PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1850968-4	1991	Furthermore, among the oxazine derivatives tested, the derivative with a methyl group at position 3 in an S configuration showed the highest activity against DNA gyrase and derivatives without a methyl group on the oxazine ring were more potent against topoisomerase II than those with a methyl group.	Oxazines	23-30	DNA topoisomerase II alpha	Homo sapiens	158-168
11958285-0	2000	Cytochrome P450 modification by a new oxazine derivative with hypolipidemic activity.	Oxazines	38-45	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
9434598-7	1997	The oxazine alkaloids darrow red, nile blue A, and oxazine 170 are variously effective as inhibitors of cAK, MLCK, PKC, and CDPK (IC50 values 4-65 microM).	Oxazines	4-11	myosin light chain kinase	Rattus norvegicus	109-113
9434598-7	1997	The oxazine alkaloids darrow red, nile blue A, and oxazine 170 are variously effective as inhibitors of cAK, MLCK, PKC, and CDPK (IC50 values 4-65 microM).	Oxazines	51-58	myosin light chain kinase	Rattus norvegicus	109-113
9434598-8	1997	Ca2+ binds to apomorphine and (+)-boldine which, together with nile blue A and oxazine 170, are potent inhibitors of calmodulin (CaM)-dependent MLCK (IC50 values 11, 12, 4, and 7 microM, respectively), and interact with dansyl-CaM.	Oxazines	79-86	myosin light chain kinase	Rattus norvegicus	144-148
18964558-1	1988	The use of oxazine dyes as redox indicators in the determination of uranium(VI), copper(II), osmium(VIII), iridium(IV) and thallium(III) with iron(II) as reductimetric titrant in phosphoric acid medium has been investigated.	Oxazines	11-18	cytochrome c oxidase subunit 8A	Homo sapiens	100-104
31549838-3	2019	Starting with an oxazine lead 1, we describe the discovery of a thiazine-based BACE1 inhibitor 5 with robust Abeta reduction in vivo at low concentrations, leading to a low projected human dose of 14 mg/day where 5 achieved sustained Abeta reduction of 80% at trough level.	Oxazines	17-24	beta-secretase 1	Homo sapiens	79-84
33738048-0	2021	Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors.	Oxazines	6-13	monoglyceride lipase	Homo sapiens	14-37
33738048-0	2021	Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors.	Oxazines	6-13	monoglyceride lipase	Homo sapiens	39-43
32245037-6	2020	A benzoxazine with a phenyl substituent at the 2-position of the oxazine ring is obtained from the 2-((phenylamino)methyl)phenol (hPH-a) and benzaldehyde.	Oxazines	6-13	lamin B receptor	Homo sapiens	130-135
31834986-5	2020	Acridine orange was found to be a MAO-A specific inhibitor (IC50 = 0.017 muM), whereas oxazine 170 is a MAO-B specific inhibitor (IC50 = 0.0065 muM).	Oxazines	87-94	monoamine oxidase B	Homo sapiens	104-109
31834986-5	2020	Acridine orange was found to be a MAO-A specific inhibitor (IC50 = 0.017 muM), whereas oxazine 170 is a MAO-B specific inhibitor (IC50 = 0.0065 muM).	Oxazines	87-94	latexin	Homo sapiens	144-147
29775538-5	2018	Changing to a pyrazine followed by optimization of substituents on both the oxazine and the pyrazine culminated in 24 with robust Abeta reduction in vivo at low doses as well as reduced CYP2D6 inhibition.	Oxazines	76-83	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	186-192
28384360-0	2017	Correction: Novel Synthetic Oxazines Target NF-kappaB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo.	Oxazines	28-36	nuclear factor kappa B subunit 1	Homo sapiens	44-53
29733614-3	2018	Here we describe the discovery and optimization of novel oxazine-based BACE1 inhibitors by lowering amidine basicity with the incorporation of a double bond to improve brain penetration.	Oxazines	57-64	beta-site APP cleaving enzyme 1	Mus musculus	71-76
27482931-3	2016	These chirons were derived from the stereoselective addition of a nucleophile to the corresponding aldehydes of syn,anti-oxazine 10 and syn,syn-oxazine 12.	Oxazines	144-151	synemin	Homo sapiens	136-139
27685808-0	2016	Novel Synthetic Oxazines Target NF-kappaB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo.	Oxazines	16-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-41
27685808-4	2016	Based on the literature on inhibition of NF-kappaB by oxazines, we evaluated the effect of 1,2-oxazines against the ability of NF-kappaB binding to DNA, NF-kappaB-dependent luciferase expression and IkappaBalpha phosphorylation.	Oxazines	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	41-50
27685808-4	2016	Based on the literature on inhibition of NF-kappaB by oxazines, we evaluated the effect of 1,2-oxazines against the ability of NF-kappaB binding to DNA, NF-kappaB-dependent luciferase expression and IkappaBalpha phosphorylation.	Oxazines	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
27685808-4	2016	Based on the literature on inhibition of NF-kappaB by oxazines, we evaluated the effect of 1,2-oxazines against the ability of NF-kappaB binding to DNA, NF-kappaB-dependent luciferase expression and IkappaBalpha phosphorylation.	Oxazines	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
27685808-6	2016	Our in silico analysis revealed the binding of oxazines to the hydrophobic cavity that present between the interface of p65 and IkappaBalpha.	Oxazines	47-55	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	120-123
27685808-6	2016	Our in silico analysis revealed the binding of oxazines to the hydrophobic cavity that present between the interface of p65 and IkappaBalpha.	Oxazines	47-55	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	128-140
27482931-1	2016	This paper describes the stereoselective total syntheses of (+)-1-deoxygalactonojirimycin and (-)-1-deoxygulonojirimycin via new chiral building blocks syn,anti,syn-oxazine 11a and syn,syn,anti-oxazine 13a.	Oxazines	165-172	synemin	Homo sapiens	47-50
27482931-3	2016	These chirons were derived from the stereoselective addition of a nucleophile to the corresponding aldehydes of syn,anti-oxazine 10 and syn,syn-oxazine 12.	Oxazines	144-151	synemin	Homo sapiens	136-139
27482931-4	2016	Furthermore, this paper describes the stereochemical analysis of three types of chiral 1,3-oxazines; anti,syn-, syn,anti-, and syn,syn-oxazines using the NOESY technique.	Oxazines	91-99	synemin	Homo sapiens	106-109
27482931-4	2016	Furthermore, this paper describes the stereochemical analysis of three types of chiral 1,3-oxazines; anti,syn-, syn,anti-, and syn,syn-oxazines using the NOESY technique.	Oxazines	91-99	synemin	Homo sapiens	112-115
27482931-4	2016	Furthermore, this paper describes the stereochemical analysis of three types of chiral 1,3-oxazines; anti,syn-, syn,anti-, and syn,syn-oxazines using the NOESY technique.	Oxazines	91-99	synemin	Homo sapiens	112-115
27482931-4	2016	Furthermore, this paper describes the stereochemical analysis of three types of chiral 1,3-oxazines; anti,syn-, syn,anti-, and syn,syn-oxazines using the NOESY technique.	Oxazines	91-99	synemin	Homo sapiens	112-115
15720749-1	2005	It has been established by combined absorption and fluorescence measurements that the cationic dye Oxazine 1 (OX) and the polyvalent anionic host calix[8]arenesulfonate (SCA8) form two complexes in simultaneous reactions: OX + SCA8 <--> OX.SCA8 (1), and OX.SCA8 + OX <--> OX(2).SCA8 (2).	Oxazines	99-106	ataxin 8	Homo sapiens	170-174
26048794-0	2015	Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.	Oxazines	40-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-113
25309681-3	2014	cDNA-expressed CYP2B6 formed monooxygenated metabolites from EFV analogues containing an intact oxazinone or oxazine ring, but not from analogues with a disrupted ring, suggesting this ring is important for metabolism of EFV by CYP2B6.	Oxazines	109-116	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	15-21
23928160-0	2013	Near-infrared fluorescence glucose sensing based on glucose/galactose-binding protein coupled to 651-Blue Oxazine.	Oxazines	106-113	lectin, galactose binding, soluble 3	Mus musculus	52-85
23928160-5	2013	Fluorescence responses to glucose were preserved when GBP-Blue Oxazine was immobilised to agarose beads, and the beads were excited by NIR light through a mouse skin preparation studied in vitro.	Oxazines	63-70	lectin, galactose binding, soluble 3	Mus musculus	54-57
23928160-6	2013	We conclude GBP-Blue Oxazine shows proof-of-concept as a non-invasive continuous glucose sensing system.	Oxazines	21-28	lectin, galactose binding, soluble 3	Mus musculus	12-15
23590342-2	2013	The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1 inhibitor, was able to reduce significantly CSF Abeta40 and 42 in rats at oral doses as low as 1 mg/kg.	Oxazines	20-27	beta-secretase 1	Rattus norvegicus	68-73
21371450-3	2011	We found that H(2)O(2) triggered a range of cellular cascades which leads to cell death, whereas pretreatment of the cells with this oxazine derivative attenuated the extent of apoptosis, as assessed by MTT assay, acridine orange/ethidium bromide staining and caspase-3 expression assay.	Oxazines	133-140	caspase 3	Rattus norvegicus	260-269
20031407-1	2010	A series of novel oxazolidinone antibiotics having [2.2.1] and [2.2.2] bicyclic oxazine moieties at the C-5 side chain of the A-ring was synthesized by nitroso Diels-Alder reactions, from three linezolid analogs containing morpholine, piperazine and thiomorpholine, respectively, as the C-ring components.	Oxazines	80-87	complement C5	Homo sapiens	104-107
19831345-1	2009	[Ag(COD)(2)]PF(6) catalyzes the reaction between propargyl alcohols and N-tosylaziridines/azetidines leading to a diverse range of N,O-heterocycles, namely, oxazines, oxazepines, and oxazocines via ring-opening and ring-closing in a cascade.	Oxazines	157-165	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	4-7
20831981-0	2010	A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-alpha.	Oxazines	8-15	vascular endothelial growth factor A	Mus musculus	90-94
20831981-0	2010	A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-alpha.	Oxazines	8-15	heparin-binding EGF-like growth factor	Mus musculus	96-102
20831981-0	2010	A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-alpha.	Oxazines	8-15	tumor necrosis factor	Mus musculus	108-117
15720749-1	2005	It has been established by combined absorption and fluorescence measurements that the cationic dye Oxazine 1 (OX) and the polyvalent anionic host calix[8]arenesulfonate (SCA8) form two complexes in simultaneous reactions: OX + SCA8 <--> OX.SCA8 (1), and OX.SCA8 + OX <--> OX(2).SCA8 (2).	Oxazines	99-106	ataxin 8	Homo sapiens	227-231
15720749-1	2005	It has been established by combined absorption and fluorescence measurements that the cationic dye Oxazine 1 (OX) and the polyvalent anionic host calix[8]arenesulfonate (SCA8) form two complexes in simultaneous reactions: OX + SCA8 <--> OX.SCA8 (1), and OX.SCA8 + OX <--> OX(2).SCA8 (2).	Oxazines	99-106	ataxin 8	Homo sapiens	227-231
15720749-1	2005	It has been established by combined absorption and fluorescence measurements that the cationic dye Oxazine 1 (OX) and the polyvalent anionic host calix[8]arenesulfonate (SCA8) form two complexes in simultaneous reactions: OX + SCA8 <--> OX.SCA8 (1), and OX.SCA8 + OX <--> OX(2).SCA8 (2).	Oxazines	99-106	ataxin 8	Homo sapiens	227-231
15720749-1	2005	It has been established by combined absorption and fluorescence measurements that the cationic dye Oxazine 1 (OX) and the polyvalent anionic host calix[8]arenesulfonate (SCA8) form two complexes in simultaneous reactions: OX + SCA8 <--> OX.SCA8 (1), and OX.SCA8 + OX <--> OX(2).SCA8 (2).	Oxazines	99-106	ataxin 8	Homo sapiens	227-231