PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29710464-7	2018	The protective effect of CDP was then evaluated on the basis of cell viability, lactate dehydrogenase (LDH) leakage, [Ca2+]i, mitochondrial membrane potential (MMP)and cell apoptosis, and redox status after reperfusion was evaluated by assaying reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity.	Cytidine Diphosphate	25-28	catalase	Rattus norvegicus	276-284
29710464-7	2018	The protective effect of CDP was then evaluated on the basis of cell viability, lactate dehydrogenase (LDH) leakage, [Ca2+]i, mitochondrial membrane potential (MMP)and cell apoptosis, and redox status after reperfusion was evaluated by assaying reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity.	Cytidine Diphosphate	25-28	catalase	Rattus norvegicus	286-289
29710464-14	2018	Overall, the results suggested that CDP exerts neuroprotective effect against OGD/RP-induced injury by inhibiting oxidative stress and regulating the DJ-1 pathway.	Cytidine Diphosphate	36-39	Parkinsonism associated deglycase	Rattus norvegicus	150-154
29335339-5	2018	In both cell models, inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions.	Cytidine Diphosphate	91-95	utrophin	Homo sapiens	35-39
29335339-5	2018	In both cell models, inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions.	Cytidine Diphosphate	91-95	fission, mitochondrial 1	Homo sapiens	40-44
28673963-3	2017	Here, we examined the PAP-mediated regulation of CHO1-encoded phosphatidylserine synthase (PSS), which catalyzes the committed step for the synthesis of major phospholipids via the CDP-diacylglycerol pathway.	Cytidine Diphosphate	181-184	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	49-53
26443863-1	2015	Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway.	Cytidine Diphosphate	197-220	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	168-173
26867804-5	2016	Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3).	Cytidine Diphosphate	49-52	tumor protein p53	Homo sapiens	149-152
26867804-9	2016	Collectively, these results demonstrate that the induction of p53 peri-operatively protects bone healing from the toxic effects of CDP, while maintaining OS toxicity.	Cytidine Diphosphate	131-134	tumor protein p53	Homo sapiens	62-65
27619562-8	2016	This study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neuroprotective in a MPTP animal model.	Cytidine Diphosphate	92-96	collapsin response mediator protein 1	Mus musculus	43-47
27619562-8	2016	This study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neuroprotective in a MPTP animal model.	Cytidine Diphosphate	92-96	collapsin response mediator protein 1	Mus musculus	69-73
28335578-6	2017	Moreover, the significant decrease in CDP pool induced by high-dose Ara-C might further accelerate the reduction of dCTP, which then aggravates DNA synthesis disturbance.	Cytidine Diphosphate	38-41	cut up	Drosophila melanogaster	116-120
27502364-2	2016	B cell-specific deletion of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway, led to augmented IgM secretion and reduced IgG production, suggesting that PtdCho synthesis is required for germinal center reactions.	Cytidine Diphosphate	118-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	28-73
27502364-2	2016	B cell-specific deletion of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme in the CDP-choline pathway, led to augmented IgM secretion and reduced IgG production, suggesting that PtdCho synthesis is required for germinal center reactions.	Cytidine Diphosphate	118-121	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	75-83
27619562-5	2016	Inhibition of Drp1 activation by a selective peptide inhibitor P110, blocked MPTP-induced Drp1 mitochondrial translocation and attenuated dopaminergic neuronal loss, dopaminergic nerve terminal damage and behavioral deficits caused by MPTP.	Cytidine Diphosphate	63-67	collapsin response mediator protein 1	Mus musculus	14-18
27619562-5	2016	Inhibition of Drp1 activation by a selective peptide inhibitor P110, blocked MPTP-induced Drp1 mitochondrial translocation and attenuated dopaminergic neuronal loss, dopaminergic nerve terminal damage and behavioral deficits caused by MPTP.	Cytidine Diphosphate	63-67	collapsin response mediator protein 1	Mus musculus	90-94
27155231-3	2016	Multiple turnover kinetics show that Sml1 inhibition of dGTP/ADP- and ATP/CDP-bound ScRR follows a mixed inhibition mechanism.	Cytidine Diphosphate	74-77	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	37-41
26819076-6	2016	Low dose of CDP was found to induce the expression of chemokine (C-X-C motif) receptor 4 (CXCR4), which is an important stemness marker in cancer stem cells as well as a promising therapeutic target for ovarian cancer treatment.	Cytidine Diphosphate	12-15	C-X-C motif chemokine receptor 4	Homo sapiens	54-88
26819076-6	2016	Low dose of CDP was found to induce the expression of chemokine (C-X-C motif) receptor 4 (CXCR4), which is an important stemness marker in cancer stem cells as well as a promising therapeutic target for ovarian cancer treatment.	Cytidine Diphosphate	12-15	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
26227175-7	2015	A lower value was obtained for [CuH(C-Asp)](2+) (E"(0) =24 mV versus NHE).	Cytidine Diphosphate	36-41	solute carrier family 9 member C1	Homo sapiens	69-72
25659034-2	2015	In this study, we investigated the role of CMP/UMP kinase (CMPK), an enzyme catalyzes CDP formation, in DNA repair.	Cytidine Diphosphate	86-89	cytidine/uridine monophosphate kinase 1	Homo sapiens	59-63
26241051-2	2015	Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation.	Cytidine Diphosphate	163-183	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	82-87
25615281-8	2015	In summary, we identified novel somatic missense ETNK1 mutations that were most frequent in SM with eosinophilia and CMML; this suggests a potential pathogenetic role for dysregulated cytidine diphosphate-ethanolamine pathway metabolites in these diseases.	Cytidine Diphosphate	184-204	ethanolamine kinase 1	Homo sapiens	49-54
25595536-5	2015	CDP in turn gives rise to plasmacytoid DCs and predendritic cells (pre-mDCs) that are common precursor of myeloid CD11b+ and CD8alpha(+) DCs.	Cytidine Diphosphate	0-3	integrin subunit alpha M	Homo sapiens	114-119
25595536-5	2015	CDP in turn gives rise to plasmacytoid DCs and predendritic cells (pre-mDCs) that are common precursor of myeloid CD11b+ and CD8alpha(+) DCs.	Cytidine Diphosphate	0-3	CD8a molecule	Homo sapiens	125-133
25659034-4	2015	Exogenous supply of cytidine or deoxycytidine facilitates DNA repair dependent on CMPK in serum-deprived cells, suggesting that the synthesis of dCDP or CDP determines the rate of repair.	Cytidine Diphosphate	146-149	cytidine/uridine monophosphate kinase 1	Homo sapiens	82-86
24758576-6	2014	Most significantly, we demonstrated that inhibition of Drp1 by the Drp1 peptide inhibitor P110, which was developed recently by our group, abolished p53 association with the mitochondria and reduced brain infarction in rats subjected to brain ischaemia/reperfusion injury.	Cytidine Diphosphate	90-94	dynamin 1-like	Rattus norvegicus	55-59
25487918-1	2015	Choline kinase alpha (CHKA; here designated as ChoKalpha) is the first enzyme in the CDP-choline pathway, implicated in phospholipids metabolism.	Cytidine Diphosphate	85-88	choline kinase alpha	Homo sapiens	0-20
25487918-1	2015	Choline kinase alpha (CHKA; here designated as ChoKalpha) is the first enzyme in the CDP-choline pathway, implicated in phospholipids metabolism.	Cytidine Diphosphate	85-88	choline kinase alpha	Homo sapiens	22-26
24758576-6	2014	Most significantly, we demonstrated that inhibition of Drp1 by the Drp1 peptide inhibitor P110, which was developed recently by our group, abolished p53 association with the mitochondria and reduced brain infarction in rats subjected to brain ischaemia/reperfusion injury.	Cytidine Diphosphate	90-94	dynamin 1-like	Rattus norvegicus	67-71
24758576-6	2014	Most significantly, we demonstrated that inhibition of Drp1 by the Drp1 peptide inhibitor P110, which was developed recently by our group, abolished p53 association with the mitochondria and reduced brain infarction in rats subjected to brain ischaemia/reperfusion injury.	Cytidine Diphosphate	90-94	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	149-152
24758576-8	2014	We propose that a Drp1 inhibitor such as P110 is a possible therapeutic agent for diseases in which hyperactivated Drp1 contributes to the pathology.	Cytidine Diphosphate	41-45	dynamin 1-like	Rattus norvegicus	18-22
24758576-8	2014	We propose that a Drp1 inhibitor such as P110 is a possible therapeutic agent for diseases in which hyperactivated Drp1 contributes to the pathology.	Cytidine Diphosphate	41-45	dynamin 1-like	Rattus norvegicus	115-119
23813973-5	2013	In both LRRK2 G2019S-expressing cells and PD patient fibroblasts carrying this specific mutant, treatment with P110, a selective peptide inhibitor of fission dynamin-related protein 1 (Drp1) recently developed in our lab, reduced mitochondrial fragmentation and damage, and corrected excessive autophagy.	Cytidine Diphosphate	111-115	leucine rich repeat kinase 2	Homo sapiens	8-13
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Cytidine Diphosphate	73-76	choline kinase alpha	Homo sapiens	137-141
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Cytidine Diphosphate	73-76	choline kinase alpha	Homo sapiens	151-176
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Cytidine Diphosphate	73-76	phosphate cytidylyltransferase 1A, choline	Homo sapiens	193-199
24440820-4	2014	The transcription of two genes in particular encoding key enzymes in the CDP-choline pathway for PtdCho biosynthesis are stimulated; the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform.	Cytidine Diphosphate	73-76	phosphate cytidylyltransferase 1A, choline	Homo sapiens	213-264
24136823-5	2013	However, [3H]choline labeling experiments in camptothecin-treated MCF7 cells and MCF7 cells expressing caspase 3 (MCF7-C3) revealed a global suppression of the CDP-choline pathway that was consistent with inhibition of a step prior to CCTalpha.	Cytidine Diphosphate	160-163	caspase 3	Homo sapiens	103-112
24136823-5	2013	However, [3H]choline labeling experiments in camptothecin-treated MCF7 cells and MCF7 cells expressing caspase 3 (MCF7-C3) revealed a global suppression of the CDP-choline pathway that was consistent with inhibition of a step prior to CCTalpha.	Cytidine Diphosphate	160-163	phosphate cytidylyltransferase 1A, choline	Homo sapiens	235-243
23813973-5	2013	In both LRRK2 G2019S-expressing cells and PD patient fibroblasts carrying this specific mutant, treatment with P110, a selective peptide inhibitor of fission dynamin-related protein 1 (Drp1) recently developed in our lab, reduced mitochondrial fragmentation and damage, and corrected excessive autophagy.	Cytidine Diphosphate	111-115	dynamin 1 like	Homo sapiens	158-183
23813973-5	2013	In both LRRK2 G2019S-expressing cells and PD patient fibroblasts carrying this specific mutant, treatment with P110, a selective peptide inhibitor of fission dynamin-related protein 1 (Drp1) recently developed in our lab, reduced mitochondrial fragmentation and damage, and corrected excessive autophagy.	Cytidine Diphosphate	111-115	dynamin 1 like	Homo sapiens	185-189
23155050-2	2013	As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is implicated in the provision of membranes and bioactive lipids necessary of cell proliferation.	Cytidine Diphosphate	35-38	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	73-118
23563481-9	2013	Compared with radiation alone, chloroquine phosphate (CDP) or 3AB combined with IR significantly decreased cell viability, as well as the autophagic ratio and LC3-II protein levels.	Cytidine Diphosphate	54-57	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	159-162
23547051-3	2013	C/EBPalpha was needed for differentiation from stem/progenitor cells to common DC progenitors (CDPs), but not for transition of CDP to mature DCs.	Cytidine Diphosphate	95-98	CCAAT enhancer binding protein alpha	Homo sapiens	0-10
23155050-2	2013	As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is implicated in the provision of membranes and bioactive lipids necessary of cell proliferation.	Cytidine Diphosphate	35-38	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	120-128
21875690-5	2011	This observation is important because Lro1p similar to the enzymes of the CDP-Etn pathway is a component of the ER.	Cytidine Diphosphate	74-77	phospholipid:diacylglycerol acyltransferase	Saccharomyces cerevisiae S288C	38-43
22138197-2	2012	cytidine-5"-diphosphate (CDP)-choline administration on the activation of oxytocin and vasopressin neurons in the supraoptic (SON) and paraventricular nuclei (PVN), using the immunohistochemical identification of c-Fos expression as a marker of neuronal activation and to correlate this with the plasma hormone levels.	Cytidine Diphosphate	0-23	arginine vasopressin	Rattus norvegicus	87-98
22138197-2	2012	cytidine-5"-diphosphate (CDP)-choline administration on the activation of oxytocin and vasopressin neurons in the supraoptic (SON) and paraventricular nuclei (PVN), using the immunohistochemical identification of c-Fos expression as a marker of neuronal activation and to correlate this with the plasma hormone levels.	Cytidine Diphosphate	0-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	213-218
22138197-2	2012	cytidine-5"-diphosphate (CDP)-choline administration on the activation of oxytocin and vasopressin neurons in the supraoptic (SON) and paraventricular nuclei (PVN), using the immunohistochemical identification of c-Fos expression as a marker of neuronal activation and to correlate this with the plasma hormone levels.	Cytidine Diphosphate	25-28	arginine vasopressin	Rattus norvegicus	87-98
21625901-2	2012	In this work, the inclusion complexes of cyclic decapeptide (CDP) with the 1-phenyl-1-propanol enantiomers (E-PP) are firstly studied using the density functional theory (DFT) B3LYP method.	Cytidine Diphosphate	61-64	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	178-181
18565758-10	2008	Despite a solution binding constant favoring the S-protein/S-peptide complex, CDP/CTP remains electrostatically bound to the S-protein in the gas-phase dissociation experiment.	Cytidine Diphosphate	78-81	vitronectin	Homo sapiens	125-134
21397653-8	2011	Taken together, CDP inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production.	Cytidine Diphosphate	16-19	matrix metallopeptidase 1	Homo sapiens	41-46
21397653-8	2011	Taken together, CDP inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production.	Cytidine Diphosphate	16-19	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-111
21397653-8	2011	Taken together, CDP inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production.	Cytidine Diphosphate	16-19	cellular communication network factor 1	Homo sapiens	116-121
21397653-8	2011	Taken together, CDP inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production.	Cytidine Diphosphate	16-19	C-C motif chemokine ligand 2	Homo sapiens	126-131
19141610-3	2009	In S. cerevisiae, the rate-determining step in the synthesis of phosphatidylcholine via the CDP-choline pathway is catalyzed by Pct1.	Cytidine Diphosphate	92-95	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	128-132
18765732-3	2008	We now show that A. phagocytophilum infection also enhances the binding of CDP to the promoters of human neutrophil peptide 1 and C/EBPepsilon--molecules important for neutrophil defense and maturation--suggesting that this is a general strategy used by this pathogen to alter polymorphonuclear leukocyte function.	Cytidine Diphosphate	75-78	CCAAT enhancer binding protein epsilon	Homo sapiens	130-142
18565758-9	2008	CAD of the RNase S-CDP and CTP complexes dissociates the S-peptide from the remaining S-protein/nucleotide complex; further dissociation of the S-protein/nucleotide complex fragments a covalent phosphate bond of the nucleotide with subsequent release of CMP.	Cytidine Diphosphate	19-22	vitronectin	Homo sapiens	86-95
18565758-9	2008	CAD of the RNase S-CDP and CTP complexes dissociates the S-peptide from the remaining S-protein/nucleotide complex; further dissociation of the S-protein/nucleotide complex fragments a covalent phosphate bond of the nucleotide with subsequent release of CMP.	Cytidine Diphosphate	19-22	vitronectin	Homo sapiens	144-153
21987614-17	2011	Twelve hours after CDP induction, the expression of hepatic Bax was more significant in the 15 mmHg group than in the 10 mmHg group.	Cytidine Diphosphate	19-22	apoptosis regulator BAX	Oryctolagus cuniculus	60-63
21459047-4	2011	When bronchial explants were exposed to Der p and CDP 870 for 24h, CDP 870 caused a significant reduction in TNF-alpha release both at baseline and following stimulation with Der p allergen.	Cytidine Diphosphate	50-53	tumor necrosis factor	Homo sapiens	109-118
21459047-4	2011	When bronchial explants were exposed to Der p and CDP 870 for 24h, CDP 870 caused a significant reduction in TNF-alpha release both at baseline and following stimulation with Der p allergen.	Cytidine Diphosphate	67-70	tumor necrosis factor	Homo sapiens	109-118
21459047-5	2011	The bronchial biopsies showed significant upregulation of TNF-alpha positive cells and ICAM-1 following exposure to Der p (p=0.03) and this was reduced in the presence of CDP-870.	Cytidine Diphosphate	171-174	intercellular adhesion molecule 1	Homo sapiens	87-93
21504799-1	2011	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis.	Cytidine Diphosphate	122-125	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
21504799-1	2011	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine (PC) synthesis.	Cytidine Diphosphate	122-125	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-55
21397653-6	2011	CDP (10 or 5mg/ml) diminished UVB-induced MMP-1 and CYR61 mRNA expression and MCP-1 production, whereas, UVB-suppressed procollagen and TbRII mRNA was restored by CDP treatment.	Cytidine Diphosphate	0-3	matrix metallopeptidase 1	Homo sapiens	42-47
21397653-6	2011	CDP (10 or 5mg/ml) diminished UVB-induced MMP-1 and CYR61 mRNA expression and MCP-1 production, whereas, UVB-suppressed procollagen and TbRII mRNA was restored by CDP treatment.	Cytidine Diphosphate	0-3	cellular communication network factor 1	Homo sapiens	52-57
21397653-6	2011	CDP (10 or 5mg/ml) diminished UVB-induced MMP-1 and CYR61 mRNA expression and MCP-1 production, whereas, UVB-suppressed procollagen and TbRII mRNA was restored by CDP treatment.	Cytidine Diphosphate	0-3	C-C motif chemokine ligand 2	Homo sapiens	78-83
19667100-2	2009	The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway.	Cytidine Diphosphate	147-150	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	22-26
19667100-2	2009	The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway.	Cytidine Diphosphate	147-150	phosphorylcholine cytidylyltransferase2	Arabidopsis thaliana	31-35
19420237-6	2009	Overexpression of active ATF6alpha induces PtdCho biosynthesis and modulates the CDP-choline pathway differently than does enforced expression of XBP1(S).	Cytidine Diphosphate	81-84	activating transcription factor 6	Homo sapiens	25-34
19707435-1	2008	CONTEXT: Certolizumab pegol (CDP 870) is a new anti-tumor necrosis factor (TNF) therapy currently in development for the treatment of Crohn"s disease, rheumatoid arthritis, and psoriasis.	Cytidine Diphosphate	29-32	tumor necrosis factor	Homo sapiens	47-73
18976223-3	2008	The NTPase follows Michaelis-Menten kinetics in the range of investigated substrate concentrations, the apparent K(m) values for UTP, ITP, GTP, CTP, CDP, and ATP being 86, 25, 41, 150, 500, and 260 microM, respectively.	Cytidine Diphosphate	149-152	cancer-related nucleoside-triphosphatase homolog	Bos taurus	4-10
19707435-1	2008	CONTEXT: Certolizumab pegol (CDP 870) is a new anti-tumor necrosis factor (TNF) therapy currently in development for the treatment of Crohn"s disease, rheumatoid arthritis, and psoriasis.	Cytidine Diphosphate	29-32	tumor necrosis factor	Homo sapiens	75-78
17953352-6	2007	CONCLUSION: CDP has the ability to reactivate the hypermethylated GSTP1 gene promoter activity.	Cytidine Diphosphate	12-15	glutathione S-transferase pi 1	Homo sapiens	66-71
17881569-3	2007	The essential requirement for SEC14 can be bypassed by inactivation of (i) the CDP-choline pathway for phosphatidylcholine synthesis or (ii) KES1, which encodes an oxysterol binding protein.	Cytidine Diphosphate	79-82	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	30-35
17881569-5	2007	The results indicate that inactivation of the CDP-choline pathway allows cells with inactivated SEC14 to live through a mechanism distinct from that of inactivation of KES1.	Cytidine Diphosphate	46-49	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	96-101
17213183-5	2007	Furthermore, overexpression experiments demonstrated that raising the activity of CCT, but not cholinephosphotransferase, is sufficient to augment PtdCho biosynthesis in fibroblasts, indicating that XBP-1(S) increases the output of the CDP-choline pathway primarily via its effects on CCT.	Cytidine Diphosphate	236-239	X-box binding protein 1	Homo sapiens	199-204
17608725-1	2007	Methylanthraniloyl derivatives of ATP and CDP were used in vitro as fluorescent probes for the donor-binding and acceptor-binding sites of human UMP-CMP kinase, a nucleoside salvage pathway kinase.	Cytidine Diphosphate	42-45	cytidine/uridine monophosphate kinase 1	Homo sapiens	145-159
16861741-1	2006	Ethanolamine kinase catalyzes the first step in the CDP-ethanolamine pathway for the formation of the major membrane phospholipid phosphatidylethanolamine (PtdEtn).	Cytidine Diphosphate	52-55	choline kinase beta	Mus musculus	0-19
17148547-5	2007	The purified ORF3 product clearly converted ent-CDP into PMD.	Cytidine Diphosphate	48-51	hypothetical protein	Escherichia coli	13-17
16817320-5	2006	Although an acid labile autophosphorylation intermediate of Hsp70 and its cytidine diphosphate-dependent dephosphorylation were detected in wild-type Hsp70, they were markedly suppressed in the H89S mutation of Hsp70, but not on the H227S mutation.	Cytidine Diphosphate	74-94	heat shock protein family A (Hsp70) member 4	Homo sapiens	150-155
16817320-5	2006	Although an acid labile autophosphorylation intermediate of Hsp70 and its cytidine diphosphate-dependent dephosphorylation were detected in wild-type Hsp70, they were markedly suppressed in the H89S mutation of Hsp70, but not on the H227S mutation.	Cytidine Diphosphate	74-94	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65
16817320-5	2006	Although an acid labile autophosphorylation intermediate of Hsp70 and its cytidine diphosphate-dependent dephosphorylation were detected in wild-type Hsp70, they were markedly suppressed in the H89S mutation of Hsp70, but not on the H227S mutation.	Cytidine Diphosphate	74-94	heat shock protein family A (Hsp70) member 4	Homo sapiens	150-155
16084485-8	2005	The purine nucleoside diphosphates and triphosphates cause aconitase inactivation, but the monophosphates and CDP do not, consistent with the known nucleotide specificity of UCP3.	Cytidine Diphosphate	110-113	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	174-178
16172116-1	2005	In eukaryotes, neuropathy target esterase (Nte1p in yeast) deacylates phosphatidylcholine derived exclusively from the CDP-choline pathway to produce glycerophosphocholine (GroPCho) and release two fatty acids.	Cytidine Diphosphate	119-122	lysophospholipase	Saccharomyces cerevisiae S288C	43-48
16334566-9	2005	Methylation-specific bands of CpG islands in p16 gene" promoter were still existed in Huh-7 and T47D, while unmethylation-specific bands appeared in Huh-7 after the cells being treated with 25, 50, 75 and 100 micromol/ L of CDP for 6 days as well as in T47D after the cells being treated with 50, 75 and 100 micromol/L of CDP for 6 days.	Cytidine Diphosphate	224-227	cyclin dependent kinase inhibitor 2A	Homo sapiens	45-48
16334566-9	2005	Methylation-specific bands of CpG islands in p16 gene" promoter were still existed in Huh-7 and T47D, while unmethylation-specific bands appeared in Huh-7 after the cells being treated with 25, 50, 75 and 100 micromol/ L of CDP for 6 days as well as in T47D after the cells being treated with 50, 75 and 100 micromol/L of CDP for 6 days.	Cytidine Diphosphate	322-325	cyclin dependent kinase inhibitor 2A	Homo sapiens	45-48
16334566-11	2005	After the cells being treated with 50 micromol/L of CDP, the methylation-specific bands of CpG island in p16 gene" promoter were still existed in Huh-7 and T47D; unmethylation-specific bands appeared at 12 h and lasted to 144 h in Huh-7 while at 72 h and lasted to 144 h in T47D.	Cytidine Diphosphate	52-55	cyclin dependent kinase inhibitor 2A	Homo sapiens	105-108
16334566-11	2005	After the cells being treated with 50 micromol/L of CDP, the methylation-specific bands of CpG island in p16 gene" promoter were still existed in Huh-7 and T47D; unmethylation-specific bands appeared at 12 h and lasted to 144 h in Huh-7 while at 72 h and lasted to 144 h in T47D.	Cytidine Diphosphate	52-55	MIR7-3 host gene	Homo sapiens	146-151
16334566-11	2005	After the cells being treated with 50 micromol/L of CDP, the methylation-specific bands of CpG island in p16 gene" promoter were still existed in Huh-7 and T47D; unmethylation-specific bands appeared at 12 h and lasted to 144 h in Huh-7 while at 72 h and lasted to 144 h in T47D.	Cytidine Diphosphate	52-55	MIR7-3 host gene	Homo sapiens	231-236
16334566-12	2005	CONCLUSION: CDP has inhibition effect on the cancer cell lines and has the ability to reverse the hypermethylated p16 gene promoter.	Cytidine Diphosphate	12-15	cyclin dependent kinase inhibitor 2A	Homo sapiens	114-117
15723057-6	2005	These results indicate that Nir2 is involved in maintaining a critical DAG pool in the Golgi apparatus by regulating its consumption via the CDP-choline pathway, demonstrating the interface between secretion from the Golgi and lipid homeostasis.	Cytidine Diphosphate	141-144	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	28-32
16279369-28	2005	In those with serum T < 50 ng/ dl our data suggest that a single injection of HCG 15 IU/kg, with serum T determined 48 hours later, is more discriminatory and offers the most reliable, easy to perform, least painful, and by far the most cost effective test to differentiate CDP from HH.	Cytidine Diphosphate	277-280	HLA complex group 15	Homo sapiens	81-87
15669190-3	2004	RESULTS: (1) At different incubation-time, i.e., 5, 10, 20, 40, and 60 minutes, the highest Mg2+-ATPase activity was observed when myosin was in the state of CDP, the medium was CIP of myosin, and the lowest was the unphosphorylated myosin.	Cytidine Diphosphate	158-161	myosin heavy chain 14	Homo sapiens	131-137
21961343-8	2005	The ovaries with higher follicle development belonged to group 2 (EV) while preserving intrinsic follicular nervous activity as shown by a positive immunoreaction to PS-100 & GFAP.	Cytidine Diphosphate	166-172	glial fibrillary acidic protein	Homo sapiens	179-183
15669190-3	2004	RESULTS: (1) At different incubation-time, i.e., 5, 10, 20, 40, and 60 minutes, the highest Mg2+-ATPase activity was observed when myosin was in the state of CDP, the medium was CIP of myosin, and the lowest was the unphosphorylated myosin.	Cytidine Diphosphate	158-161	myosin heavy chain 14	Homo sapiens	185-191
12761300-6	2003	These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway.	Cytidine Diphosphate	170-173	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	28-33
15024002-4	2004	Our objective was to determine whether inhibition of the CDP-choline pathway for phosphatidylcholine synthesis (by restricting the supply of choline) also impaired VLDL secretion.	Cytidine Diphosphate	57-60	CD320 antigen	Mus musculus	164-168
14597574-3	2003	Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine.	Cytidine Diphosphate	163-166	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	80-120
14597574-3	2003	Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine.	Cytidine Diphosphate	163-166	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	122-125
12761300-6	2003	These results indicate that Scs2p can contribute to coordinated phospholipid metabolism including INO1 expression by regulating phosphatidylcholine synthesis through the CDP-choline pathway.	Cytidine Diphosphate	170-173	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	98-102
12221122-12	2002	This pinpointed glycine 156 within the catalytic motif as being responsible for the dual CDP-alcohol specificity of CEPT1, whereas mutations within helix 214-228 allowed for the orientation of transmembrane helices surrounding the catalytic site to be definitively positioned.	Cytidine Diphosphate	89-92	choline/ethanolamine phosphotransferase 1	Homo sapiens	116-121
12221122-9	2002	CTP:phosphocholine cytidylyltransferase alpha is found immediately upstream cholinephosphotransferase, and it translocates from a soluble nuclear location to the nuclear membrane in response to activators of the CDP-choline pathway.	Cytidine Diphosphate	212-215	phosphate cytidylyltransferase 1A, choline	Homo sapiens	0-45
12626113-5	2003	In addition, poplar glutaredoxin is able to reduce the Escherichia coli ribonucleotide reductase 1a (in vitro reduction of cytidine diphosphate).	Cytidine Diphosphate	123-143	glutaredoxin	Homo sapiens	20-32
12167660-4	2002	To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids.	Cytidine Diphosphate	117-120	Gat1p	Saccharomyces cerevisiae S288C	140-144
12167660-4	2002	To address why we observed alterations in phospholipid turnover specific to phosphatidylcholine produced through the CDP-choline pathway in gat1 and gat2 yeast we tested their sensitivity to various cytotoxic lysolipids and observed that gat2 cells were more sensitive to lysophosphatidylcholine, but not other lysolipids.	Cytidine Diphosphate	117-120	Gat2p	Saccharomyces cerevisiae S288C	149-153
12117562-13	2002	Such regulation might occur at least at two different levels of the CDP-choline pathway: on the one hand, PLC operates on CCT activity; on the other, while PGs regulate CPT activity.	Cytidine Diphosphate	68-71	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	122-125
12052891-1	2002	CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells.	Cytidine Diphosphate	123-126	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-45
12052891-1	2002	CTP:phosphocholine cytidylyltransferase alpha (CCT alpha) is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway, the primary route for synthesis of phosphatidylcholine (PtdCho) in eukaryotic cells.	Cytidine Diphosphate	123-126	choline-phosphate cytidylyltransferase A	Cricetulus griseus	47-56
11912132-1	2002	Pyrimidine nucleoside monophosphate kinase [UMP/CMP kinase (UMP/CMPK);EC 2.7.4.14] plays a crucial role in the formation of UDP, CDP, and dCDP, which are required for cellular nucleic acid synthesis.	Cytidine Diphosphate	129-132	cytidine/uridine monophosphate kinase 1	Homo sapiens	44-58
11912132-1	2002	Pyrimidine nucleoside monophosphate kinase [UMP/CMP kinase (UMP/CMPK);EC 2.7.4.14] plays a crucial role in the formation of UDP, CDP, and dCDP, which are required for cellular nucleic acid synthesis.	Cytidine Diphosphate	129-132	cytidine/uridine monophosphate kinase 1	Homo sapiens	60-68
10665999-3	2000	It was shown that TNF-alpha markedly suppresses the incorporation of [3H]proline into both CDP and NCP in confluent cultures of SMCs but not in sparse cultures of the cells.	Cytidine Diphosphate	91-94	tumor necrosis factor	Homo sapiens	18-27
11294911-2	2001	This requirement of Sec14p is relieved by genetic inactivation of the cytidine diphosphate-choline pathway for phosphatidycholine (PtdCho) biosynthesis.	Cytidine Diphosphate	70-90	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	20-26
10858452-9	2000	Comparison of the enzymatic properties of the splice variants revealed a broader substrate specificity for hLALP70v with CTP, UDP, CDP, GTP, and GDP as preferred substrates, while hLALP70 utilized UTP and TTP preferentially.	Cytidine Diphosphate	131-134	ectonucleoside triphosphate diphosphohydrolase 4	Homo sapiens	107-114
10665999-5	2000	In confluent SMCs, the synthesis of CDP was more strongly inhibited by TNF-alpha than that of NCP.	Cytidine Diphosphate	36-39	tumor necrosis factor	Homo sapiens	71-80
10665999-6	2000	When the CDP synthesis was stimulated by transforming growth factor beta, TNF-alpha suppressed the stimulation in both confluent and sparse SMCs.	Cytidine Diphosphate	9-12	tumor necrosis factor	Homo sapiens	74-83
10493918-1	1999	CTP:phosphoethanolamine cytidylyltransferase (ET) is a key regulatory enzyme in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis.	Cytidine Diphosphate	84-87	phosphate cytidylyltransferase 2, ethanolamine	Rattus norvegicus	0-44
10432300-3	1999	The activity of PSS1 in vitro and the synthesis of PtdSer and PtdSer-derived PtdEtn were increased, whereas PtdEtn synthesis from the CDP-ethanolamine pathway was inhibited [Stone, Cui and Vance (1998) J. Biol.	Cytidine Diphosphate	134-137	phosphatidylserine synthase 1	Mus musculus	16-20
10409709-4	1999	The activity was equally high toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate, but there was no activity toward GMP, indicating that the Ynd1 protein belongs to the apyrase family.	Cytidine Diphosphate	101-104	apyrase	Saccharomyces cerevisiae S288C	195-199
10329685-12	1999	Whereas the EKI1 gene product was primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway, the CKI1 gene product was primarily responsible for phosphatidylcholine synthesis via the CDP-choline pathway.	Cytidine Diphosphate	103-106	bifunctional choline kinase/ethanolamine kinase EKI1	Saccharomyces cerevisiae S288C	12-16
10397762-4	1999	We now report that, in addition to a dramatic accumulation of phosphatidylinositol-4-phosphate, sac1 mutants also exhibit a specific acceleration of phosphatidylcholine biosynthesis via the CDP-choline pathway.	Cytidine Diphosphate	190-193	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	96-100
9854020-8	1999	PEMT activity decreased, the levels of PEMT2 mRNA decreased and there was an increase in the activity of CTP:phosphocholine cytidylyltransferase, a key regulatory enzyme in the CDP-choline pathway of phosphatidylcholine biosynthesis.	Cytidine Diphosphate	177-180	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-4
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	107-112
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	11-15
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	27-31
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	17-21
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	153-157
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	169-173
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	189-193
9642212-2	1998	Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature.	Cytidine Diphosphate	40-43	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	143-148
9642212-6	1998	Thus, the PLD1 gene product appears to play an essential role in the suppression of the sec14(ts) defect by CDP-choline pathway mutations, indicating a role for phospholipase D1 in growth and secretion.	Cytidine Diphosphate	108-111	phospholipase D	Saccharomyces cerevisiae S288C	10-14
9642212-6	1998	Thus, the PLD1 gene product appears to play an essential role in the suppression of the sec14(ts) defect by CDP-choline pathway mutations, indicating a role for phospholipase D1 in growth and secretion.	Cytidine Diphosphate	108-111	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	88-93
9555031-5	1998	The activities of soluble and membrane-bound CTP:phosphoethanolamine cytidylyltransferase (ET), the analogous enzyme in the CDP-ethanolamine pathway, did not change significantly throughout this period.	Cytidine Diphosphate	124-127	phosphate cytidylyltransferase 2, ethanolamine	Bos taurus	45-89
9707373-5	1998	Treatment of cells with 100 IU/ml of IFN-alpha decreased levels of both subunits resulting in a reduction in enzyme activity as measured by conversion of CDP to dCDP.	Cytidine Diphosphate	154-157	interferon alpha 1	Homo sapiens	37-46
8978672-1	1996	The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation of the CDP-choline pathway for phosphatidylcholine biosynthesis.	Cytidine Diphosphate	214-217	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	49-55
9148929-3	1997	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells.	Cytidine Diphosphate	80-83	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-39
9148929-3	1997	CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilized by all tissues and is the sole or major PC biosynthetic pathway in all non-hepatic cells.	Cytidine Diphosphate	80-83	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	0-2
9025983-7	1996	Moreover, the inhibitory capacity of sera from asymptomatic CDP (CDP-0) correlated with patients age (r = 0.66, p < 0.05).	Cytidine Diphosphate	60-63	cut like homeobox 1	Homo sapiens	65-70
9806225-2	1998	Pyrimidine nucleotides such as UDP, UTP and cytidine diphosphate reduced the activity of rat purified UGT (phenol UGT) to about 10%, 48% and 46% of the control, respectively, at the same concentration as a donor substrate, UDP-glucuronic acid.	Cytidine Diphosphate	44-64	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	102-105
9806225-2	1998	Pyrimidine nucleotides such as UDP, UTP and cytidine diphosphate reduced the activity of rat purified UGT (phenol UGT) to about 10%, 48% and 46% of the control, respectively, at the same concentration as a donor substrate, UDP-glucuronic acid.	Cytidine Diphosphate	44-64	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	114-117
9252414-1	1997	In yeast, mutations in the CDP-choline pathway for phosphatidylcholine biosynthesis permit the cell to grow even when the SEC14 gene is completely deleted (Cleves, A., McGee, T., Whitters, E., Champion, K., Aitken, J., Dowhan, W., Goebl, M., and Bankaitis, V. (1991) Cell 64, 789-800).	Cytidine Diphosphate	27-30	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	122-127
9252414-2	1997	We report that strains carrying mutations in the CDP-choline pathway, such as cki1, exhibit a choline excretion phenotype due to production of choline during normal turnover of phosphatidylcholine.	Cytidine Diphosphate	49-52	bifunctional choline kinase/ethanolamine kinase CKI1	Saccharomyces cerevisiae S288C	78-82
9139830-2	1997	This requirement can be relieved by inactivation of the cytosine 5"-diphosphate (CDP)-choline pathway for phosphatidylcholine biosynthesis, indicating that Sec14p is an essential component of a regulatory pathway linking phospholipid metabolism with vesicle trafficking (the Sec14p pathway).	Cytidine Diphosphate	81-84	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	156-162
9139830-2	1997	This requirement can be relieved by inactivation of the cytosine 5"-diphosphate (CDP)-choline pathway for phosphatidylcholine biosynthesis, indicating that Sec14p is an essential component of a regulatory pathway linking phospholipid metabolism with vesicle trafficking (the Sec14p pathway).	Cytidine Diphosphate	81-84	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	275-281
8978672-1	1996	The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation of the CDP-choline pathway for phosphatidylcholine biosynthesis.	Cytidine Diphosphate	214-217	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	159-165
8978672-2	1996	These findings indicate that Sec14p functions to alleviate a CDP-choline pathway-mediated toxicity to yeast Golgi secretory function.	Cytidine Diphosphate	61-64	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	29-35
8554542-0	1995	Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.	Cytidine Diphosphate	107-110	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	197-236
8906577-2	1996	In contrast to a general contention in the literature that SM synthase is absent from the brain, our data show that (choline-->CDP-choline-->phosphatidylcholine (PC)-->SM) is the major anabolic route with only a minor contribution to PC via methylation of phosphatidylethanolamine (PE).	Cytidine Diphosphate	130-133	sphingomyelin synthase 2	Homo sapiens	59-70
7961735-5	1994	The CPT1 gene product was responsible for 95% of phosphatidylcholine (PC) synthesis via the CDP-choline pathway in vivo.	Cytidine Diphosphate	92-95	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	4-8
7829476-5	1995	The Ki of the donor substrate analog CDP was also evaluated for the recombinant sialyltransferase with the Val to Ala mutation at residue 220, which produced a 6-fold increase in Km of CMP-NeuAc.	Cytidine Diphosphate	37-40	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	80-97
7816798-4	1995	We now report that SEC14p effects an in vivo depression of CDP-choline pathway activity by inhibiting choline-phosphate cytidylyltransferase (CCTase; EC 2.7.7.15), the rate-determining enzyme of the CDP-choline pathway.	Cytidine Diphosphate	59-62	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	19-25
7816798-4	1995	We now report that SEC14p effects an in vivo depression of CDP-choline pathway activity by inhibiting choline-phosphate cytidylyltransferase (CCTase; EC 2.7.7.15), the rate-determining enzyme of the CDP-choline pathway.	Cytidine Diphosphate	59-62	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	102-140
7816798-4	1995	We now report that SEC14p effects an in vivo depression of CDP-choline pathway activity by inhibiting choline-phosphate cytidylyltransferase (CCTase; EC 2.7.7.15), the rate-determining enzyme of the CDP-choline pathway.	Cytidine Diphosphate	59-62	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	142-148
7816798-4	1995	We now report that SEC14p effects an in vivo depression of CDP-choline pathway activity by inhibiting choline-phosphate cytidylyltransferase (CCTase; EC 2.7.7.15), the rate-determining enzyme of the CDP-choline pathway.	Cytidine Diphosphate	199-202	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	19-25
7816798-4	1995	We now report that SEC14p effects an in vivo depression of CDP-choline pathway activity by inhibiting choline-phosphate cytidylyltransferase (CCTase; EC 2.7.7.15), the rate-determining enzyme of the CDP-choline pathway.	Cytidine Diphosphate	199-202	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	102-140
7816798-4	1995	We now report that SEC14p effects an in vivo depression of CDP-choline pathway activity by inhibiting choline-phosphate cytidylyltransferase (CCTase; EC 2.7.7.15), the rate-determining enzyme of the CDP-choline pathway.	Cytidine Diphosphate	199-202	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	142-148
7809142-7	1994	Together they catalyze the reduction of CDP to dCDP, using dithiothreitol or reduced glutaredoxin, but not thioredoxin, as an electron donor.	Cytidine Diphosphate	40-43	glutaredoxin	Homo sapiens	85-97
7809142-7	1994	Together they catalyze the reduction of CDP to dCDP, using dithiothreitol or reduced glutaredoxin, but not thioredoxin, as an electron donor.	Cytidine Diphosphate	40-43	thioredoxin	Homo sapiens	107-118
7961735-8	1994	Only chimeras expressing the CDP-aminoalcohol specificity region of CPT1 were capable of PC synthesis via the CDP-choline pathway in vivo.	Cytidine Diphosphate	29-32	diacylglycerol cholinephosphotransferase	Saccharomyces cerevisiae S288C	68-72
8294512-3	1994	The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo.	Cytidine Diphosphate	247-250	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	161-167
8294512-3	1994	The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo.	Cytidine Diphosphate	247-250	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	26-32
8294512-4	1994	We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained.	Cytidine Diphosphate	119-122	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	16-22
8281914-2	1993	The purpose of the present study was to investigate the effects of thyroid hormone on the activity of cholinephosphotransferase, the terminal enzyme in the CDP-choline pathway, in guinea pig lung mitochondria and microsomes.	Cytidine Diphosphate	156-159	cholinephosphotransferase 1	Cavia porcellus	102-127
1577759-8	1992	The enzyme also converts N-glycolylneuraminic acid to its corresponding CMP-sialic acid (Km, 2.6 mM), whereas CMP-NeuAc, high CTP concentrations, and other nucleotides (CDP, CMP, ATP, UTP, GTP, and TTP) inhibited the enzyme to different extents.	Cytidine Diphosphate	169-172	alpha tocopherol transfer protein	Rattus norvegicus	198-201
8389981-2	1993	The final step in the de novo synthesis of phosphatidylcholine, a major component of lung surfactant, by the CDP-choline pathway, requires the enzyme cholinephosphotransferase (CPT).	Cytidine Diphosphate	109-112	cholinephosphotransferase 1	Cavia porcellus	150-175
8389981-2	1993	The final step in the de novo synthesis of phosphatidylcholine, a major component of lung surfactant, by the CDP-choline pathway, requires the enzyme cholinephosphotransferase (CPT).	Cytidine Diphosphate	109-112	cholinephosphotransferase 1	Cavia porcellus	177-180
1569062-9	1992	Thioredoxin-dependent reduction of CDP to dCDP by ribonucleotide reductase was effectively inhibited by GS-Se-SG.	Cytidine Diphosphate	35-38	thioredoxin	Bos taurus	0-11
1954254-9	1991	This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway.	Cytidine Diphosphate	136-139	phosphatidylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	44-48
1587797-11	1992	Furthermore, when the CDP-choline pathway was mutationally blocked, choline did not affect INO1 expression, indicating that the metabolism of choline via the CDP-choline pathway is required for INO1 repression.	Cytidine Diphosphate	22-25	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	194-198
1954254-9	1991	This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway.	Cytidine Diphosphate	136-139	bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase	Saccharomyces cerevisiae S288C	58-62
35606779-3	2022	METHODS: In this study, we prepared macrophage-derived exosomes laden with heptapeptide (Hep) as a dynamin-related protein-1 (Drp1)-fission 1 (Fis1) peptide inhibitor P110 to alleviate cerebral ischemia-reperfusion injury by reducing mitochondrial Drp1/Fis1 interaction-mediated astrocytic mitochondrial disorder and promoting the transfer of astrocyte-derived healthy mitochondria into neurons.	Cytidine Diphosphate	167-171	dynamin 1 like	Homo sapiens	99-124
34218011-5	2021	Circular dichroism (CD) demonstrated the preservation of the secondary structure of hGH interacting with CDP, and, further, fluorescence spectroscopy proved the stability of the tertiary structure of the protein.	Cytidine Diphosphate	105-108	gamma-glutamyl hydrolase	Homo sapiens	84-87
1997207-4	1991	The antagonistic action of the CKI gene product on SEC14p function revealed a previously unsuspected influence of biosynthetic activities of the CDP-choline pathway for PC biosynthesis on yeast Golgi function and indicated that SEC14p controls the phospholipid content of yeast Golgi membranes in vivo.	Cytidine Diphosphate	145-148	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	51-57
33237430-5	2021	RESULTS: Adding BVC to EDA slightly increased sensitivity, but not specificity or predictive values, nor the OR for predicting CDP; only EDA-3 showed a trend for predicting CDP (OR 3.701, p = 0.050).	Cytidine Diphosphate	173-176	ectodysplasin A receptor	Homo sapiens	137-142
34234346-3	2021	Here we show that the cytidine diphosphate (CDP)-ethanolamine pathway co-ordinates the expression and localization of CXCR5 with the responses of TFH cells and humoral immunity.	Cytidine Diphosphate	22-42	chemokine (C-X-C motif) receptor 5	Mus musculus	118-123
34234346-3	2021	Here we show that the cytidine diphosphate (CDP)-ethanolamine pathway co-ordinates the expression and localization of CXCR5 with the responses of TFH cells and humoral immunity.	Cytidine Diphosphate	44-47	chemokine (C-X-C motif) receptor 5	Mus musculus	118-123
34234346-4	2021	Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5.	Cytidine Diphosphate	124-127	ethanolamine kinase 1	Mus musculus	83-88
34234346-4	2021	Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5.	Cytidine Diphosphate	124-127	chemokine (C-X-C motif) receptor 5	Mus musculus	348-353
35057792-10	2022	A distinct abnormally increased alveolar type 2 epithelial cell (AT2) were classified with a highly active state but reduced the antimicrobial-related protein expression of LYZ and Chia1 after CDP exposure.	Cytidine Diphosphate	193-196	lysozyme 1	Mus musculus	173-176
35115536-3	2022	Here we show that targeted deletion of serine/threonine kinase 11 (Stk11) encoding tumor suppressor liver kinase b1 (Lkb1) in mouse ECs but not DCs, results in disrupted differentiation of MDPs to CDPs, severe reduction in mature DC numbers and spontaneous tumorigenesis.	Cytidine Diphosphate	197-201	serine/threonine kinase 11	Mus musculus	39-65
35115536-3	2022	Here we show that targeted deletion of serine/threonine kinase 11 (Stk11) encoding tumor suppressor liver kinase b1 (Lkb1) in mouse ECs but not DCs, results in disrupted differentiation of MDPs to CDPs, severe reduction in mature DC numbers and spontaneous tumorigenesis.	Cytidine Diphosphate	197-201	serine/threonine kinase 11	Mus musculus	67-72
35115536-3	2022	Here we show that targeted deletion of serine/threonine kinase 11 (Stk11) encoding tumor suppressor liver kinase b1 (Lkb1) in mouse ECs but not DCs, results in disrupted differentiation of MDPs to CDPs, severe reduction in mature DC numbers and spontaneous tumorigenesis.	Cytidine Diphosphate	197-201	serine/threonine kinase 11	Mus musculus	100-115
35115536-3	2022	Here we show that targeted deletion of serine/threonine kinase 11 (Stk11) encoding tumor suppressor liver kinase b1 (Lkb1) in mouse ECs but not DCs, results in disrupted differentiation of MDPs to CDPs, severe reduction in mature DC numbers and spontaneous tumorigenesis.	Cytidine Diphosphate	197-201	serine/threonine kinase 11	Mus musculus	117-121
35115536-6	2022	Adeno-associated-virus-mediated delivery of genes encoding either soluble Scf or the phosphomimetic mutant Ptbp1T138E proteins rescued the defects of MDP to CDP differentiation and DC shortage in the endothelium specific Stk11 knockout mice.	Cytidine Diphosphate	157-160	KIT ligand	Homo sapiens	74-77
35057792-10	2022	A distinct abnormally increased alveolar type 2 epithelial cell (AT2) were classified with a highly active state but reduced the antimicrobial-related protein expression of LYZ and Chia1 after CDP exposure.	Cytidine Diphosphate	193-196	chitinase, acidic 1	Mus musculus	181-186
35057792-11	2022	Beclin1, LC3B, LAMP2, TGF-ss, and MLPH were up-regulated induced by CDP, promoting autophagy and pulmonary fibrosis.	Cytidine Diphosphate	68-71	beclin 1, autophagy related	Mus musculus	0-7
35057792-11	2022	Beclin1, LC3B, LAMP2, TGF-ss, and MLPH were up-regulated induced by CDP, promoting autophagy and pulmonary fibrosis.	Cytidine Diphosphate	68-71	microtubule-associated protein 1 light chain 3 beta	Mus musculus	9-13
35057792-11	2022	Beclin1, LC3B, LAMP2, TGF-ss, and MLPH were up-regulated induced by CDP, promoting autophagy and pulmonary fibrosis.	Cytidine Diphosphate	68-71	lysosomal-associated membrane protein 2	Mus musculus	15-20
35057792-11	2022	Beclin1, LC3B, LAMP2, TGF-ss, and MLPH were up-regulated induced by CDP, promoting autophagy and pulmonary fibrosis.	Cytidine Diphosphate	68-71	melanophilin	Mus musculus	34-38
2822176-6	1987	We confirmed that a calcium-dependent cysteine protease (CDP) was present in the sera of each of the 15 patients when we used an assay based on the ability of CDP to proteolyse platelet membrane glycoprotein 1b (GP1b) and hence to abolish the ability of CDP-treated normal platelets to agglutinate in the presence of ristocetin and von Willebrand factor.	Cytidine Diphosphate	57-60	glycoprotein Ib platelet subunit alpha	Homo sapiens	212-216
3456745-6	1986	This inhibition reduces the production of cell membrane lyso-phosphatidylcholine (PC) and arachidonic acid from PC, which is produced by transmethylation of PE and cytidine diphosphate (CDP) choline pathway of which the last reaction to PC is mediated by CPT.	Cytidine Diphosphate	164-184	choline phosphotransferase 1	Homo sapiens	255-258
3314871-3	1987	Surprisingly, the mode of inhibition of CDP reduction by dTTP and dTDP was found to be competitive versus CDP.	Cytidine Diphosphate	40-43	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	66-70
3314871-3	1987	Surprisingly, the mode of inhibition of CDP reduction by dTTP and dTDP was found to be competitive versus CDP.	Cytidine Diphosphate	106-109	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	66-70
3022648-3	1986	In the CDP pathways, ethanolaminephosphotransferase (EPT) and cholinephosphotransferase (CPT) had comparable activities.	Cytidine Diphosphate	7-10	choline phosphotransferase 1	Homo sapiens	89-92
3456745-6	1986	This inhibition reduces the production of cell membrane lyso-phosphatidylcholine (PC) and arachidonic acid from PC, which is produced by transmethylation of PE and cytidine diphosphate (CDP) choline pathway of which the last reaction to PC is mediated by CPT.	Cytidine Diphosphate	186-189	choline phosphotransferase 1	Homo sapiens	255-258
3900066-7	1985	Under these conditions, CDP and UDP reductions were inhibited by dADP, dTDP, and dGDP to the same extent observed in the presence of ATP.	Cytidine Diphosphate	24-27	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	71-75
2992446-3	1985	Furthermore, the inhibitors against CANP, NCO-700 (2 and 20 micrograms/ml) that was demonstrated to permeate sarcolemma using 14C-labelled reagent, against CDP, mepacrine (1 and 10 micrograms/ml) or against cyclooxygenase, indomethacin (1 and 10 micrograms/ml) caused no effect on the Ca entry, nigrosin intake nor CPK release under hypoxia.	Cytidine Diphosphate	156-159	calpain 1	Homo sapiens	36-40
6314909-5	1983	Compared to control platelets, the CDP-treated platelets were activated by thrombin more slowly and showed less saturable and nonsaturable binding of thrombin.	Cytidine Diphosphate	35-38	coagulation factor II, thrombin	Homo sapiens	75-83
6698994-11	1984	Both for inactivation of HMG-CoA reductase and for phosphorylation of bovine serum albumin protein, the ability of nucleoside diphosphates to replace ADP decreased in the order ADP greater than CDP, dADP greater than UDP.	Cytidine Diphosphate	194-197	albumin	Rattus norvegicus	77-90
6387175-11	1984	Hydroxyurea, EDTA, dATP, and dTTP inhibited CDP reduction, setting this reductase apart from T4 reductase, which is not inhibited by dATP, and from herpesvirus reductase, which requires no activation and is insensitive to deoxyribonucleoside triphosphate inhibition.	Cytidine Diphosphate	44-47	ttp	Drosophila melanogaster	29-33
6238021-1	1984	The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem.	Cytidine Diphosphate	127-130	myosin heavy chain 14	Homo sapiens	23-29
6238021-1	1984	The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem.	Cytidine Diphosphate	127-130	myosin heavy chain 14	Homo sapiens	197-203
6238021-1	1984	The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem.	Cytidine Diphosphate	127-130	myosin heavy chain 14	Homo sapiens	197-203
6314909-5	1983	Compared to control platelets, the CDP-treated platelets were activated by thrombin more slowly and showed less saturable and nonsaturable binding of thrombin.	Cytidine Diphosphate	35-38	coagulation factor II, thrombin	Homo sapiens	150-158
6314909-8	1983	The decreased binding of thrombin and the exposure of fibrinogen receptors were correlated with the release of surface glycoproteins to the supernatant solution, but the slow activation by thrombin was observed under conditions where no release of labeled glycoproteins was detected (i.e., brief incubations with low concentrations of CDP).	Cytidine Diphosphate	335-338	coagulation factor II, thrombin	Homo sapiens	25-33
6314909-8	1983	The decreased binding of thrombin and the exposure of fibrinogen receptors were correlated with the release of surface glycoproteins to the supernatant solution, but the slow activation by thrombin was observed under conditions where no release of labeled glycoproteins was detected (i.e., brief incubations with low concentrations of CDP).	Cytidine Diphosphate	335-338	coagulation factor II, thrombin	Homo sapiens	189-197
6339684-4	1983	This method involved the reduction of [14C]cytidine diphosphate (CDP) to [14C]deoxycytidine diphosphate with subsequent hydrolysis and separation of the product ([14C]deoxycytidine) from substrate ([14C]cytidine) by Dowex-1-borate ion-exchange chromatography.	Cytidine Diphosphate	65-68	cut-like homeobox 1	Rattus norvegicus	38-63
14328-1	1977	The interaction of Mg2+ with nucleoside disphosphates : ADP, GDP, CDP and UDP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution.	Cytidine Diphosphate	66-69	mucin 7, secreted	Homo sapiens	19-22
7407217-5	1980	Also, GD3 synthase inhibition by CDP was only partially relieved by excess Mg2+.	Cytidine Diphosphate	33-36	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	6-18
338619-4	1977	Studies with HS3 isolated from Achlya and partially purified mammalian ribonucleotide reductase indicated that the compound noncompetitively inhibited the reduction of varying concentrations of the substrates CDP, ADP and GDP with Ki values of 23 micrometer, 14 micron and 16 micron respectively.	Cytidine Diphosphate	209-212	spectrin alpha, erythrocytic 1	Homo sapiens	13-16
33880999-5	2021	Furthermore, application of PC inhibitor, 3-chloro-1,2-dihydroxypropane (CDP), negatively impacts the viability of astrocytoma cells.	Cytidine Diphosphate	73-76	pyruvate carboxylase	Homo sapiens	28-30
34048882-3	2021	Therefore, we have synthesized UDP/CDP analogues containing a stabilizing alpha,beta -methylene bridge as P2Y6R agonists and identified compatible affinity-enhancing pyrimidine modifications.	Cytidine Diphosphate	35-38	pyrimidinergic receptor P2Y6	Homo sapiens	106-111
33454525-8	2021	In addition, molecular docking revealed that TPHP, TCP, CDP and CPF bound to AChE with glide scores of - 7.8, - 8.3, - 8.1 and - 7.3, respectively.	Cytidine Diphosphate	56-59	acetylcholinesterase	Danio rerio	77-81
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	Cytidine Diphosphate	230-233	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32576654-1	2020	The final step of the CDP-ethanolamine pathway is catalyzed by ethanolamine phosphotransferase 1 (EPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1).	Cytidine Diphosphate	22-25	selenoprotein I	Homo sapiens	63-96
32576654-1	2020	The final step of the CDP-ethanolamine pathway is catalyzed by ethanolamine phosphotransferase 1 (EPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1).	Cytidine Diphosphate	22-25	selenoprotein I	Homo sapiens	98-102
32576654-1	2020	The final step of the CDP-ethanolamine pathway is catalyzed by ethanolamine phosphotransferase 1 (EPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1).	Cytidine Diphosphate	22-25	choline/ethanolamine phosphotransferase 1	Homo sapiens	108-149
32576654-1	2020	The final step of the CDP-ethanolamine pathway is catalyzed by ethanolamine phosphotransferase 1 (EPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1).	Cytidine Diphosphate	22-25	choline/ethanolamine phosphotransferase 1	Homo sapiens	151-156
32388635-10	2020	Mechanistic analysis demonstrated that CTSL can proteolytically process CDP/Cux and produce the physiologically relevant p110 isoform, which stably binds to VEGF-D and promotes the transcription of VEGF-D, thus contributing to the angiogenesis of GC.	Cytidine Diphosphate	72-75	cathepsin V	Gallus gallus	39-43
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	Cytidine Diphosphate	230-233	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32298691-1	2020	Citicoline or CDP-choline is a drug, made up by a cytidine 5"-diphosphate moiety and choline, which upon adsorption is rapidly hydrolyzed into cytidine 5"-diphosphate and choline, easily bypassing the blood-brain barrier.	Cytidine Diphosphate	50-73	cut like homeobox 1	Homo sapiens	14-17
32298691-1	2020	Citicoline or CDP-choline is a drug, made up by a cytidine 5"-diphosphate moiety and choline, which upon adsorption is rapidly hydrolyzed into cytidine 5"-diphosphate and choline, easily bypassing the blood-brain barrier.	Cytidine Diphosphate	143-166	cut like homeobox 1	Homo sapiens	14-17
31904962-12	2020	HU treatment of the quaternary complex, alpha2/beta2/ATP/CDP, leads to a similar carboxylate shift spectrum, as observed with beta2 alone.	Cytidine Diphosphate	57-60	glycoprotein hormone subunit alpha 2	Homo sapiens	40-46
31657512-2	2020	Without recourse to enzyme engineering or evolution approaches, here we demonstrate the ability of wild-type cellodextrin phosphorylase (CDP: beta-1,4-glucan linkage-dependent) and laminaridextrin phosphorylase (Pro_7066: beta-1,3-glucan linkage-dependent) to tolerate a number of sugar-1- phosphate substrates, albeit with reduced kinetic efficiency.	Cytidine Diphosphate	137-140	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	142-150
31657512-2	2020	Without recourse to enzyme engineering or evolution approaches, here we demonstrate the ability of wild-type cellodextrin phosphorylase (CDP: beta-1,4-glucan linkage-dependent) and laminaridextrin phosphorylase (Pro_7066: beta-1,3-glucan linkage-dependent) to tolerate a number of sugar-1- phosphate substrates, albeit with reduced kinetic efficiency.	Cytidine Diphosphate	137-140	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	222-230
31708105-5	2020	Here we constructed Cux2-mCherry transgenic mice that reproduce the cortical layer II-IV-specific expression of Cux2, a member of the Cut/Cux/CDP family, using BAC transgenesis and a variety of coordinated cortical layer markers that are known to date.	Cytidine Diphosphate	142-145	cut-like homeobox 2	Mus musculus	20-24
31708105-5	2020	Here we constructed Cux2-mCherry transgenic mice that reproduce the cortical layer II-IV-specific expression of Cux2, a member of the Cut/Cux/CDP family, using BAC transgenesis and a variety of coordinated cortical layer markers that are known to date.	Cytidine Diphosphate	142-145	cut-like homeobox 2	Mus musculus	112-116
31904962-12	2020	HU treatment of the quaternary complex, alpha2/beta2/ATP/CDP, leads to a similar carboxylate shift spectrum, as observed with beta2 alone.	Cytidine Diphosphate	57-60	glycoprotein hormone subunit alpha 2	Homo sapiens	47-52
31904962-12	2020	HU treatment of the quaternary complex, alpha2/beta2/ATP/CDP, leads to a similar carboxylate shift spectrum, as observed with beta2 alone.	Cytidine Diphosphate	57-60	glycoprotein hormone subunit alpha 2	Homo sapiens	126-131
31346358-5	2019	All of the above data implied that CDP exhibited beneficial effects on bone microstructure in ovariectomized rats, and these effects may be related to the NF-kappaB and PI3K/AKT signaling pathways which were triggered by the binding of RANKL, RANK, and TRAF6.	Cytidine Diphosphate	35-38	TNF superfamily member 11	Rattus norvegicus	236-241
31807705-4	2019	Mechanistically, the CDP-Etn pathway inhibits NF-kappaB signaling and mesenchymal genes in a Pebp1-dependent manner, without affecting autophagy, resulting in accelerated mesenchymal-to-epithelial transition (MET) and enhanced reprogramming.	Cytidine Diphosphate	21-24	phosphatidylethanolamine binding protein 1	Homo sapiens	93-98
31637422-1	2019	CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway.	Cytidine Diphosphate	144-147	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	0-44
31637422-1	2019	CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway.	Cytidine Diphosphate	144-147	major facilitator superfamily domain containing 11	Homo sapiens	46-48
31637422-1	2019	CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway.	Cytidine Diphosphate	144-147	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	62-67
31548372-5	2019	Most of the reports on CDPs argue the importance of the spatiotemporal regulation of the initiator caspase, Dronc; however, this sublethal caspase function was independent of Dronc, suggesting a more diverse array of CDP regulatory mechanisms.	Cytidine Diphosphate	23-27	Death regulator Nedd2-like caspase	Drosophila melanogaster	108-113
31548372-5	2019	Most of the reports on CDPs argue the importance of the spatiotemporal regulation of the initiator caspase, Dronc; however, this sublethal caspase function was independent of Dronc, suggesting a more diverse array of CDP regulatory mechanisms.	Cytidine Diphosphate	23-26	Death regulator Nedd2-like caspase	Drosophila melanogaster	108-113
31406378-4	2019	Instead, a +41-kb Irf8 enhancer, previously thought to be active only in plasmacytoid dendritic cells, was found to also be transiently accessible in cDC1 progenitors, and deleting this enhancer prevented the induction of Irf8 in CDPs and abolished cDC1 specification.	Cytidine Diphosphate	230-234	interferon regulatory factor 8	Homo sapiens	18-22
31406378-4	2019	Instead, a +41-kb Irf8 enhancer, previously thought to be active only in plasmacytoid dendritic cells, was found to also be transiently accessible in cDC1 progenitors, and deleting this enhancer prevented the induction of Irf8 in CDPs and abolished cDC1 specification.	Cytidine Diphosphate	230-234	interferon regulatory factor 8	Homo sapiens	222-226
31346358-5	2019	All of the above data implied that CDP exhibited beneficial effects on bone microstructure in ovariectomized rats, and these effects may be related to the NF-kappaB and PI3K/AKT signaling pathways which were triggered by the binding of RANKL, RANK, and TRAF6.	Cytidine Diphosphate	35-38	TNF receptor associated factor 6	Rattus norvegicus	253-258