PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22732396-4 2012 Desacyl ghrelin, hexarelin, EP80317, and GHRP-6 all significantly inhibited ACE activity in vitro; by comparison, the efficacies of ghrelin and MK-0677 were significantly lower, suggesting that ACE-inhibiting activity is unrelated to ligand affinity to GHS-R1a. EP80317 28-35 angiotensin I converting enzyme Homo sapiens 76-79 11796502-7 2002 In these cells, hexarelin and EP-80317, but not ghrelin or MK-0677, caused a dose-dependent inhibition of IGF-II-stimulated thymidine incorporation and cell growth at concentrations close to their binding affinity. EP80317 30-38 insulin like growth factor 2 Homo sapiens 106-112 19382238-6 2009 Interestingly, 10(-7) M desacyl-ghrelin, hexarelin, and EP80317 in the nanomolar range effectively counteracted fAbeta(25-35) stimulation of IL-6 mRNA levels, whereas ghrelin was ineffective. EP80317 56-63 FA complementation group A Homo sapiens 112-118 19382238-7 2009 Similarly, the effects of fAbeta(25-35) on IL-1beta mRNA levels were attenuated by desacyl-ghrelin, hexarelin, and EP80317, but not ghrelin. EP80317 115-122 FA complementation group A Homo sapiens 26-32 19382238-10 2009 We conclude that desacyl-ghrelin, hexarelin, and EP80317 might interfere with fAbeta activation of CD36 in microglia cells. EP80317 49-56 FA complementation group A Homo sapiens 78-84 28018175-13 2016 Predictably, EP-80317 administration reduced both duration and severity of seizures, prevented the increase in FosB/DeltaFosB levels in the first session, and partially counteracted the increase in p-ERK1/2 levels in the third session. EP80317 13-21 FBJ osteosarcoma oncogene B Mus musculus 111-115 29018345-0 2017 Involvement of PPARgamma in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist. EP80317 59-67 peroxisome proliferator activated receptor gamma Mus musculus 15-24 29018345-0 2017 Involvement of PPARgamma in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist. EP80317 59-67 growth hormone secretagogue receptor Mus musculus 71-87 29018345-3 2017 In our study, we challenged the hypothesis that PPARgamma could be involved in the anticonvulsant effects of EP-80317, a ghrelin receptor antagonist. EP80317 109-117 peroxisome proliferator activated receptor gamma Mus musculus 48-57 29018345-3 2017 In our study, we challenged the hypothesis that PPARgamma could be involved in the anticonvulsant effects of EP-80317, a ghrelin receptor antagonist. EP80317 109-117 ghrelin Mus musculus 121-128 29018345-14 2017 Overall, these results support the hypothesis that PPARgamma is able to modulate seizures and mediates the anticonvulsant effects of EP-80317. EP80317 133-141 peroxisome proliferator activated receptor gamma Mus musculus 51-60 28018175-7 2016 To characterize a group in which seizures could be prevented by pharmacological treatment, we also considered pretreatment with the ghrelin receptor antagonist EP-80317 (330 mug/kg). EP80317 160-168 growth hormone secretagogue receptor Mus musculus 132-148 28018175-13 2016 Predictably, EP-80317 administration reduced both duration and severity of seizures, prevented the increase in FosB/DeltaFosB levels in the first session, and partially counteracted the increase in p-ERK1/2 levels in the third session. EP80317 13-21 mitogen-activated protein kinase 3 Mus musculus 200-206