PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
6089236-1	1984	The ability of several calmodulin (CaM) antagonists, such as N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) and trifluoperazine, to displace [3H]-W-7 from CaM correlated with the inhibition of Ca2+-CaM-dependent phosphodiesterase (PDE) by these agents.	W 7	61-112	calmodulin 1	Homo sapiens	23-33
6089236-1	1984	The ability of several calmodulin (CaM) antagonists, such as N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) and trifluoperazine, to displace [3H]-W-7 from CaM correlated with the inhibition of Ca2+-CaM-dependent phosphodiesterase (PDE) by these agents.	W 7	61-112	calmodulin 1	Homo sapiens	35-38
6089236-1	1984	The ability of several calmodulin (CaM) antagonists, such as N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) and trifluoperazine, to displace [3H]-W-7 from CaM correlated with the inhibition of Ca2+-CaM-dependent phosphodiesterase (PDE) by these agents.	W 7	61-112	calmodulin 1	Homo sapiens	166-169
6089236-1	1984	The ability of several calmodulin (CaM) antagonists, such as N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) and trifluoperazine, to displace [3H]-W-7 from CaM correlated with the inhibition of Ca2+-CaM-dependent phosphodiesterase (PDE) by these agents.	W 7	61-112	calmodulin 1	Homo sapiens	166-169
6415064-4	1983	In addition, other calmodulin antagonists, including chlorpromazine, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W7), and N-(6-aminohexyl)-1-naphthalene-sulfonamide (W5), inhibit fusion at doses that correspond closely to the antagonistic effects of these drugs on calmodulin.	W 7	69-120	calmodulin 2	Gallus gallus	274-284
6192958-2	1983	We have investigated the possibility that calmodulin plays a role in immediate hypersensitivity reactions by evaluating the effects of two agents, trifluoperazine dihydrochloride (TFP) and the sulfonamide derivative N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) which selectively bind to calmodulin.	W 7	216-266	calmodulin 1	Homo sapiens	42-52
6192958-2	1983	We have investigated the possibility that calmodulin plays a role in immediate hypersensitivity reactions by evaluating the effects of two agents, trifluoperazine dihydrochloride (TFP) and the sulfonamide derivative N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) which selectively bind to calmodulin.	W 7	268-271	calmodulin 1	Homo sapiens	42-52
6616224-1	1983	The growth inhibitory activity of calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and trifluoperazine (TFP), was analyzed by the use of rat fetal glioblasts stimulated by glia maturation factor (GMF) or rat astrocytoma cells (C6).	W 7	57-107	calmodulin 1	Rattus norvegicus	34-44
6187563-4	1983	The threshold concentration for renin release in the calcium-containing medium was 50 microM for W-7, 5 microM for triflupromazine and 2 microM for trifluoperazine respectively.	W 7	97-100	renin	Rattus norvegicus	32-37
6309563-1	1983	Studies on PGE, TXB2 and O2- production, spreading, and the influence of calmodulin-inhibitor W-7.	W 7	94-97	calmodulin-2	Cavia porcellus	73-83
6309563-6	1983	The calmodulin antagonist W-7 attenuated AGEPC-mediated O2- production and cell spreading whereas prostanoid synthesis was enhanced.	W 7	26-29	calmodulin-2	Cavia porcellus	4-14
6883309-1	1983	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), proved to have antitumor activity against solid Sarcoma-180.	W 7	25-75	calmodulin 2	Mus musculus	2-12
6883309-1	1983	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), proved to have antitumor activity against solid Sarcoma-180.	W 7	77-80	calmodulin 2	Mus musculus	2-12
6403536-3	1983	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide hydrochloride (W-7) (10-100 microM) abolished or suppressed Ca++-stimulated immunoreactive prostaglandin E, labeled arachidonate and prostaglandin release, and the fall in labeled phospholipids but did not suppress labeled diglyceride or inositol accumulation.	W 7	93-96	calmodulin 1	Rattus norvegicus	4-14
6192391-6	1983	A different calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, partially inhibited release while 8-(N,N-diethylamino)-octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8) completely blocked the amylase release induced by the cyclic AMP derivative.	W 7	35-85	calmodulin 1	Rattus norvegicus	12-22
6844347-0	1983	Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor.	W 7	22-25	calmodulin 1	Homo sapiens	0-10
6301535-6	1983	CaM antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), its derivatives, and chlorpromazine and prenylamine inhibited selectively the quinazolinesulfonamide-induced activations of the phosphodiesterase.	W 7	24-74	calmodulin 3	Homo sapiens	0-3
6301535-6	1983	CaM antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), its derivatives, and chlorpromazine and prenylamine inhibited selectively the quinazolinesulfonamide-induced activations of the phosphodiesterase.	W 7	76-79	calmodulin 3	Homo sapiens	0-3
6844347-0	1983	Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor.	W 7	22-25	PCNA clamp associated factor	Homo sapiens	77-103
6844347-2	1983	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a potent calmodulin antagonist, caused dose-dependent inhibition of PAF induced aggregation of human platelets in vitro.	W 7	0-3	calmodulin 1	Homo sapiens	68-78
6844347-2	1983	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a potent calmodulin antagonist, caused dose-dependent inhibition of PAF induced aggregation of human platelets in vitro.	W 7	0-3	PCNA clamp associated factor	Homo sapiens	127-130
6844347-2	1983	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a potent calmodulin antagonist, caused dose-dependent inhibition of PAF induced aggregation of human platelets in vitro.	W 7	5-56	calmodulin 1	Homo sapiens	68-78
6844347-2	1983	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a potent calmodulin antagonist, caused dose-dependent inhibition of PAF induced aggregation of human platelets in vitro.	W 7	5-56	PCNA clamp associated factor	Homo sapiens	127-130
6188646-4	1983	It is concluded that W-7 modulates histamine release by inhibiting some functions of calmodulin in the cells.	W 7	21-24	calmodulin 1	Rattus norvegicus	85-95
6089807-3	1983	The parotid gland calmodulin activated also calmodulin-deficient cyclic nucleotide phosphodiesterase in a Ca2+-dependent fashion, and this activation was abolished by trifluoperazine, W-7 or chlorpromazine.	W 7	184-187	calmodulin	Bos taurus	18-28
6089807-3	1983	The parotid gland calmodulin activated also calmodulin-deficient cyclic nucleotide phosphodiesterase in a Ca2+-dependent fashion, and this activation was abolished by trifluoperazine, W-7 or chlorpromazine.	W 7	184-187	calmodulin	Bos taurus	44-54
6685738-1	1983	Calmodulin was purified from bovine testis and soybean seed, using affinity chromatography on (6-amino-hexyl)-5-chloro-1-naphthylene sulfonamide (W7)-Sepharose.	W 7	146-148	calmodulin	Bos taurus	0-10
6306233-14	1983	The specific calmodulin inhibitors such as chlorpromazine, trifluoperazine and W-7 markedly inhibited lipolysis induced by each agonist.	W 7	79-82	calmodulin 1	Rattus norvegicus	13-23
6622516-1	1983	The effects of calmodulin (CaM) antagonists, N-(6-aminohexyl)(-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives or trifluoperazine (TFP) on the Ca2+ binding to CaM were investigated.	W 7	45-96	calmodulin 1	Homo sapiens	171-174
6201638-6	1983	Ca2+ inhibitors, La3+ and verapamil, and calmodulin inhibitors, trifluoperazine, prenylamine, and W-7, significantly inhibited the release of amylase and sialic acid induced by the stimulants.	W 7	98-101	calmodulin-2	Canis lupus familiaris	41-51
6181205-5	1982	Phosphorylation of MBP in solubilized rat myelin catalyzed by the phospholipid-sensitive enzyme was inhibited by adriamycin, palmitoylcarnitine, trifluoperazine, melittin, polymyxin B, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	189-239	myelin basic protein	Rattus norvegicus	19-22
6982901-5	1982	Trifluoperazine, W-7, cytochalasin D, and taxol also block DNA synthesis in response to EGF as measured by autoradiography using [3H]thymidine.	W 7	17-20	epidermal growth factor	Homo sapiens	88-91
6181205-5	1982	Phosphorylation of MBP in solubilized rat myelin catalyzed by the phospholipid-sensitive enzyme was inhibited by adriamycin, palmitoylcarnitine, trifluoperazine, melittin, polymyxin B, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	241-244	myelin basic protein	Rattus norvegicus	19-22
6897280-7	1982	These results suggest that naphthalenesulfonamide derivatives may be more selective inhibitors of Ca2+, calmodulin-dependent protein phosphorylation than is Ca2+-activated, phospholipid-dependent protein kinase and that the mechanism of interaction between W-7 and phosphatidylserine differs from the interaction between W-7 and calmodulin.	W 7	257-260	calmodulin 1	Homo sapiens	104-114
7146623-1	1982	Chemotaxis and locomotion in rabbit peritoneal granulocytes are strongly inhibited by trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), both known as calmodulin inhibitors.	W 7	106-156	calmodulin	Oryctolagus cuniculus	178-188
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	31-81	calmodulin 1	Homo sapiens	0-10
6254958-6	1980	Moreover, a calmodulin-interacting agent N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide suppressed the TNS fluorescence induced by complex formation with calmodulin in the presence of Ca2+.	W 7	41-91	calmodulin	Bos taurus	12-22
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	31-81	calmodulin 1	Homo sapiens	103-113
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	31-81	calmodulin 1	Homo sapiens	115-118
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	31-81	calmodulin 1	Homo sapiens	168-171
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	83-86	calmodulin 1	Homo sapiens	0-10
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	83-86	calmodulin 1	Homo sapiens	103-113
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	83-86	calmodulin 1	Homo sapiens	115-118
7144734-2	1982	Calmodulin antagonists such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which bind to calmodulin (CaM) in the presence of Ca2+ and selectively inhibit CaM-induced enzyme activation, contain a hydrophobic moiety.	W 7	83-86	calmodulin 1	Homo sapiens	168-171
7085878-5	1982	W-7(10-100 microM) inhibited in a dose-dependent manner platelet aggregation induced by collagen (2 micrograms/ml), ADP (5 microM), epinephrine (1 microgram/ml), sodium arachidonate (0.83 mM), thrombin (0.125 U/ml), and A-23187 (10 microM).	W 7	0-3	coagulation factor II, thrombin	Homo sapiens	193-201
6945588-0	1981	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.	W 7	0-50	LOC100759184	Cricetulus griseus	54-64
6945588-1	1981	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities.	W 7	0-50	LOC100759184	Cricetulus griseus	90-100
6945588-1	1981	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities.	W 7	0-50	LOC100759184	Cricetulus griseus	126-136
6945588-1	1981	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities.	W 7	0-50	LOC100759184	Cricetulus griseus	126-136
6945588-1	1981	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities.	W 7	52-55	LOC100759184	Cricetulus griseus	90-100
6945588-1	1981	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities.	W 7	52-55	LOC100759184	Cricetulus griseus	126-136
6945588-1	1981	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities.	W 7	52-55	LOC100759184	Cricetulus griseus	126-136
6945588-4	1981	N-(6-aminohexyl)-1-naphthalenesulfonamide, an analogue of W-7 that interacts only weakly with calmodulin, proved to be a much weaker inhibitor of cell proliferation.	W 7	58-61	LOC100759184	Cricetulus griseus	94-104
6254958-6	1980	Moreover, a calmodulin-interacting agent N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide suppressed the TNS fluorescence induced by complex formation with calmodulin in the presence of Ca2+.	W 7	41-91	calmodulin	Bos taurus	158-168
32420488-8	2020	We also demonstrated that the myristoylated peptides were more efficient than the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibiting cell migration and equally efficient inhibiting cell proliferation.	W 7	97-147	calmodulin 1	Homo sapiens	82-85
32420488-8	2020	We also demonstrated that the myristoylated peptides were more efficient than the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibiting cell migration and equally efficient inhibiting cell proliferation.	W 7	149-152	calmodulin 1	Homo sapiens	82-85
31415763-8	2019	In addition, BAPTA-AM/W-7 also increased osteoprotegerin-induced activation of Ca2+-NFATc1 signaling, and restored normal P2X7R levels.	W 7	22-25	TNF receptor superfamily member 11b	Homo sapiens	41-56
31415763-8	2019	In addition, BAPTA-AM/W-7 also increased osteoprotegerin-induced activation of Ca2+-NFATc1 signaling, and restored normal P2X7R levels.	W 7	22-25	nuclear factor of activated T cells 1	Homo sapiens	84-90
30233623-5	2018	However, Ca2+ chelators EGTA or BAPTA/AM, Ca2+ channel inhibitors LaCl3 or nifedipine and CaM antagonists W-7 or TFP inhibited the promotion of SNAP.	W 7	106-109	calmodulin 1	Homo sapiens	90-93
29887540-1	2018	We aimed to test whether the calmodulin (CaM) inhibitors, calmidazolium (CZ) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), can be used to assess lipid disorder by flow cytometry using Merocyanine 540 (M540).	W 7	81-131	calmodulin 1	Homo sapiens	29-39
29887540-1	2018	We aimed to test whether the calmodulin (CaM) inhibitors, calmidazolium (CZ) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), can be used to assess lipid disorder by flow cytometry using Merocyanine 540 (M540).	W 7	81-131	calmodulin 1	Homo sapiens	41-44
24599284-11	2014	EGTA, verapamil and the calmodulin inhibitor, W-7, inhibited microparticle generation.	W 7	46-49	calmodulin 1	Homo sapiens	24-34
26969240-8	2016	Furthermore, the SRIF effect was eliminated when the activity of calmodulin (CaM), calcineurin and protein phosphatase 1 (PP1) was blocked with W-7, FK-506 and okadaic acid, respectively.	W 7	144-147	calmodulin 1	Rattus norvegicus	65-75
26969240-8	2016	Furthermore, the SRIF effect was eliminated when the activity of calmodulin (CaM), calcineurin and protein phosphatase 1 (PP1) was blocked with W-7, FK-506 and okadaic acid, respectively.	W 7	144-147	calmodulin 1	Rattus norvegicus	77-80
25617796-1	2015	We investigated the effect of W-7, a calmodulin inhibitor, on voltage-dependent K(+) (Kv) channels in freshly isolated coronary arterial smooth muscle cells using the whole-cell patch clamp technique.	W 7	30-33	calmodulin	Oryctolagus cuniculus	37-47
28825118-6	2017	RESULTS: The L-type Ca2+ channel blockers verapamil and nimodipine, the calmodulin antagonist W-7, and the internal Ca2+ release inhibitor ryanodine all attenuated the antinociceptive effects of 2-BFI.	W 7	94-97	calmodulin 1	Rattus norvegicus	72-82
26984419-10	2016	The ACh-induced inhibition of KNa channel currents was also diminished by the PLC inhibitor U73122 and the calmodulin antagonist W-7.	W 7	129-132	calmodulin 1	Homo sapiens	107-117
26750873-7	2016	Treatment with W7 (a CaM antagonist), KN-93 (a selective inhibitor of CaMKII), and STO 609 (a selective inhibitor of CaMKK) suppressed eNOS phosphorylation and NO production.	W 7	15-17	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	117-122
25069823-7	2015	It was confirmed that a CaM inhibitor, W-7 (50 mum), inhibited PDGF-BB (10 ng mL(-1) )-induced phosphorylation of eEF2K.	W 7	39-42	L1 cell adhesion molecule	Mus musculus	78-84
25069823-7	2015	It was confirmed that a CaM inhibitor, W-7 (50 mum), inhibited PDGF-BB (10 ng mL(-1) )-induced phosphorylation of eEF2K.	W 7	39-42	eukaryotic elongation factor-2 kinase	Rattus norvegicus	114-119
22673522-3	2012	Also, treating cells with the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) enhances the presence of Grb7 in the nucleus.	W 7	45-95	calmodulin 1	Homo sapiens	30-33
24238620-5	2013	W-7 and calmidazolium, antagonists of CaM, as well as KN-93, an inhibitor of CaMKII activity, attenuated ET-1-induced ERK1/2 and PKB phosphorylation.	W 7	0-3	endothelin 1	Homo sapiens	105-109
24238620-5	2013	W-7 and calmidazolium, antagonists of CaM, as well as KN-93, an inhibitor of CaMKII activity, attenuated ET-1-induced ERK1/2 and PKB phosphorylation.	W 7	0-3	mitogen-activated protein kinase 3	Homo sapiens	118-124
24238620-5	2013	W-7 and calmidazolium, antagonists of CaM, as well as KN-93, an inhibitor of CaMKII activity, attenuated ET-1-induced ERK1/2 and PKB phosphorylation.	W 7	0-3	protein tyrosine kinase 2 beta	Homo sapiens	129-132
23838429-9	2013	The calmodulin inhibitor W-7 decreased the proliferation of small SMCs and prevented the large to small phenotypic transition.	W 7	25-28	calmodulin 1	Homo sapiens	4-14
23595906-3	2013	To explore the mechanism of that inhibition, we incubated stallion sperm in media without added calcium, with calcium, or with calcium plus the calmodulin inhibitor W-7 (Ca/W-7 treatment).	W 7	165-168	calmodulin 1	Homo sapiens	144-154
23597509-4	2013	A selective D2R agonist, quinpirole, up-regulated IP3R-1 protein following its mRNA increase, which was significantly inhibited by gallein (a Gbetagamma modulator), U73122 (a phospholipase C inhibitor), BAPTA-AM (an intracellular calcium chelating reagent), W7 (a calmodulin inhibitor), KN-93 (a calmodulin-dependent protein kinases inhibitor), and FK506 (a calcineurin inhibitor).	W 7	258-260	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	50-56
23760276-10	2013	NMR and surface plasmon resonance data show that three CaM antagonists (N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide, tamoxifen, and trifluoperazine) greatly inhibit Fas-CaM interactions by blocking the Fas-binding site on CaM.	W 7	72-123	calmodulin 1	Homo sapiens	55-58
23760276-10	2013	NMR and surface plasmon resonance data show that three CaM antagonists (N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide, tamoxifen, and trifluoperazine) greatly inhibit Fas-CaM interactions by blocking the Fas-binding site on CaM.	W 7	72-123	calmodulin 1	Homo sapiens	177-180
23760276-10	2013	NMR and surface plasmon resonance data show that three CaM antagonists (N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide, tamoxifen, and trifluoperazine) greatly inhibit Fas-CaM interactions by blocking the Fas-binding site on CaM.	W 7	72-123	calmodulin 1	Homo sapiens	177-180
23457304-4	2013	The sustained Akt phosphorylation induced by PDGF-BB was inhibited by pretreatment of the cells with either the intracellular calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis(acetoxymethyl) ester (BAPTA-AM) or the CaM antagonist W7, whereas the transient portion was not inhibited.	W 7	263-265	AKT serine/threonine kinase 1	Homo sapiens	14-17
22535239-9	2013	NaCl- and SA-induced cell death was blocked by Ca(2+) chelator EGTA and calmodulin inhibitor W-7, or with the inhibitors of ROS.	W 7	93-96	calcium-binding protein CP1	Solanum lycopersicum	72-82
23437200-8	2013	Ca(2+)-CaM/VP6 interaction positively regulates RV propagation since both CaM inhibitor (W-7) and Ca(2+) chelator (BAPTA-AM) resulted in decreased viral titers.	W 7	89-92	calmodulin 1	Homo sapiens	7-10
23437200-8	2013	Ca(2+)-CaM/VP6 interaction positively regulates RV propagation since both CaM inhibitor (W-7) and Ca(2+) chelator (BAPTA-AM) resulted in decreased viral titers.	W 7	89-92	calmodulin 1	Homo sapiens	74-77
22933303-7	2012	Moreover, the addition of W-7 (a calmodulin antagonist, 2-4 microM) enhanced the percentages of hyperactivated spermatozoa after incubation with cBiMPS and CaCl(2), independently of protein tyrosine phosphorylation.	W 7	26-29	calmodulin 1	Homo sapiens	33-43
23156733-3	2012	The signal transduction pathways of CGRP were observed by using protein kinase C(PKC) inhibitor (H-7), calmodulin(CaM) inhibitor (W-7) and PKA inhibitor (H-89).	W 7	130-133	calcitonin related polypeptide alpha	Homo sapiens	36-40
22673522-3	2012	Also, treating cells with the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) enhances the presence of Grb7 in the nucleus.	W 7	45-95	growth factor receptor bound protein 7	Homo sapiens	127-131
22673522-3	2012	Also, treating cells with the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) enhances the presence of Grb7 in the nucleus.	W 7	97-100	calmodulin 1	Homo sapiens	30-33
22673522-3	2012	Also, treating cells with the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) enhances the presence of Grb7 in the nucleus.	W 7	97-100	growth factor receptor bound protein 7	Homo sapiens	127-131
22315453-7	2012	The calcium channel antagonist nifedipine and the calmodulin inhibitor W-7 variably inhibited the effect.	W 7	71-74	calmodulin 1	Homo sapiens	50-60
21654199-0	2011	The calmodulin antagonist W-7 inhibits the epithelial Na+/H+ exchanger via modulating membrane surface potential.	W 7	26-29	calmodulin 1	Homo sapiens	4-14
23285183-7	2012	Further more, we document that nNOS denitrosylation could be suppressed by pretreatment of neurons with MK801, an antagonist of NMDAR, GSNO, EGTA, BAPTA, W-7, an inhibitor of calmodulin as well as TrxR1 antisense oligonucleotide (AS-ODN) respectively.	W 7	154-157	nitric oxide synthase 1	Homo sapiens	31-35
21671256-5	2011	When PCP4 expression was induced with doxcycline, neurite outgrowth was significantly advanced in the presence of nerve growth factor (NGF) and dibutyryl cAMP, which was inhibited by W-7, a calmodulin inhibitor, and PD98059, an ERK inhibitor.	W 7	183-186	Purkinje cell protein 4	Rattus norvegicus	5-9
21671256-5	2011	When PCP4 expression was induced with doxcycline, neurite outgrowth was significantly advanced in the presence of nerve growth factor (NGF) and dibutyryl cAMP, which was inhibited by W-7, a calmodulin inhibitor, and PD98059, an ERK inhibitor.	W 7	183-186	nerve growth factor	Rattus norvegicus	114-133
21671256-5	2011	When PCP4 expression was induced with doxcycline, neurite outgrowth was significantly advanced in the presence of nerve growth factor (NGF) and dibutyryl cAMP, which was inhibited by W-7, a calmodulin inhibitor, and PD98059, an ERK inhibitor.	W 7	183-186	nerve growth factor	Rattus norvegicus	135-138
21671256-5	2011	When PCP4 expression was induced with doxcycline, neurite outgrowth was significantly advanced in the presence of nerve growth factor (NGF) and dibutyryl cAMP, which was inhibited by W-7, a calmodulin inhibitor, and PD98059, an ERK inhibitor.	W 7	183-186	Eph receptor B1	Rattus norvegicus	228-231
21251387-0	2011	[Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion].	W 7	12-15	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	37-42
21325494-6	2011	Calmodulin inhibitor W-7 markedly reduced ANG II- and/or dDAVP-stimulated AQP2 expression.	W 7	21-24	calmodulin 2	Mus musculus	0-10
21325494-6	2011	Calmodulin inhibitor W-7 markedly reduced ANG II- and/or dDAVP-stimulated AQP2 expression.	W 7	21-24	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	42-48
21325494-6	2011	Calmodulin inhibitor W-7 markedly reduced ANG II- and/or dDAVP-stimulated AQP2 expression.	W 7	21-24	aquaporin 2	Mus musculus	74-78
20717650-10	2011	Moreover, the CaM inhibitor W-7, significantly decreased Rac1 transamidation in a dose-dependent manner in DOI-treated cells.	W 7	28-31	Rac family small GTPase 1	Homo sapiens	57-61
21251387-1	2011	OBJECTIVE: To investigate the effects of the calmodulin inhibitor W-7 on the expression of the key marker of ERS GRP78 and neuronal apoptosis in the immature rat hippocampus after status convulsion (SC).	W 7	66-69	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	113-118
20599654-2	2010	A fluorescent tracer was newly designed by covalently labeling N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which is a well-known CaM antagonist, with the Cy5 dye.	W 7	63-113	calmodulin 1	Homo sapiens	143-146
20686172-6	2010	The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7, 30 muM) blocked CaCC.	W 7	91-94	chloride channel accessory 3A1	Mus musculus	112-116
20599654-2	2010	A fluorescent tracer was newly designed by covalently labeling N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), which is a well-known CaM antagonist, with the Cy5 dye.	W 7	115-118	calmodulin 1	Homo sapiens	143-146
20599654-3	2010	In the FP assay, the tracer (Cy5-W-7) was bound to CaM with a dissociation constant (K(d)) of 6.5 microM and demonstrated efficient competitive activity with other CaM antagonists, including W-7, chlorpromazine, trifluoperazine, W-5, and clozapine, indicating that Cy5-W-7 binds to the ligand-binding site of CaM in a specific manner.	W 7	33-36	calmodulin 1	Homo sapiens	51-54
20599654-3	2010	In the FP assay, the tracer (Cy5-W-7) was bound to CaM with a dissociation constant (K(d)) of 6.5 microM and demonstrated efficient competitive activity with other CaM antagonists, including W-7, chlorpromazine, trifluoperazine, W-5, and clozapine, indicating that Cy5-W-7 binds to the ligand-binding site of CaM in a specific manner.	W 7	33-36	calmodulin 1	Homo sapiens	164-167
20599654-3	2010	In the FP assay, the tracer (Cy5-W-7) was bound to CaM with a dissociation constant (K(d)) of 6.5 microM and demonstrated efficient competitive activity with other CaM antagonists, including W-7, chlorpromazine, trifluoperazine, W-5, and clozapine, indicating that Cy5-W-7 binds to the ligand-binding site of CaM in a specific manner.	W 7	33-36	calmodulin 1	Homo sapiens	164-167
20702465-3	2010	Furthermore, we showed that the 52-kDa protein kinase has the characteristics of CaM-stimulating activity and is sensitive to calcium-CaM-dependent protein kinase II (CaMK II) inhibitor KN-93 or CaM antagonist W-7.	W 7	210-213	calmodulin	Zea mays	81-84
20860665-1	2010	BACKGROUND AND PURPOSE: N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide (W-7) is a well-known calmodulin inhibitor used to study calmodulin regulation of intracellular Ca(2+) signalling-related process.	W 7	78-81	calmodulin 1	Homo sapiens	99-109
20860665-1	2010	BACKGROUND AND PURPOSE: N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide (W-7) is a well-known calmodulin inhibitor used to study calmodulin regulation of intracellular Ca(2+) signalling-related process.	W 7	78-81	calmodulin 1	Homo sapiens	134-144
20702465-3	2010	Furthermore, we showed that the 52-kDa protein kinase has the characteristics of CaM-stimulating activity and is sensitive to calcium-CaM-dependent protein kinase II (CaMK II) inhibitor KN-93 or CaM antagonist W-7.	W 7	210-213	calmodulin	Zea mays	134-137
20702465-3	2010	Furthermore, we showed that the 52-kDa protein kinase has the characteristics of CaM-stimulating activity and is sensitive to calcium-CaM-dependent protein kinase II (CaMK II) inhibitor KN-93 or CaM antagonist W-7.	W 7	210-213	calmodulin	Zea mays	134-137
19386695-6	2009	Downstream, the transduction pathway likely involves calmodulin because calmodulin antagonists such as W-7 (IC(50) = 2 microM) and fluphenazine (IC(50) = 30 microM) prevented the activation of the W cell by hypoosmotic stimuli.	W 7	103-106	Calmodulin	Drosophila melanogaster	53-63
20363694-0	2010	The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats.	W 7	52-55	calmodulin 1	Rattus norvegicus	59-69
20363694-1	2010	The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration.	W 7	107-110	calmodulin 1	Rattus norvegicus	123-133
20363694-7	2010	In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.	W 7	58-61	calmodulin 1	Rattus norvegicus	131-141
20562516-10	2010	A CaM inhibitor, W-7, and a calcium/CaM-dependent protein kinase type II inhibitor, KN93, inhibited TNF-induced VCAM-1.	W 7	17-20	tumor necrosis factor	Rattus norvegicus	100-103
20562516-10	2010	A CaM inhibitor, W-7, and a calcium/CaM-dependent protein kinase type II inhibitor, KN93, inhibited TNF-induced VCAM-1.	W 7	17-20	vascular cell adhesion molecule 1	Rattus norvegicus	112-118
19853001-7	2009	W7 and BAPTA/AM, a CaM antagonist and an intracellular Ca(2+) chelator, respectively, blocked the rutaecarpine-induced CYP1A1 enzyme activity and mRNA and protein expression.	W 7	0-2	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	119-125
19545622-3	2009	Calmidazolium and W-7, antagonists of CaM, as well as KN-93, a specific inhibitor of CaMKII, attenuated H(2)O(2)-induced responses of ERK1/2 and PKB phosphorylation in a dose-dependent fashion.	W 7	18-21	mitogen-activated protein kinase 3	Homo sapiens	134-140
19194721-7	2009	Application of the calmodulin inhibitor W-7 (10 microM) at normal [Ca(2+)](o) produced a marked decrease of F2, and at low [Ca(2+)](o), a complete blockade of Fe.	W 7	40-43	calmodulin 1	Homo sapiens	19-29
20172594-5	2010	Here we show that CaM antagonists N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W7), tamoxifen (TMX), and trifluoperazine (TFP) induce apoptotic events in human platelets, including depolarization of mitochondrial inner transmembrane potential, caspase-3 activation, and phosphatidylserine exposure.	W 7	34-85	calmodulin 1	Homo sapiens	18-21
20172594-5	2010	Here we show that CaM antagonists N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W7), tamoxifen (TMX), and trifluoperazine (TFP) induce apoptotic events in human platelets, including depolarization of mitochondrial inner transmembrane potential, caspase-3 activation, and phosphatidylserine exposure.	W 7	34-85	caspase 3	Homo sapiens	252-261
19850941-8	2009	Results further show that CaMKII can be activated by Ang II or H(2)O(2), even in the presence of the Ca(2+) chelator BAPTA-AM, in myocytes and in EGTA-Ca(2+)-free solutions in the presence of the calmodulin inhibitor W-7 in in vitro experiments.	W 7	217-220	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	26-32
19850941-8	2009	Results further show that CaMKII can be activated by Ang II or H(2)O(2), even in the presence of the Ca(2+) chelator BAPTA-AM, in myocytes and in EGTA-Ca(2+)-free solutions in the presence of the calmodulin inhibitor W-7 in in vitro experiments.	W 7	217-220	angiotensinogen	Rattus norvegicus	53-59
19789341-7	2009	Exposure to pathway-implicated agents, including the calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, phenothiazine, and chlorpromazine, resulted in rapid apoptotic cell death in high-grade tumor cells resistant to the chemotherapeutic drug cisplatin.	W 7	74-124	calmodulin 1	Homo sapiens	53-63
18587642-12	2009	We found that both Akt and calmodulin translocate to the membrane after EGF-stimulation, and this translocation to the same sub-cellular compartment is inhibited by the calmodulin inhibitor W-7.	W 7	190-193	AKT serine/threonine kinase 1	Homo sapiens	19-22
18587642-12	2009	We found that both Akt and calmodulin translocate to the membrane after EGF-stimulation, and this translocation to the same sub-cellular compartment is inhibited by the calmodulin inhibitor W-7.	W 7	190-193	calmodulin 1	Homo sapiens	27-37
18587642-12	2009	We found that both Akt and calmodulin translocate to the membrane after EGF-stimulation, and this translocation to the same sub-cellular compartment is inhibited by the calmodulin inhibitor W-7.	W 7	190-193	epidermal growth factor	Homo sapiens	72-75
18587642-12	2009	We found that both Akt and calmodulin translocate to the membrane after EGF-stimulation, and this translocation to the same sub-cellular compartment is inhibited by the calmodulin inhibitor W-7.	W 7	190-193	calmodulin 1	Homo sapiens	169-179
19386695-6	2009	Downstream, the transduction pathway likely involves calmodulin because calmodulin antagonists such as W-7 (IC(50) = 2 microM) and fluphenazine (IC(50) = 30 microM) prevented the activation of the W cell by hypoosmotic stimuli.	W 7	103-106	Calmodulin	Drosophila melanogaster	72-82
19269029-3	2009	We observed both short-term and prolonged altered PACAP-mediated activation of the FOS gene in the presence of the calmodulin-antagonist W-7.	W 7	137-140	adenylate cyclase activating polypeptide 1	Homo sapiens	50-55
19269029-3	2009	We observed both short-term and prolonged altered PACAP-mediated activation of the FOS gene in the presence of the calmodulin-antagonist W-7.	W 7	137-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-86
19269029-3	2009	We observed both short-term and prolonged altered PACAP-mediated activation of the FOS gene in the presence of the calmodulin-antagonist W-7.	W 7	137-140	calmodulin 1	Homo sapiens	115-125
19038294-3	2009	Pretreatment with the calmodulin inhibitors W-7 (5 microM) or calmidazolium (5 microM) or with guanylyl cyclase inhibitor LY-83583 (5 microM) completely blocked HFS (20 Hz/20s)-induced gLTP in superior cervical ganglia isolated from normal rats.	W 7	44-47	calmodulin 1	Rattus norvegicus	22-32
19103678-6	2009	Both mitochondrial NO and ROS production were blocked by the nNOS inhibitor (4S)-N-(4-amino-5[aminoethyl]aminopentyl)-N"-nitroguanidine and the calmodulin antagonist W-7, while the eNOS inhibitor L-N(5)-(1-iminoethyl)ornithine (L-NIO) or iNOS inhibitor N-(3-aminomethyl)benzylacetamidine, 2HCl (1400W) had no effect.	W 7	166-169	calmodulin 1	Homo sapiens	144-154
20507535-16	2007	W-7 and chloropromazine, two calmodulin antagonists, also triggered cell death in dnd1-1 and abolished resistance against KACC 10228.	W 7	0-3	Cyclic nucleotide-regulated ion channel family protein	Arabidopsis thaliana	82-86
17098364-1	2007	A sigmoid-type dependence on the inhibitor concentration was observed in the cytochrome c reductase activity for peptide inhibitors (mastoparan and melittin), calmodulin antagonists (W-7 and tamoxifen) and monobutyltin in a reconstituted system comprised of recombinant rat neuronal nitric-oxide synthase (nNOS) and calmodulin (CaM).	W 7	183-186	calmodulin 1	Rattus norvegicus	159-169
17826179-4	2007	The effects of VIP on wound repair of HBEC were partially blocked by H-7 (a protein kinase C (PKC) inhibitor), W-7 (a calmodulin inhibitor), H-89 (a protein kinase A (PKA) inhibitor), and PD98059 (a specific extracellular signal-regulated kinase (ERK) inhibitor).	W 7	111-114	vasoactive intestinal peptide	Homo sapiens	15-18
17220193-12	2007	We conclude that, at certain concentrations, KN-93 selectively inhibits Ca(2+)/CaMKII activity in Xenopus oocytes and that the effects of W-7 are mediated by direct interaction with the channel pore and inhibition of Ca(2+)-CaM, as well as a change in activity of Ca(2+)-CaM-dependent enzymes, including Ca(2+)/CaMKII.	W 7	138-141	calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog	Xenopus laevis	311-317
17227773-0	2007	Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation.	W 7	47-50	epidermal growth factor receptor	Homo sapiens	145-177
17098364-5	2007	Monobutyltin, tamoxifen and W-7 were found to inhibit nNOS activity by binding to the CaM binding site of the nNOS homodimer, in addition to the binding of the inhibitors to calmodulin.	W 7	28-31	nitric oxide synthase 1	Rattus norvegicus	54-58
17098364-5	2007	Monobutyltin, tamoxifen and W-7 were found to inhibit nNOS activity by binding to the CaM binding site of the nNOS homodimer, in addition to the binding of the inhibitors to calmodulin.	W 7	28-31	calmodulin 1	Rattus norvegicus	86-89
17098364-5	2007	Monobutyltin, tamoxifen and W-7 were found to inhibit nNOS activity by binding to the CaM binding site of the nNOS homodimer, in addition to the binding of the inhibitors to calmodulin.	W 7	28-31	nitric oxide synthase 1	Rattus norvegicus	110-114
17098364-5	2007	Monobutyltin, tamoxifen and W-7 were found to inhibit nNOS activity by binding to the CaM binding site of the nNOS homodimer, in addition to the binding of the inhibitors to calmodulin.	W 7	28-31	calmodulin 1	Rattus norvegicus	174-184
17151911-2	2007	Calmodulin antagonists calmidazolium and W-7 prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death, whereas Ca2+ channel blocker nicardipine, mitochondrial Ca2+ uptake inhibitor ruthenium red, and cell permeable Ca2+ chelator BAPTA-AM did not reduce it.	W 7	41-44	calmodulin 1	Rattus norvegicus	0-10
17151911-2	2007	Calmodulin antagonists calmidazolium and W-7 prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death, whereas Ca2+ channel blocker nicardipine, mitochondrial Ca2+ uptake inhibitor ruthenium red, and cell permeable Ca2+ chelator BAPTA-AM did not reduce it.	W 7	41-44	caspase 3	Rattus norvegicus	118-127
16306123-5	2006	CaM antagonists (W-7 and calmidazolium) inhibited mTRPC5 currents when they were applied during the activation of mTRPC5.	W 7	17-20	calmodulin 1	Homo sapiens	0-3
16762411-7	2006	The calmodulin antagonist W-7 and the inhibitor of Ca(2+)-calmodulin dependent protein kinase II (CAMK II) KN-62 removed the glucose transport activation by all the tested stimuli.	W 7	26-29	calmodulin 1	Homo sapiens	4-14
16651714-5	2006	However, the MTP activity was reduced in response to the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7, Ki=25 microM), the intracellular Ca2+ chelator BAPTA-AM, and the extracellular Ca2+ chelator EDTA.	W 7	79-130	microsomal triglyceride transfer protein	Homo sapiens	13-16
16306123-5	2006	CaM antagonists (W-7 and calmidazolium) inhibited mTRPC5 currents when they were applied during the activation of mTRPC5.	W 7	17-20	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	50-56
16306123-5	2006	CaM antagonists (W-7 and calmidazolium) inhibited mTRPC5 currents when they were applied during the activation of mTRPC5.	W 7	17-20	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	114-120
16306123-6	2006	Pretreatment of W-7 and calmidazolium also inhibited the activation of mTRPC5 current.	W 7	16-19	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	71-77
16643366-0	2006	Calmodulin antagonist W-7 prevents sparfloxacin-induced early afterdepolarizations (EADs) in isolated rabbit purkinje fibers: importance of beat-to-beat instability of the repolarization.	W 7	22-25	calmodulin	Oryctolagus cuniculus	0-10
16643366-6	2006	CaM kinase blockade with the calmodulin antagonist W-7 inhibited sparfloxacin-induced EADs in a concentration-dependent manner (EADs were induced in 3 of 10, 1 of 10, and 0 of 8 preparations in the presence of W-7 at 5 x 10(-7) M, 5 x 10(-6) M, and 5 x 10(-5) M, respectively; P < 0.01 at 5 x 10(-6) M and 5 x 10(-5) M).	W 7	51-54	calmodulin	Oryctolagus cuniculus	29-39
16708801-5	2005	The effects were diminished by H-7 and W-7, an antagonist of protein kinase C (PKC) and calmodulin (CaM) (P < 0.01).	W 7	39-42	calmodulin 1	Rattus norvegicus	100-103
16203736-7	2005	The CaM antagonist W-7 decreased both CERK activity and intracellular C1P formation.	W 7	19-22	calmodulin 1	Homo sapiens	4-7
16203736-7	2005	The CaM antagonist W-7 decreased both CERK activity and intracellular C1P formation.	W 7	19-22	ceramide kinase	Homo sapiens	38-42
16407567-10	2006	Furthermore, the BNP effect was abolished after application of the blocker of endoplasmic reticulum Ca2+-ATPase thapsigargin and greatly reduced by the calmodulin inhibitors W-7 and calmidazolium.	W 7	174-177	natriuretic peptide B	Rattus norvegicus	17-20
15701815-7	2005	Two different calmodulin inhibitors (W-7 and trifluoperazine) also blocked the NE-induced Ca(2+) entry.	W 7	37-40	calmodulin 1	Rattus norvegicus	14-24
16144659-4	2005	Calmodulin antagonists (trifluoperazine, W-7 and calmidazolium) had a differential inhibitory effect on the MG132-induced cell death and GSH depletion depending on concentration with a maximal inhibitory effect at 0.5-1 microM.	W 7	41-44	calmodulin 1	Rattus norvegicus	0-10
16144659-8	2005	Trifluoperazine and W-7 at the concentrations of 0.5-1 microM may attenuate the MG132-induced viability loss in PC12 cells by suppressing change in the mitochondrial membrane permeability and by lowering of the intracellular Ca(2+) levels as well as calmodulin inhibition.	W 7	20-23	calmodulin 1	Rattus norvegicus	250-260
16202162-10	2005	Verapamil and W-7, but not BAPTA-AM inhibited the cytoskeletal dysfunctions caused by EC90 or P90.	W 7	14-17	cellular inhibitor of PP2A	Homo sapiens	94-97
16336787-2	2005	Here we show an apoptosis occurred instantly, induced by 300 muM W-7 ((N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride), inhibitor of calmodulin), which demonstrated necrotic modality.	W 7	65-68	calmodulin 1	Homo sapiens	151-161
15735754-8	2005	Specific inhibition of beta-catenin phosphorylation by W-7, a calmodulin inhibitor, or by KN-93, a CaMKII inhibitor, supports these findings whereas PKC inhibitors were without effect.	W 7	55-58	catenin beta 1	Homo sapiens	23-35
15660259-9	2005	Inhibition of the calcium binding proteins calmodulin or calcineurin by W-7 or cyclosporin A, respectively, also prevented the calcium-dependent rapid run-down.	W 7	72-75	calmodulin 1	Homo sapiens	43-53
15932674-1	2005	OBJECTIVE: To evaluate the effects of W-7, a calmodulin inhibitor, on transmural dispersion of repolarization (TDR), early after depolarization (EAD) and torsade de pointes (TdP) induction after administration of d-sotalol in isolated rabbit heart.	W 7	38-41	calmodulin	Oryctolagus cuniculus	45-55
15932674-11	2005	The effects observed with W-7 also suggest a possible important role for calmodulin-activated enzymes in the induction of TdP.	W 7	26-29	calmodulin	Oryctolagus cuniculus	73-83
14567505-6	2003	Pretreatment with Ca2+ chelator EGTA (1 mmol/l), NOS inhibitor L-NAME (300 micromol/l), or calmodulin antagonist W-7 (300 micromol/l) inhibited NO production by EPA (100 micromol/l), but these pretreatments had no effect on ET-1 production by EPA.	W 7	113-116	endothelin 1	Homo sapiens	224-228
15331447-5	2005	Importantly, both the myosin light chain kinase inhibitor wortmannin and the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), caused significant inhibition of 59Fe incorporation from 59Fe-Tf-labeled endosomes into heme, suggesting that myosin is required for Tf-vesicle movement.	W 7	100-151	myosin light chain kinase	Homo sapiens	22-47
15331447-5	2005	Importantly, both the myosin light chain kinase inhibitor wortmannin and the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), caused significant inhibition of 59Fe incorporation from 59Fe-Tf-labeled endosomes into heme, suggesting that myosin is required for Tf-vesicle movement.	W 7	100-151	calmodulin 1	Homo sapiens	77-87
15331447-5	2005	Importantly, both the myosin light chain kinase inhibitor wortmannin and the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), caused significant inhibition of 59Fe incorporation from 59Fe-Tf-labeled endosomes into heme, suggesting that myosin is required for Tf-vesicle movement.	W 7	100-151	myosin heavy chain 14	Homo sapiens	22-28
15331447-5	2005	Importantly, both the myosin light chain kinase inhibitor wortmannin and the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), caused significant inhibition of 59Fe incorporation from 59Fe-Tf-labeled endosomes into heme, suggesting that myosin is required for Tf-vesicle movement.	W 7	153-156	calmodulin 1	Homo sapiens	77-87
15169945-4	2004	During HS at 44 degrees C, calmodulin (CaM) antagonists chlorpromazine (CPZ) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) inhibited DNA-binding activity of the HSF in a concentration-dependent manner, but N-(6-aminohexyl)-1-naphthalenesulfonamide (W5), an inactive structural analogue of W7, did not.	W 7	81-131	calmodulin1	Zea mays	27-37
15169945-4	2004	During HS at 44 degrees C, calmodulin (CaM) antagonists chlorpromazine (CPZ) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) inhibited DNA-binding activity of the HSF in a concentration-dependent manner, but N-(6-aminohexyl)-1-naphthalenesulfonamide (W5), an inactive structural analogue of W7, did not.	W 7	81-131	calmodulin1	Zea mays	39-42
14695278-1	2004	To investigate the interplay between the thin and thick filaments during calcium activation in striated muscle, we employed n-(6-aminohexyl) 5-chloro-1-napthalenesulfonamide (W7) as an inhibitor of troponin C and compared its effects with that of the myosin-specific inhibitor, 2,3-butanedione 2-monoxime (BDM).	W 7	175-177	myosin heavy chain 14	Homo sapiens	251-257
14649722-2	2003	The inhibitory effect of Ca2+/CaM was attenuated by isoquinoline derivatives (PX 28, 34, 216, 224, and CPU57) and a CaM antagonist W-7.	W 7	131-134	calmodulin	Saccharomyces cerevisiae S288C	30-33
14649722-2	2003	The inhibitory effect of Ca2+/CaM was attenuated by isoquinoline derivatives (PX 28, 34, 216, 224, and CPU57) and a CaM antagonist W-7.	W 7	131-134	calmodulin	Saccharomyces cerevisiae S288C	116-119
14500714-5	2003	Correspondingly, the P2X1-induced platelet shape change was inhibited by W-7 and by the MLC kinase inhibitor ML-7 but not by HA-1077.	W 7	73-76	purinergic receptor P2X 1	Homo sapiens	21-25
15627517-3	2005	Calmodulin antagonists (trifluoperazine, W-7 and calmidazolium) at 0.5-1 microM significantly reduced the loss of cell viability in PC12 cells treated with 500 microM MPP+.	W 7	41-44	calmodulin 1	Rattus norvegicus	0-10
14718601-7	2004	The inositol-1,4,5-trisphosphate receptor antagonist 2-aminoethoxy-diphenylborane and the calmodulin inhibitor W-7, but not ryanodine, suppressed both bradykinin- and PGE(2)-evoked responses.	W 7	111-114	calmodulin-2	Cavia porcellus	90-100
12857801-4	2003	The expression of hsp26 and hsp70 genes was up-regulated by the addition of CaCl(2) and down-regulated by the calcium ion chelator EGTA, the calcium ion channel blockers LaCl(3) and verapamil, or the CaM antagonists N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and chlorpromazine.	W 7	216-266	heat shock 70 kDa protein 4	Triticum aestivum	28-33
12451591-7	2003	The calmodulin (CaM) antagonists trifluoperazine (15 microM) and W-7 (50 microM) blocked dephosphorylation of cofilin in stimulated neutrophils whereas inactive/less-active analogs of these inhibitors (15 microM promethazine, 50 microM W-5) were substantially less effective.	W 7	65-68	cofilin 1	Homo sapiens	110-117
12892381-4	2003	The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1).	W 7	155-158	interleukin 1 beta	Rattus norvegicus	24-32
12566122-5	2003	The calmodulin antagonists W-7 (10 microM), calmidazolium (25 microM) and ophiobolin A (20 microM) caused similar reductions in I(f) amplitude (73+/-4, 86+/-9 and 59+/-6% at -80 mV, n=6, 5 and 4, respectively) and shifts in V(h) (11+/-3, 14+/-3 and 8+/-2 mV).	W 7	27-30	calmodulin-3	Cavia porcellus	4-14
12493856-8	2003	Calmodulin or a Ca(2+)-dependent protein kinase is also implicated in the signal transduction sequence, based on the results obtained with two types of calmodulin antagonists, fluphenazine and N-(-6-amino-hexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and staurosporine, an inhibitor of protein kinases.	W 7	248-251	calmodulin	Nicotiana tabacum	0-10
12498925-6	2003	Pretreatment with W-7 (20 microM) potentiated the stimulation of renin release induced by isoproterenol (1 microM).	W 7	18-21	renin	Canis lupus familiaris	65-70
12493856-8	2003	Calmodulin or a Ca(2+)-dependent protein kinase is also implicated in the signal transduction sequence, based on the results obtained with two types of calmodulin antagonists, fluphenazine and N-(-6-amino-hexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and staurosporine, an inhibitor of protein kinases.	W 7	248-251	calmodulin	Nicotiana tabacum	152-162
12020688-4	2002	Pervanadate-induced contractions were reduced by the calmodulin inhibitor W-7 (N-(6-aminohexyl)-chloro-1-naphtalene sulphonamide, 50 microM) and the MLCK inhibitor ML-7 (1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, 10 or 30 microM).	W 7	74-77	calmodulin 1	Rattus norvegicus	53-63
12208465-2	2002	Calmodulin (CaM) antagonists, W-7, trifluoperazine and chlorpromazine, triggered a rise in [Ca(2+)](i) in HUVECs.	W 7	30-33	calmodulin 1	Homo sapiens	12-15
12196518-6	2002	Furthermore, the use of selective CaM antagonists W7 and trifluoperazine maleate resulted in a substantial reduction of the delay period to 200 +/- 100 ms with 5 microm trifluoperazine maleate (n = 16) and 150 +/- 50 ms with 500 nm W7 (n = 22).	W 7	50-52	LOC100759184	Cricetulus griseus	34-37
12063265-6	2002	We report that the calmodulin antagonist W-7 and the calcium/calmodulin-dependent (CaM) kinase inhibitors KN-93 and K252a, can block oxidative stress-induced IkappaB phosphorylation in Jurkat T lymphocytes.	W 7	41-44	calmodulin 1	Homo sapiens	19-29
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	W 7	117-120	calmodulin 1	Homo sapiens	94-104
12196181-5	2002	We found that, in reticulocytes, the myosin light-chain kinase inhibitor, wortmannin, and the calmodulin antagonist, W-7, caused significant inhibition of (59)Fe incorporation from (59)Fe-transferrin-labelled endosomes into haem.	W 7	117-120	transferrin	Homo sapiens	188-199
12007836-7	2002	Blocking calmodulin by W-7 revealed a similar partial inhibition of the stimulatory effect of DALN.	W 7	23-26	calmodulin 2	Mus musculus	9-19
12575328-5	2002	The effect of 3 x 10(-7) mol.L-1 VIP on the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants was inhibited by H-7, a protein kinase C(PKC) inhibitor and W-7, a calmodulin antagonist respectively.	W 7	194-197	vasoactive intestinal peptide	Rattus norvegicus	33-36
11841571-7	2002	CaM inhibitors W-7, ophiobolin A, R-24571 and trifluoperazine, induced a specific dose-dependent inhibition of transport.	W 7	15-18	calmodulin 1	Homo sapiens	0-3
11839636-0	2002	Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.	W 7	21-24	calmodulin	Oryctolagus cuniculus	0-10
11839636-1	2002	BACKGROUND: We have shown that the calmodulin inhibitor W-7 suppresses torsade de pointes (TdP) without shortening the QT interval, which is consistent with other findings that QT prolongation, per se, is insufficient to generate TdP.	W 7	56-59	calmodulin	Oryctolagus cuniculus	35-45
11839636-3	2002	METHODS AND RESULTS: TdP was induced using methoxamine and clofilium in 12 of 14 rabbits pretreated with vehicle control, whereas pretreatment with W-7 (50 micromol/kg), an inhibitor of the intracellular Ca2+-binding protein calmodulin, significantly suppressed TdP induction (1 of 11 rabbits with TdP, P<0.001).	W 7	148-151	calmodulin	Oryctolagus cuniculus	225-235
11942614-3	2001	A Ca2+/CaM inhibitor N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide HCI (W7) inhibits the direct interaction between p85 and Ca2+/CaM.	W 7	21-71	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	121-124
11914123-5	2002	Furthermore, the calmodulin antagonists W-7, trifluoperazine, and J-8 markedly decreased ERK activation.	W 7	40-43	calmodulin 1	Homo sapiens	17-27
11914123-5	2002	Furthermore, the calmodulin antagonists W-7, trifluoperazine, and J-8 markedly decreased ERK activation.	W 7	40-43	mitogen-activated protein kinase 1	Homo sapiens	89-92
11701448-4	2001	Moreover, Ca(2+)-activated pathways seem to be involved, because the calmodulin inhibitor W-7 reduced gastrin-mediated activation of pCRELuc.	W 7	90-93	gastrin	Homo sapiens	102-109
11942614-3	2001	A Ca2+/CaM inhibitor N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide HCI (W7) inhibits the direct interaction between p85 and Ca2+/CaM.	W 7	21-71	calmodulin 1	Homo sapiens	7-10
11942614-3	2001	A Ca2+/CaM inhibitor N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide HCI (W7) inhibits the direct interaction between p85 and Ca2+/CaM.	W 7	21-71	calmodulin 1	Homo sapiens	134-137
11887930-6	2001	W-7, a calmodulin antagonist, reversed both the haloperidol- and oPRL-induced increase in tyrosine hydroxylase activity to control levels.	W 7	0-3	calmodulin 1	Rattus norvegicus	7-17
11748589-4	2001	Furthermore, the calmodulin inhibitors W7 (50 microM) and trifluoperazine (10 microM) and the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62 (2 microM) significantly blocked the volume-activated taurine efflux by 93.4 +/- 2.7, 77.9 +/- 3.5 and 61.3 +/- 15.8%, respectively.	W 7	39-41	calmodulin 1	Homo sapiens	17-27
11441921-10	2001	Calmodulin antagonist W-7.	W 7	22-25	calmodulin 1	Homo sapiens	0-10
11546652-8	2001	On the other hand, W-7, a calmodulin inhibitor, and cyclosporin A, a calcineurin inhibitor, prevented JNK activation by stretch.	W 7	19-22	calmodulin 1	Rattus norvegicus	26-36
11546652-8	2001	On the other hand, W-7, a calmodulin inhibitor, and cyclosporin A, a calcineurin inhibitor, prevented JNK activation by stretch.	W 7	19-22	mitogen-activated protein kinase 8	Rattus norvegicus	102-105
11597928-7	2001	A specific inhibitor for CaM kinase II, KN93, and a calmodulin antagonist, W-7, attenuated eNOS induction by H(2)O(2).	W 7	75-78	nitric oxide synthase 3	Bos taurus	91-95
12580100-7	2001	Specific calmodulin antagonist W-7 was found to significantly inhibit the elevation of calmodulin and CaMK II activity which resulted from DPDPE long-term treatment, and CaMK II inhibitor KN-62 also inhibited elevation of CaMK II activity by DPDPE long-term treatment.	W 7	31-34	calmodulin 2	Mus musculus	9-19
12580100-7	2001	Specific calmodulin antagonist W-7 was found to significantly inhibit the elevation of calmodulin and CaMK II activity which resulted from DPDPE long-term treatment, and CaMK II inhibitor KN-62 also inhibited elevation of CaMK II activity by DPDPE long-term treatment.	W 7	31-34	calmodulin 2	Mus musculus	87-97
12580100-7	2001	Specific calmodulin antagonist W-7 was found to significantly inhibit the elevation of calmodulin and CaMK II activity which resulted from DPDPE long-term treatment, and CaMK II inhibitor KN-62 also inhibited elevation of CaMK II activity by DPDPE long-term treatment.	W 7	31-34	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	102-109
11913468-4	2001	Furthermore, we show that in the case of HeLa cells addition of the calmodulin antagonist W-7 (50 microM) or the calmodulin-dependent kinase II (CaMKII) inhibitor KN-62 (10 microM) reduces the LPC-induced taurine release under isotonic conditions.	W 7	90-93	calmodulin 1	Homo sapiens	68-78
11590224-6	2001	Quin 2-AM and W-7 also inhibited the increase in cAMP content, suggesting that a Ca(2)+/calmodulin-dependent process may be involved in a part of the mechanism in which the receptor antibody and leptin exert their effects.	W 7	14-17	calmodulin 2	Mus musculus	88-98
11590224-6	2001	Quin 2-AM and W-7 also inhibited the increase in cAMP content, suggesting that a Ca(2)+/calmodulin-dependent process may be involved in a part of the mechanism in which the receptor antibody and leptin exert their effects.	W 7	14-17	leptin	Mus musculus	195-201
11396927-4	2001	Similarly, FN-induced enhancement of the scavenger receptor activity assessed by oxLDL uptake was selectively inhibited by Ca(2+) channel blockers (diltiazem, nifedipine, verapamil) and calmodulin inhibitors (W-7, trifluoperazine).	W 7	209-212	fibronectin 1	Mus musculus	11-13
10899954-5	2000	The transient resensitization phase was selectively prevented by deprivation of extracellular Ca(2+) and, even more strikingly, by the presence of W-7 (a CaM antagonist).	W 7	147-150	calmodulin 1	Homo sapiens	154-157
11160327-7	2001	CaM antagonists (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide; trifluoperazine), but not their less-active analogues (N-(6-aminohexyl)-1-naphthalenesulfonamide; promethazine), were also found to block activation of the small GTPases Ras and Rac in stimulated neutrophils along with the extracellular signal-regulated kinases.	W 7	17-67	calmodulin 1	Homo sapiens	0-3
11152392-4	2000	The inhibitory effect of Ca2+/CaM was attenuated by the CaM antagonists W-7, prenylamine and CaM-kinase II fragment (290-309), but not by the calcineurin inhibitor FK506.	W 7	72-75	calmodulin 2	Gallus gallus	30-33
11152392-4	2000	The inhibitory effect of Ca2+/CaM was attenuated by the CaM antagonists W-7, prenylamine and CaM-kinase II fragment (290-309), but not by the calcineurin inhibitor FK506.	W 7	72-75	calmodulin 2	Gallus gallus	56-59
10973964-10	2000	Calmodulin inhibitors (W7 and trifluoperazine) blocked the P(f) response to vasopressin and the vasopressin-stimulated redistribution of aquaporin-2.	W 7	23-25	calmodulin 1	Homo sapiens	0-10
10973964-10	2000	Calmodulin inhibitors (W7 and trifluoperazine) blocked the P(f) response to vasopressin and the vasopressin-stimulated redistribution of aquaporin-2.	W 7	23-25	arginine vasopressin	Homo sapiens	76-87
10973964-10	2000	Calmodulin inhibitors (W7 and trifluoperazine) blocked the P(f) response to vasopressin and the vasopressin-stimulated redistribution of aquaporin-2.	W 7	23-25	arginine vasopressin	Homo sapiens	96-107
10973964-10	2000	Calmodulin inhibitors (W7 and trifluoperazine) blocked the P(f) response to vasopressin and the vasopressin-stimulated redistribution of aquaporin-2.	W 7	23-25	aquaporin 2	Homo sapiens	137-148
11018109-4	2000	Chelation of intracellular calcium with BAPTA-AM or inactivation of calmodulin with W-7 or trifluoperazine reduced the amplitude of depolarization-induced plateau potentials.	W 7	84-87	calmodulin 1	Homo sapiens	68-78
11389972-7	2001	Preincubation with the calmodulin antagonist W-7 almost completely blocked the NO-induced TIF-actin increase and morphological change.	W 7	45-48	calmodulin 2	Mus musculus	23-33
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	W 7	23-74	calmodulin 2	Mus musculus	2-12
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	W 7	23-74	glucagon	Mus musculus	138-143
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	W 7	76-79	calmodulin 2	Mus musculus	2-12
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	W 7	76-79	glucagon	Mus musculus	138-143
11312282-8	2001	However, in the presence of N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide (W-7), SP was no longer able to inhibit the ATP-induced stimulation of mIPSC frequency.	W 7	82-85	tachykinin precursor 1	Homo sapiens	88-90
11121381-7	2001	The calmodulin inhibitors W-7 and calmidazolium attenuate the ACh-induced increase in [Ca(2+)](i) but completely abolish the elevation in CBF.	W 7	26-29	calmodulin 1	Homo sapiens	4-14
11410708-5	2001	It was also reduced in a Ca(2+)-dependent manner by inhibiting CaM with W-7 or calmidazolium.	W 7	72-75	calmodulin 1	Homo sapiens	63-66
11205271-1	2000	The effect of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) (W-7), a widely used calmodulin inhibitor, on intracellular free Ca2+ levels ([Ca2+]i) in bladder female transitional cancer (BFTC) cells was examined using fura-2 as a Ca2+ dye.	W 7	81-84	calmodulin 1	Homo sapiens	101-111
10727421-2	2000	We previously applied this SAXS method to CaM complexed with N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7) [Osawa, Kuwamoto, Izumi, Yap, Ikura, Shibanuma, Yokokura, Hidaka and Matsushima (1999) FEBS Lett.	W 7	61-112	calmodulin 1	Homo sapiens	42-45
10888247-6	2000	The calmodulin-dependent protein kinase II inhibitor KN-93 inhibited the rate of recovery from an acute acid load as did trifluoperazine (TFP) and the calmodulin blocker W7, [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide].	W 7	175-225	calmodulin 1	Homo sapiens	4-14
10888247-6	2000	The calmodulin-dependent protein kinase II inhibitor KN-93 inhibited the rate of recovery from an acute acid load as did trifluoperazine (TFP) and the calmodulin blocker W7, [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide].	W 7	175-225	calmodulin 1	Homo sapiens	151-161
10807662-8	2000	The calmodulin antagonist W-7 and cytochalasin B which enhances actin depolymerization also prevented the effect of CGS 21680; the calmodulin kinase II inhibitors CaM kinase II(281 - 309) and KN-93 but not the inactive structural analogue KN-92 were also effective.	W 7	26-29	calmodulin 1	Rattus norvegicus	4-14
10807662-8	2000	The calmodulin antagonist W-7 and cytochalasin B which enhances actin depolymerization also prevented the effect of CGS 21680; the calmodulin kinase II inhibitors CaM kinase II(281 - 309) and KN-93 but not the inactive structural analogue KN-92 were also effective.	W 7	26-29	calmodulin 1	Rattus norvegicus	131-141
10771092-1	2000	It was investigated why the fMLP-stimulated respiratory burst in human neutrophils was enhanced by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a considered calmodulin antagonist, at lower concentration but inhibited at higher concentration.	W 7	99-149	formyl peptide receptor 1	Homo sapiens	28-32
10771092-1	2000	It was investigated why the fMLP-stimulated respiratory burst in human neutrophils was enhanced by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a considered calmodulin antagonist, at lower concentration but inhibited at higher concentration.	W 7	151-154	formyl peptide receptor 1	Homo sapiens	28-32
11232241-4	2000	Furthermore, different reactions to W-7, a calmodulin inhibitor, were found: W-7 prevented the cell death by each of the three chemicals but not by A23187.	W 7	36-39	Calmodulin	Drosophila melanogaster	43-53
11232241-4	2000	Furthermore, different reactions to W-7, a calmodulin inhibitor, were found: W-7 prevented the cell death by each of the three chemicals but not by A23187.	W 7	77-80	Calmodulin	Drosophila melanogaster	43-53
10590314-3	1999	The presence of W-7 (60 microM), a potent inhibitor of CaM, strongly inhibited the release, while W-5 (60 microM), an inactive CaM antagonist, showed no inhibition.	W 7	16-19	calmodulin 1	Rattus norvegicus	55-58
10817660-7	2000	administration of W-7 (a calmodulin antagonist, 30 microg/rat).	W 7	18-21	calmodulin 1	Rattus norvegicus	25-35
10868934-12	2000	But, exposing them to 0.1 micromol/l n-[6-aminohexyl]-5-chloro-1-naphthalene-sulfonamide, a calmodulin antagonist, resulted in enhanced IP3 response to BK alone to 292.2 +/- 18.5 pmol/mg protein and to BK in the presence of 1, 2, and 20 nmol/l insulin to 488 +/- 22.2, 625.5 +/- 11.6, and 665.2 +/- 15.9 pmol/mg protein, respectively.	W 7	37-88	calmodulin 1	Rattus norvegicus	92-102
10590314-7	1999	cADPR (2 microM)- or ryanodine (500 microM)-induced (45)Ca(2+) release was also inhibited by W-7 (60 microM), but not by W-5 (60 microM), and was stimulated by CaM (10 microg/ml).	W 7	93-96	calmodulin 1	Rattus norvegicus	160-163
10600483-3	1999	The calmodulin antagonists W-7, calmidazolium and fendiline provoked dose-dependent increases in [Ca(2+)](i).	W 7	27-30	calmodulin 1	Homo sapiens	4-14
10600483-5	1999	In the absence of extracellular Ca(2+), pretreatment of cells with bradykinin (BK) and thapsigargin completely prevented W-7-stimulated increase in [Ca(2+)](i).	W 7	121-124	kininogen 1	Homo sapiens	67-77
10600483-5	1999	In the absence of extracellular Ca(2+), pretreatment of cells with bradykinin (BK) and thapsigargin completely prevented W-7-stimulated increase in [Ca(2+)](i).	W 7	121-124	kininogen 1	Homo sapiens	79-81
10622228-5	1999	Additionally, application of the calmodulin inhibitor W-7 (0.01-0.33 nmol) reduced cardiovascular responses to L-arginine (10 nmol) in a dose-dependent manner.	W 7	54-57	calmodulin 1	Rattus norvegicus	33-43
10484429-5	1999	The calmodulin inhibitor W-7 also markedly inhibited BK-induced MAPK phosphorylation in the cytoplasm as well as in the nucleus.	W 7	25-28	calmodulin 1	Homo sapiens	4-14
10484429-5	1999	The calmodulin inhibitor W-7 also markedly inhibited BK-induced MAPK phosphorylation in the cytoplasm as well as in the nucleus.	W 7	25-28	kininogen 1	Homo sapiens	53-55
10384103-5	1999	CI-induced activation was broadly attenuated by the Ca2+ chelating compound EGTA and by calmodulin antagonists trifluoperazine dimaleate and W-7.	W 7	141-144	calmodulin 1	Homo sapiens	88-98
10535305-10	1999	The CaM inhibitor, W-7 (100 microM), and K252-a inhibited Ca2+ oscillations and amylase secretion evoked by CCK-OPE without affecting the AA formation.	W 7	19-22	cholecystokinin	Rattus norvegicus	108-111
10362639-10	1999	The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide inhibited AR42J cell proliferation by 20%, whereas it completely blocked G17 induction of GH3 cell growth.	W 7	25-75	calmodulin 1	Rattus norvegicus	4-14
10567951-7	1999	Furthermore, signal transduction for the regulation of ICAM-1 by PGF2 alpha was investigated using N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7), a calcium calmodulin antagonist, and 1-(5-isoquinolinylsulphonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C (PKC).	W 7	99-150	intercellular adhesion molecule 1	Homo sapiens	55-61
10567951-7	1999	Furthermore, signal transduction for the regulation of ICAM-1 by PGF2 alpha was investigated using N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7), a calcium calmodulin antagonist, and 1-(5-isoquinolinylsulphonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C (PKC).	W 7	152-155	intercellular adhesion molecule 1	Homo sapiens	55-61
9928996-1	1999	Small-angle X-ray scattering and nuclear magnetic resonance were used to investigate the structural change of calcium-bound calmodulin (Ca2+/CaM) in solution upon binding to its antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	190-240	calmodulin 3	Homo sapiens	141-144
10454191-1	1999	During the course of generating derivatives of N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide, a synthetic calmodulin inhibitor, we came across several analogues with shorter alkyl chains that exhibited inhibition of serine/threonine protein kinase activities in an ATP-competitive manner.	W 7	47-98	calmodulin 1	Homo sapiens	112-122
10198335-9	1999	The pp60(c-src) inhibitor herbimycin A (6 microM) inhibited the RhoA band in response to CCK, whereas the calmodulin inhibitor W-7 (100 microM) and the phosphoinositide 3-kinase inhibitor wortmannin (6 microM) had no effect.	W 7	127-130	calmodulin 1	Rattus norvegicus	106-116
10088722-7	1999	The presence of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, reduced the rate of degradation of cAMP formed after PGE2 treatment, suggesting the involvement of calmodulin in the activation of phosphodiesterase.	W 7	16-66	calmodulin 1	Rattus norvegicus	76-86
10088722-7	1999	The presence of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, reduced the rate of degradation of cAMP formed after PGE2 treatment, suggesting the involvement of calmodulin in the activation of phosphodiesterase.	W 7	16-66	calmodulin 1	Rattus norvegicus	198-208
10088722-7	1999	The presence of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, reduced the rate of degradation of cAMP formed after PGE2 treatment, suggesting the involvement of calmodulin in the activation of phosphodiesterase.	W 7	68-71	calmodulin 1	Rattus norvegicus	76-86
10088722-7	1999	The presence of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, reduced the rate of degradation of cAMP formed after PGE2 treatment, suggesting the involvement of calmodulin in the activation of phosphodiesterase.	W 7	68-71	calmodulin 1	Rattus norvegicus	198-208
9928996-1	1999	Small-angle X-ray scattering and nuclear magnetic resonance were used to investigate the structural change of calcium-bound calmodulin (Ca2+/CaM) in solution upon binding to its antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	242-245	calmodulin 3	Homo sapiens	141-144
9879721-1	1998	We have recently shown that spinal calmodulin inhibitors (W-7 and calmidazolium) dose-dependently inhibit the nociceptive reaction (biting, scratching, licking, BSL) evoked by intrathecal N-methyl-D-aspartate (NMDA) and septide, an agonist of the neurokinin (NK) NK1 receptor.	W 7	58-61	calmodulin 1	Homo sapiens	35-45
10096470-3	1999	On the other hand, intravesicular Ca2+, up to about 10 microM, inhibited the GABA uptake (approximately 50%) in a manner which appeared to be facilitated in the presence of PP1 and PP2A inhibitors and this inhibition was relieved by the calmodulin antagonist W-7.	W 7	259-262	inorganic pyrophosphatase 1	Homo sapiens	173-176
10096470-3	1999	On the other hand, intravesicular Ca2+, up to about 10 microM, inhibited the GABA uptake (approximately 50%) in a manner which appeared to be facilitated in the presence of PP1 and PP2A inhibitors and this inhibition was relieved by the calmodulin antagonist W-7.	W 7	259-262	protein phosphatase 2 phosphatase activator	Homo sapiens	181-185
9879721-1	1998	We have recently shown that spinal calmodulin inhibitors (W-7 and calmidazolium) dose-dependently inhibit the nociceptive reaction (biting, scratching, licking, BSL) evoked by intrathecal N-methyl-D-aspartate (NMDA) and septide, an agonist of the neurokinin (NK) NK1 receptor.	W 7	58-61	tachykinin receptor 1	Homo sapiens	263-275
10343772-8	1998	Adhesion to fibronectin of cells from grossly intact cartilage was decreased by the addition of PKC and calmodulin-dependent kinase inhibitors, W7 and sphingosine, to the cell culture.	W 7	144-146	fibronectin 1	Homo sapiens	12-23
9792538-8	1998	The calmodulin inhibitor W-7 and the myosin light-chain kinase inhibitor ML-9 decreased the motile events in the beta-cells under both nonstimulated and acetylcholine-stimulated conditions.	W 7	25-28	calmodulin 2	Mus musculus	4-14
9774361-5	1998	Calmodulin inhibitors (W7 and calmidazolium) and tyrosine kinase inhibitors (genistein and ST638) completely blocked ERK activation by Ang II and A23187.	W 7	23-25	calmodulin 1	Homo sapiens	0-10
9774361-5	1998	Calmodulin inhibitors (W7 and calmidazolium) and tyrosine kinase inhibitors (genistein and ST638) completely blocked ERK activation by Ang II and A23187.	W 7	23-25	mitogen-activated protein kinase 1	Homo sapiens	117-120
9774361-5	1998	Calmodulin inhibitors (W7 and calmidazolium) and tyrosine kinase inhibitors (genistein and ST638) completely blocked ERK activation by Ang II and A23187.	W 7	23-25	angiotensinogen	Homo sapiens	135-141
9703212-11	1998	The calmodulin antagonist W-7 (100 microM) reduced, in a reversible manner, both components of NA-induced response.	W 7	26-29	calmodulin 1	Homo sapiens	4-14
9665388-9	1998	Both the differentiation and the apoptotic processes appeared to be calmodulin dependent, because the calmodulin inhibitor W-7 blocked the expression of the differentiation-specific markers, as well as the apoptotic response, in a concentration-dependent fashion.	W 7	123-126	calmodulin 1	Homo sapiens	68-78
9665388-9	1998	Both the differentiation and the apoptotic processes appeared to be calmodulin dependent, because the calmodulin inhibitor W-7 blocked the expression of the differentiation-specific markers, as well as the apoptotic response, in a concentration-dependent fashion.	W 7	123-126	calmodulin 1	Homo sapiens	102-112
9489023-5	1998	CDPK exhibits a Ca(2+)-induced electrophoretic mobility shift and its Ca(2+)-dependent catalytic activity can be inhibited by the calmodulin antagonists trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide.	W 7	173-223	calcium-dependent protein kinase 1	Glycine max	0-4
9596720-7	1998	The inhibitory assay suggested that butyric acid-induced apoptosis of WEHI 231 and splenic B cells was inhibited by W-7, a calmodulin inhibitor.	W 7	116-119	calmodulin 2	Mus musculus	123-133
9492304-1	1998	The treatment of human uterine cervical fibroblasts with concanavalin A (ConA), or a specific calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) or trifluoperazine resulted in accumulation of an active form of matrix metalloproteinase 2 (MMP-2, gelatinase A).	W 7	117-167	calmodulin 1	Homo sapiens	94-104
9492304-1	1998	The treatment of human uterine cervical fibroblasts with concanavalin A (ConA), or a specific calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) or trifluoperazine resulted in accumulation of an active form of matrix metalloproteinase 2 (MMP-2, gelatinase A).	W 7	117-167	matrix metallopeptidase 2	Homo sapiens	239-265
9492304-1	1998	The treatment of human uterine cervical fibroblasts with concanavalin A (ConA), or a specific calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) or trifluoperazine resulted in accumulation of an active form of matrix metalloproteinase 2 (MMP-2, gelatinase A).	W 7	117-167	matrix metallopeptidase 2	Homo sapiens	267-272
9435158-8	1998	Furthermore, W-7 (a calmodulin antagonist) completely abolished the effects of roxatidine on mucus secretion and synthesis without causing a reduction of the stimulated Ca++ influx.	W 7	13-16	calmodulin	Oryctolagus cuniculus	20-30
9929743-8	1998	However, this PMA response was strongly inhibited by calmodulin antagonists (chlorpromazine, trifluoperazine, W-7) and the calcium blocker verapamil.	W 7	110-113	calmodulin 2	Mus musculus	53-63
9457477-8	1998	The calmodulin inhibitor W-7 (1-100 microM) relaxed, in a concentration-dependent way, the vanadate contraction (EC50:67.0 +/- 18 microM).	W 7	25-28	calmodulin 1	Rattus norvegicus	4-14
9314839-5	1997	Consistent with a role for Ca2+ and calmodulin in intracellular Ca(2+)-induced activation of ERK, cells pretreated with calmodulin inhibitors (W-7 or calmidazolium) exhibited an attenuated ERK response to ionomycin.	W 7	143-146	mitogen activated protein kinase 3	Rattus norvegicus	93-96
9314839-5	1997	Consistent with a role for Ca2+ and calmodulin in intracellular Ca(2+)-induced activation of ERK, cells pretreated with calmodulin inhibitors (W-7 or calmidazolium) exhibited an attenuated ERK response to ionomycin.	W 7	143-146	mitogen activated protein kinase 3	Rattus norvegicus	189-192
9202183-4	1997	Nevertheless, trifluoperazine and n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide inhibited the plasma-membrane Ca2+ ATPase if added to plasma membrane-enriched fractions of neutrophils.	W 7	34-84	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	99-126
9268690-4	1997	Previous reports have shown that verapamil and W-7, both of which block voltage gated calcium channels and inhibit the activation of cytosolic calmodulin, respectively, blocked capacitively coupled electric field-induced proliferation of the osteoblast cells.	W 7	47-50	calmodulin 1	Homo sapiens	143-153
9268690-5	1997	Interestingly, we found that verapamil and W-7 can also block capacitively coupled electric field-induced elevation of TGF-beta1 mRNA.	W 7	43-46	transforming growth factor beta 1	Homo sapiens	119-128
9460910-5	1997	Using the calmodulin inhibitor W-7 we found a significant (p < 0.05) decrease in the percentage of oocytes that underwent germinal vesicle breakdown.	W 7	31-34	calmodulin	Oryctolagus cuniculus	10-20
9310945-1	1997	Treating the mouse intestine with the calmodulin antagonist W-7 and KN-93, an inhibitor of Ca(2+)-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat-stable enterotoxin II (STII).	W 7	60-63	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	91-136
9138096-5	1997	This effect was reversed by the Ca(++) channel blocker, verapamil, and the Ca(++)/calmodulin inhibitor, W-7.	W 7	104-107	calmodulin 1	Homo sapiens	82-92
9120579-7	1997	The high-affinity calmodulin inhibitor N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonomide hydrochloride (W-7) (5 microM) completely blocked, whereas the low-affinity calmodulin inhibitor N-(6-aminohexyl)-1-naphthalenesulfonomide hydrochloride (W-5) (50 microM) did not affect, the hypoxic hyperpolarization.	W 7	106-109	calmodulin 1	Rattus norvegicus	18-28
9120579-7	1997	The high-affinity calmodulin inhibitor N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonomide hydrochloride (W-7) (5 microM) completely blocked, whereas the low-affinity calmodulin inhibitor N-(6-aminohexyl)-1-naphthalenesulfonomide hydrochloride (W-5) (50 microM) did not affect, the hypoxic hyperpolarization.	W 7	106-109	calmodulin 1	Rattus norvegicus	167-177
8954918-5	1996	Previous reports have shown that neomycin and W-7, which are inhibitors in the inositol phosphate/calmodulin pathway, blocked mechanical strain-induced proliferation of the osteoblast cells.	W 7	46-49	calmodulin 2	Mus musculus	98-108
8954918-6	1996	Interestingly, we found that neomycin and W-7 can also block mechanical stimulation-induced elevation of TGF-beta 1 mRNA.	W 7	42-45	transforming growth factor, beta 1	Mus musculus	105-115
9050450-1	1997	The effects of the calmodulin antagonists W-7 and trifluoperazine have been measured on the Ca2+-activated potassium channel in the membrane surrounding protoplasmic drops expressed from internodal cells of charophyte plants.	W 7	42-45	calmodulin 1	Homo sapiens	19-29
9310945-1	1997	Treating the mouse intestine with the calmodulin antagonist W-7 and KN-93, an inhibitor of Ca(2+)-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat-stable enterotoxin II (STII).	W 7	60-63	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	138-145
8989881-6	1996	The calmodulin antagonists trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide inhibited both external Ca(2+)-supported and acetate-supported induction.	W 7	47-97	uncharacterized protein	Chlamydomonas reinhardtii	4-14
8913880-11	1996	The calmodulin inhibitor W-7 (50 microM) drastically reduced the bradykinin- and ionomycin-induced arachidonic acid release.	W 7	25-28	calmodulin	Bos taurus	4-14
8913880-11	1996	The calmodulin inhibitor W-7 (50 microM) drastically reduced the bradykinin- and ionomycin-induced arachidonic acid release.	W 7	25-28	kininogen 1	Bos taurus	65-75
8945910-7	1996	Calmodulin antagonists W-7 and calmidazolium, as well as Ca2+/calmodulin-dependent kinase II inhibitor KN-62, significantly reduced thrombin-induced preproET-1 mRNA.	W 7	23-26	calmodulin 1	Homo sapiens	0-10
8945910-7	1996	Calmodulin antagonists W-7 and calmidazolium, as well as Ca2+/calmodulin-dependent kinase II inhibitor KN-62, significantly reduced thrombin-induced preproET-1 mRNA.	W 7	23-26	coagulation factor II, thrombin	Homo sapiens	132-140
9001889-3	1996	The protein kinase C inhibitors, H-7 and staurosporine, and downregulation of protein kinase C could not inhibit prostaglandin E2 production, while W-7, a calmodulin inhibitor, abolished it.	W 7	148-151	calmodulin 1	Rattus norvegicus	155-165
8908595-4	1996	The calmodulin inhibitor W-7 and the protein kinase C inhibitor chelerythrine also blocked MeWo adhesion stabilization to fibronectin, as did the tyrosine kinase inhibitor genistein and the cytoskeletal inhibitor cytochalasin D.	W 7	25-28	fibronectin 1	Homo sapiens	122-133
8798734-7	1996	The calmodulin antagonists W-7 and trifluoperazine inhibited Abeta formation and enhanced the action of PKC in both the cell-free system and intact cells.	W 7	27-30	calmodulin 1	Homo sapiens	4-14
8831568-2	1996	The calmodulin antagonists trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) stimulated apical endocytosis of ricin, whereas basolateral endocytosis was unaffected.	W 7	47-97	calmodulin-2	Canis lupus familiaris	4-14
8831568-2	1996	The calmodulin antagonists trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) stimulated apical endocytosis of ricin, whereas basolateral endocytosis was unaffected.	W 7	99-102	calmodulin-2	Canis lupus familiaris	4-14
8831568-5	1996	Transport of ricin to the Golgi apparatus was also selectively affected by the calmodulin antagonist W-7.	W 7	101-104	calmodulin-2	Canis lupus familiaris	79-89
8822043-9	1996	This activity was inhibited by N-monomethyl-L-arginine (NMMA), nitroarginine, N-6-aminohexyl-5-chloro-1-napthalene sulfonamide (W-7), a calmodulin antagonist, suggesting that the nitric oxide synthase activity is calmodulin dependent.	W 7	128-131	calmodulin 1	Rattus norvegicus	136-146
8938986-3	1996	Both cytochalasin D, an inhibitor of microfilament formation, and W7, an inhibitor of calmodulin, inhibited capping of CD3.	W 7	66-68	CD3 antigen, epsilon polypeptide	Mus musculus	119-122
8756293-9	1996	Morulae exposed to the calmodulin inhibitor W-7 exhibited a dose-dependent delay in blastocoel formation.	W 7	44-47	calmodulin 2	Mus musculus	23-33
8870433-6	1996	Galvanotropic and galvanotaxic cellular movements were inhibited by cytochalasin D (0.1-0.5 microgram/mL) and the calmodulin antagonist, W-7 (80 mumol/L).	W 7	137-140	calmodulin	Oryctolagus cuniculus	114-124
8829112-7	1996	Moreover, the calmodulin inhibitors calmidazolium (10 uM), trifluoperazine (0.1 mM), or W-7 (0.1 mM) significantly inhibited AngII- or ionomycin-activated iCRAC (+106 +/- 38/229 +/- 53, +58 +/- 9/195 +/- 29, +161 +/- 38/180 +/- 40% at 1/10 mM (Ca2+)e, all P < 0.05), but did not affect basal Ca2+ entry, consistent with a direct role of cytoplasmic Ca2+ in the regulation of ion gating.	W 7	88-91	calmodulin 1	Homo sapiens	14-24
8829112-7	1996	Moreover, the calmodulin inhibitors calmidazolium (10 uM), trifluoperazine (0.1 mM), or W-7 (0.1 mM) significantly inhibited AngII- or ionomycin-activated iCRAC (+106 +/- 38/229 +/- 53, +58 +/- 9/195 +/- 29, +161 +/- 38/180 +/- 40% at 1/10 mM (Ca2+)e, all P < 0.05), but did not affect basal Ca2+ entry, consistent with a direct role of cytoplasmic Ca2+ in the regulation of ion gating.	W 7	88-91	angiotensinogen	Homo sapiens	125-130
8653710-7	1996	The transcriptional inhibitor actinomycin D, various protein kinase C inhibitors, and the calmodulin inhibitor W-7 strongly reduced PRG1 induction by PACAP, whereas the translational inhibitor cycloheximide potently increased PRG1 mRNA levels in unstimulated and PACAP-stimulated cells.	W 7	111-114	calmodulin 1	Rattus norvegicus	90-100
8653710-7	1996	The transcriptional inhibitor actinomycin D, various protein kinase C inhibitors, and the calmodulin inhibitor W-7 strongly reduced PRG1 induction by PACAP, whereas the translational inhibitor cycloheximide potently increased PRG1 mRNA levels in unstimulated and PACAP-stimulated cells.	W 7	111-114	immediate early response 3	Rattus norvegicus	132-136
8653710-7	1996	The transcriptional inhibitor actinomycin D, various protein kinase C inhibitors, and the calmodulin inhibitor W-7 strongly reduced PRG1 induction by PACAP, whereas the translational inhibitor cycloheximide potently increased PRG1 mRNA levels in unstimulated and PACAP-stimulated cells.	W 7	111-114	adenylate cyclase activating polypeptide 1	Rattus norvegicus	150-155
8653710-7	1996	The transcriptional inhibitor actinomycin D, various protein kinase C inhibitors, and the calmodulin inhibitor W-7 strongly reduced PRG1 induction by PACAP, whereas the translational inhibitor cycloheximide potently increased PRG1 mRNA levels in unstimulated and PACAP-stimulated cells.	W 7	111-114	immediate early response 3	Rattus norvegicus	226-230
8653710-7	1996	The transcriptional inhibitor actinomycin D, various protein kinase C inhibitors, and the calmodulin inhibitor W-7 strongly reduced PRG1 induction by PACAP, whereas the translational inhibitor cycloheximide potently increased PRG1 mRNA levels in unstimulated and PACAP-stimulated cells.	W 7	111-114	adenylate cyclase activating polypeptide 1	Rattus norvegicus	263-268
9240763-13	1996	Calmodulin (CaM) inhibitors, trifluoperazine and W-7, inhibited the actions of insulin more than 90%.	W 7	49-52	insulin	Oryctolagus cuniculus	79-86
9011614-11	1996	The effect of aldosterone upon pHi and setpoint was also prevented by the calcium-calmodulin antagonist, W-7.	W 7	105-108	calmodulin 1	Homo sapiens	82-92
8750956-8	1995	Calmodulin antagonists, W-7 (100 microM) and trifluoperazine (10 microM), were also effective, although at concentrations well above those required to inhibit calmodulin.	W 7	24-27	calmodulin 2	Mus musculus	0-10
8750956-8	1995	Calmodulin antagonists, W-7 (100 microM) and trifluoperazine (10 microM), were also effective, although at concentrations well above those required to inhibit calmodulin.	W 7	24-27	calmodulin 2	Mus musculus	159-169
8565149-4	1995	Liberation of arachidonic acid by bradykinin and ATP was reduced by mepacrine, a blocker of phospholipase A2 and W-7, a calmodulin antagonist.	W 7	113-116	kininogen 1	Homo sapiens	34-44
8964090-8	1996	Calmodulin antagonists W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalene-sulfonamide) and mellitin inhibited serotonin uptake in K562 cells, suggesting that CaM is involved in serotonin transport regulation.	W 7	23-26	calmodulin 1	Homo sapiens	0-10
8964090-8	1996	Calmodulin antagonists W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalene-sulfonamide) and mellitin inhibited serotonin uptake in K562 cells, suggesting that CaM is involved in serotonin transport regulation.	W 7	28-79	calmodulin 1	Homo sapiens	0-10
8964090-8	1996	Calmodulin antagonists W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalene-sulfonamide) and mellitin inhibited serotonin uptake in K562 cells, suggesting that CaM is involved in serotonin transport regulation.	W 7	28-79	calmodulin 1	Homo sapiens	152-155
8909975-3	1996	The phasic contraction was markedly suppressed by calmodulin antagonist W-7, but not by protein kinase C inhibitor H-7.	W 7	72-75	calmodulin-3	Cavia porcellus	50-60
8702861-6	1996	Exposure of cultured A-10 muscle cells to three structurally disparate calmodulin antagonists (W-7, trifluoperazine, and calmidazolium) resulted in the robust release of arachidonic acid, which was entirely ablated by pretreatment of cells with (E)-6-(bromomethylene)-3-(1-naphthalenyl)-2-H-tetrahydropyran-2-one.	W 7	95-98	calmodulin 1	Homo sapiens	71-81
8760044-11	1996	The stimulation of Ca2+ uptake was inhibited by including the SR Ca2+ pump inhibitors thapsigargin and cyclopiazonic acid in the Ca2+ uptake medium or by including the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide or the calmodulin kinase II peptide fragment 290-309 in the phosphorylation solution.	W 7	190-240	calmodulin-3	Sus scrofa	168-178
8799482-3	1996	When inhibitors of protein kinases were exogenously added to the homogenates from either the CCl4-administered group or the G-Rb1 plus CCl4-administered group, their phosphorylations were inhibited much more by W-7, an inhibitor of Ca2+/calmodulin-dependent protein kinase (CaM-PK), than by H-7, an inhibitor of protein kinase C (C-kinase).	W 7	211-214	C-C motif chemokine ligand 4	Rattus norvegicus	93-97
8799482-3	1996	When inhibitors of protein kinases were exogenously added to the homogenates from either the CCl4-administered group or the G-Rb1 plus CCl4-administered group, their phosphorylations were inhibited much more by W-7, an inhibitor of Ca2+/calmodulin-dependent protein kinase (CaM-PK), than by H-7, an inhibitor of protein kinase C (C-kinase).	W 7	211-214	RB transcriptional corepressor 1	Rattus norvegicus	126-129
8799482-3	1996	When inhibitors of protein kinases were exogenously added to the homogenates from either the CCl4-administered group or the G-Rb1 plus CCl4-administered group, their phosphorylations were inhibited much more by W-7, an inhibitor of Ca2+/calmodulin-dependent protein kinase (CaM-PK), than by H-7, an inhibitor of protein kinase C (C-kinase).	W 7	211-214	C-C motif chemokine ligand 4	Rattus norvegicus	135-139
8721674-7	1996	ET-3 stimulated stress fiber formation in stellate astrocytes induced by 50 microM ML-9, 20 microM W-7, and 5 microM cytochalasin B (CB).	W 7	99-102	endothelin 3	Rattus norvegicus	0-4
8611631-6	1996	Treatment with TNF-alpha for 4-24 h increased the cPLA2 protein and mRNA levels which were blocked by the broad inhibitor of protein kinases staurosporine, the protein kinase C (PKC) inhibitor calphostin C, and to a lesser extent the calcium/calmodulin-dependent protein kinase inhibitor W-7.	W 7	288-291	tumor necrosis factor	Homo sapiens	15-24
8611631-6	1996	Treatment with TNF-alpha for 4-24 h increased the cPLA2 protein and mRNA levels which were blocked by the broad inhibitor of protein kinases staurosporine, the protein kinase C (PKC) inhibitor calphostin C, and to a lesser extent the calcium/calmodulin-dependent protein kinase inhibitor W-7.	W 7	288-291	phospholipase A2 group IVA	Homo sapiens	50-55
8723030-5	1996	The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide partially inhibited AIB uptake in response to AII, suggesting that calmodulin may be involved in the modulation of AII-stimulated amino acid transport.	W 7	25-75	calmodulin 1	Homo sapiens	4-14
8723030-5	1996	The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide partially inhibited AIB uptake in response to AII, suggesting that calmodulin may be involved in the modulation of AII-stimulated amino acid transport.	W 7	25-75	angiotensinogen	Homo sapiens	122-125
8723030-5	1996	The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide partially inhibited AIB uptake in response to AII, suggesting that calmodulin may be involved in the modulation of AII-stimulated amino acid transport.	W 7	25-75	calmodulin 1	Homo sapiens	143-153
8723030-5	1996	The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide partially inhibited AIB uptake in response to AII, suggesting that calmodulin may be involved in the modulation of AII-stimulated amino acid transport.	W 7	25-75	angiotensinogen	Homo sapiens	191-194
8541554-6	1995	Calmodulin antagonists (calmidazolium and W-7) caused up to 80% inhibition of MBP-stimulated O2- production.	W 7	42-45	calmodulin 1	Homo sapiens	0-10
8541554-6	1995	Calmodulin antagonists (calmidazolium and W-7) caused up to 80% inhibition of MBP-stimulated O2- production.	W 7	42-45	myelin basic protein	Homo sapiens	78-81
8822043-9	1996	This activity was inhibited by N-monomethyl-L-arginine (NMMA), nitroarginine, N-6-aminohexyl-5-chloro-1-napthalene sulfonamide (W-7), a calmodulin antagonist, suggesting that the nitric oxide synthase activity is calmodulin dependent.	W 7	128-131	calmodulin 1	Rattus norvegicus	213-223
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	W 7	26-76	calmodulin 2	Mus musculus	4-14
8720130-4	1995	We also demonstrated that calmodulin inhibitors, chlorpromazine and W-7, could suppress the DNA fragmentation.	W 7	68-71	calmodulin 1	Rattus norvegicus	26-36
8590977-10	1995	As for calmodulin antagonists, W-7 (100 microM), but not calmidazolium (1 microM), reduced the K+ current.	W 7	31-34	calmodulin 1	Rattus norvegicus	7-17
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	W 7	26-76	FBJ osteosarcoma oncogene	Mus musculus	194-199
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	W 7	78-81	calmodulin 2	Mus musculus	4-14
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	W 7	78-81	FBJ osteosarcoma oncogene	Mus musculus	194-199
7561871-9	1995	In the animals treated with W-7 before kainic acid or NMDA administration, c-fos expression was inhibited in cerebral cortex, but it was still present in hippocampus.	W 7	28-31	FBJ osteosarcoma oncogene	Mus musculus	75-80
7548173-10	1995	Preincubation of RBL-2H3 cells with a CaM antagonist W-7 (20 microM) inhibited the antigen-stimulated PLD activity by 90%, but W-5, a chlorine-deficient analogue of W-7 that only weakly interact with CaM, caused little inhibitory effect.	W 7	53-56	RB transcriptional corepressor like 2	Rattus norvegicus	17-22
7733984-3	1995	We have shown here that calmodulin-dependent kinase II is involved in angiotensin II- and potassium-evoked aldosterone secretion as judged by the marked inhibitory effect of KN-62, a specific inhibitor of such a kinase, on aldosterone secretion and this inhibition was similar to that produced by calmodulin inhibitor, W-7.	W 7	319-322	calmodulin 1	Homo sapiens	24-34
7654391-6	1995	Calmodulin inhibitors, compound 48/80 and N-(6-aminohexyl)-1 naphthalenesulfonamide (W-7), inhibited the release of NCA in response to a variety of endotoxin concentrations.	W 7	85-88	calmodulin 1	Homo sapiens	0-10
7501704-4	1995	Calcium-induced platelet aggregation was inhibited by W-7 (a calmodulin antagonist), aspirin, indomethacin, TMB-8 (an inhibitor of intracellular Ca2+ release) and also nicardipine (a calcium antagonist).	W 7	54-57	calmodulin-2	Cavia porcellus	61-71
7543529-8	1995	DATK44-induced aggregation of TK1 cells is temperature sensitive and blocked by pretreatment of the cells with metabolic inhibitors, genestein, dibutyl cAMP or cytochalasin B, while colchicine, staurosporin, sphingosine, okadaic acid, and W7 are without effect.	W 7	239-241	thymidine kinase 1	Homo sapiens	30-33
7675313-2	1995	The calmodulin inhibitor, W-7, had similar effects: neither drug produced a complete block of photic responses.	W 7	26-29	calmodulin 1	Homo sapiens	4-14
7541946-6	1995	Calmodulin antagonists W-7, trifluoperazine, and R-24571 inhibited NOS, suggesting that the enzyme is regulated by calmodulin as in other cell types.	W 7	23-26	calmodulin 1	Homo sapiens	0-10
7775594-10	1995	Finally, MLCK inhibition (with either ML-7 or KT 5926) or Ca2+/calmodulin antagonism (with either trifluoperazine or W-7) attenuated thrombin-induced MLC phosphorylation and barrier dysfunction.	W 7	117-120	coagulation factor II, thrombin	Homo sapiens	133-141
7733984-3	1995	We have shown here that calmodulin-dependent kinase II is involved in angiotensin II- and potassium-evoked aldosterone secretion as judged by the marked inhibitory effect of KN-62, a specific inhibitor of such a kinase, on aldosterone secretion and this inhibition was similar to that produced by calmodulin inhibitor, W-7.	W 7	319-322	angiotensinogen	Homo sapiens	70-84
7541915-12	1995	The calmodulin antagonist W-7 interferes at multiple steps of intracellular signal-transduction pathways.	W 7	26-29	calmodulin 1	Rattus norvegicus	4-14
7655425-8	1995	Moreover, calmodulin was indicated as being possibly concerned with the down regulation of renal glucose-6-phosphatase activity by using W-7 (5 mumol/kg, i.p.	W 7	137-140	calmodulin 1	Rattus norvegicus	10-20
7655425-8	1995	Moreover, calmodulin was indicated as being possibly concerned with the down regulation of renal glucose-6-phosphatase activity by using W-7 (5 mumol/kg, i.p.	W 7	137-140	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	97-118
7756110-7	1995	W-7 and trifluoperazine dihydrochloride, antagonists of calmodulin, dose-dependently inhibited the PGD2-induced choline formation.	W 7	0-3	calmodulin 1	Homo sapiens	56-66
7874572-5	1995	W-7, a calmodulin inhibitor, decreased ODC enzyme activity in a dose-dependent, reversible fashion while trifluoperazine, another calmodulin inhibitor, failed to affect ODC enzyme activity in MC-26 cells.	W 7	0-3	calmodulin 2	Mus musculus	7-17
7874572-5	1995	W-7, a calmodulin inhibitor, decreased ODC enzyme activity in a dose-dependent, reversible fashion while trifluoperazine, another calmodulin inhibitor, failed to affect ODC enzyme activity in MC-26 cells.	W 7	0-3	ornithine decarboxylase, structural 1	Mus musculus	39-42
7823773-5	1995	A calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), at the concentration of 10(-6) M and a myosin light-chain kinase inhibitor, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), at concentrations above 10(-7) M also significantly blocked 10 mM nicotine-induced pepsinogen secretion.	W 7	77-80	calmodulin 1	Homo sapiens	2-12
8926637-4	1995	Calmodulin antagonist (W-7) was very effective in inhibiting the potentiating effects of A23187 on VIP and ISO-stimulated production of cAMP.	W 7	23-26	calmodulin 2	Gallus gallus	0-10
8926637-4	1995	Calmodulin antagonist (W-7) was very effective in inhibiting the potentiating effects of A23187 on VIP and ISO-stimulated production of cAMP.	W 7	23-26	vasoactive intestinal peptide	Gallus gallus	99-102
7564880-5	1995	However, indomethacin, diclofenac, phenylbutazone, mefenamic acid, naproxen, piroxicam, aspirin and W-7 inhibit, in a concentration-dependent way, the calmodulin-stimulated activity of phosphodiesterase.	W 7	100-103	calmodulin 1	Rattus norvegicus	151-161
7895032-5	1994	Pretreatment with W-7, a calmodulin antagonist, at concentrations of 10 microM or higher (up to 100 microM) produced a dose-dependent attenuation of ionomycin-induced increase in oxidative metabolism.	W 7	18-21	calmodulin 1	Homo sapiens	25-35
7961970-10	1994	Both staurosporine and calphostin C inhibited phosphorylation of the cotransporter at concentrations known to inhibit PKC, whereas the calmodulin antagonist W-7 had no significant effect.	W 7	157-160	calmodulin 1	Homo sapiens	135-145
7924416-6	1994	This effect could be reproduced with W-7, another calmodulin antagonist.	W 7	37-40	calmodulin 1	Homo sapiens	50-60
7961864-3	1994	Treatment of Madin-Darby canine kidney cells expressing the polymeric immunoglobulin receptor or a macrophage IgG Fc receptor with the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) inhibited their ability to mediate transcytosis of dimeric IgA or lysosomal degradation of immune complexes, respectively.	W 7	157-208	calmodulin-2	Canis lupus familiaris	135-145
7961864-3	1994	Treatment of Madin-Darby canine kidney cells expressing the polymeric immunoglobulin receptor or a macrophage IgG Fc receptor with the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) inhibited their ability to mediate transcytosis of dimeric IgA or lysosomal degradation of immune complexes, respectively.	W 7	210-213	calmodulin-2	Canis lupus familiaris	135-145
7866904-6	1994	It is indicated that calmodulin antagonist W-7 can enhance the anticancer effect of vinblastine.	W 7	43-46	calmodulin 1	Homo sapiens	21-31
7943429-13	1994	The effect on 3-O-methylglucose (3-MG) transport of 50 microM W-7 was additive to the effect of a maximal insulin stimulus (2,000 microU/ml) but not to the effect of maximal (60 min) hypoxic stimulus, suggesting that W-7 stimulates glucose transport via the same pathway as hypoxia, independent of the pathway activated by insulin.	W 7	62-65	insulin	Homo sapiens	106-113
7943429-13	1994	The effect on 3-O-methylglucose (3-MG) transport of 50 microM W-7 was additive to the effect of a maximal insulin stimulus (2,000 microU/ml) but not to the effect of maximal (60 min) hypoxic stimulus, suggesting that W-7 stimulates glucose transport via the same pathway as hypoxia, independent of the pathway activated by insulin.	W 7	62-65	insulin	Homo sapiens	323-330
7524360-7	1994	The effect of TG on net P(i) secretion was reduced by the Ca2+ channel blocker verapamil (VE, 100 microM) to 65% of control and by calmodulin antagonist W-7 (20 microM) to 35% of control but it was not blocked by the protein kinase inhibitor H-7 (100 microM).	W 7	153-156	calmodulin 1	Homo sapiens	131-141
7927239-6	1994	The epidermal growth factor-induced intracellular pH increase was inhibited by pretreatment of hepatocytes with genistein (100 mumol/L), thapsigargin (3 mumol/L) or calmodulin inhibitor W-7 (25 mumol/L), but not with protein kinase C inhibitor H-7 (50 mumol/L) or with cyclic AMP-dependent kinase inhibitor H-8 (60 mumol/L).	W 7	186-189	epidermal growth factor	Homo sapiens	4-27
7798426-5	1994	However, the expression of ICAM-1 was highly resistant to the inhibitory effects of W-7.	W 7	84-87	intercellular adhesion molecule 1	Homo sapiens	27-33
7913411-7	1994	Using calmodulin inhibitors (W7 and calmidazolium), we found that retinoic acid-stimulated, A23187-stimulated, and thapsigargin-stimulated but not FIN-gamma-stimulated ICAM-1 were inhibited.	W 7	29-31	calmodulin 1	Homo sapiens	6-16
7518388-7	1994	Ca(2+)-dependent PRG expression was abolished by the calmodulin inhibitor W-7.	W 7	74-77	proline rich protein BstNI subfamily 3	Homo sapiens	17-20
7943429-15	1994	In contrast, 50 microM W-7 had an inhibitory effect on stimulation of 3-MG transport by submaximally effective insulin levels, causing a fivefold increase in the concentration of insulin needed to produce a half-maximal stimulation of 3-MG transport, from approximately 70 to approximately 350 microU/ml (P < 0.05).	W 7	23-26	insulin	Homo sapiens	111-118
7943429-15	1994	In contrast, 50 microM W-7 had an inhibitory effect on stimulation of 3-MG transport by submaximally effective insulin levels, causing a fivefold increase in the concentration of insulin needed to produce a half-maximal stimulation of 3-MG transport, from approximately 70 to approximately 350 microU/ml (P < 0.05).	W 7	23-26	insulin	Homo sapiens	179-186
7943429-16	1994	Thus these data demonstrate that W-7 selectively inhibits insulin stimulation of glucose transport.	W 7	33-36	insulin	Homo sapiens	58-65
7948813-4	1994	Artificial wounds recovered in 36 h in controls; however, mucosal cell repair was inhibited by treatment with the actin inhibitor, cytochalasin B, and the calmodulin inhibitor, W-7.	W 7	177-180	calmodulin	Oryctolagus cuniculus	155-165
7982885-2	1994	Chelation of Ca2+ by EGTA or addition of calmodulin antagonists, W-7 or trifluoperazine, completely blocked this inactivation.	W 7	65-68	calmodulin 1	Homo sapiens	41-51
8207755-1	1994	A recent report has indicated that cadmium-induced testicular damage in CF-1 mice can be prevented by pretreatment with calmodulin inhibitors such as chlorpromazine (CPZ), trifluoperazine, or N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7).	W 7	245-248	calmodulin 2	Mus musculus	120-130
8179019-7	1994	In addition, even though A23187 was an effective stimulator of LIF production, the calmodulin antagonists W-7 and trifluoperazone dichoride (TFP) did not significantly alter the LIF-stimulatory effects of IL-1 and TGF-beta.	W 7	106-109	calmodulin 1	Homo sapiens	83-93
8143865-1	1994	Low concentrations of the calmodulin antagonist W-7 (1-10 microM) enhanced the respiratory burst (RB) of human polymorphonuclear leukocytes (PMN) stimulated by N-formyl-methionyl-leucyl-phenylalanine, whereas high drug concentrations (above 20 microM) depressed it.	W 7	48-51	calmodulin 1	Homo sapiens	26-36
8120367-3	1994	Phosphorylation of p25 was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), an inhibitor of calmodulin-dependent protein kinase, but not by tyrphostin nor ionomycin.	W 7	40-91	tubulin polymerization promoting protein	Homo sapiens	19-22
7517325-6	1994	4</protein-id> The calmodulin inhibitors calmidazolium (3-10 microM) and W-7 (100 microM) also abolished CPA-induced relaxation.	W 7	73-76	calmodulin 1	Rattus norvegicus	19-29
8120367-3	1994	Phosphorylation of p25 was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), an inhibitor of calmodulin-dependent protein kinase, but not by tyrphostin nor ionomycin.	W 7	93-96	tubulin polymerization promoting protein	Homo sapiens	19-22
8289674-9	1994	N-(6-aminohexyl)-5-chloro-1-Naphthalenesulfonamide ([W-7] 30 to 40 mumol/L) showed a more profound suppressive effect on ODC induced by PDGF and FGF than N-(6-aminohexyl)-naphthalenesulfonamide (W-5) did.	W 7	0-50	ornithine decarboxylase, structural 1	Mus musculus	121-124
8282374-11	1994	Addition of the calmodulin inhibitor W-7 completely reversed the inhibition of renin by high-calcium medium.	W 7	37-40	calmodulin 1	Rattus norvegicus	16-26
8279559-2	1993	Strontium substitution for calcium and the protein kinase C (PKC) inhibitor H-7 abolished the tone, whereas the calmodulin antagonist W-7 had no effect, suggesting that tone depends on intracellular calcium release and the PKC pathway.	W 7	134-137	calmodulin 1	Homo sapiens	112-122
7901336-4	1993	In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP).	W 7	248-251	calmodulin 1	Homo sapiens	123-133
8396507-6	1993	This inhibitory effect of Ca2+ in the presence of CaM was prevented by CaM inhibitors N-(6 aminohexyl)-5-chloro-1-naphthalenesulfonamide and calmidazolium but not by CaM kinase II inhibitor KN62.	W 7	86-136	calmodulin 1	Homo sapiens	50-53
8396507-6	1993	This inhibitory effect of Ca2+ in the presence of CaM was prevented by CaM inhibitors N-(6 aminohexyl)-5-chloro-1-naphthalenesulfonamide and calmidazolium but not by CaM kinase II inhibitor KN62.	W 7	86-136	calmodulin 1	Homo sapiens	71-74
8396507-6	1993	This inhibitory effect of Ca2+ in the presence of CaM was prevented by CaM inhibitors N-(6 aminohexyl)-5-chloro-1-naphthalenesulfonamide and calmidazolium but not by CaM kinase II inhibitor KN62.	W 7	86-136	calmodulin 1	Homo sapiens	71-74
8349322-7	1993	Pretreatment of both cell groups with a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, completely blocked arginine vasopressin-induced intracellular alkalinization and increased intracellular sodium concentration.	W 7	63-113	arginine vasopressin	Rattus norvegicus	143-154
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	W 7	19-22	calmodulin 1	Homo sapiens	26-36
7506289-5	1993	A calmodulin inhibitor (W-7) showed no effect on IL-1 beta-induced NOx production, whereas cycloheximide and the actinomycin D completely inhibited NOx production.	W 7	24-27	calmodulin 2	Mus musculus	2-12
7504810-11	1993	These results indicate that W-7 blocks the Na/Ca exchange current not by binding to calmodulin but possibly by directly affecting an internal site of the exchanger itself and that the inhibitory action of W-7 is different on the Na/Ca exchange current and the Na current.	W 7	28-31	calmodulin-3	Cavia porcellus	84-94
8499453-0	1993	Inhibition of mitochondrial translation by calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide.	W 7	65-115	calmodulin 2	Mus musculus	43-53
8242686-14	1993	However, treatment with N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (also termed W-7), a calmodulin antagonist, did not alter the total AcChoE activity, but significantly increased the DE/HSS ratio of AcChoE forms.	W 7	24-74	calmodulin 2	Gallus gallus	96-106
8242686-14	1993	However, treatment with N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (also termed W-7), a calmodulin antagonist, did not alter the total AcChoE activity, but significantly increased the DE/HSS ratio of AcChoE forms.	W 7	24-74	acetylcholinesterase (Cartwright blood group)	Gallus gallus	208-214
8358025-1	1993	Several amphiphilic cations such as mepacrine, desipramine, didodecyldimethylamine, chlorpromazine, oleylamine and W-7 activated the phospholipase D (PLD) activity of cultured LA-N-2 cells.	W 7	115-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	133-148
8358025-1	1993	Several amphiphilic cations such as mepacrine, desipramine, didodecyldimethylamine, chlorpromazine, oleylamine and W-7 activated the phospholipase D (PLD) activity of cultured LA-N-2 cells.	W 7	115-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	150-153
8476023-6	1993	Calmodulin antagonism with N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide reduced the Vmax and shifted the pH50 in the acidic direction, especially in the A-431 cells.	W 7	27-77	calmodulin 1	Homo sapiens	0-10
7504105-21	1993	Calmodulin inhibitors such as chlorpromazine, W-7 and trifluoperazine inhibited the IACh in a concentration-dependent manner.	W 7	46-49	calmodulin-3	Cavia porcellus	0-10
7686456-0	1993	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, reverses the inhibitory effect of insulin on lipolysis due to dibutyryl cyclic AMP.	W 7	0-50	calmodulin 1	Rattus norvegicus	54-64
8473433-2	1993	Experiments using three agents capable of inhibiting calmodulin activity, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W7), W7 linked to agarose beads (W7-agarose) and calmodulin antibody, showed that W7 and calmodulin antibody arrested division of embryos in a dose-dependent manner.	W 7	74-125	calmodulin 1	Homo sapiens	209-226
7901336-4	1993	In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP).	W 7	195-246	carbonic anhydrase 1	Homo sapiens	32-35
7901336-4	1993	In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP).	W 7	195-246	calmodulin 1	Homo sapiens	123-133
7901336-4	1993	In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP).	W 7	195-246	calmodulin 1	Homo sapiens	123-133
7901336-4	1993	In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP).	W 7	248-251	calmodulin 1	Homo sapiens	123-133
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	W 7	19-22	calmodulin 1	Homo sapiens	38-41
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	W 7	19-22	calmodulin 1	Homo sapiens	144-147
8422259-0	1993	The calmodulin antagonist W-7 depletes intracellular calcium stores in FRTL-5 thyroid cells.	W 7	26-29	calmodulin 1	Rattus norvegicus	4-14
8426095-8	1993	A calmodulin-dependent kinase inhibitor, W-7, was found to be effective, with 50% inhibition of Fn120-induced TNF secretion at 5 microM.	W 7	41-44	tumor necrosis factor	Homo sapiens	110-113
8422259-1	1993	Incubating Fura 2 loaded thyroid FRTL-5 cells with the calmodulin inhibitor W-7 decreased the ATP-evoked increase in intracellular free calcium.	W 7	76-79	calmodulin 1	Rattus norvegicus	55-65
8382363-8	1993	Calmodulin inhibitors (trifluoperazine or W-7) increased [Ca2+]i.	W 7	42-45	calmodulin	Oryctolagus cuniculus	0-10
1337998-6	1992	We have therefore further investigated the role of Ca2+ in the regulation of the MTS1 and NM23 genes using the calmodulin inhibitor W-7.	W 7	132-135	cyclin dependent kinase inhibitor 2A	Mus musculus	81-85
1338103-16	1992	The pHi response induced by the hyperosmotic stress was abolished by two calmodulin inhibitors, W-7 and chlorpromazine (50% inhibition, Ki at 28 and 20 microM, respectively), 20 microM cytochalasin B, but not by 10 microM colchicine.	W 7	96-99	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
1445301-3	1992	The stimulating effect of IL-1 beta on iR-ET production was respectively inhibited by protein kinase C (C kinase) inhibitor (H-7), Ca-calmodulin inhibitor (W-7), cyclic AMP-dependent protein kinase (A kinase) inhibitor (H-8) and tyrosine kinase inhibitor (genistain) in a dose-dependent fashion.	W 7	156-159	interleukin 1 beta	Homo sapiens	26-35
1380512-7	1992	However, TGF-beta 1 did induce the CEA responses in intact cells treated with the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7), the calmodulin-dependent phosphodiesterase inhibitor calmidazolium, the diacylglycerol kinase inhibitor R59 022, and the G-protein inhibitors cholera toxin and pertussis toxin.	W 7	170-173	transforming growth factor beta 1	Homo sapiens	9-19
1380512-7	1992	However, TGF-beta 1 did induce the CEA responses in intact cells treated with the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7), the calmodulin-dependent phosphodiesterase inhibitor calmidazolium, the diacylglycerol kinase inhibitor R59 022, and the G-protein inhibitors cholera toxin and pertussis toxin.	W 7	170-173	CEA cell adhesion molecule 3	Homo sapiens	35-38
1381016-4	1992	The calmodulin inhibitors trifluoperazine, W-7, calmidazolium, W-13, and CGS 9343B improved postischemic contractile function and/or reduced LDH release.	W 7	43-46	calmodulin 1	Rattus norvegicus	4-14
1484367-11	1992	Another means of increasing SR Ca2+ cycling was to partially remove the calmodulin-dependent control of SR Ca2+ release using the calmodulin inhibitor W-7.	W 7	151-154	calmodulin 2	Mus musculus	72-82
1484367-11	1992	Another means of increasing SR Ca2+ cycling was to partially remove the calmodulin-dependent control of SR Ca2+ release using the calmodulin inhibitor W-7.	W 7	151-154	calmodulin 2	Mus musculus	130-140
16669053-3	1992	A CaM antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), inhibited blue light-dependent proton pumping, whereas its less active structural analog, N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5), had little effect on the response.	W 7	18-68	calmodulin 1	Homo sapiens	2-5
1378960-3	1992	The inhibitory effect of the drug on taurine transport appears to be due to interference with calmodulin-dependent processes because calmodulin antagonists such as W-7, calmidazolium, and CGS 9343B mimic the effects of cyclosporin A.	W 7	164-167	calmodulin 1	Homo sapiens	133-143
1320129-6	1992	The calmodulin antagonist W-7 significantly decreased the isoproterenol-induced phosphorylation of phospholamban at [Ca]o 1.35 mM.	W 7	26-29	calmodulin 1	Rattus norvegicus	4-14
1374468-2	1992	The endothelium-dependent relaxations evoked by acetylcholine, ATP and the calcium ionophore A23187 (which are mediated by the constitutive nitric oxide synthase) were inhibited by calmodulin inhibitors [calmidazolium, W-7 and (N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide, hydrochloride, fendiline] and by an inhibitor of nitric oxide synthase, nitro L-arginine.	W 7	219-222	calmodulin 1	Rattus norvegicus	181-191
1575767-1	1992	Thrombin-stimulated secretion of endothelin-1 (ET-1) from porcine aortic endothelial cells was inhibited in the presence of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester (TMB-8), trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	210-260	coagulation factor II, thrombin	Homo sapiens	0-8
1575767-1	1992	Thrombin-stimulated secretion of endothelin-1 (ET-1) from porcine aortic endothelial cells was inhibited in the presence of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester (TMB-8), trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	210-260	endothelin 1	Homo sapiens	33-45
1575767-1	1992	Thrombin-stimulated secretion of endothelin-1 (ET-1) from porcine aortic endothelial cells was inhibited in the presence of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester (TMB-8), trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	210-260	endothelin 1	Homo sapiens	47-51
1313230-4	1992	However, addition of calmodulin or the presence of the calmodulin inhibitor W-7 (up to 100 microM) had no effect.	W 7	76-79	calmodulin	Anas platyrhynchos	55-65
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	W 7	63-114	calmodulin 2	Mus musculus	18-28
1917990-1	1991	A novel Ca(2+)-binding protein, tentatively designated calgizzarin, has been purified to apparent homogeneity from chicken gizzard smooth muscle by W-7 (N-(6-aminohexyl-5-chloro-1-naphthalenesulfonamide))-Sepharose affinity chromatography and ion-exchange chromatography.	W 7	148-151	S100 calcium binding protein A11	Gallus gallus	55-66
1354116-2	1992	In malignant hyperthermia susceptible muscle fibers, the calmodulin antagonist, W-7 (10 microM), evoked contractures and potentiated halothene (3%) induced contracture.	W 7	80-83	calmodulin 1	Homo sapiens	57-67
1613824-0	1992	Calmodulin antagonists chlorpromazine and W-7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures.	W 7	42-45	calmodulin 1	Homo sapiens	0-10
1613824-2	1992	In this report we showed that calmodulin antagonists chlorpromazine (CPZ) and W-7 (N-[6-aminohexyl]-5-chloro-1-naphtalenesulfonamide), when added to fibroblast cell cultures, gave rise to a time- and dose-dependent decrease of sphingomyelinase activity.	W 7	78-81	calmodulin 1	Homo sapiens	30-40
1657994-7	1991	Furthermore, W-7 or W-5, a calmodulin antagonist, reversed the inhibition by CCK8 of PC synthesis, suggesting that a Ca(2+)-calmodulin-dependent pathway may be involved in CCK-induced inhibition of PC synthesis in acini.	W 7	13-16	cholecystokinin	Rattus norvegicus	77-80
1657994-13	1991	In addition, W-7 reversed the inhibitory effect of CCK treatment on cytidylyltransferase activity in acini.	W 7	13-16	cholecystokinin	Rattus norvegicus	51-54
1682136-12	1991	When hypothalamic cells were incubated with CTF and W-7 [N-(6-aminohexyl)5-chloro-1-naphthalenesulfonamide], an inhibitor of calmodulin, the secretion of DOPA was significantly (P less than 0.001) less than that in cultures that were not incubated with W-7.	W 7	57-106	nuclear factor I/A	Rattus norvegicus	44-47
1283979-2	1992	Calmodulin inhibitor (W-7, 100 microM) and Ca2+/CaM kinase II inhibitor (KN-62, 10 microM) reduced amylase secretion stimulated by cholecystokinin (CCK) or carbachol.	W 7	22-25	calmodulin 1	Rattus norvegicus	0-10
1283979-2	1992	Calmodulin inhibitor (W-7, 100 microM) and Ca2+/CaM kinase II inhibitor (KN-62, 10 microM) reduced amylase secretion stimulated by cholecystokinin (CCK) or carbachol.	W 7	22-25	cholecystokinin	Rattus norvegicus	148-151
1917990-1	1991	A novel Ca(2+)-binding protein, tentatively designated calgizzarin, has been purified to apparent homogeneity from chicken gizzard smooth muscle by W-7 (N-(6-aminohexyl-5-chloro-1-naphthalenesulfonamide))-Sepharose affinity chromatography and ion-exchange chromatography.	W 7	153-202	S100 calcium binding protein A11	Gallus gallus	55-66
1656780-3	1991	Calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) and calmidazolium, both caused a concentration-dependent inhibition of Na(+)-H+ exchange activity.	W 7	24-75	calmodulin-1	Sus scrofa	0-10
1656780-3	1991	Calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) and calmidazolium, both caused a concentration-dependent inhibition of Na(+)-H+ exchange activity.	W 7	77-80	calmodulin-1	Sus scrofa	0-10
1656781-9	1991	The acidification-induced [Ca2+]i increase was inhibited by preincubation with verapamil or the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	W 7	118-168	calmodulin-1	Sus scrofa	96-106
1928327-3	1991	Prior exposure to the calmodulin antagonists calmidazolium (3 and 10 microM) and W-7 (10 microM) inhibited contractions to PMA in the presence and absence of extracellular Ca2+, while contractions to norepinephrine and KCl remained relatively unaffected.	W 7	81-84	calmodulin 1	Rattus norvegicus	22-32
24186430-2	1991	These currents, which were activated by 1-s voltage pulses of -100 mV (vacuolar interior negative) in the presence of 100 muM Ca(2+) (cytosolic side), could be blocked completely and reversibly by the calmodulin antagonist W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide] and its chlorine-deficient analogue W-5; half-maximum inhibition was found at approx.	W 7	223-226	calmodulin	Bos taurus	201-211
24186430-2	1991	These currents, which were activated by 1-s voltage pulses of -100 mV (vacuolar interior negative) in the presence of 100 muM Ca(2+) (cytosolic side), could be blocked completely and reversibly by the calmodulin antagonist W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide] and its chlorine-deficient analogue W-5; half-maximum inhibition was found at approx.	W 7	228-278	calmodulin	Bos taurus	201-211
1804554-3	1991	Both dithiothreitol (DTT) and N-(6-aminohexyl)-5-chloro-naphthalene sulfonamide (W-7) also inhibited the beta-glucuronidase release induced by CuPh.	W 7	81-84	glucuronidase beta	Homo sapiens	105-123
1887879-13	1991	The stimulatory effects of vasopressin on the malate-aspartate shuttle were also inhibited by W-7, trifluoperazine, and chlorpromazine.	W 7	94-97	arginine vasopressin	Rattus norvegicus	27-38
1663111-3	1991	Other calmodulin antagonists, such as trifluoperazine, thioridazine, and W-7, also inhibited the Ni(2+)-stimulated phosphatase activity.	W 7	73-76	calmodulin 1	Homo sapiens	6-16
2050666-6	1991	In addition, the calmodulin antagonist W-7 was found to prevent stimulation of endothelial cell Na-K-Cl cotransport by the three peptides.	W 7	39-42	calmodulin	Bos taurus	17-27
1649824-1	1991	The effects of a specific calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) on the synthesis of tissue inhibitor of metalloproteinases (TIMP) and precursor of matrix metalloproteinase 1/tissue collagenase (proMMP-1) and matrix metalloproteinase 3/stromelysin (proMMP-3), were examined using human uterine cervical fibroblasts in culture.	W 7	48-98	TIMP metallopeptidase inhibitor 1	Homo sapiens	165-169
1649824-1	1991	The effects of a specific calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) on the synthesis of tissue inhibitor of metalloproteinases (TIMP) and precursor of matrix metalloproteinase 1/tissue collagenase (proMMP-1) and matrix metalloproteinase 3/stromelysin (proMMP-3), were examined using human uterine cervical fibroblasts in culture.	W 7	48-98	matrix metallopeptidase 1	Homo sapiens	188-275
1714774-5	1991	Similarly, the calmodulin antagonist W-7 (50 microM) inhibited the IL-1-induced stimulation.	W 7	37-40	calmodulin 1	Homo sapiens	15-25
1649989-5	1991	Hypoxia-induced erythropoietin formation, however, was blocked by calmidazolium (1 microM) and W-7 (10 microM), two structurally different putative calmodulin antagonists.	W 7	95-98	erythropoietin	Rattus norvegicus	16-30
2018358-0	1991	Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma.	W 7	58-108	calmodulin 2	Mus musculus	35-45
2018358-1	1991	The antimetastatic effect of calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) was examined in an experimental model of lung metastasis induced by Lewis lung carcinomas (3LL) in C57BL/6crSlc mice.	W 7	52-102	calmodulin 2	Mus musculus	29-39
2018358-1	1991	The antimetastatic effect of calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) was examined in an experimental model of lung metastasis induced by Lewis lung carcinomas (3LL) in C57BL/6crSlc mice.	W 7	104-107	calmodulin 2	Mus musculus	29-39
1895755-4	1991	The TGF beta 1 effect was blocked by phorbol ester and partially blocked by the calmodulin antagonist W-7, but not by dexamethasone.	W 7	102-105	transforming growth factor beta 1	Homo sapiens	4-14
1649824-1	1991	The effects of a specific calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) on the synthesis of tissue inhibitor of metalloproteinases (TIMP) and precursor of matrix metalloproteinase 1/tissue collagenase (proMMP-1) and matrix metalloproteinase 3/stromelysin (proMMP-3), were examined using human uterine cervical fibroblasts in culture.	W 7	48-98	TIMP metallopeptidase inhibitor 1	Homo sapiens	125-163
2018129-5	1991	The calmodulin antagonist W-7 (10(-9) M) inhibited the maximal contraction induced by Ins(1,4,5)P3 but not contraction caused by PKC, whereas the PKC antagonist H-7 (10(-6) M) inhibited the maximal contraction induced by PKC but not contraction caused by Ins(1,4,5)P3.	W 7	26-29	calmodulin	Oryctolagus cuniculus	4-14
1852223-7	1991	Calmodulin antagonists (trifluoperazine, W-7 and calmidazolium; all of them at 10-100 mumol/l) inhibited contraction in sensitized and normal trachea.	W 7	41-44	calmodulin-3	Cavia porcellus	0-10
1908695-5	1991	t-PA production induced by p.peptone was inhibited in a dose-dependent manner by Verapamil, which inhibits Ca2+ uptake through the slow channels and also by W-7, an inhibitor of calmodulin.	W 7	157-160	plasminogen activator, tissue type	Homo sapiens	0-4
2148954-6	1990	N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7, 10(-7)M), a potent calmodulin inhibitor, or ryanodine (10(-8)M) had similar inhibitory action against the pressure-induced increase of ANP release.	W 7	0-51	calmodulin 1	Rattus norvegicus	77-87
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	W 7	62-65	calmodulin 2	Mus musculus	20-30
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	W 7	62-65	calmodulin 2	Mus musculus	102-112
2148954-6	1990	N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7, 10(-7)M), a potent calmodulin inhibitor, or ryanodine (10(-8)M) had similar inhibitory action against the pressure-induced increase of ANP release.	W 7	0-51	natriuretic peptide A	Rattus norvegicus	193-196
2384538-1	1990	The protective effects of protein kinase inhibitors and a calmodulin kinase inhibitor (W-7) against ischemic neuronal damage were examined in the CA1 subfield of the hippocampus.	W 7	87-90	carbonic anhydrase 1	Rattus norvegicus	146-149
2167684-6	1990	Although the CaM antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7) and TFP, decreased and increased, respectively, the fluorescence intensity caused by 2-p-toluidinylnaphthalene-6-sulfonic acid (TNS)-CaM binding, CD-349 only slightly decreased the fluorescence of TNS bound CaM.	W 7	96-99	calmodulin 1	Homo sapiens	13-16
2167684-6	1990	Although the CaM antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7) and TFP, decreased and increased, respectively, the fluorescence intensity caused by 2-p-toluidinylnaphthalene-6-sulfonic acid (TNS)-CaM binding, CD-349 only slightly decreased the fluorescence of TNS bound CaM.	W 7	96-99	calmodulin 1	Homo sapiens	234-237
2167684-6	1990	Although the CaM antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7) and TFP, decreased and increased, respectively, the fluorescence intensity caused by 2-p-toluidinylnaphthalene-6-sulfonic acid (TNS)-CaM binding, CD-349 only slightly decreased the fluorescence of TNS bound CaM.	W 7	96-99	calmodulin 1	Homo sapiens	234-237
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	W 7	237-240	alpha hemoglobin stabilizing protein	Mus musculus	17-21
2229642-0	1990	Reversible inhibition of keratinocyte thymidine incorporation by the calmodulin antagonist, W-7.	W 7	92-95	calmodulin-3	Sus scrofa	69-79
2391767-6	1990	The effect of W-7 on calcium- and cadmium-saturated CaM was reflected in changes in the signals of Ile-27, Phe-68, Phe-92, Ile-100 and Val-142, as well as Met-71, Met-72, Met-76, Phe-89 and Phe-141.	W 7	14-17	calmodulin	Bos taurus	52-55
2391767-8	1990	W-7 also inhibits CaM activation by calcium and cadmium.	W 7	0-3	calmodulin	Bos taurus	18-21
2115792-0	1990	Regulation of mouse preimplantation development: inhibitory effect of the calmodulin antagonist W-7 on the first cleavage.	W 7	96-99	calmodulin 2	Mus musculus	74-84
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	W 7	237-240	calmodulin 2	Mus musculus	71-81
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	W 7	242-292	alpha hemoglobin stabilizing protein	Mus musculus	17-21
2154207-4	1990	In addition, two dissimilar antagonists of calmodulin, namely trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W - 7), attenuated the ouabain"s effect on cAMP production in response to forskolin.	W 7	82-132	calmodulin 1	Rattus norvegicus	43-53
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	W 7	242-292	calmodulin 2	Mus musculus	71-81
2158426-3	1990	The steroidogenic responses were also inhibited by the three other inhibitors of calmodulin (chlorpromazine, calmidazolium, and W-7).	W 7	128-131	calmodulin 2	Mus musculus	81-91
1695428-1	1990	N-(6-aminohexyl)-1-naphthalenesulfonamide (W5), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) and Triflupromazine (TFPr) are substances with calmodulin antagonistic properties.	W 7	48-98	calmodulin 1	Homo sapiens	151-161
2107756-3	1990	The increased enzymatic activity was blocked by cycloheximide, putrescine, and the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-napthalinesulfonamide (W-7).	W 7	156-159	calmodulin 1	Homo sapiens	83-93
2107756-11	1990	Increased levels of active ODC protein and enzymatic activity are sensitive to W-7 and putrescine.	W 7	79-82	ornithine decarboxylase 1	Homo sapiens	27-30
2155616-5	1990	Addition of a lower amount of either phosphatidylserine or sodium oleate to the reaction mixture was efficacious in attenuating the inhibition of the CaM-PDE by W-7, chlorpromazine, trifluoperazine, compound 48/80, or R-24571 but, in contrast, had little or no effect on the inhibition by K-259-2 or KS-619-1.	W 7	161-164	calmodulin	Bos taurus	150-153
1692334-10	1990	Combination of chlordecone with W-7 (CaM antagonist) increased the inhibitory effect of W-7 on CaM activity.	W 7	32-35	calmodulin 1	Homo sapiens	37-40
1692334-10	1990	Combination of chlordecone with W-7 (CaM antagonist) increased the inhibitory effect of W-7 on CaM activity.	W 7	32-35	calmodulin 1	Homo sapiens	95-98
1692334-10	1990	Combination of chlordecone with W-7 (CaM antagonist) increased the inhibitory effect of W-7 on CaM activity.	W 7	88-91	calmodulin 1	Homo sapiens	37-40
1692334-10	1990	Combination of chlordecone with W-7 (CaM antagonist) increased the inhibitory effect of W-7 on CaM activity.	W 7	88-91	calmodulin 1	Homo sapiens	95-98
34343209-6	2021	ET-1 induced a slow contraction of non-activated HSCs, which was inhibited by the non-muscle myosin II inhibitor blebbistatin, the calmodulin inhibitor W-7, and the ETA receptor antagonist ambrisentan.	W 7	152-155	endothelin 1	Mus musculus	0-4
2502197-5	1989	The calmodulin inhibitors W-7 and W-5 caused flickering of the single-channel current.	W 7	26-29	calmodulin 1	Rattus norvegicus	4-14
2584705-6	1989	LPS induction of IL-1 beta mRNA in human monocytes can be blocked by either an inhibitor of protein kinase C (PKc) 1-(5-isoquinolinesulfonyl)-2-methylpiperazine or an inhibitor of calcium/calmodulin (CaM) kinase N-(6-aminohexyl) 5-chloro-1-naphthalenesulfonamide, suggesting that both PKc and CaM kinase are involved in transducing signals initiated by LPS.	W 7	212-262	interleukin 1 beta	Homo sapiens	17-26
2601266-5	1989	The initial effect (at 3 and 5 min) was only partially inhibited by these maneuvers but was completely inhibited by trifluoperazine or W-7, which indicated that it was dependent on calmodulin and, accordingly, on Ca probably released from the intracellular store.	W 7	135-138	calmodulin 1	Rattus norvegicus	181-191
2481655-5	1989	Both IP3-and Ca2+-induced histamine release from permeabilized mast cells was inhibited by pretreatment with calmodulin inhibitors (W-7 and calmidazolium), or with cytochalasin D or colchicine.	W 7	132-135	calmodulin 1	Rattus norvegicus	109-119
2689868-5	1989	We found that W-7, a potent calmodulin antagonist, severely attenuated the induction of CAB mRNA by light, whereas W-5, a weak calmodulin antagonist, had little effect.	W 7	14-17	calmodulin	Glycine max	28-38
2571246-1	1989	Ketotifen was less active than azelastine in both assays of calmodulin reactivity and both drugs were less active than the recognized calmodulin inhibitor, W-7.	W 7	156-159	calmodulin	Bos taurus	134-144
2687518-4	1989	Isolated glomeruli were placed within the superfusion chamber and perfused with Krebs-Ringer solution at a constant flow of 0.3 ml/minute at 37 degrees C. Renin release was increased by calmodulin inhibitor, W-7 in both SHR and WKY.	W 7	208-211	renin	Rattus norvegicus	155-160
2630101-6	1989	The Pb2(+)-enhanced O2 consumption of the Ca2(+)-depleted cells was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) based on its calmodulin antagonistic action.	W 7	81-132	calmodulin 1	Rattus norvegicus	152-162
2735931-0	1989	Binding of protein kinase C to N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide through its ATP binding site.	W 7	31-81	proline rich transmembrane protein 2	Homo sapiens	11-27
2735931-2	1989	The naphthalenesulfonamide W7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide] is representative of a number of cationic amphiphilic inhibitors of PKC which appear to inhibit PKC by interacting with the acidic phospholipid cofactor of the enzyme, according to kinetic studies.	W 7	31-81	proline rich transmembrane protein 2	Homo sapiens	151-154
2735931-2	1989	The naphthalenesulfonamide W7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide] is representative of a number of cationic amphiphilic inhibitors of PKC which appear to inhibit PKC by interacting with the acidic phospholipid cofactor of the enzyme, according to kinetic studies.	W 7	31-81	proline rich transmembrane protein 2	Homo sapiens	179-182
2630101-6	1989	The Pb2(+)-enhanced O2 consumption of the Ca2(+)-depleted cells was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) based on its calmodulin antagonistic action.	W 7	134-137	calmodulin 1	Rattus norvegicus	152-162
2538148-2	1989	This inductive effect of IL-1 on collagenase production was augmented by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a specific inhibitor of calmodulin, in a dose-dependent manner.	W 7	73-123	calmodulin 1	Homo sapiens	155-165
2540282-0	1989	Calmodulin antagonist W-7 inhibits lysosomal sphingomyelinase activity in C6 glioma cells.	W 7	22-25	calmodulin 1	Homo sapiens	0-10
2540282-1	1989	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is known to be a potent calmodulin antagonist and inhibitor of calmodulin-dependent protein kinases.	W 7	0-50	calmodulin 1	Homo sapiens	81-91
2540282-1	1989	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is known to be a potent calmodulin antagonist and inhibitor of calmodulin-dependent protein kinases.	W 7	0-50	calmodulin 1	Homo sapiens	120-130
2540282-1	1989	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is known to be a potent calmodulin antagonist and inhibitor of calmodulin-dependent protein kinases.	W 7	52-55	calmodulin 1	Homo sapiens	81-91
2540282-1	1989	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is known to be a potent calmodulin antagonist and inhibitor of calmodulin-dependent protein kinases.	W 7	52-55	calmodulin 1	Homo sapiens	120-130
2538148-2	1989	This inductive effect of IL-1 on collagenase production was augmented by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a specific inhibitor of calmodulin, in a dose-dependent manner.	W 7	125-128	calmodulin 1	Homo sapiens	155-165
2537109-3	1989	The elevated ALP activity was prevented by prior treatment with flunarizine, a calcium channel blocker, and by W-7, a calmodulin antagonist.	W 7	111-114	calmodulin 1	Rattus norvegicus	118-128
2567567-4	1989	Similar to astemizole and oxatomide the calmodulin antagonists trifluoperazine and W-7 inhibited the eicosanoid release.	W 7	83-86	calmodulin 1	Homo sapiens	40-50
2567567-8	1989	The results demonstrate that the therapeutic antihistamines astemizole and oxatomide as well as the classical calmodulin antagonists trifluoperazine and W-7 are able to inhibit eicosanoid formation.	W 7	153-156	calmodulin 1	Homo sapiens	110-120
2473727-6	1989	Calmodulin inhibitors (W-7, trifluoperazine) blocked the IgE-mediated 45Ca2+ influx, (14C)-arachidonic acid and histamine release in the same dose-dependent manner, but were counteracted by 45% D2O.	W 7	23-26	calmodulin 1	Rattus norvegicus	0-10
2537092-8	1989	Further, it is suggested that the marked reduction in stimulation-evoked norepinephrine overflow and vasoconstrictor responses by W-7 showed the greater calmodulin-dependent regulation in the vascular adrenergic activity of DOCA-salt hypertension.	W 7	130-133	calmodulin 1	Rattus norvegicus	153-163
2536303-6	1989	Two other calmodulin antagonists [calmidazolium and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide] modified the gating behavior of the channel in the absence of exogenous calmodulin in a concentration- and Ca2+-dependent manner.	W 7	52-103	calmodulin 1	Homo sapiens	10-20
2493197-8	1989	Inhibition of calmodulin-mediated processes with N-(6-aminohexyl)-5-chloro-1-naphthalelesulfonamide (W-7), a calmodulin antagonist, inhibited the serum-stimulated induction of ODC in a dose-dependent manner, with an IC50 of approximately 10 microM.	W 7	101-104	calmodulin 1	Homo sapiens	14-24
2493197-8	1989	Inhibition of calmodulin-mediated processes with N-(6-aminohexyl)-5-chloro-1-naphthalelesulfonamide (W-7), a calmodulin antagonist, inhibited the serum-stimulated induction of ODC in a dose-dependent manner, with an IC50 of approximately 10 microM.	W 7	101-104	calmodulin 1	Homo sapiens	109-119
2493197-8	1989	Inhibition of calmodulin-mediated processes with N-(6-aminohexyl)-5-chloro-1-naphthalelesulfonamide (W-7), a calmodulin antagonist, inhibited the serum-stimulated induction of ODC in a dose-dependent manner, with an IC50 of approximately 10 microM.	W 7	101-104	ornithine decarboxylase 1	Homo sapiens	176-179
20504460-1	1989	Sodium- and energy-dependent accumulation of [(3)H]l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 ?M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners.	W 7	248-298	calmodulin 1	Rattus norvegicus	170-180
3145933-7	1988	W-7, a calmodulin inhibitor, significantly decreased the hypoxic histamine-mediated contraction, but 12-O-tetradecanoylphorbol-13-acetate (TPA), a C-kinase promotor, had no effect.	W 7	0-3	calmodulin 1	Homo sapiens	7-17
2856063-9	1988	The decrease in renin release was attenuated by calcium-interacting agents, such as nifedipine, TMB-8 and W-7, but these agents were without effect on the stimulation of the release by exposure to calcium.	W 7	106-109	renin	Rattus norvegicus	16-21
3241255-4	1988	Protein kinase C inhibitor H-7 and the calmodulin antagonist W-7 inhibited the stimulation-evoked noradrenaline release and pressor responses, respectively, in a dose-dependent manner.	W 7	61-64	calmodulin 1	Rattus norvegicus	39-49
24220739-6	1988	The Ca(2+)-dependent protein kinase is inhibited by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide and trifluoperazine with IC50 values of approx.	W 7	79-130	calmodulin	Malus domestica	56-66
3183602-1	1988	Involvement of calmodulin-dependent processes in preimplantation development of mouse embryos was studied with the use of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a specific antagonist of calmodulin.	W 7	174-177	calmodulin 2	Mus musculus	15-25
3210442-0	1988	1H-NMR studies of calmodulin: the modifying effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) on the calcium-induced conformational changes of calmodulin.	W 7	54-57	calmodulin 1	Homo sapiens	18-28
3210442-0	1988	1H-NMR studies of calmodulin: the modifying effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) on the calcium-induced conformational changes of calmodulin.	W 7	54-57	calmodulin 1	Homo sapiens	160-170
3210442-0	1988	1H-NMR studies of calmodulin: the modifying effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) on the calcium-induced conformational changes of calmodulin.	W 7	59-109	calmodulin 1	Homo sapiens	18-28
3210442-0	1988	1H-NMR studies of calmodulin: the modifying effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) on the calcium-induced conformational changes of calmodulin.	W 7	59-109	calmodulin 1	Homo sapiens	160-170
3210442-1	1988	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the calcium-bound conformation of calmodulin was studied by 1H-NMR at 400 MHz.	W 7	14-17	calmodulin 1	Homo sapiens	74-84
3210442-1	1988	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the calcium-bound conformation of calmodulin was studied by 1H-NMR at 400 MHz.	W 7	14-17	calmodulin 1	Homo sapiens	134-144
3210442-1	1988	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the calcium-bound conformation of calmodulin was studied by 1H-NMR at 400 MHz.	W 7	19-69	calmodulin 1	Homo sapiens	74-84
3210442-1	1988	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the calcium-bound conformation of calmodulin was studied by 1H-NMR at 400 MHz.	W 7	19-69	calmodulin 1	Homo sapiens	134-144
3210442-5	1988	The effect of W-7 on the structure of calmodulin was similar to that of other drugs, trifluoperazine, D600 and oxmetidine.	W 7	14-17	calmodulin 1	Homo sapiens	38-48
2971359-6	1988	The repair of the DNA lesions is prevented by treating the cells with W-7, an inhibitor of calmodulin.	W 7	70-73	calmodulin 1	Homo sapiens	91-101
3048249-5	1988	Furthermore, a number of drugs known to abolish the activation properties of calmodulin, such as trifluoperazine (TFP) or W-7, strongly inhibit insulin-receptor capping and myosin light-chain phosphorylation.	W 7	122-125	calmodulin 1	Homo sapiens	77-87
3390216-8	1988	Moreover, this compound suppresses platelet secretion and relaxes vascular strips, at concentrations similar to those seen with the CaM interacting action and characteristic of CaM antagonists such as W-7.	W 7	201-204	calmodulin 1	Homo sapiens	132-135
3390216-8	1988	Moreover, this compound suppresses platelet secretion and relaxes vascular strips, at concentrations similar to those seen with the CaM interacting action and characteristic of CaM antagonists such as W-7.	W 7	201-204	calmodulin 1	Homo sapiens	177-180
2453268-3	1988	When cells containing DNA lesions are treated with calmodulin inhibitors (W-7, phenothiazine, promethazine), the amount of lesions is increased, in all probability due to reduced DNA repair.	W 7	74-77	calmodulin 1	Homo sapiens	51-61
3048249-5	1988	Furthermore, a number of drugs known to abolish the activation properties of calmodulin, such as trifluoperazine (TFP) or W-7, strongly inhibit insulin-receptor capping and myosin light-chain phosphorylation.	W 7	122-125	insulin	Homo sapiens	144-151
3048249-5	1988	Furthermore, a number of drugs known to abolish the activation properties of calmodulin, such as trifluoperazine (TFP) or W-7, strongly inhibit insulin-receptor capping and myosin light-chain phosphorylation.	W 7	122-125	myosin heavy chain 14	Homo sapiens	173-179
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	W 7	62-65	calmodulin 2	Mus musculus	4-14
2906279-4	1988	The calmodulin antagonist, W-7, reduced not only vasoconstrictor responses but also norepinephrine overflow during nerve stimulation.	W 7	27-30	calmodulin 1	Rattus norvegicus	4-14
2905967-6	1988	Preincubation with H-8 reduced both W-5- and W-7-inhibited A23187-stimulated synapsin I phosphorylation by the same amount but did not affect their inhibitory effect nor the ionophore-stimulated norepinephrine release, thereby suggesting that W-5 may serve as an appropriate control for non-calmodulin-mediated effect of both calmodulin antagonists.	W 7	45-48	synapsin I	Rattus norvegicus	77-87
2905967-6	1988	Preincubation with H-8 reduced both W-5- and W-7-inhibited A23187-stimulated synapsin I phosphorylation by the same amount but did not affect their inhibitory effect nor the ionophore-stimulated norepinephrine release, thereby suggesting that W-5 may serve as an appropriate control for non-calmodulin-mediated effect of both calmodulin antagonists.	W 7	45-48	calmodulin 1	Rattus norvegicus	291-301
2905967-6	1988	Preincubation with H-8 reduced both W-5- and W-7-inhibited A23187-stimulated synapsin I phosphorylation by the same amount but did not affect their inhibitory effect nor the ionophore-stimulated norepinephrine release, thereby suggesting that W-5 may serve as an appropriate control for non-calmodulin-mediated effect of both calmodulin antagonists.	W 7	45-48	calmodulin 1	Rattus norvegicus	326-336
2468847-2	1988	The classical calmodulin antagonists calmidazolium, trifluorperazine, and W-7 were active at similar concentrations in the three experimental systems.	W 7	74-77	calmodulin 1	Homo sapiens	14-24
2460654-4	1988	W-7, a calmodulin antagonist, inhibited the amylase secretion induced by GRP.	W 7	0-3	gastrin releasing peptide	Rattus norvegicus	73-76
3677086-1	1987	The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.	W 7	129-180	calmodulin 2	Mus musculus	105-115
3677086-1	1987	The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.	W 7	182-185	calmodulin 2	Mus musculus	105-115
2537092-5	1989	The calmodulin antagonist (W-7) inhibited the stimulation-evoked norepinephrine overflow and pressor responses in a dose-dependent manner.	W 7	27-30	calmodulin 1	Rattus norvegicus	4-14
3395166-7	1988	In the canine femoral artery tensed up with high K+, all of these 3 CaM antagonists and 3 Ca++ channel blockers produced concentration-dependent vasorelaxation and relative potencies determined on the basis of concentrations producing IC30 were in the descending order: nicardipine greater than diltiazem greater than verapamil greater than calmidazolium greater than or equal to trifluoperazine greater than W-7.	W 7	409-412	calmodulin-3	Cavia porcellus	68-71
2452220-7	1988	Also, the calmodulin antagonist drug W7 (N-6-(aminohexyl)-5-chloro-1-naphthalene sulfonamide) inhibited the carbamylcholine-induced release of intracellular Ca2+ in acinar carcinoma cells.	W 7	41-92	calmodulin 1	Rattus norvegicus	10-20
2452922-0	1988	Structural variants of verapamil and W-7 with combined Ca2+ entry blockade/myosin phosphorylation inhibitory mechanisms.	W 7	37-40	myosin heavy chain 14	Homo sapiens	75-81
2449521-11	1988	The calmodulin blockers trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide increased the amplitude and duration of the current response.	W 7	44-94	calmodulin 1	Homo sapiens	4-14
2835563-4	1988	The ANP release stimulated by phenylephrine was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), a protein kinase C inhibitor.	W 7	61-111	calmodulin 1	Rattus norvegicus	121-131
2835563-4	1988	The ANP release stimulated by phenylephrine was inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), a protein kinase C inhibitor.	W 7	113-116	calmodulin 1	Rattus norvegicus	121-131
3116092-9	1987	A calmodulin antagonist W-7 effectively inhibited A23187-induced IL-1 production by C3H/He macrophages.	W 7	24-27	interleukin 1 complex	Mus musculus	65-69
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	W 7	62-65	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	W 7	62-65	calmodulin 2	Mus musculus	196-206
2821911-2	1987	The enzyme activity, as assessed by the production of inositol 1,3,4,5-tetrakisphosphate was reversibly activated by free Ca2+ concentrations ranging from 10(-7) to 10(-6)M. The calmodulin antagonists, W-7 and chlorpromazine, inhibited the Ca2+-activated enzyme activity in a dose-dependent fashion, thereby indicating that calmodulin may be involved in the activation by Ca2+.	W 7	202-205	calmodulin-3	Cavia porcellus	178-188
3631272-3	1987	O2 uptake was inhibited up to 80% in a dose-dependent fashion by the calmodulin inhibitor, W-7 (I0.5 = 50-60 microM).	W 7	91-94	calmodulin 1	Rattus norvegicus	69-79
2957366-3	1987	The identity of the phosphorylated protein as being calmodulin in intact cells was demonstrated by two-dimensional electrophoresis, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W7)-affinity chromatography, and positive staining with the Ca2+ binding protein stain Stains All.	W 7	132-183	calmodulin 1	Homo sapiens	52-62
2891352-5	1987	The stimulation by Ca2+ of the enzyme in cilia and ciliary membranes was blocked by the calmodulin antagonists calmidazolium (half-inhibition at 5 microM), trifluoperazine (70 microM) and W-7 (50-100 microM).	W 7	188-191	calmodulin 1	Homo sapiens	88-98
3570556-0	1987	W-7, a calmodulin inhibitor, potentiates dacarbazine cytotoxicity in human neoplastic cells.	W 7	0-3	calmodulin 1	Homo sapiens	7-17
3039914-9	1987	A variety of structurally diverse calmodulin antagonists examined were also found to effectively protect P-450Ch7 alpha from deactivation; these include calmidazolium and tamoxifen (IC50 = 25 to 50 microM), chlorpromazine, thioridazine, amitriptyline, imipramine, and the naphthalene sulfonamide compound W-7 (IC50 = 50 to 300 microM).	W 7	305-308	calmodulin 1	Rattus norvegicus	34-44
3040779-7	1987	In contrast, incubation of cells in nominally calcium-free medium or with the calmodulin antagonists W-7 or trifluoperazine (TFP) decreased only the ability of EGF to cause changes in pHi.	W 7	101-104	glucose-6-phosphate isomerase	Cricetulus griseus	184-187
3584987-6	1987	Calmodulin binding was inhibitable by trifluoperazine (TFP), W-7, and chloropramazine, all of which are calmodulin antagonists.	W 7	61-64	calmodulin 1	Homo sapiens	0-10
3584987-6	1987	Calmodulin binding was inhibitable by trifluoperazine (TFP), W-7, and chloropramazine, all of which are calmodulin antagonists.	W 7	61-64	calmodulin 1	Homo sapiens	104-114
3037298-7	1987	Use of hydrophobic fluorescence probes showed that Ro 22-4839 binds to the hydrophobic region of calmodulin like other calmodulin antagonists, trifluoperazine and W-7.	W 7	163-166	calmodulin 1	Rattus norvegicus	97-107
3036157-3	1987	Contrary to W-7, nicergoline, nicardipine and quercetin, which decreased the fluorescence of the two probes bound to calmodulin, bepridil only decreased 9AC fluorescence but increased the fluorescence intensity at the wavelength of the emission maximum of TNS.	W 7	12-15	calmodulin 1	Homo sapiens	117-127
3036157-4	1987	In spite of this difference, bepridil as well as W-7 and nicergoline competitively inhibited calmodulin activation of phosphodiesterase.	W 7	49-52	calmodulin 1	Homo sapiens	93-103
3570556-2	1987	Repair of these lesions does not occur when cells are post-treated with the calmodulin inhibitor W-7.	W 7	97-100	calmodulin 1	Homo sapiens	76-86
3570556-4	1987	The augmentation effect of W-7 is prevented by simultaneous incubation of cells with high levels of calmodulin and does not occur in cells pre-treated with aphidicolin (to stop DNA synthesis).	W 7	27-30	calmodulin 1	Homo sapiens	100-110
3570556-5	1987	Furthermore, W-5, an analogue of W-7 with a less inhibitory effect on calmodulin, does not interfere with DNA repair.	W 7	33-36	calmodulin 1	Homo sapiens	70-80
3495186-5	1987	Experiments were performed in which calmodulin antagonists, W-7 or trifluoperazine (TFP), were used to prevent Ca2+-dependent contractions or to relax previously contracted muscle strips.	W 7	60-63	calmodulin-3	Sus scrofa	36-46
3034277-3	1987	Both the protein kinase C inhibitor 1-(5-isoquinolinylsulfonyl) 2-methylpiperidine (H-7) and calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) reduced the superoxide generation induced by these stimuli.	W 7	115-165	calmodulin 1	Homo sapiens	93-103
3034277-3	1987	Both the protein kinase C inhibitor 1-(5-isoquinolinylsulfonyl) 2-methylpiperidine (H-7) and calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) reduced the superoxide generation induced by these stimuli.	W 7	167-170	calmodulin 1	Homo sapiens	93-103
3550349-0	1987	Renin release in anesthetized rats is enhanced by the calmodulin antagonist W-7.	W 7	76-79	renin	Rattus norvegicus	0-5
3579939-4	1987	When the cells were preincubated with the potent calmodulin antagonist, w-7 or w-13, the stimulatory effect of calcitonin on phosphate transport was significantly inhibited.	W 7	72-75	calmodulin-3	Sus scrofa	49-59
3550349-0	1987	Renin release in anesthetized rats is enhanced by the calmodulin antagonist W-7.	W 7	76-79	calmodulin 1	Rattus norvegicus	54-64
3550349-1	1987	In foregoing work, we found that the release of renin from rat kidney cortical slices was stimulated by the calmodulin antagonist W-7.	W 7	130-133	renin	Rattus norvegicus	48-53
3550349-1	1987	In foregoing work, we found that the release of renin from rat kidney cortical slices was stimulated by the calmodulin antagonist W-7.	W 7	130-133	calmodulin 1	Rattus norvegicus	108-118
3550349-5	1987	Infusion of W-7 at 100 micrograms/kg/min resulted in a marked stimulation of renin release, but there was no significant alteration in the release when the same dose of W-5 was infused.	W 7	12-15	renin	Rattus norvegicus	77-82
3108130-9	1987	In addition, CT-induced rise in enzyme activity was markedly reduced by the presence of W-7 (5 and 50 microM), a calmodulin inhibitor, in the enzyme assay system.	W 7	88-91	calcitonin-related polypeptide alpha	Rattus norvegicus	13-15
16665348-10	1987	Autophosphorylation of the calmodulin-free kinase was inhibited by the calmodulin-binding compound N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), showing that the inhibition of activity by W-7 is independent of calmodulin.	W 7	99-150	calmodulin	Glycine max	27-37
3037232-1	1987	Preincubation of hepatoma cells and human skin fibroblasts in the presence of the calmodulin antagonists trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide resulted in a dose-dependent suppression of [14C]mevalonolactone incorporation into cholesterol.	W 7	125-176	calmodulin 1	Homo sapiens	82-92
2823798-1	1987	The calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), or trifluoperazine inhibited not only Fc gamma-receptor mediated cytosolic free Ca2+ increase and O2- generation in macrophages, but also an arachidonate-induced activation of NADPH-oxidase in a cell-free system.	W 7	79-82	calmodulin 1	Homo sapiens	4-14
2823798-1	1987	The calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), or trifluoperazine inhibited not only Fc gamma-receptor mediated cytosolic free Ca2+ increase and O2- generation in macrophages, but also an arachidonate-induced activation of NADPH-oxidase in a cell-free system.	W 7	79-82	immunoglobulin kappa variable 1D-39	Homo sapiens	123-185
16665348-10	1987	Autophosphorylation of the calmodulin-free kinase was inhibited by the calmodulin-binding compound N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), showing that the inhibition of activity by W-7 is independent of calmodulin.	W 7	99-150	calmodulin	Glycine max	71-81
16665348-10	1987	Autophosphorylation of the calmodulin-free kinase was inhibited by the calmodulin-binding compound N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), showing that the inhibition of activity by W-7 is independent of calmodulin.	W 7	99-150	calmodulin	Glycine max	71-81
16665348-10	1987	Autophosphorylation of the calmodulin-free kinase was inhibited by the calmodulin-binding compound N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), showing that the inhibition of activity by W-7 is independent of calmodulin.	W 7	152-155	calmodulin	Glycine max	27-37
16665348-10	1987	Autophosphorylation of the calmodulin-free kinase was inhibited by the calmodulin-binding compound N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), showing that the inhibition of activity by W-7 is independent of calmodulin.	W 7	152-155	calmodulin	Glycine max	71-81
16665348-10	1987	Autophosphorylation of the calmodulin-free kinase was inhibited by the calmodulin-binding compound N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7), showing that the inhibition of activity by W-7 is independent of calmodulin.	W 7	152-155	calmodulin	Glycine max	71-81
2433345-9	1987	Moreover, the calmodulin antagonist W-7 also effectively inhibited the synergistic increase in cAMP.	W 7	36-39	calmodulin-3	Cavia porcellus	14-24
2824893-9	1987	A calmodulin antagonist, W-7 (100 microM) strongly suppressed both the K-contracture and the contraction induced by the test solution, whereas trifluoperazine (10-200 microM) preferentially depressed the K-contracture.	W 7	25-28	calmodulin 1	Rattus norvegicus	2-12
2439690-2	1987	These repeated hyperpolarizations were inhibited by putative calmodulin antagonists, trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and promethazine (PMZ), and the concentrations required for half-maximal inhibition were 25, 30 and 300 microM, respectively.	W 7	160-163	calmodulin 2	Mus musculus	61-71
3028406-4	1987	In contrast, the specific calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and the dual calmodulin antagonist/protein kinase C inhibitor trifluoperazine (TFP) were potent inhibitors of the response throughout the 30 minute incubation.	W 7	48-98	calmodulin 1	Homo sapiens	26-36
3028406-4	1987	In contrast, the specific calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and the dual calmodulin antagonist/protein kinase C inhibitor trifluoperazine (TFP) were potent inhibitors of the response throughout the 30 minute incubation.	W 7	100-103	calmodulin 1	Homo sapiens	26-36
2446688-9	1987	In contrast, W-7, an antagonist of the calcium-binding protein calmodulin, potentiated the effect of nisoldipine and, at higher concentrations, inhibited induction of DNA synthesis in itself.	W 7	13-16	calmodulin 1	Rattus norvegicus	63-73
2834593-6	1987	W-7 as calmodulin antagonist indirectly inhibited the enzyme activity and nifedipine as calmodulin-dependent phosphodiesterase antagonist directly inhibited the enzyme activity.	W 7	0-3	calmodulin	Bos taurus	7-17
3028385-7	1986	The ability of the virus to activate the enzyme was blocked in the presence of the known calmodulin inhibitors trifluoperazine and W-7.	W 7	131-134	calmodulin 1	Homo sapiens	89-99
11539029-10	1987	Calmodulin antagonist W-7 was effective in inhibiting calcium-promoted phosphorylation.	W 7	22-25	calmodulin1	Zea mays	0-10
3100062-5	1986	In addition, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin inhibitor, suppressed both IL-2 production and IL-2R expression.	W 7	13-63	calmodulin 1	Homo sapiens	73-83
2948504-3	1986	Conversely, the calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphtalene sulfonamide (W-7), induced Ca2+ release from the ER.	W 7	91-94	calmodulin 1	Homo sapiens	16-26
3100062-5	1986	In addition, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin inhibitor, suppressed both IL-2 production and IL-2R expression.	W 7	65-68	interleukin 2 receptor subunit beta	Homo sapiens	131-136
3100062-7	1986	Thus, the mechanism of action of Cy A appears to differ from that of the protein kinase inhibitor, H-7, and the calmodulin inhibitor, W-7.	W 7	134-137	calmodulin 1	Homo sapiens	112-122
2429133-12	1986	But the release was also inhibited by the calmodulin antagonists, W-7 and mepacrine, suggesting that the influx of calcium in the permeabilized cells acts primarily through calmodulin-mediated enzyme activation.	W 7	66-69	calmodulin 1	Homo sapiens	173-183
3803705-3	1986	The calmodulin antagonists, trifluoperazine, pimozide and W7 also prevented estrogen induction of prolactin production.	W 7	58-60	calmodulin 1	Rattus norvegicus	4-14
3097893-4	1986	CPZ and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) can also block calcium-dependent activation processes by inhibition of calmodulin and protein kinase C. All four compounds were found to suppress human and murine lymphoproliferation to both alloantigen or mitogen in a dose-dependent and saturable manner.	W 7	8-59	calmodulin 1	Homo sapiens	137-147
3097893-4	1986	CPZ and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7) can also block calcium-dependent activation processes by inhibition of calmodulin and protein kinase C. All four compounds were found to suppress human and murine lymphoproliferation to both alloantigen or mitogen in a dose-dependent and saturable manner.	W 7	61-64	calmodulin 1	Homo sapiens	137-147
3097893-5	1986	Exogenous interleukin-2 (IL-2) restored mitogenic responsiveness to cultures suppressed using W-7 and CsA, but not to lymphocytes suppressed with either CPZ or PB.	W 7	94-97	interleukin 2	Homo sapiens	10-23
3097893-5	1986	Exogenous interleukin-2 (IL-2) restored mitogenic responsiveness to cultures suppressed using W-7 and CsA, but not to lymphocytes suppressed with either CPZ or PB.	W 7	94-97	interleukin 2	Homo sapiens	25-29
3741880-0	1986	H-NMR studies of calmodulin: the effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) and Ca2+ on conformational changes of calmodulin.	W 7	43-46	calmodulin 1	Homo sapiens	17-27
3100062-5	1986	In addition, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin inhibitor, suppressed both IL-2 production and IL-2R expression.	W 7	13-63	interleukin 2	Homo sapiens	111-115
3100062-5	1986	In addition, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin inhibitor, suppressed both IL-2 production and IL-2R expression.	W 7	13-63	interleukin 2 receptor subunit beta	Homo sapiens	131-136
3100062-5	1986	In addition, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin inhibitor, suppressed both IL-2 production and IL-2R expression.	W 7	65-68	calmodulin 1	Homo sapiens	73-83
3100062-5	1986	In addition, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin inhibitor, suppressed both IL-2 production and IL-2R expression.	W 7	65-68	interleukin 2	Homo sapiens	111-115
3087600-4	1986	Another calmodulin inhibitor, N-(6-aminohexyl)-chloro-1-naphthalenesulfonamide (W-7), also inhibited AC in a calcium-independent manner with a IC50 of approximately 200 microM.	W 7	80-83	calmodulin 1	Homo sapiens	8-18
3741880-0	1986	H-NMR studies of calmodulin: the effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) and Ca2+ on conformational changes of calmodulin.	W 7	43-46	calmodulin 1	Homo sapiens	138-148
3741880-0	1986	H-NMR studies of calmodulin: the effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) and Ca2+ on conformational changes of calmodulin.	W 7	48-98	calmodulin 1	Homo sapiens	17-27
3741880-0	1986	H-NMR studies of calmodulin: the effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) and Ca2+ on conformational changes of calmodulin.	W 7	48-98	calmodulin 1	Homo sapiens	138-148
3741880-1	1986	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the structure of calmodulin was studied with 400 MHz H-NMR.	W 7	14-17	calmodulin 1	Homo sapiens	74-84
3741880-1	1986	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the structure of calmodulin was studied with 400 MHz H-NMR.	W 7	14-17	calmodulin 1	Homo sapiens	117-127
3741880-1	1986	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the structure of calmodulin was studied with 400 MHz H-NMR.	W 7	19-69	calmodulin 1	Homo sapiens	74-84
3741880-1	1986	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the structure of calmodulin was studied with 400 MHz H-NMR.	W 7	19-69	calmodulin 1	Homo sapiens	117-127
3741880-5	1986	The modifying effect of W-7 on the methyl-group resonances of calmodulin fully bound with Ca2+ was similar to that of trifluoperazine.	W 7	24-27	calmodulin 1	Homo sapiens	62-72
16664960-1	1986	Calmodulin antagonists, trifluoperazine, chlorpromazine, calmidazolium, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), strongly inhibited the electrofusion of barley (Hordeum vulgare L. cv Moor) protoplasts with a marked increase of broken fusion products, after 60 minutes of incubation.	W 7	72-122	calmodulin	Hordeum vulgare	0-10
3753505-2	1986	Calmodulin activity was eluted at 0.3 and 0.4 M NaCl and markedly inhibited by trifluoperazine and W-7, calmodulin antagonists.	W 7	99-102	calmodulin 1	Rattus norvegicus	0-10
3753505-2	1986	Calmodulin activity was eluted at 0.3 and 0.4 M NaCl and markedly inhibited by trifluoperazine and W-7, calmodulin antagonists.	W 7	99-102	calmodulin 1	Rattus norvegicus	104-114
3082492-6	1986	The increased release of CT induced by 2.5 mM Ca was inhibited 60-90% by 10(-4) M TFP and 10(-4) M W-7, but was unaffected by 10(-4) M CLP or HAL.	W 7	99-102	calcitonin-related polypeptide alpha	Rattus norvegicus	25-27
3008744-3	1986	In contrast, the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) inhibited both oxygen radical generation and lysosomal enzyme release in response to the same stimuli.	W 7	39-90	calmodulin 1	Homo sapiens	17-27
3008744-3	1986	In contrast, the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) inhibited both oxygen radical generation and lysosomal enzyme release in response to the same stimuli.	W 7	92-95	calmodulin 1	Homo sapiens	17-27
3007354-4	1986	Calmodulin-dependent activation of the phosphodiesterase is blocked by both 20 microM trifluoperazine and 20 microM W-7.	W 7	116-119	calmodulin 1	Homo sapiens	0-10
3008985-1	1986	The naphthalene sulfonamide calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide, both induce limited myeloid differentiation of the human promyelocytic cell line, HL-60.	W 7	52-102	calmodulin 1	Homo sapiens	28-38
3735810-1	1986	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a well-known inhibitor of the calmodulin-dependent processes, strongly enhanced phagocytosis and ingestion of polystyrene latex beads into the peritoneal macrophages of BALB/c mice after the i.p.	W 7	0-3	calmodulin 2	Mus musculus	89-99
3735810-1	1986	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a well-known inhibitor of the calmodulin-dependent processes, strongly enhanced phagocytosis and ingestion of polystyrene latex beads into the peritoneal macrophages of BALB/c mice after the i.p.	W 7	5-56	calmodulin 2	Mus musculus	89-99
2418882-1	1986	The LDL receptor synthesis of human skin fibroblasts in the presence of the specific calmodulin antagonists trifluoperazine, condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde (compound 48/80) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) (W-7) was studied.	W 7	221-271	low density lipoprotein receptor	Homo sapiens	4-16
2418882-1	1986	The LDL receptor synthesis of human skin fibroblasts in the presence of the specific calmodulin antagonists trifluoperazine, condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde (compound 48/80) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) (W-7) was studied.	W 7	274-277	low density lipoprotein receptor	Homo sapiens	4-16
3484705-2	1986	Other phenothiazine calmodulin inhibitors, trifluoperazine and chlorpromazine, also intensified the cytotoxic effect of EGF-PE, whereas N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W7) had no such effect.	W 7	189-191	epidermal growth factor	Homo sapiens	120-123
3484629-6	1986	The concentrations of unlabeled bepridil, W-7, prenylamine, verapamil and diltiazem producing 50% inhibition (IC50) of the binding of [3H]bepridil to calmodulin were 4 microM, 28 microM, 45 microM, 130 microM and 700 microM, respectively.	W 7	42-45	calmodulin 1	Homo sapiens	150-160
3080200-4	1986	Calmodulin antagonist, N-(6-aminohexyl)-5-chloronaphthalenesulfonamide hydrochloride (W-7), inhibited the PTZ-induced increased phosphorylation of these two proteins.	W 7	86-89	calmodulin 1	Homo sapiens	0-10
3081414-6	1986	The rise in enzyme activity of CT-treated rats was markedly reduced by the presence of W-7 (10 and 100 microM), a calmodulin inhibitor, in the enzyme assay system, while that of control rats was not significantly altered by the drug.	W 7	87-90	calcitonin-related polypeptide alpha	Rattus norvegicus	31-33
3936721-5	1985	A reagent known to be a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), almost completely inhibited the IL2 mRNA induction in A23187-TPA-stimulated lymphocytes at a concentration of 25 microM, whereas N-(6-aminohexyl)-1-naphthalenesulfonamide that has much lower affinity for calmodulin than W-7 did not inhibit at this concentration.	W 7	47-97	interleukin 2	Homo sapiens	137-140
3484629-8	1986	There was a good correlation between the displacement of [3H]bepridil from calmodulin and the inhibitory effect on MLCK by these calcium channel blockers and W-7.	W 7	158-161	calmodulin 1	Homo sapiens	75-85
3484629-8	1986	There was a good correlation between the displacement of [3H]bepridil from calmodulin and the inhibitory effect on MLCK by these calcium channel blockers and W-7.	W 7	158-161	myosin light chain kinase	Homo sapiens	115-119
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	W 7	0-50	ornithine decarboxylase, structural 1	Mus musculus	77-100
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	W 7	0-50	ornithine decarboxylase, structural 1	Mus musculus	102-105
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	W 7	52-55	ornithine decarboxylase, structural 1	Mus musculus	77-100
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	W 7	52-55	ornithine decarboxylase, structural 1	Mus musculus	102-105
3083437-2	1986	Inhibitory effect of W-7 on TPA-caused ODC induction was also observed in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated skin and even after repetitive TPA treatment.	W 7	21-24	ornithine decarboxylase, structural 1	Mus musculus	39-42
16664387-4	1985	A specific inhibitor of calmodulin N-(6-aminohexyl)5-chloro-1-naphthalenesulfonamide hydrochloride (W-7, a naphthalenesulfonamide derivative) inhibited coleoptile elongation, while its inactive analog N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride (W-5) was ineffective at similar concentrations.	W 7	100-103	calmodulin1	Zea mays	24-34
3936711-1	1985	Trifluoperazine, N-6-aminohexyl-5-chloro-1-naphthalene sulfonamide (W7), and calmidazolium are known to be calmodulin inhibitors and cell membrane soluble substances.	W 7	17-66	calmodulin 1	Homo sapiens	107-117
3936711-1	1985	Trifluoperazine, N-6-aminohexyl-5-chloro-1-naphthalene sulfonamide (W7), and calmidazolium are known to be calmodulin inhibitors and cell membrane soluble substances.	W 7	68-70	calmodulin 1	Homo sapiens	107-117
4028171-5	1985	Macrophage activation was also inhibited by chlorpromazine, W-7, and calmidazolium at concentrations known to perturb calmodulin function.	W 7	60-63	calmodulin 2	Mus musculus	118-128
2995530-3	1985	Two chemically dissimilar inhibitors of calmodulin, namely trifluoperazine and N-(6-amino-hexyl)-5-chloro-1-naphthalenesulphonamide (W-7), attenuated the AVP-, PGE2- and forskolin-stimulated cellular production of cyclic AMP in a dose-related manner.	W 7	133-136	calmodulin 1	Rattus norvegicus	40-50
2995530-5	1985	Basal accumulation of cellular cyclic AMP was also decreased by treatment with either trifluoperazine or W-7, but the effective dose was higher than that which inhibited cellular cyclic AMP production stimulated by AVP, PGE2 and forskolin.	W 7	105-108	arginine vasopressin	Rattus norvegicus	215-218
3000838-3	1985	Two chemically dissimilar inhibitors of calmodulin, namely trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), attenuated the cellular production of cAMP in a dose-related manner in response to all three stimuli.	W 7	79-129	calmodulin 1	Rattus norvegicus	40-50
3000838-3	1985	Two chemically dissimilar inhibitors of calmodulin, namely trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), attenuated the cellular production of cAMP in a dose-related manner in response to all three stimuli.	W 7	131-134	calmodulin 1	Rattus norvegicus	40-50
4020681-0	1985	Pharmacological properties of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist in arterial strips from rats and rabbits.	W 7	30-80	calmodulin 1	Rattus norvegicus	90-100
3080585-6	1986	Calmodulin inhibitors trifluoperazine, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide or calmidazolium diminished PG output and the renal vasoconstriction elicited by NE in the presence and absence of Ca++.	W 7	39-90	calmodulin 1	Rattus norvegicus	0-10
4020681-6	1985	Aortic strip contraction induced by W-7, which has been demonstrated as a calmodulin-independent effect of this compound, was significantly smaller in rats than in rabbits, suggesting that the relaxation of rabbit aorta induced by W-7 was inhibited by its own contractile effect.	W 7	36-39	calmodulin 1	Rattus norvegicus	74-84
4020681-0	1985	Pharmacological properties of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist in arterial strips from rats and rabbits.	W 7	82-85	calmodulin 1	Rattus norvegicus	90-100
4020681-6	1985	Aortic strip contraction induced by W-7, which has been demonstrated as a calmodulin-independent effect of this compound, was significantly smaller in rats than in rabbits, suggesting that the relaxation of rabbit aorta induced by W-7 was inhibited by its own contractile effect.	W 7	231-234	calmodulin 1	Rattus norvegicus	74-84
2989497-6	1985	The inhibitory effects of NE, ME and PE on renin release were blocked significantly by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, but not by N-(6-aminohexyl)-1-naphthalenesulfonamide, which has virtually no calmodulin antagonistic activity.	W 7	87-137	renin	Rattus norvegicus	43-48
2862575-11	1985	In contrast to these findings, the increase in TH phosphorylation brought about by NGF did not require extracellular Ca2+, and was only slightly affected by trifluoperazine or W-7.	W 7	176-179	tyrosine hydroxylase	Rattus norvegicus	47-49
2990581-4	1985	Calmodulin antagonists trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide also inhibit stimulus-induced increases in the NADP + NADPH pool.	W 7	43-94	calmodulin 1	Homo sapiens	0-10
2860207-4	1985	This effect disappeared when drugs (EGTA, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, Gallopamil) preventing Ca2+- and calmodulin-dependent processes were included in the incubating medium.	W 7	42-92	carbonic anhydrase 2	Rattus norvegicus	117-137
3891390-5	1985	Conversely, the calmodulin inhibitor W-7 blocked their appearance and decreased the number of cells containing dots.	W 7	37-40	calmodulin 1	Homo sapiens	16-26
3873667-5	1985	The effect of calmodulin inhibitor (W-7) on skinned preparations was somewhat weaker than that on intact ones.	W 7	36-39	calmodulin-2	Canis lupus familiaris	14-24
2412934-1	1985	Cationic drugs that interact with calmodulin such as chlorpromazine, trifluoperazine, W-7 and lidocaine caused dose-dependent release of mediator from rat mast cells.	W 7	86-89	calmodulin 1	Rattus norvegicus	34-44
3919461-4	1985	Various calmodulin antagonists such as chlorpromazine, trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, not only activated the three reactions but also greatly enhanced their sensitivity to Ca2+ (K0.5, 0.1-0.3 microM).	W 7	75-125	calmodulin	Oryctolagus cuniculus	8-18
4038974-1	1985	The purpose of the present study was to analyse quantitatively the localization of calmodulin antagonist, n-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) in CHO-Kl cells.	W 7	106-157	LOC100759184	Cricetulus griseus	83-93
4038974-1	1985	The purpose of the present study was to analyse quantitatively the localization of calmodulin antagonist, n-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) in CHO-Kl cells.	W 7	159-162	LOC100759184	Cricetulus griseus	83-93
6098542-5	1984	The enzyme activity of CT-treated rats was markedly reduced by W-7 (100 microM), calmodulin inhibitor, while that of control rats was not significantly altered by the drug.	W 7	63-66	calmodulin 1	Rattus norvegicus	81-91
6202384-0	1984	Divergent pharmacological responses to two calmodulin inhibitors, chlorpromazine and W-7, in rat pancreatic acinar cells.	W 7	85-88	calmodulin 1	Rattus norvegicus	43-53
6547673-1	1984	The calmodulin antagonists W-7, trifluoperazine and R24571 in vitro inhibited calmodulin-dependent and independent myosin light chain kinase activity with IC50 values of about 300 microM, 140 microM and 18 microM in the presence of 8 mg/ml myosin light chains.	W 7	27-30	calmodulin 1	Homo sapiens	4-14
6547673-1	1984	The calmodulin antagonists W-7, trifluoperazine and R24571 in vitro inhibited calmodulin-dependent and independent myosin light chain kinase activity with IC50 values of about 300 microM, 140 microM and 18 microM in the presence of 8 mg/ml myosin light chains.	W 7	27-30	calmodulin 1	Homo sapiens	78-88
6547673-1	1984	The calmodulin antagonists W-7, trifluoperazine and R24571 in vitro inhibited calmodulin-dependent and independent myosin light chain kinase activity with IC50 values of about 300 microM, 140 microM and 18 microM in the presence of 8 mg/ml myosin light chains.	W 7	27-30	myosin heavy chain 14	Homo sapiens	115-121
6547673-1	1984	The calmodulin antagonists W-7, trifluoperazine and R24571 in vitro inhibited calmodulin-dependent and independent myosin light chain kinase activity with IC50 values of about 300 microM, 140 microM and 18 microM in the presence of 8 mg/ml myosin light chains.	W 7	27-30	myosin heavy chain 14	Homo sapiens	240-246
6747823-5	1984	Whereas the standard calmodulin antagonist W-7 inhibited both parameters by approximately 50% at 10(-4) M, diazoxide, hydralazine, 3-isobutyl-1-methylxanthine, papaverine, propranolol, nifedipine, nitrendipine, sodium nitroprusside and verapamil did not significantly inhibit either parameter at equimolar concentrations.	W 7	43-46	calmodulin 1	Homo sapiens	21-31
6088755-0	1984	Stimulant effects of W-7, a calmodulin-antagonist, on renin release from rat kidney cortical slices.	W 7	21-24	renin	Rattus norvegicus	54-59
6088755-1	1984	Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin-antagonist, on renin release was examined using rat kidney cortical slices.	W 7	11-61	renin	Rattus norvegicus	97-102
6088755-1	1984	Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin-antagonist, on renin release was examined using rat kidney cortical slices.	W 7	63-66	renin	Rattus norvegicus	97-102
6508780-0	1984	Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.	W 7	13-63	calmodulin 2	Mus musculus	73-83
6508780-0	1984	Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.	W 7	65-68	calmodulin 2	Mus musculus	73-83
6508780-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner.	W 7	25-76	calmodulin 2	Mus musculus	2-12
6508780-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner.	W 7	78-81	calmodulin 2	Mus musculus	2-12
6547949-5	1984	2) Inclusion of trifluoperazine, fluphenazine, W-7, or 10-(3-aminopropyl)-2-(trifluoromethyl)phenothiazine in the reaction mixture protected calmodulin from inactivation by the reagent.	W 7	47-50	calmodulin 1	Homo sapiens	141-151
6735033-1	1984	Quercetin was found to have similar inhibitory effects on tumor promoter-induced phenomena to those of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist.	W 7	103-153	calmodulin 1	Homo sapiens	157-167
6546546-10	1984	Activity in the absence of calmodulin was inhibited at very high concentrations of the "specific" calmodulin antagonists W-7, trifluoperazine and R24571 with apparent IC50 values of 0.3 mM, 0.2 mM and 0.02 mM.	W 7	121-124	calmodulin	Bos taurus	98-108
6202384-2	1984	In this study, two in vitro calmodulin antagonists, W-7 and chlorpromazine, were found to produce both similar and different pharmacological effects on the secretory process in rat exocrine pancreas.	W 7	52-55	calmodulin 1	Rattus norvegicus	28-38
6202384-4	1984	Only W-7 could inhibit the secretory response to vasoactive intestinal peptide (VIP); but both W-7 and chlorpromazine were equipotent partial antagonists of VIP-stimulated cyclic AMP synthesis.	W 7	5-8	vasoactive intestinal peptide	Rattus norvegicus	80-83
6363424-7	1984	Antagonists against calmodulin, including trifluoperazine (1-5 microM) and the naphthalene sulfonamide W-7 (20 microM), also suppressed AChR clustering.	W 7	103-106	calmodulin-1	Xenopus laevis	20-30
6610591-2	1984	Calmodulin inhibitors (trifluoperazine and W-7) also inhibited the mitogenic action of AH-130GF, suggesting that the Ca-calmodulin system and proteolytic processing in lysosomes are necessary for stimulation of DNA synthesis by AH-130GF after its binding to the cell surface.	W 7	43-46	calmodulin 1	Rattus norvegicus	0-10
6610591-2	1984	Calmodulin inhibitors (trifluoperazine and W-7) also inhibited the mitogenic action of AH-130GF, suggesting that the Ca-calmodulin system and proteolytic processing in lysosomes are necessary for stimulation of DNA synthesis by AH-130GF after its binding to the cell surface.	W 7	43-46	calmodulin 1	Rattus norvegicus	120-130
6421505-0	1984	Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.	W 7	39-88	calmodulin 2	Mus musculus	92-102
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	W 7	25-75	calmodulin 2	Mus musculus	2-12
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	W 7	77-80	calmodulin 2	Mus musculus	2-12
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	W 7	58-108	alpha-2-macroglobulin	Homo sapiens	209-230
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	W 7	58-108	epidermal growth factor	Homo sapiens	236-259
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	W 7	58-108	epidermal growth factor	Homo sapiens	261-264
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	W 7	110-113	alpha-2-macroglobulin	Homo sapiens	209-230
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	W 7	110-113	epidermal growth factor	Homo sapiens	236-259
6319437-1	1984	We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.	W 7	110-113	epidermal growth factor	Homo sapiens	261-264
6148310-4	1984	The inhibitory effects of W-7 on slow-reacting substance release could be considered responsible for the suppression of phospholipase A2.	W 7	26-29	phospholipase A2 group IB	Homo sapiens	120-136