PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26893562-5	2016	The identification of metaphasic nuclei and irregular disposition of beta-actin in the cell cytoplasm supported the hypothesis that citropten conjugated with NDs showed antimitotic properties in B16F10 cells.	5,7-dimethoxycoumarin	132-141	actin, beta	Mus musculus	69-79
29472774-0	2018	5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.	5,7-dimethoxycoumarin	0-21	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	116-137
29472774-0	2018	5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.	5,7-dimethoxycoumarin	0-21	monoamine oxidase A	Rattus norvegicus	156-175
29472774-6	2018	Chronic mild stress induced increase in the monoamine oxidase-A level was inhibited by pre-treatment with 10 mg/kg doses of 5,7-dimethoxycoumarin in the rats.	5,7-dimethoxycoumarin	124-145	monoamine oxidase A	Rattus norvegicus	44-63
29472774-8	2018	The increased level of caspase-3 mRNA and protein level was inhibited by treatment of rats with 5,7-dimethoxycoumarin (10 mg/kg).	5,7-dimethoxycoumarin	96-117	caspase 3	Rattus norvegicus	23-32
29472774-9	2018	5,7-Dimethoxycoumarin administration into the rats caused a marked increase in the levels of heat shock protein-70 mRNA and protein.	5,7-dimethoxycoumarin	0-21	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	93-114
29472774-10	2018	The levels of heat shock protein-70 were markedly lower both in normal and chronic mild stress groups of rats compared to the 5,7-dimethoxycoumarin treated groups.	5,7-dimethoxycoumarin	126-147	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-35
29472774-11	2018	Thus 5,7-dimethoxycoumarin prevented the chronic mild stress induced depression in rats through an increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.	5,7-dimethoxycoumarin	5-26	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	129-150
29472774-11	2018	Thus 5,7-dimethoxycoumarin prevented the chronic mild stress induced depression in rats through an increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels.	5,7-dimethoxycoumarin	5-26	monoamine oxidase A	Rattus norvegicus	169-188
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	107-128	mitogen-activated protein kinase kinase 1	Homo sapiens	13-20
25745781-6	2014	The A-2058 cells were incubated with VPA (1 mM) and DMC (10 muM) for 4 days.	5,7-dimethoxycoumarin	52-55	latexin	Homo sapiens	60-63
21496221-10	2011	CONCLUSIONS: These obtained results clearly indicate that bergapten and citropten are strong inhibitors of IL-8 expression and could be proposed for further studies to verify possible anti-inflammatory properties to reduce lung inflammation in CF patients.	5,7-dimethoxycoumarin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23001511-6	2012	In conjunction with 1 mM VPA, all of the tested concentrations of DMC (10-150 muM) significantly decreased the proliferation of A-375 cells.	5,7-dimethoxycoumarin	66-69	latexin	Homo sapiens	78-81
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	107-128	zinc fingers and homeoboxes 2	Homo sapiens	165-168
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	107-128	mitogen-activated protein kinase kinase 7	Homo sapiens	13-16
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	107-128	mitogen-activated protein kinase 1	Homo sapiens	173-176
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	214-235	mitogen-activated protein kinase kinase 1	Homo sapiens	13-20
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	214-235	zinc fingers and homeoboxes 2	Homo sapiens	165-168
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	214-235	mitogen-activated protein kinase kinase 7	Homo sapiens	13-16
19424591-7	2009	Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment.	5,7-dimethoxycoumarin	214-235	mitogen-activated protein kinase 1	Homo sapiens	173-176
18607531-2	2009	The protein expression of iNOS was screened by Western blot analysis, and four 5,7-dimethoxycoumarins were selected as potent inhibitors of iNOS expression.	5,7-dimethoxycoumarin	79-101	nitric oxide synthase 2, inducible	Mus musculus	26-30
18607531-2	2009	The protein expression of iNOS was screened by Western blot analysis, and four 5,7-dimethoxycoumarins were selected as potent inhibitors of iNOS expression.	5,7-dimethoxycoumarin	79-101	nitric oxide synthase 2, inducible	Mus musculus	140-144