PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28942022-3 2017 The results showed that the activation of NLRP3 inflammasome was inhibited by X-11-5-27 in a dose-dependent manner, followed by a decrease in the cleavage of caspase-1 and maturation of IL-1beta. x-11 78-82 NLR family pyrin domain containing 3 Homo sapiens 42-47 28942022-9 2017 Moreover, the phosphorylation states of the proteins in PI3K/AKT/mTOR signaling pathway were dramatically decreased after X-11-5-27 treatment. x-11 122-126 AKT serine/threonine kinase 1 Homo sapiens 61-64 28942022-9 2017 Moreover, the phosphorylation states of the proteins in PI3K/AKT/mTOR signaling pathway were dramatically decreased after X-11-5-27 treatment. x-11 122-126 mechanistic target of rapamycin kinase Homo sapiens 65-69