrin	81-112	NAD(P)H dehydrogenase, quinone 1	Mus musculus	208-240
17554422-5	2007	The amounts of PAHs degraded by the catabolic activity of the indigenous microflora in each of the soils were correlated with HPCD-extractable PAH concentrations.	2-Hydroxypropyl-beta-cyclodextrin	126-130	phenylalanine hydroxylase	Homo sapiens	15-18
17631110-1	2007	The fluorescence spectral behavior of interaction of erythrosine sodium (ES) and bovine serum albumin (BSA) was investigated in hydroxypropyl-beta-cyclodextrin (HP-beta-CD) medium at pH 5.8.	2-Hydroxypropyl-beta-cyclodextrin	161-171	albumin	Homo sapiens	88-101
17513944-0	2007	Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay.	2-Hydroxypropyl-beta-cyclodextrin	0-32	ETS transcription factor ERG	Homo sapiens	72-76
15240128-4	2004	By measuring fluorescence and flow cytometry using the fluorescence dyes 1,6-diphenyl-1,3,5-hexatriene and Merocyanine 540, we found that overexpressing caveolin-1 resulted in a similar increase in membrane fluidity and loosening of lipid packing density as cholesterol depletion by 1 mM methyl-beta-cyclodextrin (MbetaCD) or 2-hydroxypropyl-beta-cyclodextrin (HbetaCD).	2-Hydroxypropyl-beta-cyclodextrin	326-359	caveolin 1	Homo sapiens	153-163
17050774-6	2006	Similar to the regulation of the increase in tyrosine phosphorylation, cholesterol acceptors such as bovine serum albumin (BSA) or 2-hydroxypropyl-beta-cyclodextrin (2-OH-propyl-beta-CD) were essential for the regulation of proline-directed phosphorylation in mouse sperm.	2-Hydroxypropyl-beta-cyclodextrin	131-164	beta-carotene oxygenase 1	Mus musculus	178-185
16564118-4	2006	The efficacy of the HPCD-extraction technique for the estimation of PAH microbial availability in soil is demonstrated in the presence of co-contaminants that have been aged for the duration of the experiment together in the soil.	2-Hydroxypropyl-beta-cyclodextrin	20-24	phenylalanine hydroxylase	Homo sapiens	68-71
16564118-6	2006	Overall, a single HPCD-extraction technique proved accurate and reproducible for the estimation of PAH bioavailability from soil.	2-Hydroxypropyl-beta-cyclodextrin	18-22	phenylalanine hydroxylase	Homo sapiens	99-102
16883563-9	2006	beta-Lap complexation with hydroxypropyl-beta-cyclodextrin (HPbeta-CD) prevented drug dissolution in PLGA, and led to fast release (79.6+/-2.1% after 2 days).	2-Hydroxypropyl-beta-cyclodextrin	27-58	LAP	Homo sapiens	5-8
16795019-7	2006	These results suggest that bile acids have a pivotal role for bioavailability of FPFS-410 after oral administration of the FPFS-410 complex with HP-beta-CyD through CYP3A2 activity in liver of rats.	2-Hydroxypropyl-beta-cyclodextrin	145-156	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	165-171
17184939-10	2007	Among the additives, hydroxypropyl-gamma-cyclodextrin and hydroxy propyl-beta-cyclodextrin protected PAL against emulsion mediated loss in activity.	2-Hydroxypropyl-beta-cyclodextrin	58-90	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	101-104
16117107-9	2005	However, the AC2 soil showed a more modest correlation between the biodegradable fraction and the HPCD extractable fraction, with the HPCD extraction slightly underestimating the extent of PAH biodegradation.	2-Hydroxypropyl-beta-cyclodextrin	98-102	adenylate cyclase 2	Homo sapiens	13-16
15653135-5	2005	FTIR spectra of dried microspheres containing HPbetaCD showed a change in insulin secondary structure, attributed to the presence of insulin/HPbetaCD complexes within microspheres.	2-Hydroxypropyl-beta-cyclodextrin	46-54	insulin	Homo sapiens	74-81
15653135-5	2005	FTIR spectra of dried microspheres containing HPbetaCD showed a change in insulin secondary structure, attributed to the presence of insulin/HPbetaCD complexes within microspheres.	2-Hydroxypropyl-beta-cyclodextrin	46-54	insulin	Homo sapiens	133-140
15653135-5	2005	FTIR spectra of dried microspheres containing HPbetaCD showed a change in insulin secondary structure, attributed to the presence of insulin/HPbetaCD complexes within microspheres.	2-Hydroxypropyl-beta-cyclodextrin	141-149	insulin	Homo sapiens	74-81
15653135-6	2005	Insulin release was affected by the presence of HPbetaCD depending on the initial formulation conditions.	2-Hydroxypropyl-beta-cyclodextrin	48-56	insulin	Homo sapiens	0-7
15653135-8	2005	Combining the release kinetics of HPbetaCD with the FTIR results on hydrated microspheres, it was concluded that the formation of insulin/HPbetaCD complexes inside microspheres is critical to decrease protein diffusivity in the polymer matrix and achieve an effective modulation of protein release rate.	2-Hydroxypropyl-beta-cyclodextrin	34-42	insulin	Homo sapiens	130-137
15653135-8	2005	Combining the release kinetics of HPbetaCD with the FTIR results on hydrated microspheres, it was concluded that the formation of insulin/HPbetaCD complexes inside microspheres is critical to decrease protein diffusivity in the polymer matrix and achieve an effective modulation of protein release rate.	2-Hydroxypropyl-beta-cyclodextrin	138-146	insulin	Homo sapiens	130-137
15240128-4	2004	By measuring fluorescence and flow cytometry using the fluorescence dyes 1,6-diphenyl-1,3,5-hexatriene and Merocyanine 540, we found that overexpressing caveolin-1 resulted in a similar increase in membrane fluidity and loosening of lipid packing density as cholesterol depletion by 1 mM methyl-beta-cyclodextrin (MbetaCD) or 2-hydroxypropyl-beta-cyclodextrin (HbetaCD).	2-Hydroxypropyl-beta-cyclodextrin	361-368	caveolin 1	Homo sapiens	153-163
15240128-5	2004	Moreover, we found that the transport activity of P-gp was significantly inhibited by 1 mM MbetaCD or HbetaCD, which is also similar to the inhibitory effect of caveolin-1 overexpression.	2-Hydroxypropyl-beta-cyclodextrin	102-109	phosphoglycolate phosphatase	Homo sapiens	50-54
15240128-5	2004	Moreover, we found that the transport activity of P-gp was significantly inhibited by 1 mM MbetaCD or HbetaCD, which is also similar to the inhibitory effect of caveolin-1 overexpression.	2-Hydroxypropyl-beta-cyclodextrin	102-109	caveolin 1	Homo sapiens	161-171
11878189-9	2002	The half-life of [Leu2]-TRH-CDS/HPBCD solid complex at 25 degrees C, 4 degrees C and -15 degrees C was about 100 days, 440 days and no detectable change in three months, respectively.	2-Hydroxypropyl-beta-cyclodextrin	32-37	thyrotropin releasing hormone	Mus musculus	24-27
12036855-4	2002	We found that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta (MIP-1 beta) using CCR5-expressing CEM-NKR T cells.	2-Hydroxypropyl-beta-cyclodextrin	40-71	C-C motif chemokine ligand 4	Homo sapiens	129-167
12036855-4	2002	We found that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta (MIP-1 beta) using CCR5-expressing CEM-NKR T cells.	2-Hydroxypropyl-beta-cyclodextrin	40-71	C-C motif chemokine ligand 4	Homo sapiens	169-179
12036855-4	2002	We found that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta (MIP-1 beta) using CCR5-expressing CEM-NKR T cells.	2-Hydroxypropyl-beta-cyclodextrin	40-71	C-C motif chemokine receptor 5	Homo sapiens	187-191
12403054-4	2002	The administration of entacapone as a solution (plain solution pH 7.4; F=34.8% or entacapone/HP-beta-CD solution pH 3.0; F = 18.5%) resulted in significantly higher degree of COMT inhibition in erythrocytes than could be achieved by administering entacapone as a suspension (pH 3.0; F=8.9%).	2-Hydroxypropyl-beta-cyclodextrin	93-103	catechol-O-methyltransferase	Rattus norvegicus	175-179
11937572-2	2002	To elucidate a possible mechanism, we determined that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) inhibits stromal cell-derived factor 1alpha (SDF-1alpha) binding to CXCR4 on T cell lines and PBMCs.	2-Hydroxypropyl-beta-cyclodextrin	80-111	C-X-C motif chemokine receptor 4	Homo sapiens	186-191
11878189-0	2002	Effect of 2-hydroxypropyl-beta-cyclodextrin on the solubility, stability, and pharmacological activity of the chemical delivery system of TRH analogs.	2-Hydroxypropyl-beta-cyclodextrin	10-43	thyrotropin releasing hormone	Mus musculus	138-141
11878189-1	2002	To improve the aqueous solubility and stability of the chemical delivery system (CDS) of the thyrotropin-releasing hormone (TRH) analogs, 2-hydroxypropyl-beta-cyclodextrin (HPBCD) has been attempted.	2-Hydroxypropyl-beta-cyclodextrin	138-171	thyrotropin releasing hormone	Mus musculus	93-122
11878189-1	2002	To improve the aqueous solubility and stability of the chemical delivery system (CDS) of the thyrotropin-releasing hormone (TRH) analogs, 2-hydroxypropyl-beta-cyclodextrin (HPBCD) has been attempted.	2-Hydroxypropyl-beta-cyclodextrin	138-171	thyrotropin releasing hormone	Mus musculus	124-127
15290851-8	2004	Transport studies using 16HBE14o(-) cells demonstrated that the increase in the permeability of enoxaparin and mannitol, reduction in TEER, and the changes in the tight junction protein ZO-1 distribution produced by 5% DMbetaCD were much greater than those produced by beta-cyclodextrin (betaCD) or hydroxyl-propyl-beta-cyclodextrin (HPbetaCD).	2-Hydroxypropyl-beta-cyclodextrin	334-342	tight junction protein 1	Homo sapiens	186-190
15147805-5	2004	Integrating hydroxypropyl-beta-cyclodextrin (HP-beta-CD) into the matrices proved to stabilise IFN-alpha and led to a higher and faster protein release due to solubilising effects.	2-Hydroxypropyl-beta-cyclodextrin	12-43	interferon alpha 1	Homo sapiens	95-104
15147805-5	2004	Integrating hydroxypropyl-beta-cyclodextrin (HP-beta-CD) into the matrices proved to stabilise IFN-alpha and led to a higher and faster protein release due to solubilising effects.	2-Hydroxypropyl-beta-cyclodextrin	45-55	interferon alpha 1	Homo sapiens	95-104
12593932-0	2003	Mechanistic studies of the effect of hydroxypropyl-beta-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin.	2-Hydroxypropyl-beta-cyclodextrin	37-68	lysine demethylase and nuclear receptor corepressor	Mus musculus	130-138
12526823-10	2003	The co-encapsulation of HPbetaCD slowed down the overall release rate and, in the case of microspheres prepared from the emulsion, allowed a constant insulin release up to 45 days.	2-Hydroxypropyl-beta-cyclodextrin	24-32	insulin	Bos taurus	150-157
12526823-13	2003	Additives with complexing properties such as HPbetaCD have demonstrated a potential in optimizing the release rate of insulin when used in microspheres prepared from W/O emulsions.	2-Hydroxypropyl-beta-cyclodextrin	45-53	insulin	Bos taurus	118-125
12069165-5	2002	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increased lysozyme recovery from 35% to 70% at low lysozyme concentration (20 mg/ml), and from 70% to 77% at high lysozyme concentration (100 mg/ml) in the presence of PLGA.	2-Hydroxypropyl-beta-cyclodextrin	0-31	lysozyme	Homo sapiens	55-63
12069165-5	2002	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increased lysozyme recovery from 35% to 70% at low lysozyme concentration (20 mg/ml), and from 70% to 77% at high lysozyme concentration (100 mg/ml) in the presence of PLGA.	2-Hydroxypropyl-beta-cyclodextrin	0-31	lysozyme	Homo sapiens	96-104
12069165-5	2002	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increased lysozyme recovery from 35% to 70% at low lysozyme concentration (20 mg/ml), and from 70% to 77% at high lysozyme concentration (100 mg/ml) in the presence of PLGA.	2-Hydroxypropyl-beta-cyclodextrin	0-31	lysozyme	Homo sapiens	96-104
12069165-5	2002	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increased lysozyme recovery from 35% to 70% at low lysozyme concentration (20 mg/ml), and from 70% to 77% at high lysozyme concentration (100 mg/ml) in the presence of PLGA.	2-Hydroxypropyl-beta-cyclodextrin	33-43	lysozyme	Homo sapiens	55-63
12069165-5	2002	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increased lysozyme recovery from 35% to 70% at low lysozyme concentration (20 mg/ml), and from 70% to 77% at high lysozyme concentration (100 mg/ml) in the presence of PLGA.	2-Hydroxypropyl-beta-cyclodextrin	33-43	lysozyme	Homo sapiens	96-104
12069165-5	2002	Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increased lysozyme recovery from 35% to 70% at low lysozyme concentration (20 mg/ml), and from 70% to 77% at high lysozyme concentration (100 mg/ml) in the presence of PLGA.	2-Hydroxypropyl-beta-cyclodextrin	33-43	lysozyme	Homo sapiens	96-104
12069165-8	2002	CONCLUSIONS: HP-beta-CD was found to be a promising stabilizer that protected lysozyme during the primary emulsification.	2-Hydroxypropyl-beta-cyclodextrin	13-23	lysozyme	Homo sapiens	78-86
11878189-7	2002	In pH 6.5 and 7.4 HPBCD solution, the degradation of CDS was mainly via acid catalyzed water addition reaction, thus, e.g. [Leu2]-TRH-CDS was more stable in pH 7.4 than in pH 6.5 aqueous solutions.	2-Hydroxypropyl-beta-cyclodextrin	18-23	thyrotropin releasing hormone	Mus musculus	130-133
11878189-11	2002	Dimethyl sulfoxide although increased the solubility of [Leu2]-TRH-CDS in the 50% HPBCD solution by 1.3 times, significantly decreased its stability by 6.6 times.	2-Hydroxypropyl-beta-cyclodextrin	82-87	thyrotropin releasing hormone	Mus musculus	63-66
11775960-0	2001	Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsin.	2-Hydroxypropyl-beta-cyclodextrin	55-87	transient receptor potential cation channel subfamily C member 6	Homo sapiens	18-22
11775960-0	2001	Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsin.	2-Hydroxypropyl-beta-cyclodextrin	89-97	transient receptor potential cation channel subfamily C member 6	Homo sapiens	18-22
11775960-1	2001	PURPOSE: The purpose of this study is to investigate the mechanisms and thermodynamics of the interaction between hydroxypropyl beta-cyclodextrin (HPdetaCD) and [D-Trp6, des-Gly10] LHRH ethylamide (deslorelin), a peptide drug.	2-Hydroxypropyl-beta-cyclodextrin	114-145	transient receptor potential cation channel subfamily C member 6	Homo sapiens	164-168
11301040-0	2001	Hydroxypropyl-beta-cyclodextrin as delivery system for thyroid hormones, regulating glutathione S-transferase expression in rat hepatocyte co-cultures.	2-Hydroxypropyl-beta-cyclodextrin	0-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	84-109
10479352-6	1999	However, after spray-drying beta-galactosidase in the presence of HP-beta-CD, or HP-beta-CD and sucrose, full catalytic activity was exhibited on reconstitution.	2-Hydroxypropyl-beta-cyclodextrin	66-76	galactosidase beta 1	Homo sapiens	28-46
10944779-1	2000	The complex formation of amylobarbitone (AMB) with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was investigated in aqueous solution and in the solid state.	2-Hydroxypropyl-beta-cyclodextrin	51-84	beta-carotene oxygenase 1	Mus musculus	89-96
10664478-4	2000	To this end, the interaction of ABPP with several cyclodextrin derivatives-alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrin with a degree of substitution 2.7 (HPbetaCD) was studied and the effect of the complexation process on the water solubility of the drug was evaluated.	2-Hydroxypropyl-beta-cyclodextrin	168-176	amyloid beta precursor protein	Homo sapiens	32-36
10664478-8	2000	The dissolution rate of ABPP from the HPbetaCD solid inclusion complex was increased compared to the powdered drug but not differences were found between the complex and a physical mixture with a similar molar ratio.	2-Hydroxypropyl-beta-cyclodextrin	38-46	amyloid beta precursor protein	Homo sapiens	24-28
10479352-0	1999	Hydroxypropyl-beta-cyclodextrin inhibits spray-drying-induced inactivation of beta-galactosidase.	2-Hydroxypropyl-beta-cyclodextrin	0-31	galactosidase beta 1	Homo sapiens	78-96
10479352-6	1999	However, after spray-drying beta-galactosidase in the presence of HP-beta-CD, or HP-beta-CD and sucrose, full catalytic activity was exhibited on reconstitution.	2-Hydroxypropyl-beta-cyclodextrin	81-91	galactosidase beta 1	Homo sapiens	28-46
8639470-9	1996	Sterol 27-hydroxylase specific activity in isolated mitochondria was increased &gt; 10-fold by the addition of 2-hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	111-144	cytochrome P450, family 27, subfamily a, polypeptide 1	Rattus norvegicus	0-21
9514411-4	1998	The FC that accumulated due to ACAT inhibition was more readily available for efflux to 2-hydroxypropyl-beta-cyclodextrin (which removes cholesterol from the plasma membrane) than FC in untreated control cells.	2-Hydroxypropyl-beta-cyclodextrin	88-121	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	31-35
9526678-0	1998	Improved assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by the use of hydroxypropyl-beta-cyclodextrin and an NADPH-regenerating system.	2-Hydroxypropyl-beta-cyclodextrin	92-123	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	37-68
8582025-0	1995	Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-beta-cyclodextrin.	2-Hydroxypropyl-beta-cyclodextrin	127-158	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
8820113-2	1996	27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than cholesterol (IC50 values of 8 mu M and 142 mu M for 27-hydroxycholesterol and cholesterol, respectively) when the sterols were delivered to cells from 2-hydroxypropyl-beta-cyclodextrin (beta-CD)-solubilized solutions.	2-Hydroxypropyl-beta-cyclodextrin	243-276	low density lipoprotein receptor	Homo sapiens	65-77
8820113-2	1996	27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than cholesterol (IC50 values of 8 mu M and 142 mu M for 27-hydroxycholesterol and cholesterol, respectively) when the sterols were delivered to cells from 2-hydroxypropyl-beta-cyclodextrin (beta-CD)-solubilized solutions.	2-Hydroxypropyl-beta-cyclodextrin	278-285	low density lipoprotein receptor	Homo sapiens	65-77