PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28413956-4	2017	CONCLUSION: The chemical space of Haspin-targeting low-molecular-weight-compounds has not yet been widely explored, but several scaffolds (e.g., derivatives of acridine, beta-carboline or 5-iodotubercidin) have emerged as promising inhibitors.	norharman	170-184	histone H3 associated protein kinase	Homo sapiens	34-40
26192590-9	2015	In conclusion, we have characterized an optimized beta-carboline inhibitor as a highly selective chemical probe that complies with desirable properties of drug-like molecules and is suitable to interrogate the function of DYRK1A in biological studies.	norharman	50-64	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	222-228
26555243-0	2015	Novel beta-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway.	norharman	6-20	tumor protein p53	Homo sapiens	143-146
27389312-0	2016	Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous beta-carboline norharman: evidence for a novel detoxification pathway.	norharman	79-103	nicotinamide N-methyltransferase	Homo sapiens	0-32
27389312-3	2016	It has been proposed that NNMT may possess beta-carboline (BC) N-methyltransferase activity, endogenously and exogenously produced pyridine-containing compounds which, when N-methylated, are potent inhibitors of Complex I and have been proposed to have a role in the pathogenesis of Parkinson"s disease.	norharman	43-57	nicotinamide N-methyltransferase	Homo sapiens	26-30
27280693-3	2016	Only a few potent and selective ABCG2 inhibitors have been discovered, i.e., fumitremorgin C (FTC), Ko143, and the alkaloid harmine, which contain a tetrahydro-beta-carboline or beta-carboline backbone, respectively.	norharman	160-174	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	32-37
27221219-2	2016	The authors in this highlighted issue describe the synthesis and the photobiological characterizations of two photosensitizer (PS) conjugates based on beta-carboline derivatives covalently conjugated to folic acid (FA) coupled to bovine serum albumin (BSA) as a carrier system specifically targeting cancer cells overexpressing FA receptor alpha (FRalpha).	norharman	151-165	albumin	Homo sapiens	237-250
26526348-1	2015	Harmine, a beta-carboline alkaloid present in Peganum harmala with a wide spectrum of pharmacological activities, has been shown to exert strong inhibition against acetylcholinesterase in vitro.	norharman	11-25	acetylcholinesterase	Mus musculus	164-184
22466726-0	2012	Synthesis and structure of the beta-carboline derivatives and their binding intensity with cyclin-dependent kinase 2.	norharman	31-45	cyclin dependent kinase 2	Homo sapiens	91-116
25770611-7	2015	The presence of norharmane in mixtures of beta-carbolines can be identified based on the difference between the cumulative inhibition of MAO-A by all beta-carbolines and MAO-B inhibition.	norharman	16-26	monoamine oxidase B	Homo sapiens	170-175
23892198-6	2013	KEY FINDINGS: A beta-carboline compound, designated CW108F, increased the number of mouse ESCs expressing alpha-MHC promoter-driven EGFP and the proportion of beating EBs.	norharman	16-30	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	106-115
23117589-0	2012	Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel beta-carboline derivatives.	norharman	98-112	phosphodiesterase 5A	Homo sapiens	14-18
22704238-0	2012	Design, synthesis and biological evaluation of beta-carboline derivatives as novel inhibitors targeting B-Raf kinase.	norharman	47-61	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	104-109
22704238-2	2012	We designed and synthesized two series of novel 1-carboxamide- and 6-sulfonamide-substituted beta-carboline derivatives 7a-p and 12a-b, and their wild type B-Raf kinase inhibitory activities were described.	norharman	93-107	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	156-161
22335895-0	2012	Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.	norharman	41-55	histone H3 associated protein kinase	Mus musculus	71-77
22544982-1	2012	A novel MCAP-cycloaddition sequence has been applied to the facile synthesis of beta-carboline intermediates to gain rapid access to novel derivatives of yohimbine-like and corynanthe-like compounds that may be easily diversified by cross-coupling reactions and N-derivatizations to generate small compound libraries.	norharman	80-94	bromodomain containing 4	Homo sapiens	8-12
25770611-6	2015	The MAO-A is inhibited by all three tested beta-carbolines (harmane, norharmane, and harmaline) while MAO-B is inhibited only by norharmane.	norharman	69-79	monoamine oxidase A	Homo sapiens	4-9
25770611-6	2015	The MAO-A is inhibited by all three tested beta-carbolines (harmane, norharmane, and harmaline) while MAO-B is inhibited only by norharmane.	norharman	129-139	monoamine oxidase B	Homo sapiens	102-107
25770611-7	2015	The presence of norharmane in mixtures of beta-carbolines can be identified based on the difference between the cumulative inhibition of MAO-A by all beta-carbolines and MAO-B inhibition.	norharman	16-26	monoamine oxidase A	Homo sapiens	137-142
25541203-0	2015	Selective binding to monoamine oxidase A: in vitro and in vivo evaluation of (18)F-labeled beta-carboline derivatives.	norharman	91-105	monoamine oxidase A	Homo sapiens	21-40
25502825-1	2015	The potent alpha-glucosidase inhibitor (compound I) was isolated from coffee brews by the activity-based fractionation and identified as a beta-carboline alkaloid norharman (9H-pyrido[ 3.4-b]indole) on the basis of mass spectroscopy and nuclear magnetic resonance spectra ((1)H NMR, (13)C NMR, and COSY).	norharman	163-172	sucrase-isomaltase	Homo sapiens	11-28
25502825-2	2015	The norharman showed a potent inhibition against alpha-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively.	norharman	4-13	sucrase-isomaltase	Homo sapiens	49-66
25502825-3	2015	A Lineweaver-Burk plot revealed that norharman inhibited alpha-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM.	norharman	37-46	sucrase-isomaltase	Homo sapiens	57-74
23708826-8	2013	The observation of the (SCN)2( -) transient in microemulsions demonstrates that it is possible to have the protonated beta-carboline and at least two thiocyanate ions in the same water pool.	norharman	118-132	growth factor independent 1 transcriptional repressor	Homo sapiens	24-29
21992679-4	2012	R-Deprenyl, a known neuroprotectant, norharman (beta-carboline), 5-nitroindazole and menadione (vitamin K3) inhibited MAO-B and reduced the formation of toxic pyridinium cations.	norharman	37-46	monoamine oxidase B	Homo sapiens	118-123
21992679-4	2012	R-Deprenyl, a known neuroprotectant, norharman (beta-carboline), 5-nitroindazole and menadione (vitamin K3) inhibited MAO-B and reduced the formation of toxic pyridinium cations.	norharman	48-62	monoamine oxidase B	Homo sapiens	118-123
21992679-5	2012	Clorgyline and the beta-carbolines, harman and norharman, inhibited the oxidation of MPTP by MAO-A.	norharman	47-56	monoamine oxidase A	Homo sapiens	93-98
21992679-6	2012	Cigarette smoke, as well as the naturally occurring beta-carbolines (norharman and harman) isolated from smoke and coffee inhibited the oxidation of MPTP by MAO-B and/or MAO-A, suggesting protective effects against MPTP.	norharman	69-78	monoamine oxidase B	Homo sapiens	157-162
21992679-6	2012	Cigarette smoke, as well as the naturally occurring beta-carbolines (norharman and harman) isolated from smoke and coffee inhibited the oxidation of MPTP by MAO-B and/or MAO-A, suggesting protective effects against MPTP.	norharman	69-78	monoamine oxidase A	Homo sapiens	170-175
21818552-3	2012	NQO1 utilizes NAD(P)H, whereas NQO2 employs dihydronicotinamide riboside (NRH) as the electron donors.	norharman	74-77	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	31-35
22466726-2	2012	In addition, the binding mode of these beta-carboline derivatives with cyclin-dependent kinase 2 (CDK2) was studied by means of fluorescence measurements and molecular docking calculation.	norharman	39-53	cyclin dependent kinase 2	Homo sapiens	71-96
22466726-2	2012	In addition, the binding mode of these beta-carboline derivatives with cyclin-dependent kinase 2 (CDK2) was studied by means of fluorescence measurements and molecular docking calculation.	norharman	39-53	cyclin dependent kinase 2	Homo sapiens	98-102
23056340-3	2012	In this paper, a series of beta-carboline derivatives were synthesized and three compounds, DH281, DH285 and DH287, were identified as potent new PLK inhibitors.	norharman	27-41	polo like kinase 1	Homo sapiens	146-149
23056340-10	2012	Together, these results demonstrate that DH281, DH285 and DH287 beta-carboline compounds are new PLK inhibitors with potential for cancer treatment.	norharman	64-78	polo like kinase 1	Homo sapiens	97-100
21631432-4	2011	Uniquely, when overexpressed in bacteria, family members GSTF2 and GSTF3 bound a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde.	norharman	146-156	glutathione S-transferase PHI 2	Arabidopsis thaliana	57-62
21631432-4	2011	Uniquely, when overexpressed in bacteria, family members GSTF2 and GSTF3 bound a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde.	norharman	146-156	glutathione S-transferase F3	Arabidopsis thaliana	67-72
21573099-0	2011	beta-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer"s disease-related sites.	norharman	0-14	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	53-59
21504804-3	2011	Orphan ligand library screening using this system identified the beta-carboline derivative harmine, which is a highly potent inhibitor of dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), to be an NFAT regulator in osteoclasts.	norharman	65-79	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	138-199
21504804-3	2011	Orphan ligand library screening using this system identified the beta-carboline derivative harmine, which is a highly potent inhibitor of dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), to be an NFAT regulator in osteoclasts.	norharman	65-79	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	201-207
21554916-4	2011	Methylene blue, 5-nitroindazole, norharman (beta-carboline), 9-methylnorharman (9-methyl-beta-carboline) and menadione (vitamin-K analogue) highly inhibited the oxidation of MPTP to the neurotoxic species, MPDP+/MPP+, in human mitochondria (IC50 of 0.18, 3.1, 9.9, 7.3, and 12.6 muM, respectively).	norharman	33-42	latexin	Homo sapiens	279-282
21554916-4	2011	Methylene blue, 5-nitroindazole, norharman (beta-carboline), 9-methylnorharman (9-methyl-beta-carboline) and menadione (vitamin-K analogue) highly inhibited the oxidation of MPTP to the neurotoxic species, MPDP+/MPP+, in human mitochondria (IC50 of 0.18, 3.1, 9.9, 7.3, and 12.6 muM, respectively).	norharman	44-58	latexin	Homo sapiens	279-282
21554916-8	2011	Norharman and 5-nitroindazole were competitive inhibitors of MAO-B whereas methylene blue inhibited MPTP oxidation (IC50 of 50 nM) under a mixed type and predominantly uncompetitive mechanism.	norharman	0-9	monoamine oxidase B	Homo sapiens	61-66
21554916-9	2011	Methylene blue, 5-nitroindazole, norharman, 9-methylnorharman and menadione inhibit MAO-B in mitochondria and afford protective effects, as suggested by a reduced conversion of MPTP to neurotoxic species.	norharman	33-42	monoamine oxidase B	Homo sapiens	84-89
21573099-0	2011	beta-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer"s disease-related sites.	norharman	0-14	microtubule associated protein tau	Homo sapiens	64-67
21573099-1	2011	Harmine, a beta-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein.	norharman	11-25	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	72-133
21573099-1	2011	Harmine, a beta-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein.	norharman	11-25	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	135-141
21573099-5	2011	Here we test the ability of harmine, and numerous additional beta-carboline compounds, to inhibit the DYRK1A dependent phosphorylation of tau protein on serine 396, serine 262/serine 356 (12E8 epitope), and threonine 231 in cell culture assays and in vitro phosphorylation assays.	norharman	61-75	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	102-108
21573099-5	2011	Here we test the ability of harmine, and numerous additional beta-carboline compounds, to inhibit the DYRK1A dependent phosphorylation of tau protein on serine 396, serine 262/serine 356 (12E8 epitope), and threonine 231 in cell culture assays and in vitro phosphorylation assays.	norharman	61-75	microtubule associated protein tau	Homo sapiens	138-141
21573099-6	2011	Results demonstrate that the beta-carboline compounds (1) potently reduce the expression of all three phosphorylated forms of tau protein, and (2) inhibit the DYRK1A catalyzed direct phosphorylation of tau protein on serine 396.	norharman	29-43	microtubule associated protein tau	Homo sapiens	126-129
21573099-6	2011	Results demonstrate that the beta-carboline compounds (1) potently reduce the expression of all three phosphorylated forms of tau protein, and (2) inhibit the DYRK1A catalyzed direct phosphorylation of tau protein on serine 396.	norharman	29-43	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	159-165
21573099-6	2011	Results demonstrate that the beta-carboline compounds (1) potently reduce the expression of all three phosphorylated forms of tau protein, and (2) inhibit the DYRK1A catalyzed direct phosphorylation of tau protein on serine 396.	norharman	29-43	microtubule associated protein tau	Homo sapiens	202-205
21573099-7	2011	By assaying several beta-carboline compounds, we define certain chemical groups that modulate the affinity of this class of compounds for inhibition of tau phosphorylation.	norharman	20-34	microtubule associated protein tau	Homo sapiens	152-155
21316977-4	2011	Moreover, compounds 6 and 16 significantly reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2), suggesting that beta-carboline analogs can inhibit NO and PGE(2) production at the translational level.	norharman	153-167	nitric oxide synthase 2	Homo sapiens	69-100
21485291-1	2011	The investigated beta-carboline derivatives were synthesized to elucidate their activity as 5-HT(1A) and 5-HT(2A) receptor ligands.	norharman	17-31	5-hydroxytryptamine receptor 1A	Homo sapiens	92-99
21332190-0	2011	beta-carboline derivatives and diphenols from soy sauce are in vitro quinone reductase (QR) inducers.	norharman	0-14	crystallin, zeta	Mus musculus	69-86
21332190-0	2011	beta-carboline derivatives and diphenols from soy sauce are in vitro quinone reductase (QR) inducers.	norharman	0-14	crystallin, zeta	Mus musculus	88-90
21316977-4	2011	Moreover, compounds 6 and 16 significantly reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2), suggesting that beta-carboline analogs can inhibit NO and PGE(2) production at the translational level.	norharman	153-167	nitric oxide synthase 2	Homo sapiens	102-106
21316977-4	2011	Moreover, compounds 6 and 16 significantly reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2), suggesting that beta-carboline analogs can inhibit NO and PGE(2) production at the translational level.	norharman	153-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	112-128
21316977-4	2011	Moreover, compounds 6 and 16 significantly reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2), suggesting that beta-carboline analogs can inhibit NO and PGE(2) production at the translational level.	norharman	153-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	130-134
20449727-7	2010	The toxicological relevance of beta-carboline-mediated AhR activation is discussed.	norharman	31-45	aryl hydrocarbon receptor	Homo sapiens	55-58
20361801-6	2010	The most promising compound was a N(9)-homobivalent beta-carboline with a nonylene spacer, which displayed IC(50) values of 0.5 nM for AChE, 5.7 nM for BChE, and 1.4 microM for NR, respectively.	norharman	52-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
20361801-6	2010	The most promising compound was a N(9)-homobivalent beta-carboline with a nonylene spacer, which displayed IC(50) values of 0.5 nM for AChE, 5.7 nM for BChE, and 1.4 microM for NR, respectively.	norharman	52-66	butyrylcholinesterase	Homo sapiens	152-156
19855194-0	2009	DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1.	norharman	9-23	polo like kinase 1	Homo sapiens	68-72
21117497-0	2010	Arylalkylamine-, beta-carboline-, quinolizine- and azecine-derived compounds and their in vitro interaction with the ionotropic 5-HT3 receptor: search for new lead structures.	norharman	17-31	5-hydroxytryptamine receptor 3A	Rattus norvegicus	128-142
19855194-5	2009	We found that DH166, a beta-carboline derivative, inhibits the growth of cdc5-2 temperature-sensitive mutant more profoundly than wild-type yeast cells.	norharman	23-37	cell division cycle 5 like	Homo sapiens	73-77
19855194-9	2009	Although beta-carboline derivatives have been demonstrated to show antitumor activities through multiple mechanisms, our data indicate for the first time that their cytotoxicity to tumor cells might be attributable to the inhibition of PLK1 as well.	norharman	9-23	polo like kinase 1	Homo sapiens	236-240
17256107-4	2007	Dopamine melanin protected against norharman-induced upregulation of grp78, activation of caspase 3 and necrosis at low concentrations (5 and 50 microM).	norharman	35-44	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	69-74
18663430-2	2008	Mana-Hox is a synthetic derivative of beta-carboline, a structure relevant to marine sponge component, manzamine.	norharman	38-52	mannosidase alpha class 2C member 1	Homo sapiens	0-4
18457825-8	2008	These results suggest that harman and norharman inhibit dopamine biosynthesis by reducing TH activity and enhance L-DOPA-induced cytotoxicity in PC12 cells.	norharman	38-47	tyrosine hydroxylase	Rattus norvegicus	90-92
17256107-4	2007	Dopamine melanin protected against norharman-induced upregulation of grp78, activation of caspase 3 and necrosis at low concentrations (5 and 50 microM).	norharman	35-44	caspase 3	Rattus norvegicus	90-99
17229101-6	2006	Taken together, these results indicate that MAO-A inhibition interacts with nicotine to enhance its rewarding effects in rats and suggest that other compounds present in tobacco, such as beta-carboline, may also play an important role in sustaining smoking behavior in humans.	norharman	187-201	monoamine oxidase A	Rattus norvegicus	44-49
17276684-1	2007	Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was designed by replacement of the pyrrole core with an indole scaffold and consequent cyclization of the C-2 position into a tricyclic beta-carboline template.	norharman	223-237	glutamate metabotropic receptor 1	Homo sapiens	68-74
17276684-1	2007	Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was designed by replacement of the pyrrole core with an indole scaffold and consequent cyclization of the C-2 position into a tricyclic beta-carboline template.	norharman	223-237	complement C2	Homo sapiens	193-196
17315924-1	2007	A photophysical study on the binding interaction of an efficient cancer cell photosensitizer, norharmane (NHM), with model transport proteins, bovine serum albumin (BSA) and human serum albumin (HSA), has been performed using a combination of steady-state and time-resolved fluorescence techniques.	norharman	94-104	albumin	Homo sapiens	150-169
17315924-1	2007	A photophysical study on the binding interaction of an efficient cancer cell photosensitizer, norharmane (NHM), with model transport proteins, bovine serum albumin (BSA) and human serum albumin (HSA), has been performed using a combination of steady-state and time-resolved fluorescence techniques.	norharman	94-104	albumin	Homo sapiens	150-163
17268643-0	2006	Synthesis, crystal structure and biological activity of beta-carboline based selective CDK4-cyclin D1 inhibitors.	norharman	56-70	cyclin dependent kinase 4	Homo sapiens	87-91
17268643-0	2006	Synthesis, crystal structure and biological activity of beta-carboline based selective CDK4-cyclin D1 inhibitors.	norharman	56-70	cyclin D1	Homo sapiens	92-101
16945113-6	2006	The inhibition of nNOS elicited by melatonin, but not by AMK, was blocked with 0.05 mm norharmane, an indoleamine-2,3-dioxygenase inhibitor.	norharman	87-97	nitric oxide synthase 1	Rattus norvegicus	18-22
16945529-2	2006	6-Oxygenated beta-carboline and beta-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively.	norharman	13-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-163
16945529-2	2006	6-Oxygenated beta-carboline and beta-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively.	norharman	13-27	butyrylcholinesterase	Homo sapiens	168-172
16870220-0	2006	Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.	norharman	104-118	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	156-175
16945113-8	2006	Also, in vivo, the administration of norharmane blocked the inhibition of nNOS produced by melatonin administration, but not the inhibition produced by AMK.	norharman	37-47	nitric oxide synthase 1	Rattus norvegicus	74-78
16242163-1	2006	The endogenous beta-carboline, harmane, has been shown to bind to monoamine oxidase A (MAO-A) and a separate, high affinity, non-MAO site.	norharman	15-29	monoamine oxidase A	Rattus norvegicus	66-85
16765324-1	2006	NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as electron donor.	norharman	0-3	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	30-34
16525037-3	2006	Here, we report the mechanism and the effect of the IKKbeta inhibitor N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide (ML120B), a beta-carboline derivative, on NF-kappaB signaling and gene activation in RA-relevant cell systems.	norharman	148-162	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	52-59
16075188-5	2006	In cultured PC12 cells norharman treatment induced mitochondrial dysfunction and increased the number of caspase-3 and TUNEL-positive cells.	norharman	23-32	caspase 3	Rattus norvegicus	105-114
16242163-1	2006	The endogenous beta-carboline, harmane, has been shown to bind to monoamine oxidase A (MAO-A) and a separate, high affinity, non-MAO site.	norharman	15-29	monoamine oxidase A	Rattus norvegicus	87-92
16242163-1	2006	The endogenous beta-carboline, harmane, has been shown to bind to monoamine oxidase A (MAO-A) and a separate, high affinity, non-MAO site.	norharman	15-29	monoamine oxidase A	Rattus norvegicus	87-90
16139309-5	2006	Subsequently, the pyrido-indole (beta-carboline) alkaloids, norharman and harman, were identified and isolated from MAO-inhibiting coffee, and were good inhibitors on MAO A (harman and norharman) and MAO B (norharman) isozymes.	norharman	60-69	monoamine oxidase A	Homo sapiens	167-172
16139309-5	2006	Subsequently, the pyrido-indole (beta-carboline) alkaloids, norharman and harman, were identified and isolated from MAO-inhibiting coffee, and were good inhibitors on MAO A (harman and norharman) and MAO B (norharman) isozymes.	norharman	60-69	monoamine oxidase B	Homo sapiens	200-205
16139309-5	2006	Subsequently, the pyrido-indole (beta-carboline) alkaloids, norharman and harman, were identified and isolated from MAO-inhibiting coffee, and were good inhibitors on MAO A (harman and norharman) and MAO B (norharman) isozymes.	norharman	185-194	monoamine oxidase A	Homo sapiens	167-172
16139309-5	2006	Subsequently, the pyrido-indole (beta-carboline) alkaloids, norharman and harman, were identified and isolated from MAO-inhibiting coffee, and were good inhibitors on MAO A (harman and norharman) and MAO B (norharman) isozymes.	norharman	185-194	monoamine oxidase A	Homo sapiens	167-172
16356849-0	2005	The beta-carboline analog Mana-Hox causes mitotic aberration by interacting with DNA.	norharman	4-18	mannosidase alpha class 2C member 1	Homo sapiens	26-30
16133137-3	2005	Harmane and norharmane are inhibitors of the monoamine oxidases A (MAO-A) and B (MAO-B), respectively.	norharman	12-22	monoamine oxidase A	Rattus norvegicus	45-65
16133137-3	2005	Harmane and norharmane are inhibitors of the monoamine oxidases A (MAO-A) and B (MAO-B), respectively.	norharman	12-22	monoamine oxidase A	Rattus norvegicus	67-79
16133137-3	2005	Harmane and norharmane are inhibitors of the monoamine oxidases A (MAO-A) and B (MAO-B), respectively.	norharman	12-22	monoamine oxidase B	Rattus norvegicus	81-86
15582589-8	2005	Norharman was an inhibitor of MAO-A (K(i)=1.2+/-0.18 microM) and MAO-B (K(i)=1.12+/-0.19 microM), and harman of MAO-A (K(i)=55.54+/-5.3nM).	norharman	0-9	monoamine oxidase A	Homo sapiens	30-35
16061219-0	2005	High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.	norharman	96-105	monoamine oxidase A	Rattus norvegicus	74-79
15588121-0	2005	Photophysics in motionally constrained bioenvironment: interaction of norharmane with bovine serum albumin.	norharman	70-80	albumin	Homo sapiens	93-106
15582589-8	2005	Norharman was an inhibitor of MAO-A (K(i)=1.2+/-0.18 microM) and MAO-B (K(i)=1.12+/-0.19 microM), and harman of MAO-A (K(i)=55.54+/-5.3nM).	norharman	0-9	monoamine oxidase B	Homo sapiens	65-70
15582589-8	2005	Norharman was an inhibitor of MAO-A (K(i)=1.2+/-0.18 microM) and MAO-B (K(i)=1.12+/-0.19 microM), and harman of MAO-A (K(i)=55.54+/-5.3nM).	norharman	0-9	monoamine oxidase A	Homo sapiens	112-117
15279827-11	2004	Based on these observations, it is suggested that the practical major contributors to the formation of APNH from norharman and aniline are CYP3A4 and CYP1A2, the responsible reactions mainly occurring in the liver.	norharman	113-122	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145
15279827-5	2004	The amounts of APNH from norharman and aniline were 33 ng for CYP1A1, 15 ng for CYP3A4, 7 ng for CYP2D6, 6 ng for CYP1A2 and 5 ng for CYP2B6.	norharman	25-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-86
15279827-11	2004	Based on these observations, it is suggested that the practical major contributors to the formation of APNH from norharman and aniline are CYP3A4 and CYP1A2, the responsible reactions mainly occurring in the liver.	norharman	113-122	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	150-156
15279827-5	2004	The amounts of APNH from norharman and aniline were 33 ng for CYP1A1, 15 ng for CYP3A4, 7 ng for CYP2D6, 6 ng for CYP1A2 and 5 ng for CYP2B6.	norharman	25-34	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	97-103
14665639-8	2004	The spectroscopy and biochemistry of AOX1 are very similar to those of AOH1 except for a differential sensitivity to the non-competitive inhibitory effect of norharmane.	norharman	158-168	aldehyde oxidase 1	Mus musculus	37-41
15149658-0	2004	Synthesis and biological evaluation of novel beta-carboline derivatives as Tat-TAR interaction inhibitors.	norharman	45-59	RNA binding motif protein 8A	Homo sapiens	79-82
15149658-1	2004	Four new beta-carboline derivatives were synthesized bearing guanidinium group or amino group-terminated side chain targeting the TAR element.	norharman	9-23	RNA binding motif protein 8A	Homo sapiens	130-133
14529407-14	2003	This is NQO2--an enzyme that requires for activity, the non-biogenic compound dihydronicotinamide riboside (NRH) as a cosubstrate.	norharman	108-111	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	8-12
14660022-3	2003	The beta-carbolines harmane, norharmane and pinoline increased insulin secretion two- to threefold from isolated human islets of Langerhans.	norharman	29-39	insulin	Homo sapiens	63-70
14568301-0	2003	Possibility of the involvement of 9H-pyrido[3,4-b]indole (norharman) in carcinogenesis via inhibition of cytochrome P450-related activities and intercalation to DNA.	norharman	58-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	105-120
14568301-1	2003	This study investigated the inhibitory effect of 9H-pyrido[3,4-b]indole (norharman), one of the naturally occurring beta-carbolines, on cytochrome P450 (CYP)-related activities and the relationship between its inhibitory effect, its intercalation to DNA, and its comutagenic effect.	norharman	73-82	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	136-151
14568301-1	2003	This study investigated the inhibitory effect of 9H-pyrido[3,4-b]indole (norharman), one of the naturally occurring beta-carbolines, on cytochrome P450 (CYP)-related activities and the relationship between its inhibitory effect, its intercalation to DNA, and its comutagenic effect.	norharman	73-82	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	153-156
14568301-3	2003	Norharman inhibited microsomal CYP-related enzyme activities and CO-binding to the CYP heme (50% inhibitory concentration (IC50), 0.07-6.4 microg/ml).	norharman	0-9	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	31-34
14568301-3	2003	Norharman inhibited microsomal CYP-related enzyme activities and CO-binding to the CYP heme (50% inhibitory concentration (IC50), 0.07-6.4 microg/ml).	norharman	0-9	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-86
14568301-6	2003	These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA.	norharman	26-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-67
14568301-6	2003	These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA.	norharman	26-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	138-141
14568301-6	2003	These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA.	norharman	26-35	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	138-141
12824047-4	2003	In addition, we show that one of these beta-carboline analogues inhibits the phosphorylation of IkappaBalpha and subsequent activation of NF-kappaB in whole cells, as well as blocking TNF-alpha release in LPS-challenged mice.	norharman	39-53	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	96-108
12824047-4	2003	In addition, we show that one of these beta-carboline analogues inhibits the phosphorylation of IkappaBalpha and subsequent activation of NF-kappaB in whole cells, as well as blocking TNF-alpha release in LPS-challenged mice.	norharman	39-53	tumor necrosis factor	Mus musculus	184-193
12668004-1	2003	The SAR of a series of beta-carboline derived type 5 phosphodiesterase inhibitors has been explored and we have discovered compounds with excellent levels of PDE5 potency and selectivity over PDE6.	norharman	23-37	sarcosine dehydrogenase	Homo sapiens	4-7
12668004-1	2003	The SAR of a series of beta-carboline derived type 5 phosphodiesterase inhibitors has been explored and we have discovered compounds with excellent levels of PDE5 potency and selectivity over PDE6.	norharman	23-37	phosphodiesterase 5A	Homo sapiens	158-162
12970073-0	2003	Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse.	norharman	34-43	glutamic pyruvic transaminase, soluble	Mus musculus	110-113
11900856-5	2002	LY134046, a selective inhibitor of phenylethanolamine N-methyltransferase, inhibits (IC50 1.9 microM) the 2N-methylation of 9-methylnorharman, a substrate for beta-carboline 2N-methyltransferase.	norharman	159-173	phenylethanolamine N-methyltransferase	Homo sapiens	35-73
11900856-6	2002	Substrates of phenylethanolamine N-methyltransferase also inhibit beta-carboline 2N-methyltransferase activity in a concentration-dependent manner.	norharman	66-80	phenylethanolamine N-methyltransferase	Homo sapiens	14-52
11900856-7	2002	beta-Carboline 2N-methyltransferase activity (43.7pmol/h/mg protein) is present in human adrenal medulla, a tissue with high phenylethanolamine N-methyltransferase activity.	norharman	0-14	phenylethanolamine N-methyltransferase	Homo sapiens	125-163
11688992-2	2001	Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism.	norharman	152-155	glutathione S-transferase mu 1	Homo sapiens	70-75
11688992-2	2001	Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism.	norharman	152-155	NAD(P)H quinone dehydrogenase 1	Homo sapiens	112-116
11688992-2	2001	Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism.	norharman	152-155	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	183-187
10063485-1	1999	The benzodiazepines flunitrazepam, diazepam, and Ro 15-1788 and the beta-carboline DMCM bind with equivalent affinity to the benzodiazepine binding site of GABAA receptors containing different alpha subunits (i.e., alpha 1, alpha 2, alpha 3, or alpha 5); whereas, the triazolopyridazine CL 218,872 and imidazopyridine zolpidem have higher affinity for alpha 1 subunit-containing GABAA receptors.	norharman	68-82	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	224-252
11154737-6	2000	NQO2 uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.	norharman	40-43	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	0-4
10945627-7	2000	The enzyme is NQO2 [NAD(P)H quinone oxidoreductase 2], but its activity is normally latent, and a nonbiogenic co-substrate such as NRH [nicotinamide riboside (reduced)] is required for enzymatic activity.	norharman	131-134	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	14-18
10945627-7	2000	The enzyme is NQO2 [NAD(P)H quinone oxidoreductase 2], but its activity is normally latent, and a nonbiogenic co-substrate such as NRH [nicotinamide riboside (reduced)] is required for enzymatic activity.	norharman	131-134	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	20-52
10864139-5	2000	These results suggest that halogens at the C-5 and C-7 positions in the beta-carboline skeleton are essential for Ca2+-releasing activity and that an N-9 methyl group also affects the activity of these analogues.	norharman	72-86	complement C5	Homo sapiens	43-46
10864139-5	2000	These results suggest that halogens at the C-5 and C-7 positions in the beta-carboline skeleton are essential for Ca2+-releasing activity and that an N-9 methyl group also affects the activity of these analogues.	norharman	72-86	complement C7	Homo sapiens	51-54
10947071-3	2000	Macrophage exposure to norharmane, an IDO inhibitor, resulted in a decreased formation of not only the kynurenine metabolites but also NO.	norharman	23-33	indoleamine 2,3-dioxygenase 1	Mus musculus	38-41
9952314-7	1999	It was displaceable by ethanol (Ki 14.25 microM), indicating that norharman and ethanol bind to the same binding site on CYP2E1.	norharman	66-75	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	121-127
7617701-6	1995	Finally, administration of the anxiogenic beta-carboline, FG-7142, causes increases in both hippocampus and adrenal gland PBR binding reminiscent of acute noise stress exposure.	norharman	42-56	translocator protein	Homo sapiens	122-125
10721096-7	1999	In vivo inhibition of IDO by norharman provokes a dramatic increase in circulating parasite number.	norharman	29-38	indoleamine 2,3-dioxygenase 1	Homo sapiens	22-25
9711973-5	1998	Based on converging evidence, the view is advanced that endogenous, genetically based (excessive) formation, or accumulation, of toxic DA transporter substrates, such as isoquinoline or beta-carboline derivatives, may in fact represent the primary cause of substantia nigra cell degeneration in patients with PD.	norharman	186-200	solute carrier family 6 member 3	Homo sapiens	135-149
8990278-0	1997	Inhibition of monoamine oxidase A by beta-carboline derivatives.	norharman	37-51	monoamine oxidase A	Homo sapiens	14-33
8990278-2	1997	The interaction of nine beta-carboline derivatives and four 3,4-dihydro forms with purified MAO A was investigated.	norharman	24-38	monoamine oxidase A	Homo sapiens	92-97
26964656-3	1996	In higher doses norharman binds to benzodiazepine receptors and has MAO-B inhibitory activity.	norharman	16-25	monoamine oxidase B	Homo sapiens	68-73
7657995-5	1995	For two of these strains, we obtained significant results showing that genes located on chromosomes 4 and 13, provisionally termed respectively Bis1 and Bis2, were involved in the regulation of beta-carboline-induced seizures.	norharman	194-208	beta-carboline-induced seizures 1	Mus musculus	144-148
7657995-5	1995	For two of these strains, we obtained significant results showing that genes located on chromosomes 4 and 13, provisionally termed respectively Bis1 and Bis2, were involved in the regulation of beta-carboline-induced seizures.	norharman	194-208	beta-carboline-induced seizures 2	Mus musculus	153-157
9367528-4	1997	Interestingly, NQO2 uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.	norharman	55-58	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	15-19
9367528-21	1997	hNQO2-hDT43 still uses NRH as an electron donor.	norharman	23-26	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	0-5
7787685-1	1995	The nootropic agents pyracetam, ethymisole, N-5-oxynicotinoyl glutamate and beta-carboline derivative--ambocarb--enhance short-term potentiation of populational EPSP"s amplitude of area CA1 pyramidal neurons in the slices of the rat hippocampus, which is evoked by NMDA.	norharman	76-90	carbonic anhydrase 1	Rattus norvegicus	186-189
7780638-13	1995	Among beta-carboline analogues, methyl-beta-carboline-3-carboxylate and propyl-beta-carboline-3-carboxylate markedly enhanced GABA-induced Cl currents in the alpha 1 beta 2 gamma 2 subtype, while N-methyl-beta-carboline-3-carboxamide and 1-methyl-7-methoxy-3,4-dihydro-beta-carboline did not.	norharman	6-20	adrenoceptor alpha 1D	Homo sapiens	158-180
8119304-0	1993	Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17).	norharman	0-9	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	103-108
8119304-0	1993	Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17).	norharman	11-25	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	103-108
8119304-3	1993	Progesterone binding to CYP17 is competitively inhibited, with Ki = 2.6 microM norharman, whereas harman, tetrahydronorharman and tetrahydroharman are nearly ineffective.	norharman	79-88	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	24-29
8121637-0	1993	1-Methyl-4-phenylpyridinium (MPP+) binds with high affinity to a beta-carboline binding site located on monoamine oxidase type A in rat brain.	norharman	65-79	monoamine oxidase A	Rattus norvegicus	104-128
8232719-1	1993	In addition to the known binding of norharman (NH) to monoamine oxidase (MAO) and benzodiazepine (BZ) binding sites (at microM concentrations), a distinct class of high-affinity NH binding sites was discovered in rat brain.	norharman	36-45	monoamine oxidase A	Rattus norvegicus	54-71
8232719-1	1993	In addition to the known binding of norharman (NH) to monoamine oxidase (MAO) and benzodiazepine (BZ) binding sites (at microM concentrations), a distinct class of high-affinity NH binding sites was discovered in rat brain.	norharman	36-45	monoamine oxidase A	Rattus norvegicus	73-76
8471029-0	1993	4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).	norharman	55-65	interferon gamma	Homo sapiens	105-121
8471029-0	1993	4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).	norharman	55-65	GLI family zinc finger 2	Homo sapiens	144-149
8471029-4	1993	Norharmane, 6-chloro-DL-tryptophan and 4-chloro-3-hydroxyanthranilate attenuated quinolinic acid formation by THP-1 cells with IC50 values of 51 microM, 58 microM and 0.11 microM respectively.	norharman	0-10	GLI family zinc finger 2	Homo sapiens	110-115
8471029-6	1993	The reductions in L-kynurenine and quinolinic acid formation are consistent with the reports that norharmane is an inhibitor of indoleamine 2,3-dioxygenase, 6-chloro-DL-tryptophan is metabolized through the kynurenine pathway, and 4-chloro-3-hydroxyanthranilate is an inhibitor of 3-hydroxyanthranilate 3,4-dioxygenase.	norharman	98-108	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	281-318
1668366-4	1991	Administration of the anxiogenic beta-carboline FG 7142 also increased the total number of VTA DA neurons expressing Fos protein, whereas pretreatment with an anxiolytic benzodiazepine (diazepam) partially prevented the stress-induced increase in Fos expression.	norharman	33-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
1668366-4	1991	Administration of the anxiogenic beta-carboline FG 7142 also increased the total number of VTA DA neurons expressing Fos protein, whereas pretreatment with an anxiolytic benzodiazepine (diazepam) partially prevented the stress-induced increase in Fos expression.	norharman	33-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	247-250
34753060-0	2021	beta-Carboline tethered cinnamoyl 2-aminobenzamides as class I selective HDAC inhibitors: Design, synthesis, biological activities and modelling studies.	norharman	0-14	histone deacetylase 9	Homo sapiens	73-77
32794745-3	2020	Herein, we report the preparation of ten copper complexes with 9-substituted beta-carboline ligands that act as metal-based Mcl-1 inhibitors.	norharman	77-91	myeloid cell leukemia sequence 1	Mus musculus	124-129
34753060-1	2021	The effect of beta-carboline motif as cap for HDAC inhibitors containing cinnamic acid as linker and benzamides as zinc binding group was examined in this study.	norharman	14-28	histone deacetylase 9	Homo sapiens	46-50
34753060-2	2021	A series of beta-carboline-cinnamide conjugates have been synthesized and evaluated for their HDAC inhibitory activity and in vitro cytotoxicity against different human cancer cell lines.	norharman	12-26	histone deacetylase 9	Homo sapiens	94-98
34459988-0	2021	Cyclometalated Ru(II) beta-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling.	norharman	22-36	mitogen-activated protein kinase 1	Homo sapiens	138-141
34806016-3	2021	Supplementation with the NAD+ precursor dihydronicotinamide riboside (NRH) rapidly increased NAD+ levels in GSCs and glioma cells, inducing PARP1 activation and mild suppression of replication fork progression.	norharman	70-73	poly(ADP-ribose) polymerase 1	Homo sapiens	140-145
34459988-0	2021	Cyclometalated Ru(II) beta-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling.	norharman	22-36	AKT serine/threonine kinase 1	Homo sapiens	146-149
35180487-1	2022	Cyclin-dependent kinase 4 (CDK4), which is involved in dynamic regulation of cell cycle, has gained particularly attention for its role in controlling tumor growth.Increasing evidence showed that beta-carboline derivatives have the potential to inhibit CDK4.	norharman	196-210	cyclin dependent kinase 4	Homo sapiens	0-25
34602411-0	2021	Effects of beta-carboline alkaloids from Peganum harmala on the FAK/PI3K/AKT/Mtor pathway in human gastric cancer cell line SGC-7901 and tumor-bearing mice.	norharman	11-25	protein tyrosine kinase 2	Homo sapiens	64-67
34602411-0	2021	Effects of beta-carboline alkaloids from Peganum harmala on the FAK/PI3K/AKT/Mtor pathway in human gastric cancer cell line SGC-7901 and tumor-bearing mice.	norharman	11-25	AKT serine/threonine kinase 1	Homo sapiens	73-76
34602411-0	2021	Effects of beta-carboline alkaloids from Peganum harmala on the FAK/PI3K/AKT/Mtor pathway in human gastric cancer cell line SGC-7901 and tumor-bearing mice.	norharman	11-25	mechanistic target of rapamycin kinase	Homo sapiens	77-81
34602411-12	2021	They may be targets of beta-carboline in FAK/PI3K/AKT/mTOR pathway.	norharman	23-37	protein tyrosine kinase 2	Homo sapiens	41-44
34602411-12	2021	They may be targets of beta-carboline in FAK/PI3K/AKT/mTOR pathway.	norharman	23-37	AKT serine/threonine kinase 1	Homo sapiens	50-53
34602411-12	2021	They may be targets of beta-carboline in FAK/PI3K/AKT/mTOR pathway.	norharman	23-37	mechanistic target of rapamycin kinase	Homo sapiens	54-58
35517822-6	2022	These NQO2 knockouts along with the parental cells were used to demonstrate that cellular NQO2 is unable to catalyze the activation of the DNA cross-linking reagent, CB1954, without the addition of exogenous dihydronicotinamide riboside (NRH).	norharman	238-241	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	90-94
35180487-1	2022	Cyclin-dependent kinase 4 (CDK4), which is involved in dynamic regulation of cell cycle, has gained particularly attention for its role in controlling tumor growth.Increasing evidence showed that beta-carboline derivatives have the potential to inhibit CDK4.	norharman	196-210	cyclin dependent kinase 4	Homo sapiens	27-31
35180487-1	2022	Cyclin-dependent kinase 4 (CDK4), which is involved in dynamic regulation of cell cycle, has gained particularly attention for its role in controlling tumor growth.Increasing evidence showed that beta-carboline derivatives have the potential to inhibit CDK4.	norharman	196-210	cyclin dependent kinase 4	Homo sapiens	253-257
35281060-6	2022	Our results show that only NRH supplementation strongly increased NAD+ levels in both bone marrow-derived and THP-1 macrophages.	norharman	27-30	GLI family zinc finger 2	Homo sapiens	110-115
35281060-9	2022	The effect of NRH in NAD+ boosting and gene expression was blocked by inhibitors of adenosine kinase, equilibrative nucleoside transporters (ENT), and IkappaB kinase (IKK).	norharman	14-17	adenosine kinase	Homo sapiens	84-100
3029781-1	1987	DBI (diazepam-binding inhibitor) is a putative neuromodulatory peptide isolated from rat brain that acts on gamma-aminobutyric acid-benzodiazepine-Cl- ionophore receptor complex inducing beta-carboline-like effects.	norharman	187-201	diazepam binding inhibitor	Rattus norvegicus	0-3
2821427-1	1987	Diazepam binding inhibitor (DBI) belongs to a family of newly discovered neuropeptides that, when acting on the benzodiazepine/beta-carboline recognition site, provide an allosteric modulation of the function of GABAA receptor.	norharman	127-141	diazepam binding inhibitor	Rattus norvegicus	0-32
34995924-0	2022	Discovery of novel beta-carboline derivatives as selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer"s disease.	norharman	19-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
34995924-0	2022	Discovery of novel beta-carboline derivatives as selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer"s disease.	norharman	19-33	glycogen synthase kinase 3 alpha	Homo sapiens	80-89
35056740-3	2022	Here, we designed and synthesized a novel theranostic agent H6M based on the "double-locked" strategy by introducing an electron-withdrawing nitro group into 1-position of a pH-responsive 3-amino-beta-carboline and further covalently linking the hydroxamic acid group, a zinc-binding group (ZBG), to the 3-position of beta-carboline to obtain histone deacetylase (HDAC) inhibitory effect for combined HDAC-targeted therapy.	norharman	318-332	phenylalanine hydroxylase	Homo sapiens	174-176
3029781-1	1987	DBI (diazepam-binding inhibitor) is a putative neuromodulatory peptide isolated from rat brain that acts on gamma-aminobutyric acid-benzodiazepine-Cl- ionophore receptor complex inducing beta-carboline-like effects.	norharman	187-201	diazepam binding inhibitor	Rattus norvegicus	5-31
6732863-0	1984	Effects of metyrapone and norharmane on microsomal mono-oxygenase and epoxide hydrolase activities.	norharman	26-36	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	40-65
3088605-6	1986	An increase in the concentration of norharman (NH) in PRP, ranging from 0.57 nmoles/l in control rats to 1.88 nmoles/l in serine treated porphyric rats was found.	norharman	36-45	proline rich protein 2-like 1	Rattus norvegicus	54-57
3020548-1	1986	Diazepam binding inhibitor (DBI) is a protein that displaces ligands bound to the beta-carboline/benzodiazepine recognition site, an allosteric modulatory site of the type A gamma-aminobutyric acid receptor complex.	norharman	82-96	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-26
3020548-1	1986	Diazepam binding inhibitor (DBI) is a protein that displaces ligands bound to the beta-carboline/benzodiazepine recognition site, an allosteric modulatory site of the type A gamma-aminobutyric acid receptor complex.	norharman	82-96	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	28-31
6431906-0	1984	Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives.	norharman	76-90	tryptophan 2,3-dioxygenase	Homo sapiens	46-72
6431906-1	1984	beta-Carboline derivatives inhibited both indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase activities from various sources.	norharman	0-14	tryptophan 2,3-dioxygenase	Homo sapiens	74-100
6431906-3	1984	Kinetic studies revealed that norharman is uncompetitive (Ki = 0.12 mM) with L-tryptophan for rabbit intestinal indoleamine 2,3-dioxygenase, and linearly competitive (Ki = 0.29 mM) with L-tryptophan for mouse liver tryptophan 2,3-dioxygenase.	norharman	30-39	tryptophan 2,3-dioxygenase	Mus musculus	215-241
6732863-1	1984	This study was undertaken to examine the possibility that metyrapone and norharmane stimulate epoxide hydrolase and inhibit mono-oxygenase activities by binding to a cytochrome P-450 component of a stable complex containing the two enzymes.	norharman	73-83	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	166-182
6732863-9	1984	These findings suggest that metyrapone and norharmane act at separate sites on both cytochrome P-450 and epoxide hydrolase.	norharman	43-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
33626096-4	2021	Harmine is a beta-carboline alkaloid found in a variety of plants and was recently shown to be able to induce degradation of Twist Family BHLH Transcription Factor 1 (Twist1) in non-small cell lung cancer cells (NSCLC).	norharman	13-27	twist family bHLH transcription factor 1	Homo sapiens	167-173
33784074-6	2021	NRH, like NADH and NADPH, is prone to degradation via oxidation, hydration, and isomerization and, as such, is an excellent model compound to rationalize the nonenzymatic metabolism of NAD(P)H in a biological context.	norharman	0-3	2,4-dienoyl-CoA reductase 1	Homo sapiens	19-24
358980-0	1978	Differences in effects of norharman with various classes of chemical mutagens and amounts of S-9.	norharman	26-35	ribosomal protein S9	Homo sapiens	93-96
32592323-0	2020	Novel beta-carboline-based indole-4,7-quinone derivatives as NQO1 inhibitor with potent antitumor activities by inducing ROS, apoptosis, and DNA damage.	norharman	6-20	NAD(P)H quinone dehydrogenase 1	Homo sapiens	61-65
33536926-0	2020	Novel Hybrid CHC from beta-carboline and N-Hydroxyacrylamide Overcomes Drug-Resistant Hepatocellular Carcinoma by Promoting Apoptosis, DNA Damage, and Cell Cycle Arrest.	norharman	22-36	clathrin heavy chain	Homo sapiens	13-16
33536926-1	2020	A novel hybrid CHC was designed and synthesized by conjugating beta-carboline with an important active fragment N-hydroxyacrylamide of histone deacetylase (HDAC) inhibitor by an amide linkage to enhance antitumor efficacy/potency or even block drug resistance.	norharman	63-77	clathrin heavy chain	Homo sapiens	15-18
33599108-0	2021	Synthesis and Assessment of fused beta-carboline derivatives as Kappa Opioid Receptor agonist.	norharman	34-48	opioid receptor kappa 1	Homo sapiens	64-85
33339338-1	2020	The beta-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application.	norharman	4-18	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	48-54
33339338-1	2020	The beta-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application.	norharman	4-18	monoamine oxidase A	Homo sapiens	114-119
33166357-8	2020	PUMA and BAX mediate the cell-specific cytotoxicity of NRH in HepG3.	norharman	55-58	BCL2 binding component 3	Homo sapiens	0-4
33166357-8	2020	PUMA and BAX mediate the cell-specific cytotoxicity of NRH in HepG3.	norharman	55-58	BCL2 associated X, apoptosis regulator	Homo sapiens	9-12
32787089-1	2020	Two novel theranostic agents HJTA and HJTB have been designed and synthesized by covalently linking a beta-carboline derivative, with antitumor activities and pH-responsive fluorescence, with a 2-exomethylenecyclohexanone moiety, which can be activated by the tumor-targeting glutathione (GSH)/glutathione S-transferase pi (GSTpi).	norharman	102-116	jumping translocation breakpoint	Homo sapiens	38-42
32761352-3	2020	The beta-carboline harmine, which induces hypothermia and tremor, is metabolized by CYP2D6 to the non-hypothermic/non-tremorgenic harmol.	norharman	4-18	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	84-90
32761352-11	2020	These findings suggest that human CYP2D6 in the brain is protective against beta-carboline-induced neurotoxicity and that the extensive interindividual variability in CYP2D6 expression in human brain may contribute to variation in susceptibility to certain neurotoxin-associated neurodegenerative disorders.	norharman	76-90	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	34-40
32835667-6	2020	As a class of hopeful beta-carboline derivatives, growing evidence has indicated their auspicious roles in combating cancer by inhibiting topoisomerase (TOPO), kinesin Eg5, telomerase, cyclin-dependent kinase (CDK), IkappaB kinase (IKK), and polo-like kinase-1 (PLK1) in the transition phases of cell cycle.	norharman	22-36	kinesin family member 11	Homo sapiens	168-171
32835667-6	2020	As a class of hopeful beta-carboline derivatives, growing evidence has indicated their auspicious roles in combating cancer by inhibiting topoisomerase (TOPO), kinesin Eg5, telomerase, cyclin-dependent kinase (CDK), IkappaB kinase (IKK), and polo-like kinase-1 (PLK1) in the transition phases of cell cycle.	norharman	22-36	polo like kinase 1	Homo sapiens	242-260
32835667-6	2020	As a class of hopeful beta-carboline derivatives, growing evidence has indicated their auspicious roles in combating cancer by inhibiting topoisomerase (TOPO), kinesin Eg5, telomerase, cyclin-dependent kinase (CDK), IkappaB kinase (IKK), and polo-like kinase-1 (PLK1) in the transition phases of cell cycle.	norharman	22-36	polo like kinase 1	Homo sapiens	262-266
32870229-1	2020	Employing TBN/TEMPO as the catalysts and oxygen as the oxidant, the biologically and pharmaceutically significant tetrahydro-beta-carboline and beta-carboline alkaloid scaffolds that used to be obtained by multi-step processes can now be selectively obtained in only one-step via direct aerobic oxidative Pictet-Spengler reactions of tryptamines with alcohols under mild conditions, with water generated as the byproduct.	norharman	125-139	TATA-box binding protein associated factor 8	Homo sapiens	10-13
32787109-0	2020	Exploration of TRPM8 Binding Sites by beta-Carboline-based Antagonists and Their In Vitro Characterization and in Vivo Analgesic Activities.	norharman	38-52	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	15-20
32278957-5	2020	All the alterations suggest that norharmane alters polar auxin transport by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of A. thaliana seedlings.	norharman	33-43	Auxin efflux carrier family protein	Arabidopsis thaliana	87-91
32905276-3	2020	In this study, we have chosen harmaline, one of the beta-carboline alkaloids, and report its mechanism of binding to SphK1 and subsequent inhibition.	norharman	52-66	sphingosine kinase 1	Homo sapiens	117-122
32278957-5	2020	All the alterations suggest that norharmane alters polar auxin transport by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of A. thaliana seedlings.	norharman	33-43	Auxin efflux carrier family protein	Arabidopsis thaliana	93-97
32278957-5	2020	All the alterations suggest that norharmane alters polar auxin transport by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of A. thaliana seedlings.	norharman	33-43	Auxin efflux carrier family protein	Arabidopsis thaliana	102-106
32694608-0	2020	NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase.	norharman	0-3	adenosine kinase	Mus musculus	67-83
31154274-1	2019	BACKGROUND: beta-Carboline alkaloid harmine (HAR) and harmaline (HAL) are monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitors.	norharman	12-26	acetylcholinesterase	Rattus norvegicus	102-122
31400494-9	2019	Pre-test administration of morphine (1 mug/mouse, intra-CA1) also inhibited amnesia induced by pre-training intra-CA1 microinjection of norharmane (10 mug/mouse) and vice versa, suggesting a cross SDM between the drugs.	norharman	136-146	carbonic anhydrase 1	Mus musculus	56-59
31400494-9	2019	Pre-test administration of morphine (1 mug/mouse, intra-CA1) also inhibited amnesia induced by pre-training intra-CA1 microinjection of norharmane (10 mug/mouse) and vice versa, suggesting a cross SDM between the drugs.	norharman	136-146	carbonic anhydrase 1	Mus musculus	114-117
31401535-3	2019	To develop metal-based Mcl-1inhibitors, twenty two copper(II) complexes 25-46 with 9-substituted beta-carboline derivatives were reported.	norharman	97-111	myeloid cell leukemia sequence 1	Mus musculus	23-28
31141766-0	2019	beta-carboline-based turn-on fluorescence chemosensor for quantitative detection of fluoride at PPB level.	norharman	0-14	histatin 1	Homo sapiens	96-99
31154274-1	2019	BACKGROUND: beta-Carboline alkaloid harmine (HAR) and harmaline (HAL) are monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitors.	norharman	12-26	acetylcholinesterase	Rattus norvegicus	124-128
30712126-0	2019	Correction to: Identification of beta-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages.	norharman	33-47	nitric oxide synthase 2	Homo sapiens	160-164
29451015-5	2019	Anti-inflammatory activity studies on 13 isolated compounds showed that beta-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-alpha, IL-6 and IL-1beta in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells.	norharman	72-86	tumor necrosis factor	Mus musculus	177-186
29451015-5	2019	Anti-inflammatory activity studies on 13 isolated compounds showed that beta-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-alpha, IL-6 and IL-1beta in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells.	norharman	72-86	interleukin 6	Mus musculus	188-192
29451015-5	2019	Anti-inflammatory activity studies on 13 isolated compounds showed that beta-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-alpha, IL-6 and IL-1beta in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells.	norharman	72-86	interleukin 1 beta	Mus musculus	197-205
31015177-1	2019	A new series of beta-Carboline/Schiff bases was designed, synthesized, characterised and biologically evaluated as inhibitors of PLK-1.	norharman	16-30	polo like kinase 1	Mus musculus	129-134
31120744-0	2019	Hydroxamic Acid Derivatives of beta-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways.	norharman	31-45	AKT serine/threonine kinase 1	Homo sapiens	125-128
31120744-0	2019	Hydroxamic Acid Derivatives of beta-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways.	norharman	31-45	mechanistic target of rapamycin kinase	Homo sapiens	129-133
30948509-8	2019	Studies to identify its biochemical mechanism of action showed that it does not inhibit NAD+ consumption, suggesting that it acts as a biochemical precursor to NAD+ Cell lysates possess an ATP-dependent kinase activity that efficiently converts NRH to the compound NMNH, but independent of Nrk1 or Nrk2.	norharman	245-248	nicotinamide riboside kinase 1	Homo sapiens	290-294
30948509-8	2019	Studies to identify its biochemical mechanism of action showed that it does not inhibit NAD+ consumption, suggesting that it acts as a biochemical precursor to NAD+ Cell lysates possess an ATP-dependent kinase activity that efficiently converts NRH to the compound NMNH, but independent of Nrk1 or Nrk2.	norharman	245-248	nicotinamide riboside kinase 2	Homo sapiens	298-302
30712126-0	2019	Correction to: Identification of beta-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages.	norharman	33-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
29678521-4	2018	17beta-Estradiol, menadione, norharmane and raloxifene exhibited marked differences in inhibitory effects between the human and mouse AOX isoforms when the phthalazine substrate was used.	norharman	29-39	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	134-137
30826506-5	2019	The results demonstrated that some of these beta-carboline derivatives exhibited moderate to good cytotoxic activities, especially, compound 9o with a special sulfonyl group presented the highest inhibitory activities against all tested cell lines with the IC50 values of 6.82 +- 0.98, 8.43 +- 1.93, 7.69 +- 2.17, 7.19 +- 1.43 muM, respectively, which might be used as lead compound for discovery of novel cytotoxic agents.	norharman	44-58	latexin	Homo sapiens	327-330
30324332-0	2019	Identification of beta-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages.	norharman	18-32	nitric oxide synthase 2, inducible	Mus musculus	145-149
30324332-0	2019	Identification of beta-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages.	norharman	18-32	prostaglandin-endoperoxide synthase 2	Mus musculus	154-159
30864598-3	2019	Herein, two phosphorescent Re(i) tricarbonyl complexes (Re1 and Re2) bearing beta-carboline derivatives have been synthesized and characterized.	norharman	77-91	G protein-coupled receptor 161	Homo sapiens	64-67
30079021-0	2018	A Small beta-Carboline Derivative "B-9-3" Modulates TGF-beta Signaling Pathway Causing Tumor Regression in Vivo.	norharman	8-22	transforming growth factor beta 1	Homo sapiens	52-60
28397836-7	2018	A reversal of the behavioural phenotype with beta-carboline, an anxiogenic inverse benzodiazepine receptor agonist, normalized alcohol preference in EFhd2 KO mice, demonstrating an EFhd2-driven relationship between personality traits and alcohol preference.	norharman	45-59	EF hand domain containing 2	Mus musculus	149-154
28397836-7	2018	A reversal of the behavioural phenotype with beta-carboline, an anxiogenic inverse benzodiazepine receptor agonist, normalized alcohol preference in EFhd2 KO mice, demonstrating an EFhd2-driven relationship between personality traits and alcohol preference.	norharman	45-59	EF hand domain containing 2	Mus musculus	181-186
29143974-10	2018	Expression of KRT14, a bladder stem cell marker, was also increased in the basal layer by the two norharman derivatives.	norharman	98-107	keratin 14	Rattus norvegicus	14-19
29288941-2	2018	Several of these beta-carboline derivatives not only showed excellent HDAC1/3/6 inhibitory effects, but also displayed significant antitumor activities against five human cancer cells.	norharman	17-31	histone deacetylase 1	Homo sapiens	70-75
29367595-7	2018	Molecular docking studies showed that the compounds could combine with the active site of AChE by the pi-pi or cation-pi action between the carboline ring and the phenyl rings of the residues, and the beta-carboline moiety is embedded in a cavity surrounded by four aromatic residues of Trp86, Tyr337, Trp439 and Tyr449.	norharman	201-215	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
29387014-0	2018	Inhibiting beta-Catenin by beta-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy.	norharman	27-41	catenin beta 1	Homo sapiens	11-23
29387014-0	2018	Inhibiting beta-Catenin by beta-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy.	norharman	27-41	MDM2 proto-oncogene	Homo sapiens	47-51
29387014-4	2018	We have recently identified a novel class of beta-carboline compounds as the specific and potent MDM2 inhibitors, including a lead compound SP141.	norharman	45-59	MDM2 proto-oncogene	Homo sapiens	97-101
29387014-5	2018	In the present study, we utilized SP141 as an exemplary beta-carboline compound to characterize beta-catenin as a molecular target of the beta-carboline compounds and to demonstrate an important role of beta-catenin in the anticancer activity of beta-carboline.	norharman	138-152	catenin beta 1	Homo sapiens	96-108
29387014-5	2018	In the present study, we utilized SP141 as an exemplary beta-carboline compound to characterize beta-catenin as a molecular target of the beta-carboline compounds and to demonstrate an important role of beta-catenin in the anticancer activity of beta-carboline.	norharman	138-152	catenin beta 1	Homo sapiens	96-108
29387014-10	2018	We envision that beta-carboline derivatives can be developed as promising dual inhibitors of beta-catenin and MDM2 for the treatment of advanced pancreatic cancer.	norharman	17-31	catenin beta 1	Homo sapiens	93-105
29387014-10	2018	We envision that beta-carboline derivatives can be developed as promising dual inhibitors of beta-catenin and MDM2 for the treatment of advanced pancreatic cancer.	norharman	17-31	MDM2 proto-oncogene	Homo sapiens	110-114
27977936-11	2017	hOCT1 and hOCT3 are less sensitive to beta-carboline inhibition.	norharman	38-52	solute carrier family 22 member 1	Homo sapiens	0-5
27977936-11	2017	hOCT1 and hOCT3 are less sensitive to beta-carboline inhibition.	norharman	38-52	solute carrier family 22 member 3	Homo sapiens	10-15
28923379-3	2017	Notably, Ru1 and Ru2 exhibit potent antiproliferative activities against selected human cancer cell lines with IC50 values lower than those of cisplatin and other non-cyclometalated Ru(II) beta-carboline complexes.	norharman	189-203	Scm like with four mbt domains 1	Homo sapiens	9-12